All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

lormetazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	1608	848-75-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lormetazepam methyllorazepam N-Methyllorazepam	Molecular weight: 335.18 Formula: C16H12Cl2N2O2 CLOGP: 2.40 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 52.90 ALOGS: -4.31 ROTB: 1

Drug dosage:

Dose	Unit	Route
1	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	75 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.60 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.12 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	4.90 hours	Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,PDK1,PDK2,PDK4	7
kinase-selectivity-class	AXL,EIF2AK3,GRK2,PDK4	4
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	677.78	27.57	281	11818	72351	90543997
Drug abuse	640.51	27.57	280	11819	82067	90534281
Poisoning deliberate	499.11	27.57	153	11946	16333	90600015
Somnolence	336.94	27.57	254	11845	208830	90407518
Intentional overdose	276.47	27.57	166	11933	93668	90522680
Drug dependence	268.01	27.57	112	11987	29215	90587133
Sopor	248.53	27.57	101	11998	24543	90591805
Toxicity to various agents	245.33	27.57	243	11856	287603	90328745
Drug interaction	211.06	27.57	220	11879	276233	90340115
Drug use disorder	208.79	27.57	67	12032	8276	90608072
Prescription form tampering	201.02	27.57	40	12059	687	90615661
Miosis	192.43	27.57	65	12034	9419	90606929
Suicide attempt	190.46	27.57	121	11978	75278	90541070
Depressed level of consciousness	171.95	27.57	112	11987	72672	90543676
Poisoning	155.55	27.57	63	12036	15154	90601194
Hypotension	151.39	27.57	201	11898	325196	90291152
Overdose	122.75	27.57	127	11972	157582	90458766
Serotonin syndrome	113.92	27.57	68	12031	37819	90578529
Altered state of consciousness	111.82	27.57	63	12036	31469	90584879
Intentional product misuse	109.96	27.57	93	12006	89511	90526837
Bradyphrenia	107.99	27.57	40	12059	7572	90608776
Electrocardiogram QT prolonged	105.31	27.57	83	12016	72373	90543975
Rhabdomyolysis	97.46	27.57	69	12030	51187	90565161
Vasoplegia syndrome	93.12	27.57	28	12071	2786	90613562
Fall	93.12	27.57	201	11898	481609	90134739
Hypothermia	92.45	27.57	44	12055	15531	90600817
Asphyxia	88.70	27.57	34	12065	7069	90609279
Substance use disorder	88.53	27.57	25	12074	1995	90614353
Pneumonia aspiration	79.88	27.57	56	12043	40884	90575464
Bradypnoea	79.26	27.57	28	12071	4630	90611718
Hyponatraemia	70.53	27.57	88	12011	133450	90482898
Respiratory acidosis	64.16	27.57	28	12071	8091	90608257
Drug ineffective	63.85	27.57	55	12044	1384243	89232105
Confusional state	60.01	27.57	148	11951	386057	90230291
Acute kidney injury	59.86	27.57	132	11967	320255	90296093
Mucosal erosion	59.51	27.57	18	12081	1827	90614521
Hypokalaemia	57.72	27.57	79	12020	131037	90485311
Hepatic cytolysis	57.32	27.57	41	12058	30875	90585473
Bradycardia	57.16	27.57	63	12036	83784	90532564
