Stem definition | Drug id | CAS RN |
---|---|---|
proteasome inhibitors | 391 | 179324-69-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.30 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.08 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.17 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 14, 2019 | EMA | FRESENIUS KABI DEUTSCHLAND GMBH | |
Aug. 22, 2019 | PMDA | Janssen Pharmaceutical K.K. | |
May 13, 2003 | FDA | MILLENNIUM PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2319.73 | 13.63 | 1430 | 58003 | 95327 | 50450364 |
Plasma cell myeloma | 1302.98 | 13.63 | 666 | 58767 | 30656 | 50515035 |
Thrombocytopenia | 538.84 | 13.63 | 705 | 58728 | 126968 | 50418723 |
Plasma cell myeloma recurrent | 524.95 | 13.63 | 173 | 59260 | 2485 | 50543206 |
Platelet count decreased | 402.77 | 13.63 | 542 | 58891 | 100184 | 50445507 |
Diarrhoea | 390.34 | 13.63 | 1539 | 57894 | 586937 | 49958754 |
Disease progression | 363.79 | 13.63 | 503 | 58930 | 95363 | 50450328 |
Plasmacytoma | 315.13 | 13.63 | 115 | 59318 | 2270 | 50543421 |
Constipation | 262.10 | 13.63 | 634 | 58799 | 185074 | 50360617 |
Pneumonia | 256.40 | 13.63 | 998 | 58435 | 377403 | 50168288 |
Polyneuropathy | 243.83 | 13.63 | 161 | 59272 | 11970 | 50533721 |
Neutropenia | 230.27 | 13.63 | 525 | 58908 | 147440 | 50398251 |
White blood cell count decreased | 218.05 | 13.63 | 446 | 58987 | 116276 | 50429415 |
Rheumatoid arthritis | 214.03 | 13.63 | 5 | 59428 | 202545 | 50343146 |
Plasma cell leukaemia | 188.17 | 13.63 | 63 | 59370 | 952 | 50544739 |
Pancytopenia | 176.04 | 13.63 | 337 | 59096 | 83693 | 50461998 |
Maternal exposure during pregnancy | 168.54 | 13.63 | 4 | 59429 | 159774 | 50385917 |
Drug hypersensitivity | 158.38 | 13.63 | 49 | 59384 | 250961 | 50294730 |
Contraindicated product administered | 156.08 | 13.63 | 4 | 59429 | 148954 | 50396737 |
Full blood count decreased | 152.02 | 13.63 | 158 | 59275 | 22188 | 50523503 |
Tumour lysis syndrome | 143.11 | 13.63 | 96 | 59337 | 7325 | 50538366 |
Headache | 142.73 | 13.63 | 235 | 59198 | 506300 | 50039391 |
Arthralgia | 142.70 | 13.63 | 184 | 59249 | 438518 | 50107173 |
Sepsis | 139.65 | 13.63 | 407 | 59026 | 132518 | 50413173 |
Exposure during pregnancy | 127.71 | 13.63 | 3 | 59430 | 121012 | 50424679 |
Drug ineffective | 125.14 | 13.63 | 518 | 58915 | 818815 | 49726876 |
Laboratory test abnormal | 119.74 | 13.63 | 142 | 59291 | 23066 | 50522625 |
Unevaluable event | 119.72 | 13.63 | 203 | 59230 | 45863 | 50499828 |
Anaemia | 119.51 | 13.63 | 599 | 58834 | 251857 | 50293834 |
Peripheral sensory neuropathy | 114.63 | 13.63 | 80 | 59353 | 6511 | 50539180 |
Glossodynia | 114.37 | 13.63 | 5 | 59428 | 115564 | 50430127 |
Febrile neutropenia | 113.23 | 13.63 | 310 | 59123 | 97357 | 50448334 |
Dehydration | 108.36 | 13.63 | 409 | 59024 | 152040 | 50393651 |
Neutrophil count decreased | 105.57 | 13.63 | 192 | 59241 | 45834 | 50499857 |
Deep vein thrombosis | 104.98 | 13.63 | 252 | 59181 | 73052 | 50472639 |
Pain | 104.56 | 13.63 | 341 | 59092 | 578562 | 49967129 |
Cardiac amyloidosis | 99.37 | 13.63 | 36 | 59397 | 695 | 50544996 |
Product use in unapproved indication | 96.15 | 13.63 | 327 | 59106 | 115492 | 50430199 |
Therapeutic product effect decreased | 92.36 | 13.63 | 23 | 59410 | 136027 | 50409664 |
Septic shock | 91.11 | 13.63 | 205 | 59228 | 56970 | 50488721 |
Swelling | 88.67 | 13.63 | 64 | 59369 | 200808 | 50344883 |
Chalazion | 86.56 | 13.63 | 27 | 59406 | 321 | 50545370 |
Amyloidosis | 85.57 | 13.63 | 35 | 59398 | 948 | 50544743 |
Posterior reversible encephalopathy syndrome | 84.81 | 13.63 | 96 | 59337 | 14832 | 50530859 |
Condition aggravated | 83.26 | 13.63 | 138 | 59295 | 296920 | 50248771 |
Alopecia | 81.33 | 13.63 | 101 | 59332 | 244946 | 50300745 |
Hordeolum | 80.56 | 13.63 | 44 | 59389 | 2309 | 50543382 |
Herpes zoster | 80.34 | 13.63 | 223 | 59210 | 70563 | 50475128 |
Cytopenia | 80.26 | 13.63 | 73 | 59360 | 8702 | 50536989 |
Light chain analysis increased | 78.55 | 13.63 | 34 | 59399 | 1064 | 50544627 |
Arthropathy | 78.32 | 13.63 | 44 | 59389 | 157862 | 50387829 |
Discomfort | 78.21 | 13.63 | 16 | 59417 | 108364 | 50437327 |
Renal failure | 77.30 | 13.63 | 288 | 59145 | 106345 | 50439346 |
Off label use | 77.04 | 13.63 | 873 | 58560 | 473553 | 50072138 |
Drug interaction | 76.49 | 13.63 | 73 | 59360 | 199548 | 50346143 |
Abdominal discomfort | 76.31 | 13.63 | 96 | 59337 | 231545 | 50314146 |
Musculoskeletal stiffness | 75.86 | 13.63 | 28 | 59405 | 128453 | 50417238 |
Wound | 73.53 | 13.63 | 17 | 59416 | 105777 | 50439914 |
Pericarditis | 70.07 | 13.63 | 6 | 59427 | 78683 | 50467008 |
Overdose | 69.36 | 13.63 | 16 | 59417 | 99711 | 50445980 |
Orthostatic hypotension | 68.88 | 13.63 | 124 | 59309 | 29357 | 50516334 |
Hyperviscosity syndrome | 67.98 | 13.63 | 19 | 59414 | 149 | 50545542 |
Joint swelling | 67.73 | 13.63 | 115 | 59318 | 245171 | 50300520 |
Myelodysplastic syndrome | 67.41 | 13.63 | 86 | 59347 | 15046 | 50530645 |
Treatment failure | 65.91 | 13.63 | 40 | 59393 | 137597 | 50408094 |
Thrombosis | 63.44 | 13.63 | 176 | 59257 | 55657 | 50490034 |
Monoclonal immunoglobulin present | 63.23 | 13.63 | 26 | 59407 | 714 | 50544977 |
Protein total increased | 62.30 | 13.63 | 38 | 59395 | 2458 | 50543233 |
Injection site pain | 60.97 | 13.63 | 27 | 59406 | 110997 | 50434694 |
Haemoglobin decreased | 60.84 | 13.63 | 303 | 59130 | 126913 | 50418778 |
Atrial fibrillation | 60.24 | 13.63 | 258 | 59175 | 101487 | 50444204 |
Therapy partial responder | 58.65 | 13.63 | 54 | 59379 | 6537 | 50539154 |
Stem cell transplant | 56.58 | 13.63 | 31 | 59402 | 1637 | 50544054 |
Hepatic enzyme increased | 54.06 | 13.63 | 49 | 59384 | 137331 | 50408360 |
Pathological fracture | 53.46 | 13.63 | 55 | 59378 | 7627 | 50538064 |
Cytomegalovirus infection reactivation | 53.05 | 13.63 | 35 | 59398 | 2596 | 50543095 |
Coombs indirect test positive | 52.39 | 13.63 | 12 | 59421 | 36 | 50545655 |
Autonomic neuropathy | 52.32 | 13.63 | 25 | 59408 | 988 | 50544703 |
Mobility decreased | 51.44 | 13.63 | 15 | 59418 | 79933 | 50465758 |
Haematotoxicity | 50.44 | 13.63 | 54 | 59379 | 7841 | 50537850 |
Hypocalcaemia | 48.23 | 13.63 | 101 | 59332 | 26715 | 50518976 |
Hypersensitivity | 48.12 | 13.63 | 114 | 59319 | 215047 | 50330644 |
Pyrexia | 48.01 | 13.63 | 668 | 58765 | 379535 | 50166156 |
Wrong technique in product usage process | 47.38 | 13.63 | 5 | 59428 | 55505 | 50490186 |
Cytomegalovirus infection | 46.44 | 13.63 | 79 | 59354 | 17883 | 50527808 |
Ileus paralytic | 45.73 | 13.63 | 38 | 59395 | 4012 | 50541679 |
Ageusia | 45.67 | 13.63 | 62 | 59371 | 11521 | 50534170 |
Bone marrow failure | 43.93 | 13.63 | 99 | 59334 | 27525 | 50518166 |
Bone pain | 43.31 | 13.63 | 138 | 59295 | 47091 | 50498600 |
Hypercalcaemia | 43.23 | 13.63 | 89 | 59344 | 23263 | 50522428 |
Peripheral sensorimotor neuropathy | 41.55 | 13.63 | 23 | 59410 | 1239 | 50544452 |
Fibromyalgia | 41.24 | 13.63 | 3 | 59430 | 44975 | 50500716 |
Helicobacter infection | 41.11 | 13.63 | 5 | 59428 | 49697 | 50495994 |
Suicide attempt | 40.89 | 13.63 | 6 | 59427 | 51726 | 50493965 |
Malignant neoplasm progression | 40.49 | 13.63 | 173 | 59260 | 67951 | 50477740 |
Mesenteric abscess | 39.85 | 13.63 | 11 | 59422 | 82 | 50545609 |
Fatigue | 39.80 | 13.63 | 1099 | 58334 | 706502 | 49839189 |
Body dysmorphic disorder | 39.60 | 13.63 | 14 | 59419 | 251 | 50545440 |
Oedema peripheral | 39.58 | 13.63 | 319 | 59114 | 157642 | 50388049 |
Peripheral motor neuropathy | 38.86 | 13.63 | 23 | 59410 | 1408 | 50544283 |
Syncope | 38.21 | 13.63 | 229 | 59204 | 102773 | 50442918 |
Endocarditis bacterial | 37.93 | 13.63 | 17 | 59416 | 579 | 50545112 |
Blister | 37.93 | 13.63 | 27 | 59406 | 85391 | 50460300 |
Hepatitis B reactivation | 37.86 | 13.63 | 26 | 59407 | 2061 | 50543630 |
Pneumonia fungal | 37.68 | 13.63 | 35 | 59398 | 4285 | 50541406 |
Electrolyte imbalance | 37.31 | 13.63 | 70 | 59363 | 17099 | 50528592 |
Large intestinal ulcer perforation | 37.15 | 13.63 | 10 | 59423 | 67 | 50545624 |
Drug abuse | 37.10 | 13.63 | 12 | 59421 | 59834 | 50485857 |
Inappropriate antidiuretic hormone secretion | 36.91 | 13.63 | 60 | 59373 | 13083 | 50532608 |
Blood potassium decreased | 36.69 | 13.63 | 111 | 59322 | 36834 | 50508857 |
Colitis | 36.63 | 13.63 | 114 | 59319 | 38415 | 50507276 |
Blood pressure increased | 36.16 | 13.63 | 63 | 59370 | 133069 | 50412622 |
Pleural effusion | 36.11 | 13.63 | 190 | 59243 | 81264 | 50464427 |
Asthenia | 36.05 | 13.63 | 550 | 58883 | 318492 | 50227199 |
Migraine | 35.85 | 13.63 | 22 | 59411 | 75258 | 50470433 |
Therapy non-responder | 35.44 | 13.63 | 136 | 59297 | 50886 | 50494805 |
Hypoaesthesia | 35.20 | 13.63 | 263 | 59170 | 126994 | 50418697 |
Nasal abscess | 34.87 | 13.63 | 11 | 59422 | 136 | 50545555 |
Crossmatch incompatible | 33.35 | 13.63 | 8 | 59425 | 31 | 50545660 |
Anxiety | 33.00 | 13.63 | 103 | 59330 | 177503 | 50368188 |
Irritable bowel syndrome | 32.45 | 13.63 | 10 | 59423 | 51431 | 50494260 |
Gastrointestinal fungal infection | 32.01 | 13.63 | 12 | 59421 | 256 | 50545435 |
Depression | 31.40 | 13.63 | 95 | 59338 | 165328 | 50380363 |
Osteolysis | 30.99 | 13.63 | 25 | 59408 | 2532 | 50543159 |
Taste disorder | 30.48 | 13.63 | 43 | 59390 | 8281 | 50537410 |
Renal amyloidosis | 30.31 | 13.63 | 10 | 59423 | 144 | 50545547 |
Disturbance in social behaviour | 30.30 | 13.63 | 26 | 59407 | 2868 | 50542823 |
Cardiac failure | 30.10 | 13.63 | 172 | 59261 | 75868 | 50469823 |
Rash | 29.95 | 13.63 | 698 | 58735 | 436773 | 50108918 |
Blood stem cell harvest failure | 29.54 | 13.63 | 8 | 59425 | 55 | 50545636 |
Primary amyloidosis | 29.41 | 13.63 | 7 | 59426 | 26 | 50545665 |
Large intestine perforation | 29.37 | 13.63 | 40 | 59393 | 7454 | 50538237 |
Target skin lesion | 29.01 | 13.63 | 9 | 59424 | 105 | 50545586 |
Morganella infection | 28.89 | 13.63 | 14 | 59419 | 571 | 50545120 |
Osteoarthritis | 28.77 | 13.63 | 23 | 59410 | 68583 | 50477108 |
Blood pressure fluctuation | 28.67 | 13.63 | 4 | 59429 | 35819 | 50509872 |
