valpromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2804	2430-27-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: valpromide 2-propylpentamide dipropylacetamide	Molecular weight: 143.23 Formula: C8H17NO CLOGP: 1.84 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 43.09 ALOGS: -1.61 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

valpromide
2-propylpentamide
dipropylacetamide

Molecular weight: 143.23
Formula: C8H17NO
CLOGP: 1.84
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 43.09
ALOGS: -1.61
ROTB: 5

Drug dosage:

Dose	Unit	Route
1.50	g	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	68 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Poisoning deliberate	126.52	56.72	31	1081	11187	63476723
Coma	119.20	56.72	44	1068	64320	63423590
Suicide attempt	68.19	56.72	29	1083	60889	63427021
Bradycardia	66.23	56.72	30	1082	73197	63414713
Alkalosis hypochloraemic	63.33	56.72	9	1103	158	63487752
Toxicity to various agents	60.72	56.72	43	1069	247207	63240703

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Meningioma	87.22	61.36	16	608	1420	34954887

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Poisoning deliberate	143.61	52.73	40	1717	18788	79723843
Coma	102.41	52.73	48	1709	100601	79642030
Hypothermia	69.51	52.73	24	1733	22722	79719909
Suicide attempt	64.60	52.73	33	1724	82899	79659732
Hypometabolism	55.02	52.73	8	1749	130	79742501
Toxicity to various agents	54.53	52.73	56	1701	421484	79321147

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N03AG02	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Fatty acid derivatives
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.58	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
VPR	PDB_CHEM_ID
005370	NDDF
1116-24-1	SECONDARY_CAS_RN
23420	RXNORM
4365	INN_ID
698808002	SNOMEDCT_US
71113	PUBCHEM_CID
C004651	MESH_SUPPLEMENTAL_RECORD_UI
C0058426	UMLSCUI
CHEMBL93836	ChEMBL_ID

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Pharmaceutical products:

None