ranitidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 2358 66357-35-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zantac
  • zenetac
  • ranitidine hydrochloride
  • ranitidine HCl
  • ranitidine
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
  • Molecular weight: 314.40
  • Formula: C13H22N4O3S
  • CLOGP: 0.67
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 83.58
  • ALOGS: -3.60
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 28.50 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
S (Water solubility) 660 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 69 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.95 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 58
kinase-selectivity-class AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAPK7,TEK 7
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.811 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 29, 1977 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Breast cancer female 25186.35 9.52 6418 282833 8468 90330728
Breast cancer stage I 24774.90 9.52 5817 283434 3807 90335389
Breast cancer stage II 13680.54 9.52 4886 284365 30448 90308748
Colorectal cancer 11601.52 9.52 2653 286598 1240 90337956
Renal cancer 8127.26 9.52 2167 287084 3778 90335418
Bladder cancer 7875.62 9.52 2103 287148 3698 90335498
Breast cancer stage IV 7224.83 9.52 1601 287650 437 90338759
Oesophageal carcinoma 7060.77 9.52 1642 287609 946 90338250
Colorectal cancer stage III 6715.78 9.52 1413 287838 0 90339196
Colorectal cancer stage IV 6356.74 9.52 1340 287911 12 90339184
Hepatic cancer stage IV 4904.84 9.52 1034 288217 9 90339187
Breast cancer stage III 4888.10 9.52 3154 286097 81293 90257903
Gastric cancer 4655.33 9.52 1357 287894 3779 90335417
Pancreatic carcinoma stage IV 4564.89 9.52 974 288277 66 90339130
Colorectal cancer stage II 3925.02 9.52 826 288425 0 90339196
Hepatic cancer 3733.05 9.52 1131 288120 3750 90335446
Uterine cancer 3560.75 9.52 1116 288135 4269 90334927
Colorectal cancer stage I 2974.44 9.52 626 288625 0 90339196
Pancreatic carcinoma 2939.55 9.52 1079 288172 7298 90331898
Renal cancer stage I 2890.66 9.52 609 288642 3 90339193
Lung carcinoma cell type unspecified stage IV 2703.16 9.52 667 288584 679 90338517
Gastric cancer stage IV 2660.92 9.52 575 288676 76 90339120
Renal cancer stage IV 2435.06 9.52 520 288731 37 90339159
Gastrointestinal carcinoma 2087.81 9.52 606 288645 1651 90337545
Renal cancer stage II 1976.04 9.52 419 288832 15 90339181
Thyroid cancer 1965.41 9.52 744 288507 5540 90333656
Renal cancer stage III 1734.13 9.52 365 288886 0 90339196
Gastric cancer stage I 1729.38 9.52 364 288887 0 90339196
Lung neoplasm malignant 1616.35 9.52 992 288259 23281 90315915
Bladder cancer stage IV 1534.57 9.52 323 288928 0 90339196
Bladder cancer stage II 1282.74 9.52 270 288981 0 90339196
Lung carcinoma cell type unspecified stage I 1155.37 9.52 255 288996 63 90339133
Gastric cancer stage II 1149.70 9.52 242 289009 0 90339196
Pancreatic carcinoma stage III 1130.70 9.52 238 289013 0 90339196
Brain neoplasm malignant 1002.31 9.52 300 288951 941 90338255
Gastric cancer stage III 994.70 9.52 210 289041 3 90339193
Pancreatic carcinoma stage II 983.41 9.52 207 289044 0 90339196
Haematological malignancy 932.02 9.52 230 289021 234 90338962
Thyroid cancer stage I 907.39 9.52 191 289060 0 90339196
Bladder cancer stage III 888.39 9.52 187 289064 0 90339196
Lung carcinoma cell type unspecified stage III 828.08 9.52 192 289059 106 90339090
Ovarian cancer 792.32 9.52 401 288850 6366 90332830
Pancreatic carcinoma stage I 766.65 9.52 162 289089 3 90339193
Skin cancer 734.38 9.52 486 288765 13033 90326163
Lung carcinoma cell type unspecified stage II 629.44 9.52 143 289108 60 90339136
Ovarian cancer stage IV 584.25 9.52 144 289107 145 90339051
Neoplasm malignant 576.59 9.52 623 288628 33257 90305939
Hepatic cancer stage III 560.57 9.52 118 289133 0 90339196
Drug ineffective 556.36 9.52 2407 286844 1381891 88957305
Ovarian cancer stage I 555.82 9.52 117 289134 0 90339196
Hepatic cancer stage II 555.82 9.52 117 289134 0 90339196
Hepatic cancer stage I 546.32 9.52 115 289136 0 90339196
Disease progression 541.07 9.52 1398 287853 155217 90183979
Food allergy 457.36 9.52 482 288769 24996 90314200
Thyroid cancer stage II 456.06 9.52 96 289155 0 90339196
Breast cancer 421.53 9.52 675 288576 53086 90286110
Cervix carcinoma 419.17 9.52 208 289043 3158 90336038
Appendix cancer 414.91 9.52 97 289154 59 90339137
Bone cancer 363.35 9.52 152 289099 1510 90337686
Temperature regulation disorder 353.37 9.52 325 288926 14254 90324942
Throat cancer 345.96 9.52 121 289130 696 90338500
Toxicity to various agents 342.79 9.52 251 289000 287595 90051601
Ovarian cancer stage III 339.64 9.52 97 289154 244 90338952
Small intestine carcinoma 336.50 9.52 106 289145 413 90338783
Ovarian cancer stage II 311.65 9.52 67 289184 7 90339189
Thyroid cancer stage IV 299.28 9.52 63 289188 0 90339196
Schizoaffective disorder 298.99 9.52 193 289058 4954 90334242
Rheumatoid factor positive 295.65 9.52 90 289161 171560 90167636
Thyroid cancer stage III 280.28 9.52 59 289192 0 90339196
Small intestine carcinoma stage IV 270.78 9.52 57 289194 0 90339196
Sleep disorder due to general medical condition, insomnia type 264.26 9.52 46 289205 128648 90210548
Immunodeficiency 259.07 9.52 482 288769 42752 90296444
Thyroid cancer stage 0 256.53 9.52 54 289197 0 90339196
Cervix carcinoma stage I 252.12 9.52 55 289196 10 90339186
Completed suicide 249.90 9.52 76 289175 144982 90194214
Blepharospasm 247.50 9.52 547 288704 54898 90284298
Alopecia 241.45 9.52 793 288458 494278 89844918
Gastrooesophageal reflux disease 239.43 9.52 1109 288142 165228 90173968
Coeliac disease 231.47 9.52 468 288783 44142 90295054
Death 204.60 9.52 758 288493 455793 89883403
Taste disorder 202.71 9.52 540 288711 61006 90278190
Discomfort 201.47 9.52 354 288897 273981 90065215
Sinusitis 201.32 9.52 503 288748 342585 89996611
Gastric cancer stage 0 194.77 9.52 41 289210 0 90339196
Cervix carcinoma stage II 193.34 9.52 45 289206 26 90339170
Prostate cancer 190.02 9.52 40 289211 0 90339196
Urinary sediment present 189.95 9.52 106 289145 2068 90337128
Arthropathy 184.45 9.52 578 288673 365664 89973532
Cervix carcinoma stage IV 183.73 9.52 45 289206 43 90339153
Erythema 179.46 9.52 1300 287951 227946 90111250
Rash erythematous 177.06 9.52 533 288718 64571 90274625
Crystal urine present 176.48 9.52 89 289162 1401 90337795
Systemic lupus erythematosus 176.07 9.52 580 288671 361316 89977880
Gallbladder cancer 172.88 9.52 60 289191 336 90338860
Gallbladder cancer stage IV 171.02 9.52 36 289215 0 90339196
Condition aggravated 170.36 9.52 1157 288094 594388 89744808
Colon cancer stage IV 170.11 9.52 54 289197 217 90338979
Urine abnormality 165.58 9.52 161 289090 7576 90331620
Bursitis 165.15 9.52 844 288407 130810 90208386
Infection 159.63 9.52 605 288646 361489 89977707
Drug abuse 157.35 9.52 35 289216 82312 90256884
Colon cancer stage III 154.89 9.52 45 289206 123 90339073
Swollen joint count increased 154.38 9.52 81 289170 111125 90228071
Glossodynia 148.82 9.52 527 288724 321252 90017944
Off label use 148.71 9.52 2551 286700 1099701 89239495
Injection site pain 147.65 9.52 203 289048 173496 90165700
Pemphigus 147.41 9.52 541 288710 326323 90012873
Colorectal carcinoma stage 0 147.27 9.52 31 289220 0 90339196
Hand deformity 145.47 9.52 473 288778 295889 90043307
Oedema 143.81 9.52 262 288989 200033 90139163
Lymphocyte count decreased 141.11 9.52 332 288919 34718 90304478
Urine leukocyte esterase positive 138.37 9.52 101 289150 3181 90336015
Intentional overdose 138.37 9.52 63 289188 93771 90245425
Cervix carcinoma stage III 138.36 9.52 35 289216 43 90339153
Colon cancer 137.16 9.52 172 289079 10772 90328424
Bladder cancer stage I, with cancer in situ 133.01 9.52 28 289223 0 90339196
Onychomadesis 132.13 9.52 384 288867 45614 90293582
Lymphoma 131.12 9.52 188 289063 13403 90325793
Red blood cells urine positive 126.44 9.52 95 289156 3130 90336066
Synovitis 125.46 9.52 583 288668 329169 90010027
Nail disorder 124.97 9.52 444 288807 58623 90280573
Epilepsy 122.58 9.52 554 288697 81652 90257544
Urine analysis abnormal 121.90 9.52 114 289137 5107 90334089
Loss of personal independence in daily activities 119.80 9.52 155 289096 135950 90203246
Knee arthroplasty 119.34 9.52 58 289193 83124 90256072
Swelling 116.77 9.52 820 288431 418238 89920958
Neutrophil percentage increased 116.71 9.52 88 289163 2915 90336281
Hip arthroplasty 115.79 9.52 49 289202 76159 90263037
Lymphocyte percentage decreased 115.73 9.52 89 289162 3038 90336158
Colon cancer stage I 114.78 9.52 30 289221 46 90339150
Anaemia 113.82 9.52 660 288591 352142 89987054
Fall 110.54 9.52 994 288257 480816 89858380
Toothache 109.15 9.52 228 289023 22002 90317194
White blood cells urine positive 107.92 9.52 118 289133 6380 90332816
Arthritis 107.09 9.52 234 289017 167081 90172115
Lung carcinoma cell type unspecified stage 0 106.45 9.52 23 289228 3 90339193
Foetal death 104.64 9.52 215 289036 20508 90318688
Therapy non-responder 104.32 9.52 172 289079 136532 90202664
Myelosuppression 103.96 9.52 22 289229 53569 90285627
Hyperhidrosis 103.73 9.52 768 288483 135537 90203659
COVID-19 100.91 9.52 245 289006 168598 90170598
Malignant neoplasm progression 100.06 9.52 116 289135 106754 90232442
Flushing 99.12 9.52 550 288701 87941 90251255
Product dose omission issue 96.57 9.52 541 288710 291146 90048050
Abdominal discomfort 96.31 9.52 1016 288235 476312 89862884
Small intestine carcinoma stage II 95.01 9.52 20 289231 0 90339196
Therapeutic response decreased 92.27 9.52 90 289161 89639 90249557
Pancytopenia 92.06 9.52 151 289100 120112 90219084
Wound 91.29 9.52 579 288672 302401 90036795
Acute kidney injury 89.64 9.52 626 288625 319761 90019435
Therapy interrupted 88.56 9.52 25 289226 50083 90289113
Arthralgia 87.66 9.52 1857 287394 776665 89562531
Anti-cyclic citrullinated peptide antibody positive 87.53 9.52 422 288829 236011 90103185
Product quality issue 87.49 9.52 491 288760 78834 90260362
Anaphylactic reaction 86.97 9.52 527 288724 86997 90252199
Colon cancer stage II 86.17 9.52 31 289220 196 90339000
Anhedonia 86.12 9.52 141 289110 11290 90327906
Pancreatic carcinoma stage 0 85.51 9.52 18 289233 0 90339196
Macular degeneration 83.81 9.52 11 289240 37959 90301237
Suicide attempt 83.03 9.52 71 289180 75328 90263868
Lactic acidosis 80.67 9.52 30 289221 50433 90288763
Upper respiratory tract infection 79.62 9.52 690 288561 127628 90211568
Accidental exposure to product 78.95 9.52 19 289232 42347 90296849
Pleuritic pain 78.76 9.52 129 289122 10332 90328864
Pneumonia 78.64 9.52 1499 287752 636560 89702636
Computerised tomogram thorax abnormal 78.55 9.52 60 289191 2027 90337169
Maternal exposure during pregnancy 76.45 9.52 757 288494 359306 89979890
Fatigue 76.42 9.52 2963 286288 1151060 89188136
Small intestine carcinoma stage III 76.01 9.52 16 289235 0 90339196
Small intestine carcinoma stage I 76.01 9.52 16 289235 0 90339196
Septic shock 75.96 9.52 94 289157 84066 90255130
Tenosynovitis stenosans 74.90 9.52 77 289174 3876 90335320
Drug resistance 74.49 9.52 6 289245 30443 90308753
Lower limb fracture 73.58 9.52 98 289153 84915 90254281
Haemoglobin urine present 73.47 9.52 40 289211 742 90338454
Hepatic cytolysis 73.17 9.52 7 289244 30909 90308287
Device expulsion 73.00 9.52 20 289231 40866 90298330
Renal impairment 72.90 9.52 141 289110 105280 90233916
Bacterial test 72.08 9.52 45 289206 1088 90338108
Delirium 71.80 9.52 140 289111 104219 90234977
Gallbladder cancer stage II 71.26 9.52 15 289236 0 90339196
Joint swelling 70.38 9.52 1156 288095 502144 89837052
Chronic kidney disease 69.47 9.52 331 288920 49860 90289336
Brain cancer metastatic 69.10 9.52 25 289226 161 90339035
Onychomycosis 69.07 9.52 269 288982 37107 90302089
Blood urine present 68.82 9.52 163 289088 17115 90322081
Drug level increased 67.80 9.52 219 289032 27543 90311653
Multiple organ dysfunction syndrome 67.46 9.52 71 289180 68265 90270931
Back injury 67.11 9.52 311 288940 46311 90292885
Computerised tomogram thorax 67.03 9.52 33 289218 492 90338704
Road traffic accident 66.83 9.52 153 289098 107473 90231723
Synovial fluid analysis 66.70 9.52 62 289189 2756 90336440
Nasal cavity cancer 65.59 9.52 20 289231 68 90339128
Loss of employment 65.50 9.52 63 289188 2924 90336272
Intraductal proliferative breast lesion 64.96 9.52 67 289184 3386 90335810
Depressed level of consciousness 64.95 9.52 82 289169 72702 90266494
Bacterial test positive 64.60 9.52 84 289167 5455 90333741
Pericarditis 63.32 9.52 554 288697 269597 90069599
Drug eruption 61.95 9.52 18 289233 35389 90303807
Cerebrovascular accident 61.35 9.52 196 289055 123337 90215859
Red blood cell sedimentation rate increased 61.08 9.52 106 289145 82489 90256707
Finger deformity 59.36 9.52 235 289016 32662 90306534
Helicobacter infection 59.19 9.52 452 288799 226398 90112798
Contusion 58.51 9.52 516 288735 250700 90088496
Peripheral venous disease 58.32 9.52 463 288788 83458 90255738
Sciatica 58.31 9.52 150 289101 101232 90237964
Atelectasis 58.21 9.52 191 289060 24218 90314978
Abortion spontaneous 58.19 9.52 52 289199 54004 90285192
Injection site erythema 58.00 9.52 144 289107 98358 90240838
Anti-cyclic citrullinated peptide antibody 57.48 9.52 9 289242 27212 90311984
Duodenal ulcer perforation 57.23 9.52 442 288809 220846 90118350
Fluid retention 56.37 9.52 477 288774 87614 90251582
Pharyngitis 56.22 9.52 176 289075 21771 90317425
Gamma-glutamyltransferase decreased 56.18 9.52 26 289225 335 90338861
Hyperkalaemia 56.11 9.52 75 289176 64889 90274307
Musculoskeletal stiffness 55.42 9.52 642 288609 295890 90043306
Weight increased 54.79 9.52 971 288280 416956 89922240
Urinary tract infection 54.71 9.52 668 288583 304964 90034232
Neutropenia 54.58 9.52 457 288794 224447 90114749
General physical health deterioration 54.20 9.52 802 288449 354313 89984883
Drug reaction with eosinophilia and systemic symptoms 53.86 9.52 35 289216 42723 90296473
Red blood cell sedimentation rate abnormal 53.45 9.52 7 289244 24197 90314999
Mastocytosis 53.45 9.52 35 289216 921 90338275
Product use in unapproved indication 53.19 9.52 754 288497 335482 90003714
Deep vein thrombosis postoperative 53.16 9.52 90 289161 70719 90268477
Infusion site coldness 53.08 9.52 22 289229 213 90338983
Pulmonary fibrosis 53.08 9.52 171 289080 107332 90231864
Joint dislocation 52.83 9.52 39 289212 44543 90294653
Monocyte percentage increased 52.81 9.52 38 289213 1170 90338026
Pyrexia 52.71 9.52 1656 287595 658829 89680367
Colitis ulcerative 52.63 9.52 69 289182 60197 90278999
Decreased appetite 52.54 9.52 865 288386 375675 89963521
Anal cancer stage III 52.26 9.52 11 289240 0 90339196
Oesophageal carcinoma stage 0 52.26 9.52 11 289240 0 90339196
Tongue carcinoma stage IV 52.26 9.52 11 289240 0 90339196
Anal cancer stage II 52.26 9.52 11 289240 0 90339196
Perfume sensitivity 52.17 9.52 35 289216 960 90338236
Myocardial infarction 52.02 9.52 169 289082 105803 90233393
Pain 51.47 9.52 2628 286623 993713 89345483
Rectal haemorrhage 51.06 9.52 118 289133 82626 90256570
Leukaemia 51.03 9.52 71 289180 4921 90334275
Urticaria 50.68 9.52 1332 287919 311402 90027794
Sinus rhythm 50.31 9.52 39 289212 1347 90337849
Bronchopulmonary aspergillosis allergic 50.11 9.52 61 289190 3705 90335491
Drug intolerance 49.54 9.52 1070 288181 446521 89892675
Abdominal pain upper 49.40 9.52 1401 287850 331273 90007923
Serotonin syndrome 49.12 9.52 30 289221 37857 90301339
Drug tolerance decreased 48.26 9.52 21 289230 32109 90307087
Mean cell haemoglobin decreased 48.07 9.52 74 289177 5621 90333575
Hepatic cancer metastatic 47.81 9.52 25 289226 426 90338770
Autoimmune disorder 47.72 9.52 109 289142 76635 90262561
Mobility decreased 47.56 9.52 541 288710 250193 90089003
Gallbladder cancer stage I 47.50 9.52 10 289241 0 90339196
Prostate cancer stage IV 47.50 9.52 10 289241 0 90339196
Scleritis 47.27 9.52 70 289181 5138 90334058
Cervix carcinoma stage 0 47.26 9.52 27 289224 552 90338644
Urine ketone body present 47.07 9.52 49 289202 2503 90336693
Drug ineffective for unapproved indication 47.06 9.52 88 289163 66556 90272640
Brain stem glioma 46.96 9.52 19 289232 172 90339024
Hypotension 46.88 9.52 743 288508 324654 90014542
Osteoporosis 46.65 9.52 155 289096 96376 90242820
Chronic obstructive pulmonary disease 46.60 9.52 104 289147 73725 90265471
Sepsis 46.56 9.52 359 288892 179455 90159741
Nasopharyngitis 46.27 9.52 969 288282 406135 89933061
Therapeutic product effect decreased 45.84 9.52 617 288634 276954 90062242
Pregnancy 45.54 9.52 80 289171 61967 90277229
Treatment failure 45.47 9.52 689 288562 303239 90035957
Ear infection 45.11 9.52 97 289154 69678 90269518
Deep vein thrombosis 45.05 9.52 146 289105 91474 90247722
Nitrite urine present 45.02 9.52 33 289218 1046 90338150
Total lung capacity decreased 44.96 9.52 58 289193 3737 90335459
Stomatitis 44.50 9.52 613 288638 274085 90065111
Allergy to chemicals 43.89 9.52 57 289194 3697 90335499
Adjustment disorder with depressed mood 43.66 9.52 71 289180 56682 90282514
Atrial fibrillation 43.53 9.52 249 289002 133362 90205834
Adverse drug reaction 43.33 9.52 208 289043 116493 90222703
Illness 42.86 9.52 127 289124 81842 90257354
Respiratory failure 42.85 9.52 213 289038 118205 90220991
Laryngeal cancer stage I 42.75 9.52 9 289242 0 90339196
Gallbladder cancer stage III 42.75 9.52 9 289242 0 90339196
Prostate cancer stage I 42.75 9.52 9 289242 0 90339196
Adrenal gland cancer 42.68 9.52 13 289238 44 90339152
Wrong technique in product usage process 42.62 9.52 104 289147 71467 90267729
Gait disturbance 42.30 9.52 581 288670 259915 90079281
Tongue neoplasm malignant stage unspecified 42.05 9.52 30 289221 911 90338285
Disease recurrence 42.01 9.52 35 289216 37618 90301578
Paraesthesia 41.94 9.52 1071 288180 249255 90089941
C-reactive protein 41.84 9.52 24 289227 31343 90307853
Muscle spasticity 41.72 9.52 31 289220 35291 90303905
Posterior reversible encephalopathy syndrome 41.66 9.52 10 289241 22329 90316867
Rhabdomyolysis 41.45 9.52 62 289189 51194 90288002
Sedation 41.20 9.52 56 289195 48115 90291081
Endometrial cancer stage I 41.18 9.52 19 289232 243 90338953
Metabolic acidosis 40.67 9.52 72 289179 55604 90283592
Skin exfoliation 40.20 9.52 99 289152 67814 90271382
Impaired healing 39.97 9.52 517 288734 233682 90105514
Intentional self-injury 39.77 9.52 22 289229 29312 90309884
Procedural pain 39.77 9.52 29 289222 33331 90305865
Agranulocytosis 39.72 9.52 32 289219 34970 90304226
Hypoglycaemia 39.66 9.52 104 289147 69744 90269452
Weight decreased 39.51 9.52 917 288334 378993 89960203
Confusional state 39.39 9.52 935 288316 385270 89953926
Osteonecrosis of jaw 39.30 9.52 40 289211 39063 90300133
Product label confusion 38.65 9.52 160 289091 22690 90316506
Product dose omission in error 38.59 9.52 9 289242 20494 90318702
Diarrhoea 38.22 9.52 2534 286717 936656 89402540
Small intestine carcinoma stage 0 38.00 9.52 8 289243 0 90339196
Hepatic enzyme 37.69 9.52 64 289187 5280 90333916
Gastrointestinal haemorrhage 37.64 9.52 154 289097 90094 90249102
Thyroxine free increased 37.50 9.52 29 289222 998 90338198
Haemorrhage 37.35 9.52 106 289145 69263 90269933
Urethral cancer 37.06 9.52 9 289242 8 90339188
Lupus vulgaris 36.93 9.52 54 289197 45005 90294191
Crepitations 36.88 9.52 85 289166 8767 90330429
Altered state of consciousness 36.83 9.52 28 289223 31504 90307692
Encephalopathy 36.77 9.52 57 289194 46387 90292809
Oedema peripheral 36.77 9.52 590 288661 257325 90081871
Device difficult to use 36.54 9.52 6 289245 17519 90321677
Cytokine release syndrome 36.47 9.52 22 289229 27951 90311245
Liver disorder 36.35 9.52 232 289019 121037 90218159
Vulval cancer 36.09 9.52 26 289225 802 90338394
Cushingoid 36.04 9.52 93 289158 10302 90328894
Dehydration 35.91 9.52 422 288829 194025 90145171
Prescribed underdose 35.88 9.52 121 289130 74898 90264298
Febrile neutropenia 35.64 9.52 328 288923 158021 90181175
Pneumonia aspiration 35.40 9.52 238 289013 40702 90298494
Gastrointestinal disorder 35.33 9.52 591 288660 256096 90083100
Oropharyngeal oedema 35.06 9.52 19 289232 349 90338847
Hypocholesterolaemia 35.05 9.52 69 289182 6380 90332816
Panniculitis 34.95 9.52 3 289248 14455 90324741
Premature labour 34.94 9.52 108 289143 13268 90325928
Sedation complication 34.89 9.52 6 289245 16938 90322258
Adverse reaction 34.82 9.52 187 289064 29525 90309671
Specific gravity urine decreased 34.45 9.52 25 289226 780 90338416
Neck pain 34.45 9.52 533 288718 113430 90225766
Neuroleptic malignant syndrome 34.23 9.52 4 289247 15092 90324104
Femur fracture 34.20 9.52 59 289192 46023 90293173
