valproic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • divalproex sodium
  • depakote
  • epival
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1730.51 10.31 1703 99542 121351 46463466
Hyperammonaemic encephalopathy 1038.21 10.31 314 100931 1668 46583149
Epilepsy 998.49 10.31 629 100616 23109 46561708
Hyperammonaemia 886.71 10.31 347 100898 4369 46580448
Status epilepticus 800.51 10.31 452 100793 13527 46571290
Drug interaction 752.30 10.31 1474 99771 201620 46383197
Foetal anticonvulsant syndrome 584.33 10.31 146 101099 310 46584507
Aggression 449.83 10.31 382 100863 22362 46562455
Somnolence 436.29 10.31 1013 100232 155508 46429309
Rheumatoid arthritis 427.40 10.31 23 101222 240192 46344625
Generalised tonic-clonic seizure 412.82 10.31 393 100852 26729 46558088
Sopor 410.62 10.31 342 100903 19486 46565331
Ammonia increased 392.00 10.31 191 101054 4186 46580631
Mania 383.72 10.31 258 100987 10588 46574229
Psychotic disorder 379.39 10.31 346 100899 22275 46562542
Toxicity to various agents 368.17 10.31 1151 100094 210615 46374202
Sedation 343.01 10.31 329 100916 22581 46562236
Arthralgia 338.79 10.31 185 101060 364418 46220399
Granulocytopenia 338.78 10.31 184 101061 5089 46579728
Dysmorphism 325.90 10.31 131 101114 1776 46583041
Coma 325.35 10.31 508 100737 57841 46526976
Overdose 317.35 10.31 690 100555 101289 46483528
Pain 311.79 10.31 346 100899 476602 46108215
Intentional self-injury 311.73 10.31 320 100925 23846 46560971
Intentional overdose 311.32 10.31 528 100717 64416 46520401
Petit mal epilepsy 307.98 10.31 147 101098 3073 46581744
Parkinsonism 305.21 10.31 199 101046 7749 46577068
Neuroleptic malignant syndrome 301.76 10.31 225 101020 10897 46573920
Drug abuse 288.81 10.31 504 100741 62904 46521913
Tremor 284.91 10.31 714 100531 114925 46469892
Extrapyramidal disorder 283.70 10.31 218 101027 11050 46573767
Foetal exposure during pregnancy 267.97 10.31 332 100913 30415 46554402
Abnormal behaviour 261.07 10.31 273 100972 20785 46564032
Multiple-drug resistance 257.28 10.31 121 101124 2444 46582373
Agitation 251.73 10.31 440 100805 54975 46529842
Dyspnoea 250.77 10.31 461 100784 515087 46069730
Suicide attempt 250.01 10.31 437 100808 54599 46530218
Drug level increased 244.75 10.31 248 100997 18193 46566624
Drug level decreased 239.26 10.31 153 101092 5759 46579058
Drug reaction with eosinophilia and systemic symptoms 236.79 10.31 306 100939 29242 46555575
Diarrhoea 232.90 10.31 547 100698 559055 46025762
Speech disorder developmental 226.69 10.31 68 101177 349 46584468
Fatigue 224.18 10.31 633 100612 608064 45976753
Antipsychotic drug level increased 223.62 10.31 118 101127 3074 46581743
Ataxia 221.75 10.31 207 101038 13723 46571094
Developmental delay 215.21 10.31 85 101160 1097 46583720
Depressed level of consciousness 202.26 10.31 367 100878 47202 46537615
Cognitive disorder 199.79 10.31 317 100928 36566 46548251
Nausea 198.40 10.31 795 100450 686659 45898158
Joint swelling 196.69 10.31 58 101187 166015 46418802
Bipolar disorder 185.38 10.31 141 101104 7036 46577781
Salivary hypersecretion 185.21 10.31 135 101110 6310 46578507
Anticonvulsant drug level increased 180.44 10.31 79 101166 1341 46583476
Myoclonic epilepsy 177.29 10.31 69 101176 854 46583963
Autism spectrum disorder 169.12 10.31 59 101186 523 46584294
Hypernatraemia 165.87 10.31 126 101119 6275 46578542
Sudden unexplained death in epilepsy 165.23 10.31 49 101196 240 46584577
Anticonvulsant drug level decreased 160.65 10.31 70 101175 1174 46583643
Peripheral swelling 160.38 10.31 71 101174 158000 46426817
Irritability 158.43 10.31 250 100995 28696 46556121
Encephalopathy 156.77 10.31 270 100975 33319 46551498
Hypothermia 154.67 10.31 160 101085 12023 46572794
Pain in extremity 152.27 10.31 203 101042 258477 46326340
Infusion related reaction 149.40 10.31 21 101224 101187 46483630
Schizophrenia 149.39 10.31 134 101111 8434 46576383
Cough 148.87 10.31 168 101077 230081 46354736
Intellectual disability 145.37 10.31 55 101190 627 46584190
Hallucination, auditory 143.34 10.31 145 101100 10611 46574206
Anticonvulsant drug level above therapeutic 138.92 10.31 49 101196 450 46584367
Stevens-Johnson syndrome 134.17 10.31 206 101039 23091 46561726
Schizoaffective disorder 131.93 10.31 64 101181 1388 46583429
Nasopharyngitis 131.59 10.31 86 101159 153912 46430905
Delusion 131.47 10.31 141 101104 11047 46573770
Learning disorder 130.49 10.31 45 101200 384 46584433
Congenital nose malformation 128.84 10.31 40 101205 235 46584582
Partial seizures 128.45 10.31 98 101147 4912 46579905
Confusional state 127.31 10.31 683 100562 159209 46425608
Electroencephalogram abnormal 124.91 10.31 86 101159 3668 46581149
Fanconi syndrome 123.90 10.31 54 101191 906 46583911
Catatonia 122.39 10.31 85 101160 3677 46581140
Headache 121.78 10.31 579 100666 477773 46107044
Drug withdrawal convulsions 121.52 10.31 59 101186 1282 46583535
Treatment noncompliance 120.81 10.31 225 101020 29506 46555311
Abdominal discomfort 120.47 10.31 91 101154 151074 46433743
Electrocardiogram QT prolonged 120.06 10.31 311 100934 51014 46533803
Sinusitis 119.94 10.31 66 101179 129702 46455115
Back pain 118.35 10.31 170 101075 209869 46374948
Hypotonia 117.16 10.31 115 101130 8114 46576703
Psychogenic seizure 114.98 10.31 55 101190 1155 46583662
Disturbance in attention 114.93 10.31 228 101017 31332 46553485
Disorientation 114.87 10.31 250 100995 36668 46548149
Altered state of consciousness 113.32 10.31 191 101054 23157 46561660
Arthropathy 113.02 10.31 23 101222 84677 46500140
Suicidal ideation 112.26 10.31 322 100923 56060 46528757
Contraindicated product administered 108.16 10.31 21 101224 79926 46504891
Muscle rigidity 105.70 10.31 119 101126 9842 46574975
Anticonvulsant drug level below therapeutic 104.96 10.31 42 101203 562 46584255
Injection site pain 104.19 10.31 51 101194 107101 46477716
Psychomotor hyperactivity 100.57 10.31 114 101131 9499 46575318
Dysarthria 100.10 10.31 239 101006 37259 46547558
Bradyphrenia 99.95 10.31 93 101152 6137 46578680
Product substitution issue 99.63 10.31 142 101103 14889 46569928
Anaemia 95.85 10.31 263 100982 255516 46329301
Blood creatine phosphokinase increased 95.83 10.31 196 101049 27528 46557289
Swelling 95.34 10.31 78 101167 124433 46460384
Meningomyelocele 94.99 10.31 37 101208 459 46584358
Hyperprolactinaemia 94.81 10.31 66 101179 2866 46581951
Focal dyscognitive seizures 94.60 10.31 65 101180 2763 46582054
Product residue present 93.12 10.31 73 101172 3809 46581008
Febrile neutropenia 92.06 10.31 45 101200 94582 46490235
Pruritus 91.69 10.31 248 100997 242104 46342713
Hypomania 91.45 10.31 76 101169 4312 46580505
Psychomotor retardation 91.26 10.31 67 101178 3166 46581651
Akathisia 90.25 10.31 97 101148 7617 46577200
Weight increased 90.07 10.31 638 100607 163835 46420982
Tardive dyskinesia 88.51 10.31 95 101150 7448 46577369
Skull malformation 88.40 10.31 32 101213 319 46584498
Cardiac failure congestive 87.20 10.31 45 101200 91705 46493112
Myoclonus 87.01 10.31 130 101115 14222 46570595
Atonic seizures 87.00 10.31 37 101208 583 46584234
Arthritis 84.43 10.31 31 101214 77285 46507532
Plasma cell myeloma 83.09 10.31 3 101242 44475 46540342
Injection site erythema 82.71 10.31 29 101216 74398 46510419
Death 82.39 10.31 411 100834 335137 46249680
Psychomotor skills impaired 82.13 10.31 54 101191 2132 46582685
Pneumonia aspiration 81.74 10.31 199 101046 31406 46553411
Carnitine deficiency 81.19 10.31 24 101221 116 46584701
Drug intolerance 79.87 10.31 122 101123 146927 46437890
Herpes zoster 79.74 10.31 24 101221 67848 46516969
Drug ineffective for unapproved indication 76.64 10.31 132 101113 16281 46568536
Low set ears 75.23 10.31 27 101218 262 46584555
Differential white blood cell count abnormal 74.90 10.31 34 101211 631 46584186
Delirium 73.49 10.31 212 101033 37016 46547801
Neuropathy peripheral 73.30 10.31 54 101191 90839 46493978
Propofol infusion syndrome 72.69 10.31 35 101210 746 46584071
Psoriasis 72.56 10.31 40 101205 78564 46506253
Speech disorder 71.43 10.31 206 101039 35961 46548856
Completed suicide 71.29 10.31 551 100694 145369 46439448
Paradoxical drug reaction 71.07 10.31 51 101194 2325 46582492
Impulsive behaviour 70.88 10.31 43 101202 1472 46583345
Congenital hand malformation 70.80 10.31 26 101219 271 46584546
Exposure during pregnancy 70.20 10.31 438 100807 107774 46477043
Congenital foot malformation 69.45 10.31 23 101222 171 46584646
Toxic epidermal necrolysis 69.44 10.31 151 101094 22127 46562690
Stupor 69.30 10.31 59 101186 3461 46581356
Chest pain 69.25 10.31 177 101068 176147 46408670
Thrombocytopenia 69.24 10.31 491 100754 126090 46458727
Cerebral atrophy 69.18 10.31 67 101178 4649 46580168
Rhabdomyolysis 69.03 10.31 224 101021 41685 46543132
Influenza 68.23 10.31 56 101189 89214 46495603
Persecutory delusion 67.76 10.31 51 101194 2504 46582313
Tonic convulsion 66.64 10.31 37 101208 1069 46583748
Mental disorder 66.51 10.31 149 101096 22276 46562541
Osteoarthritis 65.84 10.31 26 101219 61999 46522818
Affect lability 65.70 10.31 84 101161 7936 46576881
Nystagmus 65.51 10.31 71 101174 5628 46579189
Bipolar I disorder 65.02 10.31 41 101204 1505 46583312
Drug level below therapeutic 64.68 10.31 54 101191 3083 46581734
Drug resistance 63.86 10.31 126 101119 17242 46567575
Acidosis hyperchloraemic 63.83 10.31 25 101220 315 46584502
Gastrointestinal haemorrhage 63.65 10.31 45 101200 77328 46507489
Abdominal pain upper 63.33 10.31 138 101107 145167 46439650
Infantile spasms 62.60 10.31 23 101222 240 46584577
Psychiatric symptom 62.44 10.31 62 101183 4435 46580382
Hand deformity 62.35 10.31 3 101242 34571 46550246
Dyskinesia 62.27 10.31 170 101075 28755 46556062
Ear malformation 61.54 10.31 21 101224 173 46584644
Hypersensitivity 61.28 10.31 148 101097 150173 46434644
Dystonia 61.26 10.31 97 101148 11160 46573657
Talipes 60.89 10.31 38 101207 1369 46583448
Ileus paralytic 60.77 10.31 60 101185 4263 46580554
Bronchitis 60.39 10.31 85 101160 105894 46478923
Urticaria 60.05 10.31 102 101143 117790 46467027
Limb malformation 59.72 10.31 26 101219 435 46584382
Abdominal pain 59.14 10.31 277 100968 229754 46355063
Congenital eyelid malformation 58.96 10.31 12 101233 3 46584814
Malignant neoplasm progression 58.54 10.31 34 101211 64892 46519925
Nasal congestion 58.38 10.31 16 101229 48097 46536720
Product dose omission issue 58.15 10.31 180 101065 168340 46416477
Language disorder 58.14 10.31 38 101207 1485 46583332
Toxic encephalopathy 58.07 10.31 63 101182 4999 46579818
Educational problem 57.36 10.31 22 101223 261 46584556
Learning disability 57.20 10.31 17 101228 84 46584733
Myocarditis 57.11 10.31 77 101168 7662 46577155
Suicidal behaviour 56.50 10.31 45 101200 2403 46582414
Mitochondrial DNULL mutation 56.25 10.31 21 101224 230 46584587
Atrial septal defect 56.14 10.31 69 101176 6263 46578554
Lethargy 55.41 10.31 239 101006 50932 46533885
Dementia 54.51 10.31 108 101137 14822 46569995
Abortion spontaneous 54.48 10.31 213 101032 43433 46541384
Brain oedema 53.92 10.31 97 101148 12381 46572436
Behaviour disorder 53.91 10.31 40 101205 1921 46582896
Flushing 53.91 10.31 37 101208 64577 46520240
Leukopenia 53.65 10.31 291 100954 68052 46516765
Dyspnoea exertional 53.50 10.31 21 101224 50268 46534549
Atrial fibrillation 53.34 10.31 89 101156 103501 46481316
Fluid retention 53.19 10.31 22 101223 51024 46533793
Paranoia 53.16 10.31 88 101157 10509 46574308
Arnold-Chiari malformation 53.08 10.31 24 101221 441 46584376
Gingival hypertrophy 52.95 10.31 35 101210 1394 46583423
White blood cell count increased 52.95 10.31 213 101032 44006 46540811
Chest discomfort 51.82 10.31 72 101173 90197 46494620
Cerebellar atrophy 51.54 10.31 26 101219 615 46584202
Hypokinesia 51.48 10.31 90 101155 11232 46573585
Productive cough 51.03 10.31 23 101222 50692 46534125
Systemic lupus erythematosus 50.91 10.31 40 101205 65140 46519677
