lypressin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasoconstrictors, vasopressin derivatives 2959 50-57-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lypressin
  • lysine pitressin
  • lysine vasopressin
  • lysipressin
  • lysopressin
  • lysylvasopressin
  • syntopressin
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
  • Molecular weight: 1056.23
  • Formula: C46H65N13O12S2
  • CLOGP: -2.45
  • LIPINSKI: 3
  • HAC: 25
  • HDO: 13
  • TPSA: 425.55
  • ALOGS: -4.33
  • ROTB: 19

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 U N
20 U P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01BA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
POSTERIOR PITUITARY LOBE HORMONES
Vasopressin and analogues
MeSH PA D050034 Antidiuretic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D003029 Coagulants
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
MeSH PA D045283 Natriuretic Agents
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Partial Central Diabetes Insipidus indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.65 acidic
pKa2 12.19 acidic
pKa3 12.56 acidic
pKa4 12.85 acidic
pKa5 13.19 acidic
pKa6 13.71 acidic
pKa7 13.76 acidic
pKa8 13.84 acidic
pKa9 10.31 Basic
pKa10 6.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vasopressin receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

IDSource
4018755 VUID
N0000147058 NUI
C0024328 UMLSCUI
D00366 KEGG_DRUG
7CZF3L922Y UNII
1481 INN_ID
4018755 VANDF
418230009 SNOMEDCT_US
6531 RXNORM
002124 NDDF
CHEMBL1200690 ChEMBL_ID
CHEBI:6603 CHEBI
D008236 MESH_DESCRIPTOR_UI
DB14642 DRUGBANK_ID
644076 PUBCHEM_CID

Pharmaceutical products:

None