Hereditary angioedema 33.73 9.52 85 289166 9280 90329916
Skin haemorrhage 33.69 9.52 13 289238 21367 90317829
Retinitis 33.61 9.52 44 289207 38414 90300782
Pulmonary embolism 33.48 9.52 262 288989 130558 90208638
Pericardial effusion 33.38 9.52 41 289210 36792 90302404
Cells in urine 33.36 9.52 15 289236 180 90339016
Bile duct cancer stage IV 33.25 9.52 7 289244 0 90339196
Tongue carcinoma stage II 33.25 9.52 7 289244 0 90339196
Bone erosion 33.21 9.52 75 289176 52946 90286250
Lupus-like syndrome 33.18 9.52 66 289185 48780 90290416
Device dislocation 33.03 9.52 31 289220 31451 90307745
Walking aid user 32.73 9.52 39 289212 35467 90303729
Synovial cyst 32.68 9.52 97 289154 11655 90327541
Electrocardiogram QT prolonged 32.41 9.52 364 288887 72092 90267104
Hepatic cirrhosis 32.36 9.52 99 289152 63154 90276042
Urinary casts 32.28 9.52 24 289227 778 90338418
Cholestasis 32.27 9.52 41 289210 36258 90302938
Premature delivery 32.22 9.52 46 289205 38716 90300480
Cataract 31.99 9.52 120 289131 71972 90267224
Therapeutic product effect incomplete 31.99 9.52 431 288820 193465 90145731
Affect lability 31.94 9.52 9 289242 18054 90321142
Sense of oppression 31.59 9.52 27 289224 1073 90338123
Adverse event 31.54 9.52 232 289019 117186 90222010
Haematochezia 31.49 9.52 118 289133 70795 90268401
Lip and/or oral cavity cancer 31.43 9.52 25 289226 897 90338299
Pruritus 31.07 9.52 1412 287839 540113 89799083
Herpes zoster 31.03 9.52 176 289075 94468 90244728
Orthostatic hypotension 30.63 9.52 54 289197 41773 90297423
Seronegative arthritis 30.59 9.52 10 289241 18224 90320972
Drug interaction 30.51 9.52 661 288590 275792 90063404
Acute myeloid leukaemia 30.20 9.52 14 289237 20626 90318570
Bone cancer metastatic 30.15 9.52 15 289236 229 90338967
Muscle tension dysphonia 30.07 9.52 16 289235 283 90338913
Colitis 30.02 9.52 118 289133 69824 90269372
Chest discomfort 30.02 9.52 614 288637 137751 90201445
Full blood count abnormal 29.86 9.52 44 289207 36553 90302643
Feeling hot 29.68 9.52 380 288871 77628 90261568
Infusion site reaction 29.64 9.52 130 289121 18909 90320287
Blood thyroid stimulating hormone decreased 29.50 9.52 60 289191 5680 90333516
Contraindicated product administered 29.41 9.52 787 288464 319352 90019844
Inappropriate schedule of product administration 29.40 9.52 321 288930 149612 90189584
Incorrect dose administered 29.40 9.52 383 288868 78547 90260649
Bronchitis 29.36 9.52 329 288922 152598 90186598
Breast disorder 29.26 9.52 40 289211 2727 90336469
Therapy partial responder 29.21 9.52 17 289234 22026 90317170
Creatinine renal clearance decreased 28.95 9.52 12 289239 18887 90320309
Culture urine positive 28.57 9.52 47 289204 3778 90335418
Urine leukocyte esterase 28.55 9.52 13 289238 161 90339035
Dermatitis atopic 28.51 9.52 20 289231 23452 90315744
Nasopharyngeal cancer stage IV 28.50 9.52 6 289245 0 90339196
Prostate cancer stage II 28.50 9.52 6 289245 0 90339196
Anal cancer stage I 28.50 9.52 6 289245 0 90339196
Gallbladder cancer stage 0 28.50 9.52 6 289245 0 90339196
Blood parathyroid hormone decreased 28.30 9.52 3 289248 12213 90326983
Cardiac failure 28.15 9.52 219 289032 109277 90229919
Hypercalcaemia 28.10 9.52 41 289210 34199 90304997
Tri-iodothyronine free increased 28.01 9.52 14 289237 216 90338980
Radiculopathy 27.94 9.52 12 289239 18493 90320703
Female genital tract fistula 27.93 9.52 11 289240 17857 90321339
Surgery 27.70 9.52 64 289187 44823 90294373
Hyponatraemia 27.36 9.52 283 288968 133255 90205941
Blood glucose increased 27.14 9.52 185 289066 95061 90244135
Agitation 27.05 9.52 116 289135 66982 90272214
Device issue 26.64 9.52 33 289218 29504 90309692
Cestode infection 26.59 9.52 15 289236 299 90338897
Fracture 26.56 9.52 19 289232 22057 90317139
Cardiac failure congestive 26.51 9.52 195 289056 98499 90240697
Tonsil cancer 26.46 9.52 15 289236 302 90338894
Subarachnoid haemorrhage 26.42 9.52 12 289239 17892 90321304
Adrenal insufficiency 26.39 9.52 34 289217 29887 90309309
Malignant peritoneal neoplasm 26.32 9.52 21 289230 757 90338439
Proctitis 26.25 9.52 8 289243 15251 90323945
Rash 26.24 9.52 2186 287065 793914 89545282
Maternal exposure timing unspecified 26.21 9.52 20 289231 22463 90316733
Blood pressure inadequately controlled 26.19 9.52 60 289191 6164 90333032
Sopor 26.17 9.52 24 289227 24620 90314576
Cardio-respiratory arrest 26.17 9.52 108 289143 63032 90276164
C-reactive protein abnormal 26.13 9.52 270 288981 127159 90212037
Blister 26.07 9.52 617 288634 254381 90084815
Aspartate aminotransferase increased 25.94 9.52 207 289044 102730 90236466
Lung opacity 25.87 9.52 59 289192 6043 90333153
COVID-19 pneumonia 25.57 9.52 13 289238 18164 90321032
Carcinoid syndrome 25.53 9.52 13 289238 209 90338987
Migraine 25.29 9.52 791 288460 189601 90149595
Band neutrophil percentage increased 25.26 9.52 13 289238 214 90338982
Back pain 25.21 9.52 1246 288005 315929 90023267
Psychotic disorder 25.04 9.52 38 289213 31192 90308004
Haemophagocytic lymphohistiocytosis 25.03 9.52 9 289242 15450 90323746
Injection site swelling 25.02 9.52 102 289149 59737 90279459
Product storage error 24.91 9.52 17 289234 20224 90318972
Carcinoid tumour 24.77 9.52 16 289235 411 90338785
Thyroxine free decreased 24.73 9.52 21 289230 827 90338369
Antinuclear antibody 24.66 9.52 17 289234 488 90338708
Obesity 24.49 9.52 473 288778 105034 90234162
Endometrial cancer stage III 24.36 9.52 6 289245 6 90339190
Arterial occlusive disease 24.36 9.52 5 289246 12441 90326755
Liver function test increased 24.18 9.52 393 288858 84462 90254734
Foot deformity 24.12 9.52 103 289148 59548 90279648
Aphasia 24.11 9.52 64 289187 42748 90296448
X-ray abnormal 24.02 9.52 70 289181 45354 90293842
Food intolerance 23.99 9.52 44 289207 3858 90335338
Renal failure 23.92 9.52 285 288966 130722 90208474
Tongue carcinoma stage III 23.75 9.52 5 289246 0 90339196
Tongue carcinoma stage I 23.75 9.52 5 289246 0 90339196
Injection site pruritus 23.63 9.52 90 289161 53744 90285452
Red blood cells urine 23.58 9.52 17 289234 525 90338671
Cardiogenic shock 23.50 9.52 26 289225 24442 90314754
Hepatic function abnormal 23.28 9.52 73 289178 46215 90292981
Muscle injury 23.24 9.52 410 288841 176244 90162952
Oral pruritus 23.05 9.52 37 289214 2914 90336282
Magnesium deficiency 23.05 9.52 19 289232 718 90338478
Pneumocystis jirovecii pneumonia 23.02 9.52 21 289230 21595 90317601
Photophobia 23.01 9.52 131 289120 21138 90318058
Spinal cord neoplasm 22.90 9.52 15 289236 395 90338801
Abortion induced 22.81 9.52 5 289246 11883 90327313
Ill-defined disorder 22.80 9.52 434 288817 184457 90154739
Prescribed overdose 22.77 9.52 438 288813 97187 90242009
Eye pruritus 22.62 9.52 36 289215 28991 90310205
Skin necrosis 22.54 9.52 13 289238 16928 90322268
Hospitalisation 22.50 9.52 281 288970 127819 90211377
Exposure during pregnancy 22.49 9.52 953 288298 237457 90101739
Reflux gastritis 22.46 9.52 25 289226 1379 90337817
Myocarditis 22.42 9.52 8 289243 13798 90325398
Overlap syndrome 22.31 9.52 69 289182 8479 90330717
Blood creatinine decreased 22.29 9.52 58 289193 6457 90332739
Nasopharyngeal cancer 22.28 9.52 7 289244 27 90339169
Suicidal ideation 22.28 9.52 141 289110 73714 90265482
Decreased immune responsiveness 22.26 9.52 70 289181 8678 90330518
Sleep disorder due to a general medical condition 22.19 9.52 71 289180 44667 90294529
Respiratory depression 22.12 9.52 11 289240 15564 90323632
Anal cancer 22.09 9.52 17 289234 581 90338615
Blood calcium decreased 22.07 9.52 39 289212 30143 90309053
Carbuncle 22.00 9.52 25 289226 1411 90337785
Cellulitis 21.96 9.52 186 289065 91151 90248045
Throat tightness 21.77 9.52 165 289086 29319 90309877
Injury 21.72 9.52 472 288779 196877 90142319
Peripheral swelling 21.72 9.52 1087 288164 412019 89927177
Gangrene 21.71 9.52 7 289244 12869 90326327
Urine oxalate increased 21.69 9.52 12 289239 230 90338966
Liver function test abnormal 21.68 9.52 86 289165 50759 90288437
Cerebral infarction 21.67 9.52 32 289219 26564 90312632
Mean cell haemoglobin concentration increased 21.66 9.52 17 289234 598 90338598
Device malfunction 21.61 9.52 21 289230 20956 90318240
Coronary artery disease 21.52 9.52 47 289204 33576 90305620
Infective pulmonary exacerbation of cystic fibrosis 21.51 9.52 77 289174 10202 90328994
Mast cell activation syndrome 21.50 9.52 26 289225 1568 90337628
Influenza 21.39 9.52 314 288937 138950 90200246
Lip pruritus 21.38 9.52 24 289227 1336 90337860
Acute respiratory failure 21.37 9.52 68 289183 42850 90296346
Breast cancer in situ 21.25 9.52 27 289224 1713 90337483
Gastrointestinal stromal tumour 21.20 9.52 24 289227 1349 90337847
Lymphadenopathy 21.10 9.52 75 289176 45700 90293496
Endometrial cancer stage II 21.03 9.52 6 289245 15 90339181
Injection site urticaria 21.02 9.52 16 289235 17995 90321201
Coagulopathy 21.02 9.52 26 289225 23263 90315933
Vasodilatation 20.95 9.52 35 289216 2849 90336347
Dry skin 20.88 9.52 180 289071 87893 90251303
Aggression 20.85 9.52 33 289218 26635 90312561
Systemic mastocytosis 20.75 9.52 11 289240 193 90339003
Pleural effusion 20.69 9.52 243 289008 111748 90227448
Dislocation of vertebra 20.63 9.52 100 289151 55868 90283328
Pneumonitis 20.61 9.52 72 289179 44098 90295098
Suspected suicide 20.58 9.52 3 289248 9565 90329631
Band neutrophil count increased 20.52 9.52 14 289237 395 90338801
Endocrine ophthalmopathy 20.49 9.52 21 289230 1053 90338143
Subdural haematoma 20.46 9.52 14 289237 16631 90322565
Head injury 20.45 9.52 43 289208 31145 90308051
Myelodysplastic syndrome 20.31 9.52 22 289229 20881 90318315
Myelocyte count increased 20.31 9.52 14 289237 402 90338794
Chronic spontaneous urticaria 20.29 9.52 27 289224 1793 90337403
Seizure 20.15 9.52 354 288897 152275 90186921
Tooth erosion 20.02 9.52 15 289236 492 90338704
Hyperglycaemia 20.01 9.52 89 289162 50881 90288315
Antinuclear antibody positive 20.00 9.52 70 289181 9171 90330025
Neuroendocrine carcinoma 19.96 9.52 13 289238 339 90338857
Cardiomyopathy 19.93 9.52 21 289230 20185 90319011
Bone marrow failure 19.84 9.52 46 289205 32175 90307021
Poisoning 19.79 9.52 12 289239 15205 90323991
Injection site rash 19.78 9.52 29 289222 24144 90315052
Exercise tolerance decreased 19.75 9.52 61 289190 7490 90331706
Transient ischaemic attack 19.73 9.52 71 289180 43105 90296091
Drug dependence 19.60 9.52 40 289211 29287 90309909
International normalised ratio increased 19.57 9.52 81 289170 47235 90291961
Excessive eye blinking 19.53 9.52 23 289228 1349 90337847
Facet joint syndrome 19.52 9.52 431 288820 97958 90241238
Red cell distribution width increased 19.50 9.52 84 289167 12123 90327073
Chest pain 19.42 9.52 828 288423 318817 90020379
Nasal sinus cancer 19.33 9.52 6 289245 22 90339174
Status epilepticus 19.32 9.52 19 289232 18855 90320341
Folliculitis 19.11 9.52 501 288750 203852 90135344
Bladder cancer stage I, without cancer in situ 19.00 9.52 4 289247 0 90339196
Follicular lymphoma stage III 19.00 9.52 4 289247 0 90339196
Epiglottic cancer 19.00 9.52 4 289247 0 90339196
Rectal cancer stage IV 19.00 9.52 4 289247 0 90339196
Cardiac neoplasm malignant 19.00 9.52 4 289247 0 90339196
Motor dysfunction 18.95 9.52 20 289231 19210 90319986
Endometrial cancer 18.86 9.52 38 289213 3574 90335622
Protein urine present 18.81 9.52 57 289194 6927 90332269
Vasculitis 18.79 9.52 27 289224 22666 90316530
Infusion site induration 18.74 9.52 24 289227 1535 90337661
Dyspnoea 18.72 9.52 2495 286756 878460 89460736
Eye disorder 18.61 9.52 37 289214 27353 90311843
Injection site haemorrhage 18.61 9.52 39 289212 28279 90310917
Neoplasm progression 18.49 9.52 76 289175 44410 90294786
Spinal fracture 18.42 9.52 26 289225 21990 90317206
Myelocyte percentage increased 18.39 9.52 10 289241 185 90339011
Neurosis 18.30 9.52 13 289238 392 90338804
Polyarthritis 18.18 9.52 19 289232 18331 90320865
Night sweats 18.17 9.52 539 288712 128227 90210969
Rheumatic fever 18.09 9.52 362 288889 152759 90186437
Pulmonary hypertension 18.08 9.52 72 289179 42451 90296745
Tonsillar haemorrhage 18.07 9.52 11 289240 254 90338942
Hepatotoxicity 18.02 9.52 80 289171 45762 90293434
Cytomegalovirus infection 18.02 9.52 36 289215 26566 90312630
Diabetes mellitus 17.99 9.52 127 289124 64748 90274448
Musculoskeletal disorder 17.93 9.52 26 289225 21743 90317453
Cardiotoxicity 17.82 9.52 7 289244 11382 90327814
Impaired quality of life 17.76 9.52 29 289222 23115 90316081
Respiratory tract infection 17.71 9.52 113 289138 58965 90280231
Splenic neoplasm malignancy unspecified 17.67 9.52 5 289246 12 90339184
Hallucination, auditory 17.64 9.52 15 289236 15960 90323236
Tuberculosis 17.62 9.52 9 289242 12540 90326656
Memory impairment 17.61 9.52 784 288467 196460 90142736
Generalised tonic-clonic seizure 17.59 9.52 55 289196 34848 90304348
Nausea 17.54 9.52 3199 286052 1107117 89232079
Dyskinesia 17.42 9.52 59 289192 36475 90302721
Toxic shock syndrome 17.41 9.52 19 289232 1025 90338171
Gestational diabetes 17.41 9.52 6 289245 10576 90328620
Flank pain 17.38 9.52 113 289138 19109 90320087
Polymenorrhoea 17.33 9.52 22 289229 1395 90337801
Hypothalamo-pituitary disorder 17.26 9.52 28 289223 2224 90336972
Aspiration 17.20 9.52 97 289154 15596 90323600
Rectal cancer metastatic 17.15 9.52 11 289240 279 90338917
Thrombotic microangiopathy 17.12 9.52 15 289236 15728 90323468
Monoclonal immunoglobulin present 17.09 9.52 27 289224 2097 90337099
Respiratory tract congestion 16.98 9.52 39 289212 27371 90311825
Second primary malignancy 16.87 9.52 6 289245 10372 90328824
Bilirubin urine present 16.87 9.52 7 289244 68 90339128
Hemiplegia 16.85 9.52 16 289235 16144 90323052
Foot operation 16.84 9.52 4 289247 8997 90330199
Sickle cell trait 16.77 9.52 4 289247 3 90339193
Irritable bowel syndrome 16.75 9.52 519 288732 206929 90132267
Neuropathy peripheral 16.73 9.52 322 288929 136648 90202548
Platelet count decreased 16.73 9.52 322 288929 136647 90202549
Hypercholesterolaemia 16.68 9.52 431 288820 100461 90238735
Acute hepatic failure 16.64 9.52 29 289222 22532 90316664
Hypomania 16.56 9.52 4 289247 8893 90330303
Frequent bowel movements 16.51 9.52 110 289141 56825 90282371
Staphylococcal infection 16.46 9.52 89 289162 48350 90290846
Pathogen resistance 16.43 9.52 3 289248 8112 90331084
Eczema 16.43 9.52 100 289151 52770 90286426
Mental status changes 16.37 9.52 80 289171 44599 90294597
Breath sounds abnormal 16.32 9.52 15 289236 15371 90323825
Lipaemic index score 16.27 9.52 7 289244 75 90339121
Anuria 16.25 9.52 14 289237 14804 90324392
Injection site bruising 16.22 9.52 99 289152 52208 90286988
Anxiety 16.09 9.52 816 288435 308956 90030240
Vomiting 16.08 9.52 2238 287013 786055 89553141
Infusion site thrombosis 16.06 9.52 9 289242 177 90339019
Enthesopathy 16.05 9.52 5 289246 9399 90329797
Cerebral microhaemorrhage 16.05 9.52 10 289241 241 90338955
Spondylitis 16.04 9.52 13 289238 14165 90325031
Skin fissures 16.03 9.52 26 289225 20783 90318413
Infusion site streaking 16.03 9.52 14 289237 573 90338623
Hypogammaglobulinaemia 15.99 9.52 7 289244 10667 90328529
Cardiac arrest 15.97 9.52 237 289014 104698 90234498
Rectal cancer stage III 15.97 9.52 5 289246 19 90339177
Pelvic fracture 15.95 9.52 15 289236 15204 90323992
Drug effective for unapproved indication 15.88 9.52 3 289248 7915 90331281
Breast calcifications 15.87 9.52 21 289230 1387 90337809
Diffuse large B-cell lymphoma 15.87 9.52 4 289247 8641 90330555
Premenstrual syndrome 15.75 9.52 16 289235 794 90338402
Precancerous condition 15.75 9.52 12 289239 404 90338792
Joint stiffness 15.73 9.52 166 289085 77876 90261320
Osteonecrosis 15.73 9.52 38 289213 26203 90312993
Upper limb fracture 15.67 9.52 28 289223 21550 90317646
Constipation 15.63 9.52 1067 288184 279328 90059868
Interstitial lung disease 15.61 9.52 162 289089 76243 90262953
Product prescribing error 15.55 9.52 47 289204 30098 90309098
Feeling jittery 15.54 9.52 93 289158 15278 90323918
Metastases to liver 15.52 9.52 44 289207 28763 90310433
Anosmia 15.50 9.52 6 289245 9842 90329354
Colon cancer stage 0 15.39 9.52 5 289246 22 90339174
Tenderness 15.38 9.52 142 289109 26726 90312470
Vaginal discharge 15.30 9.52 24 289227 19440 90319756
Exposure via body fluid 15.29 9.52 14 289237 610 90338586
Coordination abnormal 15.25 9.52 28 289223 21328 90317868
Basal cell carcinoma 15.19 9.52 55 289196 33334 90305862
Muscle rigidity 15.12 9.52 14 289237 14295 90324901
Eosinophilia 15.07 9.52 44 289207 28489 90310707
Glomerulonephritis chronic 15.06 9.52 8 289243 141 90339055
Lung disorder 15.01 9.52 603 288648 149280 90189916
Thyroid cancer metastatic 15.01 9.52 8 289243 142 90339054
Product preparation error 14.95 9.52 7 289244 10254 90328942
Intentional dose omission 14.88 9.52 21 289230 17762 90321434
Rhinitis allergic 14.88 9.52 19 289232 16766 90322430
Bacterial infection 14.81 9.52 33 289218 23411 90315785
Foot fracture 14.81 9.52 40 289211 26566 90312630
Laryngitis 14.74 9.52 98 289153 50655 90288541
Hip fracture 14.71 9.52 55 289196 33022 90306174
Product administration interrupted 14.71 9.52 11 289240 12481 90326715
Respiratory disorder 14.69 9.52 134 289117 64682 90274514
Mean cell haemoglobin increased 14.65 9.52 36 289215 3869 90335327
Chronic sinusitis 14.64 9.52 34 289217 23768 90315428
Urobilinogen urine increased 14.60 9.52 10 289241 284 90338912
Acute respiratory distress syndrome 14.60 9.52 45 289206 28641 90310555
Therapy cessation 14.57 9.52 63 289188 36298 90302898
Sarcoma 14.55 9.52 14 289237 650 90338546
Pneumonia viral 14.52 9.52 5 289246 8818 90330378
Product administration error 14.50 9.52 40 289211 26383 90312813
Eosinophil percentage increased 14.44 9.52 17 289234 997 90338199
Splenomegaly 14.43 9.52 12 289239 12912 90326284
Brain neoplasm 14.34 9.52 41 289210 4823 90334373
Breast disorder female 14.34 9.52 8 289243 156 90339040
Bladder cancer recurrent 14.33 9.52 9 289242 220 90338976
Arrhythmia 14.26 9.52 78 289173 42254 90296942
Prostate cancer stage III 14.25 9.52 3 289248 0 90339196
Gastric cancer recurrent 14.25 9.52 3 289248 0 90339196
Rectal cancer stage II 14.25 9.52 3 289248 0 90339196
Endometrial cancer stage IV 14.25 9.52 3 289248 0 90339196
Amastia 14.25 9.52 3 289248 0 90339196
Endocrine neoplasm malignant 14.25 9.52 3 289248 0 90339196
Head and neck cancer stage IV 14.25 9.52 3 289248 0 90339196
Hypervolaemia 14.23 9.52 55 289196 32702 90306494
Rheumatoid arthritis 14.23 9.52 981 288270 361633 89977563
Laryngeal cancer 14.20 9.52 8 289243 159 90339037
Genital haemorrhage 14.20 9.52 5 289246 8697 90330499
Sickle cell anaemia with crisis 14.14 9.52 3 289248 7294 90331902
Respiratory depth decreased 14.12 9.52 5 289246 30 90339166
Cardiac disorder 14.04 9.52 115 289136 56757 90282439
Dysarthria 13.98 9.52 109 289142 54373 90284823
Injection site induration 13.98 9.52 8 289243 10460 90328736
Anti-thyroid antibody positive 13.93 9.52 12 289239 482 90338714
Respiratory arrest 13.79 9.52 57 289194 33254 90305942
Conjunctivitis 13.73 9.52 138 289113 26568 90312628
Liver injury 13.70 9.52 427 288824 170140 90169056
Haematoma 13.68 9.52 71 289180 38977 90300219
Rales 13.68 9.52 92 289159 15735 90323461
Hepatocellular injury 13.64 9.52 47 289204 28911 90310285
Progressive multifocal leukoencephalopathy 13.59 9.52 18 289233 15637 90323559
Leukocyturia 13.58 9.52 21 289230 1601 90337595
Salivary hypersecretion 13.56 9.52 6 289245 9086 90330110
Haematotoxicity 13.56 9.52 12 289239 12523 90326673
Barotrauma 13.52 9.52 8 289243 175 90339021
Clostridium difficile colitis 13.51 9.52 42 289209 26664 90312532
Complication associated with device 13.45 9.52 26 289225 19423 90319773
Device breakage 13.40 9.52 15 289236 14029 90325167
Unintentional medical device removal 13.40 9.52 3 289248 7027 90332169
Pulmonary oedema 13.36 9.52 130 289121 61950 90277246
Lung cancer metastatic 13.30 9.52 29 289222 2882 90336314
White blood cell count increased 13.16 9.52 144 289107 67097 90272099
Red blood cell count increased 13.05 9.52 33 289218 3610 90335586
Organising pneumonia 13.04 9.52 4 289247 7593 90331603
Nail avulsion 12.99 9.52 10 289241 342 90338854
Dystonia 12.97 9.52 21 289230 16798 90322398
Rectal cancer 12.97 9.52 25 289226 2276 90336920
Jaundice cholestatic 12.95 9.52 8 289243 10035 90329161
Extrapyramidal disorder 12.91 9.52 20 289231 16283 90322913
Transplant rejection 12.88 9.52 13 289238 12745 90326451
Exostosis 12.86 9.52 108 289143 53026 90286170
Overflow diarrhoea 12.80 9.52 7 289244 131 90339065
Demyelination 12.74 9.52 5 289246 8135 90331061
Emphysema 12.72 9.52 12 289239 12143 90327053
Pancreatitis 12.70 9.52 152 289099 69674 90269522
Post procedural complication 12.70 9.52 26 289225 19016 90320180
Nasal ulcer 12.69 9.52 27 289224 2639 90336557
Amnesia 12.67 9.52 257 288994 108248 90230948
