valproic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • epival
  • divalproex sodium
  • depakote
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1934.76 10.41 1820 109330 127689 53110227
Epilepsy 1130.04 10.41 691 110459 25076 53212840
Hyperammonaemic encephalopathy 1100.48 10.41 328 110822 1723 53236193
Hyperammonaemia 1087.92 10.41 408 110742 4741 53233175
Drug interaction 950.09 10.41 1664 109486 217665 53020251
Status epilepticus 932.20 10.41 507 110643 14677 53223239
Foetal anticonvulsant syndrome 618.11 10.41 156 110994 372 53237544
Somnolence 557.83 10.41 1138 110012 166596 53071320
Rheumatoid arthritis 550.45 10.41 25 111125 314506 52923410
Toxicity to various agents 510.98 10.41 1293 109857 218305 53019611
Aggression 493.25 10.41 401 110749 23002 53214914
Generalised tonic-clonic seizure 472.08 10.41 427 110723 28331 53209585
Sopor 465.00 10.41 371 110779 20713 53217203
Intentional overdose 454.07 10.41 627 110523 66578 53171338
Arthralgia 426.58 10.41 192 110958 439591 52798325
Ammonia increased 424.62 10.41 202 110948 4371 53233545
Dysmorphism 423.81 10.41 164 110986 2086 53235830
Pain 415.99 10.41 370 110780 588028 52649888
Psychotic disorder 407.97 10.41 366 110784 24019 53213897
Mania 401.25 10.41 270 110880 11559 53226357
Petit mal epilepsy 383.12 10.41 174 110976 3374 53234542
Overdose 368.44 10.41 740 110410 106996 53130920
Coma 360.93 10.41 538 110612 61245 53176671
Extrapyramidal disorder 354.87 10.41 255 110895 12147 53225769
Drug abuse 353.69 10.41 550 110600 64976 53172940
Multiple-drug resistance 353.59 10.41 160 110990 3075 53234841
Foetal exposure during pregnancy 351.79 10.41 397 110753 34318 53203598
Granulocytopenia 344.86 10.41 187 110963 5373 53232543
Intentional self-injury 343.34 10.41 338 110812 24946 53212970
Tremor 330.94 10.41 777 110373 124959 53112957
Suicide attempt 327.62 10.41 498 110652 57670 53180246
Neuroleptic malignant syndrome 327.43 10.41 240 110910 11793 53226123
Parkinsonism 320.81 10.41 212 110938 8801 53229115
Drug level increased 315.20 10.41 293 110857 20128 53217788
Sedation 310.32 10.41 345 110805 29330 53208586
Speech disorder developmental 299.07 10.41 89 111061 464 53237452
Joint swelling 297.59 10.41 63 111087 234575 53003341
Fatigue 286.89 10.41 693 110457 729813 52508103
Dyspnoea 277.18 10.41 500 110650 585732 52652184
Abnormal behaviour 274.24 10.41 280 110870 21586 53216330
Agitation 266.01 10.41 455 110695 58171 53179745
Developmental delay 252.05 10.41 97 111053 1214 53236702
Ataxia 248.05 10.41 222 110928 14515 53223401
Antipsychotic drug level increased 245.99 10.41 126 111024 3213 53234703
Drug reaction with eosinophilia and systemic symptoms 244.21 10.41 321 110829 32479 53205437
Depressed level of consciousness 242.44 10.41 419 110731 54009 53183907
Infusion related reaction 236.22 10.41 25 111125 155932 53081984
Drug level decreased 233.03 10.41 156 110994 6618 53231298
Cognitive disorder 227.91 10.41 366 110784 44412 53193504
Diarrhoea 227.05 10.41 617 110533 624929 52612987
Peripheral swelling 224.11 10.41 75 111075 206033 53031883
Bipolar disorder 222.09 10.41 159 110991 7527 53230389
Abdominal discomfort 219.39 10.41 93 111057 220969 53016947
Autism spectrum disorder 217.71 10.41 75 111075 667 53237249
Myoclonic epilepsy 215.95 10.41 82 111068 987 53236929
Arthropathy 205.91 10.41 26 111124 141427 53096489
Anticonvulsant drug level increased 200.06 10.41 84 111066 1336 53236580
Salivary hypersecretion 196.88 10.41 142 111008 6801 53231115
Learning disorder 196.36 10.41 64 111086 471 53237445
Contraindicated product administered 192.47 10.41 27 111123 135602 53102314
Intellectual disability 192.25 10.41 69 111081 700 53237216
Swelling 190.23 10.41 80 111070 191025 53046891
Schizoaffective disorder 186.47 10.41 91 111059 2086 53235830
Hypernatraemia 182.35 10.41 136 111014 6861 53231055
Sudden unexplained death in epilepsy 177.35 10.41 52 111098 255 53237661
Anticonvulsant drug level decreased 173.52 10.41 73 111077 1167 53236749
Nausea 172.98 10.41 901 110249 755190 52482726
Electrocardiogram QT prolonged 171.03 10.41 369 110781 56034 53181882
Abortion spontaneous 170.90 10.41 330 110820 46305 53191611
Encephalopathy 168.65 10.41 287 110863 36521 53201395
Irritability 167.15 10.41 260 110890 30693 53207223
Sinusitis 165.45 10.41 72 111078 168492 53069424
Nasopharyngitis 163.65 10.41 99 111051 192196 53045720
Pain in extremity 160.07 10.41 216 110934 284834 52953082
Anticonvulsant drug level above therapeutic 159.52 10.41 54 111096 453 53237463
Partial seizures 159.36 10.41 113 111037 5267 53232649
Hand deformity 157.76 10.41 4 111146 84845 53153071
Hypothermia 156.13 10.41 163 110987 12893 53225023
Schizophrenia 155.73 10.41 146 111004 10133 53227783
Disturbance in attention 152.15 10.41 264 110886 34119 53203797
Disorientation 150.98 10.41 284 110866 39075 53198841
Altered state of consciousness 150.28 10.41 220 110930 24616 53213300
Hallucination, auditory 149.86 10.41 152 110998 11621 53226295
Electroencephalogram abnormal 148.53 10.41 95 111055 3726 53234190
Systemic lupus erythematosus 146.44 10.41 40 111110 125374 53112542
Glossodynia 144.56 10.41 19 111131 100272 53137644
Treatment noncompliance 144.03 10.41 252 110898 32783 53205133
Congenital nose malformation 143.82 10.41 44 111106 256 53237660
Cough 142.85 10.41 196 110954 256697 52981219
Psychomotor retardation 140.30 10.41 90 111060 3548 53234368
Delusion 140.16 10.41 148 111002 11861 53226055
Drug intolerance 140.04 10.41 133 111017 205360 53032556
Hypotonia 137.38 10.41 128 111022 8813 53229103
Stevens-Johnson syndrome 136.24 10.41 209 110941 24373 53213543
Drug withdrawal convulsions 134.72 10.41 63 111087 1309 53236607
Learning disability 134.59 10.41 39 111111 182 53237734
Back pain 130.94 10.41 178 110972 234069 53003847
Exposure during pregnancy 129.91 10.41 560 110590 124300 53113616
Psychomotor skills impaired 127.94 10.41 72 111078 2227 53235689
Catatonia 126.99 10.41 88 111062 3952 53233964
Headache 126.77 10.41 632 110518 536189 52701727
Hypersensitivity 125.04 10.41 153 110997 210512 53027404
Suicidal ideation 120.62 10.41 337 110813 60174 53177742
Discomfort 120.14 10.41 26 111124 95446 53142470
Behaviour disorder 119.71 10.41 71 111079 2429 53235487
Dysarthria 117.94 10.41 261 110889 40307 53197609
Fanconi syndrome 117.52 10.41 55 111095 1145 53236771
Pruritus 116.82 10.41 276 110874 293556 52944360
Drug ineffective for unapproved indication 114.59 10.41 176 110974 20544 53217372
Bradyphrenia 114.20 10.41 102 111048 6648 53231268
Myoclonus 112.26 10.41 151 110999 15613 53222303
Muscle rigidity 111.50 10.41 125 111025 10716 53227200
Anticonvulsant drug level below therapeutic 108.81 10.41 42 111108 530 53237386
Psychomotor hyperactivity 108.30 10.41 119 111031 9977 53227939
Drug resistance 106.81 10.41 167 110983 19795 53218121
Psychogenic seizure 106.29 10.41 58 111092 1687 53236229
Paradoxical drug reaction 105.86 10.41 73 111077 3252 53234664
Product substitution issue 105.47 10.41 147 111003 15719 53222197
Completed suicide 104.82 10.41 566 110584 137635 53100281
Hyperprolactinaemia 103.71 10.41 72 111078 3243 53234673
Blood creatine phosphokinase increased 103.60 10.41 203 110947 28782 53209134
Hypomania 103.54 10.41 84 111066 4798 53233118
Injection site pain 102.70 10.41 54 111096 113337 53124579
Focal dyscognitive seizures 99.90 10.41 67 111083 2850 53235066
Febrile neutropenia 99.51 10.41 47 111103 104889 53133027
Confusional state 98.83 10.41 718 110432 193503 53044413
Tardive dyskinesia 98.73 10.41 102 111048 7968 53229948
Language disorder 98.69 10.41 57 111093 1854 53236062
Anaemia 97.63 10.41 276 110874 276442 52961474
Congenital hand malformation 96.23 10.41 33 111117 289 53237627
Educational problem 95.97 10.41 34 111116 331 53237585
Carnitine deficiency 95.72 10.41 28 111122 136 53237780
Pneumonia aspiration 95.58 10.41 217 110933 34084 53203832
Akathisia 95.38 10.41 103 111047 8468 53229448
Atonic seizures 94.77 10.41 39 111111 588 53237328
Meningomyelocele 94.63 10.41 38 111112 536 53237380
Stupor 94.03 10.41 72 111078 3779 53234137
Product residue present 93.44 10.41 74 111076 4082 53233834
Congenital foot malformation 92.53 10.41 29 111121 185 53237731
Nystagmus 91.94 10.41 86 111064 5950 53231966
Wound 91.55 10.41 38 111112 91519 53146397
Mental disorder 89.89 10.41 173 110977 24203 53213713
Skull malformation 89.12 10.41 32 111118 325 53237591
Arthritis 87.66 10.41 36 111114 87262 53150654
Cerebral atrophy 87.41 10.41 77 111073 4927 53232989
Plasma cell myeloma 86.27 10.41 3 111147 47871 53190045
Speech disorder 83.84 10.41 224 110926 38957 53198959
Herpes zoster 83.80 10.41 25 111125 73994 53163922
Delirium 83.80 10.41 232 110918 41197 53196719
Thrombocytopenia 82.49 10.41 533 110617 138194 53099722
Impaired healing 81.76 10.41 17 111133 64188 53173728
Therapeutic product effect decreased 81.32 10.41 85 111065 125570 53112346
Injection site erythema 80.63 10.41 30 111120 77219 53160697
Rhabdomyolysis 80.14 10.41 237 110913 43686 53194230
Cardiac failure congestive 79.90 10.41 47 111103 92710 53145206
Low set ears 78.28 10.41 28 111122 281 53237635
Death 77.71 10.41 432 110718 356800 52881116
Neuropathy peripheral 77.25 10.41 61 111089 103126 53134790
Rash 77.03 10.41 579 110571 445612 52792304
Psychiatric symptom 76.27 10.41 71 111079 4882 53233034
Limb malformation 76.03 10.41 32 111118 512 53237404
Toxic epidermal necrolysis 75.89 10.41 158 110992 23392 53214524
Talipes 75.45 10.41 44 111106 1458 53236458
Respiratory depression 75.38 10.41 112 111038 12694 53225222
Abdominal pain upper 75.34 10.41 145 111005 166146 53071770
Impulsive behaviour 74.85 10.41 44 111106 1480 53236436
Infection 74.72 10.41 154 110996 172051 53065865
Dyskinesia 73.23 10.41 187 110963 31646 53206270
Infantile spasms 73.04 10.41 26 111124 257 53237659
Chest pain 72.85 10.41 182 110968 190003 53047913
Propofol infusion syndrome 72.73 10.41 35 111115 777 53237139
Differential white blood cell count abnormal 72.72 10.41 34 111116 706 53237210
Persecutory delusion 71.66 10.41 53 111097 2639 53235277
Hypertelorism 71.17 10.41 28 111122 373 53237543
Psoriasis 71.04 10.41 47 111103 87042 53150874
Osteoarthritis 70.87 10.41 29 111121 70457 53167459
Motor developmental delay 70.48 10.41 21 111129 110 53237806
Affect lability 70.13 10.41 92 111058 9283 53228633
Stomatitis 69.81 10.41 61 111089 98097 53139819
Bipolar I disorder 69.54 10.41 44 111106 1693 53236223
Loss of consciousness 68.60 10.41 440 110710 113772 53124144
Urticaria 68.31 10.41 111 111039 135774 53102142
Pleurothotonus 68.22 10.41 40 111110 1339 53236577
Myocarditis 67.89 10.41 86 111064 8382 53229534
Arnold-Chiari malformation 67.10 10.41 29 111121 497 53237419
Ear malformation 67.01 10.41 23 111127 202 53237714
Tonic convulsion 67.01 10.41 38 111112 1193 53236723
Mental impairment 66.60 10.41 108 111042 13201 53224715
Weight increased 66.54 10.41 685 110465 203882 53034034
Drug level below therapeutic 66.32 10.41 58 111092 3675 53234241
Product dose omission issue 65.41 10.41 194 110956 191426 53046490
Gingival hypertrophy 64.84 10.41 40 111110 1471 53236445
Congenital eyelid malformation 64.59 10.41 13 111137 3 53237913
Dystonia 64.26 10.41 105 111045 12916 53225000
Acidosis hyperchloraemic 63.96 10.41 25 111125 327 53237589
Oculogyric crisis 62.86 10.41 39 111111 1449 53236467
Influenza 62.29 10.41 64 111086 95315 53142601
Resting tremor 62.07 10.41 31 111119 748 53237168
Intentional product use issue 62.05 10.41 37 111113 72457 53165459
Lethargy 62.02 10.41 249 110901 53511 53184405
Malignant neoplasm progression 61.96 10.41 36 111114 71505 53166411
Atrial septal defect 61.52 10.41 74 111076 6840 53231076
Ileus paralytic 61.37 10.41 61 111089 4550 53233366
Metabolic encephalopathy 60.99 10.41 68 111082 5793 53232123
Strabismus 59.88 10.41 42 111108 1923 53235993
Brain oedema 59.83 10.41 104 111046 13454 53224462
Gastrointestinal haemorrhage 59.48 10.41 48 111102 80282 53157634
Blood prolactin increased 58.91 10.41 51 111099 3188 53234728
Toxic encephalopathy 58.67 10.41 67 111083 5860 53232056
Nasal congestion 58.52 10.41 19 111131 53268 53184648
Suicidal behaviour 58.49 10.41 46 111104 2512 53235404
Leukopenia 58.46 10.41 305 110845 73158 53164758
Blood pressure increased 58.12 10.41 129 111021 140350 53097566
Stillbirth 57.64 10.41 71 111079 6726 53231190
Productive cough 57.59 10.41 23 111127 56706 53181210
Mitochondrial DNA mutation 57.07 10.41 21 111129 230 53237686
Dementia 57.07 10.41 115 111035 16635 53221281
Seizure cluster 56.61 10.41 20 111130 193 53237723
Dyspnoea exertional 56.32 10.41 22 111128 54978 53182938
Hyperlactacidaemia 55.92 10.41 46 111104 2679 53235237
Abdominal pain 55.83 10.41 309 110841 255594 52982322
Neurodevelopmental disorder 55.41 10.41 12 111138 9 53237907
Atrial fibrillation 55.37 10.41 92 111058 111560 53126356
