Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor agonists, analgesics, fentanyl derivatives | 2491 | 56030-54-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 6 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.06 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 9.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 15 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 14 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 25, 2018 | EMA | LABORATOIRE AGUETTANT | |
May 4, 1984 | FDA | AKORN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 1777.17 | 29.56 | 430 | 6640 | 23203 | 63458749 |
Hypotension | 326.01 | 29.56 | 257 | 6813 | 272347 | 63209605 |
Bronchospasm | 270.17 | 29.56 | 93 | 6977 | 17187 | 63464765 |
Anaphylactic reaction | 231.68 | 29.56 | 123 | 6947 | 65977 | 63415975 |
Maternal exposure during delivery | 179.42 | 29.56 | 40 | 7030 | 1460 | 63480492 |
Exposure during pregnancy | 156.38 | 29.56 | 133 | 6937 | 155414 | 63326538 |
Cardiac arrest | 142.72 | 29.56 | 102 | 6968 | 92443 | 63389509 |
Anaphylactoid shock | 111.94 | 29.56 | 21 | 7049 | 316 | 63481636 |
Circulatory collapse | 106.58 | 29.56 | 51 | 7019 | 21887 | 63460065 |
Tachycardia | 106.44 | 29.56 | 95 | 6975 | 118061 | 63363891 |
Type I hypersensitivity | 105.90 | 29.56 | 30 | 7040 | 2912 | 63479040 |
Acute generalised exanthematous pustulosis | 100.42 | 29.56 | 40 | 7030 | 11059 | 63470893 |
Allergy test negative | 95.55 | 29.56 | 17 | 7053 | 187 | 63481765 |
Cardio-respiratory arrest | 92.13 | 29.56 | 66 | 7004 | 59893 | 63422059 |
Mixed liver injury | 87.80 | 29.56 | 29 | 7041 | 4706 | 63477246 |
Shock | 85.82 | 29.56 | 45 | 7025 | 23418 | 63458534 |
Respiratory depression | 76.22 | 29.56 | 35 | 7035 | 13680 | 63468272 |
Oliguria | 76.12 | 29.56 | 31 | 7039 | 9070 | 63472882 |
Eosinophilia | 75.77 | 29.56 | 41 | 7029 | 22715 | 63459237 |
Multiple organ dysfunction syndrome | 74.87 | 29.56 | 57 | 7013 | 56695 | 63425257 |
Bradycardia | 74.18 | 29.56 | 63 | 7007 | 73164 | 63408788 |
Fatigue | 71.36 | 29.56 | 8 | 7062 | 888020 | 62593932 |
Hepatocellular injury | 71.32 | 29.56 | 42 | 7028 | 27339 | 63454613 |
Drug reaction with eosinophilia and systemic symptoms | 70.50 | 29.56 | 45 | 7025 | 33791 | 63448161 |
Haemodynamic instability | 69.06 | 29.56 | 29 | 7041 | 9161 | 63472791 |
Delayed recovery from anaesthesia | 67.75 | 29.56 | 16 | 7054 | 755 | 63481197 |
Myoclonus | 65.43 | 29.56 | 33 | 7037 | 15835 | 63466117 |
Rash maculo-papular | 65.41 | 29.56 | 42 | 7028 | 31854 | 63450098 |
Ventricular fibrillation | 65.05 | 29.56 | 30 | 7040 | 11837 | 63470115 |
Stress cardiomyopathy | 64.98 | 29.56 | 28 | 7042 | 9422 | 63472530 |
Hepatorenal failure | 64.12 | 29.56 | 15 | 7055 | 679 | 63481273 |
Toxic epidermal necrolysis | 63.73 | 29.56 | 38 | 7032 | 25296 | 63456656 |
