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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	2585	846-50-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: temazepam (RS)-Temazepam levanxene levanxol	A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. Molecular weight: 300.74 Formula: C16H13ClN2O2 CLOGP: 2.34 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 52.90 ALOGS: -3.75 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

temazepam
(RS)-Temazepam
levanxene
levanxol

A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Molecular weight: 300.74
Formula: C16H13ClN2O2
CLOGP: 2.34
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 52.90
ALOGS: -3.75
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
20	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.60 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	96 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4,PRKDC	9
kinase-selectivity-class	AXL,GRK2	2
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Feb. 27, 1981	FDA	MALLINCKRODT INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Food allergy	723.06	9.85	363	68141	25115	90534828
Temperature regulation disorder	643.86	9.85	282	68222	14297	90545646
Completed suicide	618.60	9.85	650	67854	144408	90415535
Immunodeficiency	576.05	9.85	376	68128	42858	90517085
Overdose	523.33	9.85	620	67884	157089	90402854
Hyperhidrosis	463.96	9.85	543	67961	135762	90424181
Toxicity to various agents	457.79	9.85	797	67707	287049	90272894
Rash erythematous	398.36	9.85	356	68148	64748	90495195
Foetal death	307.58	9.85	193	68311	20530	90539413
Coeliac disease	303.13	9.85	259	68245	44351	90515592
Fluid retention	284.76	9.85	342	68162	87749	90472194
Intentional product misuse	275.22	9.85	339	68165	89265	90470678
Upper respiratory tract infection	248.92	9.85	389	68115	127929	90432014
Prescribed overdose	213.48	9.85	313	68191	97312	90462631
Pemphigus	212.05	9.85	8	68496	326856	90233087
Back pain	194.81	9.85	604	67900	316571	90243372
Hand deformity	177.22	9.85	12	68492	296350	90263593
Glossodynia	159.44	9.85	26	68478	321753	90238190
Constipation	159.34	9.85	520	67984	279875	90280068
Asthma	158.76	9.85	472	68032	241688	90318255
Wound	153.47	9.85	23	68481	302957	90256986
Pericarditis	150.30	9.85	15	68489	270136	90289807
Systemic lupus erythematosus	147.72	9.85	45	68459	361851	90198092
Anti-cyclic citrullinated peptide antibody positive	146.08	9.85	8	68496	236425	90323518
Respiratory arrest	125.46	9.85	140	68364	33171	90526772
Duodenal ulcer perforation	123.83	9.85	12	68492	221276	90338667
Synovitis	120.84	9.85	49	68455	329703	90230240
Folliculitis	117.25	9.85	10	68494	204343	90355600
Psoriasis	116.41	9.85	308	68196	147446	90412497
Discomfort	110.31	9.85	35	68469	274300	90285643
Maternal exposure during pregnancy	110.16	9.85	68	68436	359995	90199948
Arthropathy	99.06	9.85	79	68425	366163	90193780
Rheumatoid factor positive	96.84	9.85	9	68495	171641	90388302
Bursitis	96.23	9.85	267	68237	131387	90428556
Swelling	96.15	9.85	105	68399	418953	90140990
Rheumatic fever	89.19	9.85	7	68497	153114	90406829
Liver injury	88.54	9.85	12	68492	170555	90389388
Abdominal discomfort	83.05	9.85	146	68358	477182	90082761
Blister	82.45	9.85	45	68459	254953	90304990
Libido increased	81.09	9.85	35	68469	1709	90558234
Poisoning	79.04	9.85	76	68428	15141	90544802
Irritable bowel syndrome	78.98	9.85	29	68475	207419	90352524
Drug abuse	78.87	9.85	185	68319	82162	90477781
Myocardial depression	78.36	9.85	26	68478	607	90559336
Ill-defined disorder	75.35	9.85	23	68481	184868	90375075
Hostility	75.25	9.85	36	68468	2237	90557706
Cardiac arrest	74.89	9.85	211	68293	104724	90455219
Exposure during pregnancy	73.78	9.85	366	68138	238044	90321899
Therapeutic product effect decreased	73.62	9.85	61	68443	277510	90282433
Muscle injury	71.95	9.85	22	68482	176632	90383311
Decorticate posture	71.43	9.85	21	68483	324	90559619
Gastrointestinal disorder	71.10	9.85	54	68450	256633	90303310
Carbuncle	70.67	9.85	30	68474	1406	90558537
Drug ineffective	69.58	9.85	691	67813	1383607	89176336
Peripheral swelling	68.58	9.85	130	68374	412976	90146967
Cardio-respiratory arrest	68.43	9.85	149	68355	62991	90496952
Alopecia	68.04	9.85	173	68331	494898	90065045
C-reactive protein abnormal	66.04	9.85	9	68495	127420	90432523
Accidental overdose	65.17	9.85	93	68411	28180	90531763
Intentional product use issue	64.86	9.85	42	68462	216850	90343093
Polyp	63.69	9.85	50	68454	7594	90552349
Thrombocytopenia	63.55	9.85	319	68185	208406	90351537
Post-traumatic neck syndrome	63.11	9.85	33	68471	2481	90557462
Soft tissue injury	62.84	9.85	31	68473	2061	90557882
Impaired healing	62.67	9.85	51	68453	234148	90325795
Hypertension	62.53	9.85	573	67931	456959	90102984
Substance abuse	62.30	9.85	43	68461	5363	90554580
General physical health deterioration	62.29	9.85	108	68396	355007	90204936
Swollen joint count increased	62.26	9.85	6	68498	111200	90448743
Decreased immune responsiveness	61.87	9.85	52	68452	8696	90551247
Sternal fracture	61.55	9.85	34	68470	2853	90557090
Hepatic enzyme increased	59.40	9.85	471	68033	360265	90199678
Erythema	57.99	9.85	333	68171	228913	90331030
Therapeutic product effect incomplete	57.35	9.85	38	68466	193858	90366085
Victim of sexual abuse	56.98	9.85	21	68483	674	90559269
Respiratory depression	54.47	9.85	63	68441	15512	90544431
Wheezing	54.16	9.85	60	68444	238020	90321923
Psoriatic arthropathy	53.66	9.85	56	68448	228279	90331664
Headache	52.44	9.85	929	67575	861817	89698126
Dyslipidaemia	51.59	9.85	50	68454	10057	90549886
Rectal polyp	50.65	9.85	22	68482	1091	90558852
Lip dry	50.30	9.85	8	68496	100947	90458996
Overweight	49.84	9.85	39	68465	5895	90554048
Helicobacter infection	49.62	9.85	59	68445	226791	90333152
Nasopharyngitis	49.40	9.85	151	68353	406953	90152990
Stomatitis	48.64	9.85	83	68421	274615	90285328
Judgement impaired	48.63	9.85	20	68484	865	90559078
Arteriosclerosis coronary artery	48.06	9.85	47	68457	9556	90550387
Lung disorder	47.63	9.85	27	68477	149856	90410087
Fibrosis	47.59	9.85	38	68466	5914	90554029
Hypothalamo-pituitary disorder	46.59	9.85	26	68478	2226	90557717
Product use issue	46.46	9.85	416	68088	329503	90230440
Facet joint syndrome	46.40	9.85	9	68495	98380	90461563
Change of bowel habit	46.26	9.85	26	68478	2257	90557686
Urticaria	45.50	9.85	106	68398	312628	90247315
Intentional overdose	45.30	9.85	165	68339	93669	90466274
Monoclonal immunoglobulin present	45.25	9.85	25	68479	2099	90557844
Venous pressure jugular increased	45.06	9.85	17	68487	583	90559360
Suicidal ideation	44.60	9.85	140	68364	73715	90486228
Somnolence	44.21	9.85	290	68214	208794	90351149
Rheumatoid arthritis	43.99	9.85	443	68061	362171	90197772
Diabetes mellitus	43.89	9.85	128	68376	64747	90495196
Breast cancer stage III	43.67	9.85	6	68498	84441	90475502
Mobility decreased	43.26	9.85	77	68427	250657	90309286
Amblyopia	42.98	9.85	14	68490	308	90559635
Arthralgia	41.72	9.85	382	68122	778140	89781803
Condition aggravated	41.36	9.85	272	68232	595273	89964670
Duodenal ulcer	40.96	9.85	43	68461	9509	90550434
Coma scale abnormal	40.94	9.85	34	68470	5592	90554351
Nephropathy	40.36	9.85	42	68462	9193	90550750
Wound infection	40.27	9.85	15	68489	106387	90453556
Drug withdrawal syndrome	39.71	9.85	75	68429	28648	90531295
