valpromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2804 2430-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valpromide
  • 2-propylpentamide
  • dipropylacetamide
  • Molecular weight: 143.23
  • Formula: C8H17NO
  • CLOGP: 1.84
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 43.09
  • ALOGS: -1.61
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 79 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 54
kinase-selectivity-class AXL,GRK2,PDK4 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 157.55 63.42 53 1242 72579 90554573
Poisoning deliberate 135.73 63.42 34 1261 16452 90610700
Toxicity to various agents 77.31 63.42 49 1246 287797 90339355
Suicide attempt 74.57 63.42 31 1264 75368 90551784
Bradycardia 71.40 63.42 31 1264 83816 90543336

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 89.20 52.75 24 899 10110 42610302
Meningioma 81.12 52.75 16 907 1711 42618701
Altered state of consciousness 75.32 52.75 27 896 29232 42591180
Somnolence 74.64 52.75 43 880 141062 42479350
Hypometabolism 53.10 52.75 8 915 171 42620241

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 215.66 50.08 58 2166 26273 110560802
Coma 180.71 50.08 73 2151 117796 110469279
Wrong patient received product 80.30 50.08 20 2204 6654 110580421
Hypothermia 75.95 50.08 26 2198 26276 110560799
Somnolence 71.32 50.08 54 2170 297395 110289680
Altered state of consciousness 68.96 50.08 30 2194 57596 110529479
Suicide attempt 66.14 50.08 35 2189 103359 110483716
Toxicity to various agents 63.53 50.08 62 2162 480493 110106582
Hypotension 62.65 50.08 64 2160 523785 110063290
Hypometabolism 53.15 50.08 8 2216 183 110586892
Hepatocellular injury 52.97 50.08 24 2200 50618 110536457
Alkalosis hypochloraemic 50.55 50.08 9 2215 592 110586483

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50905 teratogenic agent
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

N03AG Fatty acid derivatives 5 drugs
aminobutyric acidprogabidetiagabinevalproic acidvigabatrin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.58 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02766 KEGG_DRUG
1116-24-1 SECONDARY_CAS_RN
C0058426 UMLSCUI
VPR PDB_CHEM_ID
CHEMBL93836 ChEMBL_ID
DB04165 DRUGBANK_ID
71113 PUBCHEM_CID
4365 INN_ID
C004651 MESH_SUPPLEMENTAL_RECORD_UI
RUA6CWU76G UNII
23420 RXNORM
005370 NDDF
698808002 SNOMEDCT_US
CHEBI:46316 CHEBI

Pharmaceutical products:

None