trimethoprim ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues 2755 738-70-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimethoprim
  • trimethoprim sulfate
  • trimethoprim hydrochloride
  • trimethioprim
  • trimetoprim
  • trimopan
  • trimethoprim HCl
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
  • Molecular weight: 290.32
  • Formula: C14H18N4O3
  • CLOGP: 1.08
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 105.51
  • ALOGS: -2.67
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.37 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 15.75 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 30, 1973 FDA MUTUAL PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Soft tissue disorder 178.45 10.84 81 49266 4341 63435334
Acute kidney injury 160.23 10.84 509 48838 262906 63176769
Drug ineffective 122.82 10.84 411 48936 1044354 62395321
Liver function test abnormal 121.79 10.84 168 49179 48013 63391662
Swelling face 119.80 10.84 193 49154 63282 63376393
Pre-engraftment immune reaction 102.78 10.84 26 49321 212 63439463
Leukopenia 98.42 10.84 198 49149 77092 63362583
Pneumonia viral 96.75 10.84 66 49281 7856 63431819
Hyperkalaemia 94.45 10.84 159 49188 54044 63385631
Pancytopenia 93.46 10.84 222 49125 96711 63342964
Pyrexia 92.15 10.84 653 48694 469825 62969850
Product dose omission issue 86.37 10.84 37 49310 234276 63205399
Stevens-Johnson syndrome 83.49 10.84 100 49247 24850 63414825
Hyponatraemia 77.94 10.84 227 49120 111673 63328002
Encephalitis viral 77.15 10.84 34 49313 1698 63437977
Completed suicide 68.00 10.84 15 49332 145658 63294017
Rash maculo-papular 65.72 10.84 101 49246 31795 63407880
Cytomegalovirus infection 63.67 10.84 80 49267 20872 63418803
Lip swelling 63.49 10.84 98 49249 30965 63408710
Injection site pain 63.42 10.84 12 49335 129788 63309887
Abdominal discomfort 62.96 10.84 95 49252 320790 63118885
Fatigue 62.84 10.84 419 48928 887609 62552066
Human herpesvirus 6 infection 62.62 10.84 35 49312 2922 63436753
Alopecia 61.45 10.84 105 49242 337431 63102244
Allergy to chemicals 59.01 10.84 34 49313 3008 63436667
Tenosynovitis stenosans 58.42 10.84 35 49312 3329 63436346
Ejection fraction decreased 58.11 10.84 79 49268 22253 63417422
Product use issue 57.52 10.84 52 49295 220468 63219207
Systemic lupus erythematosus 56.02 10.84 48 49299 208870 63230805
Synovial fluid analysis 54.82 10.84 30 49317 2403 63437272
International normalised ratio increased 54.44 10.84 115 49232 46310 63393365
Off label use 53.98 10.84 306 49041 674156 62765519
Scleritis 51.97 10.84 36 49311 4392 63435283
Toxic epidermal necrolysis 50.48 10.84 79 49268 25255 63414420
Kidney transplant rejection 48.43 10.84 34 49313 4237 63435438
Maternal exposure during pregnancy 48.32 10.84 60 49287 220002 63219673
Tenderness 47.22 10.84 72 49275 22506 63417169
Photophobia 46.82 10.84 63 49284 17572 63422103
Pleuritic pain 46.25 10.84 43 49304 7986 63431689
Conjunctivitis 45.89 10.84 68 49279 20728 63418947
Psoriasis 44.75 10.84 7 49340 86950 63352725
Death 43.82 10.84 147 49200 374234 63065441
Blood pressure increased 43.72 10.84 37 49310 162025 63277650
Hypophagia 43.30 10.84 83 49264 31176 63408499
Confusional state 43.16 10.84 323 49024 236057 63203618
Genital ulceration 43.15 10.84 17 49330 638 63439037
Mouth swelling 43.04 10.84 33 49314 4707 63434968
Deep vein thrombosis 42.87 10.84 153 49194 83647 63356028
Oral pain 42.58 10.84 78 49269 28316 63411359
Pemphigus 42.56 10.84 48 49299 183678 63255997
Macular degeneration 41.77 10.84 71 49276 24305 63415370
Swollen tongue 41.73 10.84 87 49260 34713 63404962
Urosepsis 41.49 10.84 61 49286 18463 63421212
Thrombocytopenia 41.45 10.84 229 49118 150928 63288747
Drug reaction with eosinophilia and systemic symptoms 41.05 10.84 85 49262 33751 63405924
Intentional overdose 40.44 10.84 5 49342 74147 63365528
Fear of eating 39.89 10.84 14 49333 378 63439297
Superinfection 39.85 10.84 25 49322 2582 63437093
Drug interaction 39.54 10.84 309 49038 228822 63210853
Renal failure 38.31 10.84 187 49160 117465 63322210
Genital pain 37.98 10.84 14 49333 437 63439238
Psoriatic arthropathy 37.81 10.84 12 49335 91508 63348167
Anaemia 37.79 10.84 371 48976 293059 63146616
Bone marrow failure 37.21 10.84 75 49272 29215 63410460
Pain 36.97 10.84 383 48964 740245 62699430
Crepitations 36.86 10.84 38 49309 8002 63431673
Glossodynia 35.97 10.84 52 49295 178824 63260851
Inappropriate schedule of product administration 35.82 10.84 18 49329 103947 63335728
Blood creatinine increased 35.62 10.84 149 49198 87695 63351980
Nasopharyngitis 35.40 10.84 92 49255 254165 63185510
Agranulocytosis 35.13 10.84 67 49280 25067 63414608
Abdominal pain 34.89 10.84 365 48982 293091 63146584
Intentional product use issue 34.73 10.84 29 49318 127863 63311812
Fibromyalgia 34.66 10.84 139 49208 80281 63359394
Oral candidiasis 34.65 10.84 63 49284 22735 63416940
Fall 34.63 10.84 172 49175 392162 63047513
Arthropathy 34.20 10.84 83 49264 234709 63204966
Injection site erythema 34.20 10.84 11 49336 83163 63356512
Cushingoid 33.42 10.84 37 49310 8448 63431227
Platelet count decreased 32.54 10.84 177 49170 115945 63323730
Injection site reaction 31.78 10.84 4 49343 58520 63381155
Pneumocystis jirovecii pneumonia 31.30 10.84 51 49296 16863 63422812
Atelectasis 30.94 10.84 58 49289 21425 63418250
Bacterial sepsis 30.46 10.84 25 49322 3933 63435742
COVID-19 30.28 10.84 26 49321 113077 63326598
Deformity 29.89 10.84 41 49306 11643 63428032
Transplant rejection 29.37 10.84 39 49308 10741 63428934
Rash erythematous 29.34 10.84 86 49261 42424 63397251
Angioedema 29.33 10.84 93 49254 47872 63391803
Suicide attempt 28.97 10.84 6 49341 60912 63378763
Infusion related reaction 28.97 10.84 96 49251 245425 63194250
Complications of transplanted kidney 28.68 10.84 20 49327 2466 63437209
Documented hypersensitivity to administered product 28.55 10.84 12 49335 533 63439142
Neutropenic sepsis 28.32 10.84 48 49299 16390 63423285
Parkinsonian rest tremor 28.11 10.84 8 49339 106 63439569
HIV infection 27.94 10.84 11 49336 412 63439263
Drug abuse 27.41 10.84 11 49336 72507 63367168
Pulmonary toxicity 26.98 10.84 35 49312 9420 63430255
Discomfort 26.95 10.84 56 49291 167318 63272357
Herpes zoster 26.79 10.84 131 49216 82331 63357344
Excessive eye blinking 26.70 10.84 15 49332 1265 63438410
Arthralgia 26.60 10.84 299 49048 569411 62870264
Rash pruritic 26.27 10.84 104 49243 59695 63379980
Ureteric obstruction 26.26 10.84 17 49330 1853 63437822
Vaginal discharge 26.18 10.84 34 49313 9164 63430511
Cholecystitis chronic 25.97 10.84 36 49311 10325 63429350
Synovial cyst 25.78 10.84 36 49311 10397 63429278
Ocular hyperaemia 25.75 10.84 59 49288 25085 63414590
Muscle twitching 25.75 10.84 51 49296 19617 63420058
Blood pressure fluctuation 25.56 10.84 3 49344 46314 63393361
Infection 25.33 10.84 281 49066 228892 63210783
Treatment failure 24.75 10.84 76 49271 198967 63240708
Meningoencephalitis herpetic 24.60 10.84 14 49333 1210 63438465
Flank pain 24.50 10.84 45 49302 16365 63423310
Potentiating drug interaction 24.46 10.84 23 49324 4333 63435342