Musculoskeletal stiffness	38.12	9.85	107	68397	296425	90263518
Live birth	37.80	9.85	7	68497	79100	90480843
Inflammation	37.42	9.85	48	68456	178544	90381399
Night sweats	37.05	9.85	26	68478	128740	90431203
Grip strength decreased	36.84	9.85	12	68492	92564	90467379
Nightmare	36.81	9.85	62	68442	21663	90538280
Product use in unapproved indication	36.45	9.85	131	68373	336105	90223838
Tremor	36.44	9.85	219	68285	152954	90406989
Lower respiratory tract infection	36.41	9.85	85	68419	250574	90309369
Rectal prolapse	35.87	9.85	22	68482	2245	90557698
Mass	35.55	9.85	51	68453	15526	90544417
Wrist deformity	35.55	9.85	25	68479	3213	90556730
Urine odour abnormal	35.41	9.85	35	68469	7209	90552734
Irritability	35.10	9.85	81	68423	35581	90524362
Peripheral venous disease	34.98	9.85	10	68494	83911	90476032
Intestinal haemorrhage	34.72	9.85	28	68476	4419	90555524
Type 2 diabetes mellitus	34.53	9.85	63	68441	203181	90356762
Transplant dysfunction	34.50	9.85	30	68474	5252	90554691
Hypothermia	34.10	9.85	50	68454	15525	90544418
Infected dermal cyst	33.71	9.85	13	68491	474	90559469
Obesity	33.52	9.85	19	68485	105488	90454455
Kyphosis	33.20	9.85	23	68481	2885	90557058
Fibromyalgia	32.38	9.85	67	68437	206202	90353741
Poor quality sleep	32.32	9.85	63	68441	24630	90535313
Neutropenia	32.08	9.85	77	68427	224827	90335116
Sensitisation	31.99	9.85	26	68478	4149	90555794
Abdominal pain upper	31.97	9.85	136	68368	332538	90227405
Injury	31.92	9.85	63	68441	197286	90362657
Toxicologic test abnormal	31.79	9.85	14	68490	718	90559225
Dehydration	31.47	9.85	253	68251	194194	90365749
Frustration tolerance decreased	31.13	9.85	34	68470	7862	90552081
Impaired reasoning	30.78	9.85	9	68495	136	90559807
Pulmonary fibrosis	30.54	9.85	22	68482	107481	90452462
Deep vein thrombosis postoperative	30.33	9.85	8	68496	70801	90489142
Accidental death	30.19	9.85	19	68485	2029	90557914
C-reactive protein increased	30.13	9.85	57	68447	181332	90378611
Hepatic steatosis	30.06	9.85	78	68426	36867	90523076
Sinusitis	29.55	9.85	146	68358	342942	90217001
Withdrawal syndrome	28.91	9.85	57	68447	22467	90537476
Autoimmune disorder	28.74	9.85	11	68493	76733	90483210
Abnormal behaviour	28.73	9.85	57	68447	22571	90537372
Unresponsive to stimuli	28.51	9.85	78	68426	38043	90521900
Somnambulism	28.44	9.85	29	68475	6199	90553744
Proctalgia	28.39	9.85	33	68471	8165	90551778
Gait inability	28.03	9.85	42	68462	146414	90413529
Postmortem blood drug level	27.99	9.85	8	68496	111	90559832
Apnoea	27.88	9.85	35	68469	9379	90550564
Miosis	27.67	9.85	35	68469	9449	90550494
Pruritus	27.54	9.85	269	68235	541256	90018687
Thiopurine methyltransferase decreased	27.37	9.85	10	68494	313	90559630
Hypercholesterolaemia	26.94	9.85	22	68482	100870	90459073
Band neutrophil percentage increased	26.81	9.85	9	68495	218	90559725
Anxiety	26.58	9.85	354	68150	309418	90250525
Knee arthroplasty	26.40	9.85	15	68489	83167	90476776
Mental disorder	26.06	9.85	68	68436	32250	90527693
Blood cholesterol increased	26.03	9.85	76	68428	207936	90352007
Injection site discomfort	25.93	9.85	27	68477	5913	90554030
Body height decreased	25.64	9.85	38	68466	11911	90548032
Furuncle	25.46	9.85	30	68474	7531	90552412
Movement disorder	25.42	9.85	63	68441	28956	90530987
Retching	25.22	9.85	49	68455	19110	90540833
Adjustment disorder with depressed mood	25.11	9.85	6	68498	56747	90503196
Off label use	24.90	9.85	639	67865	1101613	89458330
Dislocation of vertebra	24.60	9.85	6	68498	55962	90503981
Musculoskeletal discomfort	24.42	9.85	51	68453	20940	90539003
Blepharospasm	24.26	9.85	6	68498	55439	90504504
Myelocyte percentage increased	24.10	9.85	8	68496	187	90559756
Cardiac failure congestive	24.04	9.85	142	68362	98552	90461391
Drug dependence	23.95	9.85	62	68442	29265	90530678
Panic attack	23.90	9.85	58	68446	26307	90533636
Homicide	23.82	9.85	9	68495	310	90559633
Hip arthroplasty	23.81	9.85	14	68490	76194	90483749
Mental impairment	23.53	9.85	44	68460	16676	90543267
Concussion	23.41	9.85	35	68469	11056	90548887
Lower limb fracture	23.37	9.85	18	68486	84995	90474948
Antidepressant drug level above therapeutic	23.33	9.85	10	68494	480	90559463
Urine abnormality	23.29	9.85	29	68475	7708	90552235
Upper respiratory tract congestion	23.10	9.85	17	68487	2345	90557598
Personality disorder	23.09	9.85	37	68467	12407	90547536
Stress	23.07	9.85	122	68382	81273	90478670
Bundle branch block left	22.85	9.85	29	68475	7856	90552087
Bladder disorder	22.74	9.85	34	68470	10738	90549205
Rib fracture	22.74	9.85	57	68447	26378	90533565
Bone erosion	22.69	9.85	6	68498	53015	90506928
Peripheral coldness	22.68	9.85	39	68465	13853	90546090
Interstitial lung disease	22.54	9.85	15	68489	76390	90483553
Substance use	22.53	9.85	13	68491	1186	90558757
Urine oxalate increased	22.41	9.85	8	68496	234	90559709
Red blood cell sedimentation rate increased	22.06	9.85	18	68486	82577	90477366
Renal cyst	21.99	9.85	37	68467	12913	90547030
Epilepsy	21.85	9.85	18	68486	82188	90477755
Band neutrophil count increased	21.65	9.85	9	68495	400	90559543
Myelocyte count increased	21.50	9.85	9	68495	407	90559536
Analgesic drug level above therapeutic	21.28	9.85	7	68497	159	90559784
Suspected product quality issue	21.18	9.85	9	68495	423	90559520
Dry mouth	21.08	9.85	70	68434	183989	90375954
Ventricular hypokinesia	21.06	9.85	23	68481	5318	90554625
Middle insomnia	21.03	9.85	42	68462	16709	90543234
Device expulsion	20.91	9.85	3	68501	40883	90519060
Piloerection	20.68	9.85	10	68494	636	90559307
Urinary incontinence	20.67	9.85	69	68435	37497	90522446
Blood glucose decreased	20.66	9.85	51	68453	23378	90536565
Retinal depigmentation	20.50	9.85	8	68496	301	90559642
Haemorrhoids	20.33	9.85	55	68449	26647	90533296
Drug-induced liver injury	20.26	9.85	23	68481	90295	90469648
Dysgeusia	20.16	9.85	86	68418	52474	90507469
Therapy non-responder	20.13	9.85	46	68458	136658	90423285
Nail disorder	19.69	9.85	10	68494	59057	90500886
Accidental poisoning	19.63	9.85	11	68493	949	90558994
Hyperthermia	19.54	9.85	31	68473	10304	90549639
Transient global amnesia	19.51	9.85	10	68494	721	90559222
Rebound psychosis	19.25	9.85	7	68497	216	90559727
Prescribed underdose	19.24	9.85	17	68487	75002	90484941
Death	18.87	9.85	465	68039	456086	90103857
Oesophagitis ulcerative	18.48	9.85	10	68494	806	90559137
Bipolar I disorder	18.17	9.85	14	68490	2068	90557875
COVID-19	18.13	9.85	66	68438	168777	90391166
Forced vital capacity abnormal	17.87	9.85	5	68499	64	90559879
Homicidal ideation	17.83	9.85	13	68491	1767	90558176
Ovarian cyst	17.78	9.85	40	68464	17278	90542665
Fall	17.38	9.85	482	68022	481328	90078615
Gallbladder disorder	17.35	9.85	43	68461	19760	90540183
Premature delivery	17.34	9.85	4	68500	38758	90521185
Pulmonary congestion	16.82	9.85	42	68462	19391	90540552
Hypovolaemia	16.61	9.85	32	68472	12399	90547544
Onychomadesis	16.56	9.85	7	68497	45991	90513952
Restlessness	16.55	9.85	62	68442	35658	90524285
Dystrophic calcification	16.42	9.85	6	68498	188	90559755
Haemorrhage	16.37	9.85	99	68405	69270	90490673
Dysuria	16.31	9.85	66	68438	39335	90520608
X-ray abnormal	16.21	9.85	7	68497	45417	90514526
Purpura	16.15	9.85	35	68469	14743	90545200
Mood swings	16.12	9.85	43	68461	20659	90539284
Sleep disorder due to general medical condition, insomnia type	16.11	9.85	47	68457	128647	90431296
