Stem definition | Drug id | CAS RN |
---|---|---|
vasoconstrictors, vasopressin derivatives | 2810 | 113-79-1 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA | PARKE DAVIS |
None
None
Source | Code | Description |
---|---|---|
MeSH PA | D050034 | Antidiuretic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D003029 | Coagulants |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D006490 | Hemostatics |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D014662 | Vasoconstrictor Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nocturnal enuresis | indication | 8009008 | |
Hereditary factor VIII deficiency disease | indication | 28293008 | DOID:12134 |
von Willebrand disorder | indication | 128105004 | DOID:12531 |
Partial Central Diabetes Insipidus | indication | ||
Cardiac arrest | off-label use | 410429000 | DOID:0060319 |
Uremic Bleeding Tendency | off-label use | ||
Chronic glomerulonephritis | contraindication | 20917003 | |
Migraine | contraindication | 37796009 | DOID:6364 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Uremia | contraindication | 44730006 | DOID:4676 |
Heart failure | contraindication | 84114007 | DOID:6000 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Asthma | contraindication | 195967001 | DOID:2841 |
Disorder of coronary artery | contraindication | 414024009 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.65 | acidic |
pKa2 | 12.19 | acidic |
pKa3 | 12.56 | acidic |
pKa4 | 12.85 | acidic |
pKa5 | 13.19 | acidic |
pKa6 | 13.43 | acidic |
pKa7 | 13.76 | acidic |
pKa8 | 10.75 | Basic |
pKa9 | 6.4 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
200UNITS/10ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | Dec. 17, 2016 | RX | SOLUTION | INTRAVENOUS | 9375478 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
200UNITS/10ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | Dec. 17, 2016 | RX | SOLUTION | INTRAVENOUS | 9687526 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
200UNITS/10ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | Dec. 17, 2016 | RX | SOLUTION | INTRAVENOUS | 9744209 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
200UNITS/10ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | Dec. 17, 2016 | RX | SOLUTION | INTRAVENOUS | 9744239 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
200UNITS/10ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | Dec. 17, 2016 | RX | SOLUTION | INTRAVENOUS | 9937223 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
20UNITS/ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | April 17, 2014 | RX | SOLUTION | INTRAVENOUS | 9375478 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
20UNITS/ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | April 17, 2014 | RX | SOLUTION | INTRAVENOUS | 9687526 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
20UNITS/ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | April 17, 2014 | RX | SOLUTION | INTRAVENOUS | 9744209 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
20UNITS/ML (20UNITS/ML) | VASOSTRICT | PAR STERILE PRODUCTS | N204485 | April 17, 2014 | RX | SOLUTION | INTRAVENOUS | 9744239 | Jan. 30, 2035 | TO INCREASE BLOOD PRESSURE IN ADULTS WITH VASODILATORY SHOCK (E.G., POST-CARDIOTOMY OR SEPSIS) WHO REMAIN HYPOTENSIVE DESPITE FLUIDS AND CATECHOLAMINES |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Vasopressin V1b receptor | GPCR | AGONIST | Ki | 9.31 | CHEMBL | CHEMBL | |||
Vasopressin V2 receptor | GPCR | AGONIST | Ki | 8.92 | CHEMBL | CHEMBL | |||
Vasopressin V1a receptor | GPCR | AGONIST | Ki | 9.59 | CHEMBL | CHEMBL | |||
Oxytocin receptor | GPCR | Ki | 8.78 | CHEMBL | |||||
Vasopressin V2 receptor | GPCR | Kd | 8.82 | CHEMBL | |||||
Vasopressin V1b receptor | GPCR | Ki | 9.54 | CHEMBL | |||||
Vasopressin V1a receptor | GPCR | Kd | 9.19 | CHEMBL | |||||
Vasopressin V1 receptor | GPCR | Kd | 9.19 | CHEMBL | |||||
Vasopressin V2 receptor | GPCR | IC50 | 8.48 | CHEMBL | |||||
Oxytocin receptor | GPCR | Ki | 8.93 | CHEMBL | |||||
Vasopressin V2 receptor | GPCR | Ki | 9.35 | CHEMBL |
ID | Source |
---|---|
4018654 | VUID |
N0000179795 | NUI |
C1705480 | UMLSCUI |
D00101 | KEGG_DRUG |
4R069M4O1P | UNII |
77671006 | SNOMEDCT_US |
772208008 | SNOMEDCT_US |
4018654 | VANDF |
11149 | RXNORM |
3144 | MMSL |
5667 | MMSL |
d00398 | MMSL |
002126 | NDDF |
002122 | NDDF |
CHEMBL373742 | ChEMBL_ID |
DB00067 | DRUGBANK_ID |
CHEBI:9937 | CHEBI |
1482 | INN_ID |
CHEMBL1201528 | ChEMBL_ID |
CHEMBL2108986 | ChEMBL_ID |
644077 | PUBCHEM_CID |
2168 | IUPHAR_LIGAND_ID |
C016671 | MESH_SUPPLEMENTAL_RECORD_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
VASOPRESSIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-302 | INJECTION, SOLUTION | 20 [USP'U] | INTRAMUSCULAR | unapproved drug other | 10 sections |
Vasopressin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-302 | INJECTION, SOLUTION | 20 [USP'U] | INTRAMUSCULAR | unapproved drug other | 11 sections |