Injection site reaction 50.87 10.31 20 101225 47829 46536988
Blood pressure increased 50.60 10.31 126 101119 126540 46458277
Injection site pruritus 50.56 10.31 12 101233 39731 46545086
Mental impairment 50.25 10.31 94 101151 12362 46572455
Oculogyric crisis 50.11 10.31 32 101213 1201 46583616
Resting tremor 50.09 10.31 26 101219 654 46584163
Intentional product use issue 49.96 10.31 26 101219 52754 46532063
Microcephaly 49.80 10.31 26 101219 662 46584155
Neutrophil count increased 49.52 10.31 101 101144 14152 46570665
Myalgia 49.51 10.31 122 101123 122966 46461851
Infection 49.48 10.31 138 101107 133454 46451363
Loss of consciousness 49.15 10.31 402 100843 107836 46476981
Rhinorrhoea 48.93 10.31 21 101224 47644 46537173
Restlessness 48.12 10.31 143 101102 25381 46559436
Spina bifida 47.80 10.31 25 101220 639 46584178
Hypoaesthesia 47.67 10.31 118 101127 118751 46466066
Bone pain 47.59 10.31 21 101224 46869 46537948
Drug hypersensitivity 47.27 10.31 322 100923 243503 46341314
Malaise 47.15 10.31 475 100770 330757 46254060
Thrombosis 46.92 10.31 32 101213 56037 46528780
Asthenia 46.84 10.31 440 100805 310635 46274182
Pleurothotonus 46.76 10.31 30 101215 1135 46583682
Selective eating disorder 46.65 10.31 35 101210 1710 46583107
Glossodynia 46.44 10.31 19 101226 44354 46540463
Respiratory depression 46.13 10.31 87 101158 11513 46573304
Injection site swelling 46.03 10.31 15 101230 40312 46544505
Angiofibroma 45.95 10.31 15 101230 106 46584711
Motor developmental delay 45.56 10.31 14 101231 79 46584738
Blood prolactin increased 44.39 10.31 43 101202 2984 46581833
Musculoskeletal pain 44.33 10.31 52 101193 70076 46514741
Communication disorder 44.30 10.31 39 101206 2394 46582423
Intra-abdominal pressure increased 44.22 10.31 17 101228 203 46584614
Discomfort 44.16 10.31 23 101222 46647 46538170
Tonic clonic movements 44.15 10.31 29 101216 1143 46583674
Seizure cluster 44.07 10.31 16 101229 161 46584656
Poisoning 43.78 10.31 95 101150 13899 46570918
Disease progression 43.78 10.31 82 101163 91218 46493599
Chills 43.67 10.31 89 101156 95943 46488874
Carnitine decreased 43.64 10.31 9 101236 3 46584814
Hyperlactacidaemia 43.35 10.31 37 101208 2178 46582639
Craniosynostosis 42.79 10.31 15 101230 135 46584682
Musculoskeletal stiffness 42.73 10.31 93 101152 97900 46486917
Grandiosity 42.64 10.31 16 101229 178 46584639
Mental status changes 42.08 10.31 179 101066 37909 46546908
Metabolic encephalopathy 41.77 10.31 55 101190 5348 46579469
Neurodevelopmental disorder 41.64 10.31 9 101236 6 46584811
Muscle spasms 41.40 10.31 133 101112 122980 46461837
Wheezing 41.39 10.31 33 101212 53353 46531464
Gene mutation 41.35 10.31 27 101218 1053 46583764
Congenital scoliosis 41.06 10.31 9 101236 7 46584810
Depressive symptom 41.05 10.31 40 101205 2796 46582021
Coordination abnormal 40.93 10.31 80 101165 10869 46573948
Eosinophilic pleural effusion 40.83 10.31 11 101234 35 46584782
Antipsychotic drug level decreased 40.79 10.31 15 101230 157 46584660
Psoriatic arthropathy 40.71 10.31 14 101231 36365 46548452
Lip disorder 40.61 10.31 27 101218 1086 46583731
Asterixis 40.48 10.31 28 101217 1203 46583614
Enuresis 40.35 10.31 34 101211 1966 46582851
Affective disorder 40.34 10.31 51 101194 4764 46580053
Depressed mood 40.29 10.31 161 101084 33158 46551659
Pneumonia 40.04 10.31 575 100670 375745 46209072
Rash 39.97 10.31 539 100706 355973 46228844
Strabismus 39.83 10.31 32 101213 1730 46583087
Anaphylactic reaction 39.73 10.31 34 101211 53078 46531739
Mood swings 39.55 10.31 100 101145 16152 46568665
Injection site bruising 39.38 10.31 14 101231 35622 46549195
Logorrhoea 39.36 10.31 36 101209 2323 46582494
Limbic encephalitis 39.33 10.31 16 101229 224 46584593
Pain in jaw 39.24 10.31 17 101228 38355 46546462
Weight decreased 39.11 10.31 282 100963 210567 46374250
Myocardial infarction 38.95 10.31 97 101148 97431 46487386
Hot flush 38.93 10.31 23 101222 43494 46541323
Osteonecrosis of jaw 38.91 10.31 13 101232 34389 46550428
Refusal of treatment by patient 38.62 10.31 53 101192 5362 46579455
Interstitial lung disease 38.60 10.31 36 101209 53913 46530904
Porphyria acute 38.25 10.31 18 101227 364 46584453
Amenorrhoea 38.24 10.31 69 101176 8826 46575991
Adjustment disorder with mixed anxiety and depressed mood 38.16 10.31 12 101233 74 46584743
Bradykinesia 38.07 10.31 45 101200 3921 46580896
Blood pressure systolic increased 38.01 10.31 8 101237 28779 46556038
Psychotic symptom 37.93 10.31 24 101221 886 46583931
Psychotic behaviour 37.75 10.31 21 101224 609 46584208
Hepatic failure 37.66 10.31 158 101087 33258 46551559
Dry skin 37.66 10.31 21 101224 40995 46543822
Myopia 37.48 10.31 28 101217 1359 46583458
Change in seizure presentation 37.40 10.31 16 101229 256 46584561
Antipsychotic drug level above therapeutic 37.20 10.31 24 101221 917 46583900
Epistaxis 37.19 10.31 51 101194 64254 46520563
Poor sucking reflex 36.89 10.31 14 101231 161 46584656
Treatment failure 36.85 10.31 93 101152 92994 46491823
Hallucination 36.73 10.31 209 101036 49742 46535075
Congenital anomaly 36.50 10.31 29 101216 1543 46583274
Impaired healing 36.44 10.31 17 101228 36726 46548091
Pectus excavatum 36.37 10.31 9 101236 18 46584799
Pneumatosis 36.22 10.31 18 101227 412 46584405
Hypophosphataemic osteomalacia 36.15 10.31 13 101232 127 46584690
Oropharyngeal pain 36.10 10.31 66 101179 74102 46510715
Antipsychotic drug level below therapeutic 35.99 10.31 16 101229 282 46584535
Tachycardia 35.96 10.31 352 100893 99270 46485547
Reflexes abnormal 35.92 10.31 20 101225 581 46584236
Fungal infection 35.47 10.31 10 101235 29510 46555307
Anger 35.42 10.31 79 101166 11773 46573044
Bradycardia neonatal 35.34 10.31 20 101225 600 46584217
Polycystic ovaries 35.32 10.31 27 101218 1357 46583460
Hypertension 35.26 10.31 265 100980 196091 46388726
Acute hepatic failure 35.22 10.31 90 101155 14631 46570186
Delusion of grandeur 34.94 10.31 13 101232 141 46584676
Stomatitis 34.85 10.31 59 101186 68238 46516579
Galactorrhoea 34.67 10.31 42 101203 3755 46581062
Partial seizures with secondary generalisation 34.52 10.31 16 101229 312 46584505
Ventricular septal defect 34.23 10.31 43 101202 3991 46580826
Palpitations 34.09 10.31 100 101145 95159 46489658
Paraesthesia 34.06 10.31 135 101110 117302 46467515
Attention deficit hyperactivity disorder 34.03 10.31 32 101213 2140 46582677
Oral mucosa erosion 33.99 10.31 24 101221 1066 46583751
Cardiac failure 33.93 10.31 77 101168 79871 46504946
Therapeutic product effect decreased 33.89 10.31 81 101164 82520 46502297
Cogwheel rigidity 33.55 10.31 27 101218 1463 46583354
Hyperchloraemia 33.27 10.31 20 101225 673 46584144
Diverticulitis 33.21 10.31 15 101230 33024 46551793
Polydipsia 32.80 10.31 38 101207 3241 46581576
Pulmonary arterial hypertension 32.64 10.31 8 101237 25920 46558897
Retinogram abnormal 32.60 10.31 12 101233 126 46584691
Metabolic disorder 32.55 10.31 44 101201 4388 46580429
Throat irritation 32.55 10.31 11 101234 28890 46555927
Knee arthroplasty 32.45 10.31 6 101239 23659 46561158
Weight gain poor 32.36 10.31 20 101225 708 46584109
C-reactive protein abnormal 32.36 10.31 4 101241 21266 46563551
Drug level above therapeutic 32.35 10.31 39 101206 3470 46581347
Inflammation 32.10 10.31 35 101210 48746 46536071
Necrosis ischaemic 32.05 10.31 21 101224 824 46583993
Gastrooesophageal reflux disease 32.04 10.31 71 101174 74273 46510544
Glycosuria 31.93 10.31 23 101222 1055 46583762
Posture abnormal 31.91 10.31 31 101214 2159 46582658
Haematochezia 31.90 10.31 21 101224 37472 46547345
Device expulsion 31.87 10.31 10 101235 27532 46557285
Drooling 31.79 10.31 37 101208 3172 46581645
Cataract 31.68 10.31 31 101214 45384 46539433
Rabbit syndrome 31.66 10.31 15 101230 308 46584509
Type 2 diabetes mellitus 31.61 10.31 105 101140 19770 46565047
Nipple disorder 31.58 10.31 11 101234 97 46584720
Urinary incontinence 31.45 10.31 134 101111 28396 46556421
Dyspraxia 31.33 10.31 13 101232 192 46584625
Angiomyolipoma 31.27 10.31 13 101232 193 46584624
Blood lactic acid increased 31.13 10.31 49 101196 5608 46579209
Encephalitis autoimmune 31.06 10.31 23 101222 1101 46583716
Metabolic acidosis 31.01 10.31 166 101079 38614 46546203
Breast hyperplasia 30.88 10.31 14 101231 259 46584558
Acute kidney injury 30.77 10.31 345 100900 235510 46349307
Apathy 30.77 10.31 56 101189 7212 46577605
Congenital hair disorder 30.70 10.31 9 101236 42 46584775
Sluggishness 30.61 10.31 44 101201 4647 46580170
Hyperthermia 30.50 10.31 59 101186 7955 46576862
Sinus rhythm 30.45 10.31 18 101227 587 46584230
Neoplasm progression 30.32 10.31 10 101235 26673 46558144
Screaming 30.29 10.31 36 101209 3155 46581662
Congenital joint malformation 30.18 10.31 7 101238 9 46584808
Renal tubular acidosis 30.08 10.31 26 101219 1557 46583260
Neck pain 29.88 10.31 46 101199 55260 46529557
Camptodactyly congenital 29.76 10.31 7 101238 10 46584807
Brief psychotic disorder, with postpartum onset 29.57 10.31 8 101237 26 46584791
Ovarian granulosa-theca cell tumour 29.34 10.31 8 101237 27 46584790
Nephrogenic diabetes insipidus 29.03 10.31 19 101226 744 46584073
Wound 28.96 10.31 30 101215 42772 46542045
Astigmatism 28.94 10.31 20 101225 858 46583959
Psychiatric decompensation 28.86 10.31 22 101223 1101 46583716
Localised infection 28.71 10.31 8 101237 23793 46561024
Automatism 28.42 10.31 9 101236 57 46584760
Hyperglycinaemia 28.39 10.31 6 101239 3 46584814
Congenital oral malformation 28.34 10.31 12 101233 187 46584630
Cystitis 28.14 10.31 30 101215 42211 46542606
Foetal death 28.09 10.31 60 101185 8683 46576134
Abortion induced 28.02 10.31 66 101179 10194 46574623
Hypersexuality 27.97 10.31 16 101229 490 46584327
Mucosal inflammation 27.89 10.31 26 101219 38950 46545867
Skin ulcer 27.86 10.31 18 101227 32440 46552377
Drop attacks 27.78 10.31 18 101227 693 46584124
Verbal abuse 27.69 10.31 10 101235 99 46584718
Cerebrovascular accident 27.52 10.31 119 101126 100920 46483897
Asthma 27.33 10.31 104 101141 91438 46493379
Subileus 27.07 10.31 33 101212 2970 46581847
Blood gases abnormal 27.03 10.31 17 101228 621 46584196
Pulmonary hypertension 26.97 10.31 23 101222 35970 46548847
Loss of personal independence in daily activities 26.84 10.31 52 101193 57131 46527686
Product use in unapproved indication 26.50 10.31 306 100939 89967 46494850
Cellulitis 26.46 10.31 72 101173 70216 46514601
Constipation 26.26 10.31 246 100999 173851 46410966
Arachnodactyly 26.06 10.31 8 101237 45 46584772
Erythema 25.98 10.31 192 101053 142628 46442189
Cleft palate 25.87 10.31 19 101226 898 46583919
Deafness congenital 25.75 10.31 6 101239 8 46584809
Respiratory disorder neonatal 25.67 10.31 19 101226 909 46583908
Hereditary ataxia 25.37 10.31 7 101238 25 46584792
Monocytosis 25.26 10.31 13 101232 321 46584496
Reduced facial expression 25.15 10.31 21 101224 1199 46583618
Accidental overdose 25.09 10.31 98 101147 19968 46564849
Metastases to bone 24.91 10.31 4 101241 17472 46567345
Mydriasis 24.71 10.31 64 101181 10489 46574328
Illogical thinking 24.70 10.31 8 101237 55 46584762
Urinary tract infection 24.64 10.31 333 100912 219933 46364884
Gait disturbance 24.52 10.31 447 100798 144816 46440001
Palmar-plantar erythrodysaesthesia syndrome 24.43 10.31 7 101238 20444 46564373
Borderline personality disorder 24.36 10.31 17 101228 741 46584076
Obesity 24.35 10.31 77 101168 14129 46570688
Plagiocephaly 24.33 10.31 8 101237 58 46584759
Pancreatitis 24.26 10.31 170 101075 43457 46541360
High arched palate 24.21 10.31 8 101237 59 46584758
Prescribed overdose 24.09 10.31 63 101182 10386 46574431
Bipolar II disorder 24.05 10.31 12 101233 277 46584540
Renal failure 24.02 10.31 146 101099 113448 46471369
Injection site rash 23.99 10.31 3 101242 15810 46569007
Obsessive-compulsive disorder 23.74 10.31 32 101213 3183 46581634
Vomiting 23.74 10.31 775 100470 452019 46132798
Staring 23.69 10.31 22 101223 1448 46583369
