Stem definition | Drug id | CAS RN |
---|---|---|
antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues | 2755 | 738-70-5 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1.37 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 70 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 15.75 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 98 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.50 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 30, 1973 | FDA | MUTUAL PHARM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Soft tissue disorder | 178.45 | 10.84 | 81 | 49266 | 4341 | 63435334 |
Acute kidney injury | 160.23 | 10.84 | 509 | 48838 | 262906 | 63176769 |
Drug ineffective | 122.82 | 10.84 | 411 | 48936 | 1044354 | 62395321 |
Liver function test abnormal | 121.79 | 10.84 | 168 | 49179 | 48013 | 63391662 |
Swelling face | 119.80 | 10.84 | 193 | 49154 | 63282 | 63376393 |
Pre-engraftment immune reaction | 102.78 | 10.84 | 26 | 49321 | 212 | 63439463 |
Leukopenia | 98.42 | 10.84 | 198 | 49149 | 77092 | 63362583 |
Pneumonia viral | 96.75 | 10.84 | 66 | 49281 | 7856 | 63431819 |
Hyperkalaemia | 94.45 | 10.84 | 159 | 49188 | 54044 | 63385631 |
Pancytopenia | 93.46 | 10.84 | 222 | 49125 | 96711 | 63342964 |
Pyrexia | 92.15 | 10.84 | 653 | 48694 | 469825 | 62969850 |
Product dose omission issue | 86.37 | 10.84 | 37 | 49310 | 234276 | 63205399 |
Stevens-Johnson syndrome | 83.49 | 10.84 | 100 | 49247 | 24850 | 63414825 |
Hyponatraemia | 77.94 | 10.84 | 227 | 49120 | 111673 | 63328002 |
Encephalitis viral | 77.15 | 10.84 | 34 | 49313 | 1698 | 63437977 |
Completed suicide | 68.00 | 10.84 | 15 | 49332 | 145658 | 63294017 |
Rash maculo-papular | 65.72 | 10.84 | 101 | 49246 | 31795 | 63407880 |
Cytomegalovirus infection | 63.67 | 10.84 | 80 | 49267 | 20872 | 63418803 |
Lip swelling | 63.49 | 10.84 | 98 | 49249 | 30965 | 63408710 |
Injection site pain | 63.42 | 10.84 | 12 | 49335 | 129788 | 63309887 |
Abdominal discomfort | 62.96 | 10.84 | 95 | 49252 | 320790 | 63118885 |
Fatigue | 62.84 | 10.84 | 419 | 48928 | 887609 | 62552066 |
Human herpesvirus 6 infection | 62.62 | 10.84 | 35 | 49312 | 2922 | 63436753 |
Alopecia | 61.45 | 10.84 | 105 | 49242 | 337431 | 63102244 |
Allergy to chemicals | 59.01 | 10.84 | 34 | 49313 | 3008 | 63436667 |
Tenosynovitis stenosans | 58.42 | 10.84 | 35 | 49312 | 3329 | 63436346 |
Ejection fraction decreased | 58.11 | 10.84 | 79 | 49268 | 22253 | 63417422 |
Product use issue | 57.52 | 10.84 | 52 | 49295 | 220468 | 63219207 |
Systemic lupus erythematosus | 56.02 | 10.84 | 48 | 49299 | 208870 | 63230805 |
Synovial fluid analysis | 54.82 | 10.84 | 30 | 49317 | 2403 | 63437272 |
International normalised ratio increased | 54.44 | 10.84 | 115 | 49232 | 46310 | 63393365 |
Off label use | 53.98 | 10.84 | 306 | 49041 | 674156 | 62765519 |
Scleritis | 51.97 | 10.84 | 36 | 49311 | 4392 | 63435283 |
Toxic epidermal necrolysis | 50.48 | 10.84 | 79 | 49268 | 25255 | 63414420 |
Kidney transplant rejection | 48.43 | 10.84 | 34 | 49313 | 4237 | 63435438 |
Maternal exposure during pregnancy | 48.32 | 10.84 | 60 | 49287 | 220002 | 63219673 |
Tenderness | 47.22 | 10.84 | 72 | 49275 | 22506 | 63417169 |
Photophobia | 46.82 | 10.84 | 63 | 49284 | 17572 | 63422103 |
Pleuritic pain | 46.25 | 10.84 | 43 | 49304 | 7986 | 63431689 |
Conjunctivitis | 45.89 | 10.84 | 68 | 49279 | 20728 | 63418947 |
Psoriasis | 44.75 | 10.84 | 7 | 49340 | 86950 | 63352725 |
Death | 43.82 | 10.84 | 147 | 49200 | 374234 | 63065441 |
Blood pressure increased | 43.72 | 10.84 | 37 | 49310 | 162025 | 63277650 |
Hypophagia | 43.30 | 10.84 | 83 | 49264 | 31176 | 63408499 |
Confusional state | 43.16 | 10.84 | 323 | 49024 | 236057 | 63203618 |
Genital ulceration | 43.15 | 10.84 | 17 | 49330 | 638 | 63439037 |
Mouth swelling | 43.04 | 10.84 | 33 | 49314 | 4707 | 63434968 |
Deep vein thrombosis | 42.87 | 10.84 | 153 | 49194 | 83647 | 63356028 |
Oral pain | 42.58 | 10.84 | 78 | 49269 | 28316 | 63411359 |
Pemphigus | 42.56 | 10.84 | 48 | 49299 | 183678 | 63255997 |
Macular degeneration | 41.77 | 10.84 | 71 | 49276 | 24305 | 63415370 |
Swollen tongue | 41.73 | 10.84 | 87 | 49260 | 34713 | 63404962 |
Urosepsis | 41.49 | 10.84 | 61 | 49286 | 18463 | 63421212 |
Thrombocytopenia | 41.45 | 10.84 | 229 | 49118 | 150928 | 63288747 |
Drug reaction with eosinophilia and systemic symptoms | 41.05 | 10.84 | 85 | 49262 | 33751 | 63405924 |
Intentional overdose | 40.44 | 10.84 | 5 | 49342 | 74147 | 63365528 |
Fear of eating | 39.89 | 10.84 | 14 | 49333 | 378 | 63439297 |
Superinfection | 39.85 | 10.84 | 25 | 49322 | 2582 | 63437093 |
Drug interaction | 39.54 | 10.84 | 309 | 49038 | 228822 | 63210853 |
Renal failure | 38.31 | 10.84 | 187 | 49160 | 117465 | 63322210 |
Genital pain | 37.98 | 10.84 | 14 | 49333 | 437 | 63439238 |
Psoriatic arthropathy | 37.81 | 10.84 | 12 | 49335 | 91508 | 63348167 |
Anaemia | 37.79 | 10.84 | 371 | 48976 | 293059 | 63146616 |
Bone marrow failure | 37.21 | 10.84 | 75 | 49272 | 29215 | 63410460 |
Pain | 36.97 | 10.84 | 383 | 48964 | 740245 | 62699430 |
Crepitations | 36.86 | 10.84 | 38 | 49309 | 8002 | 63431673 |
Glossodynia | 35.97 | 10.84 | 52 | 49295 | 178824 | 63260851 |
Inappropriate schedule of product administration | 35.82 | 10.84 | 18 | 49329 | 103947 | 63335728 |
Blood creatinine increased | 35.62 | 10.84 | 149 | 49198 | 87695 | 63351980 |
Nasopharyngitis | 35.40 | 10.84 | 92 | 49255 | 254165 | 63185510 |
Agranulocytosis | 35.13 | 10.84 | 67 | 49280 | 25067 | 63414608 |
Abdominal pain | 34.89 | 10.84 | 365 | 48982 | 293091 | 63146584 |
Intentional product use issue | 34.73 | 10.84 | 29 | 49318 | 127863 | 63311812 |
Fibromyalgia | 34.66 | 10.84 | 139 | 49208 | 80281 | 63359394 |
Oral candidiasis | 34.65 | 10.84 | 63 | 49284 | 22735 | 63416940 |
Fall | 34.63 | 10.84 | 172 | 49175 | 392162 | 63047513 |
Arthropathy | 34.20 | 10.84 | 83 | 49264 | 234709 | 63204966 |
Injection site erythema | 34.20 | 10.84 | 11 | 49336 | 83163 | 63356512 |
Cushingoid | 33.42 | 10.84 | 37 | 49310 | 8448 | 63431227 |
Platelet count decreased | 32.54 | 10.84 | 177 | 49170 | 115945 | 63323730 |
Injection site reaction | 31.78 | 10.84 | 4 | 49343 | 58520 | 63381155 |
Pneumocystis jirovecii pneumonia | 31.30 | 10.84 | 51 | 49296 | 16863 | 63422812 |
Atelectasis | 30.94 | 10.84 | 58 | 49289 | 21425 | 63418250 |
Bacterial sepsis | 30.46 | 10.84 | 25 | 49322 | 3933 | 63435742 |
COVID-19 | 30.28 | 10.84 | 26 | 49321 | 113077 | 63326598 |
Deformity | 29.89 | 10.84 | 41 | 49306 | 11643 | 63428032 |
Transplant rejection | 29.37 | 10.84 | 39 | 49308 | 10741 | 63428934 |
Rash erythematous | 29.34 | 10.84 | 86 | 49261 | 42424 | 63397251 |
Angioedema | 29.33 | 10.84 | 93 | 49254 | 47872 | 63391803 |
Suicide attempt | 28.97 | 10.84 | 6 | 49341 | 60912 | 63378763 |
Infusion related reaction | 28.97 | 10.84 | 96 | 49251 | 245425 | 63194250 |
Complications of transplanted kidney | 28.68 | 10.84 | 20 | 49327 | 2466 | 63437209 |
Documented hypersensitivity to administered product | 28.55 | 10.84 | 12 | 49335 | 533 | 63439142 |
Neutropenic sepsis | 28.32 | 10.84 | 48 | 49299 | 16390 | 63423285 |
Parkinsonian rest tremor | 28.11 | 10.84 | 8 | 49339 | 106 | 63439569 |
HIV infection | 27.94 | 10.84 | 11 | 49336 | 412 | 63439263 |
Drug abuse | 27.41 | 10.84 | 11 | 49336 | 72507 | 63367168 |
Pulmonary toxicity | 26.98 | 10.84 | 35 | 49312 | 9420 | 63430255 |
Discomfort | 26.95 | 10.84 | 56 | 49291 | 167318 | 63272357 |
Herpes zoster | 26.79 | 10.84 | 131 | 49216 | 82331 | 63357344 |
Excessive eye blinking | 26.70 | 10.84 | 15 | 49332 | 1265 | 63438410 |
Arthralgia | 26.60 | 10.84 | 299 | 49048 | 569411 | 62870264 |
Rash pruritic | 26.27 | 10.84 | 104 | 49243 | 59695 | 63379980 |
Ureteric obstruction | 26.26 | 10.84 | 17 | 49330 | 1853 | 63437822 |
Vaginal discharge | 26.18 | 10.84 | 34 | 49313 | 9164 | 63430511 |
Cholecystitis chronic | 25.97 | 10.84 | 36 | 49311 | 10325 | 63429350 |
Synovial cyst | 25.78 | 10.84 | 36 | 49311 | 10397 | 63429278 |
Ocular hyperaemia | 25.75 | 10.84 | 59 | 49288 | 25085 | 63414590 |
Muscle twitching | 25.75 | 10.84 | 51 | 49296 | 19617 | 63420058 |
Blood pressure fluctuation | 25.56 | 10.84 | 3 | 49344 | 46314 | 63393361 |
Infection | 25.33 | 10.84 | 281 | 49066 | 228892 | 63210783 |
Treatment failure | 24.75 | 10.84 | 76 | 49271 | 198967 | 63240708 |
Meningoencephalitis herpetic | 24.60 | 10.84 | 14 | 49333 | 1210 | 63438465 |
Flank pain | 24.50 | 10.84 | 45 | 49302 | 16365 | 63423310 |
Potentiating drug interaction | 24.46 | 10.84 | 23 | 49324 | 4333 | 63435342 |
Vulvovaginal candidiasis | 24.32 | 10.84 | 20 | 49327 | 3155 | 63436520 |
Wrong technique in product usage process | 24.32 | 10.84 | 9 | 49338 | 62331 | 63377344 |
Feeling jittery | 24.24 | 10.84 | 40 | 49307 | 13363 | 63426312 |
Bacterial test positive | 24.18 | 10.84 | 25 | 49322 | 5282 | 63434393 |
Hepatic cytolysis | 23.96 | 10.84 | 43 | 49304 | 15364 | 63424311 |
Rectal haemorrhage | 23.78 | 10.84 | 88 | 49259 | 48942 | 63390733 |