Renal impairment | 28.55 | 13.63 | 169 | 59264 | 75492 | 50470199 |
Hypokalaemia | 28.50 | 13.63 | 189 | 59244 | 87803 | 50457888 |
Arthritis | 28.45 | 13.63 | 36 | 59397 | 86685 | 50459006 |
Clostridium bacteraemia | 28.20 | 13.63 | 10 | 59423 | 181 | 50545510 |
Guillain-Barre syndrome | 28.09 | 13.63 | 27 | 59406 | 3450 | 50542241 |
Suicidal ideation | 28.06 | 13.63 | 15 | 59418 | 55370 | 50490321 |
Acute lymphocytic leukaemia | 27.35 | 13.63 | 22 | 59411 | 2219 | 50543472 |
COVID-19 | 27.34 | 13.63 | 118 | 59315 | 46544 | 50499147 |
Anaphylactic reaction | 26.86 | 13.63 | 15 | 59418 | 54040 | 50491651 |
Refractory cytopenia with multilineage dysplasia | 26.70 | 13.63 | 9 | 59424 | 139 | 50545552 |
Blood lactate dehydrogenase increased | 26.64 | 13.63 | 66 | 59367 | 19496 | 50526195 |
Inappropriate schedule of product administration | 26.63 | 13.63 | 27 | 59406 | 71804 | 50473887 |
Spinal cord compression | 26.62 | 13.63 | 27 | 59406 | 3682 | 50542009 |
Sinus polyp | 26.59 | 13.63 | 11 | 59422 | 307 | 50545384 |
Drug intolerance | 26.47 | 13.63 | 150 | 59283 | 218954 | 50326737 |
Loss of personal independence in daily activities | 26.35 | 13.63 | 26 | 59407 | 70024 | 50475667 |
Bronchiolitis | 26.18 | 13.63 | 22 | 59411 | 2359 | 50543332 |
Adverse drug reaction | 25.99 | 13.63 | 131 | 59302 | 55091 | 50490600 |
Adenoviral haemorrhagic cystitis | 25.85 | 13.63 | 9 | 59424 | 154 | 50545537 |
Hypertension | 25.83 | 13.63 | 144 | 59289 | 211059 | 50334632 |
Graft versus host disease | 25.83 | 13.63 | 34 | 59399 | 6132 | 50539559 |
Joint ankylosis | 25.36 | 13.63 | 14 | 59419 | 750 | 50544941 |
Osteonecrosis of jaw | 25.35 | 13.63 | 90 | 59343 | 32436 | 50513255 |
Joint stiffness | 25.18 | 13.63 | 3 | 59430 | 30305 | 50515386 |
Death | 25.03 | 13.63 | 528 | 58905 | 324851 | 50220840 |
Hypophosphataemia | 24.43 | 13.63 | 39 | 59394 | 8375 | 50537316 |
Pseudomonal sepsis | 24.27 | 13.63 | 20 | 59413 | 2087 | 50543604 |
Cardiac failure congestive | 24.24 | 13.63 | 176 | 59257 | 84206 | 50461485 |
Blood pressure systolic increased | 24.02 | 13.63 | 6 | 59427 | 35443 | 50510248 |
Bone lesion | 24.00 | 13.63 | 30 | 59403 | 5140 | 50540551 |
Neuralgia | 23.92 | 13.63 | 68 | 59365 | 21795 | 50523896 |
Impaired healing | 23.91 | 13.63 | 28 | 59405 | 69758 | 50475933 |
Blood cholesterol increased | 23.80 | 13.63 | 18 | 59415 | 55197 | 50490494 |
Palpitations | 23.64 | 13.63 | 47 | 59386 | 94459 | 50451232 |
Heart rate increased | 23.38 | 13.63 | 34 | 59399 | 77216 | 50468475 |
Toxic skin eruption | 23.37 | 13.63 | 45 | 59388 | 11206 | 50534485 |
Pneumonia pneumococcal | 23.37 | 13.63 | 18 | 59415 | 1705 | 50543986 |
Cerebellar haemangioma | 23.36 | 13.63 | 7 | 59426 | 72 | 50545619 |
Intraductal proliferative breast lesion | 22.90 | 13.63 | 21 | 59412 | 2529 | 50543162 |
Flushing | 22.84 | 13.63 | 27 | 59406 | 66988 | 50478703 |
Compression fracture | 22.64 | 13.63 | 31 | 59402 | 5806 | 50539885 |
Stress | 22.59 | 13.63 | 18 | 59415 | 53775 | 50491916 |
Neurotoxicity | 22.52 | 13.63 | 52 | 59381 | 14688 | 50531003 |
Salmonella sepsis | 22.45 | 13.63 | 9 | 59424 | 231 | 50545460 |
Injury | 22.33 | 13.63 | 15 | 59418 | 48910 | 50496781 |
Pregnancy | 22.10 | 13.63 | 4 | 59429 | 29573 | 50516118 |
Failure to thrive | 22.04 | 13.63 | 32 | 59401 | 6326 | 50539365 |
Hyperproteinaemia | 21.73 | 13.63 | 7 | 59426 | 93 | 50545598 |
Injection site swelling | 21.63 | 13.63 | 11 | 59422 | 41762 | 50503929 |
Mucosal inflammation | 21.62 | 13.63 | 99 | 59334 | 40043 | 50505648 |
Nasal congestion | 21.60 | 13.63 | 17 | 59416 | 51103 | 50494588 |
Seasonal allergy | 21.57 | 13.63 | 51 | 59382 | 14625 | 50531066 |
Varicella zoster virus infection | 21.39 | 13.63 | 20 | 59413 | 2469 | 50543222 |
Peritonitis viral | 21.36 | 13.63 | 6 | 59427 | 48 | 50545643 |
Product quality issue | 21.35 | 13.63 | 5 | 59428 | 30853 | 50514838 |
Acute kidney injury | 21.22 | 13.63 | 381 | 59052 | 227677 | 50318014 |
Enterococcal sepsis | 21.06 | 13.63 | 15 | 59418 | 1260 | 50544431 |
Hypothyroidism | 20.87 | 13.63 | 7 | 59426 | 34118 | 50511573 |
Malaise | 20.62 | 13.63 | 274 | 59159 | 335258 | 50210433 |
Disease recurrence | 20.56 | 13.63 | 61 | 59372 | 20020 | 50525671 |
Hypotension | 20.04 | 13.63 | 388 | 59045 | 235081 | 50310610 |
Hypoalbuminaemia | 19.94 | 13.63 | 39 | 59394 | 9821 | 50535870 |
5q minus syndrome | 19.86 | 13.63 | 8 | 59425 | 208 | 50545483 |
Cardiotoxicity | 19.62 | 13.63 | 32 | 59401 | 6995 | 50538696 |
Gait disturbance | 19.59 | 13.63 | 100 | 59333 | 149905 | 50395786 |
Ileus | 19.47 | 13.63 | 46 | 59387 | 13183 | 50532508 |
Thrombotic microangiopathy | 19.29 | 13.63 | 36 | 59397 | 8755 | 50536936 |
Serotonin syndrome | 19.22 | 13.63 | 3 | 59430 | 24710 | 50520981 |
Back pain | 19.21 | 13.63 | 364 | 59069 | 219666 | 50326025 |
Myalgia | 19.14 | 13.63 | 78 | 59355 | 124241 | 50421450 |
Meningitis listeria | 19.13 | 13.63 | 10 | 59423 | 480 | 50545211 |
Transplant | 19.11 | 13.63 | 11 | 59422 | 639 | 50545052 |
Human chorionic gonadotropin increased | 19.03 | 13.63 | 14 | 59419 | 1237 | 50544454 |
Contusion | 18.81 | 13.63 | 68 | 59365 | 112115 | 50433576 |
Blood creatine phosphokinase increased | 18.79 | 13.63 | 4 | 59429 | 26363 | 50519328 |
Toxicity to various agents | 18.71 | 13.63 | 352 | 59081 | 212147 | 50333544 |
VIth nerve paresis | 18.68 | 13.63 | 6 | 59427 | 79 | 50545612 |
Mucosal erosion | 18.68 | 13.63 | 14 | 59419 | 1273 | 50544418 |
Ill-defined disorder | 18.65 | 13.63 | 22 | 59411 | 54632 | 50491059 |
Injection site bruising | 18.56 | 13.63 | 10 | 59423 | 36758 | 50508933 |
Sleep disorder | 18.55 | 13.63 | 24 | 59409 | 57259 | 50488432 |
Paraesthesia | 18.36 | 13.63 | 219 | 59214 | 120024 | 50425667 |
Acute myopia | 18.27 | 13.63 | 6 | 59427 | 85 | 50545606 |
Plasma cells decreased | 18.26 | 13.63 | 5 | 59428 | 36 | 50545655 |
Full blood count increased | 18.26 | 13.63 | 12 | 59421 | 884 | 50544807 |
Pulmonary embolism | 18.15 | 13.63 | 191 | 59242 | 101513 | 50444178 |
Wheezing | 18.11 | 13.63 | 28 | 59405 | 62019 | 50483672 |
Meningitis cryptococcal | 17.84 | 13.63 | 13 | 59420 | 1132 | 50544559 |
Light chain analysis | 17.72 | 13.63 | 4 | 59429 | 11 | 50545680 |
Spinal fracture | 17.59 | 13.63 | 49 | 59384 | 15524 | 50530167 |
Diarrhoea haemorrhagic | 17.56 | 13.63 | 32 | 59401 | 7643 | 50538048 |
Fungal oesophagitis | 17.52 | 13.63 | 10 | 59423 | 572 | 50545119 |
Sedation | 17.50 | 13.63 | 7 | 59426 | 30603 | 50515088 |
Hypogammaglobulinaemia | 17.36 | 13.63 | 27 | 59406 | 5672 | 50540019 |
Monoclonal immunoglobulin increased | 17.32 | 13.63 | 6 | 59427 | 101 | 50545590 |
Nocardiosis | 17.26 | 13.63 | 15 | 59418 | 1683 | 50544008 |
Infection reactivation | 17.21 | 13.63 | 12 | 59421 | 975 | 50544716 |
Somnolence | 17.17 | 13.63 | 109 | 59324 | 154876 | 50390815 |
Tooth disorder | 17.16 | 13.63 | 65 | 59368 | 24163 | 50521528 |
Cardiac failure acute | 17.14 | 13.63 | 33 | 59400 | 8217 | 50537474 |
Pneumonia influenzal | 17.06 | 13.63 | 14 | 59419 | 1453 | 50544238 |
Hypoglossal nerve paresis | 17.05 | 13.63 | 6 | 59427 | 106 | 50545585 |
Incorrect dose administered | 17.05 | 13.63 | 19 | 59414 | 48395 | 50497296 |
Bacteraemia | 16.88 | 13.63 | 46 | 59387 | 14387 | 50531304 |
Infection in an immunocompromised host | 16.82 | 13.63 | 9 | 59424 | 453 | 50545238 |
Sensory level abnormal | 16.70 | 13.63 | 6 | 59427 | 113 | 50545578 |
Acute myeloid leukaemia | 16.60 | 13.63 | 47 | 59386 | 15027 | 50530664 |
Multiple allergies | 16.54 | 13.63 | 33 | 59400 | 8430 | 50537261 |
Spinal compression fracture | 16.50 | 13.63 | 42 | 59391 | 12614 | 50533077 |
Osteonecrosis | 16.44 | 13.63 | 61 | 59372 | 22456 | 50523235 |
Myeloma cast nephropathy | 16.41 | 13.63 | 6 | 59427 | 119 | 50545572 |
Pseudomyopia | 16.38 | 13.63 | 5 | 59428 | 55 | 50545636 |
Pulmonary oedema | 16.38 | 13.63 | 106 | 59327 | 48832 | 50496859 |
Sleep apnoea syndrome | 16.25 | 13.63 | 4 | 59429 | 23864 | 50521827 |
Duodenal stenosis | 16.22 | 13.63 | 9 | 59424 | 487 | 50545204 |
Oncologic complication | 16.09 | 13.63 | 6 | 59427 | 126 | 50545565 |
Hyperamylasaemia | 16.03 | 13.63 | 8 | 59425 | 348 | 50545343 |
Human herpesvirus 8 infection | 16.03 | 13.63 | 7 | 59426 | 224 | 50545467 |
Chronic graft versus host disease in skin | 16.02 | 13.63 | 10 | 59423 | 674 | 50545017 |
Skin exfoliation | 16.00 | 13.63 | 80 | 59353 | 33532 | 50512159 |
Superficial spreading melanoma stage unspecified | 15.96 | 13.63 | 6 | 59427 | 129 | 50545562 |
Respiratory tract infection | 15.80 | 13.63 | 77 | 59356 | 31940 | 50513751 |
Blepharitis | 15.79 | 13.63 | 16 | 59417 | 2179 | 50543512 |
Injection site haemorrhage | 15.71 | 13.63 | 3 | 59430 | 21343 | 50524348 |
Rash pruritic | 15.62 | 13.63 | 103 | 59330 | 47743 | 50497948 |
Pain in extremity | 15.61 | 13.63 | 226 | 59207 | 272639 | 50273052 |
Drug withdrawal syndrome | 15.59 | 13.63 | 5 | 59428 | 25076 | 50520615 |
Performance status decreased | 15.57 | 13.63 | 19 | 59414 | 3176 | 50542515 |
Clostridium difficile colitis | 15.49 | 13.63 | 51 | 59382 | 17691 | 50528000 |
Blood immunoglobulin A increased | 15.48 | 13.63 | 8 | 59425 | 375 | 50545316 |
Aggression | 15.47 | 13.63 | 3 | 59430 | 21113 | 50524578 |
Decreased appetite | 15.40 | 13.63 | 326 | 59107 | 200597 | 50345094 |
Osteoporosis | 15.38 | 13.63 | 18 | 59415 | 44861 | 50500830 |
Coma | 15.36 | 13.63 | 27 | 59406 | 56852 | 50488839 |
Rhabdomyolysis | 15.24 | 13.63 | 14 | 59419 | 39013 | 50506678 |
Clavicle fracture | 15.18 | 13.63 | 18 | 59415 | 2921 | 50542770 |
Dysarthria | 15.11 | 13.63 | 13 | 59420 | 37390 | 50508301 |
JC virus CSF test positive | 15.10 | 13.63 | 4 | 59429 | 25 | 50545666 |
Sinusitis | 15.03 | 13.63 | 128 | 59305 | 170430 | 50375261 |
Haemorrhoidal haemorrhage | 15.02 | 13.63 | 20 | 59413 | 3647 | 50542044 |
Staphylococcal bacteraemia | 14.70 | 13.63 | 23 | 59410 | 4854 | 50540837 |
Atelectasis | 14.62 | 13.63 | 51 | 59382 | 18219 | 50527472 |
Infusion related reaction | 14.61 | 13.63 | 128 | 59305 | 169429 | 50376262 |
Underdose | 14.60 | 13.63 | 3 | 59430 | 20275 | 50525416 |