Pancreatic failure	54.39	27.57	16	12083	1476	90614872
Mydriasis	53.22	27.57	30	12069	14982	90601366
Lactic acidosis	53.06	27.57	48	12051	50415	90565933
Bradykinesia	52.31	27.57	23	12076	6765	90609583
Abdominal discomfort	51.71	27.57	3	12096	477325	90139023
Hypotonia neonatal	50.66	27.57	15	12084	1415	90614933
Renal failure	50.36	27.57	74	12025	130933	90485415
Pain	50.36	27.57	36	12063	996305	89620043
Rash	49.93	27.57	22	12077	796078	89820270
Metabolic acidosis	49.04	27.57	48	12051	55628	90560720
Substance abuse	47.17	27.57	20	12079	5386	90610962
Hypotonia	46.46	27.57	25	12074	11401	90604947
Victim of sexual abuse	46.45	27.57	12	12087	683	90615665
Neuroleptic malignant syndrome	45.11	27.57	27	12072	15069	90601279
Disorientation	44.50	27.57	41	12058	44073	90572275
Thymus disorder	44.30	27.57	10	12089	320	90616028
Drug intolerance	42.47	27.57	5	12094	447586	90168762
Eyelid myoclonus	41.86	27.57	8	12091	110	90616238
Alkalosis hypochloraemic	41.63	27.57	9	12090	235	90616113
Genital erosion	40.93	27.57	10	12089	453	90615895
Hepatic perfusion disorder	39.44	27.57	7	12092	62	90616286
Wrong patient	39.34	27.57	11	12088	846	90615502
Fatigue	38.81	27.57	59	12040	1153964	89462384
Hypoglycaemia	38.41	27.57	47	12052	69801	90546547
Hypergammaglobulinaemia	38.01	27.57	10	12089	611	90615737
Drug hypersensitivity	37.65	27.57	8	12091	463601	90152747
Neurological examination abnormal	37.61	27.57	9	12090	373	90615975
Sinus bradycardia	37.34	27.57	25	12074	16927	90599421
Hepatic enzyme increased	36.92	27.57	3	12096	360733	90255615
Eosinophilic pustular folliculitis	36.64	27.57	7	12092	96	90616252
Haemodynamic instability	35.08	27.57	21	12078	11718	90604630
Accidental exposure to product by child	34.55	27.57	11	12088	1322	90615026
Single umbilical artery	33.54	27.57	8	12091	327	90616021
Anterograde amnesia	33.45	27.57	9	12090	600	90615748
Hepatocellular injury	33.33	27.57	29	12070	28929	90587419
Cataplexy	33.13	27.57	11	12088	1509	90614839
Neutrophil toxic granulation present	32.79	27.57	7	12092	172	90616176
Mouth ulceration	32.49	27.57	33	12066	39941	90576407
Hyperthermia	32.22	27.57	19	12080	10316	90606032
Infection	32.07	27.57	5	12094	362089	90254259
Hyperammonaemia	31.57	27.57	16	12083	6459	90609889
Cardiogenic shock	31.22	27.57	26	12073	24442	90591906
Intentional self-injury	31.02	27.57	28	12071	29306	90587042
Cognitive disorder	30.79	27.57	42	12057	69365	90546983
Vertigo	30.60	27.57	42	12057	69769	90546579
Toxic epidermal necrolysis	30.43	27.57	29	12070	32499	90583849
Psychomotor retardation	29.86	27.57	14	12085	4775	90611573
Genital infection female	29.72	27.57	6	12093	111	90616237
Cholestatic liver injury	29.69	27.57	13	12086	3784	90612564
Shock	29.51	27.57	27	12072	28751	90587597
Hepatitis fulminant	29.21	27.57	13	12086	3932	90612416
Weight increased	28.69	27.57	10	12089	417917	90198431
Hypoaesthesia	28.61	27.57	4	12095	314206	90302142