Rheumatoid arthritis | 23.69 | 10.84 | 109 | 49238 | 253710 | 63185965 |
Wound | 23.54 | 10.84 | 58 | 49289 | 163205 | 63276470 |
Influenza | 23.47 | 10.84 | 30 | 49317 | 108692 | 63330983 |
Mucosal inflammation | 23.41 | 10.84 | 85 | 49262 | 46843 | 63392832 |
Toxicity to various agents | 23.18 | 10.84 | 106 | 49241 | 247144 | 63192531 |
Rheumatoid factor positive | 23.08 | 10.84 | 19 | 49328 | 84387 | 63355288 |
Contraindicated product administered | 23.07 | 10.84 | 89 | 49258 | 217559 | 63222116 |
Seizure | 22.92 | 10.84 | 179 | 49168 | 132455 | 63307220 |
Multiple organ dysfunction syndrome | 22.79 | 10.84 | 96 | 49251 | 56656 | 63383019 |
Chronic sinusitis | 22.79 | 10.84 | 38 | 49309 | 12805 | 63426870 |
Injection site bruising | 22.43 | 10.84 | 3 | 49344 | 41907 | 63397768 |
Vomiting | 22.38 | 10.84 | 581 | 48766 | 559036 | 62880639 |
Blindness cortical | 22.36 | 10.84 | 10 | 49337 | 517 | 63439158 |
Pregnancy with injectable contraceptive | 22.26 | 10.84 | 7 | 49340 | 133 | 63439542 |
Urinary tract infection | 22.13 | 10.84 | 308 | 49039 | 264376 | 63175299 |
Eye pain | 21.95 | 10.84 | 67 | 49280 | 33787 | 63405888 |
Antinuclear antibody positive | 21.88 | 10.84 | 29 | 49318 | 7970 | 63431705 |
Red blood cell sedimentation rate increased | 21.61 | 10.84 | 4 | 49343 | 43978 | 63395697 |
Cystitis noninfective | 21.59 | 10.84 | 12 | 49335 | 991 | 63438684 |
Acquired immunodeficiency syndrome | 20.85 | 10.84 | 6 | 49341 | 83 | 63439592 |
Hepatitis fulminant | 20.82 | 10.84 | 19 | 49328 | 3445 | 63436230 |
Trimethylaminuria | 20.80 | 10.84 | 7 | 49340 | 166 | 63439509 |
Renal tubular disorder | 20.76 | 10.84 | 17 | 49330 | 2665 | 63437010 |
Deafness transitory | 20.76 | 10.84 | 15 | 49332 | 1955 | 63437720 |
Blood sodium decreased | 20.65 | 10.84 | 53 | 49294 | 24199 | 63415476 |
Clostridial infection | 20.57 | 10.84 | 21 | 49326 | 4371 | 63435304 |
Body mass index decreased | 20.50 | 10.84 | 9 | 49338 | 445 | 63439230 |
Pulmonary embolism | 20.45 | 10.84 | 158 | 49189 | 116526 | 63323149 |
White blood cell count decreased | 20.44 | 10.84 | 181 | 49166 | 138923 | 63300752 |
Weight increased | 20.39 | 10.84 | 119 | 49228 | 260673 | 63179002 |
Effusion | 20.24 | 10.84 | 14 | 49333 | 1704 | 63437971 |
Bronchopulmonary aspergillosis | 20.16 | 10.84 | 29 | 49318 | 8606 | 63431069 |
Injection site swelling | 20.07 | 10.84 | 6 | 49341 | 47566 | 63392109 |
Blood pressure systolic increased | 19.96 | 10.84 | 6 | 49341 | 47391 | 63392284 |
Hospitalisation | 19.94 | 10.84 | 22 | 49325 | 85059 | 63354616 |
Foaming at mouth | 19.89 | 10.84 | 12 | 49335 | 1156 | 63438519 |
Palmar erythema | 19.88 | 10.84 | 14 | 49333 | 1753 | 63437922 |
Cholelithiasis | 19.78 | 10.84 | 77 | 49270 | 43848 | 63395827 |
Pseudomonas infection | 19.66 | 10.84 | 33 | 49314 | 11180 | 63428495 |
Osteoporosis | 19.63 | 10.84 | 10 | 49337 | 57328 | 63382347 |
Renal tubular necrosis | 19.56 | 10.84 | 34 | 49313 | 11844 | 63427831 |
Soft tissue swelling | 19.19 | 10.84 | 12 | 49335 | 1232 | 63438443 |
Blood cholesterol increased | 19.16 | 10.84 | 132 | 49215 | 93900 | 63345775 |
Septic shock | 18.95 | 10.84 | 102 | 49245 | 66527 | 63373148 |
Inappropriate antidiuretic hormone secretion | 18.94 | 10.84 | 39 | 49308 | 15423 | 63424252 |
Intentional product misuse | 18.89 | 10.84 | 12 | 49335 | 60905 | 63378770 |
Loss of personal independence in daily activities | 18.85 | 10.84 | 29 | 49318 | 97261 | 63342414 |
Leukoencephalopathy | 18.70 | 10.84 | 20 | 49327 | 4393 | 63435282 |
Tubulointerstitial nephritis | 18.53 | 10.84 | 45 | 49302 | 19858 | 63419817 |
Libido disorder | 18.42 | 10.84 | 5 | 49342 | 55 | 63439620 |
Aplasia pure red cell | 18.42 | 10.84 | 20 | 49327 | 4467 | 63435208 |
Tenosynovitis | 18.33 | 10.84 | 36 | 49311 | 13759 | 63425916 |
Hepatic enzyme increased | 18.22 | 10.84 | 88 | 49259 | 202240 | 63237435 |
Fluid retention | 18.18 | 10.84 | 12 | 49335 | 59674 | 63380001 |
Arthritis | 18.16 | 10.84 | 153 | 49194 | 115768 | 63323907 |
Chemotherapeutic drug level increased | 18.13 | 10.84 | 6 | 49341 | 135 | 63439540 |
Immune reconstitution inflammatory syndrome | 18.11 | 10.84 | 23 | 49324 | 6061 | 63433614 |
Bone density decreased | 18.06 | 10.84 | 37 | 49310 | 14575 | 63425100 |
Urine output decreased | 18.02 | 10.84 | 32 | 49315 | 11338 | 63428337 |
Pericarditis | 17.99 | 10.84 | 48 | 49299 | 131531 | 63308144 |
No adverse event | 17.88 | 10.84 | 5 | 49342 | 41400 | 63398275 |
Haemoglobin decreased | 17.75 | 10.84 | 182 | 49165 | 145303 | 63294372 |
Neutropenia | 17.72 | 10.84 | 211 | 49136 | 174794 | 63264881 |
Dehydration | 17.54 | 10.84 | 209 | 49138 | 173145 | 63266530 |
Device expulsion | 17.54 | 10.84 | 3 | 49344 | 34919 | 63404756 |
Sinusitis | 17.41 | 10.84 | 104 | 49243 | 226549 | 63213126 |
Breast cancer | 17.23 | 10.84 | 8 | 49339 | 48375 | 63391300 |
Physical assault | 17.07 | 10.84 | 10 | 49337 | 913 | 63438762 |
Hiccups | 16.98 | 10.84 | 14 | 49333 | 2217 | 63437458 |
Angiodermatitis | 16.94 | 10.84 | 5 | 49342 | 76 | 63439599 |
Dermatitis exfoliative | 16.83 | 10.84 | 21 | 49326 | 5438 | 63434237 |
Lethargy | 16.79 | 10.84 | 87 | 49260 | 55920 | 63383755 |
Mental status changes | 16.70 | 10.84 | 68 | 49279 | 39531 | 63400144 |
Pseudomembranous colitis | 16.65 | 10.84 | 16 | 49331 | 3096 | 63436579 |
Nasal congestion | 16.49 | 10.84 | 16 | 49331 | 65644 | 63374031 |
Adverse event | 16.35 | 10.84 | 17 | 49330 | 67542 | 63372133 |
Joint effusion | 16.34 | 10.84 | 39 | 49308 | 17021 | 63422654 |
Cogwheel rigidity | 16.34 | 10.84 | 13 | 49334 | 1957 | 63437718 |
Immunosuppressant drug level increased | 16.32 | 10.84 | 17 | 49330 | 3621 | 63436054 |
Febrile bone marrow aplasia | 16.23 | 10.84 | 24 | 49323 | 7301 | 63432374 |
Antinuclear antibody | 16.20 | 10.84 | 8 | 49339 | 518 | 63439157 |
Gastrointestinal pain | 16.12 | 10.84 | 28 | 49319 | 9748 | 63429927 |
Liver function test increased | 16.09 | 10.84 | 3 | 49344 | 32808 | 63406867 |
Synovial disorder | 15.91 | 10.84 | 13 | 49334 | 2032 | 63437643 |
Blood culture positive | 15.87 | 10.84 | 19 | 49328 | 4716 | 63434959 |
Liver disorder | 15.82 | 10.84 | 83 | 49264 | 53604 | 63386071 |
Purpura senile | 15.69 | 10.84 | 8 | 49339 | 555 | 63439120 |
Meningitis aseptic | 15.59 | 10.84 | 19 | 49328 | 4804 | 63434871 |
Left ventricular dysfunction | 15.59 | 10.84 | 31 | 49316 | 11957 | 63427718 |
Tarsal tunnel syndrome | 15.54 | 10.84 | 8 | 49339 | 566 | 63439109 |
Haemorrhoids | 15.46 | 10.84 | 45 | 49302 | 22105 | 63417570 |
Migraine | 15.45 | 10.84 | 36 | 49311 | 103310 | 63336365 |
Anti-cyclic citrullinated peptide antibody positive | 15.43 | 10.84 | 43 | 49304 | 116169 | 63323506 |
Vestibular disorder | 15.32 | 10.84 | 11 | 49336 | 1420 | 63438255 |
Proctitis | 15.31 | 10.84 | 20 | 49327 | 5421 | 63434254 |
Paraesthesia oral | 15.29 | 10.84 | 41 | 49306 | 19215 | 63420460 |
Blood alkaline phosphatase increased | 15.21 | 10.84 | 70 | 49277 | 42897 | 63396778 |
Oliguria | 14.92 | 10.84 | 26 | 49321 | 9075 | 63430600 |
Subdural haemorrhage | 14.77 | 10.84 | 15 | 49332 | 3103 | 63436572 |
Acute respiratory distress syndrome | 14.72 | 10.84 | 46 | 49301 | 23488 | 63416187 |
Impaired work ability | 14.68 | 10.84 | 38 | 49309 | 17437 | 63422238 |
Jaundice | 14.60 | 10.84 | 53 | 49294 | 29198 | 63410477 |
Lung transplant rejection | 14.45 | 10.84 | 9 | 49338 | 918 | 63438757 |
Malaise | 14.37 | 10.84 | 424 | 48923 | 415530 | 63024145 |
Procedural pain | 14.28 | 10.84 | 43 | 49304 | 21526 | 63418149 |
Lung disorder | 14.25 | 10.84 | 90 | 49257 | 62171 | 63377504 |
Hepatitis | 14.22 | 10.84 | 65 | 49282 | 39723 | 63399952 |
Cushing's syndrome | 14.19 | 10.84 | 8 | 49339 | 679 | 63438996 |
Vaginal flatulence | 14.09 | 10.84 | 15 | 49332 | 3278 | 63436397 |
Hepatic failure | 14.07 | 10.84 | 60 | 49287 | 35596 | 63404079 |
Citrobacter infection | 13.99 | 10.84 | 7 | 49340 | 466 | 63439209 |
Pain in extremity | 13.89 | 10.84 | 178 | 49169 | 331308 | 63108367 |
Genital burning sensation | 13.88 | 10.84 | 6 | 49341 | 286 | 63439389 |
Tonsillar hypertrophy | 13.81 | 10.84 | 9 | 49338 | 992 | 63438683 |
Alanine aminotransferase increased | 13.71 | 10.84 | 132 | 49215 | 103638 | 63336037 |
Pustule | 13.64 | 10.84 | 11 | 49336 | 1688 | 63437987 |
Asthma | 13.61 | 10.84 | 52 | 49295 | 127509 | 63312166 |
Unevaluable event | 13.52 | 10.84 | 12 | 49335 | 51374 | 63388301 |
Hypovolaemic shock | 13.19 | 10.84 | 20 | 49327 | 6221 | 63433454 |
Hydronephrosis | 13.18 | 10.84 | 27 | 49320 | 10635 | 63429040 |
Depression | 13.14 | 10.84 | 94 | 49253 | 196398 | 63243277 |
Cataract | 13.09 | 10.84 | 15 | 49332 | 57038 | 63382637 |
Herpes simplex viraemia | 13.07 | 10.84 | 6 | 49341 | 330 | 63439345 |
Stress | 13.03 | 10.84 | 20 | 49327 | 67147 | 63372528 |
Areflexia | 12.98 | 10.84 | 14 | 49333 | 3104 | 63436571 |
Axillary vein thrombosis | 12.92 | 10.84 | 6 | 49341 | 339 | 63439336 |
Altered visual depth perception | 12.85 | 10.84 | 6 | 49341 | 343 | 63439332 |
