Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 1802 | 59467-70-8 |
Dose | Unit | Route |
---|---|---|
5 | mg | N |
15 | mg | O |
15 | mg | P |
10 | mg | SL |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10.30 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5.60 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.26 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 44 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 20, 1985 | FDA | ||
Sept. 25, 2020 | PMDA | TAKEDA PHARMACEUTICAL COMPANY LIMITED |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Status epilepticus | 271.44 | 14.44 | 130 | 23401 | 13276 | 50568317 |
Hypotension | 237.44 | 14.44 | 406 | 23125 | 235063 | 50346530 |
Multiple-drug resistance | 214.15 | 14.44 | 74 | 23457 | 3240 | 50578353 |
Cardiac arrest | 213.09 | 14.44 | 227 | 23304 | 83424 | 50498169 |
Serotonin syndrome | 204.49 | 14.44 | 133 | 23398 | 24580 | 50557013 |
Anaphylactic reaction | 190.21 | 14.44 | 175 | 23356 | 53880 | 50527713 |
Propofol infusion syndrome | 149.24 | 14.44 | 40 | 23491 | 726 | 50580867 |
Drug interaction | 137.48 | 14.44 | 293 | 23238 | 199328 | 50382265 |
Fatigue | 128.90 | 14.44 | 86 | 23445 | 707515 | 49874078 |
Diabetes insipidus | 115.80 | 14.44 | 43 | 23488 | 2321 | 50579272 |
Tachycardia | 114.94 | 14.44 | 183 | 23348 | 99580 | 50482013 |
Respiratory acidosis | 111.58 | 14.44 | 55 | 23476 | 5973 | 50575620 |
Labile blood pressure | 103.13 | 14.44 | 36 | 23495 | 1624 | 50579969 |
Metabolic acidosis | 99.85 | 14.44 | 106 | 23425 | 38719 | 50542874 |
Multiple organ dysfunction syndrome | 99.74 | 14.44 | 120 | 23411 | 50217 | 50531376 |
Drug ineffective | 99.25 | 14.44 | 684 | 22847 | 818649 | 49762944 |
Seizure | 97.68 | 14.44 | 187 | 23344 | 117687 | 50463906 |
Joint swelling | 96.91 | 14.44 | 4 | 23527 | 245282 | 50336311 |
Generalised tonic-clonic seizure | 96.02 | 14.44 | 87 | 23444 | 26223 | 50555370 |
Encephalopathy | 95.61 | 14.44 | 97 | 23434 | 33614 | 50547979 |
Myoglobin urine present | 93.44 | 14.44 | 24 | 23507 | 366 | 50581227 |
Drug ineffective for unapproved indication | 88.93 | 14.44 | 76 | 23455 | 21205 | 50560388 |
Circulatory collapse | 88.87 | 14.44 | 74 | 23457 | 19926 | 50561667 |
Agitation | 86.31 | 14.44 | 115 | 23416 | 53269 | 50528324 |
Anaphylactic shock | 86.31 | 14.44 | 73 | 23458 | 20082 | 50561511 |
Unwanted awareness during anaesthesia | 85.52 | 14.44 | 21 | 23510 | 264 | 50581329 |
Alopecia | 84.93 | 14.44 | 8 | 23523 | 245039 | 50336554 |
Toxic encephalopathy | 80.84 | 14.44 | 43 | 23488 | 5472 | 50576121 |
Intra-abdominal pressure increased | 80.46 | 14.44 | 19 | 23512 | 200 | 50581393 |
Pain | 80.17 | 14.44 | 91 | 23440 | 578812 | 50002781 |
Mitochondrial DNA mutation | 77.96 | 14.44 | 19 | 23512 | 231 | 50581362 |
Myoclonus | 75.89 | 14.44 | 59 | 23472 | 14411 | 50567182 |
Renal ischaemia | 75.04 | 14.44 | 22 | 23509 | 560 | 50581033 |
Abdominal discomfort | 74.15 | 14.44 | 10 | 23521 | 231631 | 50349962 |
Bradycardia | 73.89 | 14.44 | 118 | 23413 | 64308 | 50517285 |
Shock | 70.90 | 14.44 | 66 | 23465 | 20584 | 50561009 |
Oxygen saturation abnormal | 69.65 | 14.44 | 31 | 23500 | 2671 | 50578922 |
Swelling | 68.43 | 14.44 | 7 | 23524 | 200865 | 50380728 |
Pneumatosis | 67.69 | 14.44 | 19 | 23512 | 412 | 50581181 |
Intestinal ischaemia | 64.93 | 14.44 | 40 | 23491 | 6717 | 50574876 |
Delirium | 64.38 | 14.44 | 84 | 23447 | 38108 | 50543485 |
PCO2 increased | 64.20 | 14.44 | 23 | 23508 | 1120 | 50580473 |
Ventricular hypokinesia | 63.94 | 14.44 | 33 | 23498 | 3947 | 50577646 |
PO2 increased | 63.52 | 14.44 | 21 | 23510 | 801 | 50580792 |
Partial seizures | 63.15 | 14.44 | 35 | 23496 | 4830 | 50576763 |
Fall | 63.03 | 14.44 | 39 | 23492 | 334893 | 50246700 |
Arthralgia | 62.80 | 14.44 | 67 | 23464 | 438635 | 50142958 |
Unresponsive to stimuli | 62.30 | 14.44 | 74 | 23457 | 30535 | 50551058 |
Systemic inflammatory response syndrome | 61.94 | 14.44 | 35 | 23496 | 5014 | 50576579 |
Hepatic ischaemia | 61.33 | 14.44 | 19 | 23512 | 586 | 50581007 |
Arthropathy | 60.94 | 14.44 | 3 | 23528 | 157903 | 50423690 |
Off label use | 60.55 | 14.44 | 402 | 23129 | 474024 | 50107569 |
Nausea | 60.54 | 14.44 | 151 | 23380 | 705247 | 49876346 |
Drug intolerance | 60.26 | 14.44 | 14 | 23517 | 219090 | 50362503 |
Blood pH decreased | 59.57 | 14.44 | 27 | 23504 | 2428 | 50579165 |
Pulseless electrical activity | 59.46 | 14.44 | 38 | 23493 | 6803 | 50574790 |
Electrocardiogram QRS complex prolonged | 57.45 | 14.44 | 34 | 23497 | 5310 | 50576283 |
Delayed recovery from anaesthesia | 57.34 | 14.44 | 19 | 23512 | 730 | 50580863 |
Necrosis ischaemic | 56.14 | 14.44 | 19 | 23512 | 780 | 50580813 |
Respiratory failure | 55.98 | 14.44 | 128 | 23403 | 91053 | 50490540 |
Peripheral swelling | 54.98 | 14.44 | 14 | 23517 | 205922 | 50375671 |
Anaesthetic complication | 54.94 | 14.44 | 23 | 23508 | 1707 | 50579886 |
Anticholinergic syndrome | 54.12 | 14.44 | 23 | 23508 | 1772 | 50579821 |
Malaise | 54.10 | 14.44 | 46 | 23485 | 335486 | 50246107 |
Apnoea | 53.96 | 14.44 | 36 | 23495 | 6930 | 50574663 |
Pain in extremity | 53.82 | 14.44 | 30 | 23501 | 272835 | 50308758 |
Diarrhoea | 53.58 | 14.44 | 122 | 23409 | 588354 | 49993239 |
Foetal death | 53.29 | 14.44 | 38 | 23493 | 8142 | 50573451 |
Systemic lupus erythematosus | 53.23 | 14.44 | 3 | 23528 | 140619 | 50440974 |
Hepatic failure | 52.85 | 14.44 | 70 | 23461 | 32213 | 50549380 |
Perforation | 52.65 | 14.44 | 19 | 23512 | 945 | 50580648 |
Cardiogenic shock | 51.90 | 14.44 | 49 | 23482 | 15550 | 50566043 |
Neuromuscular block prolonged | 51.60 | 14.44 | 16 | 23515 | 495 | 50581098 |
Acute respiratory distress syndrome | 51.40 | 14.44 | 56 | 23475 | 21043 | 50560550 |
Respiratory depression | 50.39 | 14.44 | 43 | 23488 | 11967 | 50569626 |
Oropharyngeal oedema | 48.14 | 14.44 | 13 | 23518 | 243 | 50581350 |
Muscle relaxant therapy | 47.94 | 14.44 | 12 | 23519 | 164 | 50581429 |
Blood creatine phosphokinase increased | 47.59 | 14.44 | 60 | 23471 | 26307 | 50555286 |
Renal impairment | 47.31 | 14.44 | 107 | 23424 | 75554 | 50506039 |
Epileptic aura | 47.17 | 14.44 | 10 | 23521 | 61 | 50581532 |
Ventricular extrasystoles | 46.89 | 14.44 | 39 | 23492 | 10477 | 50571116 |
Nasopharyngitis | 46.24 | 14.44 | 16 | 23515 | 192911 | 50388682 |
Headache | 46.07 | 14.44 | 105 | 23426 | 506430 | 50075163 |
Electrocardiogram ST segment depression | 45.80 | 14.44 | 23 | 23508 | 2597 | 50578996 |
Epilepsy | 45.31 | 14.44 | 53 | 23478 | 21514 | 50560079 |
Oxygen saturation decreased | 45.14 | 14.44 | 103 | 23428 | 73145 | 50508448 |
Electrocardiogram ST segment elevation | 45.12 | 14.44 | 25 | 23506 | 3448 | 50578145 |
Blood bicarbonate decreased | 44.95 | 14.44 | 23 | 23508 | 2702 | 50578891 |
Anaesthetic complication pulmonary | 44.65 | 14.44 | 9 | 23522 | 41 | 50581552 |
Infusion related reaction | 44.35 | 14.44 | 12 | 23519 | 169545 | 50412048 |
Hypoxia | 43.38 | 14.44 | 82 | 23449 | 51041 | 50530552 |
Anorectal ulcer | 43.17 | 14.44 | 9 | 23522 | 50 | 50581543 |
Non-consummation | 42.72 | 14.44 | 9 | 23522 | 53 | 50581540 |
Mydriasis | 42.45 | 14.44 | 37 | 23494 | 10590 | 50571003 |
Electroencephalogram abnormal | 42.23 | 14.44 | 24 | 23507 | 3475 | 50578118 |
Cardiotoxicity | 42.03 | 14.44 | 31 | 23500 | 6996 | 50574597 |
Female genital tract fistula | 41.19 | 14.44 | 24 | 23507 | 3642 | 50577951 |
Product dose omission issue | 41.13 | 14.44 | 17 | 23514 | 183821 | 50397772 |
Diabetic macroangiopathy | 41.00 | 14.44 | 10 | 23521 | 122 | 50581471 |
Intestinal infarction | 40.90 | 14.44 | 16 | 23515 | 996 | 50580597 |
Blood gases abnormal | 40.24 | 14.44 | 14 | 23517 | 625 | 50580968 |
Toxicity to various agents | 40.05 | 14.44 | 200 | 23331 | 212299 | 50369294 |
Brain oedema | 39.52 | 14.44 | 38 | 23493 | 12332 | 50569261 |
Amylase increased | 39.52 | 14.44 | 27 | 23504 | 5403 | 50576190 |
Colitis | 39.34 | 14.44 | 67 | 23464 | 38462 | 50543131 |
Disseminated intravascular coagulation | 39.18 | 14.44 | 44 | 23487 | 17091 | 50564502 |
Bronchospasm | 38.95 | 14.44 | 41 | 23490 | 14813 | 50566780 |
Ultrasound ovary abnormal | 38.80 | 14.44 | 9 | 23522 | 87 | 50581506 |
Weight increased | 38.64 | 14.44 | 23 | 23508 | 201868 | 50379725 |
Hepatorenal syndrome | 38.63 | 14.44 | 18 | 23513 | 1725 | 50579868 |
Pseudopolyp | 38.62 | 14.44 | 11 | 23520 | 252 | 50581341 |
Altered state of consciousness | 38.18 | 14.44 | 49 | 23482 | 21861 | 50559732 |
Contraindicated product administered | 38.10 | 14.44 | 11 | 23520 | 148947 | 50432646 |
Upper airway obstruction | 37.81 | 14.44 | 13 | 23518 | 560 | 50581033 |
Sinusitis | 37.78 | 14.44 | 16 | 23515 | 170542 | 50411051 |
Unmasking of previously unidentified disease | 37.55 | 14.44 | 14 | 23517 | 764 | 50580829 |
Gene mutation | 37.37 | 14.44 | 16 | 23515 | 1255 | 50580338 |
