Stem definition | Drug id | CAS RN |
---|---|---|
proteasome inhibitors | 391 | 179324-69-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.30 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.08 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.17 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 14, 2019 | EMA | FRESENIUS KABI DEUTSCHLAND GMBH | |
Aug. 22, 2019 | PMDA | Janssen Pharmaceutical K.K. | |
May 13, 2003 | FDA | MILLENNIUM PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Plasma cell myeloma | 6090.51 | 13.42 | 2199 | 61534 | 44447 | 56183887 |
Neuropathy peripheral | 2397.94 | 13.42 | 1474 | 62259 | 101419 | 56126915 |
Thrombocytopenia | 594.84 | 13.42 | 751 | 62982 | 135473 | 56092861 |
Plasma cell myeloma recurrent | 572.45 | 13.42 | 185 | 63548 | 2589 | 56225745 |
Platelet count decreased | 419.46 | 13.42 | 558 | 63175 | 105825 | 56122509 |
Rheumatoid arthritis | 407.32 | 13.42 | 5 | 63728 | 382599 | 55845735 |
Diarrhoea | 388.15 | 13.42 | 1585 | 62148 | 636922 | 55591412 |
Disease progression | 377.27 | 13.42 | 527 | 63206 | 104646 | 56123688 |
Plasmacytoma | 337.96 | 13.42 | 121 | 63612 | 2345 | 56225989 |
Polyneuropathy | 297.58 | 13.42 | 185 | 63548 | 12865 | 56215469 |
Constipation | 265.52 | 13.42 | 656 | 63077 | 201287 | 56027047 |
Pneumonia | 264.16 | 13.42 | 1033 | 62700 | 406065 | 55822269 |
Neutropenia | 263.29 | 13.42 | 564 | 63169 | 157603 | 56070731 |
Plasma cell leukaemia | 236.36 | 13.42 | 77 | 63656 | 1106 | 56227228 |
White blood cell count decreased | 219.69 | 13.42 | 458 | 63275 | 125532 | 56102802 |
Pancytopenia | 192.89 | 13.42 | 354 | 63379 | 88361 | 56139973 |
Contraindicated product administered | 191.39 | 13.42 | 4 | 63729 | 186282 | 56042052 |
Maternal exposure during pregnancy | 183.99 | 13.42 | 7 | 63726 | 189546 | 56038788 |
Arthralgia | 173.26 | 13.42 | 188 | 63545 | 501481 | 55726853 |
Drug hypersensitivity | 168.82 | 13.42 | 51 | 63682 | 275154 | 55953180 |
Full blood count decreased | 158.27 | 13.42 | 162 | 63571 | 23187 | 56205147 |
Headache | 153.75 | 13.42 | 248 | 63485 | 558796 | 55669538 |
Sepsis | 151.57 | 13.42 | 423 | 63310 | 139417 | 56088917 |
Glossodynia | 150.12 | 13.42 | 5 | 63728 | 152453 | 56075881 |
Tumour lysis syndrome | 145.36 | 13.42 | 98 | 63635 | 7825 | 56220509 |
Exposure during pregnancy | 139.72 | 13.42 | 3 | 63730 | 136339 | 56091995 |
Pain | 138.86 | 13.42 | 345 | 63388 | 662839 | 55565495 |
Anaemia | 128.56 | 13.42 | 621 | 63112 | 266890 | 55961444 |
Posterior reversible encephalopathy syndrome | 125.34 | 13.42 | 120 | 63613 | 15840 | 56212494 |
Amyloidosis | 123.88 | 13.42 | 47 | 63686 | 1078 | 56227256 |
Drug ineffective | 123.20 | 13.42 | 580 | 63153 | 918409 | 55309925 |
Therapeutic product effect decreased | 120.29 | 13.42 | 23 | 63710 | 169429 | 56058905 |
Unevaluable event | 120.02 | 13.42 | 203 | 63530 | 47484 | 56180850 |
Febrile neutropenia | 118.00 | 13.42 | 323 | 63410 | 105222 | 56123112 |
Laboratory test abnormal | 116.82 | 13.42 | 142 | 63591 | 24553 | 56203781 |
Cardiac amyloidosis | 115.88 | 13.42 | 41 | 63692 | 766 | 56227568 |
Peripheral sensory neuropathy | 115.70 | 13.42 | 81 | 63652 | 6875 | 56221459 |
Swelling | 113.89 | 13.42 | 65 | 63668 | 239706 | 55988628 |
Deep vein thrombosis | 112.67 | 13.42 | 261 | 63472 | 76716 | 56151618 |
Alopecia | 111.40 | 13.42 | 101 | 63632 | 293357 | 55934977 |
Arthropathy | 110.87 | 13.42 | 44 | 63689 | 200231 | 56028103 |
Dehydration | 108.99 | 13.42 | 411 | 63322 | 158414 | 56069920 |
Neutrophil count decreased | 103.44 | 13.42 | 195 | 63538 | 49627 | 56178707 |
Chalazion | 103.27 | 13.42 | 31 | 63702 | 334 | 56228000 |
Wound | 102.50 | 13.42 | 17 | 63716 | 138787 | 56089547 |
Abdominal discomfort | 102.20 | 13.42 | 98 | 63635 | 277176 | 55951158 |
Primary amyloidosis | 101.24 | 13.42 | 22 | 63711 | 50 | 56228284 |
Discomfort | 101.11 | 13.42 | 19 | 63714 | 141742 | 56086592 |
Pericarditis | 99.29 | 13.42 | 6 | 63727 | 108917 | 56119417 |
Plasma cell myeloma refractory | 98.46 | 13.42 | 21 | 63712 | 42 | 56228292 |
Condition aggravated | 98.39 | 13.42 | 149 | 63584 | 344749 | 55883585 |
Off label use | 97.08 | 13.42 | 1008 | 62725 | 555172 | 55673162 |
Septic shock | 96.51 | 13.42 | 213 | 63520 | 60622 | 56167712 |
Musculoskeletal stiffness | 93.61 | 13.42 | 30 | 63703 | 155977 | 56072357 |
Joint swelling | 90.81 | 13.42 | 117 | 63616 | 289683 | 55938651 |
Treatment failure | 90.16 | 13.42 | 40 | 63693 | 170352 | 56057982 |
Renal failure | 89.49 | 13.42 | 302 | 63431 | 110198 | 56118136 |
Cytopenia | 89.49 | 13.42 | 80 | 63653 | 9675 | 56218659 |
Product use in unapproved indication | 88.91 | 13.42 | 355 | 63378 | 140467 | 56087867 |
Hordeolum | 82.66 | 13.42 | 46 | 63687 | 2600 | 56225734 |
Light chain analysis increased | 81.54 | 13.42 | 35 | 63698 | 1114 | 56227220 |
Herpes zoster | 80.59 | 13.42 | 228 | 63505 | 75661 | 56152673 |
Therapy partial responder | 71.72 | 13.42 | 64 | 63669 | 7721 | 56220613 |
Overdose | 71.69 | 13.42 | 16 | 63717 | 105814 | 56122520 |
Hyperviscosity syndrome | 68.56 | 13.42 | 19 | 63714 | 150 | 56228184 |
Myelodysplastic syndrome | 67.50 | 13.42 | 88 | 63645 | 16318 | 56212016 |
Drug interaction | 67.42 | 13.42 | 83 | 63650 | 209672 | 56018662 |
Hypersensitivity | 67.21 | 13.42 | 117 | 63616 | 256291 | 55972043 |
Mobility decreased | 66.98 | 13.42 | 15 | 63718 | 98976 | 56129358 |
Monoclonal immunoglobulin present | 66.27 | 13.42 | 27 | 63706 | 752 | 56227582 |
Thrombosis | 65.50 | 13.42 | 181 | 63552 | 59246 | 56169088 |
Orthostatic hypotension | 65.28 | 13.42 | 127 | 63606 | 33072 | 56195262 |
Atrial fibrillation | 65.11 | 13.42 | 270 | 63463 | 108627 | 56119707 |
Helicobacter infection | 63.96 | 13.42 | 5 | 63728 | 73263 | 56155071 |
Injection site pain | 62.72 | 13.42 | 27 | 63706 | 117091 | 56111243 |
Protein total increased | 61.95 | 13.42 | 38 | 63695 | 2577 | 56225757 |
Hepatic enzyme increased | 61.44 | 13.42 | 62 | 63671 | 171322 | 56057012 |
Haemoglobin decreased | 60.43 | 13.42 | 306 | 63427 | 133831 | 56094503 |
Stem cell transplant | 59.12 | 13.42 | 32 | 63701 | 1712 | 56226622 |
Blister | 55.35 | 13.42 | 27 | 63706 | 108860 | 56119474 |
Autonomic neuropathy | 54.60 | 13.42 | 26 | 63707 | 1059 | 56227275 |
Cytomegalovirus infection reactivation | 52.86 | 13.42 | 37 | 63696 | 3139 | 56225195 |
Coombs indirect test positive | 52.82 | 13.42 | 12 | 63721 | 36 | 56228298 |
Pathological fracture | 52.77 | 13.42 | 55 | 63678 | 8034 | 56220300 |
Fibromyalgia | 52.21 | 13.42 | 4 | 63729 | 59599 | 56168735 |
Hepatitis B reactivation | 51.82 | 13.42 | 33 | 63700 | 2391 | 56225943 |
Haematotoxicity | 51.14 | 13.42 | 55 | 63678 | 8328 | 56220006 |
Folliculitis | 50.18 | 13.42 | 3 | 63730 | 54976 | 56173358 |
Ageusia | 48.47 | 13.42 | 65 | 63668 | 12386 | 56215948 |
Hypocalcaemia | 48.22 | 13.42 | 103 | 63630 | 28657 | 56199677 |
Wrong technique in product usage process | 48.00 | 13.42 | 5 | 63728 | 58163 | 56170171 |
Irritable bowel syndrome | 47.07 | 13.42 | 10 | 63723 | 68448 | 56159886 |
Cytomegalovirus infection | 47.02 | 13.42 | 81 | 63652 | 19215 | 56209119 |
Malignant neoplasm progression | 45.98 | 13.42 | 185 | 63548 | 73402 | 56154932 |
Ileus paralytic | 45.78 | 13.42 | 38 | 63695 | 4157 | 56224177 |
Suicide attempt | 45.17 | 13.42 | 6 | 63727 | 57830 | 56170504 |
Hypercalcaemia | 44.92 | 13.42 | 93 | 63640 | 25318 | 56203016 |
Bone marrow failure | 44.79 | 13.42 | 99 | 63634 | 28187 | 56200147 |
Pneumonia fungal | 44.63 | 13.42 | 40 | 63693 | 4853 | 56223481 |
Peripheral sensorimotor neuropathy | 44.21 | 13.42 | 24 | 63709 | 1291 | 56227043 |
Bone pain | 44.03 | 13.42 | 141 | 63592 | 50044 | 56178290 |
Migraine | 43.39 | 13.42 | 22 | 63711 | 86775 | 56141559 |
Pyrexia | 43.02 | 13.42 | 689 | 63044 | 418084 | 55810250 |
Endocarditis bacterial | 40.99 | 13.42 | 18 | 63715 | 606 | 56227728 |
Morganella infection | 40.23 | 13.42 | 18 | 63715 | 634 | 56227700 |
Syncope | 40.04 | 13.42 | 234 | 63499 | 107965 | 56120369 |
Mesenteric abscess | 39.90 | 13.42 | 11 | 63722 | 85 | 56228249 |
Cardiac failure | 39.59 | 13.42 | 191 | 63542 | 81902 | 56146432 |
Inappropriate antidiuretic hormone secretion | 39.25 | 13.42 | 62 | 63671 | 13694 | 56214640 |
Electrolyte imbalance | 39.18 | 13.42 | 72 | 63661 | 17961 | 56210373 |
Blood pressure increased | 39.14 | 13.42 | 65 | 63668 | 145111 | 56083223 |
Oedema peripheral | 38.47 | 13.42 | 328 | 63405 | 170926 | 56057408 |
Plasmablastic lymphoma | 38.32 | 13.42 | 14 | 63719 | 288 | 56228046 |
Peripheral motor neuropathy | 37.97 | 13.42 | 23 | 63710 | 1525 | 56226809 |
Osteolysis | 37.90 | 13.42 | 28 | 63705 | 2585 | 56225749 |
Large intestinal ulcer perforation | 37.51 | 13.42 | 10 | 63723 | 67 | 56228267 |
Anxiety | 37.50 | 13.42 | 104 | 63629 | 193068 | 56035266 |
Therapy non-responder | 37.33 | 13.42 | 153 | 63580 | 61202 | 56167132 |
Body dysmorphic disorder | 37.19 | 13.42 | 14 | 63719 | 314 | 56228020 |
Blood cholesterol increased | 36.87 | 13.42 | 18 | 63715 | 72561 | 56155773 |
Pleural effusion | 36.38 | 13.42 | 192 | 63541 | 85288 | 56143046 |
Osteoarthritis | 36.34 | 13.42 | 23 | 63710 | 80273 | 56148061 |
Disturbance in social behaviour | 36.25 | 13.42 | 29 | 63704 | 3012 | 56225322 |
Colitis | 36.25 | 13.42 | 117 | 63616 | 41694 | 56186640 |
Blood potassium decreased | 36.08 | 13.42 | 111 | 63622 | 38561 | 56189773 |
Asthenia | 35.82 | 13.42 | 566 | 63167 | 342407 | 55885927 |
Hypertension | 35.54 | 13.42 | 149 | 63584 | 244129 | 55984205 |
Depression | 34.94 | 13.42 | 97 | 63636 | 180020 | 56048314 |
Arthritis | 34.77 | 13.42 | 37 | 63696 | 99815 | 56128519 |
Nasal abscess | 34.70 | 13.42 | 11 | 63722 | 144 | 56228190 |
Osteonecrosis of jaw | 34.20 | 13.42 | 99 | 63634 | 33259 | 56195075 |
Death | 33.99 | 13.42 | 559 | 63174 | 340867 | 55887467 |
Impaired healing | 33.95 | 13.42 | 29 | 63704 | 86812 | 56141522 |
Taste disorder | 33.73 | 13.42 | 48 | 63685 | 9667 | 56218667 |
Crossmatch incompatible | 33.64 | 13.42 | 8 | 63725 | 31 | 56228303 |
Drug intolerance | 32.93 | 13.42 | 171 | 63562 | 264647 | 55963687 |
Hip arthroplasty | 32.70 | 13.42 | 3 | 63730 | 38620 | 56189714 |
Drug abuse | 32.52 | 13.42 | 18 | 63715 | 67592 | 56160742 |
Gastrointestinal fungal infection | 32.44 | 13.42 | 12 | 63721 | 256 | 56228078 |
Inappropriate schedule of product administration | 32.41 | 13.42 | 28 | 63705 | 83359 | 56144975 |
Fatigue | 32.18 | 13.42 | 1141 | 62592 | 787411 | 55440923 |
Blood pressure fluctuation | 31.97 | 13.42 | 4 | 63729 | 40356 | 56187978 |
Mantle cell lymphoma | 31.73 | 13.42 | 15 | 63718 | 601 | 56227733 |
Hypoaesthesia | 31.24 | 13.42 | 270 | 63463 | 141221 | 56087113 |
Hypokalaemia | 30.99 | 13.42 | 198 | 63535 | 94239 | 56134095 |
Loss of personal independence in daily activities | 30.81 | 13.42 | 28 | 63705 | 81341 | 56146993 |
