valpromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2804 2430-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valpromide
  • 2-propylpentamide
  • dipropylacetamide
  • Molecular weight: 143.23
  • Formula: C8H17NO
  • CLOGP: 1.84
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 43.09
  • ALOGS: -1.61
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 68 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 117.87 60.66 44 992 56835 50547253
Poisoning deliberate 116.81 60.66 28 1008 7884 50596204
Alkalosis hypochloraemic 63.32 60.66 9 1027 134 50603954

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Meningioma 86.53 62.54 16 575 1324 29572612
Hypometabolism 62.64 62.54 8 583 51 29573885

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 136.79 47.92 37 1614 13421 64483660
Coma 101.93 47.92 48 1603 87567 64409514
Hypometabolism 58.29 47.92 8 1643 71 64497010
Hypothermia 57.78 47.92 21 1630 19835 64477246
Suicide attempt 53.37 47.92 29 1622 70978 64426103
Alkalosis hypochloraemic 50.79 47.92 9 1642 451 64496630
Toxicity to various agents 49.10 47.92 53 1598 363460 64133621

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.58 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02766 KEGG_DRUG
1116-24-1 SECONDARY_CAS_RN
C0058426 UMLSCUI
VPR PDB_CHEM_ID
CHEMBL93836 ChEMBL_ID
DB04165 DRUGBANK_ID
71113 PUBCHEM_CID
4365 INN_ID
C004651 MESH_SUPPLEMENTAL_RECORD_UI
RUA6CWU76G UNII
23420 RXNORM
005370 NDDF
698808002 SNOMEDCT_US

Pharmaceutical products:

None