Flushing 55.06 10.41 40 111110 70560 53167356
Paranoia 54.86 10.41 91 111059 11333 53226583
White blood cell count increased 54.79 10.41 216 110934 46029 53191887
Musculoskeletal stiffness 54.62 10.41 109 111041 123259 53114657
Restlessness 54.54 10.41 155 110995 27932 53209984
Microcephaly 54.53 10.41 29 111121 800 53237116
Folliculitis 53.81 10.41 3 111147 31706 53206210
Fluid retention 53.70 10.41 23 111127 54378 53183538
Antipsychotic drug level decreased 53.36 10.41 19 111131 188 53237728
Enuresis 53.24 10.41 41 111109 2170 53235746
Psoriatic arthropathy 53.24 10.41 17 111133 48173 53189743
Pericarditis 52.20 10.41 35 111115 64371 53173545
Hypoaesthesia 51.90 10.41 126 111024 132869 53105047
Alopecia 51.86 10.41 282 110868 234301 53003615
Myalgia 51.67 10.41 127 111023 133364 53104552
Attention deficit hyperactivity disorder 51.62 10.41 43 111107 2549 53235367
Injection site reaction 51.52 10.41 21 111129 51145 53186771
Communication disorder 51.46 10.41 42 111108 2419 53235497
Cerebellar atrophy 51.29 10.41 26 111124 648 53237268
Bronchitis 51.16 10.41 97 111053 111802 53126114
Mental status changes 51.13 10.41 190 110960 39381 53198535
Injection site pruritus 50.95 10.41 12 111138 41577 53196339
Thrombosis 50.68 10.41 32 111118 60761 53177155
Helicobacter infection 50.45 10.41 10 111140 39059 53198857
Muscle injury 49.95 10.41 3 111147 29763 53208153
Hypokinesia 49.93 10.41 94 111056 12933 53224983
Drug hypersensitivity 49.65 10.41 336 110814 264906 52973010
Rhinorrhoea 49.25 10.41 25 111125 53553 53184363
Knee arthroplasty 49.22 10.41 6 111144 33563 53204353
Bone pain 49.18 10.41 22 111128 50700 53187216
Neutrophil count increased 48.49 10.41 102 111048 15208 53222708
Poisoning 48.27 10.41 96 111054 13754 53224162
Depressed mood 48.19 10.41 178 110972 36786 53201130
Spina bifida 47.71 10.41 26 111124 754 53237162
Grandiosity 47.67 10.41 18 111132 213 53237703
Injection site swelling 47.16 10.41 15 111135 42613 53195303
Wheezing 47.09 10.41 40 111110 65235 53172681
Gastrointestinal disorder 46.66 10.41 72 111078 89932 53147984
Angiofibroma 46.54 10.41 15 111135 106 53237810
Selective eating disorder 46.48 10.41 36 111114 1922 53235994
Congenital scoliosis 46.47 10.41 10 111140 7 53237909
Musculoskeletal pain 46.28 10.41 53 111097 75147 53162769
Asthenia 45.88 10.41 476 110674 343114 52894802
Hepatic failure 45.49 10.41 171 110979 35635 53202281
Blood pressure systolic increased 45.43 10.41 9 111141 35168 53202748
Disease progression 45.16 10.41 90 111060 101830 53136086
Abortion induced 45.13 10.41 81 111069 10745 53227171
Intra-abdominal pressure increased 44.74 10.41 17 111133 205 53237711
Bradykinesia 44.43 10.41 50 111100 4303 53233613
Carnitine decreased 44 10.41 9 111141 3 53237913
Chills 43.58 10.41 96 111054 104752 53133164
Lip disorder 43.57 10.41 29 111121 1218 53236698
Chest discomfort 43.35 10.41 89 111061 99606 53138310
Pectus excavatum 43.33 10.41 13 111137 70 53237846
Anger 43.33 10.41 86 111064 12304 53225612
Coordination abnormal 43.06 10.41 84 111066 11867 53226049
Hypertension 42.96 10.41 284 110866 225147 53012769
Logorrhoea 42.91 10.41 38 111112 2448 53235468
Craniosynostosis 42.81 10.41 15 111135 141 53237775
Ventricular septal defect 42.76 10.41 49 111101 4301 53233615
Myopia 42.54 10.41 31 111119 1508 53236408
Affective disorder 42.43 10.41 55 111095 5484 53232432
Refusal of treatment by patient 42.42 10.41 55 111095 5485 53232431
Interstitial lung disease 42.19 10.41 36 111114 58586 53179330
Tonic clonic movements 42.03 10.41 29 111121 1293 53236623
Dyspraxia 42.00 10.41 17 111133 245 53237671
Hot flush 41.88 10.41 23 111127 47137 53190779
Hallucination 41.78 10.41 222 110928 53616 53184300
Hallucinations, mixed 40.77 10.41 48 111102 4338 53233578
Mood swings 40.50 10.41 103 111047 17383 53220533
Pain in jaw 40.45 10.41 17 111133 40652 53197264
Drop attacks 40.39 10.41 23 111127 728 53237188
Eosinophilic pleural effusion 40.36 10.41 11 111139 39 53237877
Amenorrhoea 40.32 10.41 71 111079 9278 53228638
Reflexes abnormal 40.25 10.41 22 111128 642 53237274
Inflammation 40.02 10.41 36 111114 57100 53180816
Psychotic symptom 39.81 10.41 26 111124 1057 53236859
Dry skin 39.66 10.41 23 111127 45737 53192179
Asterixis 39.65 10.41 28 111122 1296 53236620
Acute hepatic failure 39.26 10.41 99 111051 16621 53221295
Oropharyngeal oedema 39.20 10.41 16 111134 236 53237680
Injection site bruising 38.64 10.41 15 111135 37631 53200285
Adjustment disorder with mixed anxiety and depressed mood 38.63 10.41 12 111138 74 53237842
Epistaxis 38.53 10.41 52 111098 68658 53169258
Astigmatism 38.51 10.41 25 111125 1006 53236910
Oral mucosa erosion 38.49 10.41 26 111124 1119 53236797
Limbic encephalitis 38.42 10.41 16 111134 249 53237667
Antipsychotic drug level above therapeutic 38.40 10.41 25 111125 1011 53236905
Tachycardia 38.35 10.41 369 110781 107843 53130073
Malaise 38.28 10.41 520 110630 357097 52880819
Gene mutation 38.12 10.41 27 111123 1256 53236660
Muscle spasms 38.11 10.41 148 111002 134647 53103269
Psychotic behaviour 38.01 10.41 21 111129 626 53237290
Change in seizure presentation 37.85 10.41 16 111134 259 53237657
Depressive symptom 37.68 10.41 40 111110 3224 53234692
Asthma 37.39 10.41 110 111040 108862 53129054
Dysmetria 37.14 10.41 18 111132 406 53237510
Posture abnormal 36.88 10.41 34 111116 2309 53235607
Hyperthermia 36.86 10.41 65 111085 8504 53229412
Metabolic acidosis 36.84 10.41 180 110970 42062 53195854
Congenital anomaly 36.80 10.41 29 111121 1588 53236328
Personal relationship issue 36.57 10.41 10 111140 36 53237880
Poor sucking reflex 36.39 10.41 14 111136 175 53237741
Hypertonia 36.23 10.41 47 111103 4690 53233226
Blood lactic acid increased 36.22 10.41 53 111097 5925 53231991
Pneumatosis 36.13 10.41 18 111132 432 53237484
Antipsychotic drug level below therapeutic 36.05 10.41 16 111134 293 53237623
Dyslexia 36.05 10.41 16 111134 293 53237623
Galactorrhoea 35.94 10.41 43 111107 3952 53233964
Sinus rhythm 35.87 10.41 21 111129 701 53237215
Aphasia 35.84 10.41 143 111007 30635 53207281
Oropharyngeal pain 35.79 10.41 72 111078 81196 53156720
Lordosis 35.76 10.41 16 111134 299 53237617
Haematochezia 35.71 10.41 22 111128 42336 53195580
Treatment failure 35.65 10.41 142 111008 128261 53109655
Pneumonia 35.44 10.41 616 110534 406553 52831363
Throat irritation 35.31 10.41 11 111139 31670 53206246
Neovascularisation 35.29 10.41 20 111130 627 53237289
Delusion of grandeur 35.28 10.41 13 111137 143 53237773
Cogwheel rigidity 35.18 10.41 29 111121 1694 53236222
Congenital hair disorder 35.17 10.41 10 111140 43 53237873
Hyperchloraemia 35.13 10.41 21 111129 729 53237187
Clinodactyly 35.00 10.41 12 111138 105 53237811
Camptodactyly congenital 34.94 10.41 8 111142 10 53237906
Anaphylactic reaction 34.93 10.41 42 111108 58284 53179632
C-reactive protein abnormal 34.74 10.41 6 111144 25864 53212052
Fungal infection 34.53 10.41 12 111138 32234 53205682
Apathy 34.40 10.41 62 111088 8250 53229666
Myocardial infarction 34.30 10.41 100 111050 99254 53138662
Sluggishness 34.26 10.41 46 111104 4746 53233170
Urinary incontinence 34.14 10.41 141 111009 30680 53207236
Bradycardia neonatal 33.96 10.41 22 111128 882 53237034
Cataract 33.88 10.41 32 111118 49588 53188328
Partial seizures with secondary generalisation 33.80 10.41 16 111134 342 53237574
Hyperglycinaemia 33.74 10.41 7 111143 3 53237913
Speech sound disorder 33.74 10.41 7 111143 3 53237913
Cardiac failure 33.73 10.41 81 111069 85763 53152153
Contusion 33.65 10.41 118 111032 110614 53127302
Neutropenia 33.41 10.41 491 110659 158694 53079222
Obesity 33.38 10.41 93 111057 16569 53221347
Encephalitis autoimmune 33.34 10.41 25 111125 1271 53236645
Weight decreased 33.19 10.41 321 110829 234627 53003289
Hypophosphataemic osteomalacia 33.12 10.41 13 111137 172 53237744
Weight gain poor 33.12 10.41 21 111129 811 53237105
Gaze palsy 33.07 10.41 26 111124 1419 53236497
Multiple congenital abnormalities 33.06 10.41 18 111132 521 53237395
Anticonvulsant drug level abnormal 33.00 10.41 9 111141 32 53237884
Retinogram abnormal 32.98 10.41 12 111138 127 53237789
Porphyria acute 32.85 10.41 18 111132 528 53237388
Plagiocephaly 32.71 10.41 10 111140 58 53237858
Polydipsia 32.56 10.41 38 111112 3402 53234514
Necrosis ischaemic 32.50 10.41 21 111129 838 53237078
Unresponsive to stimuli 32.49 10.41 147 111003 33279 53204637
Diverticulitis 32.47 10.41 17 111133 35784 53202132
Cystitis 32.44 10.41 30 111120 46958 53190958
Arachnodactyly 32.42 10.41 10 111140 60 53237856
Irritable bowel syndrome 32.38 10.41 26 111124 43606 53194310
Neoplasm progression 32.27 10.41 11 111139 29908 53208008
Psychiatric decompensation 32.24 10.41 25 111125 1337 53236579
Localised infection 32.15 10.41 8 111142 26708 53211208
Mydriasis 31.93 10.41 72 111078 11254 53226662
Angiomyolipoma 31.83 10.41 13 111137 192 53237724
Palpitations 31.82 10.41 108 111042 102240 53135676
Rabbit syndrome 31.76 10.41 15 111135 319 53237597
Nipple disorder 31.62 10.41 11 111139 101 53237815
COVID-19 31.32 10.41 19 111131 36869 53201047
Drug level above therapeutic 31.21 10.41 40 111110 3944 53233972
Dysgraphia 31.20 10.41 34 111116 2823 53235093
Hypersexuality 31.13 10.41 17 111133 495 53237421
Gait disturbance 31.04 10.41 484 110666 158358 53079558
Breast hyperplasia 31.03 10.41 14 111136 267 53237649
Pulmonary arterial hypertension 30.98 10.41 9 111141 27113 53210803
Nephrogenic diabetes insipidus 30.84 10.41 21 111129 916 53237000
Renal tubular acidosis 30.69 10.41 27 111123 1724 53236192
Screaming 30.68 10.41 36 111114 3241 53234675
Hepatic function abnormal 30.59 10.41 155 110995 36744 53201172
Paraesthesia 30.56 10.41 149 111001 127366 53110550
Hip arthroplasty 30.47 10.41 10 111140 27852 53210064
Congenital joint malformation 30.46 10.41 7 111143 9 53237907
Device expulsion 30.40 10.41 12 111138 29801 53208115
Drooling 30.32 10.41 37 111113 3471 53234445
Constipation 30.21 10.41 266 110884 198146 53039770
Glycosuria 30.04 10.41 23 111127 1207 53236709
Metabolic disorder 29.86 10.41 46 111104 5381 53232535
Respiratory disorder neonatal 29.82 10.41 21 111129 968 53236948
Night sweats 29.67 10.41 18 111132 34929 53202987
Ovarian granulosa-theca cell tumour 29.66 10.41 8 111142 27 53237889
Deafness congenital 29.64 10.41 7 111143 11 53237905
Inappropriate antidiuretic hormone secretion 29.51 10.41 83 111067 14868 53223048
Foetal death 29.28 10.41 62 111088 9285 53228631
Hyponatraemia 29.01 10.41 350 110800 108257 53129659
Cleft palate 28.97 10.41 21 111129 1013 53236903
Osteonecrosis of jaw 28.81 10.41 20 111130 36126 53201790
Congenital oral malformation 28.80 10.41 12 111138 187 53237729
Strabismus congenital 28.80 10.41 8 111142 31 53237885
Automatism 28.77 10.41 9 111141 57 53237859
Skin ulcer 28.76 10.41 20 111130 36099 53201817
Mucosal inflammation 28.73 10.41 28 111122 42756 53195160
Conjunctival hyperaemia 28.66 10.41 29 111121 2210 53235706
Tooth malformation 28.63 10.41 6 111144 3 53237913
Balance disorder 28.63 10.41 255 110895 72952 53164964
High arched palate 28.38 10.41 9 111141 60 53237856
Lower respiratory tract infection 28.28 10.41 96 111054 90885 53147031
Acute kidney injury 28.28 10.41 366 110784 253502 52984414
Brief psychotic disorder, with postpartum onset 28.21 10.41 8 111142 34 53237882
Motor dysfunction 28.20 10.41 57 111093 8261 53229655
Verbal abuse 27.81 10.41 10 111140 102 53237814
Tic 27.67 10.41 23 111127 1359 53236557
Accidental overdose 27.63 10.41 103 111047 21376 53216540
Neck pain 27.44 10.41 52 111098 59964 53177952
Hallucination, visual 27.38 10.41 94 111056 18738 53219178
Metastases to bone 27.04 10.41 4 111146 19324 53218592
Congenital central nervous system anomaly 26.97 10.41 14 111136 367 53237549
Respiratory acidosis 26.89 10.41 48 111102 6340 53231576
Pulmonary hypertension 26.68 10.41 23 111127 37247 53200669
Hepatic enzyme increased 26.60 10.41 154 110996 126041 53111875
Cellulitis 26.58 10.41 76 111074 75913 53162003
Blood gases abnormal 26.57 10.41 17 111133 667 53237249
General physical health deterioration 26.54 10.41 188 110962 146754 53091162
Gastrooesophageal reflux disease 26.54 10.41 86 111064 82577 53155339
Polycystic ovaries 26.47 10.41 28 111122 2248 53235668
Dacryostenosis congenital 26.43 10.41 6 111144 7 53237909
Reading disorder 26.36 10.41 18 111132 789 53237127
Subileus 26.32 10.41 33 111117 3183 53234733
Polydactyly 26.14 10.41 14 111136 392 53237524
Congenital flat feet 25.88 10.41 5 111145 0 53237916
Leukocytosis 25.72 10.41 111 111039 24623 53213293
Urinary tract infection 25.57 10.41 349 110801 239554 52998362
Product use in unapproved indication 25.41 10.41 351 110799 111938 53125978
Borderline personality disorder 25.29 10.41 17 111133 726 53237190
Hypermobility syndrome 25.18 10.41 17 111133 731 53237185
Hepatotoxicity 25.17 10.41 120 111030 27760 53210156