Hypertonia 23.64 10.31 38 101207 4428 46580389
Hyponatraemia 23.58 10.31 329 100916 101003 46483814
Akinesia 23.48 10.31 24 101221 1777 46583040
Schizoaffective disorder bipolar type 23.45 10.31 9 101236 107 46584710
Fluid overload 23.43 10.31 15 101230 27170 46557647
Illiteracy 23.34 10.31 5 101240 3 46584814
Aphasia 23.33 10.31 123 101122 28444 46556373
Surgery 23.32 10.31 17 101228 28768 46556049
Balance disorder 23.28 10.31 228 101017 64293 46520524
Neutropenia 23.24 10.31 438 100807 142766 46442051
Unresponsive to stimuli 23.24 10.31 134 101111 32040 46552777
Multiple congenital abnormalities 23.24 10.31 14 101231 473 46584344
Retinitis pigmentosa 23.22 10.31 9 101236 110 46584707
Respiratory acidosis 23.08 10.31 45 101200 6103 46578714
Anticonvulsant drug level abnormal 23.01 10.31 7 101238 38 46584779
Lymphangioleiomyomatosis 22.93 10.31 10 101235 168 46584649
Tic 22.88 10.31 20 101225 1216 46583601
Conversion disorder 22.82 10.31 23 101222 1675 46583142
Hepatotoxicity 22.75 10.31 111 101134 24898 46559919
Pneumonitis 22.75 10.31 17 101228 28403 46556414
Stillbirth 22.55 10.31 46 101199 6445 46578372
Eosinophilia 22.54 10.31 92 101153 19125 46565692
Dysgeusia 22.53 10.31 33 101212 40458 46544359
Gastrointestinal disorder 22.44 10.31 61 101184 59515 46525302
Hirsutism 22.36 10.31 18 101227 976 46583841
Lipids 22.29 10.31 6 101239 19 46584798
Motor dysfunction 22.28 10.31 49 101196 7233 46577584
Right ventricular failure 22.24 10.31 4 101241 16089 46568728
Dehydration 22.14 10.31 230 101015 159310 46425507
Euphoric mood 22.13 10.31 36 101209 4236 46580581
Gaze palsy 22.03 10.31 20 101225 1278 46583539
Joint stiffness 21.98 10.31 16 101229 27092 46557725
Breast cancer 21.70 10.31 41 101204 45477 46539340
Lennox-Gastaut syndrome 21.58 10.31 11 101234 266 46584551
Disinhibition 21.57 10.31 17 101228 894 46583923
Leukocytosis 21.39 10.31 104 101141 23294 46561523
Cardiac disorder 21.36 10.31 39 101206 43819 46540998
Coronary artery disease 21.35 10.31 25 101220 33727 46551090
Congenital central nervous system anomaly 21.32 10.31 12 101233 356 46584461
Dacryostenosis congenital 21.32 10.31 5 101240 7 46584810
Upper respiratory tract infection 21.11 10.31 69 101176 63487 46521330
Full blood count decreased 20.93 10.31 11 101234 22200 46562617
Lactate pyruvate ratio increased 20.91 10.31 7 101238 54 46584763
Hallucinations, mixed 20.71 10.31 33 101212 3816 46581001
Clinodactyly 20.63 10.31 8 101237 98 46584719
Miosis 20.60 10.31 45 101200 6612 46578205
Anomaly of orbit, congenital 20.54 10.31 4 101241 0 46584817
Optic nerve hypoplasia 20.54 10.31 4 101241 0 46584817
Congenital hepatomegaly 20.54 10.31 4 101241 0 46584817
Speech sound disorder 20.54 10.31 4 101241 0 46584817
Congenital cystic kidney disease 20.53 10.31 12 101233 383 46584434
Pulmonary fibrosis 20.38 10.31 9 101236 20083 46564734
Eye movement disorder 20.38 10.31 37 101208 4756 46580061
Nephrocalcinosis 20.37 10.31 17 101228 970 46583847
Metabolic syndrome 20.27 10.31 19 101226 1265 46583552
Hepatic function abnormal 20.25 10.31 136 101109 34285 46550532
Tachyphrenia 20.15 10.31 19 101226 1275 46583542
Mitochondrial enzyme deficiency 20.13 10.31 6 101239 30 46584787
Depression 20.12 10.31 497 100748 169607 46415210
Physical assault 20.12 10.31 17 101228 987 46583830
Mutism 20.07 10.31 19 101226 1281 46583536
Mood altered 20.05 10.31 68 101177 12939 46571878
Drug screen false positive 19.98 10.31 16 101229 861 46583956
Strabismus congenital 19.97 10.31 6 101239 31 46584786
Hypotonia neonatal 19.93 10.31 16 101229 864 46583953
Blood insulin increased 19.93 10.31 8 101237 108 46584709
Pancreatitis necrotising 19.93 10.31 20 101225 1449 46583368
Injection site haemorrhage 19.90 10.31 10 101235 20699 46564118
Hallucination, visual 19.74 10.31 84 101161 17789 46567028
Night sweats 19.71 10.31 18 101227 27232 46557585
Oral pain 19.63 10.31 15 101230 24782 46560035
Stereotypy 19.62 10.31 12 101233 417 46584400
Epileptic encephalopathy 19.43 10.31 10 101235 247 46584570
Echolalia 19.40 10.31 9 101236 176 46584641
Inappropriate antidiuretic hormone secretion 19.39 10.31 71 101174 14031 46570786
Hostility 19.32 10.31 19 101226 1343 46583474
Developmental regression 19.30 10.31 5 101240 13 46584804
Incontinence 19.30 10.31 56 101189 9806 46575011
Haemoptysis 19.30 10.31 17 101228 26172 46558645
Hypothyroidism 19.15 10.31 125 101120 31213 46553604
Presyncope 19.10 10.31 15 101230 24439 46560378
Diabetes mellitus 19.09 10.31 179 101066 49886 46534931
Right ventricular hypertrophy 19.08 10.31 14 101231 661 46584156
Fibromyalgia 19.06 10.31 31 101214 36432 46548385
Dyspepsia 19.03 10.31 80 101165 68392 46516425
Hypermobility syndrome 19.00 10.31 14 101231 665 46584152
Acute generalised exanthematous pustulosis 18.98 10.31 54 101191 9351 46575466
Pancreatitis acute 18.89 10.31 105 101140 24767 46560050
Hiatus hernia 18.88 10.31 8 101237 18294 46566523
Neoplasm malignant 18.88 10.31 14 101231 23485 46561332
Laryngeal stenosis 18.80 10.31 14 101231 676 46584141
Rash maculo-papular 18.79 10.31 114 101131 27760 46557057
Influenza B virus test positive 18.71 10.31 11 101234 355 46584462
Flatulence 18.69 10.31 21 101224 28857 46555960
Sinus congestion 18.69 10.31 3 101242 13106 46571711
Monocyte count decreased 18.66 10.31 21 101224 1736 46583081
Pneumocystis jirovecii pneumonia 18.63 10.31 5 101240 15243 46569574
Food interaction 18.58 10.31 13 101232 569 46584248
Congenital hearing disorder 18.54 10.31 5 101240 16 46584801
Aspiration 18.53 10.31 54 101191 9477 46575340
Ultrasound ovary abnormal 18.49 10.31 7 101238 80 46584737
Polydactyly 18.47 10.31 11 101234 364 46584453
Eye pain 18.43 10.31 20 101225 27920 46556897
Attention-seeking behaviour 18.33 10.31 7 101238 82 46584735
Microstomia 18.31 10.31 4 101241 3 46584814
Hyperkalaemia 18.30 10.31 53 101192 50656 46534161
Ascites 18.29 10.31 32 101213 36552 46548265
Feeling hot 18.23 10.31 34 101211 37894 46546923
Conjunctival hyperaemia 18.16 10.31 22 101223 1967 46582850
Blood count abnormal 18.15 10.31 8 101237 17870 46566947
Haemorrhoids 18.14 10.31 9 101236 18768 46566049
Pulmonary mass 18.11 10.31 8 101237 17849 46566968
Prognathism 18.09 10.31 5 101240 18 46584799
Basal cell carcinoma 18.08 10.31 11 101234 20476 46564341
Prominent epicanthal folds 18.07 10.31 6 101239 45 46584772
Sputum discoloured 18.04 10.31 3 101242 12775 46572042
Metastases to liver 18.02 10.31 10 101235 19575 46565242
Negativism 18.01 10.31 11 101234 381 46584436
Clonus 17.99 10.31 32 101213 4048 46580769
Precocious puberty 17.95 10.31 9 101236 210 46584607
Benign congenital hypotonia 17.78 10.31 4 101241 4 46584813
Acute myocardial infarction 17.78 10.31 26 101219 31898 46552919
Limb discomfort 17.75 10.31 14 101231 22762 46562055
Transient aphasia 17.74 10.31 6 101239 48 46584769
Brain death 17.73 10.31 26 101219 2797 46582020
Clostridium difficile infection 17.66 10.31 17 101228 25086 46559731
Social avoidant behaviour 17.61 10.31 26 101219 2813 46582004
Spinal stenosis 17.59 10.31 3 101242 12540 46572277
Thinking abnormal 17.57 10.31 54 101191 9760 46575057
Hip fracture 17.53 10.31 19 101226 26537 46558280
Medication error 17.51 10.31 121 101124 30790 46554027
Microphthalmos 17.50 10.31 8 101237 151 46584666
Osmolar gap increased 17.48 10.31 5 101240 21 46584796
Sexually inappropriate behaviour 17.40 10.31 7 101238 95 46584722
Micrognathia 17.32 10.31 9 101236 227 46584590
Device issue 17.25 10.31 11 101234 19969 46564848
Drug dependence 17.16 10.31 87 101158 19814 46565003
Drug level changed 17.08 10.31 8 101237 160 46584657
Bursitis 17.03 10.31 11 101234 19831 46564986
Hip arthroplasty 17.02 10.31 9 101236 18103 46566714
Spina bifida occulta 16.89 10.31 4 101241 6 46584811
Drug eruption 16.84 10.31 91 101154 21238 46563579
Cardiac steatosis 16.83 10.31 6 101239 57 46584760
Transfusion 16.82 10.31 4 101241 13227 46571590
Growth retardation 16.77 10.31 15 101230 940 46583877
Congenital musculoskeletal anomaly 16.69 10.31 11 101234 436 46584381
Heart rate decreased 16.55 10.31 27 101218 31696 46553121
Dysphoria 16.51 10.31 33 101212 4556 46580261
Injection site urticaria 16.48 10.31 3 101242 11964 46572853
Neglect of personal appearance 16.48 10.31 7 101238 110 46584707
Perseveration 16.40 10.31 9 101236 254 46584563
Device related infection 16.31 10.31 13 101232 21028 46563789
Faeces discoloured 16.29 10.31 8 101237 16779 46568038
Intentional product misuse 16.26 10.31 165 101080 46963 46537854
Conductive deafness 16.21 10.31 6 101239 64 46584753
Upper gastrointestinal haemorrhage 16.20 10.31 8 101237 16730 46568087
Ketosis-prone diabetes mellitus 16.17 10.31 4 101241 8 46584809
Withdrawal syndrome 16.15 10.31 80 101165 18054 46566763
Cerebral ventricle dilatation 16.14 10.31 15 101230 988 46583829
Oropharyngeal oedema 16.14 10.31 7 101238 116 46584701
Epileptic psychosis 16.02 10.31 5 101240 30 46584787
Renal hypoplasia 15.88 10.31 5 101240 31 46584786
Electrocardiogram J wave abnormal 15.85 10.31 4 101241 9 46584808
Ulcer 15.83 10.31 9 101236 17383 46567434
Lipids abnormal 15.72 10.31 9 101236 276 46584541
Serositis 15.72 10.31 12 101233 602 46584215
Drug monitoring procedure incorrectly performed 15.72 10.31 7 101238 124 46584693
Cerebral palsy 15.72 10.31 7 101238 124 46584693
Contusion 15.71 10.31 118 101127 87369 46497448
Sciatica 15.71 10.31 11 101234 19009 46565808
Self-injurious ideation 15.64 10.31 22 101223 2278 46582539
Reading disorder 15.63 10.31 13 101232 738 46584079
Gastric disorder 15.62 10.31 21 101224 26684 46558133
Hypoplastic left heart syndrome 15.60 10.31 8 101237 196 46584621
Deep vein thrombosis 15.59 10.31 105 101140 79668 46505149
Therapeutic product effective for unapproved indication 15.58 10.31 6 101239 72 46584745
Dyslexia 15.53 10.31 8 101237 198 46584619
Poisoning deliberate 15.50 10.31 45 101200 7881 46576936
Diplopia 15.47 10.31 83 101162 19322 46565495
Rasmussen encephalitis 15.41 10.31 3 101242 0 46584817
Congenital cutis laxa 15.41 10.31 3 101242 0 46584817
Diabetic encephalopathy 15.41 10.31 3 101242 0 46584817
Childhood asthma 15.41 10.31 3 101242 0 46584817
Carnitine palmitoyltransferase deficiency 15.41 10.31 3 101242 0 46584817
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.41 10.31 3 101242 0 46584817
Alpers disease 15.41 10.31 3 101242 0 46584817
Congenital flat feet 15.41 10.31 3 101242 0 46584817
Sedation complication 15.32 10.31 28 101217 3617 46581200
Rectal haemorrhage 15.30 10.31 38 101207 38217 46546600
Congenital laryngeal stridor 15.28 10.31 4 101241 11 46584806
Drug level fluctuating 15.23 10.31 10 101235 394 46584423
Clonic convulsion 15.22 10.31 12 101233 631 46584186
Mitochondrial cytopathy 15.13 10.31 9 101236 297 46584520
Hypersomnia 15.11 10.31 70 101175 15369 46569448
Urine calcium/creatinine ratio increased 15.04 10.31 7 101238 138 46584679
Diverticulum 15.03 10.31 3 101242 11203 46573614
Colitis 15.02 10.31 37 101208 37310 46547507
COVID-19 15.01 10.31 11 101234 18564 46566253
Lip erosion 14.93 10.31 13 101232 786 46584031
Kidney infection 14.84 10.31 9 101236 16780 46568037
Vascular encephalopathy 14.74 10.31 10 101235 416 46584401
Musculoskeletal discomfort 14.73 10.31 6 101239 14050 46570767
Grunting 14.73 10.31 8 101237 221 46584596
Tubo-ovarian abscess 14.71 10.31 9 101236 313 46584504
Urine sodium increased 14.56 10.31 6 101239 87 46584730
False positive investigation result 14.53 10.31 11 101234 545 46584272
Apraxia 14.44 10.31 18 101227 1657 46583160
General physical health deterioration 14.42 10.31 171 101074 115598 46469219
Intestinal strangulation 14.38 10.31 6 101239 90 46584727
Liver function test increased 14.34 10.31 17 101228 22809 46562008
Pulmonary valve stenosis congenital 14.30 10.31 7 101238 155 46584662
Blood triglycerides increased 14.29 10.31 57 101188 11726 46573091
Hypermetropia 14.27 10.31 10 101235 439 46584378
Poor personal hygiene 14.26 10.31 9 101236 331 46584486
Simple partial seizures 14.25 10.31 11 101234 561 46584256
Inappropriate affect 14.24 10.31 13 101232 837 46583980
Bladder sphincter atony 14.09 10.31 7 101238 160 46584657
Sneezing 14.09 10.31 5 101240 12736 46572081
Withdrawal catatonia 14.07 10.31 5 101240 47 46584770
Hyporesponsive to stimuli 14.06 10.31 13 101232 851 46583966
Blood pressure fluctuation 14.02 10.31 28 101217 30420 46554397
Plasmodium falciparum infection 13.98 10.31 5 101240 48 46584769
Lipid metabolism disorder 13.89 10.31 5 101240 49 46584768
Shock 13.88 10.31 88 101157 21757 46563060
Copper deficiency 13.80 10.31 5 101240 50 46584767
Oral herpes 13.79 10.31 13 101232 19377 46565440
Heart rate irregular 13.78 10.31 12 101233 18579 46566238
Ebstein's anomaly 13.76 10.31 4 101241 18 46584799
Dysgraphia 13.75 10.31 23 101222 2769 46582048
Vestibular migraine 13.75 10.31 6 101239 101 46584716
Prothrombin time shortened 13.74 10.31 18 101227 1741 46583076
Quadriparesis 13.70 10.31 18 101227 1746 46583071
Mucosal erosion 13.65 10.31 16 101229 1382 46583435
Hospitalisation 13.64 10.31 81 101164 63304 46521513
Bradypnoea 13.61 10.31 24 101221 3015 46581802
Osteoporosis 13.54 10.31 44 101201 40564 46544253
Septic shock 13.53 10.31 72 101173 57821 46526996
Coma hepatic 13.53 10.31 11 101234 605 46584212
Decreased activity 13.53 10.31 32 101213 4956 46579861
Haemorrhage 13.52 10.31 67 101178 54802 46530015
Candida infection 13.51 10.31 17 101228 22223 46562594
Amino acid level increased 13.50 10.31 8 101237 262 46584555
Seasonal allergy 13.48 10.31 6 101239 13328 46571489
Glaucoma 13.43 10.31 9 101236 15912 46568905
Gaucher's disease 13.42 10.31 4 101241 20 46584797
Hyperphagia 13.42 10.31 17 101228 1591 46583226
Incoherent 13.40 10.31 30 101215 4482 46580335
Bacteraemia 13.39 10.31 7 101238 14172 46570645
Red blood cell sedimentation rate increased 13.38 10.31 18 101227 22871 46561946
Oral candidiasis 13.38 10.31 11 101234 17521 46567296
Intervertebral disc degeneration 13.34 10.31 6 101239 13246 46571571
Blood pyruvic acid increased 13.34 10.31 3 101242 3 46584814
Asocial behaviour 13.34 10.31 3 101242 3 46584814
Congenital inguinal hernia 13.34 10.31 3 101242 3 46584814
Autonomic nervous system imbalance 13.33 10.31 21 101224 2405 46582412
Gallbladder disorder 13.33 10.31 11 101234 17487 46567330
Electrocardiogram QRS complex shortened 13.30 10.31 9 101236 373 46584444
Parkinsonian gait 13.28 10.31 10 101235 491 46584326
Tooth infection 13.28 10.31 5 101240 12281 46572536
Anaemia macrocytic 13.26 10.31 22 101223 2631 46582186
Intestinal ischaemia 13.24 10.31 39 101206 6886 46577931
Asphyxia 13.20 10.31 33 101212 5293 46579524
Thought blocking 13.18 10.31 6 101239 112 46584705
Rib fracture 13.14 10.31 13 101232 18941 46565876
Glassy eyes 13.14 10.31 5 101240 58 46584759
Hepatic cirrhosis 13.13 10.31 9 101236 15723 46569094
Drug withdrawal syndrome 13.12 10.31 103 101142 27281 46557536
Saccadic eye movement 13.06 10.31 5 101240 59 46584758
Lordosis 13 10.31 8 101237 281 46584536
Blood urea decreased 12.98 10.31 20 101225 2247 46582570
Electrocardiogram abnormal 12.94 10.31 39 101206 6973 46577844
Activated partial thromboplastin time abnormal 12.90 10.31 6 101239 118 46584699
Burning sensation 12.90 10.31 51 101194 44360 46540457
Cortical visual impairment 12.87 10.31 3 101242 4 46584813
Cell death 12.84 10.31 20 101225 2268 46582549
Joint effusion 12.77 10.31 5 101240 11990 46572827
Chorea 12.75 10.31 14 101231 1126 46583691
Injection site warmth 12.71 10.31 7 101238 13765 46571052
Agranulocytosis 12.66 10.31 87 101158 22098 46562719
Skin discolouration 12.65 10.31 33 101212 32647 46552170
Therapeutic product ineffective for unapproved indication 12.65 10.31 7 101238 201 46584616
Erythema multiforme 12.63 10.31 48 101197 9656 46575161
Syncope 12.60 10.31 156 101089 104647 46480170
Breast cancer metastatic 12.56 10.31 7 101238 13671 46571146
Dysphonia 12.55 10.31 42 101203 38372 46546445
Postictal state 12.55 10.31 13 101232 978 46583839
Slow response to stimuli 12.54 10.31 12 101233 820 46583997
Bone disorder 12.50 10.31 15 101230 20018 46564799
Alanine aminotransferase increased 12.49 10.31 265 100980 88186 46496631
Coma acidotic 12.46 10.31 6 101239 128 46584689
Spinal fracture 12.45 10.31 9 101236 15296 46569521
Osteonecrosis 12.44 10.31 23 101222 25721 46559096
Regressive behaviour 12.42 10.31 5 101240 68 46584749
Oedema peripheral 12.41 10.31 258 100987 159448 46425369
Sudden death 12.36 10.31 47 101198 9457 46575360
Electrocardiogram T wave inversion 12.31 10.31 25 101220 3491 46581326
Malignant catatonia 12.29 10.31 4 101241 28 46584789
Dry eye 12.22 10.31 30 101215 30292 46554525
Hernia 12.19 10.31 3 101242 9692 46575125
Metastases to lung 12.17 10.31 4 101241 10692 46574125
Tendonitis 12.14 10.31 8 101237 14269 46570548
School refusal 12.13 10.31 3 101242 6 46584811
Choreoathetosis 12.12 10.31 9 101236 433 46584384
Head deformity 12.10 10.31 5 101240 73 46584744
Systemic inflammatory response syndrome 11.99 10.31 32 101213 5339 46579478
Inhibitory drug interaction 11.99 10.31 18 101227 1977 46582840
Intervertebral disc protrusion 11.98 10.31 16 101229 20389 46564428
Toothache 11.95 10.31 11 101234 16581 46568236
Brachydactyly 11.92 10.31 5 101240 76 46584741
Acute myeloid leukaemia 11.92 10.31 10 101235 15768 46569049
Sinus disorder 11.91 10.31 11 101234 16552 46568265
Homicidal ideation 11.90 10.31 17 101228 1785 46583032
Opisthotonus 11.88 10.31 8 101237 329 46584488
Tachypnoea 11.86 10.31 62 101183 14289 46570528
Alopecia 11.86 10.31 265 100980 162149 46422668
Swelling face 11.84 10.31 67 101178 52992 46531825
Upper limb fracture 11.82 10.31 10 101235 15703 46569114
Anotia 11.81 10.31 3 101242 7 46584810
Lung disorder 11.78 10.31 51 101194 43253 46541564
Rotavirus infection 11.74 10.31 7 101238 232 46584585
Procedural pain 11.74 10.31 7 101238 13172 46571645
Congenital eye disorder 11.72 10.31 4 101241 33 46584784
Nodule 11.65 10.31 10 101235 15595 46569222
Accidental poisoning 11.62 10.31 10 101235 595 46584222
Immunodeficiency 11.62 10.31 7 101238 13099 46571718
Hypoproteinaemia 11.61 10.31 17 101228 1826 46582991
Myoglobinuria 11.58 10.31 7 101238 238 46584579
Neurological decompensation 11.57 10.31 17 101228 1831 46582986
Premature baby 11.53 10.31 73 101172 18039 46566778
Electrocardiogram J wave 11.53 10.31 3 101242 8 46584809
Congenital hypothyroidism 11.53 10.31 7 101238 240 46584577
Drug use disorder 11.48 10.31 21 101224 2714 46582103
Tinnitus 11.45 10.31 27 101218 27646 46557171
Neutrophilia 11.43 10.31 22 101223 2955 46581862
Laboratory test abnormal 11.41 10.31 20 101225 22827 46561990
Blood bicarbonate increased 11.41 10.31 11 101234 759 46584058
Heat stroke 11.38 10.31 10 101235 612 46584205
Colitis ulcerative 11.36 10.31 13 101232 17719 46567098
Viral infection 11.35 10.31 31 101214 30204 46554613
Malignant melanoma 11.34 10.31 4 101241 10230 46574587
Hypoglycaemia neonatal 11.33 10.31 12 101233 926 46583891
Acne 11.31 10.31 16 101229 19903 46564914
Blood osmolarity increased 11.28 10.31 6 101239 159 46584658
Head circumference abnormal 11.27 10.31 3 101242 9 46584808
Blood sodium increased 11.25 10.31 20 101225 2529 46582288
Drug-disease interaction 11.25 10.31 7 101238 251 46584566
Post-anoxic myoclonus 11.22 10.31 4 101241 38 46584779
Maternal exposure during breast feeding 11.19 10.31 21 101224 2768 46582049
Acidosis 11.19 10.31 51 101194 11123 46573694
Delusion of reference 11.15 10.31 5 101240 90 46584727
Faecal vomiting 11.15 10.31 10 101235 629 46584188
Eosinophilic myocarditis 11.14 10.31 8 101237 365 46584452
Histiocytic necrotising lymphadenitis 11.13 10.31 4 101241 39 46584778
Infusion site pain 11.12 10.31 4 101241 10103 46574714
Posturing 11.12 10.31 9 101236 492 46584325
Tooth disorder 11.10 10.31 21 101224 23282 46561535
Lactation disorder 11.03 10.31 7 101238 260 46584557
Hepatomegaly 11.00 10.31 51 101194 11202 46573615
Increased appetite 10.95 10.31 42 101203 8485 46576332
Joint range of motion decreased 10.92 10.31 10 101235 15114 46569703
Congenital nail disorder 10.91 10.31 5 101240 95 46584722
Oppositional defiant disorder 10.87 10.31 4 101241 42 46584775
Neurogenic bowel 10.86 10.31 5 101240 96 46584721
Neonatal hypotension 10.86 10.31 5 101240 96 46584721
Poverty of speech 10.86 10.31 7 101238 267 46584550
Musculoskeletal chest pain 10.83 10.31 14 101231 18092 46566725
Hydrocephalus 10.83 10.31 29 101216 4848 46579969
Anaphylactic shock 10.82 10.31 17 101228 20257 46564560
Cleft uvula 10.81 10.31 3 101242 11 46584806
Melaena 10.79 10.31 28 101217 27744 46557073
Encapsulating peritoneal sclerosis 10.79 10.31 8 101237 384 46584433
Idiosyncratic drug reaction 10.75 10.31 11 101234 816 46584001
Antidepressant drug level increased 10.74 10.31 7 101238 272 46584545
Amniocentesis abnormal 10.72 10.31 5 101240 99 46584718
Aura 10.71 10.31 12 101233 987 46583830
Procalcitonin increased 10.69 10.31 10 101235 664 46584153
Thyroglobulin increased 10.62 10.31 4 101241 45 46584772
Acid-base balance disorder mixed 10.61 10.31 3 101242 12 46584805
Eye swelling 10.59 10.31 17 101228 20086 46564731
Cerebral disorder 10.57 10.31 23 101222 3371 46581446
Persistent left superior vena cava 10.54 10.31 4 101241 46 46584771
Gastroenteritis 10.53 10.31 23 101222 24196 46560621
Rotator cuff syndrome 10.53 10.31 6 101239 11577 46573240
Delusional disorder, unspecified type 10.52 10.31 8 101237 399 46584418
Maternal drugs affecting foetus 10.48 10.31 31 101214 5487 46579330
Amimia 10.46 10.31 4 101241 47 46584770
Heterophoria 10.41 10.31 3 101242 13 46584804
Scar excision 10.39 10.31 4 101241 48 46584769
Ageusia 10.35 10.31 6 101239 11466 46573351
Soliloquy 10.34 10.31 6 101239 189 46584628
Xanthoma 10.31 10.31 4 101241 49 46584768
Body height decreased 10.31 10.31 4 101241 9648 46575169

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1724.83 11.08 1950 106958 96525 29747045
Hyperammonaemia 1048.94 11.08 475 108433 5045 29838525
Foetal anticonvulsant syndrome 897.28 11.08 255 108653 519 29843051
Epilepsy 756.90 11.08 610 108298 19559 29824011
Neuroleptic malignant syndrome 713.62 11.08 540 108368 15755 29827815
Aggression 707.82 11.08 768 108140 36139 29807431
Hyperammonaemic encephalopathy 676.15 11.08 254 108654 1590 29841980
Dysmorphism 675.35 11.08 260 108648 1757 29841813
Drug interaction 651.19 11.08 1890 107018 197678 29645892
Status epilepticus 624.66 11.08 428 108480 10644 29832926
Somnolence 462.08 11.08 1059 107849 95704 29747866
Autism spectrum disorder 458.64 11.08 175 108733 1150 29842420
Foetal exposure during pregnancy 446.31 11.08 608 108300 36263 29807307
Mania 399.84 11.08 303 108605 8851 29834719
Ammonia increased 377.70 11.08 219 108689 4022 29839548
Generalised tonic-clonic seizure 376.53 11.08 408 108500 19143 29824427
Abnormal behaviour 374.75 11.08 464 108444 25159 29818411
Dyspnoea 354.00 11.08 416 108492 332879 29510691
Speech disorder developmental 352.42 11.08 140 108768 1039 29842531
Agitation 341.74 11.08 664 108244 53409 29790161
Psychotic disorder 333.07 11.08 401 108507 21114 29822456
Granulocytopenia 333.06 11.08 233 108675 5993 29837577
Sedation 331.69 11.08 351 108557 16022 29827548
Parkinsonism 309.51 11.08 237 108671 7032 29836538
Diarrhoea 302.02 11.08 469 108439 333634 29509936
Developmental delay 292.80 11.08 147 108761 1994 29841576
Extrapyramidal disorder 286.57 11.08 267 108641 10426 29833144
Sopor 274.62 11.08 264 108644 10727 29832843
Learning disorder 247.76 11.08 85 108823 391 29843179
Intellectual disability 238.31 11.08 96 108812 742 29842828
Psychomotor retardation 236.45 11.08 132 108776 2247 29841323
Death 236.31 11.08 602 108306 356681 29486889
Febrile neutropenia 236.02 11.08 50 108858 106643 29736927
Coma 231.81 11.08 477 108431 39972 29803598
Schizophrenia 231.10 11.08 220 108688 8828 29834742
Cognitive disorder 228.56 11.08 351 108557 23339 29820231
Congenital nose malformation 224.37 11.08 63 108845 120 29843450
Arthralgia 217.75 11.08 111 108797 135680 29707890
Drug level decreased 205.86 11.08 170 108738 5635 29837935
Acute kidney injury 202.76 11.08 434 108474 273408 29570162
Antipsychotic drug level increased 201.59 11.08 132 108776 3034 29840536
Fatigue 201.45 11.08 554 108354 320119 29523451
Attention deficit hyperactivity disorder 200.02 11.08 108 108800 1716 29841854
Irritability 199.54 11.08 325 108583 22725 29820845
Petit mal epilepsy 198.21 11.08 122 108786 2509 29841061
Myocardial infarction 197.97 11.08 105 108803 125520 29718050
Salivary hypersecretion 197.11 11.08 186 108722 7380 29836190
Toxicity to various agents 195.22 11.08 1205 107703 175978 29667592
Intentional self-injury 192.88 11.08 242 108666 13290 29830280
Nausea 190.23 11.08 508 108400 296449 29547121
Intentional overdose 187.69 11.08 445 108463 41036 29802534
Pain 177.83 11.08 220 108688 172421 29671149
Psychomotor hyperactivity 176.71 11.08 182 108726 8042 29835528
Anaemia 174.33 11.08 306 108602 207686 29635884
Tremor 174.13 11.08 636 108272 74727 29768843
Cardiac failure congestive 170.16 11.08 48 108860 84359 29759211
Ataxia 169.80 11.08 209 108699 11253 29832317
Mental impairment 167.11 11.08 187 108721 9090 29834480
Atrial fibrillation 166.49 11.08 93 108815 108031 29735539
Blood creatine phosphokinase increased 164.43 11.08 438 108470 43410 29800160
Drug level increased 163.22 11.08 262 108646 18092 29825478
Overdose 160.13 11.08 669 108239 83668 29759902
Disturbance in attention 157.36 11.08 286 108622 21843 29821727
Speech disorder 155.89 11.08 302 108606 24210 29819360
Plasma cell myeloma 154.87 11.08 10 108898 53452 29790118
Language disorder 154.60 11.08 81 108827 1207 29842363
Hypospadias 154.43 11.08 105 108803 2574 29840996
Anticonvulsant drug level increased 153.13 11.08 85 108823 1430 29842140
Delusion 148.39 11.08 200 108708 11789 29831781
Hallucination, auditory 147.43 11.08 180 108728 9609 29833961
Catatonia 146.47 11.08 124 108784 4256 29839314
Gastrointestinal haemorrhage 146.44 11.08 60 108848 83386 29760184
Product residue present 145.03 11.08 101 108807 2577 29840993
Electroencephalogram abnormal 143.92 11.08 96 108812 2278 29841292
Dystonia 143.49 11.08 177 108731 9550 29834020
Partial seizures 143.44 11.08 115 108793 3652 29839918
Product substitution issue 139.09 11.08 177 108731 9858 29833712
Pain in extremity 138.86 11.08 118 108790 110103 29733467
Neuropathy peripheral 138.50 11.08 42 108866 70433 29773137
Suicide attempt 138.00 11.08 367 108541 36330 29807240
Pneumonia 137.83 11.08 687 108221 333619 29509951
Muscle rigidity 135.97 11.08 177 108731 10084 29833486
Anticonvulsant drug level decreased 130.69 11.08 67 108841 952 29842618
Tardive dyskinesia 129.20 11.08 123 108785 4934 29838636
Depressed level of consciousness 125.69 11.08 364 108544 37858 29805712
Dyskinesia 123.26 11.08 256 108652 21578 29821992
Drug reaction with eosinophilia and systemic symptoms 122.78 11.08 300 108608 28188 29815382
Bipolar disorder 122.38 11.08 105 108803 3671 29839899
Psychomotor skills impaired 122.32 11.08 81 108827 1898 29841672
Akathisia 122.06 11.08 128 108780 5776 29837794
Dysgraphia 120.46 11.08 73 108835 1458 29842112
Motor developmental delay 117.36 11.08 45 108863 300 29843270
Congenital oral malformation 117.31 11.08 26 108882 3 29843567
Myocarditis 116.34 11.08 162 108746 9849 29833721
Encephalopathy 115.98 11.08 317 108591 31888 29811682
Antipsychotic drug level below therapeutic 114.65 11.08 68 108840 1304 29842266
Interstitial lung disease 114.49 11.08 38 108870 60159 29783411
Disease progression 114.10 11.08 75 108833 79799 29763771
Priapism 112.97 11.08 111 108797 4632 29838938
Asthenia 111.60 11.08 421 108487 220869 29622701
Malignant neoplasm progression 111.47 11.08 62 108846 72225 29771345
Schizoaffective disorder 111.33 11.08 61 108847 999 29842571
Multiple-drug resistance 110.31 11.08 89 108819 2852 29840718
Treatment noncompliance 109.96 11.08 267 108641 24986 29818584
Lip disorder 108.13 11.08 44 108864 350 29843220
Renal failure 104.94 11.08 193 108715 128773 29714797
Astigmatism 104.70 11.08 53 108855 732 29842838
Skull malformation 104.21 11.08 42 108866 325 29843245
Neurodevelopmental disorder 104.08 11.08 34 108874 130 29843440
Paranoia 103.96 11.08 155 108753 10033 29833537
Delirium 103.28 11.08 354 108554 40277 29803293
Sudden unexplained death in epilepsy 102.48 11.08 44 108864 406 29843164
Mental disorder 102.25 11.08 179 108729 13270 29830300
Hypotonia neonatal 102.00 11.08 57 108851 972 29842598
Dysarthria 101.81 11.08 292 108616 30198 29813372
Hypotonia 101.78 11.08 126 108782 6822 29836748
Focal dyscognitive seizures 101.75 11.08 62 108846 1251 29842319
Joint swelling 101.70 11.08 23 108885 46923 29796647
Restlessness 101.68 11.08 242 108666 22357 29821213
Back pain 101.09 11.08 135 108773 102461 29741109
Dyspraxia 99.91 11.08 37 108871 221 29843349
Cough 99.60 11.08 191 108717 125451 29718119
Chest pain 99.32 11.08 172 108736 117455 29726115
Bradyphrenia 98.73 11.08 95 108813 3862 29839708
Euphoric mood 97.73 11.08 98 108810 4192 29839378
Peripheral swelling 97.66 11.08 50 108858 61024 29782546
Low set ears 94.97 11.08 41 108867 384 29843186
Infusion related reaction 93.84 11.08 17 108891 40547 29803023
Depression 93.65 11.08 606 108302 89831 29753739
Altered state of consciousness 93.64 11.08 217 108691 19702 29823868
Coronary artery disease 93.45 11.08 32 108876 49680 29793890
Thrombosis 92.87 11.08 20 108888 42211 29801359
Wrong patient received product 92.53 11.08 66 108842 1751 29841819
Thinking abnormal 92.14 11.08 105 108803 5206 29838364
Enuresis 91.63 11.08 65 108843 1709 29841861
Anticonvulsant drug level below therapeutic 89.84 11.08 45 108863 607 29842963
Fanconi syndrome 89.30 11.08 64 108844 1711 29841859
Myoclonic epilepsy 88.04 11.08 48 108860 778 29842792
Antipsychotic drug level above therapeutic 86.72 11.08 52 108856 1018 29842552
Foot deformity 86.67 11.08 83 108825 3354 29840216
Pruritus 86.61 11.08 188 108720 118016 29725554
Suicidal ideation 86.03 11.08 308 108600 35806 29807764
Cryptorchism 85.59 11.08 61 108847 1616 29841954
Myalgia 84.94 11.08 92 108816 76575 29766995
Learning disability 84.42 11.08 29 108879 134 29843436
Drooling 84.30 11.08 77 108831 2928 29840642
Drug level below therapeutic 83.81 11.08 81 108827 3311 29840259
Psoriasis 82.29 11.08 26 108882 42480 29801090
Prominent epicanthal folds 81.75 11.08 28 108880 128 29843442
Acute myocardial infarction 80.74 11.08 46 108862 52893 29790677
Abdominal pain 80.65 11.08 240 108668 135414 29708156
Behaviour disorder 80.06 11.08 68 108840 2344 29841226
Pectus excavatum 79.94 11.08 24 108884 64 29843506
Hypernatraemia 79.44 11.08 116 108792 7368 29836202
Myopia 78.35 11.08 40 108868 563 29843007
Oedema peripheral 77.79 11.08 168 108740 105664 29737906
Oppositional defiant disorder 77.62 11.08 35 108873 367 29843203
Coordination abnormal 77.21 11.08 113 108795 7192 29836378
Hyperkalaemia 76.74 11.08 76 108832 65934 29777636
Hypothermia 76.21 11.08 130 108778 9437 29834133
Obsessive-compulsive disorder 75.47 11.08 84 108824 4057 29839513
Drug withdrawal convulsions 75.44 11.08 49 108859 1110 29842460
Myoclonus 75.02 11.08 156 108752 13156 29830414
Disorientation 74.87 11.08 268 108640 31150 29812420
Neutrophil count increased 74.31 11.08 169 108739 15154 29828416
Congenital anomaly 74.27 11.08 51 108857 1271 29842299
Asterixis 74.13 11.08 50 108858 1209 29842361
Cardiac failure 74.07 11.08 118 108790 83300 29760270
Headache 74.06 11.08 376 108532 181930 29661640
Dyspnoea exertional 73.51 11.08 19 108889 35411 29808159
Antipsychotic drug level decreased 72.47 11.08 43 108865 825 29842745
Congenital foot malformation 72.39 11.08 27 108881 165 29843405
Talipes 72.14 11.08 55 108853 1620 29841950
Dizziness 71.47 11.08 416 108492 194493 29649077
Sepsis 71.43 11.08 282 108626 146113 29697457
Bipolar I disorder 69.97 11.08 41 108867 768 29842802
Hypomania 69.61 11.08 61 108847 2195 29841375
Pneumonia aspiration 68.72 11.08 296 108612 37484 29806086
White blood cell count increased 68.49 11.08 306 108602 39367 29804203
Clinodactyly 68.33 11.08 24 108884 120 29843450
Anticonvulsant drug level above therapeutic 68.30 11.08 32 108876 369 29843201
Joint laxity 68.15 11.08 21 108887 63 29843507
Limb malformation 67.69 11.08 30 108878 301 29843269
Developmental coordination disorder 67.59 11.08 18 108890 25 29843545
Psychogenic seizure 67.51 11.08 29 108879 268 29843302
Chills 67.41 11.08 99 108809 72239 29771331
Infantile spasms 67.32 11.08 29 108879 270 29843300
Chest discomfort 67.26 11.08 41 108867 45439 29798131
Stevens-Johnson syndrome 66.39 11.08 176 108732 17380 29826190
Eosinophilia 66.15 11.08 204 108704 21956 29821614
Strabismus 66.04 11.08 45 108863 1107 29842463
Oculogyric crisis 65.58 11.08 48 108860 1327 29842243
Persecutory delusion 64.30 11.08 57 108851 2083 29841487
Mucosal inflammation 63.95 11.08 16 108892 30478 29813092
Renal impairment 63.21 11.08 132 108776 84052 29759518
Fine motor delay 62.87 11.08 23 108885 132 29843438
Disturbance in social behaviour 62.69 11.08 48 108860 1423 29842147
Obesity 62.62 11.08 112 108796 8443 29835127
Affect lability 61.72 11.08 69 108839 3349 29840221
Ligament laxity 61.68 11.08 15 108893 10 29843560
Confusional state 61.58 11.08 755 108153 134079 29709491
Cerebrovascular accident 60.92 11.08 133 108775 83344 29760226
Pulmonary embolism 60.80 11.08 120 108788 78015 29765555
Completed suicide 60.60 11.08 590 108318 98902 29744668
Hypertonia 60.22 11.08 77 108831 4308 29839262
Anger 58.83 11.08 127 108781 10993 29832577
Exposure during pregnancy 58.73 11.08 114 108794 9147 29834423
Congenital hand malformation 57.91 11.08 30 108878 436 29843134
Dehydration 57.71 11.08 242 108666 123297 29720273
Prostate cancer 57.71 11.08 9 108899 23948 29819622
Communication disorder 57.13 11.08 54 108854 2146 29841424
Atonic seizures 56.96 11.08 22 108886 150 29843420
Decreased eye contact 56.94 11.08 29 108879 406 29843164
Pressure of speech 56.50 11.08 29 108879 413 29843157
Influenza 56.40 11.08 45 108863 43353 29800217
Musculoskeletal pain 56.29 11.08 21 108887 30919 29812651
Epistaxis 56.02 11.08 66 108842 52915 29790655
Asocial behaviour 55.67 11.08 17 108891 49 29843521
Increased appetite 55.23 11.08 84 108824 5533 29838037
Hypermetropia 55.20 11.08 24 108884 229 29843341
Blood pressure increased 54.65 11.08 112 108796 71816 29771754
Nystagmus 54.64 11.08 73 108835 4265 29839305
Ear malformation 54.57 11.08 24 108884 236 29843334
Differential white blood cell count abnormal 54.36 11.08 42 108866 1262 29842308
Angina pectoris 53.76 11.08 20 108888 29498 29814072
Microcephaly 53.66 11.08 32 108876 620 29842950
Weight increased 53.07 11.08 459 108449 74454 29769116
Craniosynostosis 52.94 11.08 23 108885 219 29843351
Disinhibition 52.67 11.08 49 108859 1908 29841662
Fluid retention 52.64 11.08 13 108895 24985 29818585
Physical assault 52.61 11.08 40 108868 1173 29842397
Urticaria 52.58 11.08 73 108835 54533 29789037
Ascites 52.26 11.08 33 108875 35888 29807682
Congenital eye disorder 52.17 11.08 16 108892 47 29843523
Upper gastrointestinal haemorrhage 51.44 11.08 9 108899 22019 29821551
Mental status changes 51.03 11.08 268 108640 36811 29806759
Muscle spasms 50.94 11.08 99 108809 64739 29778831
Drug level changed 50.72 11.08 25 108883 325 29843245
Blood creatinine increased 50.49 11.08 167 108741 91208 29752362
Osteonecrosis of jaw 49.69 11.08 5 108903 18613 29824957
Brain oedema 49.65 11.08 127 108781 12271 29831299
Homicidal ideation 48.43 11.08 52 108856 2411 29841159
Hypersensitivity 48.34 11.08 76 108832 53952 29789618
Melaena 48.29 11.08 29 108879 32408 29811162
Atrial septal defect 48.11 11.08 87 108821 6614 29836956
Bradykinesia 47.99 11.08 59 108849 3171 29840399
Normal pressure hydrocephalus 47.94 11.08 19 108889 140 29843430
Prescribed overdose 47.86 11.08 100 108808 8461 29835109
Personality disorder 47.71 11.08 37 108871 1118 29842452
Eosinophilic pleural effusion 47.70 11.08 21 108887 207 29843363
Drug ineffective 47.32 11.08 1593 107315 338794 29504776
Serotonin syndrome 47.30 11.08 158 108750 17733 29825837
Stupor 47.24 11.08 56 108852 2897 29840673
Abdominal pain upper 47.01 11.08 98 108810 62453 29781117
Dysphoria 46.98 11.08 48 108860 2100 29841470
Impulsive behaviour 46.82 11.08 46 108862 1919 29841651
Sinusitis 46.65 11.08 32 108876 33313 29810257
Congenital hair disorder 46.21 11.08 10 108898 0 29843570
Hyperosmolar state 46.19 11.08 25 108883 399 29843171
Hypermobility syndrome 46.17 11.08 21 108887 225 29843345
Lethargy 45.98 11.08 273 108635 39246 29804324
Septic shock 45.85 11.08 102 108806 63505 29780065
Gait disturbance 45.78 11.08 444 108464 74333 29769237
Toxic encephalopathy 45.42 11.08 69 108839 4540 29839030
High arched palate 45.34 11.08 12 108896 16 29843554
Pancytopenia 44.58 11.08 159 108749 84893 29758677
Educational problem 43.90 11.08 22 108886 297 29843273
Weight decreased 43.83 11.08 345 108563 150576 29692994
Diabetes insipidus 43.55 11.08 47 108861 2192 29841378
Echolalia 43.19 11.08 19 108889 187 29843383
Cytomegalovirus infection 43.18 11.08 16 108892 23658 29819912
Syncope 43 11.08 161 108747 84742 29758828
Blood prolactin increased 42.97 11.08 38 108870 1384 29842186
Herpes zoster 42.88 11.08 28 108880 29915 29813655
Acidosis hyperchloraemic 42.88 11.08 21 108887 269 29843301
Postictal paralysis 42.69 11.08 17 108891 127 29843443
Erythema 42.48 11.08 142 108766 77309 29766261
Bruxism 42.44 11.08 37 108871 1322 29842248
Spina bifida 42.39 11.08 22 108886 321 29843249
Hyperprolactinaemia 42.24 11.08 35 108873 1165 29842405
Arnold-Chiari malformation 41.84 11.08 20 108888 242 29843328
Leukopenia 41.82 11.08 348 108560 55811 29787759
Congenital eyelid malformation 41.70 11.08 13 108895 41 29843529
Urinary incontinence 41.63 11.08 146 108762 16794 29826776
Chronic kidney disease 41.22 11.08 46 108862 37792 29805778
Seizure cluster 41.19 11.08 16 108892 111 29843459
Nose deformity 40.35 11.08 17 108891 149 29843421
Anaphylactic reaction 40.30 11.08 26 108882 27956 29815614
Homicide 39.96 11.08 32 108876 1014 29842556
Dyslexia 39.96 11.08 17 108891 153 29843417
Rectal haemorrhage 39.71 11.08 41 108867 34898 29808672
Arthropathy 39.54 11.08 13 108895 20714 29822856
Multiple congenital abnormalities 39.27 11.08 24 108884 487 29843083
Hypoaesthesia 39.05 11.08 87 108821 54143 29789427
Hyperkinesia 39.00 11.08 43 108865 2055 29841515
Arthritis 38.95 11.08 20 108888 24381 29819189
Choreoathetosis 38.50 11.08 30 108878 913 29842657
Psychiatric symptom 38.24 11.08 54 108854 3325 29840245
Haemoptysis 38.19 11.08 34 108874 31044 29812526
Scoliosis 38.11 11.08 38 108870 1614 29841956
Ear disorder 37.98 11.08 29 108879 856 29842714
Sleep disorder 37.95 11.08 183 108725 24296 29819274
Hyperacusis 37.93 11.08 25 108883 581 29842989
Respiratory failure 37.78 11.08 213 108695 100429 29743141
Cerebral atrophy 37.65 11.08 62 108846 4371 29839199
Logorrhoea 37.54 11.08 42 108866 2040 29841530
Palmar-plantar erythrodysaesthesia syndrome 37.18 11.08 5 108903 14865 29828705
Affective disorder 37.16 11.08 51 108857 3057 29840513
Eosinophil count decreased 37.14 11.08 32 108876 1125 29842445
Carnitine decreased 36.96 11.08 8 108900 0 29843570
Swelling 36.77 11.08 46 108862 35929 29807641
Postictal psychosis 36.68 11.08 14 108894 92 29843478
Motor dysfunction 36.63 11.08 72 108836 5830 29837740
Basal cell carcinoma 36.58 11.08 7 108901 16061 29827509
Nasopharyngitis 36.46 11.08 102 108806 58747 29784823
Pneumonitis 36.25 11.08 28 108880 27426 29816144
Delusional disorder, unspecified type 36.25 11.08 27 108881 767 29842803
Apathy 36.25 11.08 74 108834 6158 29837412
General physical health deterioration 36.18 11.08 214 108694 99730 29743840
Pneumocystis jirovecii pneumonia 35.86 11.08 9 108899 17111 29826459
Tumour lysis syndrome 35.61 11.08 3 108905 12882 29830688
Psoriatic arthropathy 35.60 11.08 7 108901 15754 29827816
Full blood count decreased 35.46 11.08 7 108901 15710 29827860
Faecaloma 35.27 11.08 60 108848 4345 29839225
Rash 35.10 11.08 489 108419 191400 29652170
Cerebellar atrophy 34.89 11.08 21 108887 414 29843156
Chorea 34.67 11.08 30 108878 1061 29842509
Lung disorder 34.56 11.08 38 108870 31431 29812139
Paraesthesia 34.53 11.08 93 108815 54234 29789336
Plagiocephaly 34.47 11.08 19 108889 315 29843255
Illiteracy 34.43 11.08 8 108900 3 29843567
Coloboma 34.42 11.08 15 108893 144 29843426
Psychotic symptom 34.40 11.08 31 108877 1158 29842412
Pancreatitis 34.39 11.08 239 108669 36251 29807319
Gastrointestinal malformation 34.31 11.08 11 108897 39 29843531
Pleurothotonus 34.28 11.08 29 108879 994 29842576
Colitis 34.09 11.08 37 108871 30783 29812787
Therapeutic product effect variable 34.00 11.08 33 108875 1356 29842214
Eosinophil count increased 33.57 11.08 80 108828 7393 29836177
Flight of ideas 33.29 11.08 19 108889 338 29843232
Malaise 33.26 11.08 418 108490 166544 29677026
Neoplasm progression 33.17 11.08 12 108896 18011 29825559
Dysgeusia 33.12 11.08 25 108883 24776 29818794
Acute myeloid leukaemia 33.12 11.08 12 108896 17994 29825576
Congenital musculoskeletal anomaly 33.01 11.08 16 108892 200 29843370
Sedation complication 32.90 11.08 26 108882 808 29842762
Dysmetria 32.90 11.08 19 108889 346 29843224
Pancreatitis acute 32.83 11.08 182 108726 25513 29818057
Stomatitis 32.81 11.08 53 108855 37226 29806344
Delusion of grandeur 32.75 11.08 19 108889 349 29843221
Nasal septum disorder 32.71 11.08 11 108897 47 29843523
Anisometropia 32.71 11.08 11 108897 47 29843523
Congenital nail disorder 32.70 11.08 10 108898 29 29843541
Haematochezia 32.69 11.08 46 108862 34176 29809394
Medication error 32.67 11.08 157 108751 20815 29822755
Soliloquy 32.51 11.08 19 108889 354 29843216
Arachnodactyly 32.51 11.08 8 108900 6 29843564
Coma scale abnormal 32.50 11.08 50 108858 3326 29840244
Autonomic nervous system imbalance 32.44 11.08 42 108866 2379 29841191
Perseveration 32.43 11.08 13 108895 99 29843471
Anion gap increased 32.19 11.08 35 108873 1646 29841924
Retinal coloboma 32.10 11.08 9 108899 17 29843553
Crying 31.91 11.08 66 108842 5543 29838027
Drop attacks 31.87 11.08 22 108886 553 29843017
Necrosis ischaemic 31.54 11.08 16 108892 222 29843348
Mood altered 31.48 11.08 83 108825 8167 29835403
Abdominal discomfort 31.40 11.08 83 108825 48708 29794862
Angular cheilitis 31.36 11.08 13 108895 109 29843461
Convulsive threshold lowered 31.12 11.08 21 108887 508 29843062
Nipple disorder 30.92 11.08 15 108893 188 29843382
Haemorrhage 30.72 11.08 77 108831 46002 29797568
Haematuria 30.61 11.08 74 108834 44760 29798810
Confabulation 30.46 11.08 13 108895 118 29843452
Transient ischaemic attack 30.45 11.08 28 108880 25172 29818398
Stereotypy 30.45 11.08 21 108887 527 29843043
Inappropriate antidiuretic hormone secretion 30.30 11.08 101 108807 11321 29832249
Monocyte count increased 30.13 11.08 50 108858 3548 29840022
Oedema 30.12 11.08 70 108838 42923 29800647
Postictal state 30.00 11.08 23 108885 683 29842887
Deep vein thrombosis 29.80 11.08 116 108792 60385 29783185
Distractibility 29.51 11.08 17 108891 308 29843262
International normalised ratio increased 29.38 11.08 83 108825 47656 29795914
Lymphocyte count increased 29.33 11.08 41 108867 2501 29841069
Inappropriate affect 29.31 11.08 21 108887 561 29843009
Angioedema 29.22 11.08 50 108858 34334 29809236
Anticonvulsant drug level abnormal 29.21 11.08 9 108899 27 29843543
Scaphocephaly 28.92 11.08 8 108900 14 29843556
Angina unstable 28.81 11.08 5 108903 12305 29831265
Renal disorder 28.74 11.08 26 108882 23558 29820012
Dyscalculia 28.57 11.08 8 108900 15 29843555
Congenital myopia 28.57 11.08 8 108900 15 29843555
Chronic obstructive pulmonary disease 28.53 11.08 80 108828 46046 29797524
Brugada syndrome 28.49 11.08 21 108887 587 29842983
Social avoidant behaviour 28.41 11.08 43 108865 2820 29840750
Bone pain 28.33 11.08 17 108891 19009 29824561
Anaphylactic shock 28.09 11.08 8 108900 13985 29829585
Metabolic syndrome 27.95 11.08 31 108877 1491 29842079
Knee deformity 27.94 11.08 17 108891 342 29843228
Osteoarthritis 27.88 11.08 16 108892 18333 29825237
Neural tube defect 27.84 11.08 9 108899 33 29843537
Meningocele 27.84 11.08 9 108899 33 29843537
Cogwheel rigidity 27.82 11.08 27 108881 1109 29842461
Flushing 27.81 11.08 40 108868 29452 29814118
Pneumothorax 27.80 11.08 12 108896 16181 29827389
Metabolic acidosis 27.80 11.08 232 108676 37229 29806341
Diabetic hyperosmolar coma 27.68 11.08 17 108891 348 29843222
Bacteraemia 27.57 11.08 11 108897 15549 29828021
Drug level above therapeutic 27.56 11.08 43 108865 2896 29840674
Hypokalaemia 27.52 11.08 92 108816 50100 29793470
Intentional product use issue 27.44 11.08 57 108851 36383 29807187
Cerebral ventricle dilatation 27.42 11.08 23 108885 779 29842791
Congenital astigmatism 27.30 11.08 8 108900 19 29843551
Atrial flutter 27.16 11.08 9 108899 14272 29829298
Fluid overload 27.14 11.08 18 108890 19074 29824496
Acute coronary syndrome 26.80 11.08 8 108900 13565 29830005
Bronchopulmonary aspergillosis 26.63 11.08 6 108902 12278 29831292
Gaze palsy 26.20 11.08 26 108882 1098 29842472
Condition aggravated 26.08 11.08 671 108237 137195 29706375
Unresponsive to stimuli 26.06 11.08 175 108733 26244 29817326
Emotional disorder of childhood 25.96 11.08 8 108900 24 29843546
Bicuspid aortic valve 25.95 11.08 14 108894 222 29843348
Muscle tone disorder 25.79 11.08 10 108898 69 29843501
Retrognathia 25.73 11.08 14 108894 226 29843344
Cytokine release syndrome 25.66 11.08 3 108905 9930 29833640
Staphylococcal infection 25.64 11.08 44 108864 30180 29813390
Duodenal ulcer 25.55 11.08 3 108905 9898 29833672
Laboratory test abnormal 25.40 11.08 16 108892 17426 29826144
Choroidal coloboma 25.30 11.08 6 108902 3 29843567
Decreased appetite 25.30 11.08 388 108520 149522 29694048
Brain malformation 25.08 11.08 10 108898 75 29843495
Staring 25.02 11.08 29 108879 1464 29842106
Water intoxication 25.02 11.08 18 108890 484 29843086
Myelodysplastic syndrome 24.99 11.08 19 108889 18759 29824811
Renal injury 24.89 11.08 6 108902 11723 29831847
Tachycardia 24.71 11.08 391 108517 73348 29770222
Night sweats 24.57 11.08 11 108897 14517 29829053
Basilar artery occlusion 24.52 11.08 10 108898 80 29843490
Emotional disorder 24.49 11.08 56 108852 5038 29838532
Circadian rhythm sleep disorder 24.42 11.08 16 108892 368 29843202
Intelligence test abnormal 24.38 11.08 7 108901 15 29843555
Hypotension 24.25 11.08 550 108358 200015 29643555
Device related infection 24.24 11.08 16 108892 16999 29826571
Judgement impaired 24.21 11.08 20 108888 663 29842907
Anxiety 24.16 11.08 460 108448 89411 29754159
Movement disorder 24.13 11.08 85 108823 9798 29833772
Sluggishness 24.10 11.08 42 108866 3101 29840469
Haemoglobin decreased 24.08 11.08 282 108626 113816 29729754
Nephrolithiasis 24.04 11.08 33 108875 24777 29818793
Injection site pain 24.04 11.08 46 108862 30264 29813306
Aminoaciduria 24.01 11.08 11 108897 120 29843450
Rhinorrhoea 23.98 11.08 24 108884 20730 29822840
Pulmonary fibrosis 23.94 11.08 14 108894 15876 29827694
COVID-19 23.90 11.08 18 108890 17860 29825710
Tonic clonic movements 23.86 11.08 24 108884 1030 29842540
Dacryostenosis congenital 23.78 11.08 7 108901 17 29843553
Food interaction 23.72 11.08 22 108886 853 29842717
Fine motor skill dysfunction 23.69 11.08 25 108883 1136 29842434
Antisocial behaviour 23.67 11.08 14 108894 267 29843303
Camptodactyly congenital 23.64 11.08 8 108900 35 29843535
Grandiosity 23.56 11.08 15 108893 328 29843242
Nasal disorder 23.51 11.08 25 108883 1146 29842424
Mood swings 23.49 11.08 71 108837 7555 29836015
Torticollis 23.47 11.08 24 108884 1051 29842519
Energy increased 23.45 11.08 26 108882 1250 29842320
Blood triglycerides increased 23.34 11.08 107 108801 13910 29829660
Blood potassium decreased 23.29 11.08 16 108892 16646 29826924
Phobia 23.22 11.08 10 108898 93 29843477
Visuospatial deficit 23.11 11.08 6 108902 7 29843563
Hypotelorism of orbit 23.04 11.08 10 108898 95 29843475
Apraxia 22.97 11.08 25 108883 1177 29842393
Incoherent 22.90 11.08 48 108860 4070 29839500
Cellulitis 22.84 11.08 90 108818 46694 29796876
Synovitis 22.84 11.08 4 108904 9779 29833791
Mutism 22.72 11.08 20 108888 724 29842846
Acute hepatic failure 22.53 11.08 94 108814 11733 29831837
Heart rate decreased 22.34 11.08 26 108882 20968 29822602
Tonic convulsion 22.27 11.08 21 108887 832 29842738
Salivary gland enlargement 22.24 11.08 7 108901 23 29843547
Osteomyelitis 22.03 11.08 13 108895 14668 29828902
Depressed mood 22.00 11.08 121 108787 16908 29826662
Metastases to liver 21.96 11.08 8 108900 11957 29831613
Cleft palate 21.96 11.08 18 108890 590 29842980
Type 2 diabetes mellitus 21.96 11.08 103 108805 13519 29830051
Intensive care unit acquired weakness 21.88 11.08 21 108887 851 29842719
Negativism 21.80 11.08 15 108893 375 29843195
Patient isolation 21.80 11.08 7 108901 25 29843545
Mucosal ulceration 21.75 11.08 21 108887 857 29842713
Post-injection delirium sedation syndrome 21.70 11.08 15 108893 378 29843192
Febrile convulsion 21.65 11.08 16 108892 449 29843121
Drug intolerance 21.56 11.08 88 108820 45203 29798367
Toxic epidermal necrolysis 21.55 11.08 125 108783 17815 29825755
Infection 21.47 11.08 181 108727 77893 29765677
Patent ductus arteriosus 21.31 11.08 40 108868 3129 29840441
Hyponatraemia 21.26 11.08 353 108555 66849 29776721
Rhabdomyolysis 21.24 11.08 337 108571 63243 29780327
Choking 21.20 11.08 52 108856 4894 29838676
Subacute endocarditis 21.17 11.08 8 108900 51 29843519
Peritonitis 21.15 11.08 28 108880 21347 29822223
Cerebral haemorrhage 21.11 11.08 56 108852 32831 29810739
Product dose omission issue 21.10 11.08 222 108686 91409 29752161
Intestinal ischaemia 21.05 11.08 64 108844 6833 29836737
Memory impairment 20.92 11.08 217 108691 36957 29806613
Blood bilirubin increased 20.88 11.08 66 108842 36570 29807000
Oligoasthenozoospermia 20.85 11.08 6 108902 13 29843557
Prognathism 20.85 11.08 6 108902 13 29843557
Renal tubular necrosis 20.85 11.08 15 108893 15236 29828334
Cerebral palsy 20.78 11.08 9 108899 85 29843485
Gastric volvulus 20.76 11.08 5 108903 3 29843567
Lacrimal gland enlargement 20.76 11.08 5 108903 3 29843567
Selective eating disorder 20.69 11.08 28 108880 1656 29841914
Congenital knee deformity 20.66 11.08 8 108900 55 29843515
Hot flush 20.65 11.08 14 108894 14666 29828904
Drug hypersensitivity 20.62 11.08 155 108753 68364 29775206
Electrocardiogram QT prolonged 20.56 11.08 210 108698 35625 29807945
Cholestasis 20.55 11.08 37 108871 24913 29818657
Limb discomfort 20.48 11.08 4 108904 9046 29834524
Congenital scoliosis 20.44 11.08 7 108901 32 29843538
Anomaly of external ear congenital 20.36 11.08 10 108898 129 29843441
Aura 20.31 11.08 13 108895 287 29843283
Agranulocytosis 20.25 11.08 143 108765 21799 29821771
Peritonitis bacterial 20.23 11.08 8 108900 11370 29832200
Foetal growth restriction 20.18 11.08 42 108866 3543 29840027
Microstomia 20.18 11.08 5 108903 4 29843566
Blood osmolarity decreased 20.14 11.08 17 108891 581 29842989
Reading disorder 20.03 11.08 13 108895 294 29843276
Faeces discoloured 20.02 11.08 13 108895 13933 29829637
Ehlers-Danlos syndrome 19.93 11.08 7 108901 35 29843535
Myoglobinuria 19.89 11.08 19 108889 765 29842805
Gingival hypertrophy 19.83 11.08 27 108881 1606 29841964
Excessive eye blinking 19.83 11.08 12 108896 239 29843331
Hepatic adenoma 19.77 11.08 7 108901 36 29843534
Nephropathy toxic 19.72 11.08 7 108901 10632 29832938
Mydriasis 19.69 11.08 58 108850 6085 29837485
Hyperexplexia 19.61 11.08 7 108901 37 29843533
Febrile bone marrow aplasia 19.59 11.08 3 108905 8094 29835476
Conductive deafness 19.58 11.08 9 108899 99 29843471
Hostility 19.50 11.08 20 108888 879 29842691
Maternal drugs affecting foetus 19.47 11.08 46 108862 4227 29839343
IVth nerve disorder 19.47 11.08 6 108902 18 29843552
Lennox-Gastaut syndrome 19.46 11.08 7 108901 38 29843532
Localised infection 19.46 11.08 13 108895 13724 29829846
Epidermolysis bullosa 19.42 11.08 9 108899 101 29843469
Haemangioma 19.31 11.08 24 108884 1304 29842266
Strabismus congenital 19.31 11.08 7 108901 39 29843531
Pulmonary arterial hypertension 19.27 11.08 5 108903 9296 29834274
Delusional perception 19.26 11.08 10 108898 146 29843424
Iris coloboma 19.23 11.08 6 108902 19 29843551
Neuralgia 19.21 11.08 7 108901 10459 29833111
Pelvic deformity 19.18 11.08 5 108903 6 29843564
Shock haemorrhagic 19.15 11.08 6 108902 9859 29833711
Hypokinesia 19.08 11.08 64 108844 7196 29836374
Neoplasm malignant 19.02 11.08 22 108886 17792 29825778
Neurological decompensation 19.02 11.08 32 108876 2296 29841274
Rash pruritic 19.02 11.08 33 108875 22539 29821031
Poverty of speech 19.01 11.08 11 108897 201 29843369
Dissociation 18.91 11.08 22 108886 1115 29842455
Gout 18.91 11.08 21 108887 17294 29826276
Bone marrow failure 18.91 11.08 51 108857 29734 29813836
Myelocyte count increased 18.90 11.08 8 108900 71 29843499
Encopresis 18.88 11.08 7 108901 42 29843528
Sarcopenia 18.86 11.08 12 108896 262 29843308
Coma blister 18.81 11.08 8 108900 72 29843498
Limb hypoplasia congenital 18.78 11.08 6 108902 21 29843549
Diffuse large B-cell lymphoma 18.76 11.08 3 108905 7838 29835732
Intermittent explosive disorder 18.75 11.08 5 108903 7 29843563
Drug abuse 18.72 11.08 410 108498 81662 29761908
Balance disorder 18.67 11.08 209 108699 36284 29807286
Aspiration 18.66 11.08 82 108826 10469 29833101
Trismus 18.65 11.08 32 108876 2333 29841237
Blood lactic acid increased 18.64 11.08 55 108853 5775 29837795
Candida infection 18.64 11.08 17 108891 15345 29828225
Metastases to bone 18.52 11.08 6 108902 9652 29833918
Retracted nipple 18.48 11.08 4 108904 0 29843570
Ear, nose and throat examination abnormal 18.48 11.08 4 108904 0 29843570
Laryngeal web 18.48 11.08 4 108904 0 29843570
Madarosis 18.45 11.08 11 108897 213 29843357
Frequent bowel movements 18.43 11.08 4 108904 8401 29835169
Craniofacial deformity 18.34 11.08 8 108900 77 29843493
Blood pressure fluctuation 18.28 11.08 22 108886 17481 29826089
Hyperthermia 18.25 11.08 79 108829 10020 29833550
Muscular weakness 18.20 11.08 146 108762 63499 29780071
Ageusia 18.19 11.08 5 108903 8948 29834622
Depressive symptom 18.19 11.08 26 108882 1619 29841951
Jaundice 18.18 11.08 59 108849 32427 29811143
Ammonia abnormal 18.16 11.08 8 108900 79 29843491
Type 1 diabetes mellitus 18.15 11.08 41 108867 3658 29839912
Adenoidectomy 18.09 11.08 7 108901 48 29843522
Cardiac disorder 18.07 11.08 79 108829 39814 29803756
Nephrogenic diabetes insipidus 18.06 11.08 22 108886 1171 29842399
Tic 18.05 11.08 29 108879 2003 29841567
Thought blocking 17.99 11.08 9 108899 121 29843449
Tooth malformation 17.96 11.08 6 108902 25 29843545
Sensory integrative dysfunction 17.96 11.08 6 108902 25 29843545
Simple partial seizures 17.94 11.08 12 108896 286 29843284
Pain in jaw 17.91 11.08 11 108897 12145 29831425
Hallucination, visual 17.90 11.08 110 108798 16003 29827567
Aptyalism 17.88 11.08 11 108897 226 29843344
Postural tremor 17.87 11.08 12 108896 288 29843282
Feeling hot 17.83 11.08 18 108890 15486 29828084
MELAS syndrome 17.77 11.08 6 108902 26 29843544
Pulmonary hypertension 17.77 11.08 26 108882 19010 29824560
Hyperhomocysteinaemia 17.77 11.08 10 108898 173 29843397
Neutrophil count decreased 17.74 11.08 234 108674 42220 29801350
Executive dysfunction 17.67 11.08 9 108899 126 29843444
Carnitine deficiency 17.61 11.08 7 108901 52 29843518
Hepatitis C virus test positive 17.50 11.08 14 108894 443 29843127
Overweight 17.46 11.08 24 108884 1441 29842129
Cataract 17.43 11.08 33 108875 21802 29821768
Gross motor delay 17.34 11.08 11 108897 239 29843331
Verbal abuse 17.27 11.08 10 108898 183 29843387
Drug level fluctuating 17.26 11.08 14 108894 452 29843118
Suspiciousness 17.25 11.08 13 108895 376 29843194
Impaired healing 17.25 11.08 16 108892 14324 29829246
Pulmonary mass 17.19 11.08 9 108899 10853 29832717
Transplant rejection 17.16 11.08 6 108902 9200 29834370
Wrong product administered 17.15 11.08 46 108862 4572 29838998
Heart disease congenital 17.13 11.08 22 108886 1236 29842334
Middle insomnia 17.09 11.08 53 108855 5720 29837850
Skin cancer 17.03 11.08 4 108904 7957 29835613
Mixed delusion 17.03 11.08 5 108903 12 29843558
Conjunctival hyperaemia 17.00 11.08 30 108878 2237 29841333
Squamous cell carcinoma 16.96 11.08 8 108900 10242 29833328
Throat irritation 16.95 11.08 5 108903 8543 29835027
Hypertension 16.93 11.08 325 108583 121029 29722541
Immune reconstitution inflammatory syndrome 16.85 11.08 6 108902 9095 29834475
Decreased gait velocity 16.79 11.08 8 108900 96 29843474
Cardiogenic shock 16.77 11.08 22 108886 16839 29826731
Schizoaffective disorder bipolar type 16.75 11.08 7 108901 60 29843510
Flatulence 16.69 11.08 25 108883 18104 29825466
Cholelithiasis 16.65 11.08 30 108878 20195 29823375
Polydipsia 16.58 11.08 39 108869 3574 29839996
Muscle twitching 16.47 11.08 66 108842 8089 29835481
Developmental regression 16.46 11.08 6 108902 34 29843536
Necrotising colitis 16.43 11.08 19 108889 957 29842613
Developmental hip dysplasia 16.34 11.08 11 108897 265 29843305
Urinary tract infection 16.33 11.08 180 108728 73479 29770091
Clostridium difficile infection 16.31 11.08 20 108888 15763 29827807
Gastric disorder 16.30 11.08 9 108899 10534 29833036
Reduced facial expression 16.28 11.08 17 108891 763 29842807
Hyperglycinaemia 16.26 11.08 4 108904 3 29843567
Inflammation 16.13 11.08 35 108873 21991 29821579
Diverticulitis 16.11 11.08 24 108884 17421 29826149
Ventricular septal defect 16.09 11.08 38 108870 3491 29840079
Irregular sleep phase 16.08 11.08 7 108901 67 29843503
Adrenal insufficiency 16.07 11.08 9 108899 10454 29833116
Excessive masturbation 16.03 11.08 8 108900 107 29843463
Pyrexia 15.98 11.08 892 108016 293597 29549973
Hypothyroidism 15.90 11.08 101 108807 14862 29828708
Ventricular tachycardia 15.80 11.08 40 108868 23822 29819748
Gastric ulcer 15.80 11.08 19 108889 15102 29828468
Epileptic psychosis 15.76 11.08 5 108903 17 29843553
Self-injurious ideation 15.73 11.08 24 108884 1585 29841985
Kyphosis congenital 15.72 11.08 4 108904 4 29843566
Dermatitis 15.72 11.08 5 108903 8137 29835433
Clostridium difficile colitis 15.65 11.08 14 108894 12754 29830816
Pleural effusion 15.64 11.08 183 108725 73883 29769687
Conversion disorder 15.46 11.08 12 108896 363 29843207
Abdominal distension 15.42 11.08 100 108808 45609 29797961
Dry skin 15.37 11.08 37 108871 22417 29821153
Social problem 15.33 11.08 16 108892 718 29842852
Tachyphrenia 15.22 11.08 19 108889 1037 29842533
Graft versus host disease 15.21 11.08 9 108899 10141 29833429
Squamous cell carcinoma of skin 15.20 11.08 7 108901 9088 29834482
Hypomagnesaemia 15.17 11.08 23 108885 16575 29826995
Lymphoma 15.13 11.08 9 108899 10112 29833458
Compensatory sweating 15.13 11.08 5 108903 20 29843550
Frontotemporal dementia 15.11 11.08 10 108898 234 29843336
Large intestine polyp 15.11 11.08 3 108905 6706 29836864
Supernumerary nipple 15.05 11.08 6 108902 45 29843525
Enterocolitis 15.04 11.08 3 108905 6684 29836886
Lower gastrointestinal haemorrhage 15.00 11.08 5 108903 7899 29835671
Poor quality sleep 14.94 11.08 59 108849 7182 29836388
Pulmonary oedema 14.94 11.08 96 108812 43879 29799691
Presyncope 14.92 11.08 22 108886 16034 29827536
Psychiatric decompensation 14.86 11.08 21 108887 1294 29842276
Body dysmorphic disorder 14.84 11.08 7 108901 82 29843488
Head deformity 14.84 11.08 7 108901 82 29843488
Psychomotor disadaptation syndrome 14.84 11.08 4 108904 6 29843564
Gingival atrophy 14.82 11.08 6 108902 47 29843523
Venoocclusive liver disease 14.80 11.08 3 108905 6610 29836960
Paradoxical drug reaction 14.77 11.08 31 108877 2631 29840939
Heat stroke 14.75 11.08 17 108891 853 29842717
Cerebral infarction 14.69 11.08 48 108860 26325 29817245
Cardiovascular disorder 14.67 11.08 11 108897 10941 29832629
Screaming 14.66 11.08 21 108887 1310 29842260
Cyanosis central 14.62 11.08 7 108901 85 29843485
Pneumonia bacterial 14.57 11.08 8 108900 9395 29834175
Pulmonary haemorrhage 14.54 11.08 8 108900 9384 29834186
Pancreatitis haemorrhagic 14.51 11.08 11 108897 321 29843249
Growth retardation 14.44 11.08 23 108885 1577 29841993
Posture abnormal 14.41 11.08 25 108883 1839 29841731
Terminal insomnia 14.39 11.08 12 108896 403 29843167
Automatism 14.34 11.08 7 108901 89 29843481
Otitis media 14.33 11.08 30 108878 2541 29841029
Sexually inappropriate behaviour 14.28 11.08 11 108897 329 29843241
Wrist deformity 14.22 11.08 11 108897 331 29843239
Miosis 14.18 11.08 61 108847 7715 29835855
Posterior reversible encephalopathy syndrome 14.15 11.08 66 108842 8641 29834929
Sperm concentration decreased 14.13 11.08 8 108900 140 29843430
Suspected suicide attempt 14.13 11.08 8 108900 140 29843430
Therapeutic response changed 14.08 11.08 11 108897 336 29843234
Use of accessory respiratory muscles 14.08 11.08 11 108897 336 29843234
Agitation neonatal 14.07 11.08 18 108890 1007 29842563
Cerebral cyst 14.01 11.08 9 108899 200 29843370
Coronary artery occlusion 13.95 11.08 12 108896 11145 29832425
Poor sucking reflex 13.93 11.08 10 108898 268 29843302
Oral mucosa erosion 13.90 11.08 16 108892 802 29842768
Hypocarnitinaemia 13.86 11.08 3 108905 0 29843570
Acquired epileptic aphasia 13.86 11.08 3 108905 0 29843570
Congenital neurological disorder 13.86 11.08 3 108905 0 29843570
Blindness congenital 13.86 11.08 3 108905 0 29843570
Mentally late developer 13.86 11.08 3 108905 0 29843570
Dacryoadenitis acquired 13.86 11.08 3 108905 0 29843570
Elbow deformity 13.86 11.08 3 108905 0 29843570
Acute pulmonary oedema 13.84 11.08 5 108903 7510 29836060
Reproductive tract hypoplasia, male 13.80 11.08 4 108904 9 29843561
Dyspepsia 13.77 11.08 60 108848 30269 29813301
CSF white blood cell count positive 13.77 11.08 5 108903 28 29843542
Blood pressure systolic increased 13.75 11.08 21 108887 15089 29828481
Personal relationship issue 13.74 11.08 8 108900 148 29843422
Oral candidiasis 13.73 11.08 12 108896 11059 29832511
Niemann-Pick disease 13.73 11.08 6 108902 58 29843512
Tendonitis 13.72 11.08 6 108902 8030 29835540
Micrognathia 13.71 11.08 10 108898 275 29843295
Apparent life threatening event 13.62 11.08 9 108899 210 29843360
Retinogram abnormal 13.62 11.08 7 108901 100 29843470
Blunted affect 13.61 11.08 10 108898 278 29843292
Haemorrhage intracranial 13.57 11.08 21 108887 15011 29828559
Renal tubular acidosis 13.52 11.08 24 108884 1798 29841772
Arachnoid cyst 13.51 11.08 9 108899 213 29843357
Syndactyly 13.50 11.08 15 108893 723 29842847
Delayed fontanelle closure 13.48 11.08 5 108903 30 29843540
Distributive shock 13.34 11.08 14 108894 632 29842938
Disseminated intravascular coagulation 13.30 11.08 39 108869 22132 29821438
Withdrawal syndrome 13.26 11.08 78 108830 11172 29832398
Aphasia 13.17 11.08 118 108790 19321 29824249
Colon cancer 13.15 11.08 7 108901 8365 29835205
Pancreatic carcinoma 13.15 11.08 6 108902 7831 29835739
Hypoxia 13.12 11.08 111 108797 47743 29795827
Myoglobin urine present 13.10 11.08 8 108900 162 29843408
Hepatitis B 13.09 11.08 3 108905 6069 29837501
Mental disability 13.08 11.08 5 108903 33 29843537
Respiratory fatigue 13.05 11.08 6 108902 66 29843504
Cholangitis 13.05 11.08 6 108902 7796 29835774
Locomotive syndrome 12.98 11.08 4 108904 12 29843558
Congenital cerebral cyst 12.98 11.08 4 108904 12 29843558
Enteritis 12.97 11.08 4 108904 6641 29836929
Haemorrhoids 12.96 11.08 15 108893 12126 29831444
Skin ulcer 12.95 11.08 31 108877 18818 29824752
Brachydactyly 12.93 11.08 8 108900 166 29843404
Camptocormia 12.93 11.08 8 108900 166 29843404
Hepatic cirrhosis 12.93 11.08 24 108884 15975 29827595
Dyslipidaemia 12.91 11.08 48 108860 5679 29837891
Throat tightness 12.88 11.08 5 108903 7187 29836383
Chromaturia 12.88 11.08 19 108889 13846 29829724
Blood osmolarity increased 12.87 11.08 10 108898 303 29843267
Injection site swelling 12.86 11.08 8 108900 8772 29834798
Procalcitonin increased 12.85 11.08 18 108890 1100 29842470
Back disorder 12.85 11.08 3 108905 5991 29837579
Diabetic coma 12.82 11.08 16 108892 873 29842697
Wrong schedule 12.81 11.08 7 108901 114 29843456
Polydipsia psychogenic 12.81 11.08 7 108901 114 29843456
Ear infection 12.81 11.08 57 108851 7317 29836253
Hallucination 12.79 11.08 250 108658 48809 29794761
Dementia with Lewy bodies 12.75 11.08 13 108895 567 29843003
Mass 12.73 11.08 5 108903 7135 29836435
Resting tremor 12.72 11.08 13 108895 569 29843001
Pharyngeal disorder 12.61 11.08 12 108896 481 29843089
Neonatal tachypnoea 12.60 11.08 7 108901 118 29843452
Abnormal labour affecting foetus 12.52 11.08 4 108904 14 29843556
Hepatocellular carcinoma 12.43 11.08 10 108898 9600 29833970
Impaired self-care 12.42 11.08 16 108892 902 29842668
Pericarditis 12.38 11.08 63 108845 8543 29835027
Joint range of motion decreased 12.38 11.08 3 108905 5842 29837728
Metamyelocyte count increased 12.38 11.08 6 108902 75 29843495
Gender dysphoria 12.37 11.08 5 108903 39 29843531
Deformity thorax 12.37 11.08 5 108903 39 29843531
Osteonecrosis 12.35 11.08 25 108883 16110 29827460
Embolism 12.34 11.08 5 108903 7004 29836566
Skin exfoliation 12.34 11.08 43 108865 23129 29820441
Erectile dysfunction 12.32 11.08 110 108798 17992 29825578
Incontinence 12.31 11.08 45 108863 5281 29838289
Myocardial ischaemia 12.28 11.08 28 108880 17289 29826281
Fungal infection 12.28 11.08 19 108889 13581 29829989
Neutropenic sepsis 12.28 11.08 14 108894 11395 29832175
Drowning 12.27 11.08 11 108897 408 29843162
Diarrhoea haemorrhagic 12.26 11.08 3 108905 5802 29837768
Loss of personal independence in daily activities 12.25 11.08 126 108782 21409 29822161
Feeding disorder 12.24 11.08 48 108860 5823 29837747
Gastrooesophageal reflux disease 12.23 11.08 68 108840 32187 29811383
Contraindicated product administered 12.11 11.08 28 108880 17203 29826367
Meningomyelocele 12.09 11.08 7 108901 128 29843442
Bronchitis 12.01 11.08 88 108820 39037 29804533
Snoring 11.98 11.08 30 108878 2861 29840709
Ischaemic cardiomyopathy 11.92 11.08 4 108904 6293 29837277
Anaemia megaloblastic 11.91 11.08 8 108900 192 29843378
Insomnia 11.91 11.08 433 108475 92903 29750667
Polyserositis 11.90 11.08 7 108901 132 29843438
Bronchospasm 11.89 11.08 12 108896 10326 29833244
Maternal exposure during pregnancy 11.89 11.08 36 108872 3835 29839735
Injection site erythema 11.86 11.08 20 108888 13814 29829756
Contusion 11.83 11.08 66 108842 31214 29812356
Injection site reaction 11.80 11.08 13 108895 10747 29832823
Ischaemic stroke 11.80 11.08 26 108882 16249 29827321
Mitochondrial DNULL mutation 11.79 11.08 3 108905 3 29843567
Post-anoxic myoclonus 11.79 11.08 3 108905 3 29843567
Toe walking 11.79 11.08 3 108905 3 29843567
Nasopharyngeal reflux 11.79 11.08 3 108905 3 29843567
Near drowning 11.79 11.08 3 108905 3 29843567
Eyelid exfoliation 11.79 11.08 3 108905 3 29843567
Kluver-Bucy syndrome 11.79 11.08 3 108905 3 29843567
Dependent personality disorder 11.75 11.08 5 108903 45 29843525
Homeless 11.73 11.08 4 108904 18 29843552
Hand-eye coordination impaired 11.73 11.08 4 108904 18 29843552
Sinus disorder 11.70 11.08 4 108904 6221 29837349
Lordosis 11.66 11.08 8 108900 199 29843371
Mouth breathing 11.66 11.08 6 108902 86 29843484
Superinfection 11.64 11.08 21 108887 1593 29841977
Device issue 11.61 11.08 7 108901 7809 29835761
Hip fracture 11.60 11.08 14 108894 11110 29832460
Spinal fracture 11.58 11.08 5 108903 6743 29836827
Abdominal pain lower 11.58 11.08 9 108899 8789 29834781
Nervousness 11.57 11.08 78 108830 11710 29831860
Keratosis pilaris 11.55 11.08 4 108904 19 29843551
Wound 11.51 11.08 17 108891 12385 29831185
Haemorrhagic stroke 11.47 11.08 4 108904 6143 29837427
Cardiac failure acute 11.40 11.08 10 108898 9199 29834371
Bone deformity 11.38 11.08 5 108903 49 29843521
Neutropenia 11.38 11.08 574 108334 127966 29715604
Idiopathic generalised epilepsy 11.33 11.08 3 108905 4 29843566
Congenital aortic anomaly 11.30 11.08 6 108902 92 29843478
Hyperreflexia 11.28 11.08 29 108879 2810 29840760
Myoglobin blood increased 11.28 11.08 22 108886 1771 29841799
Slow response to stimuli 11.28 11.08 14 108894 760 29842810
Vanishing bile duct syndrome 11.24 11.08 13 108895 655 29842915
Congenital genital malformation 11.23 11.08 4 108904 21 29843549
Pulmonary eosinophilia 11.22 11.08 8 108900 212 29843358
Base excess increased 11.21 11.08 5 108903 51 29843519
Spine malformation 11.20 11.08 7 108901 148 29843422
Abnormal palmar/plantar creases 11.16 11.08 8 108900 214 29843356
Blood glucose increased 11.14 11.08 157 108751 61373 29782197
Muscle contracture 11.12 11.08 17 108891 1125 29842445
Vasoplegia syndrome 11.10 11.08 18 108890 1253 29842317

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:35477 antimanics
CHEBI has role CHEBI:35623 antiepileptic
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35471 psychopharmaceuticals
CHEBI has role CHEBI:50905 teratogen
CHEBI has role CHEBI:61115 hdac inhibitor
CHEBI has role CHEBI:63726 neuroprotective agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase-related protein 1 Unclassified IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
3121 PUBCHEM_CID
CHEMBL433 ChEMBL_ID
CHEMBL109 ChEMBL_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL2315212 ChEMBL_ID
DB00313 DRUGBANK_ID
D014635 MESH_DESCRIPTOR_UI
5132 INN_ID
3300 INN_ID
644VL95AO6 UNII
7009 IUPHAR_LIGAND_ID
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
5641004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 30 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 30 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 30 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 30 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 30 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 30 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 31 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 29 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0527-5250 SOLUTION 250 mg ORAL ANDA 30 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0591-4012 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 29 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-1325 CAPSULE 250 mg ORAL ANDA 24 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0615-7840 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 27 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7949 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7950 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7956 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 28 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8205 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 23 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8237 CAPSULE 125 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8242 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 27 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8326 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8327 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8328 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8329 TABLET, EXTENDED RELEASE 250 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8330 TABLET, EXTENDED RELEASE 500 mg ORAL ANDA 28 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8376 TABLET, EXTENDED RELEASE 250 mg ORAL ANDA 28 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8377 TABLET, EXTENDED RELEASE 500 mg ORAL ANDA 28 sections