All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sevoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
halogenated compounds used as general inhalation anaesthetics	2439	28523-86-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sevoflurane sevoflo sevofluran sevofrane sevorane	A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION. Molecular weight: 200.06 Formula: C4H3F7O CLOGP: 1.83 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 9.23 ALOGS: -2.13 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK	40
kinase-selectivity-class	AXL,GRK2,PDK1,PDK2,PIK3CD,PIK3CG	6
pfas-class	PFAS structural alert (1 = True, 0 = False)	1

Approvals:

Date	Agency	Company	Orphan
June 7, 1995	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Delayed recovery from anaesthesia	495.48	35.71	86	8727	944	90618690
Hypotension	376.76	35.71	285	8528	325112	90294522
Serotonin syndrome	355.83	35.71	135	8678	37752	90581882
Drug interaction	317.10	35.71	241	8572	276212	90343422
Hyperthermia malignant	316.35	35.71	61	8752	1237	90618397
Anaphylactic shock	308.93	35.71	116	8697	31501	90588133
Myoglobin urine present	302.17	35.71	54	8759	708	90618926
Bronchospasm	262.08	35.71	92	8721	20617	90599017
Cardiac arrest	224.73	35.71	135	8678	104800	90514834
Unwanted awareness during anaesthesia	209.12	35.71	36	8777	374	90619260
Bradycardia	200.81	35.71	116	8697	83731	90535903
Amylase increased	186.85	35.71	55	8758	7017	90612617
Anaesthetic complication	185.70	35.71	44	8769	2421	90617213
Toxic encephalopathy	184.02	35.71	57	8756	8642	90610992
Anaesthetic complication neurological	169.32	35.71	33	8780	708	90618926
Apnoea	147.08	35.71	49	8764	9365	90610269
Troponin increased	145.31	35.71	53	8760	13228	90606406
Tachycardia	132.62	35.71	115	8698	157558	90462076
Blood creatine phosphokinase increased	129.11	35.71	64	8749	33959	90585675
Blood potassium increased	128.97	35.71	55	8758	20694	90598940
Phrenic nerve paralysis	126.93	35.71	23	8790	327	90619307
Tracheal deviation	125.65	35.71	22	8791	254	90619380
Blood lactate dehydrogenase increased	123.42	35.71	57	8756	25875	90593759
Oxygen saturation decreased	123.32	35.71	94	8719	107389	90512245
Hypercapnia	121.46	35.71	39	8774	6638	90612996
Ventricular tachycardia	119.75	35.71	55	8758	24653	90594981
Haemodynamic instability	117.93	35.71	44	8769	11695	90607939
Neuromuscular block prolonged	112.65	35.71	23	8790	629	90619005
Stress cardiomyopathy	112.41	35.71	44	8769	13311	90606323
Blood pressure decreased	112.15	35.71	77	8736	74818	90544816
Ventricular fibrillation	110.26	35.71	44	8769	14000	90605634
Diabetes insipidus	107.31	35.71	30	8783	3182	90616452
Rhabdomyolysis	107.12	35.71	65	8748	51191	90568443
Torsade de pointes	106.94	35.71	44	8769	15138	90604496
Dystonia	102.60	35.71	44	8769	16775	90602859
Anaphylactic reaction	99.16	35.71	76	8737	87448	90532186
Respiratory depression	89.28	35.71	39	8774	15536	90604098
Post procedural complication	87.94	35.71	41	8772	19001	90600633
Breast cancer recurrent	87.37	35.71	29	8784	5474	90614160
Airway peak pressure increased	79.66	35.71	16	8797	402	90619232
Alanine aminotransferase increased	77.32	35.71	75	8738	118263	90501371
Laryngospasm	75.38	35.71	23	8790	3310	90616324
Maternal exposure during delivery	72.14	35.71	23	8790	3823	90615811
Recurrence of neuromuscular blockade	71.59	35.71	13	8800	187	90619447
Hypoxia	71.50	35.71	58	8755	72341	90547293
Respiratory acidosis	69.20	35.71	27	8786	8092	90611542
Procedural hypotension	67.69	35.71	18	8795	1582	90618052
