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veralipride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| sulpiride derivatives and analogues | 2814 | 66644-81-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used in treatment of menopausal disorders; RN given refers to parent cpd
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK | 24 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6,PDK1,SIK2,TEK | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AL06 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Benzamides |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| MeSH PA | D014150 | Antipsychotic Agents |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
Related Drugs by ATC class:
N05AL Benzamides 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.94 | acidic |
| pKa2 | 8.28 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Enzyme | Ki | 6.39 | CHEMBL | |||||
| Carbonic anhydrase 1 | Enzyme | Ki | 5.57 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 5.94 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 7.51 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 7.62 | CHEMBL | |||||
| Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 6.16 | CHEMBL | |||||
| Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 7.33 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 6.01 | CHEMBL | |||||
| Carbonic anhydrase 6 | Enzyme | Ki | 7.19 | CHEMBL | |||||
| Carbonic anhydrase 14 | Enzyme | Ki | 6.80 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 7.04 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07311 | KEGG_DRUG |
| C0078168 | UMLSCUI |
| CHEBI:135600 | CHEBI |
| CHEMBL2105581 | ChEMBL_ID |
| DB13523 | DRUGBANK_ID |
| C027429 | MESH_SUPPLEMENTAL_RECORD_UI |
| 47979 | PUBCHEM_CID |
| 4781 | INN_ID |
| S7064109UD | UNII |
| 39468 | RXNORM |
| 005865 | NDDF |
| S7064109UD | INXIGHT DRUGS |
Pharmaceutical products:
None