Therapy interrupted | 14.48 | 13.63 | 3 | 59430 | 20149 | 50525542 |
Hepatitis B | 14.35 | 13.63 | 19 | 59414 | 3447 | 50542244 |
Paraproteinaemia | 14.32 | 13.63 | 6 | 59427 | 173 | 50545518 |
Weight increased | 14.22 | 13.63 | 160 | 59273 | 201731 | 50343960 |
Lactic acidosis | 14.21 | 13.63 | 11 | 59422 | 33344 | 50512347 |
Herpes zoster reactivation | 14.13 | 13.63 | 4 | 59429 | 33 | 50545658 |
Cough | 14.09 | 13.63 | 199 | 59234 | 241065 | 50304626 |
Plasmablastic lymphoma | 13.91 | 13.63 | 6 | 59427 | 186 | 50545505 |
Respiratory failure | 13.88 | 13.63 | 166 | 59267 | 91015 | 50454676 |
Pneumonia cytomegaloviral | 13.69 | 13.63 | 14 | 59419 | 1927 | 50543764 |
Cryptococcosis | 13.65 | 13.63 | 10 | 59423 | 878 | 50544813 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2398.76 | 12.99 | 1690 | 68143 | 69337 | 29435357 |
Plasma cell myeloma | 1272.29 | 12.99 | 893 | 68940 | 36222 | 29468472 |
Plasma cell myeloma recurrent | 555.39 | 12.99 | 237 | 69596 | 3446 | 29501248 |
Thrombocytopenia | 434.38 | 12.99 | 972 | 68861 | 133851 | 29370843 |
Polyneuropathy | 433.35 | 12.99 | 300 | 69533 | 11852 | 29492842 |
Platelet count decreased | 393.77 | 12.99 | 804 | 69029 | 103868 | 29400826 |
Disease progression | 318.27 | 12.99 | 638 | 69195 | 81278 | 29423416 |
Pneumonia | 282.93 | 12.99 | 1493 | 68340 | 318679 | 29186015 |
Plasmacytoma | 275.76 | 12.99 | 140 | 69693 | 3075 | 29501619 |
Drug interaction | 260.72 | 12.99 | 72 | 69761 | 197313 | 29307381 |
Unevaluable event | 224.53 | 12.99 | 313 | 69520 | 29538 | 29475156 |
Completed suicide | 197.62 | 12.99 | 3 | 69830 | 90243 | 29414451 |
Drug abuse | 173.45 | 12.99 | 3 | 69830 | 79880 | 29424814 |
Tumour lysis syndrome | 166.35 | 12.99 | 184 | 69649 | 13700 | 29490994 |
Plasma cell leukaemia | 163.61 | 12.99 | 64 | 69769 | 733 | 29503961 |
Orthostatic hypotension | 162.31 | 12.99 | 232 | 69601 | 22397 | 29482297 |
Herpes zoster | 142.38 | 12.99 | 255 | 69578 | 29797 | 29474897 |
Constipation | 139.33 | 12.99 | 586 | 69247 | 113574 | 29391120 |
White blood cell count decreased | 134.69 | 12.99 | 468 | 69365 | 82894 | 29421800 |
Diarrhoea | 126.35 | 12.99 | 1268 | 68565 | 331430 | 29173264 |
Peripheral sensory neuropathy | 122.49 | 12.99 | 106 | 69727 | 5833 | 29498861 |
Fatigue | 120.49 | 12.99 | 1208 | 68625 | 315613 | 29189081 |
Overdose | 111.16 | 12.99 | 26 | 69807 | 79793 | 29424901 |
Deep vein thrombosis | 106.70 | 12.99 | 338 | 69495 | 57061 | 29447633 |
Autonomic neuropathy | 102.97 | 12.99 | 47 | 69786 | 808 | 29503886 |
Neutropenia | 97.43 | 12.99 | 587 | 69246 | 131124 | 29373570 |
Product use issue | 95.67 | 12.99 | 303 | 69530 | 51141 | 29453553 |
Hypercalcaemia | 91.74 | 12.99 | 131 | 69702 | 12628 | 29492066 |
Light chain analysis increased | 85.92 | 12.99 | 45 | 69788 | 1056 | 29503638 |
Product use in unapproved indication | 84.29 | 12.99 | 417 | 69416 | 86458 | 29418236 |
Rhabdomyolysis | 84.27 | 12.99 | 20 | 69813 | 60788 | 29443906 |
Headache | 82.70 | 12.99 | 180 | 69653 | 173827 | 29330867 |
Rash | 82.40 | 12.99 | 745 | 69088 | 189074 | 29315620 |
Ileus paralytic | 81.95 | 12.99 | 80 | 69753 | 5143 | 29499551 |
Amyloidosis | 77.39 | 12.99 | 52 | 69781 | 1952 | 29502742 |
Full blood count decreased | 77.38 | 12.99 | 137 | 69696 | 15855 | 29488839 |
Thrombosis | 76.80 | 12.99 | 250 | 69583 | 42795 | 29461899 |
Myelodysplastic syndrome | 74.23 | 12.99 | 143 | 69690 | 17651 | 29487043 |
Pancytopenia | 74.23 | 12.99 | 390 | 69443 | 82778 | 29421916 |
Osteonecrosis of jaw | 72.98 | 12.99 | 136 | 69697 | 16374 | 29488320 |
Blood creatine phosphokinase increased | 65.72 | 12.99 | 9 | 69824 | 40635 | 29464059 |
Off label use | 62.71 | 12.99 | 1027 | 68806 | 299773 | 29204921 |
Pyrexia | 62.56 | 12.99 | 989 | 68844 | 286633 | 29218061 |
Therapy partial responder | 60.70 | 12.99 | 68 | 69765 | 5131 | 29499563 |
Adverse drug reaction | 59.64 | 12.99 | 157 | 69676 | 23863 | 29480831 |
Inappropriate schedule of product administration | 58.96 | 12.99 | 16 | 69817 | 44456 | 29460238 |
Arthralgia | 57.92 | 12.99 | 155 | 69678 | 139462 | 29365232 |
Plasma cell myeloma refractory | 56.45 | 12.99 | 17 | 69816 | 80 | 29504614 |
Neuralgia | 56.32 | 12.99 | 96 | 69737 | 10778 | 29493916 |
Depression | 55.24 | 12.99 | 72 | 69761 | 85075 | 29419619 |
Hypertension | 55.03 | 12.99 | 121 | 69712 | 116493 | 29388201 |
B precursor type acute leukaemia | 53.91 | 12.99 | 18 | 69815 | 125 | 29504569 |
Atrial fibrillation | 53.83 | 12.99 | 430 | 69403 | 105216 | 29399478 |
Spinal compression fracture | 53.58 | 12.99 | 69 | 69764 | 6025 | 29498669 |
Chalazion | 53.03 | 12.99 | 17 | 69816 | 102 | 29504592 |
Infection | 52.83 | 12.99 | 336 | 69497 | 76415 | 29428279 |
Hypoaesthesia | 52.77 | 12.99 | 258 | 69575 | 53209 | 29451485 |
Aggression | 52.69 | 12.99 | 10 | 69823 | 35531 | 29469163 |
Psoriasis | 52.43 | 12.99 | 7 | 69826 | 32220 | 29472474 |
Cytopenia | 49.69 | 12.99 | 86 | 69747 | 9773 | 29494921 |
Protein total increased | 48.18 | 12.99 | 40 | 69793 | 2078 | 29502616 |
Sepsis | 47.76 | 12.99 | 531 | 69302 | 142151 | 29362543 |
Spinal cord compression | 47.32 | 12.99 | 50 | 69783 | 3532 | 29501162 |
Condition aggravated | 47.00 | 12.99 | 182 | 69651 | 146113 | 29358581 |
Seizure | 46.98 | 12.99 | 93 | 69740 | 93030 | 29411664 |
Drug hypersensitivity | 46.28 | 12.99 | 56 | 69777 | 68350 | 29436344 |
Primary amyloidosis | 45.32 | 12.99 | 15 | 69818 | 101 | 29504593 |
Laboratory test abnormal | 45.28 | 12.99 | 119 | 69714 | 18066 | 29486628 |
Blood pressure increased | 45.25 | 12.99 | 65 | 69768 | 73738 | 29430956 |
Suicidal ideation | 45.07 | 12.99 | 13 | 69820 | 34703 | 29469991 |
Abdominal pain | 45.03 | 12.99 | 166 | 69667 | 135191 | 29369503 |
Anxiety | 44.14 | 12.99 | 84 | 69749 | 85281 | 29419413 |
Stem cell transplant | 44.11 | 12.99 | 37 | 69796 | 1950 | 29502744 |
Cardiac amyloidosis | 43.68 | 12.99 | 27 | 69806 | 876 | 29503818 |
Compression fracture | 41.84 | 12.99 | 41 | 69792 | 2647 | 29502047 |
Septic shock | 41.27 | 12.99 | 271 | 69562 | 62289 | 29442405 |
Wrong technique in product usage process | 40.37 | 12.99 | 12 | 69821 | 31416 | 29473278 |
Paraesthesia | 40.35 | 12.99 | 241 | 69592 | 53604 | 29451090 |
Neutrophil count decreased | 39.99 | 12.99 | 206 | 69627 | 43361 | 29461333 |
Ageusia | 39.96 | 12.99 | 74 | 69759 | 8864 | 29495830 |
Peripheral sensorimotor neuropathy | 39.88 | 12.99 | 30 | 69803 | 1349 | 29503345 |
Hypoglycaemia | 39.02 | 12.99 | 34 | 69799 | 48312 | 29456382 |
Metapneumovirus infection | 38.79 | 12.99 | 22 | 69811 | 607 | 29504087 |
Hyperviscosity syndrome | 38.33 | 12.99 | 15 | 69818 | 172 | 29504522 |
Pathological fracture | 37.64 | 12.99 | 46 | 69787 | 3809 | 29500885 |
Rash pruritic | 37.30 | 12.99 | 127 | 69706 | 22236 | 29482458 |
Hypogammaglobulinaemia | 37.20 | 12.99 | 57 | 69776 | 5850 | 29498844 |
Cystitis haemorrhagic | 36.71 | 12.99 | 51 | 69782 | 4791 | 29499903 |
Osteolysis | 36.52 | 12.99 | 30 | 69803 | 1535 | 29503159 |
Haematochezia | 36.43 | 12.99 | 21 | 69812 | 36962 | 29467732 |
Monoclonal immunoglobulin present | 36.38 | 12.99 | 24 | 69809 | 873 | 29503821 |
Bradycardia | 35.32 | 12.99 | 63 | 69770 | 65566 | 29439128 |
Oroantral fistula | 33.26 | 12.99 | 14 | 69819 | 196 | 29504498 |
Hiccups | 33.13 | 12.99 | 68 | 69765 | 8785 | 29495909 |
Adenocarcinoma of colon | 32.94 | 12.99 | 38 | 69795 | 2960 | 29501734 |
Guillain-Barre syndrome | 32.12 | 12.99 | 49 | 69784 | 5009 | 29499685 |
Hallucination | 31.97 | 12.99 | 35 | 69798 | 44677 | 29460017 |
Stress | 31.95 | 12.99 | 6 | 69827 | 21484 | 29483210 |
Asthenia | 31.94 | 12.99 | 698 | 69135 | 214552 | 29290142 |
Bone pain | 31.84 | 12.99 | 106 | 69727 | 18346 | 29486348 |
Dehydration | 31.34 | 12.99 | 411 | 69422 | 114337 | 29390357 |
Squamous cell carcinoma of skin | 31.05 | 12.99 | 69 | 69764 | 9417 | 29495277 |
Flushing | 30.71 | 12.99 | 15 | 69818 | 28977 | 29475717 |
Pulmonary embolism | 30.37 | 12.99 | 295 | 69538 | 76239 | 29428455 |
Bone disorder | 29.87 | 12.99 | 51 | 69782 | 5732 | 29498962 |
Ileus | 29.70 | 12.99 | 88 | 69745 | 14314 | 29490380 |
Agitation | 29.68 | 12.99 | 47 | 69786 | 51257 | 29453437 |
Intentional product misuse | 29.67 | 12.99 | 23 | 69810 | 34638 | 29470056 |
Hyperkalaemia | 29.51 | 12.99 | 63 | 69770 | 61329 | 29443365 |
Blood stem cell harvest failure | 29.17 | 12.99 | 7 | 69826 | 10 | 29504684 |
Peripheral motor neuropathy | 28.96 | 12.99 | 27 | 69806 | 1638 | 29503056 |
Electrocardiogram QT prolonged | 28.46 | 12.99 | 26 | 69807 | 36111 | 29468583 |
Renal failure | 28.41 | 12.99 | 415 | 69418 | 118184 | 29386510 |
Asthma | 28.30 | 12.99 | 23 | 69810 | 33826 | 29470868 |
Osteonecrosis | 28.25 | 12.99 | 83 | 69750 | 13436 | 29491258 |
Angioedema | 27.55 | 12.99 | 21 | 69812 | 31894 | 29472800 |
Bacterial infection | 27.54 | 12.99 | 80 | 69753 | 12868 | 29491826 |
Bone marrow failure | 27.45 | 12.99 | 133 | 69700 | 27316 | 29477378 |
Contraindicated product administered | 27.37 | 12.99 | 5 | 69828 | 18261 | 29486433 |
Hordeolum | 26.97 | 12.99 | 19 | 69814 | 771 | 29503923 |
Malaise | 26.92 | 12.99 | 244 | 69589 | 159358 | 29345336 |
Bacteraemia | 26.61 | 12.99 | 92 | 69741 | 16231 | 29488463 |
Diverticular perforation | 26.56 | 12.99 | 34 | 69799 | 2950 | 29501744 |
Meningitis pneumococcal | 26.53 | 12.99 | 11 | 69822 | 148 | 29504546 |
Drug-induced liver injury | 26.51 | 12.99 | 9 | 69824 | 21646 | 29483048 |
Visceral leishmaniasis | 26.42 | 12.99 | 16 | 69817 | 500 | 29504194 |
Respirovirus test positive | 26.42 | 12.99 | 9 | 69824 | 67 | 29504627 |
Erythema | 26.26 | 12.99 | 91 | 69742 | 75515 | 29429179 |
Therapy non-responder | 26.20 | 12.99 | 143 | 69690 | 30768 | 29473926 |
VIth nerve paralysis | 25.49 | 12.99 | 18 | 69815 | 733 | 29503961 |
Tooth deposit | 25.33 | 12.99 | 9 | 69824 | 77 | 29504617 |
Myocardial infarction | 25.08 | 12.99 | 155 | 69678 | 110141 | 29394553 |
Cytomegalovirus infection | 25.05 | 12.99 | 115 | 69718 | 23100 | 29481594 |
Progressive multifocal leukoencephalopathy | 24.78 | 12.99 | 60 | 69773 | 8659 | 29496035 |
