fentanyl Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor agonists, analgesics, fentanyl derivatives 1164 437-38-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fentanyl
  • fentanil
  • fentanyl citrate
  • effentora
  • instanyl
  • fentanyl hydrochloride
  • fentanyl HCl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance.
  • Molecular weight: 336.48
  • Formula: C22H28N2O
  • CLOGP: 3.62
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.15
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.60 mg N
0.60 mg SL
1.20 mg TD

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 25 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.89 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.16 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 19, 1968 FDA AKORN
June 29, 2020 PMDA Hisamitsu Pharmaceutical Co., Inc.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1810.61 9.93 1409 117552 61999 46505102
Toxicity to various agents 799.62 9.93 1703 117258 210063 46357038
Product adhesion issue 557.60 9.93 266 118695 4689 46562412
Respiratory arrest 478.43 9.93 507 118454 33309 46533792
Respiratory depression 469.76 9.93 319 118642 11281 46555820
Serotonin syndrome 441.95 9.93 417 118544 23803 46543298
Cardiac arrest 415.30 9.93 790 118171 89609 46477492
Death 404.81 9.93 1808 117153 333740 46233361
Inadequate analgesia 403.61 9.93 179 118782 2645 46564456
Cardio-respiratory arrest 345.25 9.93 578 118383 59291 46507810
Product quality issue 342.39 9.93 438 118523 35210 46531891
Incorrect route of product administration 291.08 9.93 278 118683 16105 46550996
Drug withdrawal syndrome 281.30 9.93 348 118613 27036 46540065
Overdose 275.55 9.93 721 118240 101258 46465843
Product prescribing error 270.12 9.93 293 118668 19754 46547347
Accidental overdose 240.69 9.93 276 118685 19790 46547311
Anaphylactic reaction 237.35 9.93 459 118502 52653 46514448
Intentional product misuse 223.82 9.93 418 118543 46710 46520391
Product complaint 218.11 9.93 207 118754 11894 46555207
Wrong technique in product usage process 203.64 9.93 437 118524 53985 46513116
Maternal exposure during delivery 174.74 9.93 69 118892 747 46566354
Anaesthetic complication 172.86 9.93 87 118874 1730 46565371
Apnoea 172.81 9.93 146 118815 7193 46559908
Drug interaction 171.30 9.93 991 117970 202103 46364998
Rheumatoid arthritis 158.57 9.93 229 118732 239986 46327115
Alopecia 153.25 9.93 114 118847 162300 46404801
Bradycardia 152.36 9.93 442 118519 65856 46501245
Unresponsive to stimuli 151.02 9.93 284 118677 31890 46535211
Delayed recovery from anaesthesia 150.73 9.93 63 118898 798 46566303
Drug dependence 146.40 9.93 215 118746 19686 46547415
Cough 144.69 9.93 227 118734 230022 46337079
Accidental exposure to product by child 137.76 9.93 64 118897 1059 46566042
Headache 133.49 9.93 697 118264 477655 46089446
Delirium 130.21 9.93 291 118670 36937 46530164
Miosis 129.83 9.93 119 118842 6538 46560563
Hypotension 126.68 9.93 1019 117942 231570 46335531
Somnolence 124.91 9.93 753 118208 155768 46411333
Malignant neoplasm progression 124.17 9.93 406 118555 64520 46502581
Procedural hypotension 121.58 9.93 60 118901 1142 46565959
Withdrawal syndrome 120.71 9.93 187 118774 17947 46549154
Sinusitis 118.67 9.93 94 118867 129674 46437427
Injection site pain 114.93 9.93 65 118896 107087 46460014
Depressed level of consciousness 112.03 9.93 320 118641 47249 46519852
Neuromuscular block prolonged 109.37 9.93 44 118917 502 46566599
Application site rash 106.88 9.93 72 118889 2510 46564591
Systemic lupus erythematosus 103.84 9.93 20 118941 65160 46501941
Sedation 103.51 9.93 199 118762 22711 46544390
Nasopharyngitis 103.31 9.93 145 118816 153853 46413248
Myoclonus 101.17 9.93 152 118809 14200 46552901
Pleural fibrosis 100.90 9.93 79 118882 3490 46563611
Respiratory rate decreased 99.27 9.93 74 118887 3036 46564065
Synovitis 98.88 9.93 18 118943 61057 46506044
Presbyacusis 96.51 9.93 70 118891 2752 46564349
Respiratory acidosis 91.92 9.93 95 118866 6053 46561048
Rash 88.12 9.93 540 118421 355972 46211129
Infusion related reaction 87.96 9.93 77 118884 101131 46465970
Hyperaesthesia 87.42 9.93 104 118857 7752 46559349
Bradypnoea 85.33 9.93 67 118894 2972 46564129
Deafness neurosensory 85.05 9.93 79 118882 4415 46562686
Pleural thickening 81.16 9.93 61 118900 2534 46564567
White blood cell count abnormal 79.81 9.93 81 118880 5051 46562050
Neoplasm progression 79.57 9.93 196 118765 26487 46540614
Arthralgia 78.22 9.93 576 118385 364027 46203074
Medication error 77.74 9.93 213 118748 30698 46536403
Blood magnesium increased 77.04 9.93 63 118898 2964 46564137
Injection site erythema 75.78 9.93 48 118913 74379 46492722
Abortion spontaneous 74.81 9.93 11 118950 43635 46523466
Hyperthermia malignant 74.60 9.93 37 118924 712 46566389
Fatigue 73.58 9.93 1101 117860 607596 45959505
Injection site reaction 73.48 9.93 16 118945 47833 46519268
Hypoventilation 73.47 9.93 70 118891 4040 46563061
Joint swelling 72.74 9.93 201 118760 165872 46401229
Asthma 72.14 9.93 76 118885 91466 46475635
Psoriasis 71.75 9.93 57 118904 78547 46488554
Oxygen saturation decreased 70.68 9.93 356 118605 68808 46498293
Application site erythema 70.13 9.93 74 118887 4830 46562271
Bronchospasm 69.20 9.93 135 118826 15572 46551529
Hand deformity 68.78 9.93 5 118956 34569 46532532
Application site vesicles 68.32 9.93 44 118917 1420 46565681
Glossodynia 67.81 9.93 15 118946 44358 46522743
Application site pruritus 67.31 9.93 66 118895 3947 46563154
Pulseless electrical activity 67.10 9.93 87 118874 7080 46560021
Breakthrough pain 64.82 9.93 39 118922 1113 46565988
Stress cardiomyopathy 64.46 9.93 89 118872 7695 46559406
Myalgia 64.13 9.93 136 118825 122952 46444149
Application site reaction 63.39 9.93 33 118928 706 46566395
Pulmonary oedema 63.15 9.93 278 118683 50827 46516274
Abdominal discomfort 62.50 9.93 188 118773 150977 46416124
Arthropathy 61.64 9.93 75 118886 84625 46482476
Poisoning 61.31 9.93 120 118841 13874 46553227
Intercepted product dispensing error 61.22 9.93 19 118942 92 46567009
Application site irritation 59.67 9.93 44 118917 1775 46565326
Epigastric discomfort 59.57 9.93 73 118888 5611 46561490
Confusional state 58.97 9.93 645 118316 159247 46407854
Circulatory collapse 58.40 9.93 153 118808 21471 46545630
Coma 57.97 9.93 298 118663 58051 46509050
Device expulsion 57.74 9.93 3 118958 27539 46539562
Labile blood pressure 57.68 9.93 42 118919 1661 46565440
Agitation 57.15 9.93 286 118675 55129 46511972
Infusion site coldness 57.00 9.93 21 118940 185 46566916
Drug diversion 55.96 9.93 32 118929 829 46566272
Therapeutic product effect incomplete 54.99 9.93 71 118890 78082 46489019
Hypermobility syndrome 54.49 9.93 29 118932 650 46566451
Toxic leukoencephalopathy 54.14 9.93 27 118934 526 46566575
Drug intolerance 53.79 9.93 193 118768 146856 46420245
Hypoxia 53.78 9.93 268 118693 51570 46515531
Therapeutic product effect increased 53.17 9.93 33 118928 997 46566104
Fear 51.65 9.93 122 118839 16050 46551051
Anaphylactic shock 51.27 9.93 140 118821 20134 46546967
Therapy naive 50.80 9.93 13 118948 25 46567076
Weight increased 50.64 9.93 231 118730 164242 46402859
Influenza 50.48 9.93 94 118867 89176 46477925
Treatment failure 50.04 9.93 101 118860 92986 46474115
Gamma-glutamyltransferase decreased 49.96 9.93 21 118940 270 46566831
Procedural complication 49.55 9.93 62 118899 4868 46562233
