ranitidine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 2358 66357-35-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zantac
  • zenetac
  • ranitidine hydrochloride
  • ranitidine HCl
  • ranitidine
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
  • Molecular weight: 314.40
  • Formula: C13H22N4O3S
  • CLOGP: 0.67
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 83.58
  • ALOGS: -3.60
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 28.50 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
S (Water solubility) 660 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 69 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.95 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 29, 1977 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Breast cancer stage I 26433.33 9.92 5819 207940 1070 63274193
Breast cancer female 25600.36 9.92 6445 207314 7114 63268149
Breast cancer stage II 19795.06 9.92 4811 208948 3925 63271338
Colorectal cancer 11719.34 9.92 2668 211091 977 63274286
Breast cancer stage III 9235.81 9.92 2734 211025 7652 63267611
Renal cancer 8210.72 9.92 2178 211581 3384 63271879
Bladder cancer 7871.99 9.92 2107 211652 3459 63271804
Breast cancer stage IV 7215.30 9.92 1607 212152 379 63274884
Oesophageal carcinoma 7057.95 9.92 1645 212114 839 63274424
Colorectal cancer stage III 6660.52 9.92 1417 212342 0 63275263
Colorectal cancer stage IV 6314.66 9.92 1346 212413 12 63275251
Hepatic cancer stage IV 4867.47 9.92 1037 212722 6 63275257
Gastric cancer 4723.89 9.92 1363 212396 3360 63271903
Pancreatic carcinoma stage IV 4530.53 9.92 974 212785 48 63275215
Colorectal cancer stage II 3890.83 9.92 828 212931 0 63275263
Hepatic cancer 3789.69 9.92 1136 212623 3351 63271912
Uterine cancer 3665.90 9.92 1121 212638 3612 63271651
Pancreatic carcinoma 3068.90 9.92 1102 212657 6526 63268737
Colorectal cancer stage I 2941.32 9.92 626 213133 0 63275263
Renal cancer stage I 2858.44 9.92 609 213150 3 63275260
Lung carcinoma cell type unspecified stage IV 2709.13 9.92 671 213088 633 63274630
Gastric cancer stage IV 2639.88 9.92 577 213182 76 63275187
Renal cancer stage IV 2416.92 9.92 522 213237 37 63275226
Gastrointestinal carcinoma 2095.92 9.92 608 213151 1535 63273728
Thyroid cancer 2020.12 9.92 747 213012 4864 63270399
Renal cancer stage II 1968.51 9.92 419 213340 0 63275263
Lung neoplasm malignant 1779.27 9.92 998 212761 18635 63256628
Renal cancer stage III 1714.77 9.92 365 213394 0 63275263
Gastric cancer stage I 1714.77 9.92 365 213394 0 63275263
Bladder cancer stage IV 1531.52 9.92 326 213433 0 63275263
Bladder cancer stage II 1273.10 9.92 271 213488 0 63275263
Lung carcinoma cell type unspecified stage I 1141.04 9.92 255 213504 64 63275199
Gastric cancer stage II 1136.84 9.92 242 213517 0 63275263
Pancreatic carcinoma stage III 1122.75 9.92 239 213520 0 63275263
Brain neoplasm malignant 1002.47 9.92 300 213459 876 63274387
Gastric cancer stage III 995.90 9.92 212 213547 0 63275263
Pancreatic carcinoma stage II 972.41 9.92 207 213552 0 63275263
Haematological malignancy 927.85 9.92 230 213529 218 63275045
Thyroid cancer stage I 897.24 9.92 191 213568 0 63275263
Bladder cancer stage III 887.84 9.92 189 213570 0 63275263
Lung carcinoma cell type unspecified stage III 836.74 9.92 192 213567 78 63275185
Ovarian cancer 831.34 9.92 405 213354 5571 63269692
Skin cancer 777.84 9.92 484 213275 11011 63264252
Pancreatic carcinoma stage I 758.04 9.92 162 213597 3 63275260
Disease progression 728.54 9.92 1404 212355 121354 63153909
Drug ineffective 669.06 9.92 1596 212163 1043169 62232094
Lung carcinoma cell type unspecified stage II 624.67 9.92 143 213616 56 63275207
Neoplasm malignant 616.36 9.92 624 213135 29237 63246026
Ovarian cancer stage IV 585.66 9.92 145 213614 136 63275127
Pemphigus 572.38 9.92 9 213750 183717 63091546
Hepatic cancer stage III 558.99 9.92 119 213640 0 63275263
Hepatic cancer stage II 554.30 9.92 118 213641 0 63275263
Ovarian cancer stage I 549.60 9.92 117 213642 0 63275263
Hepatic cancer stage I 540.20 9.92 115 213644 0 63275263
Breast cancer 525.59 9.92 728 213031 47655 63227608
Systemic lupus erythematosus 506.67 9.92 56 213703 208862 63066401
Synovitis 482.68 9.92 39 213720 186879 63088384
Thyroid cancer stage II 450.95 9.92 96 213663 0 63275263
Cervix carcinoma 428.96 9.92 208 213551 2829 63272434
Appendix cancer 424.43 9.92 97 213662 37 63275226
Glossodynia 421.15 9.92 53 213706 178823 63096440
Arthropathy 405.71 9.92 142 213617 234650 63040613
Bone cancer 376.37 9.92 152 213607 1290 63273973
Throat cancer 372.55 9.92 121 213638 498 63274765
Pericarditis 361.47 9.92 20 213739 131559 63143704
Alopecia 354.88 9.92 368 213391 337168 62938095
Hand deformity 350.34 9.92 58 213701 159399 63115864
Ovarian cancer stage III 345.85 9.92 97 213662 206 63275057
Wound 344.33 9.92 66 213693 163197 63112066
Small intestine carcinoma 343.93 9.92 107 213652 370 63274893
Anti-cyclic citrullinated peptide antibody positive 330.98 9.92 14 213745 116198 63159065
Ovarian cancer stage II 305.43 9.92 67 213692 10 63275253
Thyroid cancer stage IV 295.93 9.92 63 213696 0 63275263
Toxicity to various agents 293.54 9.92 241 213518 247009 63028254
Joint swelling 291.50 9.92 407 213352 327259 62948004
Treatment failure 287.38 9.92 156 213603 198887 63076376
Thyroid cancer stage III 277.14 9.92 59 213700 0 63275263
Completed suicide 275.03 9.92 75 213684 145598 63129665
Small intestine carcinoma stage IV 267.75 9.92 57 213702 0 63275263
Swelling 260.22 9.92 327 213432 275051 63000212
Rheumatoid factor positive 255.22 9.92 6 213753 84400 63190863
Thyroid cancer stage 0 253.65 9.92 54 213705 0 63275263
Cervix carcinoma stage I 249.20 9.92 55 213704 10 63275253
Food allergy 245.76 9.92 244 213515 11157 63264106
Maternal exposure during pregnancy 240.14 9.92 232 213527 219830 63055433
Helicobacter infection 234.90 9.92 21 213738 92764 63182499
Contraindicated product administered 233.40 9.92 233 213526 217415 63057848
Duodenal ulcer perforation 231.25 9.92 16 213743 87193 63188070
Abdominal discomfort 220.89 9.92 469 213290 320416 62954847
Discomfort 215.39 9.92 150 213609 167224 63108039
Drug intolerance 212.56 9.92 451 213308 308210 62967053
Temperature regulation disorder 211.22 9.92 171 213588 5961 63269302
Off label use 208.40 9.92 1374 212385 673088 62602175
Gastric cancer stage 0 197.28 9.92 42 213717 0 63275263
Death 195.89 9.92 628 213131 373753 62901510
Cervix carcinoma stage II 192.88 9.92 45 213714 23 63275240
Prostate cancer 192.59 9.92 41 213718 0 63275263
Cervix carcinoma stage IV 186.74 9.92 45 213714 33 63275230
Folliculitis 183.27 9.92 14 213745 70303 63204960
Urinary sediment present 180.71 9.92 105 213654 2098 63273165
Condition aggravated 179.68 9.92 721 213038 401496 62873767
Therapeutic product effect decreased 179.68 9.92 232 213527 192955 63082308
Muscle injury 179.20 9.92 10 213749 65335 63209928
Colon cancer stage IV 178.60 9.92 54 213705 165 63275098
Schizoaffective disorder 177.68 9.92 124 213635 3438 63271825
Erythema 173.73 9.92 1099 212660 174652 63100611
Gallbladder cancer 172.63 9.92 60 213699 317 63274946
Gallbladder cancer stage IV 169.10 9.92 36 213723 0 63275263
Infection 166.06 9.92 325 213434 228848 63046415
Urine abnormality 165.87 9.92 158 213601 6861 63268402
Therapeutic product effect incomplete 164.97 9.92 109 213650 124947 63150316
Crystal urine present 163.25 9.92 89 213670 1565 63273698
Colon cancer stage III 154.85 9.92 44 213715 100 63275163
Colon cancer 153.90 9.92 178 213581 9700 63265563
Fall 152.36 9.92 741 213018 391593 62883670
Lymphocyte count decreased 151.71 9.92 323 213436 29934 63245329
Pain 151.67 9.92 1680 212079 738948 62536315
Colorectal carcinoma stage 0 150.31 9.92 32 213727 0 63275263
Cervix carcinoma stage III 147.38 9.92 36 213723 30 63275233
Infusion related reaction 146.38 9.92 387 213372 245134 63030129
Drug abuse 145.22 9.92 33 213726 72485 63202778
Lymphoma 140.76 9.92 189 213570 11998 63263265
Impaired healing 138.49 9.92 87 213672 102455 63172808
Psoriatic arthropathy 134.53 9.92 70 213689 91450 63183813
Bladder cancer stage I, with cancer in situ 131.52 9.92 28 213731 0 63275263
General physical health deterioration 131.34 9.92 303 213456 201099 63074164
Rheumatic fever 130.56 9.92 3 213756 43108 63232155
Mobility decreased 127.17 9.92 132 213627 121027 63154236
Loss of personal independence in daily activities 126.69 9.92 86 213673 97204 63178059
Red blood cells urine positive 124.56 9.92 95 213664 3031 63272232
Irritable bowel syndrome 124.18 9.92 61 213698 82351 63192912
Urine leukocyte esterase positive 123.68 9.92 100 213659 3479 63271784
Intentional product use issue 123.66 9.92 149 213610 127743 63147520
White blood cells urine positive 121.68 9.92 116 213643 5042 63270221
Urine analysis abnormal 118.70 9.92 113 213646 4903 63270360
Liver injury 118.29 9.92 29 213730 60491 63214772
Colon cancer stage I 117.17 9.92 31 213728 47 63275216
Flushing 116.81 9.92 532 213227 74555 63200708
Immunodeficiency 116.66 9.92 229 213530 20025 63255238
Toothache 115.38 9.92 221 213538 18978 63256285
Lymphocyte percentage decreased 113.00 9.92 88 213671 2897 63272366
C-reactive protein abnormal 112.53 9.92 12 213747 46084 63229179
Coeliac disease 112.01 9.92 174 213585 12623 63262640
Neutrophil percentage increased 111.93 9.92 87 213672 2856 63272407
Colon cancer stage II 110.79 9.92 31 213728 65 63275198
Stomatitis 107.26 9.92 189 213570 138536 63136727
Hepatic enzyme increased 106.61 9.92 338 213421 201990 63073273
Arthralgia 106.42 9.92 1318 212441 568392 62706871
Lung carcinoma cell type unspecified stage 0 105.23 9.92 23 213736 3 63275260
Rheumatoid arthritis 103.92 9.92 470 213289 253349 63021914
Product use in unapproved indication 103.87 9.92 286 213473 178794 63096469
Hip arthroplasty 103.09 9.92 18 213741 47628 63227635
Blister 102.97 9.92 174 213585 129640 63145623
Anaphylactic reaction 101.82 9.92 467 213292 65633 63209630
Adverse event 101.79 9.92 50 213709 67509 63207754
Weight increased 100.84 9.92 493 213266 260299 63014964
Intentional overdose 99.99 9.92 63 213696 74089 63201174
Sinusitis 98.69 9.92 410 213349 226243 63049020
Knee arthroplasty 98.39 9.92 30 213729 54176 63221087
Gastrooesophageal reflux disease 96.23 9.92 601 213158 95038 63180225
Small intestine carcinoma stage II 93.94 9.92 20 213739 0 63275263
Brain cancer metastatic 93.63 9.92 30 213729 117 63275146
Confusional state 90.13 9.92 449 213310 235931 63039332
Chronic kidney disease 88.80 9.92 345 213414 45053 63230210
Red blood cell sedimentation rate increased 88.08 9.92 20 213739 43962 63231301
Musculoskeletal stiffness 87.35 9.92 323 213436 184295 63090968
Rash 86.32 9.92 1349 212410 559522 62715741
Product use issue 86.31 9.92 415 213344 220105 63055158
Injection site pain 85.61 9.92 194 213565 129606 63145657
Pancreatic carcinoma stage 0 84.55 9.92 18 213741 0 63275263
Anaemia 83.67 9.92 611 213148 292819 62982444
Anhedonia 83.47 9.92 140 213619 10834 63264429
Pneumonia 81.72 9.92 1066 212693 455701 62819562
Nasal cavity cancer 75.72 9.92 20 213739 30 63275233
Small intestine carcinoma stage III 75.16 9.92 16 213743 0 63275263
Small intestine carcinoma stage I 75.16 9.92 16 213743 0 63275263
Therapy non-responder 74.87 9.92 87 213672 75814 63199449
Blood urine present 74.53 9.92 160 213599 14909 63260354
Fatigue 74.44 9.92 2352 211407 885676 62389587
Nasopharyngitis 73.64 9.92 527 213232 253730 63021533
Rash erythematous 73.55 9.92 311 213448 42199 63233064
Intraductal proliferative breast lesion 70.93 9.92 67 213692 2878 63272385
Gallbladder cancer stage II 70.46 9.92 15 213744 0 63275263
Haemoglobin urine present 69.56 9.92 40 213719 783 63274480
Leukaemia 69.23 9.92 78 213681 4130 63271133
Computerised tomogram thorax abnormal 68.97 9.92 53 213706 1710 63273553
Bacterial test 68.41 9.92 45 213714 1129 63274134
Overdose 66.53 9.92 184 213575 114894 63160369
Adverse drug reaction 65.85 9.92 104 213655 79610 63195653
Arthritis 65.80 9.92 187 213572 115734 63159529
Blood cholesterol increased 65.76 9.92 136 213623 93896 63181367
Tenosynovitis stenosans 65.22 9.92 68 213691 3296 63271967
Device expulsion 63.97 9.92 19 213740 34903 63240360
Peripheral swelling 63.77 9.92 580 213179 265362 63009901
Therapeutic response decreased 63.45 9.92 68 213691 61457 63213806
Blepharospasm 63.24 9.92 89 213670 5907 63269356
Pancytopenia 63.00 9.92 146 213613 96787 63178476
Product dose omission issue 62.46 9.92 497 213262 233816 63041447
Bacterial test positive 62.35 9.92 83 213676 5224 63270039
Synovial fluid analysis 61.77 9.92 57 213702 2376 63272887
Suicide attempt 60.98 9.92 69 213690 60849 63214414
Type 2 diabetes mellitus 60.04 9.92 76 213683 63792 63211471
Drug resistance 58.54 9.92 5 213754 22928 63252335
Ill-defined disorder 58.22 9.92 117 213642 81638 63193625
Computerised tomogram thorax 58.18 9.92 29 213730 420 63274843
Bursitis 57.99 9.92 263 213496 36778 63238485
Gastrointestinal disorder 57.95 9.92 236 213523 131003 63144260
Gamma-glutamyltransferase decreased 57.85 9.92 26 213733 294 63274969
Cervix carcinoma stage 0 57.79 9.92 27 213732 336 63274927
Myocardial infarction 57.53 9.92 160 213599 99733 63175530
Incorrect dose administered 57.30 9.92 372 213387 59596 63215667
Injection site reaction 56.74 9.92 68 213691 58456 63216807
Lactic acidosis 56.67 9.92 29 213730 38258 63237005
Atelectasis 56.47 9.92 180 213579 21303 63253960
COVID-19 56.05 9.92 194 213565 112909 63162354
Septic shock 55.92 9.92 86 213673 66543 63208720
Pharyngitis 55.92 9.92 172 213587 19971 63255292
Malignant neoplasm progression 55.55 9.92 121 213638 82000 63193263
Feeling hot 54.79 9.92 323 213436 50031 63225232
Infusion site coldness 53.74 9.92 22 213737 194 63275069
Oedema 52.84 9.92 161 213598 97461 63177802
Monocyte percentage increased 52.72 9.92 38 213721 1110 63274153
Osteoporosis 52.07 9.92 70 213689 57268 63217995
Renal impairment 52.02 9.92 140 213619 88215 63187048
Anal cancer stage II 51.67 9.92 11 213748 0 63275263
Tongue carcinoma stage IV 51.67 9.92 11 213748 0 63275263
Anal cancer stage III 51.67 9.92 11 213748 0 63275263
Oesophageal carcinoma stage 0 51.67 9.92 11 213748 0 63275263
Depressed level of consciousness 51.27 9.92 81 213678 61997 63213266
Multiple organ dysfunction syndrome 50.82 9.92 70 213689 56682 63218581
Sleep disorder 50.51 9.92 126 213633 81440 63193823
Drug eruption 50.09 9.92 17 213742 28677 63246586
Abortion spontaneous 49.97 9.92 51 213708 47144 63228119
Hepatic cancer metastatic 49.74 9.92 25 213734 369 63274894
Macular degeneration 48.98 9.92 11 213748 24365 63250898
Mean cell haemoglobin decreased 48.97 9.92 73 213686 5106 63270157
Therapy interrupted 48.91 9.92 24 213735 32431 63242832
Loss of employment 48.31 9.92 48 213711 2196 63273067
Osteoarthritis 48.28 9.92 162 213597 95181 63180082
Gallbladder cancer stage I 46.97 9.92 10 213749 0 63275263
Prostate cancer stage IV 46.97 9.92 10 213749 0 63275263
Chest discomfort 46.71 9.92 571 213188 109398 63165865
Drug reaction with eosinophilia and systemic symptoms 46.65 9.92 28 213731 33808 63241455
Urticaria 46.60 9.92 801 212958 165001 63110262
Acute kidney injury 46.18 9.92 617 213142 262798 63012465
Brain stem glioma 45.88 9.92 19 213740 173 63275090
Urine ketone body present 45.69 9.92 49 213710 2454 63272809
Scleritis 45.62 9.92 65 213694 4363 63270900
Mastocytosis 45.61 9.92 27 213732 559 63274704
Delirium 45.60 9.92 62 213697 50479 63224784
Hereditary angioedema 45.37 9.92 87 213672 7475 63267788
Bone erosion 44.85 9.92 4 213755 17713 63257550
Diarrhoea 44.28 9.92 1964 211795 713402 62561861
Deep vein thrombosis 44.08 9.92 140 213619 83660 63191603
Nitrite urine present 43.81 9.92 33 213726 1033 63274230
Tongue neoplasm malignant stage unspecified 43.55 9.92 30 213729 814 63274449
Accidental exposure to product 43.26 9.92 19 213740 27386 63247877
Pneumonia aspiration 43.18 9.92 230 213529 34310 63240953
Osteonecrosis of jaw 43.15 9.92 33 213726 35090 63240173
Prostate cancer stage I 42.27 9.92 9 213750 0 63275263
Gallbladder cancer stage III 42.27 9.92 9 213750 0 63275263
Laryngeal cancer stage I 42.27 9.92 9 213750 0 63275263
Cerebrovascular accident 41.81 9.92 204 213555 107820 63167443
Injection site erythema 41.65 9.92 142 213617 83032 63192231
Urethral cancer 41.12 9.92 10 213749 8 63275255
Endometrial cancer stage I 39.87 9.92 19 213740 248 63275015
Wrong technique in product usage process 39.61 9.92 95 213664 62245 63213018
Cushingoid 39.58 9.92 88 213671 8397 63266866
Allergy to chemicals 39.52 9.92 50 213709 2992 63272271
Drug tolerance decreased 39.14 9.92 6 213753 17467 63257796
Exposure during pregnancy 39.11 9.92 335 213424 155212 63120051
Hyperkalaemia 39.08 9.92 77 213682 54126 63221137
Adrenal gland cancer 38.49 9.92 13 213746 62 63275201
Cardiac failure congestive 38.46 9.92 170 213589 92263 63183000
Pyrexia 38.26 9.92 1250 212509 469228 62806035
Bone cancer metastatic 37.95 9.92 16 213743 153 63275110
Chronic obstructive pulmonary disease 37.90 9.92 98 213661 62588 63212675
Thrombocytopenia 37.80 9.92 326 213433 150831 63124432
Perfume sensitivity 37.78 9.92 27 213732 778 63274485
Thyroxine free increased 37.74 9.92 28 213731 856 63274407
Hepatic cytolysis 37.63 9.92 4 213755 15403 63259860
Small intestine carcinoma stage 0 37.58 9.92 8 213751 0 63275263
Intentional self-injury 37.21 9.92 20 213739 25667 63249596
Disability 37.16 9.92 141 213618 18206 63257057
Pleuritic pain 37.15 9.92 83 213676 7946 63267317
Femur fracture 36.89 9.92 52 213707 41704 63233559
Hepatitis 36.71 9.92 48 213711 39740 63235523
Myelosuppression 36.53 9.92 17 213742 23686 63251577
Upper respiratory tract infection 36.13 9.92 429 213330 81618 63193645
Decreased appetite 36.09 9.92 611 213148 250441 63024822
Vulval cancer 36.03 9.92 26 213733 761 63274502
Urinary tract infection 35.87 9.92 651 213108 264033 63011230
Cardiac failure 35.86 9.92 166 213593 88976 63186287
Rhabdomyolysis 35.67 9.92 58 213701 43893 63231370
Oropharyngeal oedema 35.06 9.92 19 213740 330 63274933
Sciatica 34.21 9.92 39 213720 34285 63240978
Atrial fibrillation 34.09 9.92 241 213518 116395 63158868
Specific gravity urine decreased 33.90 9.92 25 213734 757 63274506
C-reactive protein increased 33.74 9.92 184 213575 94523 63180740
Drug-induced liver injury 33.67 9.92 52 213707 40170 63235093
Sedation 33.62 9.92 49 213710 38760 63236503
Hypotension 33.12 9.92 683 213076 271921 63003342
Tongue carcinoma stage II 32.88 9.92 7 213752 0 63275263