Somnolence | 24.64 | 12.99 | 126 | 69707 | 93829 | 29410865 |
Metabolic acidosis | 24.25 | 12.99 | 32 | 69801 | 37630 | 29467064 |
Haemoglobin decreased | 23.92 | 12.99 | 374 | 69459 | 108001 | 29396693 |
Febrile neutropenia | 23.89 | 12.99 | 385 | 69448 | 111855 | 29392839 |
Hyperhidrosis | 23.56 | 12.99 | 76 | 69757 | 64464 | 29440230 |
Lactic acidosis | 23.53 | 12.99 | 22 | 69811 | 30225 | 29474469 |
Performance status decreased | 23.52 | 12.99 | 36 | 69797 | 3691 | 29501003 |
Incorrect dose administered | 23.38 | 12.99 | 26 | 69807 | 32958 | 29471736 |
H1N1 influenza | 23.12 | 12.99 | 18 | 69815 | 852 | 29503842 |
Gastric ulcer | 23.00 | 12.99 | 3 | 69830 | 14058 | 29490636 |
Bone lesion | 22.81 | 12.99 | 30 | 69803 | 2674 | 29502020 |
Anaphylactic reaction | 22.72 | 12.99 | 19 | 69814 | 27554 | 29477140 |
Drug level increased | 22.67 | 12.99 | 8 | 69825 | 18779 | 29485915 |
Injection site pain | 22.53 | 12.99 | 26 | 69807 | 32420 | 29472274 |
Parainfluenzae virus infection | 22.22 | 12.99 | 27 | 69806 | 2222 | 29502472 |
Mobility decreased | 22.20 | 12.99 | 17 | 69816 | 25763 | 29478931 |
Spinal fracture | 22.16 | 12.99 | 48 | 69785 | 6438 | 29498256 |
Pallor | 22.08 | 12.99 | 11 | 69822 | 21013 | 29483681 |
Respiratory tract infection | 21.94 | 12.99 | 84 | 69749 | 15567 | 29489127 |
Anaemia | 21.85 | 12.99 | 625 | 69208 | 200326 | 29304368 |
Gastrointestinal amyloidosis | 21.79 | 12.99 | 6 | 69827 | 19 | 29504675 |
Abnormal behaviour | 21.57 | 12.99 | 14 | 69819 | 23113 | 29481581 |
Dysarthria | 21.22 | 12.99 | 25 | 69808 | 30886 | 29473808 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 21.20 | 12.99 | 15 | 69818 | 613 | 29504081 |
Brief psychotic disorder with marked stressors | 21.15 | 12.99 | 10 | 69823 | 187 | 29504507 |
Rib fracture | 21.00 | 12.99 | 72 | 69761 | 12646 | 29492048 |
Drug ineffective | 20.98 | 12.99 | 676 | 69157 | 362494 | 29142200 |
Neurogenic bladder | 20.66 | 12.99 | 22 | 69811 | 1568 | 29503126 |
Cytomegalovirus infection reactivation | 20.54 | 12.99 | 32 | 69801 | 3332 | 29501362 |
Rectal adenocarcinoma | 20.43 | 12.99 | 16 | 69817 | 764 | 29503930 |
Monoclonal gammopathy | 20.41 | 12.99 | 11 | 69822 | 274 | 29504420 |
Emotional distress | 20.40 | 12.99 | 4 | 69829 | 13891 | 29490803 |
Clostridium difficile colitis | 20.27 | 12.99 | 73 | 69760 | 13139 | 29491555 |
Colitis ulcerative | 20.23 | 12.99 | 3 | 69830 | 12766 | 29491928 |
Palmar-plantar erythrodysaesthesia syndrome | 20.15 | 12.99 | 5 | 69828 | 14754 | 29489940 |
Myalgia | 20.12 | 12.99 | 98 | 69735 | 73921 | 29430773 |
Blood pressure fluctuation | 20.02 | 12.99 | 11 | 69822 | 19883 | 29484811 |
Blood immunoglobulin A increased | 19.98 | 12.99 | 11 | 69822 | 286 | 29504408 |
Coronary artery disease | 19.88 | 12.99 | 47 | 69786 | 44143 | 29460551 |
Acute febrile neutrophilic dermatosis | 19.81 | 12.99 | 18 | 69815 | 1056 | 29503638 |
Autologous haematopoietic stem cell transplant | 19.79 | 12.99 | 5 | 69828 | 10 | 29504684 |
Conjunctival irritation | 19.75 | 12.99 | 8 | 69825 | 101 | 29504593 |
Wheezing | 19.65 | 12.99 | 30 | 69803 | 33210 | 29471484 |
Respiratory depression | 19.63 | 12.99 | 4 | 69829 | 13519 | 29491175 |
Infusion related reaction | 19.32 | 12.99 | 173 | 69660 | 43713 | 29460981 |
Basal cell carcinoma | 19.17 | 12.99 | 85 | 69748 | 16825 | 29487869 |
Demyelinating polyneuropathy | 18.84 | 12.99 | 18 | 69815 | 1126 | 29503568 |
Blood calcium increased | 18.79 | 12.99 | 30 | 69803 | 3189 | 29501505 |
Accidental overdose | 18.78 | 12.99 | 9 | 69824 | 17584 | 29487110 |
Jaundice | 18.75 | 12.99 | 25 | 69808 | 29271 | 29475423 |
Disturbance in attention | 18.61 | 12.99 | 14 | 69819 | 21410 | 29483284 |
Blood lactate dehydrogenase increased | 18.44 | 12.99 | 92 | 69741 | 19117 | 29485577 |
Musculoskeletal stiffness | 18.36 | 12.99 | 38 | 69795 | 37420 | 29467274 |
Pleuritic pain | 18.25 | 12.99 | 28 | 69805 | 2877 | 29501817 |
Blood immunoglobulin M increased | 18.13 | 12.99 | 9 | 69824 | 188 | 29504506 |
Cerebrovascular accident | 18.04 | 12.99 | 107 | 69726 | 76804 | 29427890 |
Product prescribing error | 18.00 | 12.99 | 10 | 69823 | 17966 | 29486728 |
Respiratory arrest | 17.62 | 12.99 | 21 | 69812 | 25812 | 29478882 |
Enterococcal infection | 17.50 | 12.99 | 51 | 69782 | 8217 | 29496477 |
Acute lymphocytic leukaemia | 17.44 | 12.99 | 26 | 69807 | 2605 | 29502089 |
Tachycardia | 17.38 | 12.99 | 100 | 69733 | 72310 | 29432384 |
Acute myeloid leukaemia | 17.22 | 12.99 | 81 | 69752 | 16432 | 29488262 |
Hallucination, visual | 17.10 | 12.99 | 7 | 69826 | 15008 | 29489686 |
Blood immunoglobulin G increased | 16.86 | 12.99 | 15 | 69818 | 856 | 29503838 |
Depressed level of consciousness | 16.85 | 12.99 | 39 | 69794 | 36903 | 29467791 |
Haematotoxicity | 16.84 | 12.99 | 44 | 69789 | 6655 | 29498039 |
Peripheral swelling | 16.83 | 12.99 | 227 | 69606 | 63512 | 29441182 |
Cardiac arrest | 16.61 | 12.99 | 126 | 69707 | 85465 | 29419229 |
Autonomic nervous system imbalance | 16.50 | 12.99 | 24 | 69809 | 2352 | 29502342 |
Neutropenic sepsis | 16.49 | 12.99 | 63 | 69770 | 11664 | 29493030 |
Adenovirus infection | 16.45 | 12.99 | 34 | 69799 | 4413 | 29500281 |
Blepharitis | 16.44 | 12.99 | 16 | 69817 | 1024 | 29503670 |
Sopor | 16.36 | 12.99 | 3 | 69830 | 10931 | 29493763 |
Dyskinesia | 16.31 | 12.99 | 14 | 69819 | 20047 | 29484647 |
Synovitis | 16.27 | 12.99 | 3 | 69830 | 10887 | 29493807 |
Pleural effusion | 16.17 | 12.99 | 249 | 69584 | 71659 | 29433035 |
Laryngeal cancer metastatic | 16.15 | 12.99 | 6 | 69827 | 59 | 29504635 |
Renal amyloidosis | 16.15 | 12.99 | 6 | 69827 | 59 | 29504635 |
Haematuria | 16.09 | 12.99 | 52 | 69781 | 44087 | 29460607 |
Haemorrhagic fever | 16.04 | 12.99 | 5 | 69828 | 27 | 29504667 |
Full blood count increased | 16.02 | 12.99 | 14 | 69819 | 780 | 29503914 |
Type 2 diabetes mellitus | 16.02 | 12.99 | 6 | 69827 | 13575 | 29491119 |
Genital erythema | 15.99 | 12.99 | 8 | 69825 | 170 | 29504524 |
Accidental exposure to product | 15.99 | 12.99 | 3 | 69830 | 10750 | 29493944 |
Loss of personal independence in daily activities | 15.98 | 12.99 | 22 | 69811 | 25418 | 29479276 |
Taste disorder | 15.92 | 12.99 | 35 | 69798 | 4741 | 29499953 |
Medication error | 15.84 | 12.99 | 16 | 69817 | 21195 | 29483499 |
Nephrolithiasis | 15.82 | 12.99 | 22 | 69811 | 25312 | 29479382 |
Hyperlipidaemia | 15.82 | 12.99 | 5 | 69828 | 12585 | 29492109 |
COVID-19 pneumonia | 15.81 | 12.99 | 54 | 69779 | 9468 | 29495226 |
Fat tissue increased | 15.76 | 12.99 | 10 | 69823 | 340 | 29504354 |
Product quality issue | 15.69 | 12.99 | 9 | 69824 | 15886 | 29488808 |
Ascites | 15.65 | 12.99 | 40 | 69793 | 36579 | 29468115 |
Escherichia sepsis | 15.57 | 12.99 | 31 | 69802 | 3918 | 29500776 |
Gastrooesophageal reflux disease | 15.40 | 12.99 | 32 | 69801 | 31464 | 29473230 |
Morganella infection | 15.32 | 12.99 | 11 | 69822 | 460 | 29504234 |
Depressed mood | 15.28 | 12.99 | 10 | 69823 | 16438 | 29488256 |
Melaena | 14.97 | 12.99 | 32 | 69801 | 31144 | 29473550 |
Light chain analysis decreased | 14.94 | 12.99 | 5 | 69828 | 35 | 29504659 |
Aphasia | 14.89 | 12.99 | 14 | 69819 | 19184 | 29485510 |
Heart rate increased | 14.81 | 12.99 | 45 | 69788 | 38893 | 29465801 |
Body height decreased | 14.72 | 12.99 | 28 | 69805 | 3422 | 29501272 |
Coma | 14.71 | 12.99 | 46 | 69787 | 39404 | 29465290 |
Refractory cytopenia with multilineage dysplasia | 14.70 | 12.99 | 7 | 69826 | 133 | 29504561 |
Blood culture positive | 14.65 | 12.99 | 33 | 69800 | 4544 | 29500150 |
Blood pressure systolic increased | 14.64 | 12.99 | 11 | 69822 | 16834 | 29487860 |
Injury | 14.64 | 12.99 | 14 | 69819 | 19032 | 29485662 |
Diabetic ketoacidosis | 14.62 | 12.99 | 10 | 69823 | 16063 | 29488631 |
Refractory anaemia with an excess of blasts | 14.61 | 12.99 | 10 | 69823 | 387 | 29504307 |
Obstructive airways disorder | 14.53 | 12.99 | 4 | 69829 | 11012 | 29493682 |
Cellulitis orbital | 14.45 | 12.99 | 9 | 69824 | 296 | 29504398 |
JC virus infection | 14.41 | 12.99 | 20 | 69813 | 1877 | 29502817 |
Oesophageal adenocarcinoma | 14.18 | 12.99 | 13 | 69820 | 772 | 29503922 |
Colitis | 14.18 | 12.99 | 124 | 69709 | 31124 | 29473570 |
Extrapyramidal disorder | 14.16 | 12.99 | 4 | 69829 | 10827 | 29493867 |
Muscle spasms | 14.12 | 12.99 | 224 | 69609 | 64858 | 29439836 |
Hepatitis | 14.06 | 12.99 | 17 | 69816 | 20766 | 29483928 |
Pregnancy of partner | 14.05 | 12.99 | 9 | 69824 | 311 | 29504383 |
VIth nerve paresis | 14.05 | 12.99 | 5 | 69828 | 43 | 29504651 |
Cholestasis | 14.04 | 12.99 | 21 | 69812 | 23441 | 29481253 |
Alanine aminotransferase increased | 13.97 | 12.99 | 104 | 69729 | 70840 | 29433854 |
Vomiting | 13.96 | 12.99 | 388 | 69445 | 211872 | 29292822 |
Dystonia | 13.91 | 12.99 | 3 | 69830 | 9746 | 29494948 |
Hypersensitivity | 13.83 | 12.99 | 71 | 69762 | 52832 | 29451862 |
Serratia sepsis | 13.80 | 12.99 | 4 | 69829 | 16 | 29504678 |
COVID-19 | 13.39 | 12.99 | 137 | 69696 | 35877 | 29468817 |
Spinal pain | 13.32 | 12.99 | 33 | 69800 | 4831 | 29499863 |
Pneumonia mycoplasmal | 13.31 | 12.99 | 11 | 69822 | 568 | 29504126 |
Hypercapnic coma | 13.30 | 12.99 | 7 | 69826 | 166 | 29504528 |
Hyposmia | 13.26 | 12.99 | 7 | 69826 | 167 | 29504527 |
Glomerular filtration rate decreased | 13.25 | 12.99 | 5 | 69828 | 11261 | 29493433 |
Glycosylated haemoglobin increased | 13.25 | 12.99 | 3 | 69830 | 9423 | 29495271 |
Meningioma | 13.10 | 12.99 | 16 | 69817 | 1324 | 29503370 |
Hypothyroidism | 13.06 | 12.99 | 11 | 69822 | 15895 | 29488799 |
Blood triglycerides increased | 13.05 | 12.99 | 7 | 69826 | 12827 | 29491867 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 3188.08 | 11.93 | 2104 | 100824 | 115421 | 64280383 |
Plasma cell myeloma | 2047.47 | 11.93 | 1134 | 101794 | 44941 | 64350863 |
Plasma cell myeloma recurrent | 1088.95 | 11.93 | 359 | 102569 | 3706 | 64392098 |
Thrombocytopenia | 998.85 | 11.93 | 1488 | 101440 | 222313 | 64173491 |
Platelet count decreased | 724.38 | 11.93 | 1099 | 101829 | 166612 | 64229192 |
