valproic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • epival
  • divalproex sodium
  • depakote
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2136.45 10.60 1895 115371 123224 56051577
Epilepsy 1253.13 10.60 733 116533 24498 56150303
Hyperammonaemia 1171.11 10.60 426 116840 4514 56170287
Drug interaction 1122.56 10.60 1750 115516 208005 55966796
Hyperammonaemic encephalopathy 1080.02 10.60 328 116938 1857 56172944
Status epilepticus 1049.21 10.60 548 116718 14593 56160208
Rheumatoid arthritis 695.05 10.60 23 117243 382581 55792220
Somnolence 660.55 10.60 1204 116062 162209 56012592
Foetal anticonvulsant syndrome 649.87 10.60 165 117101 407 56174394
Toxicity to various agents 575.55 10.60 1372 115894 223192 55951609
Aggression 550.12 10.60 417 116849 21589 56153212
Sopor 537.51 10.60 403 116863 20519 56154282
Generalised tonic-clonic seizure 536.59 10.60 451 116815 27115 56147686
Pain 516.65 10.60 379 116887 662805 55511996
Multiple-drug resistance 510.06 10.60 220 117046 3754 56171047
Arthralgia 504.30 10.60 208 117058 501461 55673340
Intentional overdose 483.74 10.60 651 116615 67466 56107335
Dysmorphism 477.07 10.60 178 117088 2035 56172766
Psychotic disorder 465.89 10.60 389 116877 23169 56151632
Foetal exposure during pregnancy 444.37 10.60 444 116822 33379 56141422
Ammonia increased 441.43 10.60 204 117062 4125 56170676
Mania 439.58 10.60 283 116983 11237 56163564
Coma 421.80 10.60 569 116697 59086 56115715
Drug level increased 417.66 10.60 346 116920 20379 56154422
Overdose 417.28 10.60 772 116494 105058 56069743
Extrapyramidal disorder 416.70 10.60 281 116985 12075 56162726
Joint swelling 401.85 10.60 62 117204 289738 55885063
Petit mal epilepsy 397.57 10.60 179 117087 3399 56171402
Tremor 385.03 10.60 807 116459 120282 56054519
Drug abuse 378.34 10.60 577 116689 67033 56107768
Intentional self-injury 369.36 10.60 350 116916 24642 56150159
Granulocytopenia 354.66 10.60 188 117078 5156 56169645
Suicide attempt 347.01 10.60 510 116756 57326 56117475
Neuroleptic malignant syndrome 346.89 10.60 244 117022 11234 56163567
Speech disorder developmental 338.71 10.60 101 117165 531 56174270
Infusion related reaction 331.13 10.60 28 117238 208903 55965898
Parkinsonism 328.85 10.60 220 117046 9326 56165475
Arthropathy 316.94 10.60 27 117239 200248 55974553
Sedation 313.70 10.60 375 116891 34479 56140322
Fatigue 311.29 10.60 746 116520 787806 55386995
Abnormal behaviour 294.03 10.60 281 116985 19991 56154810
Agitation 290.81 10.60 462 116804 55574 56119227
Developmental delay 290.80 10.60 109 117157 1263 56173538
Abdominal discomfort 287.79 10.60 109 117157 277165 55897636
Schizoaffective disorder 285.27 10.60 134 117132 2815 56171986
Dyspnoea 280.35 10.60 505 116761 592072 55582729
Swelling 273.71 10.60 80 117186 239691 55935110
Drug reaction with eosinophilia and systemic symptoms 270.98 10.60 325 116941 29979 56144822
Learning disorder 267.35 10.60 84 117182 541 56174260
Peripheral swelling 266.69 10.60 79 117187 234647 55940154
Ataxia 262.53 10.60 227 117039 14176 56160625
Depressed level of consciousness 260.05 10.60 441 116825 55992 56118809
Contraindicated product administered 259.98 10.60 39 117227 186247 55988554
Hand deformity 259.50 10.60 4 117262 134488 56040313
Electrocardiogram QT prolonged 257.41 10.60 431 116835 54157 56120644
Systemic lupus erythematosus 248.33 10.60 39 117227 180039 55994762
Glossodynia 242.67 10.60 20 117246 152438 56022363
Bipolar disorder 240.42 10.60 166 117100 7414 56167387
Cognitive disorder 239.80 10.60 394 116872 48739 56126062
Drug level decreased 231.85 10.60 158 117108 6906 56167895
Myoclonic epilepsy 231.33 10.60 88 117178 1065 56173736
Autism spectrum disorder 229.09 10.60 79 117187 705 56174096
Antipsychotic drug level increased 220.65 10.60 116 117150 3126 56171675
Salivary hypersecretion 220.33 10.60 153 117113 6897 56167904
Intellectual disability 219.59 10.60 78 117188 766 56174035
Abortion spontaneous 219.12 10.60 355 116911 43398 56131403
Diarrhoea 215.96 10.60 651 116615 637856 55536945
Anticonvulsant drug level increased 213.49 10.60 88 117178 1333 56173468
Hypernatraemia 207.66 10.60 144 117122 6476 56168325
Discomfort 204.03 10.60 27 117239 141734 56033067
Sinusitis 202.67 10.60 79 117187 197502 55977299
Disturbance in attention 200.98 10.60 291 116975 32249 56142552
Partial seizures 197.23 10.60 129 117137 5261 56169540
Nasopharyngitis 191.94 10.60 111 117155 220848 55953953
Altered state of consciousness 191.38 10.60 238 117028 22783 56152018
Encephalopathy 191.19 10.60 297 116969 35028 56139773
Drug intolerance 189.36 10.60 164 117102 264654 55910147
Hypersensitivity 184.29 10.60 158 117108 256250 55918551
Sudden unexplained death in epilepsy 183.49 10.60 54 117212 269 56174532
Hallucination, auditory 182.96 10.60 168 117098 11356 56163445
Anticonvulsant drug level above therapeutic 181.51 10.60 60 117206 464 56174337
Irritability 178.94 10.60 262 117004 29326 56145475
Fanconi syndrome 177.78 10.60 75 117191 1208 56173593
Disorientation 173.79 10.60 290 116976 36323 56138478
Anticonvulsant drug level decreased 173.58 10.60 72 117194 1109 56173692
Hypothermia 173.55 10.60 169 117097 12301 56162500
Pain in extremity 172.49 10.60 220 117046 297211 55877590
Drug ineffective for unapproved indication 172.30 10.60 239 117027 25454 56149347
Schizophrenia 170.48 10.60 155 117111 10344 56164457
Psychomotor retardation 164.82 10.60 100 117166 3569 56171232
Psychomotor skills impaired 164.19 10.60 83 117183 2057 56172744
Drug resistance 163.79 10.60 208 117058 20334 56154467
Nausea 163.38 10.60 931 116335 763247 55411554
Behaviour disorder 162.03 10.60 89 117177 2624 56172177
Treatment noncompliance 161.03 10.60 263 117003 32360 56142441
Electroencephalogram abnormal 160.37 10.60 97 117169 3442 56171359
Hypotonia 158.62 10.60 137 117129 8540 56166261
Wound 157.01 10.60 47 117219 138757 56036044
Delusion 154.22 10.60 151 117115 11064 56163737
Stevens-Johnson syndrome 152.24 10.60 211 117055 22452 56152349
Learning disability 150.86 10.60 43 117223 187 56174614
Catatonia 147.80 10.60 96 117170 3868 56170933
Drug withdrawal convulsions 144.54 10.60 66 117200 1296 56173505
Congenital nose malformation 144.26 10.60 44 117222 253 56174548
Therapeutic product effect decreased 141.67 10.60 89 117177 169363 56005438
Suicidal ideation 141.14 10.60 347 116919 57395 56117406
Myoclonus 139.09 10.60 165 117101 15038 56159763
Pruritus 137.73 10.60 283 116983 316340 55858461
Language disorder 133.66 10.60 70 117196 1871 56172930
Cough 132.13 10.60 211 117055 259750 55915051
Back pain 129.73 10.60 183 117083 236987 55937814
Educational problem 129.69 10.60 43 117223 336 56174465
Paradoxical drug reaction 129.07 10.60 87 117179 3733 56171068
Product substitution issue 127.91 10.60 155 117111 14444 56160357
Pericarditis 126.64 10.60 35 117231 108888 56065913
Completed suicide 125.53 10.60 582 116684 133251 56041550
Hypomania 124.90 10.60 94 117172 4808 56169993
Dysarthria 123.63 10.60 262 117004 39288 56135513
Psychomotor hyperactivity 123.57 10.60 126 117140 9694 56165107
Impaired healing 121.48 10.60 18 117248 86823 56087978
Exposure during pregnancy 120.66 10.60 583 116683 135759 56039042
Headache 119.74 10.60 680 116586 558364 55616437
Respiratory depression 117.14 10.60 137 117129 12298 56162503
Muscle rigidity 116.61 10.60 127 117139 10544 56164257
Meningomyelocele 116.44 10.60 45 117221 570 56174231
Bradyphrenia 115.92 10.60 102 117164 6518 56168283
Helicobacter infection 115.46 10.60 10 117256 73258 56101543
Mental disorder 113.39 10.60 188 117078 23416 56151385
Pneumonia aspiration 111.06 10.60 223 117043 32188 56142613
Congenital hand malformation 110.68 10.60 36 117230 263 56174538
Anticonvulsant drug level below therapeutic 110.12 10.60 43 117223 561 56174240
Thrombocytopenia 109.58 10.60 567 116699 135657 56039144
Psychogenic seizure 109.38 10.60 58 117208 1591 56173210
Blood creatine phosphokinase increased 108.83 10.60 203 117063 27749 56147052
Talipes 107.92 10.60 55 117211 1387 56173414
Rash 107.52 10.60 596 116670 492451 55682350
Arthritis 107.25 10.60 37 117229 99815 56074986
Tardive dyskinesia 106.47 10.60 106 117160 7925 56166876
Congenital foot malformation 106.17 10.60 33 117233 204 56174597
Infection 104.06 10.60 160 117106 200046 55974755
Akathisia 103.43 10.60 108 117158 8544 56166257
Febrile neutropenia 102.04 10.60 46 117220 105499 56069302
Focal dyscognitive seizures 101.87 10.60 67 117199 2758 56172043
Hyperprolactinaemia 101.81 10.60 74 117192 3587 56171214
Product residue present 101.67 10.60 75 117191 3720 56171081
Stomatitis 101.57 10.60 63 117203 120747 56054054
Folliculitis 100.66 10.60 3 117263 54976 56119825
Myocarditis 99.55 10.60 107 117159 8751 56166050
Injection site pain 98.56 10.60 61 117205 117057 56057744
Atonic seizures 98.12 10.60 40 117226 588 56174213
Speech disorder 97.69 10.60 231 117035 37262 56137539
Alopecia 97.47 10.60 301 116965 293157 55881644
Intentional product use issue 97.14 10.60 43 117223 99690 56075111
Cerebral atrophy 96.97 10.60 80 117186 4680 56170121
Carnitine deficiency 96.40 10.60 28 117238 132 56174669
Rhabdomyolysis 94.77 10.60 240 117026 40418 56134383
Nystagmus 94.57 10.60 86 117180 5739 56169062
Stupor 93.49 10.60 73 117193 3945 56170856
Muscle injury 92.18 10.60 4 117262 52496 56122305
Psychiatric symptom 91.63 10.60 78 117188 4766 56170035
Psoriatic arthropathy 91.38 10.60 21 117245 73987 56100814
Delirium 90.92 10.60 243 117023 42274 56132527
Herpes zoster 88.92 10.60 24 117242 75865 56098936
Dyskinesia 87.71 10.60 190 117076 28918 56145883
Musculoskeletal stiffness 86.62 10.60 119 117147 155888 56018913
Bipolar I disorder 86.20 10.60 50 117216 1640 56173161
Low set ears 85.91 10.60 29 117237 241 56174560
Osteoarthritis 85.80 10.60 30 117236 80266 56094535
Loss of consciousness 85.05 10.60 451 116815 108898 56065903
Abdominal pain upper 84.74 10.60 151 117115 178162 55996639
Plasma cell myeloma 83.78 10.60 3 117263 46643 56128158
Leukopenia 82.23 10.60 329 116937 70611 56104190
Toxic epidermal necrolysis 81.99 10.60 157 117109 21885 56152916
Hypertelorism 81.91 10.60 32 117234 418 56174383
Tonic convulsion 81.34 10.60 43 117223 1172 56173629
Persecutory delusion 80.83 10.60 56 117210 2514 56172287
Urticaria 80.67 10.60 110 117156 144566 56030235
Neuropathy peripheral 80.63 10.60 58 117208 102835 56071966
Lethargy 80.39 10.60 263 117003 51178 56123623
Propofol infusion syndrome 80.08 10.60 38 117228 817 56173984
Confusional state 79.58 10.60 721 116545 207434 55967367
Motor developmental delay 79.58 10.60 24 117242 132 56174669
Blood prolactin increased 78.91 10.60 61 117205 3248 56171553
Anaemia 78.16 10.60 290 116976 267221 55907580
Impulsive behaviour 77.97 10.60 45 117221 1462 56173339
Strabismus 77.64 10.60 49 117217 1877 56172924
Injection site erythema 77.64 10.60 32 117234 77416 56097385
Mental impairment 77.40 10.60 113 117153 12609 56162192
Neurodevelopmental disorder 75.69 10.60 16 117250 9 56174792
Arnold-Chiari malformation 74.53 10.60 33 117233 601 56174200
Gingival hypertrophy 74.50 10.60 43 117223 1397 56173404
Infantile spasms 73.68 10.60 26 117240 250 56174551
Cardiac failure congestive 73.36 10.60 46 117220 87674 56087127
Gastrointestinal disorder 73.16 10.60 76 117190 112626 56062175
Ear malformation 72.78 10.60 24 117242 184 56174617
Pleurothotonus 72.51 10.60 41 117225 1280 56173521
Chest pain 72.37 10.60 182 117084 189615 55985186
Microcephaly 71.81 10.60 35 117231 800 56174001
Product dose omission issue 71.55 10.60 205 117061 204548 55970253
Abortion induced 71.15 10.60 94 117172 9551 56165250
Dystonia 70.80 10.60 107 117159 12314 56162487
Irritable bowel syndrome 70.73 10.60 27 117239 68431 56106370
Psoriasis 70.37 10.60 54 117212 92638 56082163
Knee arthroplasty 69.84 10.60 6 117260 44253 56130548
Hyperlactacidaemia 69 10.60 51 117215 2537 56172264
Atrial septal defect 68.60 10.60 76 117190 6430 56168371
Affect lability 67.59 10.60 94 117172 10031 56164770
Hepatic function abnormal 67.42 10.60 191 117075 34367 56140434
Toxic encephalopathy 67.21 10.60 72 117194 5866 56168935
Hepatic enzyme increased 67.17 10.60 162 117104 171222 56003579
Spina bifida 66.89 10.60 33 117233 775 56174026
Mitochondrial DNA mutation 66.81 10.60 26 117240 336 56174465
Lower respiratory tract infection 66.32 10.60 85 117181 114709 56060092
Stillbirth 66.23 10.60 73 117193 6141 56168660
Enuresis 64.70 10.60 47 117219 2276 56172525
Congenital eyelid malformation 64.60 10.60 13 117253 3 56174798
Oculogyric crisis 64.53 10.60 40 117226 1484 56173317
Ileus paralytic 64.34 10.60 60 117206 4135 56170666
Attention deficit hyperactivity disorder 63.45 10.60 49 117217 2605 56172196
Paranoia 63.30 10.60 94 117172 10650 56164151
Metabolic encephalopathy 63.27 10.60 66 117200 5214 56169587
COVID-19 63.26 10.60 39 117227 75019 56099782
Dyspraxia 63.25 10.60 23 117243 243 56174558
Antipsychotic drug level decreased 63.12 10.60 24 117242 290 56174511
Restlessness 63.06 10.60 158 117108 26428 56148373
Seizure cluster 62.30 10.60 22 117244 212 56174589
Anger 61.55 10.60 97 117169 11575 56163226
Brain oedema 61.46 10.60 104 117162 13167 56161634
Resting tremor 61.14 10.60 30 117236 696 56174105
Malignant neoplasm progression 60.97 10.60 39 117227 73548 56101253
Acidosis hyperchloraemic 60.52 10.60 24 117242 327 56174474
Communication disorder 60.37 10.60 45 117221 2268 56172533
Poisoning 60.12 10.60 101 117165 12712 56162089
Dementia 59.90 10.60 119 117147 17039 56157762
Hallucinations, mixed 59.77 10.60 59 117207 4365 56170436
Blood pressure increased 59.47 10.60 134 117132 145042 56029759
Death 59.30 10.60 442 116824 340984 55833817
Hypoaesthesia 59.27 10.60 129 117137 141362 56033439
Drug level below therapeutic 59.16 10.60 58 117208 4255 56170546
Weight increased 58.82 10.60 734 116532 228969 55945832
Neovascularisation 58.78 10.60 33 117233 1016 56173785
Influenza 57.69 10.60 68 117198 95193 56079608
Grandiosity 57.19 10.60 22 117244 275 56174526
Encephalitis autoimmune 57.14 10.60 36 117230 1375 56173426
Mental status changes 57.04 10.60 190 117076 37311 56137490
Inflammation 56.69 10.60 37 117229 69034 56105767
Suicidal behaviour 56.17 10.60 44 117222 2389 56172412
Hypertonia 56.08 10.60 55 117211 4037 56170764
Musculoskeletal pain 55.81 10.60 52 117214 81100 56093701
Dyspnoea exertional 55.78 10.60 22 117244 54667 56120134
C-reactive protein abnormal 55.41 10.60 6 117260 36803 56137998
Nasal congestion 55.36 10.60 24 117242 56346 56118455
Wheezing 55.32 10.60 45 117221 74981 56099820
Astigmatism 54.96 10.60 31 117235 963 56173838
Hepatic failure 54.85 10.60 174 117092 33312 56141489
Metabolic acidosis 54.61 10.60 197 117069 40257 56134544
Hallucination 53.82 10.60 224 117042 48925 56125876
Productive cough 53.57 10.60 25 117241 56207 56118594
Rhinorrhoea 53.35 10.60 26 117240 57011 56117790
Tonic clonic movements 52.93 10.60 33 117233 1237 56173564
Atrial fibrillation 52.81 10.60 91 117175 108806 56065995
Personal relationship issue 52.42 10.60 14 117252 45 56174756
Hypokinesia 52.37 10.60 95 117171 12708 56162093
Intra-abdominal pressure increased 52.31 10.60 19 117247 200 56174601
Differential white blood cell count abnormal 52.12 10.60 27 117239 705 56174096
Drug hypersensitivity 51.29 10.60 349 116917 274856 55899945
Contusion 50.62 10.60 121 117145 128309 56046492
Hypertension 50.54 10.60 300 116966 243978 55930823
Flushing 50.50 10.60 43 117223 70057 56104744
Cerebellar atrophy 50.43 10.60 26 117240 672 56174129
Injection site reaction 50.22 10.60 24 117242 53223 56121578
Blister 50.10 10.60 94 117172 108793 56066008
Fluid retention 50.05 10.60 25 117241 54053 56120748
Thrombosis 49.91 10.60 31 117235 59396 56115405
Dyslexia 49.81 10.60 20 117246 282 56174519
Injection site pruritus 49.61 10.60 13 117253 41918 56132883
Gastrointestinal haemorrhage 49.53 10.60 51 117215 75900 56098901
Hyponatraemia 49.27 10.60 373 116893 101766 56073035
Myalgia 49.22 10.60 128 117138 131897 56042904
Dysgraphia 49.14 10.60 43 117223 2727 56172074
Arachnodactyly 48.92 10.60 15 117251 88 56174713
Myopia 48.73 10.60 34 117232 1544 56173257
Bone pain 48.29 10.60 22 117244 50163 56124638
Affective disorder 48.28 10.60 59 117207 5544 56169257
Lip disorder 48.21 10.60 31 117235 1227 56173574
General physical health deterioration 47.85 10.60 187 117079 169823 56004978
Hip arthroplasty 47.59 10.60 11 117255 38612 56136189
Lordosis 47.51 10.60 19 117247 265 56174536
Selective eating disorder 47.38 10.60 36 117230 1868 56172933
Injection site swelling 47.03 10.60 16 117250 43562 56131239
Treatment failure 46.96 10.60 189 117077 170203 56004598
Hyperthermia 46.69 10.60 71 117195 8214 56166587
Clinodactyly 46.67 10.60 15 117251 105 56174696
Angiofibroma 46.55 10.60 15 117251 106 56174695
Ventricular septal defect 46.52 10.60 50 117216 4088 56170713
Depressed mood 46.50 10.60 174 117092 36185 56138616
Congenital scoliosis 46.47 10.60 10 117256 7 56174794
Neutropenia 46.46 10.60 519 116747 157648 56017153
Amenorrhoea 46.45 10.60 74 117192 8912 56165889
Retinogram abnormal 46.37 10.60 16 117250 143 56174658
Drop attacks 45.64 10.60 24 117242 647 56174154
Abdominal pain 44.91 10.60 335 116931 258470 55916331
Bronchitis 44.91 10.60 105 117161 112206 56062595
Disease progression 44.78 10.60 95 117171 105078 56069723
White blood cell count increased 44.40 10.60 198 117068 44561 56130240
Blood pressure systolic increased 44.06 10.60 15 117251 40821 56133980
Fibromyalgia 43.63 10.60 36 117230 59567 56115234
Mood swings 43.42 10.60 103 117163 16644 56158157
Multiple congenital abnormalities 43.34 10.60 22 117244 550 56174251
Chest discomfort 43.18 10.60 88 117178 98769 56076032
Blood lactic acid increased 43.04 10.60 58 117208 6006 56168795
Acute hepatic failure 43.02 10.60 102 117164 16476 56158325
Pneumatosis 42.97 10.60 20 117246 411 56174390
Logorrhoea 42.71 10.60 37 117229 2315 56172486
Aphasia 42.66 10.60 150 117116 30265 56144536
Reflexes abnormal 42.59 10.60 22 117244 571 56174230
Refusal of treatment by patient 42.50 10.60 53 117213 5085 56169716
Asterixis 42.13 10.60 28 117238 1173 56173628
Tooth malformation 42.00 10.60 9 117257 6 56174795
Oral mucosa erosion 41.89 10.60 27 117239 1073 56173728
Dry skin 41.79 10.60 23 117243 47086 56127715
Limbic encephalitis 41.69 10.60 17 117249 250 56174551
Antipsychotic drug level above therapeutic 41.69 10.60 26 117240 975 56173826
Inappropriate antidiuretic hormone secretion 41.67 10.60 90 117176 13666 56161135
Nephrogenic diabetes insipidus 41.64 10.60 25 117241 875 56173926
Medication overuse headache 41.57 10.60 23 117243 688 56174113
Pectus excavatum 41.47 10.60 13 117253 83 56174718
Craniosynostosis 41.21 10.60 15 117251 159 56174642
Hot flush 41.18 10.60 23 117243 46703 56128098
Change in seizure presentation 41.15 10.60 17 117249 259 56174542
Interstitial lung disease 41.11 10.60 35 117231 57028 56117773
Dysmetria 41.08 10.60 20 117246 456 56174345
Coordination abnormal 41.05 10.60 85 117181 12536 56162265
Malaise 40.77 10.60 531 116735 367329 55807472
Oropharyngeal pain 40.63 10.60 70 117196 83718 56091083
Chills 40.16 10.60 97 117169 102507 56072294
Injection site bruising 40.11 10.60 15 117251 38506 56136295
Camptodactyly congenital 39.88 10.60 9 117257 10 56174791
Urinary incontinence 39.87 10.60 144 117122 29441 56145360
Night sweats 39.75 10.60 18 117248 41195 56133606
Eosinophilic pleural effusion 39.73 10.60 11 117255 42 56174759
Gene mutation 39.64 10.60 29 117237 1420 56173381
Psychotic behaviour 39.57 10.60 21 117245 577 56174224
Hallucination, visual 39.54 10.60 102 117164 17366 56157435
Plagiocephaly 39.52 10.60 11 117255 43 56174758
Tachycardia 39.51 10.60 365 116901 105511 56069290
Pain in jaw 39.38 10.60 17 117249 40019 56134782
Carnitine decreased 38.87 10.60 8 117258 3 56174798
Delusion of grandeur 38.75 10.60 14 117252 145 56174656
Cataract 38.70 10.60 30 117236 51217 56123584
Adjustment disorder with mixed anxiety and depressed mood 38.63 10.60 12 117254 74 56174727
Necrosis ischaemic 38.54 10.60 23 117243 796 56174005
Bradykinesia 38.45 10.60 49 117217 4805 56169996
Sluggishness 38.37 10.60 48 117218 4620 56170181
Ill-defined disorder 38.30 10.60 52 117214 68491 56106310
Hypersexuality 38.06 10.60 19 117247 458 56174343
Partial seizures with secondary generalisation 38.02 10.60 18 117248 385 56174416
Mydriasis 37.71 10.60 76 117190 10995 56163806
Neutrophil count increased 37.67 10.60 91 117175 14874 56159927
Asthenia 37.65 10.60 496 116770 342477 55832324
Psychiatric decompensation 37.10 10.60 27 117239 1311 56173490
Sinus rhythm 37.01 10.60 21 117245 660 56174141
Congenital anomaly 36.96 10.60 29 117237 1578 56173223
Metabolic disorder 36.90 10.60 51 117215 5410 56169391
Muscle spasms 36.82 10.60 154 117112 137217 56037584
Depressive symptom 36.71 10.60 41 117225 3500 56171301
Unresponsive to stimuli 36.63 10.60 147 117119 31578 56143223
Psychotic symptom 36.55 10.60 27 117239 1342 56173459
Apathy 36.39 10.60 62 117204 7892 56166909
Glycosuria 36.39 10.60 25 117241 1107 56173694