Thyroid stimulating immunoglobulin increased 12.66 9.52 7 289244 134 90339062
Enterocolitis 12.66 9.52 9 289242 10481 90328715
Bile duct cancer 12.65 9.52 13 289238 654 90338542
Pharyngeal swelling 12.63 9.52 64 289187 9880 90329316
Diabetic ketoacidosis 12.62 9.52 38 289213 24369 90314827
Crystalluria 12.60 9.52 12 289239 550 90338646
Product substitution issue 12.52 9.52 24 289227 17984 90321212
Live birth 12.51 9.52 336 288915 78771 90260425
Tryptase increased 12.51 9.52 12 289239 555 90338641
Back disorder 12.49 9.52 41 289210 25590 90313606
Blood creatine phosphokinase increased 12.41 9.52 61 289190 33962 90305234
Glycosylated haemoglobin increased 12.41 9.52 19 289232 15543 90323653
Rib fracture 12.39 9.52 43 289208 26392 90312804
Immunisation reaction 12.38 9.52 14 289237 786 90338410
Palmar erythema 12.32 9.52 22 289229 1889 90337307
Vascular device infection 12.27 9.52 12 289239 11940 90327256
Nephrolithiasis 12.23 9.52 99 289152 48986 90290210
Blood calcium increased 12.22 9.52 73 289178 11985 90327211
C-kit gene mutation 12.18 9.52 3 289248 3 90339193
Endocrine neoplasm 12.18 9.52 3 289248 3 90339193
Pituitary apoplexy 12.17 9.52 7 289244 145 90339051
Hospice care 12.14 9.52 8 289243 9696 90329500
Uveitis 12.13 9.52 20 289231 15883 90323313
Bronchospasm 12.13 9.52 110 289141 20599 90318597
Bruxism 12.12 9.52 36 289215 4327 90334869
Escherichia infection 12.12 9.52 20 289231 15875 90323321
Renal pain 12.09 9.52 53 289198 7706 90331490
Abdominal distension 12.07 9.52 521 288730 130080 90209116
Intestinal metaplasia 12.07 9.52 4 289247 19 90339177
Malignant anorectal neoplasm 12.07 9.52 4 289247 19 90339177
Shock 12.06 9.52 49 289202 28729 90310467
Palpitations 12.05 9.52 338 288913 136390 90202806
Lip dry 12.00 9.52 414 288837 100541 90238655
Oligohydramnios 11.99 9.52 4 289247 7197 90331999
Pain in extremity 11.95 9.52 1257 287994 449272 89889924
Urethral pain 11.86 9.52 10 289241 390 90338806
Spinal fusion surgery 11.85 9.52 13 289238 12270 90326926
Hypokalaemia 11.84 9.52 323 288928 130793 90208403
Pneumonia bacterial 11.84 9.52 14 289237 12776 90326420
Hypoaesthesia 11.76 9.52 1160 288091 313050 90026146
Grip strength 11.76 9.52 7 289244 8958 90330238
Productive cough 11.74 9.52 174 289077 76889 90262307
Malignant neoplasm of renal pelvis 11.74 9.52 4 289247 21 90339175
Infusion site haemorrhage 11.72 9.52 41 289210 5370 90333826
Leiomyosarcoma 11.72 9.52 8 289243 226 90338970
Intentional product use issue 11.71 9.52 569 288682 216323 90122873
Joint injury 11.67 9.52 59 289192 32605 90306591
Vaginal cancer 11.66 9.52 9 289242 309 90338887
Nephropathy toxic 11.63 9.52 14 289237 12674 90326522
Miosis 11.63 9.52 8 289243 9476 90329720
Persistent depressive disorder 11.56 9.52 17 289234 1240 90337956
Cytopenia 11.49 9.52 24 289227 17425 90321771
Myositis 11.48 9.52 39 289212 24089 90315107
Unintended pregnancy 11.46 9.52 5 289246 7632 90331564
Vaginal haemorrhage 11.45 9.52 56 289195 31215 90307981
Malignant melanoma stage IV 11.44 9.52 4 289247 23 90339173
Parkinsonism 11.38 9.52 17 289234 14048 90325148
Gastroenteritis bacterial 11.38 9.52 10 289241 413 90338783
Right ventricular failure 11.36 9.52 28 289223 19177 90320019
Pulmonary arterial hypertension 11.35 9.52 44 289207 26143 90313053
Lymphorrhoea 11.35 9.52 5 289246 57 90339139
Sinus disorder 11.32 9.52 64 289187 34383 90304813
Macroglossia 11.31 9.52 14 289237 865 90338331
Paranasal sinus inflammation 11.31 9.52 12 289239 627 90338569
Anisomastia 11.30 9.52 4 289247 24 90339172
Dyschromatopsia 11.29 9.52 13 289238 744 90338452
Bone disorder 11.25 9.52 37 289214 23083 90316113
Melaena 11.24 9.52 65 289186 34732 90304464
Sleep disorder 11.19 9.52 517 288734 197513 90141683
Angina pectoris 11.18 9.52 76 289175 39084 90300112
Specific gravity urine increased 11.13 9.52 8 289243 246 90338950
Ischaemic stroke 11.12 9.52 35 289216 22131 90317065
Invasive lobular breast carcinoma 11.07 9.52 15 289236 1014 90338182
Ankle fracture 11.06 9.52 31 289220 20339 90318857
Pulmonary thrombosis 11.03 9.52 9 289242 9773 90329423
Visual acuity reduced 11.03 9.52 38 289213 23372 90315824
Pustular psoriasis 11.02 9.52 27 289224 18529 90320667
Blood thyroid stimulating hormone increased 10.99 9.52 58 289193 9097 90330099
Glaucoma 10.96 9.52 32 289219 20723 90318473
Aspergillus infection 10.96 9.52 11 289240 10812 90328384
Monocyte count decreased 10.93 9.52 25 289226 2566 90336630
Porphyria acute 10.79 9.52 26 289225 17949 90321247
Optic neuritis 10.73 9.52 60 289191 9618 90329578
Pain of skin 10.69 9.52 22 289229 16060 90323136
General symptom 10.68 9.52 19 289232 14649 90324547
Localised infection 10.68 9.52 63 289188 33499 90305697
Syncope 10.68 9.52 332 288919 132331 90206865
Cervix disorder 10.68 9.52 12 289239 669 90338527
Maternal exposure before pregnancy 10.68 9.52 12 289239 11201 90327995
Varicose vein 10.67 9.52 5 289246 7322 90331874
Malignant splenic neoplasm 10.66 9.52 3 289248 7 90339189
Infusion site pain 10.64 9.52 103 289148 19635 90319561
Malaise 10.63 9.52 1675 287576 584311 89754885
Hyperreflexia 10.57 9.52 4 289247 6653 90332543
Akathisia 10.56 9.52 12 289239 11147 90328049
Pemphigoid 10.56 9.52 8 289243 9018 90330178
Nasal congestion 10.52 9.52 195 289056 83219 90255977
Labelled drug-drug interaction medication error 10.52 9.52 19 289232 14563 90324633
Encephalitis 10.51 9.52 12 289239 11122 90328074
White blood cells urine 10.51 9.52 10 289241 458 90338738
Incorrect route of product administration 10.48 9.52 107 289144 50519 90288677
Hepatic steatosis 10.48 9.52 171 289080 36774 90302422
HER2 positive breast cancer 10.47 9.52 10 289241 460 90338736
Hepatic failure 10.42 9.52 79 289172 39649 90299547
Ureteric cancer 10.37 9.52 5 289246 71 90339125
Salivary gland cancer 10.37 9.52 7 289244 194 90339002
Immunosuppression 10.37 9.52 14 289237 12063 90327133
Cerebral haemorrhage 10.36 9.52 66 289185 34456 90304740
Gait inability 10.33 9.52 569 288682 145887 90193309
Thyroid stimulating immunoglobulin 10.31 9.52 5 289246 72 90339124
Influenza like illness 10.31 9.52 188 289063 80423 90258773
Pneumococcal infection 10.26 9.52 16 289235 1229 90337967
Ascites 10.26 9.52 100 289151 47640 90291556
Hypoaesthesia oral 10.25 9.52 85 289166 15515 90323681
Hypertransaminasaemia 10.23 9.52 22 289229 15803 90323393
Ovarian hyperstimulation syndrome 10.22 9.52 3 289248 5859 90333337
Blood alkaline phosphatase increased 10.21 9.52 101 289150 47978 90291218
Needle issue 10.19 9.52 18 289233 13916 90325280
Wrong technique in device usage process 10.15 9.52 3 289248 5832 90333364
Insurance issue 10.14 9.52 12 289239 10946 90328250
Rebound effect 10.13 9.52 9 289242 9375 90329821
Lobular breast carcinoma in situ 10.13 9.52 5 289246 75 90339121
Psoriatic arthropathy 10.10 9.52 611 288640 227724 90111472
Drug level below therapeutic 10.09 9.52 3 289248 5811 90333385
Cardiac failure acute 10.07 9.52 14 289237 11915 90327281
Intentional product misuse 10.04 9.52 365 288886 89239 90249957
Delusion 10.01 9.52 18 289233 13822 90325374
Unresponsive to stimuli 9.91 9.52 76 289175 38045 90301151
Oropharyngeal spasm 9.89 9.52 8 289243 294 90338902
Full blood count decreased 9.84 9.52 55 289196 29634 90309562
Klebsiella infection 9.83 9.52 11 289240 10286 90328910
Muscle tightness 9.80 9.52 75 289176 13364 90325832
Hypothermia 9.78 9.52 22 289229 15553 90323643
Junctional ectopic tachycardia 9.77 9.52 7 289244 214 90338982
Joint range of motion decreased 9.77 9.52 528 288723 135115 90204081
Respiratory acidosis 9.75 9.52 7 289244 8112 90331084
Laryngospasm 9.74 9.52 28 289223 3305 90335891
Retinal depigmentation 9.73 9.52 8 289243 301 90338895
Retinal artery embolism 9.73 9.52 5 289246 82 90339114
Joint effusion 9.73 9.52 101 289150 19609 90319587
Blood creatine phosphokinase MM increased 9.72 9.52 4 289247 38 90339158
Metastases to lung 9.71 9.52 23 289228 15968 90323228
Metamorphopsia 9.69 9.52 17 289234 1440 90337756
Fumbling 9.69 9.52 6 289245 143 90339053
Dermatitis allergic 9.68 9.52 26 289225 17301 90321895
Breast cancer recurrent 9.68 9.52 39 289212 5464 90333732
Polycystic ovaries 9.66 9.52 3 289248 5651 90333545
Tooth abscess 9.65 9.52 24 289227 16389 90322807
Acquired epidermolysis bullosa 9.63 9.52 4 289247 39 90339157
Renal tubular necrosis 9.60 9.52 20 289231 14535 90324661
Therapeutic response shortened 9.56 9.52 39 289212 22840 90316356

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Prostate cancer 42420.04 11.21 12411 138406 32232 42438286
Bladder cancer 25247.72 11.21 6738 144079 10309 42460209
Oesophageal carcinoma 20442.80 11.21 5083 145734 4613 42465905
Renal cancer 15562.36 11.21 3957 146860 4267 42466251
Colorectal cancer 14868.08 11.21 3468 147349 1570 42468948
Prostate cancer stage I 11521.90 11.21 2500 148317 121 42470397
Prostate cancer stage IV 10290.70 11.21 2266 148551 274 42470244
Prostate cancer stage II 9283.25 11.21 2041 148776 229 42470289
Colorectal cancer stage III 8439.98 11.21 1816 149001 11 42470507
Prostate cancer stage III 8102.03 11.21 1750 149067 42 42470476
Colorectal cancer stage IV 7584.34 11.21 1630 149187 0 42470518
Hepatic cancer stage IV 6541.03 11.21 1406 149411 0 42470518
Gastric cancer 5525.12 11.21 1695 149122 5208 42465310
Hepatic cancer 5503.29 11.21 1774 149043 6706 42463812
Renal cancer stage IV 4982.18 11.21 1075 149742 18 42470500
Pancreatic carcinoma stage IV 4733.03 11.21 1041 149776 115 42470403
Colorectal cancer stage II 4706.73 11.21 1012 149805 0 42470518
Renal cancer stage I 4273.79 11.21 923 149894 19 42470499
Gastric cancer stage IV 3961.28 11.21 855 149962 15 42470503
Bladder cancer stage II 3781.77 11.21 816 150001 13 42470505
Pancreatic carcinoma 3707.24 11.21 1359 149458 8147 42462371
Bladder cancer stage IV 3552.68 11.21 764 150053 0 42470518
Renal cancer stage III 3247.72 11.21 701 150116 12 42470506
Testis cancer 3206.10 11.21 800 150017 726 42469792
Colorectal cancer stage I 3203.75 11.21 689 150128 0 42470518
Lung carcinoma cell type unspecified stage IV 3094.62 11.21 742 150075 459 42470059
Renal cancer stage II 3073.49 11.21 661 150156 0 42470518
Gastrointestinal carcinoma 2899.19 11.21 776 150041 1170 42469348
Bladder cancer stage III 2892.07 11.21 622 150195 0 42470518
Prostate cancer stage 0 1813.06 11.21 390 150427 0 42470518
Lung neoplasm malignant 1797.70 11.21 1013 149804 18134 42452384
Gastric cancer stage I 1789.81 11.21 385 150432 0 42470518
Skin cancer 1754.50 11.21 842 149975 10620 42459898
Gastric cancer stage III 1559.51 11.21 338 150479 12 42470506
Haematological malignancy 1488.14 11.21 356 150461 214 42470304
Gastric cancer stage II 1352.73 11.21 291 150526 0 42470518
Pancreatic carcinoma stage II 1176.05 11.21 253 150564 0 42470518
Throat cancer 1161.53 11.21 356 150461 1083 42469435
Brain neoplasm malignant 1103.62 11.21 311 150506 630 42469888
Neoplasm malignant 1069.19 11.21 778 150039 21965 42448553
Thyroid cancer 1066.29 11.21 351 150466 1432 42469086
Pancreatic carcinoma stage III 1065.93 11.21 231 150586 8 42470510
Hepatic cancer stage III 943.60 11.21 203 150614 0 42470518
Lung carcinoma cell type unspecified stage I 938.52 11.21 204 150613 10 42470508
Lung carcinoma cell type unspecified stage III 883.16 11.21 190 150627 0 42470518
Drug ineffective 799.55 11.21 640 150177 629557 41840961
Pancreatic carcinoma stage I 790.18 11.21 170 150647 0 42470518
Hepatic cancer stage II 743.70 11.21 160 150657 0 42470518
Hepatic cancer stage I 729.75 11.21 157 150660 0 42470518
Off label use 690.64 11.21 749 150068 637586 41832932
Bone cancer 608.50 11.21 234 150583 1625 42468893
Lung carcinoma cell type unspecified stage II 562.41 11.21 121 150696 0 42470518
Breast cancer male 491.78 11.21 140 150677 299 42470219
Death 454.81 11.21 603 150214 470582 41999936
Appendix cancer 435.75 11.21 95 150722 6 42470512
Disease progression 432.99 11.21 1302 149515 142354 42328164
Bladder cancer stage I, with cancer in situ 381.12 11.21 82 150735 0 42470518
Small intestine carcinoma 379.89 11.21 127 150690 549 42469969
Prostatic disorder 361.75 11.21 201 150616 3488 42467030
Breast cancer stage I 348.59 11.21 75 150742 0 42470518
Thyroid cancer stage IV 343.94 11.21 74 150743 0 42470518
Thyroid cancer stage I 330.00 11.21 71 150746 0 42470518
Breast cancer stage II 320.70 11.21 69 150748 0 42470518
Toxicity to various agents 311.60 11.21 215 150602 228921 42241597
Small intestine carcinoma stage IV 311.40 11.21 67 150750 0 42470518
Colon cancer stage IV 245 11.21 71 150746 166 42470352
Condition aggravated 222.09 11.21 363 150454 260391 42210127
Diarrhoea 220.52 11.21 863 149954 459986 42010532
Colorectal carcinoma stage 0 218.44 11.21 47 150770 0 42470518
Breast cancer stage III 218.44 11.21 47 150770 0 42470518
Acute kidney injury 213.59 11.21 632 150185 366705 42103813
Gallbladder cancer 211.67 11.21 66 150751 216 42470302
Gastric cancer stage 0 203.18 11.21 46 150771 12 42470506
Colon cancer 201.52 11.21 208 150609 9473 42461045
Breast cancer stage IV 199.85 11.21 43 150774 0 42470518
Thyroid cancer stage II 195.20 11.21 42 150775 0 42470518
Thyroid cancer stage III 195.20 11.21 42 150775 0 42470518
Colon cancer stage III 190.90 11.21 56 150761 139 42470379
Dyspnoea 189.93 11.21 864 149953 441757 42028761
Product use in unapproved indication 189.75 11.21 224 150593 184232 42286286
Anaemia 189.53 11.21 447 150370 279831 42190687
Pneumonia 181.09 11.21 824 149993 421325 42049193
Nasal cavity cancer 179.23 11.21 55 150762 168 42470350
Drug interaction 169.39 11.21 440 150377 266559 42203959
Small intestine carcinoma stage III 167.32 11.21 36 150781 0 42470518
Fatigue 166.85 11.21 885 149932 434756 42035762
Pyrexia 164.86 11.21 776 150041 393266 42077252
Completed suicide 162.28 11.21 69 150748 96396 42374122
General physical health deterioration 160.56 11.21 179 150638 151067 42319451
Nausea 156.42 11.21 798 150019 396001 42074517
Cardiac failure 156.35 11.21 92 150725 106764 42363754
Uterine cancer 153.37 11.21 33 150784 0 42470518
Colon cancer stage II 153.21 11.21 40 150777 51 42470467
Fall 150.60 11.21 384 150433 234136 42236382
Lymphoma 149.39 11.21 217 150600 14104 42456414
Arthralgia 148.68 11.21 315 150502 204923 42265595
Sepsis 148.57 11.21 301 150516 199033 42271485
Drug abuse 148.00 11.21 94 150723 104677 42365841
Drug intolerance 141.01 11.21 54 150763 80370 42390148
Colon cancer stage I 140.83 11.21 32 150785 9 42470509
Gallbladder cancer stage IV 139.43 11.21 30 150787 0 42470518
Febrile neutropenia 137.88 11.21 281 150536 185422 42285096
Tongue carcinoma stage IV 134.78 11.21 29 150788 0 42470518
Multiple organ dysfunction syndrome 127.79 11.21 94 150723 96941 42373577
COVID-19 124.37 11.21 136 150681 115812 42354706
Adrenal gland cancer 122.05 11.21 32 150785 42 42470476
Rash 118.82 11.21 540 150277 276414 42194104
Treatment failure 111.53 11.21 41 150776 62583 42407935
Malignant neoplasm progression 110.98 11.21 132 150685 108268 42362250
Tongue neoplasm malignant stage unspecified 109.03 11.21 55 150762 776 42469742
Disability 108.48 11.21 119 150698 5814 42464704
Vomiting 108.18 11.21 593 150224 289130 42181388
Asthenia 108.01 11.21 569 150248 280224 42190294
Product dose omission issue 105.90 11.21 244 150573 154121 42316397
Neutropenia 105.14 11.21 358 150459 199073 42271445
Lung carcinoma cell type unspecified stage 0 105.03 11.21 28 150789 41 42470477
Pancytopenia 104.69 11.21 159 150658 117584 42352934
Suicide attempt 103.34 11.21 19 150798 46081 42424437
Incorrect dose administered 103.25 11.21 416 150401 52558 42417960
Lip and/or oral cavity cancer 99.24 11.21 43 150774 419 42470099
Cytokine release syndrome 98.43 11.21 19 150798 44508 42426010
Small intestine carcinoma stage I 97.60 11.21 21 150796 0 42470518
Small intestine carcinoma stage II 97.60 11.21 21 150796 0 42470518
Interstitial lung disease 96.99 11.21 81 150736 78381 42392137
Pain in extremity 95.48 11.21 248 150569 150356 42320162
Loss of personal independence in daily activities 95.01 11.21 29 150788 49787 42420731
Oedema peripheral 94.20 11.21 214 150603 135862 42334656
Pulmonary embolism 93.02 11.21 176 150641 119436 42351082
Oesophageal carcinoma stage 0 92.95 11.21 20 150797 0 42470518
Hypotension 91.97 11.21 535 150282 257096 42213422
Drug ineffective for unapproved indication 91.49 11.21 25 150792 46138 42424380
Drug resistance 91.49 11.21 8 150809 34240 42436278
Somnolence 90.49 11.21 231 150586 140874 42329644
Intentional product use issue 90.22 11.21 73 150744 71760 42398758
Myelosuppression 90.00 11.21 17 150800 40444 42430074
Respiratory failure 89.10 11.21 201 150616 127931 42342587
Anhedonia 88.91 11.21 122 150695 7518 42463000
Weight decreased 88.77 11.21 406 150411 207542 42262976
Tongue carcinoma stage III 88.31 11.21 19 150798 0 42470518
Pancreatic carcinoma stage 0 88.31 11.21 19 150798 0 42470518
Dizziness 86.10 11.21 523 150294 248731 42221787
Leukaemia 85.72 11.21 104 150713 5668 42464850
Thyroid cancer stage 0 83.66 11.21 18 150799 0 42470518
Thrombocytopenia 82.70 11.21 369 150448 189910 42280608
Joint swelling 81.90 11.21 72 150745 67950 42402568
Hepatic cytolysis 81.65 11.21 3 150814 26841 42443677
Injection site pain 80.03 11.21 53 150764 57745 42412773
Laryngeal cancer stage I 79.01 11.21 17 150800 0 42470518
Coma 78.45 11.21 46 150771 53508 42417010
Septic shock 78.42 11.21 127 150690 91545 42378973
Peripheral swelling 78.22 11.21 124 150693 90146 42380372
Renal impairment 77.38 11.21 172 150645 110056 42360462
Atrial fibrillation 77.37 11.21 245 150572 139348 42331170
Rheumatoid arthritis 76.90 11.21 27 150790 42413 42428105
Pain 74.83 11.21 533 150284 244315 42226203
Bladder cancer recurrent 74.30 11.21 34 150783 381 42470137
Therapeutic product effect incomplete 72.99 11.21 86 150731 70853 42399665
Laryngeal cancer 71.73 11.21 40 150777 699 42469819
Reversible airways obstruction 70.70 11.21 37 150780 566 42469952
Pleural effusion 70.36 11.21 149 150668 97017 42373501
Tongue carcinoma stage II 69.71 11.21 15 150802 0 42470518
Cerebrovascular accident 69.51 11.21 150 150667 97010 42373508
Tonsil cancer 69.23 11.21 46 150771 1115 42469403
Decreased appetite 67.83 11.21 403 150414 192734 42277784
Lactic acidosis 67.54 11.21 38 150779 45223 42425295
Myocardial infarction 66.38 11.21 221 150596 123788 42346730
Depression 66.33 11.21 189 150628 111174 42359344
Intentional overdose 66.23 11.21 51 150766 51405 42419113
Rhabdomyolysis 65.87 11.21 109 150708 77910 42392608
Weight increased 65.25 11.21 182 150635 107801 42362717
Headache 65.16 11.21 538 150279 238831 42231687
Gait disturbance 63.13 11.21 160 150657 97840 42372678
Overdose 62.43 11.21 179 150638 105085 42365433
Malaise 62.30 11.21 467 150350 211689 42258829
Myalgia 61.79 11.21 157 150660 95923 42374595
Drug hypersensitivity 61.18 11.21 166 150651 99223 42371295
Laryngeal cancer stage IV 60.94 11.21 15 150802 12 42470506
Hepatic cancer metastatic 60.39 11.21 37 150780 776 42469742
Infection 59.79 11.21 200 150617 111868 42358650
Confusional state 59.74 11.21 348 150469 167249 42303269
Hepatic function abnormal 59.20 11.21 57 150760 51510 42419008
Bone cancer metastatic 58.65 11.21 24 150793 200 42470318
Therapy non-responder 57.82 11.21 62 150755 53297 42417221
Haematochezia 56.80 11.21 74 150743 58362 42412156
Thrombosis 56.65 11.21 97 150720 68414 42402104
Tremor 55.90 11.21 167 150650 96762 42373756
Head and neck cancer stage IV 55.77 11.21 12 150805 0 42470518
Cardiac failure congestive 55.72 11.21 139 150678 85463 42385055
Therapeutic product effect decreased 55.42 11.21 35 150782 39115 42431403
Accidental exposure to product 53.83 11.21 5 150812 20388 42450130
Clear cell renal cell carcinoma 53.83 11.21 41 150776 1240 42469278
Blood cholesterol 53.73 11.21 23 150794 217 42470301
Encephalopathy 53.15 11.21 41 150776 41292 42429226
Cardiac arrest 53.05 11.21 203 150614 109117 42361401
Ascites 52.83 11.21 74 150743 56604 42413914
COVID-19 pneumonia 52.76 11.21 7 150810 21606 42448912
Hyponatraemia 52.13 11.21 184 150633 101278 42369240
Constipation 52.13 11.21 348 150469 161943 42308575
Victim of child abuse 52.05 11.21 39 150778 1150 42469368
Accidental overdose 51.36 11.21 18 150799 28312 42442206
Inappropriate schedule of product administration 51.25 11.21 171 150646 95731 42374787
Gallbladder cancer stage I 51.12 11.21 11 150806 0 42470518
Tongue carcinoma stage I 51.12 11.21 11 150806 0 42470518
Hyperkalaemia 50.55 11.21 133 150684 80325 42390193
Oesophageal cancer metastatic 50.43 11.21 25 150792 339 42470179
Dry skin 50.36 11.21 58 150759 48280 42422238
Hypokalaemia 50.24 11.21 112 150705 71609 42398909
Muscular weakness 50.23 11.21 141 150676 83357 42387161
Back pain 50.18 11.21 295 150522 141481 42329037
