valproic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • epival
  • divalproex sodium
  • depakote
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 100 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.084 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.278 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 43.451 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 4.831 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 39.400 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 30.680 % High 1
herg hERG pIC50 4.146 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.216 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.459 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 63.580 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 58
kinase-selectivity-class ACVR2B,AXL,GRK2 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.786 High 1
mh-clint Mouse hepatocyte intrinsic clearance 24.044 High 1
mppb Mouse plasma protein binding (% unbound) 84.960 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.238 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 40.610 % High 1
rh-clint Rat hepatocyte intrinsic clearance 11.041 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 96.330 % High 1
rppb Rat plasma protein binding (% unbound) 48.450 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 901.571 uM High 1

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2662.76 11.08 2098 143498 150531 90332320
Drug interaction 1902.16 11.08 2278 143318 274175 90208676
Hyperammonaemia 1428.17 11.08 495 145101 5980 90476871
Hyperammonaemic encephalopathy 1293.38 11.08 373 145223 2326 90480525
Status epilepticus 1225.47 11.08 601 144995 18273 90464578
Somnolence 1097.26 11.08 1508 144088 207576 90275275
Toxicity to various agents 1055.24 11.08 1756 143840 286090 90196761
Multiple-drug resistance 1044.86 11.08 413 145183 7363 90475488
Sopor 783.03 11.08 490 145106 24154 90458697
Foetal anticonvulsant syndrome 761.30 11.08 184 145412 493 90482358
Psychotic disorder 758.62 11.08 525 145071 30705 90452146
Drug level increased 729.65 11.08 490 145106 27272 90455579
Aggression 708.82 11.08 474 145122 26194 90456657
Generalised tonic-clonic seizure 668.33 11.08 508 145088 34395 90448456
Coma 645.21 11.08 685 144911 71947 90410904
Extrapyramidal disorder 625.81 11.08 366 145230 15937 90466914
Intentional overdose 615.02 11.08 756 144840 93078 90389773
Arthralgia 580.98 11.08 263 145333 778259 89704592
Schizoaffective disorder 573.44 11.08 239 145357 4908 90477943
Dysmorphism 572.73 11.08 198 145398 2370 90480481
Overdose 572.58 11.08 959 144637 156750 90326101
Tremor 571.60 11.08 943 144653 152230 90330621
Schizophrenia 567.67 11.08 333 145263 14581 90468270
Neuroleptic malignant syndrome 561.30 11.08 332 145264 14764 90468087
Petit mal epilepsy 554.99 11.08 231 145365 4727 90478124
Pain 543.26 11.08 483 145113 995858 89486993
Joint swelling 536.16 11.08 84 145512 503216 89979635
Electrocardiogram QT prolonged 532.66 11.08 619 144977 71837 90411014
Mania 513.07 11.08 306 145290 13818 90469033
Sedation 497.86 11.08 493 145103 47678 90435173
Pemphigus 497.77 11.08 5 145591 326859 90155992
Depressed level of consciousness 487.52 11.08 593 145003 72191 90410660
Infusion related reaction 483.45 11.08 53 145543 416727 90066124
Suicide attempt 481.96 11.08 600 144996 74799 90408052
Ammonia increased 480.83 11.08 209 145387 4777 90478074
Drug abuse 473.93 11.08 622 144974 81725 90401126
Arthropathy 473.16 11.08 29 145567 366213 90116638
Foetal exposure during pregnancy 472.51 11.08 455 145141 42520 90440331
Rheumatoid arthritis 470.62 11.08 28 145568 362586 90120265
Agitation 462.99 11.08 555 145041 66543 90416308
Hand deformity 449.09 11.08 5 145591 296357 90186494
Parkinsonism 440.05 11.08 277 145319 13788 90469063
Systemic lupus erythematosus 430.03 11.08 42 145554 361854 90120997
Glossodynia 429.52 11.08 21 145575 321758 90161093
Drug reaction with eosinophilia and systemic symptoms 425.99 11.08 429 145167 42329 90440522
Intentional self-injury 417.41 11.08 359 145237 28975 90453876
Epilepsy 399.19 11.08 572 145024 81634 90401217
Abnormal behaviour 395.34 11.08 312 145284 22316 90460535
Speech disorder developmental 393.14 11.08 117 145479 826 90482025
Abdominal discomfort 388.40 11.08 141 145455 477187 90005664
Swelling 385.58 11.08 99 145497 418959 90063892
Peripheral swelling 373.60 11.08 101 145495 413005 90069846
Granulocytopenia 370.50 11.08 189 145407 6252 90476599
Ataxia 357.27 11.08 268 145328 17774 90465077
Anticonvulsant drug level increased 356.98 11.08 126 145470 1610 90481241
Developmental delay 344.30 11.08 122 145474 1578 90481273
Drug resistance 341.53 11.08 326 145270 30123 90452728
Hypomania 336.85 11.08 198 145398 8699 90474152
Salivary hypersecretion 325.07 11.08 195 145401 8897 90473954
Drug ineffective for unapproved indication 321.00 11.08 462 145134 66182 90416669
Helicobacter infection 318.91 11.08 10 145586 226840 90256011
Folliculitis 311.57 11.08 3 145593 204350 90278501
Intellectual disability 309.58 11.08 105 145491 1181 90481670
Sinusitis 308.03 11.08 85 145511 343003 90139848
Treatment noncompliance 307.30 11.08 397 145199 51330 90431521
Discomfort 305.30 11.08 40 145556 274295 90208556
Myoclonic epilepsy 304.02 11.08 110 145486 1517 90481334
Nasopharyngitis 302.23 11.08 138 145458 406966 90075885
Pericarditis 301.57 11.08 39 145557 270112 90212739
Fatigue 300.18 11.08 909 144687 1153114 89329737
Cognitive disorder 298.16 11.08 456 145140 68951 90413900
Dyspnoea 294.98 11.08 609 144987 880346 89602505
Antipsychotic drug level increased 292.97 11.08 136 145460 3643 90479208
Wound 291.49 11.08 65 145531 302915 90179936
Altered state of consciousness 289.84 11.08 303 145293 31229 90451622
Irritability 284.55 11.08 318 145278 35344 90447507
Learning disorder 281.31 11.08 89 145507 789 90482062
Hallucination, auditory 278.47 11.08 220 145376 15755 90467096
Contraindicated product administered 269.81 11.08 89 145507 320050 90162801
Behaviour disorder 269.49 11.08 137 145459 4498 90478353
Encephalopathy 267.39 11.08 351 145245 46093 90436758
Hypernatraemia 266.71 11.08 174 145422 9213 90473638
Abortion spontaneous 265.10 11.08 378 145218 53678 90429173
Psoriatic arthropathy 262.10 11.08 30 145566 228305 90254546
Hypersensitivity 260.86 11.08 209 145387 454468 90028383
Disorientation 259.58 11.08 337 145259 43777 90439074
Partial seizures 255.13 11.08 154 145442 7106 90475745
Hypothermia 249.20 11.08 204 145392 15371 90467480
Drug level decreased 249.04 11.08 169 145427 9561 90473290
Stomatitis 246.61 11.08 68 145528 274630 90208221
Impaired healing 244.75 11.08 41 145555 234158 90248693
Autism spectrum disorder 243.78 11.08 88 145508 1205 90481646
Completed suicide 241.19 11.08 641 144955 144417 90338434
Respiratory depression 240.84 11.08 200 145396 15375 90467476
Muscle injury 240.60 11.08 10 145586 176644 90306207
Irritable bowel syndrome 238.74 11.08 27 145569 207421 90275430
Delusion 237.81 11.08 189 145407 13651 90469200
Stevens-Johnson syndrome 234.45 11.08 262 145334 29114 90453737
Anticonvulsant drug level decreased 233.29 11.08 87 145509 1313 90481538
Disturbance in attention 228.91 11.08 328 145268 46781 90436070
Pruritus 224.02 11.08 327 145269 541198 89941653
Mental disorder 215.78 11.08 263 145333 32055 90450796
Hypotonia 215.77 11.08 165 145431 11261 90471590
Osteoarthritis 214.23 11.08 30 145566 195700 90287151
Psychomotor hyperactivity 213.81 11.08 172 145424 12641 90470210
Fibromyalgia 213.56 11.08 37 145559 206232 90276619
Diarrhoea 212.06 11.08 786 144810 938404 89544447
Suicidal ideation 211.16 11.08 405 145191 73450 90409401
Drug ineffective 210.22 11.08 3249 142347 1381049 89101802
Psychomotor retardation 209.18 11.08 117 145479 4672 90478179
Catatonia 209.05 11.08 127 145469 5929 90476922
Anticonvulsant drug level above therapeutic 204.60 11.08 63 145533 506 90482345
Drug intolerance 203.59 11.08 252 145344 447339 90035512
Sudden unexplained death in epilepsy 198.20 11.08 57 145539 351 90482500
Electroencephalogram abnormal 198.01 11.08 107 145489 3989 90478862
Myoclonus 197.65 11.08 196 145400 18972 90463879
Pneumonia aspiration 197.37 11.08 284 145312 40656 90442195
Bipolar disorder 197.13 11.08 142 145454 8843 90474008
Psychomotor skills impaired 193.98 11.08 94 145502 2778 90480073
Therapeutic product effect decreased 192.39 11.08 103 145493 277468 90205383
Pain in extremity 191.24 11.08 267 145329 450262 90032589
Fanconi syndrome 185.89 11.08 81 145515 1862 90480989
Urticaria 182.70 11.08 141 145455 312593 90170258
Joint range of motion decreased 177.25 11.08 10 145586 135633 90347218
Intentional product use issue 176.27 11.08 64 145532 216828 90266023
Drug withdrawal convulsions 175.02 11.08 72 145524 1428 90481423
Hypoaesthesia 174.41 11.08 149 145447 314061 90168790
C-reactive protein abnormal 174.22 11.08 7 145589 127422 90355429
Muscle rigidity 171.55 11.08 159 145437 14150 90468701
Lower respiratory tract infection 170.81 11.08 95 145501 250564 90232287
Language disorder 170.72 11.08 84 145512 2568 90480283
Alopecia 170.55 11.08 336 145260 494735 89988116
Gastrointestinal disorder 169.62 11.08 101 145495 256586 90226265
Paradoxical drug reaction 169.02 11.08 109 145487 5657 90477194
Bursitis 168.12 11.08 11 145585 131643 90351208
Headache 167.10 11.08 766 144830 861980 89620871
Inflammation 166.35 11.08 41 145555 178551 90304300
Cerebral atrophy 166.16 11.08 107 145489 5539 90477312
Akathisia 165.72 11.08 140 145456 11019 90471832
Abdominal pain upper 164.51 11.08 175 145421 332499 90150352
Congenital nose malformation 164.18 11.08 47 145549 284 90482567
Dysarthria 163.44 11.08 305 145291 54177 90428674
Blister 163.40 11.08 104 145492 254894 90227957
Myocarditis 162.79 11.08 152 145444 13654 90469197
Learning disability 162.55 11.08 45 145551 236 90482615
Rhabdomyolysis 161.39 11.08 293 145303 50963 90431888
Product substitution issue 156.52 11.08 168 145428 17840 90465011
Nystagmus 155.78 11.08 113 145483 7114 90475737
Musculoskeletal stiffness 155.74 11.08 148 145448 296384 90186467
Blood creatine phosphokinase increased 155.27 11.08 230 145366 33793 90449058
Educational problem 150.67 11.08 50 145546 523 90482328
Bradyphrenia 150.53 11.08 113 145483 7499 90475352
Mobility decreased 149.03 11.08 111 145485 250623 90232228
Arthritis 149.01 11.08 42 145554 167273 90315578
Anticonvulsant drug level below therapeutic 148.79 11.08 52 145544 644 90482207
Thrombocytopenia 148.77 11.08 697 144899 208028 90274823
Infection 148.25 11.08 220 145376 361874 90120977
Speech disorder 147.89 11.08 264 145332 45321 90437530
Wrong patient received product 146.59 11.08 83 145513 3394 90479457
Seizure cluster 143.82 11.08 44 145552 345 90482506
Loss of consciousness 143.06 11.08 523 145073 139715 90343136
Carnitine deficiency 142.00 11.08 37 145559 147 90482704
Wound infection 141.66 11.08 7 145589 106395 90376456
Atonic seizures 140.71 11.08 52 145544 764 90482087
Medication overuse headache 138.49 11.08 61 145535 1440 90481411
Night sweats 137.95 11.08 21 145575 128745 90354106
Rash 137.28 11.08 736 144860 795364 89687487
Pulmonary fibrosis 137.21 11.08 9 145587 107494 90375357
Musculoskeletal pain 135.00 11.08 53 145543 171198 90311653
Ill-defined disorder 134.98 11.08 64 145532 184827 90298024
Asthma-chronic obstructive pulmonary disease overlap syndrome 132.35 11.08 88 145508 4811 90478040
Total lung capacity increased 130.38 11.08 88 145508 4933 90477918
Jaundice cholestatic 129.00 11.08 116 145480 9927 90472924
Hyperprolactinaemia 128.74 11.08 90 145506 5343 90477508
Persecutory delusion 128.33 11.08 74 145522 3134 90479717
Tonic convulsion 126.86 11.08 60 145536 1678 90481173
Meningomyelocele 125.95 11.08 45 145551 597 90482254
Talipes 125.71 11.08 59 145537 1621 90481230
Contusion 125.44 11.08 131 145465 251085 90231766
Toxic encephalopathy 124.81 11.08 107 145489 8592 90474259
Focal dyscognitive seizures 124.38 11.08 72 145524 3072 90479779
Leukopenia 124.05 11.08 400 145196 100310 90382541
Congenital foot malformation 123.12 11.08 36 145560 237 90482614
Blood prolactin increased 122.28 11.08 75 145521 3562 90479289
General physical health deterioration 122.20 11.08 241 145355 354874 90127977
Lethargy 121.50 11.08 295 145301 62844 90420007
Psychogenic seizure 121.33 11.08 61 145535 1955 90480896
Back pain 120.97 11.08 202 145394 316973 90165878
Congenital hand malformation 120.07 11.08 37 145559 298 90482553
Chest pain 119.68 11.08 206 145390 319439 90163412
Dyskinesia 119.04 11.08 212 145384 36322 90446529
Tardive dyskinesia 118.72 11.08 115 145481 10815 90472036
Injury 117.72 11.08 87 145509 197262 90285589
Grip strength decreased 117.41 11.08 8 145588 92568 90390283
Peripheral venous disease 116.81 11.08 4 145592 83917 90398934
Product residue present 115.73 11.08 77 145519 4214 90478637
Blood cholesterol increased 114.93 11.08 99 145497 207913 90274938
Mental status changes 114.40 11.08 234 145362 44445 90438406
Lip dry 113.97 11.08 14 145582 100941 90381910
Propofol infusion syndrome 112.62 11.08 51 145545 1288 90481563
Motor developmental delay 110.06 11.08 32 145564 206 90482645
Cough 110.00 11.08 271 145325 368691 90114160
Knee arthroplasty 109.07 11.08 6 145590 83176 90399675
Wheezing 108.15 11.08 134 145462 237946 90244905
Febrile neutropenia 107.85 11.08 60 145536 158289 90324562
Sciatica 107.53 11.08 17 145579 101365 90381486
Cardiac murmur 105.46 11.08 138 145458 18056 90464795
Cerebellar atrophy 105.38 11.08 42 145554 765 90482086
Asthma 105.14 11.08 141 145455 242019 90240832
Eosinophilic pleural effusion 103.60 11.08 28 145568 132 90482719
Injection site pain 101.76 11.08 78 145518 173621 90309230
Communication disorder 101.34 11.08 64 145532 3202 90479649
Enuresis 101.21 11.08 65 145531 3349 90479502
Toxic epidermal necrolysis 101.19 11.08 185 145411 32343 90450508
Hepatotoxicity 101.13 11.08 226 145370 45616 90437235
Drug hypersensitivity 100.98 11.08 393 145203 463216 90019635
Exposure during pregnancy 100.68 11.08 692 144904 237718 90245133
Hallucinations, mixed 100.27 11.08 80 145516 5809 90477042
Neovascularisation 100.10 11.08 50 145546 1580 90481271
Dystonia 99.71 11.08 129 145467 16690 90466161
Neutropenia 99.27 11.08 660 144936 224244 90258607
Hypertelorism 98.74 11.08 36 145560 508 90482343
Sinus rhythm 98.57 11.08 47 145549 1339 90481512
Pleurothotonus 97.17 11.08 46 145550 1289 90481562
Psychiatric symptom 96.96 11.08 85 145511 7033 90475818
Hepatic failure 96.94 11.08 204 145392 39524 90443327
Hallucination, visual 96.70 11.08 150 145446 22942 90459909
Paranoia 95.98 11.08 111 145485 12797 90470054
Hyponatraemia 95.86 11.08 447 145149 133091 90349760
Mental impairment 95.64 11.08 126 145470 16594 90466257
Abortion induced 94.79 11.08 106 145490 11782 90471069
Stupor 94.47 11.08 75 145521 5407 90477444
Liver injury 94.43 11.08 81 145515 170486 90312365
Metabolic acidosis 93.43 11.08 247 145349 55429 90427422
Oculogyric crisis 93.39 11.08 55 145541 2424 90480427
Restlessness 92.54 11.08 188 145408 35532 90447319
Low set ears 92.17 11.08 29 145567 252 90482599
Impulsive behaviour 91.54 11.08 48 145548 1682 90481169
Hepatic enzyme increased 91.14 11.08 287 145309 360449 90122402
Unresponsive to stimuli 90.99 11.08 194 145402 37927 90444924
Lung disorder 90.78 11.08 65 145531 149818 90333033
Hypotension 90.77 11.08 859 144737 324538 90158313
Anger 90.51 11.08 111 145485 13609 90469242
Hirsutism 89.21 11.08 47 145549 1663 90481188
Bipolar I disorder 88.58 11.08 50 145546 2032 90480819
Type 2 diabetes mellitus 88.57 11.08 118 145478 203126 90279725
Sarcoidosis 88.26 11.08 97 145499 10576 90472275
Hypertension 87.83 11.08 407 145189 457125 90025726
Muscle spasms 87.41 11.08 170 145426 251713 90231138
Infantile spasms 87.02 11.08 27 145569 223 90482628
Acute hepatic failure 86.83 11.08 141 145455 22420 90460431
Autoimmune disorder 85.75 11.08 11 145585 76733 90406118
Mitochondrial DNA mutation 85.70 11.08 31 145565 427 90482424
Arnold-Chiari malformation 85.60 11.08 35 145561 683 90482168
Hyperlactacidaemia 85.36 11.08 63 145533 4073 90478778
Hip arthroplasty 84.97 11.08 11 145585 76197 90406654
Serotonin syndrome 84.94 11.08 188 145408 37699 90445152
COVID-19 84.30 11.08 88 145508 168755 90314096
Amenorrhoea 84.15 11.08 99 145497 11623 90471228
Stillbirth 84.03 11.08 80 145516 7363 90475488
Hypertonia 83.47 11.08 68 145528 5087 90477764
Gingival hypertrophy 83.38 11.08 49 145547 2151 90480700
Metabolic encephalopathy 82.82 11.08 76 145520 6676 90476175
Nausea 82.56 11.08 1272 144324 1109044 89373807
Ileus paralytic 82.17 11.08 67 145529 5018 90477833
Spina bifida 81.96 11.08 36 145560 844 90482007
Poisoning 79.91 11.08 110 145486 15107 90467744
Hepatic function abnormal 79.34 11.08 207 145389 46081 90436770
Taste disorder 78.98 11.08 5 145591 61541 90421310
Intra-abdominal pressure increased 78.95 11.08 26 145570 265 90482586
Hyperthermia 78.74 11.08 90 145506 10245 90472606
Strabismus 78.18 11.08 49 145547 2419 90480432
Attention deficit hyperactivity disorder 78.07 11.08 60 145536 4124 90478727
Dyspraxia 77.16 11.08 25 145571 241 90482610
Neuropathy peripheral 75.86 11.08 65 145531 136905 90345946
Resting tremor 75.43 11.08 34 145562 849 90482002
Dry mouth 75.08 11.08 112 145484 183947 90298904
Nasal polyps 74.99 11.08 90 145506 10790 90472061
Red blood cell sedimentation rate increased 74.89 11.08 20 145576 82575 90400276
Brain oedema 74.30 11.08 114 145482 17271 90465580
Magnetic resonance imaging head abnormal 74.13 11.08 48 145548 2508 90480343
Psoriasis 73.77 11.08 77 145519 147677 90335174
Atrial septal defect 73.64 11.08 78 145518 8156 90474695
Herpes zoster 73.41 11.08 30 145566 94614 90388237
Hepatic cirrhosis 73.31 11.08 8 145588 63245 90419606
Malignant neoplasm progression 72.03 11.08 41 145555 106829 90376022
Astigmatism 71.33 11.08 38 145558 1376 90481475
Dementia 70.82 11.08 133 145463 23728 90459123
Ear malformation 70.67 11.08 24 145572 271 90482580
Encephalitis autoimmune 70.62 11.08 43 145553 2015 90480836
Cholelithiasis 70.57 11.08 215 145381 52291 90430560
Hypercholesterolaemia 70.48 11.08 37 145559 100855 90381996
Antipsychotic drug level decreased 70.04 11.08 26 145570 387 90482464
Obsessive-compulsive disorder 69.97 11.08 58 145538 4446 90478405
Hallucination 69.77 11.08 249 145347 65710 90417141
Grandiosity 69.58 11.08 24 145572 285 90482566
Microcephaly 69.27 11.08 37 145559 1347 90481504
Lower limb fracture 69.17 11.08 25 145571 84988 90397863
Drug level below therapeutic 68.52 11.08 64 145532 5750 90477101
Paraesthesia 68.35 11.08 192 145404 250134 90232717
Gait inability 67.99 11.08 81 145515 146375 90336476
Liver function test increased 67.28 11.08 26 145570 84829 90398022
Mood swings 67.27 11.08 120 145476 20582 90462269
Malaise 66.66 11.08 611 144985 585375 89897476
Fluid retention 66.59 11.08 29 145567 88062 90394789
Injection site erythema 66.09 11.08 38 145558 98464 90384387
Rhinorrhoea 65.31 11.08 30 145566 88286 90394565
Retinogram abnormal 65.24 11.08 20 145576 158 90482693
Neutrophil count increased 65.07 11.08 114 145482 19276 90463575
Dry skin 65.00 11.08 30 145566 88043 90394808
Suicidal behaviour 64.81 11.08 46 145550 2798 90480053
Hypokinesia 64.38 11.08 101 145495 15596 90467255
Change in seizure presentation 64.30 11.08 27 145569 565 90482286
Leukocytosis 64.16 11.08 149 145447 30841 90452010
Exostosis 63.45 11.08 6 145590 53128 90429723
Urinary incontinence 63.37 11.08 167 145429 37399 90445452
Apathy 62.84 11.08 83 145513 10957 90471894
Dyspepsia 62.63 11.08 141 145455 198019 90284832
Congenital eyelid malformation 62.55 11.08 12 145584 3 90482848
Injection site reaction 62.52 11.08 35 145561 92045 90390806
Oedema 62.10 11.08 144 145452 200151 90282700
Affect lability 61.66 11.08 107 145489 17956 90464895
White blood cell count increased 61.28 11.08 242 145354 66999 90415852
Rhinitis allergic 60.69 11.08 102 145494 16683 90466168
Nail disorder 60.21 11.08 11 145585 59056 90423795
Bradykinesia 60.17 11.08 64 145532 6724 90476127
Psychotic symptom 59.68 11.08 40 145556 2216 90480635
Neck pain 59.63 11.08 57 145539 113906 90368945
Necrosis ischaemic 59.57 11.08 30 145566 965 90481886
Disease recurrence 59.10 11.08 163 145433 37490 90445361
Withdrawal syndrome 58.88 11.08 119 145477 22405 90460446
Platelet count decreased 58.61 11.08 399 145197 136570 90346281
Joint stiffness 58.51 11.08 26 145570 78016 90404835
Dysgraphia 58.41 11.08 48 145548 3635 90479216
Depressed mood 57.81 11.08 195 145401 50027 90432824
Influenza 57.51 11.08 84 145512 139180 90343671
Nephrogenic diabetes insipidus 57.35 11.08 29 145567 941 90481910
Arachnodactyly 57.16 11.08 16 145580 88 90482763
Differential white blood cell count abnormal 57.12 11.08 29 145567 949 90481902
Balance disorder 56.95 11.08 307 145289 96773 90386078
Personal relationship issue 56.64 11.08 17 145579 124 90482727
Acidosis hyperchloraemic 56.25 11.08 28 145568 878 90481973
Oral mucosa erosion 56.00 11.08 33 145563 1456 90481395
Asthenia 55.82 11.08 568 145028 533183 89949668
Anaemia 55.81 11.08 335 145261 352467 90130384
Inappropriate antidiuretic hormone secretion 55.76 11.08 107 145489 19398 90463453
Dyslexia 55.43 11.08 24 145572 543 90482308
Psychiatric decompensation 55.15 11.08 36 145560 1907 90480944
Logorrhoea 55.07 11.08 41 145555 2686 90480165
Clinodactyly 55.05 11.08 17 145579 138 90482713
Nasal congestion 54.80 11.08 33 145563 83381 90399470
Neurodevelopmental disorder 54.46 11.08 19 145577 234 90482617
Bradypnoea 54.37 11.08 51 145545 4607 90478244
Drop attacks 53.87 11.08 25 145571 669 90482182
Lip disorder 53.39 11.08 33 145563 1589 90481262
Ventricular septal defect 53.36 11.08 54 145542 5353 90477498
Selective eating disorder 53.35 11.08 36 145560 2017 90480834
Affective disorder 52.95 11.08 64 145532 7729 90475122
Myopia 52.90 11.08 35 145561 1897 90480954
Road traffic accident 52.70 11.08 57 145539 107569 90375282
Galactorrhoea 52.33 11.08 50 145546 4622 90478229
Tonic clonic movements 51.58 11.08 33 145563 1689 90481162
Blood pressure systolic increased 51.27 11.08 15 145581 58330 90424521
Multiple congenital abnormalities 51.04 11.08 23 145573 574 90482277
Drug withdrawal syndrome 50.82 11.08 130 145466 28593 90454258
Subileus 50.61 11.08 44 145552 3600 90479251
Tachycardia 50.44 11.08 429 145167 157244 90325607
Plasma cell myeloma 50.42 11.08 4 145592 40824 90442027
Angiofibroma 50.38 11.08 15 145581 106 90482745
Delirium 50.13 11.08 313 145283 104046 90378805
Blood lactic acid increased 49.97 11.08 66 145530 8712 90474139
Productive cough 49.91 11.08 31 145565 77032 90405819
Product dose omission issue 49.88 11.08 270 145326 291417 90191434
Gene mutation 49.81 11.08 35 145561 2095 90480756
Pneumatosis 49.55 11.08 21 145575 450 90482401
Renal tubular acidosis 49.44 11.08 36 145560 2279 90480572
Respiratory acidosis 49.27 11.08 63 145533 8056 90474795
Lordosis 49.26 11.08 19 145577 316 90482535
Back injury 49.02 11.08 8 145588 46614 90436237
Macular degeneration 48.97 11.08 3 145593 37967 90444884
Mood altered 48.95 11.08 94 145502 17050 90465801
Craniosynostosis 48.95 11.08 16 145580 159 90482692
Refusal of treatment by patient 48.93 11.08 53 145543 5685 90477166
Cardiac failure congestive 48.62 11.08 52 145544 98642 90384209
Cerebral salt-wasting syndrome 48.32 11.08 17 145579 215 90482636
Off label use 48.03 11.08 2196 143400 1100056 89382795
Antipsychotic drug level above therapeutic 47.71 11.08 29 145567 1355 90481496
Withdrawal catatonia 47.57 11.08 16 145580 175 90482676
Mydriasis 47.47 11.08 86 145510 14926 90467925
Hypersexuality 46.89 11.08 22 145574 604 90482247
Epileptic encephalopathy 46.50 11.08 19 145577 370 90482481
Cardio-respiratory arrest 46.50 11.08 213 145383 62927 90419924
Euphoric mood 46.19 11.08 50 145546 5359 90477492
Delusion of grandeur 45.80 11.08 17 145579 253 90482598
Dyspnoea exertional 45.55 11.08 30 145566 72258 90410593
Partial seizures with secondary generalisation 45.53 11.08 20 145576 469 90482382
Pancreatitis acute 45.51 11.08 134 145462 31981 90450870
Reflexes abnormal 45.49 11.08 23 145573 746 90482105
Thermal burn 45.08 11.08 55 145541 6707 90476144
Drug level above therapeutic 44.95 11.08 51 145545 5758 90477093
Pectus excavatum 44.94 11.08 13 145583 82 90482769
Asterixis 44.87 11.08 30 145566 1655 90481196
Dysmetria 44.70 11.08 22 145574 673 90482178
Miosis 44.54 11.08 65 145531 9419 90473432
Posture abnormal 44.40 11.08 36 145560 2675 90480176
Blood gases abnormal 44.35 11.08 24 145572 897 90481954
Bronchitis 44.21 11.08 114 145482 152813 90330038
Sleep disorder due to a general medical condition 44.19 11.08 9 145587 44729 90438122
Upper respiratory tract infection 44.14 11.08 87 145509 128231 90354620
Drooling 44.13 11.08 45 145551 4501 90478350
Lennox-Gastaut syndrome 43.78 11.08 17 145579 288 90482563
Colitis ulcerative 43.74 11.08 21 145575 60245 90422606
Injection site pruritus 43.50 11.08 16 145580 53818 90429033
Feeling hot 43.21 11.08 37 145559 77971 90404880
Injection site bruising 43.20 11.08 15 145581 52292 90430559
Aphasia 43.05 11.08 159 145437 42653 90440198
Tooth malformation 42.69 11.08 9 145587 9 90482842
Cataract 42.68 11.08 32 145564 72060 90410791
Febrile convulsion 42.66 11.08 20 145576 548 90482303
Fat embolism syndrome 42.56 11.08 11 145585 42 90482809
Hyperchloraemia 42.37 11.08 23 145573 865 90481986