Airway peak pressure increased | 37.37 | 14.44 | 11 | 23520 | 284 | 50581309 |
Stress cardiomyopathy | 36.73 | 14.44 | 30 | 23501 | 7857 | 50573736 |
Blood lactic acid increased | 36.51 | 14.44 | 26 | 23505 | 5559 | 50576034 |
Discomfort | 36.31 | 14.44 | 4 | 23527 | 108376 | 50473217 |
Troponin increased | 35.98 | 14.44 | 30 | 23501 | 8088 | 50573505 |
Systolic dysfunction | 35.12 | 14.44 | 16 | 23515 | 1456 | 50580137 |
Left ventricular dysfunction | 34.94 | 14.44 | 33 | 23498 | 10473 | 50571120 |
Acid base balance abnormal | 34.78 | 14.44 | 10 | 23521 | 237 | 50581356 |
Sinus bradycardia | 33.88 | 14.44 | 36 | 23495 | 13147 | 50568446 |
Laryngeal stenosis | 33.62 | 14.44 | 13 | 23518 | 784 | 50580809 |
Anaesthetic complication neurological | 32.99 | 14.44 | 9 | 23522 | 175 | 50581418 |
Acute coronary syndrome | 32.24 | 14.44 | 30 | 23501 | 9344 | 50572249 |
Haemodynamic instability | 32.18 | 14.44 | 28 | 23503 | 7996 | 50573597 |
Encephalitis autoimmune | 31.04 | 14.44 | 14 | 23517 | 1244 | 50580349 |
Proctitis | 31.01 | 14.44 | 16 | 23515 | 1912 | 50579681 |
Gastrointestinal scarring | 30.77 | 14.44 | 9 | 23522 | 227 | 50581366 |
Hyperammonaemic encephalopathy | 30.47 | 14.44 | 16 | 23515 | 1983 | 50579610 |
Hepatocellular injury | 30.38 | 14.44 | 48 | 23483 | 25899 | 50555694 |
Weight decreased | 30.24 | 14.44 | 35 | 23496 | 221210 | 50360383 |
Drug-induced liver injury | 30.20 | 14.44 | 50 | 23481 | 28045 | 50553548 |
Vaginal flatulence | 30.19 | 14.44 | 9 | 23522 | 243 | 50581350 |
Product use in unapproved indication | 30.09 | 14.44 | 120 | 23411 | 115699 | 50465894 |
Sinus tachycardia | 29.98 | 14.44 | 43 | 23488 | 21311 | 50560282 |
Bulimia nervosa | 29.86 | 14.44 | 10 | 23521 | 397 | 50581196 |
Tachyphylaxis | 29.78 | 14.44 | 9 | 23522 | 255 | 50581338 |
Dizziness | 29.67 | 14.44 | 74 | 23457 | 346295 | 50235298 |
Arthritis | 29.56 | 14.44 | 3 | 23528 | 86718 | 50494875 |
Hypernatraemia | 29.35 | 14.44 | 24 | 23507 | 6297 | 50575296 |
Drug resistance | 29.28 | 14.44 | 40 | 23491 | 18949 | 50562644 |
Macroglossia | 29.04 | 14.44 | 11 | 23520 | 627 | 50580966 |
Restlessness | 28.69 | 14.44 | 46 | 23485 | 25127 | 50556466 |
Paradoxical drug reaction | 28.61 | 14.44 | 19 | 23512 | 3628 | 50577965 |
Procedural vomiting | 28.54 | 14.44 | 10 | 23521 | 456 | 50581137 |
Musculoskeletal stiffness | 28.53 | 14.44 | 12 | 23519 | 128469 | 50453124 |
Lower respiratory tract infection | 28.40 | 14.44 | 5 | 23526 | 95196 | 50486397 |
Gastrointestinal mucosa hyperaemia | 28.22 | 14.44 | 8 | 23523 | 180 | 50581413 |
Hyperaesthesia | 27.81 | 14.44 | 26 | 23505 | 8147 | 50573446 |
Myoglobin blood increased | 27.56 | 14.44 | 13 | 23518 | 1280 | 50580313 |
Muscle rigidity | 27.34 | 14.44 | 28 | 23503 | 9801 | 50571792 |
Pituitary apoplexy | 26.77 | 14.44 | 7 | 23524 | 115 | 50581478 |
Acute respiratory failure | 26.71 | 14.44 | 48 | 23483 | 28734 | 50552859 |
Arrhythmia | 26.69 | 14.44 | 52 | 23479 | 33080 | 50548513 |
Rash | 26.60 | 14.44 | 109 | 23422 | 437362 | 50144231 |
Carcinoid crisis | 26.59 | 14.44 | 8 | 23523 | 223 | 50581370 |
Depressed level of consciousness | 26.57 | 14.44 | 68 | 23463 | 51885 | 50529708 |
Exposure during pregnancy | 26.48 | 14.44 | 119 | 23412 | 120896 | 50460697 |
Product administered to patient of inappropriate age | 26.37 | 14.44 | 16 | 23515 | 2614 | 50578979 |
Procedural hypotension | 26.36 | 14.44 | 12 | 23519 | 1090 | 50580503 |
Clonus | 26.29 | 14.44 | 19 | 23512 | 4156 | 50577437 |
Dyschezia | 26.25 | 14.44 | 14 | 23517 | 1790 | 50579803 |
Left ventricular hypertrophy | 25.93 | 14.44 | 20 | 23511 | 4825 | 50576768 |
Oliguria | 25.79 | 14.44 | 25 | 23506 | 8191 | 50573402 |
Back pain | 25.78 | 14.44 | 39 | 23492 | 219991 | 50361602 |
Contusion | 25.68 | 14.44 | 10 | 23521 | 112173 | 50469420 |
Frequent bowel movements | 25.63 | 14.44 | 32 | 23499 | 13886 | 50567707 |
Ventricular tachycardia | 25.42 | 14.44 | 34 | 23497 | 15787 | 50565806 |
Delayed graft function | 25.03 | 14.44 | 11 | 23520 | 919 | 50580674 |
Infection parasitic | 24.28 | 14.44 | 8 | 23523 | 302 | 50581291 |
Myalgia | 24.00 | 14.44 | 14 | 23517 | 124305 | 50457288 |
Asthma | 23.96 | 14.44 | 6 | 23525 | 89331 | 50492262 |
Premature delivery | 23.95 | 14.44 | 41 | 23490 | 23622 | 50557971 |
Asthenia | 23.71 | 14.44 | 73 | 23458 | 318969 | 50262624 |
Acidosis hyperchloraemic | 23.60 | 14.44 | 8 | 23523 | 330 | 50581263 |
Drug reaction with eosinophilia and systemic symptoms | 23.37 | 14.44 | 45 | 23486 | 28379 | 50553214 |
Patent ductus arteriosus | 23.18 | 14.44 | 17 | 23514 | 3803 | 50577790 |
Nail dystrophy | 23.16 | 14.44 | 10 | 23521 | 801 | 50580792 |
Cardio-respiratory arrest | 23.01 | 14.44 | 66 | 23465 | 53826 | 50527767 |
Tachypnoea | 22.92 | 14.44 | 31 | 23500 | 14546 | 50567047 |
Atrioventricular dissociation | 22.50 | 14.44 | 7 | 23524 | 219 | 50581374 |
Mixed liver injury | 22.40 | 14.44 | 16 | 23515 | 3435 | 50578158 |
Intensive care unit delirium | 22.40 | 14.44 | 5 | 23526 | 40 | 50581553 |
Electrocardiogram repolarisation abnormality | 22.36 | 14.44 | 11 | 23520 | 1189 | 50580404 |
Palpitations | 22.34 | 14.44 | 8 | 23523 | 94498 | 50487095 |
Tonic clonic movements | 22.04 | 14.44 | 11 | 23520 | 1226 | 50580367 |
Abdominal pain upper | 21.97 | 14.44 | 25 | 23506 | 159284 | 50422309 |
Methaemoglobinaemia | 21.97 | 14.44 | 13 | 23518 | 2029 | 50579564 |
Myocardial ischaemia | 21.87 | 14.44 | 27 | 23504 | 11586 | 50570007 |
White matter lesion | 21.82 | 14.44 | 12 | 23519 | 1630 | 50579963 |
Overdose | 21.76 | 14.44 | 98 | 23433 | 99629 | 50481964 |
Procedural complication | 21.74 | 14.44 | 18 | 23513 | 4805 | 50576788 |
Hypersensitivity | 21.67 | 14.44 | 42 | 23489 | 215119 | 50366474 |
Intentional overdose | 21.52 | 14.44 | 71 | 23460 | 62433 | 50519160 |
Apnoeic attack | 21.40 | 14.44 | 7 | 23524 | 258 | 50581335 |
Nephrocalcinosis | 21.40 | 14.44 | 10 | 23521 | 964 | 50580629 |
Blood lactate dehydrogenase increased | 21.27 | 14.44 | 35 | 23496 | 19527 | 50562066 |
Intensive care unit acquired weakness | 21.24 | 14.44 | 9 | 23522 | 688 | 50580905 |
Bronchitis | 21.16 | 14.44 | 11 | 23520 | 104148 | 50477445 |
Neurotoxicity | 21.16 | 14.44 | 30 | 23501 | 14710 | 50566883 |
Paralysis | 21.10 | 14.44 | 23 | 23508 | 8641 | 50572952 |
Laryngospasm | 21.08 | 14.44 | 14 | 23517 | 2674 | 50578919 |
Anuria | 20.94 | 14.44 | 26 | 23505 | 11218 | 50570375 |
Post procedural stroke | 20.89 | 14.44 | 5 | 23526 | 56 | 50581537 |
Granulomatous liver disease | 20.69 | 14.44 | 9 | 23522 | 734 | 50580859 |
Hypoventilation | 20.58 | 14.44 | 16 | 23515 | 3905 | 50577688 |
Haematemesis | 20.52 | 14.44 | 42 | 23489 | 27683 | 50553910 |
Therapeutic product effect prolonged | 20.26 | 14.44 | 7 | 23524 | 306 | 50581287 |
Impaired healing | 20.09 | 14.44 | 4 | 23527 | 69782 | 50511811 |
C-reactive protein decreased | 20.02 | 14.44 | 9 | 23522 | 794 | 50580799 |
Pulmonary oedema | 19.99 | 14.44 | 59 | 23472 | 48879 | 50532714 |
Euthyroid sick syndrome | 19.93 | 14.44 | 5 | 23526 | 69 | 50581524 |
Hypoaesthesia | 19.79 | 14.44 | 18 | 23513 | 127239 | 50454354 |
Psoriasis | 19.77 | 14.44 | 4 | 23527 | 68996 | 50512597 |
Coronary artery embolism | 19.69 | 14.44 | 6 | 23525 | 175 | 50581418 |
Blood magnesium decreased | 19.51 | 14.44 | 25 | 23506 | 11135 | 50570458 |
Hypovolaemia | 19.44 | 14.44 | 23 | 23508 | 9442 | 50572151 |
Posterior reversible encephalopathy syndrome | 19.42 | 14.44 | 29 | 23502 | 14899 | 50566694 |
Large intestinal ulcer | 19.40 | 14.44 | 14 | 23517 | 3055 | 50578538 |
Tonsillar hypertrophy | 19.37 | 14.44 | 9 | 23522 | 857 | 50580736 |
Immunosuppressant drug level increased | 19.35 | 14.44 | 14 | 23517 | 3068 | 50578525 |
Pneumonia fungal | 19.21 | 14.44 | 16 | 23515 | 4304 | 50577289 |
Hypochloraemia | 19.08 | 14.44 | 11 | 23520 | 1636 | 50579957 |
Intermittent claudication | 19.03 | 14.44 | 11 | 23520 | 1644 | 50579949 |
Ventricular dysfunction | 18.99 | 14.44 | 13 | 23518 | 2608 | 50578985 |
Local anaesthetic systemic toxicity | 18.98 | 14.44 | 8 | 23523 | 604 | 50580989 |
Neonatal seizure | 18.90 | 14.44 | 7 | 23524 | 375 | 50581218 |
Septic shock | 18.84 | 14.44 | 64 | 23467 | 57111 | 50524482 |
Airway complication of anaesthesia | 18.78 | 14.44 | 6 | 23525 | 205 | 50581388 |
Sinus arrest | 18.77 | 14.44 | 11 | 23520 | 1687 | 50579906 |
Stevens-Johnson syndrome | 18.58 | 14.44 | 35 | 23496 | 21717 | 50559876 |
Hepatic enzyme increased | 18.47 | 14.44 | 22 | 23509 | 137358 | 50444235 |
Hypertrophic cardiomyopathy | 18.35 | 14.44 | 10 | 23521 | 1335 | 50580258 |
Acute hepatic failure | 18.34 | 14.44 | 29 | 23502 | 15648 | 50565945 |
Symptom masked | 18.29 | 14.44 | 8 | 23523 | 661 | 50580932 |
Renal infarct | 18.24 | 14.44 | 10 | 23521 | 1350 | 50580243 |
Colitis ulcerative | 18.12 | 14.44 | 30 | 23501 | 16824 | 50564769 |
Coronary artery bypass | 18.12 | 14.44 | 12 | 23519 | 2281 | 50579312 |
