hyaluronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3957	9004-61-9

Description:

Molecule	Description
Synonyms: hyaluronate sodium hyaluronic acid hyaluronate	A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA. Molecular weight: Formula: (C14H21NO12)n CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

hyaluronate sodium
hyaluronic acid
hyaluronate

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

Molecular weight:
Formula: (C14H21NO12)n
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3.60	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sensitisation	312.77	16.73	77	9164	3309	63476472
Polycystic ovaries	291.52	16.73	77	9164	4394	63475387
Rhinitis allergic	233.69	16.73	81	9160	11646	63468135
Ejection fraction	218.57	16.73	54	9187	2352	63477429
Sleep disorder due to a general medical condition	207.88	16.73	75	9166	12113	63467668
Blood test abnormal	203.85	16.73	79	9162	15550	63464231
Carpal tunnel syndrome	188.52	16.73	81	9160	20736	63459045
Ejection fraction abnormal	182.17	16.73	44	9197	1741	63478040
Burning sensation	164.52	16.73	101	9140	54306	63425475
Hypothyroidism	151.94	16.73	88	9153	42544	63437237
Sleep apnoea syndrome	144.98	16.73	75	9166	29058	63450723
Cardiac disorder	140.16	16.73	89	9152	50727	63429054
Renal disorder	133.49	16.73	74	9167	32900	63446881
Nephrectomy	132.71	16.73	33	9208	1475	63478306
Toxic anterior segment syndrome	117.79	16.73	31	9210	1740	63478041
Product preparation error	105.76	16.73	38	9203	6054	63473727
Gastrooesophageal reflux disease	92.22	16.73	90	9151	95549	63384232
Fibromyalgia	83.79	16.73	79	9162	80341	63399440
Asthma	70.90	16.73	90	9151	127471	63352310
Keratopathy	67.05	16.73	16	9225	600	63479181
Eyelid ptosis	61.57	16.73	27	9214	7240	63472541
Therapeutic product effect incomplete	61.37	16.73	83	9158	124973	63354808
Wheezing	58.81	16.73	71	9170	95524	63384257
Full blood count abnormal	53.23	16.73	41	9200	31676	63448105
Loss of personal independence in daily activities	53.01	16.73	68	9173	97222	63382559
Eye swelling	51.64	16.73	36	9205	23882	63455899
Off label use	50.88	16.73	213	9028	674249	62805532
Retinal vasculitis	50.45	16.73	14	9227	960	63478821
Swelling face	42.08	16.73	49	9192	63426	63416355
Facial paresis	36.27	16.73	15	9226	3483	63476298
Vision blurred	36.22	16.73	55	9186	91869	63387912
Hypertension	35.51	16.73	105	9136	279198	63200583
Facial pain	35.46	16.73	21	9220	10540	63469241
Headache	35.13	16.73	183	9058	633058	62846723
Brow ptosis	33.34	16.73	8	9233	307	63479474
Drug intolerance	31.34	16.73	4	9237	308657	63171124
Corneal opacity	30.91	16.73	9	9232	734	63479047
Facial asymmetry	30.19	16.73	9	9232	796	63478985
Corneal erosion	28.52	16.73	7	9234	296	63479485
Anxiety disorder	27.81	16.73	13	9228	4037	63475744
Eye pain	27.36	16.73	29	9212	33825	63445956
Strabismus	25.60	16.73	10	9231	2004	63477777
Nephropathy	25.00	16.73	14	9227	6327	63473454
Injection site mass	24.69	16.73	21	9220	18635	63461146
Endophthalmitis	23.04	16.73	11	9230	3581	63476200
Hypoaesthesia eye	22.98	16.73	6	9235	326	63479455
Injection site nodule	22.35	16.73	11	9230	3824	63475957
Lip swelling	22.30	16.73	25	9216	31038	63448743
Hospitalisation	21.73	16.73	42	9199	85039	63394742
Repetitive strain injury	21.54	16.73	5	9236	166	63479615
Ocular discomfort	21.33	16.73	11	9230	4222	63475559
Lip disorder	21.17	16.73	8	9233	1466	63478315
Vascular occlusion	20.56	16.73	7	9234	950	63478831
Glaucoma	20.48	16.73	19	9222	18886	63460895
Nasal cyst	20.39	16.73	4	9237	58	63479723
Hepatic enzyme increased	19.64	16.73	3	9238	202325	63277456
Cataract	19.50	16.73	32	9209	57021	63422760
Haemorrhagic vasculitis	19.04	16.73	4	9237	83	63479698
Ocular pemphigoid	18.48	16.73	4	9237	96	63479685
Eye inflammation	18.45	16.73	11	9230	5588	63474193
Systemic lupus erythematosus	18.33	16.73	4	9237	208914	63270867
Oral mucosal discolouration	17.83	16.73	5	9236	356	63479425
Dermatitis atopic	17.25	16.73	13	9228	9711	63470070
Neuromuscular toxicity	16.74	16.73	4	9237	151	63479630

