roxatidine acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2408 | 78628-28-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a histamine H2 receptor antagonist drug used to treat gastric ulcers
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.15 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| S (Water solubility) | 77 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1986 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BA06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) H2-receptor antagonists |
| MeSH PA | D000897 | Anti-Ulcer Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006635 | Histamine H2 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Zollinger-Ellison syndrome | indication | 53132006 | DOID:0050782 |
| Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
| Gastric ulcer | indication | 397825006 | DOID:10808 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.6 | acidic |
| pKa2 | 8.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H2 receptor | GPCR | ANTAGONIST | Kd | 7.60 | WOMBAT-PK | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 4025268 | VUID |
| N0000179233 | NUI |
| D01467 | KEGG_DRUG |
| 4025267 | VANDF |
| 4025268 | VANDF |
| C0073601 | UMLSCUI |
| CHEBI:94758 | CHEBI |
| CHEMBL46102 | ChEMBL_ID |
| DB08806 | DRUGBANK_ID |
| C053742 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5105 | PUBCHEM_CID |
| 93793-83-0 | SECONDARY_CAS_RN |
| ZUP3LSD0DO | UNII |
| 114817 | RXNORM |
| 006256 | NDDF |
| 006257 | NDDF |
| 006258 | NDDF |
| 699481007 | SNOMEDCT_US |
| 699482000 | SNOMEDCT_US |
| C0378091 | UMLSCUI |
| CHEMBL2104871 | ChEMBL_ID |
| CHEMBL4802233 | ChEMBL_ID |
| 5830 | INN_ID |
| 78273-80-0 | SECONDARY_CAS_RN |
| 91276 | PUBCHEM_CID |
| IV9VHT3YUM | UNII |
Pharmaceutical products:
None