Bile duct cancer stage IV 32.88 9.92 7 213752 0 63275263
Serotonin syndrome 32.69 9.92 29 213730 28653 63246610
Urinary casts 32.43 9.92 24 213735 731 63274532
Sense of oppression 32.20 9.92 27 213732 989 63274274
Haemorrhage 32.05 9.92 102 213657 60920 63214343
Sepsis 32.03 9.92 345 213414 152778 63122485
Respiratory failure 31.99 9.92 206 213553 101652 63173611
Breast cancer in situ 31.99 9.92 32 213727 1476 63273787
Breast disorder 31.95 9.92 41 213718 2489 63272774
Crepitations 31.62 9.92 78 213681 7962 63267301
Gastrointestinal haemorrhage 31.58 9.92 153 213606 81023 63194240
Hypoglycaemia 31.13 9.92 101 213658 59964 63215299
Cells in urine 31.13 9.92 15 213744 201 63275062
Lip and/or oral cavity cancer 30.84 9.92 25 213734 873 63274390
Posterior reversible encephalopathy syndrome 30.76 9.92 10 213749 17335 63257928
Asthenia 30.72 9.92 1021 212738 382583 62892680
Prescribed underdose 30.40 9.92 33 213726 29656 63245607
Blood thyroid stimulating hormone decreased 30.28 9.92 55 213704 4535 63270728
Drug interaction 30.27 9.92 566 213193 228565 63046698
Tonsil cancer 30.17 9.92 15 213744 216 63275047
Disease recurrence 30.00 9.92 30 213729 28000 63247263
Nasopharyngeal cancer 29.89 9.92 9 213750 27 63275236
Synovial cyst 29.81 9.92 90 213669 10343 63264920
Premature labour 29.49 9.92 101 213658 12403 63262860
Culture urine positive 29.33 9.92 48 213711 3639 63271624
Inflammation 29.22 9.92 160 213599 82113 63193150
Pulmonary fibrosis 29.17 9.92 56 213703 39753 63235510
Gait disturbance 28.92 9.92 438 213321 182740 63092523
Drug level increased 28.83 9.92 152 213607 22584 63252679
Oedema peripheral 28.28 9.92 458 213301 189053 63086210
Sedation complication 28.25 9.92 6 213753 13816 63261447
Anal cancer stage I 28.18 9.92 6 213753 0 63275263
Nasopharyngeal cancer stage IV 28.18 9.92 6 213753 0 63275263
Prostate cancer stage II 28.18 9.92 6 213753 0 63275263
Gallbladder cancer stage 0 28.18 9.92 6 213753 0 63275263
Panniculitis 27.69 9.92 3 213756 11382 63263881
Tri-iodothyronine free increased 27.53 9.92 14 213745 212 63275051
Neuroleptic malignant syndrome 27.33 9.92 4 213755 12052 63263211
Agitation 27.29 9.92 106 213653 59651 63215612
Pulmonary embolism 27.27 9.92 256 213503 116428 63158835
Drug hypersensitivity 27.26 9.92 817 212942 309870 62965393
Cestode infection 27.10 9.92 15 213744 272 63274991
Altered state of consciousness 27.01 9.92 27 213732 25203 63250060
Encephalopathy 26.87 9.92 56 213703 38564 63236699
Malignant peritoneal neoplasm 26.84 9.92 21 213738 696 63274567
Hyperhidrosis 26.77 9.92 511 213248 107325 63167938
Throat tightness 26.66 9.92 159 213600 24728 63250535
Cardio-respiratory arrest 26.34 9.92 108 213651 59851 63215412
Endometrial cancer stage II 26.31 9.92 7 213752 11 63275252
Gastrointestinal stromal tumour 26.27 9.92 25 213734 1084 63274179
Diabetes mellitus 26.13 9.92 98 213661 55712 63219551
Neutropenia 26.09 9.92 423 213336 174582 63100681
Infective pulmonary exacerbation of cystic fibrosis 26.08 9.92 77 213682 8740 63266523
Metabolic acidosis 26.08 9.92 72 213687 44997 63230266
Food intolerance 26.06 9.92 43 213716 3282 63271981
Fracture 25.90 9.92 17 213742 19567 63255696
Device dislocation 25.85 9.92 29 213730 25676 63249587
Lower limb fracture 25.84 9.92 26 213733 24195 63251068
Herpes zoster 25.78 9.92 167 213592 82295 63192968
Injury 25.71 9.92 143 213616 73104 63202159
Urine leukocyte esterase 25.64 9.92 12 213747 150 63275113
Lip pruritus 25.64 9.92 23 213736 924 63274339
Antinuclear antibody 25.51 9.92 18 213741 508 63274755
Spinal cord neoplasm 25.37 9.92 15 213744 310 63274953
Intentional product misuse 25.36 9.92 112 213647 60805 63214458
Carcinoid tumour 25.28 9.92 16 213743 375 63274888
Thyroxine free decreased 25.18 9.92 20 213739 678 63274585
Lupus-like syndrome 25.11 9.92 10 213749 15285 63259978
Renal failure 25.04 9.92 264 213495 117388 63157875
Pain in extremity 24.74 9.92 890 212869 330596 62944667
Reflux gastritis 24.69 9.92 25 213734 1170 63274093
Cholestasis 24.68 9.92 38 213721 29396 63245867
Full blood count abnormal 24.68 9.92 43 213716 31674 63243589
Creatinine renal clearance decreased 24.66 9.92 12 213747 16296 63258967
Bronchopulmonary aspergillosis allergic 24.53 9.92 34 213725 2224 63273039
Vasodilatation 24.45 9.92 35 213724 2360 63272903
Taste disorder 24.44 9.92 101 213658 13561 63261702
Pregnancy 24.31 9.92 55 213704 36781 63238482
Mast cell activation syndrome 24.26 9.92 21 213738 804 63274459
Neuroendocrine carcinoma 24.23 9.92 13 213746 221 63275042
Poisoning 24.11 9.92 8 213751 13692 63261571
Pericardial effusion 24.08 9.92 40 213719 30018 63245245
Blood glucose increased 24.01 9.92 174 213585 83582 63191681
Acute myeloid leukaemia 23.90 9.92 14 213745 17133 63258130
Orthostatic hypotension 23.86 9.92 54 213705 36106 63239157
Hyponatraemia 23.85 9.92 251 213508 111649 63163614
Endocrine ophthalmopathy 23.72 9.92 19 213740 652 63274611
Fluid retention 23.66 9.92 306 213453 59380 63215883
Band neutrophil percentage increased 23.52 9.92 13 213746 235 63275028
Tongue carcinoma stage III 23.49 9.92 5 213754 0 63275263
Tongue carcinoma stage I 23.49 9.92 5 213754 0 63275263
Sopor 23.40 9.92 24 213735 22140 63253123
Device difficult to use 23.37 9.92 7 213752 12789 63262474
Dehydration 23.27 9.92 427 213332 172927 63102336
Mean cell haemoglobin concentration increased 23.08 9.92 17 213742 514 63274749
Hospitalisation 22.85 9.92 180 213579 84901 63190362
Blood parathyroid hormone decreased 22.78 9.92 3 213756 9788 63265475
Endometrial cancer stage III 22.72 9.92 6 213753 9 63275254
Premature delivery 22.71 9.92 42 213717 30239 63245024
Anal cancer 22.71 9.92 17 213742 527 63274736
Joint stiffness 22.68 9.92 69 213690 41800 63233463
Lip dry 22.47 9.92 12 213747 15458 63259805
Infusion site induration 22.44 9.92 24 213735 1198 63274065
Rectal haemorrhage 22.37 9.92 87 213672 48943 63226320
Liver function test abnormal 22.30 9.92 85 213674 48096 63227167
Red cell distribution width increased 22.24 9.92 82 213677 10442 63264821
Red blood cells urine 22.14 9.92 17 213742 548 63274715
Blood creatinine decreased 22.03 9.92 54 213705 5491 63269772
Psychotic disorder 21.75 9.92 33 213726 25679 63249584
Carcinoid syndrome 21.73 9.92 10 213749 120 63275143
Coronary artery disease 21.65 9.92 48 213711 32329 63242934
Colon cancer stage 0 21.15 9.92 5 213754 3 63275260
Peripheral venous disease 21.06 9.92 13 213746 15464 63259799
Total lung capacity decreased 20.97 9.92 31 213728 2152 63273111
Subarachnoid haemorrhage 20.87 9.92 11 213748 14272 63260991
Cerebral microhaemorrhage 20.75 9.92 10 213749 134 63275129
Hypercalcaemia 20.61 9.92 40 213719 28282 63246981
Agranulocytosis 20.55 9.92 33 213726 25101 63250162
No adverse event 20.51 9.92 71 213688 41334 63233929
Contusion 20.31 9.92 369 213390 149675 63125588
Band neutrophil count increased 20.29 9.92 14 213745 381 63274882
Tooth erosion 20.23 9.92 15 213744 458 63274805
Cataract 20.23 9.92 111 213648 56942 63218321
Urine oxalate increased 20.21 9.92 12 213747 250 63275013
International normalised ratio increased 20.16 9.92 84 213675 46341 63228922
Injection site pruritus 19.98 9.92 81 213678 45035 63230228
Cerebral infarction 19.89 9.92 31 213728 23862 63251401
Oral pruritus 19.84 9.92 31 213728 2260 63273003
Abortion induced 19.83 9.92 5 213754 10237 63265026
Excessive eye blinking 19.83 9.92 23 213736 1257 63274006
Photophobia 19.75 9.92 114 213645 17521 63257742
Muscle tension dysphonia 19.70 9.92 11 213748 203 63275060
Respiratory depression 19.40 9.92 11 213748 13704 63261559
Magnesium deficiency 19.32 9.92 16 213743 576 63274687
Conjunctivitis 19.25 9.92 128 213631 20668 63254595
Joint dislocation 19.13 9.92 21 213738 18779 63256484
Aggression 19.08 9.92 31 213728 23467 63251796
Spinal fracture 19.05 9.92 20 213739 18251 63257012
Aspartate aminotransferase increased 19.03 9.92 203 213556 90074 63185189
Polymenorrhoea 19.01 9.92 22 213737 1199 63274064
Musculoskeletal disorder 18.95 9.92 25 213734 20619 63254644
Precancerous condition 18.89 9.92 12 213747 283 63274980
Hepatic cirrhosis 18.83 9.92 34 213725 24700 63250563
Epiglottic cancer 18.79 9.92 4 213755 0 63275263
Endocrine neoplasm malignant 18.79 9.92 4 213755 0 63275263
Follicular lymphoma stage III 18.79 9.92 4 213755 0 63275263
Rectal cancer stage IV 18.79 9.92 4 213755 0 63275263
Cardiac neoplasm malignant 18.79 9.92 4 213755 0 63275263
Bladder cancer stage I, without cancer in situ 18.79 9.92 4 213755 0 63275263
Illness 18.77 9.92 93 213666 48966 63226297
Myelocyte count increased 18.73 9.92 13 213746 357 63274906
Respiratory disorder 18.70 9.92 68 213691 39014 63236249
Protein urine present 18.63 9.92 54 213705 6066 63269197
Systemic mastocytosis 18.59 9.92 10 213749 171 63275092
Abdominal pain upper 18.46 9.92 861 212898 205583 63069680
Nasal sinus cancer 18.41 9.92 6 213753 25 63275238
Night sweats 18.41 9.92 93 213666 48721 63226542
Chronic spontaneous urticaria 18.28 9.92 21 213738 1136 63274127
Bronchitis 18.28 9.92 303 213456 124632 63150631
Bronchospasm 18.25 9.92 110 213649 17170 63258093
Angioedema 18.21 9.92 244 213515 47721 63227542
Subdural haematoma 18.20 9.92 13 213746 14315 63260948
Toxic shock syndrome 18.11 9.92 18 213741 824 63274439
Procedural pain 17.94 9.92 28 213731 21541 63253722
Rectal cancer metastatic 17.87 9.92 11 213748 245 63275018
Blood calcium decreased 17.86 9.92 39 213720 26412 63248851
Cellulitis 17.80 9.92 183 213576 81775 63193488
X-ray abnormal 17.68 9.92 3 213756 8107 63267156
Tonsillar haemorrhage 17.68 9.92 11 213748 250 63275013
Antinuclear antibody positive 17.47 9.92 63 213696 7936 63267327
Muscle spasticity 17.46 9.92 29 213730 21765 63253498
Triple negative breast cancer 17.43 9.92 9 213750 141 63275122
Splenic neoplasm malignancy unspecified 17.41 9.92 5 213754 12 63275251
Depression 17.39 9.92 516 213243 195976 63079287
Tuberculosis 17.34 9.92 8 213751 11203 63264060
Medication error 17.31 9.92 104 213655 52180 63223083
Skin necrosis 17.27 9.92 13 213746 13937 63261326
Ocular hyperaemia 17.16 9.92 144 213615 25000 63250263
Pharyngeal swelling 17.14 9.92 54 213705 6350 63268913
Injection site haemorrhage 17.13 9.92 35 213724 24279 63250984
Pneumocystis jirovecii pneumonia 17.10 9.92 19 213740 16895 63258368
Enthesopathy 17.08 9.92 4 213755 8610 63266653
Myelocyte percentage increased 17.03 9.92 10 213749 204 63275059
Device issue 16.95 9.92 34 213725 23747 63251516
Respiratory depth decreased 16.92 9.92 6 213753 34 63275229
Surgery 16.85 9.92 63 213696 35849 63239414
Electrocardiogram QT prolonged 16.85 9.92 288 213471 59242 63216021
Bladder cancer recurrent 16.83 9.92 9 213750 152 63275111
Brain neoplasm 16.80 9.92 42 213717 4324 63270939
Pleural effusion 16.79 9.92 217 213542 92993 63182270
Infusion site streaking 16.74 9.92 14 213745 511 63274752
Premenstrual syndrome 16.64 9.92 16 213743 703 63274560
Bezoar 16.61 9.92 23 213736 1503 63273760
Drug dependence 16.61 9.92 36 213723 24447 63250816
Mean cell haemoglobin increased 16.61 9.92 33 213726 2910 63272353
Breast calcifications 16.59 9.92 21 213738 1257 63274006
Intestinal metaplasia 16.56 9.92 4 213755 3 63275260
Sickle cell trait 16.56 9.92 4 213755 3 63275260
Myocarditis 16.55 9.92 7 213752 10318 63264945
Incorrect route of product administration 16.53 9.92 43 213716 27409 63247854
Cardiomyopathy 16.44 9.92 21 213738 17563 63257700
Flank pain 16.41 9.92 103 213656 16307 63258956
Colitis ulcerative 16.38 9.92 40 213719 26051 63249212
Live birth 16.33 9.92 39 213720 25591 63249672
Infusion site pain 16.32 9.92 105 213654 16764 63258499
Bone marrow failure 16.06 9.92 48 213711 29242 63246021
Sinus rhythm 16.05 9.92 17 213742 839 63274424
Device malfunction 16.01 9.92 22 213737 17835 63257428
Coagulopathy 15.85 9.92 28 213731 20516 63254747
Joint injury 15.83 9.92 49 213710 29523 63245740
Lymphadenopathy 15.83 9.92 71 213688 38387 63236876
Tenderness 15.78 9.92 130 213629 22448 63252815
Affect lability 15.69 9.92 9 213750 11142 63264121
Endometrial cancer 15.67 9.92 34 213725 3191 63272072
Thyroid stimulating immunoglobulin increased 15.67 9.92 7 213752 78 63275185
Hepatocellular injury 15.65 9.92 44 213715 27337 63247926
Infusion site haemorrhage 15.60 9.92 45 213714 5041 63270222
Sleep disorder due to a general medical condition 15.56 9.92 11 213748 12177 63263086
Localised infection 15.51 9.92 51 213708 30159 63245104
Lipaemic index score 15.43 9.92 7 213752 81 63275182
Suicidal ideation 15.42 9.92 135 213624 62286 63212977
Red blood cell count increased 15.34 9.92 33 213726 3079 63272184
Feeling jittery 15.24 9.92 87 213672 13316 63261947
Weight decreased 15.22 9.92 769 212990 276029 62999234
Adrenal insufficiency 15.15 9.92 23 213736 17892 63257371
Bilirubin urine present 15.14 9.92 7 213752 85 63275178
Back pain 15.14 9.92 1058 212701 263087 63012176
Rectal cancer stage III 15.13 9.92 5 213754 22 63275241
Breast disorder female 15.07 9.92 8 213751 133 63275130
Exostosis 15.04 9.92 23 213736 17839 63257424
Hepatic function abnormal 15.03 9.92 69 213690 37073 63238190
Crystalluria 15 9.92 12 213747 411 63274852
Sarcoma 14.98 9.92 14 213745 593 63274670
Haematochezia 14.98 9.92 112 213647 53432 63221831
Head injury 14.95 9.92 45 213714 27351 63247912
Lung opacity 14.94 9.92 33 213726 3135 63272128
Product storage error 14.90 9.92 17 213742 14939 63260324
Hepatotoxicity 14.88 9.92 69 213690 36972 63238291
Anti-thyroid antibody positive 14.83 9.92 12 213747 418 63274845
Exposure via body fluid 14.81 9.92 14 213745 602 63274661
Cardiotoxicity 14.72 9.92 5 213754 8433 63266830
Skin exfoliation 14.66 9.92 85 213674 43017 63232246
Leukocyturia 14.53 9.92 21 213738 1428 63273835
Product prescribing error 14.47 9.92 43 213716 26246 63249017
Musculoskeletal pain 14.43 9.92 221 213538 92056 63183207
Obesity 14.41 9.92 52 213707 29900 63245363
Haemophagocytic lymphohistiocytosis 14.36 9.92 9 213750 10618 63264645
Osteonecrosis 14.33 9.92 39 213720 24491 63250772
Blood thyroid stimulating hormone increased 14.33 9.92 55 213704 7139 63268124
COVID-19 pneumonia 14.32 9.92 16 213743 14193 63261070
Glomerulonephritis chronic 14.31 9.92 8 213751 148 63275115
Respiratory arrest 14.21 9.92 59 213700 32586 63242677
Oesophageal neoplasm 14.09 9.92 3 213756 0 63275263
Head and neck cancer stage IV 14.09 9.92 3 213756 0 63275263
Gastric cancer recurrent 14.09 9.92 3 213756 0 63275263
Prostate cancer stage III 14.09 9.92 3 213756 0 63275263
Rectal cancer stage II 14.09 9.92 3 213756 0 63275263
Amastia 14.09 9.92 3 213756 0 63275263
C-kit gene mutation 14.09 9.92 3 213756 0 63275263
Endometrial cancer stage IV 14.09 9.92 3 213756 0 63275263
Hypersensitivity 14.07 9.92 824 212935 291861 62983402
HER2 positive breast cancer 14.05 9.92 11 213748 365 63274898
Injection site swelling 14.03 9.92 98 213661 47474 63227789
Thyroid cancer metastatic 13.99 9.92 8 213751 155 63275108
Breast cancer recurrent 13.89 9.92 39 213720 4302 63270961
Urobilinogen urine increased 13.88 9.92 10 213749 292 63274971
Tryptase increased 13.87 9.92 11 213748 372 63274891
Product quality issue 13.71 9.92 68 213691 35797 63239466
Myelodysplastic syndrome 13.70 9.92 22 213737 16732 63258531
Laryngeal cancer 13.67 9.92 8 213751 162 63275101
Hip fracture 13.64 9.92 52 213707 29422 63245841
Upper limb fracture 13.62 9.92 27 213732 18941 63256322
Eyelid skin dryness 13.59 9.92 8 213751 164 63275099
Generalised tonic-clonic seizure 13.55 9.92 51 213708 28965 63246298
Status epilepticus 13.42 9.92 19 213740 15214 63260049
Hepatic failure 13.41 9.92 68 213691 35588 63239675
Dizziness 13.35 9.92 1256 212503 428669 62846594
Eye disorder 13.30 9.92 36 213723 22649 63252614
Pneumonia viral 13.30 9.92 5 213754 7917 63267346
Overflow diarrhoea 13.26 9.92 7 213752 115 63275148
Acute hepatic failure 13.24 9.92 26 213733 18301 63256962
Dyskinesia 13.22 9.92 59 213700 31943 63243320
Macroglossia 13.22 9.92 14 213745 691 63274572
Nasal ulcer 13.20 9.92 26 213733 2278 63272985
Monocyte count decreased 13.20 9.92 25 213734 2128 63273135
Rectal cancer 13.16 9.92 25 213734 2133 63273130
Fibromyalgia 13.13 9.92 191 213568 80229 63195034
Foot operation 13.12 9.92 4 213755 7227 63268036
Suspected suicide 13.12 9.92 3 213756 6565 63268698
Cervix disorder 13.10 9.92 13 213746 594 63274669
Cardiac arrest 13.03 9.92 226 213533 92319 63182944
Vasculitis 13.01 9.92 26 213733 18183 63257080
Facet joint syndrome 12.98 9.92 13 213746 12125 63263138
Gestational diabetes 12.97 9.92 6 213753 8390 63266873
Barotrauma 12.93 9.92 8 213751 180 63275083
Product administration error 12.79 9.92 36 213723 22361 63252902
Drug ineffective for unapproved indication 12.78 9.92 65 213694 33998 63241265
Pulmonary hypertension 12.74 9.92 73 213686 37050 63238213
Palmar erythema 12.72 9.92 22 213737 1745 63273518
Maternal exposure timing unspecified 12.72 9.92 4 213755 7083 63268180
Pituitary apoplexy 12.69 9.92 7 213752 126 63275137
Ankylosing spondylitis 12.66 9.92 10 213749 10464 63264799
Pathogen resistance 12.63 9.92 3 213756 6395 63268868
Febrile neutropenia 12.58 9.92 303 213456 118146 63157117
Pulmonary oedema 12.55 9.92 121 213638 54752 63220511
Transient ischaemic attack 12.55 9.92 75 213684 37678 63237585
Cardiogenic shock 12.47 9.92 26 213733 17906 63257357
Product dose omission in error 12.46 9.92 5 213754 7607 63267656
Vaginal cancer 12.42 9.92 9 213750 265 63274998
Pelvic fracture 12.42 9.92 16 213743 13332 63261931
Vaginal haemorrhage 12.39 9.92 49 213710 27438 63247825
Interstitial lung disease 12.33 9.92 141 213618 61767 63213496
Hallucination, auditory 12.32 9.92 15 213744 12809 63262454
Infusion site thrombosis 12.31 9.92 7 213752 134 63275129
Lung cancer metastatic 12.31 9.92 27 213732 2553 63272710
Injection site induration 12.21 9.92 8 213751 9218 63266045
Urethral pain 12.19 9.92 10 213749 355 63274908
Product substitution issue 12.16 9.92 22 213737 15974 63259289
Invasive lobular breast carcinoma 12.09 9.92 15 213744 880 63274383
Cardiac disorder 12.07 9.92 111 213648 50705 63224558
B-cell lymphoma stage II 12.02 9.92 3 213756 3 63275260
Endocrine neoplasm 12.02 9.92 3 213756 3 63275260
Walking aid user 12.02 9.92 11 213748 10706 63264557
Mental status changes 11.97 9.92 81 213678 39518 63235745
Injection site urticaria 11.96 9.92 18 213741 14055 63261208
Eosinophil percentage increased 11.95 9.92 16 213743 1013 63274250
Defaecation urgency 11.91 9.92 36 213723 4139 63271124
Polyarthritis 11.88 9.92 10 213749 10136 63265127