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	60.72	23.40	14	2016	1155	34953746
Iris hypopigmentation	47.67	23.40	7	2023	42	34954859
Keratopathy	45.93	23.40	10	2020	635	34954266
Corneal opacity	41.25	23.40	9	2021	577	34954324
Pupillary disorder	28.60	23.40	6	2024	319	34954582
Cataract	28.07	23.40	18	2012	26168	34928733
Tumour pain	25.97	23.40	7	2023	1090	34953811
Visual acuity reduced	24.83	23.40	14	2016	16135	34938766

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sensitisation	273.47	16.17	67	10049	3244	79731028
Polycystic ovaries	264.68	16.17	67	10049	3712	79730560
Rhinitis allergic	209.72	16.17	73	10043	12196	79722076
Ejection fraction	177.68	16.17	44	10072	2225	79732047
Ejection fraction abnormal	174.51	16.17	44	10072	2396	79731876
Blood test abnormal	169.77	16.17	69	10047	17641	79716631
Sleep disorder due to a general medical condition	169.74	16.17	65	10051	14212	79720060
Toxic anterior segment syndrome	169.06	16.17	44	10072	2720	79731552
Carpal tunnel syndrome	163.26	16.17	69	10047	19459	79714813
Burning sensation	139.67	16.17	89	10027	58543	79675729
Nephrectomy	126.12	16.17	33	10083	2082	79732190
Sleep apnoea syndrome	114.22	16.17	66	10050	36412	79697860
Hypothyroidism	106.41	16.17	72	10044	52320	79681952
Keratopathy	102.84	16.17	25	10091	1169	79733103
Cardiac disorder	102.71	16.17	77	10039	65680	79668592
Product preparation error	101.01	16.17	35	10081	5758	79728514
Renal disorder	100.45	16.17	64	10052	42041	79692231
Fibromyalgia	86.64	16.17	69	10047	64271	79670001
Gastrooesophageal reflux disease	75.64	16.17	79	10037	104167	79630105
Asthma	59.05	16.17	79	10037	135016	79599256
Retinal vasculitis	56.74	16.17	16	10100	1337	79732935
Eyelid ptosis	51.38	16.17	26	10090	11018	79723254
Loss of personal independence in daily activities	49.50	16.17	63	10053	102517	79631755
Wheezing	49.11	16.17	67	10049	116597	79617675
Therapeutic product effect incomplete	48.87	16.17	74	10042	141571	79592701
Eye swelling	43.54	16.17	32	10084	26436	79707836
Corneal erosion	43.40	16.17	10	10106	370	79733902
Vision blurred	43.34	16.17	60	10056	105838	79628434
Endophthalmitis	41.65	16.17	19	10097	6409	79727863
Iris hypopigmentation	39.80	16.17	7	10109	62	79734210
Cataract	37.91	16.17	43	10073	62077	79672195
Ocular pemphigoid	33.38	16.17	7	10109	166	79734106
Swelling face	33.18	16.17	43	10073	71169	79663103
Glaucoma	32.75	16.17	24	10092	19737	79714535
Facial asymmetry	31.19	16.17	9	10107	817	79733455
Eye pain	29.98	16.17	30	10086	37548	79696724
Full blood count abnormal	29.91	16.17	31	10085	40443	79693829
Headache	29.71	16.17	162	9954	653610	79080662
Visual acuity reduced	28.19	16.17	26	10090	29443	79704829
Ulcerative keratitis	27.41	16.17	12	10104	3677	79730595
Hypertension	27.21	16.17	98	10018	330894	79403378
Brow ptosis	26.34	16.17	6	10110	211	79734061
Blepharitis	25.96	16.17	11	10105	3113	79731159
Facial paresis	25.67	16.17	13	10103	5513	79728759
Facial pain	25.11	16.17	17	10099	12333	79721939
Pupillary disorder	25.01	16.17	7	10109	569	79733703
Hypoaesthesia eye	24.86	16.17	6	10110	272	79734000
Strabismus	24.75	16.17	10	10106	2511	79731761
Corneal oedema	24.38	16.17	10	10106	2610	79731662
Vitreous opacities	23.91	16.17	7	10109	668	79733604
Repetitive strain injury	22.65	16.17	5	10111	152	79734120
Nasal cyst	22.31	16.17	4	10112	40	79734232
Product contamination physical	22.20	16.17	5	10111	167	79734105
Toxicity to various agents	22.17	16.17	13	10103	421527	79312745
Lip disorder	21.93	16.17	8	10108	1526	79732746
Erythema	21.74	16.17	70	10046	223220	79511052
Hospitalisation	21.53	16.17	41	10075	94195	79640077
Nephropathy	21.23	16.17	14	10102	9724	79724548
Off label use	21.14	16.17	191	9925	907024	78827248
Lip swelling	21.11	16.17	26	10090	40885	79693387
Corneal opacity	21.07	16.17	7	10109	1013	79733259
Injection site nodule	20.86	16.17	10	10106	3770	79730502
Conjunctival bleb	19.23	16.17	4	10112	91	79734181
Anterior chamber pigmentation	19.09	16.17	3	10113	12	79734260
Haemorrhagic vasculitis	18.72	16.17	4	10112	104	79734168
Oral mucosal discolouration	18.58	16.17	5	10111	351	79733921
Ocular discomfort	18.25	16.17	10	10106	4973	79729299
Injection site mass	17.75	16.17	17	10099	20167	79714105
Punctate keratitis	17.35	16.17	6	10110	980	79733292
Hypotension	16.44	16.17	19	10097	440298	79293974