Psychotic behaviour 42.29 11.08 21 145575 655 90482196
Sluggishness 42.23 11.08 50 145546 5909 90476942
Camptodactyly congenital 42.21 11.08 9 145587 10 90482841
Drug eruption 42.10 11.08 139 145457 35268 90447583
Depressive symptom 41.92 11.08 47 145549 5238 90477613
Troponin increased 41.89 11.08 76 145520 13205 90469646
Screaming 41.75 11.08 40 145556 3710 90479141
Shock 41.67 11.08 121 145475 28657 90454194
Bone pain 41.45 11.08 24 145572 61959 90420892
Congenital oral malformation 41.44 11.08 15 145581 207 90482644
Speech sound disorder 41.31 11.08 9 145587 12 90482839
Sinus bradycardia 41.29 11.08 87 145509 16865 90465986
Polydipsia 41.29 11.08 42 145554 4189 90478662
Self-injurious ideation 41.14 11.08 37 145559 3166 90479685
Postictal paralysis 41.10 11.08 16 145580 273 90482578
Osteoporosis 41.06 11.08 57 145539 96474 90386377
Accidental overdose 41.05 11.08 119 145477 28154 90454697
Carnitine decreased 40.94 11.08 8 145588 3 90482848
Metabolic disorder 40.74 11.08 55 145541 7415 90475436
CSF oligoclonal band present 40.55 11.08 18 145578 433 90482418
Cardiac arrest 40.40 11.08 298 145298 104637 90378214
Rash maculo-papular 40.31 11.08 151 145445 40782 90442069
Drug dependence 40.26 11.08 121 145475 29206 90453645
Vascular encephalopathy 39.71 11.08 21 145575 749 90482102
Congenital scoliosis 39.53 11.08 11 145585 59 90482792
Impaired reasoning 39.52 11.08 13 145583 132 90482719
Hypermetropia 39.48 11.08 18 145578 462 90482389
Hypermobility syndrome 39.48 11.08 22 145574 872 90481979
Precocious puberty 39.47 11.08 16 145580 305 90482546
Blood pressure increased 39.22 11.08 173 145423 197044 90285807
Arrhythmia 39.09 11.08 153 145443 42179 90440672
Thrombosis 39.06 11.08 36 145560 73215 90409636
Weight gain poor 38.97 11.08 24 145572 1148 90481703
Cogwheel rigidity 38.91 11.08 30 145566 2072 90480779
Mutism 38.90 11.08 28 145568 1741 90481110
Sinus tachycardia 38.54 11.08 117 145479 28396 90454455
Myalgia 38.33 11.08 148 145448 174977 90307874
Dyscalculia 38.03 11.08 13 145583 150 90482701
Chest discomfort 37.84 11.08 106 145490 138259 90344592
Disease progression 37.83 11.08 127 145469 156488 90326363
Brain death 37.58 11.08 39 145557 3982 90478869
Eye movement disorder 37.46 11.08 48 145548 6150 90476701
Oropharyngeal oedema 37.36 11.08 16 145580 352 90482499
Prognathism 37.29 11.08 12 145584 113 90482738
Social avoidant behaviour 37.23 11.08 36 145560 3377 90479474
Stereotypy 37.19 11.08 17 145579 439 90482412
Clonus 37.09 11.08 46 145550 5704 90477147
Congenital joint malformation 37.01 11.08 8 145588 10 90482841
Hypotonia neonatal 36.98 11.08 25 145571 1405 90481446
Abdominal pain 36.97 11.08 432 145164 395289 90087562
Tic 36.97 11.08 28 145568 1883 90480968
Throat irritation 36.85 11.08 16 145580 48679 90434172
Glycosuria 36.79 11.08 25 145571 1417 90481434
Plagiocephaly 36.73 11.08 12 145584 119 90482732
Chorea 36.64 11.08 29 145567 2081 90480770
Automatism 36.56 11.08 11 145585 81 90482770
Adjustment disorder with mixed anxiety and depressed mood 36.38 11.08 12 145584 123 90482728
Injection site swelling 36.15 11.08 26 145570 59813 90423038
Lung neoplasm malignant 36.05 11.08 103 145493 24170 90458681
Syndactyly 35.80 11.08 18 145578 577 90482274
Staring 35.74 11.08 26 145570 1644 90481207
Antipsychotic drug level below therapeutic 35.67 11.08 15 145581 315 90482536
Congenital hair disorder 35.57 11.08 10 145586 56 90482795
Hyperglycinaemia 35.56 11.08 7 145589 3 90482848
Chills 35.43 11.08 102 145494 131879 90350972
Intentional product misuse 35.38 11.08 256 145340 89348 90393503
Bradycardia neonatal 35.37 11.08 22 145574 1071 90481780
Walking aid user 35.37 11.08 7 145589 35499 90447352
Brief psychotic disorder, with postpartum onset 35.32 11.08 9 145587 32 90482819
Illness 35.27 11.08 48 145548 81921 90400930
Rabbit syndrome 35.24 11.08 15 145581 325 90482526
Loss of personal independence in daily activities 35.23 11.08 107 145489 135998 90346853
Pancreatitis 35.15 11.08 212 145384 69614 90413237
Anaemia macrocytic 35.14 11.08 40 145556 4532 90478319
Disorganised speech 35.10 11.08 27 145569 1858 90480993
Clonic convulsion 34.83 11.08 20 145576 840 90482011
Ketosis-prone diabetes mellitus 34.72 11.08 8 145588 16 90482835
Respiratory arrest 34.58 11.08 125 145471 33186 90449665
Pleocytosis 34.43 11.08 21 145575 987 90481864
Haematochezia 34.22 11.08 38 145558 70875 90411976
Anticonvulsant drug level abnormal 34.10 11.08 9 145587 38 90482813
Rectal haemorrhage 34.06 11.08 50 145546 82694 90400157
High arched palate 34.05 11.08 11 145585 105 90482746
Cleft palate 34.01 11.08 23 145573 1293 90481558
Limbic encephalitis 33.88 11.08 14 145582 281 90482570
Conjunctival hyperaemia 33.77 11.08 33 145563 3136 90479715
Blepharospasm 33.61 11.08 24 145572 55421 90427430
Hypersomnia 33.58 11.08 93 145503 21438 90461413
Congenital central nervous system anomaly 33.48 11.08 16 145580 458 90482393
Weight decreased 33.48 11.08 420 145176 379490 90103361
Disinhibition 33.32 11.08 21 145575 1047 90481804
Hypothyroidism 33.20 11.08 171 145425 52956 90429895
Atrial fibrillation 33.20 11.08 107 145489 133504 90349347
Anaphylactic reaction 33.08 11.08 56 145540 87468 90395383
Sinus congestion 33.00 11.08 3 145593 27421 90455430
Choroidal coloboma 32.94 11.08 8 145588 22 90482829
Polycystic ovaries 32.94 11.08 43 145553 5611 90477240
Cyclothymic disorder 32.81 11.08 13 145583 233 90482618
Akinesia 32.62 11.08 25 145571 1711 90481140
Interstitial lung disease 32.61 11.08 45 145551 76360 90406491
Polydactyly 32.57 11.08 14 145582 311 90482540
Hypophosphataemic osteomalacia 32.56 11.08 13 145583 238 90482613
Heterophoria 32.54 11.08 9 145587 47 90482804
Reading disorder 32.44 11.08 21 145575 1097 90481754
Angiomyolipoma 32.31 11.08 13 145583 243 90482608
Flushing 32.19 11.08 58 145538 88433 90394418
Growth retardation 32.03 11.08 25 145571 1758 90481093
Hot flush 32 11.08 29 145567 59459 90423392
Hypoventilation 31.99 11.08 41 145555 5255 90477596
Ovarian granulosa-theca cell tumour 31.95 11.08 8 145588 26 90482825
Breast hyperplasia 31.92 11.08 14 145582 327 90482524
Macroglossia 31.80 11.08 19 145577 860 90481991
Death 31.73 11.08 529 145067 456022 90026829
Physical assault 31.66 11.08 19 145577 867 90481984
Device expulsion 31.64 11.08 13 145583 40873 90441978
Strabismus congenital 31.49 11.08 9 145587 54 90482797
Pain in jaw 31.49 11.08 19 145577 47966 90434885
Poor sucking reflex 31.37 11.08 15 145581 430 90482421
Weight increased 31.29 11.08 886 144710 417041 90065810
Cytokine release syndrome 31.27 11.08 4 145592 27969 90454882
Cerebral ventricle dilatation 31.22 11.08 20 145576 1026 90481825
Lupus-like syndrome 31.14 11.08 20 145576 48826 90434025
Liver disorder 30.91 11.08 96 145500 121173 90361678
Diplopia 30.87 11.08 109 145487 28605 90454246
Cystitis 30.85 11.08 37 145559 66681 90416170
Metabolic syndrome 30.84 11.08 25 145571 1857 90480994
Trichoglossia 30.81 11.08 15 145581 448 90482403
Negativism 30.81 11.08 15 145581 448 90482403
Haematocrit decreased 30.71 11.08 141 145455 41691 90441160
Increased appetite 30.56 11.08 62 145534 11703 90471148
Gait disturbance 30.55 11.08 588 145008 259908 90222943
Anuria 30.40 11.08 71 145525 14747 90468104
Procedural pain 30.39 11.08 8 145588 33352 90449499
Myelosuppression 30.19 11.08 25 145571 53566 90429285
Coordination abnormal 30.16 11.08 89 145507 21267 90461584
Choreoathetosis 30.12 11.08 16 145580 576 90482275
Verbal abuse 30.10 11.08 10 145586 105 90482746
Blood bilirubin increased 30.06 11.08 144 145452 43326 90439525
Bone marrow oedema syndrome 30.06 11.08 9 145587 65 90482786
Cerebellar syndrome 29.97 11.08 34 145562 3838 90479013
Adverse event 29.90 11.08 93 145503 117325 90365526
Coloboma 29.85 11.08 10 145586 108 90482743
Poor personal hygiene 29.75 11.08 14 145582 387 90482464
Pancreatitis necrotising 29.59 11.08 27 145569 2354 90480497
Poisoning deliberate 29.56 11.08 75 145521 16411 90466440
Gastrointestinal haemorrhage 29.50 11.08 63 145533 90185 90392666
Scoliosis 29.41 11.08 52 145544 8855 90473996
Hyperphagia 29.39 11.08 29 145567 2789 90480062
Congenital hypothyroidism 29.21 11.08 12 145584 237 90482614
Sexually inappropriate behaviour 29.20 11.08 10 145586 116 90482735
Ear disorder 29.17 11.08 37 145559 4693 90478158
Nasal disorder 29.11 11.08 31 145565 3261 90479590
Cross sensitivity reaction 29.05 11.08 29 145567 2828 90480023
Hyperreflexia 28.93 11.08 44 145552 6613 90476238
Congenital flat feet 28.89 11.08 8 145588 42 90482809
Lactate pyruvate ratio increased 28.83 11.08 9 145587 76 90482775
Agranulocytosis 28.74 11.08 122 145474 34880 90447971
Erythema 28.68 11.08 233 145363 229013 90253838
Skin ulcer 28.66 11.08 23 145573 50052 90432799
Neoplasm progression 28.66 11.08 18 145578 44468 90438383
Mitochondrial toxicity 28.42 11.08 16 145580 647 90482204
Thinking abnormal 28.33 11.08 60 145536 11672 90471179
Therapeutic product effective for unapproved indication 28.31 11.08 10 145586 128 90482723
Sleep disorder 28.23 11.08 194 145402 197836 90285015
Respiratory disorder neonatal 28.15 11.08 21 145575 1380 90481471
Oropharyngeal pain 28.09 11.08 93 145503 115094 90367757
Paraesthesia oral 28.07 11.08 8 145588 31651 90451200
Drug screen false positive 28.07 11.08 18 145578 925 90481926
Ulcer 27.90 11.08 9 145587 32873 90449978
Eosinophilia 27.88 11.08 105 145491 28428 90454423
Mucosal inflammation 27.67 11.08 31 145565 57594 90425257
Metastases to bone 27.67 11.08 4 145592 25501 90457350
Hereditary ataxia 27.67 11.08 7 145589 24 90482827
Ultrasound ovary abnormal 27.66 11.08 9 145587 88 90482763
Hyporesponsive to stimuli 27.60 11.08 22 145574 1595 90481256
Conductive deafness 27.43 11.08 10 145586 141 90482710
Epistaxis 27.34 11.08 60 145536 85065 90397786
Parkinsonian gait 27.33 11.08 15 145581 577 90482274
Gaze palsy 27.31 11.08 22 145574 1619 90481232
Executive dysfunction 27.29 11.08 12 145584 282 90482569
Muscular weakness 27.27 11.08 207 145389 206459 90276392
Bronchiectasis 26.85 11.08 88 145508 22242 90460609
Apraxia 26.85 11.08 25 145571 2237 90480614
Systemic inflammatory response syndrome 26.82 11.08 42 145554 6474 90476377
Diverticulitis 26.82 11.08 20 145576 45167 90437684
Emotional disorder 26.66 11.08 68 145528 14929 90467922
Generalised anxiety disorder 26.32 11.08 27 145569 2720 90480131
Circulatory collapse 26.31 11.08 94 145502 24810 90458041
Oral candidiasis 26.28 11.08 12 145584 35443 90447408
Urine amphetamine positive 26.23 11.08 8 145588 62 90482789
Autonomic nervous system imbalance 26.21 11.08 30 145566 3420 90479431
Bradycardia 26.20 11.08 227 145369 83620 90399231
Hydrocephalus 26.09 11.08 40 145556 6054 90476797
Postictal state 26.04 11.08 20 145576 1373 90481478
Illogical thinking 26.01 11.08 8 145588 64 90482787
Frequent bowel movements 25.87 11.08 32 145564 56903 90425948
Echolalia 25.86 11.08 12 145584 321 90482530
Mitochondrial cytopathy 25.81 11.08 11 145585 239 90482612
Vestibular migraine 25.73 11.08 11 145585 241 90482610
Dacryostenosis congenital 25.72 11.08 6 145590 13 90482838
Confusional state 25.72 11.08 807 144789 385398 90097453
Gastrointestinal sounds abnormal 25.62 11.08 34 145562 4509 90478342
Rash morbilliform 25.62 11.08 32 145564 3997 90478854
Respiratory failure 25.58 11.08 297 145299 118121 90364730
Transaminases increased 25.57 11.08 123 145473 37069 90445782
Food interaction 25.52 11.08 19 145577 1245 90481606
Localised infection 25.44 11.08 11 145585 33551 90449300
Diabetes mellitus 25.40 11.08 185 145411 64690 90418161
Megacolon 25.38 11.08 24 145572 2190 90480661
Basal cell carcinoma 25.22 11.08 11 145585 33378 90449473
Fungal infection 25.17 11.08 19 145577 42642 90440209
Rebound effect 25.03 11.08 50 145546 9334 90473517
Chronic obstructive pulmonary disease 24.72 11.08 203 145393 73626 90409225
Encephalitis 24.67 11.08 55 145541 11079 90471772
Ulcer haemorrhage 24.57 11.08 6 145590 26315 90456536
Erythema multiforme 24.39 11.08 58 145538 12188 90470663
Head injury 24.30 11.08 107 145489 31081 90451770
Influenza B virus test positive 24.17 11.08 11 145585 281 90482570
Judgement impaired 24.15 11.08 16 145580 869 90481982
Childhood asthma 24.08 11.08 8 145588 84 90482767
Knee deformity 24.02 11.08 20 145576 1542 90481309
Incontinence 23.96 11.08 61 145535 13374 90469477
Borderline personality disorder 23.88 11.08 17 145579 1039 90481812
Congenital cystic kidney disease 23.85 11.08 13 145583 493 90482358
Transient aphasia 23.69 11.08 7 145589 48 90482803
Pressure of speech 23.67 11.08 15 145581 755 90482096
Lip erosion 23.64 11.08 18 145578 1220 90481631
Laryngitis 23.62 11.08 28 145568 50725 90432126
Acquired macroglossia 23.61 11.08 10 145586 214 90482637
Dysphagia 23.54 11.08 280 145316 111998 90370853
Treatment failure 23.51 11.08 345 145251 303583 90179268
Nose deformity 23.39 11.08 10 145586 219 90482632
Retinitis pigmentosa 23.37 11.08 9 145587 149 90482702
Blood pressure fluctuation 23.25 11.08 30 145566 52383 90430468
Hypersomnia-bulimia syndrome 23.24 11.08 5 145591 6 90482845
Incoherent 23.21 11.08 34 145562 4943 90477908
Lipids abnormal 23.21 11.08 11 145585 309 90482542
Fanconi syndrome acquired 23.18 11.08 18 145578 1256 90481595
Palpitations 23.11 11.08 127 145469 136601 90346250
Heart disease congenital 23.08 11.08 20 145576 1629 90481222
Tachypnoea 23.00 11.08 81 145515 21228 90461623
Illiteracy 22.99 11.08 6 145590 24 90482827
Somatic symptom disorder 22.96 11.08 28 145568 3413 90479438
Prominent epicanthal folds 22.87 11.08 7 145589 55 90482796
Right ventricular hypertrophy 22.86 11.08 15 145581 802 90482049
Eosinophil count decreased 22.84 11.08 27 145569 3185 90479666
Brain stem microhaemorrhage 22.61 11.08 6 145590 26 90482825
Tachyphrenia 22.49 11.08 20 145576 1686 90481165
Drug monitoring procedure incorrectly performed 22.48 11.08 11 145585 332 90482519
Anotia 22.41 11.08 5 145591 8 90482843
Cleft uvula 22.41 11.08 5 145591 8 90482843
Rotavirus infection 22.36 11.08 12 145584 441 90482410
Heart rate decreased 22.35 11.08 32 145564 53473 90429378
Thyroxine free decreased 22.35 11.08 15 145581 833 90482018
Conversion disorder 22.22 11.08 22 145574 2124 90480727
Movement disorder 22.19 11.08 99 145497 28920 90453931
Ligament laxity 22.14 11.08 9 145587 173 90482678
Drug tolerance decreased 22.12 11.08 12 145584 32118 90450733
Sinus disorder 22.10 11.08 14 145582 34433 90448418
Developmental regression 22.08 11.08 6 145590 29 90482822
Nipple disorder 22.06 11.08 10 145586 253 90482598
Blood triglycerides increased 22.02 11.08 60 145536 13701 90469150
Mitochondrial enzyme deficiency 21.91 11.08 6 145590 30 90482821
Multiple organ dysfunction syndrome 21.87 11.08 186 145410 68150 90414701
Aspiration 21.78 11.08 65 145531 15628 90467223
Cerebellar microhaemorrhage 21.75 11.08 6 145590 31 90482820
Gaucher's disease 21.74 11.08 4 145592 0 90482851
Optic nerve hypoplasia 21.74 11.08 4 145592 0 90482851
Alpers disease 21.74 11.08 4 145592 0 90482851
Congenital astigmatism 21.74 11.08 4 145592 0 90482851
Gamma-glutamyltransferase increased 21.56 11.08 119 145477 37833 90445018
Deafness congenital 21.56 11.08 8 145588 119 90482732
Nephrocalcinosis 21.54 11.08 17 145579 1215 90481636
Palmar-plantar erythrodysaesthesia syndrome 21.54 11.08 9 145587 28014 90454837
Vomiting projectile 21.49 11.08 20 145576 1789 90481062
Hypervolaemia 21.45 11.08 13 145583 32744 90450107
Electrocardiogram T wave inversion 21.44 11.08 28 145568 3655 90479196
Neglect of personal appearance 21.43 11.08 8 145588 121 90482730
Coeliac disease 21.42 11.08 24 145572 44586 90438265
Attention-seeking behaviour 21.37 11.08 7 145589 70 90482781
Lymphangioleiomyomatosis 21.33 11.08 10 145586 274 90482577
Hypophagia 21.31 11.08 114 145482 35823 90447028
Perseveration 21.30 11.08 10 145586 275 90482576
Epileptic aura 21.29 11.08 7 145589 71 90482780
White blood cell count decreased 21.24 11.08 382 145214 166727 90316124
Cerebral disorder 21.12 11.08 35 145561 5659 90477192
Fine motor delay 21.10 11.08 9 145587 196 90482655
Metastases to liver 20.96 11.08 10 145586 28797 90454054
Intestinal ischaemia 20.95 11.08 45 145551 8838 90474013
Ventricular arrhythmia 20.85 11.08 30 145566 4291 90478560
Hypoplastic left heart syndrome 20.85 11.08 9 145587 202 90482649
Therapeutic product ineffective for unapproved indication 20.78 11.08 10 145586 291 90482560
Reduced facial expression 20.76 11.08 23 145573 2530 90480321
Crying 20.76 11.08 89 145507 25556 90457295
Neutrophilia 20.74 11.08 35 145561 5743 90477108
Hypoglycaemia 20.74 11.08 187 145409 69661 90413190
Respiratory distress 20.73 11.08 120 145476 38826 90444025
Deja vu 20.69 11.08 8 145588 134 90482717
Surgery 20.64 11.08 25 145571 44862 90437989
Hyperacusis 20.61 11.08 24 145572 2787 90480064
Megakaryocytes abnormal 20.59 11.08 6 145590 39 90482812
Micrognathia 20.47 11.08 10 145586 301 90482550
Creatinine renal clearance decreased 20.42 11.08 3 145593 18896 90463955
Dysphoria 20.41 11.08 36 145560 6118 90476733
Caesarean section 20.39 11.08 71 145525 18506 90464345
Sputum discoloured 20.35 11.08 4 145592 20387 90462464
Asphyxia 20.34 11.08 39 145557 7064 90475787
Joint dislocation 20.32 11.08 25 145571 44557 90438294
Congenital hepatomegaly 20.27 11.08 5 145591 15 90482836
Hepatomegaly 20.23 11.08 57 145539 13269 90469582
Intestinal pseudo-obstruction 20.23 11.08 16 145580 1147 90481704
Joint laxity 20.21 11.08 23 145573 2605 90480246
Cardiac steatosis 20.20 11.08 6 145590 42 90482809
Back disorder 20.07 11.08 8 145588 25623 90457228
Mixed anxiety and depressive disorder 20.07 11.08 11 145585 422 90482429
Pneumocystis jirovecii pneumonia 20.04 11.08 5 145591 21611 90461240
Lipids 20.03 11.08 5 145591 16 90482835
Congenital hearing disorder 20.03 11.08 5 145591 16 90482835
Wound complication 20.02 11.08 31 145565 4732 90478119
Numb chin syndrome 19.96 11.08 6 145590 44 90482807
Immunodeficiency 19.96 11.08 24 145572 43210 90439641
Ear pain 19.94 11.08 39 145557 57663 90425188
Blood alkaline phosphatase increased 19.92 11.08 139 145457 47940 90434911
Hepatic adenoma 19.92 11.08 11 145585 428 90482423
Inhibitory drug interaction 19.92 11.08 25 145571 3138 90479713
Acidosis 19.85 11.08 55 145541 12681 90470170
Injection site rash 19.84 11.08 7 145589 24166 90458685
Inappropriate affect 19.79 11.08 15 145581 1010 90481841
Hiatus hernia 19.72 11.08 8 145588 25353 90457498
Laboratory test abnormal 19.57 11.08 23 145573 41831 90441020
Amino acid level increased 19.51 11.08 11 145585 446 90482405
Intelligence test abnormal 19.51 11.08 4 145592 3 90482848
School refusal 19.51 11.08 4 145592 3 90482848
Blood insulin increased 19.48 11.08 8 145588 158 90482693
Pulmonary mass 19.44 11.08 11 145585 28761 90454090
Sneezing 19.36 11.08 12 145584 29857 90452994
VIth nerve paralysis 19.26 11.08 14 145582 884 90481967
Mitochondrial encephalomyopathy 19.25 11.08 7 145589 98 90482753
Acute generalised exanthematous pustulosis 19.25 11.08 57 145539 13646 90469205
Flight of ideas 19.22 11.08 11 145585 459 90482392
Urine sodium increased 19.18 11.08 7 145589 99 90482752
Vaginal discharge 19.05 11.08 4 145592 19460 90463391
Otitis media 19.04 11.08 34 145562 5836 90477015
Microphthalmos 19.02 11.08 8 145588 168 90482683
Finger deformity 18.96 11.08 15 145581 32882 90449969
Female genital tract fistula 18.93 11.08 3 145593 17865 90464986
Self-destructive behaviour 18.78 11.08 11 145585 480 90482371
Benign congenital hypotonia 18.69 11.08 6 145590 56 90482795
Right ventricular failure 18.68 11.08 4 145592 19201 90463650
Dysgeusia 18.62 11.08 35 145561 52525 90430326
Social (pragmatic) communication disorder 18.60 11.08 5 145591 23 90482828
Haemodynamic instability 18.60 11.08 51 145545 11688 90471163
Decreased appetite 18.47 11.08 462 145134 376078 90106773
Accidental poisoning 18.42 11.08 14 145582 946 90481905
Bronchiolitis 18.42 11.08 25 145571 3387 90479464
Opisthotonus 18.40 11.08 10 145586 377 90482474
Full blood count abnormal 18.34 11.08 19 145577 36578 90446273
Coagulopathy 18.22 11.08 80 145516 23209 90459642
Blood urea decreased 18.21 11.08 22 145574 2656 90480195
Maternal drugs affecting foetus 18.20 11.08 31 145565 5124 90477727
Pulmonary hypertension 18.19 11.08 25 145571 42498 90440353
Urine calcium/creatinine ratio increased 18.17 11.08 7 145589 116 90482735
Teratogenicity 18.09 11.08 9 145587 282 90482569
Premature baby 18.02 11.08 84 145512 24993 90457858
Aspartate aminotransferase decreased 18.00 11.08 14 145582 979 90481872
Product administration error 17.89 11.08 87 145509 26336 90456515
Pneumonitis 17.88 11.08 27 145569 44143 90438708
Eye pain 17.88 11.08 27 145569 44141 90438710
Central nervous system lesion 17.86 11.08 50 145546 11596 90471255
Choking 17.81 11.08 51 145545 11982 90470869
Anticholinergic syndrome 17.78 11.08 22 145574 2721 90480130
Pustular psoriasis 17.78 11.08 4 145592 18552 90464299
Osteonecrosis of jaw 17.74 11.08 22 145574 39081 90443770
Incorrect route of product administration 17.69 11.08 34 145562 50592 90432259
Rash pruritic 17.65 11.08 70 145526 82144 90400707
Maternal exposure timing unspecified 17.64 11.08 7 145589 22476 90460375
Maternal exposure during breast feeding 17.63 11.08 34 145562 6186 90476665
Device issue 17.62 11.08 13 145583 29524 90453327
Electrocardiogram QRS complex shortened 17.59 11.08 11 145585 541 90482310
Drug level changed 17.52 11.08 8 145588 206 90482645
Mucosal erosion 17.43 11.08 18 145578 1827 90481024
Herpes oesophagitis 17.42 11.08 8 145588 209 90482642
Musculoskeletal discomfort 17.37 11.08 6 145590 20985 90461866
Gender dysphoria 17.36 11.08 4 145592 8 90482843
Rebound psychosis 17.21 11.08 8 145588 215 90482636
Bipolar II disorder 17.20 11.08 10 145586 430 90482421
Monocyte count decreased 17.15 11.08 21 145575 2570 90480281
Electrocardiogram J wave abnormal 17.04 11.08 4 145592 9 90482842
Bladder sphincter atony 17.04 11.08 8 145588 220 90482631
C-reactive protein increased 16.92 11.08 198 145398 181191 90301660
Nodule 16.91 11.08 11 145585 26675 90456176
Drug tolerance 16.89 11.08 4 145592 17912 90464939
Grunting 16.87 11.08 8 145588 225 90482626
Adrenal insufficiency 16.80 11.08 14 145582 29907 90452944
Brachydactyly 16.77 11.08 8 145588 228 90482623
Urinary retention 16.76 11.08 111 145485 37633 90445218
Cardiac failure 16.75 11.08 105 145491 109391 90373460
Alanine aminotransferase increased 16.66 11.08 275 145321 118063 90364788
Developmental coordination disorder 16.60 11.08 5 145591 37 90482814
Electrocardiogram abnormal 16.58 11.08 45 145551 10253 90472598
Saccadic eye movement 16.56 11.08 6 145590 83 90482768
Cerebral palsy 16.55 11.08 8 145588 235 90482616
Product administered to patient of inappropriate age 16.45 11.08 28 145568 4625 90478226
Consciousness fluctuating 16.42 11.08 13 145583 933 90481918
Urine output increased 16.31 11.08 17 145579 1745 90481106
Diabetic encephalopathy 16.31 11.08 3 145593 0 90482851
Rhinotracheitis 16.31 11.08 3 145593 0 90482851
Anomaly of orbit, congenital 16.31 11.08 3 145593 0 90482851
Cognitive linguistic deficit 16.31 11.08 3 145593 0 90482851
Megakaryocytes 16.31 11.08 3 145593 0 90482851
Congenital cutis laxa 16.31 11.08 3 145593 0 90482851
Carnitine palmitoyltransferase deficiency 16.31 11.08 3 145593 0 90482851
Retinal anomaly congenital 16.31 11.08 3 145593 0 90482851
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 16.31 11.08 3 145593 0 90482851
Tibial torsion 16.31 11.08 3 145593 0 90482851
Soliloquy 16.31 11.08 9 145587 350 90482501
Transfusion 16.30 11.08 4 145592 17484 90465367
Tooth infection 16.29 11.08 6 145590 20164 90462687
Postural tremor 16.28 11.08 10 145586 476 90482375
Cholestasis 16.27 11.08 107 145489 36192 90446659
Epileptic psychosis 16.26 11.08 5 145591 40 90482811
Cortical dysplasia 16.26 11.08 5 145591 40 90482811
Coma scale abnormal 16.25 11.08 31 145565 5595 90477256
False positive investigation result 16.19 11.08 12 145584 781 90482070
Homicidal ideation 16.16 11.08 17 145579 1763 90481088
Oral herpes 16.13 11.08 18 145578 33506 90449345
Idiosyncratic drug reaction 16.12 11.08 13 145583 958 90481893
Wrong product administered 16.02 11.08 37 145559 7628 90475223
Hostility 15.99 11.08 19 145577 2254 90480597
Prothrombin time shortened 15.96 11.08 19 145577 2259 90480592
Tooth development disorder 15.94 11.08 5 145591 43 90482808
Vertigo 15.93 11.08 177 145419 69634 90413217
Faecal vomiting 15.91 11.08 12 145584 802 90482049
Abortion 15.89 11.08 21 145575 2774 90480077
Product use in unapproved indication 15.87 11.08 676 144920 335560 90147291
Ammonia abnormal 15.87 11.08 8 145588 258 90482593
Monocytosis 15.86 11.08 13 145583 981 90481870
Glassy eyes 15.82 11.08 6 145590 95 90482756
Radiculopathy 15.82 11.08 5 145591 18500 90464351
International normalised ratio increased 15.78 11.08 130 145466 47186 90435665
Prescribed overdose 15.78 11.08 92 145504 97533 90385318
Hyperventilation 15.78 11.08 34 145562 6694 90476157
Motor dysfunction 15.77 11.08 67 145529 19163 90463688
Histiocytic necrotising lymphadenitis 15.74 11.08 5 145591 45 90482806
Coma hepatic 15.70 11.08 11 145585 655 90482196
Joint effusion 15.69 11.08 6 145590 19704 90463147
Candida infection 15.62 11.08 19 145577 34038 90448813
Polyarthritis 15.61 11.08 5 145591 18345 90464506
Pericardial effusion 15.56 11.08 107 145489 36726 90446125
Congenital nipple anomaly 15.53 11.08 4 145592 15 90482836