Cerebellar haemangioma | 30.77 | 13.42 | 9 | 63724 | 88 | 56228246 |
Renal amyloidosis | 30.67 | 13.42 | 10 | 63723 | 144 | 56228190 |
Acute lymphocytic leukaemia | 30.24 | 13.42 | 25 | 63708 | 2719 | 56225615 |
Hypersensitivity myocarditis | 30.22 | 13.42 | 8 | 63725 | 52 | 56228282 |
Cardiac failure congestive | 30.08 | 13.42 | 186 | 63547 | 87534 | 56140800 |
Joint stiffness | 29.34 | 13.42 | 3 | 63730 | 35422 | 56192912 |
Target skin lesion | 29.33 | 13.42 | 9 | 63724 | 105 | 56228229 |
Acute kidney injury | 29.28 | 13.42 | 408 | 63325 | 240355 | 55987979 |
Blood stem cell harvest failure | 29.23 | 13.42 | 8 | 63725 | 60 | 56228274 |
Large intestine perforation | 29.06 | 13.42 | 40 | 63693 | 7811 | 56220523 |
Acute myeloid leukaemia | 28.69 | 13.42 | 61 | 63672 | 16911 | 56211423 |
Injury | 28.69 | 13.42 | 16 | 63717 | 59835 | 56168499 |
Clostridium bacteraemia | 28.45 | 13.42 | 10 | 63723 | 183 | 56228151 |
Suicidal ideation | 28.31 | 13.42 | 15 | 63718 | 57727 | 56170607 |
Neurotoxicity | 28.14 | 13.42 | 58 | 63675 | 15737 | 56212597 |
Guillain-Barre syndrome | 28.00 | 13.42 | 27 | 63706 | 3593 | 56224741 |
Blood pressure systolic increased | 28.00 | 13.42 | 6 | 63727 | 40830 | 56187504 |
Ill-defined disorder | 27.90 | 13.42 | 22 | 63711 | 68521 | 56159813 |
Renal impairment | 27.58 | 13.42 | 171 | 63562 | 80542 | 56147792 |
Refractory cytopenia with multilineage dysplasia | 27.02 | 13.42 | 9 | 63724 | 139 | 56228195 |
Spinal cord compression | 26.99 | 13.42 | 27 | 63706 | 3757 | 56224577 |
Bone lesion | 26.94 | 13.42 | 32 | 63701 | 5398 | 56222936 |
Blood lactate dehydrogenase increased | 26.88 | 13.42 | 67 | 63666 | 20608 | 56207726 |
Meningitis listeria | 26.75 | 13.42 | 13 | 63720 | 554 | 56227780 |
Sinus polyp | 26.45 | 13.42 | 11 | 63722 | 323 | 56228011 |
Pseudomonal sepsis | 26.38 | 13.42 | 21 | 63712 | 2165 | 56226169 |
Adenoviral haemorrhagic cystitis | 26.12 | 13.42 | 9 | 63724 | 155 | 56228179 |
Bronchiolitis | 26.09 | 13.42 | 22 | 63711 | 2460 | 56225874 |
Hyperproteinaemia | 26.02 | 13.42 | 8 | 63725 | 94 | 56228240 |
Wheezing | 25.90 | 13.42 | 28 | 63705 | 74998 | 56153336 |
Toxic skin eruption | 25.66 | 13.42 | 47 | 63686 | 11692 | 56216642 |
Heart rate increased | 25.63 | 13.42 | 34 | 63699 | 83239 | 56145095 |
Anaphylactic reaction | 25.21 | 13.42 | 18 | 63715 | 58977 | 56169357 |
Liver injury | 25.16 | 13.42 | 8 | 63725 | 41840 | 56186494 |
Stress | 25.14 | 13.42 | 18 | 63715 | 58892 | 56169442 |
Ileus | 24.76 | 13.42 | 51 | 63682 | 13831 | 56214503 |
Oncologic complication | 24.68 | 13.42 | 9 | 63724 | 184 | 56228150 |
Pregnancy | 24.47 | 13.42 | 4 | 63729 | 33029 | 56195305 |
Nasal congestion | 24.35 | 13.42 | 17 | 63716 | 56353 | 56171981 |
Graft versus host disease | 24.28 | 13.42 | 34 | 63699 | 6747 | 56221587 |
Transplant | 24.27 | 13.42 | 13 | 63720 | 681 | 56227653 |
Hypophosphataemia | 23.99 | 13.42 | 41 | 63692 | 9661 | 56218673 |
Malaise | 23.89 | 13.42 | 284 | 63449 | 367576 | 55860758 |
COVID-19 | 23.78 | 13.42 | 156 | 63577 | 74902 | 56153432 |
Sinusitis | 23.76 | 13.42 | 129 | 63604 | 197452 | 56030882 |
Joint ankylosis | 23.43 | 13.42 | 14 | 63719 | 905 | 56227429 |
Flushing | 23.28 | 13.42 | 27 | 63706 | 70073 | 56158261 |
Compression fracture | 22.90 | 13.42 | 31 | 63702 | 5958 | 56222376 |
Contusion | 22.84 | 13.42 | 72 | 63661 | 128358 | 56099976 |
Sleep disorder | 22.53 | 13.42 | 26 | 63707 | 67637 | 56160697 |
Pneumonia pneumococcal | 22.38 | 13.42 | 18 | 63715 | 1884 | 56226450 |
Salmonella sepsis | 22.31 | 13.42 | 9 | 63724 | 244 | 56228090 |
Intraductal proliferative breast lesion | 22.31 | 13.42 | 21 | 63712 | 2712 | 56225622 |
Gait disturbance | 22.28 | 13.42 | 102 | 63631 | 163219 | 56065115 |
N-terminal prohormone brain natriuretic peptide decreased | 22.27 | 13.42 | 5 | 63728 | 14 | 56228320 |
Thrombotic microangiopathy | 22.27 | 13.42 | 39 | 63694 | 9372 | 56218962 |
Palpitations | 22.18 | 13.42 | 50 | 63683 | 99622 | 56128712 |
Failure to thrive | 22.13 | 13.42 | 32 | 63701 | 6538 | 56221796 |
Neuralgia | 22.09 | 13.42 | 68 | 63665 | 23627 | 56204707 |
Injection site swelling | 21.84 | 13.42 | 11 | 63722 | 43567 | 56184767 |
Type 2 diabetes mellitus | 21.79 | 13.42 | 13 | 63720 | 46849 | 56181485 |
Hypothyroidism | 21.76 | 13.42 | 8 | 63725 | 38188 | 56190146 |
Bacteraemia | 21.75 | 13.42 | 52 | 63681 | 15579 | 56212755 |
Peritonitis viral | 21.58 | 13.42 | 6 | 63727 | 48 | 56228286 |
Varicella zoster virus infection | 21.37 | 13.42 | 20 | 63713 | 2564 | 56225770 |
Product quality issue | 21.08 | 13.42 | 5 | 63728 | 31731 | 56196603 |
Weight increased | 20.99 | 13.42 | 163 | 63570 | 229540 | 55998794 |
Enterococcal sepsis | 20.99 | 13.42 | 15 | 63718 | 1315 | 56227019 |
Mucosal inflammation | 20.92 | 13.42 | 100 | 63633 | 42710 | 56185624 |
Blepharitis | 20.81 | 13.42 | 19 | 63714 | 2361 | 56225973 |
Myalgia | 20.78 | 13.42 | 78 | 63655 | 131947 | 56096387 |
Infusion related reaction | 20.65 | 13.42 | 145 | 63588 | 208786 | 56019548 |
Rash | 20.65 | 13.42 | 716 | 63017 | 492331 | 55736003 |
Urosepsis | 20.51 | 13.42 | 53 | 63680 | 16663 | 56211671 |
Acute respiratory distress syndrome | 20.51 | 13.42 | 63 | 63670 | 21863 | 56206471 |
Human chorionic gonadotropin increased | 20.43 | 13.42 | 15 | 63718 | 1371 | 56226963 |
Sedation | 20.36 | 13.42 | 7 | 63726 | 34847 | 56193487 |
Hypotension | 20.23 | 13.42 | 397 | 63336 | 250111 | 55978223 |
Hypoalbuminaemia | 20.17 | 13.42 | 40 | 63693 | 10559 | 56217775 |
Serotonin syndrome | 20.09 | 13.42 | 3 | 63730 | 26487 | 56201847 |
Toxicity to various agents | 19.89 | 13.42 | 361 | 63372 | 224203 | 56004131 |
Cardiotoxicity | 19.81 | 13.42 | 33 | 63700 | 7617 | 56220717 |
Osteoporosis | 19.60 | 13.42 | 18 | 63715 | 52034 | 56176300 |
Pulmonary embolism | 19.40 | 13.42 | 196 | 63537 | 106928 | 56121406 |
Blood creatine phosphokinase increased | 19.38 | 13.42 | 4 | 63729 | 27948 | 56200386 |
5q minus syndrome | 19.30 | 13.42 | 8 | 63725 | 233 | 56228101 |
Rhinovirus infection | 19.27 | 13.42 | 23 | 63710 | 3899 | 56224435 |
Adverse drug reaction | 19.21 | 13.42 | 133 | 63600 | 64999 | 56163335 |
Spinal fracture | 19.06 | 13.42 | 51 | 63682 | 16373 | 56211961 |
Tooth disorder | 19.06 | 13.42 | 68 | 63665 | 25485 | 56202849 |
Mucosal erosion | 18.90 | 13.42 | 14 | 63719 | 1297 | 56227037 |
Injection site bruising | 18.89 | 13.42 | 10 | 63723 | 38511 | 56189823 |
VIth nerve paresis | 18.89 | 13.42 | 6 | 63727 | 79 | 56228255 |
Seasonal allergy | 18.73 | 13.42 | 52 | 63681 | 17056 | 56211278 |
Back pain | 18.53 | 13.42 | 374 | 63359 | 236796 | 55991538 |
Pulmonary oedema | 18.51 | 13.42 | 110 | 63623 | 51033 | 56177301 |
Acute myopia | 18.49 | 13.42 | 6 | 63727 | 85 | 56228249 |
Plasma cells decreased | 18.44 | 13.42 | 5 | 63728 | 36 | 56228298 |
Pain in extremity | 18.39 | 13.42 | 232 | 63501 | 297199 | 55931135 |
Somnolence | 18.39 | 13.42 | 109 | 63624 | 163304 | 56065030 |
Disease recurrence | 18.23 | 13.42 | 64 | 63669 | 23796 | 56204538 |
Asthma | 18.16 | 13.42 | 66 | 63667 | 112704 | 56115630 |
Full blood count increased | 18.10 | 13.42 | 12 | 63721 | 931 | 56227403 |
Light chain analysis | 17.87 | 13.42 | 4 | 63729 | 11 | 56228323 |
Clostridium difficile colitis | 17.68 | 13.42 | 54 | 63679 | 18684 | 56209650 |
Fungal oesophagitis | 17.60 | 13.42 | 10 | 63723 | 588 | 56227746 |
Sleep apnoea syndrome | 17.52 | 13.42 | 4 | 63729 | 26057 | 56202277 |
Cough | 17.51 | 13.42 | 199 | 63534 | 259762 | 55968572 |
Monoclonal immunoglobulin increased | 17.48 | 13.42 | 6 | 63727 | 102 | 56228232 |
Paraesthesia | 17.42 | 13.42 | 225 | 63508 | 130289 | 56098045 |
Lymphopenia | 17.40 | 13.42 | 50 | 63683 | 16724 | 56211610 |
Foot deformity | 17.39 | 13.42 | 3 | 63730 | 23822 | 56204512 |
Diarrhoea haemorrhagic | 17.33 | 13.42 | 32 | 63701 | 8011 | 56220323 |
Underdose | 17.32 | 13.42 | 3 | 63730 | 23754 | 56204580 |
Meningitis cryptococcal | 17.27 | 13.42 | 13 | 63720 | 1234 | 56227100 |
Respiratory failure | 17.25 | 13.42 | 174 | 63559 | 94888 | 56133446 |
Drug reaction with eosinophilia and systemic symptoms | 17.20 | 13.42 | 74 | 63659 | 30230 | 56198104 |
Pneumonia influenzal | 17.20 | 13.42 | 14 | 63719 | 1490 | 56226844 |
Hyperintensity in brain deep nuclei | 17.14 | 13.42 | 4 | 63729 | 14 | 56228320 |
Therapy interrupted | 17.09 | 13.42 | 4 | 63729 | 25621 | 56202713 |
Hypogammaglobulinaemia | 17.01 | 13.42 | 28 | 63705 | 6398 | 56221936 |
Nocardiosis | 16.92 | 13.42 | 15 | 63718 | 1793 | 56226541 |
Hypoglossal nerve paresis | 16.91 | 13.42 | 6 | 63727 | 113 | 56228221 |
Inflammation | 16.75 | 13.42 | 33 | 63700 | 69038 | 56159296 |
Infection reactivation | 16.70 | 13.42 | 12 | 63721 | 1061 | 56227273 |
Clostridium difficile infection | 16.68 | 13.42 | 68 | 63665 | 27130 | 56201204 |
Osteonecrosis | 16.65 | 13.42 | 61 | 63672 | 23154 | 56205180 |
Incorrect dose administered | 16.64 | 13.42 | 21 | 63712 | 52526 | 56175808 |
Myeloma cast nephropathy | 16.62 | 13.42 | 6 | 63727 | 119 | 56228215 |
Pseudomyopia | 16.56 | 13.42 | 5 | 63728 | 55 | 56228279 |
Spinal compression fracture | 16.49 | 13.42 | 42 | 63691 | 13092 | 56215242 |
Duodenal stenosis | 16.35 | 13.42 | 9 | 63724 | 498 | 56227836 |
Cardiac failure acute | 16.30 | 13.42 | 33 | 63700 | 8840 | 56219494 |
Superficial spreading melanoma stage unspecified | 16.17 | 13.42 | 6 | 63727 | 129 | 56228205 |
Human herpesvirus 8 infection | 16.16 | 13.42 | 7 | 63726 | 228 | 56228106 |
Lower respiratory tract infection | 16.07 | 13.42 | 71 | 63662 | 114723 | 56113611 |
Autoimmune retinopathy | 15.83 | 13.42 | 4 | 63729 | 21 | 56228313 |
Coma | 15.80 | 13.42 | 27 | 63706 | 59628 | 56168706 |
Injection site haemorrhage | 15.76 | 13.42 | 3 | 63730 | 22198 | 56206136 |
Chronic graft versus host disease in skin | 15.76 | 13.42 | 10 | 63723 | 720 | 56227614 |
Sensory level abnormal | 15.76 | 13.42 | 6 | 63727 | 139 | 56228195 |
Hyperamylasaemia | 15.72 | 13.42 | 8 | 63725 | 377 | 56227957 |
Dysarthria | 15.71 | 13.42 | 13 | 63720 | 39537 | 56188797 |
Infection in an immunocompromised host | 15.66 | 13.42 | 9 | 63724 | 541 | 56227793 |
Staphylococcal bacteraemia | 15.59 | 13.42 | 24 | 63709 | 5185 | 56223149 |
Aggression | 15.57 | 13.42 | 3 | 63730 | 22003 | 56206331 |
Performance status decreased | 15.53 | 13.42 | 19 | 63714 | 3304 | 56225030 |
Drug withdrawal syndrome | 15.44 | 13.42 | 5 | 63728 | 25852 | 56202482 |
Rhabdomyolysis | 15.38 | 13.42 | 14 | 63719 | 40644 | 56187690 |
Myelosuppression | 15.26 | 13.42 | 49 | 63684 | 17406 | 56210928 |
Joint injury | 15.25 | 13.42 | 5 | 63728 | 25649 | 56202685 |
Clavicle fracture | 15.20 | 13.42 | 18 | 63715 | 3027 | 56225307 |
Blood immunoglobulin A increased | 15.02 | 13.42 | 8 | 63725 | 414 | 56227920 |
Pulmonary alveolar haemorrhage | 14.70 | 13.42 | 21 | 63712 | 4243 | 56224091 |
Cryptococcosis | 14.70 | 13.42 | 11 | 63722 | 1035 | 56227299 |