Wrong technique in product usage process 24.32 10.84 9 49338 62331 63377344
Vulvovaginal candidiasis 24.32 10.84 20 49327 3155 63436520
Feeling jittery 24.24 10.84 40 49307 13363 63426312
Bacterial test positive 24.18 10.84 25 49322 5282 63434393
Hepatic cytolysis 23.96 10.84 43 49304 15364 63424311
Rectal haemorrhage 23.78 10.84 88 49259 48942 63390733
Rheumatoid arthritis 23.69 10.84 109 49238 253710 63185965
Wound 23.54 10.84 58 49289 163205 63276470
Influenza 23.47 10.84 30 49317 108692 63330983
Mucosal inflammation 23.41 10.84 85 49262 46843 63392832
Toxicity to various agents 23.18 10.84 106 49241 247144 63192531
Rheumatoid factor positive 23.08 10.84 19 49328 84387 63355288
Contraindicated product administered 23.07 10.84 89 49258 217559 63222116
Seizure 22.92 10.84 179 49168 132455 63307220
Multiple organ dysfunction syndrome 22.79 10.84 96 49251 56656 63383019
Chronic sinusitis 22.79 10.84 38 49309 12805 63426870
Injection site bruising 22.43 10.84 3 49344 41907 63397768
Vomiting 22.38 10.84 581 48766 559036 62880639
Blindness cortical 22.36 10.84 10 49337 517 63439158
Pregnancy with injectable contraceptive 22.26 10.84 7 49340 133 63439542
Urinary tract infection 22.13 10.84 308 49039 264376 63175299
Eye pain 21.95 10.84 67 49280 33787 63405888
Antinuclear antibody positive 21.88 10.84 29 49318 7970 63431705
Red blood cell sedimentation rate increased 21.61 10.84 4 49343 43978 63395697
Cystitis noninfective 21.59 10.84 12 49335 991 63438684
Acquired immunodeficiency syndrome 20.85 10.84 6 49341 83 63439592
Hepatitis fulminant 20.82 10.84 19 49328 3445 63436230
Trimethylaminuria 20.80 10.84 7 49340 166 63439509
Renal tubular disorder 20.76 10.84 17 49330 2665 63437010
Deafness transitory 20.76 10.84 15 49332 1955 63437720
Blood sodium decreased 20.65 10.84 53 49294 24199 63415476
Clostridial infection 20.57 10.84 21 49326 4371 63435304
Body mass index decreased 20.50 10.84 9 49338 445 63439230
Pulmonary embolism 20.45 10.84 158 49189 116526 63323149
White blood cell count decreased 20.44 10.84 181 49166 138923 63300752
Weight increased 20.39 10.84 119 49228 260673 63179002
Effusion 20.24 10.84 14 49333 1704 63437971
Bronchopulmonary aspergillosis 20.16 10.84 29 49318 8606 63431069
Injection site swelling 20.07 10.84 6 49341 47566 63392109
Blood pressure systolic increased 19.96 10.84 6 49341 47391 63392284
Hospitalisation 19.94 10.84 22 49325 85059 63354616
Foaming at mouth 19.89 10.84 12 49335 1156 63438519
Palmar erythema 19.88 10.84 14 49333 1753 63437922
Cholelithiasis 19.78 10.84 77 49270 43848 63395827
Pseudomonas infection 19.66 10.84 33 49314 11180 63428495
Osteoporosis 19.63 10.84 10 49337 57328 63382347
Renal tubular necrosis 19.56 10.84 34 49313 11844 63427831
Soft tissue swelling 19.19 10.84 12 49335 1232 63438443
Blood cholesterol increased 19.16 10.84 132 49215 93900 63345775
Septic shock 18.95 10.84 102 49245 66527 63373148
Inappropriate antidiuretic hormone secretion 18.94 10.84 39 49308 15423 63424252
Intentional product misuse 18.89 10.84 12 49335 60905 63378770
Loss of personal independence in daily activities 18.85 10.84 29 49318 97261 63342414
Leukoencephalopathy 18.70 10.84 20 49327 4393 63435282
Tubulointerstitial nephritis 18.53 10.84 45 49302 19858 63419817
Libido disorder 18.42 10.84 5 49342 55 63439620
Aplasia pure red cell 18.42 10.84 20 49327 4467 63435208
Tenosynovitis 18.33 10.84 36 49311 13759 63425916
Hepatic enzyme increased 18.22 10.84 88 49259 202240 63237435
Fluid retention 18.18 10.84 12 49335 59674 63380001
Arthritis 18.16 10.84 153 49194 115768 63323907
Chemotherapeutic drug level increased 18.13 10.84 6 49341 135 63439540
Immune reconstitution inflammatory syndrome 18.11 10.84 23 49324 6061 63433614
Bone density decreased 18.06 10.84 37 49310 14575 63425100
Urine output decreased 18.02 10.84 32 49315 11338 63428337
Pericarditis 17.99 10.84 48 49299 131531 63308144
No adverse event 17.88 10.84 5 49342 41400 63398275
Haemoglobin decreased 17.75 10.84 182 49165 145303 63294372
Neutropenia 17.72 10.84 211 49136 174794 63264881
Dehydration 17.54 10.84 209 49138 173145 63266530
Device expulsion 17.54 10.84 3 49344 34919 63404756
Sinusitis 17.41 10.84 104 49243 226549 63213126
Breast cancer 17.23 10.84 8 49339 48375 63391300
Physical assault 17.07 10.84 10 49337 913 63438762
Hiccups 16.98 10.84 14 49333 2217 63437458
Angiodermatitis 16.94 10.84 5 49342 76 63439599
Dermatitis exfoliative 16.83 10.84 21 49326 5438 63434237
Lethargy 16.79 10.84 87 49260 55920 63383755
Mental status changes 16.70 10.84 68 49279 39531 63400144
Pseudomembranous colitis 16.65 10.84 16 49331 3096 63436579
Nasal congestion 16.49 10.84 16 49331 65644 63374031
Adverse event 16.35 10.84 17 49330 67542 63372133
Joint effusion 16.34 10.84 39 49308 17021 63422654
Cogwheel rigidity 16.34 10.84 13 49334 1957 63437718
Immunosuppressant drug level increased 16.32 10.84 17 49330 3621 63436054
Febrile bone marrow aplasia 16.23 10.84 24 49323 7301 63432374
Antinuclear antibody 16.20 10.84 8 49339 518 63439157
Gastrointestinal pain 16.12 10.84 28 49319 9748 63429927
Liver function test increased 16.09 10.84 3 49344 32808 63406867
Synovial disorder 15.91 10.84 13 49334 2032 63437643
Blood culture positive 15.87 10.84 19 49328 4716 63434959
Liver disorder 15.82 10.84 83 49264 53604 63386071
Purpura senile 15.69 10.84 8 49339 555 63439120
Meningitis aseptic 15.59 10.84 19 49328 4804 63434871
Left ventricular dysfunction 15.59 10.84 31 49316 11957 63427718
Tarsal tunnel syndrome 15.54 10.84 8 49339 566 63439109
Haemorrhoids 15.46 10.84 45 49302 22105 63417570
Migraine 15.45 10.84 36 49311 103310 63336365
Anti-cyclic citrullinated peptide antibody positive 15.43 10.84 43 49304 116169 63323506
Vestibular disorder 15.32 10.84 11 49336 1420 63438255
Proctitis 15.31 10.84 20 49327 5421 63434254
Paraesthesia oral 15.29 10.84 41 49306 19215 63420460
Blood alkaline phosphatase increased 15.21 10.84 70 49277 42897 63396778
Oliguria 14.92 10.84 26 49321 9075 63430600
Subdural haemorrhage 14.77 10.84 15 49332 3103 63436572
Acute respiratory distress syndrome 14.72 10.84 46 49301 23488 63416187
Impaired work ability 14.68 10.84 38 49309 17437 63422238
Jaundice 14.60 10.84 53 49294 29198 63410477
Lung transplant rejection 14.45 10.84 9 49338 918 63438757
Malaise 14.37 10.84 424 48923 415530 63024145
Procedural pain 14.28 10.84 43 49304 21526 63418149
Lung disorder 14.25 10.84 90 49257 62171 63377504
Hepatitis 14.22 10.84 65 49282 39723 63399952
Cushing's syndrome 14.19 10.84 8 49339 679 63438996
Vaginal flatulence 14.09 10.84 15 49332 3278 63436397
Hepatic failure 14.07 10.84 60 49287 35596 63404079
Citrobacter infection 13.99 10.84 7 49340 466 63439209
Pain in extremity 13.89 10.84 178 49169 331308 63108367
Genital burning sensation 13.88 10.84 6 49341 286 63439389
Tonsillar hypertrophy 13.81 10.84 9 49338 992 63438683
Alanine aminotransferase increased 13.71 10.84 132 49215 103638 63336037
Pustule 13.64 10.84 11 49336 1688 63437987
Asthma 13.61 10.84 52 49295 127509 63312166
Unevaluable event 13.52 10.84 12 49335 51374 63388301