Drug level fluctuating 15.50 11.08 10 145586 519 90482332
Gross motor delay 15.49 11.08 7 145589 176 90482675
Extensor plantar response 15.47 11.08 15 145581 1412 90481439
Decreased activity 15.46 11.08 38 145558 8154 90474697
Product selection error 15.45 11.08 8 145588 273 90482578
Hypoproteinaemia 15.44 11.08 22 145574 3120 90479731
Croup infectious 15.40 11.08 11 145585 676 90482175
Dry eye 15.38 11.08 45 145551 57886 90424965
Ebstein's anomaly 15.33 11.08 4 145592 16 90482835
Rib fracture 15.31 11.08 12 145584 26423 90456428
Pulmonary valve stenosis congenital 15.30 11.08 7 145589 181 90482670
Hepatocellular injury 15.26 11.08 89 145507 28869 90453982
Face oedema 15.23 11.08 76 145520 23242 90459609
Proctitis 15.21 11.08 3 145593 15256 90467595
Gastrostomy 15.19 11.08 12 145584 859 90481992
Hyperammonaemic crisis 15.18 11.08 5 145591 51 90482800
Adenoidal hypertrophy 15.17 11.08 6 145590 107 90482744
Neutrophil Pelger-Huet anomaly present 15.17 11.08 6 145590 107 90482744
Flatulence 15.14 11.08 27 145569 41340 90441511
Social problem 15.11 11.08 14 145582 1245 90481606
Amniocentesis abnormal 15.07 11.08 6 145590 109 90482742
Intestinal strangulation 15.07 11.08 6 145590 109 90482742
Diabetes insipidus 15.06 11.08 22 145574 3190 90479661
Multiple allergies 15.05 11.08 3 145593 15143 90467708
Head titubation 15.02 11.08 14 145582 1254 90481597
Pulmonary arterial hypertension 15.02 11.08 12 145584 26175 90456676
Flank pain 15.01 11.08 66 145530 19156 90463695
Blood citric acid increased 15.01 11.08 5 145591 53 90482798
Schizoaffective disorder bipolar type 14.99 11.08 7 145589 190 90482661
Sudden death 14.96 11.08 45 145551 10864 90471987
Pancytopenia 14.96 11.08 274 145322 119989 90362862
Mental disability 14.86 11.08 7 145589 194 90482657
Haemoptysis 14.85 11.08 19 145577 33301 90449550
Hepatic steatosis 14.83 11.08 106 145490 36839 90446012
Tympanic membrane disorder 14.82 11.08 7 145589 195 90482656
Cardiomegaly 14.80 11.08 65 145531 18860 90463991
Juvenile myoclonic epilepsy 14.78 11.08 4 145592 19 90482832
Plasmodium falciparum infection 14.76 11.08 5 145591 56 90482795
Slow response to stimuli 14.75 11.08 13 145583 1083 90481768
Therapy interrupted 14.75 11.08 37 145559 50071 90432780
Simple partial seizures 14.73 11.08 11 145585 724 90482127
Transferrin saturation decreased 14.71 11.08 12 145584 899 90481952
Blood bicarbonate increased 14.71 11.08 12 145584 899 90481952
Limb discomfort 14.70 11.08 24 145572 38036 90444815
Pharyngeal disorder 14.65 11.08 19 145577 2464 90480387
Fine motor skill dysfunction 14.60 11.08 29 145567 5390 90477461
Alkalosis 14.60 11.08 10 145586 574 90482277
Tubo-ovarian abscess 14.53 11.08 9 145587 435 90482416
Device difficult to use 14.52 11.08 5 145591 17520 90465331
Therapy partial responder 14.51 11.08 72 145524 21971 90460880
Delusional disorder, unspecified type 14.49 11.08 9 145587 437 90482414
Hypoglycaemia neonatal 14.49 11.08 13 145583 1109 90481742
Bundle branch block right 14.48 11.08 29 145567 5424 90477427
Pancreatic injury 14.45 11.08 5 145591 60 90482791
Cell death 14.44 11.08 21 145575 3034 90479817
Blindness cortical 14.43 11.08 10 145586 585 90482266
Neoplasm malignant 14.41 11.08 20 145576 33860 90448991
Laryngeal stenosis 14.38 11.08 14 145582 1325 90481526
Coma acidotic 14.36 11.08 6 145590 124 90482727
Regressive behaviour 14.32 11.08 7 145589 211 90482640
Acute psychosis 14.32 11.08 21 145575 3057 90479794
Procalcitonin increased 14.31 11.08 15 145581 1549 90481302
Alcohol abuse 14.31 11.08 17 145579 2016 90480835
Quadriparesis 14.26 11.08 19 145577 2530 90480321
Niemann-Pick disease 14.23 11.08 3 145593 3 90482848
Blood pyruvic acid increased 14.23 11.08 3 145593 3 90482848
Congenital pulmonary artery anomaly 14.23 11.08 3 145593 3 90482848
Paroxysmal perceptual alteration 14.23 11.08 5 145591 63 90482788
Full blood count decreased 14.22 11.08 16 145580 29673 90453178
Oral pain 14.20 11.08 19 145577 32664 90450187
Convulsive threshold lowered 14.13 11.08 9 145587 457 90482394
Dysphonia 14.00 11.08 53 145543 63031 90419820
Bromoderma 14.00 11.08 4 145592 24 90482827
Respiratory tract congestion 14.00 11.08 14 145582 27396 90455455
Impulse-control disorder 13.93 11.08 12 145584 970 90481881
Myositis 13.91 11.08 11 145585 24117 90458734
Monocyte count increased 13.90 11.08 39 145557 9058 90473793
Congenital laryngeal stridor 13.88 11.08 5 145591 68 90482783
Injection site haemorrhage 13.85 11.08 15 145581 28303 90454548
Lymphocyte count increased 13.80 11.08 24 145572 4035 90478816
Blood sodium increased 13.79 11.08 21 145575 3161 90479690
Benign rolandic epilepsy 13.77 11.08 3 145593 4 90482847
Disability 13.69 11.08 28 145568 40717 90442134
Brain injury 13.66 11.08 35 145561 7703 90475148
Severe myoclonic epilepsy of infancy 13.62 11.08 5 145591 72 90482779
Hip fracture 13.60 11.08 20 145576 33057 90449794
Hand-eye coordination impaired 13.59 11.08 4 145592 27 90482824
Aura 13.58 11.08 13 145583 1204 90481647
Activated partial thromboplastin time abnormal 13.53 11.08 6 145590 144 90482707
Adverse drug reaction 13.51 11.08 121 145475 116580 90366271
Colitis 13.51 11.08 62 145534 69880 90412971
Metabolic alkalosis 13.41 11.08 22 145574 3527 90479324
Breast cancer 13.39 11.08 43 145553 53718 90429133
Encapsulating peritoneal sclerosis 13.37 11.08 8 145588 363 90482488
Faecaloma 13.35 11.08 42 145554 10389 90472462
Torsade de pointes 13.31 11.08 54 145542 15128 90467723
Product use issue 13.30 11.08 416 145180 329503 90153348
Skin haemorrhage 13.30 11.08 9 145587 21371 90461480
Tendonitis 13.29 11.08 9 145587 21363 90461488
Post-traumatic stress disorder 13.23 11.08 32 145564 6796 90476055
Unmasking of previously unidentified disease 13.23 11.08 14 145582 1462 90481389
Binocular eye movement disorder 13.23 11.08 4 145592 30 90482821
Left ventricular hypertrophy 13.22 11.08 30 145566 6114 90476737
Manic symptom 13.20 11.08 5 145591 79 90482772
Alcohol use 13.16 11.08 15 145581 1702 90481149
Muscle twitching 13.16 11.08 75 145521 24127 90458724
Hemianopia homonymous 13.15 11.08 11 145585 854 90481997
Breech presentation 13.14 11.08 13 145583 1254 90481597
Abnormal sleep-related event 13.08 11.08 11 145585 860 90481991
Enlarged foetal cisterna magna 13.02 11.08 3 145593 6 90482845
Rasmussen encephalitis 13.02 11.08 3 145593 6 90482845
Congenital inguinal hernia 13.02 11.08 3 145593 6 90482845
Status migrainosus 13.02 11.08 6 145590 158 90482693
High-pitched crying 13.00 11.08 4 145592 32 90482819
Muscle spasticity 12.98 11.08 23 145573 35299 90447552
Gastrointestinal hypomotility 12.82 11.08 13 145583 1292 90481559
Ascites 12.73 11.08 37 145559 47703 90435148
Joint hyperextension 12.73 11.08 8 145588 397 90482454
Therapeutic response changed 12.72 11.08 13 145583 1304 90481547
Tooth hypoplasia 12.70 11.08 5 145591 88 90482763
Infusion site pain 12.69 11.08 8 145588 19730 90463121
Rubber sensitivity 12.68 11.08 19 145577 2818 90480033
Unwanted awareness during anaesthesia 12.64 11.08 8 145588 402 90482449
Hypercapnia 12.63 11.08 31 145565 6646 90476205
Aspartate aminotransferase increased 12.62 11.08 234 145362 102703 90380148
Anomaly of external ear congenital 12.61 11.08 6 145590 170 90482681
Renal hypoplasia 12.60 11.08 5 145591 90 90482761
Encephalomalacia 12.58 11.08 9 145587 554 90482297
Vagal nerve stimulator implantation 12.49 11.08 4 145592 37 90482814
Congenital tracheomalacia 12.49 11.08 4 145592 37 90482814
Folate deficiency 12.48 11.08 20 145576 3145 90479706
Lactic acidosis 12.47 11.08 130 145466 50333 90432518
Nikolsky's sign 12.45 11.08 5 145591 93 90482758
Bicytopenia 12.43 11.08 22 145574 3749 90479102
Acute myeloid leukaemia 12.42 11.08 9 145587 20631 90462220
Neurodegenerative disorder 12.42 11.08 8 145588 414 90482437
Electrocardiogram J wave 12.42 11.08 3 145593 8 90482843
Developmental hip dysplasia 12.41 11.08 14 145582 1571 90481280
Persistent left superior vena cava 12.40 11.08 4 145592 38 90482813
Microstomia 12.40 11.08 4 145592 38 90482813
Uveitis 12.39 11.08 5 145591 15898 90466953
Kidney infection 12.38 11.08 14 145582 25902 90456949
Continuous haemodiafiltration 12.32 11.08 11 145585 932 90481919
Feeling drunk 12.27 11.08 25 145571 4733 90478118
Wrong drug 12.26 11.08 7 145589 291 90482560
Drug-disease interaction 12.25 11.08 11 145585 939 90481912
Ankylosing spondylitis 12.25 11.08 3 145593 13130 90469721
Palatal disorder 12.24 11.08 7 145589 292 90482559
Respiratory disorder 12.20 11.08 58 145538 64758 90418093
Neonatal disorder 12.18 11.08 9 145587 583 90482268
Pharyngeal erythema 12.18 11.08 15 145581 1847 90481004
Lipid metabolism disorder 12.18 11.08 6 145590 184 90482667
Central-alveolar hypoventilation 12.16 11.08 3 145593 9 90482842
Congenital nail disorder 12.16 11.08 5 145591 99 90482752
Fear-related avoidance of activities 12.15 11.08 6 145590 185 90482666
Menstrual disorder 12.15 11.08 29 145567 6109 90476742
Congenital eye disorder 12.13 11.08 4 145592 41 90482810
Blood bilirubin decreased 12.11 11.08 11 145585 954 90481897
Clostridium difficile infection 12.10 11.08 25 145571 36220 90446631
Limb injury 12.05 11.08 20 145576 31488 90451363
Gout 12.04 11.08 6 145590 16853 90465998
Congenital genitourinary abnormality 12.04 11.08 4 145592 42 90482809
Device dislocation 12.03 11.08 20 145576 31462 90451389
Electrocardiogram T wave abnormal 12.01 11.08 18 145578 2670 90480181
Intention tremor 11.97 11.08 8 145588 441 90482410
Thought blocking 11.94 11.08 6 145590 192 90482659
Congenital neurological disorder 11.92 11.08 3 145593 10 90482841
Gangrene 11.89 11.08 3 145593 12873 90469978
Foetal death 11.79 11.08 65 145531 20658 90462193
Amblyopia 11.75 11.08 7 145589 315 90482536
Depression 11.73 11.08 593 145003 300008 90182843
Reproductive tract disorder 11.72 11.08 6 145590 200 90482651
Congenital oesophageal anomaly 11.70 11.08 3 145593 11 90482840
Skin disorder 11.68 11.08 26 145570 36680 90446171
Poverty of speech 11.63 11.08 7 145589 321 90482530
Food refusal 11.62 11.08 9 145587 626 90482225
Nightmare 11.60 11.08 67 145529 21658 90461193
Hyperaldosteronism 11.59 11.08 7 145589 323 90482528
Blood test abnormal 11.52 11.08 10 145586 20942 90461909
Congenital anomaly 11.51 11.08 29 145567 6318 90476533
Polyhydramnios 11.50 11.08 17 145579 2491 90480360
Malignant melanoma 11.48 11.08 3 145593 12573 90470278
Toxic skin eruption 11.45 11.08 53 145543 15721 90467130
MELAS syndrome 11.45 11.08 6 145590 210 90482641
Syringomyelia 11.42 11.08 6 145590 211 90482640
Neonatal respiratory distress syndrome 11.42 11.08 19 145577 3082 90479769
Deformity thorax 11.41 11.08 4 145592 50 90482801
Oppositional defiant disorder 11.41 11.08 4 145592 50 90482801
Upper-airway cough syndrome 11.41 11.08 5 145591 15130 90467721
Injection site warmth 11.40 11.08 7 145589 17508 90465343
Skin fissures 11.36 11.08 10 145586 20799 90462052
Myocardial infarction 11.36 11.08 112 145484 105860 90376991
Carpal tunnel syndrome 11.35 11.08 13 145583 23915 90458936
Labelled drug-drug interaction medication error 11.34 11.08 50 145546 14532 90468319
Blood bicarbonate decreased 11.34 11.08 19 145577 3100 90479751
Hyporeflexia 11.33 11.08 16 145580 2250 90480601
Therapeutic response shortened 11.33 11.08 12 145584 22867 90459984
Pregnancy with contraceptive patch 11.31 11.08 3 145593 13 90482838
Idiopathic generalised epilepsy 11.31 11.08 3 145593 13 90482838
Glaucoma 11.30 11.08 10 145586 20745 90462106
Gliosis 11.26 11.08 8 145588 487 90482364
Copper deficiency 11.24 11.08 5 145591 121 90482730
Gestational diabetes 11.23 11.08 40 145556 10542 90472309
Hypoxia 11.22 11.08 171 145425 72228 90410623
Pyroglutamic acidosis 11.22 11.08 12 145584 1268 90481583
Bone density decreased 11.20 11.08 7 145589 17338 90465513
Cataplexy 11.18 11.08 13 145583 1507 90481344
Product quality issue 11.15 11.08 78 145518 79247 90403604
Blood albumin decreased 11.14 11.08 55 145541 16748 90466103
Aphthous ulcer 11.13 11.08 7 145589 17280 90465571
Urine calcium decreased 11.13 11.08 3 145593 14 90482837
Intervertebral disc degeneration 11.11 11.08 7 145589 17267 90465584
Spinal fusion surgery 11.08 11.08 3 145593 12280 90470571

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1967.17 11.66 2334 156923 118227 42343851
Hyperammonaemia 1540.55 11.66 697 158560 7169 42454909
Drug interaction 1537.93 11.66 3196 156061 263803 42198275
Aggression 1101.57 11.66 1072 158185 43091 42418987
Hyperammonaemic encephalopathy 983.57 11.66 375 158882 2383 42459695
Foetal anticonvulsant syndrome 977.88 11.66 303 158954 899 42461179
Dysmorphism 971.49 11.66 391 158866 2925 42459153
Neuroleptic malignant syndrome 893.42 11.66 698 158559 20774 42441304
Status epilepticus 810.19 11.66 579 158678 14999 42447079
Somnolence 690.34 11.66 1585 157672 139520 42322558
Epilepsy 651.66 11.66 635 158622 25536 42436542
Psychotic disorder 630.65 11.66 656 158601 28552 42433526
Foetal exposure during pregnancy 614.75 11.66 819 158438 46492 42415586
Multiple-drug resistance 590.29 11.66 358 158899 6964 42455114
Autism spectrum disorder 576.12 11.66 262 158995 2726 42459352
Generalised tonic-clonic seizure 574.05 11.66 595 158662 25784 42436294
Extrapyramidal disorder 551.07 11.66 471 158786 15941 42446137
Sopor 540.04 11.66 425 158832 12777 42449301
Dyspnoea 530.48 11.66 525 158732 442096 42019982
Psychomotor skills impaired 518.75 11.66 292 158965 4912 42457166
Developmental delay 502.28 11.66 243 159014 2939 42459139
Speech disorder developmental 500.23 11.66 219 159038 2066 42460012
Mania 491.65 11.66 367 158890 10180 42451898
Sedation 490.23 11.66 587 158670 29888 42432190
Abnormal behaviour 486.67 11.66 546 158711 25905 42436173
Psychomotor retardation 466.25 11.66 257 159000 4142 42457936
Diarrhoea 459.26 11.66 633 158624 460216 42001862
Parkinsonism 456.22 11.66 352 158905 10271 42451807
Ammonia increased 447.08 11.66 255 159002 4404 42457674
Febrile neutropenia 444.42 11.66 79 159178 185624 42276454
Agitation 441.42 11.66 831 158426 63483 42398595
Learning disorder 435.54 11.66 162 159095 951 42461127
Depression 425.67 11.66 1139 158118 110224 42351854
Behaviour disorder 412.95 11.66 282 158975 6772 42455306
Intellectual disability 406.68 11.66 180 159077 1747 42460331
Toxicity to various agents 388.30 11.66 1789 157468 227347 42234731
Cognitive disorder 387.30 11.66 554 158703 33618 42428460
Arthralgia 383.26 11.66 144 159113 205094 42256984
Salivary hypersecretion 379.52 11.66 320 158937 10623 42451455
Coma 362.49 11.66 688 158569 52866 42409212
Irritability 362.23 11.66 485 158772 27643 42434435
Psychomotor hyperactivity 350.64 11.66 306 158951 10652 42451426
Language disorder 348.90 11.66 175 159082 2300 42459778
Schizophrenia 340.38 11.66 296 158961 10254 42451824
Akathisia 338.76 11.66 294 158963 10157 42451921
Death 334.08 11.66 798 158459 470387 41991691
Ataxia 333.37 11.66 354 158903 15771 42446307
Petit mal epilepsy 332.15 11.66 193 159064 3457 42458621
Granulocytopenia 310.43 11.66 238 159019 6876 42455202
Antipsychotic drug level increased 307.95 11.66 201 159056 4465 42457613
Disturbance in attention 306.34 11.66 462 158795 29404 42432674
Suicide attempt 298.15 11.66 581 158676 45519 42416559
Paranoia 290.09 11.66 308 158949 13718 42448360
Suicidal ideation 288.68 11.66 588 158669 47573 42414505
Intentional overdose 287.10 11.66 610 158647 50846 42411232
Acute kidney injury 284.67 11.66 592 158665 366745 42095333
Nausea 284.16 11.66 668 158589 396131 42065947
Anaemia 277.38 11.66 386 158871 279892 42182186
Overdose 268.01 11.66 934 158323 104330 42357748
Treatment noncompliance 266.09 11.66 493 158764 37179 42424899
Drug level increased 265.44 11.66 403 158854 25797 42436281
Antipsychotic drug level below therapeutic 259.11 11.66 157 159100 3047 42459031
Fatigue 258.82 11.66 804 158453 434837 42027241
Intentional self-injury 254.58 11.66 299 158958 14903 42447175
Catatonia 246.85 11.66 197 159060 6042 42456036
Tremor 245.81 11.66 859 158398 96070 42366008
Attention deficit hyperactivity disorder 242.89 11.66 149 159108 2959 42459119
Tardive dyskinesia 241.16 11.66 203 159054 6721 42455357
Electroencephalogram abnormal 240.38 11.66 146 159111 2846 42459232
Congenital nose malformation 238.13 11.66 69 159188 149 42461929
Hallucination, auditory 235.16 11.66 284 158973 14580 42447498
Dysgraphia 233.55 11.66 135 159122 2393 42459685
Drug ineffective 232.92 11.66 3467 155790 626730 41835348
Mental impairment 232.91 11.66 258 158999 12059 42450019
Psychiatric decompensation 228.83 11.66 161 159096 4061 42458017
Delusion 224.14 11.66 276 158981 14458 42447620
Disinhibition 223.92 11.66 154 159103 3741 42458337
Hypospadias 221.67 11.66 148 159109 3419 42458659
Atrial fibrillation 221.40 11.66 123 159134 139470 42322608
Delirium 220.73 11.66 557 158700 51962 42410116
Neuropathy peripheral 217.60 11.66 56 159201 101797 42360281
Pruritus 217.20 11.66 231 159026 188540 42273538
Speech disorder 216.91 11.66 390 158867 28731 42433347
Pain in extremity 214.95 11.66 150 159107 150454 42311624
Malignant neoplasm progression 212.51 11.66 70 159187 108330 42353748
Disease progression 210.47 11.66 139 159118 143517 42318561
Depressed level of consciousness 210.26 11.66 517 158740 47453 42414625
Euphoric mood 210.07 11.66 182 159075 6271 42455807
Pain 202.79 11.66 379 158878 244469 42217609
Enuresis 200.22 11.66 126 159131 2622 42459456
Anticonvulsant drug level increased 199.29 11.66 105 159152 1538 42460540
Muscle rigidity 193.36 11.66 232 159025 11827 42450251
Dysarthria 192.78 11.66 446 158811 39361 42422717
Dystonia 188.80 11.66 236 159021 12554 42449524
Depressive symptom 188.36 11.66 138 159119 3715 42458363
Hypertelorism 188.25 11.66 75 159182 544 42461534
Blood creatine phosphokinase increased 188.02 11.66 498 158759 47840 42414238
Pneumonia 185.36 11.66 880 158377 421269 42040809
Obsessive-compulsive disorder 183.65 11.66 172 159085 6571 42455507
Partial seizures 182.19 11.66 161 159096 5698 42456380
Drug level decreased 180.10 11.66 204 159053 9773 42452305
Cardiac failure congestive 179.16 11.66 49 159208 85553 42376525
Dyskinesia 177.66 11.66 331 158926 25059 42437019
Anticonvulsant drug level decreased 176.75 11.66 88 159169 1137 42460941
Schizoaffective disorder 176.16 11.66 103 159154 1867 42460211
Myoclonic epilepsy 175.19 11.66 97 159160 1577 42460501
Myocardial infarction 174.95 11.66 125 159132 123884 42338194
Cough 174.23 11.66 247 159010 177856 42284222
Hypotonia 169.39 11.66 193 159064 9306 42452772
Increased appetite 169.16 11.66 187 159070 8719 42453359
Thrombosis 168.43 11.66 27 159230 68484 42393594
Encephalopathy 168.07 11.66 433 158824 40900 42421178
Altered state of consciousness 166.76 11.66 350 158907 28909 42433169
Wrong patient received product 163.22 11.66 123 159134 3460 42458618
Myocarditis 161.10 11.66 269 158988 18669 42443409
Mental disorder 159.98 11.66 261 158996 17768 42444310
Product residue present 157.84 11.66 110 159147 2731 42459347
Prescribed overdose 157.42 11.66 217 159040 12710 42449368
Gastrointestinal haemorrhage 153.61 11.66 87 159170 97639 42364439
Dyspraxia 153.27 11.66 60 159197 413 42461665
Interstitial lung disease 153.17 11.66 51 159206 78411 42383667
Astigmatism 152.81 11.66 82 159175 1249 42460829
Talipes 151.67 11.66 98 159159 2138 42459940
Cytokine release syndrome 151.42 11.66 3 159254 44524 42417554
Anticonvulsant drug level above therapeutic 148.52 11.66 66 159191 647 42461431
COVID-19 148.26 11.66 129 159128 115819 42346259
Asthenia 147.37 11.66 546 158711 280247 42181831
Disorientation 146.70 11.66 380 158877 36009 42426069
Therapeutic product effect variable 146.69 11.66 109 159148 3000 42459078
Pneumonia aspiration 145.65 11.66 465 158792 49613 42412465
Motor developmental delay 145.49 11.66 65 159192 646 42461432
Joint swelling 144.10 11.66 38 159219 67984 42394094
Peripheral swelling 143.84 11.66 79 159178 90191 42371887
Abdominal pain 143.74 11.66 311 158946 190160 42271918
Strabismus 142.49 11.66 96 159161 2252 42459826
Tearfulness 141.64 11.66 112 159145 3388 42458690
Plasma cell myeloma 139.09 11.66 10 159247 47568 42414510
Learning disability 138.80 11.66 53 159204 338 42461740
Cerebellar atrophy 138.38 11.66 64 159193 694 42461384
Product substitution issue 138.19 11.66 190 159067 11100 42450978
Cryptorchism 137.88 11.66 89 159168 1938 42460140
Pulmonary embolism 137.88 11.66 146 159111 119466 42342612
Fanconi syndrome 137.63 11.66 85 159172 1709 42460369
Depression suicidal 135.98 11.66 106 159151 3139 42458939
Infusion related reaction 134.58 11.66 31 159226 60775 42401303
Neurodevelopmental disorder 134.11 11.66 54 159203 404 42461674
Tonic convulsion 133.39 11.66 81 159176 1578 42460500
Drug reaction with eosinophilia and systemic symptoms 132.82 11.66 402 158855 41673 42420405
Focal dyscognitive seizures 131.96 11.66 77 159180 1390 42460688
Educational problem 131.73 11.66 57 159200 521 42461557
Communication disorder 130.95 11.66 98 159159 2727 42459351
Sepsis 128.73 11.66 353 158904 198981 42263097
Mucosal inflammation 127.04 11.66 17 159240 49357 42412721
Thinking abnormal 126.84 11.66 145 159112 7016 42455062
Restlessness 126.81 11.66 314 158943 28935 42433143
Rheumatoid arthritis 126.76 11.66 8 159249 42432 42419646
Prostate cancer 125.98 11.66 11 159246 44632 42417446
Coordination abnormal 124.37 11.66 152 159105 7898 42454180
Joint laxity 123.96 11.66 50 159207 376 42461702
Foot deformity 122.39 11.66 121 159136 4947 42457131
Myopia 122.08 11.66 70 159187 1221 42460857
Developmental coordination disorder 121.50 11.66 42 159215 192 42461886
Myoclonus 121.29 11.66 224 159033 16841 42445237
Lip disorder 121.17 11.66 52 159205 465 42461613
Drooling 119.65 11.66 111 159146 4188 42457890
Oculogyric crisis 118.84 11.66 77 159180 1688 42460390
Drug level below therapeutic 118.42 11.66 134 159123 6411 42455667
Psychotic symptom 117.73 11.66 86 159171 2304 42459774
Cerebral atrophy 116.64 11.66 118 159139 4961 42457117
Impulsive behaviour 116.61 11.66 86 159171 2339 42459739
Congenital oral malformation 116.60 11.66 26 159231 3 42462075
Hypertonia 116.34 11.66 117 159140 4884 42457194
Sudden unexplained death in epilepsy 113.52 11.66 50 159207 479 42461599
Priapism 112.24 11.66 129 159128 6278 42455800
Renal failure 110.61 11.66 232 159025 143494 42318584
Hypotonia neonatal 110.52 11.66 69 159188 1415 42460663
Bradyphrenia 109.58 11.66 116 159141 5146 42456932
Ascites 108.59 11.66 38 159219 56640 42405438
Obesity 108.24 11.66 209 159048 16250 42445828
Chills 108.18 11.66 115 159142 93951 42368127
Back pain 108.14 11.66 230 159027 141546 42320532
Anticonvulsant drug level below therapeutic 107.88 11.66 53 159204 664 42461414
Cardiac failure 107.60 11.66 145 159112 106711 42355367
Hypomania 107.43 11.66 83 159174 2425 42459653
Oedema peripheral 106.95 11.66 217 159040 135859 42326219
Low set ears 105.65 11.66 47 159210 462 42461616
Pancreatitis acute 105.28 11.66 320 158937 33244 42428834
Anxiety 105.19 11.66 781 158476 117779 42344299
Pectus excavatum 104.96 11.66 38 159219 204 42461874
Myalgia 104.43 11.66 123 159134 95957 42366121
Bipolar disorder 102.90 11.66 98 159159 3824 42458254
Congenital foot malformation 102.37 11.66 44 159213 395 42461683
Hypermetropia 101.51 11.66 46 159211 474 42461604
Antipsychotic drug level above therapeutic 101.47 11.66 62 159195 1222 42460856
Eosinophilic pleural effusion 99.37 11.66 40 159217 299 42461779
Chest pain 99.36 11.66 235 159022 139295 42322783
Atonic seizures 98.02 11.66 42 159215 374 42461704
Asterixis 95.00 11.66 61 159196 1316 42460762
Drug withdrawal convulsions 94.11 11.66 60 159197 1278 42460800
Disturbance in social behaviour 93.65 11.66 67 159190 1736 42460342
Fine motor delay 93.32 11.66 36 159221 237 42461841
Coronary artery disease 93.11 11.66 42 159215 53678 42408400
Bradykinesia 92.80 11.66 108 159149 5328 42456750
Psychogenic seizure 92.67 11.66 42 159215 433 42461645
Chest discomfort 92.48 11.66 62 159195 63554 42398524
Hypothermia 92.38 11.66 167 159090 12348 42449730
Congenital hand malformation 91.47 11.66 46 159211 608 42461470
Scoliosis 91.45 11.66 83 159174 3043 42459035
Anger 91.41 11.66 170 159087 12848 42449230
Weight increased 91.09 11.66 703 158554 107280 42354798
Headache 90.68 11.66 524 158733 238845 42223233
Renal impairment 89.86 11.66 172 159085 110056 42352022
Persecutory delusion 89.62 11.66 87 159170 3477 42458601
Blood pressure increased 88.49 11.66 153 159104 101775 42360303
Arthritis 88.13 11.66 24 159233 42041 42420037
Toxic encephalopathy 88.10 11.66 119 159138 6834 42455244
Completed suicide 87.56 11.66 639 158618 95826 42366252
Confusional state 86.86 11.66 983 158274 166614 42295464
Rash 86.83 11.66 642 158615 276312 42185766
Erythema 85.89 11.66 173 159084 108620 42353458
Dyspnoea exertional 85.68 11.66 40 159217 50108 42411970
Nystagmus 85.17 11.66 103 159154 5293 42456785
Antipsychotic drug level decreased 85.16 11.66 54 159203 1139 42460939
Mental status changes 84.87 11.66 347 158910 41768 42420310
Epistaxis 84.59 11.66 75 159182 66751 42395327
Prominent epicanthal folds 84.45 11.66 30 159227 151 42461927
Echolalia 84.22 11.66 37 159220 352 42461726
Urticaria 83.46 11.66 92 159165 73944 42388134
Myelosuppression 83.07 11.66 24 159233 40437 42421641
Clinodactyly 82.87 11.66 33 159224 239 42461839
Drug resistance 82.81 11.66 299 158958 33949 42428129
Oppositional defiant disorder 82.26 11.66 41 159216 531 42461547