Burkholderia test positive | 18.02 | 14.44 | 6 | 23525 | 234 | 50581359 |
Selective eating disorder | 17.99 | 14.44 | 11 | 23520 | 1821 | 50579772 |
Hyperammonaemia | 17.97 | 14.44 | 16 | 23515 | 4708 | 50576885 |
Resuscitation | 17.96 | 14.44 | 9 | 23522 | 1012 | 50580581 |
Pseudomonas infection | 17.88 | 14.44 | 22 | 23509 | 9408 | 50572185 |
Device related sepsis | 17.85 | 14.44 | 14 | 23517 | 3461 | 50578132 |
Gastrointestinal vascular malformation | 17.71 | 14.44 | 4 | 23527 | 34 | 50581559 |
Respiratory rate increased | 17.58 | 14.44 | 24 | 23507 | 11361 | 50570232 |
Extremity necrosis | 17.51 | 14.44 | 10 | 23521 | 1461 | 50580132 |
Foetal exposure during pregnancy | 17.43 | 14.44 | 39 | 23492 | 27320 | 50554273 |
Stomatitis | 17.41 | 14.44 | 13 | 23518 | 101331 | 50480262 |
Blood potassium increased | 17.38 | 14.44 | 29 | 23502 | 16369 | 50565224 |
Musculoskeletal pain | 17.25 | 14.44 | 6 | 23525 | 72171 | 50509422 |
Epileptic encephalopathy | 17.20 | 14.44 | 6 | 23525 | 270 | 50581323 |
Post procedural haemorrhage | 17.19 | 14.44 | 19 | 23512 | 7251 | 50574342 |
Influenza like illness | 17.17 | 14.44 | 3 | 23528 | 57456 | 50524137 |
Hypotonia | 17.10 | 14.44 | 20 | 23511 | 8114 | 50573479 |
Electrocardiogram QT prolonged | 17.02 | 14.44 | 58 | 23473 | 51828 | 50529765 |
Injection site pain | 16.91 | 14.44 | 16 | 23515 | 111008 | 50470585 |
Neuromuscular blockade | 16.91 | 14.44 | 6 | 23525 | 284 | 50581309 |
Teratoma | 16.88 | 14.44 | 5 | 23526 | 132 | 50581461 |
Axillary pain | 16.82 | 14.44 | 10 | 23521 | 1574 | 50580019 |
Coagulopathy | 16.74 | 14.44 | 30 | 23501 | 17914 | 50563679 |
Oral candidiasis | 16.72 | 14.44 | 29 | 23502 | 16886 | 50564707 |
Hypokalaemia | 16.66 | 14.44 | 83 | 23448 | 87909 | 50493684 |
Tracheal injury | 16.62 | 14.44 | 4 | 23527 | 46 | 50581547 |
Drug chemical incompatibility | 16.54 | 14.44 | 4 | 23527 | 47 | 50581546 |
Loss of personal independence in daily activities | 16.44 | 14.44 | 6 | 23525 | 70044 | 50511549 |
Vulvovaginal candidiasis | 16.38 | 14.44 | 12 | 23519 | 2680 | 50578913 |
Anaphylactoid shock | 16.37 | 14.44 | 6 | 23525 | 312 | 50581281 |
Hyperthermia | 16.30 | 14.44 | 19 | 23512 | 7677 | 50573916 |
Infantile apnoea | 16.26 | 14.44 | 8 | 23523 | 865 | 50580728 |
Wrong product administered | 16.25 | 14.44 | 16 | 23515 | 5344 | 50576249 |
Blood cholesterol increased | 16.25 | 14.44 | 3 | 23528 | 55212 | 50526381 |
Gait disturbance | 16.23 | 14.44 | 28 | 23503 | 149977 | 50431616 |
Procedural intestinal perforation | 16.18 | 14.44 | 5 | 23526 | 153 | 50581440 |
Ill-defined disorder | 16.01 | 14.44 | 3 | 23528 | 54651 | 50526942 |
Catheter site haemorrhage | 15.92 | 14.44 | 12 | 23519 | 2798 | 50578795 |
Sepsis | 15.85 | 14.44 | 111 | 23420 | 132814 | 50448779 |
Rash morbilliform | 15.78 | 14.44 | 12 | 23519 | 2834 | 50578759 |
Enzyme induction | 15.76 | 14.44 | 4 | 23527 | 58 | 50581535 |
Manipulation | 15.76 | 14.44 | 4 | 23527 | 58 | 50581535 |
Gaze palsy | 15.70 | 14.44 | 9 | 23522 | 1324 | 50580269 |
Coma hepatic | 15.66 | 14.44 | 7 | 23524 | 609 | 50580984 |
Oxygen saturation immeasurable | 15.63 | 14.44 | 3 | 23528 | 10 | 50581583 |
Radiculopathy | 15.44 | 14.44 | 15 | 23516 | 4926 | 50576667 |
Urinary tract infection | 15.41 | 14.44 | 53 | 23478 | 223967 | 50357626 |
White blood cell count decreased | 15.36 | 14.44 | 19 | 23512 | 116703 | 50464890 |
Dyspnoea | 15.30 | 14.44 | 172 | 23359 | 547436 | 50034157 |
Cor pulmonale | 15.21 | 14.44 | 10 | 23521 | 1877 | 50579716 |
Respiratory arrest | 15.05 | 14.44 | 39 | 23492 | 29970 | 50551623 |
Premature baby | 15.04 | 14.44 | 29 | 23502 | 18308 | 50563285 |
Coma | 14.81 | 14.44 | 59 | 23472 | 56820 | 50524773 |
Influenza | 14.73 | 14.44 | 12 | 23519 | 89526 | 50492067 |
Pruritus | 14.61 | 14.44 | 75 | 23456 | 283493 | 50298100 |
Therapeutic product effect variable | 14.58 | 14.44 | 8 | 23523 | 1082 | 50580511 |
Fear | 14.45 | 14.44 | 25 | 23506 | 14524 | 50567069 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Status epilepticus | 216.04 | 14.24 | 123 | 22846 | 10671 | 29540887 |
Drug ineffective | 160.20 | 14.24 | 629 | 22340 | 362541 | 29189017 |
Hypotension | 153.12 | 14.24 | 411 | 22558 | 193943 | 29357615 |
Drug reaction with eosinophilia and systemic symptoms | 148.43 | 14.24 | 143 | 22826 | 27849 | 29523709 |
Hyperthermia malignant | 141.59 | 14.24 | 53 | 22916 | 1731 | 29549827 |
Anaphylactic reaction | 140.83 | 14.24 | 138 | 22831 | 27435 | 29524123 |
Cardiac arrest | 139.15 | 14.24 | 243 | 22726 | 85348 | 29466210 |
Bradycardia | 133.20 | 14.24 | 206 | 22763 | 65423 | 29486135 |
Serotonin syndrome | 119.31 | 14.24 | 103 | 22866 | 17409 | 29534149 |
Multiple-drug resistance | 110.45 | 14.24 | 56 | 22913 | 3844 | 29547714 |
Propofol infusion syndrome | 102.43 | 14.24 | 34 | 22935 | 773 | 29550785 |
Intensive care unit acquired weakness | 97.24 | 14.24 | 34 | 22935 | 909 | 29550649 |
Myoclonus | 92.11 | 14.24 | 79 | 22890 | 13230 | 29538328 |
Fatigue | 91.30 | 14.24 | 68 | 22901 | 316753 | 29234805 |
Delirium | 87.43 | 14.24 | 129 | 22840 | 39268 | 29512290 |
Metabolic acidosis | 86.00 | 14.24 | 125 | 22844 | 37537 | 29514021 |
Drug ineffective for unapproved indication | 83.70 | 14.24 | 77 | 22892 | 14137 | 29537421 |
Anaphylactic shock | 81.96 | 14.24 | 74 | 22895 | 13262 | 29538296 |
Respiratory failure | 79.81 | 14.24 | 209 | 22760 | 96922 | 29454636 |
Diarrhoea | 71.99 | 14.24 | 92 | 22877 | 332606 | 29218952 |
Coma | 71.92 | 14.24 | 118 | 22851 | 39332 | 29512226 |
Off label use | 71.20 | 14.24 | 437 | 22532 | 300363 | 29251195 |
Dizziness | 69.88 | 14.24 | 30 | 22939 | 189654 | 29361904 |
Respiratory depression | 67.73 | 14.24 | 67 | 22902 | 13456 | 29538102 |
Autonomic nervous system imbalance | 66.93 | 14.24 | 34 | 22935 | 2342 | 29549216 |
Diabetes insipidus | 66.16 | 14.24 | 34 | 22935 | 2400 | 29549158 |
Tachycardia | 65.88 | 14.24 | 162 | 22807 | 72248 | 29479310 |
Acute respiratory distress syndrome | 61.10 | 14.24 | 82 | 22887 | 22853 | 29528705 |
Hypoxia | 58.80 | 14.24 | 120 | 22849 | 47259 | 29504299 |
Brain oedema | 58.35 | 14.24 | 59 | 22910 | 12161 | 29539397 |
Multiple organ dysfunction syndrome | 58.24 | 14.24 | 142 | 22827 | 62974 | 29488584 |
Rhabdomyolysis | 57.38 | 14.24 | 138 | 22831 | 60670 | 29490888 |
Acidosis hyperchloraemic | 56.72 | 14.24 | 18 | 22951 | 353 | 29551205 |
Generalised tonic-clonic seizure | 56.53 | 14.24 | 72 | 22897 | 19067 | 29532491 |
Product dose omission issue | 56.43 | 14.24 | 5 | 22964 | 96378 | 29455180 |
Sedation | 53.83 | 14.24 | 67 | 22902 | 17338 | 29534220 |
Depressed level of consciousness | 53.66 | 14.24 | 100 | 22869 | 36842 | 29514716 |
COVID-19 pneumonia | 52.99 | 14.24 | 50 | 22919 | 9472 | 29542086 |
Septic shock | 52.74 | 14.24 | 136 | 22833 | 62424 | 29489134 |
Drug interaction | 52.51 | 14.24 | 296 | 22673 | 197089 | 29354469 |
Unresponsive to stimuli | 52.47 | 14.24 | 80 | 22889 | 25046 | 29526512 |
Delayed recovery from anaesthesia | 52.03 | 14.24 | 20 | 22949 | 703 | 29550855 |
Headache | 51.74 | 14.24 | 36 | 22933 | 173971 | 29377587 |
Seizure like phenomena | 51.14 | 14.24 | 19 | 22950 | 607 | 29550951 |
Anaesthetic complication neurological | 50.65 | 14.24 | 16 | 22953 | 309 | 29551249 |
Agitation | 50.09 | 14.24 | 118 | 22851 | 51186 | 29500372 |
Nausea | 50.01 | 14.24 | 93 | 22876 | 289162 | 29262396 |
Necrosis ischaemic | 46.77 | 14.24 | 14 | 22955 | 224 | 29551334 |
Hyperthermia | 45.88 | 14.24 | 46 | 22923 | 9384 | 29542174 |
Respiratory acidosis | 45.76 | 14.24 | 33 | 22936 | 4295 | 29547263 |
Catatonia | 44.82 | 14.24 | 33 | 22936 | 4435 | 29547123 |
Anaesthetic complication | 42.79 | 14.24 | 19 | 22950 | 967 | 29550591 |
Haemodynamic instability | 42.29 | 14.24 | 41 | 22928 | 8032 | 29543526 |
Hypertransaminasaemia | 41.60 | 14.24 | 29 | 22940 | 3577 | 29547981 |
Shock | 40.31 | 14.24 | 65 | 22904 | 21339 | 29530219 |
Arthralgia | 40.02 | 14.24 | 30 | 22939 | 139587 | 29411971 |
Hyperammonaemia | 39.95 | 14.24 | 34 | 22935 | 5629 | 29545929 |
Sedation complication | 38.03 | 14.24 | 19 | 22950 | 1263 | 29550295 |
Long QT syndrome | 37.96 | 14.24 | 23 | 22946 | 2235 | 29549323 |
Laryngospasm | 37.92 | 14.24 | 19 | 22950 | 1271 | 29550287 |
Toxicity to various agents | 37.60 | 14.24 | 247 | 22722 | 173414 | 29378144 |
Fall | 37.16 | 14.24 | 50 | 22919 | 177128 | 29374430 |
Product administered to patient of inappropriate age | 36.98 | 14.24 | 24 | 22945 | 2631 | 29548927 |
Pain in extremity | 36.74 | 14.24 | 20 | 22949 | 110413 | 29441145 |
Stress cardiomyopathy | 36.54 | 14.24 | 20 | 22949 | 1604 | 29549954 |
Seizure | 36.40 | 14.24 | 156 | 22813 | 92967 | 29458591 |
Burkholderia test positive | 36.26 | 14.24 | 17 | 22952 | 982 | 29550576 |
Pulseless electrical activity | 36.21 | 14.24 | 34 | 22935 | 6400 | 29545158 |
Myalgia | 35.80 | 14.24 | 7 | 22962 | 74012 | 29477546 |
