phenoperidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analgesics, pethidine derivatives and other synthetic small molecule miu-opioid receptor agonists | 3441 | 562-26-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 5.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 22 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.22 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N01AH04 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Opioid anesthetics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167337 | NUI |
| D02611 | KEGG_DRUG |
| C0031432 | UMLSCUI |
| CHEBI:135550 | CHEBI |
| CHEMBL2105385 | ChEMBL_ID |
| DB13605 | DRUGBANK_ID |
| D010638 | MESH_DESCRIPTOR_UI |
| 11226 | PUBCHEM_CID |
| 1062 | INN_ID |
| 3627-49-4 | SECONDARY_CAS_RN |
| G9BH09J4JW | UNII |
| 106508 | RXNORM |
| 004020 | NDDF |
| 004021 | NDDF |
| 350306009 | SNOMEDCT_US |
| 420076001 | SNOMEDCT_US |
Pharmaceutical products:
None