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	505.28	23.46	222	6827	53332	42560954
Drug use disorder	325.74	23.46	104	6945	10229	42604057
Drug abuse	308.92	23.46	200	6849	104571	42509715
Miosis	231.07	23.46	86	6963	13360	42600926
Substance use disorder	136.82	23.46	46	7003	5299	42608987
Drug dependence	136.15	23.46	75	6974	29019	42585267
Intentional overdose	126.54	23.46	88	6961	51368	42562918
Poisoning deliberate	121.62	23.46	50	6999	10084	42604202
Somnolence	120.91	23.46	132	6917	140973	42473313
Sopor	96.52	23.46	46	7003	13156	42601130
Toxicity to various agents	77.66	23.46	137	6912	228999	42385287
Serotonin syndrome	74.94	23.46	49	7000	25796	42588490
Drug interaction	66.36	23.46	140	6909	266859	42347427
Overdose	58.16	23.46	79	6970	105185	42509101
Suicide attempt	53.68	23.46	51	6998	46049	42568237
Respiratory distress	52.03	23.46	48	7001	41772	42572514
Intentional self-injury	51.98	23.46	32	7017	15170	42599116
Respiratory depression	50.39	23.46	34	7015	18834	42595452
Self-injurious ideation	43.56	23.46	15	7034	1853	42612433
Pyramidal tract syndrome	42.92	23.46	10	7039	296	42613990
Poisoning	42.91	23.46	28	7021	14671	42599615
Drug ineffective	42.57	23.46	26	7023	630171	41984115
Toxic encephalopathy	41.18	23.46	21	7028	6932	42607354
Hypoventilation	39.70	23.46	17	7032	3785	42610501
Intentional product misuse	39.65	23.46	50	6999	61850	42552436
Mydriasis	39.30	23.46	22	7027	8748	42605538
Bradypnoea	37.34	23.46	17	7032	4376	42609910
Altered state of consciousness	35.25	23.46	33	7016	29226	42585060
Asphyxia	34.92	23.46	20	7029	8306	42605980
Respiratory acidosis	34.27	23.46	18	7031	6313	42607973
Rhabdomyolysis	32.10	23.46	51	6998	77968	42536318
Neuroleptic malignant syndrome	31.36	23.46	27	7022	21445	42592841
Hyperthermia	29.67	23.46	21	7028	12553	42601733
Confusional state	29.56	23.46	77	6972	167520	42446766
Pneumonia aspiration	28.24	23.46	38	7011	50040	42564246
Agitation	27.78	23.46	43	7006	64271	42550015
Prescription form tampering	27.07	23.46	8	7041	604	42613682
Self-destructive behaviour	25.97	23.46	7	7042	378	42613908
Blood triglycerides increased	25.29	23.46	21	7028	15875	42598411
Therapeutic hypothermia	25.29	23.46	4	7045	12	42614274
Hypothermia	25.21	23.46	19	7030	12496	42601790
Persecutory delusion	24.76	23.46	12	7037	3552	42610734
Multi-organ disorder	24.59	23.46	9	7040	1327	42612959
Withdrawal syndrome	24.51	23.46	20	7029	14755	42599531
Rash	23.95	23.46	8	7041	276946	42337340
Cardio-respiratory arrest	23.65	23.46	38	7011	58598	42555688
Circulatory collapse	23.49	23.46	24	7025	23612	42590674

