All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sulfamethoxazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2514	723-46-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: sulfamethoxazole sulfamethalazole sulfamethoxazol sulfisomezole sulphamethoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) Molecular weight: 253.28 Formula: C10H11N3O3S CLOGP: 0.56 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 98.22 ALOGS: -2.74 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.50 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	14 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	394.82 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.23 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	9.80 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
July 30, 1973	FDA	MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sleep disorder due to general medical condition, insomnia type	1387.22	12.91	866	84122	51351	63352683
Folliculitis	1374.95	12.91	963	84025	69354	63334680
Muscle injury	1364.81	12.91	932	84056	64413	63339621
Irritable bowel syndrome	1218.58	12.91	954	84034	81458	63322576
Impaired healing	1028.99	12.91	950	84038	101592	63302442
Gastrointestinal disorder	941.61	12.91	1013	83975	130226	63273808
Blister	903.28	12.91	986	84002	128828	63275206
Stomatitis	861.41	12.91	993	83995	137732	63266302
Lower respiratory tract infection	839.90	12.91	958	84030	131349	63272685
Duodenal ulcer perforation	740.04	12.91	737	84251	86472	63317562
Ill-defined disorder	719.83	12.91	705	84283	81050	63322984
Helicobacter infection	687.51	12.91	729	84259	92056	63311978
Infection	576.97	12.91	1070	83918	228103	63175931
Therapeutic product effect decreased	547.54	12.91	950	84038	192237	63211797
Confusional state	542.39	12.91	1061	83927	235319	63168715
Sinusitis	501.37	12.91	1002	83986	225651	63178383
Pericarditis	487.29	12.91	731	84257	130848	63273186
Anti-cyclic citrullinated peptide antibody positive	486.15	12.91	684	84304	115528	63288506
Contusion	423.66	12.91	737	84251	149307	63254727
Weight increased	407.19	12.91	1003	83985	259789	63144245
Nasopharyngitis	401.32	12.91	982	84006	253275	63150759
Pyrexia	392.14	12.91	1449	83539	469029	62935005
Peripheral swelling	387.13	12.91	996	83992	264946	63139088
Hand deformity	376.50	12.91	725	84263	158732	63245302
Discomfort	374.57	12.91	744	84244	166630	63237404
Synovitis	370.22	12.91	790	84198	186128	63217906
Hypersensitivity	366.62	12.91	1037	83951	291648	63112386
Swelling	357.96	12.91	989	83999	274389	63129645
Hepatic enzyme increased	304.76	12.91	768	84220	201560	63202474
Arthropathy	304.68	12.91	843	84145	233949	63170085
Pemphigus	302.83	12.91	722	84266	183004	63221030
Glossodynia	300.29	12.91	708	84280	178168	63225866
Wound	293.61	12.91	664	84324	162599	63241435
Pruritus	280.46	12.91	1089	83899	360364	63043670
Joint swelling	278.88	12.91	1017	83971	326649	63077385
Systemic lupus erythematosus	259.03	12.91	738	84250	208180	63195854
Infusion related reaction	247.94	12.91	807	84181	244714	63159320
Fall	245.82	12.91	109	84879	392225	63011809
Product dose omission issue	216.09	12.91	29	84959	234284	63169750
Death	203.42	12.91	125	84863	374256	63029778
Toxicity to various agents	167.24	12.91	61	84927	247189	63156845
Abdominal discomfort	164.87	12.91	856	84132	320029	63084005
Contraindicated product administered	163.70	12.91	650	84338	216998	63187036
Drug intolerance	161.07	12.91	827	84161	307834	63096200
Nausea	150.76	12.91	612	84376	853859	62550175
Completed suicide	146.99	12.91	13	84975	145660	63258374
Rheumatoid arthritis	140.02	12.91	691	84297	253128	63150906
Rash	138.45	12.91	1248	83740	559623	62844411
Pain in extremity	133.75	12.91	148	84840	331338	63072696
Headache	128.23	12.91	428	84560	632813	62771221
Medication error	125.91	12.91	240	84748	52044	63351990
Cough	123.32	12.91	126	84862	292617	63111417
Injection site pain	122.16	12.91	15	84973	129785	63274249
Off label use	120.03	12.91	481	84507	673981	62730053
Dizziness	118.53	12.91	249	84739	429676	62974358
Deep vein thrombosis postoperative	111.14	12.91	104	84884	11265	63392769
Blood pressure increased	106.16	12.91	42	84946	162020	63242014
Malaise	103.20	12.91	255	84733	415699	62988335
Diarrhoea	101.94	12.91	553	84435	714813	62689221
Alopecia	99.44	12.91	782	84206	336754	63067280
Autoimmune disorder	93.16	12.91	115	84873	17062	63386972
COVID-19	91.02	12.91	20	84968	113083	63290951
Feeling abnormal	89.98	12.91	43	84945	148349	63255685
Pre-engraftment immune reaction	88.77	12.91	26	84962	212	63403822
Pneumonia	87.37	12.91	316	84672	456451	62947583
Intentional overdose	85.82	12.91	3	84985	74149	63329885
Constipation	77.57	12.91	113	84875	224830	63179204
Maternal exposure timing unspecified	75.44	12.91	68	84920	7019	63397015
Back pain	75.21	12.91	150	84838	263995	63140039
Psoriasis	74.97	12.91	13	84975	86944	63317090
Pregnancy	71.90	12.91	155	84833	36681	63367353
Drug abuse	71.72	12.91	7	84981	72511	63331523
Injection site erythema	70.48	12.91	13	84975	83161	63320873
Arthralgia	70.36	12.91	1111	83877	568599	62835435
Inappropriate schedule of product administration	69.63	12.91	26	84962	103939	63300095
Alanine aminotransferase abnormal	63.94	12.91	51	84937	4453	63399581
Injection site reaction	62.48	12.91	4	84984	58520	63345514
Injury	61.71	12.91	227	84761	73020	63331014
Therapy non-responder	60.43	12.91	231	84757	75670	63328364
Balance disorder	60.18	12.91	19	84969	84403	63319631
Urinary tract infection	59.67	12.91	170	84818	264514	63139520
Maternal exposure during pregnancy	59.36	12.91	500	84488	219562	63184472
Influenza	59.32	12.91	36	84952	108686	63295348
Hyperhidrosis	58.43	12.91	36	84952	107800	63296234
Myocardial infarction	57.47	12.91	31	84957	99862	63304172
Suicide attempt	57.39	12.91	7	84981	60911	63343123
Encephalitis viral	56.96	12.91	33	84955	1699	63402335
Wrong technique in product usage process	56.73	12.91	8	84980	62332	63341702
Oropharyngeal pain	56.32	12.91	28	84960	94459	63309575
C-reactive protein	56.26	12.91	49	84939	4833	63399201
Syncope	55.94	12.91	45	84943	117340	63286694
Dyspnoea	55.92	12.91	1216	83772	660097	62743937
Adjustment disorder with depressed mood	53.22	12.91	67	84921	10137	63393897
Deafness transitory	53.03	12.91	33	84955	1937	63402097
Red blood cell sedimentation rate	52.51	12.91	47	84941	4807	63399227
Cerebrovascular accident	51.99	12.91	41	84947	107983	63296051
Loss of consciousness	50.62	12.91	50	84938	118071	63285963
Lip dry	50.21	12.91	81	84907	15389	63388645
Stress	48.08	12.91	15	84973	67152	63336882
Hypotension	47.89	12.91	195	84793	272409	63131625
Illness	47.82	12.91	5	84983	49054	63354980
Human herpesvirus 6 infection	47.44	12.91	36	84952	2921	63401113
Vomiting	45.73	12.91	504	84484	559113	62844921
Suicidal ideation	44.58	12.91	14	84974	62407	63341627
Injection site bruising	44.33	12.91	3	84985	41907	63362127
Fear of injection	43.83	12.91	51	84937	7113	63396921
Atrial fibrillation	43.81	12.91	55	84933	116581	63287453
Injection site swelling	43.53	12.91	6	84982	47566	63356468
Fluid retention	43.32	12.91	13	84975	59673	63344361
Chest discomfort	43.27	12.91	50	84938	109919	63294115
Nasal congestion	42.99	12.91	17	84971	65643	63338391
Myalgia	42.71	12.91	82	84906	146447	63257587
Cataract	42.19	12.91	12	84976	57041	63346993
Flushing	42.17	12.91	24	84964	75063	63328971
