hyaluronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3957 9004-61-9

Description:

MoleculeDescription

Synonyms:

  • hyaluronate sodium
  • hyaluronic acid
  • hyaluronate
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
  • Molecular weight:
  • Formula: (C14H21NO12)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.60 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product preparation error 106.81 17.40 34 6341 4338 50594411
Toxic anterior segment syndrome 106.08 17.40 27 6348 1538 50597211
Sensitisation 96.04 17.40 25 6350 1557 50597192
Polycystic ovaries 84.88 17.40 25 6350 2459 50596290
Off label use 80.50 17.40 181 6194 474245 50124504
Keratopathy 73.74 17.40 16 6359 452 50598297
Rhinitis allergic 72.45 17.40 29 6346 7171 50591578
Eyelid ptosis 66.02 17.40 26 6349 6161 50592588
Burning sensation 55.71 17.40 46 6329 45400 50553349
Ejection fraction 54.13 17.40 15 6360 1185 50597564
Sleep disorder due to a general medical condition 51.79 17.40 23 6352 7348 50591401
Eye swelling 51.71 17.40 32 6343 20112 50578637
Retinal vasculitis 49.69 17.40 13 6362 825 50597924
Ejection fraction abnormal 49.55 17.40 13 6362 834 50597915
Carpal tunnel syndrome 48.94 17.40 29 6346 16864 50581885
Blood test abnormal 48.07 17.40 25 6350 11294 50587455
Swelling face 46.04 17.40 44 6331 52551 50546198
Nephrectomy 44.96 17.40 12 6363 823 50597926
Vision blurred 44.26 17.40 52 6323 78595 50520154
Facial pain 41.75 17.40 20 6355 7589 50591160
Hypothyroidism 40.68 17.40 34 6341 34091 50564658
Facial paresis 36.29 17.40 14 6361 3138 50595611
Brow ptosis 35.72 17.40 8 6367 262 50598487
Hypoaesthesia eye 32.58 17.40 6 6369 71 50598678
Sleep apnoea syndrome 31.00 17.40 25 6350 23843 50574906
Anxiety disorder 30.84 17.40 13 6362 3660 50595089
Eye pain 29.15 17.40 26 6349 28423 50570326
Facial asymmetry 28.55 17.40 8 6367 658 50598091
Injection site mass 28.30 17.40 20 6355 15660 50583089
Glaucoma 26.00 17.40 19 6356 15667 50583082
Corneal erosion 25.65 17.40 6 6369 239 50598510
Injection site nodule 25.30 17.40 11 6364 3337 50595412
Dermatitis atopic 24.58 17.40 11 6364 3575 50595174
Corneal opacity 24.18 17.40 7 6368 647 50598102
Lip swelling 24.14 17.40 22 6353 24714 50574035
Repetitive strain injury 22.59 17.40 5 6370 155 50598594
Renal disorder 22.16 17.40 22 6353 27483 50571266
Ocular discomfort 22.02 17.40 10 6365 3363 50595386
Cardiac disorder 21.83 17.40 27 6348 42952 50555797
Erythema 21.48 17.40 53 6322 146361 50452388
Nasal cyst 21.16 17.40 4 6371 55 50598694
Fibromyalgia 20.86 17.40 27 6348 44951 50553798
Haemorrhagic vasculitis 20.31 17.40 4 6371 69 50598680
Lip disorder 19.91 17.40 7 6368 1210 50597539
Head discomfort 19.76 17.40 14 6361 11005 50587744
Vascular occlusion 18.53 17.40 6 6369 807 50597942
Neuromuscular toxicity 17.52 17.40 4 6371 143 50598606

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 51.78 23.12 12 1687 1024 29571804
Keratopathy 51.37 23.12 10 1689 368 29572460
Iris hypopigmentation 47.75 23.12 7 1692 42 29572786
Corneal opacity 36.88 23.12 8 1691 505 29572323
Pupillary disorder 29.77 23.12 6 1693 264 29572564
Ulcerative keratitis 24.25 23.12 7 1692 1416 29571412
Visual acuity reduced 23.29 23.12 13 1686 14863 29557965