Herpes simplex viraemia | 35.73 | 14.24 | 9 | 22960 | 72 | 29551486 |
Asthenia | 35.58 | 14.24 | 71 | 22898 | 215179 | 29336379 |
Peripheral swelling | 35.49 | 14.24 | 4 | 22965 | 63735 | 29487823 |
Mucosal ulceration | 35.00 | 14.24 | 16 | 22953 | 872 | 29550686 |
Electroencephalogram abnormal | 34.73 | 14.24 | 22 | 22947 | 2313 | 29549245 |
Coagulopathy | 34.56 | 14.24 | 55 | 22914 | 17852 | 29533706 |
Kounis syndrome | 34.32 | 14.24 | 20 | 22949 | 1809 | 29549749 |
Artery dissection | 33.68 | 14.24 | 9 | 22960 | 93 | 29551465 |
Pruritus | 33.61 | 14.24 | 25 | 22944 | 116824 | 29434734 |
Corneal reflex decreased | 33.47 | 14.24 | 10 | 22959 | 159 | 29551399 |
Toxic epidermal necrolysis | 32.65 | 14.24 | 54 | 22915 | 18099 | 29533459 |
Apnoea | 31.98 | 14.24 | 31 | 22938 | 6071 | 29545487 |
Rash maculo-papular | 31.88 | 14.24 | 63 | 22906 | 24226 | 29527332 |
Dyspnoea | 31.38 | 14.24 | 139 | 22830 | 326593 | 29224965 |
Intestinal ischaemia | 31.38 | 14.24 | 32 | 22937 | 6660 | 29544898 |
Dyskinesia | 31.26 | 14.24 | 56 | 22913 | 20005 | 29531553 |
Back pain | 30.57 | 14.24 | 21 | 22948 | 102263 | 29449295 |
Cardiogenic shock | 30.46 | 14.24 | 54 | 22915 | 19136 | 29532422 |
Hypercapnia | 29.68 | 14.24 | 24 | 22945 | 3702 | 29547856 |
Blood lactic acid increased | 29.67 | 14.24 | 29 | 22940 | 5737 | 29545821 |
Death | 29.65 | 14.24 | 151 | 22818 | 341933 | 29209625 |
Respiratory arrest | 29.19 | 14.24 | 63 | 22906 | 25770 | 29525788 |
Circulatory collapse | 28.93 | 14.24 | 52 | 22917 | 18621 | 29532937 |
Trigemino-cardiac reflex | 28.67 | 14.24 | 9 | 22960 | 170 | 29551388 |
Haemophagocytic lymphohistiocytosis | 28.64 | 14.24 | 38 | 22931 | 10466 | 29541092 |
Behaviour disorder | 28.18 | 14.24 | 23 | 22946 | 3593 | 29547965 |
Post procedural hypotension | 27.68 | 14.24 | 7 | 22962 | 57 | 29551501 |
Superinfection | 27.65 | 14.24 | 18 | 22951 | 1983 | 29549575 |
Dehydration | 27.64 | 14.24 | 29 | 22940 | 114719 | 29436839 |
Myocardial infarction | 27.56 | 14.24 | 27 | 22942 | 110269 | 29441289 |
Neuromuscular block prolonged | 26.99 | 14.24 | 11 | 22958 | 452 | 29551106 |
Anticonvulsant drug level below therapeutic | 26.93 | 14.24 | 12 | 22957 | 616 | 29550942 |
Intracranial pressure increased | 26.81 | 14.24 | 22 | 22947 | 3463 | 29548095 |
Oxygen saturation decreased | 26.52 | 14.24 | 86 | 22883 | 44851 | 29506707 |
Malignant catatonia | 26.42 | 14.24 | 9 | 22960 | 222 | 29551336 |
Intensive care | 26.03 | 14.24 | 10 | 22959 | 351 | 29551207 |
Muscle rigidity | 25.59 | 14.24 | 34 | 22935 | 9377 | 29542181 |
Ventricular tachycardia | 25.44 | 14.24 | 55 | 22914 | 22519 | 29529039 |
Neuroleptic malignant syndrome | 25.06 | 14.24 | 45 | 22924 | 16103 | 29535455 |
Odynophagia | 24.99 | 14.24 | 24 | 22945 | 4646 | 29546912 |
Drug resistance | 24.88 | 14.24 | 53 | 22916 | 21487 | 29530071 |
Acidosis | 24.77 | 14.24 | 34 | 22935 | 9671 | 29541887 |
Overdose | 24.74 | 14.24 | 125 | 22844 | 79694 | 29471864 |
Liver function test | 24.53 | 14.24 | 6 | 22963 | 42 | 29551516 |
Nasopharyngitis | 24.32 | 14.24 | 8 | 22961 | 59657 | 29491901 |
Abdominal discomfort | 24.31 | 14.24 | 4 | 22965 | 47899 | 29503659 |
Hepatitis fulminant | 24.29 | 14.24 | 21 | 22948 | 3550 | 29548008 |
Hypoventilation | 24.12 | 14.24 | 19 | 22950 | 2822 | 29548736 |
Upper airway obstruction | 23.97 | 14.24 | 11 | 22958 | 605 | 29550953 |
Laryngomalacia | 23.75 | 14.24 | 9 | 22960 | 304 | 29551254 |
Leukocytosis | 23.25 | 14.24 | 51 | 22918 | 21091 | 29530467 |
Hyperammonaemic encephalopathy | 22.95 | 14.24 | 16 | 22953 | 1974 | 29549584 |
Drug withdrawal syndrome | 22.82 | 14.24 | 46 | 22923 | 17938 | 29533620 |
Large intestine anastomosis | 22.81 | 14.24 | 6 | 22963 | 58 | 29551500 |
Periorbital swelling | 22.53 | 14.24 | 9 | 22960 | 351 | 29551207 |
White blood cell count decreased | 22.50 | 14.24 | 19 | 22950 | 83343 | 29468215 |
Cyanosis | 22.28 | 14.24 | 35 | 22934 | 11232 | 29540326 |
Tachypnoea | 22.03 | 14.24 | 41 | 22928 | 15074 | 29536484 |
Neuropathy peripheral | 22.00 | 14.24 | 14 | 22955 | 71013 | 29480545 |
Blood pressure decreased | 21.60 | 14.24 | 81 | 22888 | 45396 | 29506162 |
Decreased appetite | 21.44 | 14.24 | 51 | 22918 | 145291 | 29406267 |
Neurological examination abnormal | 21.37 | 14.24 | 8 | 22961 | 261 | 29551297 |
Mixed dementia | 21.14 | 14.24 | 8 | 22961 | 269 | 29551289 |
Mumps | 20.99 | 14.24 | 6 | 22963 | 81 | 29551477 |
Diabetes mellitus | 20.95 | 14.24 | 3 | 22966 | 39828 | 29511730 |
Urinary bladder rupture | 20.79 | 14.24 | 6 | 22963 | 84 | 29551474 |
Partial seizures | 20.77 | 14.24 | 20 | 22949 | 3883 | 29547675 |
Hypoglycaemia | 20.57 | 14.24 | 6 | 22963 | 48340 | 29503218 |
Brain death | 20.44 | 14.24 | 16 | 22953 | 2354 | 29549204 |
Dyspnoea paroxysmal nocturnal | 20.40 | 14.24 | 13 | 22956 | 1381 | 29550177 |
Areflexia | 20.38 | 14.24 | 17 | 22952 | 2737 | 29548821 |
Procedural complication | 20.11 | 14.24 | 20 | 22949 | 4040 | 29547518 |
Medical device site fistula | 19.96 | 14.24 | 5 | 22964 | 39 | 29551519 |
Illusion | 19.64 | 14.24 | 10 | 22959 | 692 | 29550866 |
Product use in unapproved indication | 19.62 | 14.24 | 125 | 22844 | 86750 | 29464808 |
Neutropenia | 19.60 | 14.24 | 46 | 22923 | 131665 | 29419893 |
Hepatic cytolysis | 19.46 | 14.24 | 28 | 22941 | 8319 | 29543239 |
Drug withdrawal syndrome neonatal | 19.22 | 14.24 | 18 | 22951 | 3377 | 29548181 |
Hypernatraemia | 19.04 | 14.24 | 26 | 22943 | 7360 | 29544198 |
Hospitalisation | 19.03 | 14.24 | 6 | 22963 | 45982 | 29505576 |
Hyperaesthesia | 18.89 | 14.24 | 18 | 22951 | 3451 | 29548107 |
Encephalopathy | 18.84 | 14.24 | 60 | 22909 | 30983 | 29520575 |
Cardiac failure congestive | 18.83 | 14.24 | 19 | 22950 | 76562 | 29474996 |
Respiratory disorder | 18.71 | 14.24 | 41 | 22928 | 16942 | 29534616 |
Respiratory rate decreased | 18.69 | 14.24 | 14 | 22955 | 1931 | 29549627 |
COVID-19 | 18.66 | 14.24 | 66 | 22903 | 35948 | 29515610 |
Heart alternation | 18.48 | 14.24 | 3 | 22966 | 0 | 29551558 |
Weight decreased | 18.48 | 14.24 | 58 | 22911 | 150847 | 29400711 |
Postresuscitation encephalopathy | 18.43 | 14.24 | 4 | 22965 | 15 | 29551543 |
Electrocardiogram ST segment elevation | 18.42 | 14.24 | 20 | 22949 | 4472 | 29547086 |
Stupor | 18.39 | 14.24 | 16 | 22953 | 2728 | 29548830 |
Disease progression | 18.30 | 14.24 | 22 | 22947 | 81894 | 29469664 |
Angle closure glaucoma | 18.12 | 14.24 | 10 | 22959 | 815 | 29550743 |
Neurotoxicity | 18.09 | 14.24 | 37 | 22932 | 14576 | 29536982 |
Atonic urinary bladder | 17.84 | 14.24 | 4 | 22965 | 18 | 29551540 |
Parkinsonism | 17.83 | 14.24 | 25 | 22944 | 7253 | 29544305 |
Constipation | 17.69 | 14.24 | 39 | 22930 | 114121 | 29437437 |
Vomiting | 17.60 | 14.24 | 95 | 22874 | 212165 | 29339393 |
Arthrofibrosis | 17.32 | 14.24 | 5 | 22964 | 70 | 29551488 |
Ventricular fibrillation | 17.19 | 14.24 | 38 | 22931 | 15795 | 29535763 |
Anaemia | 17.18 | 14.24 | 89 | 22880 | 200862 | 29350696 |
Malaise | 17.07 | 14.24 | 65 | 22904 | 159537 | 29392021 |
Periventricular haemorrhage neonatal | 16.88 | 14.24 | 4 | 22965 | 24 | 29551534 |
Psychotic disorder | 16.87 | 14.24 | 44 | 22925 | 20310 | 29531248 |
Electrocardiogram QT prolonged | 16.85 | 14.24 | 64 | 22905 | 36073 | 29515485 |
Respiratory distress | 16.78 | 14.24 | 59 | 22910 | 32047 | 29519511 |
Administration related reaction | 16.59 | 14.24 | 5 | 22964 | 82 | 29551476 |
Haematuria traumatic | 16.41 | 14.24 | 6 | 22963 | 183 | 29551375 |
Encephalitis autoimmune | 16.24 | 14.24 | 8 | 22961 | 516 | 29551042 |
Klebsiella infection | 16.19 | 14.24 | 24 | 22945 | 7325 | 29544233 |
Muscle spasms | 16.17 | 14.24 | 16 | 22953 | 65066 | 29486492 |
Neuromuscular blockade | 16.05 | 14.24 | 6 | 22963 | 195 | 29551363 |
Haemoglobin decreased | 16.00 | 14.24 | 38 | 22931 | 108337 | 29443221 |
Product packaging confusion | 15.88 | 14.24 | 4 | 22965 | 32 | 29551526 |
Aggression | 15.80 | 14.24 | 62 | 22907 | 35479 | 29516079 |
Pain | 15.76 | 14.24 | 74 | 22895 | 171358 | 29380200 |
Weight increased | 15.67 | 14.24 | 22 | 22947 | 76645 | 29474913 |
Hyperexplexia | 15.67 | 14.24 | 4 | 22965 | 34 | 29551524 |
Catecholamine crisis | 15.56 | 14.24 | 4 | 22965 | 35 | 29551523 |
Pneumomediastinum | 15.46 | 14.24 | 12 | 22957 | 1744 | 29549814 |
Epilepsy | 15.43 | 14.24 | 40 | 22929 | 18392 | 29533166 |
Systemic inflammatory response syndrome | 15.33 | 14.24 | 21 | 22948 | 5960 | 29545598 |
Abdominal compartment syndrome | 15.28 | 14.24 | 9 | 22960 | 830 | 29550728 |
Abdominal pain upper | 15.14 | 14.24 | 15 | 22954 | 60978 | 29490580 |
Sinusitis | 15.10 | 14.24 | 4 | 22965 | 34346 | 29517212 |
Product contamination | 14.98 | 14.24 | 8 | 22961 | 611 | 29550947 |
Bronchitis | 14.92 | 14.24 | 5 | 22964 | 36863 | 29514695 |
Endotracheal intubation | 14.82 | 14.24 | 14 | 22955 | 2655 | 29548903 |
Cardio-respiratory arrest | 14.80 | 14.24 | 78 | 22891 | 50523 | 29501035 |