Palpitations	41.50	12.91	54	84934	112716	63291318
Tongue disorder	40.80	12.91	60	84928	10520	63393514
Muscle spasms	40.79	12.91	93	84895	156057	63247977
Visual impairment	40.70	12.91	32	84956	84414	63319620
Neck pain	40.62	12.91	21	84967	69297	63334737
Breast cancer	40.06	12.91	8	84980	48375	63355659
Rhinorrhoea	39.73	12.91	19	84969	65558	63338476
Condition aggravated	39.19	12.91	347	84641	401870	63002164
Bronchitis	39.01	12.91	67	84921	124868	63279166
Injection site pruritus	38.33	12.91	7	84981	45109	63358925
Weight decreased	38.11	12.91	216	84772	276582	63127452
C-reactive protein abnormal	38.09	12.91	142	84846	45954	63358080
Enthesopathy	37.86	12.91	52	84936	8562	63395472
Blood pressure fluctuation	37.64	12.91	8	84980	46309	63357725
Hot flush	37.39	12.91	11	84977	51148	63352886
Dysphonia	37.14	12.91	9	84979	47605	63356429
Incorrect dose administered	36.91	12.91	17	84971	59951	63344083
Drug interaction	36.51	12.91	170	84818	228961	63175073
Therapeutic product effect incomplete	36.43	12.91	70	84918	124986	63279048
Multiple sclerosis relapse	36.21	12.91	10	84978	48468	63355566
Cardiac failure congestive	35.32	12.91	43	84945	92390	63311644
Sleep disorder	35.30	12.91	208	84780	81358	63322676
Cardiac disorder	35.22	12.91	12	84976	50804	63353230
Oxygen saturation decreased	35.15	12.91	40	84948	88545	63315489
Haematochezia	34.83	12.91	14	84974	53530	63350504
Heart rate increased	34.80	12.91	45	84943	94193	63309841
Depressed mood	34.65	12.91	6	84982	40185	63363849
Abdominal distension	34.49	12.91	39	84949	86576	63317458
Asthenia	34.33	12.91	338	84650	383266	63020768
Osteoporosis	34.15	12.91	17	84971	57321	63346713
Unevaluable event	34.15	12.91	13	84975	51373	63352661
Tenosynovitis	34.03	12.91	64	84924	13731	63390303
Influenza like illness	33.90	12.91	24	84964	66800	63337234
Overdose	33.88	12.91	64	84924	115014	63289020
Throat irritation	33.86	12.91	5	84983	37642	63366392
Gait disturbance	33.43	12.91	129	84859	183049	63220985
Disease progression	32.96	12.91	72	84916	122686	63281348
Depression	32.36	12.91	144	84844	196348	63207686
Femur fracture	32.36	12.91	8	84980	41748	63362286
No adverse event	31.95	12.91	8	84980	41397	63362637
Cytomegalovirus infection	31.92	12.91	80	84908	20872	63383162
Full blood count abnormal	31.52	12.91	3	84985	31714	63372320
Blood parathyroid hormone decreased	31.41	12.91	51	84937	9740	63394294
Bradycardia	31.36	12.91	31	84957	73196	63330838
Lower limb fracture	31.31	12.91	87	84901	24134	63379900
X-ray abnormal	31.28	12.91	46	84942	8064	63395970
Adverse event	31.00	12.91	175	84813	67384	63336650
Dry skin	30.79	12.91	19	84969	56868	63347166
Kidney transplant rejection	30.57	12.91	33	84955	4238	63399796
Hypertension	29.87	12.91	235	84753	279068	63124966
Cognitive disorder	29.72	12.91	19	84969	55796	63348238
Dislocation of vertebra	29.10	12.91	46	84942	8589	63395445
Sedation	29.00	12.91	8	84980	38801	63365233
Functional gastrointestinal disorder	28.91	12.91	32	84956	4227	63399807
Herpes zoster	28.81	12.91	41	84947	82421	63321613
Granuloma	28.74	12.91	37	84951	5724	63398310
Cardio-respiratory arrest	28.54	12.91	23	84965	59936	63344098
Device expulsion	28.44	12.91	6	84982	34916	63369118
Vision blurred	28.05	12.91	50	84938	91874	63312160
Road traffic accident	27.93	12.91	110	84878	36522	63367512
Hypokalaemia	27.77	12.91	61	84927	103743	63300291
Dysgeusia	27.59	12.91	14	84974	46696	63357338
Chronic obstructive pulmonary disease	27.47	12.91	26	84962	62660	63341374
Abdominal pain	27.32	12.91	256	84732	293200	63110834
Pain in jaw	27.29	12.91	12	84976	43484	63360550
Nephrolithiasis	27.27	12.91	11	84977	41973	63362061
Panniculitis	27.07	12.91	52	84936	11333	63392701
Foetal exposure during pregnancy	27.06	12.91	5	84983	31957	63372077
Blood glucose increased	26.99	12.91	44	84944	83712	63320322
Limb discomfort	26.60	12.91	4	84984	29712	63374322
Skin necrosis	26.42	12.91	58	84930	13892	63390142
Hypothyroidism	26.37	12.91	12	84976	42620	63361414
Intentional product misuse	25.84	12.91	26	84962	60891	63343143
Surgery	25.74	12.91	8	84980	35904	63368130
Drug ineffective for unapproved indication	25.49	12.91	7	84981	34056	63369978
Vertigo	24.91	12.91	26	84962	59861	63344173
Neuropathy peripheral	24.85	12.91	74	84914	113593	63290441
Product prescribing error	24.81	12.91	3	84985	26286	63377748
Anxiety	24.69	12.91	180	84808	217361	63186673
Paraesthesia	24.67	12.91	117	84871	156849	63247185
Meningoencephalitis herpetic	24.41	12.91	17	84971	1207	63402827
Abnormal loss of weight	24.06	12.91	34	84954	5748	63398286
Intestinal obstruction	23.79	12.91	6	84982	30893	63373141
Erythema	23.70	12.91	138	84850	175613	63228421
Epistaxis	23.62	12.91	38	84950	72687	63331347
Facet joint syndrome	23.59	12.91	51	84937	12087	63391947
Hospitalisation	23.59	12.91	49	84939	85032	63319002
Tremor	23.56	12.91	94	84894	132145	63271889
Rheumatoid nodule	23.55	12.91	63	84925	17092	63386942
Breast cancer stage II	23.40	12.91	42	84946	8694	63395340
Arrhythmia	23.18	12.91	11	84977	38129	63365905
Tachycardia	23.00	12.91	81	84907	118075	63285959
Anaphylactic reaction	22.95	12.91	33	84955	66067	63337967
Drug dependence	22.61	12.91	3	84985	24480	63379554
Malignant neoplasm progression	22.18	12.91	48	84940	82073	63321961
Dysphagia	22.13	12.91	54	84934	88531	63315503
Anaphylactic shock	21.57	12.91	3	84985	23630	63380404
Serotonin syndrome	21.26	12.91	6	84982	28676	63375358
Swollen tongue	21.21	12.91	10	84978	34790	63369244
Renal impairment	21.19	12.91	55	84933	88300	63315734
Wound infection	21.18	12.91	70	84918	21340	63382694
Complications of transplanted kidney	21.02	12.91	21	84967	2465	63401569
Oral pain	20.94	12.91	6	84982	28388	63375646
Product quality issue	20.81	12.91	11	84977	35854	63368180
Blood calcium decreased	20.63	12.91	5	84983	26446	63377588
Tinnitus	20.57	12.91	11	84977	35617	63368417
Sinus disorder	20.45	12.91	4	84984	24549	63379485
Osteonecrosis of jaw	20.05	12.91	11	84977	35112	63368922
Musculoskeletal disorder	19.98	12.91	67	84921	20577	63383457
Gastrointestinal haemorrhage	19.87	12.91	50	84938	81126	63322908
Heart rate decreased	19.84	12.91	19	84969	45541	63358493
Depressed level of consciousness	19.64	12.91	33	84955	62045	63341989
Flatulence	19.61	12.91	11	84977	34691	63369343
Anaemia	19.48	12.91	276	84712	293154	63110880
Angina pectoris	19.34	12.91	8	84980	30070	63373964
HIV infection	19.28	12.91	10	84978	413	63403621
Disturbance in attention	19.00	12.91	14	84974	38175	63365859
Cardiac arrest	18.99	12.91	62	84926	92483	63311551
Dry eye	18.94	12.91	16	84972	40745	63363289
Tooth disorder	18.91	12.91	7	84981	28150	63375884
Cardiac failure	18.79	12.91	59	84929	89083	63314951
Somnolence	18.78	12.91	151	84837	178534	63225500
Seasonal allergy	18.34	12.91	3	84985	20947	63383087
Dyspnoea exertional	18.22	12.91	33	84955	60269	63343765
Granuloma skin	18.20	12.91	37	84951	8400	63395634
Chills	18.11	12.91	84	84904	113294	63290740
Febrile bone marrow aplasia	18.09	12.91	34	84954	7291	63396743
Burning sensation	18.08	12.91	28	84960	54379	63349655
Migraine	18.07	12.91	74	84914	103272	63300762
Drug hypersensitivity	18.07	12.91	544	84444	310143	63093891
Hypoglycaemia	18.03	12.91	33	84955	60032	63344002
Urticaria	18.00	12.91	317	84671	165485	63238549
Device dislocation	17.94	12.91	6	84982	25699	63378335
Localised infection	17.92	12.91	9	84979	30201	63373833
