tropicamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 2774 1508-75-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tropicamide
  • bistropamide
  • epitromina
  • mydriacyl
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
  • Molecular weight: 284.36
  • Formula: C17H20N2O2
  • CLOGP: 1.18
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 53.43
  • ALOGS: -2.88
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 23, 1960 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 207.15 48.01 36 1341 1529 50602218
Macular oedema 141.71 48.01 30 1347 3624 50600123
Vision blurred 120.19 48.01 53 1324 78594 50525153
Visual acuity reduced 119.89 48.01 37 1340 20102 50583645
Cataract nuclear 108.16 48.01 19 1358 854 50602893
Vitreous floaters 104.19 48.01 25 1352 5289 50598458
Corneal oedema 99.38 48.01 19 1358 1368 50602379
Retinal haemorrhage 97.32 48.01 23 1354 4558 50599189
Cystoid macular oedema 86.87 48.01 17 1360 1382 50602365
Visual impairment 72.99 48.01 36 1341 68239 50535508
Therapeutic product effect prolonged 60.73 48.01 10 1367 303 50603444
Hypopyon 59.51 48.01 11 1366 658 50603089
Eye pain 59.39 48.01 24 1353 28425 50575322
Metamorphopsia 55.42 48.01 11 1366 960 50602787
Choroidal neovascularisation 54.55 48.01 9 1368 276 50603471
Vitreous detachment 54.16 48.01 12 1365 1782 50601965
Cataract 53.66 48.01 26 1351 47274 50556473
Detachment of retinal pigment epithelium 52.52 48.01 9 1368 348 50603399
Eye irritation 52.03 48.01 19 1358 17121 50586626
Retinal disorder 50.82 48.01 11 1366 1466 50602281

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 183.38 45.13 32 1076 1004 29572415
Vitreous floaters 109.53 45.13 25 1083 3096 29570323
Visual acuity reduced 102.71 45.13 33 1075 14843 29558576
Vision blurred 80.33 45.13 36 1072 40140 29533279
Blindness 56.49 45.13 20 1088 12003 29561416
Retinal haemorrhage 52.58 45.13 15 1093 4489 29568930
Floppy iris syndrome 51.01 45.13 9 1099 298 29573121
Corneal oedema 50.14 45.13 11 1097 1131 29572288
Cataract nuclear 46.92 45.13 9 1099 475 29572944
Macular oedema 46.60 45.13 12 1096 2446 29570973

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 381.23 36.94 66 1960 2373 64494333
Visual acuity reduced 171.58 36.94 54 1972 27087 64469619
Corneal oedema 138.63 36.94 28 1998 2315 64494391
Vision blurred 129.84 36.94 61 1965 90255 64406451
Vitreous floaters 105.80 36.94 27 1999 6346 64490360
Macular oedema 102.73 36.94 25 2001 4842 64491864
Blindness 87.80 36.94 31 1995 21988 64474718
Retinal haemorrhage 73.92 36.94 21 2005 7377 64489329
Cataract nuclear 71.94 36.94 14 2012 953 64495753
Eye pain 70.03 36.94 29 1997 31596 64465110
Visual impairment 67.98 36.94 37 1989 74040 64422666
Endophthalmitis 66.33 36.94 18 2008 5347 64491359
Vitritis 65.51 36.94 14 2012 1519 64495187
Hypopyon 65.03 36.94 13 2013 1016 64495690
Retinal disorder 63.30 36.94 14 2012 1782 64494924
Cataract 53.75 36.94 28 1998 51234 64445472
Cystoid macular oedema 52.56 36.94 12 2014 1762 64494944
Eye irritation 50.77 36.94 19 2007 15837 64480869
Intraocular pressure increased 50.19 36.94 16 2010 8286 64488420
Choroidal neovascularisation 49.59 36.94 9 2017 419 64496287
Angle closure glaucoma 47.74 36.94 12 2014 2645 64494061
Macular fibrosis 44.99 36.94 9 2017 705 64496001
Eye inflammation 44.98 36.94 13 2013 4844 64491862
Anterior chamber cell 43.71 36.94 9 2017 815 64495891
Ophthalmological examination abnormal 41.48 36.94 6 2020 64 64496642
Vitreous detachment 41.07 36.94 10 2016 1934 64494772
Ocular hyperaemia 41.01 36.94 18 2008 22546 64474160
Metamorphopsia 40.86 36.94 9 2017 1123 64495583
Detachment of retinal pigment epithelium 39.47 36.94 8 2018 670 64496036
Retinal scar 37.35 36.94 7 2019 389 64496317

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01FA06 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA56 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
FDA MoA N0000175370 Cholinergic Antagonists
FDA EPC N0000175574 Anticholinergic
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Shallow anterior chamber of eye contraindication 246986004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Primary Closed Angle Glaucoma contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 7.52 DRUG MATRIX CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.43 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.17 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 7.19 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 6 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 8.46 PDSP

External reference:

IDSource
4018592 VUID
N0000146908 NUI
D00397 KEGG_DRUG
4018592 VANDF
C0041190 UMLSCUI
CHEBI:9757 CHEBI
CHEMBL1200604 ChEMBL_ID
DB00809 DRUGBANK_ID
D014331 MESH_DESCRIPTOR_UI
5593 PUBCHEM_CID
7319 IUPHAR_LIGAND_ID
1059 INN_ID
N0A3Z5XTC6 UNII
10869 RXNORM
1997 MMSL
3084 MMSL
5645 MMSL
001726 NDDF
387526001 SNOMEDCT_US
9190005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mydriacyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 0404-7192 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 18 sections
Mydriacyl HUMAN PRESCRIPTION DRUG LABEL 1 0998-0355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-101 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 18 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-101 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 18 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-102 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 18 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-102 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 18 sections
Paremyd HUMAN PRESCRIPTION DRUG LABEL 2 17478-704 SOLUTION 2.50 mg OPHTHALMIC NDA 21 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 24208-585 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 17 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 24208-590 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 17 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 61314-354 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 19 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 61314-354 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 19 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 61314-355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 70069-121 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 16 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 70518-2759 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 19 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 70518-2759 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 19 sections
Mydriatic-4 HUMAN PRESCRIPTION DRUG LABEL 4 71384-632 SOLUTION/ DROPS 10 mg OPHTHALMIC unapproved drug other 2 sections