Memory impairment | 12.81 | 10.84 | 40 | 49307 | 104218 | 63335457 |
HIV wasting syndrome | 12.80 | 10.84 | 3 | 49344 | 17 | 63439658 |
Dermatitis allergic | 12.79 | 10.84 | 33 | 49314 | 15115 | 63424560 |
Muscle haemorrhage | 12.76 | 10.84 | 14 | 49333 | 3165 | 63436510 |
Sepsis | 12.70 | 10.84 | 178 | 49169 | 152945 | 63286730 |
Disseminated intravascular coagulation | 12.63 | 10.84 | 38 | 49309 | 19013 | 63420662 |
Neutrophil count decreased | 12.58 | 10.84 | 81 | 49266 | 56325 | 63383350 |
Hypoaesthesia | 12.54 | 10.84 | 78 | 49269 | 168315 | 63271360 |
Mobility decreased | 12.54 | 10.84 | 50 | 49297 | 121109 | 63318566 |
Aspartate aminotransferase increased | 12.50 | 10.84 | 116 | 49231 | 90161 | 63349514 |
Porphyria acute | 12.49 | 10.84 | 9 | 49338 | 1168 | 63438507 |
Dialysis | 12.42 | 10.84 | 26 | 49321 | 10401 | 63429274 |
Escherichia test positive | 12.27 | 10.84 | 12 | 49335 | 2372 | 63437303 |
Gait disturbance | 12.07 | 10.84 | 88 | 49259 | 183090 | 63256585 |
Graft versus host disease | 11.98 | 10.84 | 20 | 49327 | 6743 | 63432932 |
Lip ulceration | 11.85 | 10.84 | 11 | 49336 | 2039 | 63437636 |
Ataxia | 11.71 | 10.84 | 32 | 49315 | 15163 | 63424512 |
Nail infection | 11.70 | 10.84 | 12 | 49335 | 2511 | 63437164 |
Plasma cell myeloma | 11.62 | 10.84 | 57 | 49290 | 35848 | 63403827 |
Cytomegalovirus test positive | 11.61 | 10.84 | 13 | 49334 | 3005 | 63436670 |
Renal tubular acidosis | 11.60 | 10.84 | 10 | 49337 | 1682 | 63437993 |
Vaginal ulceration | 11.58 | 10.84 | 6 | 49341 | 430 | 63439245 |
Pleural effusion | 11.55 | 10.84 | 117 | 49230 | 93093 | 63346582 |
Abnormal loss of weight | 11.47 | 10.84 | 18 | 49329 | 5764 | 63433911 |
Drug hypersensitivity | 11.35 | 10.84 | 319 | 49028 | 310368 | 63129307 |
Intentional self-injury | 11.28 | 10.84 | 3 | 49344 | 25684 | 63413991 |
Defaecation urgency | 11.21 | 10.84 | 15 | 49332 | 4160 | 63435515 |
Hypersensitivity pneumonitis | 11.21 | 10.84 | 12 | 49335 | 2638 | 63437037 |
Circulatory collapse | 11.16 | 10.84 | 40 | 49307 | 21898 | 63417777 |
Eye irritation | 11.13 | 10.84 | 40 | 49307 | 21931 | 63417744 |
Retinal detachment | 11.05 | 10.84 | 18 | 49329 | 5951 | 63433724 |
Blood folate decreased | 11.03 | 10.84 | 7 | 49340 | 737 | 63438938 |
Functional gastrointestinal disorder | 10.98 | 10.84 | 15 | 49332 | 4244 | 63435431 |
Apraxia | 10.97 | 10.84 | 10 | 49337 | 1811 | 63437864 |
Joint range of motion decreased | 10.87 | 10.84 | 52 | 49295 | 32376 | 63407299 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 178.29 | 11.27 | 118 | 37687 | 419406 | 34499720 |
Hyperkalaemia | 159.03 | 11.27 | 276 | 37529 | 69113 | 34850013 |
Drug ineffective | 156.23 | 11.27 | 159 | 37646 | 456592 | 34462534 |
Pyrexia | 154.26 | 11.27 | 739 | 37066 | 332274 | 34586852 |
Acute kidney injury | 126.30 | 11.27 | 656 | 37149 | 304332 | 34614794 |
Neutropenia | 110.14 | 11.27 | 396 | 37409 | 156382 | 34762744 |
Death | 95.25 | 11.27 | 179 | 37626 | 397870 | 34521256 |
Blood creatinine increased | 92.10 | 11.27 | 268 | 37537 | 94708 | 34824418 |
Pancytopenia | 87.02 | 11.27 | 263 | 37542 | 94894 | 34824232 |
Drug abuse | 86.98 | 11.27 | 5 | 37800 | 99091 | 34820035 |
Stevens-Johnson syndrome | 86.90 | 11.27 | 104 | 37701 | 18535 | 34900591 |
Immune reconstitution inflammatory syndrome | 85.60 | 11.27 | 73 | 37732 | 8686 | 34910440 |
Cytomegalovirus infection | 81.88 | 11.27 | 120 | 37685 | 26015 | 34893111 |
Completed suicide | 75.08 | 11.27 | 9 | 37796 | 98159 | 34820967 |
Product dose omission issue | 70.42 | 11.27 | 21 | 37784 | 119690 | 34799436 |
Transplant rejection | 66.14 | 11.27 | 68 | 37737 | 10243 | 34908883 |
Product use in unapproved indication | 53.89 | 11.27 | 30 | 37775 | 117469 | 34801657 |
Hepatic cytolysis | 53.48 | 11.27 | 72 | 37733 | 14424 | 34904702 |
Product use issue | 53.07 | 11.27 | 4 | 37801 | 63212 | 34855914 |
Kidney transplant rejection | 50.92 | 11.27 | 51 | 37754 | 7446 | 34911680 |
Thrombocytopenia | 50.45 | 11.27 | 315 | 37490 | 155932 | 34763194 |
Cellulitis enterococcal | 47.80 | 11.27 | 13 | 37792 | 100 | 34919026 |
Agranulocytosis | 47.15 | 11.27 | 89 | 37716 | 23732 | 34895394 |
Leukopenia | 45.91 | 11.27 | 161 | 37644 | 62695 | 34856431 |
Fatigue | 45.17 | 11.27 | 227 | 37578 | 370426 | 34548700 |
Renal tubular necrosis | 43.43 | 11.27 | 68 | 37737 | 15612 | 34903514 |
Inappropriate schedule of product administration | 42.37 | 11.27 | 8 | 37797 | 62288 | 34856838 |
Pneumocystis jirovecii pneumonia | 41.97 | 11.27 | 76 | 37729 | 19634 | 34899492 |
Aspartate aminotransferase increased | 41.47 | 11.27 | 164 | 37641 | 67619 | 34851507 |
Pre-engraftment immune reaction | 40.06 | 11.27 | 11 | 37794 | 88 | 34919038 |
Haemodialysis | 39.93 | 11.27 | 53 | 37752 | 10473 | 34908653 |
Alanine aminotransferase increased | 37.56 | 11.27 | 180 | 37625 | 80635 | 34838491 |
Blood lactate dehydrogenase increased | 37.23 | 11.27 | 79 | 37726 | 22911 | 34896215 |
Blood bilirubin increased | 36.99 | 11.27 | 108 | 37697 | 38188 | 34880938 |
Hepatitis | 36.26 | 11.27 | 80 | 37725 | 23824 | 34895302 |
Cholestasis | 36.25 | 11.27 | 86 | 37719 | 26862 | 34892264 |
Lymphocyte count decreased | 35.79 | 11.27 | 77 | 37728 | 22545 | 34896581 |
Anal inflammation | 34.51 | 11.27 | 20 | 37785 | 1280 | 34917846 |
Blood urea increased | 33.62 | 11.27 | 90 | 37715 | 30274 | 34888852 |
Weight increased | 33.18 | 11.27 | 31 | 37774 | 93002 | 34826124 |
Toxicity to various agents | 32.26 | 11.27 | 110 | 37695 | 200252 | 34718874 |
Osteoporotic fracture | 32.17 | 11.27 | 18 | 37787 | 1077 | 34918049 |
Respiratory tract infection bacterial | 31.09 | 11.27 | 21 | 37784 | 1761 | 34917365 |
Respiratory tract infection viral | 30.97 | 11.27 | 24 | 37781 | 2493 | 34916633 |
SARS-CoV-2 test negative | 30.60 | 11.27 | 17 | 37788 | 1003 | 34918123 |
Rash | 29.90 | 11.27 | 370 | 37435 | 222382 | 34696744 |
Aplasia pure red cell | 29.87 | 11.27 | 35 | 37770 | 6097 | 34913029 |
Platelet count decreased | 29.50 | 11.27 | 226 | 37579 | 119491 | 34799635 |
Rash maculo-papular | 29.18 | 11.27 | 82 | 37723 | 28369 | 34890757 |
Proctalgia | 28.43 | 11.27 | 33 | 37772 | 5690 | 34913436 |
Plasma cell myeloma | 28.40 | 11.27 | 105 | 37700 | 41932 | 34877194 |
Hospitalisation | 28.36 | 11.27 | 13 | 37792 | 56889 | 34862237 |
Toxic skin eruption | 28.29 | 11.27 | 47 | 37758 | 11338 | 34907788 |
Encephalitis viral | 27.88 | 11.27 | 17 | 37788 | 1195 | 34917931 |
Liver transplant rejection | 27.82 | 11.27 | 21 | 37784 | 2098 | 34917028 |
Fall | 27.74 | 11.27 | 119 | 37686 | 202766 | 34716360 |
Dialysis | 27.49 | 11.27 | 46 | 37759 | 11162 | 34907964 |
Blood alkaline phosphatase increased | 27.35 | 11.27 | 85 | 37720 | 31090 | 34888036 |
Body temperature increased | 27.34 | 11.27 | 59 | 37746 | 17309 | 34901817 |
Renal failure | 27.06 | 11.27 | 237 | 37568 | 130320 | 34788806 |
HIV infection | 26.32 | 11.27 | 17 | 37788 | 1322 | 34917804 |
Blood antidiuretic hormone increased | 26.31 | 11.27 | 7 | 37798 | 49 | 34919077 |
Intestinal intraepithelial lymphocytes increased | 26.20 | 11.27 | 9 | 37796 | 161 | 34918965 |
Cerebrovascular accident | 26.07 | 11.27 | 32 | 37773 | 84779 | 34834347 |
Therapeutic product effect incomplete | 26.05 | 11.27 | 11 | 37794 | 50530 | 34868596 |
Asthma | 25.95 | 11.27 | 7 | 37798 | 42649 | 34876477 |
Liver function test abnormal | 25.68 | 11.27 | 83 | 37722 | 30991 | 34888135 |
Hepatitis cholestatic | 25.62 | 11.27 | 37 | 37768 | 7910 | 34911216 |
Drug reaction with eosinophilia and systemic symptoms | 25.34 | 11.27 | 86 | 37719 | 32926 | 34886200 |
Acquired immunodeficiency syndrome | 25.33 | 11.27 | 12 | 37793 | 506 | 34918620 |
Chills | 25.23 | 11.27 | 162 | 37643 | 80881 | 34838245 |
Intentional overdose | 25.05 | 11.27 | 8 | 37797 | 43666 | 34875460 |
Intentional product use issue | 25.00 | 11.27 | 17 | 37788 | 59799 | 34859327 |
Pneumonia cytomegaloviral | 24.94 | 11.27 | 23 | 37782 | 3031 | 34916095 |
Rash morbilliform | 24.73 | 11.27 | 23 | 37782 | 3064 | 34916062 |
Kaposi's sarcoma | 24.55 | 11.27 | 14 | 37791 | 869 | 34918257 |
Aspergillus infection | 24.51 | 11.27 | 46 | 37759 | 12208 | 34906918 |
Jaundice | 24.42 | 11.27 | 83 | 37722 | 31799 | 34887327 |
Proteus infection | 24.13 | 11.27 | 15 | 37790 | 1091 | 34918035 |
Graft versus host disease | 24.10 | 11.27 | 42 | 37763 | 10527 | 34908599 |
Bone marrow failure | 24.05 | 11.27 | 78 | 37727 | 29175 | 34889951 |
Lymphocele | 23.69 | 11.27 | 16 | 37789 | 1341 | 34917785 |
Blood potassium increased | 23.67 | 11.27 | 54 | 37751 | 16441 | 34902685 |
Cryptitis | 23.32 | 11.27 | 9 | 37796 | 227 | 34918899 |
Hepatomegaly | 23.30 | 11.27 | 41 | 37764 | 10355 | 34908771 |
Tubulointerstitial nephritis | 22.95 | 11.27 | 62 | 37743 | 20962 | 34898164 |
Culture urine positive | 22.90 | 11.27 | 15 | 37790 | 1195 | 34917931 |
Injection site pain | 22.63 | 11.27 | 7 | 37798 | 38998 | 34880128 |
Peripheral swelling | 22.37 | 11.27 | 30 | 37775 | 76511 | 34842615 |
Hepatosplenomegaly | 22.34 | 11.27 | 25 | 37780 | 4144 | 34914982 |