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	1138.54	22.62	498	17907	117371	110453523
Drug abuse	788.26	22.62	442	17963	176969	110393925
Poisoning deliberate	577.25	22.62	202	18203	26129	110544765
Drug use disorder	483.49	22.62	161	18244	17913	110552981
Miosis	415.00	22.62	151	18254	21832	110549062
Somnolence	400.42	22.62	357	18048	297092	110273802
Intentional overdose	365.92	22.62	244	18161	132257	110438637
Sopor	324.64	22.62	146	18259	36400	110534494
Drug dependence	295.49	22.62	151	18254	49869	110521025
Toxicity to various agents	283.69	22.62	373	18032	480182	110090712
Drug interaction	234.96	22.62	348	18057	499835	110071059
Substance use disorder	219.27	22.62	71	18334	7219	110563675
Suicide attempt	214.54	22.62	160	18245	103234	110467660
Serotonin syndrome	180.29	22.62	116	18289	59037	110511857
Poisoning	175.11	22.62	89	18316	29016	110541878
Overdose	163.75	22.62	198	18207	233596	110337298
Depressed level of consciousness	147.06	22.62	133	18272	112145	110458749
Altered state of consciousness	134.94	22.62	96	18309	57530	110513364
Intentional product misuse	129.85	22.62	134	18271	132770	110438124
Rhabdomyolysis	115.09	22.62	120	18285	120281	110450613
Asphyxia	111.12	22.62	52	18353	14163	110556731
Drug ineffective	110.66	22.62	58	18347	1520482	109050412
Bradypnoea	107.97	22.62	44	18361	8605	110562289
Hypothermia	101.54	22.62	60	18345	26242	110544652
Pneumonia aspiration	100.04	22.62	93	18312	81140	110489754
Bradyphrenia	98.21	22.62	45	18360	11683	110559211
Respiratory acidosis	94.14	22.62	46	18359	13780	110557114
Hypotension	93.94	22.62	243	18162	523606	110047288
Mydriasis	89.36	22.62	52	18353	22105	110548789
Confusional state	87.72	22.62	221	18184	468459	110102435
Electrocardiogram QT prolonged	83.97	22.62	97	18308	108863	110462031
Intentional self-injury	79.95	22.62	59	18346	37370	110533524
Vasoplegia syndrome	79.47	22.62	31	18374	5408	110565486
Respiratory depression	74.17	22.62	53	18352	31948	110538946
Neuroleptic malignant syndrome	73.45	22.62	54	18351	34005	110536889
Fall	70.04	22.62	240	18165	603242	109967652
Hypokalaemia	67.37	22.62	114	18291	182334	110388560
Renal failure	61.52	22.62	124	18281	226450	110344444
Hyperthermia	60.56	22.62	40	18365	21232	110549662
Hyponatraemia	58.95	22.62	119	18286	217534	110353360
Rash	58.48	22.62	32	18373	820932	109749962
Hepatic cytolysis	58.26	22.62	58	18347	54995	110515899
Pain in extremity	57.07	22.62	7	18398	487111	110083783
Haemodynamic instability	55.56	22.62	39	18366	22849	110548045
Pain	53.80	22.62	48	18357	954907	109615987
Nasopharyngitis	53.48	22.62	3	18402	394358	110176536
Drug intolerance	49.74	22.62	5	18400	406507	110164387
Substance abuse	49.59	22.62	29	18376	12434	110558460
Hypersensitivity	49.35	22.62	5	18400	403993	110166901
Lactic acidosis	48.31	22.62	68	18337	92743	110478151
Mucosal erosion	48.10	22.62	18	18387	2806	110568088
Prescription form tampering	47.25	22.62	12	18393	509	110570385
Hyperglycaemia	46.77	22.62	64	18341	85026	110485868
Drug hypersensitivity	45.47	22.62	10	18395	454080	110116814
Pancreatic failure	43.75	22.62	16	18389	2338	110568556
Acute kidney injury	43.63	22.62	215	18190	635215	109935679
Bradykinesia	42.65	22.62	25	18380	10763	110560131
Victim of sexual abuse	41.99	22.62	11	18394	528	110570366
Arthralgia	41.73	22.62	41	18364	779591	109791303
Respiratory distress	41.21	22.62	54	18351	68820	110502074
Infusion related reaction	41.09	22.62	7	18398	381155	110189739
Withdrawal syndrome	40.69	22.62	37	18368	31343	110539551
Fatigue	40.61	22.62	89	18316	1215869	109355025
Persecutory delusion	40.05	22.62	20	18385	6271	110564623
Toxic encephalopathy	39.45	22.62	27	18378	15187	110555707
Cardiogenic shock	39.12	22.62	48	18357	57290	110513604
Metabolic acidosis	39.03	22.62	64	18341	99680	110471214
Parkinsonism	38.67	22.62	31	18374	22156	110548738
Weight increased	38.60	22.62	11	18394	419633	110151261
Eyelid myoclonus	38.51	22.62	8	18397	136	110570758
Tachycardia	38.30	22.62	103	18302	226542	110344352