Disease progression | 652.51 | 11.93 | 957 | 101971 | 140723 | 64255081 |
Polyneuropathy | 623.14 | 11.93 | 391 | 102537 | 19503 | 64376301 |
Pneumonia | 617.75 | 11.93 | 2125 | 100803 | 557451 | 63838353 |
Plasmacytoma | 551.09 | 11.93 | 214 | 102714 | 3656 | 64392148 |
Completed suicide | 332.37 | 11.93 | 5 | 102923 | 224409 | 64171395 |
Unevaluable event | 325.21 | 11.93 | 402 | 102526 | 50087 | 64345717 |
Plasma cell leukaemia | 313.55 | 11.93 | 111 | 102817 | 1442 | 64394362 |
Neutropenia | 307.68 | 11.93 | 960 | 101968 | 238664 | 64157140 |
Tumour lysis syndrome | 288.42 | 11.93 | 243 | 102685 | 19197 | 64376607 |
Diarrhoea | 266.88 | 11.93 | 2016 | 100912 | 720688 | 63675116 |
Drug interaction | 247.49 | 11.93 | 135 | 102793 | 361948 | 64033856 |
Product use in unapproved indication | 246.59 | 11.93 | 729 | 102199 | 175889 | 64219915 |
Rheumatoid arthritis | 246.10 | 11.93 | 3 | 102925 | 164291 | 64231513 |
White blood cell count decreased | 245.13 | 11.93 | 677 | 102251 | 157160 | 64238644 |
Peripheral sensory neuropathy | 244.32 | 11.93 | 177 | 102751 | 11201 | 64384603 |
Headache | 243.11 | 11.93 | 293 | 102635 | 529174 | 63866630 |
Arthralgia | 226.98 | 11.93 | 223 | 102705 | 442037 | 63953767 |
Pancytopenia | 222.80 | 11.93 | 615 | 102313 | 142694 | 64253110 |
Orthostatic hypotension | 219.46 | 11.93 | 319 | 102609 | 46419 | 64349385 |
Drug hypersensitivity | 214.95 | 11.93 | 57 | 102871 | 237758 | 64158046 |
Constipation | 204.46 | 11.93 | 815 | 102113 | 228522 | 64167282 |
Sepsis | 203.30 | 11.93 | 816 | 102112 | 229525 | 64166279 |
Off label use | 196.55 | 11.93 | 1698 | 101230 | 631108 | 63764696 |
Amyloidosis | 188.47 | 11.93 | 88 | 102840 | 2406 | 64393398 |
Deep vein thrombosis | 185.34 | 11.93 | 473 | 102455 | 104709 | 64291095 |
Herpes zoster | 179.62 | 11.93 | 393 | 102535 | 78794 | 64317010 |
Septic shock | 160.35 | 11.93 | 449 | 102479 | 104988 | 64290816 |
Drug abuse | 159.44 | 11.93 | 14 | 102914 | 132360 | 64263444 |
Myelodysplastic syndrome | 157.63 | 11.93 | 207 | 102721 | 27372 | 64368432 |
Febrile neutropenia | 154.58 | 11.93 | 651 | 102277 | 187006 | 64208798 |
Autonomic neuropathy | 149.20 | 11.93 | 66 | 102862 | 1586 | 64394218 |
Overdose | 146.50 | 11.93 | 37 | 102891 | 159529 | 64236275 |
Synovitis | 143.35 | 11.93 | 3 | 102925 | 99087 | 64296717 |
Maternal exposure during pregnancy | 138.33 | 11.93 | 3 | 102925 | 95881 | 64299923 |
Light chain analysis increased | 136.93 | 11.93 | 58 | 102870 | 1250 | 64394554 |
Neutrophil count decreased | 136.82 | 11.93 | 348 | 102580 | 76848 | 64318956 |
Contraindicated product administered | 136.65 | 11.93 | 9 | 102919 | 107820 | 64287984 |
Cardiac amyloidosis | 135.79 | 11.93 | 59 | 102869 | 1356 | 64394448 |
Ileus paralytic | 134.81 | 11.93 | 110 | 102818 | 8305 | 64387499 |
Anaemia | 129.30 | 11.93 | 1039 | 101889 | 377641 | 64018163 |
Atrial fibrillation | 128.98 | 11.93 | 578 | 102350 | 170511 | 64225293 |
Pyrexia | 128.30 | 11.93 | 1408 | 101520 | 557236 | 63838568 |
Dehydration | 125.39 | 11.93 | 679 | 102249 | 216084 | 64179720 |
Cytopenia | 124.24 | 11.93 | 138 | 102790 | 15333 | 64380471 |
Chalazion | 118.73 | 11.93 | 39 | 102889 | 397 | 64395407 |
Pain | 118.23 | 11.93 | 469 | 102459 | 553042 | 63842762 |
Therapy partial responder | 114.16 | 11.93 | 109 | 102819 | 10139 | 64385665 |
Full blood count decreased | 110.17 | 11.93 | 157 | 102771 | 22425 | 64373379 |
Systemic lupus erythematosus | 109.76 | 11.93 | 3 | 102925 | 77609 | 64318195 |
Product use issue | 109.45 | 11.93 | 506 | 102422 | 151209 | 64244595 |
Alopecia | 107.00 | 11.93 | 66 | 102862 | 165624 | 64230180 |
Hypercalcaemia | 106.77 | 11.93 | 185 | 102743 | 31231 | 64364573 |
Exposure during pregnancy | 106.29 | 11.93 | 4 | 102924 | 77671 | 64318133 |
Arthropathy | 105.47 | 11.93 | 31 | 102897 | 120936 | 64274868 |
Condition aggravated | 102.56 | 11.93 | 282 | 102646 | 372144 | 64023660 |
Joint swelling | 101.96 | 11.93 | 116 | 102812 | 215266 | 64180538 |
Anxiety | 97.17 | 11.93 | 108 | 102820 | 202541 | 64193263 |
Psoriasis | 97.07 | 11.93 | 4 | 102924 | 71699 | 64324105 |
Musculoskeletal stiffness | 94.65 | 11.93 | 39 | 102889 | 123167 | 64272637 |
Blood pressure increased | 93.00 | 11.93 | 83 | 102845 | 172469 | 64223335 |
Suicide attempt | 92.77 | 11.93 | 5 | 102923 | 71002 | 64324802 |
Renal failure | 92.40 | 11.93 | 550 | 102378 | 181138 | 64214666 |
Hypersensitivity | 90.61 | 11.93 | 108 | 102820 | 196344 | 64199460 |
Malignant neoplasm progression | 88.54 | 11.93 | 386 | 102542 | 112485 | 64283319 |
Therapeutic product effect decreased | 87.82 | 11.93 | 37 | 102891 | 115314 | 64280490 |
Glossodynia | 86.29 | 11.93 | 4 | 102924 | 64692 | 64331112 |
Peripheral sensorimotor neuropathy | 83.91 | 11.93 | 52 | 102876 | 2533 | 64393271 |
Stem cell transplant | 83.62 | 11.93 | 58 | 102870 | 3423 | 64392381 |
Cytomegalovirus infection | 83.59 | 11.93 | 184 | 102744 | 37015 | 64358789 |
Injection site pain | 82.81 | 11.93 | 37 | 102891 | 111371 | 64284433 |
Swelling | 81.72 | 11.93 | 81 | 102847 | 160137 | 64235667 |
Thrombosis | 80.43 | 11.93 | 272 | 102656 | 70370 | 64325434 |
Pathological fracture | 78.71 | 11.93 | 84 | 102844 | 8921 | 64386883 |
Primary amyloidosis | 77.84 | 11.93 | 21 | 102907 | 99 | 64395705 |
Hyperviscosity syndrome | 77.31 | 11.93 | 27 | 102901 | 336 | 64395468 |
Rhabdomyolysis | 75.52 | 11.93 | 26 | 102902 | 91700 | 64304104 |
Cytomegalovirus infection reactivation | 73.36 | 11.93 | 66 | 102862 | 5690 | 64390114 |
Abdominal discomfort | 73.15 | 11.93 | 111 | 102817 | 182211 | 64213593 |
Depression | 73.14 | 11.93 | 112 | 102816 | 183179 | 64212625 |
Pleural effusion | 72.78 | 11.93 | 396 | 102532 | 126163 | 64269641 |
Peripheral motor neuropathy | 72.55 | 11.93 | 50 | 102878 | 2920 | 64392884 |
Bone marrow failure | 71.65 | 11.93 | 203 | 102725 | 47749 | 64348055 |
Spinal cord compression | 69.95 | 11.93 | 64 | 102864 | 5639 | 64390165 |
Mobility decreased | 69.52 | 11.93 | 25 | 102903 | 85815 | 64309989 |
Haemoglobin decreased | 69.01 | 11.93 | 540 | 102388 | 194523 | 64201281 |
Wrong technique in product usage process | 68.05 | 11.93 | 11 | 102917 | 64963 | 64330841 |
Wound | 67.76 | 11.93 | 19 | 102909 | 76458 | 64319346 |
Blood stem cell harvest failure | 67.58 | 11.93 | 18 | 102910 | 80 | 64395724 |
Monoclonal immunoglobulin present | 67.54 | 11.93 | 31 | 102897 | 814 | 64394990 |
Discomfort | 66.45 | 11.93 | 23 | 102905 | 80855 | 64314949 |
Posterior reversible encephalopathy syndrome | 66.36 | 11.93 | 126 | 102802 | 22820 | 64372984 |
Malaise | 66.01 | 11.93 | 367 | 102561 | 395880 | 63999924 |
Plasma cell myeloma refractory | 65.52 | 11.93 | 18 | 102910 | 92 | 64395712 |
Osteonecrosis of jaw | 64.86 | 11.93 | 174 | 102754 | 39651 | 64356153 |
B precursor type acute leukaemia | 62.76 | 11.93 | 22 | 102906 | 277 | 64395527 |
Pulmonary embolism | 62.57 | 11.93 | 424 | 102504 | 145932 | 64249872 |
Colitis | 62.50 | 11.93 | 221 | 102707 | 58453 | 64337351 |
Protein total increased | 62.32 | 11.93 | 48 | 102880 | 3333 | 64392471 |
Weight increased | 62.10 | 11.93 | 157 | 102771 | 213191 | 64182613 |
Osteolysis | 61.07 | 11.93 | 44 | 102884 | 2759 | 64393045 |
Blood pressure fluctuation | 61.06 | 11.93 | 6 | 102922 | 51865 | 64343939 |
Therapy non-responder | 60.82 | 11.93 | 237 | 102691 | 65662 | 64330142 |
Hordeolum | 60.31 | 11.93 | 40 | 102888 | 2192 | 64393612 |
Stress | 59.61 | 11.93 | 12 | 102916 | 60522 | 64335282 |
Hypertension | 59.51 | 11.93 | 213 | 102715 | 259048 | 64136756 |
Blood lactate dehydrogenase increased | 59.49 | 11.93 | 150 | 102778 | 32928 | 64362876 |
Blood creatine phosphokinase increased | 58.95 | 11.93 | 11 | 102917 | 58547 | 64337257 |
Coombs indirect test positive | 58.61 | 11.93 | 15 | 102913 | 55 | 64395749 |
Inappropriate schedule of product administration | 57.85 | 11.93 | 38 | 102890 | 92248 | 64303556 |
Haematotoxicity | 57.58 | 11.93 | 86 | 102842 | 12810 | 64382994 |
Flushing | 55.55 | 11.93 | 28 | 102900 | 78620 | 64317184 |
Hypogammaglobulinaemia | 55.31 | 11.93 | 75 | 102853 | 10224 | 64385580 |
Cardiac failure | 54.50 | 11.93 | 380 | 102548 | 131993 | 64263811 |
Guillain-Barre syndrome | 54.36 | 11.93 | 64 | 102864 | 7571 | 64388233 |
Ileus | 53.19 | 11.93 | 115 | 102813 | 22851 | 64372953 |
Arthritis | 50.55 | 11.93 | 36 | 102892 | 83778 | 64312026 |
Metapneumovirus infection | 48.98 | 11.93 | 30 | 102898 | 1431 | 64394373 |
Hepatitis B reactivation | 48.85 | 11.93 | 49 | 102879 | 4840 | 64390964 |
Hepatic enzyme increased | 48.44 | 11.93 | 83 | 102845 | 129860 | 64265944 |
Infection | 47.84 | 11.93 | 478 | 102450 | 184402 | 64211402 |
Renal amyloidosis | 47.31 | 11.93 | 15 | 102913 | 135 | 64395669 |
Nasopharyngitis | 47.06 | 11.93 | 158 | 102770 | 195915 | 64199889 |
Suicidal ideation | 46.53 | 11.93 | 24 | 102904 | 66518 | 64329286 |
Bacteraemia | 46.28 | 11.93 | 120 | 102808 | 26791 | 64369013 |
Bone pain | 46.28 | 11.93 | 174 | 102754 | 47398 | 64348406 |
Migraine | 46.27 | 11.93 | 21 | 102907 | 62656 | 64333148 |
Anaphylactic reaction | 46.21 | 11.93 | 26 | 102902 | 68638 | 64327166 |
Treatment failure | 45.99 | 11.93 | 72 | 102856 | 116744 | 64279060 |
Compression fracture | 45.65 | 11.93 | 51 | 102877 | 5701 | 64390103 |
Neuralgia | 45.28 | 11.93 | 117 | 102811 | 26067 | 64369737 |
Morganella infection | 45.25 | 11.93 | 25 | 102903 | 981 | 64394823 |
Blood cholesterol increased | 45.17 | 11.93 | 12 | 102916 | 50054 | 64345750 |
Drug ineffective | 44.35 | 11.93 | 1013 | 101915 | 839234 | 63556570 |
Acute lymphocytic leukaemia | 44.02 | 11.93 | 44 | 102884 | 4327 | 64391477 |
Aggression | 43.81 | 11.93 | 10 | 102918 | 46222 | 64349582 |
Helicobacter infection | 43.71 | 11.93 | 5 | 102923 | 38357 | 64357447 |
Gastrooesophageal reflux disease | 43.57 | 11.93 | 41 | 102887 | 83102 | 64312702 |
Squamous cell carcinoma of skin | 43.07 | 11.93 | 72 | 102856 | 11804 | 64384000 |
Injury | 42.54 | 11.93 | 18 | 102910 | 55974 | 64339830 |
Hypocalcaemia | 42.53 | 11.93 | 155 | 102773 | 41598 | 64354206 |
