sulfaguanidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2505 57-67-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfaguanidine
  • 4-Aminobenzenesulfonylguanidine
  • abiguanil
  • guamide
  • guanicil
  • guanidan
  • sulfaguanidin
  • sulfaguanil
  • sulfaguine
  • sulfanilguanidine
  • sulfanilylguanidine
  • sulfentidine
  • sulfoguanidine
  • sulfoguanil
  • sulfoguanyl
  • sulfoguenil
  • sulphaguanidine
A sulfanilamide antimicrobial agent that is used to treat enteric infections.
  • Molecular weight: 214.24
  • Formula: C7H10N4O2S
  • CLOGP: -1.24
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 122.06
  • ALOGS: -2.42
  • ROTB: 1

Drug dosage:

DoseUnitRoute
4 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary pain 211.07 137.78 35 535 4438 79739380

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AB03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Sulfonamides
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35441 antiinfective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.59 acidic
pKa2 2.65 Basic
pKa3 0.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prothrombin Enzyme Ki 7.02 CHEMBL
Trypsin Enzyme Ki 5.87 CHEMBL
Protein argonaute-2 Unclassified Kd 4.31 CHEMBL

External reference:

IDSource
N0000166871 NUI
D02437 KEGG_DRUG
C0038681 UMLSCUI
CHEBI:94621 CHEBI
QA9 PDB_CHEM_ID
CHEMBL338802 ChEMBL_ID
DB13726 DRUGBANK_ID
D013414 MESH_DESCRIPTOR_UI
5324 PUBCHEM_CID
12639 IUPHAR_LIGAND_ID
423 INN_ID
15XQ8043FN UNII
10174 RXNORM
002839 NDDF
387500006 SNOMEDCT_US
86939001 SNOMEDCT_US

Pharmaceutical products:

None