Weight gain poor 36.33 10.60 22 117244 782 56174019
Epistaxis 36.29 10.60 52 117214 66971 56107830
Hypermetropia 35.90 10.60 18 117248 438 56174363
Oropharyngeal oedema 35.76 10.60 16 117250 299 56174502
Asthma 35.73 10.60 118 117148 112652 56062149
Hyperchloraemia 35.47 10.60 21 117245 716 56174085
Congenital joint malformation 35.40 10.60 8 117258 9 56174792
Throat irritation 35.27 10.60 12 117254 32671 56142130
Galactorrhoea 35.17 10.60 42 117224 3853 56170948
Product use issue 35.09 10.60 235 117031 185806 55988995
Haematochezia 35.09 10.60 24 117242 43694 56131107
Bradycardia neonatal 35.04 10.60 22 117244 835 56173966
Pneumonia 35.03 10.60 617 116649 406481 55768320
Platelet count decreased 34.91 10.60 357 116909 106026 56068775
Posture abnormal 34.80 10.60 32 117234 2166 56172635
Cleft palate 34.64 10.60 23 117243 962 56173839
Balance disorder 34.43 10.60 275 116991 76245 56098556
Accidental overdose 34.13 10.60 107 117159 20354 56154447
Pancreatitis necrotising 34.07 10.60 26 117240 1358 56173443
Gait disturbance 34.00 10.60 503 116763 162818 56011983
Mobility decreased 33.89 10.60 100 117166 98891 56075910
Pulmonary fibrosis 33.76 10.60 10 117256 29748 56145053
Hyperglycinaemia 33.74 10.60 7 117259 3 56174798
Speech sound disorder 33.74 10.60 7 117259 3 56174798
Antipsychotic drug level below therapeutic 33.64 10.60 15 117251 278 56174523
Poor sucking reflex 33.55 10.60 14 117252 219 56174582
Leukocytosis 33.08 10.60 117 117149 23674 56151127
Blood gases abnormal 33.08 10.60 20 117246 709 56174092
Congenital hair disorder 33.01 10.60 10 117256 56 56174745
Foetal death 32.96 10.60 62 117204 8525 56166276
High arched palate 32.84 10.60 11 117255 89 56174712
Screaming 32.76 10.60 36 117230 3018 56171783
Polydipsia 32.75 10.60 37 117229 3198 56171603
Nipple disorder 32.73 10.60 11 117255 90 56174711
Conjunctival hyperaemia 32.66 10.60 31 117235 2185 56172616
Rash maculo-papular 32.63 10.60 133 117133 28774 56146027
Diverticulitis 32.54 10.60 17 117249 35835 56138966
Fungal infection 32.47 10.60 14 117252 32979 56141822
Neoplasm progression 32.45 10.60 13 117253 32003 56142798
Brief psychotic disorder, with postpartum onset 32.37 10.60 9 117257 35 56174766
Gaze palsy 32.35 10.60 25 117241 1330 56173471
Poisoning deliberate 32.33 10.60 67 117199 9886 56164915
Reading disorder 32.26 10.60 20 117246 742 56174059
Rabbit syndrome 32.19 10.60 15 117251 309 56174492
Neck pain 32.12 10.60 49 117217 61506 56113295
Cystitis 31.89 10.60 33 117233 49005 56125796
Joint stiffness 31.85 10.60 17 117249 35408 56139393
Anticonvulsant drug level abnormal 31.79 10.60 9 117257 38 56174763
Anaphylactic reaction 31.72 10.60 46 117220 58949 56115852
Diplopia 31.68 10.60 104 117162 20265 56154536
Tic 31.55 10.60 24 117242 1247 56173554
Localised infection 31.49 10.60 9 117257 27403 56147398
Device expulsion 31.46 10.60 12 117254 30437 56144364
Drug level above therapeutic 31.39 10.60 42 117224 4320 56170481
Skin ulcer 31.24 10.60 21 117245 38587 56136214
Breast hyperplasia 31.08 10.60 14 117252 266 56174535
Congenital flat feet 31.06 10.60 6 117260 0 56174801
Red blood cell sedimentation rate increased 30.89 10.60 19 117247 36604 56138197
Depression 30.84 10.60 537 116729 179580 55995221
Respiratory acidosis 30.82 10.60 50 117216 6113 56168688
Renal tubular acidosis 30.82 10.60 26 117240 1569 56173232
Angiomyolipoma 30.78 10.60 13 117253 210 56174591
Respiratory disorder neonatal 30.70 10.60 21 117245 923 56173878
Hypophosphataemic osteomalacia 30.49 10.60 12 117254 160 56174641
Drooling 30.44 10.60 37 117229 3457 56171344
Epileptic encephalopathy 30.38 10.60 14 117252 281 56174520
Pancreatitis acute 30.29 10.60 118 117148 25006 56149795
Mood altered 30.24 10.60 78 117188 13277 56161524
Loss of personal independence in daily activities 30.23 10.60 79 117187 81290 56093511
Bursitis 29.98 10.60 10 117256 27572 56147229
Pulmonary arterial hypertension 29.89 10.60 9 117257 26494 56148307
Ovarian granulosa-theca cell tumour 29.89 10.60 8 117258 26 56174775
Hirsutism 29.79 10.60 22 117244 1093 56173708
Cerebral ventricle dilatation 29.74 10.60 21 117245 972 56173829
Polydactyly 29.67 10.60 14 117252 297 56174504
Deafness congenital 29.64 10.60 7 117259 11 56174790
Akinesia 29.60 10.60 25 117241 1511 56173290
Withdrawal syndrome 29.38 10.60 95 117171 18367 56156434
Prognathism 29.32 10.60 10 117256 86 56174715
Strabismus congenital 29.18 10.60 9 117257 54 56174747
Hypermobility syndrome 29.06 10.60 19 117247 774 56174027
Congenital oral malformation 29.04 10.60 12 117254 183 56174618
Automatism 28.77 10.60 9 117257 57 56174744
Congenital central nervous system anomaly 28.76 10.60 14 117252 319 56174482
Obsessive-compulsive disorder 28.71 10.60 37 117229 3669 56171132
Macular degeneration 28.67 10.60 3 117263 18905 56155896
Subileus 28.67 10.60 33 117233 2911 56171890
Verbal abuse 28.63 10.60 10 117256 93 56174708
Hereditary ataxia 28.60 10.60 8 117258 32 56174769
Ketosis-prone diabetes mellitus 28.57 10.60 7 117259 14 56174787
Dyscalculia 28.44 10.60 10 117256 95 56174706
Growth retardation 28.43 10.60 22 117244 1173 56173628
Brain death 28.32 10.60 33 117233 2950 56171851
Palpitations 27.79 10.60 110 117156 99562 56075239
Paraesthesia 27.64 10.60 159 117107 130355 56044446
Mucosal inflammation 27.62 10.60 29 117237 42781 56132020
Obesity 27.52 10.60 106 117160 22342 56152459
Metastases to bone 27.37 10.60 4 117262 19504 56155297
Pancreatitis 27.25 10.60 174 117092 44906 56129895
Cogwheel rigidity 27.17 10.60 26 117240 1851 56172950
Ear disorder 27.11 10.60 35 117231 3476 56171325
Impaired reasoning 27.07 10.60 9 117257 71 56174730
Shock 26.97 10.60 103 117163 21625 56153176
Eye movement disorder 26.93 10.60 41 117225 4748 56170053
Sexually inappropriate behaviour 26.90 10.60 10 117256 113 56174688
Conductive deafness 26.74 10.60 9 117257 74 56174727
Hepatotoxicity 26.64 10.60 132 117134 31021 56143780
Cardiac failure 26.62 10.60 85 117181 82008 56092793
Physical assault 26.58 10.60 19 117247 897 56173904
Motor dysfunction 26.53 10.60 60 117206 9397 56165404
Heart rate decreased 26.52 10.60 27 117239 40400 56134401
Echolalia 26.37 10.60 11 117255 172 56174629
Negativism 26.24 10.60 14 117252 389 56174412
Myocardial infarction 26.21 10.60 102 117164 92768 56082033
Social avoidant behaviour 26.16 10.60 31 117235 2821 56171980
Heterophoria 26.09 10.60 7 117259 23 56174778
Disinhibition 26.08 10.60 18 117248 803 56173998
Staring 26.06 10.60 23 117243 1475 56173326
Weight decreased 26.06 10.60 349 116917 240365 55934436
Cerebellar syndrome 25.90 10.60 34 117232 3433 56171368
Stereotypy 25.63 10.60 14 117252 408 56174393
Ultrasound ovary abnormal 25.46 10.60 9 117257 87 56174714
Lactate pyruvate ratio increased 25.46 10.60 9 117257 87 56174714
Breast cancer 25.35 10.60 39 117227 48794 56126007
Nasal disorder 25.24 10.60 29 117237 2553 56172248
Apraxia 25.24 10.60 24 117242 1695 56173106
Illness 25.06 10.60 21 117245 34490 56140311
Monocytosis 24.94 10.60 13 117253 344 56174457
Illogical thinking 24.77 10.60 8 117258 57 56174744
Osteoporosis 24.77 10.60 44 117222 52008 56122793
Pulmonary hypertension 24.74 10.60 23 117243 35921 56138880
Drug withdrawal syndrome 24.60 10.60 113 117153 25744 56149057
Joint range of motion decreased 24.58 10.60 11 117255 25354 56149447
Pneumonitis 24.44 10.60 18 117248 31546 56143255
Upper respiratory tract infection 24.41 10.60 72 117194 71216 56103585
Lennox-Gastaut syndrome 24.39 10.60 12 117254 280 56174521
Hepatic cirrhosis 24.39 10.60 7 117259 21256 56153545
Basal cell carcinoma 24.35 10.60 11 117255 25210 56149591
Porphyria acute 24.34 10.60 18 117248 896 56173905
Conversion disorder 24.30 10.60 23 117243 1615 56173186
Precocious puberty 24.28 10.60 11 117255 212 56174589
Congenital cystic kidney disease 24.24 10.60 13 117253 365 56174436
Intentional product misuse 24.21 10.60 187 117079 51317 56123484
Dacryostenosis congenital 24.17 10.60 6 117260 13 56174788
Drug eruption 24.08 10.60 112 117154 25651 56149150
Hypothyroidism 24.06 10.60 149 117117 38047 56136754
Palmar-plantar erythrodysaesthesia syndrome 24.04 10.60 7 117259 21058 56153743
Eosinophilia 23.96 10.60 94 117172 19983 56154818
Vestibular migraine 23.95 10.60 11 117255 219 56174582
Mitochondrial cytopathy 23.72 10.60 11 117255 224 56174577
Lymphangioleiomyomatosis 23.59 10.60 10 117256 163 56174638
Choreoathetosis 23.55 10.60 14 117252 481 56174320
Rotavirus infection 23.53 10.60 12 117254 303 56174498
Metabolic syndrome 23.47 10.60 21 117245 1372 56173429
Bipolar II disorder 23.42 10.60 12 117254 306 56174495
Osteonecrosis of jaw 23.37 10.60 21 117245 33337 56141464
Miosis 23.35 10.60 46 117220 6546 56168255
Hypervolaemia 23.35 10.60 13 117253 26445 56148356
Cellulitis 23.34 10.60 79 117187 74870 56099931
Erythema 23.29 10.60 210 117056 155729 56019072
Borderline personality disorder 23.20 10.60 16 117250 713 56174088
Blood pressure fluctuation 23.17 10.60 30 117236 40330 56134471
Memory impairment 23.14 10.60 279 116987 86278 56088523
Hypotonia neonatal 23.12 10.60 19 117247 1105 56173696
Agranulocytosis 23.04 10.60 101 117165 22558 56152243
Feeling hot 23.04 10.60 32 117234 41755 56133046
Ulcer 23.00 10.60 9 117257 22476 56152325
Mutism 22.96 10.60 21 117245 1412 56173389
Neoplasm malignant 22.87 10.60 14 117252 27041 56147760
Executive dysfunction 22.74 10.60 10 117256 179 56174622
Injection site rash 22.62 10.60 4 117262 16954 56157847
Sinus congestion 22.59 10.60 3 117263 15721 56159080
Polycystic ovaries 22.47 10.60 31 117235 3283 56171518
Magnetic resonance imaging head abnormal 22.19 10.60 23 117243 1803 56172998
Influenza B virus test positive 22.19 10.60 11 117255 261 56174540
Right ventricular hypertrophy 22.14 10.60 15 117251 649 56174152
Surgery 22.11 10.60 21 117245 32465 56142336
Illiteracy 22.08 10.60 6 117260 21 56174780
Macroglossia 21.76 10.60 15 117251 668 56174133
Schizoaffective disorder bipolar type 21.67 10.60 9 117257 139 56174662
Right ventricular failure 21.55 10.60 4 117262 16375 56158426
Knee deformity 21.54 10.60 18 117248 1072 56173729
Drug screen false positive 21.50 10.60 16 117250 804 56173997
Metastases to liver 21.49 10.60 9 117257 21577 56153224
Urinary tract infection 21.46 10.60 362 116904 240151 55934650
Thinking abnormal 21.43 10.60 57 117209 9884 56164917
Urine amphetamine positive 21.42 10.60 7 117259 52 56174749
Therapeutic product effective for unapproved indication 21.39 10.60 8 117258 92 56174709
Neglect of personal appearance 21.32 10.60 8 117258 93 56174708
Euphoric mood 21.31 10.60 35 117231 4323 56170478
Developmental regression 21.26 10.60 6 117260 25 56174776
Cleft uvula 21.12 10.60 5 117261 8 56174793
Dysgeusia 20.93 10.60 33 117233 40882 56133919
Increased appetite 20.80 10.60 52 117214 8683 56166118
Retinitis pigmentosa 20.80 10.60 8 117258 100 56174701
Optic nerve hypoplasia 20.70 10.60 4 117262 0 56174801
Anomaly of orbit, congenital 20.70 10.60 4 117262 0 56174801
Intelligence test abnormal 20.70 10.60 4 117262 0 56174801
Clonus 20.61 10.60 34 117232 4215 56170586
Full blood count abnormal 20.61 10.60 15 117251 26447 56148354
Creatinine renal clearance decreased 20.39 10.60 3 117263 14556 56160245
Mitochondrial enzyme deficiency 20.37 10.60 6 117260 30 56174771
Cross sensitivity reaction 20.23 10.60 23 117243 2002 56172799
Acquired macroglossia 20.17 10.60 9 117257 167 56174634
Food interaction 20.10 10.60 15 117251 757 56174044
Kidney infection 20.07 10.60 9 117257 20716 56154085
Cardiac steatosis 19.89 10.60 6 117260 33 56174768
Ligament laxity 19.88 10.60 9 117257 173 56174628
Hiatus hernia 19.88 10.60 8 117258 19644 56155157
Acute generalised exanthematous pustulosis 19.69 10.60 55 117211 9814 56164987
Constipation 19.66 10.60 299 116967 201644 55973157
Perseveration 19.59 10.60 10 117256 253 56174548
Anaemia macrocytic 19.51 10.60 28 117238 3075 56171726
Injection site haemorrhage 19.46 10.60 11 117255 22190 56152611
Chorea 19.39 10.60 19 117247 1393 56173408
Attention-seeking behaviour 19.33 10.60 7 117259 73 56174728
Flatulence 19.29 10.60 22 117244 31266 56143535
Transient aphasia 19.18 10.60 6 117260 38 56174763
Oral herpes 19.13 10.60 12 117254 22878 56151923
Hypoplastic left heart syndrome 19.12 10.60 9 117257 190 56174611
Troponin increased 19.11 10.60 50 117216 8585 56166216
Thermal burn 19.09 10.60 38 117228 5447 56169354
Hypersomnia 19.09 10.60 76 117190 16265 56158536
Tachyphrenia 18.99 10.60 18 117248 1266 56173535
Congenital hepatomegaly 18.98 10.60 5 117261 15 56174786
Reduced facial expression 18.97 10.60 21 117245 1775 56173026
Fanconi syndrome acquired 18.91 10.60 16 117250 969 56173832
Inappropriate affect 18.84 10.60 15 117251 834 56173967
Bradypnoea 18.83 10.60 28 117238 3175 56171626
Colitis ulcerative 18.77 10.60 14 117252 24377 56150424
Lipids 18.74 10.60 5 117261 16 56174785
Congenital hearing disorder 18.74 10.60 5 117261 16 56174785
Blood insulin increased 18.73 10.60 8 117258 133 56174668
Product use in unapproved indication 18.70 10.60 404 116862 140418 56034383
Aspiration 18.59 10.60 53 117213 9568 56165233
Nephrocalcinosis 18.50 10.60 16 117250 999 56173802
Full blood count decreased 18.49 10.60 13 117253 23336 56151465
Microstomia 18.47 10.60 4 117262 3 56174798
Tooth infection 18.41 10.60 5 117261 15747 56159054
Limb discomfort 18.36 10.60 17 117249 26605 56148196
Pneumocystis jirovecii pneumonia 18.32 10.60 5 117261 15696 56159105
Lip erosion 18.16 10.60 15 117251 879 56173922
Pulmonary mass 18.14 10.60 10 117256 20460 56154341
Dysphagia 18.07 10.60 255 117011 81692 56093109
Rectal haemorrhage 18.02 10.60 37 117229 41430 56133371
Oral pain 17.89 10.60 17 117249 26276 56148525
Urine sodium increased 17.88 10.60 7 117259 92 56174709
Lipid metabolism disorder 17.86 10.60 6 117260 49 56174752
Gastrooesophageal reflux disease 17.85 10.60 101 117165 83156 56091645
Sinus tachycardia 17.72 10.60 93 117173 22351 56152450
Hip fracture 17.71 10.60 18 117248 26955 56147846
Thyroxine free decreased 17.69 10.60 13 117253 641 56174160
Brachydactyly 17.68 10.60 7 117259 95 56174706
Microphthalmos 17.66 10.60 8 117258 154 56174647
Ascites 17.62 10.60 32 117234 37512 56137289
Blood triglycerides increased 17.61 10.60 59 117207 11618 56163183
Musculoskeletal discomfort 17.59 10.60 6 117260 16312 56158489
Prominent epicanthal folds 17.55 10.60 6 117260 52 56174749
Heart disease congenital 17.52 10.60 17 117249 1231 56173570
Bladder sphincter atony 17.52 10.60 8 117258 157 56174644
Osmolar gap increased 17.49 10.60 5 117261 22 56174779
Sciatica 17.48 10.60 17 117249 25993 56148808
Monocyte count decreased 17.48 10.60 21 117245 1939 56172862
Head titubation 17.45 10.60 14 117252 787 56174014
Hyperphagia 17.44 10.60 19 117247 1577 56173224
Cerebrovascular accident 17.42 10.60 128 117138 99142 56075659
Opisthotonus 17.41 10.60 10 117256 322 56174479
Dysphoria 17.40 10.60 34 117232 4808 56169993
Tendonitis 17.30 10.60 8 117258 18089 56156712
Rash morbilliform 17.27 10.60 26 117240 2981 56171820
Benign congenital hypotonia 17.16 10.60 6 117260 56 56174745
False positive investigation result 17.10 10.60 12 117254 550 56174251
School refusal 17.05 10.60 4 117262 6 56174795
Spina bifida occulta 17.05 10.60 4 117262 6 56174795
Clonic convulsion 17.03 10.60 13 117253 679 56174122
Exostosis 16.99 10.60 5 117261 14938 56159863
VIth nerve paralysis 16.97 10.60 14 117252 819 56173982
Parkinsonian gait 16.96 10.60 11 117255 442 56174359
Therapy interrupted 16.94 10.60 17 117249 25608 56149193
Joint effusion 16.91 10.60 5 117261 14893 56159908
Clostridium difficile infection 16.91 10.60 19 117247 27179 56147622
Erythema multiforme 16.90 10.60 51 117215 9503 56165298
Acidosis 16.68 10.60 54 117212 10447 56164354
Anotia 16.67 10.60 4 117262 7 56174794
Eye pain 16.63 10.60 24 117242 30823 56143978
Urine calcium/creatinine ratio increased 16.58 10.60 7 117259 113 56174688
Renal hypoplasia 16.50 10.60 5 117261 28 56174773
Bacteraemia 16.42 10.60 6 117260 15625 56159176
CSF oligoclonal band present 16.39 10.60 9 117257 265 56174536
Micrognathia 16.39 10.60 9 117257 265 56174536
Device issue 16.39 10.60 12 117254 21094 56153707
Transfusion 16.36 10.60 4 117262 13516 56161285
Pancreatic injury 16.36 10.60 5 117261 29 56174772
Vomiting 16.34 10.60 860 116406 497368 55677433
Sneezing 16.30 10.60 6 117260 15554 56159247
Scoliosis 16.23 10.60 41 117225 6892 56167909
Intestinal ischaemia 16.14 10.60 41 117225 6914 56167887
Megakaryocytes abnormal 16.07 10.60 5 117261 31 56174770
Hospitalisation 16.07 10.60 91 117175 74909 56099892
Glaucoma 16.05 10.60 8 117258 17321 56157480
Haemoptysis 16.03 10.60 19 117247 26541 56148260
Electrocardiogram J wave abnormal 16.01 10.60 4 117262 9 56174792
Head circumference abnormal 16.01 10.60 4 117262 9 56174792
Generalised anxiety disorder 15.99 10.60 20 117246 1924 56172877
Lipids abnormal 15.97 10.60 9 117257 279 56174522
Incontinence 15.97 10.60 54 117212 10681 56164120
Saccadic eye movement 15.97 10.60 6 117260 70 56174731
Self-injurious ideation 15.96 10.60 22 117244 2328 56172473
Procedural pain 15.86 10.60 7 117259 16264 56158537
Emotional disorder 15.85 10.60 59 117207 12236 56162565
Laryngeal stenosis 15.85 10.60 14 117252 899 56173902
Sinus disorder 15.83 10.60 12 117254 20722 56154079
Vascular encephalopathy 15.82 10.60 10 117256 384 56174417
Prothrombin time shortened 15.81 10.60 19 117247 1754 56173047
Plasmodium falciparum infection 15.81 10.60 5 117261 33 56174768
Autonomic nervous system imbalance 15.73 10.60 23 117243 2570 56172231
Sinus bradycardia 15.72 10.60 63 117203 13523 56161278
Immunodeficiency 15.67 10.60 7 117259 16150 56158651
Otitis media 15.62 10.60 32 117234 4684 56170117
Drug level fluctuating 15.55 10.60 10 117256 396 56174405
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.53 10.60 3 117263 0 56174801
Congenital cutis laxa 15.53 10.60 3 117263 0 56174801
Congenital myopia 15.53 10.60 3 117263 0 56174801
Social (pragmatic) communication disorder 15.53 10.60 3 117263 0 56174801
Carnitine palmitoyltransferase deficiency 15.53 10.60 3 117263 0 56174801
Tibial torsion 15.53 10.60 3 117263 0 56174801
Rhinotracheitis 15.53 10.60 3 117263 0 56174801
Alpers disease 15.53 10.60 3 117263 0 56174801
Diabetic encephalopathy 15.53 10.60 3 117263 0 56174801
Cryptorchism 15.53 10.60 3 117263 0 56174801
Blood 1,25-dihydroxycholecalciferol decreased 15.53 10.60 3 117263 0 56174801
Cognitive linguistic deficit 15.53 10.60 3 117263 0 56174801
Premature baby 15.45 10.60 80 117186 19125 56155676
Asphyxia 15.43 10.60 36 117230 5753 56169048
Systemic inflammatory response syndrome 15.38 10.60 34 117232 5244 56169557
Serositis 15.37 10.60 12 117254 648 56174153
Incoherent 15.37 10.60 30 117236 4239 56170562
Dysphonia 15.37 10.60 41 117225 41906 56132895
Lung disorder 15.33 10.60 57 117209 52540 56122261
Acute kidney injury 15.33 10.60 383 116883 240380 55934421
Developmental coordination disorder 15.32 10.60 5 117261 37 56174764
Status migrainosus 15.30 10.60 7 117259 138 56174663
Hepatomegaly 15.29 10.60 55 117211 11220 56163581
Drug level changed 15.23 10.60 8 117258 215 56174586
Electrocardiogram T wave inversion 15.22 10.60 26 117240 3317 56171484
Epileptic psychosis 15.20 10.60 5 117261 38 56174763
Rib fracture 15.19 10.60 12 117254 20297 56154504
Blood urea decreased 15.15 10.60 21 117245 2233 56172568
Device related infection 15.06 10.60 14 117252 21866 56152935
Mental disability 15.05 10.60 6 117260 83 56174718
Mucosal erosion 15.02 10.60 16 117250 1295 56173506
Drug monitoring procedure incorrectly performed 14.99 10.60 7 117259 145 56174656
Poor personal hygiene 14.94 10.60 9 117257 317 56174484
Pulmonary valve stenosis congenital 14.90 10.60 7 117259 147 56174654
Fine motor delay 14.86 10.60 7 117259 148 56174653
Electrocardiogram QRS complex shortened 14.86 10.60 10 117256 428 56174373
Grunting 14.84 10.60 8 117258 227 56174574
Simple partial seizures 14.83 10.60 11 117255 550 56174251
Candida infection 14.82 10.60 19 117247 25648 56149153
Gamma-glutamyltransferase increased 14.81 10.60 113 117153 30892 56143909
Congenital eye disorder 14.72 10.60 4 117262 14 56174787
Coronary artery disease 14.68 10.60 26 117240 30770 56144031
Intestinal strangulation 14.61 10.60 6 117260 90 56174711
Adenoidal hypertrophy 14.56 10.60 5 117261 44 56174757
Hypoproteinaemia 14.55 10.60 19 117247 1909 56172892
Breast cancer metastatic 14.54 10.60 7 117259 15462 56159339
Diabetes mellitus 14.54 10.60 171 117095 52564 56122237
Cardiac disorder 14.53 10.60 48 117218 45839 56128962
Hepatic steatosis 14.52 10.60 99 117167 26115 56148686
Congenital nipple anomaly 14.50 10.60 4 117262 15 56174786
Aspartate aminotransferase decreased 14.47 10.60 12 117254 707 56174094
Pleocytosis 14.44 10.60 12 117254 709 56174092
Drug ineffective 14.41 10.60 2152 115114 916837 55257964
Transaminases increased 14.39 10.60 106 117160 28664 56146137
Hydrocephalus 14.38 10.60 32 117234 4957 56169844
Crying 14.37 10.60 85 117181 21355 56153446
Idiosyncratic drug reaction 14.37 10.60 12 117254 714 56174087