Dehydration 50.17 11.21 295 150522 141472 42329046
No adverse event 49.80 11.21 39 150778 38982 42431536
Sleep disorder due to a general medical condition 49.70 11.21 3 150814 17450 42453068
Epidural lipomatosis 49.36 11.21 45 150772 1755 42468763
Urethral cancer 49.35 11.21 17 150800 82 42470436
Deep vein thrombosis 49.28 11.21 126 150691 76831 42393687
Delusion of grandeur 49.15 11.21 47 150770 1949 42468569
Hypoxia 48.86 11.21 109 150708 69677 42400841
Renal failure 48.28 11.21 304 150513 143422 42327096
Blood pressure decreased 47.85 11.21 83 150734 58249 42412269
Deformity 47.79 11.21 42 150775 1560 42468958
Alanine aminotransferase increased 47.67 11.21 157 150660 88249 42382269
Cough 47.65 11.21 402 150415 177701 42292817
Altered state of consciousness 47.48 11.21 22 150795 29237 42441281
Hyperhidrosis 47.26 11.21 163 150654 90349 42380169
C-reactive protein increased 47.24 11.21 96 150721 63464 42407054
Shock 47.10 11.21 22 150795 29099 42441419
Psoriatic arthropathy 46.77 11.21 15 150802 24952 42445566
Cardio-respiratory arrest 46.68 11.21 85 150732 58551 42411967
Pruritus 46.58 11.21 435 150382 188336 42282182
Neuroendocrine carcinoma 46.23 11.21 27 150790 517 42470001
Suicidal ideation 45.77 11.21 62 150755 48099 42422419
Muscle spasms 45.58 11.21 154 150663 85890 42384628
Hepatic enzyme increased 45.50 11.21 57 150760 45727 42424791
Syncope 45.44 11.21 189 150628 99217 42371301
Sedation 44.87 11.21 26 150791 30449 42440069
Hypertension 44.45 11.21 378 150439 166826 42303692
Metabolic acidosis 44.18 11.21 72 150745 51786 42418732
Abdominal pain 44.01 11.21 446 150371 190025 42280493
Blood creatinine increased 43.81 11.21 220 150597 109783 42360735
Cerebral haemorrhage 43.65 11.21 44 150773 38922 42431596
Chronic obstructive pulmonary disease 43.03 11.21 100 150717 63014 42407504
Vertigo 42.99 11.21 35 150782 34312 42436206
Child abuse 42.98 11.21 31 150786 861 42469657
Epistaxis 42.33 11.21 110 150707 66716 42403802
Gallbladder cancer stage III 41.83 11.21 9 150808 0 42470518
Hypoglycaemia 41.48 11.21 94 150723 59760 42410758
Incorrect route of product administration 41.46 11.21 17 150800 24288 42446230
Stress 40.93 11.21 58 150759 44154 42426364
Rhinalgia 40.88 11.21 41 150776 1803 42468715
Pulmonary alveolar haemorrhage 40.85 11.21 3 150814 14813 42455705
Synovitis 40.60 11.21 4 150813 15563 42454955
Blood glucose increased 40.34 11.21 130 150687 73569 42396949
Therapeutic response decreased 40.10 11.21 43 150774 36969 42433549
Laryngeal cancer stage III 40.09 11.21 10 150807 9 42470509
Neuroleptic malignant syndrome 40.04 11.21 13 150804 21459 42449059
Foetal exposure during pregnancy 40.01 11.21 66 150751 47245 42423273
Juvenile idiopathic arthritis 39.92 11.21 48 150769 2591 42467927
Neuropathy peripheral 39.82 11.21 205 150612 101648 42368870
Drug-induced liver injury 39.79 11.21 46 150771 38227 42432291
Brain cancer metastatic 39.77 11.21 16 150801 127 42470391
Eosinophilia 39.37 11.21 35 150782 32864 42437654
Therapy partial responder 39.37 11.21 11 150806 20010 42450508
Psoriasis 39.10 11.21 70 150747 48534 42421984
Aspartate aminotransferase increased 38.92 11.21 141 150676 77022 42393496
Disease recurrence 38.72 11.21 29 150788 29649 42440869
Blood creatine phosphokinase increased 38.54 11.21 70 150747 48268 42422250
Palpitations 38.36 11.21 76 150741 50721 42419797
Abnormal behaviour 38.33 11.21 23 150794 26428 42444090
Malignant neoplasm of spinal cord 38.17 11.21 11 150806 25 42470493
Obstructive airways disorder 38.08 11.21 20 150797 24739 42445779
Appendicitis 37.53 11.21 13 150804 20600 42449918
Therapy interrupted 37.25 11.21 16 150801 22234 42448284
Arthropathy 37.24 11.21 30 150787 29567 42440951
Ischaemic stroke 37.20 11.21 16 150801 22217 42448301
Rectal cancer stage III 37.18 11.21 8 150809 0 42470518
Lymphocyte count abnormal 36.78 11.21 42 150775 2145 42468373
Nasopharyngeal cancer 36.05 11.21 15 150802 131 42470387
Nightmare 35.90 11.21 22 150795 24990 42445528
Musculoskeletal stiffness 35.89 11.21 96 150721 57669 42412849
Acute myocardial infarction 35.89 11.21 97 150720 58068 42412450
Shock haemorrhagic 35.74 11.21 7 150810 16235 42454283
Memory impairment 35.52 11.21 78 150739 50144 42420374
Ureteric cancer 35.41 11.21 17 150800 214 42470304
Arrhythmia 35.27 11.21 55 150762 40262 42430256
Hypoaesthesia 35.11 11.21 132 150685 71331 42399187
Neurotoxicity 35.08 11.21 20 150797 23631 42446887
Bladder cancer stage 0, with cancer in situ 35.05 11.21 11 150806 37 42470481
Oedema 34.96 11.21 83 150734 51918 42418600
Neuralgia 34.85 11.21 24 150793 25623 42444895
Visual impairment 34.76 11.21 62 150755 43051 42427467
Transaminases increased 34.75 11.21 39 150778 32846 42437672
Seizure 34.57 11.21 267 150550 120294 42350224
Haemoglobin decreased 34.51 11.21 301 150516 132170 42338348
Aspergillus infection 34.49 11.21 7 150810 15830 42454688
Myocarditis 34.38 11.21 12 150805 18926 42451592
Gastrointestinal stromal tumour 34.28 11.21 30 150787 1108 42469410
Chest pain 34.19 11.21 322 150495 139208 42331310
Intentional product misuse 34.01 11.21 109 150708 61791 42408727
Fluid retention 33.96 11.21 37 150780 31582 42438936
Contraindicated product administered 33.87 11.21 24 150793 25248 42445270
Urinary tract infection 33.84 11.21 209 150608 99075 42371443
Sleep disorder 33.76 11.21 75 150742 48020 42422498
Haemorrhage 33.72 11.21 106 150711 60457 42410061
Balance disorder 33.69 11.21 74 150743 47571 42422947
Hepatic failure 33.30 11.21 52 150765 38048 42432470
Rectal cancer stage II 32.53 11.21 7 150810 0 42470518
Tongue cancer metastatic 32.53 11.21 7 150810 0 42470518
Bladder cancer stage I, without cancer in situ 32.53 11.21 7 150810 0 42470518
Cytomegalovirus infection 32.33 11.21 40 150777 32266 42438252
Bradycardia 32.32 11.21 174 150643 85310 42385208
Cerebral infarction 31.82 11.21 38 150779 31131 42439387
Arthritis 31.71 11.21 63 150754 42002 42428516
Vision blurred 31.32 11.21 92 150725 53607 42416911
Pulmonary oedema 31.26 11.21 91 150726 53181 42417337
Vasculitis 31.16 11.21 13 150804 18381 42452137
Liver disorder 31.08 11.21 58 150759 39586 42430932
Full blood count abnormal 30.95 11.21 36 150781 29840 42440678
Tinnitus 30.93 11.21 34 150783 28904 42441614
Haemoptysis 30.79 11.21 74 150743 46093 42424425
Platelet count decreased 30.56 11.21 328 150489 138253 42332265
Sopor 30.55 11.21 5 150812 13197 42457321
White blood cell count decreased 30.48 11.21 247 150570 110149 42360369
Diabetic ketoacidosis 30.30 11.21 21 150796 22346 42448172
Eczema 30.29 11.21 46 150771 34040 42436478
Chronic lymphocytic leukaemia stage 1 30.05 11.21 7 150810 3 42470515
Colitis 30 11.21 76 150741 46496 42424022
Haematoma 29.87 11.21 33 150784 27990 42442528
Disturbance in attention 29.87 11.21 37 150780 29829 42440689
Clostridium difficile infection 29.74 11.21 22 150795 22637 42447881
Pathogen resistance 29.71 11.21 3 150814 11447 42459071
Staphylococcal infection 29.57 11.21 55 150762 37588 42432930
Insomnia 29.35 11.21 272 150545 117981 42352537
Lymphocyte percentage decreased 29.24 11.21 38 150779 2221 42468297
Abdominal discomfort 29.11 11.21 152 150665 75103 42395415
Unevaluable event 28.84 11.21 48 150769 34240 42436278
Hospitalisation 28.82 11.21 150 150667 74180 42396338
Spinal cord neoplasm 28.72 11.21 16 150801 279 42470239
Cytopenia 28.63 11.21 13 150804 17484 42453034
Cholestasis 28.62 11.21 45 150772 32834 42437684
Generalised tonic-clonic seizure 28.19 11.21 31 150786 26348 42444170
Dysarthria 28.00 11.21 62 150755 39745 42430773
Myasthenia gravis 27.99 11.21 11 150806 16126 42454392
Inflammation 27.90 11.21 48 150769 33799 42436719
Laryngeal cancer stage II 27.89 11.21 6 150811 0 42470518
Epiglottic cancer 27.89 11.21 6 150811 0 42470518
Bladder mass 27.69 11.21 16 150801 300 42470218
Abdominal distension 27.68 11.21 145 150672 71590 42398928
Diabetes mellitus 27.60 11.21 114 150703 59973 42410545
Pneumocystis jirovecii pneumonia 27.56 11.21 29 150788 25152 42445366
Sarcoma 27.47 11.21 18 150799 426 42470092
Mitral valve incompetence 27.38 11.21 12 150805 16477 42454041
Adverse event 27.28 11.21 26 150791 23614 42446904
Miosis 27.17 11.21 7 150810 13439 42457079
Wrong technique in product usage process 27.14 11.21 70 150747 42565 42427953
Chills 27.11 11.21 208 150609 93858 42376660
Intentional self-injury 26.97 11.21 10 150807 15192 42455326
Illness 26.97 11.21 29 150788 24901 42445617
Feeling abnormal 26.96 11.21 141 150676 69645 42400873
Nasal sinus cancer 26.95 11.21 8 150809 21 42470497
Crystal urine present 26.89 11.21 18 150799 442 42470076
Bile duct cancer stage IV 26.78 11.21 7 150810 9 42470509
Adrenal insufficiency 26.67 11.21 17 150800 18907 42451611
Disseminated intravascular coagulation 26.64 11.21 29 150788 24765 42445753
Bronchopulmonary aspergillosis 26.64 11.21 18 150799 19411 42451107
Agranulocytosis 26.54 11.21 42 150775 30570 42439948
Gastrointestinal haemorrhage 26.36 11.21 220 150597 97506 42373012
Blood uric acid increased 26.31 11.21 11 150806 15536 42454982
Cardiac disorder 26.30 11.21 87 150730 48845 42421673
Product use issue 25.92 11.21 162 150655 76589 42393929
Serotonin syndrome 25.86 11.21 32 150785 25813 42444705
Haematotoxicity 25.78 11.21 4 150813 10981 42459537
Lymphopenia 25.73 11.21 23 150794 21540 42448978
Osteoarthritis 25.72 11.21 29 150788 24376 42446142
Pulmonary fibrosis 25.70 11.21 34 150783 26647 42443871
Poisoning 25.53 11.21 10 150807 14689 42455829
Tongue neoplasm 25.25 11.21 8 150809 28 42470490
Lung disorder 25.21 11.21 86 150731 47837 42422681
Hepatocellular injury 25.11 11.21 28 150789 23650 42446868
Acute myeloid leukaemia 25.08 11.21 25 150792 22231 42448287
Oroantral fistula 24.95 11.21 13 150804 197 42470321
Blood bilirubin increased 24.92 11.21 72 150745 42180 42428338
Haemophagocytic lymphohistiocytosis 24.82 11.21 17 150800 18205 42452313
Parkinsonism 24.63 11.21 4 150813 10619 42459899
Pericardial effusion 24.60 11.21 41 150776 29234 42441284
Acute hepatic failure 24.52 11.21 15 150802 17058 42453460
Oesophageal polyp 24.51 11.21 9 150808 54 42470464
Bile duct cancer 24.43 11.21 20 150797 673 42469845
Toxic skin eruption 24.42 11.21 9 150808 13721 42456797
Musculoskeletal pain 24.22 11.21 51 150766 33289 42437229
Cognitive disorder 24.22 11.21 53 150764 34119 42436399
Blood pressure fluctuation 24.21 11.21 36 150781 26872 42443646
Adverse drug reaction 24.18 11.21 61 150756 37373 42433145
Aggression 24.09 11.21 78 150739 44085 42426433
Heart rate decreased 24.01 11.21 59 150758 36473 42434045
Myelodysplastic syndrome 24.00 11.21 27 150790 22718 42447800
Iron deficiency 23.86 11.21 5 150812 11056 42459462
Specific gravity urine increased 23.81 11.21 12 150805 169 42470349
Neutrophil percentage increased 23.80 11.21 32 150785 1933 42468585
Nasopharyngeal cancer stage IV 23.75 11.21 6 150811 6 42470512
Drug eruption 23.69 11.21 28 150789 23047 42447471
Injection site erythema 23.55 11.21 22 150795 20173 42450345
Skin ulcer 23.28 11.21 34 150783 25567 42444951
Head and neck cancer stage III 23.24 11.21 5 150812 0 42470518
Anal cancer stage III 23.24 11.21 5 150812 0 42470518
Bile duct cancer stage III 23.24 11.21 5 150812 0 42470518
Malignant melanoma stage III 23.24 11.21 5 150812 0 42470518
Pneumopericardium 23.23 11.21 11 150806 134 42470384
Productive cough 22.96 11.21 99 150718 51468 42419050
Skin exfoliation 22.94 11.21 73 150744 41480 42429038
Tachycardia 22.78 11.21 238 150579 100849 42369669
Metastatic carcinoma of the bladder 22.73 11.21 13 150804 239 42470279
Clostridium difficile colitis 22.68 11.21 25 150792 21227 42449291
Depressed level of consciousness 22.66 11.21 90 150727 47880 42422638
Glomerular filtration rate decreased 22.62 11.21 15 150802 16336 42454182
Dyspnoea exertional 22.50 11.21 96 150721 50052 42420466
Ejection fraction decreased 22.47 11.21 27 150790 22060 42448458
Discomfort 22.44 11.21 34 150783 25185 42445333
Fungal infection 22.40 11.21 22 150795 19700 42450818
Cardiogenic shock 22.31 11.21 59 150758 35581 42434937
Loss of consciousness 22.24 11.21 214 150603 92140 42378378
Graft versus host disease 22.11 11.21 9 150808 12916 42457602
Bone marrow failure 22.10 11.21 53 150764 33040 42437478
Hypophosphataemia 21.95 11.21 25 150792 20920 42449598
Neutrophil count decreased 21.86 11.21 133 150684 63282 42407236
Dysphagia 21.81 11.21 159 150658 72560 42397958
Hallucination 21.76 11.21 117 150700 57390 42413128
Congenital multiplex arthrogryposis 21.76 11.21 13 150804 260 42470258
Localised infection 21.70 11.21 24 150793 20349 42450169
Arteriosclerosis 21.69 11.21 19 150798 17970 42452548
Acute respiratory failure 21.64 11.21 68 150749 38790 42431728
Treatment noncompliance 21.63 11.21 65 150752 37607 42432911
Tooth deposit 21.49 11.21 9 150808 80 42470438
Electrocardiogram QT prolonged 21.37 11.21 92 150725 47853 42422665
Pneumonia aspiration 21.18 11.21 98 150719 49980 42420538
Ventricular fibrillation 21.12 11.21 47 150770 30076 42440442
Cutaneous lupus erythematosus 20.98 11.21 20 150797 826 42469692
Gamma-glutamyltransferase increased 20.95 11.21 53 150764 32444 42438074
Hypothyroidism 20.94 11.21 52 150765 32032 42438486
Aphasia 20.92 11.21 33 150784 24050 42446468
Dyslipidaemia 20.85 11.21 4 150813 9414 42461104
Hypogammaglobulinaemia 20.80 11.21 8 150809 11883 42458635
Epilepsy 20.77 11.21 38 150779 26133 42444385
Drug level fluctuating 20.77 11.21 18 150799 656 42469862
Monocyte percentage increased 20.76 11.21 22 150795 1033 42469485
Hyperphosphataemia 20.76 11.21 10 150807 12994 42457524
Infusion related reaction 20.71 11.21 128 150689 60678 42409840
Medication error 20.67 11.21 55 150762 33099 42437419
Eosinophilic granulomatosis with polyangiitis 20.61 11.21 3 150814 8635 42461883
Swelling 20.58 11.21 112 150705 54773 42415745
Depressed mood 20.35 11.21 32 150785 23352 42447166
Head and neck cancer 20.33 11.21 15 150802 432 42470086
Prostate cancer recurrent 20.28 11.21 22 150795 1061 42469457
Tricuspid valve incompetence 20.25 11.21 7 150810 11106 42459412
Drug withdrawal syndrome 20.21 11.21 28 150789 21521 42448997
Akathisia 20.07 11.21 6 150811 10445 42460073
Malignant melanoma 20.07 11.21 76 150741 9324 42461194
Drug level increased 19.95 11.21 39 150778 26161 42444357
Liver injury 19.91 11.21 23 150794 19125 42451393
Thrombotic microangiopathy 19.86 11.21 14 150803 14768 42455750
Haemolytic anaemia 19.86 11.21 9 150808 12118 42458400
Stomatitis 19.83 11.21 101 150716 50228 42420290
Anal cancer 19.80 11.21 15 150802 450 42470068
Tumour lysis syndrome 19.75 11.21 30 150787 22201 42448317
Breast cancer 19.68 11.21 13 150804 312 42470206
Lymphoproliferative disorder 19.65 11.21 39 150778 3268 42467250
Venoocclusive liver disease 19.63 11.21 6 150811 10296 42460222
Cerebral palsy 19.53 11.21 14 150803 385 42470133
Intentional dose omission 19.51 11.21 4 150813 8982 42461536
Carcinoid tumour 19.36 11.21 12 150805 257 42470261
Renal cancer recurrent 19.35 11.21 7 150810 40 42470478
Therapeutic response shortened 19.34 11.21 12 150805 13542 42456976
Cellulitis 19.27 11.21 133 150684 61452 42409066
Blood alkaline phosphatase increased 19.27 11.21 58 150759 33539 42436979
Contusion 19.06 11.21 80 150737 41905 42428613
Pericarditis 19.05 11.21 12 150805 13432 42457086
Subdural haematoma 18.90 11.21 33 150784 23105 42447413
Device malfunction 18.89 11.21 10 150807 12317 42458201
Lymphadenopathy 18.85 11.21 58 150759 33307 42437211
Affective disorder 18.81 11.21 55 150762 5905 42464613
Mobility decreased 18.81 11.21 63 150754 35243 42435275
Acute respiratory distress syndrome 18.73 11.21 50 150767 30058 42440460
Neurological symptom 18.72 11.21 6 150811 9985 42460533
Gingival atrophy 18.66 11.21 7 150810 45 42470473
Malignant splenic neoplasm 18.59 11.21 4 150813 0 42470518
Ovarian cancer 18.59 11.21 4 150813 0 42470518
Colon cancer stage 0 18.59 11.21 4 150813 0 42470518
Small intestine carcinoma stage 0 18.59 11.21 4 150813 0 42470518
Anal cancer stage II 18.59 11.21 4 150813 0 42470518
Gallbladder cancer stage 0 18.59 11.21 4 150813 0 42470518
Gallbladder cancer stage II 18.59 11.21 4 150813 0 42470518
Nasopharyngeal cancer stage III 18.59 11.21 4 150813 0 42470518
Bile duct cancer stage II 18.59 11.21 4 150813 0 42470518
Laboratory test abnormal 18.56 11.21 33 150784 22945 42447573
Prostatomegaly 18.55 11.21 56 150761 6121 42464397
Tendonitis 18.43 11.21 6 150811 9888 42460630
Blood pressure increased 18.36 11.21 252 150565 101676 42368842
Bronchiectasis 18.36 11.21 22 150795 17997 42452521
Hypopnoea 18.20 11.21 3 150814 7879 42462639
Agitation 18.16 11.21 143 150674 64171 42406347
Hyperthermia 18.13 11.21 11 150806 12563 42457955
Benign neoplasm of bladder 18.12 11.21 5 150812 9 42470509
Product administration error 18.05 11.21 23 150794 18320 42452198
Gingival pain 17.99 11.21 4 150813 8490 42462028
Pallor 17.94 11.21 48 150769 28838 42441680
Coronary artery disease 17.82 11.21 114 150703 53606 42416912
Oesophageal pain 17.76 11.21 20 150797 1006 42469512
Rectal haemorrhage 17.64 11.21 103 150714 49503 42421015
Joint stiffness 17.46 11.21 11 150806 12311 42458207
Unresponsive to stimuli 17.45 11.21 55 150762 31348 42439170
Bronchitis 17.33 11.21 97 150720 47104 42423414
Sinus tachycardia 17.28 11.21 29 150788 20624 42449894
Alcohol poisoning 17.23 11.21 3 150814 7571 42462947
Renal cell carcinoma stage III 17.16 11.21 5 150812 12 42470506
Hepatic steatosis 17.15 11.21 31 150786 21417 42449101
Respiratory arrest 17.08 11.21 48 150769 28376 42442142
Inappropriate antidiuretic hormone secretion 17.06 11.21 20 150797 16521 42453997
Urinary retention 17.04 11.21 84 150733 42130 42428388
Dry mouth 16.88 11.21 78 150739 39801 42430717
Prostatic dysplasia 16.88 11.21 5 150812 13 42470505
Nasopharyngitis 16.85 11.21 203 150614 83793 42386725
Pneumonitis 16.84 11.21 83 150734 41635 42428883
Red blood cell sedimentation rate increased 16.83 11.21 7 150810 9917 42460601
Nephrolithiasis 16.83 11.21 70 150747 36760 42433758
Proteinuria 16.82 11.21 35 150782 22948 42447570
Dry eye 16.81 11.21 18 150799 15488 42455030
Progressive multifocal leukoencephalopathy 16.76 11.21 10 150807 11526 42458992
White blood cells urine positive 16.75 11.21 23 150794 1418 42469100
Blood phosphorus increased 16.65 11.21 12 150805 12513 42458005
Colitis ulcerative 16.64 11.21 43 150774 26132 42444386
Subarachnoid haemorrhage 16.60 11.21 16 150801 14456 42456062
Diabetes mellitus inadequate control 16.54 11.21 18 150799 15372 42455146
Gastrointestinal disorder 16.52 11.21 97 150720 46556 42423962
Nasal neoplasm 16.44 11.21 8 150809 104 42470414
Restlessness 16.41 11.21 51 150766 29198 42441320
Rectal cancer stage IV 16.36 11.21 4 150813 3 42470515
Ocular surface squamous neoplasia 16.34 11.21 6 150811 36 42470482
Pulmonary hypertension 16.34 11.21 37 150780 23532 42446986
Influenza 16.30 11.21 141 150676 62034 42408484
Underdose 16.29 11.21 21 150796 16645 42453873
Hyperthyroidism 16.28 11.21 16 150801 14325 42456193
Prescribed underdose 16.27 11.21 8 150809 10274 42460244
Visual acuity reduced 16.26 11.21 23 150794 17527 42452991
Injection site reaction 16.22 11.21 19 150798 15702 42454816
Sudden death 16.21 11.21 21 150796 16608 42453910
Eye irritation 16.18 11.21 10 150807 11308 42459210
Rash maculo-papular 16.09 11.21 73 150744 37430 42433088
Injection site swelling 15.97 11.21 22 150795 16951 42453567
Injection site haemorrhage 15.92 11.21 11 150806 11725 42458793
Immune reconstitution inflammatory syndrome 15.89 11.21 8 150809 10135 42460383
Second primary malignancy 15.85 11.21 7 150810 9568 42460950
Road traffic accident 15.80 11.21 27 150790 19066 42451452
Parosmia 15.55 11.21 4 150813 7687 42462831
Splenic neoplasm malignancy unspecified 15.46 11.21 5 150812 19 42470499
Bacterial infection 15.37 11.21 49 150768 27830 42442688
Bladder transitional cell carcinoma 15.24 11.21 31 150786 2645 42467873
BK virus infection 15.22 11.21 6 150811 8778 42461740
Cardiomyopathy 15.15 11.21 28 150789 19182 42451336
Systemic lupus erythematosus 15.14 11.21 7 150810 9317 42461201
Dermatitis atopic 15.08 11.21 13 150804 12391 42458127
Aspiration 15.07 11.21 25 150792 17861 42452657
Cytomegalovirus viraemia 15.07 11.21 9 150808 10368 42460150
Liver function test increased 15.03 11.21 30 150787 19968 42450550
Delusion 15.00 11.21 18 150799 14716 42455802
Uveitis 14.96 11.21 7 150810 9251 42461267
Bundle branch block right 14.95 11.21 5 150812 8101 42462417
Chronic leukaemia 14.95 11.21 4 150813 6 42470512
Arteriosclerosis coronary artery 14.93 11.21 27 150790 18650 42451868
Disorientation 14.92 11.21 72 150745 36317 42434201
Lip neoplasm malignant stage unspecified 14.88 11.21 5 150812 22 42470496
Klebsiella infection 14.87 11.21 11 150806 11321 42459197