Productive cough	17.86	12.91	36	84952	63172	63340862
Diabetic ketoacidosis	17.81	12.91	3	84985	20502	63383532
Liver disorder	17.77	12.91	128	84860	53559	63350475
Acquired immunodeficiency syndrome	17.64	12.91	6	84982	83	63403951
Cystitis	17.61	12.91	29	84959	54962	63349072
Electrocardiogram QT prolonged	17.61	12.91	33	84955	59497	63344537
Immunodeficiency	17.51	12.91	3	84985	20251	63383783
Intervertebral disc protrusion	17.50	12.91	5	84983	23704	63380330
Anti-cyclic citrullinated peptide antibody	17.48	12.91	32	84956	6726	63397308
Drug ineffective	17.31	12.91	1186	83802	1043579	62360455
Withdrawal syndrome	17.21	12.91	3	84985	19994	63384040
Hip fracture	17.16	12.91	9	84979	29465	63374569
Haemorrhage	17.04	12.91	35	84953	60987	63343047
Sleep apnoea syndrome	16.81	12.91	9	84979	29124	63374910
Blood pressure decreased	16.74	12.91	39	84949	64983	63339051
Rheumatoid lung	16.57	12.91	23	84965	3825	63400209
Mouth ulceration	16.53	12.91	12	84976	32972	63371062
Drug withdrawal syndrome	16.29	12.91	8	84980	27186	63376848
Grip strength decreased	16.25	12.91	66	84922	22221	63381813
Rheumatic fever	16.17	12.91	106	84882	43005	63361029
Product administration error	16.03	12.91	5	84983	22392	63381642
Obstructive airways disorder	15.97	12.91	4	84984	20695	63383339
Tendonitis	15.85	12.91	60	84928	19555	63384479
Orthostatic hypotension	15.84	12.91	15	84973	36145	63367889
Metastases to liver	15.67	12.91	6	84982	23633	63380401
Peripheral venous disease	15.67	12.91	51	84937	15426	63388608
Bone pain	15.54	12.91	31	84957	54610	63349424
Diverticulitis	15.54	12.91	18	84970	39539	63364495
Joint stiffness	15.45	12.91	20	84968	41849	63362185
Swollen joint count increased	14.99	12.91	91	84897	35963	63368071
Chemotherapeutic drug level increased	14.94	12.91	6	84982	135	63403899
Hallucination	14.83	12.91	32	84956	54785	63349249
Upper respiratory tract infection	14.81	12.91	58	84930	81989	63322045
Ischaemic stroke	14.80	12.91	3	84985	17954	63386080
Pulmonary arterial hypertension	14.53	12.91	6	84982	22571	63381463
Limb injury	14.51	12.91	8	84980	25469	63378565
Metastases to bone	14.50	12.91	5	84983	21014	63383020
Stevens-Johnson syndrome	14.47	12.91	69	84919	24881	63379153
Speech disorder	14.39	12.91	20	84968	40609	63363425
Exposure during pregnancy	14.32	12.91	136	84852	155411	63248623
Pneumonia aspiration	14.24	12.91	87	84901	34453	63369581
Joint range of motion decreased	14.22	12.91	83	84905	32345	63371689
Foot deformity	14.13	12.91	10	84978	27843	63376191
Aphasia	14.09	12.91	14	84974	32986	63371048
Haematemesis	14.06	12.91	12	84976	30400	63373634
Melaena	14.01	12.91	12	84976	30353	63373681
Upper limb fracture	14.00	12.91	4	84984	18964	63385070
Seizure	13.97	12.91	112	84876	132522	63271512
Swollen joint count	13.86	12.91	12	84976	1174	63402860
Angioedema	13.83	12.91	27	84961	47938	63356096
Therapeutic response unexpected	13.77	12.91	4	84984	18755	63385279
Trimethylaminuria	13.76	12.91	6	84982	167	63403867
Drug eruption	13.61	12.91	75	84913	28619	63375415
Infusion site pain	13.53	12.91	3	84985	16866	63387168
Eczema	13.45	12.91	14	84974	32277	63371757
Pulmonary hypertension	13.42	12.91	18	84970	37105	63366929
Nervousness	13.39	12.91	13	84975	30966	63373068
Psychotic disorder	13.35	12.91	9	84979	25703	63378331
Acute myocardial infarction	13.30	12.91	14	84974	32110	63371924
Dysarthria	13.24	12.91	23	84965	42688	63361346
Bacterial sepsis	13.22	12.91	21	84967	3937	63400097
Respiratory tract infection	13.17	12.91	22	84966	41461	63362573
Feeling hot	13.13	12.91	30	84958	50324	63353710
Blood pressure diastolic decreased	13.12	12.91	7	84981	22699	63381335
Eye disorder	13.10	12.91	7	84981	22678	63381356
Gait inability	13.03	12.91	118	84870	52841	63351193
Renal tubular disorder	13.03	12.91	17	84971	2665	63401369
Hypersomnia	12.98	12.91	4	84984	18051	63385983
Cytomegalovirus test positive	12.94	12.91	18	84970	3000	63401034
Fracture	12.93	12.91	5	84983	19579	63384455
Hypocalcaemia	12.93	12.91	14	84974	31699	63372335

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pyrexia	153.89	11.55	724	36044	332289	34587874
Drug ineffective	136.18	11.55	169	36599	456582	34463581
Cytomegalovirus infection	107.50	11.55	135	36633	26000	34894163
Off label use	96.35	11.55	185	36583	419339	34500824
Lymphocyte count decreased	91.67	11.55	116	36652	22506	34897657
Immune reconstitution inflammatory syndrome	91.54	11.55	75	36693	8684	34911479
Neutropenia	91.26	11.55	366	36402	156412	34763751
Death	90.96	11.55	176	36592	397873	34522290
Hyperkalaemia	88.39	11.55	213	36555	69176	34850987
Aspartate aminotransferase increased	87.34	11.55	209	36559	67574	34852589
Blood creatinine increased	86.08	11.55	257	36511	94719	34825444
Alanine aminotransferase increased	84.23	11.55	230	36538	80585	34839578
Clear cell renal cell carcinoma	84.09	11.55	35	36733	1112	34919051
Pancytopenia	81.10	11.55	252	36516	94905	34825258
Lymphoproliferative disorder	75.84	11.55	43	36725	2716	34917447
Stevens-Johnson syndrome	74.60	11.55	95	36673	18544	34901619
Transplant rejection	73.30	11.55	71	36697	10240	34909923
Product dose omission issue	62.27	11.55	24	36744	119687	34800476
Kidney transplant rejection	59.74	11.55	55	36713	7442	34912721
Acute kidney injury	54.99	11.55	525	36243	304463	34615700
Tenosynovitis	53.87	11.55	42	36726	4528	34915635
Granuloma skin	52.35	11.55	26	36742	1253	34918910
Tongue disorder	52.22	11.55	44	36724	5295	34914868
Blood urea increased	51.98	11.55	105	36663	30259	34889904
Enthesopathy	51.37	11.55	41	36727	4572	34915591
Red blood cell sedimentation rate	51.16	11.55	25	36743	1163	34919000
Hepatic cytolysis	50.46	11.55	69	36699	14427	34905736
Alanine aminotransferase abnormal	48.68	11.55	40	36728	4648	34915515
Pneumocystis jirovecii pneumonia	47.46	11.55	79	36689	19631	34900532
Panniculitis	46.67	11.55	28	36740	1966	34918197
Renal tubular necrosis	46.28	11.55	69	36699	15611	34904552
Inappropriate schedule of product administration	45.23	11.55	6	36762	62290	34857873
Blood parathyroid hormone decreased	43.22	11.55	24	36744	1456	34918707
Cytomegalovirus viraemia	41.61	11.55	45	36723	7385	34912778
Pre-engraftment immune reaction	40.37	11.55	11	36757	88	34920075
Hospitalisation	40.09	11.55	6	36762	56896	34863267
Agranulocytosis	39.14	11.55	81	36687	23740	34896423
Blood lactate dehydrogenase increased	38.75	11.55	79	36689	22911	34897252
Fall	38.54	11.55	99	36669	202786	34717377
Leukopenia	37.47	11.55	148	36620	62708	34857455
Tendonitis	37.22	11.55	47	36721	9093	34911070
Rash	35.95	11.55	375	36393	222377	34697786
Cholestasis	35.64	11.55	84	36684	26864	34893299
Toxicity to various agents	35.62	11.55	101	36667	200261	34719902
Thrombocytopenia	35.34	11.55	283	36485	155964	34764199
Anal inflammation	35.03	11.55	20	36748	1280	34918883
Blood bilirubin increased	34.98	11.55	104	36664	38192	34881971
Haemodialysis	34.98	11.55	49	36719	10477	34909686
Platelet count decreased	34.63	11.55	230	36538	119487	34800676
Cellulitis enterococcal	34.45	11.55	10	36758	103	34920060
Aplasia pure red cell	34.10	11.55	37	36731	6095	34914068
Rash maculo-papular	33.70	11.55	85	36683	28366	34891797
Haemoglobin decreased	32.53	11.55	228	36540	120544	34799619
Hepatitis	32.15	11.55	75	36693	23829	34896334
Plasma cell myeloma	31.83	11.55	107	36661	41930	34878233
White blood cell count decreased	31.71	11.55	190	36578	95255	34824908