Blood pressure decreased 48.73 9.93 280 118681 56879 46510222
Peripheral swelling 48.67 9.93 222 118739 157849 46409252
Pain in extremity 48.31 9.93 424 118537 258256 46308845
Constipation 48.03 9.93 665 118296 173432 46393669
Faecaloma 47.53 9.93 77 118884 7675 46559426
Drug abuser 46.62 9.93 49 118912 3184 46563917
Urinary retention 46.27 9.93 159 118802 25902 46541199
Application site pain 45.99 9.93 54 118907 3969 46563132
Application site dermatitis 45.25 9.93 18 118943 199 46566902
Respiratory failure 44.39 9.93 402 118559 94414 46472687
Cancer pain 44.31 9.93 42 118919 2408 46564693
Therapeutic product effect prolonged 43.48 9.93 20 118941 323 46566778
Hepatic enzyme increased 42.89 9.93 90 118871 81697 46485404
Ventricular tachycardia 42.74 9.93 117 118844 16850 46550251
Post procedural complication 42.17 9.93 111 118850 15618 46551483
Muscle rigidity 41.93 9.93 84 118877 9877 46557224
Blood potassium increased 41.74 9.93 116 118845 16851 46550250
Drug tolerance 41.53 9.93 46 118915 3172 46563929
Condition aggravated 41.30 9.93 412 118549 244640 46322461
Bone cyst 40.65 9.93 37 118924 2014 46565087
General physical health deterioration 39.92 9.93 461 118500 115308 46451793
Lower respiratory tract infection 39.84 9.93 49 118912 55040 46512061
Osteopenia 39.81 9.93 114 118847 16847 46550254
Allodynia 39.80 9.93 22 118939 533 46566568
C-reactive protein abnormal 39.78 9.93 4 118957 21266 46545835
Chest discomfort 39.68 9.93 109 118852 90160 46476941
Product tampering 39.58 9.93 13 118948 78 46567023
Intentional self-injury 39.37 9.93 7 118954 24159 46542942
Kounis syndrome 39.26 9.93 29 118932 1173 46565928
Drug screen positive 39.21 9.93 49 118912 3842 46563259
Encephalopathy 38.70 9.93 179 118782 33410 46533691
Tachycardia 38.61 9.93 406 118555 99216 46467885
Pruritus 38.17 9.93 414 118547 241938 46325163
Diarrhoea 38.09 9.93 1111 117850 558491 46008610
Vasodilatation 37.74 9.93 38 118923 2347 46564754
Brain oedema 37.56 9.93 92 118869 12386 46554715
Bronchitis 37.49 9.93 141 118820 105838 46461263
Infusion site induration 37.17 9.93 24 118937 778 46566323
Injection site swelling 37.09 9.93 29 118932 40298 46526803
Laryngospasm 36.96 9.93 41 118920 2832 46564269
Multiple organ dysfunction syndrome 36.93 9.93 242 118719 51468 46515633
Mental status changes 36.77 9.93 193 118768 37895 46529206
Pericarditis 36.73 9.93 8 118953 23919 46543182
Unwanted awareness during anaesthesia 36.72 9.93 17 118944 279 46566822
Osteosclerosis 36.59 9.93 45 118916 3471 46563630
Contraindicated product administered 36.29 9.93 95 118866 79852 46487249
Hyperhidrosis 36.05 9.93 367 118594 88941 46478160
Injection site pruritus 36.03 9.93 29 118932 39714 46527387
Interstitial lung disease 35.93 9.93 51 118910 53898 46513203
Clonus 35.83 9.93 48 118913 4032 46563069
Bradycardia foetal 35.76 9.93 18 118943 358 46566743
Cerebrovascular accident 35.37 9.93 135 118826 100904 46466197
Neuromuscular blockade 35.25 9.93 17 118944 307 46566794
Hip arthroplasty 34.96 9.93 3 118958 18109 46548992
Renal injury 34.95 9.93 76 118885 9465 46557636
Product counterfeit 34.66 9.93 13 118948 121 46566980
Generalised tonic-clonic seizure 34.61 9.93 149 118812 26973 46540128
Completed suicide 34.58 9.93 543 118418 145377 46421724
Palpitations 34.17 9.93 126 118835 95133 46471968
Endotracheal intubation complication 33.44 9.93 18 118943 413 46566688
Horner's syndrome 33.14 9.93 9 118952 24 46567077
Swelling 33.10 9.93 184 118777 124327 46442774
Anhedonia 33.04 9.93 78 118883 10257 46556844
Carcinoid crisis 33.02 9.93 15 118946 235 46566866
Postoperative delirium 32.47 9.93 10 118951 47 46567054
Dizziness 32.43 9.93 642 118319 339772 46227329
Metastases to bone 32.23 9.93 108 118853 17368 46549733
Arthritis 32.04 9.93 96 118865 77220 46489881
Mental status changes postoperative 31.92 9.93 14 118947 201 46566900
Airway complication of anaesthesia 31.80 9.93 14 118947 203 46566898
Nasal congestion 31.53 9.93 46 118915 48067 46519034
Pulse absent 31.44 9.93 50 118911 4906 46562195
Oropharyngeal pain 30.80 9.93 92 118869 74076 46493025
Dystonia 30.75 9.93 80 118881 11177 46555924
Product administered at inappropriate site 30.65 9.93 34 118927 2349 46564752
Product dose omission issue 30.63 9.93 278 118683 168242 46398859
Knee arthroplasty 30.60 9.93 11 118950 23654 46543447
Herpes zoster 30.54 9.93 81 118880 67791 46499310
Application site perspiration 29.85 9.93 6 118955 0 46567101
Femoral hernia incarcerated 29.84 9.93 22 118939 887 46566214
Pregnancy 29.74 9.93 16 118945 27121 46539980
Dependence 29.16 9.93 30 118931 1901 46565200
Product administration error 28.97 9.93 113 118848 19568 46547533
Monoplegia 28.92 9.93 34 118927 2502 46564599
Gastrooesophageal reflux disease 28.91 9.93 95 118866 74249 46492852
Cauda equina syndrome 28.67 9.93 19 118942 644 46566457
Wound infection pseudomonas 28.35 9.93 26 118935 1429 46565672
Wound 27.97 9.93 41 118920 42761 46524340
Cyanosis 27.96 9.93 97 118864 15874 46551227
Pancreatic steatosis 27.88 9.93 22 118939 983 46566118
Lymphatic fistula 27.84 9.93 21 118940 877 46566224
Haemodynamic instability 27.69 9.93 61 118900 7664 46559437
Ocular hyperaemia 27.53 9.93 8 118953 19702 46547399
Anterior spinal artery syndrome 27.26 9.93 9 118952 55 46567046
Loss of consciousness 27.25 9.93 407 118554 107831 46459270
Restlessness 27.20 9.93 133 118828 25391 46541710
Seroma 26.99 9.93 30 118931 2077 46565024
Cardiac failure congestive 26.96 9.93 131 118830 91619 46475482
Wrong product administered 26.78 9.93 50 118911 5580 46561521
Application site burn 26.67 9.93 20 118941 828 46566273
Recurrence of neuromuscular blockade 26.67 9.93 10 118951 93 46567008
Head titubation 26.58 9.93 18 118943 633 46566468
Arterial haemorrhage 26.50 9.93 27 118934 1691 46565410
Neurotoxicity 26.39 9.93 86 118875 13631 46553470
Non-consummation 26.10 9.93 9 118952 64 46567037
Anorectal ulcer 26.10 9.93 9 118952 64 46567037
Procedural hypertension 26.10 9.93 14 118947 319 46566782
Dyspnoea 26.08 9.93 1062 117899 514486 46052615
Tumour pain 25.99 9.93 23 118938 1206 46565895
Pain 25.85 9.93 1473 117488 475475 46091626
Dyspnoea exertional 25.81 9.93 56 118905 50233 46516868
Spinal anaesthesia 25.73 9.93 8 118953 39 46567062
Hepatic ischaemia 25.59 9.93 16 118945 490 46566611
Uterine hypertonus 25.27 9.93 11 118950 155 46566946
Cyst 25.24 9.93 78 118883 12022 46555079
Vomiting 25.23 9.93 1402 117559 451392 46115709
Hypersensitivity 25.18 9.93 253 118708 150068 46417033
Upper respiratory tract infection 24.86 9.93 81 118880 63475 46503626
Confusion postoperative 24.77 9.93 12 118949 219 46566882
Airway peak pressure increased 24.77 9.93 13 118948 283 46566818
Diabetes mellitus 24.67 9.93 57 118904 50008 46517093
Upper airway obstruction 24.63 9.93 16 118945 524 46566577
Pseudopolyp 24.52 9.93 12 118949 224 46566877
Local anaesthetic systemic toxicity 24.44 9.93 14 118947 364 46566737
Transient ischaemic attack 24.24 9.93 32 118929 34871 46532230
Drug use disorder 23.75 9.93 32 118929 2703 46564398
Abdominal pain upper 23.74 9.93 246 118715 145059 46422042
Plasma cell myeloma 23.64 9.93 194 118767 44284 46522817
Spinal epidural haematoma 23.49 9.93 18 118943 770 46566331
Deformity 23.45 9.93 55 118906 7202 46559899
Visual impairment 23.40 9.93 89 118872 66600 46500501
Anaesthetic complication neurological 23.30 9.93 11 118950 189 46566912
