lypressin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vasopressin analogues	2959	50-57-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lypressin lysine pitressin lysine vasopressin lysipressin lysopressin lysylvasopressin syntopressin	The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE. Molecular weight: 1056.23 Formula: C46H65N13O12S2 CLOGP: -1.74 LIPINSKI: 3 HAC: 25 HDO: 13 TPSA: 425.55 ALOGS: -4.33 ROTB: 19 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lypressin
lysine pitressin
lysine vasopressin
lysipressin
lysopressin
lysylvasopressin
syntopressin

The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.

Molecular weight: 1056.23
Formula: C46H65N13O12S2
CLOGP: -1.74
LIPINSKI: 3
HAC: 25
HDO: 13
TPSA: 425.55
ALOGS: -4.33
ROTB: 19

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
20	U	N
20	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	H01BA03	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES POSTERIOR PITUITARY LOBE HORMONES Vasopressin and analogues
MeSH PA	D050034	Antidiuretic Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D003029	Coagulants
MeSH PA	D006401	Hematologic Agents
MeSH PA	D006490	Hemostatics
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D014662	Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Partial Central Diabetes Insipidus	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.65	acidic
pKa2	12.19	acidic
pKa3	12.56	acidic
pKa4	12.85	acidic
pKa5	13.19	acidic
pKa6	13.71	acidic
pKa7	13.76	acidic
pKa8	13.84	acidic
pKa9	10.31	Basic
pKa10	6.4	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vasopressin receptor	GPCR	P30518 P37288 P47901	V2R_HUMAN V1AR_HUMAN V1BR_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4018755	VUID
N0000147058	NUI
D00366	KEGG_DRUG
4018755	VANDF
C0024328	UMLSCUI
CHEBI:6603	CHEBI
CHEMBL1200690	ChEMBL_ID
D008236	MESH_DESCRIPTOR_UI
DB14642	DRUGBANK_ID
1481	INN_ID
7CZF3L922Y	UNII
644076	PUBCHEM_CID
6531	RXNORM
002124	NDDF
418230009	SNOMEDCT_US

Pharmaceutical products:

None