Inappropriate schedule of product administration 11.87 9.92 263 213496 103702 63171561
Mucosal inflammation 11.85 9.92 223 213536 46705 63228558
Unintentional medical device removal 11.81 9.92 3 213756 6112 63269151
Aphasia 11.81 9.92 64 213695 32936 63242327
Second primary malignancy 11.80 9.92 6 213753 7947 63267316
Specific gravity urine increased 11.78 9.92 8 213751 212 63275051
Neoplasm progression 11.78 9.92 73 213686 36355 63238908
Acute respiratory failure 11.73 9.92 68 213691 34417 63240846
Anuria 11.72 9.92 15 213744 12536 63262727
Genital haemorrhage 11.70 9.92 5 213754 7327 63267936
Injection site rash 11.68 9.92 29 213730 18780 63256483
Diffuse large B-cell lymphoma 11.67 9.92 4 213755 6708 63268555
Bone disorder 11.66 9.92 35 213724 21291 63253972
Leiomyosarcoma 11.62 9.92 8 213751 217 63275046
Bruxism 11.61 9.92 32 213727 3493 63271770
Seizure 11.55 9.92 349 213410 132285 63142978
Arrhythmia 11.53 9.92 78 213681 38062 63237201
Sickle cell anaemia with crisis 11.49 9.92 3 213756 6000 63269263
Aplastic anaemia 11.47 9.92 63 213696 9506 63265757
Malignant anorectal neoplasm 11.38 9.92 4 213755 22 63275241
Lip swelling 11.37 9.92 157 213602 30906 63244357
Emphysema 11.37 9.92 12 213747 10926 63264337
Pneumonitis 11.17 9.92 71 213688 35151 63240112
Haematoma 11.14 9.92 70 213689 34750 63240513
Gastritis 11.12 9.92 182 213577 37121 63238142
Wound infection 11.09 9.92 36 213723 21374 63253889
Salivary hypersecretion 11.06 9.92 6 213753 7660 63267603
Lichen sclerosus 11.02 9.92 16 213743 1093 63274170
Diabetic ketoacidosis 10.96 9.92 34 213725 20471 63254792
Lymphorrhoea 10.86 9.92 5 213754 60 63275203
Malignant melanoma stage IV 10.82 9.92 4 213755 26 63275237
Metastatic lymphoma 10.81 9.92 7 213752 171 63275092
Liver disorder 10.80 9.92 122 213637 53565 63221698
Splenomegaly 10.77 9.92 13 213746 11144 63264119
Hypoaesthesia oral 10.75 9.92 78 213681 12955 63262308
Therapy partial responder 10.74 9.92 12 213747 10646 63264617
Oligohydramnios 10.72 9.92 4 213755 6362 63268901
Multiple fractures 10.71 9.92 8 213751 8610 63266653
Salivary gland cancer 10.70 9.92 7 213752 174 63275089
Anisomastia 10.69 9.92 4 213755 27 63275236
Drug tolerance 10.68 9.92 5 213754 6944 63268319
Laryngitis 10.66 9.92 26 213733 16941 63258322
Hyperglycaemia 10.59 9.92 90 213669 41777 63233486
Thyroid stimulating immunoglobulin 10.58 9.92 5 213754 64 63275199
Device breakage 10.57 9.92 14 213745 11528 63263735
Bile duct cancer 10.52 9.92 12 213747 644 63274619
Dystonia 10.51 9.92 19 213740 13800 63261463
Malignant splenic neoplasm 10.50 9.92 3 213756 7 63275256
Laryngospasm 10.49 9.92 28 213731 3000 63272263
Muscle rigidity 10.48 9.92 14 213745 11486 63263777
Anosmia 10.45 9.92 5 213754 6855 63268408
Visual acuity reduced 10.43 9.92 38 213721 21788 63253475
Blood creatine phosphokinase increased 10.35 9.92 60 213699 30370 63244893
Glaucoma 10.35 9.92 31 213728 18874 63256389
Pulmonary arterial hypertension 10.34 9.92 40 213719 22537 63252726
Ulcerative gastritis 10.33 9.92 4 213755 30 63275233
Malignant neoplasm of renal pelvis 10.33 9.92 4 213755 30 63275233
Cytomegalovirus infection 10.33 9.92 36 213723 20916 63254347
Throat irritation 10.24 9.92 181 213578 37466 63237797
Purpura 10.23 9.92 14 213745 11371 63263892
Post-traumatic neck syndrome 10.23 9.92 22 213737 2052 63273211
Precancerous cells present 10.22 9.92 18 213741 1449 63273814
Injection site bruising 10.19 9.92 91 213668 41819 63233444
Lobular breast carcinoma in situ 10.18 9.92 5 213754 70 63275193
Basal cell carcinoma 10.17 9.92 54 213705 27937 63247326
Pulpitis dental 10.12 9.92 14 213745 914 63274349
Retinal artery embolism 10.12 9.92 5 213754 71 63275192
Metastases to liver 10.12 9.92 43 213716 23596 63251667
End stage renal disease 10.09 9.92 47 213712 6646 63268617
Post procedural complication 10.08 9.92 27 213732 17047 63258216
Temperature intolerance 10.07 9.92 58 213701 8906 63266357
Ureteric cancer 10.06 9.92 5 213754 72 63275191
White blood cells urine 10.02 9.92 10 213749 460 63274803
Eosinophilia 9.99 9.92 41 213718 22715 63252548
Dystrophic calcification 9.98 9.92 6 213753 128 63275135
Haemorrhage foetal 9.96 9.92 3 213756 9 63275254
Foot fracture 9.93 9.92 44 213715 23870 63251393

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Prostate cancer 41886.93 11.30 12440 134704 27209 34782578
Bladder cancer 24563.09 11.30 6773 140371 9505 34800282
Oesophageal carcinoma 19821.21 11.30 5092 142052 4212 34805575
Renal cancer 15180.68 11.30 3969 143175 3766 34806021
Colorectal cancer 14574.17 11.30 3489 143655 1272 34808515
Prostate cancer stage I 11148.04 11.30 2505 144639 84 34809703
Prostate cancer stage IV 9980.54 11.30 2269 144875 199 34809588
Prostate cancer stage II 8937.12 11.30 2044 145100 237 34809550
Colorectal cancer stage III 8166.62 11.30 1825 145319 11 34809776
Prostate cancer stage III 7820.57 11.30 1754 145390 39 34809748
Colorectal cancer stage IV 7320.64 11.30 1634 145510 0 34809787
Hepatic cancer stage IV 6307.04 11.30 1408 145736 0 34809787
Gastric cancer 5406.18 11.30 1710 145434 4759 34805028
Hepatic cancer 5267.45 11.30 1780 145364 6495 34803292
Renal cancer stage IV 4815.67 11.30 1076 146068 3 34809784
Pancreatic carcinoma stage IV 4573.87 11.30 1043 146101 102 34809685
Colorectal cancer stage II 4536.31 11.30 1013 146131 0 34809787
Renal cancer stage I 4127.71 11.30 926 146218 19 34809768
Gastric cancer stage IV 3818.56 11.30 857 146287 19 34809768
Bladder cancer stage II 3651.24 11.30 819 146325 16 34809771
Pancreatic carcinoma 3647.65 11.30 1382 145762 7519 34802268
Bladder cancer stage IV 3420.62 11.30 764 146380 0 34809787
Renal cancer stage III 3138.46 11.30 703 146441 9 34809778
Testis cancer 3120.44 11.30 800 146344 629 34809158
Colorectal cancer stage I 3093.61 11.30 691 146453 0 34809787
Lung carcinoma cell type unspecified stage IV 3027.61 11.30 744 146400 377 34809410
Renal cancer stage II 2959.23 11.30 661 146483 0 34809787
Gastrointestinal carcinoma 2814.74 11.30 778 146366 1070 34808717
Bladder cancer stage III 2789.03 11.30 623 146521 0 34809787
Prostate cancer stage 0 1754.59 11.30 392 146752 0 34809787
Lung neoplasm malignant 1745.68 11.30 1021 146123 16374 34793413
Gastric cancer stage I 1732.20 11.30 387 146757 0 34809787
Skin cancer 1710.34 11.30 845 146299 9452 34800335
Gastric cancer stage III 1509.07 11.30 340 146804 13 34809774
Haematological malignancy 1465.67 11.30 357 146787 161 34809626
Gastric cancer stage II 1302.41 11.30 291 146853 0 34809787
Throat cancer 1155.67 11.30 357 146787 888 34808899
Pancreatic carcinoma stage II 1136.78 11.30 254 146890 0 34809787
Brain neoplasm malignant 1080.08 11.30 311 146833 543 34809244
Neoplasm malignant 1050.11 11.30 782 146362 19123 34790664
Thyroid cancer 1034.84 11.30 353 146791 1327 34808460
Pancreatic carcinoma stage III 1026.00 11.30 231 146913 8 34809779
Hepatic cancer stage III 921.93 11.30 206 146938 0 34809787
Lung carcinoma cell type unspecified stage I 910.60 11.30 205 146939 7 34809780
Lung carcinoma cell type unspecified stage III 850.31 11.30 190 146954 0 34809787
Pancreatic carcinoma stage I 760.79 11.30 170 146974 0 34809787
Hepatic cancer stage II 716.03 11.30 160 146984 0 34809787
Hepatic cancer stage I 702.61 11.30 157 146987 0 34809787
Drug ineffective 664.65 11.30 571 146573 456180 34353607
Bone cancer 616.65 11.30 236 146908 1320 34808467
Lung carcinoma cell type unspecified stage II 541.48 11.30 121 147023 0 34809787
Disease progression 507.64 11.30 1286 145858 106791 34702996
Death 485.40 11.30 579 146565 397470 34412317
Off label use 484.79 11.30 636 146508 418888 34390899
Breast cancer male 475.88 11.30 140 147004 274 34809513
Appendix cancer 423.81 11.30 96 147048 6 34809781
Bladder cancer stage I, with cancer in situ 384.85 11.30 86 147058 0 34809787
Toxicity to various agents 371.66 11.30 190 146954 200172 34609615
Small intestine carcinoma 369.35 11.30 128 147016 510 34809277
Prostatic disorder 351.94 11.30 203 146941 3159 34806628
Breast cancer stage I 340.09 11.30 76 147068 0 34809787
Thyroid cancer stage IV 331.14 11.30 74 147070 0 34809787
Thyroid cancer stage I 317.72 11.30 71 147073 0 34809787
Breast cancer stage II 308.77 11.30 69 147075 0 34809787
Small intestine carcinoma stage IV 299.82 11.30 67 147077 0 34809787
Diarrhoea 254.56 11.30 820 146324 389092 34420695
Colon cancer stage IV 241.64 11.30 71 147073 138 34809649
Completed suicide 239.81 11.30 59 147085 98109 34711678
Drug abuse 219.05 11.30 72 147072 99024 34710763
Fatigue 210.73 11.30 826 146318 369827 34439960
Pneumonia 210.72 11.30 801 146343 361826 34447961
Breast cancer stage III 210.32 11.30 47 147097 0 34809787
Colorectal carcinoma stage 0 210.32 11.30 47 147097 0 34809787
Dyspnoea 209.57 11.30 847 146297 375935 34433852
Acute kidney injury 208.94 11.30 627 146517 304361 34505426
Gallbladder cancer 199.27 11.30 67 147077 238 34809549
Gastric cancer stage 0 198.89 11.30 47 147097 13 34809774
Anaemia 193.11 11.30 436 146708 232899 34576888
Breast cancer stage IV 192.42 11.30 43 147101 0 34809787
Colon cancer 191.57 11.30 208 146936 8413 34801374
Nausea 190.86 11.30 761 146383 339147 34470640
Thyroid cancer stage II 187.94 11.30 42 147102 0 34809787
Thyroid cancer stage III 187.94 11.30 42 147102 0 34809787
Pyrexia 186.68 11.30 746 146398 332267 34477520
Drug interaction 186.30 11.30 423 146721 225523 34584264
Colon cancer stage III 180.19 11.30 56 147088 143 34809644
General physical health deterioration 177.43 11.30 167 146977 128102 34681685
Fall 177.01 11.30 368 146776 202517 34607270
Condition aggravated 176.77 11.30 338 146806 191858 34617929
Nasal cavity cancer 174.39 11.30 55 147089 150 34809637
Cardiac failure 166.72 11.30 88 147056 91160 34718627
Arthralgia 161.67 11.30 293 146851 169748 34640039
Small intestine carcinoma stage III 161.09 11.30 36 147108 0 34809787
Sepsis 152.16 11.30 294 146850 166267 34643520
Uterine cancer 147.67 11.30 33 147111 0 34809787
Colon cancer stage II 144.62 11.30 40 147104 55 34809732
Lymphoma 143.08 11.30 217 146927 12290 34797497
Asthenia 137.45 11.30 549 146595 244702 34565085
Colon cancer stage I 135.30 11.30 32 147112 9 34809778
Gallbladder cancer stage IV 134.24 11.30 30 147114 0 34809787
Drug intolerance 133.85 11.30 42 147102 59528 34750259
Product use in unapproved indication 131.98 11.30 181 146963 117318 34692469
Tongue carcinoma stage IV 129.77 11.30 29 147115 0 34809787
Adrenal gland cancer 126.54 11.30 32 147112 22 34809765
Multiple organ dysfunction syndrome 121.55 11.30 87 147057 76479 34733308
Vomiting 118.98 11.30 587 146557 247034 34562753
COVID-19 114.35 11.30 95 147049 77455 34732332
Disability 112.97 11.30 119 147025 4646 34805141
Dizziness 112.60 11.30 505 146639 218016 34591771
Oedema peripheral 111.52 11.30 209 146935 119603 34690184
Tongue neoplasm malignant stage unspecified 110.59 11.30 55 147089 623 34809164
Hypotension 109.01 11.30 521 146623 221128 34588659
Pain in extremity 108.90 11.30 231 146913 126282 34683505
Myocardial infarction 107.68 11.30 217 146927 120868 34688919
Rash 105.27 11.30 531 146613 222221 34587566
Malignant neoplasm progression 103.57 11.30 131 147013 87915 34721872
Incorrect dose administered 103.30 11.30 390 146754 40125 34769662
Suicide attempt 102.56 11.30 20 147124 39096 34770691
Neutropenia 102.29 11.30 329 146815 156449 34653338
Lung carcinoma cell type unspecified stage 0 101.45 11.30 28 147116 38 34809749
Weight decreased 100.98 11.30 391 146753 175910 34633877
Pancytopenia 100.51 11.30 153 146991 95004 34714783
Lip and/or oral cavity cancer 99.38 11.30 43 147101 344 34809443
Leukaemia 98.68 11.30 109 147035 4494 34805293
Febrile neutropenia 98.01 11.30 275 146869 136574 34673213
Product dose omission issue 97.75 11.30 225 146919 119486 34690301
Treatment failure 96.20 11.30 38 147106 46659 34763128
Thrombocytopenia 95.71 11.30 337 146807 155910 34653877
Tongue carcinoma stage III 93.97 11.30 21 147123 0 34809787
Small intestine carcinoma stage I 93.97 11.30 21 147123 0 34809787
Small intestine carcinoma stage II 93.97 11.30 21 147123 0 34809787
Oesophageal carcinoma stage 0 93.97 11.30 21 147123 0 34809787
Respiratory failure 91.13 11.30 201 146943 108371 34701416
Intentional product use issue 91.02 11.30 71 147073 59745 34750042
Atrial fibrillation 90.59 11.30 242 146902 122151 34687636
Cardiac failure congestive 89.76 11.30 132 147012 83138 34726649
Pain 89.38 11.30 501 146643 204174 34605613
Overdose 88.14 11.30 155 146989 90904 34718883
Interstitial lung disease 87.85 11.30 87 147057 65195 34744592
Joint swelling 87.50 11.30 74 147070 59816 34749971
Malaise 86.02 11.30 446 146698 185379 34624408
Somnolence 85.83 11.30 215 146929 110901 34698886
Pancreatic carcinoma stage 0 85.02 11.30 19 147125 0 34809787
Peripheral swelling 84.80 11.30 119 147025 76422 34733365
Decreased appetite 84.75 11.30 386 146758 166006 34643781
Rheumatoid arthritis 84.05 11.30 28 147116 38210 34771577
Drug resistance 82.94 11.30 7 147137 25920 34783867
Renal impairment 81.78 11.30 172 146972 94341 34715446
Cerebrovascular accident 80.61 11.30 146 146998 84665 34725122
Coma 80.55 11.30 46 147098 45632 34764155
Thyroid cancer stage 0 80.55 11.30 18 147126 0 34809787
Intentional overdose 78.43 11.30 43 147101 43631 34766156
Headache 77.18 11.30 511 146633 200124 34609663
Depression 76.45 11.30 186 146958 96912 34712875
Laryngeal cancer stage I 76.07 11.30 17 147127 0 34809787
Weight increased 75.81 11.30 175 146969 92858 34716929
Pulmonary embolism 75.42 11.30 166 146978 89580 34720207
Drug hypersensitivity 75.31 11.30 140 147004 80389 34729398
Anhedonia 74.85 11.30 123 147021 7462 34802325
Dehydration 74.52 11.30 288 146856 129681 34680106
Rhabdomyolysis 74.49 11.30 107 147037 68056 34741731
Gait disturbance 74.45 11.30 154 146990 84986 34724801
Myalgia 72.82 11.30 153 146991 83957 34725830
Bladder cancer recurrent 69.63 11.30 34 147110 369 34809418
Back pain 69.09 11.30 271 146873 121518 34688269
Confusional state 68.95 11.30 342 146802 143818 34665969
Tremor 67.56 11.30 155 146989 82432 34727355
Cardiac arrest 67.50 11.30 195 146949 95964 34713823
Tongue carcinoma stage II 67.12 11.30 15 147129 0 34809787
Laryngeal cancer 66.63 11.30 41 147103 722 34809065
Pleural effusion 65.94 11.30 154 146990 81392 34728395
Renal failure 65.18 11.30 305 146839 130252 34679535
Loss of personal independence in daily activities 65.12 11.30 29 147115 33150 34776637
Injection site pain 64.98 11.30 42 147102 38963 34770824
Septic shock 64.44 11.30 128 147016 71706 34738081
Syncope 63.79 11.30 186 146958 91265 34718522
Tonsil cancer 62.85 11.30 46 147098 1092 34808695
Cardio-respiratory arrest 61.14 11.30 86 147058 55187 34754600
Hepatic function abnormal 60.98 11.30 58 147086 44305 34765482
Alanine aminotransferase increased 60.36 11.30 159 146985 80656 34729131
Cough 59.41 11.30 379 146765 149761 34660026
Lactic acidosis 58.52 11.30 37 147107 34735 34775052
Laryngeal cancer stage IV 58.36 11.30 15 147129 12 34809775
Abdominal pain 57.83 11.30 427 146717 163191 34646596
Hepatic cancer metastatic 57.50 11.30 37 147107 707 34809080
Constipation 57.20 11.30 340 146804 136642 34673145
Muscular weakness 57.08 11.30 140 147004 72757 34737030
Therapeutic product effect decreased 57.07 11.30 38 147106 34705 34775082
Infection 57.01 11.30 194 146950 90721 34719066
Intentional product misuse 56.65 11.30 65 147079 45546 34764241
Seizure 56.52 11.30 238 146906 104619 34705168
Hyperkalaemia 56.13 11.30 131 147013 69258 34740529
Muscle spasms 55.68 11.30 148 146996 74853 34734934
Bone cancer metastatic 55.36 11.30 24 147120 193 34809594
Blood pressure decreased 55.16 11.30 82 147062 51433 34758354
Encephalopathy 54.89 11.30 41 147103 35278 34774509
Hypoglycaemia 54.69 11.30 91 147053 54549 34755238
C-reactive protein increased 54.23 11.30 90 147054 54008 34755779
Oesophageal cancer metastatic 53.74 11.30 27 147117 313 34809474
Head and neck cancer stage IV 53.70 11.30 12 147132 0 34809787
Blood creatinine increased 53.42 11.30 212 146932 94764 34715023
COVID-19 pneumonia 53.14 11.30 5 147139 16962 34792825
Hyponatraemia 52.15 11.30 176 146968 82515 34727272
Arthropathy 52.05 11.30 24 147120 26883 34782904
Hyperhidrosis 52.02 11.30 155 146989 75537 34734250
Haematochezia 51.87 11.30 72 147072 46462 34763325
Chest pain 51.68 11.30 317 146827 126445 34683342
Hypertension 51.16 11.30 350 146794 136093 34673694
Deep vein thrombosis 50.54 11.30 126 147018 65122 34744665
Blood creatine phosphokinase increased 50.41 11.30 69 147075 44788 34764999
Hepatic enzyme increased 50.39 11.30 54 147090 39026 34770761
Cytokine release syndrome 49.84 11.30 17 147127 22860 34786927
Therapeutic product effect incomplete 49.82 11.30 85 147059 50456 34759331
Acute myocardial infarction 49.67 11.30 94 147050 53625 34756162
Platelet count decreased 49.52 11.30 298 146846 119419 34690368
Musculoskeletal stiffness 49.31 11.30 75 147069 46605 34763182
Haemoglobin decreased 49.24 11.30 302 146842 120470 34689317
Gallbladder cancer stage I 49.22 11.30 11 147133 0 34809787
Tongue carcinoma stage I 49.22 11.30 11 147133 0 34809787
Ascites 49.02 11.30 75 147069 46496 34763291
Blood glucose increased 48.50 11.30 133 147011 66585 34743202
Blood cholesterol 48.15 11.30 22 147122 203 34809584
Neuropathy peripheral 48.01 11.30 184 146960 83079 34726708
Neuroendocrine carcinoma 47.96 11.30 27 147117 400 34809387
Thrombosis 47.80 11.30 87 147057 50371 34759416
Drug ineffective for unapproved indication 47.69 11.30 20 147124 23695 34786092
Shock 47.66 11.30 21 147123 24158 34785629
Clear cell renal cell carcinoma 47.31 11.30 39 147105 1108 34808679
Abnormal behaviour 47.18 11.30 23 147121 24946 34784841
Epistaxis 47.08 11.30 110 147034 58141 34751646
Hypokalaemia 47.00 11.30 110 147034 58104 34751683
Foetal exposure during pregnancy 46.56 11.30 55 147089 38046 34771741
Cerebral haemorrhage 46.48 11.30 47 147097 34890 34774897
Aspartate aminotransferase increased 46.43 11.30 139 147005 67644 34742143
Urethral cancer 46.13 11.30 17 147127 84 34809703
Insomnia 46.00 11.30 253 146891 103654 34706133
Metabolic acidosis 45.35 11.30 71 147073 43609 34766178
Altered state of consciousness 44.94 11.30 20 147124 22873 34786914
Bradycardia 44.56 11.30 165 146979 75253 34734534
Suicidal ideation 44.50 11.30 63 147081 40325 34769462
Synovitis 44.44 11.30 4 147140 14062 34795725
Psoriatic arthropathy 44.38 11.30 14 147130 19784 34790003
Arrhythmia 43.42 11.30 52 147092 35756 34774031