Ligament laxity 81.90 11.66 20 159237 13 42462065
Serotonin syndrome 81.60 11.66 247 159010 25598 42436480
Haematochezia 80.92 11.66 60 159197 58376 42403702
Affect lability 80.42 11.66 87 159170 3957 42458121
Abdominal discomfort 80 11.66 98 159159 75157 42386921
Dizziness 79.93 11.66 574 158683 248680 42213398
Hyperkalaemia 79.15 11.66 111 159146 80347 42381731
Haemoptysis 78.60 11.66 37 159220 46130 42415948
Injection site pain 77.92 11.66 61 159196 57737 42404341
Stereotypy 77.87 11.66 45 159212 797 42461281
Swelling 77.77 11.66 55 159202 54830 42407248
Fine motor skill dysfunction 76.64 11.66 65 159192 2174 42459904
Personality disorder 76.50 11.66 50 159207 1113 42460965
Torticollis 76.00 11.66 53 159204 1317 42460761
Ear disorder 75.91 11.66 62 159195 1966 42460112
Postictal psychosis 75.03 11.66 29 159228 192 42461886
Personal relationship issue 74.97 11.66 32 159225 282 42461796
Sinusitis 74.42 11.66 42 159215 47250 42414828
Acute myocardial infarction 73.95 11.66 65 159192 58100 42403978
Hypermobility syndrome 73.69 11.66 33 159224 330 42461748
Psychiatric symptom 73.64 11.66 85 159172 4156 42457922
Dyslexia 73.25 11.66 33 159224 335 42461743
Hypersensitivity 73.04 11.66 98 159159 72272 42389806
Hypernatraemia 72.95 11.66 133 159124 9899 42452179
Gaze palsy 72.91 11.66 59 159198 1846 42460232
Neutrophil count increased 72.90 11.66 200 159057 19604 42442474
Rectal haemorrhage 72.56 11.66 48 159209 49558 42412520
Stevens-Johnson syndrome 71.95 11.66 214 159043 21964 42440114
Decreased eye contact 70.85 11.66 36 159221 487 42461591
Congenital anomaly 70.41 11.66 53 159204 1488 42460590
Drug abuse 70.25 11.66 648 158609 104123 42357955
Fluid retention 70.19 11.66 16 159241 31603 42430475
Stupor 70.12 11.66 72 159185 3081 42458997
Posture abnormal 69.98 11.66 65 159192 2456 42459622
Hypoaesthesia 69.88 11.66 99 159158 71364 42390714
Herpes zoster 69.58 11.66 29 159228 38848 42423230
Eosinophilia 69.42 11.66 275 158982 32624 42429454
Hyperprolactinaemia 69.34 11.66 60 159197 2063 42460015
Sedation complication 69.20 11.66 69 159188 2850 42459228
Septic shock 68.79 11.66 150 159107 91522 42370556
Pneumonitis 68.65 11.66 35 159222 41683 42420395
Microcephaly 68.48 11.66 43 159214 891 42461187
Dysphoria 68.29 11.66 67 159190 2713 42459365
Gait disturbance 68.18 11.66 611 158646 97389 42364689
Exposure during pregnancy 68.17 11.66 118 159139 8430 42453648
Cerebrovascular accident 68.05 11.66 165 159092 96995 42365083
Weight decreased 68.04 11.66 476 158781 207472 42254606
Dry skin 67.75 11.66 49 159208 48289 42413789
Pancytopenia 67.64 11.66 220 159037 117523 42344555
Cogwheel rigidity 67.28 11.66 55 159202 1746 42460332
Abdominal pain upper 67.23 11.66 129 159128 82480 42379598
Anaphylactic reaction 67.20 11.66 38 159219 42705 42419373
Psoriasis 67.17 11.66 50 159207 48554 42413524
Leukopenia 67.15 11.66 494 158763 74252 42387826
Bipolar I disorder 66.70 11.66 41 159216 817 42461261
Homicidal ideation 66.16 11.66 66 159191 2728 42459350
Plagiocephaly 66.08 11.66 36 159221 566 42461512
Melaena 66.04 11.66 31 159226 38715 42423363
Influenza 65.00 11.66 82 159175 62093 42399985
Craniosynostosis 64.92 11.66 32 159225 404 42461674
Differential white blood cell count abnormal 64.61 11.66 53 159204 1691 42460387
White blood cell count increased 64.52 11.66 336 158921 44751 42417327
General physical health deterioration 63.33 11.66 320 158937 150926 42311152
Nephrogenic diabetes insipidus 62.90 11.66 50 159207 1524 42460554
Social avoidant behaviour 62.78 11.66 70 159187 3294 42458784
Physical assault 62.71 11.66 43 159214 1039 42461039
Lethargy 62.04 11.66 342 158915 46548 42415530
Ear malformation 62.02 11.66 29 159228 323 42461755
Hyperkinesia 61.95 11.66 56 159201 2042 42460036
Muscle spasms 61.95 11.66 144 159113 85900 42376178
Motor dysfunction 61.79 11.66 110 159147 8036 42454042
Pneumocystis jirovecii pneumonia 61.70 11.66 10 159247 25171 42436907
Encopresis 61.45 11.66 24 159233 164 42461914
Cytomegalovirus infection 61.29 11.66 22 159235 32284 42429794
Pyrexia 61.00 11.66 1071 158186 392971 42069107
Psoriatic arthropathy 60.98 11.66 10 159247 24957 42437121
Emotional disorder 60.94 11.66 95 159162 6219 42455859
Basal cell carcinoma 60.49 11.66 7 159250 22726 42439352
Upper gastrointestinal haemorrhage 60.33 11.66 19 159238 30280 42431798
Brain oedema 60.21 11.66 165 159092 16162 42445916
Faecaloma 60.04 11.66 94 159163 6176 42455902
Pressure of speech 59.62 11.66 33 159224 536 42461542
Product dose omission issue 58.87 11.66 337 158920 154028 42308050
Dysgeusia 58.82 11.66 27 159230 34162 42427916
Tumour lysis syndrome 58.77 11.66 7 159250 22224 42439854
Excessive eye blinking 58.50 11.66 34 159223 609 42461469
Nasal disorder 58.10 11.66 53 159204 1956 42460122
Blood prolactin increased 57.60 11.66 56 159201 2242 42459836
Malaise 57.59 11.66 511 158746 211645 42250433
Stomatitis 57.31 11.66 62 159195 50267 42411811
Chronic obstructive pulmonary disease 57.29 11.66 92 159165 63022 42399056
Tachycardia 56.94 11.66 603 158654 100484 42361594
Pancreatitis 56.85 11.66 315 158942 42953 42419125
Sexually inappropriate behaviour 56.83 11.66 33 159224 590 42461488
Asocial behaviour 56.74 11.66 18 159239 59 42462019
Seizure cluster 56.54 11.66 26 159231 278 42461800
Pulmonary fibrosis 56.31 11.66 15 159242 26666 42435412
Neoplasm progression 56.31 11.66 19 159238 28981 42433097
Frequent bowel movements 55.95 11.66 7 159250 21400 42440678
Lung disorder 55.73 11.66 58 159199 47865 42414213
Apathy 55.58 11.66 107 159150 8299 42453779
Chronic kidney disease 55.13 11.66 57 159200 47184 42414894
Angina pectoris 55.02 11.66 27 159230 32869 42429209
Blood creatinine increased 54.90 11.66 218 159039 109785 42352293
Dehydration 54.86 11.66 308 158949 141459 42320619
Urinary incontinence 54.79 11.66 192 159065 21476 42440602
Hyperacusis 54.33 11.66 38 159219 949 42461129
Hepatic function abnormal 54.09 11.66 354 158903 51213 42410865
Partial seizures with secondary generalisation 53.94 11.66 28 159229 397 42461681
Nose deformity 53.42 11.66 24 159233 242 42461836
Musculoskeletal pain 53.33 11.66 29 159228 33311 42428767
Palmar-plantar erythrodysaesthesia syndrome 53.14 11.66 7 159250 20575 42441503
Osteonecrosis of jaw 52.91 11.66 5 159252 19044 42443034
Syncope 52.84 11.66 192 159065 99214 42362864
Atrial septal defect 52.60 11.66 101 159156 7818 42454260
Reading disorder 52.54 11.66 30 159227 519 42461559
Diabetes insipidus 52.39 11.66 67 159190 3646 42458432
Drug level changed 52.38 11.66 27 159230 377 42461701
Change in seizure presentation 52.13 11.66 25 159232 296 42461782
Cellulitis 52.02 11.66 94 159163 61491 42400587
Multiple congenital abnormalities 51.98 11.66 30 159227 530 42461548
Bronchopulmonary aspergillosis 51.65 11.66 6 159251 19423 42442655
Bladder cancer 51.54 11.66 3 159254 17044 42445034
Camptodactyly congenital 51.44 11.66 19 159238 109 42461969
Cardiogenic shock 51.43 11.66 35 159222 35605 42426473
High arched palate 50.31 11.66 16 159241 53 42462025
Transient ischaemic attack 50.22 11.66 32 159225 33707 42428371
Arthropathy 49.95 11.66 24 159233 29573 42432505
Acute myeloid leukaemia 49.93 11.66 11 159246 22245 42439833
COVID-19 pneumonia 49.89 11.66 10 159247 21603 42440475
Brugada syndrome 49.86 11.66 37 159220 1016 42461062
Affective disorder 49.80 11.66 84 159173 5876 42456202
Paraesthesia 49.67 11.66 127 159130 73332 42388746
Eosinophil count decreased 49.62 11.66 64 159193 3512 42458566
Neuralgia 49.45 11.66 17 159240 25630 42436448
Infantile spasms 49.28 11.66 23 159234 255 42461823
Haematuria 49.01 11.66 88 159169 57711 42404367
Haemorrhage 48.89 11.66 95 159162 60468 42401610
Abdominal distension 48.52 11.66 124 159133 71611 42390467
Postictal paralysis 48.32 11.66 25 159232 352 42461726
Dyslipidaemia 48.31 11.66 108 159149 9310 42452768
Choreoathetosis 48.15 11.66 37 159220 1072 42461006
Congenital eyelid malformation 47.78 11.66 17 159240 86 42461992
Arnold-Chiari malformation 47.64 11.66 25 159232 363 42461715
Knee deformity 47.63 11.66 32 159225 747 42461331
Bacteraemia 47.59 11.66 17 159240 25023 42437055
Skin exfoliation 47.52 11.66 51 159206 41502 42420576
Heart rate decreased 47.43 11.66 40 159217 36492 42425586
Bruxism 47.28 11.66 49 159208 2120 42459958
Infection 46.95 11.66 237 159020 111831 42350247
Anaphylactic shock 46.37 11.66 15 159242 23502 42438576
Colitis 46.04 11.66 64 159193 46508 42415570
Congenital hair disorder 45.93 11.66 10 159247 0 42462078
Cerebral ventricle dilatation 45.85 11.66 35 159222 1004 42461074
Spina bifida 45.55 11.66 25 159232 399 42461679
Executive dysfunction 45.47 11.66 22 159235 266 42461812
Apraxia 45.38 11.66 41 159216 1494 42460584
Pleurothotonus 45.28 11.66 37 159220 1174 42460904
Choking 45.16 11.66 83 159174 6215 42455863
Carnitine deficiency 44.71 11.66 17 159240 107 42461971
Drug hypersensitivity 44.65 11.66 205 159052 99184 42362894
Full blood count decreased 44.46 11.66 11 159246 20549 42441529
End stage renal disease 44.30 11.66 5 159252 16553 42445525
Inappropriate schedule of product administration 44.16 11.66 196 159061 95706 42366372
Acidosis hyperchloraemic 44.15 11.66 29 159228 651 42461427
Congenital eye disorder 44.14 11.66 20 159237 206 42461872
Tooth malformation 44.07 11.66 19 159238 172 42461906
Synovitis 43.47 11.66 4 159253 15563 42446515
Normal pressure hydrocephalus 43.32 11.66 19 159238 180 42461898
Wheezing 43.30 11.66 87 159170 54694 42407384
Head titubation 43.20 11.66 25 159232 444 42461634
Coma scale abnormal 43.10 11.66 68 159189 4497 42457581
Pneumothorax 43.04 11.66 17 159240 23526 42438552
Homicide 42.99 11.66 32 159225 883 42461195
Delusional disorder, unspecified type 42.83 11.66 30 159227 751 42461327
Leukaemia 42.57 11.66 77 159180 5695 42456383
Oedema 42.47 11.66 81 159176 51920 42410158
Angioedema 42.36 11.66 58 159199 42419 42419659
Rhinorrhoea 42.29 11.66 34 159223 31760 42430318
Eczema 42.23 11.66 39 159218 34047 42428031
Manic symptom 41.91 11.66 19 159238 196 42461882
Flushing 41.73 11.66 46 159211 36982 42425096
Hyperosmolar state 41.72 11.66 25 159232 475 42461603
Flight of ideas 41.53 11.66 22 159235 326 42461752
Carnitine decreased 41.34 11.66 9 159248 0 42462078
Gout 41.22 11.66 27 159230 28028 42434050
Nipple disorder 41.00 11.66 19 159238 207 42461871
Febrile convulsion 40.67 11.66 28 159229 681 42461397
Head discomfort 40.67 11.66 71 159186 5106 42456972
Crying 40.58 11.66 80 159177 6314 42455764
Stress 40.54 11.66 64 159193 44148 42417930
Autonomic nervous system imbalance 40.50 11.66 54 159203 3062 42459016
Self-injurious ideation 40.36 11.66 42 159215 1826 42460252
Confabulation 40.31 11.66 17 159240 145 42461933
Logorrhoea 40.15 11.66 51 159206 2756 42459322
Post-injection delirium sedation syndrome 39.65 11.66 26 159231 582 42461496
Intelligence test abnormal 39.65 11.66 12 159245 32 42462046
Memory impairment 39.57 11.66 322 158935 49900 42412178
Anisometropia 39.38 11.66 13 159244 50 42462028
Congenital myopia 39.00 11.66 14 159243 73 42462005
Polydipsia 38.49 11.66 64 159193 4424 42457654
Blood pressure systolic increased 38.35 11.66 29 159228 27939 42434139
Monocyte count increased 38.29 11.66 73 159184 5621 42456457
Osteoarthritis 37.92 11.66 22 159235 24383 42437695
Hot flush 37.91 11.66 18 159239 22333 42439745
Nasopharyngitis 37.87 11.66 173 159084 83823 42378255
Hallucination, visual 37.54 11.66 167 159090 20853 42441225
Loss of personal independence in daily activities 37.43 11.66 316 158941 49500 42412578
Ear infection 37.29 11.66 119 159138 12685 42449393
Night sweats 37.20 11.66 14 159243 19955 42442123
Staphylococcal infection 36.94 11.66 52 159205 37591 42424487
Depressed mood 36.78 11.66 179 159078 23205 42438873
Blood pressure fluctuation 36.77 11.66 28 159229 26880 42435198
Pulmonary mass 36.56 11.66 8 159249 16257 42445821
Shock haemorrhagic 36.49 11.66 8 159249 16234 42445844
Necrosis ischaemic 36.44 11.66 21 159236 370 42461708
Bronchiectasis 36.41 11.66 11 159246 18008 42444070
Anion gap increased 36.41 11.66 42 159215 2052 42460026
Mood altered 36.27 11.66 105 159152 10613 42451465
Renal disorder 36.09 11.66 33 159224 28947 42433131
Metastases to bone 36.01 11.66 6 159251 14803 42447275
Chorea 35.84 11.66 35 159222 1409 42460669
Sluggishness 35.37 11.66 57 159200 3839 42458239
Coloboma 35.36 11.66 15 159242 130 42461948
Feeling hot 35.32 11.66 22 159235 23460 42438618
Bronchiolitis 35.26 11.66 57 159200 3849 42458229
Nephrolithiasis 35.03 11.66 52 159205 36778 42425300
Bone pain 34.82 11.66 23 159234 23769 42438309
Visuospatial deficit 34.74 11.66 14 159243 105 42461973
Clostridium difficile colitis 34.71 11.66 18 159239 21234 42440844
Duodenal ulcer 34.71 11.66 3 159254 12276 42449802
Paradoxical drug reaction 34.68 11.66 63 159194 4675 42457403
Congenital nail disorder 34.46 11.66 11 159246 37 42462041
Appendicitis 34.35 11.66 17 159240 20596 42441482
Drug intolerance 34.29 11.66 169 159088 80255 42381823
Refraction disorder 34.24 11.66 11 159246 38 42462040
Arachnodactyly 34.21 11.66 8 159249 3 42462075
Antisocial behaviour 34.18 11.66 21 159236 418 42461660
Intentional product use issue 34.17 11.66 145 159112 71688 42390390
Soliloquy 34.12 11.66 24 159233 605 42461473
Prognathism 33.97 11.66 14 159243 112 42461966
Deep vein thrombosis 33.81 11.66 160 159097 76797 42385281
Muscular weakness 33.60 11.66 179 159078 83319 42378759
Congenital knee deformity 33.54 11.66 14 159243 116 42461962
Blood osmolarity decreased 33.44 11.66 24 159233 625 42461453
Magnetic resonance imaging head abnormal 33.44 11.66 35 159222 1532 42460546
Flatulence 33.32 11.66 27 159230 25125 42436953
Drop attacks 33.11 11.66 23 159234 568 42461510
Muscle tone disorder 33.10 11.66 16 159241 193 42461885
Dyscalculia 33.02 11.66 13 159244 91 42461987
Illiteracy 32.88 11.66 8 159249 5 42462073
Emotional disorder of childhood 32.79 11.66 11 159246 45 42462033
Nephropathy toxic 32.74 11.66 11 159246 16827 42445251
Oscillopsia 32.45 11.66 17 159240 246 42461832
Rash pruritic 32.40 11.66 47 159210 33556 42428522
Hyperphosphataemia 32.23 11.66 5 159252 12999 42449079
Heart disease congenital 32.20 11.66 33 159224 1409 42460669
Anticonvulsant drug level abnormal 32.18 11.66 10 159247 30 42462048
Resting tremor 32.11 11.66 28 159229 973 42461105
Nasal septum disorder 32.05 11.66 11 159246 49 42462029
Transplant rejection 31.97 11.66 6 159251 13582 42448496
Myelodysplastic syndrome 31.94 11.66 23 159234 22722 42439356
Retinal coloboma 31.86 11.66 9 159248 17 42462061
Perseveration 31.76 11.66 13 159244 102 42461976
Hypervolaemia 31.68 11.66 24 159233 23101 42438977
Paroxysmal perceptual alteration 31.65 11.66 16 159241 214 42461864
Self-destructive behaviour 31.47 11.66 19 159238 366 42461712
Injection site swelling 31.45 11.66 12 159245 16961 42445117
Alcohol abuse 31.12 11.66 55 159202 3994 42458084
Retrognathia 31.11 11.66 17 159240 269 42461809
Hypokalaemia 30.99 11.66 150 159107 71571 42390507
Localised infection 30.76 11.66 19 159238 20354 42441724
Inappropriate antidiuretic hormone secretion 30.75 11.66 133 159124 16408 42445670
Aphasia 30.74 11.66 174 159083 23909 42438169
Distractibility 30.72 11.66 20 159237 442 42461636
Congenital astigmatism 30.70 11.66 11 159246 57 42462021
Neoplasm malignant 30.65 11.66 24 159233 22719 42439359
Epileptic encephalopathy 30.51 11.66 17 159240 280 42461798
Phobia 30.42 11.66 14 159243 150 42461928
Social (pragmatic) communication disorder 30.41 11.66 13 159244 115 42461963
Osteomyelitis 30.41 11.66 15 159242 18208 42443870
Wrong product administered 30.38 11.66 70 159187 6156 42455922
Congenital genital malformation 30.34 11.66 14 159243 151 42461927
Illness 30.32 11.66 29 159228 24901 42437177
Toe walking 30.30 11.66 8 159249 10 42462068
Pharyngeal disorder 30.24 11.66 26 159231 886 42461192
Patient isolation 30.19 11.66 10 159247 39 42462039
Inappropriate affect 30.18 11.66 24 159233 732 42461346
Metabolic syndrome 29.91 11.66 37 159220 1946 42460132
Intensive care unit acquired weakness 29.91 11.66 30 159227 1248 42460830
Rhabdomyolysis 29.89 11.66 433 158824 77586 42384492
Impaired reasoning 29.84 11.66 13 159244 121 42461957
Cardiac disorder 29.79 11.66 89 159168 48843 42413235
Delusion of grandeur 29.72 11.66 37 159220 1959 42460119
Lymphocyte count increased 29.70 11.66 54 159203 4010 42458068
Staring 29.65 11.66 33 159224 1550 42460528
Food interaction 29.63 11.66 27 159230 995 42461083
Hallucination 29.58 11.66 337 158920 57170 42404908
Negativism 29.50 11.66 19 159238 412 42461666
Developmental regression 29.42 11.66 10 159247 43 42462035
Blood bilirubin increased 29.37 11.66 72 159185 42180 42419898
Neural tube defect 29.05 11.66 10 159247 45 42462033
Tic 29.00 11.66 40 159217 2343 42459735
Convulsive threshold lowered 28.75 11.66 20 159237 495 42461583
Hyperhomocysteinaemia 28.69 11.66 16 159241 264 42461814
Balance disorder 28.60 11.66 288 158969 47357 42414721
Nodule 28.51 11.66 6 159251 12528 42449550
Lymphoma 28.47 11.66 9 159248 14312 42447766
Faeces discoloured 28.40 11.66 14 159243 17000 42445078
Limb hypoplasia congenital 28.35 11.66 8 159249 15 42462063
Respiratory failure 28.33 11.66 324 158933 127808 42334270
Developmental hip dysplasia 28.32 11.66 17 159240 324 42461754
Meningocele 28.26 11.66 9 159248 30 42462048
Ulcer 28.25 11.66 13 159244 16428 42445650
Drug ineffective for unapproved indication 28.17 11.66 280 158977 45883 42416195
Throat irritation 28.14 11.66 7 159250 13029 42449049
Judgement impaired 28.13 11.66 21 159236 582 42461496
Speech sound disorder 28.11 11.66 13 159244 141 42461937
Adrenal insufficiency 28.09 11.66 18 159239 18906 42443172
Hernia 28.03 11.66 4 159253 11069 42451009
Colitis ulcerative 27.89 11.66 34 159223 26141 42435937
Venoocclusive liver disease 27.84 11.66 3 159254 10299 42451779
Retinogram abnormal 27.79 11.66 13 159244 145 42461933
Cerebral infarction 27.75 11.66 46 159211 31123 42430955
Haemoglobin decreased 27.74 11.66 339 158918 132132 42329946
Candida infection 27.64 11.66 24 159233 21586 42440492
Withdrawal syndrome 27.62 11.66 119 159138 14656 42447422
Pneumonia bacterial 27.60 11.66 12 159245 15680 42446398
Decreased appetite 27.56 11.66 532 158725 192605 42269473
Factor XIII deficiency 27.56 11.66 6 159251 0 42462078
Congenital neurological disorder 27.56 11.66 6 159251 0 42462078
Taste disorder 27.52 11.66 3 159254 10204 42451874
Water intoxication 27.49 11.66 18 159239 402 42461676
Febrile bone marrow aplasia 27.43 11.66 3 159254 10178 42451900
Inflammation 27.39 11.66 53 159204 33794 42428284
Squamous cell carcinoma of skin 27.15 11.66 7 159250 12719 42449359
Productive cough 27.12 11.66 100 159157 51467 42410611
Diverticulitis 27.11 11.66 27 159230 22746 42439332
Hypophosphataemia 27.11 11.66 23 159234 20922 42441156
Dysmetria 27.10 11.66 23 159234 770 42461308
Social problem 27.08 11.66 28 159229 1208 42460870
Pathogen resistance 27.05 11.66 5 159252 11445 42450633
Gross motor delay 27.00 11.66 17 159240 354 42461724
Excessive masturbation 26.97 11.66 12 159245 118 42461960
Bacterial infection 26.87 11.66 39 159218 27840 42434238
Blood potassium decreased 26.85 11.66 22 159235 20362 42441716
Selective eating disorder 26.75 11.66 33 159224 1731 42460347
Hypotelorism of orbit 26.71 11.66 12 159245 121 42461957
Hepatic adenoma 26.70 11.66 10 159247 60 42462018
Bone marrow failure 26.63 11.66 52 159205 33041 42429037
Enterocolitis 26.56 11.66 3 159254 9926 42452152
Postural tremor 26.50 11.66 19 159238 494 42461584
Injection site erythema 26.35 11.66 22 159235 20173 42441905
Constipation 26.33 11.66 437 158820 161854 42300224
Spasmodic dysphonia 26.24 11.66 19 159238 502 42461576
Atrial flutter 26.17 11.66 16 159241 17235 42444843
Agranulocytosis 26.16 11.66 200 159057 30412 42431666
Inguinal hernia 26.11 11.66 83 159174 8829 42453249
Brain malformation 26.11 11.66 13 159244 168 42461910
Squamous cell carcinoma 26.10 11.66 8 159249 12974 42449104
Hypotension 26.09 11.66 748 158509 256883 42205195
Urinary tract infection 26.08 11.66 241 159016 99043 42363035
Oligoasthenozoospermia 25.98 11.66 7 159250 10 42462068
Type 2 diabetes mellitus 25.96 11.66 137 159120 18334 42443744
Blood triglycerides increased 25.95 11.66 123 159134 15773 42446305
Graft versus host disease 25.92 11.66 8 159249 12917 42449161
Cerebral haemorrhage 25.85 11.66 68 159189 38898 42423180
Postictal state 25.84 11.66 25 159232 995 42461083
Social anxiety disorder 25.83 11.66 20 159237 586 42461492
Oesophageal carcinoma 25.76 11.66 3 159254 9693 42452385
Failure to suspend medication 25.75 11.66 17 159240 385 42461693
Dacryostenosis congenital 25.72 11.66 9 159248 43 42462035
Gastrointestinal malformation 25.67 11.66 11 159246 98 42461980
Blood uric acid increased 25.64 11.66 13 159244 15534 42446544
Blood lactic acid increased 25.53 11.66 77 159180 7962 42454116
Growth retardation 25.46 11.66 38 159219 2394 42459684
Pancreatitis haemorrhagic 25.45 11.66 17 159240 393 42461685
Disorganised speech 25.43 11.66 29 159228 1399 42460679
Device related infection 25.36 11.66 23 159234 20256 42441822
Eating disorder 25.34 11.66 88 159169 9797 42452281
Strabismus congenital 25.27 11.66 8 159249 26 42462052
No adverse event 25.20 11.66 69 159188 38952 42423126
Acute coronary syndrome 25.16 11.66 12 159245 14853 42447225
Clonic convulsion 25.14 11.66 23 159234 852 42461226
Microstomia 25.14 11.66 6 159251 3 42462075
Choroidal coloboma 25.14 11.66 6 159251 3 42462075
Amblyopia 25.10 11.66 12 159245 141 42461937
Metastases to liver 24.97 11.66 15 159242 16311 42445767
Schizoaffective disorder bipolar type 24.95 11.66 12 159245 143 42461935
Tuberous sclerosis complex 24.93 11.66 10 159247 74 42462004
Deformity thorax 24.91 11.66 9 159248 48 42462030
Cleft palate 24.90 11.66 20 159237 619 42461459
Mutism 24.88 11.66 29 159228 1433 42460645
Middle insomnia 24.85 11.66 75 159182 7758 42454320
Injection site reaction 24.67 11.66 14 159243 15707 42446371
Electrocardiogram QT prolonged 24.67 11.66 281 158976 47664 42414414
Ventricular tachycardia 24.61 11.66 47 159210 30113 42431965
Clostridium difficile infection 24.61 11.66 29 159228 22630 42439448
Anomaly of external ear congenital 24.56 11.66 11 159246 110 42461968
Ornithine transcarbamoylase deficiency 24.52 11.66 7 159250 14 42462064
Metabolic acidosis 24.50 11.66 299 158958 51559 42410519
Otitis media 24.49 11.66 47 159210 3636 42458442
Haemorrhoids 24.39 11.66 17 159240 17080 42444998
Hypertension 24.33 11.66 459 158798 166745 42295333
Dermatitis atopic 24.30 11.66 8 159249 12396 42449682
Insomnia 24.29 11.66 596 158661 117657 42344421
Large intestine polyp 24.29 11.66 3 159254 9262 42452816
Impaired healing 24.27 11.66 17 159240 17036 42445042
Angular cheilitis 24.22 11.66 13 159244 198 42461880
Hallucination, tactile 24.19 11.66 19 159238 569 42461509
Grandiosity 24.14 11.66 15 159242 305 42461773
Hyponatraemia 24.13 11.66 522 158735 100940 42361138
Dry eye 24.06 11.66 14 159243 15492 42446586
Unresponsive to stimuli 24.01 11.66 200 159057 31203 42430875
Congenital scoliosis 23.97 11.66 11 159246 117 42461961
Presyncope 23.94 11.66 29 159228 22358 42439720
Neutrophil Pelger-Huet anomaly present 23.93 11.66 14 159243 254 42461824
Dyspepsia 23.90 11.66 77 159180 41275 42420803
Pelvic deformity 23.89 11.66 9 159248 55 42462023
Drug withdrawal syndrome 23.86 11.66 150 159107 21399 42440679
Cataract 23.84 11.66 49 159208 30555 42431523
Erectile dysfunction 23.71 11.66 167 159090 24746 42437332
SJS-TEN overlap 23.68 11.66 20 159237 665 42461413
International normalised ratio increased 23.67 11.66 96 159161 48072 42414006
Muscle contracture 23.64 11.66 28 159229 1407 42460671
Compulsive shopping 23.64 11.66 17 159240 444 42461634
Hyperthyroidism 23.64 11.66 12 159245 14329 42447749
Cytomegalovirus viraemia 23.54 11.66 5 159252 10372 42451706
Blood glucose increased 23.42 11.66 170 159087 73529 42388549
Pleural effusion 23.35 11.66 241 159016 96925 42365153
Automatism 23.33 11.66 11 159246 125 42461953
Hyperthermia 23.29 11.66 101 159156 12473 42449605
Laboratory test abnormal 23.29 11.66 31 159226 22947 42439131
Multiple organ dysfunction syndrome 23.19 11.66 241 159016 96794 42365284
Frustration tolerance decreased 23.18 11.66 43 159214 3243 42458835
Tonic clonic movements 23.07 11.66 27 159230 1340 42460738
Metastases to lung 23.04 11.66 7 159250 11417 42450661
Mood swings 23.00 11.66 79 159178 8747 42453331
Lower gastrointestinal haemorrhage 22.95 11.66 6 159251 10802 42451276
Porphyria acute 22.86 11.66 16 159241 400 42461678
Epidermolysis bullosa 22.73 11.66 11 159246 133 42461945
Hepatic cirrhosis 22.73 11.66 24 159233 19678 42442400
Patent ductus arteriosus 22.68 11.66 44 159213 3432 42458646
Hostility 22.64 11.66 21 159236 792 42461286
Diffuse large B-cell lymphoma 22.62 11.66 4 159253 9450 42452628
Poverty of speech 22.61 11.66 13 159244 228 42461850
Withdrawal catatonia 22.41 11.66 13 159244 232 42461846
Contusion 22.35 11.66 81 159176 41904 42420174
Necrotising colitis 22.30 11.66 26 159231 1285 42460793
Renal injury 22.23 11.66 9 159248 12271 42449807
Swollen tongue 22.18 11.66 28 159229 21203 42440875
Lennox-Gastaut syndrome 22.16 11.66 10 159247 102 42461976
Neglect of personal appearance 22.15 11.66 15 159242 355 42461723
Congenital nipple anomaly 22.10 11.66 6 159251 9 42462069
Cholestasis 22.10 11.66 57 159200 32822 42429256