Grip strength decreased 14.32 10.60 8 117258 16248 56158553
Therapeutic response changed 14.26 10.60 13 117253 870 56173931
Faecal vomiting 14.22 10.60 11 117255 586 56174215
Tubo-ovarian abscess 14.18 10.60 9 117257 348 56174453
Dehydration 14.17 10.60 239 117027 158586 56016215
Thought blocking 14.14 10.60 6 117260 98 56174703
Oral candidiasis 14.14 10.60 11 117255 18752 56156049
Gliosis 14.11 10.60 8 117258 251 56174550
Wound infection 14.09 10.60 7 117259 15186 56159615
Faeces discoloured 14.08 10.60 9 117257 16987 56157814
Decreased activity 14.05 10.60 34 117232 5562 56169239
Acute myeloid leukaemia 14.04 10.60 9 117257 16963 56157838
Amniocentesis abnormal 13.98 10.60 6 117260 101 56174700
Quadriparesis 13.96 10.60 18 117248 1786 56173015
Diverticulum 13.94 10.60 3 117263 11063 56163738
Nodule 13.93 10.60 11 117255 18608 56156193
Ebstein's anomaly 13.92 10.60 4 117262 18 56174783
Renal failure 13.92 10.60 155 117111 110345 56064456
Hypoglycaemia neonatal 13.79 10.60 13 117253 908 56173893
Coma hepatic 13.78 10.60 11 117255 614 56174187
Intervertebral disc protrusion 13.65 10.60 15 117251 21679 56153122
Congenital laryngeal stridor 13.65 10.60 5 117261 54 56174747
Withdrawal catatonia 13.65 10.60 5 117261 54 56174747
Tachypnoea 13.63 10.60 66 117200 15364 56159437
Hyperkalaemia 13.63 10.60 57 117209 50808 56123993
Transferrin saturation decreased 13.62 10.60 11 117255 624 56174177
Maternal exposure during breast feeding 13.59 10.60 26 117240 3621 56171180
Gaucher's disease 13.58 10.60 4 117262 20 56174781
Tympanic membrane disorder 13.58 10.60 7 117259 181 56174620
Hypotension 13.57 10.60 645 116621 249863 55924938
Blood sodium increased 13.57 10.60 21 117245 2467 56172334
Accidental poisoning 13.50 10.60 11 117255 632 56174169
Childhood asthma 13.49 10.60 5 117261 56 56174745
Blood pyruvic acid increased 13.46 10.60 3 117263 3 56174798
Rash pruritic 13.44 10.60 60 117206 52534 56122267
Deja vu 13.33 10.60 5 117261 58 56174743
Coma acidotic 13.32 10.60 6 117260 114 56174687
Malignant melanoma 13.31 10.60 3 117263 10716 56164085
Postictal state 13.30 10.60 13 117253 950 56173851
Activated partial thromboplastin time abnormal 13.27 10.60 6 117260 115 56174686
Blood citric acid increased 13.26 10.60 5 117261 59 56174742
Cell death 13.25 10.60 20 117246 2299 56172502
Anuria 13.18 10.60 54 117212 11706 56163095
Cerebral palsy 13.18 10.60 6 117260 117 56174684
Drug dependence 13.02 10.60 86 117180 22447 56152354
Hyperacusis 13.02 10.60 18 117248 1910 56172891
Cerebral disorder 13.00 10.60 27 117239 3989 56170812
Cortical visual impairment 12.99 10.60 3 117263 4 56174797
Benign rolandic epilepsy 12.99 10.60 3 117263 4 56174797
Joint hyperextension 12.95 10.60 8 117258 295 56174506
Seasonal allergy 12.93 10.60 10 117256 17098 56157703
Febrile convulsion 12.91 10.60 9 117257 408 56174393
Multiple allergies 12.91 10.60 3 117263 10493 56164308
Haemorrhage 12.87 10.60 67 117199 56330 56118471
Maternal drugs affecting foetus 12.85 10.60 31 117235 5062 56169739
Hand-eye coordination impaired 12.83 10.60 4 117262 25 56174776
Anxiety 12.83 10.60 508 116758 192664 55982137
Extensor plantar response 12.81 10.60 14 117252 1166 56173635
Epileptic aura 12.75 10.60 5 117261 66 56174735
Pharyngeal disorder 12.72 10.60 17 117249 1746 56173055
Dyspepsia 12.63 10.60 112 117154 83359 56091442
Arrhythmia 12.60 10.60 120 117146 34963 56139838
Aura 12.60 10.60 13 117253 1014 56173787
Intervertebral disc degeneration 12.58 10.60 7 117259 14247 56160554
Therapeutic product ineffective for unapproved indication 12.57 10.60 7 117259 212 56174589
Injection site warmth 12.56 10.60 7 117259 14236 56160565
Laboratory test abnormal 12.55 10.60 20 117246 24675 56150126
Blood bicarbonate increased 12.54 10.60 11 117255 700 56174101
Cardiac murmur 12.50 10.60 52 117214 11349 56163452
Joint laxity 12.49 10.60 20 117246 2419 56172382
Copper deficiency 12.49 10.60 5 117261 70 56174731
High-pitched crying 12.44 10.60 4 117262 28 56174773
Blood alkaline phosphatase increased 12.43 10.60 130 117136 38815 56135986
Perforation 12.40 10.60 13 117253 1033 56173768
Suspected suicide attempt 12.40 10.60 6 117260 135 56174666
Gout 12.32 10.60 5 117261 12216 56162585
Liver function test increased 12.31 10.60 25 117241 28108 56146693
Dry eye 12.27 10.60 36 117230 35680 56139121
Skin discolouration 12.27 10.60 34 117232 34322 56140479
Heart rate irregular 12.26 10.60 15 117251 20664 56154137
Syndactyly 12.26 10.60 8 117258 325 56174476
Hypersomnia-bulimia syndrome 12.25 10.60 3 117263 6 56174795
Congenital inguinal hernia 12.25 10.60 3 117263 6 56174795
Enlarged foetal cisterna magna 12.25 10.60 3 117263 6 56174795
Congenital neurological disorder 12.25 10.60 3 117263 6 56174795
Central nervous system lesion 12.24 10.60 47 117219 9891 56164910
Hyperreflexia 12.24 10.60 31 117235 5219 56169582
Glassy eyes 12.23 10.60 5 117261 74 56174727
Bronchiolitis 12.23 10.60 20 117246 2462 56172339
Congenital hypothyroidism 12.22 10.60 7 117259 224 56174577
Hostility 12.22 10.60 17 117249 1814 56172987
Binocular eye movement disorder 12.21 10.60 4 117262 30 56174771
Eye swelling 12.16 10.60 16 117250 21360 56153441
Cardio-respiratory arrest 12.13 10.60 172 117094 55149 56119652
Uveitis 12.10 10.60 4 117262 11091 56163710
Nose deformity 12.08 10.60 6 117260 143 56174658
Gallbladder disorder 12.04 10.60 11 117255 17323 56157478
Encapsulating peritoneal sclerosis 12.02 10.60 8 117258 336 56174465
Body temperature decreased 11.98 10.60 12 117254 18096 56156705
Food refusal 11.98 10.60 8 117258 338 56174463
Muscle twitching 11.94 10.60 66 117200 16176 56158625
Respiratory tract congestion 11.93 10.60 9 117257 15582 56159219
Convulsive threshold lowered 11.91 10.60 8 117258 341 56174460
Disorganised speech 11.91 10.60 13 117253 1082 56173719
Musculoskeletal chest pain 11.90 10.60 14 117252 19627 56155174
Septic shock 11.88 10.60 76 117190 60759 56114042
Blood phosphorus increased 11.87 10.60 21 117245 2755 56172046
Judgement impaired 11.86 10.60 10 117256 603 56174198
Brain stem syndrome 11.85 10.60 8 117258 344 56174457
Skin disorder 11.84 10.60 23 117243 26286 56148515
Presyncope 11.83 10.60 22 117244 25560 56149241
Reproductive tract disorder 11.82 10.60 6 117260 150 56174651
Hyperaldosteronism 11.81 10.60 7 117259 239 56174562
Infusion site pain 11.80 10.60 7 117259 13755 56161046
Gastric disorder 11.76 10.60 33 117233 33177 56141624
Regressive behaviour 11.75 10.60 6 117260 152 56174649
Colitis 11.74 10.60 46 117220 41765 56133036
Inhibitory drug interaction 11.70 10.60 19 117247 2325 56172476
Injection site urticaria 11.69 10.60 6 117260 12777 56162024
Tooth development disorder 11.67 10.60 4 117262 35 56174766
Post-anoxic myoclonus 11.67 10.60 4 117262 35 56174766
Toothache 11.66 10.60 12 117254 17868 56156933
Bone density decreased 11.65 10.60 6 117260 12754 56162047
Electrocardiogram J wave 11.65 10.60 3 117263 8 56174793
Upper gastrointestinal haemorrhage 11.63 10.60 11 117255 17043 56157758
Haemorrhoids 11.62 10.60 15 117251 20191 56154610
Developmental hip dysplasia 11.61 10.60 14 117252 1297 56173504
Homicidal ideation 11.61 10.60 16 117250 1692 56173109
Blood cholesterol increased 11.60 10.60 96 117170 72483 56102318
Movement disorder 11.54 10.60 74 117192 19124 56155677
Device difficult to use 11.52 10.60 4 117262 10757 56164044
Paraesthesia oral 11.50 10.60 8 117258 14441 56160360
Social problem 11.50 10.60 11 117255 783 56174018
Metastases to lung 11.48 10.60 5 117261 11713 56163088
Congenital tracheomalacia 11.47 10.60 4 117262 37 56174764
Slow response to stimuli 11.46 10.60 12 117254 952 56173849
Hernia 11.46 10.60 4 117262 10719 56164082
Sudden death 11.43 10.60 45 117221 9580 56165221
Amino acid level increased 11.43 10.60 8 117258 365 56174436
Congenital floppy infant 11.39 10.60 3 117263 9 56174792
Congenital gastric anomaly 11.39 10.60 3 117263 9 56174792
Persistent left superior vena cava 11.38 10.60 4 117262 38 56174763
Intention tremor 11.35 10.60 8 117258 369 56174432
Electrocardiogram abnormal 11.28 10.60 40 117226 8104 56166697
Nikolsky's sign 11.25 10.60 5 117261 92 56174709
Eosinophilic myocarditis 11.24 10.60 8 117258 375 56174426
Teratogenicity 11.24 10.60 7 117259 262 56174539
Anomaly of external ear congenital 11.24 10.60 6 117260 167 56174634
Eosinophilic pneumonia 11.22 10.60 17 117249 1960 56172841
Histiocytic necrotising lymphadenitis 11.20 10.60 4 117262 40 56174761
Palatal disorder 11.17 10.60 7 117259 265 56174536
Glioblastoma multiforme 11.16 10.60 11 117255 812 56173989
Ageusia 11.16 10.60 6 117260 12445 56162356
Postictal paralysis 11.15 10.60 5 117261 94 56174707
Antidepressant drug level increased 11.14 10.60 7 117259 266 56174535
Viral infection 11.12 10.60 32 117234 31914 56142887
Dissociative disorder 11.12 10.60 7 117259 267 56174534
Hyporesponsive to stimuli 11.12 10.60 12 117254 986 56173815
Neutrophilia 11.08 10.60 25 117241 3908 56170893
Oppositional defiant disorder 11.02 10.60 4 117262 42 56174759
Flight of ideas 11.02 10.60 8 117258 387 56174414
Congenital nail disorder 10.96 10.60 5 117261 98 56174703
Enanthema 10.95 10.60 8 117258 391 56174410
Congenital oesophageal anomaly 10.93 10.60 3 117263 11 56174790
Carpal tunnel syndrome 10.93 10.60 13 117253 18131 56156670
Ventricular arrhythmia 10.92 10.60 23 117243 3431 56171370
Acute myocardial infarction 10.91 10.60 30 117236 30363 56144438
Delusional disorder, unspecified type 10.91 10.60 8 117258 393 56174408
Blood osmolarity increased 10.89 10.60 6 117260 178 56174623
Delusion of reference 10.87 10.60 5 117261 100 56174701
Parkinsonian rest tremor 10.87 10.60 5 117261 100 56174701
Device dislocation 10.85 10.60 19 117247 22587 56152214
Live birth 10.83 10.60 74 117192 19531 56155270
Procalcitonin increased 10.81 10.60 11 117255 844 56173957
Peripheral nerve injury 10.75 10.60 8 117258 402 56174399
Myoglobinuria 10.73 10.60 7 117259 284 56174517
Toe walking 10.73 10.60 3 117263 12 56174789
Impaired gastric emptying 10.71 10.60 3 117263 9260 56165541
Rickets 10.70 10.60 4 117262 46 56174755
Alanine aminotransferase increased 10.66 10.60 263 117003 93399 56081402
Gestational diabetes 10.65 10.60 39 117227 8025 56166776
Hepatic adenoma 10.62 10.60 7 117259 289 56174512

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1915.26 11.58 2192 127328 97576 31470248
Hyperammonaemia 1204.38 11.58 551 128969 5282 31562542
Drug interaction 1057.84 11.58 2504 127016 206039 31361785
Epilepsy 1010.27 11.58 772 128748 20269 31547555
Foetal anticonvulsant syndrome 947.12 11.58 300 129220 869 31566955
Dysmorphism 942.64 11.58 384 129136 2688 31565136
Aggression 863.69 11.58 906 128614 36385 31531439
Hyperammonaemic encephalopathy 782.78 11.58 307 129213 1919 31565905
Status epilepticus 730.17 11.58 510 129010 11596 31556228
Neuroleptic malignant syndrome 710.42 11.58 573 128947 16296 31551528
Foetal exposure during pregnancy 682.36 11.58 838 128682 40038 31527786
Autism spectrum disorder 587.79 11.58 249 129271 1946 31565878
Somnolence 541.28 11.58 1230 128290 98215 31469609
Speech disorder developmental 483.94 11.58 214 129306 1877 31565947
Generalised tonic-clonic seizure 480.42 11.58 495 129025 19436 31548388
Mania 447.43 11.58 340 129180 8837 31558987
Developmental delay 445.02 11.58 216 129304 2389 31565435
Dyspnoea 439.48 11.58 455 129065 343024 31224800
Learning disorder 411.69 11.58 157 129363 899 31566925
Abnormal behaviour 411.16 11.58 497 129023 23331 31544493
Sopor 408.84 11.58 355 129165 11197 31556627
Psychomotor retardation 396.96 11.58 215 129305 3037 31564787
Ammonia increased 393.25 11.58 232 129288 3895 31563929
Diarrhoea 386.50 11.58 527 128993 351882 31215942
Agitation 384.03 11.58 747 128773 53422 31514402
Psychotic disorder 383.03 11.58 464 129056 21829 31545995
Intellectual disability 364.63 11.58 150 129370 1079 31566745
Extrapyramidal disorder 361.50 11.58 334 129186 11444 31556380
Depression 352.06 11.58 988 128532 89827 31477997
Sedation 347.63 11.58 408 129112 18557 31549267
Cognitive disorder 338.96 11.58 462 129058 24461 31543363
Psychomotor skills impaired 335.78 11.58 190 129330 2937 31564887
Language disorder 335.68 11.58 167 129353 1956 31565868
Parkinsonism 326.91 11.58 262 129258 7374 31560450
Behaviour disorder 324.14 11.58 209 129311 4138 31563686
Granulocytopenia 317.40 11.58 235 129285 5864 31561960
Febrile neutropenia 295.23 11.58 68 129452 121781 31446043
Death 292.43 11.58 652 128868 359917 31207907
Petit mal epilepsy 292.08 11.58 169 129351 2731 31565093
Arthralgia 291.57 11.58 127 129393 151297 31416527
Disturbance in attention 287.05 11.58 404 129116 22046 31545778
Acute kidney injury 255.27 11.58 472 129048 279242 31288582
Coma 250.58 11.58 533 128987 40617 31527207
Multiple-drug resistance 249.84 11.58 180 129340 4300 31563524
Psychomotor hyperactivity 248.22 11.58 238 129282 8549 31559275
Attention deficit hyperactivity disorder 244.85 11.58 141 129379 2257 31565567
Nausea 238.78 11.58 570 128950 307377 31260447
Antipsychotic drug level increased 235.26 11.58 157 129363 3301 31564523
Fatigue 234.98 11.58 653 128867 334553 31233271
Toxicity to various agents 234.81 11.58 1403 128117 180084 31387740
Congenital nose malformation 232.82 11.58 68 129452 134 31567690
Irritability 232.66 11.58 370 129150 22519 31545305
Dysgraphia 232.65 11.58 132 129388 2051 31565773
Hypospadias 230.31 11.58 149 129371 2967 31564857
Salivary hypersecretion 229.52 11.58 216 129304 7576 31560248
Anaemia 228.70 11.58 324 129196 213198 31354626
Schizophrenia 227.30 11.58 250 129270 10580 31557244
Ataxia 222.95 11.58 269 129251 12594 31555230
Drug level increased 220.06 11.58 337 129183 19849 31547975
Atrial fibrillation 213.32 11.58 99 129421 113684 31454140
Intentional self-injury 212.31 11.58 267 129253 13048 31554776
Intentional overdose 206.13 11.58 495 129025 40894 31526930
Akathisia 198.36 11.58 193 129327 7060 31560764
Myocardial infarction 191.55 11.58 113 129407 113341 31454483
Tremor 191.06 11.58 716 128804 75704 31492120
Pain 190.51 11.58 293 129227 186466 31381358
Plasma cell myeloma 189.79 11.58 10 129510 56521 31511303
Depressed level of consciousness 189.37 11.58 459 129061 38142 31529682
Hypertelorism 188.78 11.58 75 129445 487 31567337
Suicide attempt 188.20 11.58 448 129072 36800 31531024
Cardiac failure congestive 184.97 11.58 48 129472 79339 31488485
Drug level decreased 184.05 11.58 181 129339 6709 31561115
Speech disorder 183.97 11.58 344 129176 23857 31543967
Rheumatoid arthritis 179.97 11.58 3 129517 47806 31520018
Mental impairment 179.52 11.58 208 129312 9324 31558500
Tardive dyskinesia 177.09 11.58 161 129359 5398 31562426
Pneumonia 177.08 11.58 738 128782 334574 31233250
Hypotonia 176.95 11.58 180 129340 6953 31560871
Overdose 176.14 11.58 749 128771 83915 31483909
Electroencephalogram abnormal 175.01 11.58 113 129407 2242 31565582
Pain in extremity 174.30 11.58 132 129388 116071 31451753
Enuresis 172.75 11.58 109 129411 2075 31565749
Neuropathy peripheral 171.98 11.58 48 129472 75601 31492223
Anticonvulsant drug level increased 171.57 11.58 96 129424 1450 31566374
Catatonia 164.38 11.58 145 129375 4669 31563155
Delusion 162.45 11.58 222 129298 11775 31556049
Gastrointestinal haemorrhage 162.30 11.58 67 129453 82482 31485342
Partial seizures 162.22 11.58 138 129382 4228 31563596
Blood creatine phosphokinase increased 160.74 11.58 455 129065 41519 31526305
Astigmatism 160.50 11.58 81 129439 980 31566844
Dystonia 158.20 11.58 202 129318 10023 31557801
Paranoia 156.23 11.58 204 129316 10351 31557473
Malignant neoplasm progression 153.88 11.58 65 129455 78933 31488891
Muscle rigidity 153.88 11.58 196 129324 9701 31558123
Hallucination, auditory 152.98 11.58 200 129320 10160 31557664
Anticonvulsant drug level decreased 152.96 11.58 78 129442 966 31566858
Disease progression 148.61 11.58 93 129427 90371 31477453
Dyspraxia 148.04 11.58 58 129462 361 31567463
Motor developmental delay 147.75 11.58 66 129454 594 31567230
Talipes 145.68 11.58 92 129428 1754 31566070
Antipsychotic drug level below therapeutic 145.60 11.58 95 129425 1920 31565904
Myoclonic epilepsy 145.48 11.58 77 129443 1035 31566789
Product residue present 142.84 11.58 104 129416 2526 31565298
Product substitution issue 139.14 11.58 182 129338 9250 31558574
Wrong patient received product 138.55 11.58 101 129419 2458 31565366
Bipolar disorder 136.91 11.58 117 129403 3607 31564217
Joint swelling 135.03 11.58 27 129493 53404 31514420
Delirium 134.88 11.58 424 129096 40997 31526827
Neurodevelopmental disorder 133.84 11.58 54 129466 367 31567457
Dyskinesia 132.04 11.58 275 129245 20635 31547189
Foot deformity 131.84 11.58 120 129400 4029 31563795
Asthenia 131.64 11.58 474 129046 224281 31343543
Peripheral swelling 130.32 11.58 57 129463 67808 31500016
Mental disorder 130.18 11.58 216 129304 13618 31554206
Strabismus 129.15 11.58 81 129439 1525 31566299
Learning disability 129.01 11.58 50 129470 301 31567523
Interstitial lung disease 128.74 11.58 45 129475 61358 31506466
Treatment noncompliance 128.71 11.58 308 129212 25376 31542448
Cryptorchism 127.48 11.58 87 129433 1900 31565924
Encephalopathy 126.25 11.58 354 129166 32120 31535704
Myopia 125.57 11.58 69 129451 1004 31566820
Schizoaffective disorder 124.94 11.58 73 129447 1202 31566622
Cough 123.92 11.58 226 129294 134588 31433236
Euphoric mood 123.57 11.58 125 129395 4795 31563029
Renal failure 123.22 11.58 196 129324 123134 31444690
Fanconi syndrome 121.66 11.58 79 129441 1583 31566241
Lip disorder 121.25 11.58 52 129468 420 31567404
Altered state of consciousness 120.44 11.58 266 129254 20785 31547039
Infusion related reaction 119.95 11.58 25 129495 48030 31519794
Suicidal ideation 119.75 11.58 374 129146 36032 31531792
Prostate cancer 119.19 11.58 9 129511 37592 31530232
Joint laxity 117.98 11.58 49 129471 362 31567462
Restlessness 117.98 11.58 281 129239 23080 31544744
Communication disorder 117.69 11.58 90 129430 2360 31565464
Educational problem 117.23 11.58 53 129467 492 31567332
Pruritus 116.67 11.58 208 129312 124959 31442865
Thrombosis 115.81 11.58 22 129498 45129 31522695
Chest pain 114.83 11.58 188 129332 116769 31451055
Disorientation 112.57 11.58 328 129192 30416 31537408
Drug reaction with eosinophilia and systemic symptoms 112.56 11.58 323 129197 29695 31538129
Disinhibition 112.28 11.58 91 129429 2602 31565222
Congenital oral malformation 111.74 11.58 26 129494 6 31567818
Hypotonia neonatal 110.26 11.58 68 129452 1241 31566583
Sudden unexplained death in epilepsy 109.02 11.58 48 129472 416 31567408
Bradyphrenia 108.98 11.58 111 129409 4293 31563531
Myoclonus 108.97 11.58 201 129319 13789 31554035
Dysarthria 108.16 11.58 332 129188 31685 31536139
Psoriasis 107.35 11.58 29 129491 46690 31521134
Abdominal pain 106.59 11.58 278 129242 145674 31422150
Myocarditis 105.59 11.58 181 129339 11719 31556105
Obsessive-compulsive disorder 105.37 11.58 115 129405 4822 31563002
Coordination abnormal 103.99 11.58 138 129382 7113 31560711
Low set ears 103.46 11.58 46 129474 409 31567415
Myalgia 103.23 11.58 98 129422 77160 31490664
Drug ineffective 102.90 11.58 2222 127298 393351 31174473
Anticonvulsant drug level above therapeutic 102.30 11.58 51 129469 600 31567224
Hypertonia 101.83 11.58 102 129418 3866 31563958
Sepsis 101.58 11.58 302 129218 151627 31416197
Cardiac failure 101.48 11.58 121 129399 85832 31481992
Oedema peripheral 101.02 11.58 184 129336 109655 31458169
Anticonvulsant drug level below therapeutic 100.38 11.58 50 129470 587 31567237
Pectus excavatum 100.32 11.58 37 129483 190 31567634
Drooling 99.29 11.58 90 129430 3005 31564819
Priapism 97.54 11.58 107 129413 4513 31563311
Thinking abnormal 95.66 11.58 116 129404 5457 31562367
Focal dyscognitive seizures 95.19 11.58 62 129458 1249 31566575
Congenital foot malformation 95.09 11.58 42 129478 367 31567457
Back pain 93.89 11.58 191 129329 109222 31458602
Drug level below therapeutic 93.12 11.58 109 129411 4939 31562885
Fine motor delay 92.44 11.58 36 129484 220 31567604
Acute myocardial infarction 92.44 11.58 46 129474 50777 31517047
Scoliosis 92.18 11.58 80 129440 2519 31565305
Congenital hand malformation 92.06 11.58 46 129474 544 31567280
Pneumonia aspiration 91.86 11.58 357 129163 38369 31529455
Mucosal inflammation 89.95 11.58 16 129504 34411 31533413
Hypermetropia 89.84 11.58 42 129478 424 31567400
Prescribed overdose 89.83 11.58 146 129374 9046 31558778
Coronary artery disease 89.59 11.58 38 129482 46049 31521775
Chest discomfort 89.31 11.58 45 129475 49324 31518500
Antipsychotic drug level above therapeutic 88.75 11.58 57 129463 1120 31566704
Ear disorder 86.87 11.58 60 129460 1337 31566487
Hyperkalaemia 85.53 11.58 82 129438 64269 31503555
Pulmonary embolism 85.10 11.58 126 129394 81520 31486304
Psychogenic seizure 83.80 11.58 37 129483 323 31567501
Dizziness 83.48 11.58 475 129045 198672 31369152
Echolalia 83.09 11.58 35 129485 269 31567555
Disturbance in social behaviour 83.01 11.58 64 129456 1699 31566125
Prominent epicanthal folds 82.82 11.58 30 129490 145 31567679
Blood pressure increased 81.92 11.58 124 129396 79509 31488315
