sulfacetamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2497	144-80-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulfacetamide acetosulfamin acetosulfamine formosulfacetamide N-Acetylsulfanilamide N-Sulfanilylacetamide sulfacet sulfacetimide sulphacetamide sulfacetamide sodium sulfacetamide sodic hydrate	An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections. Molecular weight: 214.24 Formula: C8H10N2O3S CLOGP: -0.98 LIPINSKI: 0 HAC: 5 HDO: 2 TPSA: 89.26 ALOGS: -1.71 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulfacetamide
acetosulfamin
acetosulfamine
formosulfacetamide
N-Acetylsulfanilamide
N-Sulfanilylacetamide
sulfacet
sulfacetimide
sulphacetamide
sulfacetamide sodium
sulfacetamide sodic hydrate

An anti-bacterial agent that is used topically to treat skin infections and orally for urinary tract infections.

Molecular weight: 214.24
Formula: C8H10N2O3S
CLOGP: -0.98
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 89.26
ALOGS: -1.71
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 12, 1945	FDA	ORTHO MCNEIL PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	414.01	42.71	169	1047	310518	63177288
Bronchiectasis	160.38	42.71	41	1175	16101	63471705
Bone erosion	156.60	42.71	41	1175	17676	63470130
Hypothyroidism	125.02	42.71	42	1174	42590	63445216
Loss of personal independence in daily activities	88.24	42.71	41	1175	97249	63390557
Neutropenia	68.16	42.71	42	1174	174963	63312843
Synovitis	58.24	42.71	39	1177	186879	63300927
Hypersensitivity	57.11	42.71	46	1170	292639	63195167
Red blood cell sedimentation rate abnormal	52.00	42.71	18	1198	19764	63468042
Drug intolerance	50.84	42.71	44	1172	308617	63179189

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	38.16	34.17	14	143	80515	34876259

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	248.84	31.24	103	881	298813	79444591
Bone erosion	98.61	31.24	26	958	17821	79725583
Bronchiectasis	92.78	31.24	26	958	22360	79721044
Hypothyroidism	71.03	31.24	26	958	52366	79691038
Loss of personal independence in daily activities	54.16	31.24	26	958	102554	79640850
Joint stiffness	50.65	31.24	19	965	40811	79702593
Synovitis	44.74	31.24	26	958	150708	79592696
Neutropenia	35.79	31.24	29	955	287681	79455723
Drug intolerance	33.64	31.24	27	957	264092	79479312

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D10AF06	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Antiinfectives for treatment of acne
ATC	S01AB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Sulfonamides
FDA CS	M0020790	Sulfonamides
FDA EPC	N0000175503	Sulfonamide Antibacterial
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D000892	Anti-Infective Agents, Urinary
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:35441	antiinfective agents
CHEBI has role	CHEBI:50502	dihydropteroate synthase inhibitors
CHEBI has role	CHEBI:36047	antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Trachoma	indication	2576002	DOID:11265
Seborrheic dermatitis	indication	50563003	DOID:8741
Vulvovaginitis	indication	53277000	DOID:2273
Blepharoconjunctivitis	indication	68659002	DOID:2456
Iridocyclitis	indication	77971008
Acne vulgaris	indication	88616000
Amebic infection	indication	111910009	DOID:9181
Uveitis	indication	128473001	DOID:13141
Pityriasis simplex	indication	200767005
Chlamydial conjunctivitis	indication	231861005	DOID:13800
Infective blepharitis	indication	312219000
Superficial Ocular Infection	indication
Gardnerella Vaginalis Bacterial Vaginosis	indication
Bacterial conjunctivitis	off-label use	128350005	DOID:9700
Bacterial keratitis	off-label use	314557000
Rosacea	off-label use	398909004	DOID:8881
Ocular hypertension	contraindication	4210003	DOID:9282
Herpes simplex keratitis	contraindication	9389005
Herpes simplex dendritic keratitis	contraindication	29943008
Fungal infection of eye	contraindication	31194008
Severe myopia	contraindication	34187009
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001
Tuberculosis of eye	contraindication	49107007
Heart disease	contraindication	56265001	DOID:114
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Open-angle glaucoma	contraindication	84494001	DOID:1067
Krukenberg spindle	contraindication	85430004
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Eye infection	contraindication	128351009
Bacterial infection of eye	contraindication	128984004
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Arterial aneurysm	contraindication	233981004
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Eruption of skin	contraindication	271807003	DOID:0050486
Viral eye infection	contraindication	312132001
Skin irritation	contraindication	367466007
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Vaccinia keratitis	contraindication	397552005
Breastfeeding (mother)	contraindication	413712001
Disorder of coronary artery	contraindication	414024009
Denuded skin	contraindication	418242004
Porphyria	contraindication	418470004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.48	acidic
pKa2	1.93	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Dihydrofolate reductase	Enzyme	P00374	DYR_HUMAN		IC50	4.74	CHEMBL
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR			CHEMBL	CHEMBL
Dihydrofolate reductase	Enzyme		DYR_BOVIN		IC50	4.66	CHEMBL

