levosulpiride Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives 1577 23672-07-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levopraid
  • levosulpiride
  • (-)-Sulpiride
  • L-Sulpiride
  • lesuride
  • levobren
  • levopride
  • Molecular weight: 341.43
  • Formula: C15H23N3O4S
  • CLOGP: 1.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 101.73
  • ALOGS: -2.80
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 141.25 45.92 36 603 19792 46665631
Bradyphrenia 89.55 45.92 20 619 6210 46679213
Cerebellar syndrome 83.27 45.92 17 622 3448 46681975
Drug abuse 56.97 45.92 24 615 63384 46622039
Serotonin syndrome 50.49 45.92 17 622 24203 46661220

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 68.64 54.03 17 294 10974 29941193

Pharmacologic Action:

SourceCodeDescription
ATC N05AL07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Benzamides
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35476 grosser tranquilizer
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:50919 antiemetico

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 acidic
pKa2 12.66 acidic
pKa3 8.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 7.29 CHEMBL
D(4) dopamine receptor GPCR Ki 5.68 CHEMBL
D(3) dopamine receptor GPCR Ki 7.06 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.30 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 4.82 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 4.57 CHEMBL
Dopamine receptor GPCR IC50 6.68 CHEMBL
D(2) dopamine receptor GPCR Ki 8.16 CHEMBL

External reference:

IDSource
D07312 KEGG_DRUG
C0210380 UMLSCUI
CHEBI:64119 CHEBI
688272 PUBCHEM_CID
CHEMBL267044 ChEMBL_ID
DB16021 DRUGBANK_ID
C078143 MESH_SUPPLEMENTAL_RECORD_UI
958 IUPHAR_LIGAND_ID
6593 INN_ID
JTG7R315LK UNII
018683 NDDF
702795007 SNOMEDCT_US

Pharmaceutical products:

None