Fatigue	67.58	35.71	15	8798	1154008	89465626
Hepatorenal failure	66.07	35.71	15	8798	682	90618952
Cardio-respiratory arrest	65.35	35.71	52	8761	63088	90556546
Circulatory collapse	63.65	35.71	36	8777	24868	90594766
Cyanosis	63.29	35.71	33	8780	19422	90600212
Mydriasis	62.19	35.71	30	8783	14982	90604652
Suspected product quality issue	61.60	35.71	13	8800	419	90619215
Blood lactic acid increased	60.32	35.71	25	8788	8753	90610881
Premature delivery	58.32	35.71	40	8773	38722	90580912
Postoperative delirium	57.90	35.71	11	8802	205	90619429
Neuromuscular blockade	57.89	35.71	12	8801	354	90619280
Agitation postoperative	57.82	35.71	8	8805	14	90619620
Vasoplegia syndrome	57.65	35.71	18	8795	2796	90616838
PCO2 increased	56.63	35.71	15	8798	1298	90618336
Lung hyperinflation	55.60	35.71	15	8798	1393	90618241
Blood pH decreased	55.08	35.71	17	8796	2541	90617093
Carcinoid crisis	54.37	35.71	11	8802	287	90619347
Hypoventilation	53.72	35.71	20	8793	5276	90614358
Diarrhoea	51.42	35.71	14	8799	939176	89680458
Paralysis	50.78	35.71	24	8789	11454	90608180
Therapeutic product effect prolonged	50.76	35.71	11	8802	403	90619231
Acute generalised exanthematous pustulosis	49.66	35.71	25	8788	13678	90605956
PO2 decreased	49.33	35.71	14	8799	1567	90618067
Procedural complication	48.16	35.71	19	8794	5859	90613775
Procedural hypertension	47.22	35.71	10	8803	328	90619306
Status asthmaticus	47.16	35.71	12	8801	887	90618747
Sinus tachycardia	46.66	35.71	31	8782	28482	90591152
Myotonia	46.49	35.71	9	8804	186	90619448
Hepatocellular injury	46.22	35.71	31	8782	28927	90590707
Coma	45.48	35.71	45	8768	72587	90547047
Anuria	44.98	35.71	24	8789	14794	90604840
Exposure during pregnancy	44.97	35.71	82	8731	238328	90381306
Epilepsy with myoclonic-atonic seizures	44.74	35.71	8	8805	105	90619529
Blood bicarbonate decreased	43.83	35.71	15	8798	3104	90616530
Electrocardiogram QT prolonged	43.72	35.71	44	8769	72412	90547222
Pulmonary oedema	43.65	35.71	41	8772	62039	90557595
End-tidal CO2 decreased	41.46	35.71	7	8806	64	90619570
Airway complication of anaesthesia	39.27	35.71	9	8804	427	90619207
Endotracheal intubation complication	38.97	35.71	9	8804	442	90619192
Ventricular extrasystoles	38.92	35.71	21	8792	13229	90606405
Pain	38.32	35.71	25	8788	996316	89623318
End-tidal CO2 increased	36.82	35.71	5	8808	7	90619627
Acute postoperative sialadenitis	36.60	35.71	6	8807	45	90619589
Posterior reversible encephalopathy syndrome	35.85	35.71	24	8789	22315	90597319
Pneumonia	35.83	35.71	9	8804	638050	89981584
Dizziness	35.73	35.71	7	8806	589277	90030357

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	909.68	30.81	186	8176	2472	42610501
Delayed recovery from anaesthesia	330.99	30.81	70	8292	1099	42611874
Cardiac arrest	292.71	30.81	210	8152	109110	42503863
Anaphylactic shock	282.99	30.81	122	8240	23395	42589578
Anaphylactic reaction	243.91	30.81	133	8229	42610	42570363
Bradycardia	225.74	30.81	163	8199	85321	42527652
Anaesthetic complication	224.25	30.81	53	8309	1404	42611569
Hypotension	194.54	30.81	245	8117	257386	42355587
Apnoea	161.85	30.81	60	8302	7743	42605230
Post procedural complication	143.74	30.81	63	8299	12527	42600446
Serotonin syndrome	140.58	30.81	78	8284	25767	42587206
Tachycardia	136.89	30.81	131	8231	100956	42512017
Pulmonary alveolar haemorrhage	130.84	30.81	62	8300	14754	42598219
Anaesthetic complication neurological	130.29	30.81	30	8332	706	42612267
Bronchospasm	123.30	30.81	57	8305	12828	42600145
Ventricular fibrillation	121.76	30.81	75	8287	30048	42582925
