niperotidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 4002 84845-75-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piperonyl ranitidine hydrochloride
  • niperotidine hydrochloride
  • niperotidine
  • piperonyl ranitidine HCl
  • niperotidine HCl
  • perultid
  • Molecular weight: 434.51
  • Formula: C20H26N4O5S
  • CLOGP: 2.39
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 2
  • TPSA: 102.04
  • ALOGS: -4
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
H2-receptor antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic
pKa2 3.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H2 receptor GPCR ANTAGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D07072 KEGG_DRUG
C0650638 UMLSCUI
CHEBI:135706 CHEBI
CHEMBL1909284 ChEMBL_ID
CHEMBL4297186 ChEMBL_ID
DB13760 DRUGBANK_ID
C073716 MESH_SUPPLEMENTAL_RECORD_UI
5857 INN_ID
12JBD7U72K UNII
3033952 PUBCHEM_CID

Pharmaceutical products:

None