Accidental death 23.29 9.93 26 118935 1809 46565292
Multiple sclerosis relapse 23.24 9.93 45 118916 42080 46525021
Red blood cell sedimentation rate increased 22.96 9.93 15 118946 22874 46544227
Type I hypersensitivity 22.78 9.93 29 118932 2317 46564784
Exposure during pregnancy 22.78 9.93 395 118566 107817 46459284
C-reactive protein increased 22.69 9.93 75 118886 58515 46508586
Tryptase increased 22.64 9.93 11 118950 202 46566899
Basal cell carcinoma 22.57 9.93 12 118949 20475 46546626
Myotonia 22.53 9.93 10 118951 148 46566953
Drug hypersensitivity 22.42 9.93 795 118166 243030 46324071
Sphincter of Oddi dysfunction 22.38 9.93 13 118948 347 46566754
Drug ineffective 22.30 9.93 1459 117502 676379 45890722
Gastrointestinal scarring 22.21 9.93 11 118950 211 46566890
Ventricular fibrillation 22.05 9.93 72 118889 11424 46555677
Tooth loss 22.03 9.93 51 118910 6622 46560479
Hypopnoea 21.99 9.93 29 118932 2399 46564702
Off label use 21.93 9.93 770 118191 379071 46188030
Post-traumatic neck syndrome 21.84 9.93 22 118939 1359 46565742
Product packaging issue 21.79 9.93 19 118942 977 46566124
Cardiogenic shock 21.67 9.93 91 118870 16293 46550808
Altered state of consciousness 21.64 9.93 117 118844 23231 46543870
Renal failure 21.57 9.93 408 118553 113186 46453915
Gouty tophus 21.49 9.93 10 118951 166 46566935
Pupil fixed 21.19 9.93 24 118937 1696 46565405
Cardiac output decreased 21.17 9.93 18 118943 894 46566207
Muscle relaxant therapy 21.12 9.93 9 118952 120 46566981
Cachexia 20.83 9.93 41 118920 4758 46562343
Psoriatic arthropathy 20.82 9.93 38 118923 36341 46530760
Coma scale abnormal 20.81 9.93 42 118919 4964 46562137
Acute postoperative sialadenitis 20.66 9.93 6 118955 22 46567079
Throat irritation 20.58 9.93 26 118935 28875 46538226
Pupils unequal 20.51 9.93 21 118940 1323 46565778
Hypoxic-ischaemic encephalopathy 20.42 9.93 37 118924 4036 46563065
Nephrolithiasis 20.31 9.93 33 118928 33018 46534083
Anticholinergic syndrome 20.24 9.93 24 118937 1782 46565319
Renal impairment 20.03 9.93 283 118678 74089 46493012
Hallucination 20.01 9.93 205 118756 49746 46517355
Poor quality product administered 19.98 9.93 31 118930 2978 46564123
Blood glucose increased 19.91 9.93 105 118856 71908 46495193
Exposure to extreme temperature 19.90 9.93 4 118957 0 46567101
Substance abuse 19.81 9.93 37 118924 4130 46562971
Retinopathy of prematurity 19.81 9.93 11 118950 269 46566832
Diabetic ketoacidosis 19.57 9.93 11 118950 18199 46548902
Ankylosing spondylitis 19.57 9.93 49 118912 6688 46560413
Anaesthetic complication pulmonary 19.48 9.93 7 118954 57 46567044
Eye irritation 19.40 9.93 9 118952 16605 46550496
Ear infection 19.39 9.93 18 118943 22995 46544106
Decerebrate posture 19.37 9.93 7 118954 58 46567043
Fluid retention 19.31 9.93 66 118895 50980 46516121
Apnoeic attack 19.30 9.93 11 118950 283 46566818
Mean arterial pressure decreased 19.26 9.93 9 118952 151 46566950
Rhinorrhoea 19.16 9.93 60 118901 47605 46519496
Emotional distress 19.13 9.93 139 118822 30568 46536533
Progressive multifocal leukoencephalopathy 19.12 9.93 3 118958 11343 46555758
Cataract 19.09 9.93 56 118905 45359 46521742
Vascular resistance systemic decreased 18.88 9.93 8 118953 105 46566996
Left ventricle outflow tract obstruction 18.87 9.93 10 118951 222 46566879
Potentiating drug interaction 18.86 9.93 35 118926 3888 46563213
Injection site bruising 18.86 9.93 39 118922 35597 46531504
Dermal absorption impaired 18.79 9.93 5 118956 12 46567089
Skin sensitisation 18.78 9.93 16 118945 797 46566304
Haemarthrosis 18.72 9.93 30 118931 2963 46564138
Liver disorder 18.68 9.93 42 118919 37204 46529897
Therapeutic response unexpected 18.56 9.93 84 118877 15532 46551569
Hypercreatininaemia 18.50 9.93 12 118949 392 46566709
Injection site warmth 18.50 9.93 6 118955 13766 46553335
Vasoconstriction 18.47 9.93 13 118948 487 46566614
Hyperreflexia 18.28 9.93 41 118920 5213 46561888
Brain injury 18.14 9.93 45 118916 6105 46560996
Exposure via ingestion 18.02 9.93 32 118929 3435 46563666
Generalised onset non-motor seizure 17.98 9.93 5 118956 15 46567086
Anaesthetic complication cardiac 17.74 9.93 5 118956 16 46567085
Product packaging quantity issue 17.69 9.93 18 118943 1126 46565975
Opiates positive 17.28 9.93 10 118951 265 46566836
Musculoskeletal disorder 17.28 9.93 9 118952 15536 46551565
Metastatic neoplasm 17.20 9.93 32 118929 3561 46563540
Atrioventricular block second degree 17.15 9.93 33 118928 3766 46563335
Manufacturing production issue 17.14 9.93 4 118957 4 46567097
Hypercapnia 17.11 9.93 37 118924 4589 46562512
Postpartum haemorrhage 17.11 9.93 22 118939 1775 46565326
Tachyarrhythmia 17.08 9.93 37 118924 4595 46562506
Facial nerve disorder 16.93 9.93 13 118948 558 46566543
Dyskinesia 16.93 9.93 129 118832 28796 46538305
Methaemoglobinaemia 16.83 9.93 24 118937 2138 46564963
Procedural nausea 16.67 9.93 14 118947 684 46566417
Oculogyric crisis 16.56 9.93 18 118943 1215 46565886
Disorientation 16.49 9.93 155 118806 36763 46530338
Paraplegia 16.37 9.93 25 118936 2369 46564732
Sneezing 16.34 9.93 6 118955 12735 46554366
Stridor 16.30 9.93 29 118932 3118 46563983
Lethargy 15.97 9.93 200 118761 50971 46516130
Helicobacter infection 15.96 9.93 5 118956 11731 46555370
Productive cough 15.72 9.93 71 118890 50644 46516457
Hypertonia 15.71 9.93 35 118926 4431 46562670
Post laminectomy syndrome 15.64 9.93 9 118952 236 46566865
Hyponatraemia 15.56 9.93 174 118787 101158 46465943
Tachyphylaxis 15.54 9.93 9 118952 239 46566862
Cancer fatigue 15.51 9.93 5 118956 28 46567073
Epistaxis 15.50 9.93 98 118863 64207 46502894
Loss of personal independence in daily activities 15.46 9.93 84 118877 57099 46510002
Opisthotonus 15.41 9.93 10 118951 327 46566774
Anaphylactoid reaction 15.37 9.93 30 118931 3461 46563640
Vein disorder 15.29 9.93 32 118929 3881 46563220
Pituitary apoplexy 15.28 9.93 7 118954 112 46566989
Oxygen saturation immeasurable 15.21 9.93 4 118957 9 46567092
Mean arterial pressure increased 15.21 9.93 4 118957 9 46567092
Intestinal pseudo-obstruction 15.15 9.93 13 118948 654 46566447
Fungal infection 15.04 9.93 33 118928 29487 46537614
Injection site rash 15.02 9.93 11 118950 15802 46551299
Tooth hypoplasia 14.95 9.93 6 118955 68 46567033
Central-alveolar hypoventilation 14.93 9.93 3 118958 0 46567101
Peroneal nerve palsy postoperative 14.93 9.93 3 118958 0 46567101
Blood pressure immeasurable 14.91 9.93 17 118944 1210 46565891
Pulmonary arterial hypertension 14.91 9.93 27 118934 25901 46541200
Rash pruritic 14.87 9.93 60 118901 44155 46522946
Pancreatic carcinoma metastatic 14.87 9.93 24 118937 2384 46564717
Decorticate posture 14.81 9.93 10 118951 350 46566751
Dental caries 14.79 9.93 59 118902 10320 46556781
Hypertension 14.77 9.93 384 118577 195972 46371129
Vitamin K deficiency 14.72 9.93 11 118950 453 46566648
Limb discomfort 14.70 9.93 22 118939 22754 46544347
Tuberculosis 14.65 9.93 4 118957 10261 46556840
Documented hypersensitivity to administered product 14.52 9.93 12 118949 573 46566528
Product storage error 14.38 9.93 6 118955 11786 46555315
Application site erosion 14.35 9.93 8 118953 197 46566904
Intervertebral disc compression 14.34 9.93 15 118946 969 46566132
Hepatic failure 14.28 9.93 139 118822 33277 46533824
Drug screen negative 14.25 9.93 10 118951 373 46566728
Chorea 14.21 9.93 16 118945 1124 46565977
Electrocardiogram ST segment elevation 14.18 9.93 30 118931 3665 46563436