Chills 81.68 11.58 110 129410 74040 31493784
Asterixis 81.62 11.58 54 129466 1118 31566706
Affect lability 81.53 11.58 85 129435 3380 31564444
Developmental coordination disorder 81.03 11.58 30 129490 156 31567668
Fine motor skill dysfunction 81.00 11.58 62 129458 1628 31566196
Obesity 80.88 11.58 155 129365 10945 31556879
Increased appetite 80.80 11.58 114 129406 6230 31561594
Hypothermia 80.55 11.58 142 129378 9402 31558422
Ligament laxity 80.12 11.58 20 129500 13 31567811
Impulsive behaviour 79.68 11.58 66 129454 1947 31565877
Anger 79.14 11.58 154 129366 10999 31556825
Eosinophilia 78.41 11.58 241 129279 23012 31544812
Clinodactyly 78.39 11.58 32 129488 225 31567599
Drug withdrawal convulsions 76.98 11.58 52 129468 1116 31566708
Ascites 76.29 11.58 36 129484 40977 31526847
Hypomania 75.67 11.58 67 129453 2168 31565656
Epistaxis 75.46 11.58 65 129455 53642 31514182
Oppositional defiant disorder 75.36 11.58 39 129481 499 31567325
Stereotypy 73.82 11.58 42 129478 656 31567168
Nystagmus 73.42 11.58 91 129429 4379 31563445
Bipolar I disorder 72.96 11.58 44 129476 770 31567054
Tonic convulsion 72.76 11.58 49 129471 1046 31566778
Dyspnoea exertional 72.37 11.58 34 129486 38803 31529021
COVID-19 71.52 11.58 71 129449 54750 31513074
Therapeutic product effect variable 71.47 11.58 61 129459 1877 31565947
Hypernatraemia 71.22 11.58 119 129401 7544 31560280
Urticaria 71.09 11.58 78 129442 57439 31510385
Congenital anomaly 70.71 11.58 52 129468 1283 31566541
Renal impairment 70.49 11.58 155 129365 86194 31481630
Dyslexia 70.32 11.58 32 129488 302 31567522
Personal relationship issue 70.27 11.58 31 129489 270 31567554
Atonic seizures 70.19 11.58 30 129490 240 31567584
Weight decreased 70.00 11.58 376 129144 159576 31408248
Headache 69.12 11.58 453 129067 183199 31384625
Oculogyric crisis 68.90 11.58 53 129467 1402 31566422
Persecutory delusion 68.87 11.58 65 129455 2287 31565537
Personality disorder 68.74 11.58 48 129472 1089 31566735
Muscle spasms 68.71 11.58 108 129412 68210 31499614
Microcephaly 68.51 11.58 42 129478 758 31567066
Influenza 68.13 11.58 49 129471 44276 31523548
Hypermobility syndrome 68.03 11.58 32 129488 328 31567496
Neutrophil count increased 67.63 11.58 178 129342 15553 31552271
Stevens-Johnson syndrome 67.12 11.58 189 129331 17183 31550641
Loss of personal independence in daily activities 66.44 11.58 260 129260 28028 31539796
Craniosynostosis 66.05 11.58 31 129489 316 31567508
Haematochezia 64.49 11.58 43 129477 40421 31527403
Psychiatric decompensation 64.45 11.58 58 129462 1918 31565906
Sedation complication 64.44 11.58 51 129469 1408 31566416
Plagiocephaly 64.44 11.58 35 129485 497 31567327
Decreased eye contact 64.36 11.58 34 129486 455 31567369
Confusional state 64.12 11.58 829 128691 132505 31435319
Cerebrovascular accident 63.79 11.58 144 129376 79340 31488484
Bradykinesia 63.67 11.58 76 129444 3516 31564308
Abdominal pain upper 63.58 11.58 102 129418 63900 31503924
Dysphoria 63.55 11.58 60 129460 2112 31565712
Hepatic function abnormal 63.19 11.58 334 129186 40888 31526936
Ear malformation 63.16 11.58 29 129491 280 31567544
Hypersensitivity 63.11 11.58 81 129439 55662 31512162
Toxic encephalopathy 63.02 11.58 88 129432 4762 31563062
Nasal disorder 62.74 11.58 54 129466 1681 31566143
Pancytopenia 62.39 11.58 168 129352 87148 31480676
Infantile spasms 62.10 11.58 29 129491 292 31567532
Psychiatric symptom 61.91 11.58 72 129448 3239 31564585
Fluid retention 61.68 11.58 13 129507 24789 31543035
Herpes zoster 61.18 11.58 27 129493 31966 31535858
Erythema 61.06 11.58 150 129370 80255 31487569
Arthritis 61.04 11.58 18 129502 27367 31540457
Gaze palsy 60.16 11.58 49 129471 1411 31566413
Eosinophilic pleural effusion 59.79 11.58 26 129494 218 31567606
Stupor 59.68 11.58 65 129455 2719 31565105
General physical health deterioration 59.35 11.58 250 129270 113185 31454639
Sleep disorder 59.32 11.58 239 129281 26109 31541715
Serotonin syndrome 59.09 11.58 190 129330 18583 31549241
Melaena 58.70 11.58 30 129490 32624 31535200
Dehydration 58.39 11.58 269 129251 118842 31448982
Nose deformity 58.29 11.58 24 129496 173 31567651
Hypoaesthesia 57.83 11.58 87 129433 55935 31511889
Completed suicide 57.37 11.58 599 128921 90915 31476909
Asocial behaviour 57.36 11.58 18 129502 50 31567774
Sinusitis 57.14 11.58 40 129480 36656 31531168
Psoriatic arthropathy 57.11 11.58 7 129513 19876 31547948
Brain oedema 57.01 11.58 147 129373 12685 31555139
Psychotic symptom 56.99 11.58 49 129471 1523 31566301
Antipsychotic drug level decreased 56.70 11.58 39 129481 863 31566961
Postictal psychosis 56.67 11.58 23 129497 159 31567665
Exposure during pregnancy 56.52 11.58 115 129405 8483 31559341
Syncope 56.37 11.58 170 129350 85012 31482812
Septic shock 56.28 11.58 116 129404 66042 31501782
Cytokine release syndrome 55.66 11.58 3 129517 16639 31551185
Blood creatinine increased 55.28 11.58 183 129337 88895 31478929
Angina pectoris 55.15 11.58 26 129494 29615 31538209
Encopresis 54.72 11.58 22 129498 148 31567676
Excessive eye blinking 54.50 11.58 31 129489 484 31567340
Weight increased 54.40 11.58 548 128972 82399 31485425
Pressure of speech 54.38 11.58 30 129490 440 31567384
Musculoskeletal pain 54.22 11.58 27 129493 29801 31538023
Upper gastrointestinal haemorrhage 53.99 11.58 14 129506 23169 31544655
White blood cell count increased 53.74 11.58 307 129213 38693 31529131
Hyperacusis 53.40 11.58 36 129484 770 31567054
Atrial septal defect 53.28 11.58 99 129421 6828 31560996
Basal cell carcinoma 53.20 11.58 6 129514 18173 31549651
Haemoptysis 52.94 11.58 33 129487 32156 31535668
Mental status changes 52.79 11.58 288 129232 35680 31532144
Knee deformity 52.56 11.58 32 129488 570 31567254
Hyperkinesia 52.39 11.58 48 129472 1625 31566199
Cogwheel rigidity 52.24 11.58 43 129477 1257 31566567
Congenital eye disorder 52.08 11.58 20 129500 117 31567707
Rash 51.72 11.58 550 128970 200936 31366888
Ear infection 51.67 11.58 113 129407 8768 31559056
Osteonecrosis of jaw 51.59 11.58 5 129515 17066 31550758
Anxiety 51.58 11.58 584 128936 90449 31477375
Reading disorder 51.50 11.58 30 129490 491 31567333
Hyperprolactinaemia 51.08 11.58 45 129475 1446 31566378
Rectal haemorrhage 50.91 11.58 44 129476 36260 31531564
Chronic kidney disease 50.90 11.58 48 129472 37927 31529897
Urinary incontinence 50.67 11.58 171 129349 17149 31550675
Social avoidant behaviour 50.55 11.58 62 129458 2951 31564873
Motor dysfunction 50.53 11.58 92 129428 6247 31561577
Swelling 50.33 11.58 47 129473 37311 31530513
Drug abuse 50.17 11.58 564 128956 87194 31480630
Depressive symptom 49.99 11.58 52 129468 2062 31565762
Differential white blood cell count abnormal 49.80 11.58 42 129478 1271 31566553
Arthropathy 49.75 11.58 18 129502 24033 31543791
Cerebral atrophy 49.66 11.58 73 129447 4142 31563682
Pneumonitis 49.62 11.58 32 129488 30620 31537204
Camptodactyly congenital 49.36 11.58 19 129501 112 31567712
Lethargy 49.25 11.58 298 129222 38343 31529481
Anaphylactic reaction 49.01 11.58 30 129490 29523 31538301
Cerebellar atrophy 48.97 11.58 29 129491 490 31567334
Arnold-Chiari malformation 48.78 11.58 25 129495 313 31567511
Cytomegalovirus infection 48.60 11.58 20 129500 24687 31543137
Malaise 48.23 11.58 448 129072 168063 31399761
High arched palate 47.80 11.58 16 129504 58 31567766
Spina bifida 47.69 11.58 25 129495 329 31567495
Bruxism 47.64 11.58 45 129475 1585 31566239
Drug level changed 47.63 11.58 25 129495 330 31567494
Multiple congenital abnormalities 47.61 11.58 29 129491 517 31567307
Cerebral ventricle dilatation 47.13 11.58 35 129485 877 31566947
Gait disturbance 47.03 11.58 504 129016 76991 31490833
Pancreatitis acute 46.73 11.58 218 129302 25382 31542442
Pneumocystis jirovecii pneumonia 46.56 11.58 9 129511 18242 31549582
Leukopenia 46.43 11.58 399 129121 57429 31510395
Congenital eyelid malformation 46.30 11.58 17 129503 86 31567738
Posture abnormal 45.66 11.58 49 129471 2015 31565809
Faecaloma 45.55 11.58 74 129446 4582 31563242
Emotional disorder 45.46 11.58 79 129441 5170 31562654
Diabetes insipidus 45.44 11.58 54 129466 2486 31565338
Hyperosmolar state 45.42 11.58 25 129495 365 31567459
Congenital hair disorder 45.04 11.58 10 129510 0 31567824
Paraesthesia 44.63 11.58 102 129418 55969 31511855
Normal pressure hydrocephalus 44.24 11.58 19 129501 154 31567670
Memory impairment 44.19 11.58 287 129233 37843 31529981
Acute myeloid leukaemia 44.01 11.58 11 129509 18661 31549163
Pleurothotonus 43.89 11.58 36 129484 1047 31566777
Abdominal discomfort 43.36 11.58 91 129429 51476 31516348
Affective disorder 43.00 11.58 64 129456 3672 31564152
Homicidal ideation 42.96 11.58 53 129467 2538 31565286
Stomatitis 42.91 11.58 59 129461 39379 31528445
Haemorrhage 42.84 11.58 80 129440 47254 31520570
Brugada syndrome 42.68 11.58 30 129490 688 31567136
Tooth malformation 42.44 11.58 19 129501 172 31567652
Colitis 41.81 11.58 46 129474 33841 31533983
Autonomic nervous system imbalance 41.77 11.58 51 129469 2416 31565408
Injection site pain 41.65 11.58 48 129472 34586 31533238
Nipple disorder 41.60 11.58 19 129501 181 31567643
Confabulation 41.35 11.58 17 129503 122 31567702
Eosinophil count decreased 41.33 11.58 36 129484 1139 31566685
Physical assault 41.28 11.58 35 129485 1067 31566757
Choreoathetosis 41.16 11.58 34 129486 999 31566825
Logorrhoea 40.99 11.58 49 129471 2270 31565554
Palmar-plantar erythrodysaesthesia syndrome 40.87 11.58 7 129513 15476 31552348
Neoplasm progression 40.54 11.58 16 129504 20256 31547568
Tumour lysis syndrome 40.51 11.58 7 129513 15378 31552446
Haematuria 40.41 11.58 80 129440 46234 31521590
Product dose omission issue 40.39 11.58 259 129261 105327 31462497
Blood prolactin increased 40.31 11.58 41 129479 1583 31566241
Chorea 40.02 11.58 33 129487 967 31566857
Homicide 39.93 11.58 32 129488 900 31566924
Apathy 39.45 11.58 84 129436 6398 31561426
Pancreatitis 38.89 11.58 265 129255 35506 31532318
Seizure cluster 38.78 11.58 16 129504 116 31567708
Executive dysfunction 38.75 11.58 19 129501 215 31567609
Synovitis 38.75 11.58 3 129517 12280 31555544
Heart rate decreased 38.74 11.58 35 129485 28231 31539593
Respiratory failure 38.73 11.58 249 129271 101200 31466624
Anisometropia 38.24 11.58 13 129507 50 31567774
Flushing 38.17 11.58 40 129480 30088 31537736
Angioedema 37.89 11.58 49 129471 33569 31534255
Lung disorder 37.56 11.58 46 129474 32266 31535558
Apraxia 37.09 11.58 35 129485 1231 31566593
Congenital myopia 37.09 11.58 13 129507 56 31567768
Acidosis hyperchloraemic 36.93 11.58 22 129498 376 31567448
Bacteraemia 36.81 11.58 13 129507 17621 31550203
Oedema 36.72 11.58 74 129446 42487 31525337
Bronchiolitis 36.71 11.58 52 129468 2852 31564972
Delusional disorder, unspecified type 36.61 11.58 27 129493 669 31567155
Osteoarthritis 36.60 11.58 16 129504 19051 31548773
Sexually inappropriate behaviour 36.53 11.58 23 129497 436 31567388
Inappropriate antidiuretic hormone secretion 36.52 11.58 116 129404 11271 31556553
Renal disorder 36.51 11.58 26 129494 23619 31544205
Haemoglobin decreased 36.47 11.58 290 129230 112385 31455439
Bronchopulmonary aspergillosis 36.35 11.58 6 129514 13628 31554196
International normalised ratio increased 36.21 11.58 82 129438 45141 31522683
Monocyte count increased 36.15 11.58 64 129456 4251 31563573
Cellulitis 36.11 11.58 90 129430 47928 31519896
Carnitine decreased 36.03 11.58 8 129512 0 31567824
Dysgeusia 35.97 11.58 26 129494 23440 31544384
Crying 35.77 11.58 74 129446 5523 31562301
Necrosis ischaemic 35.36 11.58 18 129502 222 31567602
Antisocial behaviour 35.29 11.58 20 129500 310 31567514
Transient ischaemic attack 35.15 11.58 28 129492 24028 31543796
Pharyngeal disorder 35.02 11.58 26 129494 651 31567173
Torticollis 35.01 11.58 32 129488 1080 31566744
Dyscalculia 34.90 11.58 13 129507 69 31567755
Full blood count decreased 34.86 11.58 12 129508 16528 31551296
Intelligence test abnormal 34.82 11.58 10 129510 18 31567806
Head titubation 34.57 11.58 20 129500 323 31567501
Bone pain 34.45 11.58 18 129502 19333 31548491
Mood altered 34.42 11.58 93 129427 8253 31559571
Abdominal distension 34.34 11.58 100 129420 50584 31517240
Laboratory test abnormal 34.24 11.58 17 129503 18797 31549027
Drop attacks 34.24 11.58 24 129496 548 31567276
Flight of ideas 34.19 11.58 20 129500 330 31567494
Emotional disorder of childhood 34.19 11.58 11 129509 34 31567790
Pyrexia 34.19 11.58 963 128557 302877 31264947
Anaphylactic shock 33.99 11.58 8 129512 14137 31553687
Hypotension 33.97 11.58 610 128910 204008 31363816
Social (pragmatic) communication disorder 33.86 11.58 13 129507 76 31567748
Atrial flutter 33.84 11.58 9 129511 14646 31553178
Congenital astigmatism 33.82 11.58 10 129510 21 31567803
Heart disease congenital 33.67 11.58 34 129486 1301 31566523
Arachnodactyly 33.50 11.58 8 129512 3 31567821
Congenital nail disorder 33.49 11.58 11 129509 37 31567787
Coloboma 33.29 11.58 15 129505 138 31567686
Gastrointestinal malformation 33.27 11.58 11 129509 38 31567786
Hypokalaemia 33.26 11.58 110 129410 53464 31514360
Drug intolerance 32.88 11.58 106 129414 51927 31515897
COVID-19 pneumonia 32.80 11.58 6 129514 12649 31555175
Pneumothorax 32.76 11.58 14 129506 16896 31550928
Prognathism 32.76 11.58 14 129506 112 31567712
Blood pressure fluctuation 32.56 11.58 27 129493 22709 31545115
Illiteracy 32.17 11.58 8 129512 5 31567819
Chronic obstructive pulmonary disease 32.16 11.58 87 129433 45079 31522745
Growth retardation 32.16 11.58 37 129483 1645 31566179
Inguinal hernia 32.12 11.58 81 129439 6894 31560930
Pulmonary fibrosis 31.95 11.58 14 129506 16646 31551178
Visuospatial deficit 31.90 11.58 13 129507 91 31567733
Postictal paralysis 31.89 11.58 17 129503 232 31567592
Hypertension 31.88 11.58 352 129168 127748 31440076
Neoplasm malignant 31.69 11.58 19 129501 18912 31548912
Soliloquy 31.63 11.58 20 129500 382 31567442
Delusion of grandeur 31.53 11.58 25 129495 692 31567132
Drug hypersensitivity 31.51 11.58 171 129349 72428 31495396
Nasal septum disorder 31.45 11.58 11 129509 47 31567777
Distractibility 31.28 11.58 19 129501 337 31567487
Acute coronary syndrome 31.19 11.58 7 129513 12782 31555042
Staphylococcal infection 31.18 11.58 48 129472 30584 31537240
Retinal coloboma 31.06 11.58 9 129511 17 31567807
Intentional product use issue 30.85 11.58 101 129419 49246 31518578
Perseveration 30.74 11.58 13 129507 101 31567723
Postictal state 30.72 11.58 25 129495 719 31567105
Febrile convulsion 30.60 11.58 23 129497 587 31567237
Night sweats 30.52 11.58 13 129507 15719 31552105
Dysmetria 30.44 11.58 21 129499 467 31567357
Congenital knee deformity 30.42 11.58 13 129507 104 31567720
Otitis media 30.38 11.58 45 129475 2571 31565253
Infection 30.29 11.58 203 129317 81728 31486096
Anion gap increased 30.23 11.58 36 129484 1661 31566163
Social problem 30.22 11.58 26 129494 809 31567015
Myelodysplastic syndrome 29.94 11.58 21 129499 19230 31548594
Mutism 29.85 11.58 25 129495 749 31567075
Angina unstable 29.68 11.58 5 129515 11190 31556634
Muscle tone disorder 29.64 11.58 14 129506 145 31567679
Nephrolithiasis 29.63 11.58 41 129479 27298 31540526
Decreased appetite 29.62 11.58 444 129076 152773 31415051
Paradoxical drug reaction 29.62 11.58 49 129471 3080 31564744
Gross motor delay 29.41 11.58 17 129503 274 31567550
Hepatic adenoma 29.31 11.58 10 129510 39 31567785
Medication error 29.25 11.58 176 129344 22596 31545228
Deep vein thrombosis 29.23 11.58 138 129382 60598 31507226
Developmental hip dysplasia 29.09 11.58 17 129503 280 31567544
Hot flush 28.93 11.58 15 129505 16181 31551643
Sluggishness 28.80 11.58 48 129472 3036 31564788
Toe walking 28.75 11.58 8 129512 12 31567812
Limb hypoplasia congenital 28.75 11.58 8 129512 12 31567812
Rhinorrhoea 28.65 11.58 31 129489 22981 31544843
Refraction disorder 28.42 11.58 9 129511 26 31567798
Coma scale abnormal 28.37 11.58 53 129467 3670 31564154
Neural tube defect 28.36 11.58 10 129510 44 31567780
Cerebral palsy 28.29 11.58 12 129508 94 31567730
Middle insomnia 28.26 11.58 71 129449 6028 31561796
Inflammation 28.23 11.58 37 129483 25204 31542620
Amblyopia 28.19 11.58 12 129508 95 31567729
Cardiogenic shock 28.10 11.58 30 129490 22378 31545446
Lymphocyte count increased 28.09 11.58 46 129474 2867 31564957
Dyslipidaemia 28.06 11.58 73 129447 6333 31561491
Dry skin 27.83 11.58 38 129482 25443 31542381
Hallucination, visual 27.73 11.58 133 129387 15661 31552163
Pelvic deformity 27.65 11.58 8 129512 15 31567809
Meningocele 27.46 11.58 9 129511 30 31567794
Anticonvulsant drug level abnormal 27.46 11.58 9 129511 30 31567794
Constipation 27.28 11.58 350 129170 123641 31444183
Retrognathia 27.25 11.58 16 129504 266 31567558
Convulsive threshold lowered 27.14 11.58 20 129500 495 31567329
Congenital genital malformation 27.06 11.58 12 129508 106 31567718
Intensive care unit acquired weakness 27.05 11.58 26 129494 936 31566888
Factor XIII deficiency 27.03 11.58 6 129514 0 31567824
Congenital neurological disorder 27.03 11.58 6 129514 0 31567824
Nasopharyngitis 26.88 11.58 150 129370 63095 31504729
Rash pruritic 26.86 11.58 35 129485 23903 31543921
Balance disorder 26.84 11.58 252 129268 37170 31530654
Blood potassium decreased 26.78 11.58 17 129503 16409 31551415
Duodenal ulcer 26.70 11.58 4 129516 9760 31558064
Phobia 26.68 11.58 13 129507 145 31567679
Clostridium difficile colitis 26.65 11.58 12 129508 14044 31553780
Inappropriate affect 26.49 11.58 21 129499 581 31567243
Brain malformation 26.49 11.58 12 129508 112 31567712
Frustration tolerance decreased 26.45 11.58 40 129480 2328 31565496
Speech sound disorder 26.45 11.58 13 129507 148 31567676
Device related infection 26.40 11.58 17 129503 16282 31551542
Scaphocephaly 26.38 11.58 8 129512 19 31567805
Metastases to bone 26.33 11.58 6 129514 10842 31556982
Choking 26.05 11.58 58 129462 4554 31563270
Localised infection 26.01 11.58 15 129505 15250 31552574
Cholestasis 25.81 11.58 39 129481 25036 31542788
Cleft palate 25.71 11.58 21 129499 607 31567217
Renal injury 25.69 11.58 6 129514 10659 31557165
Hypotelorism of orbit 25.68 11.58 12 129508 121 31567703
Overweight 25.62 11.58 32 129488 1552 31566272
Aminoaciduria 25.60 11.58 12 129508 122 31567702
Gout 25.51 11.58 22 129498 18152 31549672
Osteomyelitis 25.51 11.58 14 129506 14629 31553195
Deformity thorax 25.45 11.58 9 129511 40 31567784
Tonic clonic movements 25.43 11.58 25 129495 926 31566898
Staring 25.40 11.58 30 129490 1372 31566452
Oligoasthenozoospermia 25.36 11.58 7 129513 10 31567814
Impaired reasoning 25.26 11.58 12 129508 126 31567698
Urinary tract infection 25.25 11.58 197 129323 76672 31491152
Ventricular tachycardia 25.23 11.58 36 129484 23665 31544159
Cerebral infarction 25.22 11.58 42 129478 25935 31541889
Bicuspid aortic valve 25.22 11.58 14 129506 208 31567616
Tic 25.17 11.58 35 129485 1886 31565938
Dacryostenosis congenital 25.10 11.58 9 129511 42 31567782
Foetal growth restriction 25.04 11.58 51 129469 3764 31564060
Negativism 24.96 11.58 17 129503 370 31567454
Pulmonary hypertension 24.94 11.58 27 129493 20014 31547810
Angular cheilitis 24.94 11.58 13 129507 169 31567655
Diffuse large B-cell lymphoma 24.92 11.58 3 129517 8638 31559186
Patient isolation 24.80 11.58 8 129512 25 31567799
Judgement impaired 24.64 11.58 20 129500 573 31567251
Choroidal coloboma 24.61 11.58 6 129514 3 31567821
Microstomia 24.61 11.58 6 129514 3 31567821
Strabismus congenital 24.57 11.58 8 129512 26 31567798
Post-injection delirium sedation syndrome 24.55 11.58 18 129502 442 31567382
Food interaction 24.54 11.58 24 129496 883 31566941
Hypervolaemia 24.53 11.58 23 129497 18228 31549596
Unresponsive to stimuli 24.49 11.58 185 129335 25615 31542209
Renal tubular necrosis 24.44 11.58 15 129505 14744 31553080
Anomaly of external ear congenital 24.43 11.58 11 129509 101 31567723
Neuralgia 24.34 11.58 9 129511 11857 31555967
Faeces discoloured 24.28 11.58 13 129507 13773 31554051
Metabolic acidosis 24.27 11.58 258 129262 39319 31528505
Pulmonary mass 24.18 11.58 8 129512 11298 31556526
Depressed mood 23.97 11.58 138 129382 17437 31550387
Frequent bowel movements 23.91 11.58 6 129514 10153 31557671
Congenital scoliosis 23.84 11.58 10 129510 76 31567748
Condition aggravated 23.80 11.58 856 128664 163153 31404671
Muscular weakness 23.77 11.58 163 129357 65285 31502539
Partial seizures with secondary generalisation 23.75 11.58 15 129505 286 31567538
Aptyalism 23.75 11.58 15 129505 286 31567538
Eosinophil count increased 23.74 11.58 78 129442 7713 31560111
Adrenal insufficiency 23.70 11.58 11 129509 12648 31555176
Failure to suspend medication 23.70 11.58 17 129503 403 31567421
Water intoxication 23.66 11.58 17 129503 404 31567420
Tearfulness 23.61 11.58 34 129486 1893 31565931
Myelosuppression 23.57 11.58 16 129504 14904 31552920
Selective eating disorder 23.54 11.58 32 129488 1688 31566136
Blood pressure systolic increased 23.39 11.58 27 129493 19443 31548381
Blood bilirubin increased 23.31 11.58 70 129450 35066 31532758
Drug resistance 23.30 11.58 170 129350 23283 31544541
Mood swings 23.23 11.58 75 129445 7349 31560475