Diverticulitis 14.79 11.21 37 150780 22736 42447782
Acute graft versus host disease in skin 14.74 11.21 4 150813 7420 42463098
Orthostatic hypotension 14.66 11.21 57 150760 30513 42440005
Paraneoplastic rash 14.66 11.21 7 150810 87 42470431
Hyperbilirubinaemia 14.62 11.21 32 150785 20603 42449915
Eosinophil percentage increased 14.59 11.21 14 150803 583 42469935
Dysstasia 14.56 11.21 17 150800 14069 42456449
Palmar-plantar erythrodysaesthesia syndrome 14.52 11.21 32 150785 20550 42449968
Haemorrhage intracranial 14.52 11.21 24 150793 17168 42453350
Surgery 14.50 11.21 25 150792 17591 42452927
Ill-defined disorder 14.47 11.21 22 150795 16274 42454244
Atrial septal defect 14.41 11.21 5 150812 7914 42462604
Product storage error 14.38 11.21 11 150806 11129 42459389
Normochromic normocytic anaemia 14.33 11.21 7 150810 9024 42461494
Amnesia 14.31 11.21 52 150765 28385 42442133
Hemiplegia 14.29 11.21 5 150812 7874 42462644
Right ventricular failure 14.28 11.21 8 150809 9547 42460971
Paraesthesia 14.18 11.21 179 150638 73280 42397238
Angina pectoris 14.13 11.21 64 150753 32832 42437686
Infective pulmonary exacerbation of cystic fibrosis 14.12 11.21 60 150757 7758 42462760
Withdrawal syndrome 14.05 11.21 19 150798 14756 42455762
Urine abnormality 14.03 11.21 27 150790 2212 42468306
Osteomyelitis 13.98 11.21 27 150790 18196 42452322
Oropharyngeal cancer stage IV 13.94 11.21 3 150814 0 42470518
Head and neck cancer stage I 13.94 11.21 3 150814 0 42470518
Follicular lymphoma stage III 13.94 11.21 3 150814 0 42470518
B-cell lymphoma stage III 13.94 11.21 3 150814 0 42470518
Bile duct cancer stage I 13.94 11.21 3 150814 0 42470518
Salivary gland cancer stage I 13.94 11.21 3 150814 0 42470518
Dementia 13.92 11.21 23 150794 16457 42454061
Mucormycosis 13.90 11.21 4 150813 7139 42463379
Sinusitis 13.89 11.21 104 150713 47188 42423330
Hyperglycaemia 13.88 11.21 100 150717 45759 42424759
Staphylococcal sepsis 13.83 11.21 12 150805 11402 42459116
Bacteraemia 13.81 11.21 44 150773 24996 42445522
Band neutrophil percentage increased 13.80 11.21 7 150810 100 42470418
Urine leukocyte esterase positive 13.74 11.21 12 150805 442 42470076
Frequent bowel movements 13.73 11.21 35 150782 21372 42449146
Dystonia 13.70 11.21 15 150802 12775 42457743
Dyspepsia 13.69 11.21 214 150603 41138 42429380
Mental impairment 13.69 11.21 14 150803 12303 42458215
Device leakage 13.48 11.21 10 150807 10275 42460243
Maternal exposure during pregnancy 13.41 11.21 4 150813 6974 42463544
Splenomegaly 13.31 11.21 25 150792 17022 42453496
Bacterial test 13.30 11.21 8 150809 162 42470356
Foetal hypokinesia 13.21 11.21 11 150806 379 42470139
Pneumonia fungal 13.19 11.21 8 150809 9138 42461380
Pneumonia bacterial 13.16 11.21 22 150795 15670 42454848
Troponin increased 13.15 11.21 30 150787 19032 42451486
Haemodynamic instability 13.15 11.21 15 150802 12542 42457976
Irritability 13.14 11.21 53 150764 28075 42442443
Nodule 13.09 11.21 15 150802 12519 42457999
Gastric cancer recurrent 13.09 11.21 5 150812 34 42470484
Malignant neoplasm of ampulla of Vater 13.09 11.21 4 150813 12 42470506
Muscle rigidity 13.07 11.21 14 150803 12045 42458473
Optic discs blurred 13.05 11.21 6 150811 68 42470450
Haematuria 13.05 11.21 136 150681 57663 42412855
Cardiac failure chronic 13.02 11.21 9 150808 9592 42460926
Melaena 12.96 11.21 82 150735 38664 42431854
Renal cell carcinoma 12.95 11.21 46 150771 5471 42465047
Prescribed overdose 12.94 11.21 16 150801 12911 42457607
Glycosylated haemoglobin increased 12.93 11.21 16 150801 12908 42457610
Hepatic encephalopathy 12.93 11.21 24 150793 16418 42454100
Bilirubin urine present 12.88 11.21 8 150809 172 42470346
Skin lesion 12.82 11.21 51 150766 27123 42443395
Upper respiratory tract infection 12.74 11.21 92 150725 42081 42428437
Cystitis haemorrhagic 12.71 11.21 5 150812 7324 42463194
Psychomotor hyperactivity 12.70 11.21 12 150805 10946 42459572
Therapy cessation 12.69 11.21 34 150783 20416 42450102
Oropharyngeal cancer 12.68 11.21 6 150811 73 42470445
Central nervous system lesion 12.64 11.21 6 150811 7864 42462654
Hyperammonaemia 12.63 11.21 6 150811 7860 42462658
Kounis syndrome 12.53 11.21 33 150784 3335 42467183
Delirium 12.51 11.21 122 150695 52397 42418121
Myoclonus 12.48 11.21 26 150791 17039 42453479
Product quality issue 12.45 11.21 28 150789 17854 42452664
Generalised oedema 12.41 11.21 22 150795 15314 42455204
Asphyxia 12.40 11.21 7 150810 8319 42462199
Conductive deafness 12.40 11.21 12 150805 505 42470013
Oxygen saturation decreased 12.35 11.21 158 150659 64529 42405989
Rib fracture 12.33 11.21 25 150792 16546 42453972
Peritonitis 12.31 11.21 30 150787 18603 42451915
Brain neoplasm 12.31 11.21 34 150783 3534 42466984
Oliguria 12.28 11.21 9 150808 9304 42461214
Immunosuppressant drug level increased 12.26 11.21 6 150811 7725 42462793
Hyperaesthesia 12.22 11.21 3 150814 5949 42464569
Hypocalcaemia 12.20 11.21 60 150757 30113 42440405
Full blood count decreased 12.15 11.21 35 150782 20525 42449993
Hypertensive crisis 12.04 11.21 11 150806 10195 42460323
Labelled drug-drug interaction medication error 12.03 11.21 23 150794 15559 42454959
Transient ischaemic attack 12.02 11.21 70 150747 33669 42436849
Eye disorder 12.02 11.21 14 150803 11598 42458920
Urine analysis abnormal 12 11.21 25 150792 2169 42468349
Tachypnoea 11.99 11.21 38 150779 21624 42448894
Pulmonary arterial hypertension 11.99 11.21 11 150806 10176 42460342
Skin fissures 11.93 11.21 10 150807 9666 42460852
Abscess 11.93 11.21 20 150797 14228 42456290
Ankylosing spondylitis 11.93 11.21 5 150812 7051 42463467
Behaviour disorder 11.92 11.21 5 150812 7049 42463469
Respiratory symptom 11.92 11.21 13 150804 11093 42459425
Chronic kidney disease 11.88 11.21 234 150583 47007 42423511
Iris adhesions 11.88 11.21 9 150808 270 42470248
Malignant neoplasm of thorax 11.87 11.21 3 150814 3 42470515
Prostatic atrophy 11.87 11.21 3 150814 3 42470515
Rash pruritic 11.83 11.21 70 150747 33533 42436985
Hypervolaemia 11.82 11.21 42 150775 23083 42447435
Intraocular pressure increased 11.81 11.21 4 150813 6429 42464089
Gout 11.80 11.21 55 150762 28000 42442518
Atrioventricular block 11.78 11.21 10 150807 9605 42460913
Hypercholesterolaemia 11.75 11.21 17 150800 12832 42457686
Bone marrow tumour cell infiltration 11.66 11.21 4 150813 19 42470499
Bone pain 11.64 11.21 44 150773 23748 42446770
Malnutrition 11.64 11.21 21 150796 14521 42455997
Liposarcoma 11.63 11.21 7 150810 142 42470376
Abdominal pain upper 11.60 11.21 214 150603 82395 42388123
Cardiac murmur 11.58 11.21 17 150800 12758 42457760
Anorectal discomfort 11.53 11.21 25 150792 2230 42468288
Escherichia infection 11.52 11.21 14 150803 11382 42459136
SARS-CoV-2 test false positive 11.49 11.21 4 150813 20 42470498
Therapeutic response unexpected 11.48 11.21 14 150803 11367 42459151
Ataxia 11.43 11.21 25 150792 16100 42454418
Lymphocele 11.39 11.21 20 150797 1527 42468991
Metastatic gastric cancer 11.33 11.21 7 150810 149 42470369
Injection site pruritus 11.26 11.21 10 150807 9395 42461123
Hypercalcaemia 11.22 11.21 30 150787 18028 42452490
Candida infection 11.21 11.21 39 150778 21571 42448947

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Prostate cancer 44224.15 10.00 12506 391631 25135 110160027
Bladder cancer 35571.69 10.00 9250 394887 11042 110174120
Oesophageal carcinoma 28885.22 10.00 6998 397139 4526 110180636
Colorectal cancer 27706.50 10.00 6470 397667 2644 110182518
Breast cancer stage I 26321.22 10.00 5968 398169 1419 110183743
Breast cancer female 25279.04 10.00 6387 397750 6081 110179081
Renal cancer 24712.76 10.00 6329 397808 6705 110178457
Colorectal cancer stage III 15122.59 10.00 3276 400861 11 110185151
Breast cancer stage II 14790.12 10.00 5026 399111 22349 110162813
Colorectal cancer stage IV 13906.68 10.00 3016 401121 25 110185137
Gastric cancer 12239.68 10.00 3512 400625 7496 110177666
Prostate cancer stage I 11489.02 10.00 2511 401626 111 110185051
Hepatic cancer stage IV 11447.35 10.00 2485 401652 30 110185132
Hepatic cancer 10400.95 10.00 3105 401032 8051 110177111
Prostate cancer stage IV 10287.17 10.00 2272 401865 216 110184946
Prostate cancer stage II 9308.81 10.00 2050 402087 165 110184997
Pancreatic carcinoma stage IV 9276.52 10.00 2045 402092 175 110184987
Colorectal cancer stage II 8556.71 10.00 1853 402284 0 110185162
Prostate cancer stage III 8066.06 10.00 1753 402384 29 110185133
Pancreatic carcinoma 7437.54 10.00 2579 401558 12293 110172869
Renal cancer stage IV 7410.28 10.00 1619 402518 67 110185095
Breast cancer stage IV 7408.85 10.00 1670 402467 333 110184829
Renal cancer stage I 7106.49 10.00 1544 402593 23 110185139
Gastric cancer stage IV 6661.84 10.00 1453 402684 48 110185114
Colorectal cancer stage I 6117.67 10.00 1325 402812 0 110185162
Lung carcinoma cell type unspecified stage IV 6011.53 10.00 1437 402700 785 110184377
Gastrointestinal carcinoma 5227.92 10.00 1406 402731 2067 110183095
Bladder cancer stage IV 5108.51 10.00 1108 403029 7 110185155
Bladder cancer stage II 5107.52 10.00 1108 403029 8 110185154
Renal cancer stage II 5012.87 10.00 1089 403048 15 110185147
Renal cancer stage III 4952.84 10.00 1076 403061 15 110185147
Breast cancer stage III 4860.23 10.00 3228 400909 75889 110109273
Lung neoplasm malignant 3930.51 10.00 2084 402053 31758 110153404
Uterine cancer 3868.27 10.00 1157 402980 3017 110182145
Bladder cancer stage III 3794.75 10.00 822 403315 0 110185162
Gastric cancer stage I 3753.20 10.00 813 403324 0 110185162
Testis cancer 3313.79 10.00 802 403335 503 110184659
Thyroid cancer 3243.06 10.00 1113 403024 5101 110180061
Skin cancer 2697.58 10.00 1312 402825 16472 110168690
Gastric cancer stage III 2595.33 10.00 565 403572 13 110185149
Gastric cancer stage II 2534.27 10.00 549 403588 0 110185162
Haematological malignancy 2409.66 10.00 590 403547 417 110184745
Pancreatic carcinoma stage III 2194.27 10.00 476 403661 3 110185159
Brain neoplasm malignant 2174.39 10.00 619 403518 1261 110183901
Pancreatic carcinoma stage II 2151.08 10.00 466 403671 0 110185162
Lung carcinoma cell type unspecified stage I 2080.89 10.00 470 403667 98 110185064
Neoplasm malignant 2070.35 10.00 1428 402709 35715 110149447
Prostate cancer stage 0 1809.46 10.00 392 403745 0 110185162
Lung carcinoma cell type unspecified stage III 1715.90 10.00 394 403743 118 110185044
Throat cancer 1603.69 10.00 486 403651 1345 110183817
Pancreatic carcinoma stage I 1566.43 10.00 340 403797 3 110185159
Hepatic cancer stage III 1518.63 10.00 329 403808 0 110185162
Hepatic cancer stage I 1329.36 10.00 288 403849 0 110185162
Hepatic cancer stage II 1310.90 10.00 284 403853 0 110185162
Thyroid cancer stage I 1209.34 10.00 262 403875 0 110185162
Lung carcinoma cell type unspecified stage II 1200.21 10.00 269 403868 45 110185117
Disease progression 1134.97 10.00 2653 401484 241381 109943781
Breast cancer 1088.13 10.00 993 403144 37549 110147613
Bone cancer 1061.64 10.00 383 403754 2087 110183075
Drug ineffective 1033.34 10.00 2548 401589 1517992 108667170
Ovarian cancer 921.52 10.00 406 403731 3990 110181172
Appendix cancer 839.25 10.00 202 403935 119 110185043
Off label use 795.11 10.00 2822 401315 1497363 108687799
Small intestine carcinoma 741.72 10.00 240 403897 878 110184284
Toxicity to various agents 733.20 10.00 423 403714 480132 109705030
Thyroid cancer stage II 641.58 10.00 139 403998 0 110185162
Thyroid cancer stage IV 634.00 10.00 138 403999 3 110185159
Ovarian cancer stage IV 604.10 10.00 146 403991 90 110185072
Death 600.68 10.00 1020 403117 697849 109487313
Small intestine carcinoma stage IV 576.95 10.00 125 404012 0 110185162
Ovarian cancer stage I 530.80 10.00 115 404022 0 110185162
Bladder cancer stage I, with cancer in situ 521.57 10.00 113 404024 0 110185162
Breast cancer male 513.59 10.00 139 403998 212 110184950
Completed suicide 486.33 10.00 141 403996 242240 109942922
Thyroid cancer stage III 466.18 10.00 101 404036 0 110185162
Cervix carcinoma 457.43 10.00 210 403927 2291 110182871
Gallbladder cancer 419.65 10.00 133 404004 447 110184715
Condition aggravated 415.43 10.00 1341 402796 733495 109451667
Acute kidney injury 410.39 10.00 1089 403048 634341 109550821
Colon cancer stage IV 400.79 10.00 123 404014 360 110184802
Prostatic disorder 395.14 10.00 190 403947 2319 110182843
Gastric cancer stage 0 384.88 10.00 86 404051 13 110185149
Colorectal carcinoma stage 0 364.63 10.00 79 404058 0 110185162
Colon cancer 355.50 10.00 366 403771 16077 110169085
Drug interaction 352.62 10.00 819 403318 499364 109685798
Ovarian cancer stage III 335.73 10.00 96 404041 200 110184962
Lymphoma 335.23 10.00 391 403746 19780 110165382
Anaemia 332.68 10.00 965 403172 546121 109639041
Thyroid cancer stage 0 332.32 10.00 72 404065 0 110185162
Drug abuse 329.64 10.00 118 404019 177293 110007869
Gallbladder cancer stage IV 313.86 10.00 68 404069 0 110185162
Colon cancer stage III 311.23 10.00 93 404044 241 110184921
Ovarian cancer stage II 306.32 10.00 67 404070 3 110185159
Fall 293.14 10.00 1173 402964 602309 109582853
Food allergy 287.94 10.00 360 403777 19588 110165574
Temperature regulation disorder 283.64 10.00 289 403848 12537 110172625
Nasal cavity cancer 275.08 10.00 83 404054 225 110184937
Rheumatoid factor positive 266.88 10.00 75 404062 131565 110053597
Pneumonia 264.20 10.00 1998 402139 874716 109310446
Cervix carcinoma stage I 257.40 10.00 57 404080 6 110185156
Infection 252.74 10.00 596 403541 361604 109823558
Pyrexia 245.83 10.00 2101 402036 896164 109288998
Sleep disorder due to general medical condition, insomnia type 242.35 10.00 46 404091 105597 110079565
Small intestine carcinoma stage III 240.01 10.00 52 404085 0 110185162
Colon cancer stage I 236.57 10.00 60 404077 58 110185104
Colon cancer stage II 228.56 10.00 70 404067 203 110184959
Myelosuppression 225.29 10.00 37 404100 94303 110090859
Sinusitis 225.19 10.00 466 403671 296222 109888940
Multiple organ dysfunction syndrome 224.71 10.00 138 403999 151572 110033590
COVID-19 224.71 10.00 342 403795 244718 109940444
Pancytopenia 224.31 10.00 261 403876 209352 109975810
Diarrhoea 216.57 10.00 2901 401236 1136604 109048558
Sepsis 212.47 10.00 559 403578 326787 109858375
Intentional overdose 211.36 10.00 110 404027 132391 110052771
Arthralgia 204.09 10.00 1844 402293 777788 109407374
Loss of personal independence in daily activities 204.02 10.00 150 403987 149870 110035292
Anhedonia 203.10 10.00 266 403871 15162 110170000
Lung carcinoma cell type unspecified stage 0 201.74 10.00 51 404086 48 110185114
Injection site pain 200.85 10.00 212 403925 177710 110007452
Product use in unapproved indication 195.93 10.00 904 403233 446473 109738689
Small intestine carcinoma stage II 193.85 10.00 42 404095 0 110185162
Coeliac disease 191.10 10.00 461 403676 42726 110142436
Cervix carcinoma stage IV 190.48 10.00 48 404089 44 110185118
Malignant neoplasm progression 190.42 10.00 214 403923 174353 110010809
Crystal urine present 188.79 10.00 107 404030 1867 110183295
Cervix carcinoma stage II 187.27 10.00 45 404092 26 110185136
Febrile neutropenia 186.34 10.00 567 403570 316200 109868962
Tongue carcinoma stage IV 184.62 10.00 40 404097 0 110185162
Therapy non-responder 183.73 10.00 182 403955 157125 110028037
Neutropenia 183.66 10.00 725 403412 373895 109811267
Oedema 183.06 10.00 303 403834 209673 109975489
Renal impairment 177.58 10.00 258 403879 188187 109996975
Suicide attempt 176.89 10.00 78 404059 103316 110081846
Leukaemia 174.67 10.00 174 403963 7344 110177818
Urinary sediment present 174.22 10.00 111 404026 2417 110182745
Product dose omission issue 173.28 10.00 599 403538 321183 109863979
Septic shock 171.93 10.00 193 403944 157335 110027827
Fatigue 171.26 10.00 3274 400863 1212684 108972478
Pancreatic carcinoma stage 0 170.77 10.00 37 404100 0 110185162
Small intestine carcinoma stage I 170.77 10.00 37 404100 0 110185162
Blepharospasm 168.71 10.00 512 403625 54339 110130823
Urine abnormality 165.84 10.00 185 403952 8911 110176251
Adrenal gland cancer 164.98 10.00 47 404090 96 110185066
Hepatic cytolysis 164.27 10.00 9 404128 55044 110130118
Lactic acidosis 163.60 10.00 67 404070 92744 110092418
Hypotension 163.09 10.00 1182 402955 522667 109662495
Drug resistance 157.14 10.00 13 404124 56361 110128801
Tongue neoplasm malignant stage unspecified 156.87 10.00 83 404054 1256 110183906
Cardiac failure 154.20 10.00 281 403856 187345 109997817
Drug ineffective for unapproved indication 153.04 10.00 93 404044 102745 110082417
General physical health deterioration 152.30 10.00 920 403217 424375 109760787
Respiratory failure 151.97 10.00 352 403785 214980 109970182
Cervix carcinoma stage III 148.46 10.00 36 404101 23 110185139
Urine leukocyte esterase positive 146.64 10.00 117 404020 3669 110181493
Gastrooesophageal reflux disease 146.13 10.00 1142 402995 178834 110006328
Dyspnoea 144.67 10.00 3017 401120 1103855 109081307
Arthritis 143.13 10.00 245 403892 167341 110017821
Oesophageal carcinoma stage 0 143.08 10.00 31 404106 0 110185162
Weight decreased 142.83 10.00 1062 403075 466995 109718167
Cytokine release syndrome 142.59 10.00 40 404097 70266 110114896
Arthropathy 141.15 10.00 556 403581 286966 109898196
Lymphocyte percentage decreased 140.50 10.00 132 404005 5178 110179984
Decreased appetite 137.99 10.00 1095 403042 474751 109710411
Discomfort 135.96 10.00 371 403766 214336 109970826
Swollen joint count increased 135.58 10.00 68 404069 83593 110101569
Neutrophil percentage increased 135.53 10.00 125 404012 4788 110180374
Immunodeficiency 134.27 10.00 378 403759 38460 110146702
Myocardial infarction 132.34 10.00 318 403819 191765 109993397
Pulmonary embolism 131.06 10.00 377 403760 214097 109971065
Nausea 130.40 10.00 3480 400657 1232210 108952952
Cerebrovascular accident 129.80 10.00 294 403843 180990 110004172
Oedema peripheral 127.83 10.00 692 403445 327968 109857194
Atrial fibrillation 127.32 10.00 422 403715 229220 109955942
Urine analysis abnormal 126.99 10.00 141 403996 6756 110178406
Joint swelling 126.57 10.00 1023 403114 441822 109743340
White blood cells urine positive 125.27 10.00 146 403991 7378 110177784
Incorrect dose administered 123.34 10.00 723 403414 102918 110082244
Red blood cells urine positive 122.31 10.00 121 404016 5064 110180098
Laryngeal cancer stage I 120.00 10.00 26 404111 0 110185162
Alopecia 119.82 10.00 810 403327 363943 109821219
Hyperkalaemia 118.29 10.00 196 403941 135600 110049562
Rhabdomyolysis 118.24 10.00 160 403977 120241 110064921
Hepatic cancer metastatic 118.19 10.00 62 404075 921 110184241
Vomiting 117.72 10.00 2486 401651 908189 109276973
Taste disorder 117.22 10.00 512 403625 64875 110120287
Lymphocyte count decreased 116.51 10.00 466 403671 56777 110128385
Thrombocytopenia 116.48 10.00 771 403366 348114 109837048
Accidental exposure to product 116.35 10.00 21 404116 49987 110135175
Lip and/or oral cavity cancer 115.15 10.00 65 404072 1125 110184037
Therapeutic response decreased 113.41 10.00 111 404026 96388 110088774
Tongue carcinoma stage III 110.77 10.00 24 404113 0 110185162
Synovitis 108.84 10.00 573 403564 273519 109911643
Therapy interrupted 107.46 10.00 25 404112 49797 110135365
Disability 107.28 10.00 297 403840 29926 110155236
Brain cancer metastatic 105.46 10.00 42 404095 312 110184850
Haematochezia 105.09 10.00 162 403975 115362 110069800
Urinary tract infection 104.46 10.00 730 403407 325552 109859610
Depressed level of consciousness 103.53 10.00 156 403981 112122 110073040
Tongue carcinoma stage II 101.54 10.00 22 404115 0 110185162
Weight increased 100.83 10.00 1013 403124 418631 109766531
Metabolic acidosis 100.54 10.00 130 404007 99614 110085548
Knee arthroplasty 100.51 10.00 56 404081 64892 110120270
Encephalopathy 100.25 10.00 89 404048 80966 110104196
Deep vein thrombosis 100.02 10.00 227 403910 139660 110045502
Tonsil cancer 99.20 10.00 61 404076 1245 110183917
Bone cancer metastatic 98.71 10.00 39 404098 283 110184879
Bursitis 98.69 10.00 812 403325 129106 110056056
Onychomadesis 98.01 10.00 378 403759 45285 110139877
Interstitial lung disease 97.29 10.00 229 403908 139105 110046057
Dehydration 97.19 10.00 610 403527 278901 109906261
Pain 97 10.00 2703 401434 952252 109232910
Gallbladder cancer stage I 96.93 10.00 21 404116 0 110185162
Sedation 96.91 10.00 68 404069 69615 110115547
Altered state of consciousness 96.18 10.00 45 404092 57581 110127581
Asthenia 95.13 10.00 1860 402277 687139 109498023
Urethral cancer 94.78 10.00 26 404111 43 110185119
Chronic obstructive pulmonary disease 94.65 10.00 158 403979 109000 110076162
Confusional state 93.82 10.00 1179 402958 467501 109717661
Laryngeal cancer 93.29 10.00 49 404088 730 110184432
Cardio-respiratory arrest 92.93 10.00 176 403961 115660 110069502