Sleep disorder	16.06	9.85	86	68418	197944	90361999
Lupus vulgaris	15.99	9.85	7	68497	45052	90514891
Thyroid disorder	15.99	9.85	39	68465	17746	90542197
Joint range of motion decreased	15.93	9.85	51	68453	135592	90424351
Hypersensitivity	15.88	9.85	453	68051	454224	90105719
Taste disorder	15.72	9.85	14	68490	61532	90498411
Muscle twitching	15.65	9.85	47	68457	24155	90535788
Respiratory alkalosis	15.64	9.85	16	68488	3432	90556511
Bacterial test	15.43	9.85	10	68494	1123	90558820
Abortion spontaneous	15.43	9.85	11	68493	54045	90505898
Loss of consciousness	15.40	9.85	168	68336	140070	90419873
Renal failure	15.34	9.85	159	68345	130848	90429095
Calculus urethral	15.27	9.85	3	68501	6	90559937
Injection site reaction	15.22	9.85	29	68475	92051	90467892
Potentiating drug interaction	15.12	9.85	20	68484	5642	90554301
Breast cancer stage II	15.12	9.85	4	68500	35330	90524613
Macular degeneration	14.97	9.85	5	68499	37965	90521978
Postoperative wound infection	14.90	9.85	32	68472	13394	90546549
Monocyte percentage increased	14.85	9.85	10	68494	1198	90558745
Pregnancy	14.81	9.85	15	68489	62032	90497911
Injection site erythema	14.62	9.85	33	68471	98469	90461474
Arteriosclerosis	14.58	9.85	28	68476	10825	90549118
No adverse event	14.51	9.85	18	68486	67964	90491979
Suspected suicide	14.50	9.85	26	68478	9542	90550401
Bone density decreased	14.50	9.85	37	68467	17308	90542635
Dilatation atrial	14.47	9.85	12	68492	1969	90557974
Cardiomegaly	14.43	9.85	39	68465	18886	90541057
Asphyxia	14.40	9.85	22	68482	7081	90552862
Septic shock	14.36	9.85	26	68478	84134	90475809
Sleep disorder due to a general medical condition	14.29	9.85	8	68496	44730	90515213
Vertigo	14.23	9.85	96	68408	69715	90490228
Flight of ideas	14.22	9.85	7	68497	463	90559480
Atrial fibrillation	14.18	9.85	159	68345	133452	90426491
Bruxism	14.18	9.85	17	68487	4346	90555597
Postmortem blood drug level increased	14.10	9.85	8	68496	707	90559236
Cardioactive drug level above therapeutic	14.05	9.85	5	68499	145	90559798
Depressed mood	14.04	9.85	75	68429	50147	90509796
Feeling abnormal	13.86	9.85	190	68314	167045	90392898
Mania	13.81	9.85	32	68472	14092	90545851
Liver function test increased	13.79	9.85	27	68477	84828	90475115
Transplant rejection	13.69	9.85	30	68474	12728	90547215
Pressure of speech	13.55	9.85	8	68496	762	90559181
Suspected counterfeit product	13.48	9.85	7	68497	519	90559424
Exposure via ingestion	13.25	9.85	13	68491	2654	90557289
Specific gravity urine decreased	13.22	9.85	8	68496	797	90559146
Blood albumin decreased	13.18	9.85	35	68469	16768	90543175
Hepatocellular injury	12.93	9.85	3	68501	28955	90530988
Akathisia	12.85	9.85	27	68477	11132	90548811
Atrioventricular block first degree	12.74	9.85	23	68481	8488	90551455
Depressed level of consciousness	12.47	9.85	96	68408	72688	90487255
Subendocardial ischaemia	12.41	9.85	4	68500	85	90559858
Eczema	12.37	9.85	13	68491	52857	90507086
Cholestasis	12.32	9.85	6	68498	36293	90523650
Jaundice	12.31	9.85	53	68451	32464	90527479
Bone disorder	12.31	9.85	42	68462	23078	90536865
Herpes zoster	12.26	9.85	34	68470	94610	90465333
Frequent bowel movements	12.23	9.85	15	68489	56920	90503023
Urinary tract infection	12.23	9.85	310	68194	305322	90254621
Blood glucose fluctuation	12.13	9.85	17	68487	5066	90554877
Suicide attempt	12.13	9.85	98	68406	75301	90484642
Retinitis	12.11	9.85	7	68497	38451	90521492
Dysstasia	12.04	9.85	44	68460	25008	90534935
Consciousness fluctuating	12.03	9.85	8	68496	938	90559005
Drug resistance	12.02	9.85	4	68500	30445	90529498
Snoring	12.02	9.85	17	68487	5109	90554834
Respiratory disorder	12.00	9.85	19	68485	64797	90495146
Malignant neoplasm progression	11.99	9.85	41	68463	106829	90453114
Microscopic polyangiitis	11.95	9.85	5	68499	226	90559717
Hepatitis	11.94	9.85	22	68482	70717	90489226
Photosensitivity reaction	11.91	9.85	35	68469	17772	90542171
Drug reaction with eosinophilia and systemic symptoms	11.82	9.85	9	68495	42749	90517194
Colitis ulcerative	11.80	9.85	17	68487	60249	90499694
Anti-cyclic citrullinated peptide antibody	11.80	9.85	3	68501	27218	90532725
Neonatal behavioural syndrome	11.76	9.85	4	68500	101	90559842
Limb injury	11.66	9.85	51	68453	31457	90528486
Insomnia	11.56	9.85	332	68172	333142	90226801
Limb discomfort	11.44	9.85	58	68446	38002	90521941
Acquired immunodeficiency syndrome	11.37	9.85	4	68500	112	90559831
Chronic obstructive pulmonary disease	11.36	9.85	95	68409	73734	90486209
Drug abuser	11.34	9.85	12	68492	2678	90557265
Stoma site discomfort	11.24	9.85	4	68500	116	90559827
Lethargy	11.23	9.85	84	68420	63055	90496888
Erosive oesophagitis	11.16	9.85	10	68494	1821	90558122
Psychotic disorder	11.14	9.85	50	68454	31180	90528763
Post-traumatic pain	11.10	9.85	6	68498	482	90559461
Anal hypoaesthesia	11.05	9.85	3	68501	34	90559909
Burning feet syndrome	11.05	9.85	4	68500	122	90559821
Pancytopenia	11.03	9.85	50	68454	120213	90439730
Needle issue	10.91	9.85	29	68475	13905	90546038
Oedema	10.79	9.85	98	68406	200197	90359746
Haematocrit decreased	10.71	9.85	61	68443	41771	90518172
Ear infection	10.66	9.85	23	68481	69752	90490191
Obsessive-compulsive disorder	10.65	9.85	15	68489	4489	90555454
Coronary artery disease	10.65	9.85	52	68452	33571	90526372
Poisoning deliberate	10.64	9.85	32	68472	16454	90543489
Febrile neutropenia	10.61	9.85	73	68431	158276	90401667
Clonus	10.53	9.85	17	68487	5733	90554210
Diarrhoea	10.49	9.85	592	67912	938598	89621345
Skin disorder	10.39	9.85	55	68449	36651	90523292
Posturing	10.27	9.85	6	68498	560	90559383
Neutrophil percentage increased	10.25	9.85	12	68492	2991	90556952
Angioedema	10.23	9.85	21	68483	64855	90495088
Renal infarct	10.20	9.85	9	68495	1606	90558337
Hyperlipidaemia	9.98	9.85	39	68465	22877	90537066
Food interaction	9.96	9.85	8	68496	1256	90558687
Injection site mass	9.95	9.85	38	68466	22052	90537891
Dysphagia	9.90	9.85	129	68375	112149	90447794
Lymphocyte percentage decreased	9.86	9.85	12	68492	3115	90556828

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	952.14	11.76	1036	33072	228100	42359127
Completed suicide	462.11	11.76	472	33636	95993	42491234
Drug abuse	397.04	11.76	453	33655	104318	42482909
Poisoning	223.72	11.76	142	33966	14557	42572670
Aggression	216.30	11.76	219	33889	43944	42543283
Substance abuse	184.74	11.76	105	34003	8800	42578427
Drug dependence	168.10	11.76	158	33950	28936	42558291
Overdose	159.62	11.76	295	33813	104969	42482258
Dysarthria	123.91	11.76	156	33952	39651	42547576
Logorrhoea	104.32	11.76	49	34059	2758	42584469
Off label use	96.87	11.76	232	33876	638103	41949124
Bradyphrenia	95.76	11.76	57	34051	5205	42582022
Dystonic tremor	95.67	11.76	27	34081	336	42586891
Intrusive thoughts	89.00	11.76	27	34081	439	42586788
Suicidal ideation	80.58	11.76	141	33967	48020	42539207
Restlessness	79.13	11.76	107	34001	29142	42558085
Bradykinesia	78.92	11.76	51	34057	5385	42581842
Depressed level of consciousness	78.39	11.76	139	33969	47831	42539396
Visceral congestion	77.64	11.76	29	34079	912	42586315
Abnormal behaviour	76.53	11.76	100	34008	26351	42560876
Cardio-respiratory arrest	72.57	11.76	151	33957	58485	42528742
Tachyphrenia	68.97	11.76	30	34078	1409	42585818
Homicidal ideation	66.29	11.76	36	34072	2758	42584469