Wrong product administered 23.20 11.58 58 129462 4910 31562914
Flatulence 23.06 11.58 26 129494 18922 31548902
Clostridium difficile infection 22.96 11.58 22 129498 17257 31550567
Metabolic syndrome 22.80 11.58 30 129490 1533 31566291
Ventricular septal defect 22.78 11.58 48 129472 3629 31564195
Grandiosity 22.74 11.58 15 129505 309 31567515
Pulmonary arterial hypertension 22.73 11.58 6 129514 9815 31558009
Oesophageal carcinoma 22.65 11.58 3 129517 8030 31559794
Nephropathy toxic 22.64 11.58 9 129511 11344 31556480
Meningomyelocele 22.62 11.58 12 129508 162 31567662
Resting tremor 22.61 11.58 20 129500 646 31567178
Patent ductus arteriosus 22.54 11.58 44 129476 3149 31564675
Pneumonia bacterial 22.52 11.58 7 129513 10289 31557535
Aphasia 22.47 11.58 149 129371 19782 31548042
Self-injurious ideation 22.44 11.58 30 129490 1557 31566267
Candida infection 22.43 11.58 20 129500 16238 31551586
Feeling hot 22.36 11.58 20 129500 16213 31551611
Transplant rejection 22.34 11.58 6 129514 9702 31558122
Bone marrow failure 22.24 11.58 51 129469 27957 31539867
Oropharyngeal discomfort 22.23 11.58 40 129480 2691 31565133
Incontinence 22.19 11.58 60 129460 5326 31562498
Squamous cell carcinoma 22.18 11.58 8 129512 10703 31557121
Disorganised speech 22.15 11.58 21 129499 743 31567081
Shock haemorrhagic 22.12 11.58 7 129513 10170 31557654
Squamous cell carcinoma of skin 22.11 11.58 7 129513 10167 31557657
Porphyria acute 22.08 11.58 15 129505 325 31567499
Cardiac disorder 22.01 11.58 84 129436 39130 31528694
Febrile bone marrow aplasia 21.96 11.58 3 129517 7843 31559981
Diabetic hyperosmolar coma 21.89 11.58 16 129504 391 31567433
Subacute endocarditis 21.70 11.58 8 129512 41 31567783
C-reactive protein abnormal 21.67 11.58 3 129517 7766 31560058
Depression suicidal 21.67 11.58 30 129490 1610 31566214
Salivary gland enlargement 21.67 11.58 7 129513 22 31567802
Acute hepatic failure 21.65 11.58 107 129413 12752 31555072
Blood osmolarity decreased 21.64 11.58 18 129502 534 31567290
Congenital nipple anomaly 21.57 11.58 6 129514 9 31567815
Pleural effusion 21.47 11.58 199 129321 74721 31493103
Clonic convulsion 21.40 11.58 19 129501 617 31567207
Decreased gait velocity 21.38 11.58 11 129509 139 31567685
Cerebral haemorrhage 21.32 11.58 66 129454 32746 31535078
Graft versus host disease 21.30 11.58 8 129512 10439 31557385
Lymphoma 21.29 11.58 9 129511 10934 31556890
Head deformity 21.27 11.58 9 129511 70 31567754
Skin cancer 21.22 11.58 6 129514 9379 31558445
Impaired healing 21.22 11.58 16 129504 14116 31553708
Tachycardia 21.20 11.58 433 129087 75774 31492050
Diverticulitis 21.19 11.58 27 129493 18618 31549206
Conductive deafness 21.17 11.58 11 129509 142 31567682
Head discomfort 21.10 11.58 47 129473 3692 31564132
Blood lactic acid increased 21.09 11.58 64 129456 6066 31561758
Contusion 21.06 11.58 67 129453 32961 31534863
Joint hyperextension 21.05 11.58 10 129510 105 31567719
Ageusia 21.04 11.58 6 129514 9325 31558499
Brachydactyly 21.00 11.58 12 129508 189 31567635
Intestinal ischaemia 20.99 11.58 70 129450 6975 31560849
Throat irritation 20.98 11.58 6 129514 9308 31558516
Micrognathia 20.86 11.58 14 129506 297 31567527
Presyncope 20.85 11.58 24 129496 17304 31550520
Hyponatraemia 20.76 11.58 420 129100 73379 31494445
Retinogram abnormal 20.64 11.58 10 129510 110 31567714
Basilar artery occlusion 20.64 11.58 9 129511 76 31567748
Epidermolysis bullosa 20.56 11.58 10 129510 111 31567713
Hypoxia 20.48 11.58 121 129399 50192 31517632
Hyperthermia 20.36 11.58 88 129432 9916 31557908
Venoocclusive liver disease 20.35 11.58 3 129517 7409 31560415
Lennox-Gastaut syndrome 20.26 11.58 8 129512 51 31567773
Drug level above therapeutic 20.22 11.58 46 129474 3664 31564160
Madarosis 20.20 11.58 12 129508 204 31567620
Gastric volvulus 20.18 11.58 5 129515 3 31567821
Bronchopulmonary disease 20.18 11.58 5 129515 3 31567821
Tonsillitis 20.15 11.58 33 129487 2057 31565767
Heterophoria 20.15 11.58 9 129511 81 31567743
Blood triglycerides increased 20.14 11.58 108 129412 13289 31554535
Injection site swelling 20.11 11.58 8 129512 10079 31557745
Type 2 diabetes mellitus 20.11 11.58 116 129404 14668 31553156
Withdrawal syndrome 20.09 11.58 98 129422 11619 31556205
Delusional perception 20.02 11.58 11 129509 160 31567664
Haemorrhoids 19.93 11.58 13 129507 12369 31555455
Enterocolitis 19.85 11.58 3 129517 7271 31560553
Blood glucose increased 19.84 11.58 157 129363 60926 31506898
Hyperexplexia 19.82 11.58 7 129513 31 31567793
Haemangioma 19.76 11.58 30 129490 1752 31566072
Skin ulcer 19.69 11.58 32 129488 19953 31547871
Pasteurella infection 19.57 11.58 6 129514 15 31567809
Pain in jaw 19.55 11.58 13 129507 12242 31555582
Necrotising colitis 19.52 11.58 23 129497 1049 31566775
Brachycephaly 19.51 11.58 8 129512 57 31567767
Poverty of speech 19.41 11.58 12 129508 220 31567604
Dyspepsia 19.41 11.58 68 129452 32485 31535339
Verbal abuse 19.38 11.58 11 129509 171 31567653
Cholelithiasis 19.37 11.58 31 129489 19448 31548376
Brain stem auditory evoked response abnormal 19.30 11.58 6 129514 16 31567808
Trismus 19.29 11.58 35 129485 2370 31565454
Cataract 19.19 11.58 43 129477 23764 31544060
Hallucination 19.17 11.58 281 129239 46129 31521695
Hostility 19.14 11.58 20 129500 797 31567027
Ehlers-Danlos syndrome 19.13 11.58 7 129513 35 31567789
Sensory integrative dysfunction 19.13 11.58 7 129513 35 31567789
Developmental regression 19.13 11.58 7 129513 35 31567789
Myoglobinuria 19.10 11.58 19 129501 714 31567110
Kyphosis congenital 19.08 11.58 5 129515 5 31567819
Limb discomfort 19.05 11.58 9 129511 10240 31557584
Supernumerary nipple 18.97 11.58 7 129513 36 31567788
Hepatitis C virus test positive 18.96 11.58 13 129507 286 31567538
Rhabdomyolysis 18.94 11.58 365 129155 63216 31504608
Dissociation 18.86 11.58 25 129495 1287 31566537
Lower gastrointestinal haemorrhage 18.84 11.58 6 129514 8683 31559141
Post-anoxic myoclonus 18.78 11.58 6 129514 18 31567806
IVth nerve disorder 18.78 11.58 6 129514 18 31567806
Movement disorder 18.77 11.58 92 129428 10927 31556897
Energy increased 18.77 11.58 24 129496 1192 31566632
Diabetic coma 18.72 11.58 20 129500 818 31567006
Schizoaffective disorder bipolar type 18.72 11.58 8 129512 64 31567760
Gastric disorder 18.70 11.58 12 129508 11516 31556308
Neutropenic sepsis 18.60 11.58 14 129506 12365 31555459
Kyphosis 18.60 11.58 23 129497 1104 31566720
Mucosal ulceration 18.55 11.58 21 129499 917 31566907
Iris coloboma 18.54 11.58 6 129514 19 31567805
Sarcopenia 18.54 11.58 14 129506 360 31567464
Skin exfoliation 18.53 11.58 44 129476 23830 31543994
Gingival hypertrophy 18.51 11.58 29 129491 1741 31566083
Circadian rhythm sleep disorder 18.50 11.58 15 129505 429 31567395
Tendonitis 18.40 11.58 6 129514 8552 31559272
Dermatitis 18.39 11.58 6 129514 8550 31559274
Metastases to liver 18.36 11.58 15 129505 12712 31555112
Suspiciousness 18.28 11.58 13 129507 304 31567520
Jaundice 18.24 11.58 63 129457 30224 31537600
Sperm concentration decreased 18.23 11.58 10 129510 145 31567679
Poor sucking reflex 18.20 11.58 13 129507 306 31567518
Ammonia abnormal 18.20 11.58 8 129512 69 31567755
Rebound effect 18.19 11.58 35 129485 2478 31565346
Psychomotor disadaptation syndrome 18.17 11.58 5 129515 7 31567817
Intermittent explosive disorder 18.17 11.58 5 129515 7 31567817
Pulmonary oedema 18.12 11.58 107 129413 44395 31523429
Laryngeal web 18.02 11.58 4 129516 0 31567824
Mentally late developer 18.02 11.58 4 129516 0 31567824
Ear, nose and throat examination abnormal 18.02 11.58 4 129516 0 31567824
Retracted nipple 18.02 11.58 4 129516 0 31567824
Dentofacial anomaly 18.02 11.58 4 129516 0 31567824
Coma blister 17.91 11.58 8 129512 72 31567752
Gastric ulcer 17.90 11.58 20 129500 14614 31553210
Carnitine deficiency 17.90 11.58 9 129511 108 31567716
Automatism 17.82 11.58 9 129511 109 31567715
Cardiac failure chronic 17.81 11.58 4 129516 7299 31560525
Product administration error 17.80 11.58 115 129405 15132 31552692
Aspiration 17.80 11.58 89 129431 10657 31557167
Agranulocytosis 17.78 11.58 148 129372 21099 31546725
Aura 17.74 11.58 13 129507 319 31567505
Congenital inguinal hernia 17.70 11.58 10 129510 154 31567670
Adenoidectomy 17.68 11.58 9 129511 111 31567713
Type 1 diabetes mellitus 17.65 11.58 45 129475 3855 31563969
Hyperhomocysteinaemia 17.63 11.58 11 129509 205 31567619
Postural tremor 17.63 11.58 13 129507 322 31567502
Body dysmorphic disorder 17.61 11.58 9 129511 112 31567712
Compensatory sweating 17.47 11.58 6 129514 24 31567800
Conjunctival hyperaemia 17.46 11.58 32 129488 2184 31565640
Injection site erythema 17.43 11.58 20 129500 14442 31553382
Hypomagnesaemia 17.42 11.58 32 129488 19026 31548798
Phimosis 17.38 11.58 18 129502 710 31567114
Oral candidiasis 17.34 11.58 12 129508 11065 31556759
Hyporeflexia 17.32 11.58 29 129491 1841 31565983
Simple partial seizures 17.27 11.58 12 129508 270 31567554
Tachyphrenia 17.20 11.58 23 129497 1194 31566630
Throat tightness 17.16 11.58 5 129515 7664 31560160
Immune reconstitution inflammatory syndrome 17.12 11.58 6 129514 8172 31559652
Neurological decompensation 17.10 11.58 35 129485 2592 31565232
Hyperthyroidism 17.08 11.58 9 129511 9622 31558202
Colitis ulcerative 17.04 11.58 31 129489 18498 31549326
Conversion disorder 16.99 11.58 13 129507 341 31567483
Heart rate irregular 16.97 11.58 20 129500 14269 31553555
Thought blocking 16.94 11.58 9 129511 122 31567702
School refusal 16.91 11.58 6 129514 27 31567797
Pancreatic carcinoma 16.85 11.58 7 129513 8593 31559231
Mydriasis 16.84 11.58 62 129458 6490 31561334
Excessive masturbation 16.76 11.58 8 129512 85 31567739
Ankyloglossia congenital 16.71 11.58 12 129508 285 31567539
Craniofacial deformity 16.68 11.58 8 129512 86 31567738
Anxiety disorder 16.66 11.58 27 129493 1668 31566156
Wrist deformity 16.64 11.58 13 129507 352 31567472
Maternal drugs affecting foetus 16.60 11.58 44 129476 3859 31563965
Wheezing 16.59 11.58 83 129437 35903 31531921
Coronary artery occlusion 16.50 11.58 11 129509 10345 31557479
Hepatic cirrhosis 16.50 11.58 24 129496 15650 31552174
Syndactyly 16.49 11.58 19 129501 846 31566978
Injection site reaction 16.48 11.58 14 129506 11637 31556187
Chromaturia 16.46 11.58 18 129502 13280 31554544
Muscle twitching 16.45 11.58 72 129448 8158 31559666
Kidney malformation 16.43 11.58 10 129510 178 31567646
Peripheral sensory neuropathy 16.35 11.58 3 129517 6312 31561512
Hypokinesia 16.33 11.58 71 129449 8021 31559803
Gastrointestinal adenocarcinoma 16.27 11.58 7 129513 57 31567767
Metastases to lung 16.27 11.58 7 129513 8415 31559409
Neutrophil Pelger-Huet anomaly present 16.25 11.58 11 129509 237 31567587
Dementia with Lewy bodies 16.24 11.58 17 129503 679 31567145
Incoherent 16.22 11.58 46 129474 4198 31563626
Product administered to patient of inappropriate age 16.22 11.58 36 129484 2821 31565003
Polydipsia 16.18 11.58 41 129479 3499 31564325
Myocardial ischaemia 16.13 11.58 27 129493 16640 31551184
Nephrogenic diabetes insipidus 16.02 11.58 22 129498 1172 31566652
Cardiac failure acute 15.99 11.58 10 129510 9731 31558093
Irregular sleep phase 15.96 11.58 7 129513 60 31567764
Congenital cerebral cyst 15.90 11.58 5 129515 14 31567810
Epileptic aura 15.90 11.58 5 129515 14 31567810
Therapy interrupted 15.90 11.58 12 129508 10584 31557240
Cytopenia 15.85 11.58 13 129507 10997 31556827
Separation anxiety disorder 15.79 11.58 4 129516 3 31567821
Congenital jaw malformation 15.79 11.58 4 129516 3 31567821
Hyperglycinaemia 15.79 11.58 4 129516 3 31567821
Poisoning 15.78 11.58 84 129436 10307 31557517
Pancreatitis haemorrhagic 15.78 11.58 12 129508 312 31567512
Embolism 15.74 11.58 5 129515 7248 31560576
Lordosis 15.74 11.58 11 129509 250 31567574
Eating disorder 15.73 11.58 67 129453 7502 31560322
Contraindicated product administered 15.70 11.58 36 129484 19736 31548088
Miosis 15.65 11.58 73 129447 8497 31559327
Diarrhoea haemorrhagic 15.60 11.58 3 129517 6103 31561721
Delayed fontanelle closure 15.50 11.58 6 129514 36 31567788
Hyperreflexia 15.45 11.58 36 129484 2913 31564911
Toxic epidermal necrolysis 15.28 11.58 134 129386 19390 31548434
Enteritis 15.22 11.58 5 129515 7094 31560730
Auditory disorder 15.22 11.58 11 129509 264 31567560
Abnormal labour affecting foetus 15.18 11.58 5 129515 17 31567807
Epileptic psychosis 15.18 11.58 5 129515 17 31567807
Hypercalcaemia 15.17 11.58 21 129499 13979 31553845
Acute pulmonary oedema 15.14 11.58 5 129515 7071 31560753
Bronchiectasis 15.13 11.58 6 129514 7574 31560250
Abnormal palmar/plantar creases 15.12 11.58 10 129510 207 31567617
Mixed delusion 15.10 11.58 6 129514 39 31567785
Erectile dysfunction 15.05 11.58 132 129388 19103 31548721
Opsoclonus myoclonus 15.03 11.58 7 129513 70 31567754
Illusion 14.97 11.58 17 129503 745 31567079
Reproductive tract hypoplasia, male 14.97 11.58 5 129515 18 31567806
Camptocormia 14.90 11.58 9 129511 158 31567666
Nephrotic syndrome 14.90 11.58 5 129515 6998 31560826
Muscle contracture 14.86 11.58 21 129499 1149 31566675
Rebound psychosis 14.85 11.58 9 129511 159 31567665
Appendicitis 14.77 11.58 15 129505 11450 31556374
Polydipsia psychogenic 14.64 11.58 8 129512 115 31567709
Intestinal perforation 14.64 11.58 8 129512 8381 31559443
Oral mucosa erosion 14.64 11.58 18 129502 859 31566965
Fungal infection 14.62 11.58 23 129497 14528 31553296
Blood urine present 14.62 11.58 12 129508 10145 31557679
Anamnestic reaction 14.60 11.58 6 129514 43 31567781
Feminisation acquired 14.60 11.58 6 129514 43 31567781
Hypovolaemia 14.59 11.58 8 129512 8364 31559460
Hyperdynamic left ventricle 14.51 11.58 9 129511 166 31567658
Pulmonary thrombosis 14.50 11.58 5 129515 6880 31560944
Poor quality sleep 14.46 11.58 66 129454 7612 31560212
Nocturia 14.46 11.58 10 129510 9225 31558599
Hepatitis B 14.43 11.58 3 129517 5778 31562046
Gender dysphoria 14.37 11.58 6 129514 45 31567779
Urosepsis 14.35 11.58 16 129504 11704 31556120
Sinus disorder 14.28 11.58 4 129516 6291 31561533
Myopathy 14.21 11.58 14 129506 10838 31556986
Wrong technique in product usage process 14.20 11.58 79 129441 33264 31534560
Suspected suicide attempt 14.17 11.58 8 129512 123 31567701
Otitis media acute 14.16 11.58 14 129506 522 31567302
Cardiac murmur 14.16 11.58 60 129460 6702 31561122
Gingival atrophy 14.15 11.58 6 129514 47 31567777
Inappropriate schedule of product administration 14.12 11.58 136 129384 50687 31517137
Haematoma 14.00 11.58 51 129469 24088 31543736
Cytomegalovirus viraemia 13.96 11.58 5 129515 6720 31561104
Injection site pruritus 13.93 11.58 4 129516 6190 31561634
Drug ineffective for unapproved indication 13.87 11.58 122 129398 17668 31550156
Vasoplegia syndrome 13.83 11.58 25 129495 1688 31566136
Screaming 13.82 11.58 22 129498 1339 31566485
Small intestinal obstruction 13.82 11.58 21 129499 13451 31554373
Accidental death 13.80 11.58 29 129491 2188 31565636
Mouth breathing 13.77 11.58 7 129513 86 31567738
Gastritis 13.77 11.58 40 129480 20252 31547572
Seasonal allergy 13.75 11.58 3 129517 5585 31562239
Skin disorder 13.73 11.58 18 129502 12263 31555561
Tympanic membrane disorder 13.73 11.58 6 129514 51 31567773
Use of accessory respiratory muscles 13.72 11.58 12 129508 382 31567442
Frontotemporal dementia 13.69 11.58 10 129510 244 31567580
Coprolalia 13.67 11.58 5 129515 25 31567799
Lacrimal gland enlargement 13.67 11.58 5 129515 25 31567799
Ventricular fibrillation 13.65 11.58 36 129484 18812 31549012
Migraine 13.63 11.58 102 129418 14078 31553746
Anuria 13.63 11.58 12 129508 9802 31558022
Dysphemia 13.61 11.58 23 129497 1471 31566353
Skin lesion 13.61 11.58 38 129482 19489 31548335
Reduced facial expression 13.57 11.58 17 129503 827 31566997
Limb asymmetry 13.56 11.58 7 129513 89 31567735
Device issue 13.53 11.58 9 129511 8475 31559349
Compulsive shopping 13.53 11.58 12 129508 389 31567435
Niemann-Pick disease 13.53 11.58 6 129514 53 31567771
Dacryoadenitis acquired 13.51 11.58 3 129517 0 31567824
Deformity of orbit 13.51 11.58 3 129517 0 31567824
Blindness congenital 13.51 11.58 3 129517 0 31567824
Neonatal hypoacusis 13.51 11.58 3 129517 0 31567824
Acquired epileptic aphasia 13.51 11.58 3 129517 0 31567824
Renal fusion anomaly 13.51 11.58 3 129517 0 31567824
Congenital tongue anomaly 13.51 11.58 3 129517 0 31567824
Hypocarnitinaemia 13.51 11.58 3 129517 0 31567824
Therapeutic response changed 13.51 11.58 12 129508 390 31567434
Haemorrhagic stroke 13.51 11.58 4 129516 6066 31561758
Adverse drug reaction 13.49 11.58 55 129465 25146 31542678
Off label use 13.47 11.58 1229 128291 346045 31221779
Hip fracture 13.45 11.58 15 129505 10971 31556853
Gastric cancer 13.42 11.58 4 129516 6041 31561783
Wound 13.41 11.58 20 129500 12908 31554916
Cholangitis 13.39 11.58 8 129512 7978 31559846
Sudden death 13.34 11.58 103 129417 14354 31553470
Echopraxia 13.34 11.58 4 129516 9 31567815
Renal cyst 13.33 11.58 9 129511 8407 31559417
Neurotoxicity 13.33 11.58 29 129491 16197 31551627
Illness 13.30 11.58 11 129509 9266 31558558
Cerebral cyst 13.21 11.58 10 129510 258 31567566
Haemorrhage intracranial 13.21 11.58 26 129494 15062 31552762
CSF white blood cell count positive 13.20 11.58 5 129515 28 31567796
Drug level fluctuating 13.17 11.58 13 129507 484 31567340
Hand-eye coordination impaired 13.15 11.58 6 129514 57 31567767
Progressive multifocal leukoencephalopathy 13.12 11.58 11 129509 9202 31558622
Agitation neonatal 13.11 11.58 19 129501 1064 31566760
Blood urea decreased 13.10 11.58 18 129502 959 31566865
Adenoidal hypertrophy 13.07 11.58 8 129512 144 31567680
Hepatocellular carcinoma 13.03 11.58 10 129510 8746 31559078
Mastication disorder 13.01 11.58 20 129500 1181 31566643
Dysphonia 12.96 11.58 42 129478 20549 31547275
Gallbladder disorder 12.94 11.58 4 129516 5901 31561923
Ischaemic cardiomyopathy 12.92 11.58 4 129516 5893 31561931
Spinal fracture 12.87 11.58 6 129514 6882 31560942
Disseminated intravascular coagulation 12.85 11.58 42 129478 20495 31547329
Drug withdrawal syndrome 12.81 11.58 125 129395 18625 31549199
Mass 12.78 11.58 7 129513 7324 31560500
SJS-TEN overlap 12.76 11.58 10 129510 272 31567552
Heparin-induced thrombocytopenia 12.75 11.58 3 129517 5303 31562521
Multiple organ dysfunction syndrome 12.69 11.58 199 129321 68004 31499820
Saccadic eye movement 12.69 11.58 8 129512 152 31567672
Electrocardiogram QT prolonged 12.68 11.58 222 129298 37765 31530059
Dysphagia 12.68 11.58 317 129203 57359 31510465
Base excess increased 12.65 11.58 5 129515 32 31567792
Colon cancer 12.61 11.58 10 129510 8603 31559221
Pulmonary eosinophilia 12.60 11.58 9 129511 212 31567612
Oxygen saturation decreased 12.58 11.58 134 129386 48981 31518843
Lung neoplasm malignant 12.53 11.58 30 129490 16200 31551624
Locomotive syndrome 12.52 11.58 4 129516 12 31567812
Monorchidism 12.52 11.58 4 129516 12 31567812
Bulimia nervosa 12.52 11.58 5 129515 33 31567791
Pulmonary valve incompetence 12.51 11.58 16 129504 795 31567029
Blood osmolarity increased 12.50 11.58 11 129509 353 31567471
Blood alkaline phosphatase increased 12.43 11.58 70 129450 29383 31538441
Stress 12.39 11.58 56 129464 24885 31542939
Cardiovascular disorder 12.39 11.58 12 129508 9366 31558458
Subacute sclerosing panencephalitis 12.39 11.58 5 129515 34 31567790
Clonus 12.39 11.58 30 129490 2489 31565335
Terminal insomnia 12.33 11.58 12 129508 439 31567385
Haematotoxicity 12.18 11.58 7 129513 7130 31560694
Anticoagulation drug level decreased 12.16 11.58 7 129513 112 31567712
Joint range of motion decreased 12.15 11.58 6 129514 6655 31561169
Burning sensation 12.11 11.58 32 129488 16715 31551109
Feeding disorder 12.11 11.58 55 129465 6331 31561493
Feeling of despair 12.10 11.58 17 129503 925 31566899
Hypotony maculopathy 12.06 11.58 4 129516 14 31567810
Snoring 12.06 11.58 33 129487 2950 31564874
Cytotoxic oedema 11.99 11.58 8 129512 168 31567656
Necrotising enterocolitis neonatal 11.97 11.58 9 129511 230 31567594
Maternal exposure during pregnancy 11.92 11.58 44 129476 4612 31563212
Back disorder 11.87 11.58 5 129515 6088 31561736
Ischaemic stroke 11.85 11.58 33 129487 16938 31550886
Gastrointestinal disorder 11.81 11.58 75 129445 30585 31537239
Dysuria 11.80 11.58 55 129465 24239 31543585
Bronchospasm 11.79 11.58 14 129506 9958 31557866
Wrong schedule 11.79 11.58 8 129512 173 31567651
Mitochondrial cytopathy 11.79 11.58 8 129512 173 31567651
Anodontia 11.79 11.58 6 129514 74 31567750
Adenocarcinoma of appendix 11.78 11.58 7 129513 119 31567705
Laryngitis 11.75 11.58 27 129493 2165 31565659
Macrocephaly 11.70 11.58 12 129508 468 31567356
Anticholinergic syndrome 11.62 11.58 18 129502 1070 31566754
Organising pneumonia 11.61 11.58 4 129516 5506 31562318
Infertility male 11.59 11.58 8 129512 178 31567646
Prostate cancer metastatic 11.58 11.58 5 129515 5999 31561825

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 3050.15 10.66 3038 189363 174924 70561119
Hyperammonaemia 2335.90 10.66 923 191478 9370 70726673
Drug interaction 2169.28 10.66 3778 188623 377663 70358380
Epilepsy 1868.46 10.66 1216 191185 37568 70698475
Hyperammonaemic encephalopathy 1867.71 10.66 628 191773 3815 70732228