Therapy non-responder 43.20 11.30 61 147083 39085 34770702
Myelosuppression 42.52 11.30 14 147130 19251 34790536
Deformity 42.24 11.30 42 147102 1530 34808257
Neuroleptic malignant syndrome 41.43 11.30 12 147132 17922 34791865
Hypoxia 41.43 11.30 108 147036 54987 34754800
Hypoaesthesia 41.37 11.30 127 147017 61317 34748470
Stress 41.32 11.30 40 147104 30307 34779480
Chronic obstructive pulmonary disease 40.65 11.30 91 147053 48827 34760960
Transaminases increased 40.58 11.30 32 147112 26791 34782996
Psoriasis 40.37 11.30 63 147081 38749 34771038
Gallbladder cancer stage III 40.27 11.30 9 147135 0 34809787
Unevaluable event 39.86 11.30 47 147097 32543 34777244
Inappropriate schedule of product administration 39.68 11.30 132 147012 62164 34747623
Reversible airways obstruction 39.48 11.30 25 147119 464 34809323
Victim of child abuse 39.24 11.30 32 147112 895 34808892
Brain cancer metastatic 39.04 11.30 16 147128 110 34809677
Oedema 38.90 11.30 84 147060 45657 34764130
Accidental overdose 38.90 11.30 18 147126 20122 34789665
Aggression 38.88 11.30 65 147079 38899 34770888
Laryngeal cancer stage III 38.37 11.30 10 147134 9 34809778
Feeling abnormal 38.24 11.30 137 147007 63098 34746689
Memory impairment 38.14 11.30 78 147066 43240 34766547
Balance disorder 37.70 11.30 71 147073 40583 34769204
White blood cell count decreased 37.68 11.30 241 146903 95204 34714583
Therapeutic response decreased 37.24 11.30 41 147103 29272 34780515
Malignant neoplasm of spinal cord 37.23 11.30 11 147133 22 34809765
Accidental exposure to product 37.01 11.30 5 147139 12797 34796990
Hepatic failure 36.93 11.30 55 147089 34476 34775311
Haemorrhage 36.89 11.30 103 147041 51267 34758520
Urinary tract infection 36.51 11.30 206 146938 83875 34725912
Product use issue 36.24 11.30 140 147004 63076 34746711
Loss of consciousness 36.19 11.30 202 146942 82465 34727322
Gastrointestinal haemorrhage 36.17 11.30 221 146923 88256 34721531
Contraindicated product administered 35.95 11.30 23 147121 21458 34788329
Pulmonary oedema 35.86 11.30 93 147051 47436 34762351
Abdominal distension 35.85 11.30 126 147018 58366 34751421
Liver disorder 35.83 11.30 52 147092 32945 34776842
Rectal cancer stage III 35.80 11.30 8 147136 0 34809787
Bladder cancer stage I, without cancer in situ 35.80 11.30 8 147136 0 34809787
Haematoma 35.74 11.30 33 147111 25572 34784215
Ischaemic stroke 35.73 11.30 16 147128 18234 34791553
Arthritis 35.43 11.30 48 147096 31298 34778489
Cerebral infarction 35.32 11.30 38 147106 27417 34782370
Palpitations 35.21 11.30 72 147072 39914 34769873
Eosinophilia 35.20 11.30 35 147109 26187 34783600
Wrong technique in product usage process 35.02 11.30 61 147083 35925 34773862
Vision blurred 34.63 11.30 90 147054 45873 34763914
Visual impairment 34.56 11.30 61 147083 35741 34774046
Sopor 34.47 11.30 5 147139 12131 34797656
Vertigo 34.37 11.30 34 147110 25502 34784285
Incorrect route of product administration 34.17 11.30 10 147134 14835 34794952
Musculoskeletal pain 34.09 11.30 51 147093 31912 34777875
Appendicitis 34.04 11.30 10 147134 14797 34794990
Chills 33.88 11.30 201 146943 80842 34728945
Cellulitis 33.85 11.30 112 147032 52839 34756948
Fluid retention 33.72 11.30 38 147106 26849 34782938
Pruritus 33.64 11.30 409 146735 141572 34668215
Ureteric cancer 33.62 11.30 17 147127 200 34809587
Gastrointestinal stromal tumour 33.55 11.30 30 147114 954 34808833
Clostridium difficile infection 33.35 11.30 19 147125 18879 34790908
Disturbance in attention 33.28 11.30 36 147108 25909 34783878
Bladder cancer stage 0, with cancer in situ 33.17 11.30 11 147133 37 34809750
Nasopharyngeal cancer 33.15 11.30 15 147129 135 34809652
Drug-induced liver injury 32.74 11.30 44 147100 28788 34780999
Spinal cord neoplasm 32.50 11.30 16 147128 177 34809610
Staphylococcal infection 32.37 11.30 55 147089 32705 34777082
Neutrophil count decreased 32.05 11.30 109 147035 50995 34758792
Blood bilirubin increased 32.01 11.30 71 147073 38225 34771562
Neurotoxicity 31.94 11.30 18 147126 17992 34791795
Tongue cancer metastatic 31.32 11.30 7 147137 0 34809787
Rectal cancer stage II 31.32 11.30 7 147137 0 34809787
Bile duct cancer stage IV 31.32 11.30 7 147137 0 34809787
Cardiac disorder 31.31 11.30 86 147058 43040 34766747
Mitral valve incompetence 31.03 11.30 12 147132 14931 34794856
Sedation 30.61 11.30 26 147118 20980 34788807
Aspergillus infection 30.61 11.30 7 147137 12247 34797540
Hepatocellular injury 30.56 11.30 29 147115 22182 34787605
Intentional self-injury 30.40 11.30 10 147134 13761 34796026
Dysarthria 30.31 11.30 63 147081 34719 34775068
Blood pressure fluctuation 30.26 11.30 37 147107 25212 34784575
Myocarditis 30.09 11.30 10 147134 13672 34796115
Disease recurrence 29.64 11.30 28 147116 21462 34788325
Cytomegalovirus infection 29.56 11.30 40 147104 26095 34783692
Inflammation 29.36 11.30 46 147098 28249 34781538
Diabetic ketoacidosis 29.24 11.30 20 147124 18012 34791775
Depressed level of consciousness 29.22 11.30 88 147056 42753 34767034
Adverse event 29.22 11.30 22 147122 18855 34790932
Pathogen resistance 29.15 11.30 3 147141 9479 34800308
Abdominal discomfort 29.11 11.30 141 147003 59694 34750093
Bladder mass 28.96 11.30 16 147128 228 34809559
Heart rate decreased 28.94 11.30 56 147088 31689 34778098
Chronic lymphocytic leukaemia stage 1 28.84 11.30 7 147137 3 34809784
Colitis 28.37 11.30 74 147070 37676 34772111
Coronary artery disease 28.32 11.30 106 147038 48199 34761588
Disseminated intravascular coagulation 28.28 11.30 30 147114 21786 34788001
Epidural lipomatosis 28.02 11.30 28 147116 1026 34808761
Nasopharyngitis 27.95 11.30 176 146968 69792 34739995
Blood pressure increased 27.80 11.30 237 146907 87865 34721922
Cholestasis 27.78 11.30 44 147100 26904 34782883
Respiratory arrest 27.78 11.30 47 147097 27996 34781791
Hallucination 27.65 11.30 117 147027 51381 34758406
Mobility decreased 27.60 11.30 53 147091 30075 34779712
Shock haemorrhagic 27.35 11.30 7 147137 11347 34798440
Hospitalisation 27.15 11.30 135 147009 56767 34753020
Dry skin 26.98 11.30 57 147087 31230 34778557
Laryngeal cancer stage II 26.85 11.30 6 147138 0 34809787
Epiglottic cancer 26.85 11.30 6 147138 0 34809787
Dyspnoea exertional 26.67 11.30 93 147051 43186 34766601
Bone marrow failure 26.33 11.30 52 147092 29201 34780586
Drug eruption 26.20 11.30 27 147117 19871 34789916
Skin ulcer 26.15 11.30 33 147111 22183 34787604
Diabetes mellitus 26.10 11.30 105 147039 46768 34763019
No adverse event 26.02 11.30 35 147109 22892 34786895
Oesophageal polyp 25.82 11.30 10 147134 58 34809729
Pericardial effusion 25.68 11.30 40 147104 24622 34785165
Sarcoma 25.62 11.30 18 147126 400 34809387
Toxic skin eruption 25.61 11.30 8 147136 11377 34798410
Myelodysplastic syndrome 25.37 11.30 26 147118 19182 34790605
Bronchitis 25.31 11.30 91 147053 41872 34767915
Haemoptysis 25.27 11.30 70 147074 34936 34774851
Ejection fraction decreased 25.21 11.30 26 147118 19128 34790659
Poisoning 25.09 11.30 10 147134 12216 34797571
Blood alkaline phosphatase increased 25.08 11.30 59 147085 31116 34778671
Osteoarthritis 25.00 11.30 30 147114 20612 34789175
Cognitive disorder 24.97 11.30 52 147092 28641 34781146
Drug withdrawal syndrome 24.91 11.30 28 147116 19806 34789981
Dysphagia 24.87 11.30 157 146987 62224 34747563
Agitation 24.71 11.30 141 147003 57258 34752529
Gamma-glutamyltransferase increased 24.59 11.30 54 147090 29177 34780610
Lymphocyte percentage decreased 24.39 11.30 37 147107 2095 34807692
Generalised tonic-clonic seizure 24.36 11.30 32 147112 21142 34788645
Neuralgia 24.19 11.30 17 147127 15096 34794691
Infusion related reaction 24.12 11.30 128 147016 52929 34756858
Nasal sinus cancer 24.10 11.30 8 147136 27 34809760
Aphasia 24.10 11.30 33 147111 21421 34788366
Amnesia 24.09 11.30 47 147097 26516 34783271
Sleep disorder 23.90 11.30 62 147082 31626 34778161
Therapy interrupted 23.85 11.30 14 147130 13683 34796104
Acute myeloid leukaemia 23.82 11.30 25 147119 18245 34791542
Tongue neoplasm 23.67 11.30 8 147136 29 34809758
Cytopenia 23.61 11.30 12 147132 12711 34797076
Pneumocystis jirovecii pneumonia 23.49 11.30 29 147115 19681 34790106
Angina pectoris 23.17 11.30 62 147082 31301 34778486
Serotonin syndrome 23.06 11.30 30 147114 19903 34789884
Localised infection 23.00 11.30 24 147120 17563 34792224
Tachycardia 22.90 11.30 237 146907 84535 34725252
Crystal urine present 22.90 11.30 18 147126 477 34809310
Oroantral fistula 22.83 11.30 13 147131 197 34809590
Obstructive airways disorder 22.79 11.30 19 147125 15475 34794312
Nasopharyngeal cancer stage IV 22.72 11.30 6 147138 6 34809781
Agranulocytosis 22.62 11.30 41 147103 23780 34786007
Metastatic carcinoma of the bladder 22.44 11.30 13 147131 204 34809583
Malignant melanoma stage III 22.37 11.30 5 147139 0 34809787
Head and neck cancer stage III 22.37 11.30 5 147139 0 34809787
Anal cancer stage III 22.37 11.30 5 147139 0 34809787
Bile duct cancer stage III 22.37 11.30 5 147139 0 34809787
Swelling 22.29 11.30 97 147047 42269 34767518
Epilepsy 22.25 11.30 35 147109 21460 34788327
Electrocardiogram QT prolonged 22.01 11.30 93 147051 40859 34768928
Haematotoxicity 21.88 11.30 4 147140 8190 34801597
Tricuspid valve incompetence 21.70 11.30 7 147137 9753 34800034
Fungal infection 21.70 11.30 21 147123 15914 34793873
Full blood count abnormal 21.70 11.30 28 147116 18640 34791147
Bile duct cancer 21.62 11.30 20 147124 665 34809122
Bronchopulmonary aspergillosis 21.54 11.30 18 147126 14641 34795146
Glomerular filtration rate decreased 21.52 11.30 14 147130 12947 34796840
Road traffic accident 21.52 11.30 25 147119 17425 34792362
Pallor 21.49 11.30 47 147097 25433 34784354
Respiratory tract infection 21.46 11.30 31 147113 19681 34790106
Red blood cell sedimentation rate increased 21.41 11.30 6 147138 9156 34800631
Atrioventricular block 21.39 11.30 4 147140 8059 34801728
Laboratory test abnormal 21.30 11.30 33 147111 20358 34789429
Therapy partial responder 21.20 11.30 7 147137 9609 34800178
Graft versus host disease 21.11 11.30 9 147135 10560 34799227
Lung disorder 21.08 11.30 75 147069 34621 34775166
Paraesthesia 20.97 11.30 171 146973 64001 34745786
Adrenal insufficiency 20.94 11.30 17 147127 14030 34795757
Miosis 20.92 11.30 7 147137 9528 34800259
Haemolytic anaemia 20.81 11.30 9 147135 10470 34799317
Stomatitis 20.78 11.30 100 147044 42414 34767373
Tinnitus 20.59 11.30 33 147111 20085 34789702
Lymphopenia 20.58 11.30 23 147121 16312 34793475
Contusion 20.53 11.30 81 147063 36283 34773504
Injection site erythema 20.46 11.30 22 147122 15877 34793910
Subdural haematoma 20.43 11.30 34 147110 20387 34789400
Pericarditis 20.14 11.30 12 147132 11633 34798154
Drug level increased 20.12 11.30 39 147105 22057 34787730
Injection site haemorrhage 20.02 11.30 8 147136 9760 34800027
Unresponsive to stimuli 19.99 11.30 55 147089 27514 34782273
Disorientation 19.99 11.30 72 147072 33116 34776671
Psychotic disorder 19.89 11.30 46 147098 24406 34785381
Neutrophil percentage increased 19.83 11.30 31 147113 1802 34807985
Acute hepatic failure 19.81 11.30 18 147126 14056 34795731
Renal cancer recurrent 19.79 11.30 7 147137 30 34809757
Pneumonia aspiration 19.65 11.30 100 147044 41803 34767984
Cutaneous lupus erythematosus 19.64 11.30 20 147124 750 34809037
Parkinsonism 19.64 11.30 5 147139 8133 34801654
Sudden death 19.60 11.30 21 147123 15180 34794607
Hyperthermia 19.59 11.30 10 147134 10567 34799220
Head and neck cancer 19.56 11.30 15 147129 383 34809404
Product administration error 19.53 11.30 24 147120 16320 34793467
Depressed mood 19.48 11.30 32 147112 19285 34790502
Pneumopericardium 19.46 11.30 10 147134 122 34809665
Myasthenia gravis 19.39 11.30 3 147141 6937 34802850
Diverticulitis 19.38 11.30 34 147110 19970 34789817
Acute respiratory failure 19.37 11.30 66 147078 30862 34778925
Pulmonary alveolar haemorrhage 19.35 11.30 4 147140 7508 34802279
Dyslipidaemia 19.27 11.30 4 147140 7484 34802303
Diabetes mellitus inadequate control 19.21 11.30 17 147127 13447 34796340
Sinus tachycardia 19.20 11.30 27 147117 17333 34792454
Delusion of grandeur 19.10 11.30 24 147120 1136 34808651
Joint stiffness 19.09 11.30 11 147133 10862 34798925
Device malfunction 19.08 11.30 10 147134 10411 34799376
Malignant melanoma 19.07 11.30 76 147068 8014 34801773
Juvenile idiopathic arthritis 19.04 11.30 31 147113 1866 34807921
Lymphadenopathy 19.03 11.30 59 147085 28404 34781383
Breast cancer 19.01 11.30 13 147131 276 34809511
Visual acuity reduced 19.00 11.30 24 147120 16125 34793662
Pulmonary hypertension 19.00 11.30 37 147107 20887 34788900
Haematuria 18.94 11.30 128 147016 49938 34759849
International normalised ratio increased 18.92 11.30 119 147025 47208 34762579
Tooth deposit 18.81 11.30 9 147135 93 34809694
Carcinoid tumour 18.80 11.30 12 147132 226 34809561
Oliguria 18.65 11.30 6 147138 8374 34801413
Hyperglycaemia 18.64 11.30 94 147050 39386 34770401
Prostate cancer recurrent 18.36 11.30 22 147122 991 34808796
Restlessness 18.36 11.30 51 147093 25431 34784356
Illness 18.22 11.30 18 147126 13511 34796276
Specific gravity urine increased 18.19 11.30 10 147134 141 34809646
Drug level fluctuating 18.15 11.30 16 147128 499 34809288
Ventricular fibrillation 18.02 11.30 44 147100 22910 34786877
Oesophageal pain 18.02 11.30 20 147124 829 34808958
Subarachnoid haemorrhage 17.97 11.30 16 147128 12619 34797168
Acute respiratory distress syndrome 17.96 11.30 53 147091 25916 34783871
Urinary retention 17.94 11.30 85 147059 36203 34773584
Tendonitis 17.91 11.30 8 147136 9132 34800655
Small intestine carcinoma stage 0 17.90 11.30 4 147140 0 34809787
Nasopharyngeal cancer stage III 17.90 11.30 4 147140 0 34809787
Colon cancer stage 0 17.90 11.30 4 147140 0 34809787
Bile duct cancer stage II 17.90 11.30 4 147140 0 34809787
Gallbladder cancer stage 0 17.90 11.30 4 147140 0 34809787
Anal cancer stage II 17.90 11.30 4 147140 0 34809787
Ovarian cancer 17.90 11.30 4 147140 0 34809787
Malignant splenic neoplasm 17.90 11.30 4 147140 0 34809787
Gallbladder cancer stage II 17.90 11.30 4 147140 0 34809787
Influenza 17.80 11.30 129 147015 49537 34760250
Haemophagocytic lymphohistiocytosis 17.77 11.30 17 147127 12956 34796831
Cardiomyopathy 17.75 11.30 27 147117 16781 34793006
Akathisia 17.71 11.30 6 147138 8103 34801684
Vasculitis 17.69 11.30 13 147131 11283 34798504
Discomfort 17.62 11.30 33 147111 18905 34790882
Prostatomegaly 17.59 11.30 56 147088 5285 34804502
Anal cancer 17.56 11.30 15 147129 448 34809339
Lymphoproliferative disorder 17.49 11.30 37 147107 2722 34807065
Adverse drug reaction 17.45 11.30 64 147080 29278 34780509
Haemorrhage intracranial 17.44 11.30 25 147119 15921 34793866
Melaena 17.42 11.30 83 147061 35297 34774490
Bundle branch block right 17.42 11.30 5 147139 7511 34802276
Product quality issue 17.38 11.30 28 147116 17007 34792780
Gingival atrophy 17.35 11.30 7 147137 46 34809741
Prescribed underdose 17.22 11.30 8 147136 8925 34800862
Venoocclusive liver disease 17.21 11.30 6 147138 7960 34801827
Atrial septal defect 16.98 11.30 5 147139 7387 34802400
Progressive multifocal leukoencephalopathy 16.97 11.30 10 147134 9754 34800033
Prostatic dysplasia 16.92 11.30 5 147139 10 34809777
Clostridium difficile colitis 16.87 11.30 25 147119 15705 34794082
Nephrolithiasis 16.85 11.30 68 147076 30265 34779522
Labelled drug-drug interaction medication error 16.76 11.30 23 147121 14916 34794871
Dysstasia 16.69 11.30 16 147128 12179 34797608
Immune reconstitution inflammatory syndrome 16.65 11.30 8 147136 8751 34801036
Sinusitis 16.60 11.30 104 147040 41298 34768489
Liver injury 16.59 11.30 23 147121 14855 34794932
Child abuse 16.54 11.30 14 147130 413 34809374
Cardiogenic shock 16.53 11.30 57 147087 26561 34783226
Blood uric acid increased 16.52 11.30 10 147134 9614 34800173
Medication error 16.39 11.30 54 147090 25511 34784276
Renal cell carcinoma stage III 16.31 11.30 5 147139 12 34809775
Benign neoplasm of bladder 16.31 11.30 5 147139 12 34809775
Hepatic steatosis 16.21 11.30 33 147111 18329 34791458
Productive cough 16.21 11.30 93 147051 37720 34772067
Osteomyelitis 16.02 11.30 27 147117 16109 34793678
Mental impairment 16.01 11.30 12 147132 10310 34799477
Transient ischaemic attack 15.91 11.30 61 147083 27552 34782235
Monocyte percentage increased 15.88 11.30 20 147124 949 34808838
Abdominal pain upper 15.77 11.30 209 146935 71281 34738506
Blood pressure systolic increased 15.75 11.30 47 147097 22905 34786882
Prescribed overdose 15.73 11.30 13 147131 10634 34799153
Head injury 15.73 11.30 33 147111 18127 34791660
Delusion 15.69 11.30 18 147126 12617 34797170
Underdose 15.67 11.30 21 147123 13759 34796028
Rectal cancer stage IV 15.67 11.30 4 147140 3 34809784
Leukopenia 15.66 11.30 179 146965 62677 34747110
Tumour lysis syndrome 15.63 11.30 30 147114 17029 34792758
Dementia 15.59 11.30 21 147123 13727 34796060
Aspiration 15.55 11.30 17 147127 12177 34797610
Gastric cancer recurrent 15.51 11.30 5 147139 15 34809772
Hemiplegia 15.50 11.30 5 147139 6967 34802820
Glycosylated haemoglobin increased 15.43 11.30 15 147129 11345 34798442
Nightmare 15.31 11.30 23 147121 14368 34795419
Right ventricular failure 15.26 11.30 9 147135 8775 34801012
Proteinuria 15.22 11.30 35 147109 18607 34791180
Rectal haemorrhage 15.18 11.30 103 147041 40146 34769641
Orthostatic hypotension 15.10 11.30 57 147087 25862 34783925
Total lung capacity abnormal 15.06 11.30 9 147135 150 34809637
Splenic neoplasm malignancy unspecified 15.04 11.30 5 147139 17 34809770
Ill-defined disorder 15.02 11.30 22 147122 13887 34795900
Upper respiratory tract infection 14.88 11.30 80 147064 32979 34776808
Peritonitis 14.80 11.30 29 147115 16336 34793451
Dry mouth 14.71 11.30 71 147073 30094 34779693
Pneumonitis 14.69 11.30 83 147061 33795 34775992
Injection site reaction 14.68 11.30 20 147124 13013 34796774
Irritability 14.58 11.30 54 147090 24636 34785151
Thrombotic microangiopathy 14.48 11.30 14 147130 10616 34799171
Treatment noncompliance 14.38 11.30 65 147079 28035 34781752
Splenomegaly 14.37 11.30 26 147118 15091 34794696
Exposure during pregnancy 14.36 11.30 10 147134 8924 34800863
Haematopoietic stem cell mobilisation 14.36 11.30 9 147135 164 34809623
Skin lesion 14.34 11.30 46 147098 21915 34787872
Nasal neoplasm 14.30 11.30 8 147136 117 34809670
Chronic leukaemia 14.26 11.30 4 147140 6 34809781
Muscle rigidity 14.16 11.30 14 147130 10504 34799283
Withdrawal syndrome 14.15 11.30 19 147125 12436 34797351
Uveitis 14.14 11.30 7 147137 7528 34802259