Hypovolaemic shock 13.19 10.84 20 49327 6221 63433454
Hydronephrosis 13.18 10.84 27 49320 10635 63429040
Depression 13.14 10.84 94 49253 196398 63243277
Cataract 13.09 10.84 15 49332 57038 63382637
Herpes simplex viraemia 13.07 10.84 6 49341 330 63439345
Stress 13.03 10.84 20 49327 67147 63372528
Areflexia 12.98 10.84 14 49333 3104 63436571
Axillary vein thrombosis 12.92 10.84 6 49341 339 63439336
Altered visual depth perception 12.85 10.84 6 49341 343 63439332
Memory impairment 12.81 10.84 40 49307 104218 63335457
HIV wasting syndrome 12.80 10.84 3 49344 17 63439658
Dermatitis allergic 12.79 10.84 33 49314 15115 63424560
Muscle haemorrhage 12.76 10.84 14 49333 3165 63436510
Sepsis 12.70 10.84 178 49169 152945 63286730
Disseminated intravascular coagulation 12.63 10.84 38 49309 19013 63420662
Neutrophil count decreased 12.58 10.84 81 49266 56325 63383350
Hypoaesthesia 12.54 10.84 78 49269 168315 63271360
Mobility decreased 12.54 10.84 50 49297 121109 63318566
Aspartate aminotransferase increased 12.50 10.84 116 49231 90161 63349514
Porphyria acute 12.49 10.84 9 49338 1168 63438507
Dialysis 12.42 10.84 26 49321 10401 63429274
Escherichia test positive 12.27 10.84 12 49335 2372 63437303
Gait disturbance 12.07 10.84 88 49259 183090 63256585
Graft versus host disease 11.98 10.84 20 49327 6743 63432932
Lip ulceration 11.85 10.84 11 49336 2039 63437636
Ataxia 11.71 10.84 32 49315 15163 63424512
Nail infection 11.70 10.84 12 49335 2511 63437164
Plasma cell myeloma 11.62 10.84 57 49290 35848 63403827
Cytomegalovirus test positive 11.61 10.84 13 49334 3005 63436670
Renal tubular acidosis 11.60 10.84 10 49337 1682 63437993
Vaginal ulceration 11.58 10.84 6 49341 430 63439245
Pleural effusion 11.55 10.84 117 49230 93093 63346582
Abnormal loss of weight 11.47 10.84 18 49329 5764 63433911
Drug hypersensitivity 11.35 10.84 319 49028 310368 63129307
Intentional self-injury 11.28 10.84 3 49344 25684 63413991
Defaecation urgency 11.21 10.84 15 49332 4160 63435515
Hypersensitivity pneumonitis 11.21 10.84 12 49335 2638 63437037
Circulatory collapse 11.16 10.84 40 49307 21898 63417777
Eye irritation 11.13 10.84 40 49307 21931 63417744
Retinal detachment 11.05 10.84 18 49329 5951 63433724
Blood folate decreased 11.03 10.84 7 49340 737 63438938
Functional gastrointestinal disorder 10.98 10.84 15 49332 4244 63435431
Apraxia 10.97 10.84 10 49337 1811 63437864
Joint range of motion decreased 10.87 10.84 52 49295 32376 63407299

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 178.29 11.27 118 37687 419406 34499720
Hyperkalaemia 159.03 11.27 276 37529 69113 34850013
Drug ineffective 156.23 11.27 159 37646 456592 34462534
Pyrexia 154.26 11.27 739 37066 332274 34586852
Acute kidney injury 126.30 11.27 656 37149 304332 34614794
Neutropenia 110.14 11.27 396 37409 156382 34762744
Death 95.25 11.27 179 37626 397870 34521256
Blood creatinine increased 92.10 11.27 268 37537 94708 34824418
Pancytopenia 87.02 11.27 263 37542 94894 34824232
Drug abuse 86.98 11.27 5 37800 99091 34820035
Stevens-Johnson syndrome 86.90 11.27 104 37701 18535 34900591
Immune reconstitution inflammatory syndrome 85.60 11.27 73 37732 8686 34910440
Cytomegalovirus infection 81.88 11.27 120 37685 26015 34893111
Completed suicide 75.08 11.27 9 37796 98159 34820967
Product dose omission issue 70.42 11.27 21 37784 119690 34799436
Transplant rejection 66.14 11.27 68 37737 10243 34908883
Product use in unapproved indication 53.89 11.27 30 37775 117469 34801657
Hepatic cytolysis 53.48 11.27 72 37733 14424 34904702
Product use issue 53.07 11.27 4 37801 63212 34855914
Kidney transplant rejection 50.92 11.27 51 37754 7446 34911680
Thrombocytopenia 50.45 11.27 315 37490 155932 34763194
Cellulitis enterococcal 47.80 11.27 13 37792 100 34919026
Agranulocytosis 47.15 11.27 89 37716 23732 34895394
Leukopenia 45.91 11.27 161 37644 62695 34856431
Fatigue 45.17 11.27 227 37578 370426 34548700
Renal tubular necrosis 43.43 11.27 68 37737 15612 34903514
Inappropriate schedule of product administration 42.37 11.27 8 37797 62288 34856838
Pneumocystis jirovecii pneumonia 41.97 11.27 76 37729 19634 34899492
Aspartate aminotransferase increased 41.47 11.27 164 37641 67619 34851507
Pre-engraftment immune reaction 40.06 11.27 11 37794 88 34919038
Haemodialysis 39.93 11.27 53 37752 10473 34908653
Alanine aminotransferase increased 37.56 11.27 180 37625 80635 34838491
Blood lactate dehydrogenase increased 37.23 11.27 79 37726 22911 34896215
Blood bilirubin increased 36.99 11.27 108 37697 38188 34880938
Hepatitis 36.26 11.27 80 37725 23824 34895302
Cholestasis 36.25 11.27 86 37719 26862 34892264
Lymphocyte count decreased 35.79 11.27 77 37728 22545 34896581
Anal inflammation 34.51 11.27 20 37785 1280 34917846
Blood urea increased 33.62 11.27 90 37715 30274 34888852
Weight increased 33.18 11.27 31 37774 93002 34826124
Toxicity to various agents 32.26 11.27 110 37695 200252 34718874
Osteoporotic fracture 32.17 11.27 18 37787 1077 34918049
Respiratory tract infection bacterial 31.09 11.27 21 37784 1761 34917365
Respiratory tract infection viral 30.97 11.27 24 37781 2493 34916633
SARS-CoV-2 test negative 30.60 11.27 17 37788 1003 34918123
Rash 29.90 11.27 370 37435 222382 34696744
Aplasia pure red cell 29.87 11.27 35 37770 6097 34913029
Platelet count decreased 29.50 11.27 226 37579 119491 34799635
Rash maculo-papular 29.18 11.27 82 37723 28369 34890757
Proctalgia 28.43 11.27 33 37772 5690 34913436
Plasma cell myeloma 28.40 11.27 105 37700 41932 34877194
Hospitalisation 28.36 11.27 13 37792 56889 34862237
Toxic skin eruption 28.29 11.27 47 37758 11338 34907788
Encephalitis viral 27.88 11.27 17 37788 1195 34917931
Liver transplant rejection 27.82 11.27 21 37784 2098 34917028
Fall 27.74 11.27 119 37686 202766 34716360
Dialysis 27.49 11.27 46 37759 11162 34907964
Blood alkaline phosphatase increased 27.35 11.27 85 37720 31090 34888036
Body temperature increased 27.34 11.27 59 37746 17309 34901817
Renal failure 27.06 11.27 237 37568 130320 34788806
HIV infection 26.32 11.27 17 37788 1322 34917804
Blood antidiuretic hormone increased 26.31 11.27 7 37798 49 34919077
Intestinal intraepithelial lymphocytes increased 26.20 11.27 9 37796 161 34918965
Cerebrovascular accident 26.07 11.27 32 37773 84779 34834347
Therapeutic product effect incomplete 26.05 11.27 11 37794 50530 34868596
Asthma 25.95 11.27 7 37798 42649 34876477
Liver function test abnormal 25.68 11.27 83 37722 30991 34888135
Hepatitis cholestatic 25.62 11.27 37 37768 7910 34911216
Drug reaction with eosinophilia and systemic symptoms 25.34 11.27 86 37719 32926 34886200
Acquired immunodeficiency syndrome 25.33 11.27 12 37793 506 34918620
Chills 25.23 11.27 162 37643 80881 34838245
Intentional overdose 25.05 11.27 8 37797 43666 34875460
Intentional product use issue 25.00 11.27 17 37788 59799 34859327
Pneumonia cytomegaloviral 24.94 11.27 23 37782 3031 34916095
Rash morbilliform 24.73 11.27 23 37782 3064 34916062
Kaposi's sarcoma 24.55 11.27 14 37791 869 34918257
Aspergillus infection 24.51 11.27 46 37759 12208 34906918
Jaundice 24.42 11.27 83 37722 31799 34887327