Cardiac arrest 92.42 10.00 387 403750 196366 109988796
Gallbladder cancer stage II 92.31 10.00 20 404117 0 110185162
Hip arthroplasty 90.99 10.00 45 404092 55768 110129394
Red blood cell sedimentation rate increased 90.94 10.00 91 404046 78211 110106951
Drug intolerance 90.46 10.00 999 403138 405513 109779649
COVID-19 pneumonia 89.95 10.00 14 404123 37129 110148033
Gait disturbance 88.76 10.00 623 403514 277585 109907577
Colitis ulcerative 88.61 10.00 91 404046 77272 110107890
Nail disorder 88.58 10.00 433 403704 57502 110127660
Hepatic function abnormal 88.34 10.00 118 404019 89177 110095985
Hypoglycaemia 88.32 10.00 182 403955 115922 110069240
Renal failure 88.09 10.00 477 403660 226097 109959065
Therapeutic product effect incomplete 87.66 10.00 470 403667 223335 109961827
Somnolence 87.29 10.00 682 403455 296767 109888395
Bacterial test 86.43 10.00 54 404083 1135 110184027
Drug eruption 86.37 10.00 44 404093 53615 110131547
Swelling 85.30 10.00 845 403292 350196 109834966
Hyponatraemia 84.73 10.00 458 403679 217195 109967967
Systemic lupus erythematosus 83.88 10.00 564 403573 253774 109931388
Rectal haemorrhage 83.62 10.00 197 403940 119636 110065526
Gallbladder cancer stage III 83.08 10.00 18 404119 0 110185162
Poisoning deliberate 82.83 10.00 3 404134 26328 110158834
Pleural effusion 82.56 10.00 351 403786 177358 110007804
Delirium 81.99 10.00 238 403899 134787 110050375
Hand deformity 81.68 10.00 466 403671 218040 109967122
Suicidal ideation 81.41 10.00 136 404001 93801 110091361
Disease recurrence 81.04 10.00 62 404075 60722 110124440
Serotonin syndrome 80.59 10.00 59 404078 59094 110126068
Lower limb fracture 80.37 10.00 94 404043 75254 110109908
Bladder cancer recurrent 80.09 10.00 40 404097 533 110184629
Liver disorder 79.77 10.00 260 403877 141983 110043179
Road traffic accident 79.47 10.00 171 403966 107227 110077935
Rash 78.17 10.00 2344 401793 818620 109366542
Colitis 78.16 10.00 160 403977 102163 110082999
Gastrointestinal haemorrhage 78.08 10.00 325 403812 165193 110019969
Neuroleptic malignant syndrome 77.74 10.00 15 404122 34044 110151118
Dizziness 76.61 10.00 1954 402183 696239 109488923
Erythema 76.56 10.00 1493 402644 289954 109895208
Malaise 76.46 10.00 1870 402267 669949 109515213
Foetal death 76.10 10.00 176 403961 15869 110169293
Cardiac failure congestive 75.98 10.00 289 403848 150711 110034451
Wrong technique in product usage process 75.20 10.00 127 404010 87221 110097941
Full blood count abnormal 74.95 10.00 57 404080 55995 110129167
Monocyte percentage increased 74.26 10.00 64 404073 2239 110182923
Musculoskeletal stiffness 74.21 10.00 659 403478 279163 109905999
Inappropriate schedule of product administration 74.12 10.00 438 403699 203199 109981963
Tongue carcinoma stage I 73.85 10.00 16 404121 0 110185162
Anal cancer stage III 73.85 10.00 16 404121 0 110185162
Agranulocytosis 73.78 10.00 70 404067 61690 110123472
Treatment failure 73.48 10.00 653 403484 276581 109908581
Cytomegalovirus infection 73.27 10.00 55 404082 54389 110130773
Contusion 72.75 10.00 526 403611 232835 109952327
Injection site erythema 72.16 10.00 147 403990 94029 110091133
Cholestasis 71.52 10.00 78 404059 64440 110120722
Syncope 71.43 10.00 440 403697 202096 109983066
Neuroendocrine carcinoma 71.41 10.00 42 404095 788 110184374
Hypokalaemia 70.41 10.00 385 403752 182063 110003099
Flushing 70.31 10.00 637 403500 104099 110081063
Aspartate aminotransferase increased 70.00 10.00 323 403814 159613 110025549
Haemoglobin urine present 69.44 10.00 43 404094 889 110184273
Laryngeal cancer stage IV 69.43 10.00 17 404120 12 110185150
Anal cancer stage II 69.23 10.00 15 404122 0 110185162
Cervix carcinoma stage 0 68.32 10.00 29 404108 258 110184904
Nasopharyngitis 67.78 10.00 1023 403114 393338 109791824
Haemorrhage 67.77 10.00 184 403953 106508 110078654
Sciatica 67.63 10.00 148 403989 92251 110092911
Intentional self-injury 67.63 10.00 26 404111 37403 110147759
Tenosynovitis stenosans 66.92 10.00 74 404063 3529 110181633
Therapy partial responder 66.54 10.00 26 404111 37035 110148127
Deep vein thrombosis postoperative 65.38 10.00 72 404065 59219 110125943
Bacterial test positive 65.24 10.00 110 404027 7867 110177295
Dry skin 65.17 10.00 190 403947 107463 110077699
Red blood cell sedimentation rate abnormal 64.73 10.00 7 404130 24502 110160660
Head and neck cancer stage IV 64.62 10.00 14 404123 0 110185162
Blood glucose increased 63.84 10.00 258 403879 132238 110052924
Sleep disorder due to a general medical condition 63.50 10.00 58 404079 52054 110133108
Mobility decreased 63.45 10.00 558 403579 236864 109948298
Abdominal discomfort 63.21 10.00 1035 403102 392823 109792339
Pneumocystis jirovecii pneumonia 63.08 10.00 39 404098 42696 110142466
Drug reaction with eosinophilia and systemic symptoms 63.02 10.00 128 404009 81967 110103195
Ascites 62.83 10.00 155 403982 92653 110092509
Computerised tomogram thorax 62.74 10.00 33 404104 493 110184669
Bronchitis 62.46 10.00 328 403809 156704 110028458
Stomatitis 62.12 10.00 659 403478 269583 109915579
Eosinophilia 62.09 10.00 72 404065 57864 110127298
Device expulsion 61.85 10.00 18 404119 30873 110154289
Sopor 61.82 10.00 28 404109 36518 110148644
Cerebral infarction 61.63 10.00 59 404078 51779 110133383
Nasopharyngeal cancer 61.60 10.00 24 404113 167 110184995
Pericardial effusion 61.43 10.00 71 404066 57146 110128016
Shock 61.40 10.00 63 404074 53525 110131637
Myocarditis 61.13 10.00 17 404120 30038 110155124
Chest pain 61.08 10.00 987 403150 375388 109809774
Anaphylactic reaction 60.63 10.00 662 403475 113638 110071524
Pulmonary fibrosis 60.40 10.00 182 403955 101860 110083302
Acute myeloid leukaemia 60.22 10.00 32 404105 38078 110147084
Pregnancy 59.70 10.00 59 404078 51008 110134154
Glossodynia 59.66 10.00 521 403616 221483 109963679
Loss of employment 59.23 10.00 67 404070 3277 110181885
Orthostatic hypotension 59.20 10.00 94 404043 66155 110119007
Oesophageal cancer metastatic 59.18 10.00 27 404110 290 110184872
Pain in extremity 58.93 10.00 1343 402794 485775 109699387
Skin exfoliation 58.86 10.00 147 403990 87504 110097658
Intentional product use issue 58.83 10.00 600 403537 247306 109937856
Haemophagocytic lymphohistiocytosis 58.57 10.00 21 404116 31538 110153624
Abortion spontaneous 58.41 10.00 26 404111 34256 110150906
Computerised tomogram thorax abnormal 58.23 10.00 61 404076 2734 110182428
Illness 58.20 10.00 134 404003 82037 110103125
Bile duct cancer stage IV 57.70 10.00 14 404123 9 110185153
Autoimmune disorder 57.49 10.00 94 404043 65389 110119773
Posterior reversible encephalopathy syndrome 57.19 10.00 26 404111 33835 110151327
Anti-cyclic citrullinated peptide antibody positive 56.81 10.00 410 403727 181574 110003588
Prescribed underdose 56.81 10.00 94 404043 65080 110120082
Synovial fluid analysis 56.73 10.00 59 404078 2622 110182540
Product dose omission in error 56.62 10.00 9 404128 23503 110161659
Therapeutic product effect decreased 56.47 10.00 595 403542 243721 109941441
Blood urine present 56.43 10.00 206 403931 24039 110161123
Incorrect route of product administration 56.20 10.00 92 404045 63969 110121193
Peripheral swelling 56.18 10.00 1089 403048 402945 109782217
Mastocytosis 56.02 10.00 36 404101 796 110184366
Small intestine carcinoma stage 0 55.39 10.00 12 404125 0 110185162
Aphasia 55.32 10.00 81 404056 58916 110126246
Bone erosion 54.87 10.00 53 404084 46318 110138844
Influenza 54.73 10.00 377 403760 168724 110016438
Cytomegalovirus infection reactivation 54.68 10.00 3 404134 18330 110166832
Rash erythematous 54.57 10.00 497 403640 81335 110103827
Procedural pain 54.55 10.00 31 404106 35534 110149628
Accidental overdose 53.86 10.00 66 404071 51768 110133394
Drug use disorder 53.78 10.00 3 404134 18071 110167091
Alanine aminotransferase increased 53.58 10.00 422 403715 183351 110001811
Gamma-glutamyltransferase decreased 53.14 10.00 27 404110 374 110184788
Acute respiratory failure 53.08 10.00 123 404014 75137 110110025
Macular degeneration 52.82 10.00 8 404129 21651 110163511
Blood creatine phosphokinase increased 52.70 10.00 118 404019 72959 110112203
Pruritus 52.69 10.00 1671 402466 579889 109605273
Gastrointestinal stromal tumour 52.63 10.00 51 404086 2080 110183082
Osteoporosis 52.62 10.00 154 403983 86998 110098164
Cardiogenic shock 52.53 10.00 80 404057 57258 110127904
Ear infection 52.37 10.00 93 404044 62639 110122523
Cataract 52.06 10.00 135 404002 79350 110105812
Staphylococcal infection 52.04 10.00 111 404026 69833 110115329
Onychomycosis 51.93 10.00 278 403859 38253 110146909
Cerebral haemorrhage 51.85 10.00 99 404038 64869 110120293
Abdominal pain 51.66 10.00 1453 402684 511536 109673626
Seizure 51.38 10.00 538 403599 220647 109964515
Poisoning 51.30 10.00 21 404116 29084 110156078
Aspergillus infection 51.15 10.00 15 404122 25601 110159561
Rectal cancer stage III 51.04 10.00 13 404124 13 110185149
Agitation 50.85 10.00 226 403911 112825 110072337
Bladder cancer stage I, without cancer in situ 50.77 10.00 11 404126 0 110185162
Neuropathy peripheral 50.74 10.00 415 403722 178862 110006300
Nasopharyngeal cancer stage IV 50.54 10.00 12 404125 6 110185156
Spinal cord neoplasm 50.47 10.00 29 404108 520 110184642
Arrhythmia 50.46 10.00 112 404025 69463 110115699
Victim of child abuse 50.30 10.00 39 404098 1172 110183990
Acute myocardial infarction 49.88 10.00 149 403988 83628 110101534
Pemphigus 49.81 10.00 522 403615 214048 109971114
Hepatic failure 49.57 10.00 111 404026 68628 110116534
C-reactive protein abnormal 49.31 10.00 275 403862 129420 110055742
Anal cancer 49.20 10.00 33 404104 786 110184376
Sedation complication 49.19 10.00 7 404130 19848 110165314
Ischaemic stroke 49.01 10.00 47 404090 41216 110143946
Myelodysplastic syndrome 49.00 10.00 39 404098 37445 110147717
Bone marrow failure 48.98 10.00 85 404052 57763 110127399
Platelet count decreased 48.97 10.00 572 403565 229871 109955291
Product quality issue 48.79 10.00 464 403673 76835 110108327
Eczema 48.73 10.00 121 404016 72172 110112990
C-reactive protein 48.62 10.00 25 404112 30306 110154856
Urine ketone body present 48.60 10.00 65 404072 3781 110181381
Haematoma 48.53 10.00 87 404050 58389 110126773
Generalised tonic-clonic seizure 48.47 10.00 78 404059 54602 110130560
Dysarthria 48.39 10.00 152 403985 83969 110101193
Subarachnoid haemorrhage 48.33 10.00 24 404113 29678 110155484
Wound 48.26 10.00 586 403551 233851 109951311
Adverse drug reaction 48.09 10.00 210 403927 105349 110079813
Device issue 47.62 10.00 34 404103 34501 110150661
Nitrite urine present 47.48 10.00 38 404099 1197 110183965
Adverse event 47.45 10.00 220 403917 108589 110076573
Muscle spasticity 47.41 10.00 37 404100 35878 110149284
Vasculitis 47.30 10.00 37 404100 35836 110149326
Anti-cyclic citrullinated peptide antibody 47.28 10.00 8 404129 19956 110165206
Adrenal insufficiency 47.26 10.00 51 404086 42339 110142823
Diabetes mellitus 46.94 10.00 195 403942 99186 110085976
Pericarditis 46.90 10.00 543 403594 218571 109966591
Hypercalcaemia 46.82 10.00 61 404076 46596 110138566
Pathogen resistance 46.79 10.00 5 404132 17667 110167495
Infusion site coldness 46.60 10.00 22 404115 257 110184905
Laryngeal cancer stage III 46.49 10.00 13 404124 24 110185138
Duodenal ulcer perforation 46.43 10.00 420 403717 177280 110007882
Subdural haematoma 46.32 10.00 39 404098 36415 110148747
Gallbladder cancer stage 0 46.16 10.00 10 404127 0 110185162
Epiglottic cancer 46.16 10.00 10 404127 0 110185162
Pulmonary oedema 46.01 10.00 200 403937 100459 110084703
Device malfunction 45.77 10.00 18 404119 25540 110159622
Bacterial infection 45.37 10.00 61 404076 45975 110139187
Coronary artery disease 45.26 10.00 124 404013 71566 110113596
Acute respiratory distress syndrome 45.19 10.00 78 404059 53120 110132042
Acute hepatic failure 45.14 10.00 40 404097 36428 110148734
Panniculitis 45.12 10.00 3 404134 15579 110169583
Perfume sensitivity 45.02 10.00 35 404102 1056 110184106
Gastrointestinal disorder 44.92 10.00 618 403519 241334 109943828
Neurotoxicity 44.64 10.00 53 404084 42154 110143008
Endometrial cancer stage I 44.28 10.00 19 404118 174 110184988
Diabetic ketoacidosis 44.28 10.00 53 404084 42005 110143157
Hepatocellular injury 44.17 10.00 73 404064 50569 110134593
Drug tolerance decreased 43.70 10.00 23 404114 27517 110157645
Coma 43.69 10.00 252 403885 117617 110067545
Miosis 43.66 10.00 13 404124 21970 110163192
Rectal cancer stage II 43.54 10.00 10 404127 3 110185159
Device difficult to use 43.52 10.00 8 404129 18797 110166365
Palpitations 43.49 10.00 372 403765 158840 110026322
Carcinoid tumour 43.19 10.00 27 404110 568 110184594
Productive cough 43.11 10.00 243 403894 114062 110071100
Respiratory tract infection 42.91 10.00 127 404010 71490 110113672
Haemodynamic instability 42.87 10.00 15 404122 22873 110162289
Epidural lipomatosis 42.86 10.00 45 404092 2022 110183140
Intraductal proliferative breast lesion 42.84 10.00 53 404084 2852 110182310
Pneumonitis 42.82 10.00 140 403997 76391 110108771
Tinnitus 42.65 10.00 99 404038 60441 110124721
Back injury 42.51 10.00 308 403829 47091 110138071
Thrombotic microangiopathy 42.47 10.00 27 404110 29122 110156040
Status epilepticus 42.34 10.00 32 404105 31539 110153623
Cytomegalovirus viraemia 42.33 10.00 7 404130 17757 110167405
Child abuse 42.18 10.00 31 404106 858 110184304
Respiratory arrest 42.15 10.00 94 404043 58205 110126957
Osteonecrosis of jaw 42.08 10.00 69 404068 47948 110137214
Brain stem glioma 41.89 10.00 19 404118 201 110184961
Pulmonary alveolar haemorrhage 41.73 10.00 11 404126 20139 110165023
Joint dislocation 41.72 10.00 38 404099 34152 110151010
Herpes zoster 41.64 10.00 229 403908 108150 110077012
Urticaria 41.44 10.00 1489 402648 317368 109867794
Device dislocation 41.42 10.00 33 404104 31671 110153491
Finger deformity 41.41 10.00 234 403903 32858 110152304
Delusion of grandeur 41.26 10.00 46 404091 2214 110182948
Specific gravity urine increased 40.88 10.00 25 404112 505 110184657
Hemiplegia 40.87 10.00 16 404121 22766 110162396
Medication error 40.83 10.00 222 403915 105144 110080018
Aggression 40.77 10.00 98 404039 59112 110126050
Vulval cancer 40.53 10.00 26 404111 573 110184589
Localised infection 40.47 10.00 59 404078 42989 110142173
Congenital hydrocephalus 40.12 10.00 14 404123 68 110185094
Nasal sinus cancer 40.12 10.00 14 404123 68 110185094
Pleuritic pain 40.01 10.00 140 403997 16000 110169162
Nephrolithiasis 39.97 10.00 117 404020 66095 110119067
Cytopenia 39.79 10.00 31 404106 30085 110155077
Cellulitis 39.76 10.00 283 403854 125733 110059429
Hyperglycaemia 39.54 10.00 168 403969 84922 110100240
Disseminated intravascular coagulation 39.39 10.00 56 404081 41230 110143932
Overdose 39.27 10.00 609 403528 233185 109951977
Clostridium difficile colitis 39.22 10.00 62 404075 43716 110141446
Parkinsonism 39.12 10.00 16 404121 22171 110162991
Second primary malignancy 39.10 10.00 9 404128 18059 110167103
Frequent bowel movements 38.98 10.00 132 404005 71258 110113904
Femur fracture 38.88 10.00 64 404073 44405 110140757
Epilepsy 38.73 10.00 547 403590 99662 110085500
Ureteric cancer 38.61 10.00 20 404117 289 110184873
Lymphocyte count abnormal 38.61 10.00 46 404091 2380 110182782
Adjustment disorder with depressed mood 38.52 10.00 63 404074 43820 110141342
Sarcoma 38.48 10.00 31 404106 986 110184176
Cardiac disorder 38.36 10.00 146 403991 76134 110109028
Hepatic cirrhosis 38.33 10.00 123 404014 67503 110117659
Creatinine renal clearance decreased 38.03 10.00 16 404121 21799 110163363
Sense of oppression 38.02 10.00 38 404099 1610 110183552
Drug level increased 37.83 10.00 73 404064 47646 110137516
Pulmonary hypertension 37.55 10.00 92 404045 55128 110130034
Haematotoxicity 37.50 10.00 15 404122 21067 110164095
Dystonia 37.47 10.00 24 404113 25781 110159381
Maternal exposure during pregnancy 37.25 10.00 681 403456 254202 109930960
Malignant neoplasm of spinal cord 37.14 10.00 14 404123 88 110185074
Bilirubin urine present 36.93 10.00 20 404117 318 110184844
Tongue cancer metastatic 36.92 10.00 8 404129 0 110185162
Laryngeal cancer stage II 36.92 10.00 8 404129 0 110185162
Malignant splenic neoplasm 36.92 10.00 8 404129 0 110185162
Nasal polyps 36.91 10.00 3 404134 13197 110171965
Helicobacter infection 36.90 10.00 456 403681 181421 110003741
Bile duct cancer 36.84 10.00 31 404106 1049 110184113
Labelled drug-drug interaction medication error 36.44 10.00 32 404105 29270 110155892
Deformity 36.21 10.00 100 404037 10060 110175102
Female genital tract fistula 36.20 10.00 8 404129 16511 110168651
Hypogammaglobulinaemia 36.18 10.00 14 404123 20062 110165100
Unresponsive to stimuli 36.17 10.00 116 404021 63674 110121488
Hepatotoxicity 36.15 10.00 115 404022 63285 110121877
Blood pressure increased 36.00 10.00 696 403441 257677 109927485
Injection site swelling 36.00 10.00 111 404026 61679 110123483
Allergy to chemicals 35.75 10.00 52 404085 3273 110181889
Specific gravity urine decreased 35.64 10.00 28 404109 858 110184304
Bronchopulmonary aspergillosis 35.49 10.00 34 404103 29829 110155333
Dermatitis atopic 35.41 10.00 25 404112 25516 110159646
Mitral valve incompetence 35.09 10.00 42 404095 33287 110151875
Motor dysfunction 35.02 10.00 23 404114 24383 110160779
Cough 34.97 10.00 1356 402781 460285 109724877
Lymphadenopathy 34.87 10.00 118 404019 63717 110121445
Pneumonia bacterial 34.73 10.00 27 404110 26234 110158928
Scleritis 34.46 10.00 67 404070 5353 110179809
Transient ischaemic attack 34.46 10.00 119 404018 63863 110121299
Rectal cancer stage IV 34.39 10.00 8 404129 3 110185159
Abnormal behaviour 34.31 10.00 56 404081 38983 110146179
Skin necrosis 34.08 10.00 18 404119 21494 110163668
Dyskinesia 33.98 10.00 87 404050 51359 110133803
Hypothyroidism 33.83 10.00 144 403993 72755 110112407
Mental status changes 33.73 10.00 153 403984 75969 110109193
Proctitis 33.64 10.00 10 404127 16917 110168245
Band neutrophil percentage increased 33.60 10.00 20 404117 384 110184778
Affect lability 33.58 10.00 13 404124 18624 110166538
International normalised ratio increased 33.52 10.00 183 403954 86589 110098573
Cardiotoxicity 33.50 10.00 10 404127 16871 110168291
Cardiomyopathy 33.46 10.00 44 404093 33481 110151681
Fracture 33.41 10.00 25 404112 24763 110160399
Immune reconstitution inflammatory syndrome 33.33 10.00 9 404128 16217 110168945
Injection site haemorrhage 33.33 10.00 43 404094 32985 110152177
Product storage error 33.24 10.00 19 404118 21709 110163453
Impaired healing 33.18 10.00 512 403625 196205 109988957
Myalgia 33.17 10.00 592 403545 221789 109963373
Product administration error 33.07 10.00 53 404084 37164 110147998
Hepatic enzyme 33.04 10.00 64 404073 5099 110180063
Blood calcium decreased 32.84 10.00 50 404087 35795 110149367
Angina pectoris 32.79 10.00 117 404020 62178 110122984
Muscle rigidity 32.69 10.00 24 404113 24007 110161155
Maternal exposure timing unspecified 32.68 10.00 18 404119 20995 110164167
Dyspnoea exertional 32.68 10.00 234 403903 103826 110081336
Graft versus host disease 32.45 10.00 14 404123 18792 110166370
Haemolytic anaemia 32.42 10.00 18 404119 20902 110164260
Melaena 32.42 10.00 135 404002 68622 110116540
Thrombosis 32.38 10.00 248 403889 108414 110076748
Follicular lymphoma stage III 32.31 10.00 7 404130 0 110185162
Skin haemorrhage 32.24 10.00 26 404111 24801 110160361
Arteriosclerosis 32.08 10.00 26 404111 24741 110160421
Venoocclusive liver disease 32.07 10.00 8 404129 15199 110169963
Unevaluable event 32.00 10.00 110 404027 59117 110126045
Respiratory disorder 31.91 10.00 143 403994 71239 110113923
Enthesopathy 31.87 10.00 4 404133 12474 110172688
Haematuria 31.55 10.00 176 403961 82829 110102333
Balance disorder 31.54 10.00 273 403864 116287 110068875
Injection site pruritus 31.36 10.00 90 404047 51168 110133994
Progressive multifocal leukoencephalopathy 31.34 10.00 27 404110 24929 110160233
Blood uric acid increased 31.29 10.00 20 404117 21509 110163653
Skin fissures 31.28 10.00 26 404111 24432 110160730
Shock haemorrhagic 31.25 10.00 32 404105 27215 110157947
Insomnia 31.20 10.00 1042 403095 359548 109825614
Surgery 31.14 10.00 65 404072 41218 110143944
Mean cell haemoglobin decreased 31.11 10.00 76 404061 7098 110178064
Loss of consciousness 31.08 10.00 517 403620 195789 109989373
Clear cell renal cell carcinoma 30.95 10.00 44 404093 2712 110182450
Metastases to liver 30.87 10.00 51 404086 35335 110149827
Cells in urine 30.84 10.00 15 404122 188 110184974
Exposure to toxic agent 30.79 10.00 5 404132 12853 110172309
Thyroxine free increased 30.72 10.00 32 404105 1425 110183737
Retinitis 30.69 10.00 44 404093 32283 110152879
Brain neoplasm 30.59 10.00 70 404067 6267 110178895
Head injury 30.58 10.00 70 404067 42947 110142215