SARS-CoV-2 test negative	31.05	11.55	17	36751	1003	34919160
Incision site pain	31.03	11.55	21	36747	1817	34918346
Liver transplant rejection	30.61	11.55	22	36746	2097	34918066
Rheumatoid nodule	30.30	11.55	25	36743	2922	34917241
Foetal exposure during pregnancy	29.32	11.55	3	36765	38098	34882065
Sphincter of Oddi dysfunction	28.42	11.55	9	36759	127	34920036
Encephalitis viral	28.32	11.55	17	36751	1195	34918968
C-reactive protein abnormal	28.13	11.55	40	36728	8670	34911493
C-reactive protein increased	28.01	11.55	122	36646	53976	34866187
Toxic skin eruption	27.90	11.55	46	36722	11339	34908824
Osteoporotic fracture	27.26	11.55	16	36752	1079	34919084
HIV infection	26.76	11.55	17	36751	1322	34918841
Red blood cells urine positive	26.63	11.55	19	36749	1790	34918373
Blood antidiuretic hormone increased	26.50	11.55	7	36761	49	34920114
Intentional product use issue	26.44	11.55	15	36753	59801	34860362
Rash pruritic	26.37	11.55	75	36693	26866	34893297
Product use issue	26.34	11.55	17	36751	63199	34856964
Weight increased	25.91	11.55	36	36732	92997	34827166
Intentional overdose	25.79	11.55	7	36761	43667	34876496
Dialysis	25.75	11.55	44	36724	11164	34908999
Intentional product misuse	25.67	11.55	8	36760	45603	34874560
Acquired immunodeficiency syndrome	25.65	11.55	12	36756	506	34919657
Neutrophil count decreased	25.51	11.55	114	36654	50990	34869173
Delayed graft function	25.29	11.55	20	36748	2201	34917962
Kaposi's sarcoma	24.91	11.55	14	36754	869	34919294
Asthma	24.88	11.55	7	36761	42649	34877514
Hypercalcaemia	24.71	11.55	52	36716	15416	34904747
Cerebrovascular accident	24.44	11.55	32	36736	84779	34835384
Proctalgia	24.21	11.55	30	36738	5693	34914470
Lymphocele	24.10	11.55	16	36752	1341	34918822
Skin necrosis	23.68	11.55	30	36738	5823	34914340
Graft versus host disease	23.64	11.55	41	36727	10528	34909635
Pneumonia cytomegaloviral	23.55	11.55	22	36746	3032	34917131
Aspergillus infection	22.93	11.55	44	36724	12210	34907953
Hepatomegaly	22.82	11.55	40	36728	10356	34909807
Body temperature increased	22.81	11.55	54	36714	17314	34902849
Gamma-glutamyltransferase increased	22.65	11.55	75	36693	29156	34891007
Dizziness	22.60	11.55	136	36632	218385	34701778
Renal failure	22.54	11.55	223	36545	130334	34789829
Blood alkaline phosphatase increased	22.41	11.55	78	36690	31097	34889066
Fatigue	22.38	11.55	266	36502	370387	34549776
Dyspnoea	22.14	11.55	272	36496	376510	34543653
Human herpesvirus 6 infection	22.12	11.55	18	36750	2063	34918100
Hepatitis cholestatic	22.07	11.55	34	36734	7913	34912250
Febrile neutropenia	21.84	11.55	230	36538	136619	34783544
SARS-CoV-2 antibody test positive	21.55	11.55	10	36758	414	34919749
Syncope	21.14	11.55	40	36728	91411	34828752
Parvovirus infection	20.92	11.55	10	36758	443	34919720
Chronic lymphocytic leukaemia	20.89	11.55	24	36744	4208	34915955
Culture urine positive	20.85	11.55	14	36754	1196	34918967
Dermatitis exfoliative	20.72	11.55	30	36738	6609	34913554
Drug reaction with eosinophilia and systemic symptoms	20.69	11.55	79	36689	32933	34887230
Serum sickness	20.63	11.55	17	36751	1983	34918180
Injection site pain	19.96	11.55	8	36760	38997	34881166
Clonal haematopoiesis	19.40	11.55	6	36762	78	34920085
Drug hypersensitivity	19.35	11.55	148	36620	80381	34839782
Biopsy liver abnormal	19.35	11.55	7	36761	151	34920012
Bone marrow failure	19.16	11.55	71	36697	29182	34890981
Cytomegalovirus test positive	19.12	11.55	22	36746	3864	34916299
Tubulointerstitial nephritis	19.10	11.55	57	36711	20967	34899196
Cystitis haemorrhagic	18.22	11.55	26	36742	5653	34914510
Arthralgia	18.00	11.55	105	36663	169936	34750227
Hepatosplenomegaly	17.87	11.55	22	36746	4147	34916016
Chills	17.86	11.55	146	36622	80897	34839266
Rash morbilliform	17.82	11.55	19	36749	3068	34917095
Complications of transplanted kidney	17.66	11.55	23	36745	4586	34915577
Renal tubular disorder	17.53	11.55	23	36745	4620	34915543
Wrong technique in product usage process	17.43	11.55	8	36760	35978	34884185
Drug eruption	17.19	11.55	53	36715	19845	34900318
Proteus infection	17.17	11.55	12	36756	1094	34919069
Somnolence	16.91	11.55	60	36708	111056	34809107
Protein urine present	16.87	11.55	24	36744	5204	34914959
Lung infiltration	16.81	11.55	40	36728	12865	34907298
Synovitis	16.63	11.55	42	36726	14024	34906139
Blood immunoglobulin G decreased	16.20	11.55	13	36755	1460	34918703
Culture stool positive	16.16	11.55	7	36761	246	34919917
COVID-19	16.15	11.55	36	36732	77514	34842649
Thrombotic microangiopathy	16.13	11.55	35	36733	10595	34909568
Enterovirus infection	16.02	11.55	11	36757	975	34919188
Blood pressure increased	15.93	11.55	44	36724	88058	34832105
Suicide attempt	15.64	11.55	11	36757	39105	34881058
Myocardial infarction	15.51	11.55	70	36698	121015	34799148
Blood culture positive	15.50	11.55	22	36746	4761	34915402
Cytomegalovirus chorioretinitis	15.48	11.55	19	36749	3570	34916593
Oesophageal candidiasis	15.41	11.55	21	36747	4375	34915788
Lymphadenopathy	15.35	11.55	65	36703	28398	34891765
Granuloma	15.32	11.55	18	36750	3233	34916930
Blood potassium increased	15.25	11.55	45	36723	16450	34903713
Erythema infectiosum	15.19	11.55	6	36762	166	34919997
Leukaemia recurrent	15.16	11.55	13	36755	1602	34918561
Orbital haemorrhage	14.91	11.55	4	36764	30	34920133
Mental status changes	14.73	11.55	79	36689	38004	34882159
HIV wasting syndrome	14.72	11.55	5	36763	89	34920074
Haemorrhoids	14.67	11.55	41	36727	14534	34905629
Therapeutic product effect incomplete	14.63	11.55	19	36749	50522	34869641
Renal cell carcinoma	14.59	11.55	22	36746	5026	34915137
Bronchopulmonary aspergillosis	14.53	11.55	41	36727	14618	34905545
Blood albumin decreased	14.48	11.55	39	36729	13533	34906630
Phlebitis	14.35	11.55	19	36749	3851	34916312
Feeling abnormal	14.31	11.55	28	36740	63207	34856956
Skin exfoliation	14.29	11.55	62	36706	27370	34892793
Vena cava injury	14.18	11.55	7	36761	333	34919830
Psoriasis	14.14	11.55	12	36756	38800	34881363
Hepatic steatosis	14.12	11.55	47	36721	18315	34901848
Rheumatoid lung	14.11	11.55	10	36758	932	34919231
Lymphocytic infiltration	14.09	11.55	9	36759	706	34919457
Acute graft versus host disease in skin	14.09	11.55	22	36746	5179	34914984
Light chain analysis decreased	14.07	11.55	4	36764	38	34920125
Pneumonia pneumococcal	13.81	11.55	14	36754	2132	34918031
Wound evisceration	13.77	11.55	5	36763	109	34920054
Mycobacterium avium complex infection	13.70	11.55	15	36753	2496	34917667
Liver transplant	13.58	11.55	15	36753	2519	34917644
Contusion	13.55	11.55	11	36757	36353	34883810
Hepatitis A antibody positive	13.38	11.55	4	36764	46	34920117
Ulcer	13.30	11.55	29	36739	8806	34911357
Cytomegalovirus test	13.30	11.55	4	36764	47	34920116
Traumatic liver injury	13.03	11.55	6	36762	244	34919919
Optic neuropathy	12.98	11.55	13	36755	1952	34918211
Stent removal	12.97	11.55	3	36765	11	34920152
Product prescribing error	12.93	11.55	4	36764	22923	34897240
Therapeutic product effect prolonged	12.78	11.55	6	36762	255	34919908
Cystic lymphangioma	12.76	11.55	3	36765	12	34920151
Product use in unapproved indication	12.72	11.55	72	36696	117427	34802736
Blood bilirubin unconjugated increased	12.71	11.55	8	36760	612	34919551
Respiratory failure	12.69	11.55	172	36596	108400	34811763
Hepatitis B antibody positive	12.66	11.55	4	36764	56	34920107
Epstein-Barr virus infection	12.60	11.55	26	36742	7602	34912561