Proteus infection 24.13 11.27 15 37790 1091 34918035
Graft versus host disease 24.10 11.27 42 37763 10527 34908599
Bone marrow failure 24.05 11.27 78 37727 29175 34889951
Lymphocele 23.69 11.27 16 37789 1341 34917785
Blood potassium increased 23.67 11.27 54 37751 16441 34902685
Cryptitis 23.32 11.27 9 37796 227 34918899
Hepatomegaly 23.30 11.27 41 37764 10355 34908771
Tubulointerstitial nephritis 22.95 11.27 62 37743 20962 34898164
Culture urine positive 22.90 11.27 15 37790 1195 34917931
Injection site pain 22.63 11.27 7 37798 38998 34880128
Peripheral swelling 22.37 11.27 30 37775 76511 34842615
Hepatosplenomegaly 22.34 11.27 25 37780 4144 34914982
Renal papillary necrosis 22.28 11.27 8 37797 164 34918962
Nasopharyngitis 21.93 11.27 26 37779 69942 34849184
Intentional product misuse 21.84 11.27 11 37794 45600 34873526
Foetal exposure during pregnancy 21.81 11.27 7 37798 38094 34881032
SARS-CoV-2 antibody test positive 21.28 11.27 10 37795 414 34918712
Treatment failure 21.28 11.27 12 37793 46685 34872441
Leukaemia recurrent 21.19 11.27 16 37789 1599 34917527
Microvillous inclusion disease 21.10 11.27 8 37797 192 34918934
Drug intolerance 21.06 11.27 20 37785 59550 34859576
Neutrophil count decreased 21.02 11.27 110 37695 50994 34868132
Motion sickness 20.99 11.27 8 37797 195 34918931
Mental status changes 20.79 11.27 89 37716 37994 34881132
Therapeutic product effect decreased 20.58 11.27 6 37799 34737 34884389
Dyspnoea 20.43 11.27 286 37519 376496 34542630
White blood cell count decreased 20.15 11.27 174 37631 95271 34823855
Haemorrhoids 20.12 11.27 47 37758 14528 34904598
Dermatitis exfoliative 20.08 11.27 30 37775 6609 34912517
Probiotic therapy 19.99 11.27 7 37798 133 34918993
Wrong technique in product usage process 19.92 11.27 7 37798 35979 34883147
Gamma-glutamyltransferase increased 19.73 11.27 73 37732 29158 34889968
Human herpesvirus 6 infection 19.63 11.27 17 37788 2064 34917062
Clonal haematopoiesis 19.23 11.27 6 37799 78 34919048
Biopsy liver abnormal 19.16 11.27 7 37798 151 34918975
Joint swelling 19.04 11.27 22 37783 59868 34859258
Apoptosis 18.52 11.27 9 37796 402 34918724
Lung infiltration 18.24 11.27 42 37763 12863 34906263
Serum sickness 18.18 11.27 16 37789 1984 34917142
Ureteric obstruction 17.99 11.27 13 37792 1215 34917911
Biopsy 17.64 11.27 8 37797 305 34918821
Viral test positive 17.29 11.27 7 37798 201 34918925
Haemoglobin decreased 17.20 11.27 203 37602 120569 34798557
Rheumatoid arthritis 17.17 11.27 10 37795 38228 34880898
Myocardial infarction 17.16 11.27 70 37735 121015 34798111
Chronic lymphocytic leukaemia 17.12 11.27 22 37783 4210 34914916
Phlebitis 17.06 11.27 21 37784 3849 34915277
Renal tubular disorder 17.03 11.27 23 37782 4620 34914506
Dizziness 16.90 11.27 153 37652 218368 34700758
Escherichia urinary tract infection 16.87 11.27 20 37785 3526 34915600
Suicide attempt 16.50 11.27 11 37794 39105 34880021
Oesophageal candidiasis 16.46 11.27 22 37783 4374 34914752
Psoriasis 16.26 11.27 11 37794 38801 34880325
Syncope 16.24 11.27 48 37757 91403 34827723
Culture stool positive 15.97 11.27 7 37798 246 34918880
Enterovirus infection 15.74 11.27 11 37794 975 34918151
Idiopathic pneumonia syndrome 15.53 11.27 7 37798 263 34918863
Toxic epidermal necrolysis 15.40 11.27 55 37750 21591 34897535
Dehydration 15.34 11.27 211 37594 129758 34789368
Vomiting 15.33 11.27 363 37442 247258 34671868
Febrile neutropenia 15.28 11.27 220 37585 136629 34782497
Cytomegalovirus chorioretinitis 15.06 11.27 19 37786 3570 34915556
Erythema infectiosum 15.03 11.27 6 37799 166 34918960
Blood culture positive 15.03 11.27 22 37783 4761 34914365
Liver transplant 14.97 11.27 16 37789 2518 34916608
Parkinsonism hyperpyrexia syndrome 14.85 11.27 5 37800 84 34919042
Orbital haemorrhage 14.79 11.27 4 37801 30 34919096
Myositis 14.61 11.27 37 37768 12033 34907093
HIV wasting syndrome 14.58 11.27 5 37800 89 34919037
Photosensitivity reaction 14.45 11.27 34 37771 10560 34908566
Loss of personal independence in daily activities 14.45 11.27 9 37796 33170 34885956
Lymphadenopathy 14.38 11.27 65 37740 28398 34890728
Renal tubular acidosis 14.34 11.27 15 37790 2304 34916822
Drug ineffective for unapproved indication 14.22 11.27 4 37801 23711 34895415
Complications of transplanted kidney 14.19 11.27 21 37784 4588 34914538
Vena cava injury 13.99 11.27 7 37798 333 34918793
Light chain analysis decreased 13.96 11.27 4 37801 38 34919088
Lymphocytic infiltration 13.86 11.27 9 37796 706 34918420
Wound evisceration 13.64 11.27 5 37800 109 34919017
Acute graft versus host disease in skin 13.63 11.27 22 37783 5179 34913947
Peripheral motor neuropathy 13.48 11.27 13 37792 1813 34917313
Hepatic steatosis 13.36 11.27 47 37758 18315 34900811
Mycobacterium avium complex infection 13.35 11.27 15 37790 2496 34916630
Thrombotic microangiopathy 13.30 11.27 33 37772 10597 34908529
Hepatitis A antibody positive 13.27 11.27 4 37801 46 34919080
Sleep disorder 13.25 11.27 9 37796 31679 34887447
C-reactive protein increased 13.23 11.27 102 37703 53996 34865130
Cytomegalovirus test 13.19 11.27 4 37801 47 34919079
Stent removal 12.88 11.27 3 37802 11 34919115
Enterococcal infection 12.84 11.27 30 37775 9276 34909850
Transplant dysfunction 12.70 11.27 15 37790 2634 34916492
Cystic lymphangioma 12.68 11.27 3 37802 12 34919114
Optic neuropathy 12.67 11.27 13 37792 1952 34917174
Therapeutic product effect prolonged 12.62 11.27 6 37799 255 34918871
Cytomegalovirus viraemia 12.57 11.27 26 37779 7404 34911722
Hepatitis B antibody positive 12.55 11.27 4 37801 56 34919070
Immunosuppressant drug level increased 12.45 11.27 23 37782 6032 34913094
Malignant neoplasm progression 12.40 11.27 51 37754 87995 34831131
Blood calcium decreased 12.30 11.27 31 37774 10053 34909073
Wound infection 12.25 11.27 25 37780 7054 34912072
Laryngeal pain 12.19 11.27 15 37790 2749 34916377
Granulomatous rosacea 12.11 11.27 5 37800 151 34918975
Parvovirus infection 12.11 11.27 7 37798 446 34918680
Suprapubic pain 12.08 11.27 7 37798 448 34918678
Lymphopenia 12.05 11.27 42 37763 16293 34902833
Acute myocardial infarction 12.03 11.27 25 37780 53694 34865432
Heart rate decreased 12.00 11.27 10 37795 31735 34887391
Hepatitis C virus test 11.95 11.27 4 37801 66 34919060
Febrile bone marrow aplasia 11.91 11.27 27 37778 8182 34910944
Blood pressure increased 11.82 11.27 52 37753 88050 34831076
Product prescribing error 11.79 11.27 5 37800 22922 34896204
Sedation 11.78 11.27 4 37801 21002 34898124
Autoimmune haemolytic anaemia 11.76 11.27 19 37786 4477 34914649
Arthritis 11.70 11.27 10 37795 31336 34887790
Blood chloride increased 11.69 11.27 15 37790 2866 34916260
Granulomatosis with polyangiitis 11.68 11.27 10 37795 1195 34917931
Biliary sepsis 11.65 11.27 8 37797 689 34918437
Epidermal necrosis 11.58 11.27 7 37798 484 34918642
Rectal prolapse 11.57 11.27 7 37798 485 34918641
COVID-19 11.51 11.27 44 37761 77506 34841620
Heart transplant rejection 11.50 11.27 10 37795 1221 34917905
Refusal of treatment by patient 11.48 11.27 20 37785 5012 34914114
Accident 11.43 11.27 20 37785 5027 34914099