Suicide attempt	64.55	11.76	125	33983	45975	42541252
Psychotic disorder	63.07	11.76	96	34012	29112	42558115
Drug ineffective	60.31	11.76	280	33828	629917	41957310
Arteriosclerosis coronary artery	57.77	11.76	73	34035	18604	42568623
Respiratory depression	55.61	11.76	72	34036	18796	42568431
Pulmonary congestion	54.34	11.76	65	34043	15665	42571562
Psychotic behaviour	52.71	11.76	22	34086	932	42586295
Insomnia	49.84	11.76	207	33901	118046	42469181
Anxiety	47.99	11.76	205	33903	118355	42468872
Injury	47.69	11.76	73	34035	22243	42564984
Coordination abnormal	47.00	11.76	44	34064	8006	42579221
Agitation	45.79	11.76	134	33974	64180	42523047
Accidental overdose	43.59	11.76	80	34028	28250	42558977
Accidental poisoning	43.21	11.76	21	34087	1275	42585952
Pulmonary oedema	42.83	11.76	116	33992	53156	42534071
Loss of libido	42.60	11.76	28	34080	3042	42584185
Drug interaction	41.27	11.76	359	33749	266640	42320587
Anger	40.45	11.76	51	34057	12967	42574260
Miosis	39.14	11.76	51	34057	13395	42573832
Irritability	37.82	11.76	75	34033	28053	42559174
Mental disorder	35.77	11.76	57	34051	17972	42569255
Drug level below therapeutic	34.85	11.76	34	34074	6511	42580716
Behaviour disorder	34.52	11.76	35	34073	7019	42580208
Fear	34.13	11.76	43	34065	10922	42576305
Hallucination, auditory	33.71	11.76	50	34058	14814	42572413
Sedation	33.68	11.76	75	34033	30400	42556827
Mood swings	33.02	11.76	38	34070	8788	42578439
Needle fatigue	32.64	11.76	17	34091	1196	42586031
Panic attack	32.31	11.76	42	34066	11003	42576224
Thinking abnormal	32.28	11.76	34	34074	7127	42580100
Emotional distress	32.09	11.76	51	34057	16042	42571185
Gait spastic	30.26	11.76	17	34091	1392	42585835
Relapsing-remitting multiple sclerosis	29.32	11.76	17	34091	1478	42585749
Restless legs syndrome	28.82	11.76	37	34071	9577	42577650
Febrile neutropenia	28.33	11.76	67	34041	185636	42401591
General physical health deterioration	27.80	11.76	49	34059	151197	42436030
Paranoia	27.35	11.76	44	34064	13982	42573245
Drug withdrawal syndrome	27.23	11.76	56	34052	21493	42565734
Depression	27.09	11.76	167	33941	111196	42476031
Feelings of worthlessness	26.79	11.76	10	34098	314	42586913
Emotional disorder	26.73	11.76	29	34079	6285	42580942
Hypertonic bladder	26.61	11.76	19	34089	2362	42584865
Condition aggravated	26.50	11.76	113	33995	260641	42326586
Asphyxia	26.47	11.76	33	34075	8293	42578934
Drug abuser	25.98	11.76	22	34086	3509	42583718
Dissociative disorder	25.80	11.76	12	34096	660	42586567
COVID-19	25.73	11.76	33	34075	115915	42471312
Drug screen positive	24.93	11.76	23	34085	4108	42583119
Memory impairment	24.42	11.76	92	34016	50130	42537097
Reduced facial expression	23.78	11.76	15	34093	1518	42585709
Brain oedema	23.73	11.76	45	34063	16282	42570945
Lethargy	23.72	11.76	87	34021	46803	42540424
Mesothelioma	23.71	11.76	10	34098	435	42586792
Interstitial lung disease	23.61	11.76	17	34091	78445	42508782
Gun shot wound	23.60	11.76	13	34095	1024	42586203
Gait disturbance	23.23	11.76	146	33962	97854	42489373
Withdrawal syndrome	23.08	11.76	42	34066	14733	42572494
Depressed mood	23.03	11.76	55	34053	23329	42563898
Patient uncooperative	22.76	11.76	11	34097	660	42586567
Dissociation	22.63	11.76	21	34087	3777	42583450
Homicide	22.29	11.76	12	34096	903	42586324
Vestibular disorder	22.07	11.76	13	34095	1164	42586063
Obsessive-compulsive disorder	21.88	11.76	27	34081	6716	42580511
Cardiac hypertrophy	21.82	11.76	13	34095	1188	42586039
Crystalluria	21.59	11.76	11	34097	739	42586488
Product use in unapproved indication	21.24	11.76	76	34032	184380	42402847
Amnesia	20.95	11.76	60	34048	28377	42558850
Monoparesis	20.88	11.76	18	34090	2942	42584285
Dystonia	20.79	11.76	37	34071	12753	42574474
Personality change	20.35	11.76	24	34084	5695	42581532
Congestive hepatopathy	19.95	11.76	16	34092	2366	42584861
Antasthmatic drug level	19.70	11.76	5	34103	40	42587187
Muscle contracture	19.70	11.76	13	34095	1422	42585805
Osmolar gap abnormal	19.59	11.76	5	34103	41	42587186
Analgesic drug level	19.38	11.76	5	34103	43	42587184
Confusional state	19.27	11.76	212	33896	167385	42419842
Cardiac asthma	18.71	11.76	7	34101	221	42587006
Somnambulism	18.67	11.76	18	34090	3397	42583830
Cognitive disorder	18.64	11.76	65	34043	34107	42553120
Intentional self-injury	18.61	11.76	39	34069	15163	42572064
Nervousness	18.09	11.76	36	34072	13496	42573731
Inappropriate schedule of product administration	17.68	11.76	31	34077	95871	42491356
Diarrhoea	17.39	11.76	262	33846	460587	42126640
Conduction disorder	17.13	11.76	15	34093	2503	42584724
Hepatic function abnormal	17.11	11.76	10	34098	51557	42535670
Muscle spasticity	17.00	11.76	24	34084	6798	42580429
Somnolence	16.92	11.76	180	33928	140925	42446302
Depersonalisation/derealisation disorder	16.90	11.76	9	34099	663	42586564
Injection site pain	16.77	11.76	13	34095	57785	42529442
Pruritus	16.68	11.76	86	34022	188685	42398542
Abulia	16.67	11.76	9	34099	681	42586546
Renal impairment	16.61	11.76	40	34068	110188	42477039
Joint swelling	16.54	11.76	18	34090	68004	42519223
Unresponsive to stimuli	16.50	11.76	59	34049	31344	42555883
Fall	16.34	11.76	271	33837	234249	42352978
Decreased interest	16.02	11.76	15	34093	2730	42584497
Sexually transmitted disease	15.99	11.76	4	34104	30	42587197
Gallbladder injury	15.91	11.76	6	34102	194	42587033
Starvation	15.84	11.76	8	34100	528	42586699
Pyrexia	15.55	11.76	222	33886	393820	42193407
Intentional product use issue	15.36	11.76	21	34087	71812	42515415
Exposure via ingestion	15.16	11.76	13	34095	2109	42585118
Thrombocytopenia	15.00	11.76	90	34018	190189	42397038
Cardiomegaly	14.99	11.76	38	34070	16728	42570499
Tumour flare	14.75	11.76	10	34098	1143	42586084
Cardiomyopathy	14.60	11.76	41	34067	19169	42568058
Blood disorder	14.53	11.76	17	34091	4000	42583227
Tangentiality	14.47	11.76	5	34103	125	42587102
Rash	14.36	11.76	147	33961	276807	42310420
Multiple organ dysfunction syndrome	14.00	11.76	36	34072	96999	42490228
Treatment failure	13.70	11.76	18	34090	62606	42524621
Cerebral arteriovenous malformation haemorrhagic	13.67	11.76	4	34104	57	42587170
Intentional overdose	13.67	11.76	79	34029	51377	42535850
Thalassaemia	13.61	11.76	4	34104	58	42587169
Nocturia	13.59	11.76	30	34078	12082	42575145
Daydreaming	13.59	11.76	8	34100	715	42586512
Anhedonia	13.59	11.76	23	34085	7617	42579610
Iron metabolism disorder	13.55	11.76	4	34104	59	42587168
Asthma	13.54	11.76	18	34090	62296	42524931
Conjunctival scar	13.44	11.76	6	34102	300	42586927
Aspiration	13.42	11.76	38	34070	17848	42569379
Adjustment disorder	13.39	11.76	10	34098	1332	42585895
Madarosis	13.36	11.76	7	34101	499	42586728
Gastrointestinal pain	13.24	11.76	17	34091	4398	42582829
Respiratory arrest	12.94	11.76	51	34057	28373	42558854
Victim of crime	12.87	11.76	7	34101	538	42586689
Movement disorder	12.81	11.76	33	34075	14665	42572562
Asteatosis	12.80	11.76	5	34103	178	42587049
Accidental death	12.77	11.76	14	34094	3069	42584158
Urticaria	12.69	11.76	25	34083	74011	42513216
Drug ineffective for unapproved indication	12.63	11.76	11	34097	46152	42541075
Cardiopulmonary failure	12.46	11.76	17	34091	4666	42582561
Physical disability	12.43	11.76	11	34097	1862	42585365
Hallucination, visual	12.36	11.76	41	34067	20979	42566248
Drug intolerance	12.26	11.76	29	34079	80395	42506832