Rash pruritic | 14.69 | 13.42 | 106 | 63627 | 52488 | 56175846 |
Respiratory tract infection | 14.64 | 13.42 | 80 | 63653 | 35991 | 56192343 |
JC virus CSF test positive | 14.61 | 13.42 | 4 | 63729 | 30 | 56228304 |
Paraproteinaemia | 14.53 | 13.42 | 6 | 63727 | 173 | 56228161 |
Urticaria | 14.48 | 13.42 | 100 | 63633 | 144576 | 56083758 |
Haemorrhoidal haemorrhage | 14.33 | 13.42 | 20 | 63713 | 3956 | 56224378 |
Hepatitis B | 14.23 | 13.42 | 19 | 63714 | 3605 | 56224729 |
Nasopharyngitis | 14.16 | 13.42 | 171 | 63562 | 220788 | 56007546 |
Atelectasis | 14.07 | 13.42 | 51 | 63682 | 19257 | 56209077 |
Blood magnesium decreased | 13.91 | 13.42 | 37 | 63696 | 11837 | 56216497 |
Skin exfoliation | 13.76 | 13.42 | 80 | 63653 | 36820 | 56191514 |
Decreased appetite | 13.72 | 13.42 | 335 | 63398 | 218896 | 56009438 |
Pneumonia cytomegaloviral | 13.69 | 13.42 | 14 | 63719 | 2000 | 56226334 |
Therapy cessation | 13.49 | 13.42 | 7 | 63726 | 27257 | 56201077 |
Precursor B-lymphoblastic lymphoma | 13.47 | 13.42 | 3 | 63730 | 8 | 56228326 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Plasma cell myeloma | 6273.25 | 13.01 | 2924 | 72306 | 53607 | 31568507 |
Neuropathy peripheral | 2435.35 | 13.01 | 1752 | 73478 | 73897 | 31548217 |
Plasma cell myeloma recurrent | 582.21 | 13.01 | 250 | 74980 | 3674 | 31618440 |
Polyneuropathy | 518.91 | 13.01 | 345 | 74885 | 12677 | 31609437 |
Thrombocytopenia | 447.22 | 13.01 | 1021 | 74209 | 141726 | 31480388 |
Platelet count decreased | 390.99 | 13.01 | 830 | 74400 | 109605 | 31512509 |
Plasmacytoma | 330.19 | 13.01 | 161 | 75069 | 3216 | 31618898 |
Disease progression | 306.27 | 13.01 | 668 | 74562 | 89796 | 31532318 |
Drug interaction | 275.85 | 13.01 | 77 | 75153 | 208466 | 31413648 |
Pneumonia | 272.86 | 13.01 | 1535 | 73695 | 333777 | 31288337 |
Unevaluable event | 223.35 | 13.01 | 317 | 74913 | 30258 | 31591856 |
Completed suicide | 201.66 | 13.01 | 3 | 75227 | 91511 | 31530603 |
Drug abuse | 192.84 | 13.01 | 3 | 75227 | 87755 | 31534359 |
Plasma cell leukaemia | 179.60 | 13.01 | 72 | 75158 | 879 | 31621235 |
Tumour lysis syndrome | 165.02 | 13.01 | 193 | 75037 | 15192 | 31606922 |
Orthostatic hypotension | 161.46 | 13.01 | 240 | 74990 | 23879 | 31598235 |
Herpes zoster | 138.65 | 13.01 | 262 | 74968 | 31731 | 31590383 |
Plasma cell myeloma refractory | 133.79 | 13.01 | 36 | 75194 | 101 | 31622013 |
White blood cell count decreased | 128.96 | 13.01 | 478 | 74752 | 86920 | 31535194 |
Amyloidosis | 123.70 | 13.01 | 73 | 75157 | 2163 | 31619951 |
Diarrhoea | 123.05 | 13.01 | 1326 | 73904 | 351083 | 31271031 |
Overdose | 121.98 | 13.01 | 26 | 75204 | 84638 | 31537476 |
Constipation | 120.92 | 13.01 | 598 | 74632 | 123393 | 31498721 |
Peripheral sensory neuropathy | 118.36 | 13.01 | 107 | 75123 | 6208 | 31615906 |
Autonomic neuropathy | 111.26 | 13.01 | 50 | 75180 | 823 | 31621291 |
Fatigue | 109.48 | 13.01 | 1245 | 73985 | 333961 | 31288153 |
Product use issue | 104.25 | 13.01 | 334 | 74896 | 56425 | 31565689 |
Deep vein thrombosis | 104.02 | 13.01 | 349 | 74881 | 60387 | 31561727 |
Primary amyloidosis | 96.06 | 13.01 | 29 | 75201 | 137 | 31621977 |
Neutropenia | 93.25 | 13.01 | 611 | 74619 | 139753 | 31482361 |
Headache | 91.89 | 13.01 | 186 | 75044 | 183466 | 31438648 |
Hypercalcaemia | 91.80 | 13.01 | 138 | 75092 | 13862 | 31608252 |
Rhabdomyolysis | 90.60 | 13.01 | 20 | 75210 | 63561 | 31558553 |
Light chain analysis increased | 86.54 | 13.01 | 47 | 75183 | 1183 | 31620931 |
Pancytopenia | 84.94 | 13.01 | 421 | 74809 | 86895 | 31535219 |
Psoriasis | 84.62 | 13.01 | 7 | 75223 | 46712 | 31575402 |
Rash | 83.42 | 13.01 | 786 | 74444 | 200700 | 31421414 |
Ileus paralytic | 82.94 | 13.01 | 82 | 75148 | 5326 | 31616788 |
Osteonecrosis of jaw | 79.20 | 13.01 | 144 | 75086 | 16927 | 31605187 |
Full blood count decreased | 78.62 | 13.01 | 141 | 75089 | 16399 | 31605715 |
Thrombosis | 74.25 | 13.01 | 256 | 74974 | 44895 | 31577219 |
Therapy partial responder | 73.16 | 13.01 | 84 | 75146 | 6478 | 31615636 |
Product use in unapproved indication | 72.82 | 13.01 | 443 | 74787 | 98728 | 31523386 |
Myelodysplastic syndrome | 71.71 | 13.01 | 148 | 75082 | 19103 | 31603011 |
Off label use | 70.69 | 13.01 | 1186 | 74044 | 346088 | 31276026 |
Cystitis haemorrhagic | 69.86 | 13.01 | 74 | 75156 | 5215 | 31616899 |
Blood creatine phosphokinase increased | 69.04 | 13.01 | 9 | 75221 | 41965 | 31580149 |
Arthralgia | 67.77 | 13.01 | 163 | 75067 | 151261 | 31470853 |
Cytopenia | 67.21 | 13.01 | 105 | 75125 | 10905 | 31611209 |
Inappropriate schedule of product administration | 66.58 | 13.01 | 19 | 75211 | 50804 | 31571310 |
Hypertension | 62.94 | 13.01 | 131 | 75099 | 127969 | 31494145 |
Depression | 62.56 | 13.01 | 74 | 75156 | 90741 | 31531373 |
B precursor type acute leukaemia | 61.01 | 13.01 | 23 | 75207 | 235 | 31621879 |
Condition aggravated | 59.03 | 13.01 | 196 | 75034 | 163813 | 31458301 |
Abdominal pain | 56.32 | 13.01 | 169 | 75061 | 145783 | 31476331 |
Chalazion | 55.64 | 13.01 | 18 | 75212 | 111 | 31622003 |
Adverse drug reaction | 54.39 | 13.01 | 157 | 75073 | 25044 | 31597070 |
Spinal compression fracture | 52.65 | 13.01 | 71 | 75159 | 6451 | 31615663 |
Blood pressure increased | 52.62 | 13.01 | 67 | 75163 | 79566 | 31542548 |
Aggression | 52.57 | 13.01 | 12 | 75218 | 37279 | 31584835 |
Seizure | 52.46 | 13.01 | 98 | 75132 | 99670 | 31522444 |
Neuralgia | 52.40 | 13.01 | 98 | 75132 | 11768 | 31610346 |
Anxiety | 51.88 | 13.01 | 85 | 75145 | 90948 | 31531166 |
Drug hypersensitivity | 51.24 | 13.01 | 58 | 75172 | 72541 | 31549573 |
Infection | 50.92 | 13.01 | 351 | 74879 | 81580 | 31540534 |
Hypoaesthesia | 50.84 | 13.01 | 265 | 74965 | 55757 | 31566357 |
Cardiac amyloidosis | 50.61 | 13.01 | 31 | 75199 | 984 | 31621130 |
Pyrexia | 50.59 | 13.01 | 1006 | 74224 | 302834 | 31319280 |
Protein total increased | 49.13 | 13.01 | 41 | 75189 | 2134 | 31619980 |
Suicidal ideation | 48.82 | 13.01 | 13 | 75217 | 36393 | 31585721 |
Atrial fibrillation | 47.52 | 13.01 | 445 | 74785 | 113338 | 31508776 |
Sepsis | 45.18 | 13.01 | 555 | 74675 | 151374 | 31470740 |
Spinal cord compression | 44.91 | 13.01 | 50 | 75180 | 3727 | 31618387 |
Wrong technique in product usage process | 44.53 | 13.01 | 12 | 75218 | 33331 | 31588783 |
Laboratory test abnormal | 44.31 | 13.01 | 121 | 75109 | 18693 | 31603421 |
Asthma | 44.11 | 13.01 | 23 | 75207 | 42588 | 31579526 |
Hypoglycaemia | 43.83 | 13.01 | 34 | 75196 | 50912 | 31571202 |
Compression fracture | 43.22 | 13.01 | 43 | 75187 | 2814 | 31619300 |
Stem cell transplant | 42.97 | 13.01 | 37 | 75193 | 2011 | 31620103 |
Therapy non-responder | 40.97 | 13.01 | 174 | 75056 | 33637 | 31588477 |
BK virus infection | 40.42 | 13.01 | 55 | 75175 | 5040 | 31617074 |
Peripheral sensorimotor neuropathy | 40.25 | 13.01 | 31 | 75199 | 1437 | 31620677 |
Haematochezia | 40.20 | 13.01 | 23 | 75207 | 40441 | 31581673 |
Bradycardia | 40.17 | 13.01 | 64 | 75166 | 69263 | 31552851 |
Ageusia | 39.88 | 13.01 | 76 | 75154 | 9255 | 31612859 |
Paraesthesia | 39.54 | 13.01 | 248 | 74982 | 55823 | 31566291 |
Stress | 39.48 | 13.01 | 6 | 75224 | 24935 | 31597179 |
Hyperviscosity syndrome | 39.21 | 13.01 | 16 | 75214 | 205 | 31621909 |
Septic shock | 38.50 | 13.01 | 279 | 74951 | 65879 | 31556235 |
Metapneumovirus infection | 38.30 | 13.01 | 22 | 75208 | 619 | 31621495 |
Guillain-Barre syndrome | 36.80 | 13.01 | 54 | 75176 | 5306 | 31616808 |
Rash pruritic | 36.13 | 13.01 | 132 | 75098 | 23806 | 31598308 |
Monoclonal immunoglobulin present | 35.39 | 13.01 | 24 | 75206 | 910 | 31621204 |
Pathological fracture | 35.35 | 13.01 | 46 | 75184 | 4036 | 31618078 |
Neutrophil count decreased | 35.11 | 13.01 | 209 | 75021 | 46185 | 31575929 |
Hypogammaglobulinaemia | 34.74 | 13.01 | 59 | 75171 | 6568 | 31615546 |
Agitation | 34.31 | 13.01 | 47 | 75183 | 54122 | 31567992 |
Oroantral fistula | 33.20 | 13.01 | 14 | 75216 | 196 | 31621918 |
Intentional product misuse | 33.06 | 13.01 | 25 | 75205 | 37926 | 31584188 |
Hallucination | 32.82 | 13.01 | 37 | 75193 | 46373 | 31575741 |
Bone pain | 32.03 | 13.01 | 110 | 75120 | 19241 | 31602873 |
Flushing | 31.57 | 13.01 | 16 | 75214 | 30112 | 31592002 |
Bone disorder | 31.56 | 13.01 | 53 | 75177 | 5846 | 31616268 |
Asthenia | 31.45 | 13.01 | 726 | 74504 | 224029 | 31398085 |
Hyperkalaemia | 31.41 | 13.01 | 66 | 75164 | 64285 | 31557829 |
Malaise | 31.23 | 13.01 | 253 | 74977 | 168258 | 31453856 |
Progressive multifocal leukoencephalopathy | 31.03 | 13.01 | 68 | 75162 | 9145 | 31612969 |
Squamous cell carcinoma of skin | 30.82 | 13.01 | 72 | 75158 | 10102 | 31612012 |
Angioedema | 30.78 | 13.01 | 21 | 75209 | 33597 | 31588517 |
Contraindicated product administered | 30.74 | 13.01 | 5 | 75225 | 19767 | 31602347 |
Hiccups | 30.66 | 13.01 | 68 | 75162 | 9219 | 31612895 |
H1N1 influenza | 30.65 | 13.01 | 22 | 75208 | 915 | 31621199 |
Electrocardiogram QT prolonged | 30.63 | 13.01 | 27 | 75203 | 37960 | 31584154 |
Colitis ulcerative | 30.40 | 13.01 | 4 | 75226 | 18525 | 31603589 |
Erythema | 30.33 | 13.01 | 94 | 75136 | 80311 | 31541803 |
Dehydration | 30.30 | 13.01 | 423 | 74807 | 118688 | 31503426 |
Adenocarcinoma of colon | 30.04 | 13.01 | 38 | 75192 | 3242 | 31618872 |
Hordeolum | 29.45 | 13.01 | 21 | 75209 | 864 | 31621250 |
Renal failure | 29.39 | 13.01 | 433 | 74797 | 122897 | 31499217 |
Drug-induced liver injury | 28.58 | 13.01 | 11 | 75219 | 24352 | 31597762 |
Osteonecrosis | 28.52 | 13.01 | 85 | 75145 | 13799 | 31608315 |
Ileus | 28.48 | 13.01 | 90 | 75140 | 15079 | 31607035 |
Parainfluenzae virus infection | 28.40 | 13.01 | 32 | 75198 | 2417 | 31619697 |
Pulmonary embolism | 28.13 | 13.01 | 307 | 74923 | 81339 | 31540775 |
Incorrect dose administered | 28.12 | 13.01 | 26 | 75204 | 35726 | 31586388 |
Somnolence | 27.97 | 13.01 | 131 | 75099 | 99314 | 31522800 |
Myocardial infarction | 27.66 | 13.01 | 157 | 75073 | 113297 | 31508817 |
Peripheral motor neuropathy | 27.65 | 13.01 | 27 | 75203 | 1727 | 31620387 |
Bacterial infection | 27.17 | 13.01 | 83 | 75147 | 13656 | 31608458 |
Bone marrow failure | 27.15 | 13.01 | 135 | 75095 | 27873 | 31594241 |
Hyperhidrosis | 26.70 | 13.01 | 77 | 75153 | 67316 | 31554798 |
Lactic acidosis | 26.60 | 13.01 | 22 | 75208 | 31915 | 31590199 |
Metabolic acidosis | 26.44 | 13.01 | 33 | 75197 | 39544 | 31582570 |
Osteolysis | 26.42 | 13.01 | 30 | 75200 | 2285 | 31619829 |
Injection site pain | 26.29 | 13.01 | 26 | 75204 | 34608 | 31587506 |
Blood stem cell harvest failure | 26.18 | 13.01 | 7 | 75223 | 19 | 31622095 |
Respirovirus test positive | 26.03 | 13.01 | 9 | 75221 | 70 | 31622044 |
Gastrointestinal amyloidosis | 25.92 | 13.01 | 7 | 75223 | 20 | 31622094 |
Renal amyloidosis | 25.92 | 13.01 | 9 | 75221 | 71 | 31622043 |
Visceral leishmaniasis | 25.65 | 13.01 | 16 | 75214 | 525 | 31621589 |
Drug level increased | 25.60 | 13.01 | 8 | 75222 | 20178 | 31601936 |
