retinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2831 68-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin A1
  • vitamin A
  • retinol
  • retinol (vit A)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
  • Molecular weight: 286.46
  • Formula: C20H30O
  • CLOGP: 6.40
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -4.58
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 TU O
50 TU P
800 U N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 237.00 15.14 112 8431 30892 50565689
Coma 168.43 15.14 110 8433 56769 50539812
Gastrooesophageal reflux disease 158.95 15.14 119 8424 76309 50520272
Blood magnesium increased 123.85 15.14 37 8506 2843 50593738
Pleural thickening 123.18 15.14 36 8507 2563 50594018
Somnolence 118.38 15.14 138 8405 154847 50441734
Presbyacusis 116.50 15.14 35 8508 2741 50593840
Pleural fibrosis 113.81 15.14 36 8507 3348 50593233
Deafness neurosensory 107.60 15.14 37 8506 4464 50592117
Epigastric discomfort 94.40 15.14 36 8507 5834 50590747
Cyst 74.95 15.14 38 8505 12149 50584432
Osteopenia 63.07 15.14 38 8505 16980 50579601
Blood potassium increased 61.77 15.14 37 8506 16361 50580220
Skin lesion 56.29 15.14 42 8501 26685 50569896
Dry eye 51.57 15.14 43 8500 32052 50564529
Bone cyst 42.08 15.14 15 8528 2009 50594572
Choanal stenosis 35.90 15.14 6 8537 27 50596554
Blood creatinine increased 35.02 15.14 53 8490 76107 50520474
Osteosclerosis 34.25 15.14 15 8528 3452 50593129
Enterobacter infection 31.87 15.14 12 8531 1876 50594705
Infective pulmonary exacerbation of cystic fibrosis 30.18 15.14 18 8525 7891 50588690
Granulomatous liver disease 29.59 15.14 9 8534 734 50595847
Osteoarthritis 27.72 15.14 45 8498 68561 50528020
Aorta hypoplasia 27.04 15.14 6 8537 139 50596442
Exostosis 26.07 15.14 19 8524 11634 50584947
Underdose 24.26 15.14 23 8520 20255 50576326
Gastrointestinal disorder 23.16 15.14 50 8493 94406 50502175
Osteochondritis 22.97 15.14 4 8539 24 50596557
Deformity 22.58 15.14 15 8528 7925 50588656
Renal impairment 22.02 15.14 43 8500 75618 50520963
Sleep disorder 19.73 15.14 35 8508 57248 50539333
Tracheo-oesophageal fistula 19.28 15.14 6 8537 528 50596053
Malabsorption 18.35 15.14 10 8533 3696 50592885
Bone hypertrophy 16.96 15.14 5 8538 366 50596215
Anomaly of external ear congenital 15.71 15.14 4 8539 169 50596412
Hiatus hernia strangulated 15.71 15.14 4 8539 169 50596412
Treatment failure 15.69 15.14 55 8488 137582 50458999
Hepatic cirrhosis 15.65 15.14 17 8526 17560 50579021
Oesophageal atresia 15.24 15.14 5 8538 522 50596059

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infective pulmonary exacerbation of cystic fibrosis 55.79 17.34 22 3121 6214 29565170
Coronavirus infection 17.41 17.34 8 3135 3280 29568104
Febrile convulsion 17.35 17.34 5 3138 540 29570844

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 185.16 13.75 113 9432 59158 64430029
Gastrooesophageal reflux disease 168.52 13.75 121 9424 83022 64406165
Coma 147.33 13.75 114 9431 87501 64401686
Somnolence 121.63 13.75 150 9395 203495 64285692
Presbyacusis 105.79 13.75 31 9514 2544 64486643
Pleural thickening 104.23 13.75 31 9514 2679 64486508
Blood magnesium increased 98.85 13.75 31 9514 3200 64485987
Pleural fibrosis 91.97 13.75 31 9514 4019 64485168
Deafness neurosensory 88.88 13.75 34 9511 6340 64482847
Epigastric discomfort 79.71 13.75 32 9513 6779 64482408
Infective pulmonary exacerbation of cystic fibrosis 74.76 13.75 36 9509 11760 64477427
Cyst 62.28 13.75 32 9513 11995 64477192
Dry eye 60.44 13.75 43 9502 28976 64460211
Osteopenia 57.25 13.75 33 9512 15507 64473680
Skin lesion 47.59 13.75 41 9504 36441 64452746
Bone cyst 42.81 13.75 15 9530 2182 64487005
Blood potassium increased 37.59 13.75 31 9514 25949 64463238
Osteosclerosis 32.74 13.75 14 9531 3472 64485715
Deformity 27.62 13.75 15 9530 6282 64482905
Osteoarthritis 24.61 13.75 38 9507 63298 64425889
Osteochondritis 23.50 13.75 4 9541 24 64489163
Sleep disorder 23.44 13.75 36 9509 59673 64429514
Cystic fibrosis 23.34 13.75 11 9534 3423 64485764
Enterobacter infection 22.57 13.75 11 9534 3685 64485502
Granulomatous liver disease 22.50 13.75 8 9537 1214 64487973
Underdose 22.12 13.75 23 9522 25806 64463381
Exostosis 21.64 13.75 16 9529 11422 64477765
Gastrointestinal disorder 20.86 13.75 43 9502 89666 64399521
Treatment failure 20.45 13.75 50 9495 116766 64372421
Completed suicide 18.79 13.75 5 9540 224409 64264778
Bone hypertrophy 18.25 13.75 5 9540 321 64488866
Vitamin A decreased 18.08 13.75 3 9542 15 64489172
Prealbumin decreased 17.37 13.75 4 9541 126 64489061
Breast cancer 16.57 13.75 21 9524 29127 64460060
Hypervitaminosis A 16.45 13.75 3 9542 28 64489159
Hiatus hernia strangulated 16.23 13.75 4 9541 169 64489018
Blood creatinine increased 15.72 13.75 50 9495 135732 64353455
Oesophageal adenocarcinoma 14.03 13.75 5 9540 764 64488423
Hospitalisation 14.02 13.75 33 9512 75174 64414013

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D10AD02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Retinoids for topical use in acne
ATC R01AX02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01XA02 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0022788 Vitamin A
CHEBI has role CHEBI:24020 fat-soluble vitamins
CHEBI has role CHEBI:25212 metabolites
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175950 Vitamin A
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitamin A deficiency indication 72000004
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Prevention of dental caries indication 426482000
Mineral Deficiency Prevention indication
Vitamin Deficiency Prevention indication
Diaper rash off-label use 91487003
Abetalipoproteinemia off-label use 190787008 DOID:1386
Skin irritation off-label use 367466007
Peptic ulcer contraindication 13200003 DOID:750
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Gastroenteritis contraindication 25374005 DOID:2326
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication
Malabsorption States contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.62 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
11-cis retinol dehydrogenase Enzyme WOMBAT-PK
Retinol dehydrogenase 12 Enzyme WOMBAT-PK
Retinol dehydrogenase 13 Enzyme WOMBAT-PK
Retinol-binding protein 3 Surface antigen WOMBAT-PK
Retinol-binding protein 5 Cytosolic other WOMBAT-PK
Retinoid-binding protein 7 Cytosolic other WOMBAT-PK
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Retinol-binding protein 2 Cytosolic other WOMBAT-PK
Retinal dehydrogenase 2 Enzyme WOMBAT-PK
Retinal dehydrogenase 1 Enzyme WOMBAT-PK
Retinaldehyde-binding protein 1 Transporter WOMBAT-PK
Retinol-binding protein 1 Cytosolic other WOMBAT-PK
Amyloid beta A4 protein Unclassified IC50 6.75 CHEMBL
Nuclear receptor subfamily 2 group C member 2 Nuclear other AGONIST EC50 4.71 IUPHAR
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

IDSource
4021164 VUID
N0000148615 NUI
D06543 KEGG_DRUG
11103-57-4 SECONDARY_CAS_RN
4017648 VANDF
4021164 VANDF
4021715 VANDF
C0042839 UMLSCUI
CHEBI:50211 CHEBI
RTL PDB_CHEM_ID
CHEMBL986 ChEMBL_ID
CHEMBL1675 ChEMBL_ID
DB00162 DRUGBANK_ID
D014801 MESH_DESCRIPTOR_UI
445354 PUBCHEM_CID
4053 IUPHAR_LIGAND_ID
2243 INN_ID
G2SH0XKK91 UNII
11246 RXNORM
232172 MMSL
5678 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 330 ug ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 6000 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2700 [iU] ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1100 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 4000 [iU] ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 900 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1100 [iU] ORAL unapproved drug other 7 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Budpak Vitamin A and D HUMAN OTC DRUG LABEL 2 27293-036 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 11 50090-0356 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multivitamin with fluoride HUMAN PRESCRIPTION DRUG LABEL 11 50090-0435 TABLET, CHEWABLE 2500 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 50090-4475 TABLET, CHEWABLE 750 ug ORAL unapproved drug other 10 sections
Multi Vitamin and Mineralvitamin HUMAN OTC DRUG LABEL 11 51220-2001 TABLET, CHEWABLE 3.50 mg ORAL unapproved drug other 8 sections
Vitamin A and D HUMAN OTC DRUG LABEL 2 52000-026 CREAM 181.80 [iU] TOPICAL OTC monograph not final 11 sections
Kimchi Vitaminchewable multivitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 0.68 mg ORAL unapproved drug other 2 sections
Multi-Vitamin Fluoride Drops HUMAN PRESCRIPTION DRUG LABEL 10 52959-593 SOLUTION 1500 [iU] ORAL Unapproved drug other 11 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-163 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-164 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 58657-165 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
M-Natal Plus HUMAN PRESCRIPTION DRUG LABEL 14 58657-170 TABLET 4000 [iU] ORAL unapproved drug other 7 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-323 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections
Tri-Vite Drops with Fluoride HUMAN PRESCRIPTION DRUG LABEL 4 58657-324 SOLUTION 1500 [iU] ORAL unapproved drug other 9 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-107 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-108 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 9 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 12 59088-109 TABLET, CHEWABLE 750 ug ORAL unapproved drug other 10 sections
INATAL ADVANCE HUMAN PRESCRIPTION DRUG LABEL 16 63044-153 TABLET, COATED 2700 [iU] ORAL Unapproved drug other 11 sections
INATAL Ultra HUMAN PRESCRIPTION DRUG LABEL 16 63044-154 TABLET, COATED 2700 [iU] ORAL Unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 63629-1134 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 63629-1134 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections
Multivitamin with Fluoride HUMAN PRESCRIPTION DRUG LABEL 11 63629-1135 TABLET, CHEWABLE 2500 [iU] ORAL unapproved drug other 10 sections