tropicamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| atropine derivatives | 2774 | 1508-75-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 23, 1960 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01FA06 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics |
| ATC | S01FA56 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics |
| FDA EPC | N0000175574 | Anticholinergic |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018727 | Muscarinic Antagonists |
| MeSH PA | D009184 | Mydriatics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dilated pupil | indication | 37125009 | |
| Cycloplegia | indication | 68158006 | DOID:10033 |
| Perioperative Mydriasis | indication | ||
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Shallow anterior chamber of eye | contraindication | 246986004 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Primary Closed Angle Glaucoma | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | Ki | 7.52 | DRUG MATRIX | CHEMBL | |||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.17 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.43 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 8.46 | PDSP | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.19 | DRUG MATRIX | |||||
| Cytochrome P450 2C9 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
| Cytochrome P450 2C19 | Enzyme | IC50 | 6 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4018592 | VUID |
| N0000146908 | NUI |
| C0041190 | UMLSCUI |
| D00397 | KEGG_DRUG |
| 9190005 | SNOMEDCT_US |
| 3084 | MMSL |
| 10869 | RXNORM |
| 387526001 | SNOMEDCT_US |
| 5645 | MMSL |
| 4018592 | VANDF |
| 001726 | NDDF |
| CHEBI:9757 | CHEBI |
| DB00809 | DRUGBANK_ID |
| CHEMBL1200604 | ChEMBL_ID |
| N0A3Z5XTC6 | UNII |
| 1059 | INN_ID |
| 5593 | PUBCHEM_CID |
| D014331 | MESH_DESCRIPTOR_UI |
| 7319 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Mydriacyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0355 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7192 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Mydriacyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0998-0355 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-101 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 11 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-102 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Paremyd | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-704 | SOLUTION | 2.50 mg | OPHTHALMIC | NDA | 12 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-585 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 10 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-590 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 10 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-354 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 11 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-355 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-4004 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 10 sections |
| Tropicamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70069-121 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 10 sections |
| Mydriatic-4 | HUMAN PRESCRIPTION DRUG LABEL | 4 | 71384-632 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | unapproved drug other | 1 sections |