Bacteraemia | 25.57 | 13.01 | 96 | 75134 | 17538 | 31604576 |
Blood pressure fluctuation | 25.48 | 13.01 | 11 | 75219 | 22725 | 31599389 |
Mobility decreased | 25.36 | 13.01 | 17 | 75213 | 27452 | 31594662 |
Tooth deposit | 25.28 | 13.01 | 9 | 75221 | 77 | 31622037 |
Anaphylactic reaction | 25.06 | 13.01 | 20 | 75210 | 29533 | 31592581 |
VIth nerve paralysis | 25.00 | 13.01 | 18 | 75212 | 752 | 31621362 |
Diverticular perforation | 24.82 | 13.01 | 34 | 75196 | 3135 | 31618979 |
Meningitis pneumococcal | 24.10 | 13.01 | 11 | 75219 | 188 | 31621926 |
Performance status decreased | 23.69 | 13.01 | 37 | 75193 | 3841 | 31618273 |
Acute lymphocytic leukaemia | 23.61 | 13.01 | 35 | 75195 | 3471 | 31618643 |
Pallor | 23.36 | 13.01 | 12 | 75218 | 22412 | 31599702 |
Bone lesion | 23.33 | 13.01 | 31 | 75199 | 2776 | 31619338 |
Musculoskeletal stiffness | 23.14 | 13.01 | 39 | 75191 | 41286 | 31580828 |
Abnormal behaviour | 23.02 | 13.01 | 14 | 75216 | 23814 | 31598300 |
Wheezing | 23.01 | 13.01 | 31 | 75199 | 35955 | 31586159 |
Phrenic nerve paralysis | 22.89 | 13.01 | 9 | 75221 | 104 | 31622010 |
Autologous haematopoietic stem cell transplant | 22.79 | 13.01 | 6 | 75224 | 15 | 31622099 |
Spinal fracture | 22.25 | 13.01 | 50 | 75180 | 6838 | 31615276 |
Dysarthria | 22.12 | 13.01 | 26 | 75204 | 31991 | 31590123 |
Hepatitis B reactivation | 22.10 | 13.01 | 34 | 75196 | 3484 | 31618630 |
Demyelinating polyneuropathy | 21.99 | 13.01 | 20 | 75210 | 1169 | 31620945 |
Cytomegalovirus infection | 21.80 | 13.01 | 116 | 75114 | 24591 | 31597523 |
Palmar-plantar erythrodysaesthesia syndrome | 21.78 | 13.01 | 5 | 75225 | 15478 | 31606636 |
Tachycardia | 21.65 | 13.01 | 100 | 75130 | 76107 | 31546007 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 21.62 | 13.01 | 16 | 75214 | 698 | 31621416 |
JC virus infection | 21.35 | 13.01 | 25 | 75205 | 1969 | 31620145 |
Product prescribing error | 21.23 | 13.01 | 10 | 75220 | 19632 | 31602482 |
Anaphylactic shock | 21.07 | 13.01 | 4 | 75226 | 14141 | 31607973 |
Coronary artery disease | 21.06 | 13.01 | 49 | 75181 | 46038 | 31576076 |
Myalgia | 21.00 | 13.01 | 103 | 75127 | 77155 | 31544959 |
Haemoglobin decreased | 20.67 | 13.01 | 379 | 74851 | 112296 | 31509818 |
Disturbance in attention | 20.58 | 13.01 | 14 | 75216 | 22436 | 31599678 |
Brief psychotic disorder with marked stressors | 20.40 | 13.01 | 10 | 75220 | 202 | 31621912 |
Accidental overdose | 20.37 | 13.01 | 9 | 75221 | 18341 | 31603773 |
Blood immunoglobulin M increased | 20.09 | 13.01 | 10 | 75220 | 209 | 31621905 |
Ascites | 20.06 | 13.01 | 42 | 75188 | 40971 | 31581143 |
Gastric ulcer | 20.05 | 13.01 | 5 | 75225 | 14629 | 31607485 |
Cerebrovascular accident | 19.90 | 13.01 | 109 | 75121 | 79375 | 31542739 |
Respiratory depression | 19.80 | 13.01 | 5 | 75225 | 14505 | 31607609 |
Neurogenic bladder | 19.79 | 13.01 | 22 | 75208 | 1637 | 31620477 |
Conjunctival irritation | 19.71 | 13.01 | 8 | 75222 | 101 | 31622013 |
Acute febrile neutrophilic dermatosis | 19.54 | 13.01 | 19 | 75211 | 1209 | 31620905 |
Acute myeloid leukaemia | 19.53 | 13.01 | 92 | 75138 | 18580 | 31603534 |
Loss of personal independence in daily activities | 19.51 | 13.01 | 23 | 75207 | 28265 | 31593849 |
Emotional distress | 19.48 | 13.01 | 5 | 75225 | 14351 | 31607763 |
Rectal adenocarcinoma | 19.47 | 13.01 | 16 | 75214 | 815 | 31621299 |
Blood pressure systolic increased | 19.43 | 13.01 | 11 | 75219 | 19459 | 31602655 |
Febrile neutropenia | 19.35 | 13.01 | 401 | 74829 | 121448 | 31500666 |
Synovitis | 19.34 | 13.01 | 3 | 75227 | 12280 | 31609834 |
Basal cell carcinoma | 19.33 | 13.01 | 90 | 75140 | 18089 | 31604025 |
Depressed level of consciousness | 19.33 | 13.01 | 39 | 75191 | 38562 | 31583552 |
Monoclonal gammopathy | 19.33 | 13.01 | 11 | 75219 | 304 | 31621810 |
Blood immunoglobulin A increased | 19.23 | 13.01 | 11 | 75219 | 307 | 31621807 |
Infusion related reaction | 19.06 | 13.01 | 186 | 75044 | 47869 | 31574245 |
Polyomavirus-associated nephropathy | 19.01 | 13.01 | 32 | 75198 | 3536 | 31618578 |
End stage renal disease | 18.94 | 13.01 | 52 | 75178 | 8057 | 31614057 |
Rib fracture | 18.90 | 13.01 | 72 | 75158 | 13244 | 31608870 |
Hallucination, visual | 18.75 | 13.01 | 7 | 75223 | 15787 | 31606327 |
Cardiac arrest | 18.72 | 13.01 | 129 | 75101 | 88933 | 31533181 |
Respiratory arrest | 18.49 | 13.01 | 21 | 75209 | 26236 | 31595878 |
Jaundice | 18.46 | 13.01 | 27 | 75203 | 30260 | 31591854 |
Enterococcal infection | 18.45 | 13.01 | 54 | 75176 | 8677 | 31613437 |
Blood immunoglobulin G increased | 18.40 | 13.01 | 16 | 75214 | 881 | 31621233 |
Clostridium difficile colitis | 18.33 | 13.01 | 74 | 75156 | 13982 | 31608132 |
Haematuria | 18.28 | 13.01 | 53 | 75177 | 46261 | 31575853 |
Neuromyotonia | 18.28 | 13.01 | 6 | 75224 | 39 | 31622075 |
Anaemia | 18.20 | 13.01 | 648 | 74582 | 212874 | 31409240 |
Blood calcium increased | 18.11 | 13.01 | 30 | 75200 | 3272 | 31618842 |
Obstructive airways disorder | 17.99 | 13.01 | 4 | 75226 | 12660 | 31609454 |
Dyskinesia | 17.92 | 13.01 | 14 | 75216 | 20896 | 31601218 |
Sopor | 17.78 | 13.01 | 3 | 75227 | 11549 | 31610565 |
Heart rate increased | 17.76 | 13.01 | 45 | 75185 | 41065 | 31581049 |
Accidental exposure to product | 17.66 | 13.01 | 3 | 75227 | 11492 | 31610622 |
Depressed mood | 17.44 | 13.01 | 10 | 75220 | 17565 | 31604549 |
Medication error | 17.39 | 13.01 | 17 | 75213 | 22755 | 31599359 |
Vomiting | 17.37 | 13.01 | 402 | 74828 | 223571 | 31398543 |
Alanine aminotransferase increased | 17.28 | 13.01 | 105 | 75125 | 74551 | 31547563 |
Respiratory tract infection | 17.27 | 13.01 | 85 | 75145 | 17476 | 31604638 |
Melaena | 17.21 | 13.01 | 32 | 75198 | 32622 | 31589492 |
Gastrooesophageal reflux disease | 17.15 | 13.01 | 34 | 75196 | 33837 | 31588277 |
Hyperlipidaemia | 17.08 | 13.01 | 5 | 75225 | 13155 | 31608959 |
Coma | 17.05 | 13.01 | 46 | 75184 | 41104 | 31581010 |
Nephrolithiasis | 17.03 | 13.01 | 24 | 75206 | 27315 | 31594799 |
Blepharitis | 16.86 | 13.01 | 17 | 75213 | 1130 | 31620984 |
Type 2 diabetes mellitus | 16.81 | 13.01 | 7 | 75223 | 14777 | 31607337 |
Cytomegalovirus infection reactivation | 16.79 | 13.01 | 32 | 75198 | 3897 | 31618217 |
Pleuritic pain | 16.65 | 13.01 | 28 | 75202 | 3092 | 31619022 |
Aphasia | 16.27 | 13.01 | 14 | 75216 | 19917 | 31602197 |
Diabetic ketoacidosis | 16.24 | 13.01 | 10 | 75220 | 16895 | 31605219 |
Product quality issue | 16.22 | 13.01 | 9 | 75221 | 16102 | 31606012 |
Extrapyramidal disorder | 16.18 | 13.01 | 4 | 75226 | 11774 | 31610340 |
Laryngeal cancer metastatic | 16.12 | 13.01 | 6 | 75224 | 59 | 31622055 |
Haemorrhagic fever | 16.01 | 13.01 | 5 | 75225 | 27 | 31622087 |
Pain | 15.97 | 13.01 | 330 | 74900 | 186429 | 31435685 |
Hypersensitivity | 15.92 | 13.01 | 73 | 75157 | 55670 | 31566444 |
Injury | 15.90 | 13.01 | 14 | 75216 | 19695 | 31602419 |
Full blood count increased | 15.86 | 13.01 | 14 | 75216 | 787 | 31621327 |
Autonomic nervous system imbalance | 15.72 | 13.01 | 24 | 75206 | 2443 | 31619671 |
Fat tissue increased | 15.71 | 13.01 | 10 | 75220 | 340 | 31621774 |
Spinal column injury | 15.64 | 13.01 | 12 | 75218 | 553 | 31621561 |
Cholestasis | 15.63 | 13.01 | 22 | 75208 | 25053 | 31597061 |
Blood lactate dehydrogenase increased | 15.62 | 13.01 | 92 | 75138 | 20247 | 31601867 |
Hypocalcaemic seizure | 15.57 | 13.01 | 5 | 75225 | 30 | 31622084 |
Genital erythema | 15.50 | 13.01 | 8 | 75222 | 181 | 31621933 |
Escherichia sepsis | 15.47 | 13.01 | 32 | 75198 | 4135 | 31617979 |
Glycosylated haemoglobin increased | 15.36 | 13.01 | 3 | 75227 | 10397 | 31611717 |
Eosinophilic pneumonia chronic | 15.33 | 13.01 | 9 | 75221 | 264 | 31621850 |
Bacterial parotitis | 15.30 | 13.01 | 5 | 75225 | 32 | 31622082 |
Neutropenic sepsis | 15.22 | 13.01 | 64 | 75166 | 12315 | 31609799 |
Oesophageal adenocarcinoma | 15.21 | 13.01 | 14 | 75216 | 831 | 31621283 |
Chest discomfort | 15.10 | 13.01 | 63 | 75167 | 49306 | 31572808 |
Hepatic steatosis | 15.06 | 13.01 | 10 | 75220 | 16229 | 31605885 |
Dystonia | 15.00 | 13.01 | 3 | 75227 | 10222 | 31611892 |
Haematotoxicity | 14.95 | 13.01 | 44 | 75186 | 7093 | 31615021 |
Light chain analysis decreased | 14.92 | 13.01 | 5 | 75225 | 35 | 31622079 |
Inflammation | 14.90 | 13.01 | 23 | 75207 | 25218 | 31596896 |
HCoV-OC43 infection | 14.79 | 13.01 | 5 | 75225 | 36 | 31622078 |
Adenovirus infection | 14.79 | 13.01 | 34 | 75196 | 4720 | 31617394 |
Morganella infection | 14.68 | 13.01 | 11 | 75219 | 489 | 31621625 |
Refractory cytopenia with multilineage dysplasia | 14.62 | 13.01 | 7 | 75223 | 134 | 31621980 |
Plasmablastic lymphoma | 14.54 | 13.01 | 9 | 75221 | 291 | 31621823 |
Peripheral swelling | 14.50 | 13.01 | 234 | 74996 | 67631 | 31554483 |
Ventricular fibrillation | 14.48 | 13.01 | 14 | 75216 | 18834 | 31603280 |
Bacterial sepsis | 14.44 | 13.01 | 34 | 75196 | 4794 | 31617320 |
Blood culture positive | 14.43 | 13.01 | 33 | 75197 | 4565 | 31617549 |
Body height decreased | 14.29 | 13.01 | 28 | 75202 | 3479 | 31618635 |
Drug ineffective | 14.25 | 13.01 | 781 | 74449 | 394792 | 31227322 |
Blood triglycerides increased | 14.21 | 13.01 | 7 | 75223 | 13390 | 31608724 |
Hepatitis | 14.11 | 13.01 | 19 | 75211 | 22047 | 31600067 |
Cellulitis orbital | 14.06 | 13.01 | 9 | 75221 | 309 | 31621805 |
Bladder sphincter atony | 13.99 | 13.01 | 4 | 75226 | 15 | 31622099 |
Refractory anaemia with an excess of blasts | 13.95 | 13.01 | 10 | 75220 | 415 | 31621699 |
Agranulocytosis | 13.89 | 13.01 | 18 | 75212 | 21229 | 31600885 |
Pregnancy of partner | 13.88 | 13.01 | 9 | 75221 | 316 | 31621798 |
Mantle cell lymphoma | 13.86 | 13.01 | 19 | 75211 | 1753 | 31620361 |
Colitis | 13.84 | 13.01 | 132 | 75098 | 33755 | 31588359 |
VIth nerve paresis | 13.82 | 13.01 | 5 | 75225 | 45 | 31622069 |
Therapy interrupted | 13.80 | 13.01 | 4 | 75226 | 10592 | 31611522 |
Hepatotoxicity | 13.79 | 13.01 | 15 | 75215 | 19111 | 31603003 |
Serratia sepsis | 13.78 | 13.01 | 4 | 75226 | 16 | 31622098 |
Chest pain | 13.77 | 13.01 | 195 | 75035 | 116762 | 31505352 |
International normalised ratio increased | 13.65 | 13.01 | 58 | 75172 | 45165 | 31576949 |
Blood glucose increased | 13.57 | 13.01 | 87 | 75143 | 60996 | 31561118 |
Hepatitis B | 13.43 | 13.01 | 37 | 75193 | 5744 | 31616370 |
Speech disorder | 13.40 | 13.01 | 23 | 75207 | 24178 | 31597936 |
Pleural effusion | 13.37 | 13.01 | 251 | 74979 | 74669 | 31547445 |
Muscle spasms | 13.29 | 13.01 | 232 | 74998 | 68086 | 31554028 |
Iron deficiency anaemia | 13.21 | 13.01 | 3 | 75227 | 9356 | 31612758 |
Dyspnoea | 13.14 | 13.01 | 674 | 74556 | 342805 | 31279309 |
Blastic plasmacytoid dendritic cell neoplasia | 13.12 | 13.01 | 6 | 75224 | 103 | 31622011 |
Restlessness | 13.12 | 13.01 | 22 | 75208 | 23339 | 31598775 |
Hypercapnic coma | 13.11 | 13.01 | 7 | 75223 | 170 | 31621944 |