Cardiac massage 14.15 9.93 4 118957 13 46567088
Gastroenteritis 14.13 9.93 25 118936 24194 46542907
Wheezing 14.11 9.93 79 118882 53307 46513794
Depressed mood 14.06 9.93 41 118920 33278 46533823
Nystagmus 14.05 9.93 39 118922 5660 46561441
Self-medication 14.05 9.93 22 118939 2130 46564971
Mean cell haemoglobin decreased 14.02 9.93 26 118935 2886 46564215
Infective pulmonary exacerbation of cystic fibrosis 14.01 9.93 5 118956 10802 46556299
Hepatorenal syndrome 13.97 9.93 20 118941 1788 46565313
Posturing 13.97 9.93 11 118950 490 46566611
Karnofsky scale worsened 13.92 9.93 4 118957 14 46567087
Infusion site haemorrhage 13.88 9.93 22 118939 2152 46564949
Oesophageal intramural haematoma 13.75 9.93 6 118955 85 46567016
Bezold-Jarisch reflex 13.71 9.93 4 118957 15 46567086
Breast cancer metastatic 13.67 9.93 70 118891 13608 46553493
Atrioventricular dissociation 13.66 9.93 8 118953 217 46566884
Inflammation 13.55 9.93 71 118890 48710 46518391
Pancreatic carcinoma 13.43 9.93 42 118919 6515 46560586
Eye swelling 13.39 9.93 19 118942 20084 46547017
Drug eruption 13.38 9.93 21 118940 21308 46545793
Erythema 13.36 9.93 270 118691 142550 46424551
Ventricular hypokinesia 13.28 9.93 31 118930 4047 46563054
Joint stiffness 13.24 9.93 31 118930 27077 46540024
Bulimia nervosa 13.15 9.93 11 118950 534 46566567
Malaise 13.14 9.93 700 118261 330532 46236569
Uterine atony 13.11 9.93 7 118954 158 46566943
Osteoporosis 13.10 9.93 56 118905 40552 46526549
Prescription drug used without a prescription 13.09 9.93 17 118944 1385 46565716
Blood cholesterol increased 13.02 9.93 55 118906 39958 46527143
Mastocytosis 13.00 9.93 10 118951 430 46566671
Vision blurred 12.98 9.93 135 118826 79573 46487528
Spinal cord injury 12.93 9.93 11 118950 547 46566554
Viral infection 12.91 9.93 37 118924 30198 46536903
Eczema 12.88 9.93 20 118941 20380 46546721
Nerve stimulation test abnormal 12.85 9.93 3 118958 3 46567098
Air embolism 12.85 9.93 8 118953 243 46566858
Laryngeal stenosis 12.81 9.93 12 118949 678 46566423
Gastrointestinal mucosa hyperaemia 12.80 9.93 7 118954 166 46566935
Systemic infection 12.79 9.93 12 118949 679 46566422
Resuscitation 12.76 9.93 15 118946 1104 46565997
Acute chest syndrome 12.72 9.93 11 118950 559 46566542
Foetal heart rate decreased 12.66 9.93 6 118955 104 46566997
Abscess neck 12.64 9.93 11 118950 564 46566537
Supraventricular tachycardia 12.64 9.93 67 118894 13203 46553898
Bronchiectasis 12.62 9.93 4 118957 9312 46557789
Sinus congestion 12.60 9.93 9 118952 13100 46554001
Product monitoring error 12.58 9.93 20 118941 1961 46565140
Gaze palsy 12.53 9.93 16 118945 1282 46565819
Product use issue 12.45 9.93 168 118793 94476 46472625
Therapeutic response decreased 12.44 9.93 62 118899 43083 46524018
Troponin increased 12.43 9.93 46 118915 7770 46559331
Procedural haemorrhage 12.37 9.93 22 118939 2364 46564737
Muscle spasms 12.35 9.93 230 118731 122883 46444218
Accidental exposure to product 12.32 9.93 94 118867 20987 46546114
Counterfeit product administered 12.18 9.93 4 118957 24 46567077
Pneumonia 12.14 9.93 811 118150 375509 46191592
Spontaneous haemorrhage 12.12 9.93 7 118954 185 46566916
Type 2 diabetes mellitus 12.07 9.93 20 118941 19855 46547246
Somatosensory evoked potentials abnormal 12.00 9.93 3 118958 5 46567096
Joint injury 11.97 9.93 19 118942 19190 46547911
Complex regional pain syndrome 11.96 9.93 20 118941 2046 46565055
Inappropriate antidiuretic hormone secretion 11.92 9.93 11 118950 14091 46553010
Haematemesis 11.91 9.93 119 118842 28687 46538414
Respiratory distress 11.85 9.93 129 118832 31787 46535314
No adverse event 11.80 9.93 46 118915 34185 46532916
Dehydration 11.77 9.93 508 118453 159032 46408069
Swelling face 11.72 9.93 83 118878 52976 46514125
Euthyroid sick syndrome 11.71 9.93 5 118956 67 46567034
Retinal detachment 11.70 9.93 34 118927 5066 46562035
Quadriplegia 11.68 9.93 18 118943 1719 46565382
Lagophthalmos 11.67 9.93 8 118953 287 46566814
Gastrointestinal vascular malformation 11.65 9.93 4 118957 28 46567073
Spinal cord infarction 11.65 9.93 8 118953 288 46566813
Narcotic bowel syndrome 11.63 9.93 6 118955 126 46566975
Carpal tunnel syndrome 11.57 9.93 14 118947 15845 46551256
Visceral congestion 11.57 9.93 8 118953 291 46566810
Implant site extravasation 11.54 9.93 10 118951 510 46566591
Chest expansion decreased 11.53 9.93 4 118957 29 46567072
Balance disorder 11.46 9.93 107 118854 64414 46502687
Dysaesthesia pharynx 11.46 9.93 6 118955 130 46566971
Vasoplegia syndrome 11.40 9.93 14 118947 1078 46566023
Pneumothorax 11.39 9.93 70 118891 14559 46552542
Eye pain 11.35 9.93 35 118926 27905 46539196
Application site laceration 11.33 9.93 3 118958 7 46567094
Toxic skin eruption 11.27 9.93 9 118952 12378 46554723
Hemianopia homonymous 11.24 9.93 11 118950 656 46566445
Acne 11.23 9.93 21 118940 19898 46547203
Peritonitis bacterial 11.22 9.93 4 118957 8649 46558452
Arteriospasm coronary 11.22 9.93 27 118934 3594 46563507
Infection parasitic 11.20 9.93 8 118953 307 46566794
Wound dehiscence 11.07 9.93 31 118930 4523 46562578
Drug resistance 10.99 9.93 17 118944 17351 46549750
Sensitivity to weather change 10.99 9.93 35 118926 5481 46561620
Normal newborn 10.99 9.93 37 118924 5964 46561137
Cholelithiasis 10.91 9.93 56 118905 38625 46528476
Conjunctivitis 10.85 9.93 14 118947 15410 46551691
Coagulation time prolonged 10.84 9.93 15 118946 1299 46565802
Non-cardiogenic pulmonary oedema 10.84 9.93 10 118951 554 46566547
Hypobarism 10.79 9.93 3 118958 9 46567092
Systolic anterior motion of mitral valve 10.79 9.93 3 118958 9 46567092
Excessive dynamic airway collapse 10.79 9.93 3 118958 9 46567092
Obstetric procedure complication 10.79 9.93 3 118958 9 46567092
Lumbosacral plexopathy 10.79 9.93 3 118958 9 46567092
Femur fracture 10.76 9.93 53 118908 36944 46530157
Sputum discoloured 10.76 9.93 10 118951 12768 46554333
Nightmare 10.74 9.93 16 118945 16582 46550519
Multiple lentigines syndrome 10.70 9.93 7 118954 232 46566869
Harlequin syndrome 10.69 9.93 4 118957 37 46567064
Dry skin 10.68 9.93 61 118900 40955 46526146
Memory impairment 10.64 9.93 136 118825 77201 46489900
Dysphonia 10.62 9.93 56 118905 38358 46528743
Ill-defined disorder 10.62 9.93 34 118927 26793 46540308
Tenosynovitis 10.59 9.93 3 118958 7512 46559589
Atrioventricular block complete 10.59 9.93 43 118918 7584 46559517
Throat tightness 10.57 9.93 23 118938 20616 46546485
Respiratory paralysis 10.55 9.93 3 118958 10 46567091
Device issue 10.46 9.93 22 118939 19958 46547143
Aortic valve stenosis 10.45 9.93 24 118937 3100 46564001
Blood creatinine decreased 10.45 9.93 31 118930 4673 46562428
Urticaria 10.40 9.93 225 118736 117667 46449434
Uterine hypotonus 10.38 9.93 5 118956 90 46567011
Premature separation of placenta 10.37 9.93 17 118944 1711 46565390
Gastric cancer 10.35 9.93 23 118938 2906 46564195
Postoperative wound infection 10.34 9.93 47 118914 8706 46558395
Cytomegalovirus infection 10.34 9.93 19 118942 18125 46548976
Substance use disorder 10.32 9.93 4 118957 41 46567060
Intensive care unit delirium 10.32 9.93 4 118957 41 46567060
Rhythm idioventricular 10.30 9.93 6 118955 161 46566940
Localised infection 10.26 9.93 29 118932 23772 46543329
Caesarean section 10.25 9.93 75 118886 16528 46550573
Platelet disorder 10.23 9.93 16 118945 1547 46565554
Erythema multiforme 10.23 9.93 6 118955 9698 46557403
Incontinence 10.23 9.93 51 118910 9811 46557290