Status epilepticus 1636.45 10.66 947 191454 23579 70712464
Aggression 1236.64 10.66 1036 191365 47410 70688633
Neuroleptic malignant syndrome 1135.03 10.66 767 191634 25240 70710803
Somnolence 1111.64 10.66 2050 190351 213556 70522487
Sopor 938.07 10.66 735 191666 30532 70705511
Generalised tonic-clonic seizure 858.46 10.66 789 191612 40872 70695171
Psychotic disorder 763.16 10.66 707 191694 36994 70699049
Extrapyramidal disorder 756.06 10.66 548 191853 20202 70715841
Mania 750.45 10.66 507 191894 16667 70719376
Rheumatoid arthritis 718.64 10.66 15 192386 291790 70444253
Ammonia increased 703.10 10.66 357 192044 6781 70729262
Granulocytopenia 696.38 10.66 406 191995 10241 70725802
Arthralgia 680.79 10.66 258 192143 503132 70232911
Toxicity to various agents 673.23 10.66 2420 189981 379752 70356291
Intentional overdose 652.20 10.66 1047 191354 97388 70638655
Agitation 651.52 10.66 1017 191384 92358 70643685
Parkinsonism 625.98 10.66 434 191967 14891 70721152
Coma 623.71 10.66 988 191413 90856 70645187
Multiple-drug resistance 604.91 10.66 326 192075 7029 70729014
Overdose 590.79 10.66 1374 191027 168371 70567672
Petit mal epilepsy 576.54 10.66 286 192115 5158 70730885
Pain 566.93 10.66 524 191877 628292 70107751
Dyspnoea 566.11 10.66 759 191642 769301 69966742
Intentional self-injury 550.49 10.66 546 191855 31104 70704939
Abnormal behaviour 529.65 10.66 558 191843 34151 70701892
Sedation 485.24 10.66 616 191785 46115 70689928
Drug level increased 469.14 10.66 536 191865 35933 70700110
Tremor 463.83 10.66 1187 191214 154437 70581606
Ataxia 459.36 10.66 430 191971 22787 70713256
Joint swelling 453.45 10.66 72 192329 253139 70482904
Diarrhoea 447.91 10.66 909 191492 782432 69953611
Depressed level of consciousness 431.57 10.66 817 191584 86614 70649429
Salivary hypersecretion 425.09 10.66 321 192080 12604 70723439
Suicide attempt 413.69 10.66 760 191641 78750 70657293
Drug abuse 407.91 10.66 1093 191308 146163 70589880
Drug reaction with eosinophilia and systemic symptoms 388.03 10.66 620 191781 57393 70678650
Fatigue 386.20 10.66 1063 191338 823256 69912787
Irritability 381.29 10.66 494 191907 37731 70698312
Infusion related reaction 375.07 10.66 47 192354 197487 70538556
Anticonvulsant drug level increased 359.81 10.66 162 192239 2324 70733719
Cognitive disorder 356.09 10.66 613 191788 60343 70675700
Antipsychotic drug level increased 341.40 10.66 202 192199 5238 70730805
Peripheral swelling 336.68 10.66 111 192290 236452 70499591
Synovitis 333.58 10.66 3 192398 129225 70606818
Partial seizures 331.86 10.66 231 192170 7974 70728069
Encephalopathy 331.61 10.66 598 191803 61063 70674980
Foetal anticonvulsant syndrome 329.43 10.66 85 192316 156 70735887
Altered state of consciousness 326.17 10.66 469 191932 39553 70696490
Nausea 325.36 10.66 1204 191197 850884 69885159
Delusion 324.69 10.66 326 192075 18839 70717204
Catatonia 322.00 10.66 226 192175 7907 70728136
Blood creatine phosphokinase increased 321.67 10.66 588 191813 60675 70675368
Arthropathy 318.34 10.66 23 192378 150034 70586009
Fanconi syndrome 315.66 10.66 152 192249 2561 70733482
Drug level decreased 311.63 10.66 265 192136 12359 70723684
Psychomotor hyperactivity 309.44 10.66 288 192113 15145 70720898
Schizophrenia 307.81 10.66 298 192103 16470 70719573
Pain in extremity 304.94 10.66 265 192136 327817 70408226
Hallucination, auditory 301.79 10.66 307 192094 18021 70718022
Myoclonic epilepsy 300.45 10.66 131 192270 1733 70734310
Bipolar disorder 290.99 10.66 207 192194 7401 70728642
Electroencephalogram abnormal 290.69 10.66 180 192221 5078 70730965
Hypernatraemia 279.03 10.66 250 192151 12511 70723532
Anticonvulsant drug level decreased 277.66 10.66 124 192277 1743 70734300
Febrile neutropenia 275.08 10.66 105 192296 204213 70531830
Muscle rigidity 274.13 10.66 294 192107 18356 70717687
Treatment noncompliance 272.81 10.66 469 191932 46105 70689938
Anticonvulsant drug level above therapeutic 258.50 10.66 102 192299 1029 70735014
Sinusitis 257.72 10.66 70 192331 169125 70566918
Delirium 257.01 10.66 602 191799 74012 70662031
Swelling 256.97 10.66 95 192306 188444 70547599
Dysmorphism 252.36 10.66 83 192318 465 70735578
Disorientation 251.46 10.66 513 191888 57410 70678633
Tardive dyskinesia 250.36 10.66 211 192190 9718 70726325
Pneumonia aspiration 249.79 10.66 534 191867 61755 70674288
Sudden unexplained death in epilepsy 245.18 10.66 85 192316 573 70735470
Suicidal ideation 243.51 10.66 565 191836 69031 70667012
Abdominal discomfort 243.25 10.66 140 192261 214518 70521525
Hypothermia 240.34 10.66 288 192113 20306 70715737
Nasopharyngitis 239.14 10.66 154 192247 222052 70513991
Depression 237.48 10.66 1119 191282 197855 70538188
Completed suicide 236.04 10.66 1228 191173 225907 70510136
Hypersensitivity 231.73 10.66 171 192230 229641 70506402
Foetal exposure during pregnancy 230.81 10.66 160 192241 5485 70730558
Intellectual disability 229.05 10.66 93 192308 1017 70735026
Disturbance in attention 226.77 10.66 413 191988 42481 70693562
Myoclonus 226.77 10.66 317 192084 26038 70710005
Psychomotor skills impaired 220.10 10.66 140 192261 4144 70731899
Cough 218.09 10.66 341 192060 325036 70411007
Drug withdrawal convulsions 213.18 10.66 108 192293 2040 70734003
Bradyphrenia 211.83 10.66 192 192209 9754 70726289
Dystonia 211.21 10.66 264 192137 19442 70716601
Psychomotor retardation 204.21 10.66 148 192253 5450 70730593
Headache 201.22 10.66 851 191550 579554 70156489
Dysarthria 200.82 10.66 490 191911 61823 70674220
Akathisia 198.90 10.66 204 192197 12089 70723954
Pruritus 197.48 10.66 400 192001 345160 70390883
Myocarditis 197.01 10.66 249 192152 18544 70717499
Paranoia 193.96 10.66 237 192164 17051 70718992
Mental impairment 189.48 10.66 234 192167 17021 70719022
Anticonvulsant drug level below therapeutic 187.16 10.66 79 192322 960 70735083
Stevens-Johnson syndrome 185.10 10.66 342 192059 35565 70700478
Contraindicated product administered 184.78 10.66 67 192334 134545 70601498
Anaemia 183.83 10.66 526 191875 402897 70333146
Dyskinesia 180.89 10.66 366 192035 40708 70695335
Drug ineffective 178.51 10.66 3553 188848 936199 69799844
Cardiac failure congestive 178.32 10.66 72 192329 135385 70600658
Back pain 177.08 10.66 289 192112 270863 70465180
Drug intolerance 176.86 10.66 211 192190 225476 70510567
Hepatic function abnormal 175.40 10.66 492 191909 67504 70668539
Speech disorder 175.13 10.66 409 191992 50171 70685872
Focal dyscognitive seizures 173.89 10.66 111 192290 3306 70732737
Schizoaffective disorder 172.88 10.66 92 192309 1931 70734112
Mental disorder 172.78 10.66 290 192111 27950 70708093
Drug resistance 172.60 10.66 344 192057 37846 70698197
Systemic lupus erythematosus 171.32 10.66 34 192367 101868 70634175
Chest pain 170.50 10.66 261 192140 250999 70485044
Confusional state 168.31 10.66 1333 191068 283065 70452978
Psychogenic seizure 167.05 10.66 88 192313 1808 70734235
Hypomania 165.50 10.66 135 192266 5937 70730106
Restlessness 164.09 10.66 357 192044 41771 70694272
Drug ineffective for unapproved indication 163.32 10.66 338 192063 38200 70697843
Neuropathy peripheral 162.92 10.66 70 192331 126826 70609217
Plasma cell myeloma 158.77 10.66 10 192391 73191 70662852
Glossodynia 158.31 10.66 23 192378 86464 70649579
Atrial fibrillation 156.90 10.66 161 192240 184187 70551856
Arthritis 155.96 10.66 37 192364 97943 70638100
Paradoxical drug reaction 155.04 10.66 135 192266 6501 70729542
Developmental delay 153.99 10.66 70 192331 1028 70735015
Stupor 153.25 10.66 133 192268 6376 70729667
Toxic encephalopathy 152.85 10.66 164 192237 10242 70725801
Nystagmus 152.72 10.66 156 192245 9199 70726844
Behaviour disorder 147.92 10.66 121 192280 5343 70730700
Abdominal pain upper 147.45 10.66 185 192216 193417 70542626
Discomfort 145.50 10.66 52 192349 105384 70630659
Speech disorder developmental 140.87 10.66 56 192345 577 70735466
Electrocardiogram QT prolonged 140.49 10.66 522 191879 82995 70653048
Gastrointestinal haemorrhage 137.45 10.66 103 192298 137305 70598738
Leukopenia 137.15 10.66 613 191788 105947 70630096
Autism spectrum disorder 136.88 10.66 64 192337 1006 70735037
Persecutory delusion 134.99 10.66 106 192295 4411 70731632
Injection site pain 134.18 10.66 76 192325 117543 70618500
Myocardial infarction 133.88 10.66 161 192240 171484 70564559
Mental status changes 133.76 10.66 426 191975 62675 70673368
Wrong patient received product 133.60 10.66 105 192296 4375 70731668
Brain oedema 132.11 10.66 232 192169 23186 70712857
Thrombocytopenia 130.20 10.66 1100 191301 238010 70498033
Eosinophilia 128.76 10.66 316 192085 40003 70696040
Tonic convulsion 127.90 10.66 76 192325 1986 70734057
Oculogyric crisis 125.89 10.66 83 192318 2615 70733428
Bipolar I disorder 125.06 10.66 73 192328 1844 70734199
Urticaria 124.98 10.66 155 192246 162894 70573149
Impaired healing 124.63 10.66 25 192376 74349 70661694
Cerebral atrophy 123.47 10.66 126 192275 7421 70728622
Rhabdomyolysis 123.32 10.66 551 191850 95209 70640834
Blood pressure increased 122.93 10.66 201 192200 188316 70547727
Priapism 121.86 10.66 96 192305 4014 70732029
Wound 121.20 10.66 58 192343 98674 70637369
Herpes zoster 121.13 10.66 40 192361 85195 70650848
Duodenal ulcer perforation 120.51 10.66 4 192397 51108 70684935
Lethargy 119.68 10.66 462 191939 74788 70661255
Malignant neoplasm progression 118.27 10.66 94 192307 121645 70614398
Psoriatic arthropathy 116.75 10.66 18 192383 64753 70671290
Abdominal pain 116.21 10.66 505 191896 341622 70394421
Osteoarthritis 116.05 10.66 29 192372 74118 70661925
Acute kidney injury 115.75 10.66 783 191618 473841 70262202
Stomatitis 115.37 10.66 107 192294 128404 70607639
Interstitial lung disease 114.67 10.66 71 192330 104614 70631429
Psoriasis 114.59 10.66 62 192339 98371 70637672
Atonic seizures 114.44 10.66 51 192350 713 70735330
Helicobacter infection 113.88 10.66 10 192391 55646 70680397
Asterixis 113.45 10.66 75 192326 2374 70733669
Learning disorder 112.81 10.66 46 192355 509 70735534
Disease progression 111.83 10.66 157 192244 156515 70579528
Dyspnoea exertional 111.11 10.66 37 192364 78393 70657650
Infantile spasms 111.04 10.66 42 192359 374 70735669
Antipsychotic drug level above therapeutic 110.03 10.66 68 192333 1911 70734132
Hypoaesthesia 109.80 10.66 154 192247 153585 70582458
Hyperprolactinaemia 107.61 10.66 92 192309 4321 70731722
Eosinophilic pleural effusion 107.54 10.66 38 192363 273 70735770
Psychiatric symptom 107.02 10.66 110 192291 6534 70729509
Pleurothotonus 106.08 10.66 71 192330 2295 70733748
Neutrophil count increased 105.40 10.66 228 192173 26567 70709476
Therapeutic product effect decreased 104.40 10.66 141 192260 142877 70593166
Affect lability 104.07 10.66 133 192268 10013 70726030
Drug level below therapeutic 103.43 10.66 123 192278 8600 70727443
Impulsive behaviour 103.17 10.66 74 192327 2680 70733363
Thrombosis 102.66 10.66 38 192363 75367 70660676
Injection site erythema 102.26 10.66 35 192366 72889 70663154
Myalgia 102.16 10.66 187 192214 167705 70568338
Antipsychotic drug level below therapeutic 102.08 10.66 51 192350 934 70735109
Chest discomfort 102.02 10.66 112 192289 124269 70611774
Influenza 101.67 10.66 95 192306 113605 70622438
Blood prolactin increased 101.34 10.66 83 192318 3671 70732372
Death 101.10 10.66 891 191510 509170 70226873
Fluid retention 100.74 10.66 24 192377 63361 70672682
Metabolic acidosis 100.43 10.66 434 191967 73912 70662131
Hypotonia 99.51 10.66 141 192260 11724 70724319
Asthenia 98.58 10.66 782 191619 456884 70279159
Psychiatric decompensation 97.79 10.66 74 192327 2913 70733130
Carnitine deficiency 97.47 10.66 34 192367 234 70735809
Acidosis hyperchloraemic 97.25 10.66 45 192356 690 70735353
Hypertonia 96.47 10.66 103 192298 6395 70729648
Pancreatitis acute 96.46 10.66 306 192095 44918 70691125
Thinking abnormal 96.36 10.66 140 192261 11911 70724132
Bradykinesia 95.99 10.66 110 192291 7392 70728651
Seizure cluster 95.95 10.66 37 192364 349 70735694
White blood cell count increased 95.41 10.66 408 191993 69165 70666878
Gaze palsy 94.47 10.66 70 192331 2668 70733375
Malaise 93.11 10.66 740 191661 432192 70303851
Alopecia 93.05 10.66 255 192146 198235 70537808
Musculoskeletal pain 92.53 10.66 66 192335 90261 70645782
Rash 91.27 10.66 915 191486 509647 70226396
Product substitution issue 91.24 10.66 173 192228 18340 70717703
Cerebellar atrophy 90.87 10.66 49 192352 1057 70734986
Loss of consciousness 89.30 10.66 725 191676 154991 70581052
Antipsychotic drug level decreased 88.91 10.66 48 192353 1038 70735005
Dysphoria 88.35 10.66 83 192318 4415 70731628
Product residue present 87.82 10.66 73 192328 3297 70732746
Drug hypersensitivity 86.89 10.66 391 192010 262068 70473975
Euphoric mood 86.44 10.66 100 192301 6789 70729254
Anger 86.09 10.66 156 192245 15976 70720067
Folliculitis 83.54 10.66 9 192392 42561 70693482
Differential white blood cell count abnormal 83.08 10.66 56 192345 1832 70734211
Mucosal inflammation 83.05 10.66 40 192361 67810 70668233
Inappropriate antidiuretic hormone secretion 81.40 10.66 189 192212 23087 70712956
Psychotic symptom 81.15 10.66 61 192340 2377 70733666
Infection 80.43 10.66 297 192104 210488 70525555
Oppositional defiant disorder 80.40 10.66 35 192366 461 70735582
Bronchitis 80.21 10.66 121 192280 117122 70618921
Poisoning 79.46 10.66 184 192217 22438 70713605
Toxic epidermal necrolysis 79.25 10.66 262 192139 39295 70696748
Drooling 78.65 10.66 85 192316 5351 70730692
COVID-19 78.46 10.66 103 192298 105654 70630389
Contusion 78.42 10.66 142 192259 127894 70608149
Muscle spasms 78.26 10.66 190 192211 153856 70582187
Coordination abnormal 77.78 10.66 149 192252 15917 70720126
Intentional product use issue 77.45 10.66 129 192272 120013 70616030
Inflammation 77.32 10.66 60 192341 78605 70657438
Pneumonia 77.12 10.66 1146 191255 595086 70140957
Cardiac failure 76.96 10.66 172 192229 143369 70592674
Respiratory depression 76.52 10.66 192 192209 24639 70711404
Chills 76.40 10.66 175 192226 144611 70591432
Epistaxis 76.09 10.66 100 192301 102527 70633516
Muscle injury 75.89 10.66 8 192393 38486 70697557
Rhinorrhoea 75.51 10.66 43 192358 66328 70669715
Haematochezia 75.38 10.66 53 192348 73028 70663015
Neutropenia 74.44 10.66 1043 191358 256113 70479930
Gait disturbance 74.04 10.66 798 191603 184308 70551735
C-reactive protein abnormal 73.59 10.66 9 192392 38570 70697473
Hyponatraemia 73.51 10.66 710 191691 159377 70576666
Knee arthroplasty 73.45 10.66 5 192396 34296 70701747
Logorrhoea 73.40 10.66 72 192329 4042 70732001
Depressive symptom 73.20 10.66 80 192321 5101 70730942
Dysmetria 73.07 10.66 40 192361 890 70735153
Communication disorder 72.59 10.66 69 192332 3725 70732318
Flushing 71.89 10.66 70 192331 82102 70653941
Injection site reaction 71.52 10.66 23 192378 49829 70686214
Hallucination 71.38 10.66 401 192000 75859 70660184
Blood lactic acid increased 71.37 10.66 117 192284 11056 70724987
Gastrointestinal disorder 70.96 10.66 110 192291 105317 70630726
Hyperkinesia 70.82 10.66 58 192343 2565 70733478
Propofol infusion syndrome 70.67 10.66 49 192352 1680 70734363
Oedema peripheral 70.66 10.66 348 192053 227743 70508300
Cogwheel rigidity 70.59 10.66 61 192340 2907 70733136
Cerebrovascular accident 70.50 10.66 180 192221 143290 70592753
Injection site pruritus 70.43 10.66 11 192390 39199 70696844
Hypertension 69.75 10.66 493 191908 295540 70440503
Hyperlactacidaemia 69.38 10.66 77 192324 4995 70731048
Acute hepatic failure 69.15 10.66 198 192203 27474 70708569
Paraesthesia 68.92 10.66 186 192215 145351 70590692
Irritable bowel syndrome 68.58 10.66 26 192375 50824 70685219
Renal failure 68.51 10.66 272 192129 188798 70547245
Apathy 68.50 10.66 119 192282 11789 70724254
Tachycardia 68.35 10.66 694 191707 157852 70578191
Anaphylactic reaction 67.78 10.66 62 192339 74912 70661131
Hot flush 67.47 10.66 25 192376 49559 70686484
Injection site swelling 67.29 10.66 17 192384 43140 70692903
General physical health deterioration 67.00 10.66 371 192030 235660 70500383
Pulmonary arterial hypertension 66.95 10.66 6 192395 32849 70703194
Hallucination, visual 66.72 10.66 203 192198 29134 70706909
Homicidal ideation 66.58 10.66 62 192339 3261 70732782
Attention deficit hyperactivity disorder 66.25 10.66 59 192342 2928 70733115
Carnitine decreased 66.07 10.66 14 192387 3 70736040
Tonic clonic movements 65.88 10.66 50 192351 1977 70734066
Delusion of grandeur 65.76 10.66 37 192364 870 70735173
Retinogram abnormal 65.64 10.66 27 192374 306 70735737
Unresponsive to stimuli 65.47 10.66 297 192104 51634 70684409
Erythema 65.00 10.66 299 192102 199264 70536779
Resting tremor 64.43 10.66 43 192358 1383 70734660
Affective disorder 64.38 10.66 90 192311 7389 70728654
Gingival hypertrophy 63.79 10.66 57 192344 2841 70733202
Pancreatitis 63.68 10.66 337 192064 62331 70673712
Hyperthermia 63.45 10.66 140 192261 16531 70719512
Depressed mood 63.20 10.66 261 192140 43559 70692484
Urinary incontinence 63.17 10.66 236 192165 37606 70698437
Grandiosity 62.98 10.66 31 192370 549 70735494
Mitochondrial DNA mutation 62.97 10.66 27 192374 342 70735701
Decreased eye contact 62.82 10.66 35 192366 807 70735236
Prostate cancer 62.68 10.66 6 192395 31157 70704886
Chorea 62.60 10.66 49 192352 2029 70734014
Necrosis ischaemic 62.26 10.66 37 192364 967 70735076
Serotonin syndrome 61.66 10.66 252 192149 41862 70694181
Partial seizures with secondary generalisation 61.26 10.66 31 192370 584 70735459
Pressure of speech 61.22 10.66 37 192364 998 70735045
Mood altered 61.18 10.66 137 192264 16338 70719705
Blood pressure systolic increased 61.09 10.66 40 192361 57219 70678824
Bone pain 60.63 10.66 31 192370 50791 70685252
Acute myocardial infarction 60.45 10.66 65 192336 72822 70663221
Urinary tract infection 60.20 10.66 411 191990 248358 70487685
Autonomic nervous system imbalance 59.57 10.66 66 192335 4273 70731770
Enuresis 59.56 10.66 55 192346 2862 70733181
Neoplasm progression 59.55 10.66 24 192377 45204 70690839
Posture abnormal 58.76 10.66 60 192341 3536 70732507
Nasal congestion 58.54 10.66 55 192346 65617 70670426
Disinhibition 58.21 10.66 49 192352 2252 70733791
Encephalitis autoimmune 57.84 10.66 48 192353 2163 70733880
Night sweats 57.82 10.66 23 192378 43661 70692382
Coronary artery disease 57.76 10.66 51 192350 62685 70673358
Obsessive-compulsive disorder 57.63 10.66 72 192329 5298 70730745
Drug level changed 57.61 10.66 29 192372 540 70735503
Choreoathetosis 57.40 10.66 41 192360 1475 70734568
Product dose omission issue 57.35 10.66 350 192051 217118 70518925
Dry skin 57.10 10.66 41 192360 55890 70680153
Throat irritation 56.82 10.66 13 192388 35291 70700752
Metabolic encephalopathy 56.73 10.66 90 192311 8273 70727770
Pericarditis 56.41 10.66 89 192312 84616 70651427
Ascites 56.29 10.66 60 192341 67487 70668556
Oropharyngeal pain 56.16 10.66 110 192291 96200 70639843
Craniosynostosis 56.14 10.66 17 192384 69 70735974
Mobility decreased 55.55 10.66 123 192278 102876 70633167
Learning disability 55.42 10.66 21 192380 188 70735855
Mydriasis 55.21 10.66 130 192271 16023 70720020
Heart rate decreased 55.21 10.66 52 192349 61963 70674080
Hypospadias 54.94 10.66 19 192382 127 70735916
Fibromyalgia 54.48 10.66 31 192370 47843 70688200
Congenital hand malformation 54.04 10.66 11 192390 0 70736043
Hyperosmolar state 53.85 10.66 29 192372 624 70735419
Hyperkalaemia 53.70 10.66 132 192269 106459 70629584
Intestinal ischaemia 53.69 10.66 108 192293 11956 70724087
Drop attacks 53.58 10.66 34 192367 1002 70735041
Cytokine release syndrome 53.48 10.66 5 192396 26462 70709581
Haemoptysis 53.47 10.66 37 192364 51415 70684628
Pneumonitis 53.20 10.66 42 192359 54555 70681488
Blood pressure fluctuation 53.10 10.66 49 192352 58963 70677080
Hallucinations, mixed 52.46 10.66 75 192326 6287 70729756
Pain in jaw 52.45 10.66 25 192376 42644 70693399
Dysgeusia 52.25 10.66 35 192366 49467 70686576
Hypokinesia 51.85 10.66 133 192268 17299 70718744
Physical assault 51.76 10.66 39 192362 1525 70734518
Sexually inappropriate behaviour 51.42 10.66 26 192375 489 70735554
Weight decreased 51.07 10.66 567 191834 309921 70426122
Gastrooesophageal reflux disease 51.04 10.66 106 192295 90733 70645310
Obesity 50.69 10.66 174 192227 26597 70709446
Conjunctival hyperaemia 50.66 10.66 59 192342 4034 70732009
Drug withdrawal syndrome 50.48 10.66 199 192202 32516 70703527
Osteonecrosis of jaw 50.44 10.66 24 192377 40978 70695065
Injection site bruising 50.37 10.66 20 192381 38012 70698031
Prescribed overdose 50.02 10.66 175 192226 27006 70709037
Ill-defined disorder 49.80 10.66 45 192356 54696 70681347
Postictal state 49.74 10.66 39 192362 1619 70734424
Musculoskeletal stiffness 49.53 10.66 219 192182 147541 70588502
Language disorder 49.47 10.66 50 192351 2911 70733132
Basal cell carcinoma 49.32 10.66 15 192386 33683 70702360
Diabetes insipidus 49.12 10.66 62 192339 4609 70731434
Diverticulitis 48.98 10.66 26 192375 41708 70694335
Dehydration 48.76 10.66 386 192015 225756 70510287
Lung disorder 48.20 10.66 71 192330 69413 70666630
Neovascularisation 48.09 10.66 33 192368 1112 70734931
