tyrosine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2786 60-18-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tyrosine
  • L-Tyrosine
  • (S)-Tyrosine
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
  • Molecular weight: 181.19
  • Formula: C9H11NO3
  • CLOGP: -2.22
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 83.55
  • ALOGS: -1.37
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal growth restriction 100.00 64.73 15 98 1125 2356847

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.27 acidic
pKa2 10.4 acidic
pKa3 9.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018678 VUID
N0000146989 NUI
C0041485 UMLSCUI
D00022 KEGG_DRUG
42HK56048U UNII
6174 INN_ID
418246001 SNOMEDCT_US
27378009 SNOMEDCT_US
4018678 VANDF
NOCODE MMSL
10962 RXNORM
003449 NDDF
187423 MMSL
15487 MMSL
d07831 MMSL
6057 PUBCHEM_CID
CHEBI:18186 CHEBI
CHEMBL925 ChEMBL_ID
DB00135 DRUGBANK_ID
D014443 MESH_DESCRIPTOR_UI
4791 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 39 mg INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 39 mg INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 39 mg INTRAVENOUS ANDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.04 g INTRAVENOUS NDA 12 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.04 g INTRAVENOUS NDA 12 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 15 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 39 mg INTRAVENOUS ANDA 11 sections
Travasol HUMAN PRESCRIPTION DRUG LABEL 15 0338-0644 INJECTION 40 mg INTRAVENOUS NDA 15 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1083 INJECTION 11 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1089 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1091 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1093 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1095 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1099 INJECTION 20 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1101 INJECTION 20 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 15 0338-1103 INJECTION 20 mg INTRAVENOUS NDA 14 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1107 INJECTION 11 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1109 INJECTION 11 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1113 INJECTION 17 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1115 INJECTION 17 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1119 INJECTION 17 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1123 INJECTION 20 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1125 INJECTION 20 mg INTRAVENOUS NDA 16 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1127 INJECTION 20 mg INTRAVENOUS NDA 16 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.24 g INTRAVENOUS ANDA 12 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 0.14 g INTRAVENOUS ANDA 12 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1132 INJECTION 11 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1133 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1134 INJECTION 17 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 15 0338-1135 INJECTION 17 mg INTRAVENOUS NDA 14 sections