Stomatitis 10.19 9.93 118 118843 68179 46498922
Hypovolaemia 10.16 9.93 51 118910 9837 46557264
Juvenile myoclonic epilepsy 10.13 9.93 3 118958 12 46567089
Prinzmetal angina 10.10 9.93 11 118950 744 46566357
Eosinophil cationic protein increased 10.07 9.93 4 118957 44 46567057
Central nervous system lesion 10.06 9.93 6 118955 9609 46557492
Transplant rejection 10.02 9.93 6 118955 9590 46557511
Infusion site mass 9.96 9.93 12 118949 906 46566195
Product outer packaging issue 9.94 9.93 3 118958 13 46567088
Gingival cancer 9.94 9.93 3 118958 13 46567088

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 4474.12 10.59 2902 89279 79170 29781127
Toxicity to various agents 1728.27 10.59 2405 89776 174778 29685519
Accidental overdose 645.40 10.59 498 91683 17777 29842520
Incorrect route of product administration 549.32 10.59 374 91807 10941 29849356
Serotonin syndrome 524.10 10.59 437 91744 17454 29842843
Respiratory arrest 498.79 10.59 529 91652 28729 29831568
Overdose 451.20 10.59 876 91305 83461 29776836
Cardio-respiratory arrest 437.30 10.59 696 91485 56610 29803687
Product adhesion issue 408.58 10.59 158 92023 1307 29858990
Cardiac arrest 382.89 10.59 867 91314 91983 29768314
Respiratory depression 374.75 10.59 299 91882 11204 29849093
Intentional product misuse 309.36 10.59 453 91728 34214 29826083
Hyperthermia malignant 258.67 10.59 122 92059 1712 29858585
Miosis 240.27 10.59 196 91985 7580 29852717
Drug withdrawal syndrome 237.73 10.59 299 91882 19510 29840787
Drug dependence 231.39 10.59 306 91875 20989 29839308
Depressed level of consciousness 213.80 10.59 405 91776 37817 29822480
Unresponsive to stimuli 194.58 10.59 316 91865 26103 29834194
Inadequate analgesia 192.60 10.59 114 92067 2594 29857703
Accidental exposure to product by child 181.40 10.59 91 92090 1472 29858825
Anaphylactic reaction 168.35 10.59 306 91875 27676 29832621
Hyperaesthesia 152.07 10.59 109 92072 3464 29856833
Death 150.32 10.59 1718 90463 355565 29504732
Product quality issue 147.06 10.59 231 91950 18543 29841754
Pain 142.63 10.59 964 91217 171677 29688620
Somnolence 140.46 10.59 630 91551 96133 29764164
Product prescribing error 138.22 10.59 211 91970 16522 29843775
Delirium 137.63 10.59 352 91829 40279 29820018
Malignant neoplasm progression 136.86 10.59 511 91670 71776 29788521
Pulmonary oedema 136.75 10.59 369 91812 43606 29816691
Neoplasm progression 134.62 10.59 217 91964 17806 29842491
Anaesthetic complication 129.26 10.59 64 92117 1005 29859292
Delayed recovery from anaesthesia 124.54 10.59 55 92126 656 29859641
Wrong technique in product usage process 113.99 10.59 278 91903 30877 29829420
Headache 105.49 10.59 255 91926 182051 29678246
Apnoea 99.24 10.59 109 92072 6149 29854148
Product complaint 97.09 10.59 104 92077 5702 29854595
Withdrawal syndrome 90.28 10.59 140 92041 11110 29849187
Fear 88.68 10.59 136 92045 10689 29849608
Injury 86.06 10.59 200 91981 21531 29838766
Amnestic disorder 79.24 10.59 27 92154 148 29860149
Counterfeit product administered 78.06 10.59 27 92154 156 29860141
Drug abuser 70.38 10.59 77 92104 4324 29855973
Myalgia 69.55 10.59 80 92101 76587 29783710
Neuromuscular block prolonged 69.36 10.59 30 92151 339 29859958
Arthralgia 68.58 10.59 203 91978 135588 29724709
Pruritus 68.55 10.59 165 92016 118039 29742258
Cardiac failure congestive 68.35 10.59 96 92085 84311 29775986
Diarrhoea 67.71 10.59 680 91501 333423 29526874
Rash 67.71 10.59 332 91849 191557 29668740
Post procedural complication 67.67 10.59 126 92055 11600 29848697
Bradypnoea 66.99 10.59 52 92129 1869 29858428
Sedation complication 66.98 10.59 38 92143 796 29859501
Anaphylactic shock 65.82 10.59 138 92043 13855 29846442
Brain oedema 65.13 10.59 128 92053 12270 29848027
Drug use disorder 64.84 10.59 64 92117 3184 29857113
Myocardial infarction 64.74 10.59 186 91995 125439 29734858
Coronary artery disease 63.55 10.59 37 92144 49675 29810622
Propofol infusion syndrome 63.01 10.59 37 92144 829 29859468
Anhedonia 62.80 10.59 101 92080 8268 29852029
Renal injury 62.71 10.59 122 92059 11607 29848690
Cough 61.17 10.59 191 91990 125451 29734846
Narcotic bowel syndrome 60.90 10.59 21 92160 120 29860177
Respiratory rate decreased 60.84 10.59 48 92133 1767 29858530
Intensive care unit acquired weakness 60.16 10.59 36 92145 836 29859461
Muscle rigidity 58.89 10.59 110 92071 10151 29850146
Oxygen saturation decreased 56.42 10.59 274 91907 43166 29817131
Brain injury 56.07 10.59 77 92104 5471 29854826
Emotional distress 55.87 10.59 139 92042 15626 29844671
Product counterfeit 55.67 10.59 21 92160 161 29860136
Procedural hypotension 54.81 10.59 36 92145 989 29859308
Respiratory acidosis 54.52 10.59 66 92115 4136 29856161
Rheumatoid arthritis 53.60 10.59 30 92151 41167 29819130
Drug diversion 53.48 10.59 34 92147 882 29859415
Coma 52.43 10.59 255 91926 40194 29820103
Psoriasis 52.42 10.59 33 92148 42473 29817824
Hypercapnia 51.15 10.59 61 92120 3763 29856534
Treatment failure 50.02 10.59 22 92159 34657 29825640
Pulseless electrical activity 49.65 10.59 77 92104 6110 29854187
Procedural complication 49.40 10.59 65 92116 4432 29855865
Asthma 49.03 10.59 25 92156 36149 29824148
Compartment syndrome 48.98 10.59 49 92132 2478 29857819
Syncope 48.81 10.59 119 92062 84784 29775513
Cyanosis 48.52 10.59 111 92070 11824 29848473
Nasopharyngitis 47.56 10.59 67 92114 58782 29801515
Hypoxia 47.27 10.59 280 91901 47574 29812723
Drug interaction 46.77 10.59 868 91313 198700 29661597
Hypotension 45.51 10.59 868 91313 199697 29660600
Myoclonus 44.69 10.59 115 92066 13197 29847100
Fatigue 44.52 10.59 707 91474 319966 29540331
Blood glucose increased 44.05 10.59 76 92105 61454 29798843
Prescription drug used without a prescription 43.65 10.59 34 92147 1228 29859069
Accidental death 41.56 10.59 41 92140 2038 29858259
Peripheral swelling 41.42 10.59 78 92103 60996 29799301
Sedation 40.82 10.59 127 92054 16246 29844051
Application site reaction 40.50 10.59 22 92159 422 29859875
Laryngospasm 39.69 10.59 33 92148 1310 29858987
Arthritis 39.32 10.59 13 92168 24388 29835909
Weight increased 39.23 10.59 110 92071 74803 29785494
Airway complication of anaesthesia 39.11 10.59 15 92166 121 29860176
Bradycardia 38.84 10.59 339 91842 65187 29795110
Cerebrovascular accident 38.44 10.59 130 92051 83347 29776950
Negative pressure pulmonary oedema 38.33 10.59 17 92164 205 29860092
Hypoglycaemia 38.32 10.59 61 92120 50920 29809377
Agitation 38.12 10.59 291 91890 53782 29806515
Tryptase increased 38.03 10.59 17 92164 209 29860088
Blood cholesterol increased 37.96 10.59 4 92177 16966 29843331
Malaise 37.89 10.59 330 91851 166632 29693665
Dyspnoea exertional 37.84 10.59 32 92149 35398 29824899
Anaesthetic complication neurological 37.40 10.59 19 92162 316 29859981
Hypoxic-ischaemic encephalopathy 37.14 10.59 58 92123 4629 29855668
Blood pressure measurement 36.92 10.59 15 92166 143 29860154
Tachyphylaxis 35.97 10.59 13 92168 87 29860210
Febrile neutropenia 35.62 10.59 188 91993 106505 29753792
Brain death 35.22 10.59 41 92140 2465 29857832
Coma blister 34.89 10.59 12 92169 68 29860229
Drug tolerance 34.87 10.59 38 92143 2124 29858173
Unevaluable event 34.67 10.59 191 91990 31594 29828703
Constipation 34.48 10.59 513 91668 112393 29747904
Cardiac failure 34.40 10.59 136 92045 83282 29777015
Coma scale abnormal 34.34 10.59 47 92134 3329 29856968
Haemodynamic instability 34.20 10.59 76 92105 7939 29852358