Physical assault 25.12 10.41 19 111131 979 53236937
Echolalia 25.11 10.41 11 111139 195 53237721
Monocytosis 25.04 10.41 13 111137 341 53237575
Palmar-plantar erythrodysaesthesia syndrome 24.99 10.41 7 111143 21599 53216317
Obsessive-compulsive disorder 24.82 10.41 34 111116 3576 53234340
Pancreatitis 24.81 10.41 173 110977 45969 53191947
Rotavirus infection 24.67 10.41 12 111138 273 53237643
Lennox-Gastaut syndrome 24.63 10.41 12 111138 274 53237642
Depression 24.59 10.41 526 110624 182526 53055390
Vestibular migraine 24.56 10.41 11 111139 206 53237710
Mood altered 24.39 10.41 74 111076 13827 53224089
Euphoric mood 24.38 10.41 38 111112 4491 53233425
Hereditary ataxia 24.27 10.41 7 111143 32 53237884
Akinesia 24.27 10.41 25 111125 1946 53235970
Injection site rash 24.22 10.41 3 111147 16576 53221340
Eye movement disorder 24.21 10.41 40 111110 4965 53232951
Pulmonary fibrosis 24.14 10.41 10 111140 24125 53213791
Precocious puberty 24.13 10.41 11 111139 215 53237701
Erythema 24.08 10.41 210 110940 156759 53081157
Cerebrovascular accident 24.00 10.41 125 111025 105049 53132867
Rash maculo-papular 23.99 10.41 124 111026 29625 53208291
Lactate pyruvate ratio increased 23.95 10.41 9 111141 105 53237811
Illogical thinking 23.85 10.41 8 111142 65 53237851
Prognathism 23.85 10.41 8 111142 65 53237851
Joint stiffness 23.81 10.41 17 111133 30266 53207650
Bipolar II disorder 23.68 10.41 12 111138 299 53237617
Dysgeusia 23.55 10.41 33 111117 42898 53195018
Staring 23.43 10.41 22 111128 1529 53236387
Cerebellar syndrome 23.35 10.41 33 111117 3574 53234342
Conductive deafness 23.33 10.41 8 111142 70 53237846
Lymphangioleiomyomatosis 23.32 10.41 10 111140 168 53237748
Social avoidant behaviour 23.25 10.41 30 111120 2978 53234938
Breast cancer 23.24 10.41 42 111108 49316 53188600
Fibromyalgia 23.08 10.41 35 111115 44040 53193876
Metabolic syndrome 22.94 10.41 21 111129 1413 53236503
Retinitis pigmentosa 22.94 10.41 9 111141 119 53237797
Conversion disorder 22.91 10.41 23 111127 1736 53236180
Growth retardation 22.83 10.41 19 111131 1125 53236791
Fluid overload 22.71 10.41 15 111135 27816 53210100
Apraxia 22.70 10.41 23 111127 1755 53236161
Vomiting 22.59 10.41 828 110322 496311 52741605
Surgery 22.55 10.41 20 111130 31944 53205972
Right ventricular failure 22.41 10.41 4 111146 16839 53221077
Full blood count decreased 22.40 10.41 11 111139 24018 53213898
Stereotypy 22.34 10.41 13 111137 429 53237487
Disinhibition 22.34 10.41 17 111133 884 53237032
Diplopia 22.22 10.41 94 111056 20671 53217245
Pneumonitis 22.18 10.41 19 111131 30869 53207047
Loss of personal independence in daily activities 22.15 10.41 73 111077 69742 53168174
Schizoaffective disorder bipolar type 22.09 10.41 9 111141 132 53237784
Illiteracy 22.07 10.41 6 111144 21 53237895
Agranulocytosis 22.01 10.41 103 111047 23646 53214270
Hirsutism 21.86 10.41 18 111132 1050 53236866
Hypotonia neonatal 21.78 10.41 18 111132 1055 53236861
Pancreatitis necrotising 21.61 10.41 21 111129 1524 53236392
Basal cell carcinoma 21.49 10.41 11 111139 23458 53214458
Tachyphrenia 21.41 10.41 20 111130 1381 53236535
Upper respiratory tract infection 21.41 10.41 73 111077 69024 53168892
Mutism 21.27 10.41 20 111130 1393 53236523
Developmental regression 21.25 10.41 6 111144 25 53237891
Oral pain 21.19 10.41 15 111135 26822 53211094
Epileptic encephalopathy 21.14 10.41 11 111139 290 53237626
Right ventricular hypertrophy 21.04 10.41 15 111135 705 53237211
Blood count abnormal 21.00 10.41 8 111142 20307 53217609
Eosinophilia 20.86 10.41 94 111056 21241 53216675
Intentional product misuse 20.85 10.41 175 110975 49217 53188699
Feeling hot 20.80 10.41 34 111116 41510 53196406
Intelligence test abnormal 20.70 10.41 4 111146 0 53237916
Anomaly of orbit, congenital 20.70 10.41 4 111146 0 53237916
Optic nerve hypoplasia 20.70 10.41 4 111146 0 53237916
Injection site haemorrhage 20.70 10.41 10 111140 22041 53215875
Renal failure 20.68 10.41 153 110997 118299 53119617
Heart rate decreased 20.67 10.41 28 111122 36919 53200997
Congenital cystic kidney disease 20.59 10.41 12 111138 397 53237519
Dehydration 20.55 10.41 238 110912 168172 53069744
Drug eruption 20.51 10.41 105 111045 24989 53212927
Nephrocalcinosis 20.49 10.41 17 111133 1002 53236914
Negativism 20.40 10.41 12 111138 404 53237512
Mitochondrial enzyme deficiency 20.37 10.41 6 111144 30 53237886
Clonus 20.36 10.41 34 111116 4257 53233659
Sinus congestion 20.36 10.41 3 111147 14535 53223381
Inappropriate affect 20.35 10.41 16 111134 873 53237043
Miosis 20.28 10.41 45 111105 6957 53230959
Brain death 20.18 10.41 28 111122 2980 53234936
Medication overuse headache 20.06 10.41 14 111136 636 53237280
Drug withdrawal syndrome 20.02 10.41 113 111037 27909 53210007
Food interaction 20.00 10.41 14 111136 639 53237277
Sputum discoloured 19.98 10.41 3 111147 14336 53223580
Drug screen false positive 19.98 10.41 16 111134 897 53237019
Bursitis 19.93 10.41 11 111139 22481 53215435
Mitochondrial cytopathy 19.85 10.41 11 111139 330 53237586
Acquired macroglossia 19.84 10.41 9 111141 174 53237742
Hiatus hernia 19.83 10.41 8 111142 19612 53218304
Spinal stenosis 19.80 10.41 3 111147 14238 53223678
Metastases to liver 19.80 10.41 10 111140 21486 53216430
Pancreatitis acute 19.80 10.41 107 111043 26002 53211914
Sexually inappropriate behaviour 19.78 10.41 8 111142 115 53237801
Cross sensitivity reaction 19.66 10.41 23 111127 2064 53235852
Flatulence 19.62 10.41 22 111128 31495 53206421
Withdrawal syndrome 19.60 10.41 86 111064 19215 53218701
Pneumocystis jirovecii pneumonia 19.52 10.41 5 111145 16373 53221543
Ascites 19.45 10.41 33 111117 39702 53198214
Macroglossia 19.41 10.41 14 111136 670 53237246
Reduced facial expression 19.38 10.41 21 111129 1733 53236183
Neglect of personal appearance 19.36 10.41 8 111142 122 53237794
Increased appetite 19.35 10.41 52 111098 9070 53228846
Neoplasm malignant 19.32 10.41 15 111135 25586 53212330
Perseveration 19.24 10.41 10 111140 263 53237653
Haemoptysis 19.24 10.41 18 111132 28021 53209895
Epileptic psychosis 19.18 10.41 6 111144 38 53237878
Clostridium difficile infection 19.02 10.41 18 111132 27875 53210041
Congenital hepatomegaly 18.98 10.41 5 111145 15 53237901
Pulmonary mass 18.89 10.41 9 111141 19995 53217921
Influenza B virus test positive 18.79 10.41 11 111139 367 53237549
Ultrasound ovary abnormal 18.76 10.41 7 111143 80 53237836
Lipids 18.74 10.41 5 111145 16 53237900
Congenital hearing disorder 18.74 10.41 5 111145 16 53237900
Blood pressure fluctuation 18.74 10.41 28 111122 35442 53202474
Hypothyroidism 18.61 10.41 134 111016 35973 53201943
Attention-seeking behaviour 18.60 10.41 7 111143 82 53237834
Device issue 18.60 10.41 11 111139 21647 53216269
Congenital musculoskeletal anomaly 18.57 10.41 12 111138 479 53237437
Blood insulin increased 18.57 10.41 8 111142 136 53237780
Ear disorder 18.57 10.41 29 111121 3433 53234483
Microstomia 18.47 10.41 4 111146 3 53237913
Hip fracture 18.39 10.41 19 111131 28238 53209678
Ulcer 18.39 10.41 10 111140 20609 53217307
Prominent epicanthal folds 18.31 10.41 6 111144 45 53237871
Urine amphetamine positive 18.31 10.41 6 111144 45 53237871
Hypersomnia 18.25 10.41 75 111075 16280 53221636
Cerebral ventricle dilatation 18.20 10.41 16 111134 1021 53236895
Hypermetropia 18.20 10.41 12 111138 496 53237420
Red blood cell sedimentation rate increased 18.11 10.41 19 111131 28038 53209878
Coronary artery disease 18.05 10.41 26 111124 33411 53204505
Transient aphasia 17.97 10.41 6 111144 48 53237868
Limb discomfort 17.96 10.41 16 111134 25506 53212410
Lipid metabolism disorder 17.76 10.41 6 111144 50 53237866
Drug level changed 17.71 10.41 8 111142 153 53237763
VIth nerve paralysis 17.70 10.41 14 111136 771 53237145
Osmolar gap increased 17.68 10.41 5 111145 21 53237895
Aspiration 17.58 10.41 54 111096 10156 53227760
Thinking abnormal 17.56 10.41 55 111095 10453 53227463
Product use issue 17.52 10.41 196 110954 139388 53098528
Urine sodium increased 17.48 10.41 7 111143 98 53237818
Eye pain 17.48 10.41 23 111127 30702 53207214
Laryngeal stenosis 17.37 10.41 14 111136 792 53237124
Kidney infection 17.37 10.41 9 111141 19058 53218858
Acute generalised exanthematous pustulosis 17.36 10.41 54 111096 10227 53227689
Osteoporosis 17.34 10.41 45 111105 46415 53191501
Monocyte count decreased 17.25 10.41 21 111129 1965 53235951
Microphthalmos 17.25 10.41 8 111142 163 53237753
Brachydactyly 17.23 10.41 7 111143 102 53237814
Benign congenital hypotonia 17.16 10.41 6 111144 56 53237860
Cardiac disorder 17.14 10.41 46 111104 46920 53190996
School refusal 17.05 10.41 4 111146 6 53237910
Spina bifida occulta 17.05 10.41 4 111146 6 53237910
Hostility 17.05 10.41 19 111131 1618 53236298
Hyperkalaemia 17.03 10.41 57 111093 54199 53183717
Nasal disorder 16.94 10.41 23 111127 2398 53235518
Bladder sphincter atony 16.90 10.41 8 111142 171 53237745
Incontinence 16.84 10.41 55 111095 10688 53227228
Acute myocardial infarction 16.82 10.41 27 111123 33208 53204708
Micrognathia 16.80 10.41 9 111141 252 53237664
Cardiac steatosis 16.79 10.41 6 111144 60 53237856
Haemorrhoids 16.78 10.41 11 111139 20478 53217438
Diabetes mellitus 16.77 10.41 179 110971 53720 53184196
Injection site urticaria 16.76 10.41 3 111147 12604 53225312
Transfusion 16.66 10.41 4 111146 13683 53224233
Faeces discoloured 16.63 10.41 8 111142 17678 53220238
Head titubation 16.49 10.41 13 111137 712 53237204
Musculoskeletal discomfort 16.47 10.41 6 111144 15654 53222262
Device related infection 16.38 10.41 14 111136 22772 53215144
Ketosis-prone diabetes mellitus 16.33 10.41 4 111146 8 53237908
Dyscalculia 16.28 10.41 6 111144 66 53237850
Impaired reasoning 16.20 10.41 6 111144 67 53237849
Executive dysfunction 16.14 10.41 7 111143 121 53237795
Renal hypoplasia 16.07 10.41 5 111145 31 53237885
Asphyxia 16.06 10.41 37 111113 5864 53232052
Parkinsonian gait 16.05 10.41 11 111139 485 53237431
Electrocardiogram J wave abnormal 16.01 10.41 4 111146 9 53237907
Sciatica 16.00 10.41 13 111137 21680 53216236
Serositis 15.99 10.41 12 111138 611 53237305
Tooth infection 15.98 10.41 5 111145 14358 53223558
Hypoplastic left heart syndrome 15.91 10.41 8 111142 196 53237720
Poisoning deliberate 15.87 10.41 47 111103 8666 53229250
Colitis 15.70 10.41 40 111110 41512 53196404
Hepatic cirrhosis 15.70 10.41 9 111141 18013 53219903
Self-injurious ideation 15.62 10.41 22 111128 2374 53235542
Anaemia macrocytic 15.61 10.41 24 111126 2802 53235114
Drug dependence 15.61 10.41 87 111063 21385 53216531
Lipids abnormal 15.60 10.41 9 111141 292 53237624
Blister 15.59 10.41 98 111052 78655 53159261
Pancreatic injury 15.56 10.41 5 111145 35 53237881
Drug monitoring procedure incorrectly performed 15.54 10.41 7 111143 133 53237783
Lip erosion 15.53 10.41 14 111136 923 53236993
Tendonitis 15.53 10.41 8 111142 16998 53220918
Carnitine palmitoyltransferase deficiency 15.53 10.41 3 111147 0 53237916
Diabetic encephalopathy 15.53 10.41 3 111147 0 53237916
Congenital myopia 15.53 10.41 3 111147 0 53237916
Alpers disease 15.53 10.41 3 111147 0 53237916
Cryptorchism 15.53 10.41 3 111147 0 53237916
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.53 10.41 3 111147 0 53237916
Blood 1,25-dihydroxycholecalciferol decreased 15.53 10.41 3 111147 0 53237916
Congenital cutis laxa 15.53 10.41 3 111147 0 53237916
Mixed deafness 15.53 10.41 3 111147 0 53237916
Social (pragmatic) communication disorder 15.53 10.41 3 111147 0 53237916
Chorea 15.42 10.41 17 111133 1430 53236486
Prothrombin time shortened 15.38 10.41 19 111131 1805 53236111
Erythema multiforme 15.34 10.41 52 111098 10297 53227619
Memory impairment 15.32 10.41 255 110895 84502 53153414
Heart rate irregular 15.31 10.41 12 111138 20372 53217544
Drug level fluctuating 15.28 10.41 10 111140 408 53237508
Oral herpes 15.24 10.41 13 111137 21166 53216750
Diverticulum 15.24 10.41 3 111147 11776 53226140
Spine malformation 15.14 10.41 9 111141 309 53237607
Dysphoria 15.07 10.41 34 111116 5315 53232601
Prescribed overdose 15.03 10.41 63 111087 13796 53224120
Dysphagia 14.91 10.41 253 110897 84144 53153772
Electrocardiogram T wave inversion 14.88 10.41 27 111123 3612 53234304
Rectal haemorrhage 14.86 10.41 41 111109 41440 53196476
Therapeutic product effective for unapproved indication 14.85 10.41 6 111144 86 53237830
Ill-defined disorder 14.80 10.41 53 111097 49391 53188525
Sneezing 14.80 10.41 6 111144 14666 53223250
Crying 14.75 10.41 88 111062 22174 53215742
Emotional disorder 14.74 10.41 60 111090 12970 53224946
Syndactyly 14.71 10.41 9 111141 326 53237590
Bacteraemia 14.67 10.41 7 111143 15542 53222374
Incoherent 14.65 10.41 31 111119 4641 53233275
Decreased activity 14.64 10.41 34 111116 5417 53232499
Clonic convulsion 14.63 10.41 12 111138 696 53237220
Tubo-ovarian abscess 14.61 10.41 9 111141 330 53237586
Hepatomegaly 14.61 10.41 56 111094 11775 53226141