Paranoia 14.13 11.30 18 147126 12050 34797737
Mental status changes 14.09 11.30 98 147046 37985 34771802
Urine abnormality 14.08 11.30 28 147116 1971 34807816
Fear 14.04 11.30 14 147130 10462 34799325
Lip neoplasm malignant stage unspecified 14.03 11.30 5 147139 22 34809765
Impaired healing 14.02 11.30 27 147117 15307 34794480
Delirium 14.02 11.30 118 147026 43873 34765914
Airway remodelling 13.97 11.30 10 147134 229 34809558
Dystonia 13.96 11.30 15 147129 10830 34798957
Full blood count decreased 13.94 11.30 35 147109 18053 34791734
Psychomotor hyperactivity 13.91 11.30 12 147132 9610 34800177
Ventricular tachycardia 13.89 11.30 61 147083 26518 34783269
Pulmonary fibrosis 13.87 11.30 36 147108 18360 34791427
Arteriosclerosis 13.86 11.30 18 147126 11950 34797837
Knee arthroplasty 13.84 11.30 7 147137 7437 34802350
Hypercholesterolaemia 13.83 11.30 10 147134 8752 34801035
Second primary malignancy 13.81 11.30 8 147136 7878 34801909
Blood lactate dehydrogenase increased 13.76 11.30 50 147094 22940 34786847
Mucormycosis 13.68 11.30 4 147140 5938 34803849
Paraneoplastic rash 13.51 11.30 7 147137 87 34809700
Hypercalcaemia 13.49 11.30 28 147116 15440 34794347
Hyperbilirubinaemia 13.45 11.30 32 147112 16811 34792976
Urine leukocyte esterase positive 13.43 11.30 13 147131 458 34809329
Prostatic atrophy 13.42 11.30 3 147141 0 34809787
Salivary gland cancer stage I 13.42 11.30 3 147141 0 34809787
Bile duct cancer stage I 13.42 11.30 3 147141 0 34809787
Oesophageal adenocarcinoma stage IV 13.42 11.30 3 147141 0 34809787
Metastases to prostate 13.42 11.30 3 147141 0 34809787
Oropharyngeal cancer stage IV 13.42 11.30 3 147141 0 34809787
B-cell lymphoma stage III 13.42 11.30 3 147141 0 34809787
Head and neck cancer stage I 13.42 11.30 3 147141 0 34809787
Follicular lymphoma stage III 13.42 11.30 3 147141 0 34809787
Myoclonus 13.40 11.30 26 147118 14699 34795088
Staphylococcal sepsis 13.37 11.30 13 147131 9831 34799956
Malignant neoplasm of ampulla of Vater 13.22 11.30 4 147140 9 34809778
Therapeutic response unexpected 13.12 11.30 13 147131 9744 34800043
Oxygen saturation decreased 13.12 11.30 154 146990 53664 34756123
Rhinalgia 13.09 11.30 19 147125 1034 34808753
Multiple-drug resistance 13.07 11.30 3 147141 5236 34804551
Bone pain 13.05 11.30 44 147100 20642 34789145
Pancreatitis 12.99 11.30 103 147041 38788 34770999
Precancerous condition 12.98 11.30 6 147138 57 34809730
Oropharyngeal cancer 12.98 11.30 6 147138 57 34809730
Inappropriate antidiuretic hormone secretion 12.98 11.30 21 147123 12732 34797055
Therapy cessation 12.96 11.30 33 147111 16940 34792847
Surgery 12.88 11.30 25 147119 14132 34795655
Malnutrition 12.86 11.30 21 147123 12688 34797099
White blood cells urine positive 12.81 11.30 21 147123 1271 34808516
Brain neoplasm 12.80 11.30 36 147108 3173 34806614
Rash maculo-papular 12.72 11.30 69 147075 28382 34781405
Rib fracture 12.61 11.30 26 147118 14374 34795413
Dyskinesia 12.60 11.30 50 147094 22363 34787424
Nervousness 12.60 11.30 21 147123 12585 34797202
Palmar-plantar erythrodysaesthesia syndrome 12.56 11.30 33 147111 16762 34793025
Pulmonary arterial hypertension 12.51 11.30 11 147133 8728 34801059
Stent placement 12.49 11.30 3 147141 5075 34804712
Abscess 12.46 11.30 19 147125 11798 34797989
Hepatic encephalopathy 12.45 11.30 27 147117 14658 34795129
Circulatory collapse 12.43 11.30 46 147098 20992 34788795
Cardiac failure chronic 12.43 11.30 9 147135 7870 34801917
Band neutrophil percentage increased 12.42 11.30 7 147137 104 34809683
Hypervolaemia 12.38 11.30 42 147102 19667 34790120
Colorectal cancer recurrent 12.37 11.30 5 147139 33 34809754
Hypophosphataemia 12.34 11.30 17 147127 11009 34798778
Blood urea increased 12.31 11.30 76 147068 30288 34779499
Infective pulmonary exacerbation of cystic fibrosis 12.30 11.30 59 147085 6742 34803045
Bacterial test 12.29 11.30 8 147136 156 34809631
Photophobia 12.29 11.30 7 147137 6957 34802830
Apathy 12.19 11.30 7 147137 6925 34802862
Ataxia 12.14 11.30 25 147119 13828 34795959
Central nervous system lesion 12.14 11.30 6 147138 6457 34803330
Osteonecrosis 12.12 11.30 28 147116 14862 34794925
Lymphocytic infiltration 12.10 11.30 15 147129 700 34809087
Optic discs blurred 12.06 11.30 6 147138 68 34809719
Angina unstable 12.03 11.30 19 147125 11634 34798153
Hypogammaglobulinaemia 12.00 11.30 9 147135 7731 34802056
Left ventricular hypertrophy 11.92 11.30 10 147134 8120 34801667
Maternal exposure during pregnancy 11.91 11.30 3 147141 4915 34804872
Klebsiella infection 11.90 11.30 11 147133 8520 34801267
Product storage error 11.90 11.30 10 147134 8112 34801675
Pain in jaw 11.89 11.30 23 147121 13017 34796770
Asphyxia 11.88 11.30 7 147137 6828 34802959
Gait inability 11.87 11.30 46 147098 20712 34789075
Neoplasm progression 11.86 11.30 54 147090 23246 34786541
Kounis syndrome 11.81 11.30 30 147114 2488 34807299
Bladder transitional cell carcinoma 11.81 11.30 31 147113 2624 34807163
Gastrointestinal disorder 11.77 11.30 89 147055 33859 34775928
Hypokinesia 11.75 11.30 12 147132 8868 34800919
Intraocular pressure increased 11.72 11.30 4 147140 5379 34804408
Foetal hypokinesia 11.71 11.30 11 147133 373 34809414
Mucosal inflammation 11.68 11.30 105 147039 38517 34771270
Hyperuricaemia 11.66 11.30 10 147134 8033 34801754
Pneumonia bacterial 11.66 11.30 20 147124 11852 34797935
Anaphylactic reaction 11.66 11.30 196 146948 32105 34777682
Speech disorder 11.65 11.30 62 147082 25624 34784163
Eosinophil percentage increased 11.63 11.30 13 147131 543 34809244
Abnormal dreams 11.51 11.30 9 147135 7569 34802218
Limb discomfort 11.42 11.30 18 147126 11029 34798758
Hepatotoxicity 11.41 11.30 49 147095 21436 34788351
Eye disorder 11.37 11.30 14 147130 9514 34800273
Hypocalcaemia 11.37 11.30 58 147086 24231 34785556
Malignant neoplasm of thorax 11.36 11.30 3 147141 3 34809784
Pneumonia fungal 11.34 11.30 8 147136 7092 34802695
Osteonecrosis of jaw 11.32 11.30 38 147106 17851 34791936
Gastric haemorrhage 11.31 11.30 16 147128 10245 34799542

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Prostate cancer 44349.00 10.22 12532 318163 20736 79392957
Bladder cancer 34978.98 10.22 9290 321405 10236 79403457
Oesophageal carcinoma 28350.64 10.22 7010 323685 4074 79409619
Colorectal cancer 27441.06 10.22 6508 324187 2139 79411554
Breast cancer stage I 26175.93 10.22 5971 324724 729 79412964
Breast cancer female 25150.44 10.22 6413 324282 5048 79408645
Renal cancer 24443.04 10.22 6352 324343 5874 79407819
Breast cancer stage II 19943.28 10.22 4974 325721 3146 79410547
Colorectal cancer stage III 14766.91 10.22 3288 327407 11 79413682
Colorectal cancer stage IV 13577.27 10.22 3026 327669 22 79413671
Gastric cancer 12169.02 10.22 3533 327162 6646 79407047
Prostate cancer stage I 11225.79 10.22 2516 328179 81 79413612
Hepatic cancer stage IV 11164.47 10.22 2490 328205 24 79413669
Hepatic cancer 10240.45 10.22 3116 327579 7413 79406280
Prostate cancer stage IV 10081.69 10.22 2274 328421 140 79413553
Breast cancer stage III 9223.53 10.22 2830 327865 6996 79406697
Prostate cancer stage II 9057.96 10.22 2053 328642 173 79413520
Pancreatic carcinoma stage IV 9051.30 10.22 2047 328648 151 79413542
Colorectal cancer stage II 8337.75 10.22 1856 328839 0 79413693
Prostate cancer stage III 7867.04 10.22 1757 328938 26 79413667
Pancreatic carcinoma 7522.94 10.22 2624 328071 10953 79402740
Breast cancer stage IV 7264.09 10.22 1676 329019 288 79413405
Renal cancer stage IV 7221.55 10.22 1622 329073 66 79413627
Renal cancer stage I 6926.17 10.22 1547 329148 23 79413670
Gastric cancer stage IV 6492.60 10.22 1457 329238 53 79413640
Colorectal cancer stage I 5960.25 10.22 1327 329368 0 79413693
Lung carcinoma cell type unspecified stage IV 5947.59 10.22 1443 329252 650 79413043
Gastrointestinal carcinoma 5142.48 10.22 1410 329285 1889 79411804
Bladder cancer stage II 4990.77 10.22 1113 329582 8 79413685
Bladder cancer stage IV 4982.77 10.22 1111 329584 7 79413686
Renal cancer stage II 4890.88 10.22 1089 329606 0 79413693
Renal cancer stage III 4829.58 10.22 1078 329617 12 79413681
Lung neoplasm malignant 4107.90 10.22 2097 328598 25695 79387998
Uterine cancer 3886.33 10.22 1162 329533 2529 79411164
Bladder cancer stage III 3704.89 10.22 825 329870 0 79413693
Gastric cancer stage I 3659.97 10.22 815 329880 0 79413693
Testis cancer 3278.05 10.22 802 329893 401 79413292
Thyroid cancer 3244.58 10.22 1119 329576 4469 79409224
Skin cancer 2758.53 10.22 1315 329380 13725 79399968
Gastric cancer stage III 2541.26 10.22 569 330126 14 79413679
Gastric cancer stage II 2465.21 10.22 549 330146 0 79413693
Haematological malignancy 2390.47 10.22 591 330104 334 79413359
Brain neoplasm malignant 2154.05 10.22 619 330076 1094 79412599
Pancreatic carcinoma stage III 2138.87 10.22 477 330218 3 79413690
Neoplasm malignant 2124.50 10.22 1435 329260 30375 79383318
Pancreatic carcinoma stage II 2096.94 10.22 467 330228 0 79413693
Lung carcinoma cell type unspecified stage I 2032.63 10.22 470 330225 85 79413608
Prostate cancer stage 0 1769.11 10.22 394 330301 0 79413693
Lung carcinoma cell type unspecified stage III 1680.41 10.22 394 330301 100 79413593
Throat cancer 1628.27 10.22 487 330208 1060 79412633
Pancreatic carcinoma stage I 1523.64 10.22 340 330355 3 79413690
Hepatic cancer stage III 1495.18 10.22 333 330362 0 79413693
Disease progression 1409.01 10.22 2646 328049 181716 79231977
Hepatic cancer stage I 1293.11 10.22 288 330407 0 79413693
Hepatic cancer stage II 1279.64 10.22 285 330410 0 79413693
Breast cancer 1200.29 10.22 1047 329648 32734 79380959
Lung carcinoma cell type unspecified stage II 1176.80 10.22 269 330426 33 79413660
Thyroid cancer stage I 1176.36 10.22 262 330433 0 79413693
Drug ineffective 1152.94 10.22 1693 329002 1079220 78334473
Bone cancer 1094.95 10.22 384 330311 1628 79412065
Ovarian cancer 922.00 10.22 408 330287 3526 79410167
Appendix cancer 839.88 10.22 202 330493 80 79413613
Toxicity to various agents 775.85 10.22 390 330305 421150 78992543
Small intestine carcinoma 737.93 10.22 242 330453 794 79412899
Off label use 737.62 10.22 1676 329019 905539 78508154
Completed suicide 624.75 10.22 129 330566 245638 79168055
Thyroid cancer stage II 624.07 10.22 139 330556 0 79413693
Thyroid cancer stage IV 616.63 10.22 138 330557 3 79413690
Death 609.45 10.22 879 329816 565635 78848058
Ovarian cancer stage IV 598.39 10.22 147 330548 77 79413616
Small intestine carcinoma stage IV 561.22 10.22 125 330570 0 79413693
Bladder cancer stage I, with cancer in situ 525.30 10.22 117 330578 0 79413693
Ovarian cancer stage I 520.81 10.22 116 330579 0 79413693
Breast cancer male 503.44 10.22 139 330556 194 79413499
Synovitis 475.64 10.22 40 330655 150694 79262999
Thyroid cancer stage III 453.46 10.22 101 330594 0 79413693
Cervix carcinoma 453.02 10.22 210 330485 2043 79411650
Condition aggravated 429.62 10.22 897 329798 500227 78913466
Colon cancer stage IV 409.55 10.22 123 330572 273 79413420
Gallbladder cancer 406.46 10.22 134 330561 449 79413244
Prostatic disorder 405.49 10.22 192 330503 1968 79411725
Drug abuse 393.95 10.22 95 330600 162596 79251097
Arthropathy 385.15 10.22 127 330568 176984 79236709
Fall 383.43 10.22 915 329780 486714 78926979
Gastric cancer stage 0 382.16 10.22 88 330607 14 79413679
Pemphigus 377.67 10.22 7 330688 99575 79314118
Colon cancer 363.89 10.22 371 330324 14152 79399541
Colorectal carcinoma stage 0 359.17 10.22 80 330615 0 79413693
Joint swelling 356.23 10.22 403 330292 288243 79125450
Lymphoma 342.64 10.22 392 330303 17068 79396625
Acute kidney injury 337.11 10.22 1070 329625 518334 78895359
Systemic lupus erythematosus 335.04 10.22 51 330644 121098 79292595
Ovarian cancer stage III 333.52 10.22 96 330599 171 79413522
Drug interaction 332.69 10.22 771 329924 414412 78999281
Pericarditis 330.63 10.22 27 330668 104209 79309484
Thyroid cancer stage 0 323.25 10.22 72 330623 0 79413693
Gallbladder cancer stage IV 305.30 10.22 68 330627 0 79413693
General physical health deterioration 304.30 10.22 418 330277 274820 79138873
Pneumonia 301.98 10.22 1561 329134 658685 78755008
Anaemia 299.81 10.22 901 329794 444114 78969579
Colon cancer stage III 299.60 10.22 92 330603 227 79413466
Treatment failure 296.57 10.22 169 330526 170317 79243376
Ovarian cancer stage II 295.08 10.22 67 330628 6 79413687
Anti-cyclic citrullinated peptide antibody positive 292.66 10.22 12 330683 83131 79330562
Arthralgia 290.41 10.22 1302 329393 570501 78843192
Diarrhoea 283.24 10.22 2317 328378 878172 78535521
Nasal cavity cancer 281.82 10.22 83 330612 167 79413526
Drug intolerance 281.16 10.22 412 330283 263707 79149986
Glossodynia 273.49 10.22 49 330646 103288 79310405
Hand deformity 267.09 10.22 53 330642 103866 79309827
Wound 256.60 10.22 81 330614 116098 79297595
Colon cancer stage II 251.77 10.22 70 330625 102 79413591
Cervix carcinoma stage I 250.23 10.22 57 330638 6 79413687
Alopecia 235.49 10.22 372 330323 230983 79182710
Colon cancer stage I 234.37 10.22 61 330634 56 79413637
Small intestine carcinoma stage III 233.46 10.22 52 330643 0 79413693
Product use in unapproved indication 231.52 10.22 428 330267 249931 79163762
Pyrexia 230.42 10.22 1759 328936 676950 78736743
Rheumatoid factor positive 227.73 10.22 4 330691 59835 79353858
Fatigue 227.62 10.22 2615 328080 927112 78486581
Intentional product use issue 226.64 10.22 179 330516 151933 79261760
Pain 225.98 10.22 1852 328843 701950 78711743
Infection 215.80 10.22 422 330273 241290 79172403
Leukaemia 215.11 10.22 186 330509 5739 79407954
Therapeutic product effect incomplete 213.16 10.22 165 330530 141480 79272213
Swelling 212.55 10.22 357 330338 216354 79197339
Duodenal ulcer perforation 210.38 10.22 17 330678 66194 79347499
Loss of personal independence in daily activities 205.31 10.22 84 330611 102496 79311197
Weight increased 203.27 10.22 539 330156 276847 79136846
Lung carcinoma cell type unspecified stage 0 195.34 10.22 51 330644 48 79413645
Therapeutic product effect decreased 195.30 10.22 235 330460 163628 79250065
Helicobacter infection 193.48 10.22 29 330666 69675 79344018
Multiple organ dysfunction syndrome 192.75 10.22 131 330564 120115 79293578
Intentional overdose 190.08 10.22 101 330594 105859 79307834
Cervix carcinoma stage IV 189.94 10.22 48 330647 34 79413659
Asthenia 189.48 10.22 1293 329402 510396 78903297
Food allergy 189.11 10.22 229 330466 10595 79403098
Small intestine carcinoma stage II 188.56 10.22 42 330653 0 79413693
Sepsis 187.37 10.22 537 330158 268891 79144802
Anhedonia 184.18 10.22 266 330429 14632 79399061
Pancytopenia 183.77 10.22 251 330444 165494 79248199
Cervix carcinoma stage II 183.55 10.22 45 330650 23 79413670
Cardiac failure 181.43 10.22 225 330470 154617 79259076
Tongue carcinoma stage IV 179.58 10.22 40 330655 0 79413693
Maternal exposure during pregnancy 177.87 10.22 182 330513 136356 79277337
Abdominal discomfort 177.08 10.22 496 330199 250231 79163462
Overdose 174.63 10.22 310 330385 183896 79229797
Myocardial infarction 174.44 10.22 310 330385 183819 79229874
Temperature regulation disorder 173.63 10.22 164 330531 5689 79408004
Confusional state 171.55 10.22 707 329988 317290 79096403
Mobility decreased 170.64 10.22 153 330542 122022 79291671
Discomfort 169.90 10.22 162 330533 125455 79288238
Contraindicated product administered 169.25 10.22 244 330451 157294 79256399
Crystal urine present 167.37 10.22 107 330588 2053 79411640
Hypotension 166.25 10.22 1106 329589 439211 78974482
Small intestine carcinoma stage I 166.12 10.22 37 330658 0 79413693
Pancreatic carcinoma stage 0 166.12 10.22 37 330658 0 79413693
Adrenal gland cancer 164.99 10.22 47 330648 79 79413614
Incorrect dose administered 164.53 10.22 692 330003 75938 79337755
Psoriatic arthropathy 164.17 10.22 59 330636 77940 79335753
Tongue neoplasm malignant stage unspecified 163.52 10.22 83 330612 1001 79412692
Folliculitis 163.37 10.22 19 330676 55361 79358332
Nausea 160.52 10.22 2901 327794 954295 78459398
COVID-19 159.93 10.22 254 330441 157420 79256273
Urinary sediment present 158.80 10.22 110 330585 2425 79411268
Urine abnormality 158.68 10.22 183 330512 8036 79405657
Dyspnoea 158.66 10.22 2551 328144 854474 78559219
Infusion related reaction 158.50 10.22 461 330234 229776 79183917
Renal impairment 158.32 10.22 256 330439 157527 79256166
Cervix carcinoma stage III 155.77 10.22 37 330658 12 79413681
Sinusitis 155.55 10.22 364 330331 195137 79218556
C-reactive protein abnormal 154.83 10.22 12 330683 48355 79365338
Rash 154.56 10.22 1593 329102 576765 78836928
Suicide attempt 150.29 10.22 78 330617 82854 79330839
Impaired healing 149.38 10.22 89 330606 87566 79326127
Disability 148.55 10.22 260 330435 16860 79396833
Muscle injury 147.48 10.22 15 330680 48546 79365147
Peripheral swelling 145.65 10.22 599 330096 269018 79144675
Injection site pain 145.56 10.22 195 330500 129643 79284050
Product dose omission issue 145.22 10.22 532 330163 247005 79166688
Oesophageal carcinoma stage 0 143.67 10.22 32 330663 0 79413693
Oedema peripheral 142.93 10.22 550 330145 251738 79161955
Musculoskeletal stiffness 142.32 10.22 322 330373 174686 79239007
Thrombocytopenia 142.24 10.22 591 330104 264668 79149025
Neutropenia 141.59 10.22 662 330033 287048 79126645
Decreased appetite 141.08 10.22 837 329858 341581 79072112
Stomatitis 140.87 10.22 245 330450 146512 79267181
Malignant neoplasm progression 138.92 10.22 218 330477 135772 79277921
Respiratory failure 137.47 10.22 345 330350 180566 79233127
Hepatic enzyme increased 137.40 10.22 350 330345 182260 79231433
Septic shock 136.07 10.22 186 330509 122615 79291078
Product use issue 135.92 10.22 432 330263 209390 79204303
Rheumatoid arthritis 134.50 10.22 430 330265 208040 79205653
Nasopharyngitis 134.05 10.22 569 330126 253312 79160381
Drug resistance 133.66 10.22 11 330684 42202 79371491
Lactic acidosis 130.76 10.22 64 330631 70295 79343398
Lymphocyte percentage decreased 129.92 10.22 130 330565 4846 79408847
Vomiting 129.74 10.22 1962 328733 663866 78749827
Dizziness 128.97 10.22 1479 329216 524962 78888731
White blood cells urine positive 128.77 10.22 142 330553 5933 79407760
Urine leukocyte esterase positive 125.91 10.22 117 330578 3974 79409719
Atrial fibrillation 125.68 10.22 411 330284 197475 79216218
Therapy non-responder 124.86 10.22 119 330576 92186 79321507
Weight decreased 124.73 10.22 911 329784 354287 79059406
Brain cancer metastatic 124.33 10.22 47 330648 257 79413436
Adverse event 124.27 10.22 47 330648 60167 79353526