Asthenia | 42.24 | 11.93 | 936 | 101992 | 427108 | 63968696 |
Myalgia | 42.17 | 11.93 | 122 | 102806 | 158495 | 64237309 |
Somnolence | 41.77 | 11.93 | 175 | 102753 | 203470 | 64192334 |
Acute myeloid leukaemia | 41.74 | 11.93 | 117 | 102811 | 27346 | 64368458 |
Respiratory tract infection | 41.65 | 11.93 | 143 | 102785 | 37264 | 64358540 |
Sedation | 41.28 | 11.93 | 8 | 102920 | 41454 | 64354350 |
Pruritus | 40.48 | 11.93 | 312 | 102616 | 312088 | 64083716 |
Erythema | 40.09 | 11.93 | 158 | 102770 | 186912 | 64208892 |
Blister | 40.05 | 11.93 | 42 | 102886 | 80925 | 64314879 |
Large intestine perforation | 39.95 | 11.93 | 72 | 102856 | 12532 | 64383272 |
Irritable bowel syndrome | 39.87 | 11.93 | 6 | 102922 | 37363 | 64358441 |
Crossmatch incompatible | 39.66 | 11.93 | 10 | 102918 | 34 | 64395770 |
Wheezing | 39.63 | 11.93 | 42 | 102886 | 80537 | 64315267 |
Rash | 39.51 | 11.93 | 984 | 101944 | 457565 | 63938239 |
Spinal compression fracture | 38.91 | 11.93 | 78 | 102850 | 14697 | 64381107 |
Refractory cytopenia with multilineage dysplasia | 38.63 | 11.93 | 15 | 102913 | 256 | 64395548 |
Red blood cell sedimentation rate increased | 38.43 | 11.93 | 3 | 102925 | 31232 | 64364572 |
Performance status decreased | 38.25 | 11.93 | 45 | 102883 | 5319 | 64390485 |
Syncope | 38.12 | 11.93 | 402 | 102526 | 157233 | 64238571 |
Pneumonia fungal | 37.93 | 11.93 | 58 | 102870 | 8819 | 64386985 |
Blood pressure systolic increased | 37.40 | 11.93 | 16 | 102912 | 49437 | 64346367 |
Osteoarthritis | 37.16 | 11.93 | 28 | 102900 | 63308 | 64332496 |
Thrombotic microangiopathy | 36.98 | 11.93 | 82 | 102846 | 16573 | 64379231 |
Nasal congestion | 36.80 | 11.93 | 25 | 102903 | 59633 | 64336171 |
Heart rate increased | 36.80 | 11.93 | 63 | 102865 | 98612 | 64297192 |
Loss of personal independence in daily activities | 36.50 | 11.93 | 37 | 102891 | 72417 | 64323387 |
Sopor | 36.07 | 11.93 | 3 | 102925 | 29658 | 64366146 |
Diverticular perforation | 35.96 | 11.93 | 43 | 102885 | 5170 | 64390634 |
Hyperhidrosis | 35.50 | 11.93 | 93 | 102835 | 124827 | 64270977 |
Cystitis haemorrhagic | 35.44 | 11.93 | 53 | 102875 | 7903 | 64387901 |
Palpitations | 35.17 | 11.93 | 71 | 102857 | 104417 | 64291387 |
Hypophosphataemia | 34.42 | 11.93 | 74 | 102854 | 14646 | 64381158 |
Toxicity to various agents | 34.29 | 11.93 | 790 | 102138 | 362723 | 64033081 |
Sleep disorder | 34.26 | 11.93 | 27 | 102901 | 59682 | 64336122 |
Large intestinal ulcer perforation | 34.12 | 11.93 | 10 | 102918 | 67 | 64395737 |
Inappropriate antidiuretic hormone secretion | 33.91 | 11.93 | 95 | 102833 | 22194 | 64373610 |
Ill-defined disorder | 33.72 | 11.93 | 14 | 102914 | 44038 | 64351766 |
Lactic acidosis | 33.71 | 11.93 | 29 | 102899 | 61381 | 64334423 |
Drug withdrawal syndrome | 33.44 | 11.93 | 5 | 102923 | 31286 | 64364518 |
Contusion | 33.03 | 11.93 | 84 | 102844 | 113881 | 64281923 |
Mesenteric abscess | 32.97 | 11.93 | 11 | 102917 | 118 | 64395686 |
Nocardiosis | 32.36 | 11.93 | 39 | 102889 | 4728 | 64391076 |
VIth nerve paresis | 31.93 | 11.93 | 11 | 102917 | 131 | 64395673 |
Oedema peripheral | 31.93 | 11.93 | 492 | 102436 | 209825 | 64185979 |
Drug intolerance | 31.84 | 11.93 | 173 | 102755 | 187819 | 64207985 |
Pneumonia pneumococcal | 31.55 | 11.93 | 32 | 102896 | 3202 | 64392602 |
Abdominal pain upper | 31.37 | 11.93 | 158 | 102770 | 174872 | 64220932 |
Blood immunoglobulin A increased | 31.36 | 11.93 | 16 | 102912 | 533 | 64395271 |
Urticaria | 31.19 | 11.93 | 125 | 102803 | 147192 | 64248612 |
COVID-19 pneumonia | 30.89 | 11.93 | 76 | 102852 | 16428 | 64379376 |
Nasal abscess | 30.79 | 11.93 | 11 | 102917 | 147 | 64395657 |
Hypothyroidism | 30.74 | 11.93 | 13 | 102915 | 40444 | 64355360 |
Respiratory failure | 30.47 | 11.93 | 392 | 102536 | 160791 | 64235013 |
Clostridium difficile colitis | 30.25 | 11.93 | 104 | 102824 | 27119 | 64368685 |
Visceral leishmaniasis | 30.25 | 11.93 | 19 | 102909 | 948 | 64394856 |
Inflammation | 29.97 | 11.93 | 36 | 102892 | 65264 | 64330540 |
Neurotoxicity | 29.85 | 11.93 | 104 | 102824 | 27300 | 64368504 |
Hypoalbuminaemia | 29.56 | 11.93 | 78 | 102850 | 17596 | 64378208 |
Folliculitis | 29.53 | 11.93 | 6 | 102922 | 30071 | 64365733 |
Rib fracture | 29.53 | 11.93 | 95 | 102833 | 23943 | 64371861 |
Demyelinating polyneuropathy | 29.51 | 11.93 | 22 | 102906 | 1454 | 64394350 |
Product quality issue | 29.14 | 11.93 | 6 | 102922 | 29793 | 64366011 |
Endocarditis bacterial | 29.07 | 11.93 | 21 | 102907 | 1322 | 64394482 |
Body dysmorphic disorder | 28.84 | 11.93 | 12 | 102916 | 247 | 64395557 |
Injection site swelling | 28.78 | 11.93 | 15 | 102913 | 41338 | 64354466 |
Asthma | 28.52 | 11.93 | 69 | 102859 | 95156 | 64300648 |
Osteoporosis | 28.22 | 11.93 | 16 | 102912 | 42064 | 64353740 |
Hepatitis B | 28.14 | 11.93 | 47 | 102881 | 7698 | 64388106 |
Osteonecrosis | 28.08 | 11.93 | 104 | 102824 | 28125 | 64367679 |
Dysarthria | 28.07 | 11.93 | 32 | 102896 | 59374 | 64336430 |
Seizure | 28.03 | 11.93 | 154 | 102774 | 166738 | 64229066 |
Underdose | 27.90 | 11.93 | 4 | 102924 | 25825 | 64369979 |
Hypoglycaemia | 27.83 | 11.93 | 64 | 102864 | 89828 | 64305976 |
Failure to thrive | 27.49 | 11.93 | 55 | 102873 | 10349 | 64385455 |
Meningitis pneumococcal | 27.36 | 11.93 | 13 | 102915 | 370 | 64395434 |
Cough | 27.15 | 11.93 | 330 | 102598 | 301818 | 64093986 |
Mucosal inflammation | 27.13 | 11.93 | 182 | 102746 | 62402 | 64333402 |
Oroantral fistula | 27.10 | 11.93 | 13 | 102915 | 378 | 64395426 |
Rectal adenocarcinoma | 26.81 | 11.93 | 20 | 102908 | 1323 | 64394481 |
Bacterial sepsis | 26.76 | 11.93 | 45 | 102883 | 7412 | 64388392 |
Hiccups | 26.74 | 11.93 | 48 | 102880 | 8328 | 64387476 |
Abdominal pain | 26.63 | 11.93 | 345 | 102583 | 312030 | 64083774 |
Taste disorder | 26.29 | 11.93 | 51 | 102877 | 9382 | 64386422 |
Ageusia | 26.27 | 11.93 | 64 | 102864 | 13749 | 64382055 |
Pericarditis | 26.08 | 11.93 | 37 | 102891 | 62479 | 64333325 |
Progressive multifocal leukoencephalopathy | 26.08 | 11.93 | 76 | 102852 | 18156 | 64377648 |
Fatigue | 25.81 | 11.93 | 1450 | 101478 | 747280 | 63648524 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 25.79 | 11.93 | 17 | 102911 | 922 | 64394882 |
Fungal oesophagitis | 25.75 | 11.93 | 16 | 102912 | 783 | 64395021 |
Hypoaesthesia | 25.74 | 11.93 | 337 | 102591 | 138771 | 64257033 |
Feeling abnormal | 25.44 | 11.93 | 118 | 102810 | 133484 | 64262320 |
Oral surgery | 25.37 | 11.93 | 17 | 102911 | 948 | 64394856 |
Incorrect dose administered | 25.32 | 11.93 | 36 | 102892 | 60729 | 64335075 |
VIth nerve paralysis | 25.26 | 11.93 | 20 | 102908 | 1446 | 64394358 |
Adenocarcinoma of colon | 25.23 | 11.93 | 35 | 102893 | 4873 | 64390931 |
Blood immunoglobulin G increased | 25.23 | 11.93 | 22 | 102906 | 1819 | 64393985 |
Autonomic nervous system imbalance | 25.14 | 11.93 | 32 | 102896 | 4100 | 64391704 |
Target skin lesion | 25.14 | 11.93 | 9 | 102919 | 121 | 64395683 |
Lymphopenia | 25.08 | 11.93 | 94 | 102834 | 25563 | 64370241 |
Respirovirus test positive | 24.94 | 11.93 | 9 | 102919 | 124 | 64395680 |
Refractory anaemia with an excess of blasts | 24.91 | 11.93 | 16 | 102912 | 830 | 64394974 |
Gait disturbance | 24.65 | 11.93 | 167 | 102761 | 171988 | 64223816 |
Pain in extremity | 24.65 | 11.93 | 338 | 102590 | 302747 | 64093057 |
Iron deficiency anaemia | 24.57 | 11.93 | 3 | 102925 | 21886 | 64373918 |
Respiratory depression | 24.47 | 11.93 | 4 | 102924 | 23439 | 64372365 |
Blepharitis | 24.42 | 11.93 | 25 | 102903 | 2530 | 64393274 |
Clostridium bacteraemia | 24.32 | 11.93 | 11 | 102917 | 279 | 64395525 |
Chest discomfort | 24.27 | 11.93 | 99 | 102829 | 116007 | 64279797 |
Gastrointestinal fungal infection | 24.19 | 11.93 | 12 | 102916 | 376 | 64395428 |
Escherichia sepsis | 24.08 | 11.93 | 42 | 102886 | 7123 | 64388681 |
Enterococcal infection | 24.02 | 11.93 | 62 | 102866 | 13804 | 64382000 |
Colitis ulcerative | 23.88 | 11.93 | 4 | 102924 | 23024 | 64372780 |
Hip arthroplasty | 23.79 | 11.93 | 3 | 102925 | 21348 | 64374456 |
Diabetic ketoacidosis | 23.64 | 11.93 | 9 | 102919 | 29836 | 64365968 |
Dyskinesia | 23.64 | 11.93 | 17 | 102911 | 39371 | 64356433 |
Meningitis listeria | 23.62 | 11.93 | 15 | 102913 | 763 | 64395041 |
Accidental overdose | 23.61 | 11.93 | 12 | 102916 | 33545 | 64362259 |
Heart rate decreased | 23.57 | 11.93 | 32 | 102896 | 55035 | 64340769 |
Angioedema | 23.48 | 11.93 | 39 | 102889 | 61782 | 64334022 |
COVID-19 | 23.36 | 11.93 | 181 | 102747 | 64959 | 64330845 |
Drug-induced liver injury | 23.24 | 11.93 | 25 | 102903 | 47618 | 64348186 |
Lip swelling | 23.07 | 11.93 | 11 | 102917 | 31896 | 64363908 |
Hyperproteinaemia | 23.05 | 11.93 | 9 | 102919 | 156 | 64395648 |
Blood potassium decreased | 22.92 | 11.93 | 126 | 102802 | 40273 | 64355531 |
Meningitis cryptococcal | 22.72 | 11.93 | 26 | 102902 | 2983 | 64392821 |
Type 2 diabetes mellitus | 22.72 | 11.93 | 13 | 102915 | 34007 | 64361797 |
Electrolyte imbalance | 22.64 | 11.93 | 90 | 102838 | 25153 | 64370651 |
Obesity | 22.64 | 11.93 | 3 | 102925 | 20559 | 64375245 |
Laboratory test abnormal | 22.56 | 11.93 | 87 | 102841 | 23976 | 64371828 |
Swollen tongue | 22.44 | 11.93 | 14 | 102914 | 34940 | 64360864 |
Pneumonia cytomegaloviral | 22.40 | 11.93 | 31 | 102897 | 4308 | 64391496 |
Pseudomonal sepsis | 22.39 | 11.93 | 34 | 102894 | 5138 | 64390666 |
Nephrolithiasis | 22.35 | 11.93 | 22 | 102906 | 43661 | 64352143 |
Prescribed overdose | 22.31 | 11.93 | 3 | 102925 | 20328 | 64375476 |
Basal cell carcinoma | 22.30 | 11.93 | 103 | 102825 | 30735 | 64365069 |
Acute febrile neutrophilic dermatosis | 22.21 | 11.93 | 27 | 102901 | 3302 | 64392502 |
Impaired healing | 22.19 | 11.93 | 39 | 102889 | 60434 | 64335370 |
Neurogenic bladder | 21.98 | 11.93 | 28 | 102900 | 3591 | 64392213 |
Crying | 21.96 | 11.93 | 3 | 102925 | 20087 | 64375717 |
Depressed mood | 21.75 | 11.93 | 20 | 102908 | 40992 | 64354812 |
Hot flush | 21.74 | 11.93 | 25 | 102903 | 46210 | 64349594 |
Parainfluenzae virus infection | 21.71 | 11.93 | 32 | 102896 | 4711 | 64391093 |