Acute myocardial infarction | 13.10 | 13.01 | 69 | 75161 | 50754 | 31571360 |
Myositis | 13.03 | 13.01 | 5 | 75225 | 11089 | 31611025 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Plasma cell myeloma | 11018.79 | 11.89 | 4178 | 107343 | 69023 | 70747900 |
Neuropathy peripheral | 3283.77 | 11.89 | 2194 | 109327 | 124702 | 70692221 |
Plasma cell myeloma recurrent | 1162.49 | 11.89 | 382 | 111139 | 3964 | 70812959 |
Thrombocytopenia | 1070.93 | 11.89 | 1580 | 109941 | 237530 | 70579393 |
Polyneuropathy | 761.53 | 11.89 | 454 | 111067 | 20961 | 70795962 |
Platelet count decreased | 746.04 | 11.89 | 1142 | 110379 | 177080 | 70639843 |
Disease progression | 658.42 | 11.89 | 1006 | 110515 | 155666 | 70661257 |
Plasmacytoma | 615.73 | 11.89 | 234 | 111287 | 3820 | 70813103 |
Pneumonia | 615.34 | 11.89 | 2193 | 109328 | 594039 | 70222884 |
Rheumatoid arthritis | 441.65 | 11.89 | 3 | 111518 | 291802 | 70525121 |
Plasma cell leukaemia | 388.40 | 11.89 | 136 | 111385 | 1735 | 70815188 |
Completed suicide | 331.34 | 11.89 | 5 | 111516 | 227130 | 70589793 |
Neutropenia | 327.09 | 11.89 | 1017 | 110504 | 256139 | 70560784 |
Unevaluable event | 326.48 | 11.89 | 406 | 111115 | 51657 | 70765266 |
Tumour lysis syndrome | 293.71 | 11.89 | 254 | 111267 | 21106 | 70795817 |
Arthralgia | 272.51 | 11.89 | 235 | 111286 | 503155 | 70313768 |
Headache | 269.51 | 11.89 | 310 | 111211 | 580095 | 70236828 |
Diarrhoea | 263.23 | 11.89 | 2114 | 109407 | 781227 | 70035696 |
Amyloidosis | 262.24 | 11.89 | 114 | 111407 | 2665 | 70814258 |
Pancytopenia | 246.59 | 11.89 | 654 | 110867 | 150453 | 70666470 |
Drug interaction | 244.17 | 11.89 | 149 | 111372 | 381292 | 70435631 |
Plasma cell myeloma refractory | 241.85 | 11.89 | 58 | 111463 | 153 | 70816770 |
Peripheral sensory neuropathy | 241.26 | 11.89 | 179 | 111342 | 11931 | 70804992 |
White blood cell count decreased | 238.80 | 11.89 | 697 | 110824 | 169444 | 70647479 |
Drug hypersensitivity | 235.60 | 11.89 | 61 | 111460 | 262398 | 70554525 |
Off label use | 228.39 | 11.89 | 1966 | 109555 | 741094 | 70075829 |
Product use in unapproved indication | 226.22 | 11.89 | 779 | 110742 | 206699 | 70610224 |
Sepsis | 215.39 | 11.89 | 857 | 110664 | 243688 | 70573235 |
Orthostatic hypotension | 213.72 | 11.89 | 330 | 111191 | 51413 | 70765510 |
Primary amyloidosis | 205.66 | 11.89 | 51 | 111470 | 162 | 70816761 |
Constipation | 194.37 | 11.89 | 849 | 110672 | 251589 | 70565334 |
Deep vein thrombosis | 191.73 | 11.89 | 491 | 111030 | 110551 | 70706372 |
Synovitis | 187.72 | 11.89 | 3 | 111518 | 129225 | 70687698 |
Herpes zoster | 176.14 | 11.89 | 404 | 111117 | 84831 | 70732092 |
Contraindicated product administered | 174.42 | 11.89 | 9 | 111512 | 134603 | 70682320 |
Pain | 163.01 | 11.89 | 480 | 111041 | 628336 | 70188587 |
Drug abuse | 162.75 | 11.89 | 20 | 111501 | 147236 | 70669687 |
Septic shock | 160.38 | 11.89 | 463 | 111058 | 111795 | 70705128 |
Myelodysplastic syndrome | 158.11 | 11.89 | 214 | 111307 | 29571 | 70787352 |
Overdose | 157.02 | 11.89 | 37 | 111484 | 169708 | 70647215 |
Autonomic neuropathy | 156.66 | 11.89 | 69 | 111452 | 1666 | 70815257 |
Cytopenia | 155.96 | 11.89 | 163 | 111358 | 17160 | 70799763 |
Maternal exposure during pregnancy | 155.04 | 11.89 | 6 | 111515 | 115339 | 70701584 |
Febrile neutropenia | 149.49 | 11.89 | 677 | 110844 | 203641 | 70613282 |
Cardiac amyloidosis | 146.24 | 11.89 | 64 | 111457 | 1521 | 70815402 |
Systemic lupus erythematosus | 145.40 | 11.89 | 3 | 111518 | 101899 | 70715024 |
Alopecia | 142.27 | 11.89 | 67 | 111454 | 198423 | 70618500 |
Arthropathy | 140.19 | 11.89 | 32 | 111489 | 150025 | 70666898 |
Light chain analysis increased | 137.37 | 11.89 | 60 | 111461 | 1419 | 70815504 |
Chalazion | 136.93 | 11.89 | 44 | 111477 | 422 | 70816501 |
Ileus paralytic | 136.53 | 11.89 | 112 | 111409 | 8649 | 70808274 |
Psoriasis | 136.25 | 11.89 | 4 | 111517 | 98429 | 70718494 |
Joint swelling | 134.56 | 11.89 | 120 | 111401 | 253091 | 70563832 |
Atrial fibrillation | 129.76 | 11.89 | 604 | 110917 | 183744 | 70633179 |
Neutrophil count decreased | 128.50 | 11.89 | 354 | 111167 | 83202 | 70733721 |
Therapy partial responder | 128.04 | 11.89 | 126 | 111395 | 12348 | 70804575 |
Anaemia | 127.83 | 11.89 | 1076 | 110445 | 402347 | 70414576 |
Condition aggravated | 126.09 | 11.89 | 306 | 111215 | 427329 | 70389594 |
Dehydration | 125.53 | 11.89 | 693 | 110828 | 225449 | 70591474 |
Therapeutic product effect decreased | 121.26 | 11.89 | 37 | 111484 | 142981 | 70673942 |
Exposure during pregnancy | 119.84 | 11.89 | 4 | 111517 | 87713 | 70729210 |
Musculoskeletal stiffness | 118.65 | 11.89 | 42 | 111479 | 147718 | 70669205 |
Hypersensitivity | 118.43 | 11.89 | 112 | 111409 | 229700 | 70587223 |
Glossodynia | 117.96 | 11.89 | 4 | 111517 | 86483 | 70730440 |
Full blood count decreased | 116.68 | 11.89 | 165 | 111356 | 23753 | 70793170 |
Pyrexia | 111.16 | 11.89 | 1448 | 110073 | 605504 | 70211419 |
Hypercalcaemia | 110.59 | 11.89 | 196 | 111325 | 34189 | 70782734 |
Anxiety | 110.49 | 11.89 | 110 | 111411 | 220220 | 70596703 |
Swelling | 109.27 | 11.89 | 82 | 111439 | 188457 | 70628466 |
Blood pressure increased | 105.44 | 11.89 | 85 | 111436 | 188432 | 70628491 |
Renal failure | 101.30 | 11.89 | 574 | 110947 | 188496 | 70628427 |
Abdominal discomfort | 101.09 | 11.89 | 113 | 111408 | 214545 | 70602378 |
Suicide attempt | 100.86 | 11.89 | 6 | 111515 | 79504 | 70737419 |
Product use issue | 99.53 | 11.89 | 551 | 110970 | 179386 | 70637537 |
Posterior reversible encephalopathy syndrome | 97.06 | 11.89 | 153 | 111368 | 24249 | 70792674 |
Wound | 96.41 | 11.89 | 19 | 111502 | 98713 | 70718210 |
Malignant neoplasm progression | 93.94 | 11.89 | 410 | 111111 | 121329 | 70695594 |
Discomfort | 93.57 | 11.89 | 25 | 111496 | 105411 | 70711512 |
Mobility decreased | 90.32 | 11.89 | 25 | 111496 | 102974 | 70713949 |
Injection site pain | 88.50 | 11.89 | 37 | 111484 | 117582 | 70699341 |
Stem cell transplant | 85.20 | 11.89 | 59 | 111462 | 3526 | 70813397 |
Peripheral sensorimotor neuropathy | 84.66 | 11.89 | 53 | 111468 | 2669 | 70814254 |
Depression | 82.93 | 11.89 | 115 | 111406 | 198859 | 70618064 |
Weight increased | 82.41 | 11.89 | 160 | 111361 | 242171 | 70574752 |
Cytomegalovirus infection | 80.49 | 11.89 | 187 | 111334 | 39571 | 70777352 |
Thrombosis | 80.16 | 11.89 | 281 | 111240 | 75124 | 70741799 |
Hyperviscosity syndrome | 79.06 | 11.89 | 28 | 111493 | 370 | 70816553 |
Rhabdomyolysis | 78.97 | 11.89 | 26 | 111495 | 95734 | 70721189 |
Malaise | 78.42 | 11.89 | 382 | 111139 | 432550 | 70384373 |
Hepatitis B reactivation | 78.33 | 11.89 | 66 | 111455 | 5289 | 70811634 |
Hypertension | 75.71 | 11.89 | 227 | 111294 | 295806 | 70521117 |
Pathological fracture | 75.43 | 11.89 | 84 | 111437 | 9499 | 70807424 |
Osteonecrosis of jaw | 74.56 | 11.89 | 185 | 111336 | 40817 | 70776106 |
Bone marrow failure | 72.71 | 11.89 | 205 | 111316 | 48805 | 70768118 |
Wrong technique in product usage process | 71.93 | 11.89 | 11 | 111510 | 68687 | 70748236 |
Monoclonal immunoglobulin present | 71.90 | 11.89 | 33 | 111488 | 880 | 70816043 |
Peripheral motor neuropathy | 70.82 | 11.89 | 50 | 111471 | 3082 | 70813841 |
Blood pressure fluctuation | 70.39 | 11.89 | 6 | 111515 | 59006 | 70757917 |
Cystitis haemorrhagic | 68.80 | 11.89 | 76 | 111445 | 8517 | 70808406 |
Inappropriate schedule of product administration | 68.68 | 11.89 | 42 | 111479 | 107513 | 70709410 |
Cytomegalovirus infection reactivation | 68.67 | 11.89 | 68 | 111453 | 6713 | 70810210 |
Stress | 68.66 | 11.89 | 12 | 111509 | 67954 | 70748969 |
Spinal cord compression | 68.64 | 11.89 | 64 | 111457 | 5864 | 70811059 |
Pleural effusion | 68.26 | 11.89 | 399 | 111122 | 132465 | 70684458 |
Helicobacter infection | 68.23 | 11.89 | 5 | 111516 | 55651 | 70761272 |
B precursor type acute leukaemia | 66.84 | 11.89 | 26 | 111495 | 453 | 70816470 |
Blood stem cell harvest failure | 65.63 | 11.89 | 18 | 111503 | 93 | 70816830 |
Haemoglobin decreased | 64.68 | 11.89 | 547 | 110974 | 204612 | 70612311 |
Treatment failure | 64.48 | 11.89 | 79 | 111442 | 144063 | 70672860 |
Duodenal ulcer perforation | 64.39 | 11.89 | 4 | 111517 | 51108 | 70765815 |
Blood cholesterol increased | 63.98 | 11.89 | 12 | 111509 | 64592 | 70752331 |
Cardiac failure | 63.03 | 11.89 | 414 | 111107 | 143127 | 70673796 |
Protein total increased | 62.95 | 11.89 | 49 | 111472 | 3508 | 70813415 |
Arthritis | 62.93 | 11.89 | 38 | 111483 | 97942 | 70718981 |
Colitis | 62.88 | 11.89 | 232 | 111289 | 63582 | 70753341 |
Pulmonary embolism | 62.74 | 11.89 | 440 | 111081 | 155427 | 70661496 |
Fibromyalgia | 62.63 | 11.89 | 3 | 111518 | 47871 | 70769052 |
Nasopharyngitis | 61.50 | 11.89 | 164 | 111357 | 222042 | 70594881 |
Blood creatine phosphokinase increased | 61.49 | 11.89 | 11 | 111510 | 61252 | 70755671 |
Guillain-Barre syndrome | 60.76 | 11.89 | 69 | 111452 | 7971 | 70808952 |
Hordeolum | 60.16 | 11.89 | 42 | 111479 | 2543 | 70814380 |
Therapy non-responder | 59.27 | 11.89 | 259 | 111262 | 76656 | 70740267 |
Blister | 59.14 | 11.89 | 43 | 111478 | 100483 | 70716440 |
Osteolysis | 59.09 | 11.89 | 47 | 111474 | 3472 | 70813451 |
Coombs indirect test positive | 58.83 | 11.89 | 15 | 111506 | 55 | 70816868 |
Ileus | 58.10 | 11.89 | 122 | 111399 | 24115 | 70792808 |
Hepatic enzyme increased | 57.49 | 11.89 | 99 | 111422 | 156891 | 70660032 |
Migraine | 57.17 | 11.89 | 21 | 111500 | 72217 | 70744706 |
Flushing | 56.92 | 11.89 | 29 | 111492 | 82143 | 70734780 |
Hypogammaglobulinaemia | 56.87 | 11.89 | 80 | 111441 | 11458 | 70805465 |
Blood lactate dehydrogenase increased | 56.14 | 11.89 | 151 | 111370 | 34976 | 70781947 |
Haematotoxicity | 56.13 | 11.89 | 87 | 111434 | 13587 | 70803336 |
Irritable bowel syndrome | 55.93 | 11.89 | 7 | 111514 | 50843 | 70766080 |
Acute myeloid leukaemia | 55.62 | 11.89 | 139 | 111382 | 30801 | 70786122 |
Morganella infection | 54.45 | 11.89 | 29 | 111492 | 1073 | 70815850 |
Wheezing | 51.95 | 11.89 | 43 | 111478 | 94127 | 70722796 |
Injury | 51.58 | 11.89 | 19 | 111502 | 65226 | 70751697 |
Plasmablastic lymphoma | 51.48 | 11.89 | 23 | 111498 | 575 | 70816348 |
Acute lymphocytic leukaemia | 51.38 | 11.89 | 53 | 111468 | 5492 | 70811431 |
Asthma | 51.13 | 11.89 | 69 | 111452 | 120724 | 70696199 |
Bacteraemia | 49.90 | 11.89 | 129 | 111392 | 29180 | 70787743 |
Suicidal ideation | 49.05 | 11.89 | 24 | 111497 | 69572 | 70747351 |
Pericarditis | 48.83 | 11.89 | 37 | 111484 | 84668 | 70732255 |
Red blood cell sedimentation rate increased | 48.75 | 11.89 | 3 | 111518 | 38639 | 70778284 |
Metapneumovirus infection | 48.29 | 11.89 | 30 | 111491 | 1490 | 70815433 |
Gastrooesophageal reflux disease | 48.25 | 11.89 | 43 | 111478 | 90796 | 70726127 |
Anaphylactic reaction | 48.25 | 11.89 | 29 | 111492 | 74945 | 70741978 |
Sedation | 47.75 | 11.89 | 8 | 111513 | 46723 | 70770200 |