Hospitalisation 30.53 10.00 353 403784 142140 110043022
Arterial occlusive disease 30.50 10.00 9 404128 15299 110169863
Bladder cancer stage 0, with cancer in situ 30.48 10.00 11 404126 60 110185102
Head and neck cancer 30.36 10.00 18 404119 343 110184819
Visual acuity reduced 30.33 10.00 44 404093 32129 110153033
Nightmare 30.33 10.00 60 404077 38803 110146359
Hyperphosphataemia 30.23 10.00 11 404126 16370 110168792
Splenomegaly 30.17 10.00 27 404110 24471 110160691
Hypervolaemia 30.14 10.00 87 404050 49373 110135789
Lupus-like syndrome 30.13 10.00 65 404072 40727 110144435
Myasthenia gravis 29.89 10.00 21 404116 21490 110163672
Chronic lymphocytic leukaemia stage 1 29.82 10.00 7 404130 3 110185159
Premature delivery 29.77 10.00 41 404096 30591 110154571
Blister 29.73 10.00 619 403518 226757 109958405
Toxic skin eruption 29.69 10.00 34 404103 27481 110157681
Ankylosing spondylitis 29.64 10.00 10 404127 15602 110169560
Rheumatoid arthritis 29.52 10.00 851 403286 298762 109886400
Splenic neoplasm malignancy unspecified 29.45 10.00 10 404127 44 110185118
Uveitis 29.12 10.00 22 404115 21688 110163474
Akathisia 29.12 10.00 13 404124 17100 110168062
No adverse event 28.92 10.00 155 403982 73684 110111478
Hypocholesterolaemia 28.89 10.00 69 404068 6352 110178810
Blood alkaline phosphatase increased 28.85 10.00 147 403990 70788 110114374
Drug effective for unapproved indication 28.84 10.00 8 404129 14159 110171003
Acute graft versus host disease 28.72 10.00 6 404131 12875 110172287
Malignant peritoneal neoplasm 28.59 10.00 23 404114 730 110184432
Blood thyroid stimulating hormone decreased 28.58 10.00 74 404063 7165 110177997
Klebsiella infection 28.52 10.00 19 404118 19990 110165172
Polyarthritis 28.41 10.00 17 404120 18946 110166216
Tremor 28.40 10.00 544 403593 201688 109983474
Toothache 28.38 10.00 165 403972 23410 110161752
Pulmonary arterial hypertension 28.35 10.00 47 404090 32521 110152641
Infusion related reaction 28.12 10.00 1123 403014 380039 109805123
X-ray abnormal 27.93 10.00 61 404076 38056 110147106
Injection site urticaria 27.88 10.00 14 404123 17201 110167961
Breath sounds abnormal 27.84 10.00 31 404106 25373 110159789
Endometrial cancer stage III 27.69 10.00 6 404131 0 110185162
Bile duct cancer stage III 27.69 10.00 6 404131 0 110185162
Cardiac neoplasm malignant 27.69 10.00 6 404131 0 110185162
Anal cancer stage I 27.69 10.00 6 404131 0 110185162
Stress 27.51 10.00 249 403888 105099 110080063
Infective pulmonary exacerbation of cystic fibrosis 27.49 10.00 117 404020 14654 110170508
Product label confusion 27.49 10.00 159 403978 22518 110162644
Anosmia 27.41 10.00 6 404131 12466 110172696
Peripheral venous disease 27.41 10.00 446 403691 83671 110101491
Respiratory tract congestion 27.36 10.00 44 404093 30813 110154349
Escherichia infection 27.28 10.00 28 404109 23788 110161374
Therapy cessation 27.27 10.00 79 404058 44778 110140384
Arteriosclerosis coronary artery 27.14 10.00 31 404106 25087 110160075
Tri-iodothyronine free increased 27.02 10.00 15 404122 251 110184911
Joint stiffness 26.98 10.00 140 403997 67103 110118059
Blood cholesterol 26.94 10.00 24 404113 878 110184284
Restlessness 26.81 10.00 110 404027 56149 110129013
Reversible airways obstruction 26.75 10.00 39 404098 2460 110182702
Radiculopathy 26.71 10.00 19 404118 19317 110165845
Tongue neoplasm 26.71 10.00 12 404125 124 110185038
Electrocardiogram QT prolonged 26.54 10.00 262 403875 108698 110076464
Coagulopathy 26.39 10.00 70 404067 40841 110144321
Anuria 26.35 10.00 30 404107 24311 110160851
Coordination abnormal 26.34 10.00 32 404105 25196 110159966
Oropharyngeal oedema 26.18 10.00 18 404119 447 110184715
Blood pressure fluctuation 26.13 10.00 163 403974 74661 110110501
Pulmonary thrombosis 26.11 10.00 9 404128 13854 110171308
Intentional dose omission 26.11 10.00 21 404116 20059 110165103
Clostridium difficile infection 26.06 10.00 100 404037 52029 110133133
Sinus disorder 26 10.00 50 404087 32678 110152484
Urinary casts 25.86 10.00 28 404109 1304 110183858
Eye disorder 25.84 10.00 41 404096 28865 110156297
Transplant rejection 25.82 10.00 31 404106 24536 110160626
Muscle tension dysphonia 25.71 10.00 15 404122 277 110184885
Disorientation 25.70 10.00 152 403985 70519 110114643
Diffuse large B-cell lymphoma 25.64 10.00 13 404124 15885 110169277
Sleep disorder 25.61 10.00 542 403595 198102 109987060
Anxiety 25.60 10.00 1016 403121 344062 109841100
Renal tubular necrosis 25.60 10.00 45 404092 30430 110154732
Salivary hypersecretion 25.57 10.00 16 404121 17405 110167757
Osteonecrosis 25.56 10.00 53 404084 33688 110151474
Sudden death 25.41 10.00 31 404106 24364 110160798
Drug withdrawal syndrome 25.40 10.00 64 404073 37990 110147172
Tumour lysis syndrome 25.40 10.00 46 404091 30755 110154407
Band neutrophil count increased 25.38 10.00 21 404116 694 110184468
Pancreatitis 25.33 10.00 219 403918 93314 110091848
Eosinophil percentage increased 25.18 10.00 30 404107 1552 110183610
Tuberculosis 25.17 10.00 17 404120 17757 110167405
Red cell distribution width increased 25.10 10.00 129 404008 17473 110167689
Lupus vulgaris 25.02 10.00 54 404083 33829 110151333
Cestode infection 24.97 10.00 15 404122 293 110184869
Right ventricular failure 24.96 10.00 35 404102 25919 110159243
Bundle branch block right 24.91 10.00 7 404130 12284 110172878
Synovial cyst 24.84 10.00 95 404042 11335 110173827
White blood cell count increased 24.80 10.00 230 403907 96612 110088550
Urine leukocyte esterase 24.67 10.00 13 404124 195 110184967
Cystitis haemorrhagic 24.65 10.00 7 404130 12202 110172960
Glycosylated haemoglobin increased 24.61 10.00 30 404107 23589 110161573
Vision blurred 24.49 10.00 328 403809 128694 110056468
Exostosis 24.39 10.00 86 404051 45870 110139292
Eye pruritus 24.39 10.00 52 404085 32723 110152439
Hip fracture 24.34 10.00 58 404079 35093 110150069
Respiratory acidosis 24.33 10.00 10 404127 13816 110171346
Blood bilirubin increased 24.26 10.00 170 403967 75802 110109360
Tricuspid valve incompetence 24.17 10.00 31 404106 23842 110161320
Gastric cancer recurrent 24.17 10.00 8 404129 32 110185130
Endometrial cancer 24.16 10.00 37 404100 2439 110182723
Adjustment disorder 24.12 10.00 5 404132 10790 110174372
Delusion 23.89 10.00 31 404106 23724 110161438
Blood creatinine increased 23.87 10.00 498 403639 182391 110002771
BK virus infection 23.85 10.00 9 404128 13097 110172065
Impaired quality of life 23.72 10.00 46 404091 29971 110155191
Catatonia 23.72 10.00 6 404131 11294 110173868
Foot deformity 23.60 10.00 94 404043 48386 110136776
Urine oxalate increased 23.55 10.00 13 404124 215 110184947
Malignant melanoma 23.54 10.00 123 404014 16768 110168394
Tachycardia 23.53 10.00 639 403498 226006 109959156
Treatment noncompliance 23.47 10.00 163 403974 72827 110112335
Oesophageal polyp 23.46 10.00 10 404127 90 110185072
Psychotic disorder 23.40 10.00 101 404036 50836 110134326
Neurological symptom 23.38 10.00 14 404123 15594 110169568
Cognitive disorder 23.21 10.00 206 403931 87305 110097857
Enterocolitis 23.19 10.00 21 404116 18928 110166234
Joint injury 23.19 10.00 72 404065 39922 110145240
Hepatic enzyme increased 23.11 10.00 948 403189 319944 109865218
Injection site rash 23.11 10.00 31 404106 23388 110161774
Rhinalgia 23.09 10.00 47 404090 3882 110181280
Salivary gland cancer stage I 23.08 10.00 5 404132 0 110185162
Bile duct cancer stage II 23.08 10.00 5 404132 0 110185162
Head and neck cancer stage I 23.08 10.00 5 404132 0 110185162
Cystitis 22.98 10.00 144 403993 65892 110119270
Encephalitis 22.91 10.00 21 404116 18818 110166344
Urine bilirubin decreased 22.75 10.00 11 404126 136 110185026
Urinary retention 22.71 10.00 155 403982 69528 110115634
Muscle twitching 22.69 10.00 47 404090 29888 110155274
Endometrial cancer stage II 22.64 10.00 6 404131 8 110185154
Generalised oedema 22.61 10.00 49 404088 30655 110154507
Brain oedema 22.60 10.00 50 404087 31048 110154114
Drug hypersensitivity 22.55 10.00 1394 402743 452696 109732466
Hyperbilirubinaemia 22.55 10.00 49 404088 30622 110154540
Precancerous condition 22.54 10.00 18 404119 565 110184597
Ventricular tachycardia 22.47 10.00 100 404037 49909 110135253
Red blood cells urine 22.43 10.00 19 404118 649 110184513
Dislocation of vertebra 22.42 10.00 83 404054 43638 110141524
Abdominal pain lower 22.42 10.00 66 404071 37217 110147945
Neoplasm progression 22.41 10.00 141 403996 64454 110120708
Pyelonephritis 22.39 10.00 36 404101 25214 110159948
Rib fracture 22.39 10.00 57 404080 33713 110151449
Vertigo 22.38 10.00 206 403931 86664 110098498
Malnutrition 22.27 10.00 41 404096 27238 110157924
Sickle cell anaemia with crisis 22.22 10.00 4 404133 9541 110175621
Headache 22.21 10.00 2855 401282 879522 109305640
Blood parathyroid hormone decreased 22.18 10.00 10 404127 13079 110172083
Appendicitis 22.17 10.00 44 404093 28420 110156742
Liver function test abnormal 22.16 10.00 154 403983 68796 110116366
Hypertriglyceridaemia 22.15 10.00 16 404121 16138 110169024
Blindness 22.13 10.00 64 404073 36295 110148867
Injection site induration 22.12 10.00 7 404130 11376 110173786
Laryngitis 22.09 10.00 80 404057 42331 110142831
Hyperreflexia 22.03 10.00 4 404133 9481 110175681
Acute graft versus host disease in skin 21.98 10.00 6 404131 10734 110174428
Rectal cancer 21.89 10.00 45 404092 3744 110181418
Prostate cancer recurrent 21.86 10.00 22 404115 940 110184222
Breast disorder 21.77 10.00 34 404103 2280 110182882
Epistaxis 21.75 10.00 340 403797 130032 110055130
Magnesium deficiency 21.71 10.00 20 404117 765 110184397
Bradypnoea 21.54 10.00 3 404134 8646 110176516
Full blood count decreased 21.42 10.00 54 404083 32045 110153117
Immunosuppression 21.36 10.00 20 404117 17739 110167423
Colon cancer stage 0 21.34 10.00 7 404130 27 110185135
Juvenile idiopathic arthritis 21.29 10.00 59 404078 5948 110179214
Drug level below therapeutic 21.27 10.00 8 404129 11665 110173497
Irritability 21.24 10.00 96 404041 47713 110137449
Cushingoid 21.21 10.00 92 404045 11620 110173542
Rebound effect 21.18 10.00 14 404123 14792 110170370
Breast cancer in situ 21.17 10.00 24 404113 1177 110183985
Hyperlipidaemia 21.16 10.00 64 404073 35784 110149378
Transaminases increased 21.16 10.00 140 403997 63250 110121912
Diverticulitis 21.16 10.00 112 404025 53410 110131752
Mean cell haemoglobin concentration increased 21.16 10.00 23 404114 1076 110184086
Therapeutic response shortened 21.14 10.00 48 404089 29535 110155627
Mast cell activation syndrome 21.14 10.00 27 404110 1501 110183661
Dissociation 21.10 10.00 5 404132 9837 110175325
Intentional product misuse 21.04 10.00 350 403787 132554 110052608
Lipaemic index score 21.02 10.00 10 404127 119 110185043
Hyperammonaemia 21.02 10.00 12 404125 13720 110171442
Methaemoglobinaemia 21.00 10.00 4 404133 9164 110175998
Injection site bruising 20.98 10.00 106 404031 51157 110134005
Lung cancer metastatic 20.96 10.00 47 404090 4151 110181011
Adverse reaction 20.89 10.00 182 403955 29412 110155750
Myoclonus 20.88 10.00 57 404080 32941 110152221
Iron deficiency 20.85 10.00 22 404115 18454 110166708
Upper respiratory tract infection 20.83 10.00 628 403509 130700 110054462
Bronchopulmonary aspergillosis allergic 20.81 10.00 73 404064 8353 110176809
Ill-defined disorder 20.79 10.00 426 403711 156427 110028735
Pallor 20.77 10.00 121 404016 56346 110128816
Hallucination 20.68 10.00 254 403883 101178 110083984
Sleep apnoea syndrome 20.60 10.00 77 404060 40370 110144792
Tendon rupture 20.57 10.00 13 404124 14065 110171097
Total lung capacity decreased 20.57 10.00 65 404072 7049 110178113
Neuralgia 20.56 10.00 99 404038 48379 110136783
Leiomyosarcoma 20.48 10.00 15 404122 413 110184749
Dysphonia 20.46 10.00 178 403959 75751 110109411
Musculoskeletal disorder 20.40 10.00 32 404105 22632 110162530
Carcinoid syndrome 20.37 10.00 13 404124 284 110184878
Spinal fracture 20.33 10.00 32 404105 22601 110162561
Cardiac murmur 20.12 10.00 37 404100 24591 110160571
Malignant neoplasm of ampulla of Vater 20.06 10.00 7 404130 34 110185128
Haemoglobin decreased 20.06 10.00 725 403412 248002 109937160
Endophthalmitis 20.02 10.00 3 404134 8184 110176978
Antinuclear antibody 19.86 10.00 15 404122 433 110184729
Mucormycosis 19.85 10.00 7 404130 10621 110174541
Cardiac failure chronic 19.84 10.00 13 404124 13798 110171364
Candida infection 19.80 10.00 99 404038 47910 110137252
Immunosuppressant drug level increased 19.80 10.00 9 404128 11715 110173447
Amnesia 19.63 10.00 269 403868 105139 110080023
Inappropriate antidiuretic hormone secretion 19.58 10.00 61 404076 33790 110151372
White blood cell count decreased 19.56 10.00 664 403473 228726 109956436
Rhinitis allergic 19.50 10.00 22 404115 17900 110167262
Abortion induced 19.47 10.00 3 404134 8016 110177146
Drug level above therapeutic 19.41 10.00 9 404128 11579 110173583
Jaundice cholestatic 19.34 10.00 15 404122 14593 110170569
Chronic sinusitis 19.34 10.00 39 404098 25045 110160117
Blood pressure decreased 19.25 10.00 300 403837 114791 110070371
Proteinuria 19.22 10.00 78 404059 39940 110145222
Thyroxine free decreased 19.20 10.00 23 404114 1197 110183965
Atelectasis 19.17 10.00 212 403925 36500 110148662
Normochromic normocytic anaemia 19.15 10.00 12 404125 13045 110172117
Renal cancer recurrent 19.00 10.00 9 404128 106 110185056
Lip neoplasm malignant stage unspecified 18.98 10.00 7 404130 41 110185121
Nasal congestion 18.96 10.00 249 403888 98033 110087129
Oroantral fistula 18.94 10.00 14 404123 391 110184771
Carbuncle 18.86 10.00 25 404112 1442 110183720
Lethargy 18.83 10.00 235 403902 93341 110091821
Metastatic carcinoma of the bladder 18.77 10.00 12 404125 263 110184899
Polymenorrhoea 18.71 10.00 22 404115 1122 110184040
Apathy 18.71 10.00 19 404118 16220 110168942
Rash maculo-papular 18.70 10.00 177 403960 74045 110111117
Blood loss anaemia 18.67 10.00 23 404114 18002 110167160
Behaviour disorder 18.63 10.00 6 404131 9641 110175521
Foot fracture 18.62 10.00 41 404096 25505 110159657
Cardiac tamponade 18.60 10.00 9 404128 11298 110173864
Nephrotic syndrome 18.57 10.00 14 404123 13817 110171345
Product administration interrupted 18.56 10.00 9 404128 11283 110173879
Personality disorder 18.55 10.00 12 404125 12825 110172337
Infusion site induration 18.54 10.00 24 404113 1352 110183810
Reflux gastritis 18.47 10.00 25 404112 1471 110183691
Head and neck cancer stage III 18.46 10.00 4 404133 0 110185162
Endocrine neoplasm malignant 18.46 10.00 4 404133 0 110185162
Nasopharyngeal cancer stage III 18.46 10.00 4 404133 0 110185162
Toxic encephalopathy 18.46 10.00 17 404120 15197 110169965
Osteomyelitis 18.43 10.00 70 404067 36530 110148632
Troponin increased 18.40 10.00 52 404085 29714 110155448
Vaginal discharge 18.39 10.00 23 404114 17885 110167277
Dysphagia 18.39 10.00 424 403713 153176 110031986
Product prescribing issue 18.38 10.00 12 404125 12760 110172402
Systemic mastocytosis 18.32 10.00 13 404124 340 110184822
Asphyxia 18.32 10.00 15 404122 14200 110170962
Left ventricular hypertrophy 18.31 10.00 13 404124 13231 110171931
Hyperthermia 18.24 10.00 31 404106 21241 110163921
Parosmia 18.14 10.00 13 404124 13167 110171995
Fungal infection 18.09 10.00 110 404027 50696 110134466
Graft versus host disease in skin 18.08 10.00 4 404133 8250 110176912
Colitis ischaemic 18.02 10.00 23 404114 17727 110167435
Tooth erosion 18.02 10.00 14 404123 422 110184740
Euglycaemic diabetic ketoacidosis 18.01 10.00 10 404127 11613 110173549
Demyelination 17.97 10.00 6 404131 9423 110175739
Premenstrual syndrome 17.86 10.00 16 404121 590 110184572
Visual impairment 17.85 10.00 365 403772 134063 110051099
Cholangitis 17.83 10.00 20 404117 16315 110168847
Myelocyte percentage increased 17.82 10.00 11 404126 226 110184936
Pulpitis dental 17.80 10.00 25 404112 1524 110183638
Pancreatitis acute 17.75 10.00 138 403999 60136 110125026
Bacteraemia 17.72 10.00 87 404050 42303 110142859
Lip pruritus 17.72 10.00 23 404114 1299 110183863
Emphysema 17.68 10.00 28 404109 19728 110165434
Walking aid user 17.66 10.00 41 404096 25034 110160128
Metastases to lung 17.66 10.00 36 404101 23027 110162135
Malignant neoplasm of thorax 17.62 10.00 5 404132 10 110185152
Pemphigoid 17.57 10.00 28 404109 19679 110165483
Substance abuse 17.54 10.00 12 404125 12451 110172711
Drug-induced liver injury 17.46 10.00 321 403816 119746 110065416
Gestational diabetes 17.41 10.00 3 404134 7386 110177776
Prostatomegaly 17.41 10.00 44 404093 4198 110180964
Cholestatic liver injury 17.37 10.00 3 404134 7373 110177789
Gamma-glutamyltransferase increased 17.30 10.00 142 403995 61167 110123995
Cardiac failure acute 17.26 10.00 39 404098 24039 110161123
Mouth ulceration 17.26 10.00 104 404033 48034 110137128
Catarrh 17.24 10.00 3 404134 7332 110177830
Spondylitis 17.22 10.00 10 404127 11328 110173834
Atrial tachycardia 17.22 10.00 6 404131 9172 110175990
Gastroenteritis 17.18 10.00 78 404059 38722 110146440
Enterococcal infection 17.17 10.00 30 404107 20336 110164826
Foot operation 17.16 10.00 3 404134 7310 110177852
Pneumopericardium 17.16 10.00 11 404126 242 110184920
Bradycardia 17.05 10.00 435 403702 155082 110030080
Barotrauma 16.99 10.00 10 404127 188 110184974
Venous thrombosis 16.95 10.00 5 404132 8500 110176662
Immune-mediated enterocolitis 16.92 10.00 8 404129 10177 110174985
Culture urine positive 16.89 10.00 47 404090 4749 110180413
Vaginal haemorrhage 16.87 10.00 42 404095 25032 110160130
Gastroenteritis viral 16.87 10.00 58 404079 31168 110153994
Seronegative arthritis 16.86 10.00 14 404123 13163 110171999
Dermatitis acneiform 16.86 10.00 13 404124 12682 110172480
Type 1 diabetes mellitus 16.82 10.00 6 404131 9041 110176121
Pseudomonal sepsis 16.82 10.00 6 404131 9040 110176122
Wheelchair user 16.78 10.00 4 404133 7838 110177324
Gangrene 16.77 10.00 21 404116 16320 110168842
Potentiating drug interaction 16.67 10.00 11 404126 11632 110173530
Myopathy 16.64 10.00 42 404095 24918 110160244
Cytomegalovirus chorioretinitis 16.57 10.00 3 404134 7125 110178037
Staphylococcal bacteraemia 16.56 10.00 22 404115 16666 110168496
Sinus tachycardia 16.55 10.00 95 404042 44398 110140764
Spinal compression fracture 16.52 10.00 26 404111 18366 110166796
Upper limb fracture 16.52 10.00 32 404105 20856 110164306
Herpes simplex 16.45 10.00 20 404117 15744 110169418
Cachexia 16.42 10.00 14 404123 12991 110172171
Influenza like illness 16.33 10.00 226 403911 88186 110096976
Overlap syndrome 16.28 10.00 71 404066 8988 110176174
Fear 16.28 10.00 38 404099 23155 110162007
Malignant palate neoplasm 16.23 10.00 4 404133 3 110185159
B-cell lymphoma stage II 16.23 10.00 4 404133 3 110185159
Exposure via body fluid 16.18 10.00 12 404125 337 110184825
Pneumonia fungal 16.17 10.00 18 404119 14736 110170426
Product use issue 16.14 10.00 953 403184 310742 109874420
Hyperaesthesia 16.11 10.00 18 404119 14709 110170453
Pneumonia cytomegaloviral 16.00 10.00 3 404134 6951 110178211
Cervix disorder 15.90 10.00 12 404125 346 110184816
Systemic infection 15.88 10.00 8 404129 9811 110175351
Pelvic fracture 15.81 10.00 17 404120 14137 110171025
Tendonitis 15.81 10.00 46 404091 26037 110159125
Breast disorder female 15.80 10.00 8 404129 110 110185052
Mydriasis 15.79 10.00 36 404101 22121 110163041
Bradykinesia 15.71 10.00 10 404127 10778 110174384
Hypovolaemia 15.62 10.00 35 404102 21639 110163523
Hepatic encephalopathy 15.59 10.00 52 404085 28204 110156958
Incorrect dose administered by device 15.55 10.00 3 404134 6811 110178351
Disturbance in attention 15.55 10.00 148 403989 61847 110123315
Pseudomonas infection 15.55 10.00 51 404086 27802 110157360
Malignant neoplasm of eye 15.54 10.00 8 404129 114 110185048
Endocrine ophthalmopathy 15.54 10.00 22 404115 1351 110183811
Throat tightness 15.53 10.00 189 403948 33300 110151862
Hypothermia 15.50 10.00 47 404090 26255 110158907
Grip strength 15.47 10.00 7 404130 9134 110176028
Device related infection 15.45 10.00 83 404054 39436 110145726
Dysuria 15.44 10.00 143 403994 60088 110125074
Blood pressure inadequately controlled 15.42 10.00 62 404075 7571 110177591
Hypercholesterolaemia 15.39 10.00 438 403699 90399 110094763
Needle issue 15.30 10.00 26 404111 17814 110167348
Nocturia 15.28 10.00 24 404113 16966 110168196
Mixed liver injury 15.25 10.00 13 404124 12066 110173096
Crepitations 15.17 10.00 79 404058 10756 110174406
Alcohol poisoning 15.12 10.00 7 404130 9013 110176149
Peripheral ischaemia 15.10 10.00 11 404126 11047 110174115
Syringe issue 15.05 10.00 8 404129 9517 110175645
Gingival atrophy 15.04 10.00 7 404130 79 110185083
Peritonitis bacterial 15.01 10.00 10 404127 10523 110174639
Graft versus host disease in gastrointestinal tract 14.97 10.00 7 404130 8961 110176201
