DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
loprazolam 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diazepam derivatives
1602
61197-73-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
loprazolam mesylate
loprazolam
loprazolam mesilate
Molecular weight: 464.91
Formula: C23H21ClN6O3
CLOGP: 0.43
LIPINSKI: 0
HAC: 9
HDO: 0
TPSA: 97.33
ALOGS: -3.71
ROTB: 3
Drug dosage:
Dose
Unit
Route
1
mg
O
ADMET properties:
None
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 1, 1983
YEAR INTRODUCED
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Coma
167.10
48.62
48
518
64316
63424140
Pyramidal tract syndrome
78.56
48.62
11
555
352
63488104
Hepatocellular injury
68.71
48.62
20
546
27361
63461095
Bundle branch block right
55.32
48.62
12
554
4986
63483470
Bradypnoea
53.50
48.62
11
555
3539
63484917
Somnolence
51.59
48.62
27
539
178658
63309798
Miosis
50.71
48.62
12
554
7341
63481115
Showing 1 to 7 of 7 entries
Previous
1
Next
FDA Adverse Event Reporting System (Male)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Rhabdomyolysis
58.54
50.76
24
396
68139
34888372
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Geriatric)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Coma
191.33
37.21
65
985
100584
79642754
Miosis
90.45
37.21
24
1026
15765
79727573
Somnolence
78.71
37.21
45
1005
238936
79504402
Pyramidal tract syndrome
61.54
37.21
10
1040
587
79742751
Bradypnoea
58.53
37.21
14
1036
6038
79737300
Hepatocellular injury
53.58
37.21
21
1029
47572
79695766
Toxicity to various agents
53.36
37.21
44
1006
421496
79321842
Rhabdomyolysis
49.45
37.21
25
1025
103106
79640232
Showing 1 to 8 of 8 entries
Previous
1
Next
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
N05CD11
NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine derivatives
Showing 1 to 1 of 1 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Insomnia
indication
193462001
Showing 1 to 1 of 1 entries
Previous
1
Next
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.28
Basic
pKa2
4.28
Basic
pKa3
2.6
Basic
pKa4
1.98
Basic
Showing 1 to 4 of 4 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
GABA-A receptor alpha-2/beta-3/gamma-2
Ion channel
P18507
P28472
P47869
GBRG2_HUMAN
GBRB3_HUMAN
GBRA2_HUMAN
WOMBAT-PK
GABA-A receptor alpha-3/beta-3/gamma-2
Ion channel
P18507
P28472
P34903
GBRG2_HUMAN
GBRB3_HUMAN
GBRA3_HUMAN
WOMBAT-PK
GABA-A receptor alpha-5/beta-3/gamma-2
Ion channel
P18507
P28472
P31644
GBRG2_HUMAN
GBRB3_HUMAN
GBRA5_HUMAN
WOMBAT-PK
GABA-A receptor alpha-1/beta-3/gamma-2
Ion channel
P14867
P18507
P28472
GBRA1_HUMAN
GBRG2_HUMAN
GBRB3_HUMAN
WOMBAT-PK
Showing 1 to 4 of 4 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
004097
NDDF
004098
NDDF
235846
RXNORM
3033860
PUBCHEM_CID
321119005
SNOMEDCT_US
395774003
SNOMEDCT_US
442011001
SNOMEDCT_US
4884
INN_ID
70111-54-5
SECONDARY_CAS_RN
759N8462G8
UNII
Showing 1 to 10 of 15 entries
Previous
1
2
Next
Pharmaceutical products:
None
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
loprazolam