Nephrogenic diabetes insipidus 48.02 10.66 41 192360 1922 70734121
Feeling hot 47.98 10.66 37 192364 48633 70687410
Rectal haemorrhage 47.92 10.66 65 192336 65766 70670277
Sluggishness 47.45 10.66 69 192332 5874 70730169
Lower respiratory tract infection 47.19 10.66 151 192250 111762 70624281
Leukocytosis 47.14 10.66 223 192178 39445 70696598
Cataract 46.84 10.66 49 192352 55596 70680447
Pneumocystis jirovecii pneumonia 46.61 10.66 12 192389 30070 70705973
Hyperglycinaemia 46.51 10.66 10 192391 3 70736040
Staring 45.73 10.66 44 192357 2412 70733631
Wheezing 45.59 10.66 119 192282 94051 70641992
Negativism 45.59 10.66 28 192373 778 70735265
Intra-abdominal pressure increased 45.22 10.66 19 192382 228 70735815
Joint range of motion decreased 45.19 10.66 8 192393 26018 70710025
Pulmonary hypertension 45.09 10.66 36 192365 46500 70689543
Educational problem 45.09 10.66 22 192379 382 70735661
Increased appetite 44.85 10.66 93 192308 10520 70725523
Angiofibroma 44.69 10.66 16 192385 120 70735923
Upper gastrointestinal haemorrhage 44.50 10.66 23 192378 37454 70698589
Miosis 44.46 10.66 110 192291 13991 70722052
Automatism 44.12 10.66 17 192384 160 70735883
Refusal of treatment by patient 44.05 10.66 81 192320 8389 70727654
Agranulocytosis 43.92 10.66 221 192180 40077 70695966
Pulmonary fibrosis 43.90 10.66 19 192382 34291 70701752
Oral mucosa erosion 43.45 10.66 37 192364 1728 70734315
Palmar-plantar erythrodysaesthesia syndrome 43.31 10.66 14 192387 30233 70705810
Bruxism 43.25 10.66 52 192349 3677 70732366
Mood swings 42.96 10.66 128 192273 18158 70717885
Palpitations 42.91 10.66 155 192246 110598 70625445
Dementia 42.90 10.66 146 192255 22219 70713824
Suicidal behaviour 42.85 10.66 47 192354 3009 70733034
Homicide 42.83 10.66 31 192370 1139 70734904
Dysgraphia 42.71 10.66 51 192350 3581 70732462
Melaena 42.70 10.66 54 192347 56301 70679742
Porphyria acute 42.57 10.66 32 192369 1247 70734796
Food interaction 42.54 10.66 35 192366 1558 70734485
Postictal psychosis 42.45 10.66 16 192385 141 70735902
Asthma 42.34 10.66 176 192225 120617 70615426
Renal tubular acidosis 42.23 10.66 49 192352 3337 70732706
Aphasia 42.19 10.66 230 192171 43019 70693024
Anticonvulsant drug level abnormal 42.13 10.66 13 192388 57 70735986
Judgement impaired 42.13 10.66 30 192371 1074 70734969
Flight of ideas 42.09 10.66 26 192375 730 70735313
Hypervolaemia 42.00 10.66 28 192373 39678 70696365
Erectile dysfunction 41.92 10.66 105 192296 13457 70722586
Hip arthroplasty 41.91 10.66 12 192389 28028 70708015
Lennox-Gastaut syndrome 41.91 10.66 18 192383 229 70735814
Delusional disorder, unspecified type 41.87 10.66 26 192375 737 70735306
Brugada syndrome 41.67 10.66 30 192371 1093 70734950
Intentional product misuse 41.56 10.66 363 192038 79232 70656811
Postictal paralysis 41.53 10.66 20 192381 337 70735706
Mutism 41.47 10.66 39 192362 2077 70733966
Coma scale abnormal 41.43 10.66 77 192324 8039 70728004
Acute myeloid leukaemia 41.42 10.66 16 192385 30924 70705119
Withdrawal syndrome 41.30 10.66 155 192246 24749 70711294
Excessive eye blinking 41.19 10.66 33 192368 1414 70734629
Rash maculo-papular 40.99 10.66 256 192145 50289 70685754
Metastases to bone 40.82 10.66 6 192395 22370 70713673
Cytomegalovirus infection 40.78 10.66 29 192372 39729 70696314
Bursitis 40.64 10.66 11 192390 26662 70709381
Sepsis 40.42 10.66 446 191955 244099 70491944
Dizziness 40.32 10.66 955 191446 463186 70272857
Perseveration 40.24 10.66 20 192381 362 70735681
Gastric disorder 40.23 10.66 20 192381 33302 70702741
Change in seizure presentation 40.22 10.66 19 192382 306 70735737
Acute coronary syndrome 40.03 10.66 4 192397 20075 70715968
Cellulitis 39.97 10.66 136 192265 98792 70637251
Cystitis 39.89 10.66 41 192360 46900 70689143
Schizoaffective disorder bipolar type 39.56 10.66 16 192385 173 70735870
Pulmonary embolism 39.45 10.66 254 192147 155613 70580430
Pulmonary mass 39.17 10.66 11 192390 26022 70710021
Confabulation 39.11 10.66 21 192380 449 70735594
Head titubation 39.02 10.66 26 192375 834 70735209
Flatulence 38.96 10.66 28 192373 38153 70697890
Metastases to liver 38.82 10.66 11 192390 25867 70710176
Skin ulcer 38.75 10.66 44 192357 48101 70687942
Social avoidant behaviour 38.55 10.66 55 192346 4601 70731442
Joint stiffness 38.31 10.66 24 192377 35152 70700891
Tic 38.26 10.66 42 192359 2691 70733352
Angina pectoris 38.10 10.66 45 192356 48338 70687705
Weight increased 38.08 10.66 893 191508 241438 70494605
Bacteraemia 37.86 10.66 16 192385 29293 70706750
Breast cancer 37.78 10.66 22 192379 33527 70702516
Bronchopulmonary aspergillosis 37.47 10.66 6 192395 20996 70715047
Breast hyperplasia 37.38 10.66 14 192387 121 70735922
Convulsive threshold lowered 37.33 10.66 26 192375 898 70735145
Aspergillus infection 37.13 10.66 3 192398 17865 70718178
Localised infection 36.98 10.66 22 192379 33136 70702907
Soliloquy 36.95 10.66 22 192379 577 70735466
Hypersexuality 36.92 10.66 32 192369 1531 70734512
Incoherent 36.90 10.66 69 192332 7237 70728806
Drug level above therapeutic 36.49 10.66 71 192330 7671 70728372
Tachyphrenia 36.41 10.66 35 192366 1916 70734127
Pancreatitis necrotising 36.32 10.66 45 192356 3283 70732760
Tumour lysis syndrome 36.15 10.66 7 192394 21353 70714690
Limb discomfort 35.61 10.66 18 192383 29687 70706356
Normal pressure hydrocephalus 35.55 10.66 20 192381 470 70735573
Bladder cancer 35.54 10.66 3 192398 17239 70718804
Intensive care unit acquired weakness 35.40 10.66 33 192368 1738 70734305
Adjustment disorder with mixed anxiety and depressed mood 35.38 10.66 12 192389 75 70735968
Medication error 35.35 10.66 270 192131 56642 70679401
Cryptorchism 35.34 10.66 10 192391 30 70736013
Syncope 35.17 10.66 284 192117 165425 70570618
Maternal exposure during pregnancy 35.10 10.66 177 192224 115168 70620875
Poisoning deliberate 35.07 10.66 114 192287 16946 70719097
Fungal infection 35.04 10.66 30 192371 37437 70698606
Oedema 35.02 10.66 153 192248 103428 70632615
Metabolic syndrome 34.59 10.66 38 192363 2437 70733606
Memory impairment 34.54 10.66 394 192007 92247 70643796
Echolalia 34.51 10.66 18 192383 362 70735681
Transfusion 34.48 10.66 5 192396 18831 70717212
Verbal abuse 34.42 10.66 16 192385 248 70735795
Transaminases increased 34.38 10.66 232 192169 46786 70689257
Saccadic eye movement 34.01 10.66 14 192387 159 70735884
Tendonitis 33.94 10.66 9 192392 22113 70713930
Limbic encephalitis 33.84 10.66 23 192378 763 70735280
Akinesia 33.63 10.66 42 192359 3089 70732954
Polydipsia 33.35 10.66 59 192342 5929 70730114
Stereotypy 33.34 10.66 24 192377 874 70735169
Sinus congestion 33.27 10.66 4 192397 17369 70718674
Septic shock 33.18 10.66 174 192227 112084 70623959
Microcephaly 33.10 10.66 14 192387 171 70735872
Motor developmental delay 33.07 10.66 15 192386 219 70735824
Disorganised speech 33.03 10.66 32 192369 1769 70734274
Colitis 32.95 10.66 78 192323 63736 70672307
Neurodevelopmental disorder 32.95 10.66 10 192391 41 70736002
Platelet count decreased 32.84 10.66 672 191729 177550 70558493
Hepatic adenoma 32.73 10.66 16 192385 279 70735764
Ileus paralytic 32.70 10.66 73 192328 8688 70727355
Faeces discoloured 32.51 10.66 16 192385 26793 70709250
Monocyte count increased 32.44 10.66 75 192326 9134 70726909
Cerebellar syndrome 32.36 10.66 54 192347 5177 70730866
Borderline personality disorder 32.31 10.66 23 192378 823 70735220
Hepatic failure 32.29 10.66 267 192134 57358 70678685
Thought blocking 32.19 10.66 14 192387 184 70735859
Inappropriate affect 31.84 10.66 28 192373 1366 70734677
Anaphylactic shock 31.64 10.66 25 192376 32465 70703578
Sudden death 31.59 10.66 127 192274 20937 70715106
Upper respiratory tract infection 31.33 10.66 110 192291 79164 70656879
Brief psychotic disorder, with postpartum onset 31.33 10.66 9 192392 29 70736014
Anion gap increased 31.18 10.66 41 192360 3175 70732868
Mitochondrial cytopathy 31.14 10.66 17 192384 376 70735667
Angiomyolipoma 31.02 10.66 14 192387 202 70735841
Aura 30.92 10.66 23 192378 882 70735161
Epileptic psychosis 30.86 10.66 10 192391 53 70735990
Neoplasm malignant 30.83 10.66 20 192381 28754 70707289
Hyperchloraemia 30.78 10.66 24 192377 988 70735055
Device expulsion 30.63 10.66 11 192390 22235 70713808
Constipation 30.54 10.66 491 191910 251947 70484096
Glycosuria 30.22 10.66 33 192368 2102 70733941
Renal fusion anomaly 30.07 10.66 7 192394 6 70736037
Poverty of speech 29.94 10.66 19 192382 560 70735483
Rabbit syndrome 29.93 10.66 16 192385 339 70735704
Sneezing 29.89 10.66 5 192396 16946 70719097
Screaming 29.85 10.66 43 192358 3629 70732414
Medication overuse headache 29.83 10.66 21 192380 738 70735305
Epidermolysis bullosa 29.78 10.66 14 192387 223 70735820
Product use in unapproved indication 29.71 10.66 755 191646 206723 70529320
Kidney infection 29.69 10.66 8 192393 19447 70716596
Clostridium difficile infection 29.61 10.66 37 192364 38779 70697264
Choking 29.46 10.66 81 192320 10979 70725064
Psychotic behaviour 29.37 10.66 24 192377 1058 70734985
Faecaloma 29.30 10.66 78 192323 10373 70725670
Oropharyngeal oedema 29.11 10.66 16 192385 359 70735684
Right ventricular failure 29.03 10.66 12 192389 22262 70713781
Fanconi syndrome acquired 28.92 10.66 35 192366 2492 70733551
Ulcer 28.84 10.66 17 192384 25737 70710306
Suspiciousness 28.81 10.66 19 192382 599 70735444
Accidental overdose 28.55 10.66 178 192223 34943 70701100
Febrile convulsion 28.53 10.66 22 192379 891 70735152
Ovarian granulosa-theca cell tumour 28.53 10.66 8 192393 23 70736020
Eosinophil count decreased 28.50 10.66 37 192364 2829 70733214
Subileus 28.47 10.66 51 192350 5176 70730867
Distractibility 28.36 10.66 20 192381 705 70735338
Red blood cell sedimentation rate increased 28.28 10.66 38 192363 38604 70697439
Pneumatosis 28.24 10.66 21 192380 805 70735238
Haemorrhage 28.21 10.66 124 192277 83691 70652352
Oligoasthenozoospermia 28.20 10.66 7 192394 10 70736033
Respiratory acidosis 28.09 10.66 76 192325 10205 70725838
Cardiac disorder 28.06 10.66 76 192325 59339 70676704
Lymphocyte count increased 27.99 10.66 51 192350 5245 70730798
Neurological decompensation 27.97 10.66 48 192353 4708 70731335
Hereditary ataxia 27.57 10.66 8 192393 27 70736016
Dyspepsia 27.49 10.66 136 192265 88941 70647102
Blood triglycerides increased 27.47 10.66 116 192285 19548 70716495
Blood osmolarity increased 27.39 10.66 18 192383 564 70735479
Hypertelorism 27.36 10.66 11 192390 117 70735926
Hirsutism 27.25 10.66 23 192378 1061 70734982
Apraxia 27.25 10.66 35 192366 2648 70733395
Presyncope 27.21 10.66 37 192364 37401 70698642
Neutrophil Pelger-Huet anomaly present 27.11 10.66 15 192386 341 70735702
Developmental coordination disorder 27.05 10.66 6 192395 3 70736040
Simple partial seizures 26.96 10.66 19 192382 669 70735374
Injection site warmth 26.93 10.66 3 192398 13822 70722221
Surgery 26.86 10.66 25 192376 29964 70706079
Sinus disorder 26.75 10.66 9 192392 18950 70717093
Incontinence 26.73 10.66 87 192314 12941 70723102
Device issue 26.71 10.66 16 192385 24009 70712034
Rash pruritic 26.54 10.66 85 192316 62906 70673137
Renal impairment 26.43 10.66 256 192145 143681 70592362
Blood pressure diastolic abnormal 26.41 10.66 5 192396 15499 70720544
Heart rate irregular 26.40 10.66 25 192376 29718 70706325
Device related infection 26.35 10.66 29 192372 32156 70703887
Failure to suspend medication 26.33 10.66 16 192385 436 70735607
Colitis ulcerative 26.23 10.66 32 192369 33891 70702152
Balance disorder 26.20 10.66 366 192035 89762 70646281
Amenorrhoea 26.15 10.66 58 192343 6872 70729171
Systemic inflammatory response syndrome 26.13 10.66 76 192325 10636 70725407
Myoglobinuria 26.10 10.66 22 192379 1013 70735030
Vomiting 26.10 10.66 1329 191072 591782 70144261
Post-injection delirium sedation syndrome 26.08 10.66 17 192384 525 70735518
Aspiration 26.05 10.66 106 192295 17569 70718474
Rebound effect 26.03 10.66 53 192348 5918 70730125
Hepatic cirrhosis 25.93 10.66 27 192374 30704 70705339
Reflexes abnormal 25.89 10.66 20 192381 812 70735231
Suspected suicide attempt 25.88 10.66 14 192387 304 70735739
Haemorrhoids 25.80 10.66 19 192382 25569 70710474
Productive cough 25.70 10.66 117 192284 78220 70657823
Injection site haemorrhage 25.68 10.66 19 192382 25508 70710535
Illness 25.64 10.66 29 192372 31762 70704281
Diffuse large B-cell lymphoma 25.62 10.66 3 192398 13299 70722744
Self-injurious ideation 25.56 10.66 38 192363 3300 70732743
Therapy interrupted 25.55 10.66 18 192383 24784 70711259
Ketosis-prone diabetes mellitus 25.53 10.66 7 192394 18 70736025
Dyscalculia 25.19 10.66 9 192392 67 70735976
Stress 25.09 10.66 97 192304 67869 70668174
Second primary malignancy 25 10.66 3 192398 13048 70722995
Hernia 24.88 10.66 5 192396 14855 70721188
Antisocial behaviour 24.80 10.66 17 192384 572 70735471
Necrotising colitis 24.78 10.66 21 192380 974 70735069
Decreased gait velocity 24.67 10.66 11 192390 154 70735889
Anxiety 24.64 10.66 777 191624 219553 70516490
Pancreatic carcinoma 24.64 10.66 3 192398 12901 70723142
Metabolic disorder 24.59 10.66 62 192339 7978 70728065
Hypotelorism of orbit 24.56 10.66 5 192396 0 70736043
Eye pain 24.48 10.66 34 192367 34068 70701975
Blood urine present 24.31 10.66 11 192390 19342 70716701
Neuralgia 24.28 10.66 25 192376 28578 70707465
Clonus 24.26 10.66 53 192348 6215 70729828
Lactate pyruvate ratio increased 24.21 10.66 9 192392 76 70735967
Cerebral ventricle dilatation 24.21 10.66 21 192380 1006 70735037
Paraesthesia oral 24.17 10.66 6 192395 15411 70720632
Skin disorder 24.15 10.66 28 192373 30329 70705714
Candida infection 24.13 10.66 35 192366 34438 70701605
Muscle twitching 23.95 10.66 112 192289 19715 70716328
Sciatica 23.92 10.66 19 192382 24608 70711435
COVID-19 pneumonia 23.91 10.66 15 192386 21954 70714089
Blood loss anaemia 23.88 10.66 5 192396 14436 70721607
Aminoaciduria 23.76 10.66 12 192389 225 70735818
Postural tremor 23.74 10.66 17 192384 614 70735429
Dysphonia 23.72 10.66 64 192337 50036 70686007
Ammonia abnormal 23.69 10.66 11 192390 170 70735873
Pectus excavatum 23.62 10.66 6 192395 10 70736033
Shock 23.56 10.66 189 192212 40236 70695807
Brain malformation 23.45 10.66 8 192393 51 70735992
Angina unstable 23.39 10.66 7 192394 15886 70720157
Transplant rejection 23.34 10.66 10 192391 18161 70717882
Post-anoxic myoclonus 23.32 10.66 8 192393 52 70735991
Oral candidiasis 23.31 10.66 20 192381 24932 70711111
Ultrasound ovary abnormal 23.15 10.66 9 192392 87 70735956
Oral herpes 23.07 10.66 19 192382 24167 70711876
Blood gases abnormal 23.06 10.66 21 192380 1073 70734970
Motor dysfunction 23.06 10.66 83 192318 12987 70723056
Product administration error 22.99 10.66 148 192253 29375 70706668
Ageusia 22.89 10.66 6 192395 14856 70721187
Gamma-glutamyltransferase increased 22.84 10.66 224 192177 50461 70685582
Injection site rash 22.79 10.66 8 192393 16402 70719641
Tenosynovitis 22.79 10.66 5 192396 13971 70722072
Hyperphagia 22.75 10.66 30 192371 2329 70733714
Adrenal insufficiency 22.57 10.66 21 192380 25174 70710869
Gastric ulcer 22.52 10.66 32 192369 31758 70704285
Joint effusion 22.45 10.66 7 192394 15470 70720573
Dissociation 22.44 10.66 36 192365 3340 70732703
Blood sodium increased 22.43 10.66 42 192359 4410 70731633
Product administered to patient of inappropriate age 22.32 10.66 44 192357 4799 70731244
Squamous cell carcinoma 22.29 10.66 6 192395 14598 70721445
Sinus tachycardia 22.25 10.66 163 192238 33750 70702293
Blood osmolarity decreased 22.22 10.66 22 192379 1249 70734794
Microstomia 22.22 10.66 5 192396 3 70736040
Crying 22.22 10.66 115 192286 21084 70714959
Nephrocalcinosis 22.21 10.66 23 192378 1378 70734665
Multiple congenital abnormalities 22.20 10.66 9 192392 98 70735945
Sarcopenia 22.17 10.66 14 192387 409 70735634
Lymphangioleiomyomatosis 22.11 10.66 10 192391 145 70735898
Bradypnoea 22.09 10.66 47 192354 5412 70730631
Hyperexplexia 21.94 10.66 7 192394 35 70736008
Gene mutation 21.89 10.66 29 192372 2262 70733781
Diplopia 21.85 10.66 141 192260 28006 70708037
Muscular weakness 21.77 10.66 255 192146 138081 70597962
Skin cancer 21.75 10.66 5 192396 13531 70722512
Intervertebral disc protrusion 21.64 10.66 16 192385 21487 70714556
Colon cancer 21.61 10.66 6 192395 14300 70721743
Ankylosing spondylitis 21.53 10.66 3 192398 11643 70724400
Therapeutic response changed 21.52 10.66 20 192381 1049 70734994
Hip fracture 21.50 10.66 27 192374 28236 70707807
Pneumothorax 21.48 10.66 23 192378 25823 70710220
Dry eye 21.41 10.66 34 192367 32248 70703795
Hypersomnia 21.32 10.66 112 192289 20652 70715391
Developmental regression 21.32 10.66 7 192394 39 70736004
Reduced facial expression 21.29 10.66 29 192372 2323 70733720
Dysphagia 21.29 10.66 427 191974 112407 70623636
Disturbance in social behaviour 21.28 10.66 39 192362 4028 70732015
Tooth infection 21.25 10.66 9 192392 16454 70719589
Nodule 21.23 10.66 14 192387 19955 70716088
IVth nerve disorder 21.21 10.66 6 192395 18 70736025
Clonic convulsion 21.10 10.66 21 192380 1200 70734843
Throat tightness 21.10 10.66 22 192379 25000 70711043
Musculoskeletal discomfort 21.08 10.66 11 192390 17821 70718222
Illogical thinking 21.08 10.66 8 192393 72 70735971
Galactorrhoea 21.07 10.66 35 192366 3343 70732700
Drug dependence 20.95 10.66 173 192228 37148 70698895
Urine amphetamine positive 20.88 10.66 8 192393 74 70735969
Hypophosphataemic osteomalacia 20.85 10.66 12 192389 295 70735748
Talipes 20.78 10.66 9 192392 117 70735926
Circadian rhythm sleep disorder 20.77 10.66 16 192385 647 70735396
Clostridium difficile colitis 20.73 10.66 29 192372 28967 70707076
Hostility 20.71 10.66 28 192373 2227 70733816
Lymphoma 20.69 10.66 8 192393 15454 70720589
Sputum discoloured 20.34 10.66 13 192388 18838 70717205
Irregular sleep phase 20.33 10.66 8 192393 80 70735963
Brain death 20.29 10.66 44 192357 5134 70730909
Blood pressure systolic abnormal 20.29 10.66 5 192396 12904 70723139
Asphyxia 20.26 10.66 68 192333 10274 70725769
Coagulopathy 20.23 10.66 157 192244 33092 70702951
Intermittent explosive disorder 20.20 10.66 5 192396 7 70736036
Full blood count decreased 20.20 10.66 21 192380 23897 70712146
Febrile bone marrow aplasia 20.15 10.66 4 192397 11987 70724056
Chronic kidney disease 20.14 10.66 91 192310 60966 70675077
Feeling of despair 20.04 10.66 30 192371 2621 70733422
Hypothyroidism 20.03 10.66 201 192200 45554 70690489
Procedural pain 20.01 10.66 12 192389 17997 70718046
Magnetic resonance imaging head abnormal 19.99 10.66 29 192372 2463 70733580
Frontotemporal dementia 19.90 10.66 15 192386 587 70735456
Hepatitis C virus test positive 19.88 10.66 12 192389 323 70735720
Drug monitoring procedure incorrectly performed 19.87 10.66 13 192388 404 70735639
Therapeutic product ineffective for unapproved indication 19.81 10.66 9 192392 132 70735911
Hepatic enzyme increased 19.76 10.66 303 192098 156687 70579356
Myelosuppression 19.76 10.66 32 192369 30113 70705930
Metastases to lung 19.74 10.66 10 192391 16474 70719569
Renal cancer 19.68 10.66 4 192397 11792 70724251
Hiatus hernia 19.67 10.66 17 192384 21117 70714926
Diabetic coma 19.66 10.66 20 192381 1173 70734870
Gout 19.65 10.66 20 192381 22986 70713057
Intelligence test abnormal 19.65 10.66 4 192397 0 70736043
Alpers disease 19.65 10.66 4 192397 0 70736043
Hypocarnitinaemia 19.65 10.66 4 192397 0 70736043
Congenital nose malformation 19.65 10.66 4 192397 0 70736043
Blood urea decreased 19.57 10.66 31 192370 2846 70733197
Alcohol abuse 19.56 10.66 43 192358 5064 70730979
Gliosis 19.51 10.66 13 192388 417 70735626
Basilar artery occlusion 19.50 10.66 10 192391 194 70735849
Deja vu 19.49 10.66 7 192394 53 70735990
Carpal tunnel syndrome 19.47 10.66 11 192390 17046 70718997
Anisometropia 19.44 10.66 5 192396 9 70736034
Gallbladder disorder 19.40 10.66 12 192389 17700 70718343
Ear pain 19.33 10.66 28 192373 27571 70708472
Eye movement disorder 19.33 10.66 54 192347 7386 70728657
Patient isolation 19.27 10.66 7 192394 55 70735988
Peripheral venous disease 19.19 10.66 3 192398 10684 70725359
Nephrolithiasis 19.15 10.66 65 192336 47258 70688785
Infusion site pain 19.13 10.66 4 192397 11560 70724483
Neglect of personal appearance 19.11 10.66 9 192392 144 70735899
High arched palate 19.10 10.66 5 192396 10 70736033
Immunodeficiency 19.08 10.66 12 192389 17543 70718500
Gastroenteritis viral 19.08 10.66 18 192383 21437 70714606
Cardiogenic shock 19.04 10.66 44 192357 36263 70699780
White blood cell count decreased 19.01 10.66 600 191801 169541 70566502
Dyspraxia 18.95 10.66 11 192390 275 70735768
Procalcitonin increased 18.92 10.66 29 192372 2587 70733456
Intervertebral disc degeneration 18.92 10.66 7 192394 13893 70722150
Low set ears 18.89 10.66 8 192393 98 70735945
Movement disorder 18.81 10.66 121 192280 24008 70712035
School refusal 18.81 10.66 6 192395 30 70736013
Enterocolitis 18.79 10.66 6 192395 13060 70722983
Mixed delusion 18.78 10.66 5 192396 11 70736032
Blood potassium decreased 18.75 10.66 56 192345 42365 70693678
Hepatic steatosis 18.58 10.66 156 192245 33657 70702386
Swollen tongue 18.55 10.66 46 192355 37000 70699043
Bipolar II disorder 18.54 10.66 12 192389 366 70735677
Monocytosis 18.54 10.66 16 192385 761 70735282
Trismus 18.53 10.66 42 192359 5049 70730994
Hyperreflexia 18.35 10.66 53 192348 7389 70728654
Glioblastoma multiforme 18.31 10.66 20 192381 1274 70734769
Coma hepatic 18.30 10.66 18 192383 1014 70735029
Laboratory test abnormal 18.29 10.66 26 192375 25797 70710246
Therapeutic product effective for unapproved indication 18.27 10.66 8 192393 107 70735936
Enteritis 18.26 10.66 6 192395 12825 70723218
Myelodysplastic syndrome 18.25 10.66 33 192368 29752 70706291
Gynaecomastia 18.20 10.66 50 192351 6773 70729270
Tendon rupture 18.20 10.66 4 192397 11165 70724878
Angioedema 18.17 10.66 106 192295 66504 70669539
Torticollis 18.15 10.66 26 192375 2183 70733860
Atrial flutter 18.14 10.66 17 192384 20310 70715733
Depression suicidal 18.13 10.66 30 192371 2857 70733186
Tooth disorder 18.07 10.66 23 192378 23915 70712128
Conversion disorder 18.06 10.66 23 192378 1725 70734318
Inhibitory drug interaction 18.05 10.66 35 192366 3772 70732271
Osmolar gap increased 18.04 10.66 6 192395 35 70736008
Blister 17.94 10.66 180 192221 100346 70635697
Epileptic aura 17.88 10.66 7 192394 69 70735974
Breast cancer metastatic 17.88 10.66 3 192398 10143 70725900
Feeling cold 17.85 10.66 26 192375 25544 70710499
Cholelithiasis 17.84 10.66 67 192334 47273 70688770
Eye infection 17.81 10.66 3 192398 10115 70725928
Mucosal erosion 17.78 10.66 25 192376 2064 70733979
Niemann-Pick disease 17.75 10.66 8 192393 115 70735928
Condition aggravated 17.74 10.66 1368 191033 426267 70309776
Rickets 17.71 10.66 7 192394 71 70735972
Abdominal distension 17.63 10.66 190 192211 104479 70631564
Shock haemorrhagic 17.55 10.66 14 192387 18092 70717951
Glaucoma 17.52 10.66 14 192387 18078 70717965
Device difficult to use 17.45 10.66 4 192397 10845 70725198
Lipids 17.43 10.66 5 192396 16 70736027
Middle insomnia 17.43 10.66 80 192321 13973 70722070
Blood pyruvic acid increased 17.42 10.66 4 192397 3 70736040
Delusional disorder, mixed type 17.42 10.66 4 192397 3 70736040
Camptodactyly congenital 17.42 10.66 4 192397 3 70736040
Pneumonia fungal 17.41 10.66 3 192398 9950 70726093
Osteomyelitis 17.35 10.66 35 192366 30283 70705760
Troponin increased 17.32 10.66 90 192311 16524 70719519
Hypotonia neonatal 17.28 10.66 7 192394 76 70735967
Influenza like illness 17.27 10.66 105 192296 65226 70670817
Rebound psychosis 17.26 10.66 9 192392 181 70735862
Polyarthritis 17.23 10.66 4 192397 10752 70725291
Aptyalism 17.14 10.66 15 192386 727 70735316
Substance-induced psychotic disorder 17.11 10.66 30 192371 2993 70733050
Parkinsonian gait 17.08 10.66 16 192385 848 70735195
Hyperhomocysteinaemia 17.06 10.66 12 192389 421 70735622
Astigmatism 17.06 10.66 18 192383 1102 70734941
Venoocclusive liver disease 17.05 10.66 4 192397 10674 70725369
Hypercalcaemia 16.98 10.66 43 192358 34342 70701701
Dermatitis contact 16.92 10.66 3 192398 9746 70726297
Personal relationship issue 16.91 10.66 9 192392 189 70735854
Tooth malformation 16.89 10.66 7 192394 81 70735962
Cardiac steatosis 16.87 10.66 6 192395 44 70735999
Product use issue 16.77 10.66 366 192035 179571 70556472
Anticonvulsant drug level therapeutic 16.77 10.66 5 192396 19 70736024
Emotional disorder of childhood 16.77 10.66 5 192396 19 70736024
Compensatory sweating 16.76 10.66 6 192395 45 70735998
Burning sensation 16.73 10.66 80 192321 52790 70683253
Graft versus host disease 16.71 10.66 10 192391 15013 70721030
Wrong schedule 16.70 10.66 11 192390 346 70735697
Transient ischaemic attack 16.68 10.66 66 192335 45878 70690165
Water intoxication 16.68 10.66 15 192386 754 70735289
Grip strength decreased 16.67 10.66 11 192390 15674 70720369
Malignant catatonia 16.65 10.66 12 192389 438 70735605
Cataplexy 16.65 10.66 17 192384 1002 70735041
Influenza B virus test positive 16.59 10.66 11 192390 350 70735693
Blunted affect 16.50 10.66 12 192389 444 70735599
Dermatitis 16.45 10.66 17 192384 19400 70716643
Neutrophilia 16.45 10.66 50 192351 7171 70728872
Congenital foot malformation 16.42 10.66 4 192397 5 70736038
Prothrombin time shortened 16.40 10.66 29 192372 2913 70733130
Haematuria 16.38 10.66 103 192298 63470 70672573
Oxygen saturation decreased 16.31 10.66 220 192181 116209 70619834
Acquired macroglossia 16.29 10.66 9 192392 204 70735839
Lacrimation increased 16.21 10.66 18 192383 19881 70716162
Polydipsia psychogenic 16.21 10.66 9 192392 206 70735837
Opisthotonus 16.19 10.66 14 192387 668 70735375
Bronchiectasis 16.17 10.66 12 192389 16085 70719958
Blood creatinine increased 16.02 10.66 282 192119 142719 70593324
Clinodactyly 16.01 10.66 5 192396 23 70736020
Gender dysphoria 16.00 10.66 6 192395 52 70735991
Mucosal ulceration 15.99 10.66 22 192379 1779 70734264
Idiosyncratic drug reaction 15.97 10.66 18 192383 1188 70734855
Hepatocellular carcinoma 15.95 10.66 4 192397 10204 70725839
Hepatotoxicity 15.91 10.66 186 192215 43800 70692243
Hypokalaemia 15.90 10.66 255 192146 130933 70605110
Duodenal ulcer 15.86 10.66 11 192390 15269 70720774
Pyromania 15.84 10.66 5 192396 24 70736019
Subacute sclerosing panencephalitis 15.81 10.66 6 192395 54 70735989
Thermal burn 15.81 10.66 46 192355 6440 70729603
Mastication disorder 15.79 10.66 26 192375 2466 70733577
Tearfulness 15.66 10.66 39 192362 4981 70731062
Extensor plantar response 15.64 10.66 21 192380 1659 70734384
Fistula 15.64 10.66 5 192396 10876 70725167
Rasmussen encephalitis 15.62 10.66 4 192397 7 70736036
Injection site urticaria 15.61 10.66 6 192395 11632 70724411
Nose deformity 15.61 10.66 8 192393 155 70735888
Device dislocation 15.60 10.66 23 192378 22484 70713559
Lacrimal gland enlargement 15.51 10.66 5 192396 26 70736017
Osteoporosis 15.48 10.66 74 192327 48833 70687210
Intention tremor 15.46 10.66 14 192387 710 70735333
Patent ductus arteriosus 15.45 10.66 7 192394 102 70735941
Erythema multiforme 15.42 10.66 87 192314 16477 70719566
Haemoglobin decreased 15.40 10.66 431 191970 204728 70531315
Embolism 15.37 10.66 8 192393 12980 70723063
Haematotoxicity 15.35 10.66 9 192392 13665 70722378
Exostosis 15.33 10.66 10 192391 14335 70721708
Posterior reversible encephalopathy syndrome 15.28 10.66 116 192285 24286 70711757
Wound infection 15.27 10.66 15 192386 17527 70718516
Heat stroke 15.27 10.66 20 192381 1543 70734500
Poor venous access 15.25 10.66 11 192390 14960 70721083
Psychomotor disadaptation syndrome 15.20 10.66 5 192396 28 70736015
Snoring 15.19 10.66 38 192363 4866 70731177
Drug eruption 15.18 10.66 169 192232 39327 70696716
Injury 15.16 10.66 109 192292 65136 70670907
Withdrawal catatonia 15.11 10.66 8 192393 166 70735877
Type 1 diabetes mellitus 15.08 10.66 44 192357 6170 70729873
Acute psychosis 15.03 10.66 33 192368 3883 70732160
Pulmonary eosinophilia 15.02 10.66 13 192388 621 70735422
Pleocytosis 14.99 10.66 18 192383 1271 70734772
Epileptic encephalopathy 14.97 10.66 11 192390 414 70735629
Electrocardiogram J wave abnormal 14.96 10.66 4 192397 9 70736034
Congenital renal disorder 14.96 10.66 4 192397 9 70736034
Disease recurrence 14.95 10.66 162 192239 37441 70698602
Poor personal hygiene 14.94 10.66 12 192389 516 70735527
Hyporeflexia 14.94 10.66 30 192371 3317 70732726
Back disorder 14.93 10.66 5 192396 10559 70725484
Sperm concentration decreased 14.91 10.66 6 192395 64 70735979
Diabetic hyperosmolar coma 14.90 10.66 14 192387 745 70735298
Posturing 14.85 10.66 16 192385 1004 70735039
Rotator cuff syndrome 14.84 10.66 8 192393 12726 70723317
Body temperature decreased 14.83 10.66 35 192366 28637 70707406
Near drowning 14.78 10.66 5 192396 31 70736012
Pneumonia bacterial 14.75 10.66 14 192387 16627 70719416
Congenital scoliosis 14.74 10.66 3 192398 0 70736043
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 14.74 10.66 3 192398 0 70736043
Congenital eyelid malformation 14.74 10.66 3 192398 0 70736043
Nasopharyngeal reflux 14.74 10.66 3 192398 0 70736043
Social (pragmatic) communication disorder 14.74 10.66 3 192398 0 70736043
Lisfranc fracture 14.74 10.66 3 192398 0 70736043
Diabetic encephalopathy 14.74 10.66 3 192398 0 70736043
Angular cheilitis 14.68 10.66 13 192388 640 70735403
Gastroenteritis 14.68 10.66 40 192361 31173 70704870
Feminisation acquired 14.64 10.66 5 192396 32 70736011
Cerebral arteriosclerosis 14.63 10.66 14 192387 762 70735281
Oral pain 14.63 10.66 36 192365 29030 70707013
MELAS syndrome 14.61 10.66 8 192393 178 70735865
Anticoagulation drug level decreased 14.57 10.66 8 192393 179 70735864
Blood pressure diastolic decreased 14.55 10.66 30 192371 25750 70710293
Pathogen resistance 14.54 10.66 9 192392 13270 70722773
Tooth abscess 14.49 10.66 11 192390 14578 70721465
Hypoventilation 14.46 10.66 45 192356 6537 70729506
Rotavirus infection 14.43 10.66 13 192388 655 70735388
Retinitis pigmentosa 14.43 10.66 7 192394 120 70735923
Treatment failure 14.37 10.66 290 192111 143852 70592191
Delusional perception 14.37 10.66 10 192391 345 70735698
Brain injury 14.34 10.66 62 192339 10555 70725488
Musculoskeletal chest pain 14.34 10.66 25 192376 22856 70713187
Frequent bowel movements 14.29 10.66 22 192379 21131 70714912
Urine sodium increased 14.26 10.66 8 192393 187 70735856
Abulia 14.20 10.66 15 192386 920 70735123
Escherichia infection 14.18 10.66 14 192387 16317 70719726
Locomotive syndrome 14.14 10.66 4 192397 12 70736031
Amino acid metabolism disorder 14.14 10.66 4 192397 12 70736031
Gingival atrophy 14.14 10.66 6 192395 74 70735969
Unmasking of previously unidentified disease 14.11 10.66 21 192380 1826 70734217
Lip erosion 14.09 10.66 18 192383 1354 70734689
Diverticulum 14.02 10.66 10 192391 13683 70722360
Oesophageal carcinoma 14.01 10.66 4 192397 9362 70726681
Amino acid level increased 14.00 10.66 13 192388 681 70735362
Derealisation 14.00 10.66 19 192382 1517 70734526
Anaemia macrocytic 13.97 10.66 38 192363 5117 70730926
Accidental death 13.96 10.66 32 192369 3876 70732167
Polyserositis 13.95 10.66 12 192389 568 70735475
Renal tubular necrosis 13.91 10.66 26 192375 23145 70712898
Cholangitis 13.84 10.66 7 192394 11542 70724501
Migraine 13.83 10.66 274 192127 71964 70664079
Organising pneumonia 13.78 10.66 5 192396 10045 70725998
Deep vein thrombosis 13.74 10.66 215 192186 110827 70625216
Altered visual depth perception 13.73 10.66 10 192391 371 70735672
Visuospatial deficit 13.69 10.66 5 192396 40 70736003
Slow response to stimuli 13.66 10.66 20 192381 1713 70734330
Small intestinal obstruction 13.65 10.66 29 192372 24626 70711417
Anticholinergic syndrome 13.65 10.66 27 192374 2953 70733090
Mass 13.61 10.66 14 192387 16012 70720031
Toothache 13.61 10.66 18 192383 18412 70717631
CSF oligoclonal band present 13.58 10.66 9 192392 286 70735757
Eosinophil count increased 13.55 10.66 79 192322 15143 70720900
Hypoacusis 13.55 10.66 34 192367 27235 70708808
Sedation complication 13.54 10.66 72 192329 13338 70722705
Lower gastrointestinal haemorrhage 13.51 10.66 12 192389 14708 70721335
Ehlers-Danlos syndrome 13.50 10.66 7 192394 139 70735904
Skin irritation 13.47 10.66 5 192396 9904 70726139
Pancreatitis haemorrhagic 13.44 10.66 13 192388 717 70735326
Pulmonary valve incompetence 13.43 10.66 20 192381 1740 70734303
Dissociative disorder 13.42 10.66 11 192390 487 70735556
Gastrointestinal sounds abnormal 13.41 10.66 37 192364 5024 70731019
Urine calcium/creatinine ratio increased 13.41 10.66 7 192394 141 70735902
Squamous cell carcinoma of skin 13.40 10.66 9 192392 12703 70723340
Factor XIII deficiency 13.39 10.66 6 192395 85 70735958
Bronchospasm 13.31 10.66 26 192375 22766 70713277
Skin fissures 13.25 10.66 7 192394 11263 70724780
Blood parathyroid hormone decreased 13.23 10.66 4 192397 9020 70727023
Personality disorder 13.19 10.66 39 192362 5509 70730534
Malignant melanoma 13.16 10.66 11 192390 13889 70722154
Opsoclonus myoclonus 13.13 10.66 8 192393 219 70735824
Gastric cancer 13.08 10.66 4 192397 8951 70727092
Terminal insomnia 13.00 10.66 15 192386 1015 70735028
Cardiac failure acute 12.99 10.66 17 192384 17470 70718573
Drug screen false positive 12.97 10.66 15 192386 1018 70735025
Lip haemorrhage 12.96 10.66 16 192385 1163 70734880
Intraocular pressure increased 12.96 10.66 4 192397 8897 70727146
Ejaculation disorder 12.93 10.66 11 192390 513 70735530
Tubulointerstitial nephritis 12.92 10.66 142 192259 32934 70703109
False positive investigation result 12.92 10.66 14 192387 884 70735159
Restless legs syndrome 12.92 10.66 90 192311 18338 70717705
Alanine aminotransferase abnormal 12.90 10.66 3 192398 8056 70727987
Neck pain 12.90 10.66 117 192284 66540 70669503
Illusion 12.87 10.66 19 192382 1640 70734403
Coma blister 12.84 10.66 8 192393 228 70735815
Precocious puberty 12.82 10.66 9 192392 315 70735728
Adverse event 12.81 10.66 80 192321 49381 70686662
Strabismus 12.79 10.66 23 192378 2341 70733702
Inappropriate schedule of product administration 12.72 10.66 210 192191 107345 70628698
Tubo-ovarian abscess 12.69 10.66 9 192392 320 70735723
Dacryoadenitis acquired 12.67 10.66 3 192398 3 70736040
Coloboma 12.67 10.66 3 192398 3 70736040
Hepatitis fulminant 12.66 10.66 43 192358 6538 70729505
Dry mouth 12.64 10.66 126 192275 70331 70665712
Hepatomegaly 12.60 10.66 86 192315 17406 70718637
Megacolon 12.58 10.66 27 192374 3129 70732914
Immunosuppressant drug level increased 12.55 10.66 3 192398 7904 70728139
Cerebral palsy 12.54 10.66 7 192394 162 70735881
Skin haemorrhage 12.46 10.66 6 192395 10174 70725869
Infertility male 12.41 10.66 6 192395 102 70735941
SJS-TEN overlap 12.38 10.66 11 192390 544 70735499
Seasonal allergy 12.36 10.66 11 192390 13473 70722570
Musculoskeletal disorder 12.35 10.66 22 192379 19949 70716094
Serositis 12.28 10.66 13 192388 799 70735244
Autoimmune hepatitis 12.25 10.66 7 192394 10779 70725264
Wrong product administered 12.24 10.66 50 192351 8301 70727742
Retinal function test abnormal 12.21 10.66 3 192398 4 70736039
Compulsive sexual behaviour 12.19 10.66 8 192393 250 70735793
Hydronephrosis 12.19 10.66 14 192387 15228 70720815
Blood insulin increased 12.17 10.66 9 192392 342 70735701
Cyst 12.12 10.66 10 192391 12709 70723334
Blood calcium decreased 12.10 10.66 39 192362 28807 70707236
Groin pain 12.07 10.66 9 192392 12033 70724010
Granuloma 12.06 10.66 3 192398 7692 70728351
Hyperpyrexia 12.04 10.66 37 192364 5337 70730706
Lipids abnormal 12.03 10.66 11 192390 565 70735478
Granuloma skin 12.03 10.66 3 192398 7679 70728364
Pupillary reflex impaired 12.02 10.66 27 192374 3227 70732816
Emotional disorder 12.01 10.66 69 192332 13157 70722886
Attention-seeking behaviour 12.00 10.66 6 192395 110 70735933
Endocarditis 11.98 10.66 6 192395 9948 70726095
Blood citric acid increased 11.98 10.66 5 192396 59 70735984
Eczema 11.97 10.66 49 192352 33732 70702311
Respiratory syncytial virus infection 11.96 10.66 3 192398 7652 70728391
Spinal disorder 11.96 10.66 5 192396 9215 70726828
Sinus bradycardia 11.94 10.66 107 192294 23516 70712527
Neutrophil count decreased 11.93 10.66 304 192097 83252 70652791
Vascular encephalopathy 11.92 10.66 11 192390 572 70735471
Nipple disorder 11.92 10.66 7 192394 179 70735864
Dysuria 11.90 10.66 74 192327 45720 70690323
Sleep-related eating disorder 11.89 10.66 12 192389 697 70735346
Macroglossia 11.87 10.66 15 192386 1116 70734927
Acute generalised exanthematous pustulosis 11.87 10.66 77 192324 15320 70720723
Herbal interaction 11.87 10.66 10 192391 460 70735583
Nephropathy toxic 11.81 10.66 20 192381 18494 70717549
Proctalgia 11.79 10.66 4 192397 8379 70727664
Acne 11.77 10.66 32 192369 24957 70711086
Spinal fracture 11.72 10.66 16 192385 16151 70719892
Pulmonary thrombosis 11.72 10.66 8 192393 11200 70724843
Rash morbilliform 11.71 10.66 37 192364 5418 70730625
Cytotoxic oedema 11.68 10.66 9 192392 364 70735679
Hyperdynamic left ventricle 11.68 10.66 9 192392 364 70735679
Spinal compression fracture 11.68 10.66 15 192386 15538 70720505
Thyroxine free decreased 11.67 10.66 14 192387 988 70735055
Gastrointestinal pain 11.66 10.66 4 192397 8323 70727720
Coronary artery occlusion 11.66 10.66 13 192388 14332 70721711
Hyperthyroidism 11.66 10.66 23 192378 20068 70715975
Breast cancer female 11.63 10.66 7 192394 10479 70725564
Blood bicarbonate increased 11.62 10.66 15 192386 1140 70734903
Eclampsia 11.61 10.66 7 192394 188 70735855
Renal injury 11.60 10.66 16 192385 16078 70719965
Cardiovascular disorder 11.59 10.66 17 192384 16653 70719390
Pneumonia viral 11.59 10.66 4 192397 8288 70727755
Hypomagnesaemia 11.59 10.66 64 192337 40700 70695343
Optic atrophy 11.58 10.66 19 192382 1796 70734247
Heparin-induced thrombocytopenia 11.57 10.66 5 192396 9032 70727011
Labelled drug-drug interaction medication error 11.55 10.66 108 192293 24019 70712024
Haematuria traumatic 11.54 10.66 7 192394 190 70735853
Waxy flexibility 11.52 10.66 8 192393 275 70735768
Non-cardiac chest pain 11.52 10.66 5 192396 9010 70727033
Upper-airway cough syndrome 11.51 10.66 6 192395 9725 70726318
Insomnia 11.51 10.66 711 191690 217095 70518948
Tuberculosis 11.49 10.66 14 192387 14834 70721209
Drug half-life reduced 11.46 10.66 3 192398 6 70736037
Congenital renal cyst 11.46 10.66 3 192398 6 70736037
Ornithine transcarbamoylase deficiency 11.46 10.66 3 192398 6 70736037
Arthritis bacterial 11.46 10.66 4 192397 8229 70727814
Sleep disorder 11.42 10.66 259 192142 69613 70666430
Mitochondrial enzyme deficiency 11.41 10.66 4 192397 28 70736015
Personality change 11.38 10.66 51 192350 8819 70727224
Post procedural infection 11.36 10.66 7 192394 10346 70725697
Ejection fraction decreased 11.29 10.66 44 192357 30718 70705325
CSF white blood cell count positive 11.29 10.66 4 192397 29 70736014
Plasmodium falciparum infection 11.28 10.66 5 192396 69 70735974
Muscle tone disorder 11.27 10.66 6 192395 126 70735917
Genital erosion 11.27 10.66 9 192392 384 70735659
Drug-disease interaction 11.27 10.66 13 192388 880 70735163
Malabsorption 11.26 10.66 33 192368 4637 70731406
Hyporesponsive to stimuli 11.20 10.66 19 192382 1846 70734197
Internal haemorrhage 11.20 10.66 4 192397 8112 70727931
Cardiac failure chronic 11.19 10.66 7 192394 10262 70725781
Arthropod bite 11.18 10.66 3 192398 7312 70728731
Libido increased 11.17 10.66 19 192382 1850 70734193
Illiteracy 11.17 10.66 4 192397 30 70736013
Aphthous ulcer 11.15 10.66 14 192387 14642 70721401
Coma acidotic 11.14 10.66 6 192395 129 70735914
Poriomania 11.13 10.66 7 192394 203 70735840
Skin reaction 11.13 10.66 13 192388 14036 70722007
Embolic stroke 11.12 10.66 3 192398 7286 70728757
Acute pulmonary oedema 11.07 10.66 12 192389 13400 70722643
Antidepressant drug level increased 11.07 10.66 9 192392 394 70735649
Blood bicarbonate decreased 11.05 10.66 34 192367 4907 70731136
Therapeutic product effect variable 11.05 10.66 18 192383 1692 70734351
Cyclothymic disorder 11.04 10.66 7 192394 206 70735837
Urosepsis 11.03 10.66 31 192370 23918 70712125
Diverticulum intestinal 11.03 10.66 4 192397 8037 70728006
Electrocardiogram T wave abnormal 11.01 10.66 27 192374 3415 70732628
Hepatocellular injury 11.00 10.66 181 192220 45910 70690133
Monocyte count decreased 10.98 10.66 25 192376 3014 70733029
Acidosis 10.98 10.66 86 192315 18177 70717866
Large intestine polyp 10.96 10.66 9 192392 11467 70724576
Blood bicarbonate abnormal 10.94 10.66 6 192395 134 70735909
Synovial cyst 10.93 10.66 5 192396 8737 70727306
Multiple sclerosis relapse 10.92 10.66 70 192331 42947 70693096
Laryngeal stenosis 10.91 10.66 13 192388 911 70735132
Skin discharge 10.90 10.66 5 192396 75 70735968
Excessive masturbation 10.90 10.66 5 192396 75 70735968
Tooth extraction 10.86 10.66 7 192394 10100 70725943
Gaucher's disease 10.84 10.66 4 192397 33 70736010
Self esteem decreased 10.80 10.66 13 192388 920 70735123
Drug-induced liver injury 10.79 10.66 213 192188 55900 70680143
Cytopenia 10.79 10.66 19 192382 17304 70718739
Phlebitis superficial 10.75 10.66 11 192390 650 70735393
Electrocardiogram QT shortened 10.75 10.66 7 192394 216 70735827
Dependence 10.73 10.66 21 192380 2279 70733764

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal anticonvulsant syndrome 149.99 22.92 41 839 0 88912
Congenital nose malformation 58.31 22.92 16 864 0 88912
Low set ears 42.14 22.92 15 865 20 88892
Dysmorphism 37.27 22.92 32 848 402 88510
Cardiomegaly 29.12 22.92 8 872 0 88912
Developmental delay 28.09 22.92 14 866 61 88851

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:35471 psychotropic drugs
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:63726 neuroprotective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase-related protein 1 Enzyme IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
1069-66-5 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL433 ChEMBL_ID
D014635 MESH_DESCRIPTOR_UI
3121 PUBCHEM_CID
3300 INN_ID
7009 IUPHAR_LIGAND_ID
614OI1Z5WI UNII
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
5641004 SNOMEDCT_US
CHEMBL2315212 ChEMBL_ID
5132 INN_ID
33433-82-8 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 31 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 31 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections