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phenoperidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analgesics, pethidine derivatives and other synthetic small molecule miu-opioid receptor agonists | 3441 | 562-26-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 5.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 22 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.22 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.983 | Moderate | 0.67 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.785 | Moderate | 0.67 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 34.834 | 10^-6 cm/s | Moderate | 0.67 |
| dh-clint | Dog hepatocyte intrinsic clearance | 28.379 | uL/min/10^6 cells | Moderate | 0.67 |
| dppb | Dog plasma protein binding (% unbound) | 14.720 | % | Moderate | 0.67 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 26.550 | % | Moderate | 0.67 |
| herg | hERG pIC50 | 5.397 | pIC50 | Moderate | 0.67 |
| hh-clint | Human hepatocyte intrinsic clearance | 34.754 | uL/min/10^6 cells | Moderate | 0.67 |
| hlm-clint | Human liver microsomal intrinsic clearance | 158.489 | uL/min/mg protein | Moderate | 0.67 |
| hppb | Human plasma protein binding (% unbound) | 14.400 | % | Moderate | 0.67 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK | 46 | |||
| kinase-selectivity-class | AKT3,AXL,EIF2AK3,EPHB4,GRK2,PDK4,SIK2 | 7 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.014 | Moderate | 0.67 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 148.252 | Moderate | 0.67 | |
| mppb | Mouse plasma protein binding (% unbound) | 14.600 | Moderate | 0.67 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.207 | Moderate | 0.67 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 27 | % | Moderate | 0.67 |
| rh-clint | Rat hepatocyte intrinsic clearance | 173.380 | uL/min/10^6 cells | Moderate | 0.67 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 51.150 | % | Moderate | 0.67 |
| rppb | Rat plasma protein binding (% unbound) | 14.660 | % | Moderate | 0.67 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 542.001 | uM | Moderate | 0.67 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N01AH04 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Opioid anesthetics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018689 | Sensory System Agents |
Related Drugs by ATC class:
N01AH Opioid anesthetics 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167337 | NUI |
| D02611 | KEGG_DRUG |
| C0031432 | UMLSCUI |
| CHEBI:135550 | CHEBI |
| CHEMBL2105385 | ChEMBL_ID |
| DB13605 | DRUGBANK_ID |
| D010638 | MESH_DESCRIPTOR_UI |
| 11226 | PUBCHEM_CID |
| 1062 | INN_ID |
| 3627-49-4 | SECONDARY_CAS_RN |
| G9BH09J4JW | UNII |
| 106508 | RXNORM |
| 004020 | NDDF |
| 004021 | NDDF |
| 350306009 | SNOMEDCT_US |
| 420076001 | SNOMEDCT_US |
Pharmaceutical products:
None