Poisoning 33.84 10.59 94 92087 11288 29849009
Hypoventilation 33.68 10.59 44 92137 2979 29857318
Trigemino-cardiac reflex 33.66 10.59 13 92168 107 29860190
Dyspnoea 33.57 10.59 776 91405 332519 29527778
Respiratory failure 33.40 10.59 464 91717 100178 29760119
Dizziness 33.27 10.59 412 91769 194497 29665800
Tachycardia 33.15 10.59 360 91821 73379 29786918
Medication error 32.98 10.59 140 92041 20832 29839465
Blood pressure decreased 32.43 10.59 252 91929 46823 29813474
Application site rash 32.35 10.59 24 92157 805 29859492
Sinusitis 32.21 10.59 33 92148 33312 29826985
Product dose omission issue 31.98 10.59 159 92022 91472 29768825
Infusion related reaction 31.96 10.59 47 92134 40517 29819780
Therapeutic product effect increased 31.79 10.59 22 92159 660 29859637
Confusional state 31.72 10.59 587 91594 134247 29726050
Toxic leukoencephalopathy 31.64 10.59 15 92166 213 29860084
Ventricular fibrillation 31.11 10.59 110 92071 15028 29845269
Product administered at inappropriate site 30.40 10.59 31 92150 1604 29858693
Upper airway obstruction 30.37 10.59 20 92161 552 29859745
Intentional product use issue 30.25 10.59 204 91977 36236 29824061
Angina pectoris 29.91 10.59 28 92153 29490 29830807
Cytomegalovirus infection 29.71 10.59 18 92163 23656 29836641
Diabetes mellitus 29.69 10.59 52 92129 41813 29818484
Postoperative ileus 29.33 10.59 21 92160 666 29859631
Tachypnoea 29.33 10.59 107 92074 14845 29845452
Epistaxis 29.08 10.59 76 92105 52905 29807392
Anterograde amnesia 29 10.59 13 92168 161 29860136
Cancer pain 28.78 10.59 37 92144 2465 29857832
Sinus tachycardia 28.78 10.59 109 92072 15395 29844902
Myocardial stunning 28.68 10.59 7 92174 7 29860290
Drug resistance 28.67 10.59 13 92168 20120 29840177
Anion gap 28.16 10.59 20 92161 626 29859671
Gastrointestinal haemorrhage 27.86 10.59 147 92034 83299 29776998
Gait disturbance 27.69 10.59 127 92054 74650 29785647
Eosinophilia 27.60 10.59 17 92164 22143 29838154
Bronchospasm 27.46 10.59 82 92099 10256 29850041
Disorientation 27.35 10.59 178 92003 31240 29829057
Therapy naive 27.33 10.59 7 92174 10 29860287
Conversion disorder 27.22 10.59 16 92165 359 29859938
Oxygen saturation immeasurable 27.09 10.59 9 92172 45 29860252
International normalised ratio increased 26.57 10.59 68 92113 47671 29812626
Self-medication 26.51 10.59 34 92147 2260 29858037
Recurrence of neuromuscular blockade 26.27 10.59 11 92170 114 29860183
Bone marrow failure 26.01 10.59 32 92149 29753 29830544
Hyperhidrosis 25.88 10.59 318 91863 66772 29793525
Influenza 25.58 10.59 60 92121 43338 29816959
Pyrexia 25.47 10.59 701 91480 293788 29566509
Fall 25.47 10.59 400 91781 181472 29678825
Application site pruritus 25.31 10.59 26 92155 1357 29858940
Abdominal discomfort 25.27 10.59 72 92109 48719 29811578
Breakthrough pain 25.03 10.59 18 92163 575 29859722
Injection site pain 24.99 10.59 34 92147 30276 29830021
Diabetic ketoacidosis 24.92 10.59 9 92172 15977 29844320
Oculocardiac reflex 24.68 10.59 9 92172 62 29860235
Tooth loss 24.61 10.59 44 92137 3925 29856372
Stress cardiomyopathy 24.59 10.59 27 92154 1522 29858775
Clonus 24.42 10.59 34 92147 2447 29857850
Pancreatitis acute 24.17 10.59 26 92155 25669 29834628
Metastases to bone 24.15 10.59 75 92106 9583 29850714
Multiple organ dysfunction syndrome 24.09 10.59 300 91881 63187 29797110
Seizure like phenomena 23.91 10.59 17 92164 533 29859764
Haemoglobin decreased 23.91 10.59 230 91951 113868 29746429
Suicide attempt 23.89 10.59 48 92133 36649 29823648
Joint swelling 23.79 10.59 70 92111 46876 29813421
Off label use 23.77 10.59 585 91596 248705 29611592
Autonomic nervous system imbalance 23.56 10.59 33 92148 2388 29857909
Pain in extremity 23.17 10.59 222 91959 109999 29750298
Accidental poisoning 22.89 10.59 16 92165 488 29859809
Bladder dilatation 22.82 10.59 24 92157 1288 29859009
Drug detoxification 22.48 10.59 12 92169 222 29860075
Anaemia 22.37 10.59 479 91702 207513 29652784
Oedema peripheral 22.31 10.59 213 91968 105619 29754678
Acidosis 22.16 10.59 76 92105 10225 29850072
Transient ischaemic attack 22.08 10.59 27 92154 25173 29835124
Acute myocardial infarction 22.01 10.59 86 92095 52853 29807444
Eastern Cooperative Oncology Group performance status worsened 22.00 10.59 15 92166 439 29859858
Neuropathy peripheral 21.96 10.59 127 92054 70348 29789949
Thermophobia 21.95 10.59 9 92172 88 29860209
Influenza like illness 21.84 10.59 28 92153 25577 29834720
Atrial fibrillation 21.79 10.59 220 91961 107904 29752393
Rectal haemorrhage 21.65 10.59 47 92134 34892 29825405
Spinal muscular atrophy 21.65 10.59 11 92170 183 29860114
Visual acuity reduced 21.39 10.59 11 92170 15835 29844462
Drug screen positive 21.35 10.59 44 92137 4363 29855934
Poor quality product administered 21.30 10.59 26 92155 1643 29858654
Chest discomfort 20.80 10.59 71 92110 45409 29814888
Pelvic pain 20.69 10.59 29 92152 2100 29858197
Fluid retention 20.65 10.59 28 92153 24970 29835327
Leukoencephalopathy 20.63 10.59 41 92140 3961 29856336
Drug-induced liver injury 20.60 10.59 21 92160 21253 29839044
Basal cell carcinoma 20.47 10.59 12 92169 16056 29844241
Anaesthetic complication pulmonary 20.46 10.59 6 92175 18 29860279
Prostate cancer metastatic 20.45 10.59 47 92134 5020 29855277
Pneumonitis chemical 20.43 10.59 10 92171 153 29860144
Increased bronchial secretion 20.39 10.59 23 92158 1336 29858961
Application site dermatitis 20.30 10.59 7 92174 40 29860257
Nephrolithiasis 20.28 10.59 28 92153 24782 29835515
Inappropriate schedule of product administration 20.23 10.59 199 91982 39529 29820768
Hypotonic-hyporesponsive episode 19.98 10.59 6 92175 20 29860277
Electrocardiogram ST segment elevation 19.95 10.59 43 92138 4399 29855898
Sinus arrest 19.93 10.59 24 92157 1496 29858801
Hyperlipidaemia 19.77 10.59 9 92172 13898 29846399
Herpes zoster 19.63 10.59 39 92142 29904 29830393
Intercepted product dispensing error 19.63 10.59 8 92173 77 29860220
Glycosylated haemoglobin increased 19.39 10.59 3 92178 9488 29850809
Application site hypersensitivity 19.35 10.59 9 92172 122 29860175
Palpitations 19.32 10.59 47 92134 33526 29826771
Product contamination 19.29 10.59 16 92165 633 29859664
Urinary tract infection 19.26 10.59 140 92041 73519 29786778
Arteriospasm coronary 18.83 10.59 31 92150 2587 29857710
Dependence 18.82 10.59 21 92160 1205 29859092
Acute lung injury 18.81 10.59 20 92161 1087 29859210
Metabolic acidosis 18.76 10.59 187 91994 37274 29823023
Mental status changes 18.53 10.59 185 91996 36894 29823403
Peritonitis bacterial 18.44 10.59 6 92175 11372 29848925
Electrocardiogram ST segment depression 18.40 10.59 29 92152 2333 29857964
Melaena 18.20 10.59 46 92135 32391 29827906
Blood pressure increased 18.19 10.59 138 92043 71790 29788507
Application site irritation 17.91 10.59 16 92165 701 29859596
Pancreatic carcinoma 17.90 10.59 59 92122 7778 29852519
Stress 17.83 10.59 115 92066 20120 29840177
Hypopnoea 17.78 10.59 20 92161 1158 29859139
Agranulocytosis 17.70 10.59 25 92156 21917 29838380
Hyperventilation 17.62 10.59 29 92152 2420 29857877
Device failure 17.61 10.59 27 92154 2121 29858176
Type 2 diabetes mellitus 17.60 10.59 10 92171 13612 29846685
Ventricular arrhythmia 17.56 10.59 40 92141 4248 29856049
Haematuria 17.28 10.59 75 92106 44759 29815538
Pulse absent 17.06 10.59 46 92135 5427 29854870
Pulmonary congestion 17.03 10.59 79 92102 12208 29848089
Vomiting 16.98 10.59 833 91348 218985 29641312
