levosulpiride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives 1577 23672-07-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levopraid
  • levosulpiride
  • (-)-Sulpiride
  • L-Sulpiride
  • lesuride
  • levobren
  • levopride
  • Molecular weight: 341.43
  • Formula: C15H23N3O4S
  • CLOGP: 1.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 101.73
  • ALOGS: -2.80
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AL07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Benzamides
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:35476 antipsychotic agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 acidic
pKa2 12.66 acidic
pKa3 8.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 7.29 CHEMBL
D(4) dopamine receptor GPCR Ki 5.68 CHEMBL
D(3) dopamine receptor GPCR Ki 7.06 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.30 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 4.82 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 4.57 CHEMBL
Dopamine receptor GPCR IC50 6.68 CHEMBL
D(2) dopamine receptor GPCR Ki 8.16 CHEMBL

External reference:

IDSource
D07312 KEGG_DRUG
702795007 SNOMEDCT_US
CHEMBL267044 ChEMBL_ID
JTG7R315LK UNII
6593 INN_ID
C078143 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:64119 CHEBI
958 IUPHAR_LIGAND_ID
688272 PUBCHEM_CID

Pharmaceutical products:

None