Drug level above therapeutic 22.09 11.66 60 159197 5846 42456232
Ventricular septal defect 22.07 11.66 50 159207 4349 42457729
Micrognathia 21.88 11.66 14 159243 300 42461778
Ageusia 21.85 11.66 8 159249 11597 42450481
Brachydactyly 21.84 11.66 12 159245 192 42461886
Bicuspid aortic valve 21.80 11.66 14 159243 302 42461776
Gingival pain 21.66 11.66 3 159254 8491 42453587
Epileptic psychosis 21.61 11.66 7 159250 25 42462053
Skin lesion 21.60 11.66 43 159214 27131 42434947
Cardiac failure acute 21.60 11.66 12 159245 13621 42448457
Renal tubular necrosis 21.57 11.66 22 159235 18332 42443746
Mydriasis 21.56 11.66 77 159180 8693 42453385
Acute hepatic failure 21.56 11.66 123 159134 16950 42445128
Overweight 21.50 11.66 35 159222 2377 42459701
Skin cancer 21.41 11.66 8 159249 11454 42450624
Angina unstable 21.37 11.66 8 159249 11440 42450638
Niemann-Pick disease 21.35 11.66 6 159251 11 42462067
Neutropenic sepsis 21.27 11.66 17 159240 15929 42446149
Eye pruritus 21.26 11.66 8 159249 11404 42450674
Pain in jaw 21.25 11.66 14 159243 14488 42447590
Device issue 21.24 11.66 12 159245 13497 42448581
Basilar artery occlusion 21.21 11.66 9 159248 78 42462000
Thrombocytopenia 21.18 11.66 891 158366 189388 42272690
Scaphocephaly 21.09 11.66 8 159249 50 42462028
Incoherent 21.04 11.66 51 159206 4634 42457444
Cardiac failure chronic 21.03 11.66 5 159252 9596 42452482
Throat tightness 21.02 11.66 5 159252 9594 42452484
Pulmonary arterial hypertension 20.98 11.66 6 159251 10181 42451897
Dementia with Lewy bodies 20.97 11.66 21 159236 872 42461206
Immune reconstitution inflammatory syndrome 20.84 11.66 6 159251 10137 42451941
Skin ulcer 20.79 11.66 40 159217 25561 42436517
Auditory disorder 20.79 11.66 17 159240 540 42461538
Type 1 diabetes mellitus 20.78 11.66 56 159201 5431 42456647
Haemangioma 20.76 11.66 31 159226 1954 42460124
Aptyalism 20.76 11.66 15 159242 395 42461683
Benign prostatic hyperplasia 20.73 11.66 29 159228 21023 42441055
Substance use 20.72 11.66 29 159228 1722 42460356
Lacrimation increased 20.67 11.66 9 159248 11749 42450329
Joint hyperextension 20.66 11.66 10 159247 121 42461957
Gastric volvulus 20.63 11.66 5 159252 3 42462075
Meningomyelocele 20.50 11.66 12 159245 218 42461860
Sleep disorder 20.47 11.66 272 158985 47823 42414255
Hyperexplexia 20.43 11.66 7 159250 31 42462047
Incontinence 20.37 11.66 64 159193 6766 42455312
Hyperreflexia 20.37 11.66 43 159214 3564 42458514
Dopamine dysregulation syndrome 20.36 11.66 17 159240 556 42461522
Impaired quality of life 20.35 11.66 14 159243 14163 42447915
Treatment failure 20.33 11.66 338 158919 62286 42399792
Vagal nerve stimulator implantation 20.27 11.66 9 159248 88 42461990
Heterophoria 20.18 11.66 9 159248 89 42461989
Nocturia 20.16 11.66 10 159247 12102 42449976
Chromaturia 20.16 11.66 18 159239 15971 42446107
Suspiciousness 20.15 11.66 15 159242 414 42461664
Systemic lupus erythematosus 20.14 11.66 5 159252 9319 42452759
Oropharyngeal pain 20.09 11.66 86 159171 42424 42419654
Delusional perception 20.02 11.66 11 159246 176 42461902
Mucosal ulceration 20.00 11.66 25 159232 1329 42460749
C-reactive protein abnormal 19.93 11.66 5 159252 9256 42452822
Eosinophilic granulomatosis with polyangiitis 19.93 11.66 4 159253 8634 42453444
Dry mouth 19.90 11.66 79 159178 39800 42422278
Pulmonary hypertension 19.87 11.66 36 159221 23533 42438545
Brain stem auditory evoked response abnormal 19.82 11.66 6 159251 16 42462062
Echopraxia 19.82 11.66 6 159251 16 42462062
Simple partial seizures 19.81 11.66 15 159242 425 42461653
Decreased gait velocity 19.80 11.66 11 159246 180 42461898
Sensory integrative dysfunction 19.74 11.66 7 159250 35 42462043
Energy increased 19.68 11.66 26 159231 1461 42460617
Maternal drugs affecting foetus 19.66 11.66 44 159213 3795 42458283
Eosinophil count increased 19.59 11.66 86 159171 10677 42451401
Supernumerary nipple 19.58 11.66 7 159250 36 42462042
Kyphosis congenital 19.52 11.66 5 159252 5 42462073
Diabetic hyperosmolar coma 19.52 11.66 16 159241 510 42461568
Delayed fontanelle closure 19.42 11.66 7 159250 37 42462041
Trismus 19.42 11.66 37 159220 2847 42459231
Intestinal ischaemia 19.42 11.66 78 159179 9310 42452768
Astrocytoma, low grade 19.35 11.66 9 159248 99 42461979
IVth nerve disorder 19.31 11.66 6 159251 18 42462060
Otitis media acute 19.29 11.66 18 159239 684 42461394
Ehlers-Danlos syndrome 19.27 11.66 7 159250 38 42462040
Hepatitis C virus test positive 19.22 11.66 13 159244 307 42461771
Mental disability 19.20 11.66 8 159249 66 42462012
Rebound psychosis 19.18 11.66 11 159246 192 42461886
Foreign body aspiration 19.14 11.66 13 159244 309 42461769
Myoglobinuria 19.07 11.66 19 159238 784 42461294
Iris coloboma 19.07 11.66 6 159251 19 42462059
Aminoaciduria 18.97 11.66 12 159245 252 42461826
Abdominal compartment syndrome 18.94 11.66 22 159235 1083 42460995
Pancreatitis necrotising 18.89 11.66 42 159215 3607 42458471
Anticoagulation drug level decreased 18.88 11.66 11 159246 198 42461880
Head deformity 18.81 11.66 9 159248 106 42461972
Atrioventricular septal defect 18.80 11.66 12 159245 256 42461822
Coma blister 18.79 11.66 8 159249 70 42462008
Adverse drug reaction 18.77 11.66 74 159183 37360 42424718
Dysuria 18.61 11.66 57 159200 31039 42431039
Subacute endocarditis 18.60 11.66 8 159249 72 42462006
Gingival hypertrophy 18.58 11.66 33 159224 2406 42459672
Drug-disease interaction 18.55 11.66 20 159237 906 42461172
Injection site pruritus 18.54 11.66 6 159251 9399 42452679
Blood phosphorus increased 18.47 11.66 12 159245 12513 42449565
Nasal congestion 18.43 11.66 53 159204 29448 42432630
Condition aggravated 18.39 11.66 1169 158088 259585 42202493
Laryngeal web 18.37 11.66 4 159253 0 42462078
Ear, nose and throat examination abnormal 18.37 11.66 4 159253 0 42462078
Dentofacial anomaly 18.37 11.66 4 159253 0 42462078
Retracted nipple 18.37 11.66 4 159253 0 42462078
Mentally late developer 18.37 11.66 4 159253 0 42462078
Frontotemporal dementia 18.36 11.66 12 159245 267 42461811
Peripheral sensory neuropathy 18.35 11.66 5 159252 8757 42453321
Tendonitis 18.32 11.66 7 159250 9887 42452191
Poor feeding infant 18.31 11.66 19 159238 823 42461255
Polydipsia psychogenic 18.31 11.66 10 159247 158 42461920
Adenoidectomy 18.31 11.66 10 159247 158 42461920
Aortic stenosis 18.29 11.66 5 159252 8740 42453338
Myelocyte count increased 18.24 11.66 14 159243 405 42461673
Jaundice 18.24 11.66 67 159190 34522 42427556
Nephrotic syndrome 18.21 11.66 5 159252 8713 42453365
Tympanic membrane disorder 18.16 11.66 7 159250 46 42462032
Intestinal perforation 18.07 11.66 9 159248 10865 42451213
Acute graft versus host disease in skin 18.07 11.66 3 159254 7421 42454657
Aura 18.06 11.66 14 159243 411 42461667
Dermatitis 18.03 11.66 11 159246 11864 42450214
Acute pulmonary oedema 18.00 11.66 5 159252 8646 42453432
Compensatory sweating 17.99 11.66 6 159251 24 42462054
Movement disorder 17.98 11.66 105 159152 14593 42447485
Enteritis 17.90 11.66 9 159248 10807 42451271
Dysphagia 17.89 11.66 376 158881 72343 42389735
Dysphonia 17.86 11.66 51 159206 28399 42433679
Bradypnoea 17.82 11.66 46 159211 4347 42457731
Body dysmorphic disorder 17.77 11.66 10 159247 168 42461910
Wrist deformity 17.71 11.66 13 159244 351 42461727
Skin fissures 17.66 11.66 7 159250 9669 42452409
Cholelithiasis 17.66 11.66 38 159219 23308 42438770
Fungal infection 17.65 11.66 29 159228 19693 42442385
Cholangitis 17.64 11.66 9 159248 10718 42451360
Congenital inguinal hernia 17.56 11.66 10 159247 172 42461906
Guillain-Barre syndrome 17.53 11.66 3 159254 7260 42454818
Skin haemorrhage 17.48 11.66 4 159253 7881 42454197
Vasculitis 17.46 11.66 26 159231 18368 42443710
Craniofacial deformity 17.36 11.66 8 159249 86 42461992
Body mass index decreased 17.32 11.66 12 159245 295 42461783
Poor sucking reflex 17.30 11.66 13 159244 364 42461714
Diabetic coma 17.27 11.66 20 159237 981 42461097
Verbal abuse 17.26 11.66 11 159246 234 42461844
Blood catecholamines increased 17.26 11.66 6 159251 28 42462050
School refusal 17.26 11.66 6 159251 28 42462050
Oral candidiasis 17.24 11.66 17 159240 14388 42447690
Foetal growth restriction 17.15 11.66 51 159206 5232 42456846
Salivary gland enlargement 17.09 11.66 7 159250 55 42462023
Kidney malformation 17.06 11.66 10 159247 182 42461896
Loss of consciousness 17.06 11.66 459 158798 91895 42370183
Injection site bruising 17.05 11.66 11 159246 11514 42450564
Skin disorder 17.03 11.66 23 159234 16921 42445157
Kyphosis 17.02 11.66 23 159234 1321 42460757
Hypersexuality 16.97 11.66 26 159231 1676 42460402
Circadian rhythm sleep disorder 16.97 11.66 15 159242 531 42461547
Ammonia abnormal 16.96 11.66 8 159249 91 42461987
Anxiety disorder 16.84 11.66 28 159229 1935 42460143
Sudden death 16.73 11.66 113 159144 16516 42445562
Hypercalcaemia 16.69 11.66 26 159231 18032 42444046
Brachycephaly 16.66 11.66 8 159249 95 42461983
Gastrointestinal disorder 16.62 11.66 104 159153 46549 42415529
Tonsillitis 16.61 11.66 34 159223 2757 42459321
Syndactyly 16.60 11.66 19 159238 920 42461158
Encephalitis autoimmune 16.59 11.66 23 159234 1354 42460724
Opsoclonus myoclonus 16.59 11.66 8 159249 96 42461982
Sinus tachycardia 16.58 11.66 133 159124 20520 42441558
Hypokinesia 16.56 11.66 77 159180 9794 42452284
Embolism 16.56 11.66 6 159251 8757 42453321
Limb discomfort 16.55 11.66 14 159243 12753 42449325
Thought blocking 16.44 11.66 9 159248 143 42461935
Hypoxia 16.39 11.66 174 159083 69612 42392466
Sperm concentration decreased 16.37 11.66 10 159247 197 42461881
Acute respiratory failure 16.36 11.66 82 159175 38776 42423302
Epileptic aura 16.34 11.66 5 159252 14 42462064
Hyporeflexia 16.32 11.66 30 159227 2246 42459832
Product administration error 16.32 11.66 121 159136 18222 42443856
Metabolic encephalopathy 16.32 11.66 50 159207 5215 42456863
Therapeutic response shortened 16.21 11.66 16 159241 13538 42448540
Hyperglycinaemia 16.15 11.66 4 159253 3 42462075
Separation anxiety disorder 16.15 11.66 4 159253 3 42462075
Congenital jaw malformation 16.15 11.66 4 159253 3 42462075
Mitochondrial DNA mutation 16.15 11.66 4 159253 3 42462075
Seasonal allergy 16.13 11.66 5 159252 8050 42454028
Sinus disorder 16.11 11.66 5 159252 8045 42454033
Therapy partial responder 16.11 11.66 129 159128 19892 42442186
Proteinuria 16.10 11.66 39 159218 22944 42439134
Gastrointestinal adenocarcinoma 16.08 11.66 7 159250 65 42462013
Neonatal respiratory distress syndrome 16.04 11.66 45 159212 4468 42457610
Tachyphrenia 15.81 11.66 23 159234 1416 42460662
Iron deficiency 15.77 11.66 11 159246 11050 42451028
Anuria 15.75 11.66 12 159245 11520 42450558
Cardiovascular disorder 15.73 11.66 16 159241 13349 42448729
Gastritis 15.72 11.66 42 159215 23905 42438173
Pancreatic pseudocyst 15.69 11.66 18 159239 874 42461204
Bronchospasm 15.66 11.66 15 159242 12870 42449208
Abnormal labour affecting foetus 15.62 11.66 5 159252 17 42462061
Asthma 15.61 11.66 153 159104 62161 42399917
Gallbladder disorder 15.61 11.66 4 159253 7298 42454780
Abnormal palmar/plantar creases 15.60 11.66 10 159247 215 42461863
Pancreatic carcinoma 15.60 11.66 8 159249 9498 42452580
Haematotoxicity 15.56 11.66 11 159246 10974 42451104
Hypertriglyceridaemia 15.55 11.66 77 159180 10049 42452029
Poor personal hygiene 15.55 11.66 12 159245 350 42461728
Gastric disorder 15.54 11.66 13 159244 11909 42450169
Musculoskeletal discomfort 15.51 11.66 8 159249 9468 42452610
Hypertrophic cardiomyopathy 15.49 11.66 23 159234 1442 42460636
Clonus 15.47 11.66 38 159219 3482 42458596
Small intestinal obstruction 15.35 11.66 25 159232 17036 42445042
Pulmonary thrombosis 15.30 11.66 6 159251 8342 42453736
Sleep-related eating disorder 15.26 11.66 12 159245 360 42461718
Inappropriate schedule of product discontinuation 15.24 11.66 6 159251 42 42462036
Benign cardiac neoplasm 15.24 11.66 6 159251 42 42462036
Mixed delusion 15.24 11.66 6 159251 42 42462036
Anorgasmia 15.23 11.66 20 159237 1117 42460961
Reproductive tract hypoplasia, male 15.20 11.66 5 159252 19 42462059
Vitamin B6 decreased 15.20 11.66 5 159252 19 42462059
Gender dysphoria 15.12 11.66 6 159251 43 42462035
Feminisation acquired 15.12 11.66 6 159251 43 42462035
Ankyloglossia congenital 15.09 11.66 12 159245 366 42461712
Haematoma 14.96 11.66 54 159203 27969 42434109
Heart rate irregular 14.93 11.66 23 159234 16027 42446051
Hip fracture 14.89 11.66 17 159240 13455 42448623
Mass 14.88 11.66 7 159250 8732 42453346
Ventricular fibrillation 14.82 11.66 60 159197 30063 42432015
Gingival atrophy 14.78 11.66 6 159251 46 42462032
Blood urea decreased 14.76 11.66 22 159235 1384 42460694
Medication error 14.73 11.66 189 159068 32965 42429113
Endocarditis 14.71 11.66 6 159251 8146 42453932
Spinal fracture 14.69 11.66 8 159249 9182 42452896
Substance-induced psychotic disorder 14.67 11.66 33 159224 2856 42459222
Major depression 14.67 11.66 49 159208 5349 42456729
Colon cancer 14.66 11.66 9 159248 9672 42452406
Camptocormia 14.66 11.66 9 159248 179 42461899
Adenoidal hypertrophy 14.57 11.66 9 159248 181 42461897
Sneezing 14.57 11.66 3 159254 6360 42455718
Progressive multifocal leukoencephalopathy 14.53 11.66 13 159244 11523 42450555
Cerebral palsy 14.52 11.66 12 159245 387 42461691
Electrocardiogram T wave abnormal 14.51 11.66 25 159232 1779 42460299
Infertility male 14.48 11.66 9 159248 183 42461895
Psychomotor disadaptation syndrome 14.44 11.66 7 159250 85 42461993
Lumbosacral radiculoplexus neuropathy 14.44 11.66 7 159250 85 42461993
Gastric ulcer 14.43 11.66 29 159228 18233 42443845
Hypovolaemia 14.39 11.66 13 159244 11472 42450606
Screaming 14.39 11.66 26 159231 1921 42460157
Near drowning 14.35 11.66 4 159253 7 42462071
Refusal of treatment by patient 14.35 11.66 48 159209 5243 42456835
Gastric cancer 14.34 11.66 4 159253 6899 42455179
Liver disorder 14.32 11.66 88 159169 39556 42422522
Hyperpyrexia 14.29 11.66 37 159220 3503 42458575
Feeling of despair 14.29 11.66 20 159237 1188 42460890
Propofol infusion syndrome 14.27 11.66 20 159237 1189 42460889
CSF white blood cell count positive 14.27 11.66 5 159252 24 42462054
Severe myoclonic epilepsy of infancy 14.27 11.66 5 159252 24 42462054
Hypogammaglobulinaemia 14.27 11.66 14 159243 11877 42450201
Pulmonary vasculitis 14.25 11.66 3 159254 6263 42455815
Coagulation factor VIII level decreased 14.24 11.66 6 159251 51 42462027
Rebound effect 14.23 11.66 60 159197 7319 42454759
Joint stiffness 14.22 11.66 15 159242 12307 42449771
Staphylococcal sepsis 14.21 11.66 13 159244 11401 42450677
Rales 14.17 11.66 13 159244 11387 42450691
Escherichia infection 14.16 11.66 13 159244 11383 42450695
Poisoning deliberate 14.13 11.66 75 159182 10059 42452019
Pulmonary oedema 14.11 11.66 129 159128 53143 42408935
Haemorrhagic stroke 14.11 11.66 5 159252 7397 42454681
Coprolalia 14.10 11.66 5 159252 25 42462053
Drowning 14.04 11.66 13 159244 489 42461589
Device occlusion 14.03 11.66 7 159250 8443 42453635
Unmasking of previously unidentified disease 14.02 11.66 20 159237 1209 42460869
Intermittent explosive disorder 14.01 11.66 4 159253 8 42462070
Intervertebral disc degeneration 14 11.66 5 159252 7362 42454716
Hallucinations, mixed 13.97 11.66 36 159221 3399 42458679
Spinal pain 13.96 11.66 4 159253 6778 42455300
Madarosis 13.96 11.66 13 159244 493 42461585
Wrong schedule 13.87 11.66 11 159246 334 42461744
Blood urine present 13.86 11.66 14 159243 11719 42450359
Hypomagnesaemia 13.85 11.66 57 159200 28431 42433647
Blood pressure diastolic abnormal 13.80 11.66 3 159254 6125 42455953
Congenital cerebral cyst 13.79 11.66 5 159252 27 42462051
Red blood cell sedimentation rate decreased 13.78 11.66 10 159247 265 42461813
Blindness congenital 13.78 11.66 3 159254 0 42462078
Acquired epileptic aphasia 13.78 11.66 3 159254 0 42462078
Antipsychotic drug level 13.78 11.66 3 159254 0 42462078
Deformity of orbit 13.78 11.66 3 159254 0 42462078
Pyruvate carboxylase deficiency 13.78 11.66 3 159254 0 42462078
Transgenerational epigenetic inheritance 13.78 11.66 3 159254 0 42462078
Neonatal hypoacusis 13.78 11.66 3 159254 0 42462078
Hypocarnitinaemia 13.78 11.66 3 159254 0 42462078
Congenital tongue anomaly 13.78 11.66 3 159254 0 42462078
Red blood cell nucleated morphology present 13.78 11.66 3 159254 0 42462078
Blood osmolarity increased 13.74 11.66 12 159245 418 42461660
Hepatitis B 13.74 11.66 4 159253 6707 42455371
Lordosis 13.71 11.66 11 159246 340 42461738
Wound 13.68 11.66 27 159230 17090 42444988
Hand-eye coordination impaired 13.67 11.66 6 159251 57 42462021
Abscess 13.66 11.66 20 159237 14228 42447850
Conjunctival hyperaemia 13.66 11.66 34 159223 3142 42458936
Lacrimal gland enlargement 13.64 11.66 5 159252 28 42462050
Lip swelling 13.61 11.66 32 159225 19021 42443057
Dysphemia 13.55 11.66 25 159232 1877 42460201
Upper respiratory tract infection 13.53 11.66 97 159160 42076 42420002
Joint range of motion decreased 13.52 11.66 6 159251 7747 42454331
Neutropenia 13.48 11.66 891 158366 198540 42263538
Dermatitis acneiform 13.48 11.66 6 159251 7733 42454345
Hypertensive crisis 13.46 11.66 11 159246 10195 42451883
Food craving 13.42 11.66 13 159244 518 42461560
Oropharyngeal discomfort 13.42 11.66 40 159217 4109 42457969
Heparin-induced thrombocytopenia 13.38 11.66 4 159253 6593 42455485
Electrocardiogram QRS complex prolonged 13.36 11.66 50 159207 5773 42456305
Myocardial ischaemia 13.36 11.66 29 159228 17733 42444345
Feeding disorder 13.35 11.66 65 159192 8426 42453652
Acute graft versus host disease 13.35 11.66 7 159250 8208 42453870
Rotator cuff syndrome 13.34 11.66 4 159253 6582 42455496
Reduced facial expression 13.33 11.66 22 159235 1511 42460567
Mouth breathing 13.32 11.66 7 159250 102 42461976
Mitochondrial cytopathy 13.30 11.66 8 159249 153 42461925
Poor quality sleep 13.25 11.66 70 159187 9370 42452708
Accidental death 13.25 11.66 33 159224 3050 42459028
Intracranial pressure increased 13.21 11.66 43 159214 4631 42457447
Myositis 13.18 11.66 22 159235 14844 42447234
Device malfunction 13.15 11.66 16 159241 12311 42449767
Ischaemic cardiomyopathy 13.14 11.66 4 159253 6518 42455560
Coronary artery occlusion 13.13 11.66 13 159244 10984 42451094
Hydronephrosis 13.08 11.66 15 159242 11850 42450228
Facial bones fracture 13.04 11.66 28 159229 2348 42459730
Saccadic eye movement 13.03 11.66 8 159249 159 42461919
Skin irritation 13.00 11.66 6 159251 7568 42454510
Haemorrhage intracranial 12.99 11.66 28 159229 17164 42444914
Oxygen saturation decreased 12.98 11.66 167 159090 64520 42397558
Flank pain 12.96 11.66 6 159251 7557 42454521
Diffusion-weighted brain MRI abnormal 12.95 11.66 5 159252 33 42462045
Hyperbilirubinaemia 12.94 11.66 37 159220 20598 42441480
Testicular operation 12.87 11.66 4 159253 12 42462066
Locomotive syndrome 12.87 11.66 4 159253 12 42462066
Therapeutic hypothermia 12.87 11.66 4 159253 12 42462066
Monorchidism 12.87 11.66 4 159253 12 42462066
Metamyelocyte count increased 12.86 11.66 12 159245 456 42461622
Lung opacity 12.86 11.66 3 159254 5834 42456244
Cerebral cyst 12.86 11.66 10 159247 295 42461783
Limb asymmetry 12.85 11.66 7 159250 110 42461968
Conversion disorder 12.84 11.66 13 159244 547 42461531
Pyromania 12.82 11.66 5 159252 34 42462044
Back disorder 12.82 11.66 6 159251 7508 42454570
Eye irritation 12.82 11.66 14 159243 11304 42450774
Troponin increased 12.80 11.66 118 159139 18944 42443134
Spinal stenosis 12.78 11.66 4 159253 6402 42455676
Sarcopenia 12.63 11.66 16 159241 862 42461216
Cholinergic syndrome 12.59 11.66 14 159243 657 42461421
Hyperventilation 12.58 11.66 33 159224 3149 42458929
Acute psychosis 12.58 11.66 26 159231 2123 42459955
Lymphopenia 12.57 11.66 40 159217 21523 42440555
Drug level fluctuating 12.54 11.66 14 159243 660 42461418
Macrocephaly 12.46 11.66 12 159245 475 42461603
Dependent personality disorder 12.44 11.66 6 159251 72 42462006
Therapeutic response changed 12.44 11.66 13 159244 568 42461510
Blood sodium increased 12.34 11.66 33 159224 3185 42458893
Autoimmune haemolytic anaemia 12.33 11.66 3 159254 5668 42456410
Product dose omission in error 12.33 11.66 8 159249 8346 42453732
Anodontia 12.30 11.66 6 159251 74 42462004
Cystitis haemorrhagic 12.28 11.66 6 159251 7323 42454755
Hyperlactacidaemia 12.28 11.66 41 159216 4475 42457603
Surgery 12.25 11.66 30 159227 17586 42444492
Lung neoplasm malignant 12.25 11.66 34 159223 19113 42442965
Autoimmune hepatitis 12.24 11.66 3 159254 5642 42456436
Persistent depressive disorder 12.21 11.66 12 159245 487 42461591
Miosis 12.14 11.66 89 159168 13357 42448721
Illusion 12.12 11.66 17 159240 1012 42461066
Gastrointestinal infection 12.11 11.66 5 159252 6738 42455340
Slow speech 12.10 11.66 23 159234 1767 42460311
Congenital aortic anomaly 12.09 11.66 6 159251 77 42462001
Somnambulism 12.08 11.66 34 159223 3381 42458697
Sputum discoloured 12.07 11.66 12 159245 10120 42451958
Fanconi syndrome acquired 12.07 11.66 25 159232 2045 42460033
Lip haemorrhage 12.04 11.66 16 159241 904 42461174
Irregular sleep phase 12.01 11.66 7 159250 126 42461952
Post-anoxic myoclonus 12.00 11.66 4 159253 16 42462062
Intention tremor 11.99 11.66 12 159245 498 42461580
Pseudomonas infection 11.98 11.66 26 159231 15897 42446181
Adenocarcinoma of appendix 11.96 11.66 7 159250 127 42461951
Hyperphagia 11.96 11.66 22 159235 1648 42460430
Pulmonary valve incompetence 11.93 11.66 18 159239 1145 42460933
Blood pressure decreased 11.92 11.66 150 159107 58182 42403896
Product administered to patient of inappropriate age 11.87 11.66 42 159215 4719 42457359
Blood pressure systolic abnormal 11.87 11.66 3 159254 5525 42456553
Wrong technique in product usage process 11.84 11.66 102 159155 42533 42419545
Phimosis 11.83 11.66 18 159239 1153 42460925
Congenital cardiovascular anomaly 11.82 11.66 8 159249 189 42461889
Clostridium test positive 11.80 11.66 3 159254 5502 42456576
Haematuria traumatic 11.78 11.66 10 159247 335 42461743
Food aversion 11.77 11.66 12 159245 509 42461569
Prostate cancer metastatic 11.77 11.66 5 159252 6624 42455454
Neurological decompensation 11.76 11.66 36 159221 3753 42458325
Apnoea 11.75 11.66 59 159198 7744 42454334
Injection site haemorrhage 11.72 11.66 16 159241 11720 42450358
Intestinal obstruction 11.72 11.66 154 159103 27004 42435074
Pica 11.72 11.66 5 159252 44 42462034
Urine output decreased 11.71 11.66 14 159243 10859 42451219
Dacryoadenitis acquired 11.71 11.66 3 159254 3 42462075
Nasopharyngeal reflux 11.71 11.66 3 159254 3 42462075
Urine cannabinoids increased 11.71 11.66 3 159254 3 42462075
CSWS syndrome 11.71 11.66 3 159254 3 42462075
Kluver-Bucy syndrome 11.71 11.66 3 159254 3 42462075
Use of accessory respiratory muscles 11.68 11.66 12 159245 514 42461564

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 3525.25 11.04 3310 241180 217875 110126934
Drug interaction 3393.96 11.04 4809 239681 495374 109849435
Hyperammonaemia 2997.17 11.04 1132 243358 12600 110332209
Hyperammonaemic encephalopathy 2314.12 11.04 738 243752 4696 110340113
Status epilepticus 1939.18 11.04 1076 243414 30495 110314314
Somnolence 1785.38 11.04 2704 241786 294745 110050064
Aggression 1667.97 11.04 1234 243256 57976 110286833
Neuroleptic malignant syndrome 1611.76 11.04 980 243510 33079 110311730
Multiple-drug resistance 1407.97 11.04 654 243836 12581 110332228
Toxicity to various agents 1312.29 11.04 3120 241370 477435 109867374
Psychotic disorder 1302.42 11.04 1002 243488 49935 110294874
Sopor 1286.83 11.04 873 243617 35673 110309136
Extrapyramidal disorder 1125.95 11.04 735 243755 28132 110316677
Generalised tonic-clonic seizure 1083.61 11.04 927 243563 53753 110291056
Coma 989.90 11.04 1261 243229 116608 110228201
Agitation 915.63 11.04 1188 243302 111863 110232946
Intentional overdose 887.77 11.04 1270 243220 131231 110213578
Arthralgia 877.31 11.04 315 244175 779317 109565492
Mania 871.44 11.04 554 243936 20242 110324567
Parkinsonism 848.36 11.04 558 243932 21629 110323180
Overdose 838.97 11.04 1696 242794 232098 110112711
Ammonia increased 810.69 11.04 386 244104 7864 110336945
Sedation 798.18 11.04 874 243616 68809 110276000
Petit mal epilepsy 756.56 11.04 358 244132 7189 110337620
Epilepsy 749.65 11.04 1013 243477 99196 110245613
Schizophrenia 741.25 11.04 510 243980 21316 110323493
Salivary hypersecretion 722.25 11.04 461 244029 16960 110327849
Granulocytopenia 717.22 11.04 410 244080 12305 110332504
Abnormal behaviour 699.30 11.04 625 243865 38414 110306395
Ataxia 689.11 11.04 555 243935 29553 110315256
Tremor 680.52 11.04 1429 243061 200803 110144006
Joint swelling 675.85 11.04 90 244400 442755 109902054
Pain 659.36 11.04 685 243805 954270 109390539
Dyspnoea 644.75 11.04 907 243583 1105965 109238844
Intentional self-injury 640.46 11.04 584 243906 36845 110307964
Depressed level of consciousness 637.23 11.04 996 243494 111282 110233527
Drug level increased 632.54 11.04 647 243843 47072 110297737
Suicide attempt 625.86 11.04 945 243545 102449 110242360
Infusion related reaction 617.53 11.04 63 244427 381099 109963710
Irritability 611.66 11.04 636 243854 47173 110297636
Drug ineffective 605.76 11.04 5553 238937 1514987 108829822
Synovitis 587.78 11.04 3 244487 274089 110070720
Rheumatoid arthritis 569.75 11.04 21 244469 299592 110045217
Drug reaction with eosinophilia and systemic symptoms 568.99 11.04 800 243690 81295 110263514
Treatment noncompliance 547.53 11.04 739 243751 72251 110272558
Drug abuse 536.59 11.04 1201 243289 176210 110168599