Idiopathic pneumonia syndrome	12.59	11.55	6	36762	264	34919899
Prostate cancer	12.43	11.55	14	36754	39635	34880528
Anaemia	12.36	11.55	327	36441	233008	34687155
Enterococcal infection	12.29	11.55	29	36739	9277	34910886
Granulomatous rosacea	12.25	11.55	5	36763	151	34920012
Autoimmune haemolytic anaemia	12.16	11.55	19	36749	4477	34915686
Hepatitis C virus test	12.05	11.55	4	36764	66	34920097
Blood chloride increased	12.02	11.55	15	36753	2866	34917297
Haematocrit decreased	11.90	11.55	66	36702	32150	34888013
Refusal of treatment by patient	11.88	11.55	20	36748	5012	34915151
Nasopharyngitis	11.87	11.55	36	36732	69932	34850231
Accident	11.84	11.55	20	36748	5027	34915136
Hepatic enzyme increased	11.83	11.55	76	36692	39004	34881159
Epidermal necrosis	11.76	11.55	7	36761	484	34919679
Rectal prolapse	11.75	11.55	7	36761	485	34919678
Immunosuppressant drug level increased	11.64	11.55	22	36746	6033	34914130
Haemoglobinaemia	11.64	11.55	5	36763	172	34919991

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Muscle injury	1147.05	11.58	722	96233	47839	79599594
Folliculitis	1122.74	11.58	748	96207	54632	79592801
Sleep disorder due to general medical condition, insomnia type	1092.90	11.58	673	96282	42883	79604550
Irritable bowel syndrome	1013.90	11.58	735	96220	61506	79585927
Impaired healing	798.75	11.58	738	96217	86917	79560516
Duodenal ulcer perforation	746.20	11.58	629	96326	65582	79581851
Helicobacter infection	702.05	11.58	621	96334	69083	79578350
Gastrointestinal disorder	687.45	11.58	794	96161	121411	79526022
Blister	678.34	11.58	780	96175	118696	79528737
Stomatitis	585.29	11.58	803	96152	145954	79501479
Lower respiratory tract infection	570.33	11.58	743	96212	128477	79518956
Ill-defined disorder	535.71	11.58	521	96434	65354	79582079
Anti-cyclic citrullinated peptide antibody positive	530.31	11.58	577	96378	82566	79564867
Pericarditis	505.12	11.58	628	96327	103608	79543825
Pemphigus	503.59	11.58	613	96342	98969	79548464
Hand deformity	487.46	11.58	616	96339	103303	79544130
Glossodynia	466.48	11.58	601	96354	102736	79544697
Synovitis	452.69	11.58	722	96233	150012	79497421
Discomfort	435.28	11.58	643	96312	124974	79522459
Systemic lupus erythematosus	432.61	11.58	629	96326	120520	79526913
Therapeutic product effect decreased	431.77	11.58	740	96215	163123	79484310
Infection	426.97	11.58	921	96034	240791	79406642
Sinusitis	407.80	11.58	798	96157	194703	79452730
Arthropathy	380.38	11.58	732	96223	176379	79471054
Wound	354.88	11.58	561	96394	115618	79531815
Swelling	340.17	11.58	788	96167	215923	79431510
Hepatic enzyme increased	337.46	11.58	709	96246	181901	79465532
Hypersensitivity	332.86	11.58	879	96076	261360	79386073
Pyrexia	324.86	11.58	1654	95301	677055	78970378
Contraindicated product administered	287.89	11.58	609	96346	156929	79490504
Confusional state	277.98	11.58	934	96021	317063	79330370
Contusion	274.01	11.58	577	96378	148199	79499234
Death	274.00	11.58	176	96779	566338	79081095
Infusion related reaction	266.28	11.58	746	96209	229491	79417942
Nasopharyngitis	247.32	11.58	774	96181	253107	79394326
Completed suicide	242.38	11.58	14	96941	245753	79401680
Peripheral swelling	240.92	11.58	798	96157	268819	79378614
Fall	233.63	11.58	153	96802	487476	79159957
Abdominal discomfort	231.99	11.58	751	96204	249976	79397457
Weight increased	224.20	11.58	794	96161	276592	79370841
Joint swelling	219.53	11.58	810	96145	287836	79359597
Drug intolerance	213.41	11.58	756	96199	263363	79384070
Product dose omission issue	204.49	11.58	29	96926	247508	79399925
Alopecia	201.47	11.58	679	96276	230676	79416757
Toxicity to various agents	196.82	11.58	136	96819	421404	79226029
Rheumatoid arthritis	186.06	11.58	617	96338	207853	79439580
Rash	172.68	11.58	1248	95707	577110	79070323
Pruritus	171.69	11.58	938	96017	393710	79253723
Drug abuse	167.60	11.58	7	96948	162684	79484749
Off label use	150.98	11.58	581	96374	906634	78740799
Pre-engraftment immune reaction	129.60	11.58	37	96918	304	79647129
Deep vein thrombosis postoperative	118.62	11.58	101	96854	10651	79636782
Maternal exposure during pregnancy	117.19	11.58	399	96556	136139	79511294
Alanine aminotransferase abnormal	113.93	11.58	91	96864	8776	79638657
Injection site pain	112.51	11.58	13	96942	129825	79517608
Dizziness	108.08	11.58	307	96648	526134	79121299
Red blood cell sedimentation rate	105.05	11.58	72	96883	5493	79641940
Autoimmune disorder	101.81	11.58	113	96842	16499	79630934
Pregnancy	100.94	11.58	143	96812	26708	79620725
Blood pressure increased	98.76	11.58	68	96887	211292	79436141
Enthesopathy	96.50	11.58	93	96862	11515	79635918
Tongue disorder	96.05	11.58	101	96854	13874	79633559
Intentional overdose	95.95	11.58	9	96946	105951	79541482
Tenosynovitis	95.66	11.58	106	96849	15448	79631985
Therapy non-responder	90.21	11.58	282	96673	92023	79555410
Inappropriate schedule of product administration	88.92	11.58	26	96929	133602	79513831
Encephalitis viral	88.85	11.58	49	96906	2530	79644903
Cough	87.50	11.58	198	96757	366591	79280842
Pain in extremity	86.79	11.58	197	96758	364341	79283092
Maternal exposure timing unspecified	84.31	11.58	64	96891	5728	79641705
C-reactive protein abnormal	81.37	11.58	181	96774	48186	79599247
COVID-19	80.16	11.58	46	96909	157628	79489805
Feeling abnormal	77.35	11.58	49	96906	159150	79488283
Wrong technique in product usage process	73.41	11.58	4	96951	73871	79573562
Nausea	72.85	11.58	779	96176	956417	78691016
Syncope	71.02	11.58	68	96887	179381	79468052
Blood parathyroid hormone decreased	70.38	11.58	75	96880	10461	79636972
Cytomegalovirus infection	68.85	11.58	157	96798	42487	79604946
Constipation	68.12	11.58	152	96803	282898	79364535
Panniculitis	67.10	11.58	79	96876	12292	79635141
Human herpesvirus 6 infection	66.63	11.58	54	96901	5316	79642117
Psoriasis	66.25	11.58	14	96941	89573	79557860
Malaise	65.32	11.58	340	96615	489529	79157904
Kidney transplant rejection	65.04	11.58	71	96884	10175	79637258
Fear of injection	64.25	11.58	61	96894	7413	79640020
Hypotension	62.48	11.58	299	96656	440018	79207415
Diarrhoea	62.03	11.58	729	96226	879760	78767673
Cerebrovascular accident	61.27	11.58	59	96896	155233	79492200
C-reactive protein	59.53	11.58	49	96906	4930	79642503
Headache	59.42	11.58	509	96446	653263	78994170
Tendonitis	59.20	11.58	105	96850	23725	79623708
Intentional product misuse	58.91	11.58	21	96934	95144	79552289
Myocardial infarction	58.62	11.58	83	96872	184046	79463387
Rheumatoid nodule	58.47	11.58	88	96867	17350	79630083
Clear cell renal cell carcinoma	57.50	11.58	37	96918	2539	79644894
Drug interaction	57.12	11.58	285	96670	414898	79232535
Immune reconstitution inflammatory syndrome	56.95	11.58	77	96878	13764	79633669
Granuloma skin	55.52	11.58	62	96893	9112	79638321
Back pain	55.48	11.58	187	96768	303993	79343440
Oropharyngeal pain	55.43	11.58	32	96923	109321	79538112
Suicide attempt	55.41	11.58	16	96939	82916	79564517
Lip dry	54.85	11.58	80	96875	15338	79632095
Skin necrosis	53.29	11.58	86	96869	18001	79629432
Transplant rejection	51.35	11.58	88	96867	19349	79628084
Blood creatinine increased	50.94	11.58	343	96612	154714	79492719
Nasal congestion	50.73	11.58	15	96940	76537	79570896
Pneumonia	50.62	11.58	536	96419	659710	78987723
Influenza	50.24	11.58	50	96905	129556	79517877
Drug hypersensitivity	50.18	11.58	570	96385	298346	79349087
