fentanyl ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor agonists, analgesics, fentanyl derivatives 1164 437-38-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fentanyl
  • fentanil
  • fentanyl citrate
  • effentora
  • instanyl
  • fentanyl hydrochloride
  • fentanyl HCl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance.
  • Molecular weight: 336.48
  • Formula: C22H28N2O
  • CLOGP: 3.62
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.15
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.60 mg N
0.60 mg SL
1.20 mg TD

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 25 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.89 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.16 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 19, 1968 FDA AKORN
June 29, 2020 PMDA Hisamitsu Pharmaceutical Co., Inc.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2809.21 10.05 1802 127299 58044 50417979
Toxicity to various agents 1029.63 10.05 1898 127203 210601 50265422
Product adhesion issue 687.91 10.05 297 128804 4095 50471928
Respiratory arrest 592.30 10.05 540 128561 29469 50446554
Death 538.37 10.05 1936 127165 323443 50152580
Cardiac arrest 536.94 10.05 848 128253 82803 50393220
Serotonin syndrome 513.86 10.05 458 128643 24255 50451768
Respiratory depression 509.28 10.05 340 128761 11670 50464353
Cardio-respiratory arrest 462.84 10.05 627 128474 53265 50422758
Inadequate analgesia 437.06 10.05 184 128917 2374 50473649
Product quality issue 387.81 10.05 435 128666 30423 50445600
Drug withdrawal syndrome 352.46 10.05 375 128726 24706 50451317
Overdose 342.61 10.05 774 128327 98953 50377070
Incorrect route of product administration 328.04 10.05 315 128786 18351 50457672
Product prescribing error 290.27 10.05 311 128790 20650 50455373
Alopecia 288.81 10.05 132 128969 244915 50231108
Accidental overdose 288.62 10.05 300 128801 19233 50456790
Systemic lupus erythematosus 281.46 10.05 20 129081 140602 50335421
Anaphylactic reaction 278.58 10.05 497 128604 53558 50422465
Intentional product misuse 267.36 10.05 450 128651 46284 50429739
Drug interaction 250.80 10.05 1091 128010 198530 50277493
Synovitis 243.93 10.05 19 129082 123846 50352177
Glossodynia 232.51 10.05 16 129085 115553 50360470
Hand deformity 231.19 10.05 5 129096 100194 50375829
Product complaint 229.39 10.05 208 128893 11258 50464765
Wrong technique in product usage process 213.41 10.05 451 128650 55059 50420964
Maternal exposure during delivery 211.61 10.05 84 129017 922 50475101
Drug dependence 205.72 10.05 253 128848 19506 50456517
Infusion related reaction 204.90 10.05 88 129013 169469 50306554
Arthropathy 195.55 10.05 79 129022 157827 50318196
Hypotension 189.63 10.05 1136 127965 234333 50241690
Apnoea 187.80 10.05 150 128951 6816 50469207
Unresponsive to stimuli 187.48 10.05 304 128797 30305 50445718
Joint swelling 186.05 10.05 211 128890 245075 50230948
Bradycardia 179.15 10.05 461 128640 63965 50412058
Anaesthetic complication 173.83 10.05 86 129015 1644 50474379
Abdominal discomfort 168.43 10.05 206 128895 231435 50244588
Withdrawal syndrome 168.41 10.05 216 128885 17374 50458649
Sinusitis 166.16 10.05 116 128985 170442 50305581
Somnolence 165.52 10.05 808 128293 154177 50321846
Delayed recovery from anaesthesia 162.65 10.05 64 129037 685 50475338
Rash 160.86 10.05 575 128526 436896 50039127
Pericarditis 155.08 10.05 12 129089 78677 50397346
Nasopharyngitis 153.95 10.05 159 128942 192768 50283255
Accidental exposure to product by child 152.01 10.05 67 129034 973 50475050
Miosis 151.47 10.05 127 128974 6183 50469840
Arthralgia 148.07 10.05 597 128504 438105 50037918
Delirium 146.40 10.05 310 128791 37882 50438141
Wound 146.29 10.05 44 129057 105750 50370273
Headache 137.00 10.05 747 128354 505788 49970235
Cough 134.55 10.05 257 128844 241007 50235016
Contraindicated product administered 133.93 10.05 110 128991 148848 50327175
Swelling 133.35 10.05 191 128910 200681 50275342
Procedural hypotension 129.53 10.05 61 129040 1041 50474982
Fatigue 125.91 10.05 1178 127923 706423 49769600
Hyperaesthesia 121.56 10.05 126 128975 8047 50467976
Malignant neoplasm progression 121.11 10.05 416 128685 67708 50408315
Drug intolerance 120.75 10.05 235 128866 218869 50257154
Hepatic enzyme increased 120.36 10.05 104 128997 137276 50338747
Neuromuscular block prolonged 115.68 10.05 45 129056 466 50475557
Application site rash 115.28 10.05 73 129028 2284 50473739
Injection site pain 111.43 10.05 73 129028 110951 50365072
Respiratory rate decreased 110.56 10.05 79 129022 3029 50472994
Treatment failure 110.24 10.05 113 128988 137524 50338499
Depressed level of consciousness 110.19 10.05 337 128764 51616 50424407
Helicobacter infection 109.03 10.05 4 129097 49698 50426325
Myoclonus 108.70 10.05 158 128943 14312 50461711
Lower respiratory tract infection 107.82 10.05 54 129047 95147 50380876
Pleural fibrosis 106.77 10.05 80 129021 3304 50472719
Presbyacusis 104.40 10.05 73 129028 2703 50473320
White blood cell count abnormal 103.57 10.05 96 129005 5344 50470679
Respiratory acidosis 100.76 10.05 99 129002 5929 50470094
Bradypnoea 99.96 10.05 74 129027 3000 50473023
Peripheral swelling 96.09 10.05 242 128859 205694 50270329
Completed suicide 92.08 10.05 614 128487 131275 50344748
Medication error 88.85 10.05 247 128854 35857 50440166
Deafness neurosensory 86.80 10.05 80 129021 4421 50471602
Application site erythema 86.24 10.05 80 129021 4458 50471565
Coma 85.55 10.05 329 128772 56550 50419473
Weight increased 83.90 10.05 251 128850 201640 50274383
Pulmonary oedema 83.63 10.05 295 128806 48643 50427380
Bronchospasm 83.52 10.05 142 128959 14712 50461311
Hypersensitivity 83.44 10.05 276 128825 214885 50261138
Rheumatoid arthritis 83.33 10.05 253 128848 202297 50273726
Pleural thickening 83.24 10.05 62 129039 2537 50473486
Folliculitis 83.23 10.05 4 129097 39221 50436802
Blood magnesium increased 81.89 10.05 64 129037 2816 50473207
Muscle injury 81.35 10.05 3 129098 37108 50438915
Hyperthermia malignant 81.04 10.05 39 129062 700 50475323
Agitation 80.47 10.05 309 128792 53075 50422948
Hypoventilation 78.16 10.05 71 129030 3850 50472173
Irritable bowel syndrome 77.52 10.05 18 129083 51423 50424600
Oxygen saturation decreased 76.02 10.05 379 128722 72869 50403154
Stress cardiomyopathy 75.72 10.05 97 129004 7790 50468233
Labile blood pressure 75.22 10.05 49 129052 1611 50474412
Pulseless electrical activity 75.10 10.05 90 129011 6751 50469272
Circulatory collapse 75.08 10.05 161 128940 19839 50456184
Neoplasm progression 74.25 10.05 202 128899 28955 50447068
Application site vesicles 73.95 10.05 45 129056 1310 50474713
Injection site erythema 72.86 10.05 51 129050 74885 50401138
Application site pruritus 72.85 10.05 67 129034 3692 50472331
Therapeutic product effect incomplete 72.27 10.05 76 129025 91439 50384584
Blood potassium increased 72.20 10.05 141 128960 16257 50459766
Poisoning 71.45 10.05 120 128981 12309 50463714
Abortion spontaneous 70.62 10.05 11 129090 41761 50434262
Hypoxia 69.88 10.05 287 128814 50836 50425187
Sedation 69.08 10.05 203 128898 30407 50445616
Anaphylactic shock 68.60 10.05 156 128945 19999 50456024
Encephalopathy 68.07 10.05 215 128886 33496 50442527
Drug diversion 67.99 10.05 35 129066 730 50475293
Application site reaction 66.22 10.05 33 129068 641 50475382
Pruritus 64.96 10.05 440 128661 283128 50192895
Application site irritation 64.33 10.05 44 129057 1571 50474452
Discomfort 64.30 10.05 111 128990 108269 50367754
Injection site reaction 63.57 10.05 24 129077 50008 50426015
Intercepted product dispensing error 63.53 10.05 19 129082 79 50475944
Product use issue 62.67 10.05 185 128916 149290 50326733
Plasma cell myeloma 62.54 10.05 199 128902 31123 50444900
Device expulsion 60.95 10.05 3 129098 28819 50447204
Epigastric discomfort 60.82 10.05 75 129026 5795 50470228
Urinary retention 60.36 10.05 175 128926 26015 50450008
Fear 60.32 10.05 122 128979 14427 50461596
Ventricular tachycardia 60.12 10.05 128 128973 15693 50460330
Faecaloma 59.88 10.05 82 129019 7026 50468997
Infusion site coldness 59.87 10.05 22 129079 192 50475831
Hypermobility syndrome 59.78 10.05 32 129069 725 50475298
Hip arthroplasty 58.94 10.05 5 129096 30424 50445599
Blood pressure decreased 58.50 10.05 290 128811 55619 50420404
Constipation 57.90 10.05 726 128375 184982 50291041
Knee arthroplasty 57.18 10.05 11 129090 35835 50440188
Respiratory failure 56.83 10.05 413 128688 90768 50385255
Tachycardia 56.62 10.05 442 128659 99321 50376702
Myoglobin urine present 56.60 10.05 25 129076 365 50475658
Drug ineffective 55.95 10.05 1629 127472 817704 49658319
Condition aggravated 55.77 10.05 487 128614 296571 50179452
C-reactive protein abnormal 55.46 10.05 4 129097 27805 50448218
Ill-defined disorder 54.73 10.05 36 129065 54618 50421405
Drug use disorder 54.25 10.05 52 129049 3020 50473003
Drug abuser 54.02 10.05 50 129051 2778 50473245
Multiple organ dysfunction syndrome 53.31 10.05 262 128839 50075 50425948
Gamma-glutamyltransferase decreased 51.89 10.05 22 129079 289 50475734
Muscle rigidity 51.39 10.05 91 129010 9738 50466285
Myalgia 51.28 10.05 155 128946 124164 50351859
Therapeutic product effect increased 51.02 10.05 32 129069 984 50475039
Pain in extremity 50.91 10.05 448 128653 272417 50203606
Therapy naive 50.78 10.05 13 129088 25 50475998
Procedural complication 50.58 10.05 62 129039 4761 50471262
Toxic leukoencephalopathy 50.27 10.05 27 129074 616 50475407
Opiates positive 49.82 10.05 22 129079 321 50475702
Osteopenia 49.58 10.05 124 128977 16894 50459129
Brain oedema 49.24 10.05 102 128999 12268 50463755
Confusional state 48.93 10.05 705 128396 185223 50290800
Application site dermatitis 48.59 10.05 18 129083 161 50475862
Application site pain 48.47 10.05 54 129047 3744 50472279
Therapeutic product effect prolonged 48.46 10.05 21 129080 292 50475731
Allodynia 48.41 10.05 27 129074 665 50475358
Mental status changes 48.28 10.05 202 128899 36070 50439953
Breakthrough pain 47.68 10.05 32 129069 1107 50474916
Influenza 47.56 10.05 98 129003 89440 50386583
Blister 47.51 10.05 91 129010 85327 50390696
Stomatitis 47.28 10.05 119 128982 101225 50374798
Hallucination 46.69 10.05 239 128862 46418 50429605
Generalised tonic-clonic seizure 46.14 10.05 160 128941 26150 50449873
Post procedural complication 46.06 10.05 112 128989 14992 50461031
Vomiting 45.35 10.05 1515 127586 459243 50016780
Bone cyst 45.02 10.05 39 129062 1985 50474038
Vasodilatation 44.90 10.05 41 129060 2238 50473785
Kounis syndrome 44.42 10.05 31 129070 1144 50474879
Anterior spinal artery syndrome 44.40 10.05 14 129087 72 50475951
Restlessness 44.07 10.05 153 128948 25020 50451003
Dependence 43.48 10.05 37 129064 1838 50474185
Neuromuscular blockade 43.41 10.05 19 129082 271 50475752
Asthma 43.17 10.05 103 128998 89234 50386789
Haemodynamic instability 42.87 10.05 75 129026 7949 50468074
Drug screen positive 42.78 10.05 48 129053 3354 50472669
Hyperhidrosis 42.62 10.05 381 128720 89045 50386978
Emotional distress 42.43 10.05 165 128936 28498 50447525
Renal failure 42.28 10.05 437 128664 106196 50369827
Hepatic ischaemia 40.68 10.05 23 129078 582 50475441
Product counterfeit 40.65 10.05 14 129087 99 50475924
Off label use 40.57 10.05 912 128189 473514 50002509
Renal injury 40.31 10.05 76 129025 8535 50467488
General physical health deterioration 39.42 10.05 545 128556 141889 50334134
Loss of consciousness 39.19 10.05 423 128678 103930 50372093
Diarrhoea 38.77 10.05 1175 127926 587301 49888722
Osteosclerosis 38.70 10.05 46 129055 3421 50472602
Disorientation 38.50 10.05 186 128915 35298 50440725
Type 2 diabetes mellitus 38.15 10.05 20 129081 34355 50441668
Bradycardia foetal 37.99 10.05 19 129082 372 50475651
Laryngospasm 37.40 10.05 40 129061 2648 50473375
Unwanted awareness during anaesthesia 37.31 10.05 17 129084 268 50475755
Anhedonia 37.28 10.05 78 129023 9446 50466577
Intentional self-injury 37.06 10.05 7 129094 23105 50452918
Clonus 36.44 10.05 49 129052 4126 50471897
Product dose omission issue 36.42 10.05 297 128804 183541 50292482
Injection site swelling 36.09 10.05 32 129069 41741 50434282
Psoriatic arthropathy 36.07 10.05 40 129061 46992 50429031
Metastases to bone 35.62 10.05 114 128987 17881 50458142
Pulse absent 35.40 10.05 52 129049 4754 50471269
Infusion site induration 35.29 10.05 24 129077 849 50475174
Dehydration 35.04 10.05 565 128536 151884 50324139
Injection site pruritus 34.86 10.05 31 129070 40380 50435643
Dystonia 34.84 10.05 87 129014 11839 50464184
Bronchitis 34.80 10.05 142 128959 104017 50372006
Horner's syndrome 34.60 10.05 9 129092 19 50476004
Endotracheal intubation complication 34.56 10.05 18 129083 385 50475638
Chest discomfort 34.49 10.05 121 128980 92601 50383422
Carcinoid crisis 34.14 10.05 15 129086 216 50475807
Mental status changes postoperative 34.08 10.05 14 129087 169 50475854
Anaesthetic complication neurological 34.01 10.05 14 129087 170 50475853
Altered state of consciousness 33.97 10.05 128 128973 21782 50454241
Product administration error 33.85 10.05 119 128982 19580 50456443
Troponin increased 33.56 10.05 68 129033 8050 50467973
Cauda equina syndrome 33.54 10.05 22 129079 732 50475291
Nasal congestion 33.47 10.05 49 129052 51071 50424952
Product administered at inappropriate site 33.37 10.05 36 129065 2407 50473616
Femoral hernia incarcerated 33.35 10.05 22 129079 739 50475284
Renal impairment 33.34 10.05 317 128784 75344 50400679
Red blood cell sedimentation rate increased 32.82 10.05 17 129084 29399 50446624
Toxic encephalopathy 32.70 10.05 54 129047 5461 50470562
Blood cholesterol increased 32.32 10.05 57 129044 55158 50420865
Airway complication of anaesthesia 32.16 10.05 14 129087 197 50475826
Oropharyngeal pain 32.07 10.05 97 129004 77704 50398319
Pregnancy 31.67 10.05 18 129083 29559 50446464
Palpitations 31.47 10.05 129 128972 94377 50381646
Psoriasis 31.42 10.05 82 129019 68918 50407105
Wound infection pseudomonas 31.33 10.05 26 129075 1247 50474776
Abdominal pain upper 31.26 10.05 258 128843 159051 50316972
Lymphatic fistula 31.22 10.05 21 129080 729 50475294
Herpes zoster 30.82 10.05 86 129015 70700 50405323
Cyanosis 30.79 10.05 97 129004 15087 50460936
Airway peak pressure increased 30.64 10.05 15 129086 280 50475743
Prescription drug used without a prescription 30.44 10.05 29 129072 1671 50474352
Seroma 30.33 10.05 30 129071 1811 50474212
Cancer pain 29.99 10.05 35 129066 2552 50473471
Arachnoid web 29.98 10.05 7 129094 7 50476016
Drug tolerance 29.88 10.05 49 129052 4927 50471096
Wrong product administered 29.81 10.05 51 129050 5309 50470714
Monoplegia 29.55 10.05 36 129065 2747 50473276
Pancreatic steatosis 29.39 10.05 22 129079 907 50475116
Product tampering 28.99 10.05 13 129088 197 50475826
Ocular hyperaemia 28.84 10.05 8 129093 20284 50455739
Arterial haemorrhage 28.72 10.05 27 129074 1530 50474493
Dizziness 28.66 10.05 669 128432 345700 50130323
Product packaging issue 28.61 10.05 22 129079 945 50475078
Procedural hypertension 28.42 10.05 14 129087 265 50475758
Basal cell carcinoma 28.36 10.05 12 129089 23344 50452679
Exposure during pregnancy 28.36 10.05 450 128651 120565 50355458
Gastrooesophageal reflux disease 28.24 10.05 100 129001 76328 50399695
Application site burn 28.24 10.05 20 129081 756 50475267
Hepatorenal syndrome 27.97 10.05 28 129073 1715 50474308
Postoperative delirium 27.97 10.05 10 129091 80 50475943
Anorectal ulcer 27.97 10.05 9 129092 50 50475973
Accidental death 27.96 10.05 28 129073 1716 50474307
Muscle relaxant therapy 27.88 10.05 12 129089 164 50475859
Cyst 27.66 10.05 81 129020 12106 50463917
Local anaesthetic systemic toxicity 27.57 10.05 18 129083 594 50475429
Interstitial lung disease 27.56 10.05 59 129042 53117 50422906
Non-consummation 27.53 10.05 9 129092 53 50475970
Hypoxic-ischaemic encephalopathy 27.48 10.05 41 129060 3801 50472222
Application site perspiration 27.42 10.05 6 129095 3 50476020
Drug hypersensitivity 27.12 10.05 835 128266 250175 50225848
Amylase increased 26.76 10.05 49 129052 5381 50470642
Recurrence of neuromuscular blockade 26.65 10.05 10 129091 93 50475930
C-reactive protein increased 26.60 10.05 84 129017 66390 50409633
Multiple sclerosis relapse 26.39 10.05 43 129058 42921 50433102
Confusion postoperative 26.23 10.05 12 129089 191 50475832
Spinal anaesthesia 25.72 10.05 8 129093 39 50475984
COVID-19 25.69 10.05 50 129051 46612 50429411
Haematemesis 25.66 10.05 139 128962 27586 50448437
Cardiac output decreased 25.59 10.05 20 129081 880 50475143
Breast cancer metastatic 25.58 10.05 71 129030 10293 50465730
Head titubation 25.31 10.05 18 129083 685 50475338
Neurotoxicity 25.29 10.05 89 129012 14651 50461372
Anaesthetic complication pulmonary 25.24 10.05 8 129093 42 50475981
Dyspnoea 25.09 10.05 1142 127959 546466 49929557
Arthritis 24.91 10.05 125 128976 86596 50389427
Cardiogenic shock 24.91 10.05 92 129009 15507 50460516
Hypopnoea 24.90 10.05 30 129071 2263 50473760
Dyspnoea exertional 24.80 10.05 59 129042 51174 50424849
Ventricular fibrillation 24.76 10.05 71 129030 10488 50465535
Tooth loss 24.70 10.05 51 129050 6119 50469904
Rhythm idioventricular 24.58 10.05 11 129090 166 50475857
Poor quality product administered 24.47 10.05 33 129068 2786 50473237
Normal newborn 24.12 10.05 53 129048 6638 50469385
Type I hypersensitivity 23.95 10.05 30 129071 2355 50473668
Upper respiratory tract infection 23.83 10.05 87 129014 65811 50410212
Upper airway obstruction 23.75 10.05 16 129085 557 50475466
Uterine hypertonus 23.63 10.05 12 129089 243 50475780
Ear infection 23.53 10.05 19 129082 25951 50450072
Hepatic failure 23.52 10.05 152 128949 32131 50443892
Visual impairment 23.48 10.05 92 129009 68183 50407840
Pseudopolyp 23.28 10.05 12 129089 251 50475772
Deformity 23.28 10.05 58 129043 7882 50468141
Myotonia 23.21 10.05 10 129091 137 50475886
Pupil fixed 23.21 10.05 24 129077 1528 50474495
Spinal cord injury 23.18 10.05 17 129084 679 50475344
Cerebrovascular accident 23.10 10.05 144 128957 94536 50381487
Spontaneous haemorrhage 23.02 10.05 12 129089 257 50475766
Premature delivery 22.83 10.05 120 128981 23543 50452480
Substance abuse 22.62 10.05 39 129062 4085 50471938
Cachexia 22.46 10.05 41 129060 4492 50471531
Product packaging quantity issue 22.40 10.05 20 129081 1060 50474963
Gastrointestinal disorder 22.36 10.05 145 128956 94311 50381712
Post procedural haemorrhage 22.26 10.05 54 129047 7216 50468807
Coma scale abnormal 22.20 10.05 42 129059 4729 50471294
Gouty tophus 22.16 10.05 10 129091 154 50475869
Sphincter of Oddi dysfunction 22.04 10.05 13 129088 357 50475666
Inflammation 22.02 10.05 73 129028 56839 50419184
Tryptase increased 22.01 10.05 11 129090 215 50475808
Systemic infection 21.79 10.05 28 129073 2255 50473768
Diabetes mellitus 21.77 10.05 59 129042 48974 50427049
Wheezing 21.73 10.05 83 129018 61964 50414059
Lethargy 21.72 10.05 207 128894 49225 50426798
Exposure via ingestion 21.62 10.05 31 129070 2772 50473251
Pituitary apoplexy 21.59 10.05 9 129092 113 50475910
Gastrointestinal scarring 21.56 10.05 11 129090 225 50475798
Rhinorrhoea 21.48 10.05 64 129037 51519 50424504
Dyskinesia 21.43 10.05 133 128968 27728 50448295
Left ventricle outflow tract obstruction 21.21 10.05 11 129090 233 50475790
Dermal absorption impaired 20.94 10.05 5 129096 6 50476017
Cataract 20.94 10.05 57 129044 47243 50428780
Musculoskeletal disorder 20.93 10.05 9 129092 17340 50458683
Supraventricular tachycardia 20.86 10.05 76 129025 12725 50463298
Potentiating drug interaction 20.82 10.05 36 129065 3780 50472243
Acute postoperative sialadenitis 20.66 10.05 6 129095 22 50476001
Apnoeic attack 20.36 10.05 11 129090 254 50475769
Anticholinergic syndrome 20.34 10.05 24 129077 1771 50474252
Tachyarrhythmia 20.18 10.05 37 129064 4068 50471955
Fibromyalgia 20.06 10.05 54 129047 44924 50431099
Transient ischaemic attack 20.00 10.05 32 129069 32178 50443845
Vascular resistance systemic decreased 19.90 10.05 8 129093 91 50475932
Exposure to extreme temperature 19.90 10.05 4 129097 0 50476023
Throat irritation 19.78 10.05 29 129072 30210 50445813
Injection site bruising 19.72 10.05 40 129061 36728 50439295
Mean arterial pressure decreased 19.69 10.05 9 129092 143 50475880
Hypovolaemia 19.68 10.05 61 129040 9404 50466619
Skin sensitisation 19.65 10.05 16 129085 747 50475276
Ankylosing spondylitis 19.61 10.05 51 129050 7114 50468909
Atrioventricular block second degree 19.54 10.05 34 129067 3587 50472436
Methaemoglobinaemia 19.42 10.05 25 129076 2017 50474006
Progressive multifocal leukoencephalopathy 19.40 10.05 3 129098 11454 50464569
Haemarthrosis 19.34 10.05 30 129071 2878 50473145
Mobility decreased 19.29 10.05 122 128979 79826 50396197
Nephrolithiasis 19.25 10.05 37 129064 34656 50441367
Contusion 19.23 10.05 188 128913 111995 50364028
Post-traumatic neck syndrome 19.14 10.05 24 129077 1886 50474137
Hypercreatininaemia 19.13 10.05 12 129089 369 50475654
Nausea 19.09 10.05 2066 127035 703332 49772691
Eye irritation 18.98 10.05 10 129091 17130 50458893
Hyperreflexia 18.98 10.05 41 129060 5077 50470946
Diabetic ketoacidosis 18.96 10.05 11 129090 17861 50458162
Vasoconstriction 18.53 10.05 13 129088 484 50475539
Hypertonia 18.51 10.05 35 129066 3938 50472085
Mean arterial pressure increased 18.50 10.05 5 129096 13 50476010
Anaphylactoid reaction 18.41 10.05 32 129069 3374 50472649
Cardiac failure congestive 18.25 10.05 133 128968 84249 50391774
Hypercapnia 18.23 10.05 38 129063 4589 50471434
Opisthotonus 18.14 10.05 11 129090 318 50475705
Vaginal flatulence 18.09 10.05 10 129091 242 50475781
Joint stiffness 18.00 10.05 31 129070 30277 50445746
Generalised onset non-motor seizure 17.98 10.05 5 129096 15 50476008
Female genital tract fistula 17.96 10.05 33 129068 3633 50472390
Spinal epidural haematoma 17.96 10.05 17 129084 972 50475051
Application site erosion 17.91 10.05 9 129092 178 50475845
Retinopathy of prematurity 17.90 10.05 11 129090 326 50475697
Retinal detachment 17.79 10.05 40 129061 5089 50470934
Osteoporosis 17.75 10.05 57 129044 44822 50431201
Anaesthetic complication cardiac 17.73 10.05 5 129096 16 50476007
Intestinal pseudo-obstruction 17.73 10.05 15 129086 739 50475284
Gram stain positive 17.72 10.05 6 129095 40 50475983
Postpartum haemorrhage 17.51 10.05 22 129079 1732 50474291
Drug screen negative 17.44 10.05 10 129091 260 50475763
Facial nerve disorder 17.43 10.05 13 129088 533 50475490
Stridor 17.42 10.05 30 129071 3139 50472884
Tenosynovitis 17.37 10.05 3 129098 10562 50465461
Heavy menstrual bleeding 17.30 10.05 9 129092 15528 50460495
Paraplegia 17.28 10.05 26 129075 2428 50473595
Respiratory distress 17.23 10.05 135 128966 30354 50445669
Infection 17.23 10.05 324 128777 172630 50303393
Manufacturing production issue 17.13 10.05 4 129097 4 50476019
Injection site warmth 17.04 10.05 7 129094 13859 50462164
Therapeutic response unexpected 16.96 10.05 83 129018 15832 50460191
Productive cough 16.87 10.05 73 129028 52621 50423402
Sepsis 16.76 10.05 451 128650 132474 50343549
Disturbance in social behaviour 16.71 10.05 28 129073 2866 50473157
Electrocardiogram ST segment elevation 16.69 10.05 31 129070 3442 50472581
Posturing 16.59 10.05 12 129089 469 50475554
Vein disorder 16.47 10.05 35 129066 4284 50471739
Dental caries 16.43 10.05 59 129042 9808 50466215
Mydriasis 16.40 10.05 62 129039 10565 50465458
Listless 16.38 10.05 25 129076 2365 50473658
Decorticate posture 16.37 10.05 10 129091 293 50475730
Pancreatic carcinoma metastatic 16.37 10.05 23 129078 2019 50474004
Post laminectomy syndrome 16.31 10.05 9 129092 217 50475806
Metabolic acidosis 16.28 10.05 161 128940 38664 50437359
Blood pressure immeasurable 16.28 10.05 17 129084 1095 50474928
Tracheal deviation 16.26 10.05 6 129095 53 50475970
Procedural nausea 16.24 10.05 14 129087 708 50475315
Abscess neck 16.23 10.05 13 129088 593 50475430
Metastatic neoplasm 16.18 10.05 32 129069 3722 50472301
Bulimia nervosa 16.00 10.05 11 129090 396 50475627
Oculogyric crisis 15.93 10.05 19 129082 1418 50474605
Documented hypersensitivity to administered product 15.90 10.05 12 129089 501 50475522
Balance disorder 15.88 10.05 110 128991 70480 50405543
Accidental exposure to product 15.85 10.05 107 128994 22950 50453073
Sneezing 15.84 10.05 8 129093 14036 50461987
Acute respiratory distress syndrome 15.78 10.05 100 129001 20999 50455024
Mastocytosis 15.78 10.05 12 129089 507 50475516
Injection site rash 15.73 10.05 11 129090 16166 50459857
Fluid retention 15.71 10.05 71 129030 50578 50425445
Ileus paralytic 15.66 10.05 33 129068 4017 50472006
Brain injury 15.64 10.05 42 129059 5972 50470051
Vitamin K deficiency 15.62 10.05 11 129090 412 50475611
Pneumothorax 15.54 10.05 74 129027 13960 50462063
Postmortem blood drug level 15.50 10.05 7 129094 108 50475915
Paralysis 15.46 10.05 53 129048 8611 50467412
Radiculopathy 15.45 10.05 37 129064 4904 50471119
Gaze palsy 15.40 10.05 18 129083 1315 50474708
Therapeutic response decreased 15.39 10.05 65 129036 47166 50428857
Cancer fatigue 15.36 10.05 5 129096 29 50475994
Loss of personal independence in daily activities 15.35 10.05 110 128991 69940 50406083
Coagulopathy 15.30 10.05 88 129013 17856 50458167
Drug specific antibody 15.29 10.05 21 129080 1804 50474219
Oxygen saturation immeasurable 15.20 10.05 4 129097 9 50476014
Tooth hypoplasia 15.18 10.05 6 129095 65 50475958
Joint injury 15.15 10.05 20 129081 21769 50454254
Blood glucose increased 15.15 10.05 113 128988 71211 50404812
Drug eruption 15.09 10.05 23 129078 23583 50452440
Decerebrate posture 15.05 10.05 7 129094 116 50475907
Tachyphylaxis 15.01 10.05 9 129092 255 50475768
Gastrointestinal mucosa hyperaemia 14.99 10.05 8 129093 180 50475843
Myocardial ischaemia 14.93 10.05 64 129037 11549 50464474
Peroneal nerve palsy postoperative 14.92 10.05 3 129098 0 50476023
Fungal infection 14.91 10.05 34 129067 29931 50446092
Tumour pain 14.86 10.05 17 129084 1213 50474810
Intervertebral disc compression 14.73 10.05 15 129086 938 50475085
Sensitivity to weather change 14.70 10.05 41 129060 5960 50470063
Quadriplegia 14.70 10.05 20 129081 1703 50474320
Procedural vomiting 14.66 10.05 11 129090 455 50475568
Nystagmus 14.63 10.05 39 129062 5522 50470501
Uveitis 14.55 10.05 3 129098 9307 50466716
Limb discomfort 14.38 10.05 25 129076 24332 50451691
Reduced facial expression 14.36 10.05 19 129082 1575 50474448
Tuberculosis 14.28 10.05 4 129097 10079 50465944
Liver disorder 14.22 10.05 48 129053 37174 50438849
Apathy 14.20 10.05 47 129054 7501 50468522
Wound dehiscence 14.16 10.05 33 129068 4297 50471726
Cardiac massage 14.14 10.05 4 129097 13 50476010
Oesophageal intramural haematoma 14.14 10.05 6 129095 79 50475944
Mean cell haemoglobin decreased 13.93 10.05 28 129073 3295 50472728
Karnofsky scale worsened 13.92 10.05 4 129097 14 50476009
Resuscitation 13.87 10.05 15 129086 1006 50475017
Foetal heart rate decreased 13.86 10.05 7 129094 140 50475883
Ventricular hypokinesia 13.76 10.05 31 129070 3949 50472074
Product storage error 13.73 10.05 7 129094 12217 50463806
Atrioventricular dissociation 13.62 10.05 8 129093 218 50475805
Depressed mood 13.60 10.05 43 129058 33980 50442043
Brain death 13.57 10.05 25 129076 2758 50473265
Caesarean section 13.53 10.05 77 129024 15562 50460461
Air embolism 13.52 10.05 8 129093 221 50475802
Eye swelling 13.49 10.05 19 129082 20125 50455898
Carpal tunnel syndrome 13.36 10.05 14 129087 16879 50459144
Substance use disorder 13.32 10.05 6 129095 92 50475931
Amphetamines positive 13.22 10.05 7 129094 155 50475868
Yawning 13.19 10.05 14 129087 919 50475104
Acute lung injury 13.16 10.05 17 129084 1376 50474647
Laryngeal stenosis 13.15 10.05 13 129088 784 50475239
Bezold-Jarisch reflex 13.12 10.05 4 129097 18 50476005
Counterfeit product administered 13.12 10.05 4 129097 18 50476005
Self-medication 12.95 10.05 22 129079 2277 50473746
Spinal cord infarction 12.90 10.05 8 129093 241 50475782
Pancreatic carcinoma 12.88 10.05 40 129061 6174 50469849
Acute respiratory failure 12.88 10.05 121 128980 28661 50447362
Nerve stimulation test abnormal 12.85 10.05 3 129098 3 50476020
Torsade de pointes 12.81 10.05 62 129039 11773 50464250
Eczema 12.78 10.05 24 129077 22678 50453345
Phrenic nerve paralysis 12.71 10.05 6 129095 103 50475920
Orthostatic hypotension 12.69 10.05 36 129065 29445 50446578
Non-small cell lung cancer 12.62 10.05 25 129076 2912 50473111
Rash pruritic 12.60 10.05 71 129030 47775 50428248
Therapeutic product effect decreased 12.59 10.05 258 128843 135792 50340231
Ear pain 12.58 10.05 34 129067 28249 50447774
Periorbital cellulitis 12.53 10.05 11 129090 570 50475453
Paranoia 12.52 10.05 56 129045 10292 50465731
Urticaria 12.50 10.05 244 128857 129317 50346706
Macular degeneration 12.45 10.05 11 129090 14377 50461646
Aortic valve stenosis 12.39 10.05 25 129076 2950 50473073
Impaired healing 12.36 10.05 116 128985 69670 50406353
Laryngeal obstruction 12.35 10.05 6 129095 110 50475913
Hemianopia homonymous 12.34 10.05 11 129090 582 50475441
Procedural haemorrhage 12.33 10.05 22 129079 2368 50473655
Arteriospasm coronary 12.32 10.05 27 129074 3375 50472648
Implant site extravasation 12.32 10.05 10 129091 465 50475558
Performance status decreased 12.31 10.05 26 129075 3169 50472854
Coagulation time prolonged 12.22 10.05 15 129086 1153 50474870
Blood ethanol increased 12.21 10.05 6 129095 113 50475910
Blood creatinine decreased 12.19 10.05 34 129067 4942 50471081
Chorea 12.11 10.05 16 129085 1324 50474699
Myelosuppression 12.11 10.05 10 129091 13507 50462516
Uterine atony 12.11 10.05 7 129094 185 50475838
Perfume sensitivity 12.10 10.05 11 129090 597 50475426
Eye pain 12.06 10.05 35 129066 28414 50447609
Metastatic gastric cancer 12.02 10.05 6 129095 117 50475906
Somatosensory evoked potentials abnormal 11.99 10.05 3 129098 5 50476018
Dyspepsia 11.94 10.05 126 128975 73971 50402052
Viral infection 11.92 10.05 38 129063 29948 50446075
Hypermagnesaemia 11.91 10.05 13 129088 881 50475142
Streptococcal sepsis 11.90 10.05 18 129083 1689 50474334
Sputum discoloured 11.89 10.05 10 129091 13385 50462638
Laryngeal oedema 11.87 10.05 34 129067 5019 50471004
Sinus disorder 11.78 10.05 18 129083 18440 50457583
Propofol infusion syndrome 11.73 10.05 12 129089 754 50475269
Narcotic bowel syndrome 11.70 10.05 6 129095 124 50475899
Lagophthalmos 11.69 10.05 8 129093 286 50475737
Malaise 11.67 10.05 719 128382 334813 50141210
Application site laceration 11.64 10.05 3 129098 6 50476017
Central-alveolar hypoventilation 11.64 10.05 3 129098 6 50476017
Lumbosacral plexopathy 11.64 10.05 3 129098 6 50476017
Hypertension 11.63 10.05 431 128670 210772 50265251
Underdose 11.57 10.05 90 129011 20188 50455835
Euthyroid sick syndrome 11.57 10.05 5 129096 69 50475954
Bronchiectasis 11.38 10.05 6 129095 10277 50465746
Hypotonia 11.37 10.05 46 129055 8088 50467935
Acute chest syndrome 11.37 10.05 11 129090 646 50475377
Feeling cold 11.32 10.05 87 129014 19444 50456579
Incontinence 11.31 10.05 53 129048 9932 50466091
Infection parasitic 11.30 10.05 8 129093 302 50475721
Visceral congestion 11.26 10.05 8 129093 304 50475719
Vasoplegia syndrome 11.17 10.05 14 129087 1100 50474923
Product formulation issue 11.12 10.05 10 129091 535 50475488
Hypersomnia 11.09 10.05 72 129029 15242 50460781
Unevaluable event 11.04 10.05 172 128929 45894 50430129
Conjunctivitis 11.04 10.05 15 129086 16130 50459893
Vision blurred 11.01 10.05 138 128963 78509 50397514
Cytomegalovirus infection 11.01 10.05 18 129083 17944 50458079
Septic shock 10.99 10.05 206 128895 56969 50419054
Gastrointestinal vascular malformation 10.98 10.05 4 129097 34 50475989
Dysaesthesia pharynx 10.97 10.05 6 129095 142 50475881
Panniculitis 10.93 10.05 4 129097 8499 50467524
Atrioventricular block complete 10.93 10.05 42 129059 7213 50468810
Pain 10.91 10.05 1302 127799 577601 49898422
Liver injury 10.90 10.05 30 129071 24776 50451247
Ventricular dysfunction 10.89 10.05 22 129079 2599 50473424
Grip strength decreased 10.82 10.05 9 129092 12112 50463911
Obstetric procedure complication 10.79 10.05 3 129098 9 50476014
Excessive dynamic airway collapse 10.79 10.05 3 129098 9 50476014
Hypobarism 10.79 10.05 3 129098 9 50476014
Acne 10.78 10.05 21 129080 19574 50456449
Femur fracture 10.75 10.05 54 129047 37410 50438613
Therapy interrupted 10.74 10.05 22 129079 20130 50455893
Premature separation of placenta 10.73 10.05 17 129084 1661 50474362
Prinzmetal angina 10.72 10.05 11 129090 694 50475329
Ileus 10.71 10.05 64 129037 13165 50462858
Blood albumin decreased 10.69 10.05 64 129037 13172 50462851
Myocardial depression 10.68 10.05 9 129092 441 50475582
Harlequin syndrome 10.68 10.05 4 129097 37 50475986
Head and neck cancer 10.68 10.05 4 129097 37 50475986
Middle insomnia 10.68 10.05 6 129095 9915 50466108
Burkholderia test positive 10.67 10.05 7 129094 233 50475790
Psychomotor skills impaired 10.65 10.05 19 129082 2045 50473978
Metabolic encephalopathy 10.64 10.05 33 129068 5088 50470935
Multiple lentigines syndrome 10.61 10.05 6 129095 152 50475871
Paroxysmal arrhythmia 10.59 10.05 4 129097 38 50475985
Metastatic malignant melanoma 10.59 10.05 14 129087 1160 50474863
Sinus congestion 10.58 10.05 12 129089 13959 50462064
Platelet disorder 10.58 10.05 16 129085 1501 50474522
Sinus arrest 10.58 10.05 17 129084 1681 50474342
Non-cardiogenic pulmonary oedema 10.57 10.05 10 129091 571 50475452
Respiratory paralysis 10.55 10.05 3 129098 10 50476013
Osteomyelitis 10.52 10.05 95 129006 22258 50453765
Gestational diabetes 10.50 10.05 3 129098 7462 50468561
Chest expansion decreased 10.50 10.05 4 129097 39 50475984
Muscle spasms 10.49 10.05 242 128859 125311 50350712
Neurosis 10.48 10.05 7 129094 240 50475783
Memory impairment 10.46 10.05 141 128960 79219 50396804
Pneumonia aspiration 10.41 10.05 123 128978 30881 50445142
Shock 10.36 10.05 89 129012 20561 50455462
Postoperative wound infection 10.35 10.05 46 129055 8429 50467594
Gastroenteritis 10.34 10.05 28 129073 23253 50452770
Incorrect product administration duration 10.33 10.05 49 129052 9226 50466797
Intensive care unit delirium 10.32 10.05 4 129097 41 50475982
Colon cancer metastatic 10.31 10.05 13 129088 1027 50474996
Status epilepticus 10.31 10.05 64 129037 13342 50462681
Hypothermia 10.29 10.05 59 129042 11957 50464066
Troponin I increased 10.29 10.05 18 129083 1908 50474115
Inappropriate antidiuretic hormone secretion 10.27 10.05 11 129090 13132 50462891
Proctitis 10.27 10.05 18 129083 1910 50474113
Epistaxis 10.20 10.05 109 128992 63845 50412178
Embolic cerebral infarction 10.18 10.05 9 129092 471 50475552
Sinus tachycardia 10.17 10.05 91 129010 21263 50454760
Pelvic fracture 10.15 10.05 57 129044 11463 50464560
Hyperresponsive to stimuli 10.15 10.05 4 129097 43 50475980
Endometriosis 10.14 10.05 28 129073 4047 50471976
Chemical peritonitis 10.09 10.05 5 129096 96 50475927
Intestinal ischaemia 10.08 10.05 39 129062 6718 50469305
Transplant rejection 10.07 10.05 6 129095 9603 50466420
Subcutaneous emphysema 10.07 10.05 11 129090 746 50475277
Eosinophil cationic protein increased 10.07 10.05 4 129097 44 50475979

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 6845.19 11.00 3919 97594 75964 29397050
Toxicity to various agents 2087.89 11.00 2759 98754 170902 29302112
Respiratory arrest 658.35 11.00 611 100902 25222 29447792
Accidental overdose 631.00 11.00 506 101007 17087 29455927
Incorrect route of product administration 598.69 11.00 404 101109 10397 29462617
Cardio-respiratory arrest 577.69 11.00 787 100726 49814 29423200
Overdose 537.80 11.00 974 100539 78845 29394169
Serotonin syndrome 528.89 11.00 456 101057 17056 29455958
Cardiac arrest 499.15 11.00 982 100531 84609 29388405
Product adhesion issue 490.03 11.00 186 101327 1285 29471729
Respiratory depression 480.72 11.00 387 101126 13136 29459878
Intentional product misuse 337.55 11.00 500 101013 34161 29438853
Drug withdrawal syndrome 302.22 11.00 340 101173 17644 29455370
Hyperthermia malignant 279.53 11.00 132 101381 1652 29471362
Drug dependence 249.26 11.00 333 101180 20648 29452366
Miosis 232.52 11.00 204 101309 7805 29465209
Unresponsive to stimuli 231.08 11.00 353 101160 24773 29448241
Depressed level of consciousness 217.48 11.00 426 101087 36516 29436498
Anaphylactic reaction 201.39 11.00 349 101164 27224 29445790
Inadequate analgesia 201.13 11.00 121 101392 2533 29470481
Accidental exposure to product by child 190.34 11.00 93 101420 1261 29471753
Death 182.54 11.00 1882 99631 340202 29132812
Pulmonary oedema 168.88 11.00 420 101093 42315 29430699
Product quality issue 159.98 11.00 233 101280 15662 29457352
Hyperaesthesia 157.76 11.00 115 101398 3354 29469660
Delirium 141.98 11.00 374 101139 39023 29433991
Somnolence 134.28 11.00 658 100855 93297 29379717
Anaesthetic complication 127.54 11.00 64 101449 922 29472092
Delayed recovery from anaesthesia 117.91 11.00 55 101458 668 29472346
Neoplasm progression 117.29 11.00 221 101292 18391 29454623
Product prescribing error 113.96 11.00 214 101299 17762 29455252
Malignant neoplasm progression 108.88 11.00 522 100991 73337 29399677
Apnoea 103.55 11.00 116 101397 5986 29467028
Headache 103.38 11.00 283 101230 173724 29299290
Withdrawal syndrome 101.81 11.00 155 101358 10837 29462177
Wrong technique in product usage process 100.89 11.00 286 101227 31142 29441872
Injury 100.54 11.00 210 101303 18836 29454178
Brain oedema 100.27 11.00 163 101350 12057 29460957
Product complaint 93.86 11.00 104 101409 5301 29467713
Fear 92.27 11.00 137 101376 9367 29463647
Drug use disorder 91.06 11.00 83 101430 3339 29469675
Arthralgia 88.28 11.00 220 101293 139397 29333617
Diarrhoea 86.16 11.00 730 100783 331968 29141046
Neuromuscular block prolonged 84.22 11.00 38 101475 425 29472589
Rash 82.64 11.00 353 101160 189466 29283548
Pruritus 82.03 11.00 174 101339 116675 29356339
Bradypnoea 78.21 11.00 65 101448 2306 29470708
Anaphylactic shock 77.46 11.00 153 101360 13183 29459831
Amnestic disorder 76.80 11.00 28 101485 170 29472844
Respiratory rate decreased 74.08 11.00 58 101455 1887 29471127
Cough 73.78 11.00 208 101305 126519 29346495
Counterfeit product administered 72.71 11.00 26 101487 148 29472866
Muscle rigidity 72.46 11.00 122 101391 9289 29463725
Drug interaction 72.14 11.00 1012 100501 196373 29276641
Intensive care unit acquired weakness 71.47 11.00 43 101470 900 29472114
Respiratory acidosis 71.26 11.00 81 101432 4247 29468767
Sedation complication 71.11 11.00 48 101465 1234 29471780
Drug abuser 70.56 11.00 76 101437 3751 29469263
Cardiac failure congestive 69.30 11.00 97 101416 76484 29396530
Myalgia 68.74 11.00 92 101421 73927 29399087
Renal injury 67.85 11.00 124 101389 10078 29462936
Post procedural complication 67.49 11.00 125 101388 10264 29462750
Anhedonia 67.34 11.00 102 101411 7098 29465916
Myoclonus 67.06 11.00 144 101369 13165 29459849
Propofol infusion syndrome 66.92 11.00 39 101474 768 29472246
Brain injury 64.68 11.00 87 101426 5425 29467589
Emotional distress 63.97 11.00 145 101368 13750 29459264
Hypotension 62.96 11.00 976 100537 193378 29279636
Treatment failure 62.90 11.00 24 101489 36915 29436099
Product counterfeit 62.46 11.00 22 101491 119 29472895
Drug diversion 61.35 11.00 37 101476 778 29472236
Fatigue 60.14 11.00 748 100765 316073 29156941
Narcotic bowel syndrome 58.66 11.00 21 101492 120 29472894
Procedural hypotension 58.35 11.00 37 101476 853 29472161
Coma 57.48 11.00 278 101235 39172 29433842
Pulseless electrical activity 57.15 11.00 89 101424 6345 29466669
Coronary artery disease 57.10 11.00 41 101472 44149 29428865
Hypercapnia 56.76 11.00 67 101446 3659 29469355
Myocardial infarction 56.40 11.00 192 101321 110104 29362910
Nasopharyngitis 55.55 11.00 74 101439 59591 29413423
Off label use 55.26 11.00 715 100798 300085 29172929
Peripheral swelling 54.46 11.00 84 101429 63655 29409359
Cyanosis 53.46 11.00 119 101394 11148 29461866
Weight increased 53.07 11.00 115 101398 76552 29396462
Prescription drug used without a prescription 52.09 11.00 40 101473 1264 29471750
Hypoxia 52.08 11.00 309 101204 47070 29425944
Intentional product use issue 51.85 11.00 285 101228 42213 29430801
Bradycardia 51.12 11.00 393 101120 65236 29407778
Opiates positive 50.77 11.00 28 101485 494 29472520
Procedural complication 50.59 11.00 66 101447 3994 29469020
Product dose omission issue 50.49 11.00 166 101347 96217 29376797
Blood glucose increased 50.14 11.00 78 101435 58906 29414108
Medication error 48.72 11.00 172 101341 21039 29451975
Asthma 48.38 11.00 28 101485 33821 29439193
Dyspnoea exertional 48.28 11.00 33 101480 36457 29436557
Syncope 46.99 11.00 134 101379 81237 29391777
Anion gap 46.76 11.00 30 101483 706 29472308
Hypoxic-ischaemic encephalopathy 46.32 11.00 65 101448 4219 29468795
Febrile neutropenia 46.18 11.00 213 101300 112027 29360987
Laryngospasm 45.98 11.00 37 101476 1253 29471761
Compartment syndrome 45.75 11.00 49 101464 2403 29470611
Oxygen saturation decreased 45.54 11.00 287 101226 44650 29428364
Arthritis 44.73 11.00 15 101498 25004 29448010
Spinal muscular atrophy 44.24 11.00 21 101492 266 29472748
Pain 44.21 11.00 830 100683 170602 29302412
Exposure to toxic agent 43.77 11.00 49 101464 2526 29470488
Infusion related reaction 43.38 11.00 52 101461 43834 29429180
Application site reaction 42.46 11.00 23 101490 391 29472623
Tachypnoea 42.25 11.00 131 101382 14984 29458030
Agitation 42.07 11.00 311 101202 50993 29422021
Sinusitis 41.66 11.00 34 101479 34316 29438698
Dyspnoea 41.19 11.00 833 100680 325899 29147115
Blood pressure measurement 40.53 11.00 17 101496 157 29472857
Drug tolerance 40.12 11.00 43 101470 2110 29470904
Rheumatoid arthritis 40.03 11.00 31 101482 32121 29440893
Dizziness 39.28 11.00 439 101074 189245 29283769
Blood cholesterol increased 39.17 11.00 4 101509 15591 29457423
Accidental death 38.94 11.00 42 101471 2076 29470938
Malaise 38.56 11.00 356 101157 159246 29313768
Tachycardia 38.52 11.00 399 101114 72011 29401003
Tryptase increased 38.25 11.00 17 101496 183 29472831
Respiratory failure 38.23 11.00 505 101008 96626 29376388
Cerebrovascular accident 37.87 11.00 136 101377 76775 29396239
Poisoning 37.12 11.00 96 101417 9897 29463117
Negative pressure pulmonary oedema 36.48 11.00 17 101496 206 29472808
Hypoglycaemia 36.44 11.00 69 101444 48277 29424737
Confusional state 36.42 11.00 629 100884 127248 29345766
Airway complication of anaesthesia 36.00 11.00 15 101498 136 29472878
Anaesthetic complication neurological 35.98 11.00 19 101494 306 29472708
Pain in extremity 35.78 11.00 227 101286 110206 29362808
Psoriasis 35.37 11.00 35 101478 32192 29440822
Tachyphylaxis 34.85 11.00 13 101500 85 29472929
Haemodynamic instability 34.69 11.00 82 101431 7991 29465023
Increased bronchial secretion 33.82 11.00 34 101479 1547 29471467
Coma blister 33.60 11.00 12 101501 68 29472946
Hypoventilation 33.57 11.00 45 101468 2796 29470218
Blood pressure decreased 33.56 11.00 269 101244 45208 29427806
Cytomegalovirus infection 33.46 11.00 19 101494 23196 29449818
Drug resistance 33.46 11.00 16 101497 21524 29451490
Angina pectoris 33.24 11.00 28 101485 27822 29445192
Sedation 33.21 11.00 133 101380 17272 29455742
Cardiac failure 32.87 11.00 150 101363 79137 29393877
Drug detoxification 32.84 11.00 15 101498 173 29472841
Diabetes mellitus 32.59 11.00 54 101459 39777 29433237
Unevaluable event 32.35 11.00 194 101319 29657 29443357
Anterograde amnesia 31.97 11.00 14 101499 145 29472869
Pyrexia 31.95 11.00 748 100765 286874 29186140
Brain death 31.85 11.00 40 101473 2330 29470684
Application site rash 31.76 11.00 24 101489 740 29472274
Upper airway obstruction 31.65 11.00 22 101491 594 29472420
Constipation 31.59 11.00 559 100954 113601 29359413
Therapeutic product effect increased 31.52 11.00 22 101491 598 29472416
Gastrointestinal haemorrhage 31.48 11.00 153 101360 79380 29393634
Joint swelling 31.46 11.00 78 101435 49552 29423462
Pulmonary congestion 31.32 11.00 104 101409 12332 29460682
Eosinophilia 30.73 11.00 19 101494 22142 29450872
Epistaxis 30.68 11.00 84 101429 51620 29421394
Recurrence of neuromuscular blockade 30.53 11.00 13 101500 125 29472889
Injection site pain 30.44 11.00 40 101473 32406 29440608
Bronchospasm 30.38 11.00 87 101426 9522 29463492
Neuropathy peripheral 30.26 11.00 133 101380 70894 29402120
Chest discomfort 30.15 11.00 71 101442 45912 29427102
Toxic leukoencephalopathy 29.91 11.00 16 101497 265 29472749
Diabetic ketoacidosis 29.86 11.00 9 101504 16064 29456950
Oxygen saturation immeasurable 29.72 11.00 9 101504 27 29472987
Gait disturbance 29.67 11.00 140 101373 73209 29399805
Influenza 29.65 11.00 62 101451 41819 29431195
Fall 29.60 11.00 429 101084 176749 29296265
Disorientation 29.58 11.00 188 101325 29327 29443687
International normalised ratio increased 29.51 11.00 68 101445 44304 29428710
Coma scale abnormal 29.45 11.00 47 101466 3422 29469592
Breakthrough pain 29.16 11.00 20 101493 528 29472486
Hyperhidrosis 28.99 11.00 344 101169 64196 29408818
Acute motor axonal neuropathy 28.87 11.00 10 101503 51 29472963
Basal cell carcinoma 28.76 11.00 11 101502 16899 29456115
Autonomic nervous system imbalance 28.64 11.00 38 101475 2338 29470676
Clonus 28.61 11.00 38 101475 2340 29470674
Postoperative ileus 28.61 11.00 21 101492 619 29472395
Rectal haemorrhage 28.11 11.00 47 101466 34502 29438512
Blood pressure increased 28.04 11.00 144 101369 73659 29399355
Resuscitation 27.66 11.00 27 101486 1185 29471829
Loss of personal independence in daily activities 27.49 11.00 28 101485 25412 29447602
Drug withdrawal syndrome neonatal 27.46 11.00 45 101468 3350 29469664
Trigemino-cardiac reflex 27.29 11.00 13 101500 166 29472848
Nephrolithiasis 27.25 11.00 28 101485 25306 29447708
Haemoglobin decreased 26.90 11.00 240 101273 108135 29364879
Seizure like phenomena 26.77 11.00 20 101493 606 29472408
Conversion disorder 26.67 11.00 16 101497 333 29472681
Bone marrow failure 26.62 11.00 33 101480 27416 29445598
Myocardial stunning 26.57 11.00 7 101506 10 29473004
Therapy naive 26.57 11.00 7 101506 10 29473004
Product use in unapproved indication 26.40 11.00 182 101331 86693 29386321
Product administered at inappropriate site 26.32 11.00 31 101482 1689 29471325
Pancreatitis acute 26.17 11.00 27 101486 24358 29448656
Abdominal discomfort 26.11 11.00 81 101432 47822 29425192
Plasma cell myeloma 26.01 11.00 217 101296 36898 29436116
Acute lung injury 25.51 11.00 27 101486 1306 29471708
Sinus tachycardia 25.50 11.00 111 101402 14958 29458056
Accidental exposure to product 25.38 11.00 88 101425 10665 29462349
Self-medication 25.27 11.00 34 101479 2120 29470894
Metabolic acidosis 25.23 11.00 218 101295 37444 29435570
Hypopnoea 25.07 11.00 26 101487 1228 29471786
Pneumococcal sepsis 25.01 11.00 22 101491 844 29472170
Tooth loss 24.86 11.00 45 101468 3629 29469385
Transient ischaemic attack 24.71 11.00 26 101487 23244 29449770
Pelvic pain 24.67 11.00 33 101480 2046 29470968
Post procedural hypotension 24.64 11.00 9 101504 55 29472959
Suicide attempt 24.56 11.00 50 101463 34060 29438954
Application site pruritus 24.34 11.00 26 101487 1271 29471743
Accidental poisoning 24.25 11.00 18 101495 540 29472474
Postmortem blood drug level increased 24.16 11.00 13 101500 218 29472796
Thermophobia 24.10 11.00 9 101504 59 29472955
Urinary tract infection 23.79 11.00 148 101365 72206 29400808
Oculocardiac reflex 23.73 11.00 9 101504 62 29472952
Arteriospasm coronary 23.51 11.00 36 101477 2529 29470485
Herpes zoster 23.43 11.00 42 101471 30010 29443004
Palpitations 23.30 11.00 48 101465 32556 29440458
Oedema peripheral 23.28 11.00 235 101278 103322 29369692
Stress cardiomyopathy 22.77 11.00 28 101485 1596 29471418
Amphetamines positive 22.72 11.00 11 101502 146 29472868
Drug screen positive 22.54 11.00 44 101469 3757 29469257
Metastases to bone 22.50 11.00 80 101433 9818 29463196
Methaemoglobinaemia 22.41 11.00 36 101477 2635 29470379
Melaena 22.19 11.00 46 101467 31130 29441884
Atrial fibrillation 22.02 11.00 244 101269 105402 29367612
Electrocardiogram ST segment elevation 21.93 11.00 48 101465 4444 29468570
Ventricular fibrillation 21.92 11.00 110 101403 15723 29457291
Application site hypersensitivity 21.92 11.00 10 101503 115 29472899
Sciatic nerve neuropathy 21.88 11.00 8 101505 49 29472965
Anaemia 21.87 11.00 524 100989 200427 29272587
Systolic anterior motion of mitral valve 21.78 11.00 7 101506 27 29472987
Visual acuity reduced 21.69 11.00 12 101501 14864 29458150
Anaesthetic complication pulmonary 21.52 11.00 6 101507 12 29473002
White blood cell count decreased 21.39 11.00 183 101330 83179 29389835
Platelet count decreased 21.32 11.00 243 101270 104429 29368585
Type 2 diabetes mellitus 21.23 11.00 10 101503 13571 29459443
Influenza like illness 21.13 11.00 32 101481 24438 29448576
Paraplegia 21.05 11.00 34 101479 2500 29470514
Prostate cancer metastatic 20.86 11.00 50 101463 4916 29468098
Acidosis 20.84 11.00 77 101436 9628 29463386
Intercepted product dispensing error 20.74 11.00 8 101505 58 29472956
Bladder dilatation 20.72 11.00 24 101489 1284 29471730
Diabetes insipidus 20.69 11.00 33 101480 2401 29470613
Respiratory tract infection bacterial 20.62 11.00 17 101496 596 29472418
Acute respiratory distress syndrome 20.51 11.00 142 101371 22793 29450221
Pneumonitis chemical 20.31 11.00 10 101503 138 29472876
Hyperlipidaemia 20.10 11.00 9 101504 12581 29460433
Application site dermatitis 20.01 11.00 7 101506 37 29472977
Circulatory collapse 20.00 11.00 121 101392 18552 29454462
Glycosylated haemoglobin increased 20.00 11.00 4 101509 9422 29463592
Neutropenia 19.90 11.00 325 101188 131386 29341628
Dependence 19.87 11.00 21 101492 1014 29472000
Poor quality product administered 19.68 11.00 26 101487 1593 29471421
Hyperthermia 19.57 11.00 74 101439 9356 29463658
Presyncope 19.41 11.00 16 101497 16073 29456941
Hypotonic-hyporesponsive episode 19.34 11.00 6 101507 20 29472994
Erectile dysfunction 19.26 11.00 20 101493 17989 29455025
Leukoencephalopathy 19.25 11.00 41 101472 3726 29469288
Agranulocytosis 19.15 11.00 25 101488 20315 29452699
Drug-induced liver injury 19.00 11.00 28 101485 21627 29451387
Pancytopenia 18.99 11.00 188 101325 82980 29390034
Lethargy 18.99 11.00 205 101308 37375 29435639
Bronchitis 18.94 11.00 64 101449 36804 29436210
Pulse absent 18.87 11.00 49 101464 5064 29467950
Hypercapnic coma 18.83 11.00 10 101503 163 29472851
Mental status changes 18.81 11.00 193 101320 34734 29438280
Sinus arrest 18.78 11.00 24 101489 1423 29471591
Burkholderia test positive 18.70 11.00 20 101493 979 29472035
Hyperventilation 18.69 11.00 31 101482 2331 29470683
Postmortem blood drug level abnormal 18.68 11.00 12 101501 283 29472731
Ventricular tachycardia 18.58 11.00 137 101376 22437 29450577
Product contamination 18.43 11.00 16 101497 603 29472411
COVID-19 18.17 11.00 63 101450 35951 29437063
Acute myocardial infarction 18.12 11.00 95 101418 48343 29424671
Application site irritation 18.10 11.00 16 101497 618 29472396
Full blood count abnormal 18.03 11.00 15 101498 14998 29458016
Postoperative respiratory distress 17.93 11.00 5 101508 10 29473004
Blood catecholamines increased 17.93 11.00 5 101508 10 29473004
Musculoskeletal stiffness 17.92 11.00 67 101446 37391 29435623
Abdominal compartment syndrome 17.87 11.00 18 101495 821 29472193
Paraesthesia 17.77 11.00 110 101403 53735 29419279
Multiple organ dysfunction syndrome 17.77 11.00 310 101203 62806 29410208
Electrocardiogram ST segment depression 17.72 11.00 29 101484 2156 29470858
Sputum increased 17.60 11.00 27 101486 1900 29471114
Anal stenosis 17.55 11.00 9 101504 136 29472878
Pulmonary alveolar haemorrhage 17.55 11.00 55 101458 6325 29466689
Photosensitivity reaction 17.54 11.00 5 101508 9253 29463761
Posthaemorrhagic hydrocephalus 17.46 11.00 8 101505 93 29472921
Fluid retention 17.42 11.00 34 101479 23526 29449488
Haematuria 17.40 11.00 85 101428 44054 29428960
Skin exfoliation 17.34 11.00 32 101481 22613 29450401
Upper respiratory tract infection 17.31 11.00 43 101470 27306 29445708
Lower respiratory tract infection 17.31 11.00 41 101472 26461 29446553
Endotracheal intubation 17.19 11.00 32 101481 2637 29470377
Hypermagnesaemia 17.11 11.00 10 101503 198 29472816
Vomiting 17.02 11.00 891 100622 211369 29261645
Acute myeloid leukaemia 16.92 11.00 19 101494 16494 29456520
Sweat gland disorder 16.88 11.00 8 101505 101 29472913
Ventricular arrhythmia 16.86 11.00 44 101469 4560 29468454
Spinal cord infarction 16.85 11.00 11 101502 267 29472747
Cataract 16.80 11.00 32 101481 22346 29450668
Drug screen negative 16.77 11.00 9 101504 150 29472864
Device failure 16.68 11.00 27 101486 1989 29471025
Urinary retention 16.58 11.00 175 101338 31723 29441291
Injection site bruising 16.54 11.00 3 101510 7577 29465437
Pancreatic carcinoma 16.43 11.00 58 101455 7092 29465922
Substance abuse 16.42 11.00 56 101457 6731 29466283
Erythema 16.40 11.00 173 101340 75433 29397581
Eczema 16.37 11.00 14 101499 13812 29459202
Non-cardiogenic pulmonary oedema 16.28 11.00 15 101498 612 29472402
Blood pressure fluctuation 16.24 11.00 27 101486 19867 29453147
Spinal cord compression 16.06 11.00 37 101476 3545 29469469
Chest pain 16.03 11.00 279 101234 111694 29361320
Stoma closure 16.02 11.00 8 101505 114 29472900
Nasal congestion 16.00 11.00 25 101488 18854 29454160
Eye pain 15.99 11.00 10 101503 11585 29461429
Product tampering 15.98 11.00 6 101507 40 29472974
Progressive multifocal leukoencephalopathy 15.98 11.00 5 101508 8714 29464300
Drug tolerance increased 15.91 11.00 13 101500 450 29472564
Kounis syndrome 15.83 11.00 25 101488 1804 29471210
Asthenia 15.77 11.00 592 100921 214658 29258356
Lymphadenectomy 15.71 11.00 10 101503 232 29472782
Tendonitis 15.64 11.00 4 101509 7957 29465057
Product packaging quantity issue 15.54 11.00 16 101497 749 29472265
Weight bearing difficulty 15.54 11.00 17 101496 854 29472160
Tuberculosis 15.38 11.00 3 101510 7193 29465821
Therapeutic product effect incomplete 15.31 11.00 76 101437 39229 29433785
Intentional overdose 15.30 11.00 74 101439 38454 29434560
Air embolism 15.25 11.00 8 101505 127 29472887
Viral infection 15.22 11.00 17 101496 14793 29458221
Urinary bladder rupture 15.15 11.00 7 101506 83 29472931
Rash pruritic 15.08 11.00 34 101479 22329 29450685
Neonatal respiratory depression 15.08 11.00 12 101501 400 29472614
Local anaesthetic systemic toxicity 15.06 11.00 9 101504 186 29472828
Endotracheal intubation complication 15.05 11.00 11 101502 322 29472692
Injection site haemorrhage 15.04 11.00 5 101508 8381 29464633
Cancer pain 14.94 11.00 28 101485 2319 29470695
Vision blurred 14.91 11.00 79 101434 40097 29432917
Environmental exposure 14.82 11.00 10 101503 257 29472757
Squamous cell carcinoma of skin 14.80 11.00 7 101506 9479 29463535
Diabetes mellitus inadequate control 14.72 11.00 12 101501 12122 29460892
Contraindicated product administered 14.72 11.00 25 101488 18241 29454773
Myelodysplastic syndrome 14.67 11.00 24 101489 17770 29455244
Injection site swelling 14.62 11.00 7 101506 9410 29463604
Disease complication 14.61 11.00 28 101485 2358 29470656
Acute kidney injury 14.61 11.00 753 100760 264514 29208500
Application site erythema 14.57 11.00 26 101487 2073 29470941
Eastern Cooperative Oncology Group performance status worsened 14.35 11.00 15 101498 715 29472299
Meningococcal bacteraemia 14.35 11.00 4 101509 8 29473006
Electrocardiogram T wave alternans 14.35 11.00 4 101509 8 29473006
Substance dependence 14.23 11.00 11 101502 351 29472663
Motor neurone disease 14.20 11.00 11 101502 352 29472662
Secretion discharge 14.17 11.00 39 101474 4171 29468843
Cachexia 14.16 11.00 51 101462 6298 29466716
Atrial septal defect 14.16 11.00 3 101510 6786 29466228
Angina unstable 14.14 11.00 10 101503 10855 29462159
Preternatural anus 14.13 11.00 7 101506 98 29472916
Large intestine anastomosis 14.06 11.00 6 101507 58 29472956
Anaesthetic complication cardiac 14.05 11.00 5 101508 28 29472986
Performance status decreased 14.04 11.00 36 101477 3691 29469323
Hippocampal atrophy 14.03 11.00 3 101510 0 29473014
Product packaging issue 14.03 11.00 13 101500 534 29472480
Urinary ascites 14.03 11.00 4 101509 9 29473005
Foetal megacystis 14.03 11.00 4 101509 9 29473005
Gastrooesophageal reflux disease 14.01 11.00 58 101455 31438 29441576
Contusion 13.99 11.00 57 101456 31038 29441976
Laryngeal cancer metastatic 13.97 11.00 6 101507 59 29472955
Hepatic enzyme increased 13.96 11.00 64 101449 33735 29439279
Haematotoxicity 13.89 11.00 3 101510 6696 29466318
Exposure during pregnancy 13.84 11.00 6 101507 8548 29464466
Swollen tongue 13.83 11.00 13 101500 12253 29460761
Leukopenia 13.79 11.00 122 101391 55081 29417933
Hyponatraemia 13.77 11.00 157 101356 67476 29405538
Oesophageal mucosa erythema 13.76 11.00 5 101508 30 29472984
Mechanical ventilation complication 13.74 11.00 4 101509 10 29473004
PCO2 increased 13.73 11.00 13 101500 549 29472465
Oedema 13.72 11.00 82 101431 40401 29432613
Vasoplegia syndrome 13.59 11.00 21 101492 1487 29471527
Neuroendocrine tumour of the lung metastatic 13.52 11.00 7 101506 108 29472906
Aspergillus infection 13.43 11.00 10 101503 10571 29462443
Therapy interrupted 13.38 11.00 6 101507 8380 29464634
Social anxiety disorder 13.38 11.00 9 101504 230 29472784
Capillary nail refill test abnormal 13.36 11.00 5 101508 33 29472981
Chronic obstructive pulmonary disease 13.34 11.00 84 101429 40871 29432143
Therapeutic product effect prolonged 13.31 11.00 9 101504 232 29472782
Rash maculo-papular 13.28 11.00 41 101472 24248 29448766
Pulmonary haemorrhage 13.26 11.00 65 101448 9205 29463809
Orthostatic hypotension 13.24 11.00 37 101476 22592 29450422
Catecholamine crisis 13.24 11.00 5 101508 34 29472980
Hypophonesis 13.21 11.00 4 101509 12 29473002
Cardiac failure chronic 13.20 11.00 3 101510 6464 29466550
Unwanted awareness during anaesthesia 13.11 11.00 5 101508 35 29472979
Multiple sclerosis relapse 13.00 11.00 12 101501 11407 29461607
Locked-in syndrome 12.98 11.00 9 101504 242 29472772
Lower respiratory tract infection bacterial 12.94 11.00 10 101503 319 29472695
Gynaecomastia 12.92 11.00 6 101507 8211 29464803
Psoriatic arthropathy 12.89 11.00 19 101494 14672 29458342
Paralysis recurrent laryngeal nerve 12.88 11.00 5 101508 37 29472977
Arthropathy 12.79 11.00 35 101478 21519 29451495
Gastrointestinal disorder 12.68 11.00 53 101460 28653 29444361
Medical device site fistula 12.65 11.00 5 101508 39 29472975
Mucosal atrophy 12.64 11.00 6 101507 76 29472938
Ear infection 12.61 11.00 6 101507 8094 29464920
Myelosuppression 12.60 11.00 14 101499 12213 29460801