Neutrophil percentage increased 123.35 10.22 123 330572 4566 79409127
Cardiac failure congestive 121.56 10.22 255 330440 142147 79271546
Red blood cell sedimentation rate increased 118.93 10.22 23 330672 45919 79367774
Hepatic cancer metastatic 118.08 10.22 62 330633 806 79412887
Arthritis 117.49 10.22 184 330511 114696 79298997
Cerebrovascular accident 117.31 10.22 297 330398 154995 79258698
Laryngeal cancer stage I 116.73 10.22 26 330669 0 79413693
Tongue carcinoma stage III 116.73 10.22 26 330669 0 79413693
Irritable bowel syndrome 116.60 10.22 56 330639 62185 79351508
Rhabdomyolysis 116.49 10.22 154 330541 102977 79310716
Blister 115.98 10.22 198 330497 119278 79294415
Pain in extremity 115.36 10.22 962 329733 363576 79050117
Urine analysis abnormal 114.00 10.22 138 330557 6382 79407311
Febrile neutropenia 111.56 10.22 535 330160 230464 79183229
Lip and/or oral cavity cancer 111.54 10.22 65 330630 1048 79412645
Liver injury 110.63 10.22 48 330647 56566 79357127
Red blood cells urine positive 110.41 10.22 119 330576 4844 79408849
Cardio-respiratory arrest 107.01 10.22 178 330517 108332 79305361
Bone cancer metastatic 106.84 10.22 40 330655 212 79413481
Oedema 106.44 10.22 209 330486 119371 79294322
Lymphocyte count decreased 106.16 10.22 433 330262 46856 79366837
Hyperkalaemia 105.27 10.22 196 330499 114202 79299491
Pulmonary embolism 105.24 10.22 362 330333 171292 79242401
Knee arthroplasty 105.12 10.22 25 330670 43223 79370470
Dehydration 103.04 10.22 605 330090 247582 79166111
Depressed level of consciousness 101.52 10.22 152 330543 96500 79317193
Renal failure 101.44 10.22 458 330237 200510 79213183
Cardiac arrest 100.79 10.22 370 330325 171726 79241967
Rheumatic fever 100.76 10.22 4 330691 28521 79385172
Deep vein thrombosis 100.31 10.22 220 330475 120699 79292994
Hip arthroplasty 98.94 10.22 15 330680 35741 79377952
Tongue carcinoma stage II 98.77 10.22 22 330673 0 79413693
Tonsil cancer 98.37 10.22 61 330634 1107 79412586
Drug hypersensitivity 97.19 10.22 783 329912 298133 79115560
Intentional product misuse 95.81 10.22 154 330541 95011 79318682
Urinary tract infection 94.42 10.22 708 329987 273804 79139889
Gallbladder cancer stage I 94.28 10.22 21 330674 0 79413693
Urethral cancer 94.19 10.22 27 330668 47 79413646
Hepatic cytolysis 92.04 10.22 5 330690 27146 79386547
Hypoglycaemia 91.77 10.22 176 330519 101418 79312275
Coeliac disease 91.57 10.22 167 330528 11184 79402509
Therapeutic response decreased 90.63 10.22 86 330609 66767 79346926
Laryngeal cancer 90.44 10.22 50 330645 725 79412968
Gait disturbance 90.34 10.22 498 330197 207008 79206685
Encephalopathy 89.85 10.22 88 330607 67309 79346384
Gallbladder cancer stage II 89.79 10.22 20 330675 0 79413693
C-reactive protein increased 89.72 10.22 257 330438 128770 79284923
Metabolic acidosis 87.45 10.22 129 330566 82400 79331293
Myelosuppression 85.61 10.22 30 330665 40266 79373427
Syncope 85.23 10.22 418 330277 179031 79234662
Interstitial lung disease 84.52 10.22 216 330479 112384 79301309
Osteoarthritis 84.45 10.22 145 330550 87164 79326529
Chronic obstructive pulmonary disease 83.41 10.22 141 330554 85278 79328415
Gastrointestinal haemorrhage 82.34 10.22 324 330371 147395 79266298
Hyponatraemia 82.33 10.22 418 330277 177430 79236263
Gallbladder cancer stage III 80.81 10.22 18 330677 0 79413693
Drug-induced liver injury 80.68 10.22 93 330602 66024 79347669
Bacterial test 78.80 10.22 54 330641 1169 79412524
Bladder cancer recurrent 78.76 10.22 40 330655 483 79413210
Neuroendocrine carcinoma 78.67 10.22 42 330653 566 79413127
Drug eruption 78.59 10.22 42 330653 43893 79369800
Altered state of consciousness 78.23 10.22 42 330653 43780 79369913
Pleural effusion 78.20 10.22 323 330372 144939 79268754
Wrong technique in product usage process 77.76 10.22 116 330579 73759 79339934
Sedation 77.34 10.22 61 330634 51834 79361859
Immunodeficiency 77.29 10.22 232 330463 21536 79392157
Haematochezia 76.43 10.22 155 330540 87490 79326203
Sleep disorder 76.01 10.22 150 330545 85527 79328166
Hepatic function abnormal 75.78 10.22 116 330579 72991 79340702
COVID-19 pneumonia 75.62 10.22 14 330681 28835 79384858
Depression 75.06 10.22 558 330137 216232 79197461
Anaphylactic reaction 72.20 10.22 594 330101 83149 79330544
Anal cancer stage III 71.83 10.22 16 330679 0 79413693
Tongue carcinoma stage I 71.83 10.22 16 330679 0 79413693
Osteoporosis 71.73 10.22 71 330624 54041 79359652
Injection site reaction 71.35 10.22 73 330622 54712 79358981
Somnolence 70.93 10.22 641 330054 238340 79175353
Neuroleptic malignant syndrome 70.91 10.22 14 330681 27545 79386148
Flushing 70.76 10.22 616 330079 87652 79326041
Malaise 70.70 10.22 1521 329174 488348 78925345
Accidental exposure to product 70.64 10.22 21 330674 31301 79382392
Aspartate aminotransferase increased 69.31 10.22 317 330378 138324 79275369
Therapy interrupted 68.91 10.22 22 330673 31319 79382374
Cervix carcinoma stage 0 68.09 10.22 29 330666 226 79413467
Blood glucose increased 68.08 10.22 246 330449 114729 79298964
Monocyte percentage increased 67.38 10.22 62 330633 2079 79411614
Anal cancer stage II 67.34 10.22 15 330680 0 79413693
Laryngeal cancer stage IV 67.29 10.22 17 330678 12 79413681
Drug ineffective for unapproved indication 67.04 10.22 68 330627 51170 79362523
Haemorrhage 66.69 10.22 177 330518 90941 79322752
Bronchitis 66.33 10.22 297 330398 130347 79283346
Gastrointestinal disorder 66.23 10.22 271 330424 121934 79291759
Ill-defined disorder 65.93 10.22 107 330588 65768 79347925
Intentional self-injury 65.74 10.22 26 330669 32393 79381300
Poisoning deliberate 65.31 10.22 3 330692 18825 79394868
Nasopharyngeal cancer 65.30 10.22 26 330669 167 79413526
Erythema 65.22 10.22 1294 329401 221996 79191697
Suicidal ideation 64.88 10.22 137 330558 76203 79337490
Sopor 64.47 10.22 28 330667 32982 79380711
Inflammation 64.25 10.22 188 330507 93565 79320128
Oesophageal cancer metastatic 64.03 10.22 29 330666 266 79413427
Haemoglobin urine present 63.51 10.22 43 330652 912 79412781
Injection site erythema 63.43 10.22 144 330551 78053 79335640
Serotonin syndrome 63.31 10.22 56 330639 44971 79368722
Head and neck cancer stage IV 62.85 10.22 14 330681 0 79413693
Bile duct cancer stage IV 62.85 10.22 14 330681 0 79413693
Cholestasis 62.82 10.22 74 330621 52035 79361658
Cerebral infarction 62.80 10.22 58 330637 45618 79368075
Alanine aminotransferase increased 62.38 10.22 406 330289 162164 79251529
Cytokine release syndrome 60.69 10.22 37 330658 35961 79377732
Disease recurrence 60.66 10.22 56 330639 44053 79369640
Hepatic failure 58.88 10.22 102 330593 61110 79352583
Agitation 58.61 10.22 214 330481 99501 79314192
Acute myocardial infarction 58.41 10.22 147 330548 76889 79336804
Blood creatine phosphokinase increased 58.37 10.22 116 330579 65974 79347719
Bone erosion 58.35 10.22 4 330691 17843 79395850
Adverse drug reaction 58.24 10.22 117 330578 66275 79347418
Cytomegalovirus infection 57.63 10.22 55 330640 42589 79371104
Gastrointestinal stromal tumour 57.33 10.22 52 330643 1711 79411982
Device expulsion 57.13 10.22 18 330677 25843 79387850
Poisoning 56.89 10.22 17 330678 25255 79388438
Bacterial test positive 56.83 10.22 107 330588 7342 79406351
Full blood count abnormal 56.11 10.22 51 330644 40423 79373270
Abortion spontaneous 56.11 10.22 26 330669 29481 79384212
Seizure 55.79 10.22 507 330188 188327 79225366
Spinal cord neoplasm 55.77 10.22 29 330666 369 79413324
Delirium 55.62 10.22 173 330522 84454 79329239
Diabetes mellitus 55.32 10.22 155 330540 78235 79335458
Respiratory arrest 55.26 10.22 96 330599 57454 79356239
Coronary artery disease 55.22 10.22 118 330577 65356 79348337
Tenosynovitis stenosans 55.21 10.22 66 330629 3012 79410681
Ascites 54.38 10.22 148 330547 75414 79338279
Bladder cancer stage I, without cancer in situ 53.88 10.22 12 330683 0 79413693
Small intestine carcinoma stage 0 53.88 10.22 12 330683 0 79413693
Hepatocellular injury 53.80 10.22 71 330624 47522 79366171
Abdominal pain 53.74 10.22 1218 329477 388351 79025342
Blood urine present 53.46 10.22 202 330493 21095 79392598
Pericardial effusion 53.27 10.22 68 330627 46169 79367524
Hypokalaemia 53.12 10.22 364 330331 143676 79270017
Orthostatic hypotension 52.74 10.22 95 330600 56069 79357624
Computerised tomogram thorax 52.43 10.22 29 330666 421 79413272
Shock 52.33 10.22 62 330633 43486 79370207
Incorrect route of product administration 52.12 10.22 41 330654 34888 79378805
Acute myeloid leukaemia 51.71 10.22 32 330663 30853 79382840
Osteonecrosis of jaw 51.45 10.22 62 330633 43164 79370529
Arrhythmia 51.20 10.22 111 330584 61161 79352532
Hypertension 51.15 10.22 1016 329679 329976 79083717
Cerebral haemorrhage 51.13 10.22 101 330594 57572 79356121
Gamma-glutamyltransferase decreased 51.02 10.22 27 330668 357 79413336
Hepatitis 50.79 10.22 96 330599 55631 79358062
Chest pain 50.37 10.22 845 329850 281459 79132234
Localised infection 50.15 10.22 49 330646 37526 79376167
Accidental overdose 50.13 10.22 54 330641 39527 79374166
Pneumocystis jirovecii pneumonia 49.98 10.22 37 330658 32471 79381222
Drug reaction with eosinophilia and systemic symptoms 49.95 10.22 121 330574 64123 79349570
Aggression 49.85 10.22 84 330611 50874 79362819
Synovial fluid analysis 49.76 10.22 55 330640 2304 79411389
Blood cholesterol increased 49.64 10.22 179 330516 83541 79330152
Pulmonary oedema 49.53 10.22 193 330502 88061 79325632
Bone marrow failure 49.30 10.22 85 330610 51022 79362671
Haematoma 49.27 10.22 88 330607 52107 79361586
Nasopharyngeal cancer stage IV 49.03 10.22 12 330683 6 79413687
Cellulitis 48.95 10.22 259 330436 108801 79304892
Exposure during pregnancy 48.91 10.22 234 330461 100898 79312795
Eosinophilia 48.89 10.22 70 330625 45275 79368418
Contusion 48.62 10.22 389 330306 148387 79265306
Musculoskeletal pain 48.24 10.22 239 330456 102115 79311578
Inappropriate schedule of product administration 48.13 10.22 340 330355 133288 79280405
Blood pressure increased 48.08 10.22 603 330092 210757 79202936
Rectal cancer stage III 48 10.22 13 330682 16 79413677
Blood pressure fluctuation 47.21 10.22 133 330562 67012 79346681
Infusion site coldness 47.19 10.22 22 330673 217 79413476
Agranulocytosis 47.10 10.22 71 330624 44959 79368734
International normalised ratio increased 47.08 10.22 186 330509 84535 79329158
Computerised tomogram thorax abnormal 46.93 10.22 54 330641 2365 79411328
Myocarditis 46.48 10.22 16 330679 21717 79391976
Platelet count decreased 46.31 10.22 550 330145 194114 79219579
Anal cancer 45.87 10.22 33 330662 774 79412919
Posterior reversible encephalopathy syndrome 45.74 10.22 26 330669 26255 79387438
Gallbladder cancer stage 0 44.90 10.22 10 330685 0 79413693
Epiglottic cancer 44.90 10.22 10 330685 0 79413693
Mastocytosis 44.87 10.22 28 330667 514 79413179
Laryngeal cancer stage III 44.87 10.22 13 330682 24 79413669
Gastrooesophageal reflux disease 44.65 10.22 643 330052 103603 79310090
Subarachnoid haemorrhage 44.33 10.22 23 330672 24442 79389251
Subdural haematoma 44.31 10.22 39 330656 31395 79382298
Muscular weakness 44.29 10.22 439 330256 160290 79253403
Liver disorder 44.16 10.22 153 330542 72264 79341429
Intraductal proliferative breast lesion 44 10.22 53 330642 2438 79411255
Nitrite urine present 43.98 10.22 38 330657 1171 79412522
Colitis 43.95 10.22 156 330539 73151 79340542
Headache 43.69 10.22 2241 328454 651531 78762162
Urine ketone body present 43.11 10.22 63 330632 3502 79410191
Aphasia 43.03 10.22 80 330615 46652 79367041
Herpes zoster 42.93 10.22 219 330476 92864 79320829
Staphylococcal infection 42.83 10.22 113 330582 58182 79355511
Hypercalcaemia 42.76 10.22 58 330637 38372 79375321
Rectal haemorrhage 42.72 10.22 167 330528 76133 79337560
Medication error 42.55 10.22 144 330551 68498 79345195
Coma 42.44 10.22 244 330451 100405 79313288
Sedation complication 42.39 10.22 7 330688 15662 79398031
Femur fracture 42.34 10.22 59 330636 38593 79375100
Rectal cancer stage II 42.28 10.22 10 330685 3 79413690
Myelodysplastic syndrome 42.22 10.22 38 330657 30263 79383430
Joint stiffness 42.11 10.22 65 330630 40765 79372928
Pathogen resistance 42.10 10.22 5 330690 14337 79399356
Malignant neoplasm of spinal cord 41.96 10.22 15 330680 68 79413625
Labelled drug-drug interaction medication error 41.83 10.22 32 330663 27618 79386075
Carcinoid tumour 41.69 10.22 27 330668 530 79413163
Diabetic ketoacidosis 41.62 10.22 48 330647 34074 79379619
Endometrial cancer stage I 41.42 10.22 19 330676 180 79413513
Unevaluable event 41.41 10.22 107 330588 55478 79358215
Prescribed underdose 41.14 10.22 37 330658 29477 79384216
Neuropathy peripheral 41.03 10.22 381 330314 140924 79272769
Device malfunction 40.62 10.22 19 330676 21429 79392264
Brain stem glioma 40.62 10.22 19 330676 189 79413504
Myalgia 40.60 10.22 534 330161 185107 79228586
Generalised tonic-clonic seizure 40.58 10.22 75 330620 43835 79369858
Muscle spasms 40.29 10.22 497 330198 174233 79239460
Type 2 diabetes mellitus 40.27 10.22 113 330582 57009 79356684
Fracture 40.24 10.22 20 330675 21781 79391912
Ischaemic stroke 39.99 10.22 47 330648 33084 79380609
Balance disorder 39.91 10.22 243 330452 98614 79315079
Vulval cancer 39.90 10.22 26 330669 516 79413177
Psychotic disorder 39.81 10.22 69 330626 41333 79372360
Panniculitis 39.79 10.22 3 330692 12368 79401325
Acute respiratory failure 39.63 10.22 121 330574 59420 79354273
Aspergillus infection 39.46 10.22 15 330680 19146 79394547
Pregnancy 39.46 10.22 32 330663 26819 79386874
Neurotoxicity 39.39 10.22 46 330649 32472 79381221
Cough 39.38 10.22 1189 329506 365600 79048093
Acute hepatic failure 39.35 10.22 40 330655 30073 79383620
Loss of employment 39.24 10.22 51 330644 2536 79411157
Victim of child abuse 38.88 10.22 32 330663 921 79412772
Haemophagocytic lymphohistiocytosis 38.87 10.22 21 330674 21816 79391877
Cataract 38.73 10.22 130 330565 61990 79351703
Abnormal behaviour 38.51 10.22 57 330638 36364 79377329
Congenital hydrocephalus 38.39 10.22 14 330681 68 79413625
Cardiac disorder 38.06 10.22 142 330553 65615 79348078
Disseminated intravascular coagulation 37.98 10.22 56 330639 35786 79377907
Dysarthria 37.87 10.22 148 330547 67474 79346219
Injection site haemorrhage 37.59 10.22 36 330659 27834 79385859
Creatinine renal clearance decreased 37.30 10.22 16 330679 18986 79394707
Sarcoma 37.29 10.22 31 330664 905 79412788
Drug level increased 37.29 10.22 67 330628 39584 79374109
Tremor 37.28 10.22 489 330206 169594 79244099
Ureteric cancer 36.98 10.22 20 330675 277 79413416
Respiratory tract infection 36.83 10.22 93 330602 48596 79365097
Nasal sinus cancer 36.82 10.22 14 330681 78 79413615
Enthesopathy 36.81 10.22 3 330692 11605 79402088
Transaminases increased 36.74 10.22 102 330593 51641 79362052
Status epilepticus 36.60 10.22 30 330665 25011 79388682
Device issue 36.58 10.22 35 330660 27073 79386620
Loss of consciousness 36.39 10.22 484 330211 167459 79246234
Insomnia 35.93 10.22 759 329936 244411 79169282
Laryngeal cancer stage II 35.92 10.22 8 330687 0 79413693
Tongue cancer metastatic 35.92 10.22 8 330687 0 79413693
Malignant splenic neoplasm 35.92 10.22 8 330687 0 79413693
Specific gravity urine increased 35.90 10.22 23 330672 443 79413250
Illness 35.84 10.22 88 330607 46423 79367270
Device dislocation 35.67 10.22 33 330662 25937 79387756
Sense of oppression 35.63 10.22 38 330657 1528 79412165
Hyperglycaemia 35.63 10.22 160 330535 70175 79343518
Pulmonary hypertension 35.48 10.22 93 330602 47987 79365706
Pulmonary fibrosis 35.15 10.22 82 330613 44030 79369663
Cognitive disorder 34.86 10.22 160 330535 69766 79343927
No adverse event 34.84 10.22 63 330632 37129 79376564
Adrenal insufficiency 34.83 10.22 40 330655 28447 79385246
Specific gravity urine decreased 34.82 10.22 29 330666 849 79412844
Dystonia 34.69 10.22 23 330672 21376 79392317
Hepatotoxicity 34.44 10.22 104 330591 51248 79362445
Acute respiratory distress syndrome 34.25 10.22 83 330612 43984 79369709
Productive cough 34.17 10.22 220 330475 88111 79325582
Sciatica 34.15 10.22 53 330642 33169 79380524
Hospitalisation 33.82 10.22 240 330455 93996 79319697
Scleritis 33.77 10.22 63 330632 4293 79409400
Immune reconstitution inflammatory syndrome 33.64 10.22 8 330687 13833 79399860
Lip dry 33.58 10.22 11 330684 15407 79398286
Haemodynamic instability 33.54 10.22 15 330680 17367 79396326
Second primary malignancy 33.51 10.22 9 330686 14341 79399352
Product administration error 33.51 10.22 50 330645 31796 79381897
Dyskinesia 33.50 10.22 86 330609 44687 79369006
Blood calcium decreased 33.44 10.22 50 330645 31769 79381924
Brain neoplasm 33.43 10.22 73 330622 5573 79408120
Rectal cancer stage IV 33.38 10.22 8 330687 3 79413690
Cardiogenic shock 33.33 10.22 78 330617 41836 79371857
Visual acuity reduced 33.27 10.22 44 330651 29425 79384268
Psoriasis 33.21 10.22 226 330469 89361 79324332
Miosis 33.12 10.22 12 330683 15777 79397916
Dyspnoea exertional 33.11 10.22 218 330477 86855 79326838
Bile duct cancer 32.90 10.22 30 330665 994 79412699
Head injury 32.64 10.22 66 330629 37303 79376390
Unresponsive to stimuli 32.60 10.22 120 330575 55668 79358025
Drug tolerance decreased 32.54 10.22 7 330688 12971 79400722
Cardiomyopathy 32.45 10.22 43 330652 28731 79384962
Mental status changes 32.33 10.22 155 330540 66804 79346889
Therapy partial responder 32.05 10.22 16 330679 17381 79396312
Lung disorder 32.00 10.22 199 330496 80358 79333335
Cytomegalovirus viraemia 31.98 10.22 7 330688 12814 79400879
Mitral valve incompetence 31.89 10.22 43 330652 28522 79385171
Melaena 31.76 10.22 137 330558 60753 79352940
Lymphadenopathy 31.46 10.22 114 330581 53133 79360560
Follicular lymphoma stage III 31.43 10.22 7 330688 0 79413693
Sleep disorder due to a general medical condition 31.43 10.22 10 330685 14267 79399426
Blood creatinine increased 31.39 10.22 453 330242 154604 79259089
Skin necrosis 31.32 10.22 18 330677 18069 79395624
Lower limb fracture 31.30 10.22 30 330665 23185 79390508
Influenza 31.27 10.22 365 330330 129241 79284452
Transient ischaemic attack 31.02 10.22 113 330582 52582 79361111
Deformity 30.97 10.22 99 330596 9506 79404187
Vasculitis 30.96 10.22 35 330660 25067 79388626
Breast cancer in situ 30.95 10.22 28 330667 918 79412775
Parkinsonism 30.94 10.22 15 330680 16569 79397124
Procedural pain 30.93 10.22 30 330665 23054 79390639
Perfume sensitivity 30.71 10.22 27 330668 852 79412841
Respiratory disorder 30.69 10.22 90 330605 44766 79368927
Colitis ulcerative 30.66 10.22 61 330634 34681 79379012
