valpromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2804 | 2430-27-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 68 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Poisoning deliberate | 126.52 | 56.72 | 31 | 1081 | 11187 | 63476723 |
| Coma | 119.20 | 56.72 | 44 | 1068 | 64320 | 63423590 |
| Suicide attempt | 68.19 | 56.72 | 29 | 1083 | 60889 | 63427021 |
| Bradycardia | 66.23 | 56.72 | 30 | 1082 | 73197 | 63414713 |
| Alkalosis hypochloraemic | 63.33 | 56.72 | 9 | 1103 | 158 | 63487752 |
| Toxicity to various agents | 60.72 | 56.72 | 43 | 1069 | 247207 | 63240703 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Meningioma | 87.22 | 61.36 | 16 | 608 | 1420 | 34954887 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Poisoning deliberate | 143.61 | 52.73 | 40 | 1717 | 18788 | 79723843 |
| Coma | 102.41 | 52.73 | 48 | 1709 | 100601 | 79642030 |
| Hypothermia | 69.51 | 52.73 | 24 | 1733 | 22722 | 79719909 |
| Suicide attempt | 64.60 | 52.73 | 33 | 1724 | 82899 | 79659732 |
| Hypometabolism | 55.02 | 52.73 | 8 | 1749 | 130 | 79742501 |
| Toxicity to various agents | 54.53 | 52.73 | 56 | 1701 | 421484 | 79321147 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N03AG02 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Fatty acid derivatives |
| MeSH PA | D000927 | Anticonvulsants |
| MeSH PA | D002491 | Central Nervous System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.58 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02766 | KEGG_DRUG |
| 1116-24-1 | SECONDARY_CAS_RN |
| C0058426 | UMLSCUI |
| VPR | PDB_CHEM_ID |
| CHEMBL93836 | ChEMBL_ID |
| DB04165 | DRUGBANK_ID |
| 71113 | PUBCHEM_CID |
| 4365 | INN_ID |
| C004651 | MESH_SUPPLEMENTAL_RECORD_UI |
| RUA6CWU76G | UNII |
| 23420 | RXNORM |
| 005370 | NDDF |
| 698808002 | SNOMEDCT_US |
Pharmaceutical products:
None