Peripheral nerve injury | 59.29 | 29.56 | 13 | 7057 | 438 | 63481514 |
Anticholinergic syndrome | 58.20 | 29.56 | 18 | 7052 | 2364 | 63479588 |
Spinal epidural haemorrhage | 57.07 | 29.56 | 10 | 7060 | 100 | 63481852 |
Suspected product quality issue | 55.96 | 29.56 | 11 | 7059 | 214 | 63481738 |
Hypocapnia | 55.48 | 29.56 | 12 | 7058 | 379 | 63481573 |
Serotonin syndrome | 52.06 | 29.56 | 35 | 7035 | 28647 | 63453305 |
Unwanted awareness during anaesthesia | 51.50 | 29.56 | 11 | 7059 | 327 | 63481625 |
Carcinoid crisis | 48.26 | 29.56 | 10 | 7060 | 256 | 63481696 |
Oxygen saturation decreased | 47.80 | 29.56 | 54 | 7016 | 88531 | 63393421 |
Erythema | 46.91 | 29.56 | 76 | 6994 | 175675 | 63306277 |
Vasoplegia syndrome | 46.46 | 29.56 | 14 | 7056 | 1685 | 63480267 |
Patent ductus arteriosus | 44.38 | 29.56 | 17 | 7053 | 4233 | 63477719 |
Metabolic acidosis | 44.02 | 29.56 | 38 | 7032 | 45031 | 63436921 |
Spinal epidural haematoma | 42.86 | 29.56 | 12 | 7058 | 1115 | 63480837 |
Stevens-Johnson syndrome | 41.85 | 29.56 | 29 | 7041 | 24921 | 63457031 |
Myoglobin blood increased | 40.25 | 29.56 | 12 | 7058 | 1393 | 63480559 |
Cholestasis | 39.75 | 29.56 | 30 | 7040 | 29404 | 63452548 |
Hyperlactacidaemia | 39.35 | 29.56 | 14 | 7056 | 2835 | 63479117 |
Paralysis | 39.09 | 29.56 | 20 | 7050 | 9880 | 63472072 |
Dermatitis bullous | 38.94 | 29.56 | 19 | 7051 | 8489 | 63473463 |
Mydriasis | 38.28 | 29.56 | 21 | 7049 | 11935 | 63470017 |
Diarrhoea | 38.27 | 29.56 | 16 | 7054 | 715350 | 62766602 |
Uterine hypotonus | 37.20 | 29.56 | 7 | 7063 | 107 | 63481845 |
Epidural haemorrhage | 36.45 | 29.56 | 7 | 7063 | 120 | 63481832 |
Anaesthetic complication | 36.31 | 29.56 | 12 | 7058 | 1948 | 63480004 |
Postpartum haemorrhage | 36.19 | 29.56 | 12 | 7058 | 1969 | 63479983 |
Torsade de pointes | 36.12 | 29.56 | 21 | 7049 | 13330 | 63468622 |
Generalised tonic-clonic seizure | 35.74 | 29.56 | 28 | 7042 | 28988 | 63452964 |
Sinus tachycardia | 35.60 | 29.56 | 26 | 7044 | 24242 | 63457710 |
Cauda equina syndrome | 35.07 | 29.56 | 10 | 7060 | 992 | 63480960 |
Hyperthermia | 34.72 | 29.56 | 18 | 7052 | 9138 | 63472814 |
Post procedural stroke | 34.71 | 29.56 | 6 | 7064 | 55 | 63481897 |
Altered state of consciousness | 34.70 | 29.56 | 26 | 7044 | 25204 | 63456748 |
Acute pulmonary oedema | 33.72 | 29.56 | 17 | 7053 | 8141 | 63473811 |
Posterior reversible encephalopathy syndrome | 33.48 | 29.56 | 22 | 7048 | 17323 | 63464629 |
Foetal exposure during pregnancy | 33.36 | 29.56 | 28 | 7042 | 31934 | 63450018 |
Reversal of opiate activity | 32.41 | 29.56 | 4 | 7066 | 0 | 63481952 |
Premature baby | 32.21 | 29.56 | 23 | 7047 | 20712 | 63461240 |
Foetal growth restriction | 31.99 | 29.56 | 16 | 7054 | 7537 | 63474415 |
Suspected product contamination | 31.56 | 29.56 | 5 | 7065 | 25 | 63481927 |