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 149.08 16.32 38 7347 2401 64488946
Keratopathy 116.00 16.32 25 7360 755 64490592
Product preparation error 100.15 16.32 31 7354 3974 64487373
Sensitisation 96.17 16.32 25 7360 1706 64489641
Polycystic ovaries 90.75 16.32 25 7360 2130 64489217
Rhinitis allergic 75.36 16.32 30 7355 8048 64483299
Retinal vasculitis 56.22 16.32 15 7370 1132 64490215
Ejection fraction 54.52 16.32 15 7370 1271 64490076
Eyelid ptosis 54.43 16.32 25 7360 9500 64481847
Burning sensation 51.82 16.32 44 7341 49620 64441727
Sleep disorder due to a general medical condition 51.45 16.32 23 7362 8211 64483136
Carpal tunnel syndrome 47.79 16.32 27 7358 15801 64475546
Vision blurred 47.39 16.32 55 7330 90261 64401086
Blood test abnormal 47.16 16.32 25 7360 12918 64478429
Eye swelling 46.54 16.32 30 7355 22251 64469096
Ejection fraction abnormal 44.20 16.32 13 7372 1400 64489947
Iris hypopigmentation 41.61 16.32 7 7378 52 64491295
Off label use 41.36 16.32 162 7223 632644 63858703
Corneal erosion 41.07 16.32 9 7376 294 64491053
Nephrectomy 39.77 16.32 12 7373 1410 64489937
Swelling face 37.88 16.32 40 7345 59126 64432221
Glaucoma 36.60 16.32 23 7362 16325 64475022
Hypoaesthesia eye 32.49 16.32 6 7379 80 64491267
Cataract 31.65 16.32 34 7351 51228 64440119
Eye pain 30.90 16.32 27 7358 31598 64459749
Facial pain 30.90 16.32 16 7369 7879 64483468
Endophthalmitis 30.40 16.32 14 7371 5351 64485996
Visual acuity reduced 30.27 16.32 25 7360 27116 64464231
Sleep apnoea syndrome 30.22 16.32 26 7359 29806 64461541
Erythema 29.83 16.32 66 7319 187004 64304343
Blepharitis 29.20 16.32 11 7374 2544 64488803
Facial asymmetry 28.92 16.32 8 7377 691 64490656
Hypothyroidism 28.87 16.32 29 7356 40428 64450919
Fibromyalgia 28.08 16.32 27 7358 35704 64455643
Brow ptosis 28.03 16.32 6 7379 175 64491172
Pupillary disorder 27.38 16.32 7 7378 447 64490900
Ulcerative keratitis 27.14 16.32 11 7374 3086 64488261
Facial paresis 25.34 16.32 12 7373 4880 64486467
Ocular pemphigoid 25.07 16.32 5 7380 102 64491245
Lip swelling 24.86 16.32 24 7361 31883 64459464
Product contamination physical 24.34 16.32 5 7380 119 64491228
Repetitive strain injury 23.36 16.32 5 7380 146 64491201
Injection site nodule 23.35 16.32 10 7375 3220 64488127
Nasal cyst 22.81 16.32 4 7381 39 64491308
Lip disorder 20.32 16.32 7 7378 1254 64490093
Haemorrhagic vasculitis 19.81 16.32 4 7381 87 64491260
Injection site mass 19.44 16.32 16 7369 17254 64474093
Corneal oedema 19.43 16.32 8 7377 2335 64489012
Anterior chamber pigmentation 19.40 16.32 3 7382 12 64491335
Renal disorder 19.31 16.32 22 7363 35343 64456004
Product deposit 18.52 16.32 5 7380 394 64490953
Corneal opacity 18.46 16.32 6 7379 899 64490448
Ocular discomfort 18.27 16.32 9 7376 3990 64487357
Injection site swelling 18.11 16.32 23 7362 41330 64450017
Conjunctival bleb 17.64 16.32 3 7382 24 64491323
Dry eye 17.47 16.32 19 7366 29000 64462347
Toxicity to various agents 17.43 16.32 10 7375 363503 64127844
Asthma 16.76 16.32 35 7350 95190 64396157
Strabismus 16.72 16.32 7 7378 2130 64489217

