succinylsulfathiazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2490 116-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • succinylsulfathiazole
  • cremosuxidine
  • kaoxidin
  • kaoxidine
  • succinylsulphathiazole
  • sulfadigesin
  • sulfasuccidin
  • sulfasuccidine
  • sulfasuccinil
  • sulfasuccithiazole
  • sulfasuxidine
  • sulfenterone
intestinal antimicrobial agent; structure
  • Molecular weight: 355.38
  • Formula: C13H13N3O5S2
  • CLOGP: 0.73
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 125.46
  • ALOGS: -3.28
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.706 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.495 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.364 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 1.426 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 33.750 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 39.070 % Moderate 0.65
herg hERG pIC50 4.530 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 1.455 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 3.155 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 18.460 % Moderate 0.65
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 51
kinase-selectivity-class AURKA,AXL,BRAF,DDR1,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PDK4,STK33,TEK,TTK 13
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.604 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 3.327 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 49.540 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.449 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 29.040 % Moderate 0.65
rh-clint Rat hepatocyte intrinsic clearance 1.726 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 86.880 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 17.710 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 950.605 uM Moderate 0.65

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AB04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Sulfonamides

Related Drugs by ATC class:

A07AB Sulfonamides 2 drugs
phthalylsulfathiazolesulfaguanidine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.55 acidic
pKa2 6.8 acidic
pKa3 13.28 acidic
pKa4 1.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07060 KEGG_DRUG
C0075470 UMLSCUI
CHEBI:9309 CHEBI
CHEMBL1484857 ChEMBL_ID
DB13580 DRUGBANK_ID
CHEMBL268869 ChEMBL_ID
C009342 MESH_SUPPLEMENTAL_RECORD_UI
5315 PUBCHEM_CID
420 INN_ID
RSS8647O4S UNII
37289 RXNORM
002837 NDDF
64669003 SNOMEDCT_US

Pharmaceutical products:

None