Cytotoxic oedema 11.40 11.27 5 37800 176 34918950
Complications of transplant surgery 11.34 11.27 7 37798 503 34918623
Acute graft versus host disease in liver 11.28 11.27 11 37794 1555 34917571

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 246.16 10.31 1009 69558 518395 79155426
Hyperkalaemia 235.13 10.31 388 70179 114010 79559811
Drug ineffective 177.54 10.31 439 70128 1080474 78593347
Pyrexia 145.44 10.31 1062 69505 677647 78996174
Pre-engraftment immune reaction 141.25 10.31 37 70530 304 79673517
Off label use 139.87 10.31 380 70187 906835 78766986
Completed suicide 136.52 10.31 26 70541 245741 79428080
Stevens-Johnson syndrome 130.38 10.31 167 70400 38999 79634822
Pancytopenia 113.87 10.31 364 70203 165381 79508440
Product dose omission issue 111.26 10.31 40 70527 247497 79426324
Death 107.46 10.31 212 70355 566302 79107519
Encephalitis viral 106.64 10.31 50 70517 2529 79671292
Swelling face 103.55 10.31 208 70359 71004 79602817
Drug abuse 97.46 10.31 14 70553 162677 79511144
Blood creatinine increased 93.58 10.31 326 70241 154731 79519090
Cytomegalovirus infection 88.00 10.31 145 70422 42499 79631322
Liver function test abnormal 87.45 10.31 183 70384 64292 79609529
Soft tissue disorder 86.47 10.31 48 70519 3467 79670354
Leukopenia 79.18 10.31 255 70312 116258 79557563
Injection site pain 78.17 10.31 11 70556 129827 79543994
Human herpesvirus 6 infection 77.19 10.31 52 70515 5318 79668503
Immune reconstitution inflammatory syndrome 76.84 10.31 77 70490 13764 79660057
Kidney transplant rejection 76.10 10.31 67 70500 10179 79663642
Fatigue 72.47 10.31 504 70063 929223 78744598
Transplant rejection 69.65 10.31 86 70481 19351 79654470
Product use issue 67.62 10.31 52 70515 209770 79464051
Hyponatraemia 65.37 10.31 321 70246 177527 79496294
Drug reaction with eosinophilia and systemic symptoms 61.45 10.31 159 70408 64085 79609736
Inappropriate schedule of product administration 61.02 10.31 21 70546 133607 79540214
Pneumonia viral 60.37 10.31 56 70511 9102 79664719
Neutropenia 60.03 10.31 448 70119 287262 79386559
Allergy to chemicals 59.85 10.31 34 70533 2568 79671253
Thrombocytopenia 59.34 10.31 420 70147 264839 79408982
Rash maculo-papular 58.03 10.31 143 70424 55935 79617886
Toxicity to various agents 57.14 10.31 187 70380 421353 79252468
Intentional overdose 57.14 10.31 12 70555 105948 79567873
Tenosynovitis stenosans 57.10 10.31 35 70532 3043 79670778
International normalised ratio increased 54.47 10.31 182 70385 84539 79589282
Synovial fluid analysis 52.05 10.31 30 70537 2329 79671492
Fall 51.57 10.31 239 70328 487390 79186431
Scleritis 50.54 10.31 37 70530 4319 79669502
Haemodialysis 49.08 10.31 70 70497 18098 79655723
Lip swelling 48.49 10.31 110 70457 40801 79633020
Renal failure 47.75 10.31 323 70244 200645 79473176
Wrong technique in product usage process 47.55 10.31 5 70562 73870 79599951
Nasopharyngitis 47.16 10.31 96 70471 253785 79420036
Psoriasis 46.58 10.31 11 70556 89576 79584245
Fear of eating 46.39 10.31 17 70550 456 79673365
Renal tubular necrosis 46.18 10.31 81 70486 24958 79648863
Rash 45.40 10.31 741 69826 577617 79096204
Blood pressure increased 44.51 10.31 74 70493 211286 79462535
Agranulocytosis 42.60 10.31 111 70456 44919 79628902
Toxic epidermal necrolysis 42.28 10.31 110 70457 44471 79629350
Platelet count decreased 41.63 10.31 305 70262 194359 79479462
Intentional product use issue 41.47 10.31 44 70523 152068 79521753
Pneumocystis jirovecii pneumonia 41.45 10.31 90 70477 32418 79641403
Genital ulceration 41.43 10.31 20 70547 1080 79672741
Photophobia 41.27 10.31 69 70498 20459 79653362
Ureteric obstruction 40.72 10.31 27 70540 2689 79671132
Intentional product misuse 40.04 10.31 17 70550 95148 79578673
Conjunctivitis 39.64 10.31 77 70490 25638 79648183
Urosepsis 39.22 10.31 78 70489 26417 79647404
Weight increased 38.98 10.31 121 70446 277265 79396556
Ejection fraction decreased 38.81 10.31 91 70476 34486 79639335
Tubulointerstitial nephritis 37.98 10.31 96 70471 38139 79635682
Mouth swelling 37.96 10.31 36 70531 6015 79667806
Tenderness 37.93 10.31 72 70495 23570 79650251
Alopecia 37.65 10.31 94 70473 231261 79442560
Haemorrhoids 37.54 10.31 81 70486 29047 79644774
Genital pain 37.46 10.31 17 70550 797 79673024
Blood urea increased 37.02 10.31 111 70456 48679 79625142
Pleuritic pain 36.50 10.31 45 70522 10107 79663714
Psoriatic arthropathy 36.05 10.31 12 70555 77987 79595834
Hepatitis 35.18 10.31 119 70448 55608 79618213
Suicide attempt 34.60 10.31 15 70552 82917 79590904
Hypophagia 34.22 10.31 103 70464 45264 79628557
Abdominal discomfort 34.08 10.31 111 70456 250616 79423205
Confusional state 33.88 10.31 430 70137 317567 79356254
Anal inflammation 33.74 10.31 19 70548 1411 79672410
Swollen tongue 33.39 10.31 98 70469 42472 79631349
Nasal congestion 33.30 10.31 13 70554 76539 79597282
Dialysis 33.11 10.31 59 70508 18403 79655418
Angioedema 32.89 10.31 144 70423 75891 79597930
Injection site erythema 32.85 10.31 14 70553 78183 79595638
Crepitations 32.21 10.31 42 70525 9975 79663846
Respiratory tract infection bacterial 31.99 10.31 21 70546 2056 79671765
Blood pressure systolic increased 31.50 10.31 10 70557 66976 79606845
Deafness transitory 31.28 10.31 16 70551 979 79672842
Rash pruritic 30.49 10.31 135 70432 71494 79602327
Jaundice 30.29 10.31 110 70457 53239 79620582
Rash erythematous 30.20 10.31 116 70451 57653 79616168
Deep vein thrombosis 29.69 10.31 196 70371 120723 79553098
Blood lactate dehydrogenase increased 29.61 10.31 89 70478 39081 79634740
Influenza 29.54 10.31 43 70524 129563 79544258
Bone marrow failure 29.54 10.31 106 70461 51001 79622820
Cushingoid 29.09 10.31 39 70528 9513 79664308
Deformity 28.92 10.31 39 70528 9566 79664255
Superinfection 28.56 10.31 28 70539 4874 79668947
Blood potassium increased 28.55 10.31 73 70494 29202 79644619
Cellulitis enterococcal 28.09 10.31 7 70560 46 79673775
Atelectasis 27.97 10.31 77 70490 32180 79641641
Meningoencephalitis herpetic 27.97 10.31 19 70548 1970 79671851
Blood alkaline phosphatase increased 27.86 10.31 121 70446 63543 79610278
Liver transplant rejection 27.71 10.31 23 70544 3225 79670596
Proctalgia 27.70 10.31 39 70528 9962 79663859
Oral pain 27.67 10.31 76 70491 31722 79642099
Intestinal intraepithelial lymphocytes increased 27.47 10.31 9 70558 171 79673650
Asthma 26.88 10.31 49 70518 135046 79538775
Hepatic cytolysis 26.78 10.31 68 70499 27083 79646738
Alanine aminotransferase increased 26.76 10.31 240 70327 162330 79511491
Clostridial infection 26.71 10.31 29 70538 5685 79668136
Blood culture positive 26.57 10.31 35 70532 8394 79665427
Haemoglobin decreased 26.53 10.31 307 70260 221812 79452009
SARS-CoV-2 test negative 26.48 10.31 16 70551 1355 79672466
Bronchopulmonary aspergillosis 26.48 10.31 60 70507 22234 79651587
Documented hypersensitivity to administered product 26.26 10.31 14 70553 933 79672888
Vulvovaginal candidiasis 26.15 10.31 20 70547 2494 79671327
Hospitalisation 25.97 10.31 27 70540 94209 79579612
Maternal exposure during pregnancy 25.87 10.31 51 70516 136487 79537334