Eczema	12.20	11.76	6	34102	34080	42553147
Contraindication to medical treatment	12.16	11.76	8	34100	870	42586357
Postmortem blood drug level abnormal	12.14	11.76	6	34102	378	42586849
Ventricular hypertrophy	12.09	11.76	17	34091	4799	42582428
Foetal exposure during pregnancy	12.08	11.76	12	34096	47299	42539928
Dysprosody	12.05	11.76	3	34105	22	42587205
Sexually inappropriate behaviour	11.99	11.76	7	34101	616	42586611
Peripheral swelling	11.90	11.76	35	34073	90235	42496992
Disease progression	11.82	11.76	67	34041	143589	42443638
Acute kidney injury	11.80	11.76	215	33893	367122	42220105
Tremor	11.77	11.76	124	33984	96805	42490422

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1303.18	10.11	1707	82219	478848	110026525
Completed suicide	1134.48	10.11	1143	82783	241238	110264135
Temperature regulation disorder	568.30	10.11	249	83677	12577	110492796
Overdose	487.53	10.11	734	83192	233060	110272313
Food allergy	463.72	10.11	249	83677	19699	110485674
Drug abuse	456.75	10.11	616	83310	176795	110328578
Immunodeficiency	342.41	10.11	263	83663	38575	110466798
Coeliac disease	301.23	10.11	255	83671	42932	110462441
Poisoning	287.49	10.11	211	83715	28894	110476479
Foetal death	259.27	10.11	158	83768	15887	110489486
Substance abuse	252.23	10.11	142	83784	12321	110493052
Fluid retention	229.69	10.11	319	83607	93988	110411385
Hyperhidrosis	220.62	10.11	458	83468	186840	110318533
Aggression	197.28	10.11	234	83692	58976	110446397
Rash erythematous	193.60	10.11	273	83653	81559	110423814
Drug dependence	158.95	10.11	193	83733	49827	110455546
Cardio-respiratory arrest	150.32	10.11	295	83631	115541	110389832
Back pain	147.73	10.11	615	83311	370381	110134992
Pemphigus	133.95	10.11	7	83919	214563	110290810
Respiratory arrest	126.91	10.11	187	83739	58112	110447261
Upper respiratory tract infection	125.02	10.11	295	83631	131033	110374340
Hand deformity	122.45	10.11	12	83914	218494	110286879
Intentional product misuse	118.42	10.11	291	83635	132613	110372760
Respiratory depression	117.52	10.11	133	83793	31868	110473505
Off label use	111.93	10.11	675	83251	1499510	109005863
Anti-cyclic citrullinated peptide antibody positive	110.34	10.11	7	83919	181977	110323396
Constipation	108.80	10.11	548	83378	357238	110148135
Accidental overdose	106.73	10.11	162	83764	51672	110453701
Pericarditis	104.05	10.11	20	83906	219094	110286279
Abnormal behaviour	104.02	10.11	138	83788	38901	110466472
Prescribed overdose	101.66	10.11	213	83713	87368	110418005
Dystonic tremor	100.63	10.11	28	83898	349	110505024
Bursitis	95.77	10.11	265	83661	129653	110375720
Arteriosclerosis coronary artery	94.98	10.11	106	83820	25012	110480361
Glossodynia	94.01	10.11	26	83900	221978	110283395
Suicidal ideation	93.75	10.11	215	83711	93722	110411651
Logorrhoea	93.64	10.11	54	83872	4903	110500470
Death	92.64	10.11	872	83054	697997	109807376
Restlessness	90.21	10.11	157	83769	56102	110449271
Folliculitis	89.38	10.11	11	83915	167642	110337731
Discomfort	89.34	10.11	26	83900	214681	110290692
Systemic lupus erythematosus	88.64	10.11	41	83885	254297	110251076
Duodenal ulcer perforation	87.00	10.11	15	83911	177685	110327688
Dysarthria	85.57	10.11	194	83732	83927	110421446
Synovitis	85.46	10.11	51	83875	274041	110231332
Myocardial depression	82.32	10.11	28	83898	704	110504669
Psoriasis	80.88	10.11	262	83664	139731	110365642
Maternal exposure during pregnancy	80.06	10.11	47	83879	254836	110250537
Irritability	80.04	10.11	136	83790	47673	110457700
Visceral congestion	79.27	10.11	32	83894	1313	110504060
Drug ineffective	78.76	10.11	757	83169	1519783	108985590
General physical health deterioration	77.53	10.11	127	83799	425168	110080205
Homicidal ideation	75.22	10.11	42	83884	3585	110501788
Asthma	73.67	10.11	380	83546	249911	110255462
Wound	72.55	10.11	44	83882	234393	110270980
Intrusive thoughts	71.10	10.11	25	83901	696	110504677
Decorticate posture	70.23	10.11	21	83905	343	110505030
Pulmonary congestion	69.81	10.11	101	83825	30865	110474508
Bradykinesia	69.71	10.11	61	83865	10727	110494646
Blister	68.53	10.11	44	83882	227332	110278041
Miosis	68.49	10.11	84	83842	21899	110483474
Libido increased	68.42	10.11	35	83891	2504	110502869
Depressed level of consciousness	68.38	10.11	214	83712	112064	110393309
Rheumatic fever	67.96	10.11	7	83919	122572	110382801
C-reactive protein abnormal	67.94	10.11	9	83917	129686	110375687
Bradyphrenia	67.26	10.11	62	83864	11666	110493707
Peripheral swelling	66.99	10.11	128	83798	403906	110101467
Rheumatoid factor positive	66.93	10.11	10	83916	131630	110373743
Intentional product use issue	66.84	10.11	54	83872	247852	110257521
Liver injury	66.77	10.11	16	83910	150397	110354976
Cardiac arrest	66.66	10.11	311	83615	196442	110308931
Carbuncle	66.66	10.11	29	83897	1438	110503935
Hostility	66.43	10.11	35	83891	2661	110502712
Swelling	65.68	10.11	103	83823	350938	110154435
Intentional overdose	65.15	10.11	235	83691	132266	110373107
Arthropathy	64.30	10.11	74	83852	287448	110217925
Soft tissue injury	63.15	10.11	32	83894	2244	110503129
Tachyphrenia	62.10	10.11	32	83894	2324	110503049
Post-traumatic neck syndrome	62.00	10.11	33	83893	2562	110502811
Sternal fracture	59.66	10.11	35	83891	3281	110502092
Mental disorder	59.27	10.11	106	83820	38685	110466688
Myelosuppression	59.11	10.11	3	83923	94337	110411036
Victim of sexual abuse	58.21	10.11	20	83906	519	110504854
Irritable bowel syndrome	57.93	10.11	26	83900	164189	110341184
Accidental poisoning	57.66	10.11	31	83895	2456	110502917
Decreased immune responsiveness	57.47	10.11	52	83874	9554	110495819
Polyp	55.77	10.11	52	83874	9928	110495445
Ill-defined disorder	55.08	10.11	25	83901	156828	110348545
Somnolence	54.76	10.11	400	83526	297049	110208324
Judgement impaired	53.06	10.11	24	83902	1306	110504067
Suicide attempt	52.21	10.11	185	83741	103209	110402164
Psychotic disorder	51.27	10.11	117	83809	50820	110454553
Gastrointestinal disorder	51.20	10.11	65	83861	241887	110263486
Condition aggravated	50.71	10.11	338	83588	734498	109770875
Impaired healing	50.39	10.11	45	83881	196672	110308701
Therapeutic product effect decreased	49.29	10.11	68	83858	244248	110261125
Psychotic behaviour	48.40	10.11	23	83903	1402	110503971
Pulmonary oedema	48.18	10.11	177	83749	100482	110404891
Lung disorder	47.56	10.11	40	83886	180007	110325366
Homicide	47.46	10.11	21	83905	1085	110504288
Muscle injury	47.06	10.11	24	83902	140783	110364590
Wheezing	46.68	10.11	76	83850	255154	110250219
Mood swings	46.53	10.11	71	83855	22741	110482632
Monoclonal immunoglobulin present	46.20	10.11	27	83899	2513	110502860
Nasopharyngitis	45.80	10.11	150	83776	394211	110111162
Interstitial lung disease	44.73	10.11	25	83901	139309	110366064
Urticaria	44.58	10.11	111	83815	318746	110186627
Rectal polyp	43.75	10.11	22	83904	1518	110503855
Coma scale abnormal	43.74	10.11	45	83881	9681	110495692
Lip dry	43.72	10.11	11	83915	100072	110405301
Facet joint syndrome	43.56	10.11	10	83916	96818	110408555
Loss of libido	43.43	10.11	28	83898	3105	110502268
Swollen joint count increased	43.36	10.11	6	83920	83655	110421718
Change of bowel habit	43.16	10.11	27	83899	2842	110502531
Abdominal discomfort	42.90	10.11	154	83772	393704	110111669
Movement disorder	42.77	10.11	89	83837	36315	110469058
Overweight	42.67	10.11	37	83889	6427	110498946