Compression fracture | 47.70 | 11.89 | 53 | 111468 | 5978 | 70810945 |
Renal amyloidosis | 47.43 | 11.89 | 15 | 111506 | 136 | 70816787 |
Osteoarthritis | 47.27 | 11.89 | 29 | 111492 | 74118 | 70742805 |
Pruritus | 47.01 | 11.89 | 334 | 111187 | 345226 | 70471697 |
Bone pain | 46.94 | 11.89 | 181 | 111340 | 50641 | 70766282 |
Ill-defined disorder | 46.67 | 11.89 | 14 | 111507 | 54727 | 70762196 |
Hypocalcaemia | 46.66 | 11.89 | 166 | 111355 | 44693 | 70772230 |
Blood pressure systolic increased | 46.41 | 11.89 | 16 | 111505 | 57243 | 70759680 |
Squamous cell carcinoma of skin | 45.51 | 11.89 | 76 | 111445 | 12636 | 70804287 |
Loss of personal independence in daily activities | 45.33 | 11.89 | 40 | 111481 | 84870 | 70732053 |
Somnolence | 45.17 | 11.89 | 180 | 111341 | 215426 | 70601497 |
Myalgia | 44.14 | 11.89 | 127 | 111394 | 167765 | 70649158 |
Erythema | 43.47 | 11.89 | 164 | 111357 | 199399 | 70617524 |
Pneumonia fungal | 43.22 | 11.89 | 65 | 111456 | 9888 | 70807035 |
Heart rate increased | 42.57 | 11.89 | 63 | 111458 | 106085 | 70710838 |
Sleep disorder | 42.26 | 11.89 | 29 | 111492 | 69843 | 70747080 |
Syncope | 42.16 | 11.89 | 422 | 111099 | 165287 | 70651636 |
Aggression | 42.01 | 11.89 | 12 | 111509 | 48434 | 70768489 |
Folliculitis | 41.96 | 11.89 | 8 | 111513 | 42562 | 70774361 |
Neuralgia | 41.79 | 11.89 | 119 | 111402 | 28484 | 70788439 |
Drug intolerance | 41.44 | 11.89 | 198 | 111323 | 225489 | 70591434 |
Nasal congestion | 41.43 | 11.89 | 26 | 111495 | 65646 | 70751277 |
Asthenia | 41.35 | 11.89 | 976 | 110545 | 456690 | 70360233 |
Inflammation | 40.87 | 11.89 | 38 | 111483 | 78627 | 70738296 |
Contusion | 40.55 | 11.89 | 88 | 111433 | 127948 | 70688975 |
BK virus infection | 40.28 | 11.89 | 56 | 111465 | 7933 | 70808990 |
Crossmatch incompatible | 39.81 | 11.89 | 10 | 111511 | 34 | 70816889 |
Large intestine perforation | 39.60 | 11.89 | 73 | 111448 | 13122 | 70803801 |
Spinal compression fracture | 39.29 | 11.89 | 80 | 111441 | 15473 | 70801450 |
Performance status decreased | 38.86 | 11.89 | 46 | 111475 | 5555 | 70811368 |
Refractory cytopenia with multilineage dysplasia | 38.79 | 11.89 | 15 | 111506 | 257 | 70816666 |
Drug ineffective | 38.57 | 11.89 | 1155 | 110366 | 938597 | 69878326 |
Thrombotic microangiopathy | 38.39 | 11.89 | 86 | 111435 | 17762 | 70799161 |
Hyperhidrosis | 38.01 | 11.89 | 95 | 111426 | 131491 | 70685432 |
Respiratory failure | 37.89 | 11.89 | 419 | 111102 | 168316 | 70648607 |
Sopor | 37.78 | 11.89 | 3 | 111518 | 31264 | 70785659 |
Mantle cell lymphoma | 37.62 | 11.89 | 27 | 111494 | 1708 | 70815215 |
Urticaria | 37.48 | 11.89 | 131 | 111390 | 162918 | 70654005 |
Colitis ulcerative | 36.51 | 11.89 | 5 | 111516 | 33918 | 70783005 |
Progressive multifocal leukoencephalopathy | 36.31 | 11.89 | 88 | 111433 | 19126 | 70797797 |
Diverticular perforation | 36.21 | 11.89 | 44 | 111477 | 5460 | 70811463 |
Abdominal pain upper | 36.04 | 11.89 | 169 | 111352 | 193433 | 70623490 |
Palpitations | 36.01 | 11.89 | 75 | 111446 | 110678 | 70706245 |
Osteoporosis | 35.80 | 11.89 | 16 | 111505 | 48891 | 70768032 |
Inappropriate antidiuretic hormone secretion | 35.14 | 11.89 | 98 | 111423 | 23178 | 70793745 |
Cough | 34.89 | 11.89 | 335 | 111186 | 325042 | 70491881 |
JC virus infection | 34.83 | 11.89 | 35 | 111486 | 3516 | 70813407 |
Drug withdrawal syndrome | 34.79 | 11.89 | 5 | 111516 | 32710 | 70784213 |
Respiratory tract infection | 34.37 | 11.89 | 145 | 111376 | 42253 | 70774670 |
Sinusitis | 34.33 | 11.89 | 143 | 111378 | 169052 | 70647871 |
Infection | 34.32 | 11.89 | 493 | 111028 | 210292 | 70606631 |
Large intestinal ulcer perforation | 34.26 | 11.89 | 10 | 111511 | 67 | 70816856 |
Neurotoxicity | 34.18 | 11.89 | 114 | 111407 | 29712 | 70787211 |
Impaired healing | 34.05 | 11.89 | 40 | 111481 | 74334 | 70742589 |
Abdominal pain | 33.49 | 11.89 | 360 | 111161 | 341767 | 70475156 |
Bacterial sepsis | 33.29 | 11.89 | 50 | 111471 | 7597 | 70809326 |
Hypophosphataemia | 33.27 | 11.89 | 77 | 111444 | 16249 | 70800674 |
Lactic acidosis | 33.09 | 11.89 | 32 | 111489 | 64992 | 70751931 |
Type 2 diabetes mellitus | 32.93 | 11.89 | 14 | 111507 | 44066 | 70772857 |
Demyelinating polyneuropathy | 32.69 | 11.89 | 24 | 111497 | 1573 | 70815350 |
End stage renal disease | 32.67 | 11.89 | 61 | 111460 | 11072 | 70805851 |
Lymphopenia | 32.63 | 11.89 | 106 | 111415 | 27253 | 70789670 |
Underdose | 32.42 | 11.89 | 4 | 111517 | 29379 | 70787544 |
Rash | 32.29 | 11.89 | 1040 | 110481 | 509522 | 70307401 |
Mesenteric abscess | 32.02 | 11.89 | 11 | 111510 | 132 | 70816791 |
VIth nerve paresis | 31.94 | 11.89 | 11 | 111510 | 133 | 70816790 |
Prescribed overdose | 31.78 | 11.89 | 3 | 111518 | 27178 | 70789745 |
Pneumonia pneumococcal | 31.51 | 11.89 | 33 | 111488 | 3481 | 70813442 |
Obesity | 31.18 | 11.89 | 3 | 111518 | 26768 | 70790155 |
Seizure | 31.01 | 11.89 | 159 | 111362 | 177803 | 70639120 |
Nasal abscess | 30.95 | 11.89 | 11 | 111510 | 147 | 70816776 |
Pain in extremity | 30.60 | 11.89 | 349 | 111172 | 327733 | 70489190 |
Hypoglycaemia | 30.59 | 11.89 | 64 | 111457 | 94300 | 70722623 |
Nocardiosis | 30.54 | 11.89 | 39 | 111482 | 5090 | 70811833 |
Hip arthroplasty | 30.50 | 11.89 | 4 | 111517 | 28036 | 70788887 |
Injection site swelling | 30.23 | 11.89 | 15 | 111506 | 43142 | 70773781 |
Blepharitis | 30.14 | 11.89 | 29 | 111492 | 2764 | 70814159 |
Endocarditis bacterial | 30.10 | 11.89 | 22 | 111499 | 1432 | 70815491 |
Toxicity to various agents | 30.03 | 11.89 | 800 | 110721 | 381372 | 70435551 |
Clostridium difficile colitis | 29.89 | 11.89 | 107 | 111414 | 28889 | 70788034 |
Blood immunoglobulin A increased | 29.89 | 11.89 | 16 | 111505 | 598 | 70816325 |
Heart rate decreased | 29.87 | 11.89 | 32 | 111489 | 61983 | 70754940 |
Hepatitis B | 29.70 | 11.89 | 49 | 111472 | 8065 | 70808858 |
Product quality issue | 29.58 | 11.89 | 6 | 111515 | 30555 | 70786368 |
Visceral leishmaniasis | 29.32 | 11.89 | 19 | 111502 | 1016 | 70815907 |
Ageusia | 29.09 | 11.89 | 69 | 111452 | 14793 | 70802130 |
Dysarthria | 29.08 | 11.89 | 33 | 111488 | 62280 | 70754643 |
Hypothyroidism | 29.02 | 11.89 | 18 | 111503 | 45737 | 70771186 |
Meningitis listeria | 28.83 | 11.89 | 18 | 111503 | 902 | 70816021 |
Hypoalbuminaemia | 28.37 | 11.89 | 80 | 111441 | 19042 | 70797881 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 28.35 | 11.89 | 19 | 111502 | 1076 | 70815847 |
Incorrect dose administered | 28.34 | 11.89 | 38 | 111483 | 66681 | 70750242 |
Rib fracture | 28.25 | 11.89 | 96 | 111425 | 25260 | 70791663 |
Mucosal inflammation | 28.13 | 11.89 | 193 | 111328 | 67657 | 70749266 |
Drug-induced liver injury | 28.11 | 11.89 | 28 | 111493 | 56085 | 70760838 |
H1N1 influenza | 28.05 | 11.89 | 26 | 111495 | 2364 | 70814559 |
Oedema peripheral | 27.96 | 11.89 | 509 | 111012 | 227582 | 70589341 |
Osteonecrosis | 27.87 | 11.89 | 105 | 111416 | 29055 | 70787868 |
Cerebellar haemangioma | 27.85 | 11.89 | 9 | 111512 | 88 | 70816835 |
Liver injury | 27.65 | 11.89 | 15 | 111506 | 41020 | 70775903 |
Oroantral fistula | 27.25 | 11.89 | 13 | 111508 | 379 | 70816544 |
Feeling abnormal | 27.21 | 11.89 | 123 | 111398 | 142196 | 70674727 |
Dry mouth | 27.11 | 11.89 | 43 | 111478 | 70414 | 70746509 |
Taste disorder | 26.93 | 11.89 | 57 | 111464 | 11328 | 70805595 |
Enterococcal infection | 26.72 | 11.89 | 66 | 111455 | 14516 | 70802407 |
Body dysmorphic disorder | 26.71 | 11.89 | 12 | 111509 | 304 | 70816619 |
Multiple sclerosis | 26.58 | 11.89 | 4 | 111517 | 25281 | 70791642 |
Failure to thrive | 26.52 | 11.89 | 55 | 111466 | 10774 | 70806149 |
Hyperproteinaemia | 26.43 | 11.89 | 10 | 111511 | 161 | 70816762 |
Pneumonia cytomegaloviral | 26.09 | 11.89 | 34 | 111487 | 4527 | 70812396 |
Rectal adenocarcinoma | 26.09 | 11.89 | 20 | 111501 | 1400 | 70815523 |
Blood immunoglobulin G increased | 26.01 | 11.89 | 23 | 111498 | 1967 | 70814956 |
Autonomic nervous system imbalance | 25.84 | 11.89 | 33 | 111488 | 4306 | 70812617 |
Hiccups | 25.82 | 11.89 | 49 | 111472 | 9003 | 70807920 |
Iron deficiency anaemia | 25.80 | 11.89 | 3 | 111518 | 23069 | 70793854 |
Meningitis pneumococcal | 25.66 | 11.89 | 13 | 111508 | 433 | 70816490 |
Musculoskeletal pain | 25.47 | 11.89 | 66 | 111455 | 90261 | 70726662 |
Joint range of motion decreased | 25.42 | 11.89 | 5 | 111516 | 26021 | 70790902 |
Depressed level of consciousness | 25.34 | 11.89 | 63 | 111458 | 87368 | 70729555 |
Angioedema | 25.30 | 11.89 | 41 | 111480 | 66569 | 70750354 |
Drug reaction with eosinophilia and systemic symptoms | 25.24 | 11.89 | 167 | 111354 | 57846 | 70759077 |
Diabetic ketoacidosis | 25.20 | 11.89 | 9 | 111512 | 31503 | 70785420 |
Oropharyngeal pain | 25.19 | 11.89 | 73 | 111448 | 96237 | 70720686 |
Fungal oesophagitis | 25.15 | 11.89 | 16 | 111505 | 829 | 70816094 |
Lip swelling | 25.14 | 11.89 | 11 | 111510 | 34043 | 70782880 |
Myelosuppression | 25.14 | 11.89 | 104 | 111417 | 30041 | 70786882 |
Gait disturbance | 25.09 | 11.89 | 179 | 111342 | 184927 | 70631996 |
Target skin lesion | 25.07 | 11.89 | 9 | 111512 | 124 | 70816799 |
Respirovirus test positive | 25.00 | 11.89 | 9 | 111512 | 125 | 70816798 |
Oral surgery | 25.00 | 11.89 | 17 | 111504 | 986 | 70815937 |
Accidental overdose | 24.91 | 11.89 | 12 | 111509 | 35109 | 70781814 |
Dyskinesia | 24.90 | 11.89 | 17 | 111504 | 41057 | 70775866 |
VIth nerve paralysis | 24.79 | 11.89 | 20 | 111501 | 1508 | 70815415 |
Chest discomfort | 24.68 | 11.89 | 106 | 111415 | 124275 | 70692648 |
Adenocarcinoma of colon | 24.54 | 11.89 | 36 | 111485 | 5356 | 70811567 |
Blastic plasmacytoid dendritic cell neoplasia | 24.43 | 11.89 | 9 | 111512 | 134 | 70816789 |
Gastrointestinal fungal infection | 24.36 | 11.89 | 12 | 111509 | 376 | 70816547 |
COVID-19 pneumonia | 24.32 | 11.89 | 83 | 111438 | 21886 | 70795037 |
Swollen tongue | 24.30 | 11.89 | 14 | 111507 | 37032 | 70779891 |
Refractory anaemia with an excess of blasts | 24.26 | 11.89 | 16 | 111505 | 882 | 70816041 |
Depressed mood | 24.17 | 11.89 | 20 | 111501 | 43800 | 70773123 |
Clostridium bacteraemia | 23.80 | 11.89 | 11 | 111510 | 298 | 70816625 |
Respiratory depression | 23.77 | 11.89 | 5 | 111516 | 24826 | 70792097 |
Dyspepsia | 23.68 | 11.89 | 67 | 111454 | 89010 | 70727913 |
Throat irritation | 23.65 | 11.89 | 13 | 111508 | 35291 | 70781632 |
Bradycardia | 23.64 | 11.89 | 108 | 111413 | 124507 | 70692416 |
Death | 23.50 | 11.89 | 1003 | 110518 | 509058 | 70307865 |
Bacterial infection | 23.36 | 11.89 | 93 | 111428 | 26399 | 70790524 |
Nephrolithiasis | 23.26 | 11.89 | 24 | 111497 | 47299 | 70769624 |
Parainfluenzae virus infection | 23.24 | 11.89 | 34 | 111487 | 5046 | 70811877 |
Escherichia sepsis | 22.97 | 11.89 | 42 | 111479 | 7501 | 70809422 |
Acute febrile neutrophilic dermatosis | 22.94 | 11.89 | 28 | 111493 | 3491 | 70813432 |
Electrocardiogram QT prolonged | 22.81 | 11.89 | 62 | 111459 | 83455 | 70733468 |