Arthropathy 520.98 11.04 28 244462 287494 110057315
Anticonvulsant drug level increased 514.70 11.04 205 244285 2653 110342156
Psychomotor hyperactivity 509.62 11.04 395 244095 19882 110324927
Suicidal ideation 502.24 11.04 811 243679 93126 110251683
Hallucination, auditory 493.44 11.04 433 244057 25964 110318845
Altered state of consciousness 484.24 11.04 617 243873 57009 110287800
Catatonia 483.30 11.04 305 244185 10995 110333814
Antipsychotic drug level increased 480.20 11.04 257 244233 6758 110338051
Encephalopathy 477.97 11.04 732 243758 80323 110264486
Delusion 473.04 11.04 404 244086 23351 110321458
Peripheral swelling 467.88 11.04 155 244335 403879 109940930
Diarrhoea 458.74 11.04 1166 243324 1138339 109206470
Cognitive disorder 454.90 11.04 746 243744 86765 110258044
Psychomotor skills impaired 448.14 11.04 246 244244 6812 110337997
Pemphigus 447.06 11.04 5 244485 214565 110130244
Swelling 440.50 11.04 116 244374 350925 109993884
Fatigue 429.67 11.04 1325 243165 1214633 109130176
Abdominal discomfort 425.68 11.04 169 244321 393689 109951120
Systemic lupus erythematosus 425.17 11.04 37 244453 254301 110090508
Blood creatine phosphokinase increased 423.91 11.04 655 243835 72422 110272387
Pneumonia aspiration 420.23 11.04 691 243799 80542 110264267
Completed suicide 414.39 11.04 1328 243162 241053 110103756
Drug resistance 409.48 11.04 562 243928 55812 110288997
Partial seizures 406.25 11.04 274 244216 11075 110333734
Myoclonic epilepsy 405.94 11.04 170 244320 2521 110342288
Sinusitis 404.09 11.04 82 244408 296606 110048203
Glossodynia 394.82 11.04 24 244466 221980 110122829
Foetal anticonvulsant syndrome 393.04 11.04 96 244394 172 110344637
Nasopharyngitis 387.26 11.04 194 244296 394167 109950642
Paranoia 382.53 11.04 349 244141 22025 110322784
Hypersensitivity 375.78 11.04 213 244277 403785 109941024
Duodenal ulcer perforation 370.82 11.04 4 244486 177696 110167113
Muscle rigidity 370.71 11.04 354 244136 23677 110321132
Anticonvulsant drug level decreased 370.06 11.04 149 244341 1987 110342822
Disorientation 366.67 11.04 602 243888 70069 110274740
Hypomania 364.27 11.04 246 244244 9964 110334845
Akathisia 363.30 11.04 302 244188 16811 110327998
Pain in extremity 361.32 11.04 327 244163 486791 109858018
Helicobacter infection 355.47 11.04 10 244480 181867 110162942
Febrile neutropenia 353.75 11.04 129 244361 316638 110028171
Pruritus 353.27 11.04 461 244029 581099 109763710
Electroencephalogram abnormal 345.31 11.04 198 244292 5975 110338834
Fanconi syndrome 343.76 11.04 164 244326 3355 110341454
Hypernatraemia 338.27 11.04 295 244195 17538 110327271
Drug level decreased 336.17 11.04 299 244191 18249 110326560
Anticonvulsant drug level above therapeutic 334.19 11.04 120 244370 1142 110343667
Myocarditis 330.25 11.04 369 244121 29686 110315123
Dysarthria 329.95 11.04 634 243856 83487 110261322
Hypothermia 329.39 11.04 346 244144 25956 110318853
Folliculitis 328.45 11.04 9 244481 167644 110177165
Psoriatic arthropathy 327.80 11.04 29 244461 196732 110148077
Behaviour disorder 326.54 11.04 225 244265 9422 110335387
Psychomotor retardation 324.96 11.04 207 244283 7585 110337224
Wrong patient received product 323.20 11.04 195 244295 6479 110338330
Intellectual disability 318.71 11.04 131 244359 1848 110342961
Tardive dyskinesia 318.53 11.04 254 244236 13325 110331484
Mental disorder 312.78 11.04 407 244083 38384 110306425
Psychiatric decompensation 309.41 11.04 180 244310 5585 110339224
Myoclonus 307.16 11.04 372 244118 32626 110312183
Dysmorphism 302.64 11.04 95 244395 569 110344240
Drug ineffective for unapproved indication 298.28 11.04 685 243805 102153 110242656
Wound 294.87 11.04 77 244413 234360 110110449
Stomatitis 293.44 11.04 115 244375 270127 110074682
Headache 293.22 11.04 987 243503 881390 109463419
Osteoarthritis 288.38 11.04 33 244457 182590 110162219
Schizoaffective disorder 284.72 11.04 139 244351 2997 110341812
Delirium 283.73 11.04 796 243694 134229 110210580
Impaired healing 281.42 11.04 48 244442 196669 110148140
Mental impairment 274.95 11.04 293 244197 22346 110322463
Dystonia 273.60 11.04 311 244179 25494 110319315
Cerebral atrophy 272.95 11.04 197 244293 8888 110335921
Disturbance in attention 271.57 11.04 490 244000 61505 110283304
Irritable bowel syndrome 268.73 11.04 26 244464 164189 110180620
Hypoaesthesia 268.10 11.04 183 244307 314040 110030769
Urticaria 267.68 11.04 189 244301 318668 110026141
Abdominal pain upper 267.62 11.04 227 244263 348884 109995925
Discomfort 267.22 11.04 72 244418 214635 110130174
Fibromyalgia 267.09 11.04 32 244458 170877 110173932
Dyskinesia 266.52 11.04 438 244052 51008 110293801
Electrocardiogram QT prolonged 265.92 11.04 679 243811 108281 110236528
Nausea 265.24 11.04 1625 242865 1234065 109110744
Stevens-Johnson syndrome 260.29 11.04 412 244078 46489 110298320
Drug withdrawal convulsions 257.26 11.04 120 244370 2329 110342480
Speech disorder 256.26 11.04 476 244014 61093 110283716
Sudden unexplained death in epilepsy 251.29 11.04 87 244403 736 110344073
Bradyphrenia 251.10 11.04 208 244282 11520 110333289
Muscle injury 247.98 11.04 16 244474 140791 110204018
Toxic encephalopathy 247.82 11.04 231 244259 14983 110329826
Cerebellar atrophy 247.05 11.04 100 244390 1353 110343456
Mental status changes 240.85 11.04 525 243965 75597 110269212
Tonic convulsion 240.01 11.04 123 244367 2951 110341858
Joint range of motion decreased 236.94 11.04 7 244483 121825 110222984
C-reactive protein abnormal 236.80 11.04 12 244478 129683 110215126
Developmental delay 236.01 11.04 97 244393 1368 110343441
Cough 235.62 11.04 412 244078 461229 109883580
Focal dyscognitive seizures 232.97 11.04 130 244360 3719 110341090
Bipolar disorder 231.86 11.04 178 244312 8829 110335980
Bursitis 231.08 11.04 14 244476 129904 110214905
Depressive symptom 227.00 11.04 171 244319 8243 110336566
Arthritis 226.67 11.04 47 244443 167539 110177270
Alopecia 226.57 11.04 284 244206 364469 109980340
Foetal exposure during pregnancy 226.06 11.04 163 244327 7342 110337467
Nystagmus 224.60 11.04 194 244296 11383 110333426
Anticonvulsant drug level below therapeutic 222.03 11.04 87 244403 1075 110343734
Chest pain 219.55 11.04 307 244183 376068 109968741
Rhabdomyolysis 217.77 11.04 673 243817 119728 110225081
Thrombocytopenia 216.99 11.04 1417 243073 347468 109997341
Inflammation 216.82 11.04 78 244412 193160 110151649
Pericarditis 214.62 11.04 108 244382 219006 110125803
Musculoskeletal pain 213.81 11.04 69 244421 182954 110161855
Eosinophilic pleural effusion 213.66 11.04 69 244421 459 110344350
Drug intolerance 213.65 11.04 356 244134 406156 109938653
Restlessness 213.24 11.04 418 244072 55841 110288968
Paradoxical drug reaction 209.95 11.04 174 244316 9643 110335166
Persecutory delusion 208.86 11.04 145 244345 6146 110338663
Contraindicated product administered 208.54 11.04 147 244343 248120 110096689
Leukopenia 206.61 11.04 761 243729 148030 110196779
Night sweats 204.69 11.04 27 244463 133956 110210853
Atonic seizures 198.20 11.04 80 244410 1074 110343735
Pancreatitis acute 196.73 11.04 421 244069 59853 110284956
Mobility decreased 196.24 11.04 143 244347 237279 110107530
Gastrointestinal disorder 194.49 11.04 150 244340 241802 110103007
Drug hypersensitivity 193.45 11.04 450 244040 453640 109891169
Antipsychotic drug level below therapeutic 191.55 11.04 88 244402 1647 110343162
Hepatic function abnormal 191.06 11.04 530 243960 88765 110256044
Psychogenic seizure 188.67 11.04 96 244394 2268 110342541
Depression 188.31 11.04 1274 243216 316061 110028748
Therapeutic product effect decreased 186.99 11.04 159 244331 244157 110100652
Neuropathy peripheral 182.22 11.04 84 244406 179193 110165616
Seizure cluster 179.25 11.04 68 244422 765 110344044
Lung disorder 177.43 11.04 88 244402 179959 110164850
Lower respiratory tract infection 176.71 11.04 166 244324 242940 110101869
Lethargy 175.69 11.04 530 243960 93046 110251763
Back pain 175.16 11.04 347 244143 370649 109974160
Ill-defined disorder 173.10 11.04 65 244425 156788 110188021
Oculogyric crisis 172.85 11.04 107 244383 3725 110341084
Peripheral venous disease 170.65 11.04 3 244487 84114 110260695
Carnitine deficiency 170.14 11.04 51 244439 255 110344554
Anaemia 169.93 11.04 629 243861 546457 109798352
Stupor 169.52 11.04 143 244347 8122 110336687
Euphoric mood 169.38 11.04 147 244343 8680 110336129
Speech disorder developmental 165.77 11.04 66 244424 853 110343956
Contusion 163.07 11.04 165 244325 233196 110111613
Rash 162.19 11.04 1106 243384 819858 109524951
Blood prolactin increased 161.20 11.04 110 244380 4532 110340277
Pulmonary fibrosis 159.67 11.04 19 244471 102023 110242786
Serotonin syndrome 158.39 11.04 382 244108 58771 110286038
Respiratory depression 157.11 11.04 266 244224 31735 110313074
Injection site pain 156.57 11.04 100 244390 177822 110166987
Wound infection 155.91 11.04 16 244474 96449 110248360
Loss of consciousness 155.73 11.04 850 243640 195456 110149353
Priapism 155.64 11.04 118 244372 5743 110339066
Malignant neoplasm progression 155.15 11.04 97 244393 174470 110170339
Intentional product use issue 154.94 11.04 192 244298 247714 110097095
Depression suicidal 152.72 11.04 108 244382 4716 110340093
Hypotonia 152.25 11.04 181 244309 15564 110329245
Asthma 152.11 11.04 198 244292 250093 110094716
Hyperprolactinaemia 152.10 11.04 122 244368 6453 110338356
Psychotic symptom 152.05 11.04 99 244391 3768 110341041
Brain oedema 152.02 11.04 258 244232 30840 110313969
Lip dry 150.89 11.04 21 244469 100062 110244747
Malaise 149.64 11.04 872 243618 670947 109673862
Muscle spasms 148.48 11.04 241 244249 277916 110066893
Paraesthesia 148.15 11.04 239 244251 276282 110068527
Metabolic acidosis 146.79 11.04 520 243970 99224 110245585
Autism spectrum disorder 146.48 11.04 76 244414 1872 110342937
Impulsive behaviour 145.58 11.04 91 244399 3224 110341585
Disinhibition 145.16 11.04 89 244401 3045 110341764
Wheezing 144.98 11.04 212 244278 255018 110089791
Cardiac failure congestive 142.56 11.04 78 244412 150922 110193887
Dry mouth 141.26 11.04 140 244350 199808 110145001
Asthenia 140.61 11.04 919 243571 688080 109656729
Neutropenia 139.85 11.04 1353 243137 373267 109971542
Eosinophilia 139.19 11.04 359 244131 57577 110287232
General physical health deterioration 138.62 11.04 479 244011 424816 109919993
Tearfulness 137.57 11.04 121 244369 7274 110337535
Bradykinesia 137.00 11.04 143 244347 10645 110334164
Hyponatraemia 135.78 11.04 885 243605 216768 110128041
Obsessive-compulsive disorder 135.75 11.04 119 244371 7122 110337687
Infection 135.64 11.04 383 244107 361817 109982992
Hallucination, visual 134.30 11.04 281 244209 39324 110305485
Grip strength decreased 132.99 11.04 12 244478 80162 110264647
Abdominal pain 132.50 11.04 633 243857 512356 109832453
COVID-19 132.03 11.04 211 244279 244849 110099960
Asterixis 131.95 11.04 84 244406 3074 110341735
Hypertonia 131.86 11.04 125 244365 8281 110336528
Musculoskeletal stiffness 130.93 11.04 263 244227 279559 110065250
Bipolar I disorder 129.76 11.04 74 244416 2209 110342600
Psychiatric symptom 129.51 11.04 129 244361 9084 110335725
Injury 128.85 11.04 121 244369 177144 110167665
Neutrophil count increased 128.33 11.04 255 244235 34397 110310412
Antipsychotic drug level above therapeutic 127.82 11.04 75 244415 2365 110342444
Drug level below therapeutic 127.68 11.04 143 244347 11530 110333279
Anger 126.85 11.04 182 244308 18825 110325984
Cytokine release syndrome 126.78 11.04 7 244483 70299 110274510
Blister 126.09 11.04 192 244298 227184 110117625
Tachycardia 125.56 11.04 895 243595 225750 110119059
Atrial fibrillation 125.35 11.04 196 244294 229446 110115363
Learning disorder 125.27 11.04 51 244439 701 110344108
Nephrogenic diabetes insipidus 125.05 11.04 74 244416 2371 110342438
Sciatica 124.74 11.04 26 244464 92373 110252436
Fluid retention 124.34 11.04 28 244462 94279 110250530
Thinking abnormal 123.82 11.04 160 244330 14980 110329829
Pleurothotonus 123.58 11.04 74 244416 2424 110342385
Antipsychotic drug level decreased 123.45 11.04 61 244429 1351 110343458
Knee arthroplasty 121.84 11.04 5 244485 64943 110279866
Thrombosis 121.62 11.04 44 244446 108618 110236191
Drooling 121.32 11.04 111 244379 7028 110337781
Unresponsive to stimuli 119.44 11.04 361 244129 63429 110281380
Infantile spasms 118.10 11.04 41 244449 350 110344459
Confusional state 117.50 11.04 1566 242924 467114 109877695
Gaze palsy 116.57 11.04 80 244410 3327 110341482
Taste disorder 116.40 11.04 7 244483 65380 110279429
Herpes zoster 116.12 11.04 47 244443 108332 110236477
Propofol infusion syndrome 116.04 11.04 72 244418 2517 110342292
Partial seizures with secondary generalisation 115.44 11.04 50 244440 809 110344000
Product substitution issue 114.95 11.04 193 244297 22868 110321941
Disease progression 114.47 11.04 229 244261 243805 110101004
Increased appetite 112.79 11.04 152 244338 14825 110329984
Blood cholesterol increased 112.44 11.04 146 244344 184639 110160170
Acute hepatic failure 111.34 11.04 248 244242 36220 110308589
Differential white blood cell count abnormal 111.28 11.04 67 244423 2217 110342592
Interstitial lung disease 111.14 11.04 87 244403 139247 110205562
Oedema 111.03 11.04 183 244307 209793 110135016
Change in seizure presentation 110.30 11.04 48 244442 786 110344023
Communication disorder 109.19 11.04 90 244400 4949 110339860
Total lung capacity increased 108.05 11.04 90 244400 5022 110339787
Maternal exposure during pregnancy 106.50 11.04 255 244235 254628 110090181
Dyspnoea exertional 105.34 11.04 49 244441 104011 110240798
White blood cell count increased 104.50 11.04 458 244032 96384 110248425
Rhinorrhoea 104.46 11.04 48 244442 102618 110242191
Blood pressure increased 104.42 11.04 263 244227 258110 110086699
Apathy 103.28 11.04 152 244338 16087 110328722
Injection site reaction 103.25 11.04 34 244456 89036 110255773
Acidosis hyperchloraemic 102.68 11.04 56 244434 1530 110343279
Hypertension 102.62 11.04 683 243807 509401 109835408
Psoriasis 102.39 11.04 95 244395 139898 110204911
Hallucination 101.43 11.04 469 244021 100963 110243846
Mucosal inflammation 100.89 11.04 43 244447 96098 110248711
Plasma cell myeloma 100.26 11.04 11 244479 62925 110281884
Homicidal ideation 98.48 11.04 74 244416 3553 110341256
Influenza 98.43 11.04 138 244352 168963 110175846
Gastrointestinal haemorrhage 98.43 11.04 133 244357 165385 110179424
Dry skin 98.18 11.04 58 244432 107595 110237214
Chest discomfort 98.11 11.04 145 244345 173703 110171106
Autoimmune disorder 98.10 11.04 14 244476 65469 110279340
Medication overuse headache 97.91 11.04 54 244436 1509 110343300
Injection site erythema 97.44 11.04 43 244447 94133 110250676
Product residue present 97.33 11.04 76 244414 3865 110340944
Cogwheel rigidity 97.20 11.04 74 244416 3624 110341185
Magnetic resonance imaging head abnormal 95.71 11.04 72 244418 3463 110341346
Posture abnormal 95.61 11.04 79 244411 4359 110340450
Hyperthermia 95.52 11.04 170 244320 21102 110323707
Enuresis 94.75 11.04 76 244414 4020 110340789
Drug withdrawal syndrome 94.72 11.04 239 244251 37815 110306994
Sleep disorder due to a general medical condition 94.55 11.04 5 244485 52107 110292702
Dysphoria 94.06 11.04 92 244398 6336 110338473
Dyspepsia 93.19 11.04 175 244315 190790 110154019
Inappropriate antidiuretic hormone secretion 93.19 11.04 221 244269 33630 110311179
Resting tremor 93.00 11.04 54 244436 1669 110343140
Oppositional defiant disorder 92.74 11.04 37 244453 481 110344328
Poisoning 92.33 11.04 201 244289 28904 110315905
Toxic epidermal necrolysis 91.53 11.04 305 244185 56422 110288387
Asthma-chronic obstructive pulmonary disease overlap syndrome 91.34 11.04 90 244400 6254 110338555
Hallucinations, mixed 90.84 11.04 104 244386 8589 110336220
Metabolic encephalopathy 90.63 11.04 117 244373 10943 110333866
Feeling hot 90.54 11.04 44 244446 91062 110253747
Lower limb fracture 90.49 11.04 27 244463 75321 110269488
Depressed mood 89.43 11.04 317 244173 60492 110284317
Myocardial infarction 89.42 11.04 181 244309 191902 110152907
Bone erosion 88.94 11.04 3 244487 46368 110298441
Myelosuppression 88.65 11.04 49 244441 94291 110250518
Myalgia 88.59 11.04 228 244262 222153 110122656
Retinogram abnormal 88.47 11.04 33 244457 353 110344456
Rectal haemorrhage 86.83 11.04 82 244408 119751 110225058
Bronchitis 86.65 11.04 133 244357 156899 110187910
Gait disturbance 86.32 11.04 968 243522 277240 110067569
Erythema 85.89 11.04 342 244148 291105 110053704
Hip arthroplasty 85.83 11.04 11 244479 55802 110289007
Anaphylactic reaction 85.45 11.04 76 244414 114224 110230585
Necrosis ischaemic 85.26 11.04 47 244443 1312 110343497
Pancreatitis 85.19 11.04 421 244069 93112 110251697
Urinary incontinence 84.50 11.04 268 244222 48319 110296490
Hyperkinesia 84.32 11.04 64 244426 3120 110341689
Pressure of speech 83.39 11.04 46 244444 1286 110343523
Chills 83.36 11.04 186 244304 190394 110154415
Nail disorder 83.12 11.04 14 244476 57921 110286888
Hyperlactacidaemia 83.01 11.04 97 244393 8189 110336620
Blood lactic acid increased 82.33 11.04 135 244355 15686 110329123
Neovascularisation 82.17 11.04 50 244440 1687 110343122
Logorrhoea 82.15 11.04 76 244414 4881 110339928
Mitochondrial DNA mutation 81.76 11.04 33 244457 443 110344366
Encephalitis autoimmune 80.63 11.04 65 244425 3463 110341346
Leukocytosis 80.36 11.04 282 244208 53546 110291263
Mood altered 79.99 11.04 158 244332 21217 110323592
Hypercholesterolaemia 79.97 11.04 51 244439 90786 110254023
Blood pressure systolic increased 79.59 11.04 42 244448 82949 110261860
Haematochezia 79.17 11.04 83 244407 115441 110229368
Affect lability 78.67 11.04 145 244345 18492 110326317
Acute kidney injury 77.44 11.04 966 243524 634464 109710345
Sexually inappropriate behaviour 77.12 11.04 35 244455 636 110344173
Chorea 76.91 11.04 61 244429 3174 110341635
Eosinophil count decreased 76.83 11.04 80 244410 5938 110338871
Postictal paralysis 76.50 11.04 34 244456 587 110344222
Red blood cell sedimentation rate increased 76.02 11.04 39 244451 78263 110266546
Dysmetria 75.92 11.04 44 244446 1355 110343454
Decreased eye contact 75.48 11.04 38 244452 877 110343932
Delusion of grandeur 74.81 11.04 52 244438 2208 110342601
Physical assault 74.81 11.04 46 244444 1582 110343227
Hepatic cirrhosis 74.63 11.04 28 244462 67598 110277211
Diabetes insipidus 74.46 11.04 82 244408 6488 110338321
Hirsutism 73.92 11.04 47 244443 1716 110343093
Withdrawal syndrome 73.88 11.04 193 244297 31187 110313622
Death 73.46 11.04 1095 243395 697774 109647035
Choreoathetosis 73.03 11.04 46 244444 1652 110343157
Gingival hypertrophy 72.93 11.04 67 244423 4264 110340545
Affective disorder 72.62 11.04 106 244384 11135 110333674
Grandiosity 72.29 11.04 32 244458 547 110344262
Carnitine decreased 71.72 11.04 15 244475 6 110344803
Frequent bowel movements 71.67 11.04 34 244456 71356 110273453
Learning disability 71.49 11.04 24 244466 183 110344626
Mydriasis 71.41 11.04 154 244336 22003 110322806
Erectile dysfunction 70.45 11.04 138 244352 18418 110326391
Nasal congestion 70.33 11.04 68 244422 98214 110246595
Onychomadesis 70.21 11.04 9 244481 45654 110299155
Colitis ulcerative 70.09 11.04 42 244448 77321 110267488
Jaundice cholestatic 69.82 11.04 120 244370 14488 110330321
Gait inability 69.19 11.04 122 244368 136254 110208555
Attention deficit hyperactivity disorder 68.95 11.04 66 244424 4425 110340384
Self-injurious ideation 68.88 11.04 65 244425 4281 110340528
Autonomic nervous system imbalance 68.75 11.04 74 244416 5706 110339103
Bradypnoea 68.54 11.04 90 244400 8559 110336250
Throat irritation 68.42 11.04 17 244473 53535 110291274
Type 2 diabetes mellitus 68.08 11.04 185 244305 177047 110167762
Craniosynostosis 67.61 11.04 19 244471 72 110344737
Joint stiffness 67.54 11.04 32 244458 67211 110277598
Drug level changed 67.05 11.04 31 244459 589 110344220
Hot flush 66.98 11.04 31 244459 66005 110278804
Muscular weakness 66.17 11.04 303 244187 248165 110096644
Epistaxis 65.80 11.04 117 244373 130255 110214554
Lennox-Gastaut syndrome 65.53 11.04 25 244465 286 110344523
Coordination abnormal 65.47 11.04 161 244329 25067 110319742
Choking 64.33 11.04 118 244372 14992 110329817
Injection site pruritus 64.09 11.04 17 244473 51241 110293568
Intra-abdominal pressure increased 63.95 11.04 26 244464 356 110344453
Language disorder 63.91 11.04 59 244431 3779 110341030
Ascites 63.23 11.04 67 244423 92741 110252068
Febrile convulsion 63.15 11.04 36 244454 1074 110343735
Manic symptom 63.11 11.04 24 244466 272 110344537
Neoplasm progression 62.97 11.04 32 244458 64563 110280246
Hypokinesia 62.81 11.04 145 244345 21681 110323128
Back injury 62.63 11.04 14 244476 47385 110297424
Renal tubular acidosis 62.58 11.04 64 244426 4651 110340158
Miosis 62.12 11.04 145 244345 21838 110322971
Dysgeusia 62.01 11.04 39 244451 69946 110274863
Alcohol abuse 61.99 11.04 65 244425 4864 110339945
Sluggishness 61.93 11.04 80 244410 7487 110337322
Exostosis 61.89 11.04 13 244477 45943 110298866
Blepharospasm 61.73 11.04 22 244468 54829 110289980
Haemoptysis 61.53 11.04 41 244449 71313 110273496
Congenital hand malformation 61.40 11.04 12 244478 0 110344809
Educational problem 61.14 11.04 28 244462 520 110344289
Ileus paralytic 60.87 11.04 100 244390 11637 110333172
Cardiac failure 60.59 11.04 212 244278 187414 110157395
Tonic clonic movements 60.39 11.04 51 244439 2901 110341908
Coma scale abnormal 60.36 11.04 90 244400 9636 110335173
Postictal state 60.04 11.04 47 244443 2399 110342410
Drop attacks 59.95 11.04 35 244455 1093 110343716
Intestinal ischaemia 59.83 11.04 119 244371 16060 110328749
Injection site swelling 59.65 11.04 31 244459 61759 110283050
Judgement impaired 59.64 11.04 37 244453 1293 110343516
Disease recurrence 59.24 11.04 279 244211 60505 110284304
Agranulocytosis 59.12 11.04 282 244208 61478 110283331
Hepatotoxicity 58.89 11.04 287 244203 63113 110281696
Hepatic failure 58.80 11.04 304 244186 68435 110276374
Hypospadias 58.00 11.04 19 244471 133 110344676
Hepatic enzyme increased 57.97 11.04 443 244047 320449 110024360
Automatism 57.92 11.04 21 244469 206 110344603
Mood swings 57.53 11.04 144 244346 22668 110322141
Social avoidant behaviour 57.40 11.04 65 244425 5304 110339505
Disorganised speech 57.39 11.04 52 244438 3251 110341558
Staring 57.19 11.04 49 244441 2843 110341966
Sarcoidosis 57.08 11.04 101 244389 12478 110332331
Cataract 56.87 11.04 55 244435 79430 110265379
Flushing 56.54 11.04 90 244400 104646 110240163
Prostate cancer 56.49 11.04 8 244482 37633 110307176
Flight of ideas 56.14 11.04 30 244460 786 110344023
Mutism 56.04 11.04 50 244440 3063 110341746
Brugada syndrome 56.02 11.04 38 244452 1550 110343259
Pneumocystis jirovecii pneumonia 55.71 11.04 13 244477 42722 110302087
Bone pain 55.40 11.04 38 244452 65095 110279714
Negativism 55.20 11.04 31 244459 898 110343911
Epileptic encephalopathy 55.20 11.04 28 244462 657 110344152
Oropharyngeal pain 55.17 11.04 137 244353 135139 110209670
Withdrawal catatonia 55.15 11.04 24 244466 393 110344416
Gastrooesophageal reflux disease 55.05 11.04 208 244282 179768 110165041
Hyperosmolar state 54.93 11.04 29 244461 741 110344068
Basal cell carcinoma 54.76 11.04 16 244474 45254 110299555
Sinus tachycardia 54.68 11.04 219 244271 44274 110300535
Blood pressure fluctuation 54.44 11.04 51 244439 74773 110270036
Platelet count decreased 54.37 11.04 762 243728 229681 110115128
Faecaloma 54.35 11.04 109 244381 14799 110330010
Upper respiratory tract infection 54.34 11.04 132 244358 131196 110213613
Heart rate decreased 53.90 11.04 62 244428 82694 110262115
Amenorrhoea 53.86 11.04 83 244407 9148 110335661
Drug level above therapeutic 53.83 11.04 94 244396 11494 110333315
Delusional disorder, unspecified type 53.67 11.04 30 244460 861 110343948
Therapeutic product effect variable 53.64 11.04 46 244444 2672 110342137
Hypersexuality 53.61 11.04 40 244450 1900 110342909
Pneumonitis 53.55 11.04 54 244436 76477 110268332
Refusal of treatment by patient 53.49 11.04 84 244406 9410 110335399
Live birth 53.39 11.04 45 244445 69439 110275370
Paroxysmal perceptual alteration 52.91 11.04 21 244469 269 110344540
Incoherent 52.82 11.04 78 244412 8280 110336529
Road traffic accident 52.75 11.04 98 244392 107300 110237509
Bruxism 52.61 11.04 60 244430 4934 110339875
Cerebrovascular accident 52.58 11.04 214 244276 181070 110163739
Sinus congestion 52.05 11.04 4 244486 30455 110314354
Intentional product misuse 51.97 11.04 485 244005 132419 110212390
Aphasia 51.21 11.04 262 244228 58735 110286074
Tic 51.12 11.04 50 244440 3443 110341366
Suicidal behaviour 51.07 11.04 50 244440 3447 110341362
Paraesthesia oral 50.90 11.04 7 244483 33664 110311145
Torticollis 50.72 11.04 48 244442 3173 110341636
Liver injury 50.57 11.04 167 244323 150246 110194563
Injection site bruising 50.56 11.04 25 244465 51238 110293571
Drug dependence 50.52 11.04 232 244258 49788 110295021
Polydipsia 50.40 11.04 73 244417 7615 110337194
Metabolic syndrome 50.39 11.04 48 244442 3199 110341610
Postictal psychosis 50.34 11.04 20 244470 257 110344552
Homicide 50.18 11.04 31 244459 1075 110343734
Product dose omission issue 50.09 11.04 462 244028 321320 110023489
Diverticulitis 49.99 11.04 28 244462 53494 110291315
Conjunctival hyperaemia 49.85 11.04 63 244427 5768 110339041
Soliloquy 49.71 11.04 30 244460 997 110343812
Pancreatitis necrotising 49.54 11.04 61 244429 5440 110339369