Breast cancer stage III	42.63	10.11	5	83921	79112	110426261
Agitation	42.24	10.11	184	83742	112867	110392506
Drug abuser	41.99	10.11	34	83892	5375	110499998
Product use in unapproved indication	41.73	10.11	186	83740	447191	110058182
Night sweats	41.64	10.11	25	83901	133958	110371415
Drug withdrawal syndrome	41.20	10.11	90	83836	37964	110467409
Neutropenia	41.12	10.11	146	83780	374474	110130899
Hypothalamo-pituitary disorder	40.85	10.11	26	83900	2820	110502553
Asphyxia	40.59	10.11	52	83874	14163	110491210
Behaviour disorder	40.46	10.11	43	83883	9604	110495769
Anxiety	40.43	10.11	420	83506	344658	110160715
Stomatitis	40.22	10.11	91	83835	270151	110235222
Unresponsive to stimuli	40.14	10.11	123	83803	63667	110441706
Arthralgia	39.78	10.11	389	83537	779243	109726130
Inflammation	39.76	10.11	53	83873	193185	110312188
Psoriatic arthropathy	39.44	10.11	55	83871	196706	110308667
Withdrawal syndrome	38.37	10.11	78	83848	31302	110474071
Gait spastic	37.86	10.11	20	83906	1529	110503844
Sedation	37.18	10.11	127	83799	69556	110435817
Amblyopia	35.92	10.11	12	83914	285	110505088
Kyphosis	35.81	10.11	25	83901	3162	110502211
Accidental death	35.78	10.11	30	83896	4979	110500394
Poor quality sleep	35.78	10.11	71	83855	28006	110477367
Body height decreased	35.58	10.11	42	83884	10521	110494852
Fibrosis	35.53	10.11	36	83890	7606	110497767
Peripheral venous disease	35.32	10.11	10	83916	84107	110421266
Drug screen positive	35.05	10.11	33	83893	6377	110498996
Pruritus	35.01	10.11	278	83648	581282	109924091
Alopecia	35.00	10.11	150	83776	364603	110140770
Mental impairment	34.76	10.11	62	83864	22577	110482796
Urine odour abnormal	34.60	10.11	35	83891	7380	110497993
Hepatic steatosis	34.38	10.11	98	83828	48733	110456640
Panic attack	34.28	10.11	71	83855	28869	110476504
Hepatic enzyme increased	34.07	10.11	383	83543	320509	110184864
Live birth	33.70	10.11	6	83920	69478	110435895
Therapeutic product effect incomplete	33.59	10.11	75	83851	223730	110281643
Wrist deformity	33.49	10.11	24	83902	3165	110502208
Rectal prolapse	33.31	10.11	22	83904	2541	110502832
Needle fatigue	32.83	10.11	17	83909	1247	110504126
Paranoia	32.73	10.11	60	83866	22314	110483059
Impaired reasoning	32.66	10.11	9	83917	108	110505265
Toxicologic test abnormal	32.30	10.11	17	83909	1290	110504083
Rib fracture	32.26	10.11	76	83850	33694	110471679
Sensitisation	32.03	10.11	26	83900	4125	110501248
Pulmonary fibrosis	31.76	10.11	19	83907	102023	110403350
Venous pressure jugular increased	31.76	10.11	17	83909	1335	110504038
COVID-19	31.44	10.11	89	83837	244971	110260402
Grip strength decreased	31.04	10.11	11	83915	80163	110425210
Diarrhoea	30.94	10.11	645	83281	1138860	109366513
Duodenal ulcer	30.68	10.11	54	83872	19460	110485913
Mobility decreased	29.89	10.11	87	83839	237335	110268038
C-reactive protein increased	29.56	10.11	77	83849	217842	110287531
Lethargy	28.84	10.11	144	83782	93432	110411941
Insomnia	28.72	10.11	408	83518	360182	110145191
Wound infection	28.60	10.11	19	83907	96446	110408927
Exposure via ingestion	28.29	10.11	26	83900	4874	110500499
Frustration tolerance decreased	28.23	10.11	34	83892	8697	110496676
Helicobacter infection	28.08	10.11	60	83866	181817	110323556
Thinking abnormal	27.93	10.11	45	83881	15095	110490278
Mass	27.91	10.11	52	83874	19578	110485795
Febrile neutropenia	27.57	10.11	135	83791	316632	110188741
Relapsing-remitting multiple sclerosis	27.37	10.11	18	83908	2064	110503309
Cardiomegaly	27.22	10.11	65	83861	29065	110476308
Thiopurine methyltransferase decreased	26.86	10.11	10	83916	329	110505044
Depressed mood	26.67	10.11	104	83822	60705	110444668
Coordination abnormal	26.56	10.11	59	83867	25169	110480204
Musculoskeletal stiffness	26.27	10.11	116	83810	279706	110225667
Transplant dysfunction	26.23	10.11	32	83894	8296	110497077
Apnoea	25.79	10.11	41	83885	13598	110491775
Tremor	25.51	10.11	250	83676	201982	110303391
Brain oedema	25.49	10.11	66	83860	31032	110474341
Dry mouth	25.36	10.11	73	83853	199875	110305498
Anger	25.35	10.11	49	83877	18958	110486415
Restless legs syndrome	25.26	10.11	57	83869	24569	110480804
Deep vein thrombosis postoperative	24.98	10.11	7	83919	59284	110446089
Dyslipidaemia	24.87	10.11	44	83882	15921	110489452
Personality disorder	24.85	10.11	39	83887	12798	110492575
Obsessive-compulsive disorder	24.74	10.11	29	83897	7212	110498161
Obesity	24.44	10.11	30	83896	113321	110392052
Epilepsy	24.39	10.11	24	83902	100185	110405188
Septic shock	24.29	10.11	52	83874	157476	110347897
Dehydration	24.18	10.11	321	83605	279190	110226183
Type 2 diabetes mellitus	23.75	10.11	63	83863	177169	110328204
Cytomegalovirus infection	23.75	10.11	6	83920	54438	110450935
Erythema	23.69	10.11	331	83595	291116	110214257
Concussion	23.66	10.11	36	83890	11502	110493871
Cardiac hypertrophy	23.59	10.11	16	83910	1931	110503442
Blood glucose decreased	23.57	10.11	62	83864	29426	110475947
Rheumatoid arthritis	23.45	10.11	338	83588	299275	110206098
Potentiating drug interaction	23.41	10.11	36	83890	11607	110493766
Sinusitis	23.26	10.11	131	83795	296557	110208816
Hepatocellular injury	23.24	10.11	5	83921	50637	110454736
Urine oxalate increased	22.84	10.11	8	83918	220	110505153
Intestinal haemorrhage	22.78	10.11	28	83898	7313	110498060
Drug interaction	22.74	10.11	518	83408	499665	110005708
Retching	22.71	10.11	52	83874	22630	110482743
Therapy non-responder	22.57	10.11	54	83872	157253	110348120
Myelocyte percentage increased	22.54	10.11	8	83918	229	110505144
Injection site discomfort	22.50	10.11	27	83899	6880	110498493
Urine abnormality	22.47	10.11	31	83895	9065	110496308
Somnambulism	22.46	10.11	26	83900	6379	110498994
Emotional distress	22.42	10.11	80	83846	44767	110460606
Hepatic cytolysis	22.28	10.11	7	83919	55046	110450327
Bruxism	22.26	10.11	23	83903	4971	110500402
Delusion	22.19	10.11	53	83873	23702	110481671
Blepharospasm	22.15	10.11	7	83919	54844	110450529
Autoimmune disorder	22.12	10.11	11	83915	65472	110439901
Furuncle	22.11	10.11	30	83896	8638	110496735
Loss of consciousness	22.06	10.11	237	83689	196069	110309304
Fibromyalgia	21.97	10.11	62	83864	170847	110334526
Fear	21.94	10.11	52	83874	23141	110482232
Eczema	21.75	10.11	14	83912	72279	110433094
Depression	21.75	10.11	350	83576	316985	110188388
Hypothermia	21.74	10.11	56	83870	26246	110479127
Band neutrophil percentage increased	21.72	10.11	9	83917	395	110504978
Proctalgia	21.32	10.11	37	83889	13185	110492188
Frequent bowel movements	21.24	10.11	14	83912	71376	110433997
Ovarian cyst	21.19	10.11	38	83888	13892	110491481
Feeling abnormal	21.16	10.11	220	83706	180491	110324882
Acute kidney injury	21.14	10.11	347	83579	635083	109870290
Gait inability	21.04	10.11	45	83881	136331	110369042
Hip arthroplasty	21.03	10.11	8	83918	55805	110449568
Hepatic function abnormal	21.03	10.11	22	83904	89273	110416100
Hypercholesterolaemia	20.70	10.11	23	83903	90814	110414559
Gun shot wound	20.70	10.11	12	83914	1100	110504273
Cardiomyopathy	20.49	10.11	64	83862	33461	110471912
Bone erosion	20.44	10.11	5	83921	46366	110459007
Lower respiratory tract infection	20.35	10.11	105	83821	243001	110262372
Knee arthroplasty	20.34	10.11	12	83914	64936	110440437
Pancytopenia	20.21	10.11	86	83840	209527	110295846
Postmortem blood drug level	20.20	10.11	8	83918	312	110505061
