terlipressin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vasoconstrictors, vasopressin derivatives | 2967 | 14636-12-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 12 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.24 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 8.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H01BA04 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES POSTERIOR PITUITARY LOBE HORMONES Vasopressin and analogues |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014662 | Vasoconstrictor Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.65 | acidic |
| pKa2 | 11.89 | acidic |
| pKa3 | 12.32 | acidic |
| pKa4 | 12.71 | acidic |
| pKa5 | 12.98 | acidic |
| pKa6 | 13.08 | acidic |
| pKa7 | 13.57 | acidic |
| pKa8 | 13.58 | acidic |
| pKa9 | 13.67 | acidic |
| pKa10 | 13.96 | acidic |
| pKa11 | 10.31 | Basic |
| pKa12 | 7.93 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D06672 | KEGG_DRUG |
| C0145185 | UMLSCUI |
| CHEBI:135905 | CHEBI |
| CHEMBL2135460 | ChEMBL_ID |
| D000077585 | MESH_DESCRIPTOR_UI |
| DB02638 | DRUGBANK_ID |
| 11241 | IUPHAR_LIGAND_ID |
| 5114 | INN_ID |
| 7Z5X49W53P | UNII |
| 72081 | PUBCHEM_CID |
| 57048 | RXNORM |
| 004053 | NDDF |
| 325927008 | SNOMEDCT_US |
| 395899009 | SNOMEDCT_US |
Pharmaceutical products:
None