Pneumonitis 30.49 10.22 139 330556 60721 79352972
Night sweats 30.47 10.22 112 330583 51983 79361710
Angina pectoris 30.41 10.22 111 330584 51621 79362072
Head and neck cancer 30.37 10.22 18 330677 300 79413393
Injection site pruritus 30.28 10.22 83 330612 42200 79371493
Peripheral venous disease 30.28 10.22 14 330681 15895 79397798
Nephrolithiasis 30.24 10.22 116 330579 53175 79360518
Band neutrophil percentage increased 30.17 10.22 20 330675 409 79413284
Device difficult to use 30.14 10.22 9 330686 13376 79400317
Allergy to chemicals 30.05 10.22 45 330650 2557 79411136
Thyroxine free increased 30.00 10.22 31 330664 1201 79412492
Palpitations 29.99 10.22 358 330337 126252 79287441
Bronchopulmonary aspergillosis 29.84 10.22 29 330666 22265 79391428
Blood alkaline phosphatase increased 29.80 10.22 149 330546 63515 79350178
Bursitis 29.69 10.22 252 330443 35592 79378101
Bladder cancer stage 0, with cancer in situ 29.58 10.22 11 330684 57 79413636
Pulmonary arterial hypertension 29.40 10.22 45 330650 28321 79385372
Disorientation 29.34 10.22 147 330548 62629 79351064
Memory impairment 29.20 10.22 309 330386 111425 79302268
Haematotoxicity 29.01 10.22 14 330681 15505 79398188
Liver function test abnormal 28.99 10.22 153 330542 64322 79349371
Chronic lymphocytic leukaemia stage 1 28.94 10.22 7 330688 3 79413690
Tongue neoplasm 28.91 10.22 12 330683 87 79413606
Tinnitus 28.86 10.22 91 330604 44242 79369451
Muscle rigidity 28.84 10.22 24 330671 19858 79393835
Haemoglobin decreased 28.76 10.22 701 329994 221418 79192275
Product quality issue 28.76 10.22 61 330634 33879 79379814
Mean cell haemoglobin decreased 28.71 10.22 73 330622 6151 79407542
Hepatic cirrhosis 28.53 10.22 64 330631 34842 79378851
Bilirubin urine present 28.45 10.22 18 330677 339 79413354
Bundle branch block right 28.35 10.22 6 330689 11245 79402448
Gastric cancer recurrent 28.25 10.22 8 330687 13 79413680
Fibromyalgia 28.20 10.22 154 330541 64186 79349507
Sudden death 28.18 10.22 31 330664 22480 79391213
Drug withdrawal syndrome 28.10 10.22 64 330631 34654 79379039
Hip fracture 28.02 10.22 53 330642 30708 79382985
Cardiotoxicity 27.98 10.22 8 330687 12231 79401462
Splenic neoplasm malignancy unspecified 27.86 10.22 10 330685 46 79413647
Ankylosing spondylitis 27.86 10.22 8 330687 12197 79401496
Polyarthritis 27.85 10.22 8 330687 12194 79401499
Haemolytic anaemia 27.76 10.22 20 330675 17800 79395893
Endometrial cancer stage II 27.68 10.22 7 330688 5 79413688
Joint injury 27.67 10.22 55 330640 31280 79382413
Cells in urine 27.66 10.22 15 330680 209 79413484
Toothache 27.54 10.22 159 330536 19811 79393882
Infective pulmonary exacerbation of cystic fibrosis 27.52 10.22 116 330579 12735 79400958
Graft versus host disease 27.41 10.22 14 330681 15012 79398681
Progressive multifocal leukoencephalopathy 27.33 10.22 27 330668 20573 79393120
Malignant peritoneal neoplasm 27.11 10.22 23 330672 691 79413002
Cardiac neoplasm malignant 26.94 10.22 6 330689 0 79413693
Anal cancer stage I 26.94 10.22 6 330689 0 79413693
Bile duct cancer stage III 26.94 10.22 6 330689 0 79413693
Endometrial cancer stage III 26.94 10.22 6 330689 0 79413693
Haematuria 26.85 10.22 171 330524 68665 79345028
Bacterial infection 26.69 10.22 56 330639 31224 79382469
Colon cancer stage 0 26.60 10.22 7 330688 7 79413686
Clostridium difficile colitis 26.54 10.22 59 330636 32224 79381469
Venoocclusive liver disease 26.35 10.22 8 330687 11763 79401930
Musculoskeletal disorder 26.35 10.22 30 330665 21418 79392275
Blepharospasm 26.34 10.22 68 330627 5783 79407910
Osteonecrosis 26.25 10.22 56 330639 31039 79382654
Clear cell renal cell carcinoma 26.19 10.22 42 330653 2534 79411159
Hypervolaemia 26.16 10.22 90 330605 42600 79371093
Thrombotic microangiopathy 26.12 10.22 27 330668 20142 79393551
Blood bilirubin increased 26.11 10.22 164 330531 66068 79347625
Uveitis 26.08 10.22 19 330676 16811 79396882
Pneumonia bacterial 26.04 10.22 25 330670 19306 79394387
Multiple-drug resistance 26.03 10.22 3 330692 8805 79404888
Treatment noncompliance 25.82 10.22 120 330575 52148 79361545
Movement disorder 25.69 10.22 46 330649 27213 79386480
Cytomegalovirus infection reactivation 25.68 10.22 3 330692 8713 79404980
Urinary retention 25.67 10.22 134 330561 56496 79357197
Stress 25.61 10.22 209 330486 79403 79334290
Coagulopathy 25.54 10.22 71 330624 35935 79377758
Splenomegaly 25.52 10.22 29 330666 20725 79392968
Clostridium difficile infection 25.48 10.22 91 330604 42594 79371099
Toxic skin eruption 25.46 10.22 33 330662 22260 79391433
Drug use disorder 25.43 10.22 3 330692 8648 79405045
Blood thyroid stimulating hormone decreased 25.29 10.22 66 330629 5650 79408043
Tri-iodothyronine free increased 25.25 10.22 15 330680 251 79413442
Precancerous condition 25.21 10.22 18 330677 417 79413276
Joint dislocation 25.12 10.22 20 330675 16919 79396774
Tuberculosis 25.09 10.22 16 330679 15182 79398511
Anuria 25.02 10.22 30 330665 20933 79392760
Rash erythematous 25.00 10.22 357 330338 57412 79356281
Urinary casts 24.99 10.22 28 330667 1191 79412502
Epidural lipomatosis 24.82 10.22 28 330667 1200 79412493
Oropharyngeal oedema 24.81 10.22 18 330677 428 79413265
Adjustment disorder with depressed mood 24.71 10.22 4 330691 9082 79404611
Macular degeneration 24.71 10.22 8 330687 11288 79402405
Cestode infection 24.64 10.22 15 330680 263 79413430
Skin exfoliation 24.63 10.22 131 330564 54969 79358724
Right ventricular failure 24.62 10.22 37 330658 23460 79390233
Injection site swelling 24.61 10.22 106 330589 47026 79366667
Premature delivery 24.54 10.22 37 330658 23430 79390263
Hyperreflexia 24.42 10.22 3 330692 8382 79405311
Electrocardiogram QT prolonged 24.42 10.22 248 330447 90138 79323555
Sleep apnoea syndrome 24.37 10.22 74 330621 36404 79377289
Product storage error 24.27 10.22 19 330676 16207 79397486
Neoplasm progression 24.16 10.22 121 330574 51561 79362132
Oesophageal polyp 24.15 10.22 10 330685 72 79413621
Malignant melanoma 24.14 10.22 123 330572 14618 79399075
Epistaxis 23.92 10.22 322 330373 111193 79302500
Metastases to liver 23.89 10.22 51 330644 28263 79385430
Blood cholesterol 23.85 10.22 21 330674 664 79413029
Therapy cessation 23.83 10.22 78 330617 37484 79376209
Anosmia 23.81 10.22 4 330691 8840 79404853
Abdominal pain lower 23.81 10.22 61 330634 31721 79381972
Band neutrophil count increased 23.72 10.22 21 330674 669 79413024
Glycosylated haemoglobin increased 23.59 10.22 27 330668 19233 79394460
Dry skin 23.51 10.22 175 330520 67820 79345873
Salivary hypersecretion 23.45 10.22 15 330680 14209 79399484
Eye disorder 23.45 10.22 38 330657 23374 79390319
Restlessness 23.40 10.22 106 330589 46386 79367307
Akathisia 23.24 10.22 13 330682 13246 79400447
Dry mouth 23.17 10.22 243 330452 87776 79325917
Hemiplegia 22.97 10.22 17 330678 14922 79398771
Exposure to toxic agent 22.84 10.22 5 330690 9153 79404540
Red cell distribution width increased 22.77 10.22 124 330571 15118 79398575
Pulmonary thrombosis 22.72 10.22 11 330684 12160 79401533
Feeling hot 22.69 10.22 361 330334 59373 79354320
Respiratory acidosis 22.68 10.22 9 330686 11191 79402502
Cystitis 22.68 10.22 127 330568 52605 79361088
Breast disorder 22.64 10.22 35 330660 2046 79411647
Rectal cancer 22.62 10.22 47 330648 3466 79410227
Thrombosis 22.62 10.22 231 330464 83869 79329824
Acute graft versus host disease 22.60 10.22 7 330688 10160 79403533
Delusion 22.54 10.22 31 330664 20392 79393301
Prostate cancer recurrent 22.52 10.22 22 330673 796 79412897
Mean cell haemoglobin concentration increased 22.49 10.22 23 330672 880 79412813
Endocrine neoplasm malignant 22.45 10.22 5 330690 0 79413693
Head and neck cancer stage I 22.45 10.22 5 330690 0 79413693
Bile duct cancer stage II 22.45 10.22 5 330690 0 79413693
Salivary gland cancer stage I 22.45 10.22 5 330690 0 79413693
Cytopenia 22.44 10.22 31 330664 20352 79393341
Pallor 22.39 10.22 119 330576 49943 79363750
Lip pruritus 22.30 10.22 23 330672 889 79412804
Surgery 22.23 10.22 66 330629 32700 79380993
Wound infection 22.15 10.22 41 330654 23950 79389743
Blood parathyroid hormone decreased 22.11 10.22 8 330687 10528 79403165
Renal tubular necrosis 22.06 10.22 44 330651 24995 79388698
Unintentional medical device removal 21.88 10.22 3 330692 7709 79405984
Cushingoid 21.86 10.22 88 330607 9464 79404229
Bradycardia 21.85 10.22 413 330282 135144 79278549
Arteriosclerosis 21.84 10.22 26 330669 18201 79395492
Blood pressure decreased 21.77 10.22 286 330409 99180 79314513
Leukopenia 21.66 10.22 346 330349 116167 79297526
Shock haemorrhagic 21.59 10.22 31 330664 20029 79393664
Facet joint syndrome 21.42 10.22 10 330685 11292 79402401
Injection site induration 21.40 10.22 7 330688 9812 79403881
Muscle spasticity 21.37 10.22 35 330660 21440 79392253
Leiomyosarcoma 21.25 10.22 15 330680 341 79413352
Vision blurred 21.21 10.22 310 330385 105588 79308105
Blood pressure systolic increased 21.03 10.22 177 330518 66809 79346884
Mast cell activation syndrome 21.02 10.22 20 330675 700 79412993
Urine oxalate increased 20.96 10.22 13 330682 236 79413457
Transplant rejection 20.96 10.22 30 330665 19407 79394286
Ventricular tachycardia 20.87 10.22 96 330599 41839 79371854
Hallucination 20.86 10.22 241 330454 85504 79328189
Urine leukocyte esterase 20.84 10.22 12 330683 189 79413504
Endocrine ophthalmopathy 20.84 10.22 20 330675 708 79412985
Abdominal distension 20.71 10.22 360 330335 119290 79294403
Tricuspid valve incompetence 20.69 10.22 31 330664 19681 79394012
Vertigo 20.59 10.22 185 330510 68897 79344796
Muscle twitching 20.57 10.22 45 330650 24719 79388974
Injection site urticaria 20.50 10.22 14 330681 12812 79400881
Full blood count decreased 20.46 10.22 51 330644 26768 79386925
Sickle cell anaemia with crisis 20.43 10.22 4 330691 7918 79405775
Vaginal haemorrhage 20.40 10.22 37 330658 21780 79391913
Hyperlipidaemia 20.39 10.22 49 330646 26044 79387649
Spinal fracture 20.34 10.22 27 330668 18027 79395666
Osteomyelitis 20.33 10.22 69 330626 32796 79380897
Urticaria 20.30 10.22 951 329744 184250 79229443
Lip neoplasm malignant stage unspecified 20.28 10.22 7 330688 28 79413665
Exostosis 20.25 10.22 24 330671 16834 79396859
Synovial cyst 20.13 10.22 89 330606 9976 79403717
Diverticulitis 20.10 10.22 110 330585 45826 79367867
Eosinophil percentage increased 20.08 10.22 28 330667 1490 79412203
Breath sounds abnormal 20.02 10.22 22 330673 15962 79397731
Aplastic anaemia 19.96 10.22 135 330560 17770 79395923
Product dose omission in error 19.94 10.22 4 330691 7784 79405909
Lung cancer metastatic 19.86 10.22 46 330649 3653 79410040
Oliguria 19.83 10.22 23 330672 16286 79397407
Infusion site induration 19.81 10.22 24 330671 1111 79412582
Diffuse large B-cell lymphoma 19.77 10.22 13 330682 12136 79401557
Endometrial cancer 19.74 10.22 33 330662 2061 79411632
Antinuclear antibody 19.72 10.22 16 330679 451 79413242
Malignant neoplasm of ampulla of Vater 19.71 10.22 7 330688 31 79413662
Tendon rupture 19.70 10.22 13 330682 12113 79401580
Abortion induced 19.63 10.22 3 330692 7106 79406587
Reflux gastritis 19.53 10.22 25 330670 1224 79412469
Systemic infection 19.48 10.22 8 330687 9744 79403949
Malnutrition 19.44 10.22 40 330655 22462 79391231
Irritability 19.42 10.22 96 330599 41048 79372645
Blindness 19.38 10.22 57 330638 28326 79385367
Cervix disorder 19.31 10.22 13 330682 273 79413420
Red blood cells urine 19.30 10.22 19 330676 694 79412999
Klebsiella infection 19.30 10.22 22 330673 15698 79397995
White blood cell count increased 19.25 10.22 207 330488 74426 79339267
Lethargy 19.19 10.22 230 330465 81062 79332631
Cystitis haemorrhagic 19.19 10.22 7 330688 9165 79404528
Rib fracture 19.17 10.22 56 330639 27891 79385802
Injection site bruising 19.16 10.22 96 330599 40906 79372787
Fear 19.06 10.22 39 330656 21947 79391746
Metastatic lymphoma 19.04 10.22 14 330681 340 79413353
Pulmonary alveolar haemorrhage 19.00 10.22 12 330683 11445 79402248
Lipaemic index score 18.91 10.22 10 330685 132 79413561
Polymenorrhoea 18.82 10.22 22 330673 980 79412713
Renal cancer recurrent 18.61 10.22 9 330686 97 79413596
Brain oedema 18.53 10.22 49 330646 25214 79388479
Metastatic carcinoma of the bladder 18.51 10.22 12 330683 236 79413457
Leukocytosis 18.50 10.22 105 330590 43350 79370343
Spinal compression fracture 18.46 10.22 26 330669 16932 79396761
Apathy 18.41 10.22 16 330679 12961 79400732
Purpura 18.36 10.22 33 330662 19494 79394199
Prostatomegaly 18.36 10.22 43 330652 3440 79410253
Hypogammaglobulinaemia 18.33 10.22 16 330679 12935 79400758
Road traffic accident 18.32 10.22 106 330589 43558 79370135
Colitis ischaemic 18.31 10.22 22 330673 15337 79398356
Gamma-glutamyltransferase increased 18.30 10.22 142 330553 54538 79359155
Nasal polyps 18.28 10.22 4 330691 7323 79406370
Escherichia infection 18.27 10.22 29 330666 17988 79395705
Left ventricular hypertrophy 18.18 10.22 12 330683 11179 79402514
Depressed mood 18.11 10.22 122 330573 48358 79365335
Cardiac failure chronic 18.01 10.22 12 330683 11123 79402570
Drug level below therapeutic 17.98 10.22 9 330686 9761 79403932
Head and neck cancer stage III 17.96 10.22 4 330691 0 79413693
Endometrial cancer stage IV 17.96 10.22 4 330691 0 79413693
Malignant palate neoplasm 17.96 10.22 4 330691 0 79413693
Nasopharyngeal cancer stage III 17.96 10.22 4 330691 0 79413693
Urine bilirubin decreased 17.91 10.22 10 330685 148 79413545
Hyperammonaemia 17.88 10.22 12 330683 11081 79402612
Myoclonus 17.85 10.22 57 330638 27603 79386090
Catatonia 17.79 10.22 7 330688 8749 79404944
Encephalitis 17.75 10.22 21 330674 14739 79398954
Obesity 17.73 10.22 80 330615 35045 79378648
Hypertriglyceridaemia 17.72 10.22 16 330679 12724 79400969
Thyroxine free decreased 17.71 10.22 22 330673 1045 79412648
Blood loss anaemia 17.64 10.22 23 330672 15475 79398218
Magnesium deficiency 17.59 10.22 17 330678 607 79413086
Drug tolerance 17.52 10.22 7 330688 8668 79405025
Oroantral fistula 17.49 10.22 14 330681 387 79413306
Hypovolaemia 17.45 10.22 29 330666 17662 79396031
Disturbance in attention 17.44 10.22 131 330564 50670 79363023
Triple negative breast cancer 17.41 10.22 9 330686 113 79413580
Hyperthermia 17.39 10.22 30 330665 18007 79395686
Generalised oedema 17.38 10.22 46 330649 23663 79390030
Angina unstable 17.34 10.22 26 330669 16501 79397192
Tooth erosion 17.28 10.22 14 330681 394 79413299
Upper limb fracture 17.22 10.22 30 330665 17937 79395756
Tumour lysis syndrome 17.13 10.22 47 330648 23892 79389801
Endophthalmitis 17.10 10.22 3 330692 6425 79407268
Myasthenia gravis 17.10 10.22 11 330684 10388 79403305
Enterocolitis 17.07 10.22 21 330674 14491 79399202
Affect lability 17.07 10.22 13 330682 11246 79402447
Breast cancer recurrent 17.07 10.22 38 330657 2939 79410754
Premenstrual syndrome 17.06 10.22 16 330679 550 79413143
Pulpitis dental 17.05 10.22 24 330671 1289 79412404
Ear infection 17.03 10.22 79 330616 34353 79379340
Multiple fractures 17.01 10.22 6 330689 8020 79405673
Malignant neoplasm of thorax 17.00 10.22 5 330690 10 79413683
Gastroenteritis 16.98 10.22 78 330617 34004 79379689
Hyperbilirubinaemia 16.91 10.22 49 330646 24469 79389224
Tendonitis 16.90 10.22 47 330648 23783 79389910
Atrioventricular block 16.86 10.22 20 330675 14021 79399672
Mucormycosis 16.83 10.22 7 330688 8462 79405231
Pleuritic pain 16.82 10.22 85 330610 10067 79403626
Hypothermia 16.78 10.22 44 330651 22702 79390991
Emphysema 16.76 10.22 26 330669 16274 79397419
Lymphocytic infiltration 16.73 10.22 26 330669 1527 79412166
Foot deformity 16.69 10.22 48 330647 24026 79389667
Child abuse 16.66 10.22 14 330681 415 79413278
Malignant neoplasm of eye 16.64 10.22 8 330687 85 79413608
Extrapyramidal disorder 16.63 10.22 44 330651 22635 79391058
Gestational diabetes 16.61 10.22 3 330692 6290 79407403
Autoimmune disorder 16.60 10.22 27 330668 16585 79397108
Heart rate decreased 16.58 10.22 199 330496 70117 79343576
Cachexia 16.55 10.22 13 330682 11070 79402623
Injury 16.53 10.22 224 330471 77272 79336421
Coordination abnormal 16.51 10.22 29 330666 17283 79396410
Culture urine positive 16.44 10.22 48 330647 4387 79409306
Cardiac tamponade 16.40 10.22 9 330686 9267 79404426
Walking aid user 16.33 10.22 11 330684 10137 79403556
Hereditary angioedema 16.31 10.22 54 330641 5281 79408412
Injection site rash 16.30 10.22 31 330664 17923 79395770
Jaundice 16.28 10.22 142 330553 53207 79360486
Chronic kidney disease 16.25 10.22 374 330321 65780 79347913
Dysphagia 16.20 10.22 384 330311 121752 79291941
Device related infection 16.20 10.22 80 330615 34214 79379479
Hypothyroidism 16.19 10.22 139 330556 52253 79361440
Pyelonephritis 16.16 10.22 38 330657 20350 79393343
Substance abuse 16.16 10.22 12 330683 10514 79403179
Skin ulcer 16.14 10.22 145 330550 54005 79359688
Throat tightness 16.14 10.22 182 330513 27725 79385968
Asphyxia 15.97 10.22 15 330680 11705 79401988
Arteriosclerosis coronary artery 15.96 10.22 31 330664 17785 79395908
Peritonitis bacterial 15.89 10.22 10 330685 9557 79404136
Breast disorder female 15.87 10.22 8 330687 95 79413598
Myelocyte percentage increased 15.86 10.22 11 330684 243 79413450
Foot fracture 15.85 10.22 43 330652 21938 79391755
Acute graft versus host disease in skin 15.76 10.22 6 330689 7652 79406041
Blood pressure diastolic decreased 15.75 10.22 68 330627 30148 79383545
B-cell lymphoma stage II 15.73 10.22 4 330691 3 79413690
Neck pain 15.73 10.22 219 330476 75198 79338495
Bradypnoea 15.73 10.22 3 330692 6049 79407644
Pneumopericardium 15.73 10.22 10 330685 190 79413503
Barotrauma 15.73 10.22 10 330685 190 79413503
Nasal congestion 15.71 10.22 223 330472 76329 79337364
Respiratory depth decreased 15.70 10.22 6 330689 34 79413659
Atrial tachycardia 15.69 10.22 5 330690 7128 79406565
Lung infiltration 15.65 10.22 46 330649 22866 79390827
Venous thrombosis 15.63 10.22 5 330690 7111 79406582
Motor dysfunction 15.63 10.22 23 330672 14710 79398983
Immunosuppressant drug level increased 15.61 10.22 9 330686 9018 79404675
Grip strength decreased 15.60 10.22 43 330652 21826 79391867
Nephrotic syndrome 15.58 10.22 14 330681 11160 79402533
Paranoia 15.58 10.22 36 330659 19396 79394297
Delusion of grandeur 15.46 10.22 24 330671 1408 79412285
Hepatic encephalopathy 15.45 10.22 50 330645 24116 79389577
Atelectasis 15.45 10.22 203 330492 32054 79381639
Pancreatitis 15.44 10.22 196 330499 68379 79345314
Candida infection 15.38 10.22 94 330601 38120 79375573
Demyelination 15.36 10.22 7 330688 8016 79405677
Prescribed overdose 15.35 10.22 93 330602 37790 79375903