Anaemia	20.15	10.11	293	83633	546793	109958580
Cholestasis	20.10	10.11	12	83914	64506	110440867
Pneumocystis jirovecii pneumonia	20.07	10.11	4	83922	42731	110462642
Antasthmatic drug level	19.97	10.11	5	83921	40	110505333
Fall	19.62	10.11	598	83328	602884	109902489
Blood cholesterol increased	19.60	10.11	73	83853	184712	110320661
Patient uncooperative	19.59	10.11	11	83915	949	110504424
Abdominal pain upper	19.56	10.11	170	83756	348941	110156432
Emotional disorder	19.56	10.11	40	83886	16120	110489253
Dilatation atrial	19.49	10.11	19	83907	3833	110501540
Analgesic drug level	19.44	10.11	5	83921	45	110505328
Colitis ulcerative	19.44	10.11	18	83908	77345	110428028
Hypertonic bladder	19.40	10.11	22	83904	5280	110500093
Dissociative disorder	19.39	10.11	12	83914	1239	110504134
Inappropriate schedule of product administration	19.36	10.11	84	83842	203553	110301820
Retinal depigmentation	19.16	10.11	8	83918	358	110505015
Antidepressant drug level above therapeutic	19.14	10.11	10	83916	747	110504626
Mucosal inflammation	19.13	10.11	27	83899	96114	110409259
Drug-induced liver injury	19.04	10.11	39	83887	120028	110385345
Sleep disorder due to a general medical condition	18.77	10.11	8	83918	52104	110453269
Red blood cell sedimentation rate increased	18.77	10.11	19	83907	78283	110427090
Rash	18.76	10.11	477	83449	820487	109684886
Paraesthesia	18.61	10.11	128	83798	276393	110228980
Infected dermal cyst	18.57	10.11	12	83914	1336	110504037
Feelings of worthlessness	18.46	10.11	9	83917	581	110504792
Headache	18.42	10.11	832	83094	881545	109623828
Aspiration	18.40	10.11	58	83868	30475	110474898
Nephropathy	18.31	10.11	35	83891	13432	110491941
Victim of crime	18.29	10.11	12	83914	1371	110504002
Rebound psychosis	18.14	10.11	8	83918	410	110504963
Onychomadesis	18.14	10.11	6	83920	45657	110459716
Diabetes mellitus	17.89	10.11	133	83793	99248	110406125
Piloerection	17.85	10.11	10	83916	859	110504514
Bladder disorder	17.74	10.11	31	83895	11106	110494267
Injection site reaction	17.74	10.11	25	83901	89045	110416328
Nail disorder	17.73	10.11	11	83915	57924	110447449
Gait disturbance	17.64	10.11	303	83623	277905	110227468
Renal cyst	17.47	10.11	41	83885	18131	110487242
Upper respiratory tract congestion	17.40	10.11	16	83910	3001	110502372
Bipolar I disorder	16.99	10.11	14	83912	2269	110503104
Dislocation of vertebra	16.92	10.11	6	83920	43715	110461658
Bundle branch block left	16.92	10.11	33	83893	12855	110492518
Mania	16.90	10.11	44	83882	20752	110484621
Monoparesis	16.84	10.11	19	83907	4534	110500839
Band neutrophil count increased	16.82	10.11	9	83917	706	110504667
Dystrophic calcification	16.74	10.11	6	83920	177	110505196
Hallucination, auditory	16.70	10.11	51	83875	26346	110479027
Multiple sclerosis relapse	16.69	10.11	79	83847	50161	110455212
Taste disorder	16.68	10.11	15	83911	65372	110440001
Drug ineffective for unapproved indication	16.65	10.11	33	83893	102805	110402568
Snoring	16.58	10.11	23	83903	6761	110498612
Vomiting	16.56	10.11	546	83380	910129	109595244
Congestive hepatopathy	16.35	10.11	20	83906	5200	110500173
Therapy partial responder	16.33	10.11	4	83922	37057	110468316
Middle insomnia	16.28	10.11	43	83883	20459	110484914
Pressure of speech	16.27	10.11	11	83915	1321	110504052
Lower limb fracture	16.18	10.11	20	83906	75328	110430045
Crystalluria	16.10	10.11	11	83915	1344	110504029
Arrhythmia	16.05	10.11	99	83827	69476	110435897
Hospitalisation	15.97	10.11	55	83871	142438	110362935
Osmolar gap abnormal	15.97	10.11	5	83921	96	110505277
Hypertension	15.92	10.11	503	83423	509581	109995792
Poisoning deliberate	15.85	10.11	50	83876	26281	110479092
Akathisia	15.79	10.11	38	83888	17075	110488298
Flight of ideas	15.71	10.11	9	83917	807	110504566
Gallbladder disorder	15.58	10.11	43	83883	20986	110484387
Bone density decreased	15.21	10.11	36	83890	16006	110489367
Skin exfoliation	15.18	10.11	27	83899	87624	110417749
Nightmare	15.08	10.11	64	83862	38799	110466574
Cardiac failure congestive	15.01	10.11	178	83748	150822	110354551
Lip swelling	14.99	10.11	10	83916	50657	110454716
Bacterial test	14.96	10.11	10	83916	1179	110504194
Memory impairment	14.93	10.11	221	83705	196723	110308650
Herpes zoster	14.92	10.11	38	83888	108341	110397032
Haemorrhoids	14.83	10.11	60	83866	35612	110469761
Iron metabolism disorder	14.80	10.11	5	83921	123	110505250
Myelocyte count increased	14.76	10.11	9	83917	905	110504468
Liver function test increased	14.70	10.11	28	83898	88520	110416853
Tumour flare	14.66	10.11	11	83915	1556	110503817
Abdominal pain	14.56	10.11	288	83638	512701	109992672
Opiates positive	14.54	10.11	9	83917	930	110504443
Neurotoxicity	14.39	10.11	7	83919	42200	110463173
Drug resistance	14.30	10.11	13	83913	56361	110449012
Suspected suicide	14.29	10.11	34	83892	15165	110490208
Device expulsion	14.28	10.11	3	83923	30888	110474485
Cardiac asthma	14.24	10.11	6	83920	275	110505098
Coronary artery disease	14.09	10.11	98	83828	71592	110433781
Drug eruption	14.06	10.11	12	83914	53647	110451726
Adjustment disorder with depressed mood	13.90	10.11	8	83918	43875	110461498
Substance use	13.89	10.11	13	83913	2493	110502880
Starvation	13.83	10.11	9	83917	1014	110504359
Analgesic drug level above therapeutic	13.67	10.11	7	83919	502	110504871
Brain injury	13.61	10.11	31	83895	13445	110491928
Hypokalaemia	13.52	10.11	82	83844	182366	110323007
Vestibular disorder	13.35	10.11	13	83913	2619	110502754
Fibrinolysis	13.23	10.11	4	83922	68	110505305
Angioedema	13.20	10.11	35	83891	98465	110406908
Malignant neoplasm progression	13.18	10.11	78	83848	174489	110330884
Thrombotic microangiopathy	13.13	10.11	3	83923	29146	110476227
Accident	13.13	10.11	27	83899	10925	110494448
Ventricular hypertrophy	13.08	10.11	21	83905	7024	110498349
Urinary incontinence	13.06	10.11	72	83854	48515	110456858
Forced vital capacity abnormal	13.02	10.11	4	83922	72	110505301
Breast cancer male	12.95	10.11	6	83920	345	110505028
Thyroid disorder	12.88	10.11	35	83891	16934	110488439
Dystonia	12.87	10.11	46	83880	25759	110479614
Seasonal affective disorder	12.86	10.11	6	83920	351	110505022
Nocturia	12.85	10.11	35	83891	16955	110488418
Rash maculo-papular	12.73	10.11	23	83903	74199	110431174
Product use issue	12.69	10.11	318	83608	311377	110193996
Ventricular hypokinesia	12.69	10.11	27	83899	11187	110494186
Haematochezia	12.67	10.11	45	83881	115479	110389894
Product dose omission issue	12.66	10.11	170	83756	321612	110183761
Screaming	12.61	10.11	17	83909	4864	110500509
Hallucination	12.59	10.11	125	83801	101307	110404066
Mesothelioma	12.59	10.11	6	83920	368	110505005
Decreased interest	12.54	10.11	17	83909	4891	110500482
Bone disorder	12.53	10.11	40	83886	21152	110484221
Bronchiectasis	12.52	10.11	6	83920	36487	110468886
Specific gravity urine decreased	12.48	10.11	8	83918	878	110504495
Transaminases increased	12.42	10.11	18	83908	63372	110442001
Postmortem blood drug level increased	12.41	10.11	9	83917	1208	110504165
Oesophagitis ulcerative	12.27	10.11	10	83916	1595	110503778
Dysprosody	12.21	10.11	3	83923	22	110505351
Premature delivery	12.21	10.11	4	83922	30628	110474745
Muscle twitching	12.17	10.11	50	83876	29885	110475488
Tangentiality	12.14	10.11	5	83921	216	110505157
X-ray abnormal	12.00	10.11	7	83919	38110	110467263