Angioedema | 30.68 | 29.56 | 32 | 7038 | 47933 | 63434019 |
Cardiogenic shock | 30.43 | 29.56 | 21 | 7049 | 17911 | 63464041 |
Haemodilution | 30.04 | 29.56 | 6 | 7064 | 127 | 63481825 |
Foetal heart rate abnormal | 29.88 | 29.56 | 8 | 7062 | 629 | 63481323 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 1151.54 | 30.58 | 300 | 5101 | 15641 | 34935889 |
Bronchospasm | 190.35 | 30.58 | 69 | 5332 | 10662 | 34940868 |
Hyperthermia malignant | 180.77 | 30.58 | 46 | 5355 | 2131 | 34949399 |
Hypotension | 136.73 | 30.58 | 169 | 5232 | 221480 | 34730050 |
Anaphylactic reaction | 133.69 | 30.58 | 75 | 5326 | 32226 | 34919304 |
Hypertransaminasaemia | 114.31 | 30.58 | 40 | 5361 | 5566 | 34945964 |
Toxic epidermal necrolysis | 111.11 | 30.58 | 58 | 5343 | 21588 | 34929942 |
Rash maculo-papular | 109.45 | 30.58 | 63 | 5338 | 28388 | 34923142 |
Tachycardia | 101.02 | 30.58 | 92 | 5309 | 84680 | 34866850 |
Eosinophilia | 84.98 | 30.58 | 52 | 5349 | 26170 | 34925360 |
Circulatory collapse | 84.67 | 30.58 | 48 | 5353 | 20990 | 34930540 |
Drug reaction with eosinophilia and systemic symptoms | 83.52 | 30.58 | 56 | 5345 | 32956 | 34918574 |
Cholestasis | 71.25 | 30.58 | 47 | 5354 | 26901 | 34924629 |
Haemodynamic instability | 71.20 | 30.58 | 33 | 5368 | 9490 | 34942040 |
Erythema | 64.78 | 30.58 | 74 | 5327 | 88706 | 34862824 |
Shock | 61.09 | 30.58 | 41 | 5360 | 24138 | 34927392 |
Rhabdomyolysis | 60.48 | 30.58 | 63 | 5338 | 68100 | 34883430 |
Type I hypersensitivity | 58.18 | 30.58 | 17 | 5384 | 1322 | 34950208 |
Septic shock | 56.00 | 30.58 | 62 | 5339 | 71772 | 34879758 |
Hepatic cytolysis | 52.77 | 30.58 | 31 | 5370 | 14465 | 34937065 |
Injury | 52.06 | 30.58 | 35 | 5366 | 20652 | 34930878 |
Allergy test negative | 52.06 | 30.58 | 10 | 5391 | 121 | 34951409 |
Rash morbilliform | 47.86 | 30.58 | 18 | 5383 | 3069 | 34948461 |
Delayed recovery from anaesthesia | 47.65 | 30.58 | 13 | 5388 | 788 | 34950742 |
Cardiac arrest | 47.52 | 30.58 | 66 | 5335 | 96093 | 34855437 |
Hepatorenal failure | 47.16 | 30.58 | 12 | 5389 | 554 | 34950976 |
Victim of crime | 46.55 | 30.58 | 11 | 5390 | 372 | 34951158 |
Anaphylactoid shock | 46.41 | 30.58 | 11 | 5390 | 377 | 34951153 |
Multiple organ dysfunction syndrome | 44.65 | 30.58 | 57 | 5344 | 76509 | 34875021 |
Stress cardiomyopathy | 43.14 | 30.58 | 15 | 5386 | 2044 | 34949486 |
Hepatocellular injury | 42.95 | 30.58 | 32 | 5369 | 22179 | 34929351 |
Patent ductus arteriosus | 39.42 | 30.58 | 16 | 5385 | 3338 | 34948192 |
Mixed liver injury | 38.27 | 30.58 | 15 | 5386 | 2858 | 34948672 |
Suspected product quality issue | 38.12 | 30.58 | 8 | 5393 | 155 | 34951375 |
Suspected product contamination | 37.39 | 30.58 | 7 | 5394 | 73 | 34951457 |
Infantile apnoea | 36.52 | 30.58 | 11 | 5390 | 950 | 34950580 |
Post procedural haemorrhage | 36.28 | 30.58 | 20 | 5381 | 8269 | 34943261 |
