aminobutyric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1262 | 56-12-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The most common inhibitory neurotransmitter in the central nervous system.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
| 1 | g | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N03AG03 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Fatty acid derivatives |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| CHEBI has role | CHEBI:25512 | neurotransmitters |
| CHEBI has role | CHEBI:62488 | signal molecules |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.87 | acidic |
| pKa2 | 10.45 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium- and chloride-dependent GABA transporter 1 | Transporter | IC50 | 5.30 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit rho-1 | Ion channel | EC50 | 6.57 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 3 | Transporter | IC50 | 5.15 | CHEMBL | |||||
| Sodium- and chloride-dependent betaine transporter | Transporter | IC50 | 4.44 | CHEMBL | |||||
| Platelet glycoprotein VI | Unclassified | Kd | 7.39 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 2 | Transporter | IC50 | 4.58 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | IC50 | 7.66 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 1 | Transporter | IC50 | 5.59 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 1 | Transporter | IC50 | 5.14 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | EC50 | 5 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 3 | Transporter | IC50 | 5.09 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 2 | Transporter | IC50 | 5.30 | CHEMBL | |||||
| Sodium- and chloride-dependent GABA transporter 2 | Transporter | IC50 | 4.56 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit gamma-1 | Ion channel | IC50 | 7.48 | CHEMBL | |||||
| Gamma-aminobutyric acid type B receptor subunit 1 | GPCR | AGONIST | IC50 | 4.60 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4034308 | VUID |
| N0000191506 | NUI |
| 4034308 | VANDF |
| C0220780 | UMLSCUI |
| CHEBI:16865 | CHEBI |
| ABU | PDB_CHEM_ID |
| CHEMBL96 | ChEMBL_ID |
| D000613 | MESH_DESCRIPTOR_UI |
| 1067 | IUPHAR_LIGAND_ID |
| 119 | PUBCHEM_CID |
| DB02530 | DRUGBANK_ID |
| 4617 | RXNORM |
| 006466 | NDDF |
| 259100002 | SNOMEDCT_US |
| D005680 | MESH_DESCRIPTOR_UI |
| 2ACZ6IPC6I | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dairy Allergen Mix | HUMAN OTC DRUG LABEL | 38 | 43742-1277 | LIQUID | 8 [hp_X] | ORAL | unapproved drug other | 9 sections |
| Gongjinhyang Qi and Jin Eye | HUMAN OTC DRUG LABEL | 1 | 53208-500 | CREAM | 0.02 mL | TOPICAL | unapproved drug other | 10 sections |