Local anaesthetic systemic toxicity 16.98 10.59 9 92172 164 29860133
Acute respiratory distress syndrome 16.91 10.59 127 92054 23345 29836952
Intentional overdose 16.85 10.59 68 92113 41413 29818884
Blood catecholamines increased 16.81 10.59 5 92176 16 29860281
Sweat gland disorder 16.79 10.59 8 92173 115 29860182
Platelet count decreased 16.72 10.59 228 91953 105901 29754396
Sciatic nerve neuropathy 16.68 10.59 7 92174 73 29860224
Haematochezia 16.64 10.59 52 92129 34170 29826127
Systolic anterior motion of mitral valve 16.62 10.59 6 92175 40 29860257
Anal stenosis 16.54 10.59 8 92173 119 29860178
Oedema 16.52 10.59 72 92109 42921 29817376
Non-cardiogenic pulmonary oedema 16.47 10.59 15 92166 674 29859623
Drug reaction with eosinophilia and systemic symptoms 16.30 10.59 40 92141 28448 29831849
Product tampering 16.25 10.59 6 92175 43 29860254
Bronchitis 15.98 10.59 64 92117 39061 29821236
Therapeutic product effect decreased 15.97 10.59 148 92033 28928 29831369
Angina unstable 15.95 10.59 9 92172 12301 29847996
Photosensitivity reaction 15.91 10.59 5 92176 9689 29850608
Paraplegia 15.86 10.59 29 92152 2632 29857665
Endotracheal intubation complication 15.84 10.59 11 92170 332 29859965
Methaemoglobinaemia 15.79 10.59 28 92153 2482 29857815
White blood cell count decreased 15.62 10.59 174 92007 83773 29776524
Myelodysplastic syndrome 15.54 10.59 21 92160 18757 29841540
Tuberculosis 15.52 10.59 3 92178 8074 29852223
Areflexia 15.41 10.59 29 92152 2690 29857607
Resuscitation 15.41 10.59 19 92162 1213 29859084
Injection site erythema 15.38 10.59 12 92169 13822 29846475
Posthaemorrhagic hydrocephalus 15.31 10.59 7 92174 91 29860206
Hepatic cirrhosis 15.26 10.59 16 92165 15983 29844314
Erectile dysfunction 15.23 10.59 20 92161 18082 29842215
Pancytopenia 15.15 10.59 178 92003 84874 29775423
Meningococcal bacteraemia 15.12 10.59 4 92177 7 29860290
Postoperative respiratory distress 15.12 10.59 4 92177 7 29860290
Abdominal compartment syndrome 15.12 10.59 16 92165 865 29859432
Vasoplegia syndrome 14.94 10.59 19 92162 1252 29859045
Vision blurred 14.90 10.59 72 92109 41744 29818553
Application site erythema 14.88 10.59 26 92155 2277 29858020
Spinal cord compression 14.79 10.59 34 92147 3632 29856665
Acute kidney injury 14.70 10.59 691 91490 273151 29587146
Cataract 14.70 10.59 28 92153 21807 29838490
Upper respiratory tract infection 14.63 10.59 40 92141 27436 29832861
Skin exfoliation 14.50 10.59 31 92150 23141 29837156
Anaesthetic complication cardiac 14.44 10.59 5 92176 29 29860268
Product use in unapproved indication 14.41 10.59 151 92030 73542 29786755
Hypercapnic coma 14.39 10.59 8 92173 161 29860136
Trismus 14.38 10.59 26 92155 2339 29857958
Eczema 14.36 10.59 12 92169 13357 29846940
Preternatural anus 14.36 10.59 7 92174 106 29860191
Vagus nerve paralysis 14.36 10.59 3 92178 0 29860297
Hippocampal atrophy 14.36 10.59 3 92178 0 29860297
Substance abuse 14.33 10.59 51 92130 6989 29853308
Presyncope 14.28 10.59 17 92164 16039 29844258
Diabetes mellitus inadequate control 14.28 10.59 11 92170 12751 29847546
Neuroendocrine tumour of the lung metastatic 14.25 10.59 7 92174 108 29860189
Lethargy 14.24 10.59 185 91996 39334 29820963
Pulmonary haemorrhage 14.23 10.59 62 92119 9330 29850967
Spinal column injury 14.20 10.59 11 92170 394 29859903
Progressive multifocal leukoencephalopathy 14.17 10.59 5 92176 9008 29851289
Loss of personal independence in daily activities 14.16 10.59 28 92153 21507 29838790
Lower respiratory tract infection 14.14 10.59 39 92142 26675 29833622
Performance status decreased 14.13 10.59 35 92146 3922 29856375
Chest pain 14.08 10.59 266 91915 117361 29742936
Acute myeloid leukaemia 14.04 10.59 21 92160 17985 29842312
Chronic obstructive pulmonary disease 13.90 10.59 84 92097 46042 29814255
Mechanical ventilation complication 13.89 10.59 4 92177 11 29860286
Paraesthesia 13.84 10.59 104 92077 54223 29806074
Capillary nail refill test abnormal 13.77 10.59 5 92176 34 29860263
Application site pain 13.77 10.59 21 92160 1642 29858655
PCO2 increased 13.68 10.59 13 92168 617 29859680
Kounis syndrome 13.67 10.59 21 92160 1652 29858645
Viral infection 13.59 10.59 16 92165 15169 29845128
Injection site swelling 13.59 10.59 5 92176 8775 29851522
Dental caries 13.57 10.59 37 92144 4394 29855903
Injection site bruising 13.53 10.59 3 92178 7335 29852962
Tendonitis 13.45 10.59 4 92177 8032 29852265
Air embolism 13.43 10.59 7 92174 123 29860174
Lactic acidosis 13.42 10.59 50 92131 31163 29829134
Eye pain 13.40 10.59 10 92171 11779 29848518
Locked-in syndrome 13.33 10.59 9 92172 259 29860038
Bronchopulmonary aspergillosis 13.23 10.59 11 92170 12273 29848024
Nasal congestion 13.22 10.59 23 92158 18543 29841754
Laryngeal cancer metastatic 13.20 10.59 6 92175 77 29860220
Exposure during pregnancy 13.16 10.59 6 92175 9255 29851042
Social anxiety disorder 13.12 10.59 9 92172 266 29860031
Gastrooesophageal reflux disease 13.02 10.59 53 92128 32202 29828095
Injection site haemorrhage 12.98 10.59 4 92177 7851 29852446
Anion gap abnormal 12.85 10.59 7 92174 135 29860162
Hepatitis C 12.83 10.59 13 92168 13192 29847105
Pulmonary alveolar haemorrhage 12.82 10.59 47 92134 6534 29853763
Therapeutic product effect prolonged 12.80 10.59 9 92172 277 29860020
Swollen tongue 12.80 10.59 13 92168 13179 29847118
Hypophonesis 12.76 10.59 4 92177 16 29860281
Colorectal cancer 12.71 10.59 21 92160 1758 29858539
Psoriatic arthropathy 12.67 10.59 18 92163 15743 29844554
Unwanted awareness during anaesthesia 12.66 10.59 5 92176 44 29860253
Lymphadenopathy 12.60 10.59 36 92145 24340 29835957
Mucous stools 12.48 10.59 15 92166 933 29859364
Application site vesicles 12.43 10.59 12 92169 581 29859716
Erythema 12.33 10.59 166 92015 77285 29783012
Tumour necrosis 12.32 10.59 16 92165 1077 29859220
Mitochondrial encephalomyopathy 12.29 10.59 3 92178 3 29860294
Glossopharyngeal nerve paralysis 12.29 10.59 3 92178 3 29860294
Pupil fixed 12.25 10.59 21 92160 1811 29858486
Product administration error 12.23 10.59 81 92100 14296 29846001
Pathological fracture 12.19 10.59 34 92147 4092 29856205
Paralysis recurrent laryngeal nerve 12.19 10.59 5 92176 49 29860248
Clinical trial participant 12.13 10.59 6 92175 94 29860203
Mean arterial pressure decreased 12.11 10.59 7 92174 152 29860145
Product communication issue 12.10 10.59 5 92176 50 29860247
Toxicologic test abnormal 12.09 10.59 12 92169 601 29859696
Diaphragmatic rupture 12.04 10.59 4 92177 20 29860277
Rash pruritic 11.91 10.59 33 92148 22539 29837758
Ventricular tachycardia 11.89 10.59 119 92062 23743 29836554
Atrial septal defect 11.84 10.59 3 92178 6698 29853599
Substance dependence 11.84 10.59 10 92171 406 29859891
Weight bearing difficulty 11.77 10.59 14 92167 861 29859436
Pain in jaw 11.77 10.59 12 92169 12144 29848153
Airway peak pressure increased 11.73 10.59 4 92177 22 29860275
Contusion 11.65 10.59 53 92128 31227 29829070
Secondary adrenocortical insufficiency 11.64 10.59 15 92166 1002 29859295
Claustrophobia 11.53 10.59 8 92173 241 29860056
Mucosal haemorrhage 11.49 10.59 18 92163 1440 29858857
Gastric ulcer 11.44 10.59 18 92163 15103 29845194
Urinary retention 11.40 10.59 153 92028 32764 29827533
Adrenocorticotropic hormone deficiency 11.39 10.59 10 92171 428 29859869
Vein collapse 11.37 10.59 5 92176 59 29860238
Squamous cell carcinoma of skin 11.29 10.59 7 92174 9088 29851209
Orthostatic hypotension 11.26 10.59 37 92144 23942 29836355
Schizophrenia 11.18 10.59 7 92174 9041 29851256
Hepatic enzyme increased 11.17 10.59 59 92122 33435 29826862
Hepatocellular carcinoma 11.12 10.59 8 92173 9602 29850695
Pathogen resistance 11.11 10.59 6 92175 8404 29851893
Drug screen negative 11.11 10.59 8 92173 256 29860041
Polyneuropathy in malignant disease 11.10 10.59 6 92175 114 29860183
Hyperintensity in brain deep nuclei 11.08 10.59 3 92178 6 29860291
Upper gastrointestinal haemorrhage 11.04 10.59 33 92148 21995 29838302
Musculoskeletal stiffness 10.99 10.59 65 92116 35816 29824481
Gynaecomastia 10.97 10.59 6 92175 8345 29851952
Jaundice 10.96 10.59 57 92124 32429 29827868
Dyskinesia 10.93 10.59 109 92072 21725 29838572
Gastrointestinal disorder 10.88 10.59 47 92134 28090 29832207
Product packaging quantity issue 10.82 10.59 12 92169 684 29859613
Procedural hypertension 10.80 10.59 5 92176 67 29860230
Periorbital swelling 10.76 10.59 7 92174 189 29860108
Rash maculo-papular 10.75 10.59 41 92140 25377 29834920
Bile output abnormal 10.68 10.59 4 92177 30 29860267
Apgar score abnormal 10.68 10.59 4 92177 30 29860267
Sopor 10.64 10.59 64 92117 10927 29849370
Salivary hypersecretion 10.60 10.59 5 92176 7561 29852736

Pharmacologic Action:

SourceCodeDescription
ATC N01AH01 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
ATC N01AH51 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
ATC N02AB03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Phenylpiperidine derivatives
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
CHEBI has role CHEBI:35482 narcotic analgesics
CHEBI has role CHEBI:55322 mu opioid agonist
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:38877 intravenous anesthetics
CHEBI has role CHEBI:60807 anaesthesia adjuvants
CHEBI has role CHEBI:60809 adjuvants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
General anesthesia indication 50697003
Local anesthesia indication 386761002
Acute postoperative pain indication 107401000119105
Breakthrough Pain in Opioid Tolerant Patients indication
Chronic Pain with Opioid Tolerance indication
Regional Anesthesia for Surgery indication
Regional Anesthesia for Postoperative Pain indication
Anesthesia for cesarean section off-label use 4847005
Severe pain off-label use 76948002
Conscious sedation off-label use 314271007
Sedation in Intubated Patients off-label use
Regional Anesthesia for Labor Pain off-label use
Alcoholism contraindication 7200002
Cardiomegaly contraindication 8186001
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Decreased cardiac function contraindication 43650005
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Paralytic ileus contraindication 55525008 DOID:8442
Hepatic failure contraindication 59927004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Extrapyramidal disease contraindication 76349003
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of biliary tract contraindication 105997008 DOID:9741
Prolonged QT interval contraindication 111975006
Procedure on urinary system contraindication 118677009
Hypomagnesemia contraindication 190855004
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Headache disorder contraindication 230461009
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Lesion of brain contraindication 301766008
Pheochromocytoma contraindication 302835009
Deficiency of cholinesterase contraindication 360607009
Central nervous system depression contraindication 418072004
Congenital long QT syndrome contraindication 442917000
Acute exacerbation of asthma contraindication 708038006
Pain in Opioid Naive Patients contraindication
Headache Pain especially in Patients who are not Opiate Tolerant contraindication
Refractory Extrinsic Asthma contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST EC50 9.00 WOMBAT-PK CHEMBL
Kappa-type opioid receptor GPCR Ki 6.71 CHEMBL
Delta-type opioid receptor GPCR Ki 6.17 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.74 CHEMBL
Monoamine oxidase Enzyme Ki 5.26 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.71 CHEMBL
Delta-type opioid receptor GPCR IC50 8.03 CHEMBL
Mu-type opioid receptor GPCR Ki 8.07 CHEMBL
Histamine H1 receptor GPCR IC50 4.70 CHEMBL
Opioid receptor GPCR Ki 8.67 CHEMBL
Delta-type opioid receptor GPCR Ki 6.40 CHEMBL
Mu-type opioid receptor GPCR Ki 8.82 CHEMBL
Mu-type opioid receptor GPCR Ki 8.23 CHEMBL

External reference:

IDSource
4018745 VUID
N0000147049 NUI
D00320 KEGG_DRUG
990-73-8 SECONDARY_CAS_RN
4018744 VANDF
4018745 VANDF
C0015846 UMLSCUI
CHEBI:119915 CHEBI
7V7 PDB_CHEM_ID
CHEMBL596 ChEMBL_ID
CHEMBL688 ChEMBL_ID
CHEMBL1201159 ChEMBL_ID
DB00813 DRUGBANK_ID
D005283 MESH_DESCRIPTOR_UI
3345 PUBCHEM_CID
1626 IUPHAR_LIGAND_ID
1608 INN_ID
UF599785JZ UNII
142436 RXNORM
29441 MMSL
4632 MMSL
4721 MMSL
4722 MMSL
64408 MMSL
d00233 MMSL
001568 NDDF
003571 NDDF
011514 NDDF
29190006 SNOMEDCT_US
373492002 SNOMEDCT_US
40648001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7865 LOZENGE 200 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7866 LOZENGE 400 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7867 LOZENGE 600 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7868 LOZENGE 800 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7869 LOZENGE 1200 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7870 LOZENGE 1600 ug ORAL NDA authorized generic 33 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9119 PATCH 12 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9121 PATCH 25 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9122 PATCH 50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9123 PATCH 75 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9124 PATCH 100 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9125 PATCH 37.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9126 PATCH 62.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9127 PATCH 87.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9000 PATCH, EXTENDED RELEASE 100 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9012 PATCH, EXTENDED RELEASE 12.50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9025 PATCH, EXTENDED RELEASE 25 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9037 PATCH, EXTENDED RELEASE 37.50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9050 PATCH, EXTENDED RELEASE 50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9062 PATCH, EXTENDED RELEASE 62.50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9075 PATCH, EXTENDED RELEASE 75 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9100 PATCH, EXTENDED RELEASE 100 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9112 PATCH, EXTENDED RELEASE 12.50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9125 PATCH, EXTENDED RELEASE 25 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9150 PATCH, EXTENDED RELEASE 50 ug TRANSDERMAL ANDA 31 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9175 PATCH, EXTENDED RELEASE 75 ug TRANSDERMAL ANDA 31 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9202 LOZENGE 200 ug TRANSMUCOSAL ANDA 33 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9204 LOZENGE 400 ug TRANSMUCOSAL ANDA 33 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9206 LOZENGE 600 ug TRANSMUCOSAL ANDA 33 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9208 LOZENGE 800 ug TRANSMUCOSAL ANDA 33 sections