Hypersensitivity myocarditis | 22.71 | 11.89 | 8 | 111513 | 104 | 70816819 |
Electrolyte imbalance | 22.66 | 11.89 | 93 | 111428 | 26768 | 70790155 |
Basal cell carcinoma | 22.63 | 11.89 | 109 | 111412 | 33589 | 70783334 |
Medication error | 22.60 | 11.89 | 34 | 111487 | 56878 | 70760045 |
Pneumonia influenzal | 22.49 | 11.89 | 24 | 111497 | 2586 | 70814337 |
Pseudomonal sepsis | 22.41 | 11.89 | 35 | 111486 | 5502 | 70811421 |
Hot flush | 22.34 | 11.89 | 27 | 111494 | 49557 | 70767366 |
Coma | 22.32 | 11.89 | 72 | 111449 | 91772 | 70725151 |
Pallor | 22.23 | 11.89 | 19 | 111502 | 40955 | 70775968 |
Blood potassium decreased | 22.15 | 11.89 | 128 | 111393 | 42293 | 70774630 |
Pseudomyopia | 21.99 | 11.89 | 7 | 111514 | 65 | 70816858 |
Therapy interrupted | 21.77 | 11.89 | 6 | 111515 | 24796 | 70792127 |
Neutropenic sepsis | 21.77 | 11.89 | 87 | 111434 | 24743 | 70792180 |
Hypoaesthesia | 21.70 | 11.89 | 351 | 111170 | 153388 | 70663535 |
Superficial spreading melanoma stage unspecified | 21.50 | 11.89 | 10 | 111511 | 275 | 70816648 |
Blood culture positive | 21.50 | 11.89 | 42 | 111479 | 7884 | 70809039 |
Toxic skin eruption | 21.30 | 11.89 | 75 | 111446 | 20087 | 70796836 |
Disturbance in social behaviour | 21.24 | 11.89 | 29 | 111492 | 4038 | 70812885 |
Acute respiratory distress syndrome | 21.23 | 11.89 | 124 | 111397 | 41130 | 70775793 |
Conjunctival irritation | 21.19 | 11.89 | 8 | 111513 | 128 | 70816795 |
Neurogenic bladder | 21.15 | 11.89 | 28 | 111493 | 3785 | 70813138 |
Pulmonary oedema | 21.13 | 11.89 | 210 | 111311 | 82068 | 70734855 |
Meningitis cryptococcal | 20.92 | 11.89 | 26 | 111495 | 3302 | 70813621 |
Memory impairment | 20.90 | 11.89 | 75 | 111446 | 92566 | 70724357 |
Crying | 20.85 | 11.89 | 4 | 111517 | 21195 | 70795728 |
Hallucination, visual | 20.84 | 11.89 | 10 | 111511 | 29327 | 70787596 |
Accidental exposure to product | 20.81 | 11.89 | 9 | 111512 | 28042 | 70788881 |
Mantle cell lymphoma recurrent | 20.80 | 11.89 | 12 | 111509 | 520 | 70816403 |
Frequent bowel movements | 20.79 | 11.89 | 4 | 111517 | 21149 | 70795774 |
Lung infiltration | 20.78 | 11.89 | 78 | 111443 | 21546 | 70795377 |
Pulmonary arterial hypertension | 20.73 | 11.89 | 13 | 111508 | 32842 | 70784081 |
Bursitis | 20.69 | 11.89 | 8 | 111513 | 26665 | 70790258 |
Laboratory test abnormal | 20.68 | 11.89 | 88 | 111433 | 25735 | 70791188 |
N-terminal prohormone brain natriuretic peptide decreased | 20.63 | 11.89 | 5 | 111516 | 14 | 70816909 |
Device dislocation | 20.61 | 11.89 | 5 | 111516 | 22502 | 70794421 |
Leukaemia | 20.41 | 11.89 | 33 | 111488 | 5342 | 70811581 |
Irritability | 20.41 | 11.89 | 18 | 111503 | 38207 | 70778716 |
Bronchopulmonary aspergillosis | 20.38 | 11.89 | 76 | 111445 | 20926 | 70795997 |
Extrapyramidal disorder | 20.23 | 11.89 | 4 | 111517 | 20746 | 70796177 |
Acne | 20.22 | 11.89 | 7 | 111514 | 24982 | 70791941 |
Injection site bruising | 20.20 | 11.89 | 18 | 111503 | 38014 | 70778909 |
Bone lesion | 20.16 | 11.89 | 33 | 111488 | 5397 | 70811526 |
Surgery | 20.15 | 11.89 | 11 | 111510 | 29978 | 70786945 |
Dyspnoea | 20.10 | 11.89 | 998 | 110523 | 769062 | 70047861 |
Chromaturia | 20.08 | 11.89 | 6 | 111515 | 23522 | 70793401 |
Amnesia | 19.90 | 11.89 | 32 | 111489 | 52123 | 70764800 |
Light chain analysis abnormal | 19.88 | 11.89 | 8 | 111513 | 153 | 70816770 |
Refractory cancer | 19.78 | 11.89 | 9 | 111512 | 235 | 70816688 |
Bronchiolitis | 19.62 | 11.89 | 27 | 111494 | 3787 | 70813136 |
Visual impairment | 19.44 | 11.89 | 63 | 111458 | 80187 | 70736736 |
Fatigue | 19.36 | 11.89 | 1525 | 109996 | 822794 | 69994129 |
Sinus polyp | 19.36 | 11.89 | 11 | 111510 | 463 | 70816460 |
Hyperthyroidism | 19.33 | 11.89 | 4 | 111517 | 20087 | 70796836 |
General physical condition abnormal | 19.29 | 11.89 | 34 | 111487 | 5902 | 70811021 |
Transplant | 18.93 | 11.89 | 14 | 111507 | 928 | 70815995 |
Torsade de pointes | 18.74 | 11.89 | 3 | 111518 | 18113 | 70798810 |
Peritonitis viral | 18.72 | 11.89 | 6 | 111515 | 57 | 70816866 |
Rhinovirus infection | 18.65 | 11.89 | 36 | 111485 | 6697 | 70810226 |
Graft versus host disease | 18.64 | 11.89 | 59 | 111462 | 14964 | 70801959 |
Polyomavirus-associated nephropathy | 18.57 | 11.89 | 31 | 111490 | 5152 | 70811771 |
Tooth deposit | 18.57 | 11.89 | 9 | 111512 | 272 | 70816651 |
Adenovirus infection | 18.50 | 11.89 | 39 | 111482 | 7729 | 70809194 |
Brief psychotic disorder with marked stressors | 18.36 | 11.89 | 9 | 111512 | 279 | 70816644 |
COVID-19 | 18.26 | 11.89 | 250 | 111271 | 105507 | 70711416 |
Intentional product misuse | 18.25 | 11.89 | 64 | 111457 | 79531 | 70737392 |
Varicella | 18.14 | 11.89 | 22 | 111499 | 2725 | 70814198 |
Foot deformity | 18.12 | 11.89 | 5 | 111516 | 20650 | 70796273 |
Malignant melanoma in situ | 18.09 | 11.89 | 19 | 111502 | 2010 | 70814913 |
Sleep apnoea syndrome | 17.96 | 11.89 | 15 | 111506 | 32698 | 70784225 |
Cardiac failure congestive | 17.91 | 11.89 | 306 | 111215 | 135151 | 70681772 |
Oncologic complication | 17.90 | 11.89 | 9 | 111512 | 295 | 70816628 |
Intraductal proliferative breast lesion | 17.89 | 11.89 | 20 | 111501 | 2271 | 70814652 |
Neck pain | 17.82 | 11.89 | 50 | 111471 | 66607 | 70750316 |
Product prescribing error | 17.77 | 11.89 | 21 | 111500 | 38931 | 70777992 |
Faeces discoloured | 17.77 | 11.89 | 10 | 111511 | 26799 | 70790124 |
Glycosylated haemoglobin increased | 17.72 | 11.89 | 3 | 111518 | 17388 | 70799535 |
Poor quality sleep | 17.72 | 11.89 | 5 | 111516 | 20344 | 70796579 |
Blood immunoglobulin M increased | 17.64 | 11.89 | 11 | 111510 | 550 | 70816373 |
Atrial flutter | 17.64 | 11.89 | 71 | 111450 | 20256 | 70796667 |
Tachycardia | 17.50 | 11.89 | 162 | 111359 | 158384 | 70658539 |
Plasma cells present | 17.45 | 11.89 | 4 | 111517 | 8 | 70816915 |
Phrenic nerve paralysis | 17.33 | 11.89 | 9 | 111512 | 316 | 70816607 |
Haematochezia | 17.27 | 11.89 | 58 | 111463 | 73023 | 70743900 |
Hypokalaemia | 17.22 | 11.89 | 296 | 111225 | 130892 | 70686031 |
Nodule | 17.21 | 11.89 | 5 | 111516 | 19964 | 70796959 |
Body temperature decreased | 17.20 | 11.89 | 12 | 111509 | 28660 | 70788263 |
Paraesthesia | 17.20 | 11.89 | 323 | 111198 | 145214 | 70671709 |
Gastrointestinal amyloidosis | 17.03 | 11.89 | 6 | 111515 | 78 | 70816845 |
Gastric ulcer | 16.93 | 11.89 | 15 | 111506 | 31775 | 70785148 |
Therapeutic response decreased | 16.90 | 11.89 | 153 | 111368 | 58300 | 70758623 |
Genital erythema | 16.84 | 11.89 | 8 | 111513 | 231 | 70816692 |
Enteric neuropathy | 16.83 | 11.89 | 4 | 111517 | 10 | 70816913 |
Light chain analysis | 16.83 | 11.89 | 4 | 111517 | 10 | 70816913 |
Plasma cells decreased | 16.82 | 11.89 | 5 | 111516 | 36 | 70816887 |
Rash pruritic | 16.77 | 11.89 | 162 | 111359 | 62829 | 70754094 |
Small intestinal obstruction | 16.73 | 11.89 | 80 | 111441 | 24575 | 70792348 |
Disturbance in attention | 16.67 | 11.89 | 26 | 111495 | 42868 | 70774055 |
Cerebral aspergillosis | 16.66 | 11.89 | 17 | 111504 | 1739 | 70815184 |
Myocardial infarction | 16.61 | 11.89 | 181 | 111340 | 171464 | 70645459 |
Stomatitis | 16.58 | 11.89 | 126 | 111395 | 128385 | 70688538 |
Tendonitis | 16.56 | 11.89 | 7 | 111514 | 22115 | 70794808 |
Fear | 16.55 | 11.89 | 6 | 111515 | 20805 | 70796118 |
Renal impairment | 16.51 | 11.89 | 318 | 111203 | 143619 | 70673304 |
Procedural pain | 16.49 | 11.89 | 4 | 111517 | 18005 | 70798918 |
Injection site exfoliation | 16.41 | 11.89 | 7 | 111514 | 156 | 70816767 |
Respiratory arrest | 16.31 | 11.89 | 38 | 111483 | 53895 | 70763028 |
Blood immunoglobulin A decreased | 16.25 | 11.89 | 11 | 111510 | 633 | 70816290 |
Enterococcal sepsis | 16.11 | 11.89 | 20 | 111501 | 2537 | 70814386 |
Staphylococcal bacteraemia | 16.08 | 11.89 | 46 | 111475 | 11036 | 70805887 |
Aphasia | 16.07 | 11.89 | 27 | 111494 | 43222 | 70773701 |
Pulmonary alveolar haemorrhage | 15.99 | 11.89 | 44 | 111477 | 10325 | 70806598 |
Thrombotic thrombocytopenic purpura | 15.87 | 11.89 | 32 | 111489 | 6145 | 70810778 |
Clostridium difficile infection | 15.84 | 11.89 | 110 | 111411 | 38706 | 70778217 |
Adenoviral haemorrhagic cystitis | 15.82 | 11.89 | 10 | 111511 | 512 | 70816411 |
Multiple organ dysfunction syndrome | 15.77 | 11.89 | 249 | 111272 | 108266 | 70708657 |
Febrile bone marrow aplasia | 15.71 | 11.89 | 48 | 111473 | 11943 | 70804980 |
Liver function test increased | 15.71 | 11.89 | 18 | 111503 | 33829 | 70783094 |
Hyperlipidaemia | 15.68 | 11.89 | 9 | 111512 | 23854 | 70793069 |
Paraproteinaemia | 15.64 | 11.89 | 9 | 111512 | 388 | 70816535 |
Pneumonia parainfluenzae viral | 15.48 | 11.89 | 8 | 111513 | 278 | 70816645 |
Hyperkalaemia | 15.47 | 11.89 | 101 | 111420 | 106490 | 70710433 |
Neuromyotonia | 15.40 | 11.89 | 6 | 111515 | 105 | 70816818 |
Venous thrombosis | 15.39 | 11.89 | 33 | 111488 | 6616 | 70810307 |
Laryngeal cancer metastatic | 15.37 | 11.89 | 5 | 111516 | 50 | 70816873 |
Engraftment syndrome | 15.32 | 11.89 | 14 | 111507 | 1250 | 70815673 |
Pneumonia respiratory syncytial viral | 15.27 | 11.89 | 15 | 111506 | 1466 | 70815457 |
Blood creatinine increased | 15.09 | 11.89 | 312 | 111209 | 142689 | 70674234 |
Nightmare | 15.07 | 11.89 | 8 | 111513 | 22148 | 70794775 |
Immunosuppression | 15.06 | 11.89 | 46 | 111475 | 11446 | 70805477 |
Panic attack | 15.03 | 11.89 | 8 | 111513 | 22111 | 70794812 |
Feeling hot | 14.95 | 11.89 | 34 | 111487 | 48636 | 70768287 |
Empyema | 14.94 | 11.89 | 24 | 111497 | 3863 | 70813060 |
Escherichia infection | 14.94 | 11.89 | 58 | 111463 | 16273 | 70800650 |
Ejection fraction decreased | 14.89 | 11.89 | 91 | 111430 | 30671 | 70786252 |
Organising pneumonia | 14.86 | 11.89 | 42 | 111479 | 10008 | 70806915 |
Parkinsonism | 14.85 | 11.89 | 3 | 111518 | 15322 | 70801601 |
Hypercholesterolaemia | 14.79 | 11.89 | 5 | 111516 | 18112 | 70798811 |
Hypocalcaemic seizure | 14.79 | 11.89 | 5 | 111516 | 57 | 70816866 |
Hypoglossal nerve paresis | 14.71 | 11.89 | 6 | 111515 | 119 | 70816804 |
Eosinophil count increased | 14.71 | 11.89 | 3 | 111518 | 15219 | 70801704 |
Infection in an immunocompromised host | 14.70 | 11.89 | 13 | 111508 | 1112 | 70815811 |
Bone erosion | 14.64 | 11.89 | 3 | 111518 | 15170 | 70801753 |
Movement disorder | 14.61 | 11.89 | 10 | 111511 | 24119 | 70792804 |
Leukopenia | 14.55 | 11.89 | 242 | 111279 | 106318 | 70710605 |
Lung disorder | 14.43 | 11.89 | 170 | 111351 | 69314 | 70747609 |
Disability | 14.38 | 11.89 | 3 | 111518 | 14980 | 70801943 |
Pneumonia bacterial | 14.34 | 11.89 | 58 | 111463 | 16583 | 70800340 |
Light chain disease | 14.34 | 11.89 | 7 | 111514 | 215 | 70816708 |
Periodontitis | 14.34 | 11.89 | 25 | 111496 | 4303 | 70812620 |
Serratia sepsis | 14.31 | 11.89 | 6 | 111515 | 128 | 70816795 |
Drug level increased | 14.27 | 11.89 | 22 | 111499 | 36447 | 70780476 |
Erysipelas | 14.22 | 11.89 | 41 | 111480 | 9883 | 70807040 |