Asthma | 14.77 | 14.24 | 4 | 22965 | 33845 | 29517713 |
Hypoaesthesia | 14.65 | 14.24 | 12 | 22957 | 53455 | 29498103 |
Postoperative delirium | 14.50 | 14.24 | 4 | 22965 | 47 | 29551511 |
Hypertriglyceridaemia | 14.48 | 14.24 | 23 | 22946 | 7452 | 29544106 |
Chest pain | 14.44 | 14.24 | 42 | 22927 | 111931 | 29439627 |
Nervous system disorder | 14.42 | 14.24 | 31 | 22938 | 12643 | 29538915 |
Buttock injury | 14.27 | 14.24 | 4 | 22965 | 50 | 29551508 |
Somnolence | 14.25 | 14.24 | 123 | 22846 | 93832 | 29457726 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Status epilepticus | 441.55 | 13.74 | 237 | 42680 | 21426 | 64434389 |
Hypotension | 337.65 | 13.74 | 766 | 42151 | 380208 | 64075607 |
Cardiac arrest | 327.06 | 13.74 | 455 | 42462 | 153609 | 64302206 |
Anaphylactic reaction | 299.76 | 13.74 | 294 | 42623 | 68370 | 64387445 |
Serotonin syndrome | 283.81 | 13.74 | 224 | 42693 | 39058 | 64416757 |
Multiple-drug resistance | 266.69 | 13.74 | 115 | 42802 | 6387 | 64449428 |
Drug ineffective | 263.55 | 13.74 | 1178 | 41739 | 839069 | 63616746 |
Propofol infusion syndrome | 244.46 | 13.74 | 75 | 42842 | 1542 | 64454273 |
Fatigue | 183.28 | 13.74 | 139 | 42778 | 748591 | 63707224 |
Diabetes insipidus | 175.74 | 13.74 | 77 | 42840 | 4444 | 64451371 |
Metabolic acidosis | 175.47 | 13.74 | 226 | 42691 | 70732 | 64385083 |
Bradycardia | 172.82 | 13.74 | 294 | 42623 | 117925 | 64337890 |
Tachycardia | 166.91 | 13.74 | 331 | 42586 | 149248 | 64306567 |
Myoclonus | 161.81 | 13.74 | 134 | 42783 | 24984 | 64430831 |
Anaphylactic shock | 159.34 | 13.74 | 144 | 42773 | 30184 | 64425631 |
Drug reaction with eosinophilia and systemic symptoms | 157.05 | 13.74 | 187 | 42730 | 54030 | 64401785 |
Drug interaction | 155.30 | 13.74 | 561 | 42356 | 361522 | 64094293 |
Drug ineffective for unapproved indication | 152.23 | 13.74 | 142 | 42775 | 30991 | 64424824 |
Hyperthermia malignant | 150.62 | 13.74 | 58 | 42859 | 2401 | 64453414 |
Respiratory acidosis | 144.56 | 13.74 | 87 | 42830 | 9768 | 64446047 |
Multiple organ dysfunction syndrome | 137.47 | 13.74 | 244 | 42673 | 101169 | 64354646 |
Respiratory failure | 134.31 | 13.74 | 317 | 42600 | 160866 | 64294949 |
Delirium | 127.03 | 13.74 | 191 | 42726 | 69003 | 64386812 |
Generalised tonic-clonic seizure | 126.31 | 13.74 | 144 | 42773 | 39713 | 64416102 |
Joint swelling | 125.23 | 13.74 | 4 | 42913 | 215378 | 64240437 |
Agitation | 124.14 | 13.74 | 216 | 42701 | 88151 | 64367664 |
Arthralgia | 121.49 | 13.74 | 72 | 42845 | 442188 | 64013627 |
Diarrhoea | 121.15 | 13.74 | 184 | 42733 | 722520 | 63733295 |
Off label use | 120.97 | 13.74 | 776 | 42141 | 632030 | 63823785 |
Nausea | 117.91 | 13.74 | 215 | 42702 | 785585 | 63670230 |
Intensive care unit acquired weakness | 113.92 | 13.74 | 43 | 42874 | 1684 | 64454131 |
Anaesthetic complication | 113.64 | 13.74 | 48 | 42869 | 2531 | 64453284 |
Unresponsive to stimuli | 111.43 | 13.74 | 152 | 42765 | 50241 | 64405574 |
Seizure | 108.61 | 13.74 | 299 | 42618 | 166593 | 64289222 |
Circulatory collapse | 107.10 | 13.74 | 122 | 42795 | 33610 | 64422205 |
Fall | 106.07 | 13.74 | 74 | 42843 | 416752 | 64039063 |
Pain | 104.64 | 13.74 | 129 | 42788 | 553382 | 63902433 |
Headache | 101.55 | 13.74 | 122 | 42795 | 529345 | 63926470 |
Hypoxia | 100.55 | 13.74 | 197 | 42720 | 87952 | 64367863 |
Respiratory depression | 99.63 | 13.74 | 99 | 42818 | 23344 | 64432471 |
Necrosis ischaemic | 97.06 | 13.74 | 33 | 42884 | 950 | 64454865 |
Delayed recovery from anaesthesia | 97.02 | 13.74 | 37 | 42880 | 1491 | 64454324 |
Intestinal ischaemia | 96.83 | 13.74 | 72 | 42845 | 11477 | 64444338 |
Peripheral swelling | 95.54 | 13.74 | 13 | 42904 | 209140 | 64246675 |
Shock | 94.79 | 13.74 | 122 | 42795 | 38118 | 64417697 |
Acute respiratory distress syndrome | 94.61 | 13.74 | 123 | 42794 | 38812 | 64417003 |
Dizziness | 92.55 | 13.74 | 90 | 42827 | 430073 | 64025742 |
Pain in extremity | 92.51 | 13.74 | 43 | 42874 | 303042 | 64152773 |
Encephalopathy | 86.81 | 13.74 | 147 | 42770 | 58672 | 64397143 |
Pulseless electrical activity | 86.31 | 13.74 | 70 | 42847 | 12669 | 64443146 |
Apnoea | 85.20 | 13.74 | 64 | 42853 | 10358 | 64445457 |
Labile blood pressure | 82.71 | 13.74 | 36 | 42881 | 2044 | 64453771 |
Brain oedema | 82.51 | 13.74 | 87 | 42830 | 21988 | 64433827 |
Abdominal discomfort | 81.69 | 13.74 | 12 | 42905 | 182310 | 64273505 |
Anaesthetic complication neurological | 81.20 | 13.74 | 25 | 42892 | 520 | 64455295 |
Haemodynamic instability | 80.66 | 13.74 | 72 | 42845 | 14840 | 64440975 |
Alopecia | 78.82 | 13.74 | 9 | 42908 | 165681 | 64290134 |
Product dose omission issue | 78.20 | 13.74 | 17 | 42900 | 194730 | 64261085 |
Electroencephalogram abnormal | 76.48 | 13.74 | 46 | 42871 | 5157 | 64450658 |
Acidosis hyperchloraemic | 75.33 | 13.74 | 25 | 42892 | 667 | 64455148 |
Depressed level of consciousness | 75.30 | 13.74 | 167 | 42750 | 81269 | 64374546 |
Drug intolerance | 74.30 | 13.74 | 17 | 42900 | 187975 | 64267840 |
Partial seizures | 73.76 | 13.74 | 51 | 42866 | 7256 | 64448559 |
Nasopharyngitis | 73.10 | 13.74 | 20 | 42897 | 196053 | 64259762 |
Coma | 72.54 | 13.74 | 172 | 42745 | 87443 | 64368372 |
Intra-abdominal pressure increased | 71.42 | 13.74 | 19 | 42898 | 228 | 64455587 |
Myoglobin urine present | 71.02 | 13.74 | 23 | 42894 | 567 | 64455248 |
Mitochondrial DNA mutation | 70.53 | 13.74 | 19 | 42898 | 240 | 64455575 |
Rhabdomyolysis | 69.47 | 13.74 | 174 | 42743 | 91552 | 64364263 |
Systemic inflammatory response syndrome | 68.83 | 13.74 | 56 | 42861 | 10179 | 64445636 |
Cardiogenic shock | 65.98 | 13.74 | 94 | 42823 | 32333 | 64423482 |
Unwanted awareness during anaesthesia | 64.15 | 13.74 | 18 | 42899 | 267 | 64455548 |
Blood lactic acid increased | 63.89 | 13.74 | 54 | 42863 | 10347 | 64445468 |
Neuromuscular block prolonged | 63.27 | 13.74 | 24 | 42893 | 953 | 64454862 |
Septic shock | 62.76 | 13.74 | 183 | 42734 | 105254 | 64350561 |
Stress cardiomyopathy | 60.88 | 13.74 | 50 | 42867 | 9207 | 64446608 |
Asthenia | 60.55 | 13.74 | 121 | 42796 | 427923 | 64027892 |
Malaise | 60.45 | 13.74 | 107 | 42810 | 396140 | 64059675 |
Swelling | 58.49 | 13.74 | 17 | 42900 | 160201 | 64295614 |
Electrocardiogram ST segment elevation | 58.06 | 13.74 | 44 | 42873 | 7215 | 64448600 |
Toxicity to various agents | 57.97 | 13.74 | 427 | 42490 | 363086 | 64092729 |
Hyperthermia | 57.60 | 13.74 | 61 | 42856 | 15489 | 64440326 |
Myalgia | 57.59 | 13.74 | 17 | 42900 | 158600 | 64297215 |
Upper airway obstruction | 57.39 | 13.74 | 24 | 42893 | 1234 | 64454581 |
Laryngospasm | 57.31 | 13.74 | 33 | 42884 | 3412 | 64452403 |
Oxygen saturation decreased | 57.18 | 13.74 | 179 | 42738 | 106997 | 64348818 |
Oxygen saturation abnormal | 56.21 | 13.74 | 33 | 42884 | 3538 | 64452277 |
Weight increased | 55.34 | 13.74 | 37 | 42880 | 213311 | 64242504 |
Autonomic nervous system imbalance | 54.27 | 13.74 | 34 | 42883 | 4098 | 64451717 |
Renal ischaemia | 53.94 | 13.74 | 22 | 42895 | 1061 | 64454754 |
Hyperammonaemia | 53.92 | 13.74 | 48 | 42869 | 9856 | 64445959 |
Infusion related reaction | 53.86 | 13.74 | 21 | 42896 | 164446 | 64291369 |
Muscle rigidity | 53.44 | 13.74 | 62 | 42855 | 17411 | 64438404 |
Back pain | 52.96 | 13.74 | 53 | 42864 | 250118 | 64205697 |
Electrocardiogram QRS complex prolonged | 52.72 | 13.74 | 46 | 42871 | 9198 | 64446617 |
Pneumatosis | 52.68 | 13.74 | 20 | 42897 | 796 | 64455019 |
Ventricular tachycardia | 51.02 | 13.74 | 86 | 42831 | 34179 | 64421636 |
Product administered to patient of inappropriate age | 50.93 | 13.74 | 34 | 42883 | 4567 | 64451248 |
PCO2 increased | 50.90 | 13.74 | 24 | 42893 | 1643 | 64454172 |
Coagulopathy | 50.05 | 13.74 | 82 | 42835 | 31838 | 64423977 |
Hyperammonaemic encephalopathy | 49.83 | 13.74 | 32 | 42885 | 4026 | 64451789 |
Anaesthetic complication pulmonary | 49.16 | 13.74 | 11 | 42906 | 59 | 64455756 |
Pruritus | 48.85 | 13.74 | 83 | 42834 | 312317 | 64143498 |
Seizure like phenomena | 48.05 | 13.74 | 23 | 42894 | 1629 | 64454186 |
Foetal death | 47.55 | 13.74 | 36 | 42881 | 5894 | 64449921 |
Sinusitis | 47.18 | 13.74 | 19 | 42898 | 145909 | 64309906 |
Hypoventilation | 47.14 | 13.74 | 36 | 42881 | 5970 | 64449845 |
Mydriasis | 46.27 | 13.74 | 54 | 42863 | 15258 | 64440557 |
Catatonia | 45.65 | 13.74 | 39 | 42878 | 7581 | 64448234 |
Hepatic ischaemia | 44.96 | 13.74 | 19 | 42898 | 1003 | 64454812 |
COVID-19 pneumonia | 44.62 | 13.74 | 55 | 42862 | 16449 | 64439366 |
Toxic encephalopathy | 44.59 | 13.74 | 43 | 42874 | 9772 | 64446043 |
PO2 increased | 44.09 | 13.74 | 21 | 42896 | 1471 | 64454344 |
Dyspnoea | 44.08 | 13.74 | 289 | 42628 | 718385 | 63737430 |
Muscle relaxant therapy | 43.67 | 13.74 | 12 | 42905 | 164 | 64455651 |
Oropharyngeal oedema | 43.58 | 13.74 | 13 | 42904 | 242 | 64455573 |
Epileptic aura | 42.92 | 13.74 | 10 | 42907 | 66 | 64455749 |