Complications of transplanted kidney 25.81 10.31 30 70537 6336 79667485
Plasma cell myeloma 25.47 10.31 104 70463 53155 79620666
Mental status changes 25.39 10.31 122 70445 66837 79606984
Arthralgia 25.34 10.31 355 70212 571448 79102373
Liver transplant 25.28 10.31 25 70542 4398 79669423
Febrile bone marrow aplasia 25.16 10.31 43 70524 12977 79660844
Bacterial test positive 25.15 10.31 32 70535 7417 79666404
Vaginal discharge 25.11 10.31 32 70535 7431 79666390
Systemic lupus erythematosus 24.95 10.31 43 70524 121106 79552715
Liver function test increased 24.82 10.31 3 70564 39770 79634051
Infusion related reaction 24.79 10.31 112 70455 230125 79443696
Aspartate aminotransferase increased 24.54 10.31 208 70359 138433 79535388
Injection site pruritus 24.48 10.31 4 70563 42279 79631542
Loss of personal independence in daily activities 24.41 10.31 33 70534 102547 79571274
Aspergillus infection 24.37 10.31 53 70514 19108 79654713
Fluid retention 24.18 10.31 16 70551 69793 79604028
COVID-19 24.16 10.31 66 70501 157608 79516213
Dermatitis exfoliative 23.94 10.31 38 70529 10791 79663030
Blood bilirubin increased 23.91 10.31 119 70448 66113 79607708
Hepatosplenomegaly 23.61 10.31 28 70539 6041 79667780
Pseudomonas infection 23.44 10.31 55 70512 20848 79652973
Culture urine positive 23.39 10.31 24 70543 4411 79669410
Serum sickness 23.36 10.31 22 70545 3644 79670177
Rash morbilliform 23.31 10.31 28 70539 6122 79667699
Synovial cyst 23.19 10.31 36 70531 10029 79663792
Pulmonary embolism 23.13 10.31 243 70324 171411 79502410
Oral candidiasis 23.04 10.31 68 70499 29560 79644261
Cryptitis 23.04 10.31 9 70558 289 79673532
Feeling jittery 22.98 10.31 41 70526 12800 79661021
Pregnancy with injectable contraceptive 22.78 10.31 7 70560 107 79673714
Injection site reaction 22.71 10.31 10 70557 54775 79619046
Pain 22.41 10.31 464 70103 703338 78970483
Arthropathy 22.30 10.31 81 70486 177030 79496791
Injection site swelling 22.22 10.31 7 70560 47125 79626696
Toxic skin eruption 22.16 10.31 56 70511 22237 79651584
Renal tubular disorder 22.12 10.31 28 70539 6458 79667363
Overdose 22.06 10.31 86 70481 184120 79489701
Vomiting 21.85 10.31 756 69811 665072 79008749
Product use in unapproved indication 21.77 10.31 131 70436 250228 79423593
Microvillous inclusion disease 21.75 10.31 8 70559 217 79673604
Red blood cell sedimentation rate increased 21.35 10.31 7 70560 45935 79627886
Apoptosis 21.25 10.31 10 70557 510 79673311
Lung infiltration 21.18 10.31 56 70511 22856 79650965
Excessive eye blinking 20.99 10.31 15 70552 1686 79672135
Blood sodium decreased 20.97 10.31 71 70496 33184 79640637
Therapeutic response decreased 20.97 10.31 17 70550 66836 79606985
Graft versus host disease 20.77 10.31 43 70524 14983 79658838
Meningitis aseptic 20.66 10.31 28 70539 6900 79666921
Blood antidiuretic hormone increased 20.64 10.31 6 70561 75 79673746
White blood cell count decreased 20.62 10.31 256 70311 188032 79485789
Respiratory tract infection viral 20.59 10.31 22 70545 4237 79669584
Hepatomegaly 20.45 10.31 49 70518 18825 79654996
Probiotic therapy 20.45 10.31 7 70560 153 79673668
Rheumatoid arthritis 20.35 10.31 105 70462 208365 79465456
Leukaemia recurrent 20.32 10.31 18 70549 2756 79671065
Viral test positive 20.14 10.31 9 70558 407 79673414
Fibromyalgia 20.06 10.31 111 70456 64229 79609592
Parkinsonian rest tremor 20.02 10.31 8 70559 273 79673548
Neutropenic sepsis 19.99 10.31 61 70506 27003 79646818
Flank pain 19.89 10.31 50 70517 19794 79654027
Renal papillary necrosis 19.85 10.31 9 70558 421 79673400
Urinary tract infection 19.74 10.31 347 70220 274165 79399656
Rhinorrhoea 19.63 10.31 23 70544 76051 79597770
Stress 19.56 10.31 25 70542 79587 79594234
Aplasia pure red cell 19.51 10.31 29 70538 7781 79666040
Liver disorder 19.38 10.31 120 70447 72297 79601524
Acquired immunodeficiency syndrome 19.33 10.31 8 70559 299 79673522
Antinuclear antibody positive 19.28 10.31 29 70538 7861 79665960
Cataract 19.23 10.31 16 70551 62104 79611717
Palmar erythema 19.19 10.31 15 70552 1932 79671889
Refusal of treatment by patient 19.12 10.31 31 70536 8960 79664861
Trimethylaminuria 19.06 10.31 7 70560 189 79673632
Body mass index decreased 18.95 10.31 10 70557 653 79673168
Cardiogenic shock 18.43 10.31 7 70560 41907 79631914
Cholestasis 18.37 10.31 93 70474 52016 79621805
Thrombotic microangiopathy 18.34 10.31 49 70518 20120 79653701
Gastrointestinal pain 18.33 10.31 32 70535 9823 79663998
Cytomegalovirus test 18.21 10.31 5 70562 50 79673771
Chronic lymphocytic leukaemia 18.19 10.31 22 70545 4844 79668977
Hepatitis fulminant 18.19 10.31 27 70540 7235 79666586
Pulmonary toxicity 17.90 10.31 37 70530 12877 79660944
Chronic obstructive pulmonary disease 17.88 10.31 30 70537 85389 79588432
Clostridium difficile infection 17.82 10.31 80 70487 42605 79631216
Colour blindness acquired 17.80 10.31 6 70561 125 79673696
Chronic sinusitis 17.68 10.31 37 70530 12989 79660832
Clostridium test positive 17.63 10.31 25 70542 6429 79667392
Ocular hyperaemia 17.59 10.31 60 70507 28146 79645675
Seizure 17.46 10.31 249 70318 188585 79485236
Foaming at mouth 17.37 10.31 14 70553 1883 79671938
Enterococcal infection 17.34 10.31 41 70526 15619 79658202
Erythema multiforme 17.19 10.31 44 70523 17607 79656214
Treatment failure 17.13 10.31 85 70482 170401 79503420
Biliary sepsis 17.12 10.31 13 70554 1604 79672217
Mucosal inflammation 17.05 10.31 120 70447 75460 79598361
Paraesthesia oral 16.90 10.31 48 70519 20423 79653398
Culture stool positive 16.71 10.31 9 70558 612 79673209
Lymphocele 16.67 10.31 13 70554 1668 79672153
Autoimmune haemolytic anaemia 16.62 10.31 28 70539 8352 79665469
HIV wasting syndrome 16.61 10.31 5 70562 71 79673750
Blood pressure fluctuation 16.59 10.31 21 70546 67124 79606697
Angiodermatitis 16.42 10.31 5 70562 74 79673747
Macular degeneration 16.41 10.31 33 70534 11263 79662558
HIV infection 16.41 10.31 11 70556 1116 79672705
Renal tubular acidosis 16.30 10.31 18 70549 3596 79670225
Osteonecrosis of jaw 16.24 10.31 9 70558 43217 79630604
Biopsy liver abnormal 16.20 10.31 8 70559 454 79673367
Antinuclear antibody 16.12 10.31 8 70559 459 79673362
Sinusitis 16.11 10.31 104 70463 195397 79478424
Rash macular 15.91 10.31 59 70508 28840 79644981
Dehydration 15.84 10.31 308 70259 247879 79425942
Pemphigus 15.77 10.31 41 70526 99541 79574280
Orbital haemorrhage 15.71 10.31 4 70563 29 79673792
Cholecystitis chronic 15.68 10.31 30 70537 9876 79663945
Inappropriate antidiuretic hormone secretion 15.57 10.31 55 70512 26258 79647563
Memory impairment 15.49 10.31 49 70518 111685 79562136
Effusion 15.49 10.31 14 70553 2200 79671621
Rectal haemorrhage 15.41 10.31 118 70449 76182 79597639
Eye pain 15.37 10.31 70 70497 37508 79636313
Abdominal pain 15.27 10.31 452 70115 389117 79284704
Blindness cortical 15.25 10.31 10 70557 977 79672844
Purpura senile 15.16 10.31 8 70559 522 79673299
Myocardial infarction 15.15 10.31 98 70469 184031 79489790
Vena cava injury 15.10 10.31 7 70560 345 79673476
Tarsal tunnel syndrome 15.08 10.31 8 70559 528 79673293
Complications of transplant surgery 15.05 10.31 9 70558 748 79673073