Renal papillary necrosis | 22.28 | 11.27 | 8 | 37797 | 164 | 34918962 |
Nasopharyngitis | 21.93 | 11.27 | 26 | 37779 | 69942 | 34849184 |
Intentional product misuse | 21.84 | 11.27 | 11 | 37794 | 45600 | 34873526 |
Foetal exposure during pregnancy | 21.81 | 11.27 | 7 | 37798 | 38094 | 34881032 |
SARS-CoV-2 antibody test positive | 21.28 | 11.27 | 10 | 37795 | 414 | 34918712 |
Treatment failure | 21.28 | 11.27 | 12 | 37793 | 46685 | 34872441 |
Leukaemia recurrent | 21.19 | 11.27 | 16 | 37789 | 1599 | 34917527 |
Microvillous inclusion disease | 21.10 | 11.27 | 8 | 37797 | 192 | 34918934 |
Drug intolerance | 21.06 | 11.27 | 20 | 37785 | 59550 | 34859576 |
Neutrophil count decreased | 21.02 | 11.27 | 110 | 37695 | 50994 | 34868132 |
Motion sickness | 20.99 | 11.27 | 8 | 37797 | 195 | 34918931 |
Mental status changes | 20.79 | 11.27 | 89 | 37716 | 37994 | 34881132 |
Therapeutic product effect decreased | 20.58 | 11.27 | 6 | 37799 | 34737 | 34884389 |
Dyspnoea | 20.43 | 11.27 | 286 | 37519 | 376496 | 34542630 |
White blood cell count decreased | 20.15 | 11.27 | 174 | 37631 | 95271 | 34823855 |
Haemorrhoids | 20.12 | 11.27 | 47 | 37758 | 14528 | 34904598 |
Dermatitis exfoliative | 20.08 | 11.27 | 30 | 37775 | 6609 | 34912517 |
Probiotic therapy | 19.99 | 11.27 | 7 | 37798 | 133 | 34918993 |
Wrong technique in product usage process | 19.92 | 11.27 | 7 | 37798 | 35979 | 34883147 |
Gamma-glutamyltransferase increased | 19.73 | 11.27 | 73 | 37732 | 29158 | 34889968 |
Human herpesvirus 6 infection | 19.63 | 11.27 | 17 | 37788 | 2064 | 34917062 |
Clonal haematopoiesis | 19.23 | 11.27 | 6 | 37799 | 78 | 34919048 |
Biopsy liver abnormal | 19.16 | 11.27 | 7 | 37798 | 151 | 34918975 |
Joint swelling | 19.04 | 11.27 | 22 | 37783 | 59868 | 34859258 |
Apoptosis | 18.52 | 11.27 | 9 | 37796 | 402 | 34918724 |
Lung infiltration | 18.24 | 11.27 | 42 | 37763 | 12863 | 34906263 |
Serum sickness | 18.18 | 11.27 | 16 | 37789 | 1984 | 34917142 |
Ureteric obstruction | 17.99 | 11.27 | 13 | 37792 | 1215 | 34917911 |
Biopsy | 17.64 | 11.27 | 8 | 37797 | 305 | 34918821 |
Viral test positive | 17.29 | 11.27 | 7 | 37798 | 201 | 34918925 |
Haemoglobin decreased | 17.20 | 11.27 | 203 | 37602 | 120569 | 34798557 |
Rheumatoid arthritis | 17.17 | 11.27 | 10 | 37795 | 38228 | 34880898 |
Myocardial infarction | 17.16 | 11.27 | 70 | 37735 | 121015 | 34798111 |
Chronic lymphocytic leukaemia | 17.12 | 11.27 | 22 | 37783 | 4210 | 34914916 |
Phlebitis | 17.06 | 11.27 | 21 | 37784 | 3849 | 34915277 |
Renal tubular disorder | 17.03 | 11.27 | 23 | 37782 | 4620 | 34914506 |
Dizziness | 16.90 | 11.27 | 153 | 37652 | 218368 | 34700758 |
Escherichia urinary tract infection | 16.87 | 11.27 | 20 | 37785 | 3526 | 34915600 |
Suicide attempt | 16.50 | 11.27 | 11 | 37794 | 39105 | 34880021 |
Oesophageal candidiasis | 16.46 | 11.27 | 22 | 37783 | 4374 | 34914752 |
Psoriasis | 16.26 | 11.27 | 11 | 37794 | 38801 | 34880325 |
Syncope | 16.24 | 11.27 | 48 | 37757 | 91403 | 34827723 |
Culture stool positive | 15.97 | 11.27 | 7 | 37798 | 246 | 34918880 |
Enterovirus infection | 15.74 | 11.27 | 11 | 37794 | 975 | 34918151 |
Idiopathic pneumonia syndrome | 15.53 | 11.27 | 7 | 37798 | 263 | 34918863 |
Toxic epidermal necrolysis | 15.40 | 11.27 | 55 | 37750 | 21591 | 34897535 |
Dehydration | 15.34 | 11.27 | 211 | 37594 | 129758 | 34789368 |
Vomiting | 15.33 | 11.27 | 363 | 37442 | 247258 | 34671868 |
Febrile neutropenia | 15.28 | 11.27 | 220 | 37585 | 136629 | 34782497 |
Cytomegalovirus chorioretinitis | 15.06 | 11.27 | 19 | 37786 | 3570 | 34915556 |
Erythema infectiosum | 15.03 | 11.27 | 6 | 37799 | 166 | 34918960 |
Blood culture positive | 15.03 | 11.27 | 22 | 37783 | 4761 | 34914365 |
Liver transplant | 14.97 | 11.27 | 16 | 37789 | 2518 | 34916608 |
Parkinsonism hyperpyrexia syndrome | 14.85 | 11.27 | 5 | 37800 | 84 | 34919042 |
Orbital haemorrhage | 14.79 | 11.27 | 4 | 37801 | 30 | 34919096 |
Myositis | 14.61 | 11.27 | 37 | 37768 | 12033 | 34907093 |
HIV wasting syndrome | 14.58 | 11.27 | 5 | 37800 | 89 | 34919037 |
Photosensitivity reaction | 14.45 | 11.27 | 34 | 37771 | 10560 | 34908566 |
Loss of personal independence in daily activities | 14.45 | 11.27 | 9 | 37796 | 33170 | 34885956 |
Lymphadenopathy | 14.38 | 11.27 | 65 | 37740 | 28398 | 34890728 |
Renal tubular acidosis | 14.34 | 11.27 | 15 | 37790 | 2304 | 34916822 |
Drug ineffective for unapproved indication | 14.22 | 11.27 | 4 | 37801 | 23711 | 34895415 |
Complications of transplanted kidney | 14.19 | 11.27 | 21 | 37784 | 4588 | 34914538 |
Vena cava injury | 13.99 | 11.27 | 7 | 37798 | 333 | 34918793 |
Light chain analysis decreased | 13.96 | 11.27 | 4 | 37801 | 38 | 34919088 |
Lymphocytic infiltration | 13.86 | 11.27 | 9 | 37796 | 706 | 34918420 |
Wound evisceration | 13.64 | 11.27 | 5 | 37800 | 109 | 34919017 |
Acute graft versus host disease in skin | 13.63 | 11.27 | 22 | 37783 | 5179 | 34913947 |
Peripheral motor neuropathy | 13.48 | 11.27 | 13 | 37792 | 1813 | 34917313 |
Hepatic steatosis | 13.36 | 11.27 | 47 | 37758 | 18315 | 34900811 |
Mycobacterium avium complex infection | 13.35 | 11.27 | 15 | 37790 | 2496 | 34916630 |
Thrombotic microangiopathy | 13.30 | 11.27 | 33 | 37772 | 10597 | 34908529 |
Hepatitis A antibody positive | 13.27 | 11.27 | 4 | 37801 | 46 | 34919080 |
Sleep disorder | 13.25 | 11.27 | 9 | 37796 | 31679 | 34887447 |
C-reactive protein increased | 13.23 | 11.27 | 102 | 37703 | 53996 | 34865130 |
Cytomegalovirus test | 13.19 | 11.27 | 4 | 37801 | 47 | 34919079 |
Stent removal | 12.88 | 11.27 | 3 | 37802 | 11 | 34919115 |
Enterococcal infection | 12.84 | 11.27 | 30 | 37775 | 9276 | 34909850 |
Transplant dysfunction | 12.70 | 11.27 | 15 | 37790 | 2634 | 34916492 |
Cystic lymphangioma | 12.68 | 11.27 | 3 | 37802 | 12 | 34919114 |
Optic neuropathy | 12.67 | 11.27 | 13 | 37792 | 1952 | 34917174 |
Therapeutic product effect prolonged | 12.62 | 11.27 | 6 | 37799 | 255 | 34918871 |
Cytomegalovirus viraemia | 12.57 | 11.27 | 26 | 37779 | 7404 | 34911722 |
Hepatitis B antibody positive | 12.55 | 11.27 | 4 | 37801 | 56 | 34919070 |
Immunosuppressant drug level increased | 12.45 | 11.27 | 23 | 37782 | 6032 | 34913094 |
Malignant neoplasm progression | 12.40 | 11.27 | 51 | 37754 | 87995 | 34831131 |
Blood calcium decreased | 12.30 | 11.27 | 31 | 37774 | 10053 | 34909073 |
Wound infection | 12.25 | 11.27 | 25 | 37780 | 7054 | 34912072 |
Laryngeal pain | 12.19 | 11.27 | 15 | 37790 | 2749 | 34916377 |
Granulomatous rosacea | 12.11 | 11.27 | 5 | 37800 | 151 | 34918975 |
Parvovirus infection | 12.11 | 11.27 | 7 | 37798 | 446 | 34918680 |
Suprapubic pain | 12.08 | 11.27 | 7 | 37798 | 448 | 34918678 |
Lymphopenia | 12.05 | 11.27 | 42 | 37763 | 16293 | 34902833 |
Acute myocardial infarction | 12.03 | 11.27 | 25 | 37780 | 53694 | 34865432 |
Heart rate decreased | 12.00 | 11.27 | 10 | 37795 | 31735 | 34887391 |
Hepatitis C virus test | 11.95 | 11.27 | 4 | 37801 | 66 | 34919060 |
Febrile bone marrow aplasia | 11.91 | 11.27 | 27 | 37778 | 8182 | 34910944 |
Blood pressure increased | 11.82 | 11.27 | 52 | 37753 | 88050 | 34831076 |
Product prescribing error | 11.79 | 11.27 | 5 | 37800 | 22922 | 34896204 |
Sedation | 11.78 | 11.27 | 4 | 37801 | 21002 | 34898124 |
Autoimmune haemolytic anaemia | 11.76 | 11.27 | 19 | 37786 | 4477 | 34914649 |
Arthritis | 11.70 | 11.27 | 10 | 37795 | 31336 | 34887790 |
Blood chloride increased | 11.69 | 11.27 | 15 | 37790 | 2866 | 34916260 |
Granulomatosis with polyangiitis | 11.68 | 11.27 | 10 | 37795 | 1195 | 34917931 |
Biliary sepsis | 11.65 | 11.27 | 8 | 37797 | 689 | 34918437 |
Epidermal necrosis | 11.58 | 11.27 | 7 | 37798 | 484 | 34918642 |
Rectal prolapse | 11.57 | 11.27 | 7 | 37798 | 485 | 34918641 |
COVID-19 | 11.51 | 11.27 | 44 | 37761 | 77506 | 34841620 |
Heart transplant rejection | 11.50 | 11.27 | 10 | 37795 | 1221 | 34917905 |
Refusal of treatment by patient | 11.48 | 11.27 | 20 | 37785 | 5012 | 34914114 |
Accident | 11.43 | 11.27 | 20 | 37785 | 5027 | 34914099 |
Cytotoxic oedema | 11.40 | 11.27 | 5 | 37800 | 176 | 34918950 |
Complications of transplant surgery | 11.34 | 11.27 | 7 | 37798 | 503 | 34918623 |
Acute graft versus host disease in liver | 11.28 | 11.27 | 11 | 37794 | 1555 | 34917571 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 246.16 | 10.31 | 1009 | 69558 | 518395 | 79155426 |
Hyperkalaemia | 235.13 | 10.31 | 388 | 70179 | 114010 | 79559811 |
Drug ineffective | 177.54 | 10.31 | 439 | 70128 | 1080474 | 78593347 |
Pyrexia | 145.44 | 10.31 | 1062 | 69505 | 677647 | 78996174 |
Pre-engraftment immune reaction | 141.25 | 10.31 | 37 | 70530 | 304 | 79673517 |
Off label use | 139.87 | 10.31 | 380 | 70187 | 906835 | 78766986 |
Completed suicide | 136.52 | 10.31 | 26 | 70541 | 245741 | 79428080 |
Stevens-Johnson syndrome | 130.38 | 10.31 | 167 | 70400 | 38999 | 79634822 |
Pancytopenia | 113.87 | 10.31 | 364 | 70203 | 165381 | 79508440 |
Product dose omission issue | 111.26 | 10.31 | 40 | 70527 | 247497 | 79426324 |