Oral mucosa erosion 49.48 11.04 42 244448 2406 110342403
Off label use 49.41 11.04 3901 240589 1496284 108848525
Dizziness 49.38 11.04 1171 243319 697022 109647787
Pulmonary mass 49.32 11.04 11 244479 37290 110307519
Balance disorder 48.95 11.04 432 244058 116128 110228681
Intensive care unit acquired weakness 48.76 11.04 41 244449 2318 110342491
Metastases to bone 48.68 11.04 6 244484 31366 110313443
Cardiac arrest 48.61 11.04 656 243834 196097 110148712
Hyperglycinaemia 48.55 11.04 10 244480 3 110344806
Product use in unapproved indication 48.27 11.04 1313 243177 446064 109898745
Excessive eye blinking 48.23 11.04 37 244453 1833 110342976
Ear pain 48.07 11.04 29 244461 53197 110291612
Angiofibroma 47.78 11.04 16 244474 121 110344688
Onychomycosis 47.76 11.04 13 244477 38518 110306291
Finger deformity 47.46 11.04 8 244482 33084 110311725
Palpitations 47.40 11.04 186 244304 159026 110185783
Hyperphagia 46.99 11.04 48 244442 3483 110341326
Palmar-plantar erythrodysaesthesia syndrome 46.95 11.04 16 244474 41009 110303800
Self-destructive behaviour 46.69 11.04 27 244463 828 110343981
Post-injection delirium sedation syndrome 46.61 11.04 26 244464 743 110344066
Coronary artery disease 46.37 11.04 54 244436 71636 110273173
Pain in jaw 46.06 11.04 28 244462 51149 110293660
Liver function test increased 46.02 11.04 78 244412 88470 110256339
Cytomegalovirus infection 45.99 11.04 32 244458 54412 110290397
Illness 45.89 11.04 69 244421 82102 110262707
Food interaction 45.72 11.04 38 244452 2114 110342695
Neglect of personal appearance 45.71 11.04 21 244469 393 110344416
Ulcer 45.69 11.04 19 244471 43097 110301712
Bronchopulmonary aspergillosis 45.64 11.04 6 244484 29857 110314952
Dementia 45.61 11.04 164 244326 31509 110313300
Sudden death 45.60 11.04 138 244352 24257 110320552
Poisoning deliberate 45.56 11.04 145 244345 26186 110318623
Weight decreased 45.51 11.04 744 243746 467313 109877496
Oedema peripheral 45.27 11.04 486 244004 328174 110016635
Anticonvulsant drug level abnormal 45.13 11.04 13 244477 55 110344754
Osteonecrosis of jaw 45.02 11.04 25 244465 47992 110296817
Aspergillus infection 44.82 11.04 3 244487 25613 110319196
Immunodeficiency 44.70 11.04 15 244475 38823 110305986
Cystitis 44.62 11.04 48 244442 65988 110278821
Pulmonary arterial hypertension 44.29 11.04 9 244481 32559 110312250
Confabulation 44.05 11.04 22 244468 499 110344310
Motor developmental delay 43.85 11.04 18 244472 253 110344556
Liver disorder 43.75 11.04 164 244326 142079 110202730
Metastases to liver 43.74 11.04 12 244478 35374 110309435
Chronic sinusitis 43.71 11.04 3 244487 25081 110319728
Dysgraphia 43.71 11.04 53 244437 4652 110340157
Pneumonia 43.68 11.04 1543 242947 875171 109469638
Pulmonary embolism 43.64 11.04 286 244204 214188 110130621
Subileus 43.48 11.04 62 244428 6375 110338434
Neutrophil Pelger-Huet anomaly present 43.40 11.04 20 244470 377 110344432
Adverse event 42.97 11.04 112 244378 108697 110236112
Nasal polyps 42.83 11.04 92 244398 13108 110331701
Hypersomnia 42.74 11.04 148 244342 27913 110316896
Procedural pain 42.24 11.04 13 244477 35552 110309257
Respiratory acidosis 42.17 11.04 94 244396 13732 110331077
Cerebral salt-wasting syndrome 42.14 11.04 18 244472 281 110344528
Perseveration 42.01 11.04 20 244470 407 110344402
Hypervolaemia 41.87 11.04 29 244461 49431 110295378
Oscillopsia 41.79 11.04 20 244470 412 110344397
Acute myeloid leukaemia 41.68 11.04 16 244474 38094 110306715
Convulsive threshold lowered 41.67 11.04 27 244463 1019 110343790
Blood triglycerides increased 41.62 11.04 132 244358 23794 110321015
Coagulopathy 41.50 11.04 190 244300 40721 110304088
Schizoaffective disorder bipolar type 41.46 11.04 18 244472 293 110344516
Microcephaly 41.40 11.04 16 244474 190 110344619
Laryngitis 41.35 11.04 21 244469 42390 110302419
Rebound effect 41.12 11.04 97 244393 14709 110330100
Eczema 41.06 11.04 60 244430 72233 110272576
Flatulence 41.02 11.04 33 244457 52116 110292693
Rash maculo-papular 40.99 11.04 293 244197 73929 110270880
Tumour lysis syndrome 40.89 11.04 9 244481 30792 110314017
Sinus disorder 40.64 11.04 11 244479 32717 110312092
Hypotension 40.56 11.04 1477 243013 522372 109822437
Anxiety 40.45 11.04 1024 243466 344054 110000755
Hepatic adenoma 40.31 11.04 20 244470 447 110344362
Angina pectoris 40.21 11.04 47 244443 62248 110282561
Systemic inflammatory response syndrome 40.15 11.04 89 244401 12954 110331855
Rhinitis allergic 39.93 11.04 108 244382 17814 110326995
Blood pressure diastolic abnormal 39.90 11.04 5 244485 25810 110318999
Stereotypy 39.90 11.04 26 244464 991 110343818
Colitis 39.89 11.04 106 244384 102217 110242592
Head titubation 39.79 11.04 29 244461 1328 110343481
Transaminases increased 39.63 11.04 258 244232 63132 110281677
Epileptic psychosis 39.55 11.04 12 244478 63 110344746
Sneezing 39.25 11.04 11 244479 31973 110312836
Productive cough 39.05 11.04 126 244364 114179 110230630
Screaming 39.00 11.04 51 244439 4830 110339979
Anion gap increased 38.84 11.04 48 244442 4296 110340513
Tachyphrenia 38.81 11.04 36 244454 2320 110342489
Cryptorchism 38.68 11.04 11 244479 44 110344765
Gamma-glutamyltransferase increased 38.61 11.04 250 244240 61059 110283750
Akinesia 38.53 11.04 44 244446 3623 110341186
Vagal nerve stimulator implantation 38.40 11.04 16 244474 234 110344575
Clonus 38.29 11.04 69 244421 8647 110336162
Oral candidiasis 38.22 11.04 26 244464 44734 110300075
Lymphocyte count increased 38.20 11.04 62 244428 7141 110337668
Inappropriate affect 38.19 11.04 31 244459 1668 110343141
Blood pressure systolic abnormal 37.96 11.04 5 244485 24845 110319964
Upper gastrointestinal haemorrhage 37.81 11.04 33 244457 50063 110294746
Hyperreflexia 37.79 11.04 72 244418 9413 110335396
Anaphylactic shock 37.65 11.04 35 244455 51511 110293298
Rabbit syndrome 37.60 11.04 18 244472 371 110344438
Neurodevelopmental disorder 37.53 11.04 12 244478 77 110344732
Coloboma 37.26 11.04 9 244481 15 110344794
Melaena 37.19 11.04 59 244431 68698 110276111
Shock 37.18 11.04 224 244266 53364 110291445
Simple partial seizures 37.05 11.04 25 244465 1011 110343798
Coeliac disease 36.99 11.04 25 244465 43162 110301647
Skin ulcer 36.96 11.04 52 244438 63593 110281216
Postural tremor 36.91 11.04 25 244465 1017 110343792
Respiratory arrest 36.89 11.04 238 244252 58061 110286748
Transfusion 36.88 11.04 6 244484 25466 110319343
Monocyte count increased 36.82 11.04 87 244403 13206 110331603
White blood cell count decreased 36.46 11.04 711 243779 228679 110116130
Product administration error 36.39 11.04 171 244319 37046 110307763
Rebound psychosis 36.37 11.04 18 244472 400 110344409
Fanconi syndrome acquired 36.36 11.04 39 244451 2995 110341814
Wrong product administered 36.26 11.04 77 244413 10883 110333926
Renal failure 36.25 11.04 323 244167 226251 110118558
Hyperchloraemia 36.25 11.04 27 244463 1279 110343530
Sinus bradycardia 36.13 11.04 145 244345 29338 110315471
Suspiciousness 36.08 11.04 22 244468 745 110344064
Therapy partial responder 36.03 11.04 170 244320 36891 110307918
Urinary tract infection 36.02 11.04 506 243984 325776 110019033
Normal pressure hydrocephalus 35.91 11.04 20 244470 570 110344239
Cerebellar syndrome 35.84 11.04 56 244434 6246 110338563
Breast hyperplasia 35.73 11.04 14 244476 173 110344636
Poverty of speech 35.56 11.04 20 244470 581 110344228
Borderline personality disorder 35.44 11.04 25 244465 1087 110343722
Device expulsion 35.43 11.04 12 244478 30879 110313930
Blood osmolarity decreased 35.42 11.04 28 244462 1450 110343359
COVID-19 pneumonia 35.31 11.04 19 244471 37124 110307685
Maternal exposure timing unspecified 35.24 11.04 3 244487 21010 110323799
Nodule 35.19 11.04 14 244476 32617 110312192
Dry eye 35.05 11.04 43 244447 55750 110289059
Diplopia 34.94 11.04 184 244306 41710 110303099
Apraxia 34.73 11.04 41 244449 3499 110341310
Neck pain 34.67 11.04 147 244343 122983 110221826
Vascular encephalopathy 34.63 11.04 22 244468 802 110344007
Troponin increased 34.59 11.04 144 244346 29622 110315187
Mitochondrial cytopathy 34.34 11.04 17 244473 378 110344431
CSF oligoclonal band present 34.30 11.04 18 244472 454 110344355
Rash pruritic 34.27 11.04 107 244383 97962 110246847
Hypoventilation 34.27 11.04 63 244427 8018 110336791
Localised infection 34.16 11.04 27 244463 43021 110301788
Saccadic eye movement 34.15 11.04 14 244476 196 110344613
Foot deformity 34.15 11.04 34 244456 48446 110296363
Uveitis 34.06 11.04 4 244486 21706 110323103
Verbal abuse 33.95 11.04 16 244474 318 110344491
Brief psychotic disorder, with postpartum onset 33.88 11.04 9 244481 26 110344783
Incontinence 33.86 11.04 97 244393 16538 110328271
Developmental regression 33.53 11.04 10 244480 49 110344760
Cellulitis 33.34 11.04 154 244336 125862 110218947
Pulmonary hypertension 33.19 11.04 44 244446 55176 110289633
Blood gases abnormal 33.13 11.04 26 244464 1332 110343477
Dysphagia 33.08 11.04 500 243990 153100 110191709
Pneumatosis 33.06 11.04 23 244467 978 110343831
Food allergy 33.04 11.04 3 244487 19945 110324864
Aura 32.91 11.04 24 244466 1100 110343709
Adjustment disorder with mixed anxiety and depressed mood 32.89 11.04 12 244478 120 110344689
Anticoagulation drug level decreased 32.73 11.04 15 244475 279 110344530
Hypertelorism 32.72 11.04 13 244477 167 110344642
Drug-disease interaction 32.70 11.04 30 244460 1906 110342903
Galactorrhoea 32.56 11.04 43 244447 4112 110340697
Gender dysphoria 32.27 11.04 10 244480 57 110344752
Bacteraemia 31.90 11.04 28 244462 42362 110302447
Gynaecomastia 31.78 11.04 67 244423 9423 110335386
Acute myocardial infarction 31.75 11.04 88 244402 83689 110261120
Clonic convulsion 31.71 11.04 27 244463 1553 110343256
Epidermolysis bullosa 31.56 11.04 16 244474 375 110344434
Renal fusion anomaly 31.50 11.04 7 244483 6 110344803
Bladder cancer 31.20 11.04 4 244486 20288 110324521
Skin exfoliation 31.08 11.04 95 244395 87556 110257253
Fungal infection 31.03 11.04 40 244450 50766 110294043
Spasmodic dysphonia 30.98 11.04 18 244472 557 110344252
Dysphonia 30.87 11.04 77 244413 75852 110268957
Arrhythmia 30.85 11.04 261 244229 69314 110275495
Gastrointestinal sounds abnormal 30.84 11.04 51 244439 5967 110338842
Thought blocking 30.82 11.04 14 244476 255 110344554
Breast cancer 30.81 11.04 24 244466 38518 110306291
Adrenal insufficiency 30.71 11.04 29 244461 42361 110302448
Osteoporosis 30.52 11.04 95 244395 87057 110257752
Sedation complication 30.48 11.04 105 244385 19750 110325059
Distractibility 30.46 11.04 21 244469 880 110343929
Therapeutic product effective for unapproved indication 30.43 11.04 12 244478 151 110344658
Cardio-respiratory arrest 30.17 11.04 390 244100 115446 110229363
Tendonitis 30.15 11.04 10 244480 26073 110318736
Ovarian granulosa-theca cell tumour 30.15 11.04 8 244482 23 110344786
Glycosuria 30.11 11.04 33 244457 2597 110342212
Limbic encephalitis 30.10 11.04 20 244470 788 110344021
Abdominal distension 30.08 11.04 245 244245 174858 110169951
Multiple congenital abnormalities 30.06 11.04 11 244479 111 110344698
Hypertrophic cardiomyopathy 29.99 11.04 36 244454 3127 110341682
Megacolon 29.87 11.04 42 244448 4263 110340546
Thermal burn 29.83 11.04 59 244431 7929 110336880
Suspected suicide attempt 29.69 11.04 15 244475 349 110344460
Pleocytosis 29.67 11.04 27 244463 1697 110343112
Oligoasthenozoospermia 29.63 11.04 7 244483 10 110344799
Skin haemorrhage 29.62 11.04 9 244481 24818 110319991
Device issue 29.56 11.04 20 244470 34515 110310294
Lupus-like syndrome 29.44 11.04 28 244462 40764 110304045
Pectus excavatum 29.23 11.04 7 244483 11 110344798
Second primary malignancy 29.18 11.04 3 244487 18065 110326744
Candida infection 29.12 11.04 38 244452 47971 110296838
Echolalia 29.03 11.04 17 244473 534 110344275
Crying 29.01 11.04 123 244367 25505 110319304
Oropharyngeal oedema 28.95 11.04 16 244474 449 110344360
Brain death 28.83 11.04 52 244438 6521 110338288
Strabismus 28.65 11.04 37 244453 3462 110341347
Polyarthritis 28.53 11.04 4 244486 18959 110325850
Angiomyolipoma 28.42 11.04 14 244476 308 110344501
Product administered to patient of inappropriate age 28.39 11.04 58 244432 7978 110336831
Limb discomfort 28.38 11.04 29 244461 40825 110303984
Walking aid user 28.31 11.04 10 244480 25065 110319744
Failure to suspend medication 28.29 11.04 16 244474 470 110344339
Developmental coordination disorder 28.27 11.04 6 244484 3 110344806
Hallucination, tactile 28.21 11.04 21 244469 994 110343815
Hyperkalaemia 28.17 11.04 180 244310 135616 110209193
Frontotemporal dementia 28.12 11.04 18 244472 665 110344144
Brain malformation 28.11 11.04 9 244481 58 110344751
Eye pain 28.04 11.04 42 244448 50057 110294752
Ammonia abnormal 28.01 11.04 14 244476 318 110344491
Back disorder 28.00 11.04 6 244484 20916 110323893
Bone marrow oedema syndrome 27.98 11.04 9 244481 59 110344750
Niemann-Pick disease 27.93 11.04 8 244482 33 110344776
Psychotic behaviour 27.88 11.04 24 244466 1401 110343408
Deja vu 27.86 11.04 10 244480 95 110344714
Substance-induced psychotic disorder 27.84 11.04 46 244444 5378 110339431
Fat embolism syndrome 27.78 11.04 11 244479 140 110344669
Unmasking of previously unidentified disease 27.78 11.04 33 244457 2835 110341974
SJS-TEN overlap 27.75 11.04 27 244463 1847 110342962
Gout 27.70 11.04 24 244466 36542 110308267
Dyslipidaemia 27.70 11.04 88 244402 15877 110328932
Accidental overdose 27.69 11.04 203 244287 51631 110293178
Inappropriate schedule of product administration 27.67 11.04 302 244188 203335 110141474
Gene mutation 27.67 11.04 36 244454 3393 110341416
Reflexes abnormal 27.63 11.04 21 244469 1026 110343783
Ear infection 27.60 11.04 61 244429 62671 110282138
Cardiogenic shock 27.56 11.04 53 244437 57285 110287524
Electrocardiogram QRS complex prolonged 27.55 11.04 77 244413 12944 110331865
Transplant rejection 27.40 11.04 10 244480 24557 110320252
Eye movement disorder 27.30 11.04 64 244426 9664 110335145
Poor personal hygiene 27.20 11.04 17 244473 602 110344207
Skin fissures 27.20 11.04 10 244480 24448 110320361
Parkinsonian gait 27.19 11.04 21 244469 1051 110343758
Blood urea decreased 27.17 11.04 36 244454 3454 110341355
Swollen tongue 27.13 11.04 58 244432 60304 110284505
Anticholinergic syndrome 27.13 11.04 40 244450 4240 110340569
Stress 27.12 11.04 130 244360 105218 110239591
Blood osmolarity increased 27.02 11.04 19 244471 822 110343987
Neutrophilia 26.89 11.04 66 244424 10263 110334546
Ventricular arrhythmia 26.84 11.04 65 244425 10022 110334787
Cardiac disorder 26.81 11.04 83 244407 76197 110268612
Surgery 26.80 11.04 31 244459 41252 110303557
Patient isolation 26.77 11.04 9 244481 69 110344740
Lactate pyruvate ratio increased 26.77 11.04 9 244481 69 110344740
Myoglobinuria 26.75 11.04 22 244468 1206 110343603
Substance abuse 26.67 11.04 74 244416 12389 110332420
Right ventricular failure 26.61 11.04 12 244478 25942 110318867
Compulsive shopping 26.48 11.04 19 244471 849 110343960
Hereditary ataxia 26.41 11.04 7 244483 20 110344789
Peripheral sensory neuropathy 26.35 11.04 3 244487 16677 110328132
Haemorrhoids 26.32 11.04 24 244466 35648 110309161
Hyporesponsive to stimuli 26.21 11.04 32 244458 2828 110341981
Pulmonary valve incompetence 26.17 11.04 31 244459 2655 110342154
Anaemia macrocytic 26.15 11.04 53 244437 7250 110337559
Metabolic disorder 26.14 11.04 66 244424 10444 110334365
Hostility 26.08 11.04 31 244459 2665 110342144
Hyperhomocysteinaemia 26.04 11.04 17 244473 650 110344159
Cerebral ventricle dilatation 26.03 11.04 21 244469 1120 110343689
Vascular device infection 26.01 11.04 3 244487 16509 110328300
Skin disorder 25.99 11.04 34 244456 42879 110301930
Device difficult to use 25.99 11.04 5 244485 18800 110326009
Sepsis 25.95 11.04 539 243951 326807 110018002
Dyspraxia 25.94 11.04 13 244477 297 110344512
Neurological decompensation 25.90 11.04 51 244439 6832 110337977
Neuralgia 25.84 11.04 42 244448 48436 110296373
Movement disorder 25.78 11.04 153 244337 36251 110308558
Drug eruption 25.78 11.04 205 244285 53454 110291355
Choroidal coloboma 25.58 11.04 5 244485 0 110344809
Alpers disease 25.58 11.04 5 244485 0 110344809
Hypotelorism of orbit 25.58 11.04 5 244485 0 110344809
Sputum discoloured 25.55 11.04 15 244475 27930 110316879
Febrile bone marrow aplasia 25.55 11.04 4 244486 17461 110327348
Sinus rhythm 25.51 11.04 20 244470 1023 110343786
Inhibitory drug interaction 25.45 11.04 42 244448 4905 110339904
Cardiac murmur 25.44 11.04 115 244375 24513 110320296
Injection site warmth 25.43 11.04 4 244486 17401 110327408
Aspiration 25.39 11.04 134 244356 30399 110314410
Throat tightness 25.35 11.04 22 244468 33467 110311342
Abdominal compartment syndrome 25.29 11.04 26 244464 1901 110342908
Emotional disorder 25.28 11.04 86 244404 16074 110328735
Ketosis-prone diabetes mellitus 25.20 11.04 8 244482 50 110344759
Hepatocellular injury 25.17 11.04 195 244295 50447 110294362
Ultrasound ovary abnormal 24.85 11.04 9 244481 88 110344721
Acute coronary syndrome 24.79 11.04 10 244480 23102 110321707
Polydipsia psychogenic 24.74 11.04 13 244477 329 110344480
Hypotonia neonatal 24.67 11.04 9 244481 90 110344719
Major depression 24.67 11.04 65 244425 10556 110334253
Dyscalculia 24.59 11.04 10 244480 137 110344672
Kidney infection 24.48 11.04 13 244477 25586 110319223
Head injury 24.44 11.04 171 244319 42846 110301963
Reduced facial expression 24.42 11.04 35 244455 3616 110341193
Ornithine transcarbamoylase deficiency 24.42 11.04 7 244483 29 110344780
Clostridium difficile infection 24.35 11.04 49 244441 52080 110292729
Asphyxia 24.34 11.04 78 244412 14137 110330672
Foreign body aspiration 24.29 11.04 15 244475 520 110344289
Antisocial behaviour 24.21 11.04 18 244472 850 110343959
Post transplant lymphoproliferative disorder 24.19 11.04 3 244487 15610 110329199
Musculoskeletal discomfort 23.95 11.04 11 244479 23527 110321282
Decreased gait velocity 23.94 11.04 11 244479 206 110344603
Acute psychosis 23.88 11.04 41 244449 4946 110339863
Ulcer haemorrhage 23.83 11.04 10 244480 22561 110322248
Cerebral disorder 23.80 11.04 49 244441 6777 110338032
Dehydration 23.72 11.04 455 244035 279056 110065753
Weight increased 23.54 11.04 1144 243346 418500 109926309
Oral herpes 23.52 11.04 27 244463 36053 110308756
Intelligence test abnormal 23.51 11.04 6 244484 14 110344795
Necrotising colitis 23.50 11.04 24 244466 1741 110343068
Disturbance in social behaviour 23.45 11.04 41 244449 5017 110339792
Blood sodium increased 23.35 11.04 43 244447 5480 110339329
Squamous cell carcinoma 23.32 11.04 6 244484 18457 110326352
Clostridium difficile colitis 23.27 11.04 38 244452 43740 110301069
Sleep-related eating disorder 23.20 11.04 18 244472 907 110343902
Metastases to lung 23.12 11.04 11 244479 23052 110321757
Hyperventilation 23.11 11.04 57 244433 8890 110335919
Radiculopathy 23.09 11.04 7 244483 19329 110325480
Nephrocalcinosis 22.95 11.04 24 244466 1790 110343019
Therapeutic product ineffective for unapproved indication 22.89 11.04 12 244478 302 110344507
Gastrointestinal hypomotility 22.89 11.04 28 244462 2480 110342329
Coma hepatic 22.84 11.04 19 244471 1058 110343751
Precocious puberty 22.80 11.04 13 244477 388 110344421
Laboratory test abnormal 22.74 11.04 39 244451 44040 110300769
Diabetic coma 22.72 11.04 21 244469 1347 110343462
Lacrimation increased 22.62 11.04 21 244469 30929 110313880
Water intoxication 22.62 11.04 18 244472 941 110343868
Trismus 22.59 11.04 47 244443 6549 110338260
Cerebellar microhaemorrhage 22.58 11.04 7 244483 40 110344769
Joint effusion 22.49 11.04 9 244481 20896 110323913
Epileptic aura 22.48 11.04 8 244482 74 110344735
Septic shock 22.46 11.04 231 244259 157297 110187512
IVth nerve disorder 22.42 11.04 6 244484 18 110344791
Astrocytoma, low grade 22.35 11.04 9 244481 120 110344689
Excessive masturbation 22.35 11.04 9 244481 120 110344689
Carpal tunnel syndrome 22.34 11.04 11 244479 22599 110322210
Injection site rash 22.23 11.04 12 244478 23407 110321402
Drug tolerance decreased 22.20 11.04 17 244473 27523 110317286
Talipes 22.17 11.04 10 244480 179 110344630
Faecal vomiting 22.14 11.04 22 244468 1544 110343265
Cholelithiasis 22.11 11.04 226 244264 63196 110281613
Illogical thinking 22.11 11.04 8 244482 78 110344731
Hepatic steatosis 22.08 11.04 184 244306 48647 110296162
Full blood count decreased 22.06 11.04 23 244467 32076 110312733
Eye infection 21.99 11.04 3 244487 14515 110330294
Muscle twitching 21.97 11.04 127 244363 29808 110315001
Electrocardiogram T wave abnormal 21.96 11.04 36 244454 4181 110340628
Neoplasm malignant 21.91 11.04 30 244460 37113 110307696
Hypothyroidism 21.83 11.04 252 244238 72647 110272162
Hypophosphataemic osteomalacia 21.76 11.04 13 244477 424 110344385
Mixed delusion 21.72 11.04 6 244484 21 110344788
Pancreatitis haemorrhagic 21.71 11.04 18 244472 998 110343811
Hernia 21.64 11.04 8 244482 19492 110325317
Quadriparesis 21.63 11.04 38 244452 4669 110340140
Circulatory collapse 21.62 11.04 166 244324 42827 110301982
Nose deformity 21.38 11.04 11 244479 266 110344543
Pneumothorax 21.32 11.04 28 244462 35257 110309552
Labelled drug-drug interaction medication error 21.30 11.04 124 244366 29178 110315631
Urine amphetamine positive 21.28 11.04 9 244481 137 110344672
Tuberous sclerosis complex 21.28 11.04 9 244481 137 110344672
Alcohol use 21.21 11.04 35 244455 4087 110340722
Venoocclusive liver disease 21.11 11.04 4 244486 15203 110329606
Product dose omission in error 20.97 11.04 13 244477 23499 110321310
Aminoaciduria 20.87 11.04 12 244478 364 110344445
Consciousness fluctuating 20.83 11.04 25 244465 2171 110342638
Mucosal ulceration 20.81 11.04 26 244464 2353 110342456
Blood urine present 20.81 11.04 14 244476 24231 110320578
Intervertebral disc degeneration 20.79 11.04 7 244483 18078 110326731
Intestinal pseudo-obstruction 20.75 11.04 31 244459 3325 110341484
Blood loss anaemia 20.68 11.04 7 244483 18018 110326791
Intestinal obstruction 20.67 11.04 194 244296 53033 110291776
Blood bicarbonate decreased 20.67 11.04 42 244448 5755 110339054
Hyperexplexia 20.67 11.04 7 244483 55 110344754
Posterior reversible encephalopathy syndrome 20.67 11.04 137 244353 33724 110311085
Type 1 diabetes mellitus 20.64 11.04 55 244435 8992 110335817
Respiratory symptom 20.60 11.04 4 244486 14941 110329868
Syndactyly 20.48 11.04 9 244481 151 110344658
Megakaryocytes 20.47 11.04 4 244486 0 110344809
Gaucher's disease 20.47 11.04 4 244486 0 110344809
Congenital nose malformation 20.47 11.04 4 244486 0 110344809
Hypocarnitinaemia 20.47 11.04 4 244486 0 110344809
Hypersomnia-bulimia syndrome 20.46 11.04 5 244485 9 110344800
Pancreatic carcinoma 20.45 11.04 4 244486 14868 110329941
Social anxiety disorder 20.40 11.04 17 244473 949 110343860
Diffuse large B-cell lymphoma 20.40 11.04 5 244485 15893 110328916
Muscle contracture 20.39 11.04 28 244462 2780 110342029
Device dislocation 20.37 11.04 24 244466 31680 110313129
Brain stem microhaemorrhage 20.35 11.04 6 244484 28 110344781
Procalcitonin increased 20.28 11.04 34 244456 4022 110340787
Ageusia 20.27 11.04 9 244481 19636 110325173
Mucosal erosion 20.26 11.04 28 244462 2796 110342013
Pneumonia fungal 20.23 11.04 4 244486 14750 110330059
Tooth infection 20.21 11.04 12 244478 22204 110322605
Temporal lobe epilepsy 20.20 11.04 13 244477 485 110344324
Slow speech 20.11 11.04 31 244459 3417 110341392
Rasmussen encephalitis 20.11 11.04 5 244485 10 110344799
Lymphangioleiomyomatosis 20.09 11.04 10 244480 225 110344584
Nervousness 20.07 11.04 145 244345 36706 110308103
Low set ears 19.98 11.04 8 244482 105 110344704
Megakaryocytes abnormal 19.98 11.04 8 244482 105 110344704
Apnoea 19.96 11.04 71 244419 13568 110331241
Erythema multiforme 19.95 11.04 96 244394 21001 110323808
Neutrophil count decreased 19.93 11.04 377 244113 120564 110224245
Hiatus hernia 19.86 11.04 19 244471 27587 110317222
Lip haemorrhage 19.80 11.04 20 244470 1432 110343377
Extensor plantar response 19.77 11.04 23 244467 1932 110342877
Therapeutic response changed 19.75 11.04 21 244469 1597 110343212
Angioedema 19.70 11.04 132 244358 98368 110246441
Macroglossia 19.70 11.04 20 244470 1441 110343368
Lymphoma 19.65 11.04 10 244480 20161 110324648
Mitochondrial encephalomyopathy 19.65 11.04 8 244482 110 110344699
Gastric disorder 19.62 11.04 27 244463 33330 110311479
Hepatitis C virus test positive 19.61 11.04 12 244478 409 110344400
Brain injury 19.59 11.04 70 244420 13406 110331403
Haematocrit decreased 19.55 11.04 228 244262 65889 110278920
Cataplexy 19.52 11.04 18 244472 1151 110343658
Myelodysplastic syndrome 19.49 11.04 33 244457 37451 110307358
Anorgasmia 19.45 11.04 21 244469 1625 110343184
Hypertriglyceridaemia 19.44 11.04 79 244411 16075 110328734
Intention tremor 19.44 11.04 16 244474 878 110343931
Condition aggravated 19.39 11.04 1881 242609 732955 109611854
Hyperpyrexia 19.37 11.04 50 244440 8019 110336790
Shock haemorrhagic 19.32 11.04 19 244471 27228 110317581
Forced expiratory volume decreased 19.31 11.04 3 244487 13173 110331636
Somatic symptom disorder 19.27 11.04 29 244461 3130 110341679
Feeling of despair 19.21 11.04 32 244458 3766 110341043
Blood pressure diastolic decreased 19.21 11.04 31 244459 35854 110308955
Hip fracture 19.16 11.04 30 244460 35121 110309688
Intracranial pressure increased 19.13 11.04 59 244431 10476 110334333
Drug monitoring procedure incorrectly performed 19.12 11.04 15 244475 768 110344041
Pregnancy 19.08 11.04 54 244436 51013 110293796