Capillary leak syndrome | 14.17 | 11.89 | 22 | 111499 | 3440 | 70813483 |
Mouth ulceration | 14.15 | 11.89 | 20 | 111501 | 34329 | 70782594 |
Monoclonal gammopathy | 14.14 | 11.89 | 11 | 111510 | 787 | 70816136 |
Infection reactivation | 14.06 | 11.89 | 18 | 111503 | 2355 | 70814568 |
Transitional cell carcinoma | 14.03 | 11.89 | 18 | 111503 | 2359 | 70814564 |
Eosinophilic pneumonia chronic | 13.96 | 11.89 | 9 | 111512 | 477 | 70816446 |
Oesophageal adenocarcinoma | 13.84 | 11.89 | 11 | 111510 | 812 | 70816111 |
Hyperamylasaemia | 13.71 | 11.89 | 12 | 111509 | 1012 | 70815911 |
Blood triglycerides increased | 13.52 | 11.89 | 7 | 111514 | 19657 | 70797266 |
Scrotal pain | 13.44 | 11.89 | 9 | 111512 | 509 | 70816414 |
Cardiomegaly | 13.43 | 11.89 | 75 | 111446 | 24470 | 70792453 |
Cytomegalovirus enterocolitis | 13.43 | 11.89 | 14 | 111507 | 1469 | 70815454 |
Delayed engraftment | 13.39 | 11.89 | 7 | 111514 | 249 | 70816674 |
Venoocclusive liver disease | 13.30 | 11.89 | 42 | 111479 | 10636 | 70806287 |
Gastrointestinal disorder | 13.30 | 11.89 | 104 | 111417 | 105323 | 70711600 |
Cardiotoxicity | 13.30 | 11.89 | 43 | 111478 | 11027 | 70805896 |
Haemorrhagic fever | 13.20 | 11.89 | 4 | 111517 | 31 | 70816892 |
Squamous cell carcinoma of lung | 13.15 | 11.89 | 17 | 111504 | 2245 | 70814678 |
Bence Jones proteinuria | 13.08 | 11.89 | 3 | 111518 | 6 | 70816917 |
Decreased appetite | 13.04 | 11.89 | 595 | 110926 | 304185 | 70512738 |
Cholelithiasis | 13.03 | 11.89 | 35 | 111486 | 47305 | 70769618 |
Atelectasis | 12.98 | 11.89 | 84 | 111437 | 28878 | 70788045 |
Osteopenia | 12.96 | 11.89 | 5 | 111516 | 16692 | 70800231 |
Clostridium colitis | 12.95 | 11.89 | 18 | 111503 | 2548 | 70814375 |
Delusion | 12.92 | 11.89 | 7 | 111514 | 19158 | 70797765 |
Malignant neoplasm of unknown primary site | 12.84 | 11.89 | 10 | 111511 | 716 | 70816207 |
Pneumocystis jirovecii infection | 12.80 | 11.89 | 18 | 111503 | 2576 | 70814347 |
Follicle centre lymphoma, follicular grade I, II, III recurrent | 12.77 | 11.89 | 3 | 111518 | 7 | 70816916 |
Protein total decreased | 12.75 | 11.89 | 35 | 111486 | 8201 | 70808722 |
Ulcer | 12.73 | 11.89 | 13 | 111508 | 25741 | 70791182 |
Cytomegalovirus hepatitis | 12.70 | 11.89 | 10 | 111511 | 728 | 70816195 |
Psychotic disorder | 12.70 | 11.89 | 25 | 111496 | 37676 | 70779247 |
Paranoid personality disorder | 12.67 | 11.89 | 4 | 111517 | 36 | 70816887 |
Bacterial parotitis | 12.67 | 11.89 | 4 | 111517 | 36 | 70816887 |
Sciatica | 12.67 | 11.89 | 12 | 111509 | 24615 | 70792308 |
Squamous cell carcinoma | 12.66 | 11.89 | 51 | 111470 | 14553 | 70802370 |
Minimal residual disease | 12.62 | 11.89 | 8 | 111513 | 412 | 70816511 |
Insomnia | 12.59 | 11.89 | 254 | 111267 | 217552 | 70599371 |
Heart rate irregular | 12.57 | 11.89 | 17 | 111504 | 29726 | 70787197 |
Therapy cessation | 12.53 | 11.89 | 21 | 111500 | 33655 | 70783268 |
Impaired work ability | 12.51 | 11.89 | 5 | 111516 | 16335 | 70800588 |
Prinzmetal angina | 12.46 | 11.89 | 14 | 111507 | 1598 | 70815325 |
Hepatitis | 12.27 | 11.89 | 39 | 111482 | 49941 | 70766982 |
Anger | 12.25 | 11.89 | 5 | 111516 | 16127 | 70800796 |
Electrodesiccation | 12.23 | 11.89 | 3 | 111518 | 9 | 70816914 |
Pulmonary sepsis | 12.14 | 11.89 | 20 | 111501 | 3287 | 70813636 |
Encephalitis viral | 12.13 | 11.89 | 17 | 111504 | 2425 | 70814498 |
Spinal fracture | 12.11 | 11.89 | 54 | 111467 | 16113 | 70800810 |
Vertigo | 12.05 | 11.89 | 54 | 111467 | 62589 | 70754334 |
Glomerular filtration rate decreased | 12.04 | 11.89 | 9 | 111512 | 20747 | 70796176 |
Obstructive airways disorder | 12.00 | 11.89 | 14 | 111507 | 26099 | 70790824 |
Oxygen saturation decreased | 11.98 | 11.89 | 121 | 111400 | 116308 | 70700615 |
Cardio-respiratory arrest | 11.93 | 11.89 | 101 | 111420 | 100576 | 70716347 |
None
Source | Code | Description |
---|---|---|
ATC | L01XG01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Proteasome inhibitors |
FDA MoA | N0000175075 | Proteasome Inhibitors |
MeSH PA | D000970 | Antineoplastic Agents |
FDA EPC | N0000175604 | Proteasome Inhibitor |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
CHEBI has role | CHEBI:37670 | protease inhibitors |
CHEBI has role | CHEBI:52726 | proteasome inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Systemic AL amyloidosis | indication | 23132008 | |
Multiple myeloma | indication | 109989006 | DOID:9538 |
Mantle cell lymphoma | indication | 443487006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Interstitial pneumonia | contraindication | 64667001 | |
Adult respiratory distress syndrome | contraindication | 67782005 | DOID:11394 |
Pulmonary hypertension | contraindication | 70995007 | DOID:6432 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Intestinal obstruction | contraindication | 81060008 | DOID:8437 |
Prolonged QT interval | contraindication | 111975006 | |
Pneumonia | contraindication | 233604007 | DOID:552 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Breastfeeding (mother) | contraindication | 413712001 | |
Posterior reversible encephalopathy syndrome | contraindication | 450886002 | |
Chemotherapy-Induced Hyperuricemia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.39 | acidic |
pKa2 | 12.09 | acidic |
pKa3 | 13.65 | acidic |
pKa4 | 2.9 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
3.5MG/VIAL | VELCADE | TAKEDA PHARMS USA | N021602 | May 13, 2003 | RX | INJECTABLE | INTRAVENOUS, SUBCUTANEOUS | April 8, 2022 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Proteasome subunit beta type-5 | Enzyme | INHIBITOR | Ki | 9.26 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-8 | Enzyme | INHIBITOR | IC50 | 8.09 | CHEMBL | CHEMBL | |||
Proteasome subunit alpha type-1 | Enzyme | INHIBITOR | Ki | 9.21 | WOMBAT-PK | CHEMBL | |||
Proteasome subunit beta type-1 | Enzyme | INHIBITOR | IC50 | 7.28 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-2 | Enzyme | INHIBITOR | IC50 | 6.23 | CHEMBL | CHEMBL | |||
Prothrombin | Enzyme | Ki | 4.89 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.16 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.17 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | Ki | 4.75 | WOMBAT-PK | |||||
26S proteasome non-ATPase regulatory subunit 1 | Cytosolic other | Ki | 7.75 | WOMBAT-PK | |||||
Histone deacetylase 2 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
Histone deacetylase 1 | Enzyme | IC50 | 6.21 | CHEMBL | |||||
Histone deacetylase 3 | Enzyme | IC50 | 5.93 | CHEMBL | |||||
Histone deacetylase 6 | Enzyme | IC50 | 4.16 | CHEMBL | |||||
Neutrophil elastase | Enzyme | Ki | 5.64 | CHEMBL | |||||
Carbonic anhydrase 3 | Enzyme | Ki | 5.34 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 5.36 | CHEMBL | |||||
Histone deacetylase 8 | Enzyme | IC50 | 7.14 | CHEMBL | |||||
Cathepsin G | Enzyme | Ki | 6.20 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.48 | CHEMBL | |||||
Chymase | Enzyme | IC50 | 5.92 | CHEMBL | |||||
Chymotrypsinogen B | Enzyme | Ki | 6.49 | CHEMBL | |||||
Lysosomal protective protein | Enzyme | IC50 | 5.04 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 5.07 | CHEMBL | |||||
PH and SEC7 domain-containing protein 1 | Unclassified | Ki | 7.75 | WOMBAT-PK | |||||
Nuclear factor NF-kappa-B complex | Transcription factor | IC50 | 8.01 | CHEMBL | |||||
Proteasome subunit beta type-9 | Enzyme | IC50 | 8.52 | CHEMBL | |||||
Proteasome subunit beta type-10 | Enzyme | IC50 | 6.03 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 5.94 | CHEMBL | |||||
Carbonic anhydrase 1 | Enzyme | Ki | 5.89 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 5.19 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 5.47 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 5.23 | CHEMBL | |||||
Carbonic anhydrase 15 | Enzyme | Ki | 5.57 | CHEMBL | |||||
Beta-carbonic anhydrase 1 | Enzyme | Ki | 5.14 | CHEMBL | |||||
Alpha-chymotrypsin | Enzyme | Ki | 5.62 | CHEMBL | |||||
Proteasome subunit beta | Enzyme | IC50 | 7.51 | IUPHAR | |||||
Proteasome subunit beta type-8 | Enzyme | IC50 | 7.78 | CHEMBL | |||||
ATP-dependent Clp protease proteolytic subunit | Enzyme | IC50 | 5.28 | CHEMBL |
ID | Source |
---|---|
4021393 | VUID |
N0000148811 | NUI |
D03150 | KEGG_DRUG |
356733 | RXNORM |
4021393 | VANDF |
C1176309 | UMLSCUI |
CHEBI:52717 | CHEBI |
BO2 | PDB_CHEM_ID |
CHEMBL325041 | ChEMBL_ID |
DB00188 | DRUGBANK_ID |
D000069286 | MESH_DESCRIPTOR_UI |
387447 | PUBCHEM_CID |
6391 | IUPHAR_LIGAND_ID |
8331 | INN_ID |
69G8BD63PP | UNII |
17263 | MMSL |
233935 | MMSL |
46756 | MMSL |
d04871 | MMSL |
009985 | NDDF |
398907002 | SNOMEDCT_US |
407097007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9098 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1700 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 33 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1703 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2.50 mg | INTRAVENOUS | NDA | 33 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1704 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 33 sections |
bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3258 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 27 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-244 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-426 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 30 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-865 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 26 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-484 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51817-586 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 32 sections |
BORTEZOMIB | Human Prescription Drug Label | 1 | 55150-337 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6050 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-821 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 30 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67184-0530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-534 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-540 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-541 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 26 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70511-161 | INJECTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70511-162 | INJECTION | 2.50 mg | INTRAVENOUS | NDA | 31 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-1411 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1708 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 2 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70860-225 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71288-118 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
Bortezomib | Human Prescription Drug Label | 1 | 72205-183 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 26 sections |