Product communication issue 12.52 11.00 7 101506 127 29472887
Non-small cell lung cancer 12.50 11.00 30 101483 2951 29470063
Haematochezia 12.49 11.00 75 101438 36908 29436106
Dental caries 12.40 11.00 37 101476 4143 29468871
Toxicologic test abnormal 12.40 11.00 12 101501 521 29472493
Dyskinesia 12.34 11.00 114 101399 19947 29453067
Trismus 12.32 11.00 26 101487 2347 29470667
Injection site erythema 12.29 11.00 18 101495 13938 29459076
Pathological fracture 12.28 11.00 35 101478 3820 29469194
Application site vesicles 12.23 11.00 12 101501 530 29472484
Chronic kidney disease 12.22 11.00 74 101439 36342 29436672
Metabolic disorder 12.21 11.00 34 101479 3661 29469353
Hypogonadism 12.18 11.00 20 101493 1491 29471523
Mean arterial pressure decreased 12.09 11.00 7 101506 136 29472878
Sleep disorder 12.07 11.00 43 101470 24343 29448671
Tracheal pain 12.03 11.00 5 101508 45 29472969
Dyslipidaemia 12.00 11.00 3 101510 6058 29466956
Localised infection 11.99 11.00 18 101495 13798 29459216
Wheezing 11.98 11.00 66 101447 33174 29439840
Mitochondrial encephalomyopathy 11.97 11.00 3 101510 3 29473011
Glossopharyngeal nerve paralysis 11.97 11.00 3 101510 3 29473011
Atonic urinary bladder 11.96 11.00 4 101509 18 29472996
Vein collapse 11.94 11.00 5 101508 46 29472968
Mucous stools 11.92 11.00 17 101496 1120 29471894
Application site pain 11.92 11.00 21 101492 1658 29471356
Anion gap abnormal 11.91 11.00 7 101506 140 29472874
Postmortem blood drug level 11.91 11.00 7 101506 140 29472874
Pseudopolyp 11.87 11.00 8 101505 205 29472809
Motor dysfunction 11.86 11.00 46 101467 5884 29467130
Areflexia 11.86 11.00 28 101485 2726 29470288
Completed suicide 11.81 11.00 399 101114 89847 29383167
Bronchopulmonary aspergillosis 11.80 11.00 15 101498 12329 29460685
Diaphragmatic rupture 11.78 11.00 4 101509 19 29472995
Oropharyngeal pain 11.77 11.00 56 101457 29229 29443785
Pupil fixed 11.77 11.00 21 101492 1675 29471339
Disease recurrence 11.73 11.00 23 101490 15891 29457123
Thrombosis 11.71 11.00 93 101420 42952 29430062
Condition aggravated 11.69 11.00 398 101115 145897 29327117
Stress 11.69 11.00 119 101394 21371 29451643
Drug ineffective 11.65 11.00 1081 100432 362089 29110925
Cytopenia 11.65 11.00 10 101503 9849 29463165
Drug intolerance 11.61 11.00 108 101405 48271 29424743
Dry skin 11.60 11.00 41 101472 23266 29449748
Complication of device removal 11.57 11.00 5 101508 50 29472964
Clinical trial participant 11.57 11.00 6 101507 93 29472921
Claustrophobia 11.54 11.00 8 101505 215 29472799
Spinal column injury 11.51 11.00 11 101502 470 29472544
Rash erythematous 11.37 11.00 37 101476 21525 29451489
Gastritis 11.36 11.00 32 101481 19485 29453529
Productive cough 11.30 11.00 62 101451 31197 29441817
Malignant catatonia 11.29 11.00 8 101505 223 29472791
Pain in jaw 11.28 11.00 14 101499 11627 29461387
Asphyxia 11.27 11.00 42 101471 5273 29467741
Pneumonia aspiration 11.27 11.00 183 101330 36554 29436460
Knee arthroplasty 11.26 11.00 3 101510 5806 29467208
Visual impairment 11.25 11.00 58 101455 29650 29443364
Torsade de pointes 11.22 11.00 49 101464 6612 29466402
Lymphadenopathy 11.22 11.00 46 101467 25003 29448011
Jaundice 11.21 11.00 57 101456 29239 29443775
Laryngomalacia 11.20 11.00 9 101504 304 29472710
Pathogen resistance 11.19 11.00 7 101506 8109 29464905
Airway peak pressure increased 11.15 11.00 4 101509 23 29472991
Mobility decreased 11.14 11.00 48 101465 25732 29447282
Muscle spasms 11.04 11.00 157 101356 64925 29408089

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 9602.52 9.97 5554 186533 126820 64179825
Toxicity to various agents 2443.35 9.97 4083 188004 359430 63947215
Respiratory arrest 1227.31 9.97 1116 190971 51869 64254776
Cardio-respiratory arrest 1074.80 9.97 1393 190694 97000 64209645
Cardiac arrest 1072.10 9.97 1762 190325 152302 64154343
Serotonin syndrome 1000.09 9.97 873 191214 38409 64268236
Incorrect route of product administration 896.99 9.97 660 191427 22638 64284007
Respiratory depression 837.57 9.97 635 191452 22808 64283837
Overdose 705.61 9.97 1503 190584 158063 64148582
Intentional product misuse 544.61 9.97 858 191229 71437 64235208
Drug withdrawal syndrome 523.70 9.97 552 191535 30739 64275906
Anaphylactic reaction 477.67 9.97 786 191301 67878 64238767
Death 462.84 9.97 2730 189357 479975 63826670
Inadequate analgesia 405.71 9.97 210 191877 3768 64302877
Product adhesion issue 403.74 9.97 180 191907 2279 64304366
Unresponsive to stimuli 397.44 9.97 611 191476 49782 64256863
Miosis 378.67 9.97 315 191772 12951 64293694
Drug dependence 348.27 9.97 462 191625 32850 64273795
Accidental exposure to product by child 345.40 9.97 162 191925 2323 64304322
Hyperthermia malignant 337.76 9.97 159 191928 2300 64304345
Apnoea 315.32 9.97 256 191831 10166 64296479
Drug interaction 297.57 9.97 1970 190117 360113 63946532
Depressed level of consciousness 287.17 9.97 702 191385 80734 64225911
Delayed recovery from anaesthesia 273.98 9.97 119 191968 1409 64305236
Somnolence 264.50 9.97 1254 190833 202391 64104254
Anaesthetic complication 259.71 9.97 135 191952 2444 64304201
Synovitis 258.46 9.97 8 192079 99082 64207563
Delirium 255.24 9.97 607 191480 68587 64238058
Hyperaesthesia 251.55 9.97 221 191866 9793 64296852
Accidental overdose 243.91 9.97 392 191695 33165 64273480
Hypotension 234.78 9.97 1936 190151 379038 63927607
Pulmonary oedema 228.84 9.97 631 191456 78043 64228602
Headache 226.80 9.97 813 191274 528654 63777991
Arthralgia 226.72 9.97 626 191461 441634 63865011
Joint swelling 207.70 9.97 201 191886 215181 64091464
Nasopharyngitis 203.37 9.97 171 191916 195902 64110743
Product prescribing error 202.38 9.97 371 191716 34898 64271747
Infusion related reaction 197.19 9.97 123 191964 164344 64142301
Cough 193.84 9.97 379 191708 301769 64004876
Product quality issue 190.98 9.97 329 191758 29470 64277175
Bradycardia 189.03 9.97 775 191312 117444 64189201
Alopecia 187.73 9.97 132 191955 165558 64141087
Rash 179.47 9.97 730 191357 457819 63848826
Neuromuscular block prolonged 178.16 9.97 77 192010 900 64305745
Systemic lupus erythematosus 175.24 9.97 15 192072 77597 64229048
Sinusitis 173.74 9.97 110 191977 145818 64160827
Product complaint 172.29 9.97 195 191892 11759 64294886
Respiratory acidosis 170.45 9.97 177 191910 9678 64296967
Myoclonus 169.80 9.97 284 191803 24834 64281811
Hand deformity 167.65 9.97 4 192083 62767 64243878
Bradypnoea 165.15 9.97 131 191956 5028 64301617
Fatigue 163.11 9.97 1437 190650 747293 63559352
Maternal exposure during delivery 161.82 9.97 70 192017 820 64305825
Rheumatoid arthritis 161.06 9.97 151 191936 164143 64142502
Malignant neoplasm progression 158.89 9.97 712 191375 112159 64194486
Arthropathy 158.58 9.97 81 192006 120886 64185759
Withdrawal syndrome 151.36 9.97 260 191827 23232 64283413
Fear 145.70 9.97 235 191852 19936 64286709
Glossodynia 142.05 9.97 14 192073 64682 64241963
Respiratory rate decreased 139.41 9.97 112 191975 4379 64302266
Peripheral swelling 137.83 9.97 258 191829 208895 64097750
Pulseless electrical activity 136.69 9.97 179 191908 12560 64294085
Procedural hypotension 135.48 9.97 79 192008 1807 64304838
Anaphylactic shock 135.23 9.97 287 191800 30041 64276604
Abdominal discomfort 133.78 9.97 210 191877 182112 64124533
Pruritus 131.92 9.97 482 191605 311918 63994727
Weight increased 131.26 9.97 274 191813 213074 64093571
Post procedural complication 129.35 9.97 230 191857 21123 64285522
Hypoxia 128.53 9.97 562 191525 87587 64219058
Injection site pain 128.49 9.97 87 192000 111321 64195324
Product dose omission issue 126.76 9.97 242 191845 194505 64112140
Contraindicated product administered 121.97 9.97 86 192001 107743 64198902
Drug use disorder 119.86 9.97 117 191970 5937 64300708
Renal injury 118.67 9.97 185 191902 15244 64291401
Brain oedema 117.64 9.97 225 191862 21850 64284795
Coma 117.55 9.97 545 191542 87070 64219575
Pericarditis 117.27 9.97 22 192065 62494 64244151
Drug intolerance 114.31 9.97 243 191844 187749 64118896
Agitation 111.51 9.97 540 191547 87827 64218818
Drug abuser 108.97 9.97 109 191978 5699 64300946
Neoplasm progression 108.76 9.97 318 191769 40646 64265999
Hypoventilation 107.72 9.97 110 191977 5896 64300749
Swelling 105.20 9.97 198 191889 160020 64146625
Diarrhoea 105.01 9.97 1519 190568 721185 63585460
Anhedonia 104.94 9.97 164 191923 13542 64293103
Muscle rigidity 104.29 9.97 187 191900 17286 64289359
Myalgia 104.17 9.97 196 191891 158421 64148224
Hepatic enzyme increased 102.78 9.97 142 191945 129801 64176844
Poisoning 102.15 9.97 211 191876 21668 64284977
Oxygen saturation decreased 101.27 9.97 605 191482 106571 64200074
Blood pressure decreased 101.13 9.97 516 191571 85683 64220962
Bronchospasm 101.11 9.97 209 191878 21473 64285172
Tachycardia 99.34 9.97 774 191313 148805 64157840
Treatment failure 97.14 9.97 123 191964 116693 64189952
Helicobacter infection 96.87 9.97 4 192083 38358 64268287
Opiates positive 96.18 9.97 49 192038 849 64305796
Procedural complication 95.45 9.97 113 191974 7152 64299493
Product counterfeit 95.28 9.97 33 192054 199 64306446
Lower respiratory tract infection 95.01 9.97 85 192002 94529 64212116
Respiratory failure 94.62 9.97 811 191276 160372 64146273
Off label use 91.15 9.97 1332 190755 631474 63675171
Presbyacusis 90.27 9.97 69 192018 2506 64304139
Stress cardiomyopathy 90.04 9.97 124 191963 9133 64297512
Medication error 89.84 9.97 340 191747 49626 64257019
Drug diversion 88.05 9.97 50 192037 1086 64305559
Circulatory collapse 87.77 9.97 260 191827 33472 64273173
Emotional distress 86.48 9.97 270 191817 35768 64270877
Laryngospasm 86.46 9.97 76 192011 3369 64303276
Plasma cell myeloma 83.24 9.97 314 191773 45761 64260884
Haemodynamic instability 83.19 9.97 155 191932 14757 64291888
Pain in extremity 79.50 9.97 552 191535 302533 64004112
Toxic leukoencephalopathy 78.36 9.97 43 192044 872 64305773
Ventricular tachycardia 77.91 9.97 252 191835 34013 64272632
Asthma 77.38 9.97 102 191985 95123 64211522
Duodenal ulcer perforation 77.31 9.97 7 192080 34618 64272027
Deafness neurosensory 76.98 9.97 95 191992 6279 64300366
Confusional state 75.56 9.97 1144 190943 260000 64046645
Influenza 75.01 9.97 126 191961 106405 64200240
Propofol infusion syndrome 74.18 9.97 51 192036 1566 64305079
Sedation 73.60 9.97 281 191806 41181 64265464
Therapeutic product effect incomplete 73.22 9.97 122 191965 103360 64203285
Prescription drug used without a prescription 72.66 9.97 61 192026 2539 64304106
Hypercapnia 71.75 9.97 101 191986 7593 64299052
Cardiac failure congestive 71.12 9.97 179 191908 130401 64176244
Cyanosis 70.72 9.97 184 191903 21971 64284674
Injection site erythema 70.60 9.97 64 192023 70736 64235909
Pleural fibrosis 70.50 9.97 73 192014 3977 64302668
Dizziness 70.28 9.97 882 191205 429281 63877364
Amnestic disorder 70.23 9.97 34 192053 525 64306120
Completed suicide 69.98 9.97 996 191091 223418 64083227
Constipation 68.80 9.97 1011 191076 228326 64078319
Anaesthetic complication neurological 68.03 9.97 33 192054 512 64306133
Brain injury 67.78 9.97 113 191974 9852 64296793
Folliculitis 67.37 9.97 6 192081 30071 64276574
Dyspnoea exertional 67.35 9.97 72 192015 73658 64232987
Hypoxic-ischaemic encephalopathy 66.87 9.97 94 191993 7058 64299587
Urinary retention 66.66 9.97 307 191780 48894 64257751
Hypersensitivity 66.27 9.97 330 191757 196122 64110523
Therapy naive 66.23 9.97 17 192070 26 64306619
Blood magnesium increased 65.01 9.97 63 192024 3168 64303477
Labile blood pressure 64.83 9.97 52 192035 2028 64304617
Injury 64.83 9.97 334 191753 55658 64250987
Counterfeit product administered 64.39 9.97 21 192066 102 64306543
Irritable bowel syndrome 64.28 9.97 16 192071 37353 64269292
Wrong technique in product usage process 64.07 9.97 371 191716 64603 64242042
Airway complication of anaesthesia 63.95 9.97 29 192058 383 64306262
Narcotic bowel syndrome 63.21 9.97 25 192062 229 64306416
Faecaloma 63.10 9.97 108 191979 9620 64297025
Pleural thickening 62.50 9.97 57 192030 2653 64303992
Intensive care unit acquired weakness 62.13 9.97 47 192040 1680 64304965
Intercepted product dispensing error 61.87 9.97 21 192066 118 64306527
Clonus 61.63 9.97 83 192004 5984 64300661
Drug ineffective 58.78 9.97 1983 190104 838264 63468381
Tryptase increased 57.74 9.97 28 192059 434 64306211
Drug screen positive 57.62 9.97 78 192009 5651 64300994
Accidental death 57.52 9.97 63 192024 3662 64302983
Kounis syndrome 57.17 9.97 57 192030 2968 64303677
Multiple organ dysfunction syndrome 56.73 9.97 505 191582 100908 64205737
Malaise 56.56 9.97 835 191252 395412 63911233
Disorientation 55.84 9.97 320 191767 55508 64251137
Dyspnoea 55.52 9.97 1674 190413 717000 63589645
Infusion site coldness 55.29 9.97 22 192065 205 64306440
Herpes zoster 54.51 9.97 95 191992 79092 64227553
Red blood cell sedimentation rate increased 54.46 9.97 13 192074 31222 64275423
Chest discomfort 54.45 9.97 171 191916 115935 64190710
Therapeutic product effect prolonged 54.25 9.97 28 192059 499 64306146
Ill-defined disorder 54.07 9.97 32 192055 44020 64262625
Tachypnoea 53.84 9.97 188 191899 26383 64280262
Mental status changes 53.79 9.97 339 191748 60823 64245822
Pulse absent 53.71 9.97 96 191991 8850 64297795
Application site pruritus 53.17 9.97 59 192028 3480 64303165
Coma scale abnormal 52.67 9.97 88 191999 7686 64298959
Palpitations 51.79 9.97 150 191937 104338 64202307
Injection site reaction 51.73 9.97 38 192049 46626 64260019
Therapeutic product effect increased 51.63 9.97 38 192049 1302 64305343
Basal cell carcinoma 51.52 9.97 14 192073 30824 64275821
Wound 51.51 9.97 93 191994 76384 64230261
Abortion spontaneous 51.30 9.97 7 192080 25136 64281509
Arthritis 51.18 9.97 108 191979 83706 64222939
Ventricular fibrillation 51.13 9.97 172 191915 23688 64282957
Bronchitis 51.11 9.97 160 191927 108583 64198062
Device expulsion 50.83 9.97 3 192084 21133 64285512
Recurrence of neuromuscular blockade 50.49 9.97 20 192067 184 64306461
Application site erythema 50.48 9.97 66 192021 4623 64302022
Nasal congestion 50.43 9.97 62 192025 59596 64247049
Oropharyngeal pain 49.80 9.97 120 191967 88747 64217898
Drug tolerance 49.66 9.97 75 192012 6010 64300635
Knee arthroplasty 49.58 9.97 10 192077 26989 64279656
Cerebrovascular accident 49.36 9.97 226 191861 137357 64169288
Metastases to bone 48.93 9.97 153 191934 20282 64286363
C-reactive protein abnormal 48.88 9.97 13 192074 29034 64277611
Injection site pruritus 47.10 9.97 27 192060 37799 64268846
Musculoskeletal stiffness 46.86 9.97 198 191889 123008 64183637
Blood cholesterol increased 46.73 9.97 48 192039 50018 64256627
Anion gap 46.48 9.97 41 192046 1826 64304819
Transient ischaemic attack 46.41 9.97 38 192049 44144 64262501
Condition aggravated 46.38 9.97 805 191282 371621 63935024
Allodynia 46.34 9.97 35 192052 1248 64305397
Application site reaction 46.27 9.97 28 192059 687 64305958
Endotracheal intubation complication 46.23 9.97 28 192059 688 64305957
Gastrooesophageal reflux disease 46.01 9.97 113 191974 83030 64223615
Myoglobin urine present 45.81 9.97 26 192061 564 64306081
Unevaluable event 45.74 9.97 282 191805 50207 64256438
Loss of consciousness 45.61 9.97 657 191430 147708 64158937
Gamma-glutamyltransferase decreased 45.54 9.97 22 192065 338 64306307
Local anaesthetic systemic toxicity 44.78 9.97 27 192060 658 64305987
Upper airway obstruction 44.74 9.97 34 192053 1224 64305421
Epigastric discomfort 44.68 9.97 76 192011 6735 64299910
General physical health deterioration 44.66 9.97 856 191231 203569 64103076
Accidental exposure to product 43.80 9.97 175 191912 26189 64280456
Anterior spinal artery syndrome 43.65 9.97 15 192072 88 64306557
Hyperhidrosis 43.63 9.97 566 191521 124354 64182291
Neuromuscular blockade 43.59 9.97 24 192063 490 64306155
Spinal muscular atrophy 43.45 9.97 20 192067 274 64306371
Hip arthroplasty 43.43 9.97 6 192081 21345 64285300
Psoriasis 43.28 9.97 93 191994 71610 64235035
Application site rash 42.93 9.97 40 192047 1914 64304731
Injection site swelling 42.90 9.97 36 192051 41317 64265328
Breakthrough pain 41.25 9.97 32 192055 1188 64305457
Blood potassium increased 41.21 9.97 170 191917 25810 64280835
Diabetes mellitus 41.14 9.97 85 192002 66389 64240256
Anaesthetic complication pulmonary 40.94 9.97 13 192074 57 64306588
Amphetamines positive 40.72 9.97 18 192069 223 64306422
Hypermobility syndrome 40.61 9.97 23 192064 497 64306148
Diabetic ketoacidosis 40.58 9.97 19 192068 29826 64276819
Compartment syndrome 40.13 9.97 56 192031 4176 64302469
Abdominal pain upper 40.04 9.97 331 191756 174699 64131946
Type 2 diabetes mellitus 39.97 9.97 26 192061 33994 64272651
Electrocardiogram ST segment elevation 39.92 9.97 75 192012 7184 64299461
Loss of personal independence in daily activities 39.68 9.97 99 191988 72355 64234290
Renal failure 39.41 9.97 760 191327 180928 64125717
Pulmonary congestion 39.26 9.97 158 191929 23722 64282923
Cytomegalovirus infection 39.06 9.97 32 192055 37167 64269478
Methaemoglobinaemia 38.96 9.97 56 192031 4292 64302353
Discomfort 38.71 9.97 118 191969 80760 64225885
Negative pressure pulmonary oedema 38.50 9.97 17 192070 210 64306435
Mobility decreased 38.45 9.97 129 191958 85711 64220934
Acute lung injury 38.42 9.97 44 192043 2687 64303958
Brain death 38.38 9.97 59 192028 4802 64301843
Metabolic acidosis 37.96 9.97 350 191737 70608 64236037
Airway peak pressure increased 37.88 9.97 19 192068 318 64306327
Encephalopathy 37.70 9.97 302 191785 58517 64248128
Hypopnoea 37.60 9.97 47 192040 3147 64303498
Increased bronchial secretion 37.00 9.97 44 192043 2798 64303847
Gait disturbance 36.95 9.97 331 191756 171824 64134821
Acute respiratory distress syndrome 36.88 9.97 220 191867 38715 64267930
Ear infection 36.60 9.97 12 192075 23392 64283253
Blood glucose increased 36.43 9.97 159 191928 97914 64208731
Epistaxis 35.91 9.97 160 191927 97971 64208674
Sinus tachycardia 35.87 9.97 190 191897 31998 64274647
Lethargy 35.83 9.97 352 191735 72242 64234403
Vomiting 35.77 9.97 1994 190093 549123 63757522
Resuscitation 35.76 9.97 37 192050 2014 64304631
Upper respiratory tract infection 35.69 9.97 105 191982 72680 64233965
Exposure to toxic agent 35.58 9.97 65 192022 6094 64300551
Bone cyst 35.40 9.97 38 192049 2159 64304486
Bradycardia foetal 35.30 9.97 13 192074 96 64306549
Horner's syndrome 35.19 9.97 10 192077 27 64306618
Application site dermatitis 35.11 9.97 15 192072 170 64306475
Progressive multifocal leukoencephalopathy 35.09 9.97 6 192081 18226 64288419
Unwanted awareness during anaesthesia 34.80 9.97 17 192070 268 64306377
Stomatitis 34.74 9.97 188 191899 109417 64197228
Blister 34.70 9.97 124 191963 80843 64225802
Procedural hypertension 34.47 9.97 17 192070 274 64306371
Rhinorrhoea 34.37 9.97 80 192007 59889 64246756
Osteopenia 34.16 9.97 113 191974 15427 64291218
Anterograde amnesia 33.72 9.97 22 192065 618 64306027
Oxygen saturation immeasurable 33.71 9.97 10 192077 33 64306612
Intentional product use issue 33.68 9.97 433 191654 94931 64211714
Product use issue 33.31 9.97 290 191797 151425 64155220
Nephrolithiasis 33.27 9.97 49 192038 43634 64263011
Arteriospasm coronary 33.27 9.97 59 192028 5406 64301239
Cataract 33.05 9.97 64 192023 51198 64255447
Fluid retention 32.99 9.97 81 192006 59525 64247120
Productive cough 32.79 9.97 110 191977 73093 64233552
Postoperative delirium 32.59 9.97 14 192073 161 64306484
Carcinoid crisis 32.57 9.97 19 192068 435 64306210
Post procedural hypotension 32.53 9.97 11 192076 61 64306584
Myocardial infarction 32.52 9.97 326 191761 165495 64141150
Orthostatic hypotension 32.22 9.97 56 192031 46682 64259963
Contusion 32.11 9.97 203 191884 113762 64192883
Paraplegia 32.00 9.97 52 192035 4438 64302207
COVID-19 31.92 9.97 94 191993 65046 64241599
Osteoporosis 31.27 9.97 48 192039 42032 64264613
Trigemino-cardiac reflex 31.14 9.97 15 192072 229 64306416
Cauda equina syndrome 31.07 9.97 26 192061 1077 64305568
Restlessness 31.02 9.97 214 191873 39571 64267074
Rash pruritic 30.99 9.97 79 192008 57325 64249320
Systolic anterior motion of mitral valve 30.93 9.97 10 192077 47 64306598
Cachexia 30.92 9.97 78 192009 9139 64297506
Femoral hernia incarcerated 30.27 9.97 22 192065 739 64305906
Postmortem blood drug level increased 30.27 9.97 22 192065 739 64305906
Vasodilatation 30.22 9.97 41 192046 2977 64303668
Drug resistance 30.17 9.97 36 192051 35066 64271579
Left ventricle outflow tract obstruction 30.13 9.97 16 192071 303 64306342
Osteosclerosis 29.93 9.97 44 192043 3442 64303203
Cancer pain 29.93 9.97 49 192038 4208 64302437
Multiple sclerosis relapse 29.55 9.97 48 192039 41087 64265558
Blood pressure measurement 29.54 9.97 17 192070 379 64306266
Self-medication 29.53 9.97 48 192039 4097 64302548
Blood pressure increased 29.53 9.97 350 191737 172202 64134443
Injection site bruising 29.50 9.97 39 192048 36334 64270311
Visual impairment 29.44 9.97 117 191970 73960 64232685
Insomnia 29.18 9.97 414 191673 197422 64109223
Altered state of consciousness 29.04 9.97 203 191884 37699 64268946
Arachnoid web 28.91 9.97 7 192080 7 64306638
Psoriatic arthropathy 28.81 9.97 53 192034 43228 64263417
Hepatic ischaemia 28.61 9.97 24 192063 998 64305647
Generalised tonic-clonic seizure 28.53 9.97 210 191877 39647 64266998
Application site irritation 28.51 9.97 29 192058 1547 64305098
Infusion site induration 28.50 9.97 22 192065 811 64305834
Spinal cord infarction 28.47 9.97 19 192068 555 64306090
Angina pectoris 28.44 9.97 57 192030 45024 64261621
Oedema peripheral 28.30 9.97 448 191639 209869 64096776
Fibromyalgia 28.28 9.97 39 192048 35692 64270953
Anaesthetic complication cardiac 28.24 9.97 10 192077 65 64306580
Poor quality product administered 28.21 9.97 41 192046 3174 64303471
Lymphatic fistula 28.09 9.97 21 192066 737 64305908
Pupil fixed 28.04 9.97 41 192046 3191 64303454
Drug-induced liver injury 27.75 9.97 63 192024 47580 64259065
Erythema 27.75 9.97 391 191696 186679 64119966
Fall 27.53 9.97 990 191097 415836 63890809
Prostate cancer metastatic 27.36 9.97 41 192046 3263 64303382
Non-cardiogenic pulmonary oedema 27.25 9.97 26 192061 1282 64305363
Viral infection 27.07 9.97 41 192046 36099 64270546
Application site vesicles 27.02 9.97 26 192061 1296 64305349
Postmortem blood drug level 27.00 9.97 14 192073 252 64306393
Infection 26.87 9.97 388 191699 184492 64122153
Mental status changes postoperative 26.77 9.97 12 192075 154 64306491
Hallucination 26.76 9.97 333 191754 72455 64234190
Gastrointestinal disorder 26.73 9.97 157 191930 89552 64217093
Hyperreflexia 26.65 9.97 63 192024 7085 64299560
Non-consummation 26.60 9.97 9 192078 50 64306595
Anorectal ulcer 26.60 9.97 9 192078 50 64306595
Sinus arrest 26.52 9.97 39 192048 3051 64303594
Substance abuse 26.47 9.97 74 192013 9218 64297427
Product administered at inappropriate site 26.33 9.97 39 192048 3071 64303574
Anticholinergic syndrome 26.33 9.97 36 192051 2633 64304012
Acidosis 26.33 9.97 114 191973 17681 64288964
Muscle relaxant therapy 26.10 9.97 12 192075 164 64306481
Mean arterial pressure decreased 26.08 9.97 15 192072 334 64306311
Dependence 25.83 9.97 32 192055 2123 64304522
Pregnancy 25.83 9.97 15 192072 20850 64285795
Dyskinesia 25.66 9.97 203 191884 39185 64267460
Throat irritation 25.59 9.97 36 192051 32675 64273970
Eye pain 25.55 9.97 34 192053 31591 64275054
Seroma 25.43 9.97 31 192056 2023 64304622
Thermophobia 25.35 9.97 9 192078 59 64306586
Sneezing 25.33 9.97 7 192080 15244 64291401
Joint stiffness 25.27 9.97 32 192055 30372 64276273
Pneumonia aspiration 25.27 9.97 279 191808 58992 64247653
C-reactive protein increased 25.25 9.97 172 191915 94737 64211908
Diabetes insipidus 25.22 9.97 47 192040 4474 64302171
Wheezing 25.10 9.97 139 191948 80440 64226205
Oculocardiac reflex 24.97 9.97 9 192078 62 64306583
Eye swelling 24.88 9.97 18 192069 22263 64284382
Pancreatic steatosis 24.82 9.97 22 192065 986 64305659
Acute motor axonal neuropathy 24.78 9.97 10 192077 97 64306548
Conversion disorder 24.70 9.97 28 192059 1691 64304954
Exposure during pregnancy 24.66 9.97 346 191741 77329 64229316
Swelling face 24.44 9.97 92 191995 59074 64247571
Autonomic nervous system imbalance 24.37 9.97 44 192043 4088 64302557
Neuropathy peripheral 24.32 9.97 228 191859 117297 64189348
Confusion postoperative 24.30 9.97 12 192075 194 64306451
Atrioventricular block second degree 24.19 9.97 57 192030 6397 64300248
Performance status decreased 24.18 9.97 51 192036 5313 64301332
Eosinophilia 24.14 9.97 48 192039 38028 64268617
Eczema 23.96 9.97 32 192055 29688 64276957
Pyrexia 23.88 9.97 1391 190696 557253 63749392
Apnoeic attack 23.84 9.97 17 192070 554 64306091
Haemoglobin decreased 23.79 9.97 423 191664 194640 64112005
Localised infection 23.79 9.97 33 192054 30128 64276517
Air embolism 23.78 9.97 15 192072 397 64306248
Acute postoperative sialadenitis 23.71 9.97 8 192079 44 64306601
Product contamination 23.71 9.97 22 192065 1047 64305598
Normal newborn 23.71 9.97 52 192035 5565 64301080
Coronary artery disease 23.66 9.97 96 191991 60337 64246308
Product packaging quantity issue 23.62 9.97 21 192066 945 64305700
Cystitis 23.61 9.97 58 192029 42617 64264028
Tuberculosis 23.58 9.97 5 192082 13033 64293612
Opisthotonus 23.56 9.97 18 192069 653 64305992
Neurotoxicity 23.53 9.97 151 191936 27253 64279392
Vascular resistance systemic decreased 23.45 9.97 12 192075 210 64306435
Musculoskeletal disorder 23.43 9.97 12 192075 17894 64288751
Postoperative ileus 23.34 9.97 21 192066 960 64305685
Tachyphylaxis 23.24 9.97 13 192074 274 64306371
Deformity 22.93 9.97 55 192032 6242 64300403
Balance disorder 22.87 9.97 151 191936 83775 64222870
Febrile neutropenia 22.87 9.97 407 191680 187250 64119395
Dystonia 22.86 9.97 114 191973 18751 64287894
Blood pressure diastolic abnormal 22.76 9.97 4 192083 11913 64294732
Coma blister 22.75 9.97 12 192075 224 64306421
Drug tolerance increased 22.56 9.97 17 192070 604 64306041
Depressed mood 22.48 9.97 56 192031 40956 64265689
Leukoencephalopathy 22.37 9.97 58 192029 6909 64299736
Application site pain 22.26 9.97 43 192044 4205 64302440
Wound infection pseudomonas 22.08 9.97 25 192062 1508 64305137
Tumour pain 22.05 9.97 28 192059 1905 64304740
Potentiating drug interaction 21.84 9.97 62 192025 7790 64298855
Skin exfoliation 21.82 9.97 65 192022 44820 64261825
Torsade de pointes 21.80 9.97 106 191981 17257 64289388
Pseudopolyp 21.59 9.97 14 192073 389 64306256
Wrong product administered 21.52 9.97 61 192026 7659 64298986
Supraventricular tachycardia 21.33 9.97 112 191975 18795 64287850
Anaphylactoid reaction 21.30 9.97 45 192042 4693 64301952
Spinal anaesthesia 21.28 9.97 8 192079 63 64306582
Photosensitivity reaction 21.20 9.97 14 192073 18159 64288486
Limb discomfort 21.17 9.97 30 192057 27145 64279500
Syncope 21.12 9.97 336 191751 157299 64149346
Granulocytopenia 21.08 9.97 3 192084 10437 64296208
Hyperthermia 21.03 9.97 97 191990 15453 64291192
Vision blurred 21.00 9.97 170 191917 90146 64216499
Spinal cord compression 20.97 9.97 50 192037 5653 64300992
Myelosuppression 20.95 9.97 24 192063 23806 64282839
Transplant rejection 20.85 9.97 13 192074 17388 64289257
Injection site haemorrhage 20.76 9.97 25 192062 24253 64282392
Liver disorder 20.73 9.97 85 192002 53266 64253379
Systemic infection 20.55 9.97 42 192045 4279 64302366
Pathogen resistance 20.39 9.97 6 192081 12537 64294108
Myotonia 20.31 9.97 11 192076 217 64306428
Suicide attempt 20.25 9.97 126 191961 70881 64235764
Vasoconstriction 20.22 9.97 16 192071 612 64306033
Premature delivery 20.21 9.97 109 191978 18480 64288165
Foetal heart rate decreased 20.18 9.97 6 192081 20 64306625
Pneumococcal sepsis 20.04 9.97 22 192065 1282 64305363
Injection site rash 19.94 9.97 11 192076 15731 64290914
Head titubation 19.93 9.97 18 192069 827 64305818
Intestinal pseudo-obstruction 19.77 9.97 27 192060 1973 64304672
Hepatorenal syndrome 19.73 9.97 38 192049 3708 64302937
Vasoplegia syndrome 19.66 9.97 32 192055 2735 64303910
Cardiac failure 19.51 9.97 277 191810 132096 64174549
Post procedural haemorrhage 19.45 9.97 81 192006 12350 64294295
Muscle spasms 19.43 9.97 299 191788 140724 64165921
Coagulopathy 19.43 9.97 162 191925 31758 64274887
Manufacturing production issue 19.28 9.97 4 192083 0 64306645
Tongue disorder 19.23 9.97 6 192081 12074 64294571
Gastroenteritis 19.23 9.97 37 192050 29674 64276971
Joint injury 19.23 9.97 24 192063 22923 64283722
Non-small cell lung cancer 19.22 9.97 44 192043 4846 64301799
Eosinophil count increased 19.16 9.97 9 192078 14103 64292542
Substance dependence 19.12 9.97 14 192073 476 64306169
Inflammation 19.07 9.97 115 191972 65185 64241460
Dry skin 18.96 9.97 83 192004 51078 64255567
Seizure like phenomena 18.96 9.97 24 192063 1628 64305017
Intentional self-injury 18.95 9.97 36 192051 29008 64277637
Electrocardiogram ST segment depression 18.94 9.97 41 192046 4348 64302297
Acute myeloid leukaemia 18.84 9.97 33 192054 27430 64279215
Post transplant lymphoproliferative disorder 18.68 9.97 3 192084 9541 64297104
Aspergillus infection 18.59 9.97 13 192074 16366 64290279
Drug eruption 18.54 9.97 51 192036 36085 64270560
Product use in unapproved indication 18.49 9.97 393 191694 176225 64130420
Cardiac output decreased 18.37 9.97 24 192063 1680 64304965
Ear pain 18.36 9.97 29 192058 25107 64281538
Weight decreased 18.31 9.97 681 191406 285058 64021587
Sedation complication 18.23 9.97 70 192017 10284 64296361
Stridor 18.22 9.97 43 192044 4831 64301814
Urinary tract infection 18.13 9.97 538 191549 231058 64075587
Agranulocytosis 18.13 9.97 56 192031 38173 64268472
Pancreatitis acute 18.11 9.97 66 192021 42789 64263856
Hepatic failure 18.09 9.97 248 191839 55146 64251499
Mastocytosis 17.93 9.97 13 192074 435 64306210
Ventricular extrasystoles 17.87 9.97 101 191986 17428 64289217
Sinus congestion 17.86 9.97 12 192075 15427 64291218
Gastric cancer 17.80 9.97 51 192036 6442 64300203
Urticaria 17.79 9.97 320 191767 146997 64159648
Mechanical ventilation complication 17.78 9.97 6 192081 33 64306612
Tendon rupture 17.78 9.97 5 192082 10762 64295883
Status epilepticus 17.77 9.97 118 191969 21545 64285100
Bone marrow failure 17.65 9.97 78 192009 47874 64258771
Phrenic nerve paralysis 17.58 9.97 10 192077 218 64306427
Weight bearing difficulty 17.52 9.97 30 192057 2673 64303972
Heavy menstrual bleeding 17.51 9.97 7 192080 12070 64294575
Arterial haemorrhage 17.50 9.97 27 192060 2204 64304441
Ocular hyperaemia 17.48 9.97 25 192062 22539 64284106
Rectal haemorrhage 17.47 9.97 110 191977 61707 64244938
Postoperative respiratory distress 17.46 9.97 5 192082 14 64306631
Melaena 17.43 9.97 91 191996 53457 64253188
Uveitis 17.42 9.97 8 192079 12700 64293945
Uterine hypertonus 17.37 9.97 10 192077 223 64306422
Cardiac failure chronic 17.34 9.97 3 192084 9038 64297607
Product storage error 17.32 9.97 9 192078 13309 64293336
Limb injury 17.28 9.97 27 192060 23478 64283167
Ventricular arrhythmia 17.28 9.97 55 192032 7360 64299285
Diabetes mellitus inadequate control 17.15 9.97 23 192064 21298 64285347
Hypercapnic coma 17.13 9.97 12 192075 380 64306265
Pituitary apoplexy 17.07 9.97 9 192078 168 64306477
International normalised ratio increased 17.06 9.97 152 191935 79015 64227630
Gastrointestinal scarring 17.02 9.97 10 192077 232 64306413
Polyarthritis 17.02 9.97 4 192083 9711 64296934
Dehydration 17.00 9.97 799 191288 215964 64090681
Rash maculo-papular 17 9.97 77 192010 46949 64259696
Exposure via ingestion 16.98 9.97 42 192045 4860 64301785
Nodule 16.98 9.97 17 192070 17930 64288715
Blood pressure fluctuation 16.97 9.97 88 191999 51783 64254862
Myocardial ischaemia 16.92 9.97 123 191964 23128 64283517
Renal impairment 16.89 9.97 524 191563 134493 64172152
Skin sensitisation 16.85 9.97 16 192071 784 64305861
Acute chest syndrome 16.83 9.97 17 192070 899 64305746
Enthesopathy 16.82 9.97 4 192083 9634 64297011
Chest pain 16.82 9.97 555 191532 235425 64071220
Sphincter of Oddi dysfunction 16.72 9.97 12 192075 395 64306250
Product administration error 16.67 9.97 140 191947 27503 64279142
Drug detoxification 16.57 9.97 10 192077 244 64306401
Postpartum haemorrhage 16.57 9.97 21 192066 1426 64305219
Respiratory distress 16.57 9.97 233 191854 52098 64254547
Glycosylated haemoglobin increased 16.55 9.97 14 192073 16005 64290640
Visual acuity reduced 16.54 9.97 35 192052 27106 64279539
Dyspepsia 16.53 9.97 156 191931 80156 64226489
Respiratory tract infection bacterial 16.47 9.97 16 192071 807 64305838
Quadriplegia 16.41 9.97 31 192056 2982 64303663
Medical device site pain 16.36 9.97 10 192077 250 64306395
Blood ethanol 16.33 9.97 8 192079 127 64306518
Hyperlipidaemia 16.32 9.97 27 192060 22949 64283696
Cardiac massage 16.31 9.97 5 192082 19 64306626
Middle insomnia 16.31 9.97 9 192078 12868 64293777
Cyst 16.25 9.97 75 192012 11952 64294693
Stoma closure 16.22 9.97 8 192079 129 64306516
Toxic encephalopathy 16.18 9.97 65 192022 9750 64296895
Cholelithiasis 16.16 9.97 75 192012 45431 64261214
Rhythm idioventricular 16.14 9.97 13 192074 510 64306135
Tooth loss 16.10 9.97 48 192039 6199 64300446
Full blood count abnormal 16.02 9.97 41 192046 29716 64276929
Prinzmetal angina 15.94 9.97 21 192066 1482 64305163
Musculoskeletal discomfort 15.88 9.97 15 192072 16262 64290383
Troponin increased 15.88 9.97 89 191998 15310 64291335
Dyslipidaemia 15.81 9.97 4 192083 9238 64297407
Pneumonitis chemical 15.77 9.97 11 192076 346 64306299
Nystagmus 15.71 9.97 61 192026 9007 64297638
Postmortem blood drug level abnormal 15.69 9.97 14 192073 633 64306012
Blood glucose decreased 15.67 9.97 28 192059 23095 64283550
Exposure to extreme temperature 15.63 9.97 4 192083 6 64306639
Renal cyst 15.61 9.97 9 192078 12561 64294084
Pancreatic carcinoma metastatic 15.60 9.97 33 192054 3445 64303200
Acne 15.60 9.97 28 192059 23053 64283592
Intestinal ischaemia 15.59 9.97 72 192015 11477 64295168
Bezold-Jarisch reflex 15.55 9.97 5 192082 23 64306622
Chemical peritonitis 15.55 9.97 10 192077 274 64306371
Asthenia 15.47 9.97 1082 191005 426962 63879683
Joint range of motion decreased 15.42 9.97 21 192066 19322 64287323
Lymphadenopathy 15.39 9.97 79 192008 46607 64260038
Areflexia 15.38 9.97 41 192046 4966 64301679
Tachyarrhythmia 15.25 9.97 46 192041 5980 64300665
Sleep disorder due to a general medical condition 15.22 9.97 3 192084 8231 64298414
Pulmonary arterial hypertension 15.22 9.97 33 192054 25334 64281311
Foot fracture 15.21 9.97 19 192068 18138 64288507
Neutropenia 15.14 9.97 572 191515 239052 64067593
Gastric disorder 15.14 9.97 41 192046 29156 64277489
Hypogonadism 15.11 9.97 17 192070 1018 64305627
Vasculitis 15.09 9.97 19 192068 18076 64288569
Preternatural anus 15.07 9.97 7 192080 98 64306547
Blood pressure systolic increased 15.02 9.97 86 192001 49367 64257278
Eye irritation 15.02 9.97 15 192072 15841 64290804
Pancreatic carcinoma 15.00 9.97 66 192021 10307 64296338
Carpal tunnel syndrome 14.97 9.97 15 192072 15813 64290832
Interstitial lung disease 14.94 9.97 203 191884 97529 64209116
Oxidative stress 14.90 9.97 5 192082 27 64306618
Post-traumatic neck syndrome 14.90 9.97 23 192064 1879 64304766
Subcutaneous emphysema 14.82 9.97 21 192066 1588 64305057
Mydriasis 14.81 9.97 87 192000 15225 64291420
Therapy interrupted 14.75 9.97 23 192064 20013 64286632
Paralysis 14.71 9.97 71 192016 11524 64295121
Long QT syndrome 14.71 9.97 41 192046 5098 64301547
Asphyxia 14.70 9.97 62 192025 9504 64297141
Hyponatraemia 14.68 9.97 333 191754 148006 64158639
Swollen tongue 14.66 9.97 54 192033 34900 64271745
Atrioventricular block complete 14.65 9.97 83 192004 14335 64292310
Metastases to spine 14.56 9.97 33 192054 3610 64303035
Decorticate posture 14.55 9.97 10 192077 307 64306338
Acute respiratory failure 14.49 9.97 219 191868 49715 64256930
Peroneal nerve palsy postoperative 14.46 9.97 3 192084 0 64306645
Pulse pressure abnormal 14.46 9.97 3 192084 0 64306645
Drug effect faster than expected 14.46 9.97 3 192084 0 64306645
Application site perspiration 14.46 9.97 3 192084 0 64306645
Intentional overdose 14.41 9.97 185 191902 89759 64216886
Neuroendocrine tumour of the lung metastatic 14.41 9.97 7 192080 109 64306536
Spinal cord injury 14.40 9.97 16 192071 945 64305700
Conjunctivitis 14.38 9.97 24 192063 20330 64286315
Toxicologic test abnormal 14.38 9.97 18 192069 1207 64305438
Atrioventricular dissociation 14.32 9.97 10 192077 315 64306330
Blood catecholamines increased 14.32 9.97 5 192082 31 64306614
Hypermagnesaemia 14.31 9.97 17 192070 1080 64305565
Arthrofibrosis 14.29 9.97 7 192080 111 64306534
Tracheal deviation 14.20 9.97 6 192081 66 64306579
Spinal epidural haematoma 14.18 9.97 18 192069 1224 64305421
Endotracheal intubation 14.16 9.97 34 192053 3861 64302784
Product packaging issue 14.14 9.97 16 192071 964 64305681
Vein disorder 14.14 9.97 35 192052 4052 64302593
Infusion site mass 14.13 9.97 16 192071 965 64305680
Pulmonary toxicity 14.09 9.97 4 192083 8557 64298088
Epstein-Barr virus infection 14.06 9.97 10 192077 12478 64294167
Device dislocation 14.03 9.97 26 192061 21152 64285493
Anxiety 14.03 9.97 738 191349 201911 64104734
Hemiplegic migraine 13.97 9.97 6 192081 69 64306576
Locked-in syndrome 13.94 9.97 13 192074 623 64306022
Catecholamine crisis 13.93 9.97 5 192082 34 64306611
Metabolic encephalopathy 13.92 9.97 54 192033 7971 64298674
Extradural haematoma 13.92 9.97 27 192060 2649 64303996
Type I hypersensitivity 13.87 9.97 32 192055 3542 64303103
Gouty tophus 13.86 9.97 10 192077 332 64306313
Synovial cyst 13.85 9.97 3 192084 7704 64298941
Heart rate irregular 13.83 9.97 39 192048 27374 64279271
Suicidal ideation 13.80 9.97 129 191958 66413 64240232
Intervertebral disc compression 13.74 9.97 16 192071 995 64305650
Motor neurone disease 13.74 9.97 11 192076 428 64306217
Hot flush 13.73 9.97 81 192006 46154 64260491
Posturing 13.72 9.97 16 192071 996 64305649
Haematotoxicity 13.66 9.97 11 192076 12885 64293760
Acute graft versus host disease 13.61 9.97 5 192082 9079 64297566
Blood ethanol increased 13.56 9.97 13 192074 645 64306000
Lagophthalmos 13.55 9.97 10 192077 344 64306301
Dermal absorption impaired 13.53 9.97 4 192083 13 64306632
Agitation postoperative 13.52 9.97 6 192081 75 64306570
Sweat gland disorder 13.49 9.97 8 192079 189 64306456
Cardiac disorder 13.47 9.97 104 191983 55712 64250933
Environmental exposure 13.45 9.97 10 192077 348 64306297
Accidental poisoning 13.44 9.97 19 192068 1434 64305211
Pulmonary alveolar haemorrhage 13.36 9.97 61 192026 9677 64296968
Facial nerve disorder 13.34 9.97 13 192074 658 64305987
Medical device site fistula 13.34 9.97 5 192082 39 64306606
Manipulation 13.32 9.97 6 192081 78 64306567
Paraesthesia 13.31 9.97 302 191785 134220 64172425
Procedural vomiting 13.29 9.97 13 192074 661 64305984
Vitamin K deficiency 13.21 9.97 13 192074 666 64305979
Disseminated intravascular coagulation 13.21 9.97 151 191936 32197 64274448
Eye pruritus 13.15 9.97 11 192076 12648 64293997
Panniculitis 13.12 9.97 5 192082 8874 64297771
Respiratory alkalosis 13.09 9.97 33 192054 3864 64302781
Nerve stimulation test abnormal 13.09 9.97 4 192083 15 64306630
Coeliac disease 13.09 9.97 3 192084 7409 64299236
Foot deformity 13.07 9.97 18 192069 16486 64290159
Visual field defect 13.05 9.97 4 192083 8142 64298503
Procedural nausea 12.97 9.97 13 192074 681 64305964
Hypercreatininaemia 12.96 9.97 14 192073 801 64305844
Post procedural haematoma 12.96 9.97 24 192063 2274 64304371
Skin cancer 12.95 9.97 10 192077 11964 64294681
Yawning 12.91 9.97 17 192070 1199 64305446
Mucormycosis 12.91 9.97 3 192084 7338 64299307
Hepatic cirrhosis 12.84 9.97 38 192049 26260 64280385
Squamous cell carcinoma of skin 12.74 9.97 10 192077 11866 64294779
Tracheal pain 12.72 9.97 5 192082 45 64306600
Intensive care unit delirium 12.72 9.97 5 192082 45 64306600
Faeces discoloured 12.69 9.97 37 192050 25692 64280953
Eastern Cooperative Oncology Group performance status worsened 12.56 9.97 17 192070 1231 64305414
Capillary nail refill test abnormal 12.53 9.97 5 192082 47 64306598
Hypophonesis 12.51 9.97 4 192083 18 64306627
Second primary malignancy 12.48 9.97 11 192076 12326 64294319
Laryngeal oedema 12.45 9.97 48 192039 7065 64299580
Skin haemorrhage 12.41 9.97 5 192082 8580 64298065
Hippocampal atrophy 12.39 9.97 3 192084 3 64306642
Sopor 12.36 9.97 139 191948 29522 64277123
Psychomotor skills impaired 12.34 9.97 32 192055 3813 64302832
Food allergy 12.32 9.97 4 192083 7847 64298798
End stage renal disease 12.31 9.97 8 192079 10467 64296178
Wound dehiscence 12.28 9.97 42 192045 5832 64300813
Laryngeal cancer metastatic 12.26 9.97 5 192082 50 64306595
Abdominal compartment syndrome 12.22 9.97 18 192069 1410 64305235
Leukopenia 12.19 9.97 220 191867 101022 64205623
Aspiration 12.10 9.97 89 191998 16796 64289849
Large intestine anastomosis 12.09 9.97 6 192081 98 64306547
Mean arterial pressure increased 12.08 9.97 5 192082 52 64306593
Pharyngitis 12.07 9.97 24 192063 19015 64287630
Low density lipoprotein increased 12.05 9.97 4 192083 7736 64298909
Haematochezia 11.98 9.97 133 191954 66240 64240405
Drug specific antibody 11.96 9.97 22 192065 2073 64304572
Hypercholesterolaemia 11.94 9.97 17 192070 15356 64291289
Atelectasis 11.92 9.97 129 191958 27137 64279508
Hypovolaemia 11.89 9.97 83 192004 15403 64291242
Meningococcal bacteraemia 11.86 9.97 4 192083 22 64306623
Fungal infection 11.84 9.97 57 192030 34194 64272451
Pollakiuria 11.78 9.97 51 192036 31479 64275166
Disease recurrence 11.75 9.97 51 192036 31459 64275186
Rhabdomyolysis 11.74 9.97 357 191730 91369 64215276
Blood urine present 11.73 9.97 23 192064 18317 64288328
Uterine atony 11.70 9.97 7 192080 168 64306477
Forced expiratory volume decreased 11.69 9.97 3 192084 6864 64299781
Hypotonia 11.69 9.97 65 192022 11147 64295498
Skin plaque 11.69 9.97 6 192081 8934 64297711
Ketoacidosis 11.68 9.97 3 192084 6860 64299785
Generalised onset non-motor seizure 11.68 9.97 5 192082 57 64306588
Oesophageal intramural haematoma 11.67 9.97 6 192081 106 64306539
Therapeutic response shortened 11.64 9.97 8 192079 10162 64296483
Ileus 11.64 9.97 112 191975 22854 64283791
Rhinitis 11.63 9.97 9 192078 10756 64295889
Infusion site haemorrhage 11.61 9.97 23 192064 2292 64304353
Blood pressure diastolic increased 11.60 9.97 9 192078 10743 64295902
Colorectal cancer 11.59 9.97 28 192059 3193 64303452
Euthyroid sick syndrome 11.53 9.97 5 192082 59 64306586
Laryngeal obstruction 11.52 9.97 6 192081 109 64306536
Exposure via breast milk 11.52 9.97 13 192074 781 64305864
Proteinuria 11.52 9.97 43 192044 27680 64278965
Breast cancer metastatic 11.44 9.97 47 192040 7122 64299523
Dysphonia 11.39 9.97 86 192001 46296 64260349
Joint effusion 11.39 9.97 14 192073 13459 64293186
Unintentional medical device removal 11.36 9.97 3 192084 6731 64299914
Spinal cord oedema 11.35 9.97 9 192078 345 64306300
Drug dose titration not performed 11.33 9.97 12 192075 671 64305974
Pathological fracture 11.32 9.97 55 192032 8950 64297695
Metastatic neoplasm 11.32 9.97 34 192053 4408 64302237
Oedema 11.31 9.97 199 191888 91736 64214909
Bronchopulmonary aspergillosis 11.31 9.97 25 192062 19060 64287585
Respiratory paralysis 11.31 9.97 5 192082 62 64306583
Infrequent bowel movements 11.29 9.97 17 192070 1358 64305287
Optic neuritis 11.29 9.97 5 192082 8111 64298534
Colitis microscopic 11.29 9.97 4 192083 7428 64299217
Feeling cold 11.28 9.97 114 191973 23564 64283081
Decerebrate posture 11.28 9.97 7 192080 180 64306465
Procedural haemorrhage 11.27 9.97 33 192054 4219 64302426
Motor dysfunction 11.24 9.97 65 192022 11308 64295337
Myocardial stunning 11.24 9.97 7 192080 181 64306464
Sympatholysis 11.18 9.97 3 192084 6 64306639
Haematuria traumatic 11.17 9.97 7 192080 183 64306462
Nausea 11.16 9.97 2571 189516 783229 63523416
Hypoaesthesia 11.16 9.97 322 191765 138786 64167859
Thyroid disorder 11.15 9.97 11 192076 11681 64294964
Blood pressure systolic abnormal 11.14 9.97 8 192079 9934 64296711
Tumour haemorrhage 11.14 9.97 29 192058 3464 64303181
Burkholderia test positive 11.11 9.97 11 192076 568 64306077
Monoparesis 11.09 9.97 26 192061 2908 64303737
Lip swelling 11.09 9.97 53 192034 31854 64274791
Parkinsonism 11.06 9.97 16 192071 14357 64292288
Rash pustular 11.02 9.97 8 192079 9877 64296768
Sinus disorder 10.99 9.97 21 192066 16887 64289758
Impaired healing 10.98 9.97 121 191966 60352 64246293
Jaundice 10.96 9.97 92 191995 48420 64258225
Eye disorder 10.95 9.97 25 192062 18844 64287801
Refusal of treatment by relative 10.95 9.97 12 192075 698 64305947
Nerve block 10.90 9.97 9 192078 366 64306279
Ischaemic cerebral infarction 10.89 9.97 21 192066 2051 64304594
Drug screen negative 10.87 9.97 8 192079 274 64306371
Clinical trial participant 10.83 9.97 6 192081 124 64306521
Bacterial infection 10.83 9.97 38 192049 24912 64281733
Pulmonary fibrosis 10.75 9.97 49 192038 29829 64276816
Ankle fracture 10.72 9.97 17 192070 14693 64291952
Cutaneous vasculitis 10.70 9.97 3 192084 6470 64300175
Physical product label issue 10.69 9.97 4 192083 31 64306614
Device use error 10.69 9.97 3 192084 6468 64300177
Gastrointestinal haemorrhage 10.68 9.97 306 191781 132006 64174639
Premature separation of placenta 10.64 9.97 15 192072 1129 64305516
Mouth ulceration 10.64 9.97 55 192032 32389 64274256
Myopathy 10.61 9.97 23 192064 17657 64288988
Influenza like illness 10.60 9.97 125 191962 61577 64245068
Gonadotrophin deficiency 10.58 9.97 4 192083 32 64306613
Respiratory tract congestion 10.58 9.97 20 192067 16145 64290500
Lymphopenia 10.52 9.97 40 192047 25617 64281028
Hypertonia 10.52 9.97 42 192045 6283 64300362
Treatment noncompliance 10.50 9.97 81 192006 43401 64263244
Urticaria papular 10.50 9.97 6 192081 132 64306513
Bile output abnormal 10.48 9.97 4 192083 33 64306612
Implant site extravasation 10.46 9.97 12 192075 734 64305911
Device failure 10.45 9.97 39 192048 5653 64300992
Gout 10.41 9.97 31 192056 21382 64285263
Monoplegia 10.38 9.97 28 192059 3415 64303230
Urine amphetamine positive 10.34 9.97 5 192082 77 64306568
Paroxysmal atrioventricular block 10.33 9.97 3 192084 9 64306636
Excessive dynamic airway collapse 10.33 9.97 3 192084 9 64306636
Fear of death 10.33 9.97 16 192071 1311 64305334
Post laminectomy syndrome 10.31 9.97 8 192079 297 64306348
Phaeochromocytoma crisis 10.27 9.97 8 192079 299 64306346
Throat tightness 10.23 9.97 35 192052 23125 64283520
Intraocular pressure increased 10.23 9.97 6 192081 8296 64298349
Secondary adrenocortical insufficiency 10.23 9.97 22 192065 2323 64304322
Uterine hypotonus 10.23 9.97 5 192082 79 64306566
Chronic graft versus host disease 10.20 9.97 3 192084 6273 64300372
Diplopia 10.17 9.97 43 192044 26722 64279923
Cancer fatigue 10.17 9.97 5 192082 80 64306565
Listless 10.17 9.97 27 192060 3263 64303382
Oculogyric crisis 10.15 9.97 23 192064 2515 64304130
Ankylosing spondylitis 10.15 9.97 50 192037 8184 64298461
Antinuclear antibody positive 10.14 9.97 3 192084 6247 64300398
Lacrimation increased 10.09 9.97 25 192062 18321 64288324
Skin test positive 10.08 9.97 14 192073 1039 64305606
Therapeutic response decreased 10.05 9.97 103 191984 52085 64254560
Therapeutic product effect decreased 10.03 9.97 264 191823 115087 64191558
Amylase increased 10 9.97 56 192031 9629 64297016
Pancytopenia 9.98 9.97 338 191749 142971 64163674
Stupor 9.97 9.97 40 192047 5995 64300650

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle rigidity 48.63 29.60 11 290 3 84374
Intraventricular haemorrhage 32.24 29.60 14 287 140 84237

Pharmacologic Action:

SourceCodeDescription
ATC N01AH01 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
ATC N01AH51 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
ATC N02AB03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Phenylpiperidine derivatives
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:55322 mu-opioid agonists
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:38877 intravenous anesthetics
CHEBI has role CHEBI:60807 anaesthestic adjuvant
CHEBI has role CHEBI:60809 adjuvants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
General anesthesia indication 50697003
Local anesthesia indication 386761002
Breakthrough cancer pain indication 879973007
Acute postoperative pain indication 107401000119105
Regional Anesthesia for Surgery indication
Chronic Pain with Opioid Tolerance indication
Regional Anesthesia for Postoperative Pain indication
Breakthrough Pain in Opioid Tolerant Patients indication
Anesthesia for cesarean section off-label use 4847005
Severe pain off-label use 76948002
Conscious sedation off-label use 314271007
Regional Anesthesia for Labor Pain off-label use
Sedation in Intubated Patients off-label use
Alcoholism contraindication 7200002
Cardiomegaly contraindication 8186001
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Decreased cardiac function contraindication 43650005
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Paralytic ileus contraindication 55525008 DOID:8442
Hepatic failure contraindication 59927004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Extrapyramidal disease contraindication 76349003
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of biliary tract contraindication 105997008 DOID:9741
Prolonged QT interval contraindication 111975006
Procedure on urinary system contraindication 118677009
Hypomagnesemia contraindication 190855004
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Headache disorder contraindication 230461009
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Lesion of brain contraindication 301766008
Pheochromocytoma contraindication 302835009
Deficiency of cholinesterase contraindication 360607009
Central nervous system depression contraindication 418072004
Congenital long QT syndrome contraindication 442917000
Acute exacerbation of asthma contraindication 708038006
Headache Pain especially in Patients who are not Opiate Tolerant contraindication
Pain in Opioid Naive Patients contraindication
Refractory Extrinsic Asthma contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Dogs Postoperative pain associated with surgical procedures Indication
Dogs Analgesia and tranquilizers Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Innovar-Vet Injection Intervet Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.62 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 40MCG BASE/ACTIVATION IONSYS THE MEDICINES CO N021338 May 22, 2006 DISCN SYSTEM IONTOPHORESIS, TRANSDERMAL 6881208 April 19, 2022 METHOD FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF FENTANYL HYDROCHLORIDE
EQ 0.1MG BASE LAZANDA BTCP PHARMA N022569 June 30, 2011 RX SPRAY, METERED NASAL 8889176 Jan. 16, 2024 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.4MG BASE LAZANDA BTCP PHARMA N022569 June 30, 2011 RX SPRAY, METERED NASAL 8889176 Jan. 16, 2024 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.1MG BASE LAZANDA BTCP PHARMA N022569 June 30, 2011 RX SPRAY, METERED NASAL 8216604 Oct. 3, 2024 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.4MG BASE LAZANDA BTCP PHARMA N022569 June 30, 2011 RX SPRAY, METERED NASAL 8216604 Oct. 3, 2024 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
0.1MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
0.1MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
0.1MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
0.2MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
0.2MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
0.2MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
0.4MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
0.4MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
0.4MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
0.6MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
0.6MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
0.6MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
0.8MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
0.8MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
0.8MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
1.2MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
1.2MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
1.2MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
1.6MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 8835460 Jan. 25, 2027 TREATMENT OF PAIN
1.6MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 9289387 Jan. 25, 2027 TREATMENT OF PAIN
1.6MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 9642797 Jan. 25, 2027 TREATMENT OF PAIN
EQ 0.2MG BASE ONSOLIS BDSI N022266 July 16, 2009 DISCN FILM BUCCAL 9597288 July 23, 2027 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.4MG BASE ONSOLIS BDSI N022266 July 16, 2009 DISCN FILM BUCCAL 9597288 July 23, 2027 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.6MG BASE ONSOLIS BDSI N022266 July 16, 2009 DISCN FILM BUCCAL 9597288 July 23, 2027 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 0.8MG BASE ONSOLIS BDSI N022266 July 16, 2009 DISCN FILM BUCCAL 9597288 July 23, 2027 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
EQ 1.2MG BASE ONSOLIS BDSI N022266 July 16, 2009 DISCN FILM BUCCAL 9597288 July 23, 2027 MANAGEMENT OF BREAKTHROUGH PAIN IN PATIENTS WITH CANCER
0.1MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
0.2MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
0.4MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
0.6MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
0.8MG SUBSYS BTCP PHARMA N202788 Jan. 4, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
1.2MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
1.6MG SUBSYS BTCP PHARMA N202788 Aug. 30, 2012 RX SPRAY SUBLINGUAL 8486973 April 27, 2030 TREATMENT OF PAIN
EQ 40MCG BASE/ACTIVATION IONSYS THE MEDICINES CO N021338 May 22, 2006 DISCN SYSTEM IONTOPHORESIS, TRANSDERMAL 9364656 Sept. 30, 2031 METHOD FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF FENTANYL HYDROCHLORIDE
EQ 40MCG BASE/ACTIVATION IONSYS THE MEDICINES CO N021338 May 22, 2006 DISCN SYSTEM IONTOPHORESIS, TRANSDERMAL 8781571 March 31, 2032 METHOD FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF FENTANYL HYDROCHLORIDE
EQ 40MCG BASE/ACTIVATION IONSYS THE MEDICINES CO N021338 May 22, 2006 DISCN SYSTEM IONTOPHORESIS, TRANSDERMAL 8428708 May 21, 2032 METHOD FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF FENTANYL HYDROCHLORIDE
EQ 40MCG BASE/ACTIVATION IONSYS THE MEDICINES CO N021338 May 22, 2006 DISCN SYSTEM IONTOPHORESIS, TRANSDERMAL 8428709 June 11, 2032 METHOD FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF FENTANYL HYDROCHLORIDE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST EC50 9.00 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.45 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.74 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.71 CHEMBL
Delta-type opioid receptor GPCR Ki 6.17 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.34 CHEMBL
Monoamine oxidase Enzyme Ki 5.26 CHEMBL
Mu-type opioid receptor GPCR Ki 8.82 CHEMBL
Mu-type opioid receptor GPCR Ki 8.23 CHEMBL
Mu-type opioid receptor GPCR Ki 8.07 CHEMBL
Delta-type opioid receptor GPCR IC50 8.03 CHEMBL
Delta-type opioid receptor GPCR Ki 6.40 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.71 CHEMBL
Histamine H1 receptor GPCR IC50 4.70 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other IC50 5.30 CHEMBL
Opioid receptor GPCR Ki 8.67 CHEMBL

External reference:

IDSource
4018745 VUID
N0000147049 NUI
D00320 KEGG_DRUG
990-73-8 SECONDARY_CAS_RN
1443-54-5 SECONDARY_CAS_RN
4018744 VANDF
4018745 VANDF
C0015846 UMLSCUI
CHEBI:119915 CHEBI
7V7 PDB_CHEM_ID
CHEMBL688 ChEMBL_ID
CHEMBL596 ChEMBL_ID
DB00813 DRUGBANK_ID
D005283 MESH_DESCRIPTOR_UI
3345 PUBCHEM_CID
1626 IUPHAR_LIGAND_ID
1608 INN_ID
UF599785JZ UNII
142436 RXNORM
29441 MMSL
4632 MMSL
4721 MMSL
4722 MMSL
64408 MMSL
d00233 MMSL
001568 NDDF
003571 NDDF
011514 NDDF
29190006 SNOMEDCT_US
373492002 SNOMEDCT_US
40648001 SNOMEDCT_US
CHEMBL1201159 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7865 LOZENGE 200 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7866 LOZENGE 400 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7867 LOZENGE 600 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7868 LOZENGE 800 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7869 LOZENGE 1200 ug ORAL NDA authorized generic 33 sections
Fentanyl Citrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-7870 LOZENGE 1600 ug ORAL NDA authorized generic 33 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9119 PATCH 12 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9121 PATCH 25 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9122 PATCH 50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9123 PATCH 75 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9124 PATCH 100 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9125 PATCH 37.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9126 PATCH 62.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL HUMAN PRESCRIPTION DRUG LABEL 1 0378-9127 PATCH 87.50 ug TRANSDERMAL ANDA 34 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9000 PATCH, EXTENDED RELEASE 100 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9012 PATCH, EXTENDED RELEASE 12.50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9025 PATCH, EXTENDED RELEASE 25 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9037 PATCH, EXTENDED RELEASE 37.50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9050 PATCH, EXTENDED RELEASE 50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9062 PATCH, EXTENDED RELEASE 62.50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9075 PATCH, EXTENDED RELEASE 75 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9100 PATCH, EXTENDED RELEASE 100 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9112 PATCH, EXTENDED RELEASE 12.50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9125 PATCH, EXTENDED RELEASE 25 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9150 PATCH, EXTENDED RELEASE 50 ug TRANSDERMAL ANDA 38 sections
FENTANYL TRANSDERMAL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9175 PATCH, EXTENDED RELEASE 75 ug TRANSDERMAL ANDA 38 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9202 LOZENGE 200 ug TRANSMUCOSAL ANDA 34 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9204 LOZENGE 400 ug TRANSMUCOSAL ANDA 34 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9206 LOZENGE 600 ug TRANSMUCOSAL ANDA 34 sections
FENTANYL CITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-9208 LOZENGE 800 ug TRANSMUCOSAL ANDA 34 sections