Death | 107.46 | 10.31 | 212 | 70355 | 566302 | 79107519 |
Encephalitis viral | 106.64 | 10.31 | 50 | 70517 | 2529 | 79671292 |
Swelling face | 103.55 | 10.31 | 208 | 70359 | 71004 | 79602817 |
Drug abuse | 97.46 | 10.31 | 14 | 70553 | 162677 | 79511144 |
Blood creatinine increased | 93.58 | 10.31 | 326 | 70241 | 154731 | 79519090 |
Cytomegalovirus infection | 88.00 | 10.31 | 145 | 70422 | 42499 | 79631322 |
Liver function test abnormal | 87.45 | 10.31 | 183 | 70384 | 64292 | 79609529 |
Soft tissue disorder | 86.47 | 10.31 | 48 | 70519 | 3467 | 79670354 |
Leukopenia | 79.18 | 10.31 | 255 | 70312 | 116258 | 79557563 |
Injection site pain | 78.17 | 10.31 | 11 | 70556 | 129827 | 79543994 |
Human herpesvirus 6 infection | 77.19 | 10.31 | 52 | 70515 | 5318 | 79668503 |
Immune reconstitution inflammatory syndrome | 76.84 | 10.31 | 77 | 70490 | 13764 | 79660057 |
Kidney transplant rejection | 76.10 | 10.31 | 67 | 70500 | 10179 | 79663642 |
Fatigue | 72.47 | 10.31 | 504 | 70063 | 929223 | 78744598 |
Transplant rejection | 69.65 | 10.31 | 86 | 70481 | 19351 | 79654470 |
Product use issue | 67.62 | 10.31 | 52 | 70515 | 209770 | 79464051 |
Hyponatraemia | 65.37 | 10.31 | 321 | 70246 | 177527 | 79496294 |
Drug reaction with eosinophilia and systemic symptoms | 61.45 | 10.31 | 159 | 70408 | 64085 | 79609736 |
Inappropriate schedule of product administration | 61.02 | 10.31 | 21 | 70546 | 133607 | 79540214 |
Pneumonia viral | 60.37 | 10.31 | 56 | 70511 | 9102 | 79664719 |
Neutropenia | 60.03 | 10.31 | 448 | 70119 | 287262 | 79386559 |
Allergy to chemicals | 59.85 | 10.31 | 34 | 70533 | 2568 | 79671253 |
Thrombocytopenia | 59.34 | 10.31 | 420 | 70147 | 264839 | 79408982 |
Rash maculo-papular | 58.03 | 10.31 | 143 | 70424 | 55935 | 79617886 |
Toxicity to various agents | 57.14 | 10.31 | 187 | 70380 | 421353 | 79252468 |
Intentional overdose | 57.14 | 10.31 | 12 | 70555 | 105948 | 79567873 |
Tenosynovitis stenosans | 57.10 | 10.31 | 35 | 70532 | 3043 | 79670778 |
International normalised ratio increased | 54.47 | 10.31 | 182 | 70385 | 84539 | 79589282 |
Synovial fluid analysis | 52.05 | 10.31 | 30 | 70537 | 2329 | 79671492 |
Fall | 51.57 | 10.31 | 239 | 70328 | 487390 | 79186431 |
Scleritis | 50.54 | 10.31 | 37 | 70530 | 4319 | 79669502 |
Haemodialysis | 49.08 | 10.31 | 70 | 70497 | 18098 | 79655723 |
Lip swelling | 48.49 | 10.31 | 110 | 70457 | 40801 | 79633020 |
Renal failure | 47.75 | 10.31 | 323 | 70244 | 200645 | 79473176 |
Wrong technique in product usage process | 47.55 | 10.31 | 5 | 70562 | 73870 | 79599951 |
Nasopharyngitis | 47.16 | 10.31 | 96 | 70471 | 253785 | 79420036 |
Psoriasis | 46.58 | 10.31 | 11 | 70556 | 89576 | 79584245 |
Fear of eating | 46.39 | 10.31 | 17 | 70550 | 456 | 79673365 |
Renal tubular necrosis | 46.18 | 10.31 | 81 | 70486 | 24958 | 79648863 |
Rash | 45.40 | 10.31 | 741 | 69826 | 577617 | 79096204 |
Blood pressure increased | 44.51 | 10.31 | 74 | 70493 | 211286 | 79462535 |
Agranulocytosis | 42.60 | 10.31 | 111 | 70456 | 44919 | 79628902 |
Toxic epidermal necrolysis | 42.28 | 10.31 | 110 | 70457 | 44471 | 79629350 |
Platelet count decreased | 41.63 | 10.31 | 305 | 70262 | 194359 | 79479462 |
Intentional product use issue | 41.47 | 10.31 | 44 | 70523 | 152068 | 79521753 |
Pneumocystis jirovecii pneumonia | 41.45 | 10.31 | 90 | 70477 | 32418 | 79641403 |
Genital ulceration | 41.43 | 10.31 | 20 | 70547 | 1080 | 79672741 |
Photophobia | 41.27 | 10.31 | 69 | 70498 | 20459 | 79653362 |
Ureteric obstruction | 40.72 | 10.31 | 27 | 70540 | 2689 | 79671132 |
Intentional product misuse | 40.04 | 10.31 | 17 | 70550 | 95148 | 79578673 |
Conjunctivitis | 39.64 | 10.31 | 77 | 70490 | 25638 | 79648183 |
Urosepsis | 39.22 | 10.31 | 78 | 70489 | 26417 | 79647404 |
Weight increased | 38.98 | 10.31 | 121 | 70446 | 277265 | 79396556 |
Ejection fraction decreased | 38.81 | 10.31 | 91 | 70476 | 34486 | 79639335 |
Tubulointerstitial nephritis | 37.98 | 10.31 | 96 | 70471 | 38139 | 79635682 |
Mouth swelling | 37.96 | 10.31 | 36 | 70531 | 6015 | 79667806 |
Tenderness | 37.93 | 10.31 | 72 | 70495 | 23570 | 79650251 |
Alopecia | 37.65 | 10.31 | 94 | 70473 | 231261 | 79442560 |
Haemorrhoids | 37.54 | 10.31 | 81 | 70486 | 29047 | 79644774 |
Genital pain | 37.46 | 10.31 | 17 | 70550 | 797 | 79673024 |
Blood urea increased | 37.02 | 10.31 | 111 | 70456 | 48679 | 79625142 |
Pleuritic pain | 36.50 | 10.31 | 45 | 70522 | 10107 | 79663714 |
Psoriatic arthropathy | 36.05 | 10.31 | 12 | 70555 | 77987 | 79595834 |
Hepatitis | 35.18 | 10.31 | 119 | 70448 | 55608 | 79618213 |
Suicide attempt | 34.60 | 10.31 | 15 | 70552 | 82917 | 79590904 |
Hypophagia | 34.22 | 10.31 | 103 | 70464 | 45264 | 79628557 |
Abdominal discomfort | 34.08 | 10.31 | 111 | 70456 | 250616 | 79423205 |
Confusional state | 33.88 | 10.31 | 430 | 70137 | 317567 | 79356254 |
Anal inflammation | 33.74 | 10.31 | 19 | 70548 | 1411 | 79672410 |
Swollen tongue | 33.39 | 10.31 | 98 | 70469 | 42472 | 79631349 |
Nasal congestion | 33.30 | 10.31 | 13 | 70554 | 76539 | 79597282 |
Dialysis | 33.11 | 10.31 | 59 | 70508 | 18403 | 79655418 |
Angioedema | 32.89 | 10.31 | 144 | 70423 | 75891 | 79597930 |
Injection site erythema | 32.85 | 10.31 | 14 | 70553 | 78183 | 79595638 |
Crepitations | 32.21 | 10.31 | 42 | 70525 | 9975 | 79663846 |
Respiratory tract infection bacterial | 31.99 | 10.31 | 21 | 70546 | 2056 | 79671765 |
Blood pressure systolic increased | 31.50 | 10.31 | 10 | 70557 | 66976 | 79606845 |
Deafness transitory | 31.28 | 10.31 | 16 | 70551 | 979 | 79672842 |
Rash pruritic | 30.49 | 10.31 | 135 | 70432 | 71494 | 79602327 |
Jaundice | 30.29 | 10.31 | 110 | 70457 | 53239 | 79620582 |
Rash erythematous | 30.20 | 10.31 | 116 | 70451 | 57653 | 79616168 |
Deep vein thrombosis | 29.69 | 10.31 | 196 | 70371 | 120723 | 79553098 |
Blood lactate dehydrogenase increased | 29.61 | 10.31 | 89 | 70478 | 39081 | 79634740 |
Influenza | 29.54 | 10.31 | 43 | 70524 | 129563 | 79544258 |
Bone marrow failure | 29.54 | 10.31 | 106 | 70461 | 51001 | 79622820 |
Cushingoid | 29.09 | 10.31 | 39 | 70528 | 9513 | 79664308 |
Deformity | 28.92 | 10.31 | 39 | 70528 | 9566 | 79664255 |
Superinfection | 28.56 | 10.31 | 28 | 70539 | 4874 | 79668947 |
Blood potassium increased | 28.55 | 10.31 | 73 | 70494 | 29202 | 79644619 |
Cellulitis enterococcal | 28.09 | 10.31 | 7 | 70560 | 46 | 79673775 |
Atelectasis | 27.97 | 10.31 | 77 | 70490 | 32180 | 79641641 |
Meningoencephalitis herpetic | 27.97 | 10.31 | 19 | 70548 | 1970 | 79671851 |
Blood alkaline phosphatase increased | 27.86 | 10.31 | 121 | 70446 | 63543 | 79610278 |
Liver transplant rejection | 27.71 | 10.31 | 23 | 70544 | 3225 | 79670596 |
Proctalgia | 27.70 | 10.31 | 39 | 70528 | 9962 | 79663859 |
Oral pain | 27.67 | 10.31 | 76 | 70491 | 31722 | 79642099 |
Intestinal intraepithelial lymphocytes increased | 27.47 | 10.31 | 9 | 70558 | 171 | 79673650 |
Asthma | 26.88 | 10.31 | 49 | 70518 | 135046 | 79538775 |
Hepatic cytolysis | 26.78 | 10.31 | 68 | 70499 | 27083 | 79646738 |
Alanine aminotransferase increased | 26.76 | 10.31 | 240 | 70327 | 162330 | 79511491 |
Clostridial infection | 26.71 | 10.31 | 29 | 70538 | 5685 | 79668136 |
Blood culture positive | 26.57 | 10.31 | 35 | 70532 | 8394 | 79665427 |
Haemoglobin decreased | 26.53 | 10.31 | 307 | 70260 | 221812 | 79452009 |
SARS-CoV-2 test negative | 26.48 | 10.31 | 16 | 70551 | 1355 | 79672466 |
Bronchopulmonary aspergillosis | 26.48 | 10.31 | 60 | 70507 | 22234 | 79651587 |
Documented hypersensitivity to administered product | 26.26 | 10.31 | 14 | 70553 | 933 | 79672888 |
Vulvovaginal candidiasis | 26.15 | 10.31 | 20 | 70547 | 2494 | 79671327 |
Hospitalisation | 25.97 | 10.31 | 27 | 70540 | 94209 | 79579612 |
Maternal exposure during pregnancy | 25.87 | 10.31 | 51 | 70516 | 136487 | 79537334 |
Complications of transplanted kidney | 25.81 | 10.31 | 30 | 70537 | 6336 | 79667485 |
Plasma cell myeloma | 25.47 | 10.31 | 104 | 70463 | 53155 | 79620666 |
Mental status changes | 25.39 | 10.31 | 122 | 70445 | 66837 | 79606984 |
Arthralgia | 25.34 | 10.31 | 355 | 70212 | 571448 | 79102373 |
Liver transplant | 25.28 | 10.31 | 25 | 70542 | 4398 | 79669423 |
Febrile bone marrow aplasia | 25.16 | 10.31 | 43 | 70524 | 12977 | 79660844 |
Bacterial test positive | 25.15 | 10.31 | 32 | 70535 | 7417 | 79666404 |
Vaginal discharge | 25.11 | 10.31 | 32 | 70535 | 7431 | 79666390 |
Systemic lupus erythematosus | 24.95 | 10.31 | 43 | 70524 | 121106 | 79552715 |
Liver function test increased | 24.82 | 10.31 | 3 | 70564 | 39770 | 79634051 |
Infusion related reaction | 24.79 | 10.31 | 112 | 70455 | 230125 | 79443696 |
Aspartate aminotransferase increased | 24.54 | 10.31 | 208 | 70359 | 138433 | 79535388 |
Injection site pruritus | 24.48 | 10.31 | 4 | 70563 | 42279 | 79631542 |
Loss of personal independence in daily activities | 24.41 | 10.31 | 33 | 70534 | 102547 | 79571274 |
Aspergillus infection | 24.37 | 10.31 | 53 | 70514 | 19108 | 79654713 |
Fluid retention | 24.18 | 10.31 | 16 | 70551 | 69793 | 79604028 |
COVID-19 | 24.16 | 10.31 | 66 | 70501 | 157608 | 79516213 |
Dermatitis exfoliative | 23.94 | 10.31 | 38 | 70529 | 10791 | 79663030 |
Blood bilirubin increased | 23.91 | 10.31 | 119 | 70448 | 66113 | 79607708 |
Hepatosplenomegaly | 23.61 | 10.31 | 28 | 70539 | 6041 | 79667780 |
Pseudomonas infection | 23.44 | 10.31 | 55 | 70512 | 20848 | 79652973 |
Culture urine positive | 23.39 | 10.31 | 24 | 70543 | 4411 | 79669410 |
Serum sickness | 23.36 | 10.31 | 22 | 70545 | 3644 | 79670177 |
Rash morbilliform | 23.31 | 10.31 | 28 | 70539 | 6122 | 79667699 |
Synovial cyst | 23.19 | 10.31 | 36 | 70531 | 10029 | 79663792 |
Pulmonary embolism | 23.13 | 10.31 | 243 | 70324 | 171411 | 79502410 |
Oral candidiasis | 23.04 | 10.31 | 68 | 70499 | 29560 | 79644261 |
Cryptitis | 23.04 | 10.31 | 9 | 70558 | 289 | 79673532 |
Feeling jittery | 22.98 | 10.31 | 41 | 70526 | 12800 | 79661021 |
Pregnancy with injectable contraceptive | 22.78 | 10.31 | 7 | 70560 | 107 | 79673714 |
Injection site reaction | 22.71 | 10.31 | 10 | 70557 | 54775 | 79619046 |
Pain | 22.41 | 10.31 | 464 | 70103 | 703338 | 78970483 |
Arthropathy | 22.30 | 10.31 | 81 | 70486 | 177030 | 79496791 |
Injection site swelling | 22.22 | 10.31 | 7 | 70560 | 47125 | 79626696 |
Toxic skin eruption | 22.16 | 10.31 | 56 | 70511 | 22237 | 79651584 |
Renal tubular disorder | 22.12 | 10.31 | 28 | 70539 | 6458 | 79667363 |
Overdose | 22.06 | 10.31 | 86 | 70481 | 184120 | 79489701 |
Vomiting | 21.85 | 10.31 | 756 | 69811 | 665072 | 79008749 |
Product use in unapproved indication | 21.77 | 10.31 | 131 | 70436 | 250228 | 79423593 |
Microvillous inclusion disease | 21.75 | 10.31 | 8 | 70559 | 217 | 79673604 |
Red blood cell sedimentation rate increased | 21.35 | 10.31 | 7 | 70560 | 45935 | 79627886 |
Apoptosis | 21.25 | 10.31 | 10 | 70557 | 510 | 79673311 |
Lung infiltration | 21.18 | 10.31 | 56 | 70511 | 22856 | 79650965 |
Excessive eye blinking | 20.99 | 10.31 | 15 | 70552 | 1686 | 79672135 |
Blood sodium decreased | 20.97 | 10.31 | 71 | 70496 | 33184 | 79640637 |
Therapeutic response decreased | 20.97 | 10.31 | 17 | 70550 | 66836 | 79606985 |
Graft versus host disease | 20.77 | 10.31 | 43 | 70524 | 14983 | 79658838 |
Meningitis aseptic | 20.66 | 10.31 | 28 | 70539 | 6900 | 79666921 |
Blood antidiuretic hormone increased | 20.64 | 10.31 | 6 | 70561 | 75 | 79673746 |
White blood cell count decreased | 20.62 | 10.31 | 256 | 70311 | 188032 | 79485789 |
Respiratory tract infection viral | 20.59 | 10.31 | 22 | 70545 | 4237 | 79669584 |
Hepatomegaly | 20.45 | 10.31 | 49 | 70518 | 18825 | 79654996 |
Probiotic therapy | 20.45 | 10.31 | 7 | 70560 | 153 | 79673668 |
Rheumatoid arthritis | 20.35 | 10.31 | 105 | 70462 | 208365 | 79465456 |
Leukaemia recurrent | 20.32 | 10.31 | 18 | 70549 | 2756 | 79671065 |
Viral test positive | 20.14 | 10.31 | 9 | 70558 | 407 | 79673414 |
Fibromyalgia | 20.06 | 10.31 | 111 | 70456 | 64229 | 79609592 |
Parkinsonian rest tremor | 20.02 | 10.31 | 8 | 70559 | 273 | 79673548 |
Neutropenic sepsis | 19.99 | 10.31 | 61 | 70506 | 27003 | 79646818 |
Flank pain | 19.89 | 10.31 | 50 | 70517 | 19794 | 79654027 |
Renal papillary necrosis | 19.85 | 10.31 | 9 | 70558 | 421 | 79673400 |
Urinary tract infection | 19.74 | 10.31 | 347 | 70220 | 274165 | 79399656 |
Rhinorrhoea | 19.63 | 10.31 | 23 | 70544 | 76051 | 79597770 |
Stress | 19.56 | 10.31 | 25 | 70542 | 79587 | 79594234 |
Aplasia pure red cell | 19.51 | 10.31 | 29 | 70538 | 7781 | 79666040 |
Liver disorder | 19.38 | 10.31 | 120 | 70447 | 72297 | 79601524 |
Acquired immunodeficiency syndrome | 19.33 | 10.31 | 8 | 70559 | 299 | 79673522 |
Antinuclear antibody positive | 19.28 | 10.31 | 29 | 70538 | 7861 | 79665960 |
Cataract | 19.23 | 10.31 | 16 | 70551 | 62104 | 79611717 |
Palmar erythema | 19.19 | 10.31 | 15 | 70552 | 1932 | 79671889 |
Refusal of treatment by patient | 19.12 | 10.31 | 31 | 70536 | 8960 | 79664861 |
Trimethylaminuria | 19.06 | 10.31 | 7 | 70560 | 189 | 79673632 |
Body mass index decreased | 18.95 | 10.31 | 10 | 70557 | 653 | 79673168 |
Cardiogenic shock | 18.43 | 10.31 | 7 | 70560 | 41907 | 79631914 |
Cholestasis | 18.37 | 10.31 | 93 | 70474 | 52016 | 79621805 |
Thrombotic microangiopathy | 18.34 | 10.31 | 49 | 70518 | 20120 | 79653701 |
Gastrointestinal pain | 18.33 | 10.31 | 32 | 70535 | 9823 | 79663998 |
Cytomegalovirus test | 18.21 | 10.31 | 5 | 70562 | 50 | 79673771 |
Chronic lymphocytic leukaemia | 18.19 | 10.31 | 22 | 70545 | 4844 | 79668977 |
Hepatitis fulminant | 18.19 | 10.31 | 27 | 70540 | 7235 | 79666586 |
Pulmonary toxicity | 17.90 | 10.31 | 37 | 70530 | 12877 | 79660944 |
Chronic obstructive pulmonary disease | 17.88 | 10.31 | 30 | 70537 | 85389 | 79588432 |
Clostridium difficile infection | 17.82 | 10.31 | 80 | 70487 | 42605 | 79631216 |
Colour blindness acquired | 17.80 | 10.31 | 6 | 70561 | 125 | 79673696 |
Chronic sinusitis | 17.68 | 10.31 | 37 | 70530 | 12989 | 79660832 |
Clostridium test positive | 17.63 | 10.31 | 25 | 70542 | 6429 | 79667392 |
Ocular hyperaemia | 17.59 | 10.31 | 60 | 70507 | 28146 | 79645675 |
Seizure | 17.46 | 10.31 | 249 | 70318 | 188585 | 79485236 |
Foaming at mouth | 17.37 | 10.31 | 14 | 70553 | 1883 | 79671938 |
Enterococcal infection | 17.34 | 10.31 | 41 | 70526 | 15619 | 79658202 |
Erythema multiforme | 17.19 | 10.31 | 44 | 70523 | 17607 | 79656214 |
Treatment failure | 17.13 | 10.31 | 85 | 70482 | 170401 | 79503420 |
Biliary sepsis | 17.12 | 10.31 | 13 | 70554 | 1604 | 79672217 |
Mucosal inflammation | 17.05 | 10.31 | 120 | 70447 | 75460 | 79598361 |
Paraesthesia oral | 16.90 | 10.31 | 48 | 70519 | 20423 | 79653398 |
Culture stool positive | 16.71 | 10.31 | 9 | 70558 | 612 | 79673209 |
Lymphocele | 16.67 | 10.31 | 13 | 70554 | 1668 | 79672153 |
Autoimmune haemolytic anaemia | 16.62 | 10.31 | 28 | 70539 | 8352 | 79665469 |
HIV wasting syndrome | 16.61 | 10.31 | 5 | 70562 | 71 | 79673750 |
Blood pressure fluctuation | 16.59 | 10.31 | 21 | 70546 | 67124 | 79606697 |
Angiodermatitis | 16.42 | 10.31 | 5 | 70562 | 74 | 79673747 |
Macular degeneration | 16.41 | 10.31 | 33 | 70534 | 11263 | 79662558 |
HIV infection | 16.41 | 10.31 | 11 | 70556 | 1116 | 79672705 |
Renal tubular acidosis | 16.30 | 10.31 | 18 | 70549 | 3596 | 79670225 |
Osteonecrosis of jaw | 16.24 | 10.31 | 9 | 70558 | 43217 | 79630604 |
Biopsy liver abnormal | 16.20 | 10.31 | 8 | 70559 | 454 | 79673367 |
Antinuclear antibody | 16.12 | 10.31 | 8 | 70559 | 459 | 79673362 |
Sinusitis | 16.11 | 10.31 | 104 | 70463 | 195397 | 79478424 |
Rash macular | 15.91 | 10.31 | 59 | 70508 | 28840 | 79644981 |
Dehydration | 15.84 | 10.31 | 308 | 70259 | 247879 | 79425942 |
Pemphigus | 15.77 | 10.31 | 41 | 70526 | 99541 | 79574280 |
Orbital haemorrhage | 15.71 | 10.31 | 4 | 70563 | 29 | 79673792 |
Cholecystitis chronic | 15.68 | 10.31 | 30 | 70537 | 9876 | 79663945 |
Inappropriate antidiuretic hormone secretion | 15.57 | 10.31 | 55 | 70512 | 26258 | 79647563 |
Memory impairment | 15.49 | 10.31 | 49 | 70518 | 111685 | 79562136 |
Effusion | 15.49 | 10.31 | 14 | 70553 | 2200 | 79671621 |
Rectal haemorrhage | 15.41 | 10.31 | 118 | 70449 | 76182 | 79597639 |
Eye pain | 15.37 | 10.31 | 70 | 70497 | 37508 | 79636313 |
Abdominal pain | 15.27 | 10.31 | 452 | 70115 | 389117 | 79284704 |
Blindness cortical | 15.25 | 10.31 | 10 | 70557 | 977 | 79672844 |
Purpura senile | 15.16 | 10.31 | 8 | 70559 | 522 | 79673299 |
Myocardial infarction | 15.15 | 10.31 | 98 | 70469 | 184031 | 79489790 |
Vena cava injury | 15.10 | 10.31 | 7 | 70560 | 345 | 79673476 |
Tarsal tunnel syndrome | 15.08 | 10.31 | 8 | 70559 | 528 | 79673293 |
Complications of transplant surgery | 15.05 | 10.31 | 9 | 70558 | 748 | 79673073 |
Chemotherapeutic drug level increased | 15.00 | 10.31 | 7 | 70560 | 350 | 79673471 |
Granulomatous rosacea | 14.87 | 10.31 | 6 | 70561 | 210 | 79673611 |
Erythema infectiosum | 14.84 | 10.31 | 6 | 70561 | 211 | 79673610 |
Bone density decreased | 14.84 | 10.31 | 35 | 70532 | 13312 | 79660509 |
Blood bilirubin unconjugated increased | 14.80 | 10.31 | 10 | 70557 | 1027 | 79672794 |
Synovial disorder | 14.79 | 10.31 | 13 | 70554 | 1970 | 79671851 |
Drug interaction | 14.75 | 10.31 | 476 | 70091 | 414707 | 79259114 |
Cystitis noninfective | 14.69 | 10.31 | 11 | 70556 | 1329 | 79672492 |
Drug dependence | 14.59 | 10.31 | 9 | 70558 | 40760 | 79633061 |
Pain in extremity | 14.50 | 10.31 | 231 | 70336 | 364307 | 79309514 |
Rheumatoid factor positive | 14.49 | 10.31 | 19 | 70548 | 59820 | 79614001 |
Cardiac failure congestive | 14.30 | 10.31 | 71 | 70496 | 142331 | 79531490 |
Pericarditis | 14.25 | 10.31 | 46 | 70521 | 104190 | 79569631 |
Accidental exposure to product | 14.16 | 10.31 | 5 | 70562 | 31317 | 79642504 |
Neuropathy peripheral | 14.15 | 10.31 | 189 | 70378 | 141116 | 79532705 |
Unevaluable event | 14.13 | 10.31 | 17 | 70550 | 55568 | 79618253 |
Lymphopenia | 14.08 | 10.31 | 59 | 70508 | 30498 | 79643323 |
Hepatitis cholestatic | 13.98 | 10.31 | 35 | 70532 | 13817 | 79660004 |
Myositis | 13.97 | 10.31 | 43 | 70524 | 19125 | 79654696 |
Glossodynia | 13.85 | 10.31 | 46 | 70521 | 103291 | 79570530 |
Therapy cessation | 13.85 | 10.31 | 8 | 70559 | 37554 | 79636267 |
Device expulsion | 13.79 | 10.31 | 3 | 70564 | 25858 | 79647963 |
Gastric disorder | 13.76 | 10.31 | 8 | 70559 | 37425 | 79636396 |
Hepatic failure | 13.70 | 10.31 | 97 | 70470 | 61115 | 79612706 |
Vaginal flatulence | 13.70 | 10.31 | 14 | 70553 | 2561 | 79671260 |
Wound evisceration | 13.68 | 10.31 | 5 | 70562 | 133 | 79673688 |
SARS-CoV-2 antibody test positive | 13.63 | 10.31 | 7 | 70560 | 432 | 79673389 |
Limb discomfort | 13.61 | 10.31 | 6 | 70561 | 32844 | 79640977 |
Soft tissue swelling | 13.58 | 10.31 | 11 | 70556 | 1490 | 79672331 |
Malaise | 13.57 | 10.31 | 546 | 70021 | 489323 | 79184498 |
Purpura | 13.49 | 10.31 | 43 | 70524 | 19484 | 79654337 |
Pseudomembranous colitis | 13.49 | 10.31 | 20 | 70547 | 5354 | 79668467 |
Gait disturbance | 13.48 | 10.31 | 118 | 70449 | 207388 | 79466433 |
Proctitis | 13.44 | 10.31 | 22 | 70545 | 6410 | 79667411 |
Lung transplant rejection | 13.39 | 10.31 | 11 | 70556 | 1520 | 79672301 |
Vaginal ulceration | 13.39 | 10.31 | 6 | 70561 | 273 | 79673548 |
Tenosynovitis | 13.36 | 10.31 | 37 | 70530 | 15517 | 79658304 |
Cytomegalovirus test positive | 13.33 | 10.31 | 21 | 70546 | 5926 | 79667895 |
Intentional self-injury | 13.30 | 10.31 | 6 | 70561 | 32413 | 79641408 |
Autonomic neuropathy | 13.29 | 10.31 | 12 | 70555 | 1883 | 79671938 |
Osteoporosis | 13.29 | 10.31 | 17 | 70550 | 54095 | 79619726 |
Lymphocytic infiltration | 13.26 | 10.31 | 11 | 70556 | 1542 | 79672279 |
Pneumonia cytomegaloviral | 13.21 | 10.31 | 19 | 70548 | 4950 | 79668871 |
Bacterial sepsis | 13.19 | 10.31 | 25 | 70542 | 8173 | 79665648 |
Muscle twitching | 13.16 | 10.31 | 50 | 70517 | 24714 | 79649107 |
Hepatic enzyme increased | 13.15 | 10.31 | 101 | 70466 | 182509 | 79491312 |
Abdominal wall haemorrhage | 13.15 | 10.31 | 8 | 70559 | 686 | 79673135 |
Potentiating drug interaction | 13.10 | 10.31 | 26 | 70541 | 8793 | 79665028 |
Enterovirus infection | 13.01 | 10.31 | 12 | 70555 | 1935 | 79671886 |
Discomfort | 12.98 | 10.31 | 62 | 70505 | 125555 | 79548266 |
Condition aggravated | 12.94 | 10.31 | 341 | 70226 | 500783 | 79173038 |
Acne | 12.89 | 10.31 | 4 | 70563 | 27186 | 79646635 |
Cushing's syndrome | 12.80 | 10.31 | 9 | 70558 | 986 | 79672835 |
Body temperature increased | 12.77 | 10.31 | 75 | 70492 | 44345 | 79629476 |
Joint effusion | 12.75 | 10.31 | 40 | 70527 | 17974 | 79655847 |
Adverse event | 12.74 | 10.31 | 21 | 70546 | 60193 | 79613628 |
Heart rate decreased | 12.69 | 10.31 | 27 | 70540 | 70289 | 79603532 |
Eosinophilia | 12.68 | 10.31 | 76 | 70491 | 45269 | 79628552 |
Dermatitis allergic | 12.59 | 10.31 | 40 | 70527 | 18090 | 79655731 |
Febrile neutropenia | 12.55 | 10.31 | 280 | 70287 | 230719 | 79443102 |
Genital burning sensation | 12.46 | 10.31 | 6 | 70561 | 322 | 79673499 |
Tumour lysis syndrome | 12.45 | 10.31 | 48 | 70519 | 23891 | 79649930 |
Prurigo | 12.32 | 10.31 | 10 | 70557 | 1359 | 79672462 |
Osteoarthritis | 12.31 | 10.31 | 38 | 70529 | 87271 | 79586550 |
Infection | 12.21 | 10.31 | 290 | 70277 | 241422 | 79432399 |
Wound | 12.20 | 10.31 | 57 | 70510 | 116122 | 79557699 |
Petechiae | 12.18 | 10.31 | 43 | 70524 | 20522 | 79653299 |
Hepatitis C virus test | 12.16 | 10.31 | 4 | 70563 | 77 | 79673744 |
Surgery | 12.05 | 10.31 | 7 | 70560 | 32759 | 79641062 |
Flatulence | 12.04 | 10.31 | 12 | 70555 | 42712 | 79631109 |
Sedation | 12.04 | 10.31 | 17 | 70550 | 51878 | 79621943 |
Renal transplant | 12.04 | 10.31 | 13 | 70554 | 2534 | 79671287 |
Limb reduction defect | 11.92 | 10.31 | 4 | 70563 | 82 | 79673739 |
Lung neoplasm | 11.92 | 10.31 | 22 | 70545 | 7047 | 79666774 |
Contraindicated product administered | 11.89 | 10.31 | 86 | 70481 | 157452 | 79516369 |
Human herpesvirus 6 infection reactivation | 11.86 | 10.31 | 7 | 70560 | 568 | 79673253 |
Anti-cyclic citrullinated peptide antibody positive | 11.85 | 10.31 | 36 | 70531 | 83107 | 79590714 |
Tumour flare | 11.83 | 10.31 | 9 | 70558 | 1114 | 79672707 |
Culture positive | 11.80 | 10.31 | 9 | 70558 | 1117 | 79672704 |
Perinephric collection | 11.79 | 10.31 | 6 | 70561 | 363 | 79673458 |
Sleep apnoea syndrome | 11.79 | 10.31 | 9 | 70558 | 36469 | 79637352 |
Staphylococcal infection | 11.69 | 10.31 | 90 | 70477 | 58205 | 79615616 |
Acute graft versus host disease | 11.67 | 10.31 | 27 | 70540 | 10140 | 79663681 |
Hydronephrosis | 11.66 | 10.31 | 38 | 70529 | 17416 | 79656405 |
Areflexia | 11.66 | 10.31 | 19 | 70548 | 5515 | 79668306 |
Suicidal ideation | 11.65 | 10.31 | 32 | 70535 | 76308 | 79597513 |
Idiopathic pneumonia syndrome | 11.63 | 10.31 | 7 | 70560 | 589 | 79673232 |
Acute graft versus host disease in intestine | 11.55 | 10.31 | 16 | 70551 | 4025 | 79669796 |
Cardio-respiratory arrest | 11.54 | 10.31 | 53 | 70514 | 108457 | 79565364 |
Cholelithiasis | 11.52 | 10.31 | 83 | 70484 | 52581 | 79621240 |
Immunosuppressant drug level increased | 11.51 | 10.31 | 25 | 70542 | 9002 | 79664819 |
Product quality issue | 11.45 | 10.31 | 8 | 70559 | 33932 | 79639889 |
Haematocrit decreased | 11.38 | 10.31 | 93 | 70474 | 61219 | 79612602 |
Altered visual depth perception | 11.38 | 10.31 | 6 | 70561 | 391 | 79673430 |
Hypovolaemia | 11.36 | 10.31 | 38 | 70529 | 17653 | 79656168 |
Limb injury | 11.31 | 10.31 | 6 | 70561 | 29522 | 79644299 |
Escherichia test positive | 11.30 | 10.31 | 14 | 70553 | 3161 | 79670660 |
Blood chloride increased | 11.27 | 10.31 | 18 | 70549 | 5138 | 79668683 |
Syncope | 11.23 | 10.31 | 103 | 70464 | 179346 | 79494475 |
Lip ulceration | 11.22 | 10.31 | 12 | 70555 | 2313 | 79671508 |
Drug hypersensitivity | 11.21 | 10.31 | 345 | 70222 | 298571 | 79375250 |
Haemolytic anaemia | 11.20 | 10.31 | 38 | 70529 | 17782 | 79656039 |
Loss of consciousness | 11.13 | 10.31 | 95 | 70472 | 167848 | 79505973 |
Glioblastoma multiforme | 11.11 | 10.31 | 9 | 70558 | 1219 | 79672602 |
Prostatitis | 11.07 | 10.31 | 16 | 70551 | 4186 | 79669635 |
Cerebral toxoplasmosis | 11.06 | 10.31 | 12 | 70555 | 2350 | 79671471 |
Motion sickness | 11.06 | 10.31 | 8 | 70559 | 917 | 79672904 |
Multiple sclerosis relapse | 11.04 | 10.31 | 15 | 70552 | 46518 | 79627303 |
Migraine | 11.02 | 10.31 | 40 | 70527 | 87453 | 79586368 |
No adverse event | 11.00 | 10.31 | 10 | 70557 | 37182 | 79636639 |
Pneumonia fungal | 10.98 | 10.31 | 28 | 70539 | 11182 | 79662639 |
Nail infection | 10.91 | 10.31 | 12 | 70555 | 2387 | 79671434 |
Food poisoning | 10.91 | 10.31 | 17 | 70550 | 4752 | 79669069 |
Parkinsonism hyperpyrexia syndrome | 10.85 | 10.31 | 5 | 70562 | 243 | 79673578 |
Hot flush | 10.83 | 10.31 | 20 | 70547 | 54857 | 79618964 |
Hepatitis B antibody positive | 10.82 | 10.31 | 4 | 70563 | 110 | 79673711 |
Hepatitis A antibody positive | 10.79 | 10.31 | 4 | 70563 | 111 | 79673710 |
Apraxia | 10.78 | 10.31 | 13 | 70554 | 2854 | 79670967 |
Pustule | 10.75 | 10.31 | 11 | 70556 | 2014 | 79671807 |
Impaired work ability | 10.68 | 10.31 | 40 | 70527 | 19641 | 79654180 |
Renal cyst haemorrhage | 10.67 | 10.31 | 7 | 70560 | 685 | 79673136 |
Herpes simplex viraemia | 10.66 | 10.31 | 6 | 70561 | 445 | 79673376 |
Candida infection | 10.65 | 10.31 | 64 | 70503 | 38150 | 79635671 |
Drug intolerance | 10.62 | 10.31 | 167 | 70400 | 263952 | 79409869 |
Chills | 10.61 | 10.31 | 200 | 70367 | 160034 | 79513787 |
Acute febrile neutrophilic dermatosis | 10.58 | 10.31 | 15 | 70552 | 3857 | 79669964 |
Suprapubic pain | 10.56 | 10.31 | 8 | 70559 | 984 | 79672837 |
Tooth disorder | 10.54 | 10.31 | 5 | 70562 | 26228 | 79647593 |
Pulmonary arterial hypertension | 10.52 | 10.31 | 6 | 70561 | 28360 | 79645461 |
Bronchitis | 10.50 | 10.31 | 70 | 70497 | 130574 | 79543247 |
Herpes simplex | 10.47 | 10.31 | 29 | 70538 | 12158 | 79661663 |
Erosive duodenitis | 10.35 | 10.31 | 11 | 70556 | 2106 | 79671715 |
Proteus infection | 10.34 | 10.31 | 11 | 70556 | 2107 | 79671714 |
None
Source | Code | Description |
---|---|---|
ATC | J01EA01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Trimethoprim and derivatives |
ATC | J01EE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J01EE02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J01EE03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J01EE04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J01EE05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J01EE07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J04AM08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
FDA MoA | N0000000191 | Dihydrofolate Reductase Inhibitors |
FDA EPC | N0000175489 | Dihydrofolate Reductase Inhibitor Antibacterial |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000892 | Anti-Infective Agents, Urinary |
MeSH PA | D000962 | Antimalarials |
MeSH PA | D000977 | Antiparasitic Agents |
MeSH PA | D000981 | Antiprotozoal Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065687 | Cytochrome P-450 CYP2C8 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D005493 | Folic Acid Antagonists |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