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D03AX05 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC M09AX01 MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
Other drugs for disorders of the musculo-skeletal system
ATC R01AX09 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01KA01 SENSORY ORGANS
OPHTHALMOLOGICALS
SURGICAL AIDS
Viscoelastic substances
ATC S01KA51 SENSORY ORGANS
OPHTHALMOLOGICALS
SURGICAL AIDS
Viscoelastic substances
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D007155 Immunologic Factors
MeSH PA D020011 Protective Agents
MeSH PA D055675 Viscosupplements
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Surgical procedure on eye proper indication 373353005
Operation on lens indication 386612009
Glaucoma contraindication 23986001 DOID:1686




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Joint dysfunction caused by noninfectious synovitis associated with osteoarthritis Indication

🐶 Veterinary products

ProductApplicantIngredients
Hylartin V, Hylartin V Injection Zoetis Inc. 1
Hyvisc Anika Therapeutics 1
Equron Zoetis Inc. 1
Synacid Intervet Inc. 1
Hyalovet Boehringer lngelheim Animal Health USA Inc. 1
Legend Injectable Solution, Legend Multi Dose Boehringer lngelheim Animal Health USA Inc. 1
NexHA Vetoquinol USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019426 VUID
N0000147557 NUI
D08043 KEGG_DRUG
9067-32-7 SECONDARY_CAS_RN
4019426 VANDF
4020205 VANDF
C0020196 UMLSCUI
CHEBI:16336 CHEBI
CHEMBL2110674 ChEMBL_ID
CHEMBL1697748 ChEMBL_ID
CHEMBL4594244 ChEMBL_ID
CHEMBL2105008 ChEMBL_ID
D006820 MESH_DESCRIPTOR_UI
DB08818 DRUGBANK_ID
S270N0TRQY UNII
42892 RXNORM
119505 MMSL
18314 MMSL
26653 MMSL
5484 MMSL
d04329 MMSL
d05234 MMSL
002239 NDDF
006663 NDDF
015689 NDDF
38218009 SNOMEDCT_US
387578003 SNOMEDCT_US
96278006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ginsamin Beauty HUMAN OTC DRUG LABEL 4 44738-6001 GRANULE 60 mg ORAL unapproved drug other 3 sections
Cotta HUMAN OTC DRUG LABEL 3 58748-001 FILM, EXTENDED RELEASE 0.30 g TOPICAL unapproved drug other 8 sections
MAXCLINIC HYALURONIC MESO CHANGE ROLLER HUMAN OTC DRUG LABEL 1 69058-400 PATCH 67.90 mg TOPICAL unapproved drug other 8 sections
MAXCLINIC HYALURONIC MESO CHANGEROLLER HUMAN OTC DRUG LABEL 1 69058-600 PATCH 67.90 mg TOPICAL unapproved drug other 8 sections
WELLAGE FAMILY MASK SMALL HUMAN OTC DRUG LABEL 1 69346-0001 PATCH 0.06 g TOPICAL unapproved drug other 7 sections
WELLAGE FAMILY MASK LARGE HUMAN OTC DRUG LABEL 1 69346-0008 PATCH 0.06 g TOPICAL unapproved drug other 7 sections