Infection	38.29	22.62	7	18398	362193	110208701
Hepatic perfusion disorder	37.80	22.62	7	18398	63	110570831
Pneumonia	37.47	22.62	55	18350	876659	109694235
Disorientation	37.10	22.62	52	18353	70619	110500275
Sinus bradycardia	36.75	22.62	34	18371	29449	110541445
Anterograde amnesia	36.56	22.62	11	18394	877	110570017
Thymus disorder	36.40	22.62	10	18395	576	110570318
Hypotonia	36.30	22.62	26	18379	15719	110555175
Bradycardia	36.24	22.62	80	18325	155437	110415457
Hypoaesthesia	35.62	22.62	5	18400	314218	110256676
Wrong patient	34.73	22.62	12	18393	1487	110569407
Congestive cardiomyopathy	33.98	22.62	24	18381	14195	110556699
Neurological examination abnormal	33.65	22.62	10	18395	764	110570130
Cataplexy	33.58	22.62	11	18394	1158	110569736
Genital erosion	33.19	22.62	10	18395	801	110570093
Pyramidal tract syndrome	32.76	22.62	10	18395	837	110570057
Self-destructive behaviour	32.67	22.62	10	18395	845	110570049
Product dose omission issue	32.37	22.62	7	18398	321775	110249119
Urticaria	31.95	22.62	7	18398	318850	110252044
Eosinophilic pustular folliculitis	31.82	22.62	7	18398	158	110570736
Alkalosis hypochloraemic	31.60	22.62	9	18396	592	110570302
Hypergammaglobulinaemia	31.55	22.62	10	18395	948	110569946
Maternal exposure during pregnancy	31.52	22.62	3	18402	254880	110316014
Self-injurious ideation	31.21	22.62	15	18390	4331	110566563
Asthma	30.80	22.62	3	18402	250288	110320606
Agitation	30.80	22.62	62	18343	112989	110457905
Musculoskeletal stiffness	30.46	22.62	5	18400	279817	110291077
Cognitive disorder	30.07	22.62	53	18352	87458	110483436
Hypoventilation	30.05	22.62	18	18387	8063	110562831
Genital infection female	29.97	22.62	6	18399	84	110570810
Lower respiratory tract infection	29.69	22.62	3	18402	243103	110327791
Hepatocellular injury	29.20	22.62	39	18366	50603	110520291
Bladder dilatation	29.05	22.62	12	18393	2427	110568467
Neutrophil toxic granulation present	28.98	22.62	7	18398	241	110570653
Hepatic enzyme increased	28.43	22.62	9	18396	320883	110250011
Balance disorder	27.19	22.62	60	18345	116500	110454394
Mobility decreased	26.39	22.62	4	18401	237418	110333476
Cough	26.17	22.62	23	18382	461618	110109276
Cerebellar syndrome	25.96	22.62	15	18390	6287	110564607
Hyperammonaemia	25.68	22.62	20	18385	13712	110557182
Anticholinergic syndrome	25.47	22.62	13	18392	4267	110566627
Brain death	25.37	22.62	15	18390	6558	110564336
Loss of consciousness	25.28	22.62	81	18324	196225	110374669
Cardio-respiratory arrest	25.20	22.62	58	18347	115778	110455116
Lip erosion	25.03	22.62	10	18395	1856	110569038
Cholestasis	24.70	22.62	41	18364	64477	110506417
Vertigo	24.09	22.62	48	18357	86822	110484072
Hypoglycaemia	24.02	22.62	57	18348	116047	110454847
Drug reaction with eosinophilia and systemic symptoms	23.53	22.62	46	18359	82049	110488845
Dyspnoea	23.32	22.62	100	18305	1106772	109464122
White blood cell count decreased	23.04	22.62	5	18400	229385	110341509
Morbihan disease	23.03	22.62	4	18401	24	110570870
Product prescribing error	22.92	22.62	35	18370	51296	110519598
Accidental exposure to product by child	22.85	22.62	11	18394	3187	110567707
Hypomagnesaemia	22.62	22.62	38	18367	60332	110510562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CD06	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine derivatives
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35717	sedative

Related Drugs by ATC class:

N05CD Benzodiazepine derivatives 14 drugs

brotizolamcinolazepamdoxefazepamestazolamflunitrazepamflurazepamloprazolammidazolamnimetazepamnitrazepamquazepamremimazolam show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.75	acidic
pKa2	0.26	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01657	KEGG_DRUG
C0065185	UMLSCUI
CHEBI:52993	CHEBI
CHEMBL22097	ChEMBL_ID
DB13872	DRUGBANK_ID
C023842	MESH_SUPPLEMENTAL_RECORD_UI
13314	PUBCHEM_CID
7553	IUPHAR_LIGAND_ID
4339	INN_ID
GU56C842ZA	UNII
28894	RXNORM
004099	NDDF
387570005	SNOMEDCT_US
96233008	SNOMEDCT_US

Pharmaceutical products:

None