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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
levosulpiride 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
sulpiride derivatives and analogues
1577
23672-07-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
levopraid
levosulpiride
(-)-Sulpiride
L-Sulpiride
lesuride
levobren
levopride
Molecular weight: 341.43
Formula: C15H23N3O4S
CLOGP: 1.15
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 101.73
ALOGS: -2.80
ROTB: 6
Drug dosage:
Dose
Unit
Route
0.40
g
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebellar syndrome
101.17
48.72
18
422
3521
63485061
Galactorrhoea
85.44
48.72
16
424
4139
63484443
Serotonin syndrome
63.67
48.72
18
422
28664
63459918
Sopor
58.78
48.72
16
424
22148
63466434
Hyperprolactinaemia
55.26
48.72
11
429
3889
63484693
Hyperthermia
51.14
48.72
12
428
9144
63479438
Showing 1 to 6 of 6 entries
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Sopor
95.25
42.11
27
699
32983
79710679
Cerebellar syndrome
88.26
42.11
18
708
5462
79738200
Galactorrhoea
83.06
42.11
16
710
3630
79740032
Drug interaction
54.30
42.11
38
688
415145
79328517
Serotonin syndrome
50.70
42.11
18
708
45009
79698653
Hyperprolactinaemia
50.23
42.11
11
715
4665
79738997
Disorganised speech
46.39
42.11
9
717
2108
79741554
Drug abuse
44.68
42.11
24
702
162667
79580995
Showing 1 to 8 of 8 entries
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N05AL07
NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Benzamides
CHEBI has role
CHEBI:35469
antidepressants
CHEBI has role
CHEBI:35476
neuroleptics
CHEBI has role
CHEBI:48561
dopaminergic antagonists
CHEBI has role
CHEBI:50919
antiemetico
Showing 1 to 5 of 5 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.47
acidic
pKa2
12.66
acidic
pKa3
8.85
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
7.29
CHEMBL
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
7.06
CHEMBL
D(4) dopamine receptor
GPCR
P21917
DRD4_HUMAN
Ki
5.68
CHEMBL
Myeloperoxidase
Enzyme
P05164
PERM_HUMAN
IC50
5.12
CHEMBL
D(2) dopamine receptor
GPCR
DRD2_RAT
Ki
8.16
CHEMBL
D(1A) dopamine receptor
GPCR
DRD1_BOVIN
Ki
4.30
CHEMBL
Dopamine receptor
GPCR
DRD1_RAT
DRD3_RAT
DRD5_RAT
DRD4_RAT
DRD2_RAT
IC50
6.68
CHEMBL
Adrenergic receptor alpha-1
GPCR
ADA1B_RAT
ADA1D_RAT
ADA1A_RAT
Ki
4.82
CHEMBL
Serotonin 2 (5-HT2) receptor
GPCR
5HT2C_RAT
5HT2A_RAT
5HT2B_RAT
Ki
4.57
CHEMBL
Showing 1 to 9 of 9 entries
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External reference:
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ID
Source
018683
NDDF
1179629009
SNOMEDCT_US
6593
INN_ID
688272
PUBCHEM_CID
702795007
SNOMEDCT_US
958
IUPHAR_LIGAND_ID
C0210380
UMLSCUI
C078143
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:64119
CHEBI
CHEMBL267044
ChEMBL_ID
Showing 1 to 10 of 13 entries
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Pharmaceutical products:
None
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levosulpiride