Patent ductus arteriosus 19.05 11.04 9 244481 180 110344629
Impaired quality of life 18.99 11.04 23 244467 29994 110314815
Intervertebral disc protrusion 18.86 11.04 20 244470 27678 110317131
Acquired macroglossia 18.85 11.04 10 244480 258 110344551
School refusal 18.83 11.04 6 244484 38 110344771
Product use issue 18.73 11.04 535 243955 311160 110033649
Mitochondrial toxicity 18.68 11.04 29 244461 3216 110341593
Device related infection 18.58 11.04 37 244453 39482 110305327
Skin cancer 18.58 11.04 8 244482 17776 110327033
Upper-airway cough syndrome 18.47 11.04 6 244484 15851 110328958
Lipids 18.44 11.04 5 244485 16 110344793
Hyporeflexia 18.36 11.04 33 244457 4127 110340682
Benign cardiac neoplasm 18.32 11.04 6 244484 42 110344767
Haematuria traumatic 18.27 11.04 11 244479 364 110344445
Transient ischaemic attack 18.25 11.04 76 244414 63906 110280903
Gingival pain 18.25 11.04 6 244484 15730 110329079
Gallbladder disorder 18.24 11.04 12 244478 21017 110323792
Hypermetropia 18.24 11.04 12 244478 465 110344344
Blood pyruvic acid increased 18.24 11.04 4 244486 3 110344806
Camptodactyly congenital 18.24 11.04 4 244486 3 110344806
Substance use 18.21 11.04 25 244465 2481 110342328
Motor dysfunction 18.21 11.04 104 244386 24302 110320507
Injection site haemorrhage 18.18 11.04 28 244462 33000 110311809
Opsoclonus myoclonus 18.11 11.04 10 244480 280 110344529
Posturing 18.07 11.04 17 244473 1115 110343694
Enteritis 17.92 11.04 10 244480 19146 110325663
Personal relationship issue 17.91 11.04 9 244481 207 110344602
Blood catecholamines increased 17.83 11.04 7 244483 87 110344722
Prostatic pain 17.83 11.04 10 244480 289 110344520
Gliosis 17.83 11.04 14 244476 718 110344091
Colon cancer 17.82 11.04 7 244483 16436 110328373
Rash morbilliform 17.80 11.04 48 244442 7903 110336906
Basilar artery occlusion 17.80 11.04 10 244480 290 110344519
Anticonvulsant drug level therapeutic 17.78 11.04 5 244485 19 110344790
Vasoplegia syndrome 17.75 11.04 38 244452 5401 110339408
Abulia 17.75 11.04 18 244472 1295 110343514
Numb chin syndrome 17.73 11.04 6 244484 47 110344762
Gangrene 17.64 11.04 7 244483 16334 110328475
Head discomfort 17.63 11.04 86 244404 18914 110325895
Compensatory sweating 17.62 11.04 6 244484 48 110344761
Trichoglossia 17.58 11.04 15 244475 865 110343944
Injection site urticaria 17.58 11.04 8 244482 17207 110327602
Facial spasm 17.55 11.04 15 244475 867 110343942
Faeces discoloured 17.55 11.04 30 244460 33918 110310891
Rickets 17.54 11.04 7 244483 91 110344718
Accidental death 17.52 11.04 36 244454 4973 110339836
Prothrombin time shortened 17.49 11.04 30 244460 3616 110341193
Aptyalism 17.47 11.04 15 244475 873 110343936
Fistula 17.45 11.04 6 244484 15293 110329516
Retinitis pigmentosa 17.40 11.04 8 244482 150 110344659
Emotional disorder of childhood 17.39 11.04 5 244485 21 110344788
Swelling face 17.34 11.04 126 244364 92195 110252614
Graft versus host disease 17.33 11.04 10 244480 18796 110326013
Presyncope 17.32 11.04 53 244437 48834 110295975
Coagulation factor VIII level decreased 17.31 11.04 6 244484 51 110344758
Tooth abscess 17.30 11.04 10 244480 18779 110326030
Intermittent explosive disorder 17.23 11.04 4 244486 5 110344804
Astigmatism 17.11 11.04 20 244470 1689 110343120
Heart rate irregular 17.07 11.04 31 244459 34243 110310566
Influenza B virus test positive 17.03 11.04 11 244479 413 110344396
Blood parathyroid hormone decreased 17.02 11.04 4 244486 13085 110331724
Irregular sleep phase 17.02 11.04 8 244482 158 110344651
Thyroxine free decreased 17.00 11.04 17 244473 1203 110343606
Bacterial infection 16.97 11.04 49 244441 45987 110298822
Opisthotonus 16.95 11.04 14 244476 772 110344037
Circadian rhythm sleep disorder 16.93 11.04 16 244474 1056 110343753
Vomiting 16.92 11.04 1759 242731 908916 109435893
Renal cancer 16.92 11.04 4 244486 13030 110331779
Blood test abnormal 16.91 11.04 23 244467 28531 110316278
Hyperthyroidism 16.90 11.04 24 244466 29237 110315572
Pyromania 16.85 11.04 5 244485 24 110344785
Renal impairment 16.84 11.04 304 244186 188141 110156668
Dermatitis atopic 16.77 11.04 19 244471 25522 110319287
Cerebral palsy 16.77 11.04 10 244480 325 110344484
Blunted affect 16.77 11.04 12 244478 534 110344275
Haemodynamic instability 16.73 11.04 97 244393 22791 110322018
Respiratory disorder 16.72 11.04 91 244399 71291 110273518
Teratogenicity 16.70 11.04 9 244481 240 110344569
Feeling cold 16.70 11.04 31 244459 33956 110310853
Heat stroke 16.69 11.04 21 244469 1914 110342895
Mean cell haemoglobin concentration decreased 16.63 11.04 38 244452 5644 110339165
Tachypnoea 16.53 11.04 146 244344 39249 110305560
Delusion of reference 16.50 11.04 9 244481 246 110344563
Lipids abnormal 16.46 11.04 13 244477 672 110344137
Immunosuppressant drug level increased 16.45 11.04 3 244487 11721 110333088
Cushingoid 16.43 11.04 3 244487 11709 110333100
Infertility male 16.40 11.04 7 244483 109 110344700
Snoring 16.25 11.04 42 244448 6742 110338067
Slow response to stimuli 16.24 11.04 21 244469 1967 110342842
Blood potassium decreased 16.24 11.04 63 244427 54051 110290758
Clinodactyly 16.21 11.04 5 244485 28 110344781
Amino acid level increased 16.20 11.04 14 244476 822 110343987
Psychomotor disadaptation syndrome 16.18 11.04 7 244483 113 110344696
Gambling disorder 16.14 11.04 22 244468 2169 110342640
Malignant catatonia 16.12 11.04 13 244477 693 110344116
Impulse-control disorder 16.11 11.04 22 244468 2172 110342637
Pustular psoriasis 16.11 11.04 5 244485 13600 110331209
Squamous cell carcinoma of skin 16.06 11.04 9 244481 17194 110327615
Cholangitis 16.06 11.04 8 244482 16327 110328482
Cyclothymic disorder 16.05 11.04 9 244481 260 110344549
Lumbosacral radiculoplexus neuropathy 16.01 11.04 7 244483 116 110344693
Eye pruritus 16.01 11.04 30 244460 32745 110312064
Cerebral arteriosclerosis 15.97 11.04 14 244476 838 110343971
Near drowning 15.94 11.04 6 244484 66 110344743
Metabolic alkalosis 15.91 11.04 37 244453 5558 110339251
Dermatitis 15.91 11.04 23 244467 27814 110316995
Chronic kidney disease 15.88 11.04 101 244389 76190 110268619
Anosmia 15.85 11.04 4 244486 12468 110332341
Hepatomegaly 15.81 11.04 91 244399 21323 110323486
Appendicitis 15.80 11.04 24 244466 28440 110316369
Duodenal ulcer 15.79 11.04 12 244478 19502 110325307
Visuospatial deficit 15.78 11.04 5 244485 31 110344778
Haematotoxicity 15.77 11.04 14 244476 21068 110323741
Cholinergic syndrome 15.75 11.04 17 244473 1315 110343494
Middle insomnia 15.71 11.04 88 244402 20414 110324395
Sexual dysfunction 15.70 11.04 48 244442 8482 110336327
Lip erosion 15.70 11.04 20 244470 1846 110342963
Feminisation acquired 15.65 11.04 5 244485 32 110344777
Granuloma skin 15.59 11.04 3 244487 11280 110333529
Hypoxic-ischaemic encephalopathy 15.56 11.04 49 244441 8798 110336011
Cardiac steatosis 15.54 11.04 6 244484 71 110344738
Congenital foot malformation 15.52 11.04 5 244485 33 110344776
Congenital renal disorder 15.48 11.04 4 244486 10 110344799
Therapeutic response shortened 15.42 11.04 26 244464 29557 110315252
Idiosyncratic drug reaction 15.42 11.04 18 244472 1518 110343291
Pupillary reflex impaired 15.41 11.04 30 244460 3985 110340824
Breast cancer metastatic 15.39 11.04 3 244487 11178 110333631
Haemorrhage 15.39 11.04 156 244334 106536 110238273
Parkinson's disease 15.39 11.04 18 244472 1521 110343288
Alanine aminotransferase increased 15.39 11.04 523 243967 183250 110161559
Bronchospasm 15.38 11.04 27 244463 30212 110314597
Rotator cuff syndrome 15.38 11.04 9 244481 16785 110328024
Drug screen false positive 15.37 11.04 17 244473 1352 110343457
Diabetic encephalopathy 15.35 11.04 3 244487 0 110344809
Pyruvate carboxylase deficiency 15.35 11.04 3 244487 0 110344809
Congenital eyelid malformation 15.35 11.04 3 244487 0 110344809
Nasopharyngeal reflux 15.35 11.04 3 244487 0 110344809
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.35 11.04 3 244487 0 110344809
Retrognathia 15.35 11.04 3 244487 0 110344809
Social (pragmatic) communication disorder 15.35 11.04 3 244487 0 110344809
Lisfranc fracture 15.35 11.04 3 244487 0 110344809
Compulsive sexual behaviour 15.33 11.04 9 244481 284 110344525
Tooth disorder 15.32 11.04 26 244464 29483 110315326
Dysphemia 15.30 11.04 30 244460 4007 110340802
Diabetic hyperosmolar coma 15.28 11.04 14 244476 888 110343921
Sarcopenia 15.25 11.04 16 244474 1198 110343611
Restless legs syndrome 15.25 11.04 100 244390 24526 110320283
Tendon rupture 15.25 11.04 6 244484 14072 110330737
Pulmonary eosinophilia 15.22 11.04 13 244477 751 110344058
Oral pain 15.20 11.04 38 244452 37406 110307403
Diffusion-weighted brain MRI abnormal 15.14 11.04 5 244485 36 110344773
Myelocyte count increased 15.12 11.04 14 244476 900 110343909
Dementia with Lewy bodies 15.12 11.04 15 244475 1051 110343758
Multiple injuries 15.10 11.04 28 244462 3586 110341223
Ileus 15.09 11.04 118 244372 30611 110314198
Personality change 15.03 11.04 56 244434 10946 110333863
Dermatitis contact 15.03 11.04 6 244484 13947 110330862
Pharyngeal swelling 15.02 11.04 4 244486 12028 110332781
Osteomyelitis 14.97 11.04 37 244453 36563 110308246
Gastric ulcer 14.96 11.04 42 244448 39785 110305024
Eyelid myoclonus 14.95 11.04 7 244483 137 110344672
Prognathism 14.95 11.04 4 244486 12 110344797
Locomotive syndrome 14.95 11.04 4 244486 12 110344797
Amino acid metabolism disorder 14.95 11.04 4 244486 12 110344797
Delusional perception 14.94 11.04 10 244480 399 110344410
Autoimmune hepatitis 14.93 11.04 7 244483 14797 110330012
Muscle spasticity 14.93 11.04 36 244454 35879 110308930
Hippocampal sclerosis 14.92 11.04 8 244482 211 110344598
Microstomia 14.91 11.04 5 244485 38 110344771
Gingival atrophy 14.90 11.04 6 244484 80 110344729
Therapeutic response unexpected 14.87 11.04 97 244393 23746 110321063
Hypercalcaemia 14.86 11.04 53 244437 46604 110298205
Generalised anxiety disorder 14.85 11.04 24 244466 2755 110342054
Conversion disorder 14.81 11.04 22 244468 2348 110342461
Lacrimal gland enlargement 14.80 11.04 5 244485 39 110344770
Gastrointestinal necrosis 14.78 11.04 40 244450 6600 110338209
Feeling guilty 14.71 11.04 14 244476 932 110343877
Muscle tone disorder 14.69 11.04 8 244482 218 110344591
Temperature regulation disorder 14.68 11.04 5 244485 12821 110331988
Somnambulism 14.67 11.04 39 244451 6366 110338443
Cardiac failure acute 14.66 11.04 19 244471 24059 110320750
Urine sodium increased 14.65 11.04 8 244482 219 110344590
Sleep disorder 14.60 11.04 331 244159 198313 110146496
Skin burning sensation 14.59 11.04 16 244474 21809 110323000
Executive dysfunction 14.59 11.04 10 244480 415 110344394
Eosinophil count increased 14.59 11.04 88 244402 20970 110323839
Illusion 14.55 11.04 20 244470 1987 110342822
Acute graft versus host disease in skin 14.54 11.04 3 244487 10737 110334072
Glaucoma 14.52 11.04 17 244473 22500 110322309
Coma blister 14.49 11.04 8 244482 224 110344585
Hypophagia 14.47 11.04 179 244311 52447 110292362
Urine calcium/creatinine ratio increased 14.46 11.04 7 244483 148 110344661
Musculoskeletal chest pain 14.45 11.04 26 244464 28821 110315988
Diverticulum intestinal 14.44 11.04 4 244486 11715 110333094
Eosinophilic granulomatosis with polyangiitis 14.43 11.04 3 244487 10683 110334126
Joint dislocation 14.43 11.04 34 244456 34156 110310653
MELAS syndrome 14.37 11.04 9 244481 320 110344489
Tooth malformation 14.33 11.04 7 244483 151 110344658
Pancreatic pseudocyst 14.31 11.04 18 244472 1640 110343169
Urinary retention 14.29 11.04 225 244265 69458 110275351
Protein total increased 14.28 11.04 32 244458 4692 110340117
Cytomegalovirus viraemia 14.28 11.04 11 244479 17753 110327056
Mastication disorder 14.27 11.04 27 244463 3511 110341298
Delusional disorder, mixed type 14.27 11.04 4 244486 15 110344794
Body mass index decreased 14.21 11.04 13 244477 823 110343986
Anisometropia 14.20 11.04 6 244484 91 110344718
Glioblastoma multiforme 14.19 11.04 17 244473 1473 110343336
Factor XIII deficiency 14.14 11.04 6 244484 92 110344717
Electrocardiogram abnormal 14.14 11.04 80 244410 18629 110326180
Pathogen resistance 14.13 11.04 11 244479 17661 110327148
Oesophageal carcinoma 14.07 11.04 4 244486 11520 110333289
Metamyelocyte count increased 14.04 11.04 12 244478 694 110344115
Cross sensitivity reaction 13.89 11.04 35 244455 5532 110339277
High arched palate 13.89 11.04 5 244485 48 110344761
Ejaculation disorder 13.86 11.04 11 244479 573 110344236
Haematuria 13.86 11.04 117 244373 82888 110261921
Product selection error 13.86 11.04 10 244480 451 110344358
Intestinal dilatation 13.84 11.04 27 244463 3593 110341216
Wrong schedule 13.83 11.04 12 244478 708 110344101
Dependence 13.81 11.04 23 244467 2706 110342103
Hepatitis fulminant 13.78 11.04 46 244444 8514 110336295
Pneumonia bacterial 13.76 11.04 23 244467 26238 110318571
Proctalgia 13.73 11.04 6 244484 13216 110331593
Infusion site pain 13.73 11.04 11 244479 17408 110327401
Vitamin B6 decreased 13.70 11.04 5 244485 50 110344759
Libido increased 13.66 11.04 22 244468 2517 110342292
Vitamin B6 deficiency 13.66 11.04 11 244479 585 110344224
Gastrostomy 13.65 11.04 17 244473 1533 110343276
Spinal fracture 13.64 11.04 18 244472 22615 110322194
Disability 13.62 11.04 29 244461 30194 110314615
Lower motor neurone lesion 13.53 11.04 5 244485 52 110344757
Painful ejaculation 13.53 11.04 6 244484 103 110344706
Fall 13.52 11.04 1528 242962 601954 109742855
Sperm concentration decreased 13.48 11.04 6 244484 104 110344705
Urine output increased 13.46 11.04 23 244467 2763 110342046
Blood citric acid increased 13.45 11.04 5 244485 53 110344756
Angina unstable 13.43 11.04 10 244480 16422 110328387
Constipation 13.43 11.04 650 243840 357136 109987673
Ankylosing spondylitis 13.42 11.04 9 244481 15603 110329206
Pneumonia viral 13.39 11.04 4 244486 11153 110333656
Blood bicarbonate increased 13.34 11.04 16 244474 1388 110343421
Drug level therapeutic 13.28 11.04 3 244487 3 110344806
Congenital scoliosis 13.28 11.04 3 244487 3 110344806
Congenital hypothyroidism 13.28 11.04 3 244487 3 110344806
False positive investigation result 13.25 11.04 16 244474 1398 110343411
Attention-seeking behaviour 13.22 11.04 6 244484 109 110344700
Echopraxia 13.20 11.04 5 244485 56 110344753
Limb injury 13.19 11.04 41 244449 37595 110307214
Herbal interaction 13.19 11.04 11 244479 615 110344194
Phlebitis superficial 13.10 11.04 11 244479 621 110344188
Myositis 13.08 11.04 31 244459 31085 110313724
Systemic candida 13.07 11.04 3 244487 9971 110334838
Rotavirus infection 13.07 11.04 13 244477 914 110343895
Pain of skin 13.04 11.04 15 244475 20014 110324795
Laryngomalacia 13.03 11.04 4 244486 22 110344787
Lower gastrointestinal haemorrhage 12.98 11.04 13 244477 18473 110326336
SARS-CoV-2 test positive 12.97 11.04 11 244479 16924 110327885
Altered visual depth perception 12.92 11.04 10 244480 502 110344307
Hydronephrosis 12.90 11.04 16 244474 20649 110324160
Malignant melanoma 12.90 11.04 11 244479 16880 110327929
Bipolar II disorder 12.88 11.04 10 244480 504 110344305
Intraocular pressure increased 12.87 11.04 4 244486 10872 110333937
Respiratory distress 12.87 11.04 219 244271 68655 110276154
Brain herniation 12.85 11.04 46 244444 8817 110335992
Holmes tremor 12.82 11.04 3 244487 4 110344805
Food refusal 12.80 11.04 13 244477 937 110343872
Respiratory tract congestion 12.77 11.04 31 244459 30826 110313983
Arthritis bacterial 12.77 11.04 4 244486 10816 110333993
Prescribed overdose 12.75 11.04 268 244222 87313 110257496
Electrocardiogram J wave abnormal 12.74 11.04 4 244486 24 110344785
Device occlusion 12.72 11.04 9 244481 15176 110329633
Incorrect product administration duration 12.66 11.04 16 244474 20482 110324327
Rales 12.66 11.04 22 244468 24717 110320092
Blood insulin increased 12.65 11.04 9 244481 397 110344412
Nephrolithiasis 12.61 11.04 90 244400 66122 110278687
Idiopathic generalised epilepsy 12.60 11.04 5 244485 64 110344745
CSF white blood cell count positive 12.60 11.04 4 244486 25 110344784
Orthostatic tremor 12.60 11.04 4 244486 25 110344784
Seasonal allergy 12.60 11.04 15 244475 19707 110325102
Waxy flexibility 12.58 11.04 8 244482 292 110344517
Labelled drug-food interaction issue 12.56 11.04 6 244484 123 110344686
Decreased appetite 12.56 11.04 894 243596 474952 109869857
Retrograde ejaculation 12.55 11.04 9 244481 402 110344407
Aphthous ulcer 12.54 11.04 17 244473 21119 110323690
Electrocardiogram QT shortened 12.54 11.04 8 244482 294 110344515
Organising pneumonia 12.53 11.04 8 244482 14235 110330574
Selective eating disorder 12.51 11.04 8 244482 295 110344514
Arthropod bite 12.49 11.04 3 244487 9668 110335141
Tubo-ovarian abscess 12.49 11.04 9 244481 405 110344404
Endocarditis 12.48 11.04 7 244483 13364 110331445
Acidosis 12.47 11.04 89 244401 22442 110322367
Symptom masked 12.43 11.04 18 244472 1877 110342932
Prominent epicanthal folds 12.42 11.04 3 244487 5 110344804
Poor venous access 12.37 11.04 22 244468 24500 110320309
Cyst 12.29 11.04 11 244479 16485 110328324
Fear-related avoidance of activities 12.26 11.04 6 244484 130 110344679
Mitochondrial enzyme deficiency 12.21 11.04 4 244486 28 110344781
Synovial cyst 12.17 11.04 5 244485 11425 110333384
Heparin-induced thrombocytopenia 12.16 11.04 5 244485 11419 110333390
Granuloma 12.15 11.04 3 244487 9487 110335322
Hypocalcaemic seizure 12.14 11.04 6 244484 133 110344676
Histiocytic necrotising lymphadenitis 12.13 11.04 5 244485 71 110344738
Monocytosis 12.11 11.04 17 244473 1723 110343086
Schizoaffective disorder depressive type 12.09 11.04 4 244486 29 110344780
Lymphocyte morphology abnormal 12.08 11.04 13 244477 1002 110343807
Drug half-life reduced 12.07 11.04 3 244487 6 110344803
Hippocampal atrophy 12.07 11.04 3 244487 6 110344803
Congenital renal cyst 12.07 11.04 3 244487 6 110344803
Urine cannabinoids increased 12.07 11.04 3 244487 6 110344803
Derealisation 12.03 11.04 19 244471 2139 110342670
End stage renal disease 12.02 11.04 18 244472 21455 110323354
Skin irritation 12.01 11.04 11 244479 16308 110328501
Cell death 12.01 11.04 34 244456 5757 110339052
Diverticulum 11.99 11.04 10 244480 15516 110329293
Weight fluctuation 11.98 11.04 19 244471 22126 110322683
Embolism 11.97 11.04 11 244479 16278 110328531
Diet refusal 11.96 11.04 12 244478 852 110343957
Abortion induced 11.96 11.04 42 244448 7977 110336832
Aortic stenosis 11.95 11.04 7 244483 13052 110331757
Cardiomyopathy 11.94 11.04 120 244370 33405 110311404
Poriomania 11.92 11.04 7 244483 221 110344588
Spinal pain 11.91 11.04 14 244476 18501 110326308
Dysuria 11.90 11.04 81 244409 60150 110284659
Acute pulmonary oedema 11.88 11.04 12 244478 16984 110327825
Blood albumin decreased 11.87 11.04 103 244387 27549 110317260
Ventricular septal defect 11.87 11.04 11 244479 708 110344101
Therapeutic hypothermia 11.86 11.04 4 244486 31 110344778
Tooth extraction 11.84 11.04 7 244483 12984 110331825
Cytotoxic oedema 11.83 11.04 9 244481 440 110344369
Cardiac failure chronic 11.82 11.04 8 244482 13803 110331006
Post procedural infection 11.82 11.04 8 244482 13801 110331008
Dependence on oxygen therapy 11.82 11.04 11 244479 712 110344097
Leukaemia 11.75 11.04 40 244450 7478 110337331
Peripheral arterial occlusive disease 11.75 11.04 3 244487 9277 110335532
Pleuritic pain 11.74 11.04 11 244479 16129 110328680
Tension 11.71 11.04 31 244459 5047 110339762
Scrotal haematoma 11.71 11.04 5 244485 78 110344731
Legal problem 11.67 11.04 6 244484 145 110344664
Drug dose omission by device 11.65 11.04 9 244481 14507 110330302
Influenza like illness 11.65 11.04 132 244358 88280 110256529
Mesenteric vascular occlusion 11.59 11.04 5 244485 80 110344729
Coma acidotic 11.59 11.04 6 244484 147 110344662
Left ventricular dilatation 11.58 11.04 15 244475 1407 110343402
Medication error 11.55 11.04 310 244180 105056 110239753
Eye inflammation 11.54 11.04 3 244487 9168 110335641
Monocyte count decreased 11.54 11.04 26 244464 3825 110340984
Illiteracy 11.54 11.04 4 244486 34 110344775
Aspartate aminotransferase decreased 11.53 11.04 15 244475 1413 110343396
Adverse drug reaction 11.53 11.04 164 244326 105395 110239414
Pulmonary tuberculosis 11.48 11.04 3 244487 9136 110335673
Self esteem decreased 11.45 11.04 13 244477 1064 110343745
Hypercapnia 11.45 11.04 52 244438 11107 110333702
Pelvic pain 11.44 11.04 11 244479 15931 110328878
Mass 11.43 11.04 16 244474 19614 110325195
Gastric cancer 11.42 11.04 5 244485 11003 110333806
Patient elopement 11.42 11.04 8 244482 344 110344465
Device use error 11.39 11.04 3 244487 9086 110335723
PCO2 decreased 11.39 11.04 23 244467 3138 110341671
Blood bicarbonate abnormal 11.38 11.04 6 244484 153 110344656
Drowning 11.37 11.04 12 244478 905 110343904
Encephalitis 11.36 11.04 76 244414 18763 110326046
Dermatitis bullous 11.36 11.04 72 244418 17457 110327352
Vanishing bile duct syndrome 11.35 11.04 23 244467 3145 110341664
Hyperthermia malignant 11.32 11.04 26 244464 3874 110340935
Full blood count abnormal 11.26 11.04 75 244415 55977 110288832
Vasculitis 11.26 11.04 41 244449 35832 110308977
Platelet count increased 11.26 11.04 98 244392 26236 110318573
Mitral valve thickening 11.24 11.04 11 244479 758 110344051
Energy increased 11.23 11.04 25 244465 3649 110341160
Decreased activity 11.15 11.04 51 244439 10923 110333886
Postoperative wound infection 11.15 11.04 11 244479 15742 110329067
Toothache 11.15 11.04 22 244468 23553 110321256
Visual field defect 11.14 11.04 48 244442 10024 110334785
Cerebellar ataxia 11.11 11.04 18 244472 2070 110342739
Lip swelling 11.11 11.04 66 244424 50601 110294208
Body temperature decreased 11.08 11.04 43 244447 36892 110307917
Lipase increased 11.07 11.04 75 244415 18597 110326212
Hepatocellular carcinoma 11.05 11.04 4 244486 9876 110334933
Respiratory tract infection 11.05 11.04 103 244387 71514 110273295
Metastases to central nervous system 11.04 11.04 21 244469 22796 110322013

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal anticonvulsant syndrome 159.07 22.33 41 852 0 113060
Congenital nose malformation 61.85 22.33 16 877 0 113060
Low set ears 45.42 22.33 15 878 20 113040
Dysmorphism 40.49 22.33 32 861 452 112608
Exposure during pregnancy 25.58 22.33 41 852 1312 111748
High arched palate 23.16 22.33 6 887 0 113060
Hypertelorism 22.46 22.33 10 883 42 113018

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018692 Antimanic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35477 antimanic drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:51374 GABA agent
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:61115 EC 3.5.1.98 (histone deacetylase) inhibitor
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:35471 psychotropic drug
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:50905 teratogenic agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:73336 vulnerary

Related Drugs by ATC class:

N03AG Fatty acid derivatives 5 drugs
aminobutyric acidprogabidetiagabinevalpromidevigabatrin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase-related protein 1 Enzyme IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
1069-66-5 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL433 ChEMBL_ID
D014635 MESH_DESCRIPTOR_UI
3121 PUBCHEM_CID
3300 INN_ID
7009 IUPHAR_LIGAND_ID
614OI1Z5WI UNII
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
390136 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
433011000221103 SNOMEDCT_US
5641004 SNOMEDCT_US
CHEMBL2315212 ChEMBL_ID
33433-82-8 SECONDARY_CAS_RN
5132 INN_ID
614OI1Z5WI INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 32 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 33 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 32 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7326 TABLET, DELAYED RELEASE 250 mg ORAL NDA 32 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 32 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 32 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 32 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0116-4021 SOLUTION 250 mg ORAL ANDA 20 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 30 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 30 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 30 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 30 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 30 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 30 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 30 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0591-4012 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 29 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8205 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 23 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8237 CAPSULE 125 mg ORAL ANDA 27 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8376 TABLET, EXTENDED RELEASE 250 mg ORAL ANDA 27 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8377 TABLET, EXTENDED RELEASE 500 mg ORAL ANDA 27 sections
divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8586 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 26 sections
divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8587 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 26 sections
divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8588 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 26 sections
valproic acid HUMAN PRESCRIPTION DRUG LABEL 1 0832-0310 CAPSULE 250 mg ORAL ANDA 30 sections