sulfadicramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 3560 115-68-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfadicramide
  • sulfanildimethylacryloylamide
  • sulfauridin
  • sulfirgamid
  • sulfirgamide
  • Molecular weight: 254.30
  • Formula: C11H14N2O3S
  • CLOGP: 0.40
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 89.26
  • ALOGS: -2.32
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.684 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.786 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 17.179 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 3.690 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 20.560 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 25.350 % Moderate 0.67
herg hERG pIC50 3.833 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 2.472 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.266 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 14.750 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 60
kinase-selectivity-class ACVR2A,AURKA,AXL,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MAP2K6,MAP3K7,MAPK7,MARK4,PDK2,SIK2,STK33,SYK,TEK,TTK,ULK1 20
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.041 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 7.798 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 33.490 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.104 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 16.630 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 2.911 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.480 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 10.320 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 944.061 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01AB03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Sulfonamides
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

S01AB Sulfonamides 4 drugs
sulfacetamidesulfafurazolesulfamethizolesulfaphenazole

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.63 acidic
pKa2 1.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07412 KEGG_DRUG
C3652541 UMLSCUI
CHEBI:135039 CHEBI
CHEMBL2104910 ChEMBL_ID
DB13214 DRUGBANK_ID
8281 PUBCHEM_CID
314 INN_ID
7WZ5EG263C UNII

Pharmaceutical products:

None