Perforation | 42.83 | 13.74 | 19 | 42898 | 1129 | 64454686 |
Weight decreased | 42.78 | 13.74 | 78 | 42839 | 285661 | 64170154 |
Encephalitis autoimmune | 42.29 | 13.74 | 22 | 42895 | 1862 | 64453953 |
Ventricular extrasystoles | 41.98 | 13.74 | 55 | 42862 | 17474 | 64438341 |
Hypernatraemia | 41.96 | 13.74 | 46 | 42871 | 12143 | 64443672 |
Hypertransaminasaemia | 41.45 | 13.74 | 36 | 42881 | 7155 | 64448660 |
Tachypnoea | 41.31 | 13.74 | 68 | 42849 | 26503 | 64429312 |
Toxic epidermal necrolysis | 41.06 | 13.74 | 82 | 42835 | 37084 | 64418731 |
Abdominal pain upper | 40.68 | 13.74 | 34 | 42883 | 174996 | 64280819 |
Leukocytosis | 40.19 | 13.74 | 82 | 42835 | 37658 | 64418157 |
Systemic lupus erythematosus | 40.13 | 13.74 | 3 | 42914 | 77609 | 64378206 |
Anorectal ulcer | 39.95 | 13.74 | 9 | 42908 | 50 | 64455765 |
Non-consummation | 39.95 | 13.74 | 9 | 42908 | 50 | 64455765 |
Neurotoxicity | 39.77 | 13.74 | 68 | 42849 | 27336 | 64428479 |
Rash maculo-papular | 39.64 | 13.74 | 93 | 42824 | 46933 | 64408882 |
Troponin increased | 39.52 | 13.74 | 50 | 42867 | 15349 | 64440466 |
Epilepsy | 39.49 | 13.74 | 76 | 42841 | 33455 | 64422360 |
Procedural complication | 39.13 | 13.74 | 35 | 42882 | 7230 | 64448585 |
Ventricular hypokinesia | 39.05 | 13.74 | 36 | 42881 | 7733 | 64448082 |
Product use in unapproved indication | 38.79 | 13.74 | 225 | 42692 | 176393 | 64279422 |
Arthritis | 38.74 | 13.74 | 5 | 42912 | 83809 | 64372006 |
Long QT syndrome | 38.58 | 13.74 | 30 | 42887 | 5109 | 64450706 |
Bronchospasm | 38.55 | 13.74 | 59 | 42858 | 21623 | 64434192 |
Clonus | 38.29 | 13.74 | 32 | 42885 | 6035 | 64449780 |
Pseudopolyp | 37.73 | 13.74 | 13 | 42904 | 390 | 64455425 |
Anticholinergic syndrome | 37.69 | 13.74 | 23 | 42894 | 2646 | 64453169 |
Overdose | 37.49 | 13.74 | 207 | 42710 | 159359 | 64296456 |
Respiratory arrest | 37.49 | 13.74 | 98 | 42819 | 52887 | 64402928 |
Artery dissection | 37.17 | 13.74 | 11 | 42906 | 199 | 64455616 |
Bronchitis | 37.08 | 13.74 | 13 | 42904 | 108730 | 64347085 |
Altered state of consciousness | 36.46 | 13.74 | 79 | 42838 | 37823 | 64417992 |
Diabetic macroangiopathy | 36.37 | 13.74 | 10 | 42907 | 137 | 64455678 |
Hypoaesthesia | 36.22 | 13.74 | 24 | 42893 | 139084 | 64316731 |
Carcinoid crisis | 36.21 | 13.74 | 13 | 42904 | 441 | 64455374 |
Sinus bradycardia | 36.15 | 13.74 | 59 | 42858 | 22834 | 64432981 |
Electrocardiogram ST segment depression | 35.98 | 13.74 | 27 | 42890 | 4362 | 64451453 |
Herpes zoster | 35.94 | 13.74 | 5 | 42912 | 79182 | 64376633 |
Ultrasound ovary abnormal | 35.60 | 13.74 | 9 | 42908 | 87 | 64455728 |
Trigemino-cardiac reflex | 35.54 | 13.74 | 11 | 42906 | 233 | 64455582 |
Anticonvulsant drug level below therapeutic | 35.18 | 13.74 | 16 | 42901 | 1008 | 64454807 |
Blood creatine phosphokinase increased | 35.17 | 13.74 | 102 | 42815 | 58456 | 64397359 |
Asthma | 34.93 | 13.74 | 10 | 42907 | 95215 | 64360600 |
Dehydration | 34.40 | 13.74 | 57 | 42860 | 216706 | 64239109 |
Disseminated intravascular coagulation | 34.10 | 13.74 | 70 | 42847 | 32278 | 64423537 |
Blood pH decreased | 33.70 | 13.74 | 26 | 42891 | 4376 | 64451439 |
Urinary tract infection | 33.09 | 13.74 | 65 | 42852 | 231531 | 64224284 |
Tonic clonic movements | 32.95 | 13.74 | 19 | 42898 | 1970 | 64453845 |
Hepatic failure | 32.80 | 13.74 | 96 | 42821 | 55298 | 64400517 |
Kounis syndrome | 32.63 | 13.74 | 22 | 42895 | 3003 | 64452812 |
Discomfort | 32.56 | 13.74 | 7 | 42910 | 80871 | 64374944 |
Dyskinesia | 32.22 | 13.74 | 77 | 42840 | 39311 | 64416504 |
Aggression | 32.19 | 13.74 | 85 | 42832 | 46147 | 64409668 |
Decreased appetite | 32.12 | 13.74 | 89 | 42828 | 281200 | 64174615 |
Wound | 32.08 | 13.74 | 6 | 42911 | 76471 | 64379344 |
Paradoxical drug reaction | 32.01 | 13.74 | 29 | 42888 | 6091 | 64449724 |
Corneal reflex decreased | 31.67 | 13.74 | 11 | 42906 | 338 | 64455477 |
Intestinal infarction | 31.65 | 13.74 | 16 | 42901 | 1275 | 64454540 |
Psoriasis | 31.45 | 13.74 | 5 | 42912 | 71698 | 64384117 |
Procedural hypotension | 31.20 | 13.74 | 18 | 42899 | 1868 | 64453947 |
Neuroleptic malignant syndrome | 31.10 | 13.74 | 58 | 42859 | 24938 | 64430877 |
Neuromuscular blockade | 31.04 | 13.74 | 12 | 42905 | 502 | 64455313 |
Acute respiratory failure | 30.97 | 13.74 | 88 | 42829 | 49846 | 64405969 |
Musculoskeletal pain | 30.83 | 13.74 | 8 | 42909 | 81286 | 64374529 |
Unmasking of previously unidentified disease | 30.71 | 13.74 | 17 | 42900 | 1630 | 64454185 |
Injection site pain | 30.69 | 13.74 | 18 | 42899 | 111390 | 64344425 |
Cardiotoxicity | 30.65 | 13.74 | 36 | 42881 | 10238 | 64445577 |
White blood cell count decreased | 30.54 | 13.74 | 36 | 42881 | 157801 | 64298014 |
Ventricular fibrillation | 30.48 | 13.74 | 56 | 42861 | 23804 | 64432011 |
Cardio-respiratory arrest | 30.43 | 13.74 | 138 | 42779 | 98255 | 64357560 |
Palpitations | 30.05 | 13.74 | 16 | 42901 | 104472 | 64351343 |
Hypercapnia | 29.96 | 13.74 | 31 | 42886 | 7663 | 64448152 |
Airway complication of anaesthesia | 29.89 | 13.74 | 11 | 42906 | 401 | 64455414 |
Hyperaesthesia | 29.73 | 13.74 | 35 | 42882 | 9979 | 64445836 |
Acidosis | 29.65 | 13.74 | 47 | 42870 | 17748 | 64438067 |
Blood gases abnormal | 29.55 | 13.74 | 14 | 42903 | 969 | 64454846 |
Blood bicarbonate decreased | 29.51 | 13.74 | 25 | 42892 | 4804 | 64451011 |
Behaviour disorder | 29.13 | 13.74 | 24 | 42893 | 4438 | 64451377 |
Arthrofibrosis | 29.07 | 13.74 | 8 | 42909 | 110 | 64455705 |
Laryngeal stenosis | 28.97 | 13.74 | 13 | 42904 | 794 | 64455021 |
Fluid retention | 28.93 | 13.74 | 3 | 42914 | 59603 | 64396212 |
Acid base balance abnormal | 28.80 | 13.74 | 10 | 42907 | 307 | 64455508 |
Respiratory distress | 28.44 | 13.74 | 88 | 42829 | 52243 | 64403572 |
Airway peak pressure increased | 28.20 | 13.74 | 10 | 42907 | 327 | 64455488 |
Hypotonia | 28.13 | 13.74 | 36 | 42881 | 11176 | 64444639 |
Electrocardiogram QT prolonged | 28.07 | 13.74 | 116 | 42801 | 79332 | 64376483 |
Post procedural hypotension | 27.94 | 13.74 | 7 | 42910 | 65 | 64455750 |
Lower respiratory tract infection | 27.94 | 13.74 | 14 | 42903 | 94600 | 64361215 |
Procedural vomiting | 27.89 | 13.74 | 12 | 42905 | 662 | 64455153 |
Myocardial infarction | 27.82 | 13.74 | 42 | 42875 | 165779 | 64290036 |
Blood pressure decreased | 27.48 | 13.74 | 122 | 42795 | 86077 | 64369738 |
Gastrointestinal scarring | 27.37 | 13.74 | 9 | 42908 | 233 | 64455582 |
Hepatocellular injury | 27.36 | 13.74 | 79 | 42838 | 45156 | 64410659 |
Mucosal ulceration | 27.29 | 13.74 | 16 | 42901 | 1711 | 64454104 |
Therapeutic product effect prolonged | 27.26 | 13.74 | 11 | 42906 | 516 | 64455299 |
Cardiac failure congestive | 27.22 | 13.74 | 28 | 42889 | 130552 | 64325263 |
Gene mutation | 27.01 | 13.74 | 17 | 42900 | 2065 | 64453750 |
Acute hepatic failure | 26.93 | 13.74 | 56 | 42861 | 26056 | 64429759 |
Intracranial pressure increased | 26.92 | 13.74 | 28 | 42889 | 6961 | 64448854 |
Herpes simplex viraemia | 26.84 | 13.74 | 9 | 42908 | 248 | 64455567 |
Pneumomediastinum | 26.39 | 13.74 | 19 | 42898 | 2881 | 64452934 |
Oliguria | 26.39 | 13.74 | 40 | 42877 | 14536 | 64441279 |
Diabetes mellitus | 26.26 | 13.74 | 6 | 42911 | 66468 | 64389347 |
Hepatitis fulminant | 25.74 | 13.74 | 26 | 42891 | 6248 | 64449567 |
Pulmonary oedema | 25.57 | 13.74 | 112 | 42805 | 78562 | 64377253 |
Acute kidney injury | 25.47 | 13.74 | 430 | 42487 | 448810 | 64007005 |
Brain death | 25.36 | 13.74 | 23 | 42894 | 4838 | 64450977 |
Intensive care unit delirium | 25.20 | 13.74 | 6 | 42911 | 44 | 64455771 |
Dyspepsia | 25.07 | 13.74 | 11 | 42906 | 80301 | 64375514 |
Musculoskeletal stiffness | 25.03 | 13.74 | 27 | 42890 | 123179 | 64332636 |
Contraindicated product administered | 24.98 | 13.74 | 21 | 42896 | 107808 | 64348007 |
Atrioventricular dissociation | 24.77 | 13.74 | 9 | 42908 | 316 | 64455499 |
Large intestinal stenosis | 24.57 | 13.74 | 17 | 42900 | 2420 | 64453395 |
Feeling abnormal | 24.24 | 13.74 | 32 | 42885 | 133570 | 64322245 |
Blood pressure increased | 24.14 | 13.74 | 49 | 42868 | 172503 | 64283312 |
Loss of personal independence in daily activities | 24.12 | 13.74 | 9 | 42908 | 72445 | 64383370 |
Sedation complication | 24.04 | 13.74 | 32 | 42885 | 10322 | 64445493 |
Influenza like illness | 23.53 | 13.74 | 6 | 42911 | 61696 | 64394119 |
Malignant catatonia | 23.47 | 13.74 | 9 | 42908 | 368 | 64455447 |
Left ventricular dysfunction | 23.20 | 13.74 | 41 | 42876 | 16913 | 64438902 |
Gait disturbance | 23.15 | 13.74 | 50 | 42867 | 172105 | 64283710 |
Cough | 23.03 | 13.74 | 113 | 42804 | 302035 | 64153780 |
Paralysis | 22.68 | 13.74 | 33 | 42884 | 11562 | 64444253 |
Product contamination | 22.62 | 13.74 | 12 | 42905 | 1057 | 64454758 |
Macroglossia | 22.59 | 13.74 | 12 | 42905 | 1060 | 64454755 |
Arrhythmia | 22.53 | 13.74 | 82 | 42835 | 52862 | 64402953 |