Oxygen saturation decreased	121.66	30.81	101	8261	64586	42548387
Nephrogenic diabetes insipidus	121.53	30.81	33	8329	1541	42611432
Negative pressure pulmonary oedema	118.82	30.81	27	8335	598	42612375
Ventricular tachycardia	109.11	30.81	70	8292	30090	42582883
Neuromuscular block prolonged	108.34	30.81	25	8337	594	42612379
Recurrence of neuromuscular blockade	104.10	30.81	21	8341	257	42612716
Blood pressure decreased	97.21	30.81	85	8277	58247	42554726
Diabetes insipidus	89.83	30.81	32	8330	3681	42609292
Laryngospasm	87.84	30.81	27	8335	1961	42611012
Drug interaction	83.35	30.81	170	8192	266829	42346144
Stress cardiomyopathy	82.82	30.81	28	8334	2757	42610216
Procedural complication	78.59	30.81	30	8332	4189	42608784
Electrocardiogram ST segment elevation	78.57	30.81	33	8329	5906	42607067
Metabolic acidosis	75.39	30.81	70	8292	51788	42561185
Unwanted awareness during anaesthesia	73.09	30.81	12	8350	39	42612934
Rhabdomyolysis	72.90	30.81	83	8279	77936	42535037
Hypoxic-ischaemic encephalopathy	72.50	30.81	30	8332	5172	42607801
Tachypnoea	70.31	30.81	47	8315	21615	42591358
Hyperkalaemia	65.87	30.81	80	8282	80378	42532595
End-tidal CO2 increased	62.57	30.81	10	8352	26	42612947
Pulmonary oedema	60.79	30.81	63	8299	53209	42559764
Electrocardiogram ST segment depression	60.25	30.81	22	8340	2715	42610258
Haemodynamic instability	57.76	30.81	34	8328	12523	42600450
Respiratory acidosis	54.35	30.81	26	8336	6305	42606668
Diarrhoea	52.56	30.81	13	8349	460836	42152137
Death	52.39	30.81	14	8348	471171	42141802
Kounis syndrome	52.32	30.81	21	8341	3347	42609626
Pneumonia	47.94	30.81	12	8350	422137	42190836
Anaesthetic complication pulmonary	47.43	30.81	9	8353	78	42612895
Torsade de pointes	46.85	30.81	26	8336	8568	42604405
Sinus arrest	46.23	30.81	17	8345	2139	42610834
Ventricular extrasystoles	45.73	30.81	30	8332	13360	42599613
Blood pressure measurement	45.45	30.81	10	8352	190	42612783
Hyperthermia	44.97	30.81	29	8333	12545	42600428
Extrasystoles	44.59	30.81	20	8342	4189	42608784
Pulseless electrical activity	44.56	30.81	25	8337	8412	42604561
Oculocardiac reflex	44.18	30.81	9	8353	116	42612857
Heart rate increased	43.62	30.81	53	8309	53202	42559771
Hepatorenal failure	42.98	30.81	12	8350	621	42612352
Hypercapnia	42.95	30.81	21	8341	5340	42607633
Spinal cord infarction	42.38	30.81	12	8350	654	42612319
Arteriospasm coronary	42.33	30.81	20	8342	4718	42608255
Procedural haemorrhage	41.68	30.81	17	8345	2824	42610149
Agitation postoperative	41.30	30.81	7	8355	29	42612944
Muscle rigidity	41.14	30.81	27	8335	12032	42600941
Electroencephalogram abnormal	40.82	30.81	17	8345	2975	42609998
Respiratory depression	40.77	30.81	32	8330	18836	42594137
Seizure like phenomena	40.54	30.81	13	8349	1084	42611889
Sodium retention	39.50	30.81	8	8354	100	42612873
Postoperative delirium	39.04	30.81	11	8351	589	42612384
PCO2 increased	37.28	30.81	11	8351	694	42612279
Paroxysmal sympathetic hyperactivity	36.86	30.81	7	8355	61	42612912
Erythema	35.83	30.81	71	8291	108722	42504251
Glossoptosis	34.95	30.81	8	8354	183	42612790
Renin increased	34.20	30.81	8	8354	202	42612771
Prinzmetal angina	33.97	30.81	12	8350	1345	42611628
Hypoventilation	33.81	30.81	16	8346	3786	42609187
Suspected product quality issue	32.81	30.81	8	8354	242	42612731
Dyskinesia	32.55	30.81	32	8330	25358	42587615
Shock	32.40	30.81	34	8328	29087	42583886
Nodal rhythm	31.92	30.81	12	8350	1605	42611368
Atrioventricular block	31.52	30.81	21	8341	9594	42603379
Trismus	31.50	30.81	14	8348	2870	42610103