External reference:

ID	Source
4018557	VUID
N0000146877	NUI
D00871	KEGG_DRUG
6209-17-2	SECONDARY_CAS_RN
4018203	VANDF
4018557	VANDF
C0038670	UMLSCUI
CHEBI:63845	CHEBI
CHEMBL455	ChEMBL_ID
DB00634	DRUGBANK_ID
CHEMBL1200416	ChEMBL_ID
CHEMBL1723241	ChEMBL_ID
D013409	MESH_DESCRIPTOR_UI
5320	PUBCHEM_CID
12633	IUPHAR_LIGAND_ID
122	INN_ID
4965G3J0F5	UNII
10169	RXNORM
12509	MMSL
5495	MMSL
7988	MMSL
002821	NDDF
004890	NDDF
108867000	SNOMEDCT_US
23827009	SNOMEDCT_US
372676007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BLEPHAMIDE	HUMAN PRESCRIPTION DRUG LABEL	2	0023-0313	OINTMENT	100 mg	OPHTHALMIC	ANDA	19 sections
Sodium Sulfacetamide	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0484	SOLUTION	100 mg	TOPICAL	Unapproved drug other	18 sections
Avar-e Green	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0460	CREAM	100 mg	TOPICAL	unapproved drug other	13 sections
Avar-e LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0465	CREAM	100 mg	TOPICAL	unapproved drug other	12 sections
Avar-e	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0470	CREAM	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	100 mg	TOPICAL	unapproved drug other	12 sections
OVACE Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0485	SHAMPOO	100 mg	TOPICAL	unapproved drug other	12 sections
OVACE Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0485	SHAMPOO	100 mg	TOPICAL	unapproved drug other	12 sections
OVACE Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0490	LIQUID	100 mg	TOPICAL	unapproved drug other	11 sections
OVACE Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0490	LIQUID	100 mg	TOPICAL	unapproved drug other	11 sections
OvacePlus Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0495	CREAM	100 mg	TOPICAL	unapproved drug other	12 sections
OVACE	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0499	LIQUID	100 mg	TOPICAL	unapproved drug other	12 sections
Ovace Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0620	LOTION	98 mg	TOPICAL	unapproved drug other	12 sections
OVACE PLUS	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0630	LIQUID	100 mg	TOPICAL	unapproved drug other	12 sections
OVACE PLUS	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0630	LIQUID	100 mg	TOPICAL	unapproved drug other	12 sections
Ovace Plus	HUMAN PRESCRIPTION DRUG LABEL	1	0178-0696	AEROSOL, FOAM	98 mg	TOPICAL	unapproved drug other	11 sections
Klaron	HUMAN PRESCRIPTION DRUG LABEL	1	0187-5198	LOTION	100 mg	TOPICAL	NDA	16 sections
Sulfacetamide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0574-4190	OINTMENT	100 mg	OPHTHALMIC	ANDA	20 sections
BLEPH-10	HUMAN PRESCRIPTION DRUG LABEL	1	11980-011	SOLUTION/ DROPS	100 mg	OPHTHALMIC	ANDA	19 sections
BLEPHAMIDE	HUMAN PRESCRIPTION DRUG LABEL	2	11980-022	SUSPENSION/ DROPS	100 mg	OPHTHALMIC	NDA	20 sections
Sodium Sulfacetamide and Sulfur	HUMAN PRESCRIPTION DRUG LABEL	2	13925-161	SOLUTION	100 mg	TOPICAL	unapproved drug other	10 sections
Sodium Sulfacetamide	HUMAN PRESCRIPTION DRUG LABEL	1	16477-410	LIQUID	100 mg	TOPICAL	unapproved drug other	19 sections
Sodium Sulfacetamide	HUMAN PRESCRIPTION DRUG LABEL	1	16477-410	LIQUID	100 mg	TOPICAL	unapproved drug other	19 sections
SULFACETAMIDE SODIUM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-209	SOLUTION/ DROPS	100 mg	OPHTHALMIC	ANDA	10 sections
Sulfacetamide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	17478-221	SOLUTION/ DROPS	100 mg	OPHTHALMIC	ANDA	20 sections
Sulfacetamide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	17478-242	SOLUTION/ DROPS	300 mg	OPHTHALMIC	ANDA	20 sections
Sulfacetamide Sodium and Prednisolone Sodium Phosphate	HUMAN PRESCRIPTION DRUG LABEL	2	21695-186	SOLUTION	100 mg	OPHTHALMIC	ANDA	18 sections