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D03AX05	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	M09AX01	MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Other drugs for disorders of the musculo-skeletal system
ATC	R01AX09	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	S01KA01	SENSORY ORGANS OPHTHALMOLOGICALS SURGICAL AIDS Viscoelastic substances
ATC	S01KA51	SENSORY ORGANS OPHTHALMOLOGICALS SURGICAL AIDS Viscoelastic substances
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D007155	Immunologic Factors
MeSH PA	D020011	Protective Agents
MeSH PA	D055675	Viscosupplements
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Surgical procedure on eye proper	indication	373353005
Operation on lens	indication	386612009
Glaucoma	contraindication	23986001	DOID:1686

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Joint dysfunction caused by noninfectious synovitis associated with osteoarthritis	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Hylartin V, Hylartin V Injection	Zoetis Inc.	1
Hyvisc	Anika Therapeutics	1
Equron	Zoetis Inc.	1
Synacid	Intervet Inc.	1
Hyalovet	Boehringer lngelheim Animal Health USA Inc.	1
Legend Injectable Solution, Legend Multi Dose	Boehringer lngelheim Animal Health USA Inc.	1
NexHA	Vetoquinol USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019426	VUID
N0000147557	NUI
D08043	KEGG_DRUG
9067-32-7	SECONDARY_CAS_RN
4019426	VANDF
4020205	VANDF
C0020196	UMLSCUI
CHEBI:16336	CHEBI
CHEMBL2110674	ChEMBL_ID
CHEMBL1697748	ChEMBL_ID
CHEMBL4594244	ChEMBL_ID
D006820	MESH_DESCRIPTOR_UI
DB08818	DRUGBANK_ID
S270N0TRQY	UNII
42892	RXNORM
119505	MMSL
18314	MMSL
26653	MMSL
5484	MMSL
d04329	MMSL
d05234	MMSL
002239	NDDF
006663	NDDF
015689	NDDF
38218009	SNOMEDCT_US
387578003	SNOMEDCT_US
96278006	SNOMEDCT_US
3084049	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ginsamin Beauty	HUMAN OTC DRUG LABEL	4	44738-6001	GRANULE	60 mg	ORAL	unapproved drug other	6 sections
Cotta	HUMAN OTC DRUG LABEL	3	58748-001	FILM, EXTENDED RELEASE	0.30 g	TOPICAL	unapproved drug other	8 sections
MAXCLINIC HYALURONIC MESO CHANGE ROLLER	HUMAN OTC DRUG LABEL	1	69058-400	PATCH	67.90 mg	TOPICAL	unapproved drug other	8 sections
MAXCLINIC HYALURONIC MESO CHANGEROLLER	HUMAN OTC DRUG LABEL	1	69058-600	PATCH	67.90 mg	TOPICAL	unapproved drug other	8 sections
WELLAGE FAMILY MASK SMALL	HUMAN OTC DRUG LABEL	1	69346-0001	PATCH	0.06 g	TOPICAL	unapproved drug other	7 sections
WELLAGE FAMILY MASK LARGE	HUMAN OTC DRUG LABEL	1	69346-0008	PATCH	0.06 g	TOPICAL	unapproved drug other	7 sections