Fluid retention 14.96 10.00 451 403686 93856 110091306
Organising pneumonia 14.94 10.00 18 404119 14225 110170937
Eating disorder 14.91 10.00 60 404077 30798 110154364
Eyelid ptosis 14.89 10.00 16 404121 13311 110171851
Congestive cardiomyopathy 14.88 10.00 18 404119 14201 110170961
Eosinophilic pneumonia 14.86 10.00 4 404133 7223 110177939
Hypoalbuminaemia 14.86 10.00 55 404082 28919 110156243
Atrioventricular block complete 14.83 10.00 32 404105 20050 110165112
Psychomotor retardation 14.78 10.00 5 404132 7787 110177375
Blood phosphorus increased 14.77 10.00 23 404114 16317 110168845
Dialysis 14.71 10.00 31 404106 19588 110165574
Skin ulcer 14.69 10.00 155 403982 63490 110121672
Brain herniation 14.67 10.00 7 404130 8856 110176306
Product preparation error 14.62 10.00 11 404126 10868 110174294
Basal cell carcinoma 14.60 10.00 101 404036 45169 110139993
Renal cell carcinoma stage III 14.55 10.00 5 404132 23 110185139
Cutaneous vasculitis 14.54 10.00 15 404122 12714 110172448
Alanine aminotransferase abnormal 14.51 10.00 8 404129 9326 110175836
Blood creatinine decreased 14.48 10.00 69 404068 9068 110176094
Neutrophil count decreased 14.43 10.00 334 403803 120607 110064555
Dementia 14.43 10.00 63 404074 31610 110153552
Spinal stenosis 14.38 10.00 30 404107 19026 110166136
Paraneoplastic rash 14.37 10.00 7 404130 88 110185074
Chronic spontaneous urticaria 14.37 10.00 26 404111 1967 110183195
Oral candidiasis 14.37 10.00 100 404037 44660 110140502
Peripheral arterial occlusive disease 14.36 10.00 8 404129 9272 110175890
Antinuclear antibody positive 14.36 10.00 69 404068 9099 110176063
Infusion site streaking 14.35 10.00 14 404123 576 110184586
Injection site warmth 14.35 10.00 26 404111 17379 110167783
Embolic stroke 14.32 10.00 7 404130 8736 110176426
Hypoxia 14.27 10.00 362 403775 129153 110056009
Oropharyngeal pain 14.14 10.00 381 403756 134895 110050267
Varicella zoster virus infection 14.13 10.00 3 404134 6365 110178797
Anal abscess 14.12 10.00 13 404124 11625 110173537
Eosinophilic granulomatosis with polyangiitis 14.12 10.00 11 404126 10675 110174487
Lymphocytic infiltration 14.07 10.00 26 404111 1999 110183163
Salivary gland cancer 14.07 10.00 13 404124 499 110184663
Leukopenia 14.05 10.00 425 403712 148366 110036796
Hypertensive crisis 14.04 10.00 44 404093 24328 110160834
Pulmonary tuberculosis 13.97 10.00 8 404129 9131 110176031
Ageusia 13.94 10.00 32 404105 19613 110165549
Cerebral haematoma 13.93 10.00 9 404128 9623 110175539
Paranoia 13.90 10.00 39 404098 22335 110162827
Wrong technique in device usage process 13.85 10.00 4 404133 6897 110178265
Breast cancer recurrent 13.85 10.00 38 404099 3808 110181354
Abdominal wall neoplasm malignant 13.85 10.00 3 404134 0 110185162
Chronic lymphocytic leukaemia stage 3 13.85 10.00 3 404134 0 110185162
Oropharyngeal cancer stage IV 13.85 10.00 3 404134 0 110185162
Anal cancer stage IV 13.85 10.00 3 404134 0 110185162
Head and neck cancer stage II 13.85 10.00 3 404134 0 110185162
Lip and/or oral cavity cancer stage II 13.85 10.00 3 404134 0 110185162
Bile duct cancer stage I 13.85 10.00 3 404134 0 110185162
Appendix cancer metastatic 13.85 10.00 3 404134 0 110185162
Small intestine carcinoma recurrent 13.85 10.00 3 404134 0 110185162
Hypertransaminasaemia 13.82 10.00 44 404093 24211 110160951
Device breakage 13.82 10.00 18 404119 13751 110171411
Hepatitis fulminant 13.80 10.00 7 404130 8553 110176609
Psoriatic arthropathy 13.79 10.00 583 403554 196178 109988984
Endometrial cancer stage IV 13.78 10.00 4 404133 9 110185153
Jaundice 13.78 10.00 144 403993 59092 110126070
Hereditary angioedema 13.75 10.00 57 404080 7057 110178105
Product substitution issue 13.74 10.00 41 404096 23020 110162142
Leukocytosis 13.71 10.00 128 404009 53700 110131462
Metabolic disorder 13.66 10.00 11 404126 10499 110174663
Gout 13.64 10.00 78 404059 36488 110148674
Haemorrhage intracranial 13.58 10.00 57 404080 28912 110156250
Oliguria 13.55 10.00 30 404107 18627 110166535
Electroencephalogram abnormal 13.51 10.00 3 404134 6170 110178992
Snoring 13.50 10.00 4 404133 6780 110178382
Brain abscess 13.46 10.00 4 404133 6770 110178392
Respiratory depth decreased 13.46 10.00 5 404132 30 110185132
Drug specific antibody present 13.45 10.00 7 404130 8427 110176735
Bacterial sepsis 13.44 10.00 11 404126 10415 110174747
Metastatic lymphoma 13.35 10.00 14 404123 628 110184534
Bicytopenia 13.31 10.00 4 404133 6720 110178442
Mean cell haemoglobin increased 13.30 10.00 48 404089 5569 110179593
Immune-mediated hepatitis 13.27 10.00 4 404133 6707 110178455
Diarrhoea haemorrhagic 13.22 10.00 23 404114 15616 110169546
Atrioventricular block 13.22 10.00 26 404111 16851 110168311
Bradyphrenia 13.20 10.00 14 404123 11714 110173448
Pulmonary haemorrhage 13.20 10.00 25 404112 16431 110168731
Rash papular 13.19 10.00 54 404083 27585 110157577
Genital haemorrhage 13.16 10.00 5 404132 7247 110177915
Drug monitoring procedure not performed 13.15 10.00 20 404117 1310 110183852
Angina unstable 13.14 10.00 25 404112 16407 110168755
Infusion site reaction 13.14 10.00 110 404027 17572 110167590
Left ventricular dysfunction 13.12 10.00 43 404094 23450 110161712
Skin lesion 13.06 10.00 123 404014 51508 110133654
Blindness unilateral 13.02 10.00 10 404127 9776 110175386
Vaginal cancer 13.00 10.00 9 404128 226 110184936
Pneumonia viral 12.91 10.00 13 404124 11144 110174018
Liver injury 12.91 10.00 435 403702 149978 110035184
Oral herpes 12.91 10.00 78 404059 36002 110149160
Bronchospasm 12.89 10.00 168 403969 30071 110155091
Paternal exposure timing unspecified 12.87 10.00 6 404131 68 110185094
Psychomotor hyperactivity 12.85 10.00 35 404102 20242 110164920
Muscle injury 12.85 10.00 404 403733 140403 110044759
Diabetes insipidus 12.84 10.00 4 404133 6566 110178596
Hospice care 12.83 10.00 16 404121 12457 110172705
Open angle glaucoma 12.81 10.00 13 404124 561 110184601
Pneumothorax 12.77 10.00 76 404061 35209 110149953
Metastatic gastric cancer 12.76 10.00 11 404126 385 110184777
Febrile bone marrow aplasia 12.76 10.00 28 404109 17437 110167725
Leukoencephalopathy 12.75 10.00 9 404128 9186 110175976
Chronic leukaemia 12.72 10.00 4 404133 13 110185149
Optic discs blurred 12.72 10.00 6 404131 70 110185092
Insurance issue 12.71 10.00 12 404125 10600 110174562
Contraindicated product administered 12.68 10.00 760 403377 247507 109937655
Metabolic encephalopathy 12.67 10.00 13 404124 11047 110174115
Cardiomegaly 12.64 10.00 59 404078 29071 110156091
Respiratory symptom 12.61 10.00 22 404115 14923 110170239
Metastases to central nervous system 12.58 10.00 42 404095 22775 110162387
Ketoacidosis 12.56 10.00 11 404126 10076 110175086
Tooth deposit 12.55 10.00 10 404127 313 110184849
Cytomegalovirus test positive 12.53 10.00 5 404132 7031 110178131
Dystrophic calcification 12.52 10.00 8 404129 175 110184987
Thyroid cancer metastatic 12.52 10.00 8 404129 175 110184987
Complication associated with device 12.46 10.00 35 404102 20038 110165124
Vascular device infection 12.45 10.00 26 404111 16486 110168676
Muscular weakness 12.45 10.00 762 403375 247706 109937456
Wrong product administered 12.43 10.00 13 404124 10947 110174215
Myelocyte count increased 12.41 10.00 16 404121 898 110184264
Blood potassium decreased 12.40 10.00 132 404005 53982 110131180
Coronavirus infection 12.39 10.00 10 404127 9535 110175627
Myositis 12.36 10.00 65 404072 31051 110154111
Adenoid cystic carcinoma 12.35 10.00 5 404132 39 110185123
Mite allergy 12.34 10.00 3 404134 5800 110179362
White blood cells urine 12.33 10.00 12 404125 492 110184670
Device leakage 12.33 10.00 25 404112 16023 110169139
Immunisation reaction 12.32 10.00 15 404122 794 110184368
Nephropathy toxic 12.31 10.00 55 404082 27423 110157739
Clostridium test positive 12.26 10.00 13 404124 10880 110174282
Electrolyte imbalance 12.25 10.00 82 404055 36946 110148216
Granuloma 12.25 10.00 10 404127 9480 110175682
Malignant melanoma stage III 12.24 10.00 5 404132 40 110185122
Kidney infection 12.23 10.00 50 404087 25549 110159613
Rash pruritic 12.22 10.00 269 403868 97800 110087362
Superinfection 12.21 10.00 3 404134 5760 110179402
Sleep disorder therapy 12.21 10.00 6 404131 7465 110177697
Hypothalamo-pituitary disorder 12.18 10.00 30 404107 2816 110182346
Neurosis 12.15 10.00 13 404124 597 110184565
Extravasation blood 12.15 10.00 12 404125 501 110184661
Folliculitis 12.12 10.00 495 403642 167158 110018004
Heart rate decreased 12.11 10.00 221 403916 82535 110102627
Rhinitis 12.09 10.00 42 404095 22503 110162659
Arthritis bacterial 12.08 10.00 13 404124 10807 110174355
Aplastic anaemia 12.07 10.00 139 403998 24169 110160993
Multiple fractures 12.07 10.00 9 404128 8931 110176231
Nasal neoplasm 12.06 10.00 8 404129 187 110184975
Neck pain 12.06 10.00 558 403579 122572 110062590
Hepatocellular carcinoma 12.03 10.00 11 404126 9869 110175293
Lichenoid keratosis 12.03 10.00 4 404133 6298 110178864
Neuritis 12.01 10.00 6 404131 7393 110177769
Fear of injection 11.99 10.00 9 404128 8902 110176260
Hallucination, visual 11.98 10.00 90 404047 39515 110145647
Ankle fracture 11.98 10.00 35 404102 19784 110165378
Malignant melanoma stage IV 11.97 10.00 7 404130 130 110185032
Hypertonia 11.96 10.00 8 404129 8398 110176764
Lung infiltration 11.83 10.00 48 404089 24580 110160582
Hypercapnia 11.81 10.00 14 404123 11145 110174017
Oesophageal dysplasia 11.78 10.00 3 404134 3 110185159
Metastases to prostate 11.78 10.00 3 404134 3 110185159
Large cell lung cancer stage IV 11.78 10.00 3 404134 3 110185159
Therapeutic response unexpected 11.75 10.00 46 404091 23797 110161365
Excessive eye blinking 11.75 10.00 23 404114 1847 110183315
Hepatic enzyme abnormal 11.74 10.00 11 404126 9752 110175410
Anaemia macrocytic 11.73 10.00 6 404131 7297 110177865
Polyuria 11.71 10.00 30 404107 17708 110167454
Feeling jittery 11.70 10.00 93 404044 14629 110170533
Abscess 11.70 10.00 56 404081 27413 110157749
Hyperthyroidism 11.69 10.00 61 404076 29200 110155962
Migraine 11.67 10.00 752 403385 170900 110014262
Injury 11.65 10.00 529 403608 176736 110008426
Red blood cell count increased 11.62 10.00 42 404095 4876 110180286
Blood pressure diastolic decreased 11.60 10.00 80 404057 35805 110149357
Hyperkeratosis 11.60 10.00 10 404127 9229 110175933
Upper gastrointestinal haemorrhage 11.56 10.00 122 404015 49974 110135188
Dental caries 11.53 10.00 18 404119 12755 110172407
Ventricular fibrillation 11.51 10.00 96 404041 41217 110143945
Osteopenia 11.49 10.00 42 404095 22167 110162995
Burns second degree 11.49 10.00 7 404130 7726 110177436
Orthopnoea 11.48 10.00 14 404123 11007 110174155
Porphyria acute 11.47 10.00 33 404104 18747 110166415
Wrong patient received product 11.47 10.00 5 404132 6669 110178493
Urobilinogen urine increased 11.46 10.00 13 404124 638 110184524
Blood urea increased 11.44 10.00 137 404000 54820 110130342
Squamous cell carcinoma of skin 11.43 10.00 29 404108 17174 110167988
Skin hyperpigmentation 11.43 10.00 9 404128 8687 110176475
Depression 11.42 10.00 1001 403136 316334 109868828
Intraventricular haemorrhage 11.42 10.00 3 404134 5504 110179658
Decreased immune responsiveness 11.41 10.00 67 404070 9539 110175623
Pancreatitis necrotising 11.40 10.00 3 404134 5498 110179664
Azotaemia 11.39 10.00 12 404125 10073 110175089
Obesity 11.38 10.00 515 403622 112836 110072326
Swollen joint count 11.37 10.00 9 404128 8665 110176497
Spinal operation 11.37 10.00 14 404123 10958 110174204
Movement disorder 11.36 10.00 82 404055 36322 110148840
Hepatitis B 11.36 10.00 11 404126 9601 110175561
Necrosis 11.35 10.00 15 404122 11391 110173771
Lymphopenia 11.35 10.00 93 404044 40077 110145085
Endocrine neoplasm 11.32 10.00 3 404134 4 110185158
Hypopnoea 11.29 10.00 15 404122 11365 110173797
Skin irritation 11.24 10.00 27 404110 16292 110168870
Musculoskeletal discomfort 11.23 10.00 46 404091 23492 110161670
Aortic stenosis 11.23 10.00 19 404118 13040 110172122
Vasoplegia syndrome 11.20 10.00 3 404134 5436 110179726
Abdominal pain upper 11.17 10.00 1448 402689 347663 109837499
Oral pruritus 11.17 10.00 32 404105 3288 110181874
Blood sodium decreased 11.16 10.00 88 404049 38231 110146931
Iridocyclitis 11.11 10.00 3 404134 5405 110179757
Sarcoidosis 11.09 10.00 18 404119 12561 110172601
Chronic kidney disease 11.09 10.00 361 403776 75930 110109232
Kounis syndrome 11.08 10.00 47 404090 5878 110179284
Tooth extraction 11.08 10.00 19 404118 12972 110172190
Malignant neoplasm of thymus 11.06 10.00 4 404133 22 110185140
Blood lactate dehydrogenase increased 11.05 10.00 106 404031 44228 110140934
Neutropenic colitis 11.04 10.00 8 404129 8057 110177105
Depressed mood 11.03 10.00 156 403981 60653 110124509
Endocarditis 11.00 10.00 20 404117 13351 110171811
Soft tissue sarcoma 10.99 10.00 9 404128 293 110184869
Ovarian hyperstimulation syndrome 10.96 10.00 3 404134 5357 110179805
Pain of skin 10.95 10.00 37 404100 19992 110165170
Coronary artery stenosis 10.95 10.00 21 404116 13737 110171425
Coronary artery occlusion 10.94 10.00 26 404111 15746 110169416
Anti-thyroid antibody positive 10.91 10.00 12 404125 569 110184593
Anal fissure 10.89 10.00 12 404125 9869 110175293
Iron deficiency anaemia 10.89 10.00 69 404068 31490 110153672
Colorectal cancer recurrent 10.88 10.00 6 404131 99 110185063
Liver function test increased 10.88 10.00 411 403726 88137 110097025
Rheumatic fever 10.87 10.00 353 403784 122226 110062936
Intervertebral discitis 10.85 10.00 6 404131 6984 110178178
Oropharyngeal cancer 10.84 10.00 7 404130 156 110185006
HER2 positive breast cancer 10.84 10.00 10 404127 383 110184779
Cyst 10.81 10.00 28 404109 16468 110168694
Nasal ulcer 10.79 10.00 27 404110 2560 110182602
Infusion site thrombosis 10.68 10.00 9 404128 305 110184857
Pharyngeal disorder 10.68 10.00 28 404109 2731 110182431
Renal tubular disorder 10.66 10.00 7 404130 7422 110177740
Vasodilatation 10.63 10.00 34 404103 3710 110181452
Hypoacusis 10.63 10.00 80 404057 35111 110150051
Wound secretion 10.60 10.00 6 404131 6895 110178267
Intestinal obstruction 10.58 10.00 134 404003 53093 110132069
Device occlusion 10.56 10.00 25 404112 15160 110170002
Colorectal cancer metastatic 10.54 10.00 20 404117 1569 110183593
Neoplasm of thymus 10.50 10.00 4 404133 26 110185136
Escherichia bacteraemia 10.50 10.00 13 404124 10151 110175011
Carotid artery stenosis 10.49 10.00 11 404126 9252 110175910
Hidradenitis 10.40 10.00 3 404134 5177 110179985
Hypocalcaemia 10.39 10.00 172 403965 65194 110119968
SARS-CoV-2 test false positive 10.37 10.00 4 404133 27 110185135
Aortic valve incompetence 10.37 10.00 15 404122 10966 110174196
Liposarcoma 10.34 10.00 9 404128 319 110184843
Gastroenteritis bacterial 10.34 10.00 11 404126 502 110184660
Intracranial pressure increased 10.34 10.00 14 404123 10521 110174641
Joint noise 10.29 10.00 3 404134 5140 110180022
Analgesic therapy 10.27 10.00 7 404130 7277 110177885
Rectal cancer stage I 10.26 10.00 3 404134 7 110185155
Thyroid stimulating immunoglobulin increased 10.25 10.00 7 404130 172 110184990
Post procedural infection 10.20 10.00 22 404115 13787 110171375
Cardiac dysfunction 10.17 10.00 5 404132 6218 110178944
Acidosis 10.15 10.00 45 404092 22486 110162676
Face oedema 10.15 10.00 76 404061 33393 110151769
Glomerular filtration rate decreased 10.15 10.00 63 404074 28893 110156269
Inflammatory bowel disease 10.14 10.00 7 404130 7227 110177935
Meningioma 10.13 10.00 4 404133 5661 110179501
Withdrawal syndrome 10.13 10.00 70 404067 31310 110153852
Speech disorder 10.12 10.00 161 403976 61408 110123754
Diplopia 10.09 10.00 101 404036 41793 110143369
Antineutrophil cytoplasmic antibody positive 10.08 10.00 3 404134 5073 110180089
Meningitis 10.08 10.00 17 404120 11685 110173477
Streptococcal sepsis 10.07 10.00 3 404134 5069 110180093
Herpes virus infection 10.07 10.00 10 404127 8628 110176534
Monoclonal immunoglobulin present 10.06 10.00 26 404111 2514 110182648
Blood glucose abnormal 10.03 10.00 20 404117 12896 110172266
Secretion discharge 10.01 10.00 39 404098 20205 110164957
Injection site mass 10.01 10.00 51 404086 24562 110160600

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists
FDA MoA N0000000151 Histamine H2 Receptor Antagonists
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006635 Histamine H2 Antagonists
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175784 Histamine-2 Receptor Antagonist
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37961 H<small><sub>2</sub></small>-receptor antagonist
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen

Related Drugs by ATC class:

A02BA H2-receptor antagonists 6 drugs
cimetidinefamotidinelafutidineniperotidinenizatidineroxatidine acetate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Heartburn indication 16331000
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
Duodenal Ulcer due to H. Pylori indication
Gastric Hypersecretory Conditions indication
Maintenance of Healing Gastric Ulcer indication
Upper gastrointestinal hemorrhage off-label use 37372002
Prevention of NSAID-Induced Gastric Ulcer off-label use
Fatty Stool as Cystic Fibrosis Intestinal Manifestation off-label use
Prevention of Stress Ulcer off-label use
NSAID-Induced Gastric Ulcer off-label use
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Malignant tumor of stomach contraindication 363349007 DOID:10534
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic
pKa2 6.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H2 receptor GPCR ANTAGONIST Kd 6.86 WOMBAT-PK CHEMBL
Acetylcholinesterase Enzyme IC50 6.19 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.55 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.08 CHEMBL
Histamine H2 receptor GPCR Kd 7.19 CHEMBL
Histamine H2 receptor GPCR ANTAGONIST Ki 6.20 IUPHAR

External reference:

IDSource
D00422 KEGG_DRUG
66357-59-3 SECONDARY_CAS_RN
4018896 VANDF
4019927 VANDF
CHEBI:8776 CHEBI
CHEMBL1790041 ChEMBL_ID
CHEMBL2110372 ChEMBL_ID
1234 IUPHAR_LIGAND_ID
DB00863 DRUGBANK_ID
152523 RXNORM
1431 MMSL
5413 MMSL
911 MMSL
d00021 MMSL
003416 NDDF
004444 NDDF
24202000 SNOMEDCT_US
372755005 SNOMEDCT_US
48174005 SNOMEDCT_US
C0034665 UMLSCUI
D011899 MESH_DESCRIPTOR_UI
4660 INN_ID
3001055 PUBCHEM_CID
884KT10YB7 UNII
884KT10YB7 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0727 SYRUP 15 mg ORAL ANDA 23 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4727 SYRUP 15 mg ORAL ANDA 23 sections
Ranitidine HUMAN OTC DRUG LABEL 1 0363-0352 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
Wal-Zan HUMAN OTC DRUG LABEL 1 0363-0362 TABLET 150 mg ORAL ANDA 14 sections
Ranitidine HUMAN OTC DRUG LABEL 1 0440-2300 TABLET, FILM COATED 150 mg ORAL ANDA 14 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0440-8300 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0440-8305 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2855 CAPSULE 150 mg ORAL ANDA 24 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2865 CAPSULE 300 mg ORAL ANDA 24 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-056 TABLET 150 mg ORAL ANDA 11 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-438 TABLET, FILM COATED 150 mg ORAL ANDA 24 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-516 TABLET 150 mg ORAL ANDA 11 sections
Acid Reducer HUMAN OTC DRUG LABEL 1 15127-340 TABLET 150 mg ORAL ANDA 14 sections
Ranitidine Hydrochloride HUMAN OTC DRUG LABEL 1 15127-711 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
RANITIDINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-200 TABLET 150 mg ORAL ANDA 10 sections
RANITIDINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-381 TABLET 300 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 17856-0664 SOLUTION 15 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 17856-0727 SOLUTION 15 mg ORAL ANDA 24 sections
Acid Reducer HUMAN OTC DRUG LABEL 1 21130-003 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 21695-109 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 21695-110 TABLET 300 mg ORAL ANDA 10 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-337 CAPSULE 150 mg ORAL ANDA 24 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-338 CAPSULE 300 mg ORAL ANDA 24 sections
Ranitidine Human Prescription Drug Label 1 27241-109 CAPSULE 150 mg ORAL ANDA 19 sections
Ranitidine Human Prescription Drug Label 1 27241-110 CAPSULE 300 mg ORAL ANDA 19 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 33261-099 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 33261-202 TABLET 300 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 33358-316 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN OTC DRUG LABEL 1 37012-351 TABLET 150 mg ORAL ANDA 14 sections
Acid Reducer HUMAN OTC DRUG LABEL 1 37808-351 TABLET 150 mg ORAL ANDA 14 sections