Pulse absent	31.39	30.81	18	8344	6309	42606664
Acidosis	31.33	30.81	23	8339	12256	42600717
Weight bearing difficulty	31.11	30.81	11	8351	1237	42611736
Carbon dioxide increased	30.90	30.81	11	8351	1261	42611712

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	1115.44	28.14	224	15997	3676	110569402
Anaphylactic shock	571.44	28.14	232	15989	51314	110521764
Anaesthetic complication	559.16	28.14	125	16096	3481	110569597
Hypotension	516.99	28.14	499	15722	523350	110049728
Cardiac arrest	505.78	28.14	330	15891	196423	110376655
Delayed recovery from anaesthesia	485.07	28.14	102	16119	2113	110570965
Serotonin syndrome	431.06	28.14	198	16023	58955	110514123
Bradycardia	375.38	28.14	251	15970	155266	110417812
Bronchospasm	362.19	28.14	144	16077	30095	110542983
Drug interaction	343.14	28.14	393	15828	499790	110073288
Anaphylactic reaction	333.69	28.14	208	16013	114092	110458986
Myoglobin urine present	263.80	28.14	53	16168	867	110572211
Tachycardia	239.64	28.14	225	15996	226420	110346658
Ventricular fibrillation	238.79	28.14	118	16103	41195	110531883
Oxygen saturation decreased	232.75	28.14	189	16032	156793	110416285
Ventricular tachycardia	223.10	28.14	120	16101	49889	110523189
Neuromuscular block prolonged	197.49	28.14	44	16177	1203	110571875
Blood pressure decreased	186.38	28.14	146	16075	114945	110458133
Diabetes insipidus	180.72	28.14	58	16163	6512	110566566
Stress cardiomyopathy	170.99	28.14	70	16151	15736	110557342
Unwanted awareness during anaesthesia	169.03	28.14	32	16189	377	110572701
Pulmonary alveolar haemorrhage	161.00	28.14	72	16149	20078	110553000
Apnoea	159.91	28.14	64	16157	13575	110559503
Negative pressure pulmonary oedema	157.68	28.14	33	16188	666	110572412
Laryngospasm	156.75	28.14	48	16173	4620	110568458
Rhabdomyolysis	151.58	28.14	132	16089	120269	110452809
Haemodynamic instability	149.16	28.14	71	16150	22817	110550261
Anaesthetic complication neurological	144.84	28.14	33	16188	1000	110572078
Torsade de pointes	140.88	28.14	68	16153	22532	110550546
Hypercapnia	140.03	28.14	55	16166	11104	110561974
Respiratory depression	134.92	28.14	74	16147	31927	110541151
Amylase increased	133.90	28.14	55	16166	12464	110560614
Recurrence of neuromuscular blockade	130.59	28.14	26	16195	405	110572673
Nephrogenic diabetes insipidus	130.32	28.14	36	16185	2409	110570669
Fatigue	124.59	28.14	16	16205	1215942	109357136
Dystonia	123.72	28.14	65	16156	25740	110547338
Toxic encephalopathy	123.57	28.14	55	16166	15159	110557919
Procedural complication	118.17	28.14	45	16176	8360	110564718
Respiratory acidosis	115.57	28.14	51	16170	13775	110559303
Tracheal deviation	114.93	28.14	22	16199	276	110572802
Blood creatine phosphokinase increased	112.42	28.14	90	16131	72987	110500091
Phrenic nerve paralysis	111.23	28.14	24	16197	563	110572515
Airway peak pressure increased	108.98	28.14	24	16197	621	110572457
Hepatorenal failure	105.73	28.14	27	16194	1333	110571745
Blood potassium increased	100.62	28.14	62	16159	33187	110539891
Pulmonary oedema	100.58	28.14	97	16124	100562	110472516
Post procedural complication	99.73	28.14	57	16164	26601	110546477
End-tidal CO2 increased	98.21	28.14	15	16206	39	110573039
Arthralgia	97.32	28.14	4	16217	779628	109793450
Diarrhoea	95.27	28.14	25	16196	1139480	109433598
Hypoxia	93.74	28.14	105	16116	129410	110443668
Neuromuscular blockade	89.58	28.14	21	16200	723	110572355
Procedural hypotension	89.41	28.14	27	16194	2478	110570600
Troponin increased	88.79	28.14	55	16166	29711	110543367
