progabide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
gabamimetic agents	2278	62666-20-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

progabide
halogabide
gabrene
gabren

GABA agonist; structure

Molecular weight: 334.78
Formula: C17H16ClFN2O2
CLOGP: 2.90
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 75.68
ALOGS: -4.68
ROTB: 6

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1985	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N03AG05	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Fatty acid derivatives
MeSH PA	D018726	Anti-Dyskinesia Agents
MeSH PA	D000927	Anticonvulsants
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000978	Antiparkinson Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018755	GABA Agonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.28	acidic
pKa2	13.0	acidic
pKa3	3.38	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN		Ki	4.40		WOMBAT-PK
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN		Ki	4.40		CHEMBL
GABA-A receptor; anion channel	Ion channel		GBRP_RAT GBRB1_RAT GBRD_RAT GBRG2_RAT GBRA5_RAT GBRA3_RAT GBRG1_RAT GBRA2_RAT GBRA4_RAT GBRG3_RAT GBRA6_RAT GBRA1_RAT GBRB3_RAT GBRB2_RAT Q91ZM7_RAT GBRE_RAT		Ki	4.85		CHEMBL

External reference:

ID	Source
D05621	KEGG_DRUG
C0072076	UMLSCUI
CHEBI:135422	CHEBI
CHEMBL287631	ChEMBL_ID
DB00837	DRUGBANK_ID
C017985	MESH_SUPPLEMENTAL_RECORD_UI
44115	PUBCHEM_CID
4656	INN_ID
38C836J57Z	UNII
34568	RXNORM
005334	NDDF

Pharmaceutical products:

None