Balance disorder	50.00	11.58	29	96926	98828	79548605
Injection site erythema	48.84	11.58	17	96938	78180	79569253
Lymphoproliferative disorder	48.59	11.58	46	96909	5569	79641864
Rhinorrhoea	48.45	11.58	16	96939	76058	79571375
Loss of consciousness	48.38	11.58	81	96874	167862	79479571
Stevens-Johnson syndrome	47.21	11.58	129	96826	39037	79608396
Stress	46.89	11.58	19	96936	79593	79567840
Granuloma	46.69	11.58	54	96901	8243	79639190
Injury	46.33	11.58	202	96753	77294	79570139
Aspartate aminotransferase increased	45.72	11.58	307	96648	138334	79509099
Alanine aminotransferase increased	45.50	11.58	346	96609	162224	79485209
Cardio-respiratory arrest	45.44	11.58	39	96916	108471	79538962
Adjustment disorder with depressed mood	44.34	11.58	55	96900	9031	79638402
Haematochezia	43.92	11.58	26	96929	87619	79559814
Atrial fibrillation	42.28	11.58	113	96842	197773	79449660
Hyperkalaemia	41.81	11.58	260	96695	114138	79533295
Cardiac failure congestive	41.64	11.58	68	96887	142334	79505099
Overdose	40.26	11.58	104	96851	184102	79463331
Hyperhidrosis	40.09	11.58	77	96878	151415	79496018
Product prescribing error	40.05	11.58	4	96951	44809	79602624
X-ray abnormal	39.92	11.58	42	96913	5771	79641662
Medication error	39.58	11.58	177	96778	68465	79578968
Illness	39.43	11.58	5	96950	46506	79600927
Palpitations	39.37	11.58	58	96897	126552	79520881
Chronic obstructive pulmonary disease	39.18	11.58	28	96927	85391	79562042
Suicidal ideation	39.17	11.58	22	96933	76318	79571115
Arthralgia	38.78	11.58	939	96016	570864	79076569
Sedation	38.59	11.58	8	96947	51887	79595546
Injection site bruising	38.43	11.58	3	96952	40999	79606434
Neck pain	38.32	11.58	22	96933	75395	79572038
Injection site reaction	37.66	11.58	10	96945	54775	79592658
Chest discomfort	37.55	11.58	69	96886	137975	79509458
Fluid retention	37.46	11.58	19	96936	69790	79577643
Depressed mood	37.04	11.58	7	96948	48473	79598960
Rheumatic fever	36.44	11.58	96	96859	28429	79619004
Serotonin syndrome	35.49	11.58	6	96949	45021	79602412
Somnolence	35.19	11.58	160	96795	238821	79408612
Weight decreased	35.18	11.58	270	96685	354928	79292505
Cardiac failure	34.94	11.58	86	96869	154756	79492677
Psoriatic arthropathy	34.85	11.58	187	96768	77812	79569621
Lower limb fracture	34.77	11.58	83	96872	23132	79624301
Deafness transitory	34.54	11.58	19	96936	976	79646457
Bradycardia	34.07	11.58	71	96884	135486	79511947
Incorrect dose administered	34.01	11.58	26	96929	76604	79570829
Urticaria	33.72	11.58	359	96596	184842	79462591
Injection site swelling	33.57	11.58	8	96947	47124	79600309
Rheumatoid lung	33.39	11.58	33	96922	4212	79643221
Haematemesis	33.27	11.58	11	96944	52253	79595180
Multiple sclerosis relapse	32.94	11.58	8	96947	46525	79600908
Cardiac arrest	32.59	11.58	104	96851	171992	79475441
Urinary tract infection	32.47	11.58	198	96757	274314	79373119
Swollen joint count increased	32.23	11.58	80	96875	22847	79624586
Blood pressure fluctuation	32.14	11.58	21	96934	67124	79580309
Cardiogenic shock	32.14	11.58	6	96949	41908	79605525
Cataract	31.73	11.58	18	96937	62102	79585331
Ulcer	31.53	11.58	94	96861	29878	79617555
Gait disturbance	31.10	11.58	138	96817	207368	79440065
Hot flush	30.88	11.58	14	96941	54863	79592570
Condition aggravated	30.66	11.58	427	96528	500697	79146736
Breast cancer	30.23	11.58	3	96952	33778	79613655
Therapeutic product effect incomplete	30.16	11.58	81	96874	141564	79505869
Visual impairment	29.83	11.58	41	96914	92090	79555343
Gastrointestinal haemorrhage	29.59	11.58	87	96868	147632	79499801
Drug eruption	28.96	11.58	118	96837	43817	79603616
Heart rate increased	28.87	11.58	65	96890	120659	79526774
Facet joint syndrome	28.33	11.58	50	96905	11252	79636181
Anal inflammation	28.18	11.58	19	96936	1411	79646022
Incision site pain	28.02	11.58	25	96930	2805	79644628
Dyspnoea exertional	27.94	11.58	39	96916	87034	79560399
Flushing	27.87	11.58	40	96915	88228	79559205
Renal tubular necrosis	27.75	11.58	80	96875	24959	79622474
Hospitalisation	27.54	11.58	45	96910	94191	79553242
Cytomegalovirus viraemia	27.46	11.58	53	96902	12768	79634665
Drug ineffective for unapproved indication	27.41	11.58	14	96941	51224	79596209
Influenza like illness	27.40	11.58	28	96927	71679	79575754
Adverse event	27.33	11.58	145	96810	60069	79587364
Acute myocardial infarction	27.32	11.58	32	96923	77004	79570429
Pain in jaw	27.20	11.58	11	96944	46140	79601293
Unevaluable event	27.13	11.58	17	96938	55568	79591865
Drug ineffective	27.12	11.58	1058	95897	1079855	78567578
Vomiting	27.11	11.58	610	96345	665218	78982215
Cardiac disorder	27.09	11.58	24	96931	65733	79581700
Hypothyroidism	27.02	11.58	15	96940	52377	79595056
Dysphonia	26.93	11.58	18	96937	56854	79590579
Meningoencephalitis herpetic	26.81	11.58	21	96934	1968	79645465
Limb discomfort	26.74	11.58	4	96951	32846	79614587
Liver disorder	26.71	11.58	165	96790	72252	79575181
Full blood count abnormal	26.69	11.58	8	96947	40466	79606967
Depressed level of consciousness	26.56	11.58	48	96907	96604	79550829
Intentional self-injury	26.27	11.58	4	96951	32415	79615018
Osteonecrosis of jaw	25.97	11.58	10	96945	43216	79604217
Psychotic disorder	25.85	11.58	9	96946	41393	79606040
Bronchitis	25.40	11.58	78	96877	130566	79516867
Drug dependence	25.22	11.58	9	96946	40760	79606673
Haemodialysis	25.13	11.58	63	96892	18105	79629328
Injection site pruritus	25.05	11.58	10	96945	42273	79605160
Road traffic accident	24.72	11.58	112	96843	43552	79603881
Blood urea increased	24.59	11.58	121	96834	48669	79598764
Osteoporosis	24.47	11.58	18	96937	54094	79593339
Oxygen saturation decreased	24.42	11.58	78	96877	128969	79518464
Epistaxis	24.32	11.58	63	96892	111452	79535981
Sleep disorder	24.32	11.58	183	96772	85494	79561939
Heart rate decreased	24.09	11.58	30	96925	70286	79577147
Complications of transplanted kidney	24.06	11.58	34	96921	6332	79641101
Anaphylactic shock	23.94	11.58	7	96948	35989	79611444
Diabetic ketoacidosis	23.89	11.58	6	96949	34116	79613317
Dysphagia	23.69	11.58	73	96882	122063	79525370
Hypertension	23.58	11.58	273	96682	330719	79316714
Drug tolerance decreased	23.45	11.58	50	96905	12928	79634505
Asthenia	23.38	11.58	460	96495	511229	79136204
Muscle spasms	23.38	11.58	121	96834	174609	79472824
Labelled drug-drug interaction medication error	23.37	11.58	3	96952	27647	79619786
Dry skin	23.31	11.58	29	96926	67966	79579467
Tachycardia	23.28	11.58	124	96831	177644	79469789
Liver transplant rejection	23.26	11.58	24	96931	3224	79644209
Malignant neoplasm progression	23.16	11.58	86	96869	135904	79511529
Melaena	23.01	11.58	24	96931	60866	79586567
Aggression	22.98	11.58	17	96938	50941	79596492
Peripheral venous disease	22.88	11.58	56	96899	15853	79631580
Ischaemic stroke	22.86	11.58	6	96949	33125	79614308
Abdominal distension	22.86	11.58	72	96883	119578	79527855
Hypercalcaemia	22.83	11.58	100	96855	38330	79609103
Cognitive disorder	22.76	11.58	31	96924	69895	79577538
Depression	22.29	11.58	163	96792	216627	79430806
SARS-CoV-2 test negative	21.85	11.58	16	96939	1355	79646078
Pancytopenia	21.75	11.58	302	96653	165443	79481990
Cytomegalovirus test positive	21.36	11.58	31	96924	5916	79641517
Wound infection	21.34	11.58	71	96884	23920	79623513
Drug tolerance	21.26	11.58	38	96917	8637	79638796
Pain	21.17	11.58	1052	95903	702750	78944683
Poisoning	20.75	11.58	3	96952	25269	79622164
Throat irritation	20.72	11.58	12	96943	40934	79606499
Surgery	20.67	11.58	7	96948	32759	79614674
Acne	20.62	11.58	4	96951	27186	79620247
Pneumocystis jirovecii pneumonia	20.40	11.58	86	96869	32422	79615011
Rash pruritic	20.33	11.58	153	96802	71476	79575957
Anti-cyclic citrullinated peptide antibody	20.29	11.58	30	96925	5822	79641611
Withdrawal syndrome	20.26	11.58	4	96951	26850	79620583
Arrhythmia	20.11	11.58	27	96928	61245	79586188
Anaphylactic reaction	20.09	11.58	45	96910	83698	79563735
Femur fracture	20.03	11.58	11	96944	38641	79608792
Febrile bone marrow aplasia	19.98	11.58	47	96908	12973	79634460
Speech disorder	19.97	11.58	22	96933	54423	79593010
Agitation	19.76	11.58	59	96896	99656	79547777
Electrocardiogram QT prolonged	19.76	11.58	51	96904	90335	79557098
Cerebral infarction	19.63	11.58	16	96939	45660	79601773
Tooth disorder	19.59	11.58	4	96951	26229	79621204
Vision blurred	19.35	11.58	65	96890	105833	79541600
Disturbance in attention	19.22	11.58	20	96935	50781	79596652
Serum sickness	19.20	11.58	23	96932	3643	79643790
Productive cough	19.19	11.58	50	96905	88281	79559152
Basal cell carcinoma	19.06	11.58	93	96862	37282	79610151
Neuroleptic malignant syndrome	19.00	11.58	5	96950	27554	79619879
Blood antidiuretic hormone increased	18.76	11.58	6	96949	75	79647358
No adverse event	18.68	11.58	11	96944	37181	79610252
Abdominal pain	18.45	11.58	348	96607	389221	79258212
Tremor	18.40	11.58	126	96829	169957	79477476
Hypomagnesaemia	18.28	11.58	18	96937	46893	79600540
Respiratory arrest	18.24	11.58	26	96929	57524	79589909
Swollen tongue	18.19	11.58	15	96940	42555	79604878
Oral pain	18.06	11.58	8	96947	31790	79615643
Anxiety	17.68	11.58	205	96750	248307	79399126
Lupus vulgaris	17.54	11.58	21	96934	3325	79644108
Dislocation of vertebra	17.40	11.58	33	96922	7847	79639586
Heart rate irregular	17.37	11.58	9	96946	32670	79614763
Tinnitus	17.29	11.58	17	96938	44316	79603117
Liver transplant	17.28	11.58	24	96931	4399	79643034
Haematoma	17.13	11.58	23	96932	52172	79595261
Product quality issue	17.10	11.58	10	96945	33930	79613503
Sphincter of Oddi dysfunction	17.08	11.58	9	96946	424	79647009
Paraesthesia	16.98	11.58	135	96820	176188	79471245
Hypokalaemia	16.96	11.58	104	96851	143936	79503497
Musculoskeletal disorder	16.92	11.58	61	96894	21387	79626046
Acquired immunodeficiency syndrome	16.89	11.58	8	96947	299	79647134
Blood pressure decreased	16.87	11.58	63	96892	99403	79548030
Hypoglycaemia	16.81	11.58	65	96890	101529	79545904
Delayed graft function	16.75	11.58	21	96934	3486	79643947
Inflammation	16.71	11.58	181	96774	93572	79553861
Breast cancer stage II	16.70	11.58	33	96922	8087	79639346
Cytomegalovirus test	16.64	11.58	5	96950	50	79647383
Biopsy liver abnormal	16.53	11.58	9	96946	453	79646980
Transient ischaemic attack	16.51	11.58	24	96931	52671	79594762
Prostate cancer	16.48	11.58	10	96945	33258	79614175
Transfusion	16.47	11.58	3	96952	21327	79626106
Pulmonary arterial hypertension	16.33	11.58	7	96948	28359	79619074
Blood bilirubin unconjugated increased	16.30	11.58	12	96943	1025	79646408
Agranulocytosis	16.23	11.58	102	96853	44928	79602505
Myalgia	16.14	11.58	146	96809	185495	79461938
Treatment failure	16.07	11.58	294	96661	170192	79477241
Cephalhaematoma	16.06	11.58	4	96951	18	79647415
Coronary artery disease	15.86	11.58	35	96920	65439	79581994
Blood culture positive	15.84	11.58	33	96922	8396	79639037
Angina pectoris	15.78	11.58	24	96931	51708	79595725
Lung neoplasm malignant	15.77	11.58	7	96948	27785	79619648
Device dislocation	15.62	11.58	6	96949	25964	79621469
Cystitis	15.58	11.58	25	96930	52707	79594726
Device expulsion	15.51	11.58	6	96949	25855	79621578
Perinephric collection	15.50	11.58	8	96947	361	79647072
Lethargy	15.47	11.58	49	96906	81243	79566190
Hypocalcaemia	15.39	11.58	23	96932	49901	79597532
Renal tubular disorder	15.37	11.58	28	96927	6458	79640975
Iron deficiency anaemia	15.32	11.58	6	96949	25666	79621767
Circulatory collapse	15.21	11.58	14	96941	37654	79609779
Dysgeusia	15.17	11.58	29	96926	57148	79590285
Drug withdrawal syndrome	15.12	11.58	12	96943	34706	79612727
Nephrolithiasis	15.06	11.58	26	96929	53265	79594168
HIV wasting syndrome	15.05	11.58	5	96950	71	79647362
Fracture	14.94	11.58	4	96951	21797	79625636
Dysarthria	14.90	11.58	38	96917	67584	79579849
Flatulence	14.87	11.58	18	96937	42706	79604727
Musculoskeletal discomfort	14.87	11.58	3	96952	19832	79627601
Obstructive airways disorder	14.84	11.58	10	96945	31449	79615984
Urinary retention	14.79	11.58	29	96926	56601	79590832
Bursitis	14.71	11.58	84	96871	35760	79611673
Liver function test increased	14.67	11.58	16	96939	39757	79607676
Swollen joint count	14.62	11.58	12	96943	1203	79646230
Rhabdomyolysis	14.60	11.58	70	96885	103061	79544372
Dystonia	14.53	11.58	4	96951	21395	79626038
Limb injury	14.45	11.58	9	96946	29519	79617914
Orbital haemorrhage	14.45	11.58	4	96951	29	79647404
Liver injury	14.45	11.58	118	96837	56496	79590937
Drug reaction with eosinophilia and systemic symptoms	14.35	11.58	130	96825	64114	79583319
Vertigo	14.33	11.58	40	96915	69042	79578391
Culture urine positive	14.33	11.58	22	96933	4413	79643020
Blood lactate dehydrogenase increased	14.29	11.58	89	96866	39081	79608352
Unresponsive to stimuli	14.20	11.58	29	96926	55759	79591674
Renal impairment	14.19	11.58	123	96832	157660	79489773
Chronic lymphocytic leukaemia	14.15	11.58	23	96932	4843	79642590
Dialysis	14.14	11.58	52	96903	18410	79629023
Lung disorder	14.11	11.58	155	96800	80402	79567031
Intestinal obstruction	14.07	11.58	19	96936	43001	79604432
Night sweats	14.07	11.58	110	96845	51985	79595448
Culture stool positive	14.06	11.58	9	96946	612	79646821
Bronchopulmonary aspergillosis	14.00	11.58	59	96896	22235	79625198
Cystitis haemorrhagic	13.96	11.58	33	96922	9139	79638294
Disease progression	13.93	11.58	150	96805	184212	79463221
Neoplasm progression	13.90	11.58	26	96929	51656	79595777
Skin ulcer	13.89	11.58	113	96842	54037	79593396
Product administration error	13.88	11.58	11	96944	31835	79615598
Lacrimation increased	13.84	11.58	5	96950	22472	79624961
Red blood cells urine positive	13.81	11.58	23	96932	4940	79642493
Eye pruritus	13.68	11.58	4	96951	20566	79626867
Trimethylaminuria	13.59	11.58	6	96949	190	79647243
Gait inability	13.56	11.58	120	96835	58797	79588636
Dermatitis exfoliative	13.38	11.58	36	96919	10793	79636640
Tumour flare	13.32	11.58	11	96944	1112	79646321
Herpes zoster	13.28	11.58	63	96892	93020	79554413
Blood creatine phosphokinase increased	13.17	11.58	39	96916	66051	79581382
Poor venous access	13.08	11.58	3	96952	18146	79629287
Therapeutic response unexpected	13.04	11.58	4	96951	19942	79627491
Granulomatous rosacea	13.04	11.58	6	96949	210	79647223
Vena cava injury	12.99	11.58	7	96948	345	79647088
Graft versus host disease	12.95	11.58	44	96911	14982	79632451
Chemotherapeutic drug level increased	12.90	11.58	7	96948	350	79647083
Burning sensation	12.88	11.58	33	96922	58599	79588834
Restlessness	12.85	11.58	23	96932	46469	79600964
Purpura senile	12.80	11.58	8	96947	522	79646911
Altered state of consciousness	12.73	11.58	21	96934	43801	79603632
Tarsal tunnel syndrome	12.71	11.58	8	96947	528	79646905
Cellulitis enterococcal	12.58	11.58	4	96951	49	79647384
Blood pressure diastolic decreased	12.48	11.58	11	96944	30205	79617228
Diverticulitis	12.45	11.58	23	96932	45913	79601520
Complications of transplant surgery	12.44	11.58	9	96946	748	79646685
Pulmonary fibrosis	12.39	11.58	94	96861	44018	79603415
Anaemia	12.33	11.58	430	96525	444585	79202848
Rash maculo-papular	12.28	11.58	113	96842	55965	79591468
Hallucination	12.25	11.58	58	96897	85687	79561746
Wound evisceration	12.14	11.58	5	96950	133	79647300
Sleep apnoea syndrome	12.04	11.58	16	96939	36462	79610971
Acute respiratory failure	11.96	11.58	35	96920	59506	79587927
Hernia	11.94	11.58	3	96952	17056	79630377
Localised infection	11.88	11.58	17	96938	37558	79609875
Intervertebral disc protrusion	11.84	11.58	7	96948	23614	79623819
Aplasia pure red cell	11.78	11.58	28	96927	7782	79639651
Lymphocyte count decreased	11.76	11.58	98	96857	47191	79600242
Nervousness	11.72	11.58	14	96941	33401	79614032
Lactic acidosis	11.65	11.58	45	96910	70314	79577119

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01EC01	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Intermediate-acting sulfonamides
ATC	J01EE01	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC	J04AM08	ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis
FDA CS	M0020790	Sulfonamides
FDA EPC	N0000175504	Sulfonamide Antimicrobial
MeSH PA	D000890	Anti-Infective Agents
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50183	P450 inhibitors
CHEBI has role	CHEBI:50502	dihydropteroate synthase inhibitors
CHEBI has role	CHEBI:53000	epitope role
CHEBI has role	CHEBI:74234	sepiapterin reductase inhibitors
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:88188	allergenic drug
FDA MoA	N0000185504	Cytochrome P450 2C9 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute otitis media	indication	3110003
Haemophilus Influenzae Acute Otitis Media	indication	19021002
Nocardiosis	indication	29227009	DOID:2312
Shigellosis	indication	36188001
Klebsiella cystitis	indication	60867007
Toxoplasmosis	indication	187192000	DOID:9965
Chlamydial conjunctivitis	indication	231861005	DOID:13800
Escherichia coli urinary tract infection	indication	301011002
Proteus urinary tract infection	indication	301012009
Bacterial urinary infection	indication	312124009
Infective otitis media	indication	312218008
Pneumocystosis jiroveci pneumonia	indication	415125002	DOID:11339
Acute exacerbation of chronic bronchitis	indication	425748003
Haemophilus Influenzae Chronic Bronchitis	indication
Aerobic Gram-Positive Cocci Infection	indication
Pneumocystis Carinii Pneumonia Prevention	indication
Aerobic Gram-Negative Bacillary Infection	indication
Morganella Morganii Urinary Tract Infection	indication
Streptococcus Pneumoniae Chronic Bronchitis	indication
Typhoid fever	off-label use	4834000	DOID:13258
Infection of skin AND/OR subcutaneous tissue	off-label use	19824006
Pertussis	off-label use	27836007
Granuloma inguinale	off-label use	28867007	DOID:9113
Listeria meningitis	off-label use	31568009	DOID:11572
Sinusitis	off-label use	36971009
Whipple's disease	off-label use	41545003	DOID:8476
Bacterial pneumonia	off-label use	53084003	DOID:874
Paracoccidioidomycosis	off-label use	59925007	DOID:12662
Cholera	off-label use	63650001	DOID:1498
Brucellosis	off-label use	75702008	DOID:11077
Paratyphoid fever	off-label use	85904008	DOID:3055
Chlamydial infection	off-label use	105629000
Infection of bone	off-label use	111253001
Meningococcus carrier	off-label use	170486006
Lymphogranuloma venereum	off-label use	186946009	DOID:13819
Chancroid	off-label use	266143009	DOID:13778
Diverticulitis of gastrointestinal tract	off-label use	271366000
Bacterial endocarditis	off-label use	301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome	off-label use	421666009
Diabetic Foot Infection	off-label use
Toxoplasmosis Prevention	off-label use
Postexposure Plague Prophylaxis	off-label use
Chronic Bacterial Prostatitis	off-label use
Glomerulonephritis	contraindication	36171008	DOID:2921
Acute hepatitis	contraindication	37871000
Third trimester pregnancy	contraindication	41587001
Uremia	contraindication	44730006	DOID:4676
Megaloblastic anemia due to folate deficiency	contraindication	85649008	DOID:14026
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Folic acid deficiency	contraindication	190633005
Disease of liver	contraindication	235856003	DOID:409
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Pseudomembranous enterocolitis	contraindication	397683000
Porphyria	contraindication	418470004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.79	acidic
pKa2	2.08	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR	IC50	5.33		CHEMBL	CHEMBL
Bifunctional protein FolC	Enzyme		FOLC_ECOLI					WOMBAT-PK
Dihydrofolate reductase	Enzyme		DYR_PNECA		IC50	7		CHEMBL
Pol polyprotein	Enzyme		Q72874_9HIV1		Ki	8		CHEMBL
Endothelin-1 receptor	GPCR		EDNRA_RAT		IC50	5.40		CHEMBL

External reference:

ID	Source
4017734	VUID
N0000146102	NUI
D00447	KEGG_DRUG
4017734	VANDF
C0038689	UMLSCUI
CHEBI:9332	CHEBI
08D	PDB_CHEM_ID
CHEMBL443	ChEMBL_ID
DB01015	DRUGBANK_ID
D013420	MESH_DESCRIPTOR_UI
5329	PUBCHEM_CID
10933	IUPHAR_LIGAND_ID
1386	INN_ID
JE42381TNV	UNII
10180	RXNORM
2035	MMSL
5526	MMSL
d00119	MMSL
002827	NDDF
363528007	SNOMEDCT_US
70047000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0853	SUSPENSION	200 mg	ORAL	NDA	28 sections
SULFATRIM	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0854	SUSPENSION	200 mg	ORAL	NDA	29 sections
SULFATRIM	HUMAN PRESCRIPTION DRUG LABEL	2	0121-0854	SUSPENSION	200 mg	ORAL	NDA	29 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0121-4793	SUSPENSION	200 mg	ORAL	ANDA	28 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0440-2406	TABLET	800 mg	ORAL	ANDA	13 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0527-5180	SUSPENSION	200 mg	ORAL	ANDA	21 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0527-5180	SUSPENSION	200 mg	ORAL	ANDA	21 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0527-5181	SUSPENSION	200 mg	ORAL	ANDA	21 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0527-5181	SUSPENSION	200 mg	ORAL	ANDA	21 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0615-8121	TABLET	800 mg	ORAL	ANDA	26 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9503	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9503	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9503	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9514	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9526	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9526	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0703-9526	INJECTION, SOLUTION, CONCENTRATE	80 mg	INTRAVENOUS	ANDA	31 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	0904-2725	TABLET	800 mg	ORAL	ANDA	13 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	10544-053	TABLET	800 mg	ORAL	ANDA	26 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	10544-092	TABLET	800 mg	ORAL	ANDA	25 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	10544-525	TABLET	800 mg	ORAL	ANDA	13 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	10544-926	TABLET	800 mg	ORAL	ANDA	13 sections
Sulfamethoxazole and Trimethoprim	HUMAN PRESCRIPTION DRUG LABEL	2	10544-940	TABLET	800 mg	ORAL	ANDA	27 sections
Sulfamethoxazole and Trimethoprim DS	HUMAN PRESCRIPTION DRUG LABEL	2	12634-177	TABLET	800 mg	ORAL	ANDA	21 sections
SULFAMETHOXAZOLE and TRIMETHOPRIM	HUMAN PRESCRIPTION DRUG LABEL	2	12634-779	SUSPENSION	200 mg	ORAL	ANDA	21 sections