Coma | 34.82 | 30.58 | 39 | 5362 | 45639 | 34905891 |
Fear | 34.48 | 30.58 | 21 | 5380 | 10455 | 34941075 |
Bradycardia | 33.16 | 30.58 | 49 | 5352 | 75369 | 34876161 |
Fibrinolysis increased | 32.76 | 30.58 | 5 | 5396 | 12 | 34951518 |
Symmetrical drug-related intertriginous and flexural exanthema | 31.88 | 30.58 | 8 | 5393 | 349 | 34951181 |
Acute generalised exanthematous pustulosis | 31.46 | 30.58 | 17 | 5384 | 6759 | 34944771 |
Agitation neonatal | 30.96 | 30.58 | 10 | 5391 | 1086 | 34950444 |
Diarrhoea | 30.76 | 30.58 | 11 | 5390 | 389901 | 34561629 |
Anaesthetic complication | 30.75 | 30.58 | 10 | 5391 | 1110 | 34950420 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 2865.51 | 27.40 | 723 | 10912 | 35273 | 79697480 |
Bronchospasm | 446.77 | 27.40 | 159 | 11476 | 24700 | 79708053 |
Anaphylactic reaction | 361.61 | 27.40 | 196 | 11439 | 83547 | 79649206 |
Hypotension | 318.04 | 27.40 | 354 | 11281 | 439963 | 79292790 |
Tachycardia | 199.59 | 27.40 | 182 | 11453 | 177586 | 79555167 |
Hyperthermia malignant | 193.63 | 27.40 | 51 | 11584 | 2866 | 79729887 |
Circulatory collapse | 175.89 | 27.40 | 93 | 11542 | 37575 | 79695178 |
Cardiac arrest | 169.71 | 27.40 | 164 | 11471 | 171932 | 79560821 |
Maternal exposure during delivery | 167.62 | 27.40 | 39 | 11596 | 1307 | 79731446 |
Type I hypersensitivity | 155.54 | 27.40 | 47 | 11588 | 4351 | 79728402 |
Toxic epidermal necrolysis | 153.26 | 27.40 | 90 | 11545 | 44491 | 79688262 |
Rash maculo-papular | 148.91 | 27.40 | 96 | 11539 | 55982 | 79676771 |
Drug reaction with eosinophilia and systemic symptoms | 148.84 | 27.40 | 101 | 11534 | 64143 | 79668610 |
Anaphylactoid shock | 142.94 | 27.40 | 31 | 11604 | 750 | 79732003 |
Eosinophilia | 138.90 | 27.40 | 85 | 11550 | 45260 | 79687493 |
Allergy test negative | 137.35 | 27.40 | 26 | 11609 | 308 | 79732445 |
Shock | 136.90 | 27.40 | 83 | 11552 | 43465 | 79689288 |
Acute generalised exanthematous pustulosis | 120.36 | 27.40 | 56 | 11579 | 17198 | 79715555 |
Mixed liver injury | 111.94 | 27.40 | 42 | 11593 | 7536 | 79725217 |
Delayed recovery from anaesthesia | 109.83 | 27.40 | 29 | 11606 | 1644 | 79731109 |
Hypertransaminasaemia | 109.76 | 27.40 | 47 | 11588 | 11877 | 79720876 |
Hepatorenal failure | 107.41 | 27.40 | 27 | 11608 | 1258 | 79731495 |
Erythema | 106.13 | 27.40 | 146 | 11489 | 223144 | 79509609 |
Haemodynamic instability | 104.70 | 27.40 | 51 | 11584 | 17331 | 79715422 |
Cholestasis | 104.47 | 27.40 | 75 | 11560 | 52034 | 79680719 |
Hepatocellular injury | 103.52 | 27.40 | 72 | 11563 | 47521 | 79685232 |
Fatigue | 100.26 | 27.40 | 10 | 11625 | 929717 | 78803036 |
Stress cardiomyopathy | 99.45 | 27.40 | 43 | 11592 | 11123 | 79721630 |
Multiple organ dysfunction syndrome | 98.95 | 27.40 | 104 | 11531 | 120142 | 79612611 |
Suspected product quality issue | 95.41 | 27.40 | 19 | 11616 | 298 | 79732455 |
Cardio-respiratory arrest | 82.47 | 27.40 | 90 | 11545 | 108420 | 79624333 |
Respiratory depression | 80.02 | 27.40 | 50 | 11585 | 27580 | 79705173 |
Bradycardia | 77.28 | 27.40 | 97 | 11538 | 135460 | 79597293 |
Oliguria | 72.51 | 27.40 | 39 | 11596 | 16270 | 79716483 |
Suspected product contamination | 68.10 | 27.40 | 12 | 11623 | 92 | 79732661 |
Septic shock | 67.02 | 27.40 | 86 | 11549 | 122715 | 79610038 |
Rash morbilliform | 65.84 | 27.40 | 27 | 11608 | 6123 | 79726630 |
Rhabdomyolysis | 65.57 | 27.40 | 78 | 11557 | 103053 | 79629700 |
Anaesthetic complication | 61.73 | 27.40 | 21 | 11614 | 2838 | 79729915 |
Diarrhoea | 59.80 | 27.40 | 27 | 11608 | 880462 | 78852291 |
Carcinoid crisis | 59.05 | 27.40 | 14 | 11621 | 509 | 79732244 |
Hepatic cytolysis | 56.51 | 27.40 | 40 | 11595 | 27111 | 79705642 |
Myoclonus | 55.84 | 27.40 | 40 | 11595 | 27620 | 79705133 |
Acute pulmonary oedema | 54.92 | 27.40 | 31 | 11604 | 14199 | 79718554 |
Dizziness | 53.25 | 27.40 | 7 | 11628 | 526434 | 79206319 |
Torsade de pointes | 51.06 | 27.40 | 33 | 11602 | 19279 | 79713474 |
Peripheral nerve injury | 49.86 | 27.40 | 13 | 11622 | 701 | 79732052 |
Vasoplegia syndrome | 49.57 | 27.40 | 19 | 11616 | 3611 | 79729142 |
Dermatitis bullous | 49.55 | 27.40 | 29 | 11606 | 14216 | 79718537 |
Unwanted awareness during anaesthesia | 48.93 | 27.40 | 11 | 11624 | 315 | 79732438 |
Symmetrical drug-related intertriginous and flexural exanthema | 47.08 | 27.40 | 13 | 11622 | 873 | 79731880 |
Ventricular fibrillation | 46.47 | 27.40 | 38 | 11597 | 31888 | 79700865 |
Hypocapnia | 46.32 | 27.40 | 12 | 11623 | 631 | 79732122 |
Anticholinergic syndrome | 46.10 | 27.40 | 18 | 11617 | 3593 | 79729160 |
Headache | 45.98 | 27.40 | 19 | 11616 | 653753 | 79079000 |
Spinal epidural haemorrhage | 44.96 | 27.40 | 9 | 11626 | 145 | 79732608 |
Exposure during pregnancy | 44.77 | 27.40 | 64 | 11571 | 101068 | 79631685 |
Victim of crime | 44.52 | 27.40 | 11 | 11624 | 477 | 79732276 |
Fibrinolysis increased | 44.20 | 27.40 | 7 | 11628 | 25 | 79732728 |
Coma | 43.53 | 27.40 | 63 | 11572 | 100586 | 79632167 |
Altered state of consciousness | 43.51 | 27.40 | 42 | 11593 | 43780 | 79688973 |
Neuromuscular block prolonged | 40.72 | 27.40 | 12 | 11623 | 1018 | 79731735 |
Fall | 39.77 | 27.40 | 11 | 11624 | 487618 | 79245135 |
Oxygen saturation decreased | 39.55 | 27.40 | 69 | 11566 | 128978 | 79603775 |
Respiratory acidosis | 39.48 | 27.40 | 23 | 11612 | 11177 | 79721576 |
Ventricular tachycardia | 39.40 | 27.40 | 39 | 11596 | 41896 | 79690857 |
Nervous system disorder | 39.15 | 27.40 | 32 | 11603 | 26824 | 79705929 |
Hyperlactacidaemia | 38.51 | 27.40 | 18 | 11617 | 5577 | 79727176 |
Fear | 38.09 | 27.40 | 29 | 11606 | 21957 | 79710796 |
Arthralgia | 38.01 | 27.40 | 18 | 11617 | 571785 | 79160968 |
Acute respiratory distress syndrome | 37.78 | 27.40 | 39 | 11596 | 44028 | 79688725 |
Cardiogenic shock | 37.58 | 27.40 | 38 | 11597 | 41876 | 79690877 |
Uterine hypotonus | 36.97 | 27.40 | 7 | 11628 | 83 | 79732670 |
Spinal epidural haematoma | 36.82 | 27.40 | 12 | 11623 | 1420 | 79731333 |
Anaesthetic complication neurological | 36.77 | 27.40 | 10 | 11625 | 634 | 79732119 |
Postpartum haemorrhage | 35.55 | 27.40 | 12 | 11623 | 1583 | 79731170 |
Tonic clonic movements | 35.08 | 27.40 | 13 | 11622 | 2251 | 79730502 |
Malaise | 34.79 | 27.40 | 14 | 11621 | 489855 | 79242898 |
Metabolic acidosis | 33.29 | 27.40 | 50 | 11585 | 82479 | 79650274 |
Renal injury | 33.07 | 27.40 | 24 | 11611 | 16903 | 79715850 |
Cauda equina syndrome | 33.04 | 27.40 | 11 | 11624 | 1392 | 79731361 |
Anaphylactoid reaction | 32.91 | 27.40 | 16 | 11619 | 5406 | 79727347 |
Haemodilution | 32.86 | 27.40 | 7 | 11628 | 155 | 79732598 |
Device issue | 32.76 | 27.40 | 29 | 11606 | 27079 | 79705674 |
Mydriasis | 32.17 | 27.40 | 24 | 11611 | 17619 | 79715134 |
Urticaria | 31.82 | 27.40 | 78 | 11557 | 185123 | 79547630 |
Foetal heart rate abnormal | 31.75 | 27.40 | 8 | 11627 | 376 | 79732377 |
Hyperdynamic left ventricle | 31.37 | 27.40 | 8 | 11627 | 395 | 79732358 |
Leukocytosis | 31.17 | 27.40 | 35 | 11600 | 43420 | 79689333 |
Weight decreased | 30.90 | 27.40 | 7 | 11628 | 355191 | 79377562 |
Epidural haemorrhage | 30.54 | 27.40 | 7 | 11628 | 219 | 79732534 |
Weight increased | 29.73 | 27.40 | 3 | 11632 | 277383 | 79455370 |
Post procedural stroke | 29.35 | 27.40 | 6 | 11629 | 108 | 79732645 |
Angioedema | 29.16 | 27.40 | 45 | 11590 | 75990 | 79656763 |
Cough | 28.56 | 27.40 | 9 | 11626 | 366780 | 79365973 |
Nausea | 28.40 | 27.40 | 61 | 11574 | 957135 | 78775618 |
Post procedural haemorrhage | 28.02 | 27.40 | 20 | 11615 | 13724 | 79719029 |
Hypercapnia | 27.97 | 27.40 | 17 | 11618 | 8918 | 79723835 |
Third stage postpartum haemorrhage | 27.67 | 27.40 | 4 | 11631 | 6 | 79732747 |
Myoglobin blood increased | 27.61 | 27.40 | 12 | 11623 | 3139 | 79729614 |
None
Source | Code | Description |
---|---|---|
ATC | N01AH03 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Opioid anesthetics |
CHEBI has role | CHEBI:35482 | narcotic analgesic |
CHEBI has role | CHEBI:38877 | intravenous anesthetics |
CHEBI has role | CHEBI:55322 | mu-opioid agonists |
CHEBI has role | CHEBI:60807 | anaesthestic adjuvant |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000759 | Adjuvants, Anesthesia |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D018686 | Anesthetics, Intravenous |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
General anesthesia | indication | 50697003 | |
Postoperative pain | indication | 213299007 | |
Asthenia | contraindication | 13791008 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Decreased cardiac function | contraindication | 43650005 | |
Bradycardia | contraindication | 48867003 | |
Injury of head | contraindication | 82271004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.37 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 10245228 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 10507180 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8226978 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8535714 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8778393 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8778394 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8865211 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 9320710 | Jan. 5, 2027 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8202535 | Oct. 22, 2030 | TREATMENT OF ACUTE PAIN |
EQ 0.03MG BASE | DSUVIA | VERTICAL PHARMS | N209128 | Nov. 2, 2018 | RX | TABLET | SUBLINGUAL | 8865743 | Oct. 22, 2030 | TREATMENT OF ACUTE PAIN |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | EC50 | 8.13 | WOMBAT-PK | CHEMBL | |||
Kappa-type opioid receptor | GPCR | EC50 | 6.70 | WOMBAT-PK | |||||
Delta-type opioid receptor | GPCR | Ki | 7.30 | PDSP | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.71 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.66 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane other | IC50 | 5.68 | CHEMBL | |||||
Opioid receptor | GPCR | Ki | 10.70 | CHEMBL |
ID | Source |
---|---|
4019936 | VUID |
N0000148021 | NUI |
D00845 | KEGG_DRUG |
60561-17-3 | SECONDARY_CAS_RN |
4019269 | VANDF |
4019936 | VANDF |
C0143993 | UMLSCUI |
CHEBI:9316 | CHEBI |
CHEMBL658 | ChEMBL_ID |
DB00708 | DRUGBANK_ID |
CHEMBL1201163 | ChEMBL_ID |
D017409 | MESH_DESCRIPTOR_UI |
41693 | PUBCHEM_CID |
3534 | IUPHAR_LIGAND_ID |
4048 | INN_ID |
AFE2YW0IIZ | UNII |
56795 | RXNORM |
10199 | MMSL |
32203 | MMSL |
5519 | MMSL |
d00378 | MMSL |
001570 | NDDF |
004630 | NDDF |
370275005 | SNOMEDCT_US |
37527009 | SNOMEDCT_US |
49998007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3382 | INJECTION, SOLUTION | 50 ug | EPIDURAL | ANDA | 33 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3382 | INJECTION, SOLUTION | 50 ug | EPIDURAL | ANDA | 33 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6110 | INJECTION | 0.05 mg | EPIDURAL | ANDA | 27 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6111 | INJECTION | 0.05 mg | EPIDURAL | ANDA | 27 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6112 | INJECTION | 0.05 mg | EPIDURAL | ANDA | 27 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-050 | INJECTION | 50 ug | INTRAVENOUS | NDA | 29 sections |
Sufentanil Citrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-050 | INJECTION | 50 ug | INTRAVENOUS | NDA | 29 sections |
Dsuvia | Human Prescription Drug Label | 1 | 61621-430 | TABLET | 30 ug | SUBLINGUAL | NDA | 30 sections |