WELLAGE Hyaluronic Acid Micro Needle HUMAN OTC DRUG LABEL 1 69346-9001 PATCH 99 g TOPICAL unapproved drug other 8 sections
Clapiel Hyalon Serum HUMAN OTC DRUG LABEL 2 69977-020 CREAM 10.50 mg TOPICAL unapproved drug other 8 sections
Hyaluronic Acid Micro HUMAN OTC DRUG LABEL 1 70018-010 PATCH 1.14 g TOPICAL unapproved drug other 8 sections
Ramosu Hyaluronic Acid Solution 100 HUMAN OTC DRUG LABEL 1 70465-0003 LIQUID 100 g TOPICAL unapproved drug other 6 sections
Im Fill HUMAN OTC DRUG LABEL 1 70514-0009 PATCH 99.97 g TOPICAL unapproved drug other 7 sections
Hyaluronic Acid Gel HUMAN OTC DRUG LABEL 1 70663-001 GEL 3.50 mg TOPICAL unapproved drug other 12 sections
Hyaluronic Acid Gel HUMAN OTC DRUG LABEL 1 70663-005 GEL 3.50 mg TOPICAL unapproved drug other 12 sections
XR CELLULAR MAGIC HUMAN OTC DRUG LABEL 1 70663-008 GEL 0.10 mg TOPICAL unapproved drug other 10 sections
DEEPAIR MICRO INTENSIVE MAGIC HUMAN OTC DRUG LABEL 1 70961-0001 PATCH 6.10 g TOPICAL unapproved drug other 7 sections
PRO PH Filler HUMAN OTC DRUG LABEL 1 71066-0002 GEL 1000 g TOPICAL unapproved drug other 5 sections
HARUTO BEAUTY MICRONEEDLE ACNE PIMPLEPATCH HUMAN OTC DRUG LABEL 1 71184-0002 PATCH 0.43 mg TOPICAL unapproved drug other 7 sections
KAEWOON FOR MEN HUMAN OTC DRUG LABEL 2 71237-003 GEL 20 mg TOPICAL unapproved drug other 8 sections
KAEWOON FOR WOMEN HUMAN OTC DRUG LABEL 2 71237-004 GEL 20 mg TOPICAL unapproved drug other 8 sections
HYALURON 3S SERUM HUMAN OTC DRUG LABEL 1 71276-140 CREAM 0.15 g TOPICAL unapproved drug other 8 sections
Le-Blen EGF Serum HUMAN OTC DRUG LABEL 2 72271-100 LOTION 0.40 g TOPICAL unapproved drug other 7 sections
Le-Blen FGF Serum HUMAN OTC DRUG LABEL 3 72271-101 EMULSION 0.40 g TOPICAL unapproved drug other 8 sections
Le-Blen Nano Collagen Peptide Serum HUMAN OTC DRUG LABEL 3 72271-102 LOTION 0.54 g TOPICAL unapproved drug other 8 sections
Le-Blen Vitamin C Serum HUMAN OTC DRUG LABEL 2 72271-103 LOTION 2.84 g TOPICAL unapproved drug other 8 sections
Miracle Aqua Peeling HUMAN OTC DRUG LABEL 1 72557-001 GEL 0.01 g TOPICAL unapproved drug other 8 sections
Miracle Laser Mask HUMAN OTC DRUG LABEL 1 72557-005 CREAM 0.00 g TOPICAL unapproved drug other 8 sections
DR.PLINUS FILLINCELL MULTI HUMAN OTC DRUG LABEL 3 72630-020 PATCH 0.21 g TOPICAL unapproved drug other 10 sections
ELCOSYS HUMAN OTC DRUG LABEL 1 72910-0001 PATCH 99.97 mg TOPICAL unapproved drug other 7 sections
PokePoke Patch HUMAN OTC DRUG LABEL 1 72910-0002 PATCH 94.39 mg TOPICAL unapproved drug other 7 sections
FUNEES HUMAN OTC DRUG LABEL 1 72910-0003 PATCH 6.14 g TOPICAL unapproved drug other 7 sections