Gallbladder injury	11.96	10.11	9	83917	1279	110504094
Personality change	11.89	10.11	26	83900	10976	110494397
Sexually inappropriate behaviour	11.86	10.11	7	83919	664	110504709
Conduction disorder	11.84	10.11	15	83911	4040	110501333
Abulia	11.80	10.11	9	83917	1304	110504069
Musculoskeletal discomfort	11.77	10.11	42	83884	23496	110481877
Bronchopulmonary aspergillosis	11.73	10.11	4	83922	29859	110475514
No adverse event	11.69	10.11	24	83902	73815	110431558
Cardioactive drug level above therapeutic	11.57	10.11	5	83921	244	110505129
Pregnancy	11.56	10.11	13	83913	51054	110454319
Dissociation	11.49	10.11	24	83902	9818	110495555
Postural reflex impairment	11.47	10.11	3	83923	29	110505344
Reduced facial expression	11.45	10.11	14	83912	3637	110501736
Prescribed underdose	11.36	10.11	20	83906	65154	110440219
Multiple sclerosis	11.31	10.11	44	83882	25654	110479719
Subendocardial ischaemia	11.25	10.11	4	83922	115	110505258
Abortion spontaneous	11.22	10.11	6	83920	34276	110471097
Cyclothymic disorder	11.20	10.11	5	83921	264	110505109
Joint range of motion decreased	11.13	10.11	51	83875	121781	110383592
Dysgeusia	11.12	10.11	91	83835	69894	110435479
Mental status changes	11.05	10.11	97	83829	76025	110429348
Neutrophil percentage increased	11.04	10.11	16	83910	4897	110500476
Asteatosis	11.02	10.11	5	83921	274	110505099
Transient global amnesia	11.01	10.11	8	83918	1077	110504296
Micturition urgency	11.00	10.11	36	83890	19284	110486089
Lupus vulgaris	10.98	10.11	6	83920	33877	110471496
Peripheral coldness	10.97	10.11	35	83891	18505	110486868
Anaphylactic reaction	10.95	10.11	47	83879	114253	110391120
Muscle contracture	10.87	10.11	12	83914	2796	110502577
Paraesthesia oral	10.86	10.11	6	83920	33665	110471708
Appendicitis	10.86	10.11	4	83922	28460	110476913
Nervousness	10.86	10.11	56	83870	36795	110468578
Eosinophilia	10.82	10.11	17	83909	57919	110447454
Hypersomnia	10.73	10.11	46	83880	28015	110477358
Agranulocytosis	10.72	10.11	19	83907	61741	110443632
Blood creatinine increased	10.71	10.11	88	83838	182801	110322572
Suspected counterfeit product	10.67	10.11	7	83919	799	110504574
Alcohol poisoning	10.53	10.11	22	83904	8998	110496375
Gamma-glutamyltransferase increased	10.52	10.11	19	83907	61290	110444083
Impaired driving ability	10.50	10.11	18	83908	6352	110499021
Postoperative wound infection	10.50	10.11	31	83895	15722	110489651
Crystal urine present	10.48	10.11	10	83916	1964	110503409
Blood pressure fluctuation	10.48	10.11	26	83900	74798	110430575
Dihydrotestosterone increased	10.46	10.11	3	83923	42	110505331
Proteinuria	10.43	10.11	9	83917	40009	110465364
Thalassaemia	10.35	10.11	4	83922	146	110505227
Toxic skin eruption	10.27	10.11	4	83922	27511	110477862
Pollakiuria	10.26	10.11	63	83863	44132	110461241
Major depression	10.25	10.11	24	83902	10597	110494776
Breast cancer stage II	10.19	10.11	4	83922	27371	110478002
Purpura	10.12	10.11	41	83885	24347	110481026

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CD07	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
FDA EPC	N0000175694	Benzodiazepine
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35476	antipsychotic agent

Related Drugs by ATC class:

N05CD Benzodiazepine derivatives 14 drugs

brotizolam cinolazepam doxefazepam estazolam flunitrazepam flurazepam loprazolam lormetazepam midazolam nimetazepam nitrazepam quazepam show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Insomnia	indication	193462001
Suicidal thoughts	contraindication	6471006
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Disease of liver	contraindication	235856003	DOID:409
Sleep automatism	contraindication	247962006
Pregnancy, function	contraindication	289908002
Severe chronic obstructive pulmonary disease	contraindication	313299006
Memory impairment	contraindication	386807006
Chronic lung disease	contraindication	413839001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.07	acidic
pKa2	1.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR				WOMBAT-PK	CHEMBL
Nuclear receptor subfamily 1 group I member 3	Nuclear hormone receptor	Q14994	NR1I3_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017894	VUID
N0000146246	NUI
D00370	KEGG_DRUG
4017894	VANDF
C0039468	UMLSCUI
CHEBI:9435	CHEBI
CHEMBL967	ChEMBL_ID
DB00231	DRUGBANK_ID
D013693	MESH_DESCRIPTOR_UI
5391	PUBCHEM_CID
7300	IUPHAR_LIGAND_ID
2753	INN_ID
CHB1QD2QSS	UNII
10355	RXNORM
2322	MMSL
5544	MMSL
d00384	MMSL
001450	NDDF
387300007	SNOMEDCT_US
54705000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2076	CAPSULE	15 mg	ORAL	ANDA	18 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2077	CAPSULE	30 mg	ORAL	ANDA	18 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9914	CAPSULE	22.50 mg	ORAL	NDA	23 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9915	CAPSULE	7.50 mg	ORAL	NDA	23 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9916	CAPSULE	15 mg	ORAL	NDA	23 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9917	CAPSULE	30 mg	ORAL	NDA	23 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9959	CAPSULE	22.50 mg	ORAL	NDA	23 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9960	CAPSULE	7.50 mg	ORAL	NDA	23 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9961	CAPSULE	15 mg	ORAL	NDA	23 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9962	CAPSULE	30 mg	ORAL	NDA	23 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6436	CAPSULE	7.50 mg	ORAL	ANDA	23 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-214	CAPSULE	15 mg	ORAL	ANDA	14 sections
temazepam	Human Prescription Drug Label	1	17856-0148	CAPSULE	15 mg	ORAL	ANDA	23 sections
temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	21695-282	CAPSULE	15 mg	ORAL	ANDA	24 sections
temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	21695-283	CAPSULE	30 mg	ORAL	ANDA	24 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	33261-101	CAPSULE	15 mg	ORAL	ANDA	23 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	33261-102	CAPSULE	30 mg	ORAL	ANDA	23 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	33358-332	CAPSULE	15 mg	ORAL	ANDA	18 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	40032-120	CAPSULE	7.50 mg	ORAL	ANDA	17 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	40032-121	CAPSULE	15 mg	ORAL	ANDA	17 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	40032-122	CAPSULE	22.50 mg	ORAL	ANDA	17 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	40032-123	CAPSULE	30 mg	ORAL	ANDA	17 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	42549-561	CAPSULE	30 mg	ORAL	ANDA	21 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	42549-651	CAPSULE	15 mg	ORAL	ANDA	21 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-152	CAPSULE	7.50 mg	ORAL	ANDA	17 sections
temazepam	Human Prescription Drug Label	1	43353-260	CAPSULE	30 mg	ORAL	ANDA	24 sections
temazepam	Human Prescription Drug Label	1	43353-312	CAPSULE	15 mg	ORAL	ANDA	24 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-711	CAPSULE	7.50 mg	ORAL	ANDA	21 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43547-611	CAPSULE	7.50 mg	ORAL	ANDA	26 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43547-612	CAPSULE	15 mg	ORAL	ANDA	26 sections

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temazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: