sulfacetamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2497	144-80-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulfacetamide acetosulfamin acetosulfamine formosulfacetamide N-Acetylsulfanilamide N-Sulfanilylacetamide sulfacet sulfacetimide sulphacetamide sulfacetamide sodium sulfacetamide sodic hydrate	An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections. Molecular weight: 214.24 Formula: C8H10N2O3S CLOGP: -0.98 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 89.26 ALOGS: -1.71 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulfacetamide
acetosulfamin
acetosulfamine
formosulfacetamide
N-Acetylsulfanilamide
N-Sulfanilylacetamide
sulfacet
sulfacetimide
sulphacetamide
sulfacetamide sodium
sulfacetamide sodic hydrate

An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections.

Molecular weight: 214.24
Formula: C8H10N2O3S
CLOGP: -0.98
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 89.26
ALOGS: -1.71
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 12, 1945	FDA	ORTHO MCNEIL PHARM

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	414.01	42.71	169	1047	310518	63177288
Bronchiectasis	160.38	42.71	41	1175	16101	63471705
Bone erosion	156.60	42.71	41	1175	17676	63470130
Hypothyroidism	125.02	42.71	42	1174	42590	63445216
Loss of personal independence in daily activities	88.24	42.71	41	1175	97249	63390557
Neutropenia	68.16	42.71	42	1174	174963	63312843
Synovitis	58.24	42.71	39	1177	186879	63300927
Hypersensitivity	57.11	42.71	46	1170	292639	63195167
Red blood cell sedimentation rate abnormal	52.00	42.71	18	1198	19764	63468042
Drug intolerance	50.84	42.71	44	1172	308617	63179189

Showing 1 to 10 of 10 entries

Previous1Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	38.16	34.17	14	143	80515	34876259

Showing 1 to 1 of 1 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	248.84	31.24	103	881	298813	79444591
Bone erosion	98.61	31.24	26	958	17821	79725583
Bronchiectasis	92.78	31.24	26	958	22360	79721044
Hypothyroidism	71.03	31.24	26	958	52366	79691038
Loss of personal independence in daily activities	54.16	31.24	26	958	102554	79640850
Joint stiffness	50.65	31.24	19	965	40811	79702593
Synovitis	44.74	31.24	26	958	150708	79592696
Neutropenia	35.79	31.24	29	955	287681	79455723
Drug intolerance	33.64	31.24	27	957	264092	79479312

Showing 1 to 9 of 9 entries

Previous1Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	D10AF06	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Antiinfectives for treatment of acne
ATC	S01AB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Sulfonamides
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:50502	dihydropteroate synthase inhibitors
CHEBI has role	CHEBI:36047	antibacterial drugs
FDA CS	M0020790	Sulfonamides
FDA EPC	N0000175503	Sulfonamide Antibacterial
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents

Showing 1 to 10 of 12 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Trachoma	indication	2576002	DOID:11265
Seborrheic dermatitis	indication	50563003	DOID:8741
Vulvovaginitis	indication	53277000	DOID:2273
Blepharoconjunctivitis	indication	68659002	DOID:2456
Iridocyclitis	indication	77971008
Acne vulgaris	indication	88616000
Amebic infection	indication	111910009	DOID:9181
Uveitis	indication	128473001	DOID:13141
Pityriasis simplex	indication	200767005
Chlamydial conjunctivitis	indication	231861005	DOID:13800

Showing 1 to 10 of 48 entries

Previous1 2 3 4 5Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.48	acidic
pKa2	1.93	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Dihydrofolate reductase	Enzyme	P00374	DYR_HUMAN		IC50	4.74	CHEMBL
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR			CHEMBL	CHEMBL
Dihydrofolate reductase	Enzyme		DYR_BOVIN		IC50	4.66	CHEMBL

Showing 1 to 3 of 3 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
002821	NDDF
004890	NDDF
10169	RXNORM
108867000	SNOMEDCT_US
122	INN_ID
12509	MMSL
12633	IUPHAR_LIGAND_ID
23827009	SNOMEDCT_US
372676007	SNOMEDCT_US
4018203	VANDF

Showing 1 to 10 of 26 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
Avar-e	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0470	CREAM	100 mg	TOPICAL	unapproved drug other	12 sections
Avar-e Green	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0460	CREAM	100 mg	TOPICAL	unapproved drug other	13 sections
Avar-e LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0465	CREAM	100 mg	TOPICAL	unapproved drug other	12 sections
BLEPH-10	HUMAN PRESCRIPTION DRUG LABEL	1	11980-011	SOLUTION/ DROPS	100 mg	OPHTHALMIC	ANDA	19 sections
BLEPHAMIDE	HUMAN PRESCRIPTION DRUG LABEL	2	0023-0313	OINTMENT	100 mg	OPHTHALMIC	ANDA	19 sections
BLEPHAMIDE	HUMAN PRESCRIPTION DRUG LABEL	2	11980-022	SUSPENSION/ DROPS	100 mg	OPHTHALMIC	NDA	20 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next