Lupus-like syndrome 15.33 10.22 21 330674 13836 79399857
Hypercholesterolaemia 15.32 10.22 47 330648 23048 79390645
Pain of skin 15.32 10.22 23 330672 14590 79399103
Carcinoid syndrome 15.28 10.22 10 330685 200 79413493
Anal abscess 15.24 10.22 10 330685 9345 79404348
Bronchospasm 15.24 10.22 164 330531 24695 79388998
Alanine aminotransferase abnormal 15.11 10.22 9 330686 8858 79404835
Product substitution issue 15.08 10.22 39 330656 20217 79393476
Pelvic fracture 15.07 10.22 17 330678 12187 79401506
Dialysis 14.97 10.22 34 330661 18428 79395265
BK virus infection 14.91 10.22 9 330686 8795 79404898
Hyperphosphataemia 14.89 10.22 4 330691 6372 79407321
Skin lesion 14.80 10.22 107 330588 41737 79371956
Appendicitis 14.75 10.22 41 330654 20753 79392940
Therapeutic response shortened 14.74 10.22 27 330668 15836 79397857
Jaundice cholestatic 14.73 10.22 15 330680 11269 79402424
Emotional distress 14.73 10.22 101 330594 39868 79373825
Embolic stroke 14.72 10.22 7 330688 7819 79405874
Underdose 14.72 10.22 79 330616 33072 79380621
Hypoxia 14.71 10.22 321 330374 102922 79310771
Exposure via body fluid 14.68 10.22 12 330683 342 79413351
Proteinuria 14.68 10.22 77 330618 32425 79381268
Amnesia 14.66 10.22 179 330516 62878 79350815
Drug level above therapeutic 14.66 10.22 9 330686 8714 79404979
Peripheral arterial occlusive disease 14.61 10.22 8 330687 8250 79405443
Lymphocyte count abnormal 14.59 10.22 24 330671 1479 79412214
Foot operation 14.57 10.22 3 330692 5730 79407963
Lower respiratory tract infection 14.56 10.22 416 330279 128804 79284889
Cholangitis 14.50 10.22 19 330676 12757 79400936
Adenoid cystic carcinoma 14.48 10.22 5 330690 20 79413673
Muscle tension dysphonia 14.43 10.22 9 330686 165 79413528
Gingival atrophy 14.35 10.22 7 330688 77 79413616
Laryngitis 14.29 10.22 28 330667 16011 79397682
Needle issue 14.26 10.22 20 330675 13048 79400645
Peripheral ischaemia 14.24 10.22 11 330684 9446 79404247
Haemorrhage intracranial 14.23 10.22 58 330637 26135 79387558
Psychomotor retardation 14.21 10.22 4 330691 6180 79407513
Open angle glaucoma 14.18 10.22 13 330682 434 79413259
Infusion site streaking 14.17 10.22 14 330681 514 79413179
Eyelid ptosis 14.06 10.22 15 330680 11029 79402664
Bradyphrenia 14.05 10.22 14 330681 10626 79403067
Toxic encephalopathy 14.05 10.22 16 330679 11424 79402269
Hyperaesthesia 14.05 10.22 18 330677 12204 79401489
Blood uric acid increased 14.03 10.22 21 330674 13339 79400354
Wheelchair user 14.03 10.22 4 330691 6128 79407565
Ageusia 14.00 10.22 30 330665 16602 79397091
Influenza like illness 13.98 10.22 211 330484 71496 79342197
Snoring 13.96 10.22 3 330692 5563 79408130
Atrioventricular block complete 13.95 10.22 30 330665 16580 79397113
Injection site warmth 13.94 10.22 25 330670 14782 79398911
Drug monitoring procedure not performed 13.90 10.22 19 330676 992 79412701
Salivary gland cancer 13.86 10.22 13 330682 447 79413246
Arterial occlusive disease 13.83 10.22 9 330686 8447 79405246
Cerebral microhaemorrhage 13.77 10.22 10 330685 238 79413455
Vaginal cancer 13.75 10.22 9 330686 180 79413513
Pulmonary haemorrhage 13.72 10.22 25 330670 14692 79399001
Fungal infection 13.70 10.22 109 330586 41639 79372054
Cytomegalovirus chorioretinitis 13.69 10.22 3 330692 5487 79408206
Dysuria 13.68 10.22 140 330555 50811 79362882
Mean cell haemoglobin increased 13.67 10.22 44 330651 4241 79409452
Mouth ulceration 13.66 10.22 98 330597 38296 79375397
Therapeutic response unexpected 13.66 10.22 40 330655 19906 79393787
Dystrophic calcification 13.62 10.22 8 330687 131 79413562
Cerebral haematoma 13.62 10.22 8 330687 7934 79405759
Cholelithiasis 13.61 10.22 146 330549 52518 79361175
Paraneoplastic rash 13.61 10.22 7 330688 87 79413606
Nightmare 13.60 10.22 58 330637 25803 79387890
Immunosuppression 13.57 10.22 20 330675 12783 79400910
Thyroid stimulating immunoglobulin increased 13.54 10.22 7 330688 88 79413605
Metastases to lung 13.50 10.22 35 330660 18128 79395565
Electroencephalogram abnormal 13.49 10.22 3 330692 5431 79408262
Appendix cancer metastatic 13.47 10.22 3 330692 0 79413693
Small intestine carcinoma recurrent 13.47 10.22 3 330692 0 79413693
Metastases to prostate 13.47 10.22 3 330692 0 79413693
Oesophageal adenocarcinoma stage IV 13.47 10.22 3 330692 0 79413693
Bile duct cancer stage I 13.47 10.22 3 330692 0 79413693
Lip and/or oral cavity cancer stage II 13.47 10.22 3 330692 0 79413693
Oropharyngeal cancer stage IV 13.47 10.22 3 330692 0 79413693
Abdominal wall neoplasm malignant 13.47 10.22 3 330692 0 79413693
Head and neck cancer stage II 13.47 10.22 3 330692 0 79413693
Chronic lymphocytic leukaemia stage 3 13.47 10.22 3 330692 0 79413693
Anal cancer stage IV 13.47 10.22 3 330692 0 79413693
Renal cell carcinoma stage III 13.43 10.22 5 330690 26 79413667
Metabolic disorder 13.38 10.22 11 330684 9159 79404534
Pulmonary tuberculosis 13.37 10.22 8 330687 7857 79405836
Dermatitis acneiform 13.37 10.22 13 330682 9980 79403713
White blood cell count decreased 13.37 10.22 641 330054 187647 79226046
Oropharyngeal pain 13.36 10.22 348 330347 109005 79304688
Joint range of motion decreased 13.33 10.22 82 330613 33200 79380493
Metabolic encephalopathy 13.32 10.22 11 330684 9136 79404557
Inappropriate antidiuretic hormone secretion 13.24 10.22 60 330635 26253 79387440
Alcohol abuse 13.23 10.22 3 330692 5360 79408333
Systemic mastocytosis 13.09 10.22 11 330684 326 79413367
HER2 positive breast cancer 13.06 10.22 11 330684 327 79413366
Chronic leukaemia 12.99 10.22 4 330691 10 79413683
Hepatocellular carcinoma 12.95 10.22 11 330684 9010 79404683
Cardiac murmur 12.94 10.22 29 330666 15795 79397898
Cardiac failure acute 12.93 10.22 38 330657 18891 79394802
X-ray abnormal 12.92 10.22 4 330691 5809 79407884
Hepatitis fulminant 12.90 10.22 7 330688 7255 79406438
Congestive cardiomyopathy 12.88 10.22 18 330677 11762 79401931
Blindness unilateral 12.88 10.22 9 330686 8137 79405556
Speech disorder 12.87 10.22 154 330541 54291 79359402
Myopathy 12.84 10.22 43 330652 20520 79393173
Sinus tachycardia 12.75 10.22 95 330600 36813 79376880
Coronary artery stenosis 12.75 10.22 20 330675 12464 79401229
Genital haemorrhage 12.71 10.22 5 330690 6250 79407443
Haematopoietic stem cell mobilisation 12.66 10.22 9 330686 207 79413486
Hypoaesthesia 12.65 10.22 611 330084 178741 79234952
Blood creatinine decreased 12.61 10.22 65 330630 7760 79405933
Coronary artery occlusion 12.58 10.22 28 330667 15287 79398406
Bradykinesia 12.57 10.22 9 330686 8034 79405659
Live birth 12.54 10.22 38 330657 18706 79394987
Basal cell carcinoma 12.54 10.22 97 330598 37278 79376415
Ventricular hypokinesia 12.50 10.22 12 330683 9267 79404426
Pneumonia fungal 12.39 10.22 17 330678 11193 79402500
Colorectal cancer metastatic 12.33 10.22 20 330675 1218 79412475
Gastroenteritis viral 12.27 10.22 57 330638 24774 79388919
Tooth deposit 12.26 10.22 10 330685 284 79413409
Limb injury 12.22 10.22 72 330623 29456 79384237
Malignant melanoma stage III 12.20 10.22 5 330690 35 79413658
Bronchopulmonary aspergillosis allergic 12.19 10.22 34 330661 3027 79410666
Arthritis bacterial 12.18 10.22 12 330683 9154 79404539
Fear of injection 12.16 10.22 8 330687 7466 79406227
Hepatitis B 12.15 10.22 10 330685 8322 79405371
Pneumonia viral 12.15 10.22 12 330683 9146 79404547
Metastatic gastric cancer 12.15 10.22 11 330684 361 79413332
Colorectal cancer recurrent 12.15 10.22 6 330689 68 79413625
Optic discs blurred 12.15 10.22 6 330689 68 79413625
Cardiomegaly 12.14 10.22 62 330633 26290 79387403
Brain herniation 12.13 10.22 8 330687 7455 79406238
Kidney infection 12.12 10.22 48 330647 21803 79391890
Hospice care 12.08 10.22 15 330680 10309 79403384
Blood lactate dehydrogenase increased 12.07 10.22 104 330591 39066 79374627
Spinal stenosis 12.07 10.22 30 330665 15761 79397932
Granuloma 12.05 10.22 10 330685 8287 79405406
Methaemoglobinaemia 12.04 10.22 4 330691 5553 79408140
Hypersensitivity 12.04 10.22 930 329765 261309 79152384
Myositis 12.02 10.22 40 330655 19128 79394565
Dental caries 12.01 10.22 19 330676 11801 79401892
Herpes simplex 12 10.22 20 330675 12167 79401526
Paternal exposure timing unspecified 11.99 10.22 6 330689 70 79413623
Device breakage 11.99 10.22 16 330679 10659 79403034
Neuralgia 11.98 10.22 85 330610 33299 79380394
Gastric haemorrhage 11.97 10.22 28 330667 15022 79398671
Incorrect dose administered by device 11.90 10.22 3 330692 4986 79408707
Electrolyte imbalance 11.90 10.22 77 330618 30804 79382889
Haemoptysis 11.89 10.22 162 330533 55837 79357856
Polyuria 11.89 10.22 28 330667 14986 79398707
Diarrhoea haemorrhagic 11.88 10.22 23 330672 13211 79400482
Tachycardia 11.88 10.22 609 330086 177159 79236534
Hepatic enzyme abnormal 11.86 10.22 9 330686 7801 79405892
Pancreatitis acute 11.84 10.22 140 330555 49464 79364229
Pneumonia cytomegaloviral 11.83 10.22 3 330692 4966 79408727
Upper gastrointestinal haemorrhage 11.82 10.22 112 330583 41268 79372425
Type 1 diabetes mellitus 11.82 10.22 7 330688 6912 79406781
Hyperkeratosis 11.80 10.22 9 330686 7781 79405912
Pemphigoid 11.78 10.22 29 330666 15286 79398407
Blood sodium decreased 11.78 10.22 85 330610 33170 79380523
Enterococcal infection 11.77 10.22 30 330665 15630 79398063
Malignant melanoma stage IV 11.74 10.22 7 330688 118 79413575
Cytomegalovirus test positive 11.68 10.22 5 330690 5942 79407751
Organising pneumonia 11.68 10.22 17 330678 10922 79402771
Ankle fracture 11.64 10.22 34 330661 16935 79396758
Mydriasis 11.64 10.22 36 330659 17607 79396086
Respiratory tract congestion 11.60 10.22 43 330652 19911 79393782
Lymphocytic leukaemia 11.55 10.22 9 330686 239 79413454
Intraventricular haemorrhage 11.54 10.22 3 330692 4884 79408809
Skin haemorrhage 11.49 10.22 20 330675 11961 79401732
Hypertonia 11.42 10.22 8 330687 7224 79406469
Myelocyte count increased 11.41 10.22 15 330680 754 79412939
Orthopnoea 11.41 10.22 15 330680 10058 79403635
Oesophageal dysplasia 11.40 10.22 3 330692 3 79413690
Large cell lung cancer stage IV 11.40 10.22 3 330692 3 79413690
Rebound effect 11.40 10.22 8 330687 7218 79406475
Thyroid cancer metastatic 11.37 10.22 8 330687 181 79413512
Precancerous cells present 11.35 10.22 19 330676 1188 79412505
Behaviour disorder 11.34 10.22 6 330689 6307 79407386
Vasodilatation 11.32 10.22 34 330661 3157 79410536
Total lung capacity decreased 11.31 10.22 32 330663 2873 79410820
Tooth fracture 11.28 10.22 19 330676 11511 79402182
Peritonitis 11.27 10.22 69 330626 27967 79385726
Nocturia 11.25 10.22 25 330670 13656 79400037
Excessive eye blinking 11.24 10.22 23 330672 1678 79412015
Bundle branch block left 11.24 10.22 19 330676 11494 79402199
Staphylococcal sepsis 11.24 10.22 28 330667 14698 79398995
Blood potassium decreased 11.21 10.22 131 330564 46381 79367312
Potentiating drug interaction 11.20 10.22 12 330683 8807 79404886
Eosinophilic pneumonia 11.20 10.22 4 330691 5306 79408387
Chronic spontaneous urticaria 11.16 10.22 19 330676 1205 79412488
Anti-thyroid antibody positive 11.12 10.22 12 330683 489 79413204
Renal cell carcinoma stage I 11.12 10.22 5 330690 45 79413648
Palmar-plantar erythrodysaesthesia syndrome 11.11 10.22 86 330609 33048 79380645
Oropharyngeal cancer 11.10 10.22 7 330688 131 79413562
Testicular disorder 11.06 10.22 9 330686 255 79413438
Hypoalbuminaemia 11.05 10.22 48 330647 21249 79392444
Carotid artery stenosis 11.03 10.22 12 330683 8746 79404947
Antinuclear antibody positive 11.00 10.22 63 330632 7827 79405866
Spondylitis 10.99 10.22 3 330692 4728 79408965
Leukoencephalopathy 10.98 10.22 10 330685 7919 79405774
Diabetes insipidus 10.95 10.22 4 330691 5233 79408460
Endocrine neoplasm 10.94 10.22 3 330692 4 79413689
Extravasation blood 10.93 10.22 11 330684 413 79413280
Pseudomonal sepsis 10.90 10.22 6 330689 6168 79407525
White blood cells urine 10.89 10.22 12 330683 501 79413192
Pruritus 10.88 10.22 1452 329243 393196 79020497
Nasal ulcer 10.82 10.22 26 330669 2114 79411579
Intestinal obstruction 10.82 10.22 120 330575 42900 79370793
Dementia 10.81 10.22 59 330636 24600 79389093
Oral herpes 10.81 10.22 68 330627 27386 79386307
Visual impairment 10.78 10.22 295 330400 91836 79321857
Blood urea increased 10.78 10.22 140 330555 48650 79365043
Constipation 10.72 10.22 1019 329676 282031 79131662
Hypoacusis 10.71 10.22 77 330618 30073 79383620
Incorrect product administration duration 10.70 10.22 21 330674 12001 79401692
Psychomotor hyperactivity 10.68 10.22 35 330660 16814 79396879
Hypertensive crisis 10.67 10.22 47 330648 20723 79392970
Soft tissue sarcoma 10.65 10.22 8 330687 201 79413492
Wrong product administered 10.65 10.22 13 330682 8999 79404694
Complication associated with device 10.64 10.22 37 330658 17459 79396234
Red blood cell count increased 10.63 10.22 40 330655 4168 79409525
Rash maculo-papular 10.60 10.22 166 330529 55912 79357781
Malignant neoplasm of thymus 10.56 10.22 4 330691 22 79413671
Reversible airways obstruction 10.54 10.22 26 330669 2150 79411543
Hallucination, auditory 10.52 10.22 47 330648 20646 79393047
Eyelid skin dryness 10.51 10.22 8 330687 205 79413488
Sexual dysfunction 10.50 10.22 10 330685 7753 79405940
Nasal neoplasm 10.48 10.22 8 330687 206 79413487
Oral disorder 10.48 10.22 16 330679 10079 79403614
Renal tubular disorder 10.48 10.22 7 330688 6479 79407214
Neutrophil count decreased 10.45 10.22 303 330392 93656 79320037
Left ventricular dysfunction 10.44 10.22 43 330652 19318 79394375
Hypercapnia 10.44 10.22 13 330682 8922 79404771
Rhinitis allergic 10.44 10.22 22 330673 12247 79401446
Rash papular 10.42 10.22 51 330644 21865 79391828
Osteopenia 10.40 10.22 40 330655 18324 79395369
Dermatitis atopic 10.38 10.22 16 330679 10040 79403653
Skin hyperpigmentation 10.37 10.22 9 330686 7294 79406399
Staphylococcal bacteraemia 10.32 10.22 22 330673 12196 79401497
Eye pruritus 10.29 10.22 47 330648 20523 79393170
Crepitations 10.27 10.22 74 330621 9943 79403750
Sinus disorder 10.27 10.22 53 330642 22411 79391282

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BA02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists
FDA MoA N0000000151 Histamine H2 Receptor Antagonists
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006635 Histamine H2 Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37961 H2 receptor antagonists
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
FDA EPC N0000175784 Histamine-2 Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Heartburn indication 16331000
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
Duodenal Ulcer due to H. Pylori indication
Gastric Hypersecretory Conditions indication
Maintenance of Healing Gastric Ulcer indication
Upper gastrointestinal hemorrhage off-label use 37372002
Prevention of NSAID-Induced Gastric Ulcer off-label use
Fatty Stool as Cystic Fibrosis Intestinal Manifestation off-label use
Prevention of Stress Ulcer off-label use
NSAID-Induced Gastric Ulcer off-label use
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Malignant tumor of stomach contraindication 363349007 DOID:10534
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic
pKa2 6.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H2 receptor GPCR ANTAGONIST Kd 6.86 WOMBAT-PK CHEMBL
Acetylcholinesterase Enzyme IC50 6.19 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.08 CHEMBL
Histamine H2 receptor GPCR Kd 7.19 CHEMBL
Histamine H2 receptor GPCR ANTAGONIST Ki 6.20 IUPHAR

External reference:

IDSource
D00422 KEGG_DRUG
66357-59-3 SECONDARY_CAS_RN
4018896 VANDF
4019927 VANDF
CHEBI:8776 CHEBI
CHEMBL1790041 ChEMBL_ID
CHEMBL2110372 ChEMBL_ID
1234 IUPHAR_LIGAND_ID
DB00863 DRUGBANK_ID
152523 RXNORM
1431 MMSL
5413 MMSL
911 MMSL
d00021 MMSL
003416 NDDF
004444 NDDF
24202000 SNOMEDCT_US
372755005 SNOMEDCT_US
48174005 SNOMEDCT_US
D011899 MESH_DESCRIPTOR_UI
C0034665 UMLSCUI
4660 INN_ID
3001055 PUBCHEM_CID
884KT10YB7 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0727 SYRUP 15 mg ORAL ANDA 23 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0121-4727 SYRUP 15 mg ORAL ANDA 23 sections
Wal-Zan HUMAN OTC DRUG LABEL 1 0363-0010 TABLET, COATED 150 mg ORAL ANDA 13 sections
Wal-Zan 75 HUMAN OTC DRUG LABEL 1 0363-0131 TABLET 75 mg ORAL ANDA 14 sections
Ranitidine HUMAN OTC DRUG LABEL 1 0363-0352 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
Wal-Zan HUMAN OTC DRUG LABEL 1 0363-0362 TABLET 150 mg ORAL ANDA 14 sections
Ranitidine HUMAN OTC DRUG LABEL 1 0440-2300 TABLET, FILM COATED 150 mg ORAL ANDA 14 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0440-8300 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 0440-8305 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2855 CAPSULE 150 mg ORAL ANDA 24 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2855 CAPSULE 150 mg ORAL ANDA 24 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2865 CAPSULE 300 mg ORAL ANDA 24 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2865 CAPSULE 300 mg ORAL ANDA 24 sections
ranitidine 75 HUMAN OTC DRUG LABEL 1 0904-6715 TABLET, COATED 75 mg ORAL ANDA 15 sections
Ranitidine HUMAN OTC DRUG LABEL 1 0904-6921 TABLET 75 mg ORAL ANDA 14 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-056 TABLET 150 mg ORAL ANDA 11 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-438 TABLET, FILM COATED 150 mg ORAL ANDA 24 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 10544-516 TABLET 150 mg ORAL ANDA 11 sections
Ranitidine HUMAN OTC DRUG LABEL 1 11673-849 TABLET, COATED 150 mg ORAL ANDA 14 sections
Acid Reducer HUMAN OTC DRUG LABEL 1 15127-340 TABLET 150 mg ORAL ANDA 14 sections
Ranitidine Hydrochloride HUMAN OTC DRUG LABEL 1 15127-711 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
RANITIDINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-200 TABLET 150 mg ORAL ANDA 10 sections
RANITIDINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-381 TABLET 300 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 17856-0664 SOLUTION 15 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 17856-0727 SOLUTION 15 mg ORAL ANDA 24 sections
Acid Reducer HUMAN OTC DRUG LABEL 1 21130-003 TABLET, FILM COATED 75 mg ORAL ANDA 14 sections
Acid Reducer 150 HUMAN OTC DRUG LABEL 1 21130-404 TABLET, COATED 150 mg ORAL ANDA 14 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 21695-109 TABLET 150 mg ORAL ANDA 10 sections
Ranitidine HUMAN PRESCRIPTION DRUG LABEL 1 21695-110 TABLET 300 mg ORAL ANDA 10 sections
Ranitidine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-337 CAPSULE 150 mg ORAL ANDA 24 sections