Poor personal hygiene 14.59 10.41 9 111141 331 53237585
Vascular encephalopathy 14.51 10.41 10 111140 445 53237471
Congenital nipple anomaly 14.50 10.41 4 111146 15 53237901
Live birth 14.46 10.41 66 111084 14993 53222923
Urine calcium/creatinine ratio increased 14.40 10.41 7 111143 159 53237757
Pulmonary valve stenosis congenital 14.36 10.41 7 111143 160 53237756
Breast cancer metastatic 14.31 10.41 7 111143 15321 53222595
Macular degeneration 14.31 10.41 4 111146 12357 53225559
Heterophoria 14.30 10.41 4 111146 16 53237900
Candida infection 14.29 10.41 19 111131 25254 53212662
Intestinal strangulation 14.26 10.41 6 111144 96 53237820
Grunting 14.26 10.41 8 111142 246 53237670
Hospitalisation 14.25 10.41 88 111062 70924 53166992
Seasonal allergy 14.24 10.41 7 111143 15278 53222638
Joint effusion 14.24 10.41 5 111145 13347 53224569
Joint range of motion decreased 14.22 10.41 10 111140 17946 53219970
Intervertebral disc degeneration 14.18 10.41 6 111144 14292 53223624
Plasmodium falciparum infection 14.18 10.41 5 111145 48 53237868
Oral candidiasis 14.16 10.41 11 111139 18762 53219154
Dyspepsia 14.14 10.41 99 111051 77501 53160415
Opisthotonus 14.14 10.41 9 111141 350 53237566
Acidosis 14.13 10.41 54 111096 11338 53226578
Electrocardiogram QRS complex shortened 14.10 10.41 10 111140 466 53237450
Hypoproteinaemia 14.10 10.41 19 111131 1967 53235949
Glaucoma 14.10 10.41 9 111141 16994 53220922
Amniocentesis abnormal 14.09 10.41 6 111144 99 53237817
Liver function test increased 14.08 10.41 21 111129 26607 53211309
Autonomic nervous system imbalance 14.04 10.41 22 111128 2612 53235304
Simple partial seizures 14.03 10.41 11 111139 598 53237318
Sinus disorder 13.98 10.41 11 111139 18643 53219273
Rib fracture 13.93 10.41 13 111137 20265 53217651
Ebstein's anomaly 13.92 10.41 4 111146 18 53237898
Colitis ulcerative 13.89 10.41 14 111136 21047 53216869
Gliosis 13.86 10.41 8 111142 260 53237656
Blood triglycerides increased 13.84 10.41 57 111093 12384 53225532
False positive investigation result 13.84 10.41 11 111139 610 53237306
Dry eye 13.81 10.41 31 111119 33613 53204303
Mucosal erosion 13.79 10.41 16 111134 1423 53236493
Shock 13.78 10.41 89 111061 23050 53214866
Copper deficiency 13.74 10.41 5 111145 53 53237863
Immunodeficiency 13.73 10.41 7 111143 14960 53222956
Withdrawal catatonia 13.65 10.41 5 111145 54 53237862
Congenital laryngeal stridor 13.65 10.41 5 111145 54 53237862
Septic shock 13.61 10.41 75 111075 62154 53175762
Gaucher's disease 13.58 10.41 4 111146 20 53237896
Deja vu 13.57 10.41 5 111145 55 53237861
Illness 13.54 10.41 16 111134 22380 53215536
Extensor plantar response 13.53 10.41 15 111135 1270 53236646
Suspected suicide attempt 13.51 10.41 6 111144 110 53237806
Rasmussen encephalitis 13.45 10.41 3 111147 3 53237913
Congenital inguinal hernia 13.45 10.41 3 111147 3 53237913
Blood pyruvic acid increased 13.45 10.41 3 111147 3 53237913
Asocial behaviour 13.45 10.41 3 111147 3 53237913
Tachypnoea 13.42 10.41 67 111083 15787 53222129
Infusion site pain 13.38 10.41 4 111146 11829 53226087
Medication error 13.36 10.41 125 111025 36240 53201676
Procedural pain 13.33 10.41 7 111143 14710 53223206
Sinus bradycardia 13.29 10.41 63 111087 14538 53223378
Coma hepatic 13.26 10.41 11 111139 648 53237268
Gallbladder disorder 13.26 10.41 11 111139 18154 53219762
Glassy eyes 13.26 10.41 5 111145 59 53237857
Mental disability 13.22 10.41 6 111144 116 53237800
Intestinal ischaemia 13.22 10.41 40 111110 7462 53230454
Hyperphagia 13.20 10.41 17 111133 1684 53236232
Skin discolouration 13.20 10.41 34 111116 35158 53202758
Dysphonia 13.20 10.41 44 111106 41894 53196022
Thought blocking 13.18 10.41 6 111144 117 53237799
Activated partial thromboplastin time abnormal 13.13 10.41 6 111144 118 53237798
Rash morbilliform 13.07 10.41 24 111126 3239 53234677
Posturing 13.07 10.41 10 111140 524 53237392
Sudden death 13.06 10.41 49 111101 10199 53227717
Drug ineffective 13.04 10.41 1916 109234 815329 52422587
Gastric disorder 13.04 10.41 27 111123 30138 53207778
Saccadic eye movement 13.03 10.41 5 111145 62 53237854
Childhood asthma 13.03 10.41 5 111145 62 53237854
Accidental poisoning 13.00 10.41 11 111139 666 53237250
Cortical visual impairment 12.99 10.41 3 111147 4 53237912
Quadriparesis 12.99 10.41 18 111132 1913 53236003
Amino acid level increased 12.95 10.41 8 111142 295 53237621
Bradypnoea 12.90 10.41 24 111126 3273 53234643
Blood urea decreased 12.85 10.41 20 111130 2360 53235556
Therapeutic product ineffective for unapproved indication 12.85 10.41 7 111143 203 53237713
Idiosyncratic drug reaction 12.74 10.41 12 111138 837 53237079
Coma acidotic 12.69 10.41 6 111144 128 53237788
Acute myeloid leukaemia 12.67 10.41 10 111140 16922 53220994
Device difficult to use 12.66 10.41 3 111147 10356 53227560
Hypoglycaemia neonatal 12.66 10.41 13 111137 1008 53236908
Cerebral palsy 12.64 10.41 6 111144 129 53237787
Lung disorder 12.62 10.41 54 111096 47825 53190091
Epileptic aura 12.55 10.41 5 111145 69 53237847
Generalised anxiety disorder 12.51 10.41 18 111132 1982 53235934
Oedema peripheral 12.47 10.41 266 110884 170521 53067395
High-pitched crying 12.44 10.41 4 111146 28 53237888
Otitis media 12.44 10.41 29 111121 4632 53233284
Tooth disorder 12.40 10.41 21 111129 25291 53212625
Injection site warmth 12.38 10.41 7 111143 14121 53223795
Homicidal ideation 12.34 10.41 17 111133 1797 53236119
Postictal state 12.29 10.41 13 111137 1043 53236873
Maternal exposure during breast feeding 12.29 10.41 24 111126 3393 53234523
Disorganised speech 12.28 10.41 13 111137 1044 53236872
Cell death 12.27 10.41 20 111130 2455 53235461
Congenital neurological disorder 12.24 10.41 3 111147 6 53237910
Regressive behaviour 12.23 10.41 5 111145 74 53237842
Blood sodium increased 12.22 10.41 21 111129 2691 53235225
Laboratory test abnormal 12.19 10.41 20 111130 24389 53213527
Upper gastrointestinal haemorrhage 12.18 10.41 11 111139 17419 53220497
Nodule 12.18 10.41 11 111139 17418 53220498
Blood citric acid increased 12.05 10.41 5 111145 77 53237839
Inhibitory drug interaction 12.03 10.41 19 111131 2271 53235645
Hyporesponsive to stimuli 12.01 10.41 13 111137 1071 53236845
Spinal fracture 12.01 10.41 10 111140 16475 53221441
Ligament laxity 12.00 10.41 6 111144 145 53237771
Malignant catatonia 11.98 10.41 4 111146 32 53237884
Joint hyperextension 11.97 10.41 7 111143 233 53237683
Anotia 11.93 10.41 3 111147 7 53237909
Fine motor delay 11.93 10.41 6 111144 147 53237769
Choreoathetosis 11.93 10.41 9 111141 462 53237454
Intervertebral disc protrusion 11.91 10.41 17 111133 21928 53215988
Pancreatitis haemorrhagic 11.89 10.41 8 111142 342 53237574
Respiratory tract congestion 11.89 10.41 8 111142 14691 53223225
Congenital eye disorder 11.87 10.41 4 111146 33 53237883
Anaphylactic shock 11.84 10.41 17 111133 21876 53216040
Myoglobinuria 11.79 10.41 7 111143 240 53237676
Brain stem syndrome 11.77 10.41 8 111142 348 53237568
Therapeutic response changed 11.77 10.41 12 111138 923 53236993
Congenital hypothyroidism 11.76 10.41 7 111143 241 53237675
Systemic inflammatory response syndrome 11.74 10.41 32 111118 5628 53232288
Toothache 11.71 10.41 12 111138 17902 53220014
Presyncope 11.71 10.41 23 111127 26171 53211745
Premature baby 11.69 10.41 76 111074 19725 53218191
Tooth development disorder 11.67 10.41 4 111146 35 53237881
Rash pruritic 11.65 10.41 59 111091 49951 53187965
Electrocardiogram J wave 11.65 10.41 3 111147 8 53237908
Magnetic resonance imaging head abnormal 11.61 10.41 17 111133 1901 53236015
Malignant melanoma 11.60 10.41 4 111146 10798 53227118
Hepatic steatosis 11.60 10.41 94 111056 26165 53211751
Eye swelling 11.58 10.41 17 111133 21677 53216239
Haemorrhage 11.56 10.41 72 111078 57915 53180001
Poverty of speech 11.55 10.41 8 111142 359 53237557
Tympanic membrane disorder 11.54 10.41 6 111144 158 53237758
Slow response to stimuli 11.51 10.41 12 111138 947 53236969
Viral infection 11.51 10.41 32 111118 32263 53205653
Congenital tracheomalacia 11.47 10.41 4 111146 37 53237879
Developmental coordination disorder 11.47 10.41 4 111146 37 53237879
Metastases to lung 11.46 10.41 5 111145 11699 53226217
Acne 11.44 10.41 17 111133 21569 53216347
Blood bicarbonate increased 11.42 10.41 11 111139 789 53237127
Ageusia 11.42 10.41 6 111144 12608 53225308
Alanine aminotransferase increased 11.41 10.41 269 110881 94826 53143090
Congenital gastric anomaly 11.39 10.41 3 111147 9 53237907
Congenital floppy infant 11.39 10.41 3 111147 9 53237907
Head circumference abnormal 11.39 10.41 3 111147 9 53237907
Post-anoxic myoclonus 11.38 10.41 4 111146 38 53237878
Postictal paralysis 11.34 10.41 5 111145 90 53237826
Creatinine renal clearance decreased 11.34 10.41 4 111146 10647 53227269
Osteonecrosis 11.31 10.41 24 111126 26551 53211365
Sinus tachycardia 11.30 10.41 86 111064 23486 53214430
Thermal burn 11.27 10.41 30 111120 5203 53232713
Mobility decreased 11.26 10.41 103 111047 76168 53161748
Hydrocephalus 11.26 10.41 30 111120 5206 53232710
Knee deformity 11.26 10.41 12 111138 972 53236944
Blood osmolarity increased 11.17 10.41 6 111144 169 53237747
Intention tremor 11.17 10.41 8 111142 379 53237537
Neonatal disorder 11.16 10.41 10 111140 654 53237262
Maternal drugs affecting foetus 11.15 10.41 31 111119 5515 53232401
Faecal vomiting 11.11 10.41 10 111140 658 53237258
Rotator cuff syndrome 11.09 10.41 6 111144 12399 53225517
Skin disorder 11.08 10.41 22 111128 24936 53212980
Gout 11.08 10.41 6 111144 12393 53225523
Reproductive tract disorder 11.07 10.41 6 111144 172 53237744
Oppositional defiant disorder 11.02 10.41 4 111146 42 53237874
Aura 11.01 10.41 12 111138 997 53236919
Exostosis 11.00 10.41 5 111145 11419 53226497
Deep vein thrombosis 10.97 10.41 115 111035 82798 53155118
Cleft uvula 10.93 10.41 3 111147 11 53237905
Congenital oesophageal anomaly 10.93 10.41 3 111147 11 53237905
Procalcitonin increased 10.87 10.41 11 111139 838 53237078
Antidepressant drug level increased 10.82 10.41 7 111143 280 53237636
Eosinophilic myocarditis 10.79 10.41 8 111142 400 53237516
Encapsulating peritoneal sclerosis 10.73 10.41 8 111142 403 53237513
Congenital nail disorder 10.73 10.41 5 111145 103 53237813
Toe walking 10.72 10.41 3 111147 12 53237904
Type 2 diabetes mellitus 10.72 10.41 107 111043 31563 53206353
Persistent left superior vena cava 10.70 10.41 4 111146 46 53237870
Hernia 10.67 10.41 4 111146 10256 53227660
Hyperaldosteronism 10.67 10.41 7 111143 287 53237629
Delusional disorder, unspecified type 10.66 10.41 8 111142 407 53237509
Tongue biting 10.62 10.41 14 111136 1419 53236497
Therapy interrupted 10.60 10.41 15 111135 19421 53218495
Delusion of reference 10.60 10.41 5 111145 106 53237810
Glioblastoma multiforme 10.58 10.41 11 111139 865 53237051
Febrile convulsion 10.56 10.41 8 111142 413 53237503
Scar excision 10.54 10.41 4 111146 48 53237868
Neutrophilia 10.51 10.41 23 111127 3522 53234394
Transplant rejection 10.49 10.41 4 111146 10147 53227769
Histiocytic necrotising lymphadenitis 10.47 10.41 4 111146 49 53237867
Thyroglobulin increased 10.47 10.41 4 111146 49 53237867
Nikolsky's sign 10.43 10.41 5 111145 110 53237806
Burning sensation 10.43 10.41 58 111092 47955 53189961
Carpal tunnel syndrome 10.42 10.41 13 111137 17754 53220162

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1855.60 11.48 2110 119911 101744 32289761
Hyperammonaemia 1176.59 11.48 532 121489 5437 32386068
Foetal anticonvulsant syndrome 913.50 11.48 279 121742 772 32390733
Epilepsy 888.03 11.48 705 121316 21404 32370101
Drug interaction 872.17 11.48 2270 119751 215915 32175590
Dysmorphism 829.59 11.48 333 121688 2460 32389045
Aggression 788.44 11.48 851 121170 38538 32352967
Hyperammonaemic encephalopathy 742.43 11.48 283 121738 1788 32389717
Neuroleptic malignant syndrome 726.41 11.48 569 121452 16926 32374579
Status epilepticus 706.18 11.48 482 121539 11524 32379981
Foetal exposure during pregnancy 563.81 11.48 734 121287 40567 32350938
Autism spectrum disorder 536.90 11.48 218 121803 1664 32389841
Somnolence 521.02 11.48 1181 120840 102616 32288889
Speech disorder developmental 462.35 11.48 192 121829 1562 32389943
Generalised tonic-clonic seizure 439.34 11.48 461 121560 20178 32371327
Dyspnoea 421.58 11.48 444 121577 361601 32029904
Mania 414.30 11.48 320 121701 9312 32382193
Ammonia increased 392.05 11.48 231 121790 4233 32387272
Developmental delay 390.97 11.48 193 121828 2435 32389070
Abnormal behaviour 382.44 11.48 484 121537 25982 32365523
Diarrhoea 367.54 11.48 501 121520 364301 32027204
Sopor 362.63 11.48 322 121699 11427 32380078
Agitation 359.46 11.48 714 121307 56522 32334983
Psychotic disorder 353.43 11.48 434 121587 22586 32368919
Sedation 331.94 11.48 378 121643 18148 32373357
Psychomotor retardation 324.51 11.48 177 121844 2778 32388727
Granulocytopenia 321.42 11.48 235 121786 6280 32385225