Sinusitis | 21.68 | 11.93 | 140 | 102788 | 145788 | 64250016 |
Pallor | 21.67 | 11.93 | 18 | 102910 | 38763 | 64357041 |
Lung infiltration | 21.65 | 11.93 | 78 | 102850 | 20811 | 64374993 |
Bacterial infection | 21.62 | 11.93 | 88 | 102840 | 24862 | 64370942 |
Bradycardia | 21.58 | 11.93 | 106 | 102822 | 118113 | 64277691 |
Surgery | 21.54 | 11.93 | 9 | 102919 | 28204 | 64367600 |
End stage renal disease | 21.50 | 11.93 | 50 | 102878 | 10425 | 64385379 |
Medication error | 21.42 | 11.93 | 29 | 102899 | 49937 | 64345867 |
Depressed level of consciousness | 21.36 | 11.93 | 63 | 102865 | 81373 | 64314431 |
Superficial spreading melanoma stage unspecified | 21.36 | 11.93 | 10 | 102918 | 275 | 64395529 |
H1N1 influenza | 21.34 | 11.93 | 22 | 102906 | 2244 | 64393560 |
Blood culture positive | 21.27 | 11.93 | 42 | 102886 | 7826 | 64387978 |
Cerebellar haemangioma | 21.24 | 11.93 | 7 | 102921 | 72 | 64395732 |
Electrocardiogram QT prolonged | 21.18 | 11.93 | 61 | 102867 | 79387 | 64316417 |
Graft versus host disease | 21.14 | 11.93 | 59 | 102869 | 13754 | 64382050 |
Throat irritation | 21.14 | 11.93 | 13 | 102915 | 32698 | 64363106 |
Pulmonary oedema | 21.09 | 11.93 | 205 | 102723 | 78469 | 64317335 |
Conjunctival irritation | 21.08 | 11.93 | 8 | 102920 | 128 | 64395676 |
Neutropenic sepsis | 20.90 | 11.93 | 83 | 102845 | 23189 | 64372615 |
Toxic skin eruption | 20.84 | 11.93 | 73 | 102855 | 19211 | 64376593 |
Accidental exposure to product | 20.80 | 11.93 | 8 | 102920 | 26356 | 64369448 |
Amnesia | 20.71 | 11.93 | 28 | 102900 | 48241 | 64347563 |
JC virus infection | 20.44 | 11.93 | 26 | 102902 | 3329 | 64392475 |
Visual impairment | 20.39 | 11.93 | 56 | 102872 | 74021 | 64321783 |
Hypokalaemia | 20.37 | 11.93 | 290 | 102638 | 121613 | 64274191 |
Oropharyngeal pain | 20.36 | 11.93 | 73 | 102855 | 88794 | 64307010 |
Bronchiolitis | 20.29 | 11.93 | 27 | 102901 | 3614 | 64392190 |
Coma | 20.06 | 11.93 | 72 | 102856 | 87543 | 64308261 |
Leukaemia | 20.01 | 11.93 | 32 | 102896 | 5056 | 64390748 |
Tooth deposit | 19.98 | 11.93 | 9 | 102919 | 226 | 64395578 |
Refractory cancer | 19.94 | 11.93 | 9 | 102919 | 227 | 64395577 |
Musculoskeletal pain | 19.83 | 11.93 | 65 | 102863 | 81229 | 64314575 |
Intentional product misuse | 19.64 | 11.93 | 55 | 102873 | 72240 | 64323564 |
Sinus polyp | 19.60 | 11.93 | 11 | 102917 | 445 | 64395359 |
General physical condition abnormal | 19.56 | 11.93 | 33 | 102895 | 5449 | 64390355 |
Hallucination, visual | 19.51 | 11.93 | 10 | 102918 | 27824 | 64367980 |
Pneumonia influenzal | 19.40 | 11.93 | 22 | 102906 | 2500 | 64393304 |
Irritability | 19.39 | 11.93 | 18 | 102910 | 36728 | 64359076 |
Chromaturia | 19.32 | 11.93 | 6 | 102922 | 22605 | 64373199 |
Device dislocation | 19.25 | 11.93 | 5 | 102923 | 21173 | 64374631 |
Lung disorder | 19.24 | 11.93 | 164 | 102764 | 60536 | 64335268 |
Paraesthesia | 19.00 | 11.93 | 311 | 102617 | 134211 | 64261593 |
Extrapyramidal disorder | 18.99 | 11.93 | 4 | 102924 | 19548 | 64376256 |
Injection site bruising | 18.98 | 11.93 | 18 | 102910 | 36355 | 64359449 |
Atrial flutter | 18.94 | 11.93 | 71 | 102857 | 19309 | 64376495 |
Mantle cell lymphoma recurrent | 18.87 | 11.93 | 11 | 102917 | 479 | 64395325 |
Death | 18.82 | 11.93 | 946 | 101982 | 481759 | 63914045 |
Brief psychotic disorder with marked stressors | 18.75 | 11.93 | 9 | 102919 | 262 | 64395542 |
Adenovirus infection | 18.74 | 11.93 | 38 | 102890 | 7217 | 64388587 |
Dry mouth | 18.71 | 11.93 | 43 | 102885 | 60375 | 64335429 |
Therapeutic response decreased | 18.70 | 11.93 | 145 | 102783 | 52043 | 64343761 |
Intraductal proliferative breast lesion | 18.68 | 11.93 | 20 | 102908 | 2131 | 64393673 |
Peritonitis viral | 18.64 | 11.93 | 6 | 102922 | 57 | 64395747 |
Memory impairment | 18.58 | 11.93 | 72 | 102856 | 85610 | 64310194 |
Faeces discoloured | 18.40 | 11.93 | 9 | 102919 | 25720 | 64370084 |
Dyspepsia | 18.38 | 11.93 | 66 | 102862 | 80246 | 64315558 |
Acne | 18.21 | 11.93 | 7 | 102921 | 23074 | 64372730 |
Multiple sclerosis | 18.14 | 11.93 | 4 | 102924 | 18937 | 64376867 |
Pseudomyopia | 18.10 | 11.93 | 6 | 102922 | 63 | 64395741 |
Torsade de pointes | 18.04 | 11.93 | 3 | 102925 | 17360 | 64378444 |
Bursitis | 17.83 | 11.93 | 6 | 102922 | 21479 | 64374325 |
Malignant melanoma in situ | 17.74 | 11.93 | 18 | 102910 | 1802 | 64394002 |
Plasma cells present | 17.73 | 11.93 | 4 | 102924 | 7 | 64395797 |
Therapy interrupted | 17.70 | 11.93 | 5 | 102923 | 20031 | 64375773 |
Rash pruritic | 17.62 | 11.93 | 154 | 102774 | 57250 | 64338554 |
Light chain analysis abnormal | 17.58 | 11.93 | 7 | 102921 | 128 | 64395676 |
Disturbance in social behaviour | 17.47 | 11.93 | 26 | 102902 | 3861 | 64391943 |
Drug reaction with eosinophilia and systemic symptoms | 17.46 | 11.93 | 147 | 102781 | 54070 | 64341734 |
Injection site exfoliation | 17.29 | 11.93 | 7 | 102921 | 134 | 64395670 |
Frequent bowel movements | 17.26 | 11.93 | 4 | 102924 | 18301 | 64377503 |
Genital erythema | 17.19 | 11.93 | 8 | 102920 | 217 | 64395587 |
Bone lesion | 17.12 | 11.93 | 30 | 102898 | 5107 | 64390697 |
Hyperthyroidism | 17.09 | 11.93 | 4 | 102924 | 18175 | 64377629 |
Blood immunoglobulin M increased | 17.01 | 11.93 | 10 | 102918 | 442 | 64395362 |
Cerebral aspergillosis | 16.97 | 11.93 | 17 | 102911 | 1676 | 64394128 |
Gastric ulcer | 16.93 | 11.93 | 14 | 102914 | 30220 | 64365584 |
Multiple organ dysfunction syndrome | 16.84 | 11.93 | 241 | 102687 | 101172 | 64294632 |
Myelosuppression | 16.80 | 11.93 | 79 | 102849 | 23751 | 64372053 |
Light chain analysis | 16.77 | 11.93 | 4 | 102924 | 10 | 64395794 |
Enteric neuropathy | 16.77 | 11.93 | 4 | 102924 | 10 | 64395794 |
Joint range of motion decreased | 16.77 | 11.93 | 5 | 102923 | 19338 | 64376466 |
Plasma cells decreased | 16.75 | 11.93 | 5 | 102923 | 36 | 64395768 |
Adverse drug reaction | 16.67 | 11.93 | 127 | 102801 | 45337 | 64350467 |
Drug level increased | 16.61 | 11.93 | 18 | 102910 | 34178 | 64361626 |
Ejection fraction decreased | 16.60 | 11.93 | 90 | 102838 | 28617 | 64367187 |
Liver injury | 16.59 | 11.93 | 14 | 102914 | 29918 | 64365886 |
Joint ankylosis | 16.59 | 11.93 | 12 | 102916 | 757 | 64395047 |
Decreased appetite | 16.58 | 11.93 | 576 | 102352 | 280713 | 64115091 |
Liver function test increased | 16.54 | 11.93 | 15 | 102913 | 30955 | 64364849 |
Sleep apnoea syndrome | 16.48 | 11.93 | 14 | 102914 | 29818 | 64365986 |
Cardio-respiratory arrest | 16.40 | 11.93 | 91 | 102837 | 98302 | 64297502 |
Aphasia | 16.29 | 11.93 | 25 | 102903 | 40881 | 64354923 |
Enterococcal sepsis | 16.27 | 11.93 | 20 | 102908 | 2474 | 64393330 |
Thrombotic thrombocytopenic purpura | 16.25 | 11.93 | 32 | 102896 | 5952 | 64389852 |
Poor quality sleep | 16.25 | 11.93 | 5 | 102923 | 18946 | 64376858 |
Organising pneumonia | 16.21 | 11.93 | 41 | 102887 | 9014 | 64386790 |
Respiratory arrest | 16.17 | 11.93 | 38 | 102890 | 52947 | 64342857 |
Renal impairment | 16.15 | 11.93 | 304 | 102624 | 134713 | 64261091 |
Glycosylated haemoglobin increased | 16.14 | 11.93 | 3 | 102925 | 16016 | 64379788 |
Fear | 16.11 | 11.93 | 6 | 102922 | 20165 | 64375639 |
Infection reactivation | 16.11 | 11.93 | 18 | 102910 | 2012 | 64393792 |
Myocardial infarction | 16.08 | 11.93 | 178 | 102750 | 165643 | 64230161 |
Venous thrombosis | 15.99 | 11.93 | 33 | 102895 | 6348 | 64389456 |
Adenoviral haemorrhagic cystitis | 15.88 | 11.93 | 10 | 102918 | 501 | 64395303 |
Empyema | 15.73 | 11.93 | 24 | 102904 | 3641 | 64392163 |
Paraproteinaemia | 15.71 | 11.93 | 9 | 102919 | 379 | 64395425 |
Blood creatinine increased | 15.65 | 11.93 | 304 | 102624 | 135478 | 64260326 |
Staphylococcal bacteraemia | 15.62 | 11.93 | 44 | 102884 | 10311 | 64385493 |
Pneumonia parainfluenzae viral | 15.58 | 11.93 | 8 | 102920 | 270 | 64395534 |
Disturbance in attention | 15.51 | 11.93 | 26 | 102902 | 41048 | 64354756 |
Infection in an immunocompromised host | 15.45 | 11.93 | 13 | 102915 | 1024 | 64394780 |
Dyspnoea | 15.41 | 11.93 | 965 | 101963 | 717709 | 63678095 |
Laryngeal cancer metastatic | 15.30 | 11.93 | 5 | 102923 | 50 | 64395754 |
Cardiac failure congestive | 15.27 | 11.93 | 293 | 102635 | 130287 | 64265517 |
Plasmablastic lymphoma | 15.27 | 11.93 | 9 | 102919 | 400 | 64395404 |
Neck pain | 15.15 | 11.93 | 49 | 102879 | 61484 | 64334320 |
Hypoglossal nerve paresis | 15.11 | 11.93 | 6 | 102922 | 109 | 64395695 |
Hyperlipidaemia | 15.03 | 11.93 | 9 | 102919 | 22967 | 64372837 |
Hyperamylasaemia | 15.02 | 11.93 | 12 | 102916 | 879 | 64394925 |
Nodule | 14.92 | 11.93 | 5 | 102923 | 17942 | 64377862 |
Periodontitis | 14.79 | 11.93 | 25 | 102903 | 4134 | 64391670 |
Atelectasis | 14.77 | 11.93 | 84 | 102844 | 27182 | 64368622 |
Capillary leak syndrome | 14.74 | 11.93 | 22 | 102906 | 3275 | 64392529 |
Engraftment syndrome | 14.65 | 11.93 | 13 | 102915 | 1100 | 64394704 |
Tendonitis | 14.65 | 11.93 | 7 | 102921 | 20275 | 64375529 |
Monoclonal gammopathy | 14.64 | 11.93 | 11 | 102917 | 736 | 64395068 |
Myositis | 14.63 | 11.93 | 4 | 102924 | 16373 | 64379431 |
Immunosuppression | 14.61 | 11.93 | 44 | 102884 | 10702 | 64385102 |
Product prescribing error | 14.59 | 11.93 | 21 | 102907 | 35248 | 64360556 |
Serratia sepsis | 14.53 | 11.93 | 6 | 102922 | 121 | 64395683 |
Scrotal pain | 14.53 | 11.93 | 9 | 102919 | 438 | 64395366 |
Body temperature decreased | 14.53 | 11.93 | 12 | 102916 | 25916 | 64369888 |
Hyperkalaemia | 14.52 | 11.93 | 98 | 102830 | 101031 | 64294773 |
Squamous cell carcinoma of lung | 14.51 | 11.93 | 17 | 102911 | 2001 | 64393803 |
Acute respiratory distress syndrome | 14.41 | 11.93 | 109 | 102819 | 38826 | 64356978 |
Clostridium difficile infection | 14.39 | 11.93 | 103 | 102825 | 36060 | 64359744 |
Escherichia infection | 14.35 | 11.93 | 55 | 102873 | 15113 | 64380691 |
Tachycardia | 14.33 | 11.93 | 161 | 102767 | 149418 | 64246386 |
Cytomegalovirus enterocolitis | 14.31 | 11.93 | 14 | 102914 | 1341 | 64394463 |
Febrile bone marrow aplasia | 14.30 | 11.93 | 45 | 102883 | 11210 | 64384594 |
Cardiomegaly | 14.20 | 11.93 | 75 | 102853 | 23609 | 64372195 |
Nightmare | 14.05 | 11.93 | 8 | 102920 | 20985 | 64374819 |
Panic attack | 14.00 | 11.93 | 8 | 102920 | 20945 | 64374859 |
Bronchopulmonary aspergillosis | 13.99 | 11.93 | 64 | 102864 | 19021 | 64376783 |
Varicella | 13.94 | 11.93 | 19 | 102909 | 2602 | 64393202 |
Pneumocystis jirovecii infection | 13.92 | 11.93 | 18 | 102910 | 2343 | 64393461 |
Cardiotoxicity | 13.91 | 11.93 | 42 | 102886 | 10232 | 64385572 |
Pulmonary arterial hypertension | 13.89 | 11.93 | 12 | 102916 | 25355 | 64370449 |
Parkinsonism | 13.84 | 11.93 | 3 | 102925 | 14370 | 64381434 |
Pneumonia bacterial | 13.80 | 11.93 | 54 | 102874 | 14981 | 64380823 |
Small intestinal obstruction | 13.69 | 11.93 | 74 | 102854 | 23499 | 64372305 |
Pneumonia respiratory syncytial viral | 13.67 | 11.93 | 14 | 102914 | 1417 | 64394387 |
Haematochezia | 13.61 | 11.93 | 57 | 102871 | 66316 | 64329488 |
Cholelithiasis | 13.60 | 11.93 | 33 | 102895 | 45473 | 64350331 |
Eosinophil count increased | 13.48 | 11.93 | 3 | 102925 | 14109 | 64381695 |
Gastrointestinal amyloidosis | 13.47 | 11.93 | 5 | 102923 | 75 | 64395729 |
Procedural pain | 13.46 | 11.93 | 4 | 102924 | 15504 | 64380300 |
Delayed engraftment | 13.40 | 11.93 | 7 | 102921 | 245 | 64395559 |
Pulmonary alveolar haemorrhage | 13.36 | 11.93 | 40 | 102888 | 9698 | 64386106 |
Blood immunoglobulin A decreased | 13.33 | 11.93 | 9 | 102919 | 508 | 64395296 |
Rhinovirus infection | 13.32 | 11.93 | 30 | 102898 | 6126 | 64389678 |
Malignant neoplasm of unknown primary site | 13.23 | 11.93 | 10 | 102918 | 675 | 64395129 |
Haemorrhagic fever | 13.14 | 11.93 | 4 | 102924 | 31 | 64395773 |
Paranoid personality disorder | 13.14 | 11.93 | 4 | 102924 | 31 | 64395773 |
Prinzmetal angina | 13.10 | 11.93 | 14 | 102914 | 1489 | 64394315 |
Impaired work ability | 13.07 | 11.93 | 4 | 102924 | 15215 | 64380589 |
Transplant | 13.07 | 11.93 | 11 | 102917 | 867 | 64394937 |
Bence Jones proteinuria | 13.04 | 11.93 | 3 | 102925 | 6 | 64395798 |
Foot deformity | 13.03 | 11.93 | 5 | 102923 | 16499 | 64379305 |
Transitional cell carcinoma | 13.03 | 11.93 | 17 | 102911 | 2232 | 64393572 |
Clostridium colitis | 12.97 | 11.93 | 18 | 102910 | 2507 | 64393297 |
Feeling hot | 12.96 | 11.93 | 34 | 102894 | 45629 | 64350175 |
Blood triglycerides increased | 12.90 | 11.93 | 7 | 102921 | 18859 | 64376945 |
Therapy cessation | 12.80 | 11.93 | 20 | 102908 | 32469 | 64363335 |
Mental disorder | 12.76 | 11.93 | 14 | 102914 | 26431 | 64369373 |
Mouth ulceration | 12.76 | 11.93 | 20 | 102908 | 32424 | 64363380 |
Follicle centre lymphoma, follicular grade I, II, III recurrent | 12.73 | 11.93 | 3 | 102925 | 7 | 64395797 |
Minimal residual disease | 12.56 | 11.93 | 8 | 102920 | 409 | 64395395 |
Movement disorder | 12.55 | 11.93 | 10 | 102918 | 21990 | 64373814 |
Testicular swelling | 12.54 | 11.93 | 11 | 102917 | 917 | 64394887 |
Haemorrhoidal haemorrhage | 12.52 | 11.93 | 28 | 102900 | 5691 | 64390113 |
Hypotension | 12.51 | 11.93 | 735 | 102193 | 380239 | 64015565 |
Malnutrition | 12.47 | 11.93 | 62 | 102866 | 19063 | 64376741 |
Product storage error | 12.38 | 11.93 | 3 | 102925 | 13315 | 64382489 |
Pneumocystis jirovecii pneumonia | 12.36 | 11.93 | 81 | 102847 | 27553 | 64368251 |
Glomerular filtration rate decreased | 12.34 | 11.93 | 8 | 102920 | 19564 | 64376240 |
Encephalitis viral | 12.28 | 11.93 | 17 | 102911 | 2363 | 64393441 |
Endothelial dysfunction | 12.27 | 11.93 | 6 | 102922 | 182 | 64395622 |
Oesophageal adenocarcinoma | 12.21 | 11.93 | 10 | 102918 | 759 | 64395045 |
Chronic graft versus host disease in skin | 12.20 | 11.93 | 13 | 102915 | 1378 | 64394426 |
Adenocarcinoma pancreas | 12.19 | 11.93 | 15 | 102913 | 1858 | 64393946 |
Electrodesiccation | 12.18 | 11.93 | 3 | 102925 | 9 | 64395795 |
Cerebrovascular accident | 12.06 | 11.93 | 151 | 102777 | 137432 | 64258372 |
Varicella zoster virus infection | 12.05 | 11.93 | 22 | 102906 | 3866 | 64391938 |
Anger | 12.05 | 11.93 | 5 | 102923 | 15736 | 64380068 |
None
Source | Code | Description |
---|---|---|
ATC | L01XG01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Proteasome inhibitors |
FDA MoA | N0000175075 | Proteasome Inhibitors |
FDA EPC | N0000175604 | Proteasome Inhibitor |
MeSH PA | D000970 | Antineoplastic Agents |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
CHEBI has role | CHEBI:37670 | protease inhibitors |
CHEBI has role | CHEBI:52726 | proteasome inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Systemic AL amyloidosis | indication | 23132008 | |
Multiple myeloma | indication | 109989006 | DOID:9538 |
Mantle cell lymphoma | indication | 443487006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Interstitial pneumonia | contraindication | 64667001 | |
Adult respiratory distress syndrome | contraindication | 67782005 | DOID:11394 |
Pulmonary hypertension | contraindication | 70995007 | DOID:6432 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Intestinal obstruction | contraindication | 81060008 | DOID:8437 |
Prolonged QT interval | contraindication | 111975006 | |
Pneumonia | contraindication | 233604007 | DOID:552 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Breastfeeding (mother) | contraindication | 413712001 | |
Posterior reversible encephalopathy syndrome | contraindication | 450886002 | |
Chemotherapy-Induced Hyperuricemia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.39 | acidic |
pKa2 | 12.09 | acidic |
pKa3 | 13.65 | acidic |
pKa4 | 2.9 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
3.5MG/VIAL | VELCADE | TAKEDA PHARMS USA | N021602 | May 13, 2003 | RX | INJECTABLE | INTRAVENOUS, SUBCUTANEOUS | April 8, 2022 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Proteasome subunit beta type-5 | Enzyme | INHIBITOR | Ki | 9.26 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-8 | Enzyme | INHIBITOR | IC50 | 8.09 | CHEMBL | CHEMBL | |||
Proteasome subunit alpha type-1 | Enzyme | INHIBITOR | Ki | 9.21 | WOMBAT-PK | CHEMBL | |||
Proteasome subunit beta type-1 | Enzyme | INHIBITOR | IC50 | 7.28 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-2 | Enzyme | INHIBITOR | IC50 | 6.23 | CHEMBL | CHEMBL | |||
Prothrombin | Enzyme | Ki | 4.89 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.16 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.17 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | Ki | 4.75 | WOMBAT-PK | |||||
26S proteasome non-ATPase regulatory subunit 1 | Cytosolic other | Ki | 7.75 | WOMBAT-PK | |||||
Histone deacetylase 2 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
Histone deacetylase 1 | Enzyme | IC50 | 6.21 | CHEMBL | |||||
Histone deacetylase 3 | Enzyme | IC50 | 5.93 | CHEMBL | |||||
Histone deacetylase 6 | Enzyme | IC50 | 4.16 | CHEMBL | |||||
Neutrophil elastase | Enzyme | Ki | 5.64 | CHEMBL | |||||
Carbonic anhydrase 3 | Enzyme | Ki | 5.34 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 5.36 | CHEMBL | |||||
Histone deacetylase 8 | Enzyme | IC50 | 7.14 | CHEMBL | |||||
Cathepsin G | Enzyme | Ki | 6.20 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.48 | CHEMBL | |||||
Chymase | Enzyme | IC50 | 5.92 | CHEMBL | |||||
Chymotrypsinogen B | Enzyme | Ki | 6.49 | CHEMBL | |||||
Lysosomal protective protein | Enzyme | IC50 | 5.04 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 5.07 | CHEMBL | |||||
PH and SEC7 domain-containing protein 1 | Unclassified | Ki | 7.75 | WOMBAT-PK | |||||
Nuclear factor NF-kappa-B complex | Transcription factor | IC50 | 8.01 | CHEMBL | |||||
Proteasome subunit beta type-9 | Enzyme | IC50 | 8.52 | CHEMBL | |||||
Proteasome subunit beta type-10 | Enzyme | IC50 | 6.03 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 5.94 | CHEMBL | |||||
Carbonic anhydrase 1 | Enzyme | Ki | 5.89 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 5.19 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 5.47 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 5.23 | CHEMBL | |||||
Carbonic anhydrase 15 | Enzyme | Ki | 5.57 | CHEMBL | |||||
Beta-carbonic anhydrase 1 | Enzyme | Ki | 5.14 | CHEMBL | |||||
Alpha-chymotrypsin | Enzyme | Ki | 5.62 | CHEMBL | |||||
Proteasome subunit beta | Enzyme | IC50 | 7.51 | IUPHAR | |||||
Proteasome subunit beta type-8 | Enzyme | IC50 | 7.78 | CHEMBL | |||||
ATP-dependent Clp protease proteolytic subunit | Enzyme | IC50 | 5.28 | CHEMBL |
ID | Source |
---|---|
4021393 | VUID |
N0000148811 | NUI |
D03150 | KEGG_DRUG |
356733 | RXNORM |
C1176309 | UMLSCUI |
CHEBI:52717 | CHEBI |
BO2 | PDB_CHEM_ID |
CHEMBL325041 | ChEMBL_ID |
DB00188 | DRUGBANK_ID |
D000069286 | MESH_DESCRIPTOR_UI |
387447 | PUBCHEM_CID |
6391 | IUPHAR_LIGAND_ID |
8331 | INN_ID |
69G8BD63PP | UNII |
17263 | MMSL |
233935 | MMSL |
46756 | MMSL |
d04871 | MMSL |
009985 | NDDF |
398907002 | SNOMEDCT_US |
407097007 | SNOMEDCT_US |
4021393 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1703 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2.50 mg | INTRAVENOUS | NDA | 33 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1704 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 33 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-244 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-865 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 26 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-484 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51817-586 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 32 sections |
BORTEZOMIB | Human Prescription Drug Label | 1 | 55150-337 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6050 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-821 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 30 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67184-0530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-540 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-1411 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1708 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 2 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70860-225 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |