levosulpiride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
sulpiride derivatives and analogues	1577	23672-07-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levopraid
levosulpiride
(-)-Sulpiride
L-Sulpiride
lesuride
levobren
levopride

Molecular weight: 341.43
Formula: C15H23N3O4S
CLOGP: 1.15
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 101.73
ALOGS: -2.80
ROTB: 6

Drug dosage:

Dose	Unit	Route
0.40	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebellar syndrome	101.17	48.72	18	422	3521	63485061
Galactorrhoea	85.44	48.72	16	424	4139	63484443
Serotonin syndrome	63.67	48.72	18	422	28664	63459918
Sopor	58.78	48.72	16	424	22148	63466434
Hyperprolactinaemia	55.26	48.72	11	429	3889	63484693
Hyperthermia	51.14	48.72	12	428	9144	63479438

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	95.25	42.11	27	699	32983	79710679
Cerebellar syndrome	88.26	42.11	18	708	5462	79738200
Galactorrhoea	83.06	42.11	16	710	3630	79740032
Drug interaction	54.30	42.11	38	688	415145	79328517
Serotonin syndrome	50.70	42.11	18	708	45009	79698653
Hyperprolactinaemia	50.23	42.11	11	715	4665	79738997
Disorganised speech	46.39	42.11	9	717	2108	79741554
Drug abuse	44.68	42.11	24	702	162667	79580995

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AL07	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Benzamides
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35476	neuroleptics
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:50919	antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.47	acidic
pKa2	12.66	acidic
pKa3	8.85	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.29		CHEMBL
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7.06		CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	5.68		CHEMBL
Myeloperoxidase	Enzyme	P05164	PERM_HUMAN		IC50	5.12		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	8.16		CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_BOVIN		Ki	4.30		CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		IC50	6.68		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		Ki	4.82		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	4.57		CHEMBL

External reference:

ID	Source
D07312	KEGG_DRUG
C0210380	UMLSCUI
CHEBI:64119	CHEBI
CHEMBL267044	ChEMBL_ID
DB16021	DRUGBANK_ID
C078143	MESH_SUPPLEMENTAL_RECORD_UI
688272	PUBCHEM_CID
958	IUPHAR_LIGAND_ID
6593	INN_ID
JTG7R315LK	UNII
018683	NDDF
1179629009	SNOMEDCT_US
702795007	SNOMEDCT_US

Pharmaceutical products:

None