Extrapyramidal disorder 320.27 11.48 302 121719 11593 32379912
Parkinsonism 320.16 11.48 253 121768 7616 32383889
Learning disorder 317.72 11.48 120 121901 736 32390769
Intellectual disability 305.50 11.48 127 121894 1036 32390469
Cognitive disorder 299.72 11.48 425 121596 25469 32366036
Death 284.43 11.48 636 121385 381881 32009624
Febrile neutropenia 272.68 11.48 58 121963 119508 32271997
Toxicity to various agents 268.85 11.48 1349 120672 176692 32214813
Language disorder 257.50 11.48 132 121889 1813 32389692
Arthralgia 256.76 11.48 118 121903 148330 32243175
Coma 254.80 11.48 521 121500 42091 32349414
Schizophrenia 250.81 11.48 244 121777 9740 32381765
Acute kidney injury 244.09 11.48 457 121564 293011 32098494
Petit mal epilepsy 243.47 11.48 146 121875 2766 32388739
Congenital nose malformation 235.71 11.48 67 121954 130 32391375
Depression 235.50 11.48 850 121171 96210 32295295
Nausea 227.29 11.48 547 121474 320302 32071203
Fatigue 224.69 11.48 629 121392 350072 32041433
Hypospadias 224.33 11.48 140 121881 2857 32388648
Antipsychotic drug level increased 224.31 11.48 149 121872 3397 32388108
Salivary hypersecretion 222.80 11.48 208 121813 7880 32383625
Intentional overdose 221.31 11.48 485 121536 41116 32350389
Psychomotor skills impaired 218.41 11.48 129 121892 2374 32389131
Irritability 216.50 11.48 356 121665 24298 32367207
Intentional self-injury 216.43 11.48 264 121757 13636 32377869
Attention deficit hyperactivity disorder 214.24 11.48 122 121899 2090 32389415
Behaviour disorder 214.20 11.48 146 121875 3478 32388027
Disturbance in attention 214.02 11.48 347 121674 23406 32368099
Anaemia 207.02 11.48 325 121696 223299 32168206
Myocardial infarction 206.47 11.48 107 121914 125569 32265936
Drug level decreased 205.54 11.48 180 121841 6266 32385239
Drug level increased 199.79 11.48 307 121714 19773 32371732
Atrial fibrillation 195.24 11.48 97 121924 116607 32274898
Psychomotor hyperactivity 194.23 11.48 203 121818 8836 32382669
Mental impairment 192.52 11.48 212 121809 9800 32381705
Ataxia 190.33 11.48 237 121784 12504 32379001
Akathisia 182.69 11.48 175 121846 6850 32384655
Pain 181.79 11.48 264 121757 187292 32204213
Suicide attempt 181.31 11.48 426 121595 37818 32353687
Overdose 180.16 11.48 725 121296 86352 32305153
Cardiac failure congestive 179.92 11.48 48 121973 84804 32306701
Dysgraphia 179.23 11.48 104 121917 1849 32389656
Speech disorder 178.66 11.48 339 121682 25914 32365591
Tremor 178.06 11.48 689 121332 80588 32310917
Hypertelorism 175.72 11.48 69 121952 477 32391028
Plasma cell myeloma 175.66 11.48 10 122011 57604 32333901
Electroencephalogram abnormal 167.20 11.48 110 121911 2466 32389039
Blood creatine phosphokinase increased 167.10 11.48 460 121561 45016 32346489
Gastrointestinal haemorrhage 163.10 11.48 61 121960 86821 32304684
Pneumonia 162.03 11.48 735 121286 354517 32036988
Multiple-drug resistance 161.39 11.48 125 121896 3650 32387855
Anticonvulsant drug level increased 160.27 11.48 89 121932 1449 32390056
Depressed level of consciousness 159.94 11.48 423 121598 40424 32351081
Neuropathy peripheral 158.63 11.48 46 121975 76936 32314569
Hallucination, auditory 158.57 11.48 195 121826 10155 32381350
Partial seizures 157.24 11.48 128 121893 4022 32387483
Pain in extremity 156.31 11.48 130 121891 118771 32272734
Dystonia 152.93 11.48 194 121827 10429 32381076
Antipsychotic drug level below therapeutic 152.48 11.48 94 121927 1875 32389630
Anticonvulsant drug level decreased 147.29 11.48 73 121948 929 32390576
Catatonia 147.17 11.48 130 121891 4578 32386927
Product residue present 146.63 11.48 105 121916 2713 32388792
Delusion 145.54 11.48 211 121810 12897 32378608
Astigmatism 142.27 11.48 71 121950 918 32390587
Hypotonia 141.31 11.48 159 121862 7528 32383977
Muscle rigidity 138.94 11.48 190 121831 10996 32380509
Product substitution issue 136.84 11.48 182 121839 10254 32381251
Interstitial lung disease 135.46 11.48 38 121983 64963 32326542
Motor developmental delay 135.23 11.48 57 121964 483 32391022
Malignant neoplasm progression 131.58 11.48 65 121956 78431 32313074
Neurodevelopmental disorder 131.23 11.48 42 121979 142 32391363
Tardive dyskinesia 131.15 11.48 131 121890 5400 32386105
Enuresis 129.68 11.48 87 121934 2017 32389488
Schizoaffective disorder 128.99 11.48 73 121948 1235 32390270
Wrong patient received product 128.71 11.48 92 121929 2370 32389135
Disease progression 128.32 11.48 84 121937 86778 32304727
Lip disorder 128.02 11.48 51 121970 368 32391137
Asthenia 123.01 11.48 463 121558 235481 32156024
Euphoric mood 122.47 11.48 123 121898 5104 32386401
Bipolar disorder 122.38 11.48 108 121913 3798 32387707
Paranoia 121.59 11.48 175 121846 10624 32380881
Renal failure 120.88 11.48 199 121822 134279 32257226
Delirium 120.78 11.48 402 121619 43644 32347861
Dyspraxia 120.59 11.48 46 121975 291 32391214
Encephalopathy 120.38 11.48 341 121680 33916 32357589
Dyskinesia 118.52 11.48 269 121752 23334 32368171
Mental disorder 118.27 11.48 203 121818 14345 32377160
Congenital oral malformation 116.49 11.48 26 121995 3 32391502
Myopia 116.40 11.48 60 121961 834 32390671
Dysarthria 116.19 11.48 330 121691 32871 32358634
Joint swelling 116.00 11.48 26 121995 51709 32339796
Chest pain 115.04 11.48 180 121841 123957 32267548
Treatment noncompliance 115.01 11.48 290 121731 26912 32364593
Foot deformity 114.66 11.48 106 121915 3964 32387541
Cough 114.30 11.48 217 121804 138600 32252905
Peripheral swelling 113.93 11.48 57 121964 68288 32323217
Skull malformation 112.88 11.48 47 121974 385 32391120
Priapism 112.47 11.48 115 121906 4876 32386629
Talipes 111.80 11.48 76 121945 1802 32389703
Cryptorchism 109.77 11.48 76 121945 1858 32389647
Drug reaction with eosinophilia and systemic symptoms 108.95 11.48 318 121703 32167 32359338
Sudden unexplained death in epilepsy 108.86 11.48 47 121974 425 32391080
Myocarditis 106.66 11.48 171 121850 11419 32380086
Focal dyscognitive seizures 106.35 11.48 65 121956 1276 32390229
Myoclonic epilepsy 105.77 11.48 58 121963 920 32390585
Hypotonia neonatal 105.63 11.48 62 121959 1127 32390378
Strabismus 105.30 11.48 66 121955 1357 32390148
Altered state of consciousness 105.27 11.48 246 121775 21751 32369754
Pruritus 105.24 11.48 202 121819 128500 32263005
Thrombosis 104.60 11.48 22 121999 45732 32345773
Limb malformation 104.15 11.48 47 121974 477 32391028
Infusion related reaction 104.09 11.48 22 121999 45577 32345928
Restlessness 102.84 11.48 263 121758 24618 32366887
Obsessive-compulsive disorder 102.77 11.48 109 121912 4825 32386680
Learning disability 102.73 11.48 39 121982 243 32391262
Bradyphrenia 101.31 11.48 105 121916 4524 32386981
Back pain 101.02 11.48 163 121858 110890 32280615
Drug level below therapeutic 100.65 11.48 100 121921 4095 32387410
Anticonvulsant drug level below therapeutic 100.45 11.48 49 121972 601 32390904
Cardiac failure 99.98 11.48 118 121903 91555 32299950
Thinking abnormal 99.24 11.48 114 121907 5521 32385984
Coronary artery disease 98.23 11.48 32 121989 49674 32341831
Disinhibition 97.00 11.48 81 121940 2639 32388866
Communication disorder 96.43 11.48 79 121942 2505 32389000
Oedema peripheral 95.96 11.48 176 121845 113915 32277590
Myalgia 95.81 11.48 98 121923 81132 32310373
Joint laxity 95.70 11.48 37 121984 244 32391261
Congenital foot malformation 95.06 11.48 37 121984 249 32391256
Low set ears 95.03 11.48 42 121979 404 32391101
Myoclonus 94.71 11.48 185 121836 14444 32377061
Suicidal ideation 94.29 11.48 336 121685 37747 32353758
Psoriasis 94.18 11.48 28 121993 46095 32345410
Abdominal pain 93.26 11.48 271 121750 149258 32242247
Coordination abnormal 92.31 11.48 129 121892 7619 32383886
Acute myocardial infarction 91.90 11.48 46 121975 55103 32336402
Disorientation 90.67 11.48 304 121717 33121 32358384
Fanconi syndrome 90.55 11.48 66 121955 1754 32389751
Sepsis 90.47 11.48 300 121721 158534 32232971
Drooling 89.28 11.48 84 121937 3213 32388292
Educational problem 88.93 11.48 41 121980 439 32391066
Dizziness 86.35 11.48 449 121572 209169 32182336
Anticonvulsant drug level above therapeutic 86.33 11.48 41 121980 472 32391033
Psychogenic seizure 86.24 11.48 37 121984 329 32391176
Antipsychotic drug level above therapeutic 86.08 11.48 54 121967 1112 32390393
Pectus excavatum 86.02 11.48 31 121990 163 32391342
Prominent epicanthal folds 85.14 11.48 30 121991 146 32391359
Drug ineffective 85.08 11.48 1958 120063 381519 32009986
Neutrophil count increased 84.64 11.48 187 121834 15927 32375578
Hyperkalaemia 83.56 11.48 83 121938 69667 32321838
Ear disorder 83.40 11.48 54 121967 1177 32390328
Ligament laxity 82.43 11.48 20 122001 12 32391493
Fine motor delay 82.26 11.48 32 121989 215 32391290
Congenital hand malformation 80.50 11.48 40 121981 512 32390993
Asterixis 80.11 11.48 54 121967 1262 32390243
Hypermetropia 79.63 11.48 36 121985 367 32391138
Hypothermia 79.53 11.48 139 121882 9964 32381541
Hypertonia 79.20 11.48 94 121927 4715 32386790
Chest discomfort 79.13 11.48 45 121976 50185 32341320
Oppositional defiant disorder 79.13 11.48 39 121982 490 32391015
Increased appetite 78.91 11.48 109 121912 6367 32385138
Hypernatraemia 77.86 11.48 123 121898 8110 32383395
Disturbance in social behaviour 77.49 11.48 58 121963 1607 32389898
Chills 77.38 11.48 108 121913 77976 32313529
Affect lability 77.01 11.48 82 121939 3646 32387859
Clinodactyly 76.96 11.48 31 121990 231 32391274
Completed suicide 76.77 11.48 602 121419 91915 32299590
Pneumonia aspiration 76.64 11.48 332 121689 40824 32350681
Mucosal inflammation 76.57 11.48 16 122005 33418 32358087
Headache 76.50 11.48 428 121593 195769 32195736
Antipsychotic drug level decreased 76.21 11.48 46 121975 882 32390623
Drug withdrawal convulsions 75.91 11.48 50 121971 1123 32390382
Scoliosis 75.21 11.48 64 121957 2141 32389364
Echolalia 75.12 11.48 30 121991 218 32391287
Anger 73.99 11.48 148 121873 11756 32379749
Pulmonary embolism 73.99 11.48 125 121896 83534 32307971
Dyspnoea exertional 73.67 11.48 27 121994 38934 32352571
Developmental coordination disorder 73.22 11.48 26 121995 130 32391375
Blood pressure increased 72.57 11.48 116 121905 79238 32312267
Bipolar I disorder 72.51 11.48 44 121977 852 32390653
Congenital anomaly 72.13 11.48 52 121969 1358 32390147
Prostate cancer 71.96 11.48 9 122012 27397 32364108
Renal impairment 71.15 11.48 149 121872 91823 32299682
Persecutory delusion 69.96 11.48 63 121958 2276 32389229
Impulsive behaviour 69.53 11.48 61 121960 2128 32389377
Prescribed overdose 68.58 11.48 126 121895 9393 32382112
Eosinophilia 68.57 11.48 228 121793 24730 32366775
Hypomania 68.36 11.48 63 121958 2346 32389159
Oculogyric crisis 68.36 11.48 51 121970 1406 32390099
Dysphoria 66.67 11.48 61 121960 2250 32389255
Stevens-Johnson syndrome 66.45 11.48 187 121834 18522 32372983
Obesity 66.19 11.48 129 121892 10053 32381452
White blood cell count increased 65.95 11.48 319 121702 41083 32350422
Influenza 65.90 11.48 46 121975 45968 32345537
Cerebrovascular accident 65.80 11.48 141 121880 86179 32305326
Microcephaly 65.67 11.48 39 121982 725 32390780
Nystagmus 65.30 11.48 84 121937 4578 32386927
Infantile spasms 65.16 11.48 29 121992 284 32391221
Musculoskeletal pain 63.96 11.48 20 122001 31877 32359628
Therapeutic product effect variable 63.76 11.48 57 121964 2039 32389466
Ascites 63.31 11.48 36 121985 40155 32351350
Weight increased 63.24 11.48 533 121488 83130 32308375
Urticaria 62.58 11.48 79 121942 59535 32331970
Dehydration 62.01 11.48 261 121760 128697 32262808
Epistaxis 61.83 11.48 71 121950 55784 32335721
Muscle spasms 61.54 11.48 106 121915 70312 32321193
Ear malformation 60.88 11.48 28 121993 298 32391207
Decreased eye contact 60.70 11.48 32 121989 467 32391038
Fluid retention 60.20 11.48 13 122008 26537 32364968
Craniosynostosis 60.15 11.48 28 121993 307 32391198
Nasal disorder 59.12 11.48 48 121973 1502 32390003
Brain oedema 58.82 11.48 142 121879 12818 32378687
Weight decreased 58.67 11.48 370 121651 164448 32227057
Fine motor skill dysfunction 58.35 11.48 49 121972 1609 32389896
Pressure of speech 58.12 11.48 31 121990 464 32391041
Dyslexia 57.93 11.48 27 121994 297 32391208
Stereotypy 57.80 11.48 35 121986 675 32390830
Exposure during pregnancy 57.67 11.48 115 121906 9114 32382391
Melaena 57.61 11.48 29 121992 34636 32356869
Angina pectoris 57.38 11.48 23 121998 31403 32360102
Serotonin syndrome 57.36 11.48 180 121841 18937 32372568
Abdominal pain upper 57.36 11.48 103 121918 67235 32324270
Atonic seizures 57.26 11.48 23 121998 170 32391335
Hypersensitivity 57.10 11.48 80 121941 57678 32333827
Sleep disorder 57.03 11.48 225 121796 26527 32364978
Stupor 56.60 11.48 63 121958 2946 32388559
Confusional state 56.53 11.48 801 121220 142314 32249191
Blood creatinine increased 56.46 11.48 179 121842 95953 32295552
Differential white blood cell count abnormal 56.12 11.48 44 121977 1308 32390197
Drug abuse 55.84 11.48 502 121519 79741 32311764
Asocial behaviour 55.14 11.48 17 122004 49 32391456
Psychotic symptom 55.00 11.48 45 121976 1424 32390081
Erythema 54.42 11.48 147 121874 82958 32308547
Physical assault 54.27 11.48 40 121981 1082 32390423
Pancytopenia 54.20 11.48 169 121852 91066 32300439
Osteonecrosis of jaw 53.62 11.48 5 122016 19161 32372344
Upper gastrointestinal haemorrhage 53.42 11.48 12 122009 23837 32367668
Personality disorder 53.32 11.48 41 121980 1184 32390321
Personal relationship issue 53.14 11.48 24 121997 244 32391261
Hypoaesthesia 52.68 11.48 86 121935 58267 32333238
Plagiocephaly 52.46 11.48 27 121994 374 32391131
Herpes zoster 52.34 11.48 28 121993 32313 32359192
Septic shock 52.31 11.48 113 121908 68876 32322629
Psychiatric symptom 52.30 11.48 66 121955 3528 32387977
Congenital eye disorder 52.10 11.48 19 122002 104 32391401
Hypermobility syndrome 52.04 11.48 26 121995 337 32391168
General physical health deterioration 51.93 11.48 239 121782 115020 32276485
Congenital eyelid malformation 51.42 11.48 16 122005 48 32391457
Chronic kidney disease 50.88 11.48 45 121976 39930 32351575
Atrial septal defect 50.62 11.48 93 121928 6932 32384573
Urinary incontinence 50.61 11.48 167 121854 18040 32373465
Sinusitis 50.46 11.48 38 121983 36522 32354983
Sedation complication 50.22 11.48 39 121982 1143 32390362
Bruxism 50.05 11.48 45 121976 1622 32389883
Syncope 50.03 11.48 172 121849 89952 32301553
Mental status changes 49.72 11.48 279 121742 38058 32353447
Arthritis 49.61 11.48 19 122002 26673 32364832
Drug level changed 49.57 11.48 25 121996 331 32391174
Bradykinesia 49.04 11.48 70 121951 4216 32387289
Anaphylactic reaction 49.01 11.48 26 121995 30146 32361359
Camptodactyly congenital 48.97 11.48 15 122006 42 32391463
Gait disturbance 48.96 11.48 489 121532 79919 32311586
Motor dysfunction 48.08 11.48 87 121934 6409 32385096
Blood prolactin increased 47.55 11.48 43 121978 1562 32389943
Leukopenia 47.53 11.48 387 121634 59735 32331770
Eosinophilic pleural effusion 47.44 11.48 22 121999 239 32391266
Normal pressure hydrocephalus 47.24 11.48 19 122002 141 32391364
Homicidal ideation 46.82 11.48 54 121967 2626 32388879
Toxic encephalopathy 46.57 11.48 74 121947 4903 32386602
Nose deformity 46.56 11.48 19 122002 147 32391358
Haematochezia 46.55 11.48 47 121974 39161 32352344
Respiratory failure 46.08 11.48 226 121795 106956 32284549
Haemoptysis 46.07 11.48 35 121986 33490 32358015
Diabetes insipidus 45.93 11.48 53 121968 2579 32388926
Congenital hair disorder 45.89 11.48 10 122011 0 32391505
Gaze palsy 45.42 11.48 39 121982 1321 32390184
Hyperacusis 45.41 11.48 31 121990 740 32390765
Multiple congenital abnormalities 45.13 11.48 27 121994 509 32390996
Lethargy 45.11 11.48 287 121734 40941 32350564
Hyperosmolar state 44.96 11.48 25 121996 408 32391097
Hyperprolactinaemia 44.43 11.48 38 121983 1280 32390225
Cytomegalovirus infection 44.31 11.48 20 122001 25444 32366061
Rectal haemorrhage 44.27 11.48 45 121976 37378 32354127
Psoriatic arthropathy 44.23 11.48 7 122014 17853 32373652
Arthropathy 43.51 11.48 15 122006 22474 32369031
Pneumonitis 43.31 11.48 30 121991 30104 32361401
Pneumocystis jirovecii pneumonia 43.27 11.48 9 122012 18861 32372644
Basal cell carcinoma 43.25 11.48 7 122014 17561 32373944
Swelling 42.93 11.48 48 121973 38174 32353331
Spina bifida 42.61 11.48 23 121998 353 32391152
Arnold-Chiari malformation 42.48 11.48 22 121999 309 32391196
Cerebellar atrophy 42.47 11.48 25 121996 457 32391048
Social avoidant behaviour 42.25 11.48 56 121965 3143 32388362
Knee deformity 42.15 11.48 26 121995 519 32390986
Paraesthesia 41.88 11.48 100 121921 58844 32332661
Palmar-plantar erythrodysaesthesia syndrome 41.77 11.48 5 122016 15744 32375761
Hyperkinesia 41.59 11.48 47 121974 2235 32389270
High arched palate 41.54 11.48 14 122007 58 32391447
Acidosis hyperchloraemic 41.51 11.48 21 122000 280 32391225
Homicide 41.11 11.48 32 121989 941 32390564
Choreoathetosis 41.05 11.48 33 121988 1018 32390487
Malaise 40.96 11.48 446 121575 176692 32214813
Rash 40.83 11.48 547 121474 208786 32182719
Seizure cluster 40.70 11.48 16 122005 111 32391394
Cerebral atrophy 40.57 11.48 66 121955 4461 32387044
Monocyte count increased 40.20 11.48 61 121960 3883 32387622
Abdominal discomfort 40.05 11.48 86 121935 52538 32338967
Cerebral ventricle dilatation 39.82 11.48 31 121990 912 32390593
Cogwheel rigidity 39.66 11.48 36 121985 1314 32390191
Chorea 39.60 11.48 33 121988 1072 32390433
Lung disorder 39.46 11.48 41 121980 33713 32357792
Loss of personal independence in daily activities 39.36 11.48 202 121819 26631 32364874
Reading disorder 39.33 11.48 23 121998 415 32391090
Anisometropia 39.33 11.48 13 122008 50 32391455
Cytokine release syndrome 39.32 11.48 3 122018 13532 32377973
Full blood count decreased 39.24 11.48 8 122013 17002 32374503
Encopresis 38.41 11.48 15 122006 102 32391403
Pancreatitis 38.35 11.48 260 121761 37891 32353614
Nipple disorder 38.07 11.48 18 122003 205 32391300
Ear infection 37.73 11.48 92 121929 8356 32383149
Delusional disorder, unspecified type 37.56 11.48 28 121993 771 32390734
Dyscalculia 37.53 11.48 11 122010 25 32391480
Stomatitis 37.53 11.48 58 121963 40171 32351334
Haemorrhage 37.47 11.48 81 121940 49367 32342138
Eosinophil count decreased 37.28 11.48 34 121987 1249 32390256
Congenital musculoskeletal anomaly 37.25 11.48 19 122002 258 32391247
Autonomic nervous system imbalance 37.23 11.48 47 121974 2513 32388992
Postictal paralysis 37.21 11.48 17 122004 178 32391327
Logorrhoea 37.08 11.48 46 121975 2416 32389089
Faecaloma 36.87 11.48 65 121956 4691 32386814
Necrosis ischaemic 36.81 11.48 18 122003 222 32391283
Congenital myopia 36.78 11.48 10 122011 15 32391490
Acute myeloid leukaemia 36.73 11.48 13 122008 19161 32372344
Carnitine decreased 36.71 11.48 8 122013 0 32391505
Affective disorder 36.51 11.48 55 121966 3478 32388027
Excessive eye blinking 36.48 11.48 22 121999 421 32391084
Apathy 36.48 11.48 79 121942 6636 32384869
Dysmetria 36.15 11.48 21 122000 374 32391131
Pleurothotonus 36.10 11.48 31 121990 1050 32390455
Dysgeusia 35.92 11.48 26 121995 25505 32366000
Hypotension 35.79 11.48 583 121438 215527 32175978
Congenital nail disorder 35.60 11.48 11 122010 32 32391473
Coma scale abnormal 35.42 11.48 55 121966 3572 32387933
Brugada syndrome 35.41 11.48 26 121995 699 32390806
Angioedema 35.13 11.48 51 121970 36238 32355267
Tooth malformation 35.10 11.48 15 122006 132 32391373
COVID-19 35.09 11.48 41 121980 31974 32359531
Renal disorder 34.97 11.48 26 121995 25157 32366348
Neoplasm progression 34.90 11.48 15 122006 19643 32371862
Flight of ideas 34.64 11.48 20 122001 352 32391153
Haematuria 34.39 11.48 82 121939 48279 32343226
Lymphocyte count increased 34.27 11.48 47 121974 2726 32388779
International normalised ratio increased 34.19 11.48 84 121937 48951 32342554
Pancreatitis acute 34.17 11.48 197 121824 27138 32364367
Transient ischaemic attack 34.09 11.48 28 121993 25766 32365739
Gastrointestinal malformation 33.97 11.48 11 122010 39 32391466
Coloboma 33.96 11.48 15 122006 144 32391361
Crying 33.91 11.48 71 121950 5825 32385680
Bacteraemia 33.70 11.48 12 122009 17621 32373884
Mood altered 33.60 11.48 91 121930 8813 32382692
Colitis 33.57 11.48 47 121974 33904 32357601
Delusion of grandeur 33.54 11.48 21 122000 431 32391074
Osteoarthritis 33.51 11.48 16 122005 19703 32371802
Oedema 33.35 11.48 75 121946 45072 32346433
Distractibility 33.28 11.48 19 122002 327 32391178
Tumour lysis syndrome 33.23 11.48 7 122014 14540 32376965
Drop attacks 33.05 11.48 23 121998 567 32390938
Emotional disorder 33.04 11.48 67 121954 5374 32386131
Staphylococcal infection 32.99 11.48 44 121977 32395 32359110
Anaphylactic shock 32.80 11.48 8 122013 15026 32376479
Bronchopulmonary aspergillosis 32.49 11.48 6 122015 13681 32377824
Soliloquy 32.48 11.48 20 122001 398 32391107
Nasal septum disorder 32.37 11.48 11 122010 47 32391458
Bone pain 32.35 11.48 18 122003 20326 32371179
Arachnodactyly 32.26 11.48 8 122013 6 32391499
Intelligence test abnormal 32.17 11.48 9 122012 16 32391489
Confabulation 32.10 11.48 14 122007 130 32391375
Postictal psychosis 32.10 11.48 14 122007 130 32391375
Anion gap increased 31.97 11.48 36 121985 1705 32389800
Pneumothorax 31.84 11.48 13 122008 17557 32373948
Retinal coloboma 31.82 11.48 9 122012 17 32391488
Deep vein thrombosis 31.80 11.48 127 121894 63586 32327919
Injection site pain 31.47 11.48 47 121974 33011 32358494
Atrial flutter 31.38 11.48 9 122012 15174 32376331
Chronic obstructive pulmonary disease 31.33 11.48 87 121934 48666 32342839
Congenital astigmatism 31.16 11.48 9 122012 19 32391486
Haemoglobin decreased 31.07 11.48 293 121728 119378 32272127
Inappropriate affect 31.00 11.48 22 121999 560 32390945
Flushing 30.87 11.48 43 121978 31084 32360421
Postictal state 30.77 11.48 25 121996 783 32390722
Tonic convulsion 30.74 11.48 27 121994 943 32390562
Product dose omission issue 30.71 11.48 242 121779 102333 32289172
Decreased appetite 30.68 11.48 422 121599 160391 32231114
Perseveration 30.65 11.48 13 122008 112 32391393
Sexually inappropriate behaviour 30.56 11.48 20 122001 444 32391061
Congenital knee deformity 30.55 11.48 13 122008 113 32391392
Prognathism 30.34 11.48 11 122010 59 32391446
Inappropriate antidiuretic hormone secretion 30.32 11.48 107 121914 11956 32379549
Fluid overload 30.29 11.48 18 122003 19603 32371902
Angina unstable 30.24 11.48 5 122016 12350 32379155
Laboratory test abnormal 30.19 11.48 17 122004 19070 32372435
Pharyngeal disorder 30.14 11.48 22 121999 586 32390919
Convulsive threshold lowered 30.13 11.48 21 122000 519 32390986
Synovitis 30.00 11.48 3 122018 10875 32380630
Hypokalaemia 29.98 11.48 106 121915 54988 32336517
Dacryostenosis congenital 29.97 11.48 9 122012 23 32391482
Illiteracy 29.83 11.48 8 122013 11 32391494
Heart disease congenital 29.75 11.48 31 121990 1344 32390161
Apraxia 29.74 11.48 30 121991 1251 32390254
Memory impairment 29.56 11.48 256 121765 40223 32351282
Antisocial behaviour 29.35 11.48 17 122004 301 32391204
Acute coronary syndrome 29.30 11.48 8 122013 13933 32377572
Medication error 29.21 11.48 164 121857 22371 32369134
Developmental hip dysplasia 29.21 11.48 17 122004 304 32391201
Anxiety 29.01 11.48 514 121507 95491 32296014
Hepatic adenoma 29.01 11.48 10 122011 45 32391460
Night sweats 29.00 11.48 12 122009 16076 32375429
Anticonvulsant drug level abnormal 28.93 11.48 9 122012 27 32391478
Metabolic syndrome 28.76 11.48 33 121988 1596 32389909
Myelodysplastic syndrome 28.73 11.48 20 122001 20018 32371487
Torticollis 28.45 11.48 28 121993 1133 32390372
Emotional disorder of childhood 28.45 11.48 9 122012 29 32391476
Posture abnormal 28.37 11.48 38 121983 2155 32389350
Pelvic deformity 28.32 11.48 8 122013 15 32391490
Nasopharyngitis 28.27 11.48 133 121888 63654 32327851
Bronchiolitis 28.21 11.48 44 121977 2869 32388636
Eosinophil count increased 28.20 11.48 82 121939 8273 32383232
Bladder cancer 27.84 11.48 3 122018 10253 32381252
Hypotelorism of orbit 27.75 11.48 12 122009 109 32391396
Dyslipidaemia 27.65 11.48 72 121949 6811 32384694
Meningocele 27.56 11.48 9 122012 33 32391472
Factor XIII deficiency 27.53 11.48 6 122015 0 32391505
Toe walking 27.53 11.48 6 122015 0 32391505
Mutism 27.34 11.48 23 121998 757 32390748
Executive dysfunction 27.20 11.48 14 122007 194 32391311
Muscle tone disorder 27.20 11.48 13 122008 152 32391353
Intensive care unit acquired weakness 27.19 11.48 25 121996 928 32390577
Renal injury 27.13 11.48 6 122015 12049 32379456
Cellulitis 27.09 11.48 97 121924 50133 32341372
Cleft palate 27.08 11.48 21 122000 614 32390891
Selective eating disorder 27.06 11.48 33 121988 1703 32389802
Scaphocephaly 27.05 11.48 8 122013 19 32391486
Pulmonary fibrosis 27.02 11.48 15 122006 16959 32374546
Drug level above therapeutic 26.98 11.48 46 121975 3232 32388273
Device related infection 26.92 11.48 17 122004 17916 32373589
Nephrolithiasis 26.91 11.48 38 121983 27316 32364189
Rhinorrhoea 26.77 11.48 28 121993 22958 32368547
Phobia 26.75 11.48 13 122008 158 32391347
Blood potassium decreased 26.63 11.48 16 122005 17322 32374183
Drug hypersensitivity 26.47 11.48 164 121857 73236 32318269
Unresponsive to stimuli 26.47 11.48 186 121835 27423 32364082
Abdominal distension 26.40 11.48 101 121920 51194 32340311
Sluggishness 26.32 11.48 46 121975 3297 32388208
Infection 26.22 11.48 198 121823 84517 32306988
Gross motor delay 26.18 11.48 15 122006 260 32391245
Duodenal ulcer 26.11 11.48 4 122017 10451 32381054
Osteomyelitis 26.09 11.48 13 122008 15620 32375885
Head titubation 26.08 11.48 15 122006 262 32391243
Angular cheilitis 26.05 11.48 13 122008 168 32391337
Bicuspid aortic valve 26.04 11.48 14 122007 213 32391292
Heart rate decreased 25.81 11.48 34 121987 25166 32366339
Circadian rhythm sleep disorder 25.79 11.48 18 122003 446 32391059
Paradoxical drug reaction 25.65 11.48 42 121979 2854 32388651
Food interaction 25.57 11.48 24 121997 915 32390590
Cerebral palsy 25.43 11.48 11 122010 100 32391405
Diabetic hyperosmolar coma 25.42 11.48 17 122004 392 32391113
Staring 25.41 11.48 30 121991 1496 32390009
Condition aggravated 25.34 11.48 764 121257 154897 32236608
Pyrexia 25.29 11.48 964 121057 319004 32072501
Blood pressure fluctuation 25.22 11.48 23 121998 20112 32371393
Choroidal coloboma 25.11 11.48 6 122015 3 32391502
Retrognathia 25.10 11.48 14 122007 230 32391275
Blood bilirubin increased 25.07 11.48 69 121952 38715 32352790
Urinary tract infection 24.85 11.48 187 121834 79884 32311621
Peritonitis bacterial 24.76 11.48 8 122013 12488 32379017
Hypertension 24.66 11.48 347 121674 131403 32260102
Balance disorder 24.49 11.48 241 121780 39218 32352287
Microstomia 24.48 11.48 6 122015 4 32391501
Water intoxication 24.48 11.48 18 122003 485 32391020
Intentional product use issue 24.48 11.48 79 121942 42132 32349373
Acute hepatic failure 24.42 11.48 105 121916 12864 32378641
Metastases to liver 24.37 11.48 9 122012 12923 32378582
Aptyalism 24.34 11.48 15 122006 299 32391206
Renal tubular necrosis 24.19 11.48 15 122006 15963 32375542
Basilar artery occlusion 24.11 11.48 10 122011 81 32391424
Psychiatric decompensation 24.08 11.48 29 121992 1477 32390028
Peritonitis 24.04 11.48 29 121992 22301 32369204
Post-injection delirium sedation syndrome 24.01 11.48 17 122004 431 32391074
Neural tube defect 23.99 11.48 9 122012 54 32391451
Judgement impaired 23.99 11.48 20 122001 650 32390855
Gout 23.93 11.48 21 122000 18707 32372798
Faeces discoloured 23.89 11.48 13 122008 14864 32376641
Choking 23.86 11.48 57 121964 5109 32386396
Brain malformation 23.84 11.48 11 122010 118 32391387
Grandiosity 23.53 11.48 15 122006 318 32391187
Spine malformation 23.50 11.48 13 122008 210 32391295
Rash pruritic 23.41 11.48 35 121986 24576 32366929
Oropharyngeal discomfort 23.31 11.48 35 121986 2207 32389298
Drug intolerance 23.29 11.48 103 121918 50132 32341373
Oligoasthenozoospermia 23.28 11.48 7 122014 18 32391487
Hot flush 23.26 11.48 15 122006 15631 32375874
Congenital scoliosis 23.21 11.48 8 122013 36 32391469
Aminoaciduria 23.21 11.48 11 122010 126 32391379
Tonic clonic movements 23.20 11.48 25 121996 1127 32390378
Neoplasm malignant 23.15 11.48 22 121999 18863 32372642
Cerebral haemorrhage 23.08 11.48 61 121960 34686 32356819
Metabolic acidosis 23.07 11.48 244 121777 40455 32351050
Nephropathy toxic 23.05 11.48 8 122013 11938 32379567
Social (pragmatic) communication disorder 22.95 11.48 9 122012 62 32391443
Congenital neurological disorder 22.95 11.48 5 122016 0 32391505
Negativism 22.90 11.48 16 122005 397 32391108
Visuospatial deficit 22.82 11.48 9 122012 63 32391442
Metastases to bone 22.79 11.48 6 122015 10704 32380801
Pulmonary hypertension 22.72 11.48 26 121995 20468 32371037
Neuralgia 22.71 11.48 8 122013 11827 32379678
Frustration tolerance decreased 22.70 11.48 35 121986 2259 32389246
Deformity thorax 22.69 11.48 8 122013 39 32391466
Speech sound disorder 22.62 11.48 11 122010 134 32391371
Strabismus congenital 22.53 11.48 8 122013 40 32391465
Limb hypoplasia congenital 22.50 11.48 7 122014 21 32391484
Growth retardation 22.29 11.48 30 121991 1709 32389796
Decreased gait velocity 22.26 11.48 11 122010 139 32391366
Middle insomnia 22.23 11.48 64 121957 6420 32385085
Depressive symptom 22.23 11.48 31 121990 1827 32389678
Tic 22.21 11.48 33 121988 2061 32389444
Self-injurious ideation 22.19 11.48 29 121992 1605 32389900
Inflammation 22.19 11.48 36 121985 24457 32367048
Inguinal hernia 22.15 11.48 73 121948 7879 32383626
Type 2 diabetes mellitus 22.09 11.48 114 121907 15058 32376447
Salivary gland enlargement 22.02 11.48 7 122014 23 32391482
Amblyopia 22.01 11.48 9 122012 70 32391435
Localised infection 21.98 11.48 15 122006 15172 32376333
Mood swings 21.89 11.48 74 121947 8091 32383414
Pulmonary arterial hypertension 21.87 11.48 5 122016 9816 32381689
Hyperthermia 21.87 11.48 89 121932 10639 32380866
Energy increased 21.82 11.48 26 121995 1309 32390196
Patent ductus arteriosus 21.81 11.48 42 121979 3243 32388262
Throat irritation 21.73 11.48 5 122016 9773 32381732
Conductive deafness 21.72 11.48 11 122010 147 32391358
Diffuse large B-cell lymphoma 21.68 11.48 3 122018 8459 32383046
Overweight 21.68 11.48 29 121992 1642 32389863
Patient isolation 21.58 11.48 7 122014 25 32391480
Foetal growth restriction 21.56 11.48 47 121974 3965 32387540
Febrile bone marrow aplasia 21.52 11.48 3 122018 8412 32383093
Movement disorder 21.48 11.48 90 121931 10901 32380604
Muscular weakness 21.38 11.48 158 121863 67771 32323734
Epidermolysis bullosa 21.38 11.48 10 122011 111 32391394
Tachycardia 21.31 11.48 416 121605 78672 32312833
Candida infection 21.28 11.48 19 122002 16784 32374721
Pulmonary mass 21.13 11.48 9 122012 11851 32379654
Hallucination, visual 21.01 11.48 123 121898 17036 32374469
Flatulence 20.98 11.48 25 121996 19330 32372175
Clostridium difficile colitis 20.95 11.48 14 122007 14317 32377188
Ventricular tachycardia 20.94 11.48 40 121981 25516 32365989
Subacute endocarditis 20.92 11.48 8 122013 51 32391454
Miosis 20.85 11.48 76 121945 8628 32382877
Shock haemorrhagic 20.76 11.48 7 122014 10638 32380867
Incontinence 20.73 11.48 57 121964 5569 32385936
Cholestasis 20.71 11.48 44 121977 26989 32364516
Blood triglycerides increased 20.70 11.48 109 121912 14510 32376995
Head deformity 20.69 11.48 9 122012 83 32391422
Ammonia abnormal 20.69 11.48 9 122012 83 32391422
Blood osmolarity decreased 20.68 11.48 18 122003 621 32390884
Lacrimal gland enlargement 20.61 11.48 5 122016 3 32391502
Gastric volvulus 20.61 11.48 5 122016 3 32391502
Sensory integrative dysfunction 20.58 11.48 7 122014 30 32391475
Dry skin 20.55 11.48 39 121982 24939 32366566
Mydriasis 20.55 11.48 62 121959 6384 32385121
Delusional perception 20.54 11.48 11 122010 166 32391339
Mucosal ulceration 20.54 11.48 21 122000 890 32390615
Transplant rejection 20.53 11.48 6 122015 9993 32381512
Dissociation 20.50 11.48 24 121997 1186 32390319
Madarosis 20.50 11.48 12 122009 217 32391288
Bone marrow failure 20.48 11.48 53 121968 30351 32361154
Impaired healing 20.40 11.48 16 122005 15068 32376437
Depressed mood 20.39 11.48 128 121893 18172 32373333
Clostridium difficile infection 20.37 11.48 22 121999 17774 32373731
Type 1 diabetes mellitus 20.35 11.48 46 121975 3977 32387528
Tachyphrenia 20.34 11.48 24 121997 1196 32390309
Impaired reasoning 20.33 11.48 10 122011 125 32391380
Myoglobinuria 20.33 11.48 20 122001 809 32390696
COVID-19 pneumonia 20.32 11.48 4 122017 8716 32382789
Constipation 20.19 11.48 343 121678 126030 32265475
Ventricular septal defect 20.18 11.48 44 121977 3713 32387792
Carnitine deficiency 20.17 11.48 8 122013 57 32391448
Sarcopenia 20.16 11.48 14 122007 344 32391161
Hyponatraemia 20.09 11.48 392 121629 74121 32317384
Squamous cell carcinoma 20.06 11.48 8 122013 10960 32380545
Anomaly of external ear congenital 20.06 11.48 10 122011 129 32391376
Gastric disorder 19.92 11.48 9 122012 11447 32380058
Cardiac disorder 19.92 11.48 85 121936 41781 32349724
Adrenal insufficiency 19.90 11.48 10 122011 11958 32379547
Gingival hypertrophy 19.81 11.48 28 121993 1671 32389834
Haemangioma 19.72 11.48 29 121992 1795 32389710
Developmental regression 19.71 11.48 7 122014 35 32391470
Ehlers-Danlos syndrome 19.71 11.48 7 122014 35 32391470
Wrong product administered 19.64 11.48 52 121969 4968 32386537
Ageusia 19.60 11.48 6 122015 9696 32381809
Poverty of speech 19.52 11.48 12 122009 238 32391267
Trismus 19.51 11.48 35 121986 2560 32388945
Kyphosis congenital 19.50 11.48 5 122016 5 32391500
Incoherent 19.49 11.48 48 121973 4386 32387119
Hyperexplexia 19.39 11.48 7 122014 37 32391468
Pneumonia bacterial 19.30 11.48 8 122013 10708 32380797
IVth nerve disorder 19.28 11.48 6 122015 18 32391487
Limb discomfort 19.25 11.48 7 122014 10147 32381358
Hostility 19.19 11.48 20 122001 867 32390638
Feeling hot 19.19 11.48 21 122000 16865 32374640
Micrognathia 19.17 11.48 13 122008 307 32391198
Immune reconstitution inflammatory syndrome 19.15 11.48 6 122015 9553 32381952
Hyperhomocysteinaemia 19.13 11.48 11 122010 192 32391313
Otitis media 19.09 11.48 36 121985 2737 32388768
Cardiogenic shock 19.06 11.48 30 121991 20632 32370873
Myelosuppression 19.05 11.48 10 122011 11666 32379839
Iris coloboma 19.04 11.48 6 122015 19 32391486
Pulmonary oedema 19.04 11.48 99 121922 46168 32345337
Aspiration 18.97 11.48 88 121933 11135 32380370
Rhabdomyolysis 18.86 11.48 356 121665 66909 32324596
Failure to suspend medication 18.84 11.48 13 122008 316 32391189
Skin cancer 18.75 11.48 5 122016 8845 32382660
Tonsillitis 18.73 11.48 31 121990 2125 32389380
Phimosis 18.71 11.48 18 122003 708 32390797
Blood lactic acid increased 18.71 11.48 59 121962 6222 32385283
Cerebral infarction 18.70 11.48 48 121973 27566 32363939
Gastric ulcer 18.70 11.48 19 122002 15790 32375715
Lower gastrointestinal haemorrhage 18.64 11.48 5 122016 8812 32382693
Aura 18.63 11.48 13 122008 322 32391183
Intermittent explosive disorder 18.59 11.48 5 122016 7 32391498
Polydipsia 18.59 11.48 43 121978 3774 32387731
Pleural effusion 18.58 11.48 198 121823 78794 32312711
Coma blister 18.56 11.48 8 122013 72 32391433
Verbal abuse 18.50 11.48 11 122010 205 32391300
Maternal drugs affecting foetus 18.49 11.48 46 121975 4231 32387274
Agranulocytosis 18.47 11.48 151 121870 23326 32368179
Poor sucking reflex 18.45 11.48 13 122008 327 32391178
Jaundice 18.39 11.48 66 121955 34092 32357413
Refraction disorder 18.37 11.48 6 122015 22 32391483
Ear, nose and throat examination abnormal 18.36 11.48 4 122017 0 32391505
Retracted nipple 18.36 11.48 4 122017 0 32391505
Laryngeal web 18.36 11.48 4 122017 0 32391505
Blood pressure systolic increased 18.30 11.48 23 121998 17373 32374132
Squamous cell carcinoma of skin 18.25 11.48 7 122014 9819 32381686
Resting tremor 18.22 11.48 17 122004 643 32390862
Graft versus host disease 18.01 11.48 9 122012 10797 32380708
Craniofacial deformity 18.01 11.48 8 122013 78 32391427
Venoocclusive liver disease 17.98 11.48 3 122018 7362 32384143
School refusal 17.97 11.48 6 122015 24 32391481
Compensatory sweating 17.97 11.48 6 122015 24 32391481
Febrile convulsion 17.91 11.48 16 122005 572 32390933
Necrotising colitis 17.90 11.48 21 122000 1040 32390465
Lennox-Gastaut syndrome 17.87 11.48 7 122014 48 32391457
Pasteurella infection 17.83 11.48 5 122016 9 32391496
Cholelithiasis 17.78 11.48 32 121989 20880 32370625
Simple partial seizures 17.78 11.48 12 122009 281 32391224
Intestinal ischaemia 17.75 11.48 64 121957 7227 32384278
Dementia with Lewy bodies 17.66 11.48 17 122004 669 32390836
Hepatic function abnormal 17.66 11.48 251 121770 44589 32346916
Supernumerary nipple 17.63 11.48 7 122014 50 32391455
Conjunctival hyperaemia 17.60 11.48 32 121989 2366 32389139
Hypoxia 17.51 11.48 119 121902 52013 32339492
Thought blocking 17.47 11.48 9 122012 125 32391380
Large intestine polyp 17.45 11.48 3 122018 7203 32384302
Hepatitis C virus test positive 17.38 11.48 14 122007 433 32391072
Hypokinesia 17.35 11.48 70 121951 8335 32383170
Oral candidiasis 17.24 11.48 12 122009 12015 32379490
Blood glucose increased 17.23 11.48 159 121862 65082 32326423
MELAS syndrome 17.23 11.48 6 122015 28 32391477
Diverticulitis 17.20 11.48 28 121993 19000 32372505
Cataract 17.19 11.48 41 121980 24142 32367363
Conversion disorder 17.19 11.48 13 122008 366 32391139
Epileptic aura 17.17 11.48 5 122016 11 32391494
Contusion 17.15 11.48 66 121955 33402 32358103
Frequent bowel movements 17.12 11.48 7 122014 9445 32382060
Adenoidectomy 17.08 11.48 8 122013 89 32391416
Presyncope 17.05 11.48 24 121997 17277 32374228
Brachydactyly 16.98 11.48 10 122011 183 32391322
Social problem 16.96 11.48 19 122002 895 32390610
Withdrawal syndrome 16.90 11.48 90 121931 12032 32379473
Mixed delusion 16.87 11.48 5 122016 12 32391493
Suspiciousness 16.83 11.48 13 122008 378 32391127
Automatism 16.78 11.48 8 122013 93 32391412
Neutrophil Pelger-Huet anomaly present 16.70 11.48 11 122010 247 32391258
Tendonitis 16.60 11.48 6 122015 8729 32382776
Lymphoma 16.54 11.48 10 122011 10790 32380715
Neutropenic sepsis 16.51 11.48 14 122007 12685 32378820
Dermatitis 16.50 11.48 6 122015 8698 32382807
Body dysmorphic disorder 16.48 11.48 8 122013 97 32391408
Dyspepsia 16.42 11.48 66 121955 32989 32358516
Product administered to patient of inappropriate age 16.38 11.48 34 121987 2772 32388733
Pain in jaw 16.32 11.48 14 122007 12612 32378893
Schizoaffective disorder bipolar type 16.24 11.48 7 122014 63 32391442
Brachycephaly 16.15 11.48 7 122014 64 32391441
Hyperglycinaemia 16.13 11.48 4 122017 3 32391502
Sperm concentration decreased 16.13 11.48 9 122012 148 32391357
Neurological decompensation 16.12 11.48 33 121988 2665 32388840
Skin exfoliation 16.08 11.48 45 121976 25112 32366393
Screaming 16.04 11.48 23 121998 1391 32390114
Meningomyelocele 15.98 11.48 10 122011 205 32391300
Toxic epidermal necrolysis 15.96 11.48 132 121889 20461 32371044
Injection site swelling 15.95 11.48 8 122013 9576 32381929
Hepatic cirrhosis 15.90 11.48 24 121997 16785 32374720
Opsoclonus myoclonus 15.87 11.48 7 122014 67 32391438
Enterocolitis 15.83 11.48 4 122017 7336 32384169
Erectile dysfunction 15.82 11.48 128 121893 19711 32371794
Hyporeflexia 15.80 11.48 28 121993 2029 32389476
Irregular sleep phase 15.78 11.48 7 122014 68 32391437
Wrist deformity 15.77 11.48 12 122009 341 32391164
Coronary artery occlusion 15.76 11.48 12 122009 11473 32380032
Retinogram abnormal 15.72 11.48 8 122013 108 32391397
Haemorrhoids 15.72 11.48 15 122006 12838 32378667
Muscle twitching 15.68 11.48 70 121951 8714 32382791
Oral mucosa erosion 15.64 11.48 18 122003 873 32390632
Abnormal labour affecting foetus 15.60 11.48 5 122016 17 32391488
Epileptic psychosis 15.60 11.48 5 122016 17 32391488
Nephrogenic diabetes insipidus 15.52 11.48 22 121999 1316 32390189
Drug level fluctuating 15.52 11.48 14 122007 507 32390998
Cardiac failure chronic 15.51 11.48 4 122017 7236 32384269
Use of accessory respiratory muscles 15.50 11.48 12 122009 350 32391155
Apparent life threatening event 15.48 11.48 10 122011 217 32391288
Excessive masturbation 15.41 11.48 8 122013 113 32391392
Reproductive tract hypoplasia, male 15.38 11.48 5 122016 18 32391487
Colon cancer 15.36 11.48 7 122014 8859 32382646
Syndactyly 15.36 11.48 17 122004 790 32390715
Throat tightness 15.33 11.48 5 122016 7761 32383744
Acute pulmonary oedema 15.26 11.48 5 122016 7736 32383769
Electrocardiogram QT prolonged 15.26 11.48 221 121800 39420 32352085
Peripheral sensory neuropathy 15.16 11.48 3 122018 6511 32384994
Wheezing 15.11 11.48 79 121942 36795 32354710
Postural tremor 15.07 11.48 12 122009 365 32391140
Hepatocellular carcinoma 15.05 11.48 10 122011 10260 32381245
Poor quality sleep 14.91 11.48 65 121956 8009 32383496
Skin ulcer 14.91 11.48 35 121986 20724 32370781
Rebound psychosis 14.89 11.48 9 122012 173 32391332
Suspected suicide attempt 14.87 11.48 8 122013 122 32391383
Aphasia 14.82 11.48 131 121890 20697 32370808
Cardiac failure acute 14.82 11.48 10 122011 10174 32381331
Injection site erythema 14.80 11.48 20 122001 14648 32376857
Muscle contracture 14.80 11.48 21 122000 1258 32390247
Injection site reaction 14.75 11.48 13 122008 11556 32379949
Psychomotor disadaptation syndrome 14.71 11.48 4 122017 6 32391499
Contraindicated product administered 14.65 11.48 31 121990 19045 32372460
Gingival atrophy 14.64 11.48 6 122015 47 32391458
C-reactive protein abnormal 14.64 11.48 3 122018 6353 32385152
Hepatitis B 14.59 11.48 3 122018 6338 32385167
Abnormal palmar/plantar creases 14.57 11.48 10 122011 241 32391264
Camptocormia 14.53 11.48 9 122012 181 32391324
Clonic convulsion 14.51 11.48 15 122006 644 32390861
Wrong technique in product usage process 14.43 11.48 75 121946 34984 32356521
Partial seizures with secondary generalisation 14.42 11.48 10 122011 245 32391260
Disseminated intravascular coagulation 14.41 11.48 42 121979 23134 32368371
Myocardial ischaemia 14.37 11.48 28 121993 17731 32373774
Chromaturia 14.35 11.48 20 122001 14458 32377047
Hypothyroidism 14.35 11.48 111 121910 16864 32374641
Heterophoria 14.32 11.48 6 122015 50 32391455
Wound 14.28 11.48 17 122004 13150 32378355
Embolism 14.24 11.48 5 122016 7409 32384096
Diarrhoea haemorrhagic 14.24 11.48 3 122018 6232 32385273
Fungal infection 14.22 11.48 22 121999 15233 32376272
Drug resistance 14.12 11.48 140 121881 22825 32368680
Agitation neonatal 14.11 11.48 19 122002 1083 32390422
Hypomagnesaemia 14.08 11.48 31 121990 18774 32372731
Kyphosis 14.03 11.48 19 122002 1089 32390416
Pulmonary valve incompetence 14.02 11.48 16 122005 769 32390736
Anamnestic reaction 14.02 11.48 6 122015 53 32391452
Device issue 14.01 11.48 8 122013 8904 32382601
Ischaemic stroke 13.98 11.48 28 121993 17548 32373957
Hallucination 13.90 11.48 276 121745 52343 32339162
Hyperthyroidism 13.88 11.48 9 122012 9353 32382152
Cardiovascular disorder 13.83 11.48 12 122009 10750 32380755
Cerebral cyst 13.81 11.48 10 122011 263 32391242
Enteritis 13.77 11.48 5 122016 7256 32384249
Dacryoadenitis acquired 13.77 11.48 3 122018 0 32391505
Acquired epileptic aphasia 13.77 11.48 3 122018 0 32391505
Hypocarnitinaemia 13.77 11.48 3 122018 0 32391505
Mentally late developer 13.77 11.48 3 122018 0 32391505
Dentofacial anomaly 13.77 11.48 3 122018 0 32391505
Blindness congenital 13.77 11.48 3 122018 0 32391505
Renal fusion anomaly 13.77 11.48 3 122018 0 32391505
Reduced facial expression 13.76 11.48 17 122004 889 32390616
Hyperreflexia 13.72 11.48 33 121988 2971 32388534
Pancreatic carcinoma 13.72 11.48 7 122014 8299 32383206
Congenital nipple anomaly 13.68 11.48 4 122017 9 32391496
Elbow deformity 13.68 11.48 4 122017 9 32391496
Osteonecrosis 13.63 11.48 26 121995 16596 32374909
Sinus disorder 13.62 11.48 4 122017 6640 32384865
Septum pellucidum agenesis 13.62 11.48 5 122016 28 32391477
CSF white blood cell count positive 13.62 11.48 5 122016 28 32391477
Frontotemporal dementia 13.58 11.48 10 122011 270 32391235
Dysphagia 13.52 11.48 314 121707 61162 32330343
Pancreatitis haemorrhagic 13.47 11.48 11 122010 347 32391158
Niemann-Pick disease 13.46 11.48 6 122015 59 32391446
Heart rate irregular 13.41 11.48 20 122001 14058 32377447
Spinal fracture 13.33 11.48 5 122016 7111 32384394
Mental disability 13.33 11.48 5 122016 30 32391475
Posterior reversible encephalopathy syndrome 13.29 11.48 71 121950 9505 32382000
Adverse drug reaction 13.25 11.48 51 121970 25810 32365695
Hip fracture 13.24 11.48 15 122006 11860 32379645
Mastication disorder 13.20 11.48 20 122001 1271 32390234
Bronchospasm 13.15 11.48 13 122008 10942 32380563
Laryngitis 13.12 11.48 27 121994 2188 32389317
Hand-eye coordination impaired 13.12 11.48 6 122015 63 32391442
Feeding disorder 13.11 11.48 54 121967 6491 32385014
Haemorrhagic stroke 13.10 11.48 4 122017 6474 32385031
Ankyloglossia congenital 13.06 11.48 10 122011 287 32391218
Back disorder 13.05 11.48 4 122017 6459 32385046
Maternal exposure during pregnancy 13.04 11.48 41 121980 4316 32387189
Dependent personality disorder 13.03 11.48 6 122015 64 32391441
Congenital genital malformation 13.03 11.48 6 122015 64 32391441
Myopathy 13.00 11.48 14 122007 11327 32380178
Arachnoid cyst 13.00 11.48 9 122012 220 32391285
Heat stroke 12.99 11.48 17 122004 942 32390563
Ischaemic cardiomyopathy 12.96 11.48 4 122017 6430 32385075
Respiratory fatigue 12.87 11.48 6 122015 66 32391439
Monorchidism 12.86 11.48 4 122017 12 32391493
Congenital cerebral cyst 12.86 11.48 4 122017 12 32391493
Locomotive syndrome 12.86 11.48 4 122017 12 32391493
Delayed fontanelle closure 12.80 11.48 5 122016 34 32391471
Malocclusion 12.79 11.48 6 122015 67 32391438
Vasoplegia syndrome 12.76 11.48 21 122000 1433 32390072
Small intestinal obstruction 12.73 11.48 21 122000 14175 32377330
Terminal insomnia 12.69 11.48 12 122009 462 32391043
Pulmonary thrombosis 12.69 11.48 5 122016 6899 32384606
Pulmonary haemorrhage 12.65 11.48 11 122010 9846 32381659
Joint hyperextension 12.64 11.48 6 122015 69 32391436
Anticoagulation drug level decreased 12.64 11.48 6 122015 69 32391436
Blunted affect 12.62 11.48 10 122011 302 32391203
Cardiac murmur 12.61 11.48 57 121964 7134 32384371
Metastases to lung 12.60 11.48 8 122013 8409 32383096
Feminisation acquired 12.56 11.48 5 122016 36 32391469
Therapeutic response changed 12.55 11.48 11 122010 383 32391122
Heparin-induced thrombocytopenia 12.55 11.48 3 122018 5711 32385794
Hypovolaemia 12.54 11.48 9 122012 8868 32382637
Intestinal perforation 12.53 11.48 9 122012 8866 32382639
Blood alkaline phosphatase increased 12.53 11.48 70 121951 32062 32359443
Coronary artery stenosis 12.49 11.48 11 122010 9782 32381723
Gender dysphoria 12.44 11.48 5 122016 37 32391468
Cholangitis 12.44 11.48 8 122013 8350 32383155
Polyserositis 12.41 11.48 8 122013 173 32391332
Glomerular filtration rate decreased 12.40 11.48 18 122003 12793 32378712
Hypotony maculopathy 12.39 11.48 4 122017 14 32391491
Nocturia 12.39 11.48 10 122011 9284 32382221
Pulmonary eosinophilia 12.35 11.48 9 122012 239 32391266
Intentional product misuse 12.33 11.48 197 121824 35854 32355651
Haematoma 12.31 11.48 52 121969 25632 32365873
Gallbladder disorder 12.28 11.48 4 122017 6213 32385292
Accidental death 12.27 11.48 26 121995 2151 32389354
Slow response to stimuli 12.27 11.48 15 122006 776 32390729
Anxiety disorder 12.22 11.48 22 121999 1614 32389891
Urosepsis 12.22 11.48 16 122005 11874 32379631
Pica 12.18 11.48 4 122017 15 32391490
Brain stem auditory evoked response abnormal 12.18 11.48 4 122017 15 32391490
Feeling of despair 12.17 11.48 17 122004 1003 32390502
Eating disorder 12.14 11.48 59 121962 7609 32383896
Neutropenia 12.12 11.48 651 121370 141524 32249981
Cytotoxic oedema 12.09 11.48 8 122013 181 32391324
Snoring 12.06 11.48 32 121989 3061 32388444
Haemorrhage intracranial 12.05 11.48 26 121995 15861 32375644
Hypercalcaemia 12.05 11.48 21 122000 13873 32377632
Sudden death 12.02 11.48 103 121918 16129 32375376
Cytopenia 12.01 11.48 12 122009 10052 32381453
Polydipsia psychogenic 11.99 11.48 7 122014 126 32391379
Mass 11.95 11.48 7 122014 7685 32383820
Infertility male 11.94 11.48 8 122013 185 32391320
Diabetic coma 11.92 11.48 16 122005 909 32390596
Injection site pruritus 11.89 11.48 4 122017 6086 32385419
Gastritis 11.87 11.48 42 121979 21785 32369720
Congenital inguinal hernia 11.84 11.48 7 122014 129 32391376
Myoglobin urine present 11.83 11.48 8 122013 188 32391317
Urine output decreased 11.83 11.48 13 122008 10421 32381084
Progressive multifocal leukoencephalopathy 11.80 11.48 11 122010 9520 32381985
Kidney malformation 11.79 11.48 8 122013 189 32391316
Poisoning 11.78 11.48 77 121944 11081 32380424
Abulia 11.73 11.48 12 122009 509 32390996
Illusion 11.72 11.48 15 122006 813 32390692
Congenital cardiovascular anomaly 11.72 11.48 8 122013 191 32391314
Mitochondrial DNA mutation 11.70 11.48 3 122018 3 32391502
Near drowning 11.70 11.48 3 122018 3 32391502
Kluver-Bucy syndrome 11.70 11.48 3 122018 3 32391502
Nasopharyngeal reflux 11.70 11.48 3 122018 3 32391502
Post-anoxic myoclonus 11.70 11.48 3 122018 3 32391502
Drowning 11.68 11.48 11 122010 421 32391084
Therapy interrupted 11.66 11.48 8 122013 8070 32383435
Cyanosis central 11.65 11.48 7 122014 133 32391372
Skin lesion 11.65 11.48 38 121983 20203 32371302
Vanishing bile duct syndrome 11.64 11.48 14 122007 712 32390793
Infertility 11.57 11.48 8 122013 195 32391310

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35477 antimanics
CHEBI has role CHEBI:35623 antiepileptic
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:176497 anti-aging drugs
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:35471 psychopharmaceuticals
CHEBI has role CHEBI:50905 teratogen
CHEBI has role CHEBI:61115 HDAC inhibitor
CHEBI has role CHEBI:63726 neuroprotective agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase-related protein 1 Enzyme IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL433 ChEMBL_ID
D014635 MESH_DESCRIPTOR_UI
3121 PUBCHEM_CID
3300 INN_ID
7009 IUPHAR_LIGAND_ID
5132 INN_ID
614OI1Z5WI UNII
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
5641004 SNOMEDCT_US
CHEMBL2315212 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 31 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 29 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0527-5250 SOLUTION 250 mg ORAL ANDA 30 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0591-4012 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 29 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-1325 CAPSULE 250 mg ORAL ANDA 24 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0615-7840 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 27 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8205 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 23 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8237 CAPSULE 125 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8326 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8327 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8328 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 31 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8329 TABLET, EXTENDED RELEASE 250 mg ORAL ANDA 28 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8330 TABLET, EXTENDED RELEASE 500 mg ORAL ANDA 28 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8376 TABLET, EXTENDED RELEASE 250 mg ORAL ANDA 28 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8377 TABLET, EXTENDED RELEASE 500 mg ORAL ANDA 28 sections
valproic acid HUMAN PRESCRIPTION DRUG LABEL 1 0832-0310 CAPSULE 250 mg ORAL ANDA 30 sections