Chest pain | 22.47 | 13.74 | 81 | 42836 | 235899 | 64219916 |
Stomatitis | 22.28 | 13.74 | 24 | 42893 | 109581 | 64346234 |
Migraine | 22.23 | 13.74 | 7 | 42910 | 62670 | 64393145 |
Manipulation | 22.11 | 13.74 | 6 | 42911 | 78 | 64455737 |
Rash | 22.07 | 13.74 | 197 | 42720 | 458352 | 63997463 |
Mixed dementia | 21.99 | 13.74 | 8 | 42909 | 282 | 64455533 |
Intensive care | 21.92 | 13.74 | 10 | 42907 | 635 | 64455180 |
Pituitary apoplexy | 21.71 | 13.74 | 7 | 42910 | 170 | 64455645 |
Paraesthesia | 21.68 | 13.74 | 35 | 42882 | 134487 | 64321328 |
Dermatitis exfoliative generalised | 21.54 | 13.74 | 23 | 42894 | 5893 | 64449922 |
Muscle spasms | 21.52 | 13.74 | 38 | 42879 | 140985 | 64314830 |
Malabsorption | 21.35 | 13.74 | 20 | 42897 | 4383 | 64451432 |
Amylase increased | 21.07 | 13.74 | 29 | 42888 | 9656 | 64446159 |
Injection site reaction | 21.05 | 13.74 | 3 | 42914 | 46661 | 64409154 |
Dry mouth | 20.98 | 13.74 | 7 | 42910 | 60411 | 64395404 |
Contusion | 20.98 | 13.74 | 27 | 42890 | 113938 | 64341877 |
Hospitalisation | 20.92 | 13.74 | 12 | 42905 | 75195 | 64380620 |
Large intestine anastomosis | 20.85 | 13.74 | 6 | 42911 | 98 | 64455717 |
Blood cholesterol increased | 20.85 | 13.74 | 4 | 42913 | 50062 | 64405753 |
Haemophagocytic lymphohistiocytosis | 20.84 | 13.74 | 40 | 42877 | 17569 | 64438246 |
Hot flush | 20.79 | 13.74 | 3 | 42914 | 46232 | 64409583 |
Restlessness | 20.79 | 13.74 | 66 | 42851 | 39719 | 64416096 |
Gastrooesophageal reflux disease | 20.77 | 13.74 | 15 | 42902 | 83128 | 64372687 |
Medical device site fistula | 20.73 | 13.74 | 5 | 42912 | 39 | 64455776 |
Haemoglobin decreased | 20.59 | 13.74 | 64 | 42853 | 194999 | 64260816 |
Cholestasis | 20.38 | 13.74 | 71 | 42846 | 44801 | 64411014 |
Hepatorenal syndrome | 20.08 | 13.74 | 18 | 42899 | 3728 | 64452087 |
Drug resistance | 19.98 | 13.74 | 60 | 42857 | 35042 | 64420773 |
Post procedural complication | 19.96 | 13.74 | 44 | 42873 | 21309 | 64434506 |
Nervous system disorder | 19.84 | 13.74 | 46 | 42871 | 23032 | 64432783 |
Pulse absent | 19.78 | 13.74 | 27 | 42890 | 8919 | 64446896 |
Nail dystrophy | 19.71 | 13.74 | 10 | 42907 | 803 | 64455012 |
Infection parasitic | 19.61 | 13.74 | 8 | 42909 | 386 | 64455429 |
Superinfection | 19.52 | 13.74 | 18 | 42899 | 3868 | 64451947 |
Nystagmus | 19.50 | 13.74 | 27 | 42890 | 9041 | 64446774 |
Drug withdrawal convulsions | 19.50 | 13.74 | 14 | 42903 | 2114 | 64453701 |
Completed suicide | 19.45 | 13.74 | 80 | 42837 | 224334 | 64231481 |
Stupor | 19.44 | 13.74 | 22 | 42895 | 6013 | 64449802 |
Liver function test | 19.43 | 13.74 | 6 | 42911 | 126 | 64455689 |
Abdominal compartment syndrome | 19.38 | 13.74 | 12 | 42905 | 1416 | 64454399 |
Gastrointestinal mucosa hyperaemia | 19.04 | 13.74 | 8 | 42909 | 416 | 64455399 |
Brain stem auditory evoked response abnormal | 18.95 | 13.74 | 3 | 42914 | 0 | 64455815 |
Euthyroid sick syndrome | 18.87 | 13.74 | 5 | 42912 | 59 | 64455756 |
Cyanosis | 18.87 | 13.74 | 44 | 42873 | 22111 | 64433704 |
Vomiting | 18.85 | 13.74 | 256 | 42661 | 550861 | 63904954 |
Oedema peripheral | 18.84 | 13.74 | 74 | 42843 | 210243 | 64245572 |
Eosinophilia | 18.84 | 13.74 | 62 | 42855 | 38014 | 64417801 |
Electrocardiogram repolarisation abnormality | 18.67 | 13.74 | 13 | 42904 | 1869 | 64453946 |
Symptom masked | 18.62 | 13.74 | 11 | 42906 | 1193 | 64454622 |
Constipation | 18.51 | 13.74 | 84 | 42833 | 229253 | 64226562 |
Drug chemical incompatibility | 18.36 | 13.74 | 5 | 42912 | 66 | 64455749 |
Renal impairment | 18.35 | 13.74 | 153 | 42764 | 134864 | 64320951 |
Coronary artery embolism | 18.19 | 13.74 | 7 | 42910 | 289 | 64455526 |
Dyspnoea paroxysmal nocturnal | 17.94 | 13.74 | 13 | 42904 | 1991 | 64453824 |
Influenza | 17.85 | 13.74 | 27 | 42890 | 106504 | 64349311 |
Stridor | 17.84 | 13.74 | 19 | 42898 | 4855 | 64450960 |
Impaired healing | 17.77 | 13.74 | 9 | 42908 | 60464 | 64395351 |
Somnolence | 17.57 | 13.74 | 210 | 42707 | 203435 | 64252380 |
Neurological examination abnormal | 17.53 | 13.74 | 8 | 42909 | 508 | 64455307 |
Neutropenia | 17.46 | 13.74 | 91 | 42826 | 239533 | 64216282 |
Cellulitis | 17.43 | 13.74 | 22 | 42895 | 93635 | 64362180 |
Incorrect route of product administration | 17.41 | 13.74 | 44 | 42873 | 23254 | 64432561 |
Injection site erythema | 17.39 | 13.74 | 13 | 42904 | 70787 | 64385028 |
Nasal congestion | 17.35 | 13.74 | 9 | 42908 | 59649 | 64396166 |
Cytokine release syndrome | 17.34 | 13.74 | 41 | 42876 | 20788 | 64435027 |
Skin ulcer | 17.31 | 13.74 | 4 | 42913 | 43970 | 64411845 |
Haematuria traumatic | 17.29 | 13.74 | 6 | 42911 | 184 | 64455631 |
Transaminases increased | 17.26 | 13.74 | 67 | 42850 | 44527 | 64411288 |
Delayed graft function | 17.10 | 13.74 | 15 | 42902 | 3021 | 64452794 |
Alanine aminotransferase increased | 17.04 | 13.74 | 154 | 42763 | 138877 | 64316938 |
Post procedural haemorrhage | 16.93 | 13.74 | 30 | 42887 | 12401 | 64443414 |
Paradoxical pain | 16.87 | 13.74 | 3 | 42914 | 3 | 64455812 |
Inappropriate schedule of product administration | 16.84 | 13.74 | 22 | 42895 | 92264 | 64363551 |
Psychotic disorder | 16.83 | 13.74 | 56 | 42861 | 34522 | 64421293 |
Burning sensation | 16.82 | 13.74 | 6 | 42911 | 49658 | 64406157 |
Polyuria | 16.56 | 13.74 | 30 | 42887 | 12613 | 64443202 |
Hepatitis | 16.45 | 13.74 | 67 | 42850 | 45515 | 64410300 |
No adverse event | 16.43 | 13.74 | 49 | 42868 | 28512 | 64427303 |
Systolic dysfunction | 16.41 | 13.74 | 15 | 42902 | 3187 | 64452628 |
Myoglobin blood increased | 16.33 | 13.74 | 14 | 42903 | 2733 | 64453082 |
End-tidal CO2 decreased | 16.28 | 13.74 | 4 | 42913 | 34 | 64455781 |
Chronic obstructive pulmonary disease | 16.25 | 13.74 | 14 | 42903 | 71034 | 64384781 |
Ischaemic hepatitis | 16.23 | 13.74 | 15 | 42902 | 3231 | 64452584 |
Catecholamine crisis | 16.18 | 13.74 | 4 | 42913 | 35 | 64455780 |
Post procedural stroke | 16.06 | 13.74 | 5 | 42912 | 108 | 64455707 |
Cataract | 16.03 | 13.74 | 7 | 42910 | 51255 | 64404560 |
Fear | 16.03 | 13.74 | 39 | 42878 | 20132 | 64435683 |
Vision blurred | 16.01 | 13.74 | 22 | 42895 | 90294 | 64365521 |
Hyperexplexia | 15.88 | 13.74 | 4 | 42913 | 38 | 64455777 |
Injection site swelling | 15.81 | 13.74 | 4 | 42913 | 41349 | 64414466 |
Injection site pruritus | 15.79 | 13.74 | 3 | 42914 | 37823 | 64417992 |
Posterior reversible encephalopathy syndrome | 15.78 | 13.74 | 42 | 42875 | 22904 | 64432911 |
Syncope | 15.74 | 13.74 | 53 | 42864 | 157582 | 64298233 |
Areflexia | 15.70 | 13.74 | 18 | 42899 | 4989 | 64450826 |
Vertigo | 15.60 | 13.74 | 10 | 42907 | 59001 | 64396814 |
Transient ischaemic attack | 15.55 | 13.74 | 5 | 42912 | 44177 | 64411638 |
Febrile infection-related epilepsy syndrome | 15.52 | 13.74 | 4 | 42913 | 42 | 64455773 |
Local anaesthetic systemic toxicity | 15.38 | 13.74 | 8 | 42909 | 677 | 64455138 |
Administration related reaction | 15.33 | 13.74 | 5 | 42912 | 126 | 64455689 |
Balance disorder | 15.32 | 13.74 | 20 | 42897 | 83906 | 64371909 |
Wrong product administered | 15.14 | 13.74 | 22 | 42895 | 7698 | 64448117 |
Cardiac output decreased | 15.13 | 13.74 | 11 | 42906 | 1693 | 64454122 |
Nephrocalcinosis | 15.11 | 13.74 | 10 | 42907 | 1324 | 64454491 |
Vulvovaginal candidiasis | 15.05 | 13.74 | 12 | 42905 | 2118 | 64453697 |
Endotracheal intubation complication | 15.04 | 13.74 | 8 | 42909 | 708 | 64455107 |
Buttock injury | 14.97 | 13.74 | 5 | 42912 | 136 | 64455679 |
Axillary pain | 14.97 | 13.74 | 11 | 42906 | 1721 | 64454094 |
Osteonecrosis of jaw | 14.94 | 13.74 | 4 | 42913 | 39821 | 64415994 |
Poor feeding infant | 14.90 | 13.74 | 5 | 42912 | 138 | 64455677 |
Maternal exposure during pregnancy | 14.85 | 13.74 | 112 | 42805 | 95772 | 64360043 |
Rash pruritic | 14.80 | 13.74 | 10 | 42907 | 57394 | 64398421 |
Amaurosis | 14.75 | 13.74 | 9 | 42908 | 1035 | 64454780 |
Angle closure glaucoma | 14.71 | 13.74 | 13 | 42904 | 2644 | 64453171 |
Female genital tract fistula | 14.70 | 13.74 | 13 | 42904 | 2645 | 64453170 |
Anaphylactoid shock | 14.66 | 13.74 | 8 | 42909 | 746 | 64455069 |
Renal failure | 14.65 | 13.74 | 185 | 42732 | 181503 | 64274312 |
Teratoma | 14.64 | 13.74 | 5 | 42912 | 146 | 64455669 |
Gastric ulcer perforation | 14.63 | 13.74 | 11 | 42906 | 1782 | 64454033 |
Sleep disorder | 14.61 | 13.74 | 11 | 42906 | 59698 | 64396117 |
Exposure during pregnancy | 14.54 | 13.74 | 95 | 42822 | 77580 | 64378235 |
Stevens-Johnson syndrome | 14.53 | 13.74 | 53 | 42864 | 34196 | 64421619 |
Ejection fraction decreased | 14.43 | 13.74 | 47 | 42870 | 28660 | 64427155 |
Mixed liver injury | 14.39 | 13.74 | 18 | 42899 | 5463 | 64450352 |
Left ventricular hypertrophy | 14.33 | 13.74 | 24 | 42893 | 9482 | 64446333 |
Abdominal pain | 14.23 | 13.74 | 136 | 42781 | 312239 | 64143576 |
Visual impairment | 14.21 | 13.74 | 17 | 42900 | 74060 | 64381755 |
Clonic convulsion | 14.18 | 13.74 | 9 | 42908 | 1110 | 64454705 |
Tracheal injury | 14.15 | 13.74 | 4 | 42913 | 61 | 64455754 |
Acanthosis nigricans | 14.14 | 13.74 | 5 | 42912 | 162 | 64455653 |
Mobility decreased | 14.14 | 13.74 | 22 | 42895 | 85818 | 64369997 |
Nephrogenic diabetes insipidus | 14.13 | 13.74 | 11 | 42906 | 1876 | 64453939 |
Thrombophlebitis | 13.94 | 13.74 | 18 | 42899 | 5636 | 64450179 |
Heart alternation | 13.93 | 13.74 | 3 | 42914 | 13 | 64455802 |
Postoperative delirium | 13.92 | 13.74 | 5 | 42912 | 170 | 64455645 |
Atrioventricular block | 13.86 | 13.74 | 27 | 42890 | 11988 | 64443827 |
Ammonia increased | 13.86 | 13.74 | 20 | 42897 | 6957 | 64448858 |
Sinus tachycardia | 13.82 | 13.74 | 50 | 42867 | 32138 | 64423677 |
Apnoeic attack | 13.78 | 13.74 | 7 | 42910 | 564 | 64455251 |
Hyperbilirubinaemia | 13.76 | 13.74 | 38 | 42879 | 21167 | 64434648 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 53.78 | 30.84 | 27 | 118 | 890 | 83643 |
Epilepsy | 31.19 | 30.84 | 10 | 135 | 90 | 84443 |
Source | Code | Description |
---|---|---|
ATC | N05CD08 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
MeSH PA | D000759 | Adjuvants, Anesthesia |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D018686 | Anesthetics, Intravenous |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35488 | central nervous system depressants |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:38869 | general anaesthetic |
CHEBI has role | CHEBI:51371 | muscle relaxants |
CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
CHEBI has role | CHEBI:91016 | GABAA receptor agonists |
FDA EPC | N0000175694 | Benzodiazepine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Feeling agitated | indication | 24199005 | |
Anxiety | indication | 48694002 | |
General anesthesia | indication | 50697003 | |
Sedation | indication | 72641008 | |
Status epilepticus | indication | 230456007 | DOID:1824 |
Conscious sedation | indication | 314271007 | |
Local anesthesia | indication | 386761002 | |
Sedation as Adjunct to Anesthesia | indication | ||
Induce Anterograde Amnesia | indication | ||
Sedation in Intubated Patients | indication | ||
Preoperative Anxiety | indication | ||
Insomnia | off-label use | 193462001 | |
Cocaine-Associated Acute Ischemic Heart Disease | off-label use | ||
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Shock | contraindication | 27942005 | |
End stage renal disease | contraindication | 46177005 | DOID:784 |
Chronic heart failure | contraindication | 48447003 | |
Pregnancy, function | contraindication | 289908002 | |
Coma | contraindication | 371632003 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Hemodynamic instability | contraindication | 422773005 | |
Peripheral Vasoconstriction | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.07 | Basic |
pKa2 | 2.36 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
5MG/SPRAY | NAYZILAM | UCB INC | N211321 | May 17, 2019 | RX | SPRAY | NASAL | 8217033 | Jan. 18, 2028 | ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E., SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 12 YEARS OF AGE AND OLDER |
5MG/SPRAY | NAYZILAM | UCB INC | N211321 | May 17, 2019 | RX | SPRAY | NASAL | 9289432 | Jan. 18, 2028 | ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E., SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 12 YEARS OF AGE AND OLDER |
5MG/SPRAY | NAYZILAM | UCB INC | N211321 | May 17, 2019 | RX | SPRAY | NASAL | 9687495 | Jan. 18, 2028 | ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E., SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 12 YEARS OF AGE AND OLDER |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
5MG/SPRAY | NAYZILAM | UCB INC | N211321 | May 17, 2019 | RX | SPRAY | NASAL | May 21, 2022 | NEW PRODUCT |
EQ 50MG BASE/10ML (EQ 5MG BASE/ML) | SEIZALAM | MMT | N209566 | Sept. 14, 2018 | RX | SOLUTION | INTRAMUSCULAR | Sept. 14, 2025 | TREATMENT OF STATUS EPILEPTICUS IN ADULTS |
5MG/SPRAY | NAYZILAM | UCB INC | N211321 | May 17, 2019 | RX | SPRAY | NASAL | May 17, 2026 | ACUTE TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E., SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENTS USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 12 YEARS OF AGE AND OLDER |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA A receptor alpha-5/beta-2/gamma-3 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.26 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-1/beta-2/gamma-3 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.75 | WOMBAT-PK | CHEMBL | |||
GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.44 | WOMBAT-PK | CHEMBL | |||
GABA A receptor alpha-3/beta-2/gamma-3 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.61 | WOMBAT-PK | CHEMBL | |||
GABA A receptor alpha-5/beta-3/gamma-3 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.26 | WOMBAT-PK | CHEMBL | |||
GABA A receptor alpha-5/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 9.13 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 8.75 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 9.13 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | Km | 4.35 | WOMBAT-PK | |||||
Cytochrome P450 3A4 | Enzyme | Km | 6 | WOMBAT-PK | |||||
Translocator protein | Membrane receptor | Ki | 8.70 | CHEMBL | |||||
Thyrotropin-releasing hormone receptor | GPCR | ANTAGONIST | Ki | 5.49 | IUPHAR | ||||
GABA-A receptor; anion channel | Ion channel | Ki | 8.70 | CHEMBL |
ID | Source |
---|---|
4019839 | VUID |
N0000147927 | NUI |
D00550 | KEGG_DRUG |
59467-96-8 | SECONDARY_CAS_RN |
4017813 | VANDF |
4019839 | VANDF |
C0026056 | UMLSCUI |
CHEBI:6931 | CHEBI |
08J | PDB_CHEM_ID |
CHEMBL655 | ChEMBL_ID |
CHEMBL1200420 | ChEMBL_ID |
DB00683 | DRUGBANK_ID |
D008874 | MESH_DESCRIPTOR_UI |
4192 | PUBCHEM_CID |
3342 | IUPHAR_LIGAND_ID |
4497 | INN_ID |
R60L0SM5BC | UNII |
203128 | RXNORM |
130935 | MMSL |
24970 | MMSL |
32073 | MMSL |
5114 | MMSL |
d00301 | MMSL |
001467 | NDDF |
004585 | NDDF |
26800000 | SNOMEDCT_US |
373476007 | SNOMEDCT_US |
84213009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3566 | SYRUP | 2 mg | ORAL | ANDA | 25 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9912 | INJECTION, SOLUTION | 1 mg | INTRAVENOUS | ANDA | 14 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9913 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 15 sections |
MIDAZOLAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9914 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 14 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9915 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 14 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9916 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 15 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2305 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | ANDA | 29 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2305 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | ANDA | 29 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2308 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 29 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2308 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 29 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2587 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | ANDA | 28 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2596 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | ANDA | 28 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0150 | SYRUP | 2 mg | ORAL | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6056 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6057 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6059 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6060 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6061 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6063 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6190 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6190 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6209 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6210 | INJECTION | 1 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6211 | INJECTION | 5 mg | INTRAMUSCULAR | ANDA | 27 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7113 | SYRUP | 2 mg | ORAL | ANDA | 25 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7114 | SYRUP | 2 mg | ORAL | ANDA | 25 sections |
Seizalam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11704-650 | INJECTION, SOLUTION | 5 mg | INTRAMUSCULAR | NDA | 32 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-523 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 28 sections |
Midazolam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-524 | INJECTION | 5 mg | INTRAVENOUS | ANDA | 28 sections |
Midazolam Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0146 | SYRUP | 2 mg | ORAL | ANDA | 27 sections |