Chemotherapeutic drug level increased 15.00 10.31 7 70560 350 79673471
Granulomatous rosacea 14.87 10.31 6 70561 210 79673611
Erythema infectiosum 14.84 10.31 6 70561 211 79673610
Bone density decreased 14.84 10.31 35 70532 13312 79660509
Blood bilirubin unconjugated increased 14.80 10.31 10 70557 1027 79672794
Synovial disorder 14.79 10.31 13 70554 1970 79671851
Drug interaction 14.75 10.31 476 70091 414707 79259114
Cystitis noninfective 14.69 10.31 11 70556 1329 79672492
Drug dependence 14.59 10.31 9 70558 40760 79633061
Pain in extremity 14.50 10.31 231 70336 364307 79309514
Rheumatoid factor positive 14.49 10.31 19 70548 59820 79614001
Cardiac failure congestive 14.30 10.31 71 70496 142331 79531490
Pericarditis 14.25 10.31 46 70521 104190 79569631
Accidental exposure to product 14.16 10.31 5 70562 31317 79642504
Neuropathy peripheral 14.15 10.31 189 70378 141116 79532705
Unevaluable event 14.13 10.31 17 70550 55568 79618253
Lymphopenia 14.08 10.31 59 70508 30498 79643323
Hepatitis cholestatic 13.98 10.31 35 70532 13817 79660004
Myositis 13.97 10.31 43 70524 19125 79654696
Glossodynia 13.85 10.31 46 70521 103291 79570530
Therapy cessation 13.85 10.31 8 70559 37554 79636267
Device expulsion 13.79 10.31 3 70564 25858 79647963
Gastric disorder 13.76 10.31 8 70559 37425 79636396
Hepatic failure 13.70 10.31 97 70470 61115 79612706
Vaginal flatulence 13.70 10.31 14 70553 2561 79671260
Wound evisceration 13.68 10.31 5 70562 133 79673688
SARS-CoV-2 antibody test positive 13.63 10.31 7 70560 432 79673389
Limb discomfort 13.61 10.31 6 70561 32844 79640977
Soft tissue swelling 13.58 10.31 11 70556 1490 79672331
Malaise 13.57 10.31 546 70021 489323 79184498
Purpura 13.49 10.31 43 70524 19484 79654337
Pseudomembranous colitis 13.49 10.31 20 70547 5354 79668467
Gait disturbance 13.48 10.31 118 70449 207388 79466433
Proctitis 13.44 10.31 22 70545 6410 79667411
Lung transplant rejection 13.39 10.31 11 70556 1520 79672301
Vaginal ulceration 13.39 10.31 6 70561 273 79673548
Tenosynovitis 13.36 10.31 37 70530 15517 79658304
Cytomegalovirus test positive 13.33 10.31 21 70546 5926 79667895
Intentional self-injury 13.30 10.31 6 70561 32413 79641408
Autonomic neuropathy 13.29 10.31 12 70555 1883 79671938
Osteoporosis 13.29 10.31 17 70550 54095 79619726
Lymphocytic infiltration 13.26 10.31 11 70556 1542 79672279
Pneumonia cytomegaloviral 13.21 10.31 19 70548 4950 79668871
Bacterial sepsis 13.19 10.31 25 70542 8173 79665648
Muscle twitching 13.16 10.31 50 70517 24714 79649107
Hepatic enzyme increased 13.15 10.31 101 70466 182509 79491312
Abdominal wall haemorrhage 13.15 10.31 8 70559 686 79673135
Potentiating drug interaction 13.10 10.31 26 70541 8793 79665028
Enterovirus infection 13.01 10.31 12 70555 1935 79671886
Discomfort 12.98 10.31 62 70505 125555 79548266
Condition aggravated 12.94 10.31 341 70226 500783 79173038
Acne 12.89 10.31 4 70563 27186 79646635
Cushing's syndrome 12.80 10.31 9 70558 986 79672835
Body temperature increased 12.77 10.31 75 70492 44345 79629476
Joint effusion 12.75 10.31 40 70527 17974 79655847
Adverse event 12.74 10.31 21 70546 60193 79613628
Heart rate decreased 12.69 10.31 27 70540 70289 79603532
Eosinophilia 12.68 10.31 76 70491 45269 79628552
Dermatitis allergic 12.59 10.31 40 70527 18090 79655731
Febrile neutropenia 12.55 10.31 280 70287 230719 79443102
Genital burning sensation 12.46 10.31 6 70561 322 79673499
Tumour lysis syndrome 12.45 10.31 48 70519 23891 79649930
Prurigo 12.32 10.31 10 70557 1359 79672462
Osteoarthritis 12.31 10.31 38 70529 87271 79586550
Infection 12.21 10.31 290 70277 241422 79432399
Wound 12.20 10.31 57 70510 116122 79557699
Petechiae 12.18 10.31 43 70524 20522 79653299
Hepatitis C virus test 12.16 10.31 4 70563 77 79673744
Surgery 12.05 10.31 7 70560 32759 79641062
Flatulence 12.04 10.31 12 70555 42712 79631109
Sedation 12.04 10.31 17 70550 51878 79621943
Renal transplant 12.04 10.31 13 70554 2534 79671287
Limb reduction defect 11.92 10.31 4 70563 82 79673739
Lung neoplasm 11.92 10.31 22 70545 7047 79666774
Contraindicated product administered 11.89 10.31 86 70481 157452 79516369
Human herpesvirus 6 infection reactivation 11.86 10.31 7 70560 568 79673253
Anti-cyclic citrullinated peptide antibody positive 11.85 10.31 36 70531 83107 79590714
Tumour flare 11.83 10.31 9 70558 1114 79672707
Culture positive 11.80 10.31 9 70558 1117 79672704
Perinephric collection 11.79 10.31 6 70561 363 79673458
Sleep apnoea syndrome 11.79 10.31 9 70558 36469 79637352
Staphylococcal infection 11.69 10.31 90 70477 58205 79615616
Acute graft versus host disease 11.67 10.31 27 70540 10140 79663681
Hydronephrosis 11.66 10.31 38 70529 17416 79656405
Areflexia 11.66 10.31 19 70548 5515 79668306
Suicidal ideation 11.65 10.31 32 70535 76308 79597513
Idiopathic pneumonia syndrome 11.63 10.31 7 70560 589 79673232
Acute graft versus host disease in intestine 11.55 10.31 16 70551 4025 79669796
Cardio-respiratory arrest 11.54 10.31 53 70514 108457 79565364
Cholelithiasis 11.52 10.31 83 70484 52581 79621240
Immunosuppressant drug level increased 11.51 10.31 25 70542 9002 79664819
Product quality issue 11.45 10.31 8 70559 33932 79639889
Haematocrit decreased 11.38 10.31 93 70474 61219 79612602
Altered visual depth perception 11.38 10.31 6 70561 391 79673430
Hypovolaemia 11.36 10.31 38 70529 17653 79656168
Limb injury 11.31 10.31 6 70561 29522 79644299
Escherichia test positive 11.30 10.31 14 70553 3161 79670660
Blood chloride increased 11.27 10.31 18 70549 5138 79668683
Syncope 11.23 10.31 103 70464 179346 79494475
Lip ulceration 11.22 10.31 12 70555 2313 79671508
Drug hypersensitivity 11.21 10.31 345 70222 298571 79375250
Haemolytic anaemia 11.20 10.31 38 70529 17782 79656039
Loss of consciousness 11.13 10.31 95 70472 167848 79505973
Glioblastoma multiforme 11.11 10.31 9 70558 1219 79672602
Prostatitis 11.07 10.31 16 70551 4186 79669635
Cerebral toxoplasmosis 11.06 10.31 12 70555 2350 79671471
Motion sickness 11.06 10.31 8 70559 917 79672904
Multiple sclerosis relapse 11.04 10.31 15 70552 46518 79627303
Migraine 11.02 10.31 40 70527 87453 79586368
No adverse event 11.00 10.31 10 70557 37182 79636639
Pneumonia fungal 10.98 10.31 28 70539 11182 79662639
Nail infection 10.91 10.31 12 70555 2387 79671434
Food poisoning 10.91 10.31 17 70550 4752 79669069
Parkinsonism hyperpyrexia syndrome 10.85 10.31 5 70562 243 79673578
Hot flush 10.83 10.31 20 70547 54857 79618964
Hepatitis B antibody positive 10.82 10.31 4 70563 110 79673711
Hepatitis A antibody positive 10.79 10.31 4 70563 111 79673710
Apraxia 10.78 10.31 13 70554 2854 79670967
Pustule 10.75 10.31 11 70556 2014 79671807
Impaired work ability 10.68 10.31 40 70527 19641 79654180
Renal cyst haemorrhage 10.67 10.31 7 70560 685 79673136
Herpes simplex viraemia 10.66 10.31 6 70561 445 79673376
Candida infection 10.65 10.31 64 70503 38150 79635671
Drug intolerance 10.62 10.31 167 70400 263952 79409869
Chills 10.61 10.31 200 70367 160034 79513787
Acute febrile neutrophilic dermatosis 10.58 10.31 15 70552 3857 79669964
Suprapubic pain 10.56 10.31 8 70559 984 79672837