WELLAGE Hyaluronic Acid Micro Needle	HUMAN OTC DRUG LABEL	1	69346-9001	PATCH	99 g	TOPICAL	unapproved drug other	8 sections
Clapiel Hyalon Serum	HUMAN OTC DRUG LABEL	2	69977-020	CREAM	10.50 mg	TOPICAL	unapproved drug other	8 sections
Hyaluronic Acid Micro	HUMAN OTC DRUG LABEL	1	70018-010	PATCH	1.14 g	TOPICAL	unapproved drug other	8 sections
Ramosu Hyaluronic Acid Solution 100	HUMAN OTC DRUG LABEL	1	70465-0003	LIQUID	100 g	TOPICAL	unapproved drug other	6 sections
Im Fill	HUMAN OTC DRUG LABEL	1	70514-0009	PATCH	99.97 g	TOPICAL	unapproved drug other	7 sections
Hyaluronic Acid Gel	HUMAN OTC DRUG LABEL	1	70663-001	GEL	3.50 mg	TOPICAL	unapproved drug other	12 sections
Hyaluronic Acid Gel	HUMAN OTC DRUG LABEL	1	70663-005	GEL	3.50 mg	TOPICAL	unapproved drug other	12 sections
XR CELLULAR MAGIC	HUMAN OTC DRUG LABEL	1	70663-008	GEL	0.10 mg	TOPICAL	unapproved drug other	10 sections
DEEPAIR MICRO INTENSIVE MAGIC	HUMAN OTC DRUG LABEL	1	70961-0001	PATCH	6.10 g	TOPICAL	unapproved drug other	7 sections
PRO PH Filler	HUMAN OTC DRUG LABEL	1	71066-0002	GEL	1000 g	TOPICAL	unapproved drug other	5 sections
HARUTO BEAUTY MICRONEEDLE ACNE PIMPLEPATCH	HUMAN OTC DRUG LABEL	1	71184-0002	PATCH	0.43 mg	TOPICAL	unapproved drug other	7 sections
KAEWOON FOR MEN	HUMAN OTC DRUG LABEL	2	71237-003	GEL	20 mg	TOPICAL	unapproved drug other	8 sections
KAEWOON FOR WOMEN	HUMAN OTC DRUG LABEL	2	71237-004	GEL	20 mg	TOPICAL	unapproved drug other	8 sections
HYALURON 3S SERUM	HUMAN OTC DRUG LABEL	1	71276-140	CREAM	0.15 g	TOPICAL	unapproved drug other	8 sections
Le-Blen EGF Serum	HUMAN OTC DRUG LABEL	2	72271-100	LOTION	0.40 g	TOPICAL	unapproved drug other	7 sections
Le-Blen FGF Serum	HUMAN OTC DRUG LABEL	3	72271-101	EMULSION	0.40 g	TOPICAL	unapproved drug other	8 sections
Le-Blen Nano Collagen Peptide Serum	HUMAN OTC DRUG LABEL	3	72271-102	LOTION	0.54 g	TOPICAL	unapproved drug other	8 sections
Le-Blen Vitamin C Serum	HUMAN OTC DRUG LABEL	2	72271-103	LOTION	2.84 g	TOPICAL	unapproved drug other	8 sections
Miracle Aqua Peeling	HUMAN OTC DRUG LABEL	1	72557-001	GEL	0.01 g	TOPICAL	unapproved drug other	8 sections
Miracle Laser Mask	HUMAN OTC DRUG LABEL	1	72557-005	CREAM	0.00 g	TOPICAL	unapproved drug other	8 sections
DR.PLINUS FILLINCELL MULTI	HUMAN OTC DRUG LABEL	3	72630-020	PATCH	0.21 g	TOPICAL	unapproved drug other	10 sections
DR.PLINUS FILLINCELL MULTI	HUMAN OTC DRUG LABEL	3	72630-020	PATCH	0.21 g	TOPICAL	unapproved drug other	10 sections
ELCOSYS	HUMAN OTC DRUG LABEL	1	72910-0001	PATCH	99.97 mg	TOPICAL	unapproved drug other	7 sections
PokePoke Patch	HUMAN OTC DRUG LABEL	1	72910-0002	PATCH	94.39 mg	TOPICAL	unapproved drug other	7 sections