FDA MoA | N0000187061 | Organic Cation Transporter 2 Inhibitors |
FDA MoA | N0000187062 | Cytochrome P450 2C8 Inhibitors |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:50683 | dihydrofolic acid reductase inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Shigellosis | indication | 36188001 | |
Klebsiella cystitis | indication | 60867007 | |
Urinary tract infectious disease | indication | 68566005 | |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pneumocystosis jiroveci pneumonia | indication | 415125002 | DOID:11339 |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Morganella Morganii Urinary Tract Infection | indication | ||
Staphylococcus Aureus Urinary Tract Infection | indication | ||
Pneumocystis Carinii Pneumonia Prevention | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Infection of skin AND/OR subcutaneous tissue | off-label use | 19824006 | |
Pertussis | off-label use | 27836007 | |
Granuloma inguinale | off-label use | 28867007 | DOID:9113 |
Nocardiosis | off-label use | 29227009 | DOID:2312 |
Listeria meningitis | off-label use | 31568009 | DOID:11572 |
Sinusitis | off-label use | 36971009 | |
Whipple's disease | off-label use | 41545003 | DOID:8476 |
Bacterial pneumonia | off-label use | 53084003 | DOID:874 |
Paracoccidioidomycosis | off-label use | 59925007 | DOID:12662 |
Cholera | off-label use | 63650001 | DOID:1498 |
Brucellosis | off-label use | 75702008 | DOID:11077 |
Paratyphoid fever | off-label use | 85904008 | DOID:3055 |
Chlamydial infection | off-label use | 105629000 | |
Infection of bone | off-label use | 111253001 | |
Meningococcus carrier | off-label use | 170486006 | |
Lymphogranuloma venereum | off-label use | 186946009 | DOID:13819 |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Bacterial endocarditis | off-label use | 301183007 | |
Toxoplasmosis associated with acquired immunodeficiency syndrome | off-label use | 421666009 | |
Toxoplasmosis Prevention | off-label use | ||
Postexposure Plague Prophylaxis | off-label use | ||
Chronic Bacterial Prostatitis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Third trimester pregnancy | contraindication | 41587001 | |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Folic acid deficiency | contraindication | 190633005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 |
Species | Use | Relation |
---|---|---|
Dogs | Systemic antibacterial action against sensitive organisms to surgery | Indication |
Dogs | Systemic antibacterial action against sensitive organisms to debridement | Indication |
Dogs | Control of bacterial infection during the treatment of acute urinary tract infections | Indication |
Dogs | Control of bacterial infection during the treatment of acute bacterial complications of distemper | Indication |
Dogs | Control of bacterial infection during the treatment of acute respiratory tract infections | Indication |
Dogs | Control of bacterial infection during the treatment of acute alimentary tract infections | Indication |
Dogs | Control of bacterial infection during the treatment of wound infections | Indication |
Dogs | Control of bacterial infection during the treatment of abscesses | Indication |
Horses | Systemic antibacterial action against sensitive organisms during treatment of acute strangles | Indication |
Horses | Systemic antibacterial action against sensitive organisms during treatment of respiratory tract infections | Indication |
Horses | Systemic antibacterial action against sensitive organisms during treatment of acute urogenital infections | Indication |
Horses | Systemic antibacterial action against sensitive organisms during treatment of wound infections | Indication |
Horses | Systemic antibacterial action against sensitive organisms during treatment of abscesses | Indication |
Product | Applicant | Ingredients |
---|---|---|
Tribrissen 120 Tablets, Tribrissen 30 Tablets, Tribrissen 480 Tablets, Tribrissen 960 Tablets | Intervet Inc. | 2 |
Tribrissen 24% Injection | Intervet Inc. | 2 |
Tribrissen 48% Injection | Intervet Inc. | 2 |
Di-Trim Tablets | Zoetis Inc. | 2 |
Tribrissen 400 Oral Paste | Intervet Inc. | 2 |
Di-Trim 24% | Zoetis Inc. | 2 |
Di-Trim 48% Injection | Zoetis Inc. | 2 |
Di-Trim 400 Paste | Zoetis Inc. | 2 |
Tribrissen 60 Oral Suspension | Intervet Inc. | 2 |
EQUISUL-SDT | Aurora Pharmaceutical Inc. | 2 |
Uniprim Powder | Neogen Corp. | 2 |
Tucoprim Powder | Zoetis Inc. | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.01 | Basic |
pKa2 | 0.6 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase | Enzyme | Ki | 8 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.25 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | INHIBITOR | IC50 | 5.57 | CHEMBL | CHEMBL | |||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | IC50 | 8.14 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 6.82 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | IC50 | 6.92 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | Ki | 7.99 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 6.30 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 4.84 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 6.88 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 4.92 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | Ki | 6.92 | WOMBAT-PK | |||||
Dihydrofolate reductase | Enzyme | IC50 | 8.66 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 6.72 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 8.89 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | Ki | 6 | WOMBAT-PK | |||||
Dihydrofolate reductase | Enzyme | Ki | 8.92 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | Ki | 8 | WOMBAT-PK | |||||
Dihydrofolate reductase | Enzyme | IC50 | 6.35 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 4.06 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 4.62 | CHEMBL | |||||
Bifunctional dihydrofolate reductase-thymidylate synthase | Enzyme | IC50 | 5.40 | CHEMBL | |||||
Dihydrofolate reductase type 1 | Enzyme | IC50 | 6.30 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | Ki | 8.08 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 4.38 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 6.35 | CHEMBL | |||||
Dihydrofolate reductase | Enzyme | IC50 | 7.04 | CHEMBL |
ID | Source |
---|---|
4017735 | VUID |
N0000146103 | NUI |
D00145 | KEGG_DRUG |
56585-33-2 | SECONDARY_CAS_RN |
60834-30-2 | SECONDARY_CAS_RN |
4017735 | VANDF |
4019528 | VANDF |
C0041041 | UMLSCUI |
CHEBI:45924 | CHEBI |
TOP | PDB_CHEM_ID |
CHEMBL22 | ChEMBL_ID |
DB00440 | DRUGBANK_ID |
CHEMBL2110367 | ChEMBL_ID |
CHEMBL1201080 | ChEMBL_ID |
D014295 | MESH_DESCRIPTOR_UI |
5578 | PUBCHEM_CID |
10931 | IUPHAR_LIGAND_ID |
1047 | INN_ID |
AN164J8Y0X | UNII |
10829 | RXNORM |
3055 | MMSL |
5633 | MMSL |
5634 | MMSL |
d00123 | MMSL |
002873 | NDDF |
008281 | NDDF |
32792001 | SNOMEDCT_US |
387179001 | SNOMEDCT_US |
412323009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 1 mg | OPHTHALMIC | NDA | 19 sections |
Polytrim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-7824 | SOLUTION/ DROPS | 1 mg | OPHTHALMIC | NDA | 19 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0853 | SUSPENSION | 40 mg | ORAL | NDA | 28 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0854 | SUSPENSION | 40 mg | ORAL | NDA | 29 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0854 | SUSPENSION | 40 mg | ORAL | NDA | 29 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-4793 | SUSPENSION | 40 mg | ORAL | ANDA | 28 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0440-2406 | TABLET | 160 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5180 | SUSPENSION | 40 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5180 | SUSPENSION | 40 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5181 | SUSPENSION | 40 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5181 | SUSPENSION | 40 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-8121 | TABLET | 160 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9503 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9503 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9503 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9526 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9526 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9526 | INJECTION, SOLUTION, CONCENTRATE | 16 mg | INTRAVENOUS | ANDA | 31 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0904-2725 | TABLET | 160 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-053 | TABLET | 160 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-092 | TABLET | 160 mg | ORAL | ANDA | 25 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-525 | TABLET | 160 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-926 | TABLET | 160 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-940 | TABLET | 160 mg | ORAL | ANDA | 27 sections |