Tooth disorder 10.54 10.31 5 70562 26228 79647593
Pulmonary arterial hypertension 10.52 10.31 6 70561 28360 79645461
Bronchitis 10.50 10.31 70 70497 130574 79543247
Herpes simplex 10.47 10.31 29 70538 12158 79661663
Erosive duodenitis 10.35 10.31 11 70556 2106 79671715
Proteus infection 10.34 10.31 11 70556 2107 79671714

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Trimethoprim and derivatives
ATC J01EE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA EPC N0000175489 Dihydrofolate Reductase Inhibitor Antibacterial
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065687 Cytochrome P-450 CYP2C8 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50683 dihydrofolic acid reductase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Haemophilus Influenzae Acute Otitis Media indication 19021002
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Bacterial conjunctivitis indication 128350005 DOID:9700
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Acute exacerbation of chronic bronchitis indication 425748003
Morganella Morganii Urinary Tract Infection indication
Staphylococcus Aureus Urinary Tract Infection indication
Pneumocystis Carinii Pneumonia Prevention indication
Haemophilus Influenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Typhoid fever off-label use 4834000 DOID:13258
Infection of skin AND/OR subcutaneous tissue off-label use 19824006
Pertussis off-label use 27836007
Granuloma inguinale off-label use 28867007 DOID:9113
Nocardiosis off-label use 29227009 DOID:2312
Listeria meningitis off-label use 31568009 DOID:11572
Sinusitis off-label use 36971009
Whipple's disease off-label use 41545003 DOID:8476
Bacterial pneumonia off-label use 53084003 DOID:874
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Cholera off-label use 63650001 DOID:1498
Brucellosis off-label use 75702008 DOID:11077
Paratyphoid fever off-label use 85904008 DOID:3055
Chlamydial infection off-label use 105629000
Infection of bone off-label use 111253001
Meningococcus carrier off-label use 170486006
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Chancroid off-label use 266143009 DOID:13778
Diverticulitis of gastrointestinal tract off-label use 271366000
Bacterial endocarditis off-label use 301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Toxoplasmosis Prevention off-label use
Postexposure Plague Prophylaxis off-label use
Chronic Bacterial Prostatitis off-label use
Diabetic Foot Infection off-label use
Third trimester pregnancy contraindication 41587001
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Folic acid deficiency contraindication 190633005
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Dogs Systemic antibacterial action against sensitive organisms to surgery Indication
Dogs Systemic antibacterial action against sensitive organisms to debridement Indication
Dogs Control of bacterial infection during the treatment of acute urinary tract infections Indication
Dogs Control of bacterial infection during the treatment of acute bacterial complications of distemper Indication
Dogs Control of bacterial infection during the treatment of acute respiratory tract infections Indication
Dogs Control of bacterial infection during the treatment of acute alimentary tract infections Indication
Dogs Control of bacterial infection during the treatment of wound infections Indication
Dogs Control of bacterial infection during the treatment of abscesses Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of acute strangles Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of respiratory tract infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of acute urogenital infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of wound infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of abscesses Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Tribrissen 120 Tablets, Tribrissen 30 Tablets, Tribrissen 480 Tablets, Tribrissen 960 Tablets Intervet Inc. 2
Tribrissen 24% Injection Intervet Inc. 2
Tribrissen 48% Injection Intervet Inc. 2
Di-Trim Tablets Zoetis Inc. 2
Tribrissen 400 Oral Paste Intervet Inc. 2
Di-Trim 24% Zoetis Inc. 2
Di-Trim 48% Injection Zoetis Inc. 2
Di-Trim 400 Paste Zoetis Inc. 2
Tribrissen 60 Oral Suspension Intervet Inc. 2
EQUISUL-SDT Aurora Pharmaceutical Inc. 2
Uniprim Powder Neogen Corp. 2
Tucoprim Powder Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 0.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme Ki 8 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.25 CHEMBL
Dihydrofolate reductase Enzyme INHIBITOR IC50 5.57 CHEMBL CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.82 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 6.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 7.99 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.30 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.84 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.88 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6.92 WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 8.66 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.72 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 8.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 8 WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.06 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.62 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 5.40 CHEMBL
Dihydrofolate reductase type 1 Enzyme IC50 6.30 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.38 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.04 CHEMBL

External reference:

IDSource
4017735 VUID
N0000146103 NUI
D00145 KEGG_DRUG
56585-33-2 SECONDARY_CAS_RN
60834-30-2 SECONDARY_CAS_RN
4017735 VANDF
4019528 VANDF
C0041041 UMLSCUI
CHEBI:45924 CHEBI
TOP PDB_CHEM_ID
CHEMBL22 ChEMBL_ID
DB00440 DRUGBANK_ID
CHEMBL2110367 ChEMBL_ID
CHEMBL1201080 ChEMBL_ID
D014295 MESH_DESCRIPTOR_UI
5578 PUBCHEM_CID
10931 IUPHAR_LIGAND_ID
1047 INN_ID
AN164J8Y0X UNII
10829 RXNORM
3055 MMSL
5633 MMSL
5634 MMSL
d00123 MMSL
002873 NDDF
008281 NDDF
32792001 SNOMEDCT_US
387179001 SNOMEDCT_US
412323009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 19 sections
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 19 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-0853 SUSPENSION 40 mg ORAL NDA 28 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 40 mg ORAL NDA 29 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 40 mg ORAL NDA 29 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-4793 SUSPENSION 40 mg ORAL ANDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0440-2406 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-8121 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0904-2725 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-053 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-092 TABLET 160 mg ORAL ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-525 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-926 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-940 TABLET 160 mg ORAL ANDA 27 sections