Suspected product quality issue	88.66	28.14	20	16201	579	110572499
Postoperative delirium	85.26	28.14	21	16200	894	110572184
Ventricular extrasystoles	83.59	28.14	48	16173	22593	110550485
Hypoxic-ischaemic encephalopathy	81.65	28.14	35	16186	8812	110564266
Metabolic acidosis	81.12	28.14	86	16135	99658	110473420
Cardio-respiratory arrest	80.56	28.14	92	16129	115744	110457334
Electrocardiogram ST segment elevation	80.48	28.14	35	16186	9125	110563953
Extrasystoles	80.39	28.14	34	16187	8284	110564794
Cyanosis	78.83	28.14	51	16170	29690	110543388
Blood lactate dehydrogenase increased	77.70	28.14	59	16162	44275	110528803
Circulatory collapse	77.09	28.14	58	16163	42935	110530143
Hypoventilation	74.68	28.14	32	16189	8049	110565029
Pneumonia	73.64	28.14	19	16202	876695	109696383
PCO2 increased	73.54	28.14	22	16199	1955	110571123
Vasoplegia syndrome	72.45	28.14	28	16193	5411	110567667
Muscle rigidity	68.13	28.14	43	16178	23988	110549090
Tachypnoea	68.10	28.14	52	16169	39343	110533735
Hyperkalaemia	67.32	28.14	91	16130	135705	110437373
Kounis syndrome	66.67	28.14	27	16194	5898	110567180
Fall	66.58	28.14	6	16215	603476	109969602
Carcinoid crisis	63.33	28.14	15	16206	540	110572538
Endotracheal intubation complication	61.64	28.14	16	16205	843	110572235
Arteriospasm coronary	61.64	28.14	29	16192	9071	110564007
Maternal exposure during delivery	60.80	28.14	22	16199	3543	110569535
Airway complication of anaesthesia	60.22	28.14	15	16206	669	110572409
Hyperthermia	60.15	28.14	38	16183	21234	110551844
Alanine aminotransferase increased	59.54	28.14	101	16120	183672	110389406
Procedural hypertension	59.04	28.14	13	16208	336	110572742
Mydriasis	58.73	28.14	38	16183	22119	110550959
Weight decreased	56.40	28.14	3	16218	468054	110105024
Suspected product contamination	56.30	28.14	12	16209	265	110572813
Pulseless electrical activity	55.20	28.14	33	16188	16724	110556354
Procedural haemorrhage	55.18	28.14	23	16198	5404	110567674
Electrocardiogram ST segment depression	55.04	28.14	23	16198	5438	110567640
Paralysis	54.73	28.14	32	16189	15568	110557510
Headache	53.00	28.14	32	16189	882345	109690733
Pain	52.82	28.14	38	16183	954917	109618161
Agitation postoperative	52.13	28.14	9	16212	60	110573018
Cardiac output decreased	51.75	28.14	17	16204	2052	110571026
Death	51.70	28.14	19	16202	698850	109874228
Blood pH decreased	51.58	28.14	21	16200	4648	110568430
Pulse absent	50.04	28.14	27	16194	11265	110561813
Anaesthetic complication pulmonary	49.51	28.14	10	16211	168	110572910
Decreased appetite	49.20	28.14	6	16215	475840	110097238
Acidosis	48.59	28.14	34	16187	22497	110550581
PO2 decreased	48.41	28.14	18	16203	3130	110569948
Dizziness	48.34	28.14	21	16200	698172	109874906
Pain in extremity	48.32	28.14	7	16214	487111	110085967
Drug intolerance	47.76	28.14	3	16218	406509	110166569
Generalised tonic-clonic seizure	47.75	28.14	49	16172	54631	110518447
Peripheral swelling	47.41	28.14	3	16218	404031	110169047
Sinus arrest	46.59	28.14	19	16202	4223	110568855
Blood lactic acid increased	46.58	28.14	29	16192	15792	110557286
Sinus tachycardia	46.54	28.14	44	16177	44449	110528629
Oculocardiac reflex	46.37	28.14	9	16212	122	110572956
Electroencephalogram abnormal	45.94	28.14	21	16200	6152	110566926
Erythema	45.76	28.14	119	16102	291328	110281750
Status asthmaticus	45.18	28.14	13	16208	1008	110572070
Shock	44.96	28.14	47	16174	53541	110519537
Therapeutic product effect prolonged	44.94	28.14	12	16209	706	110572372
Spinal cord infarction	44.25	28.14	13	16208	1085	110571993
Malaise	43.74	28.14	22	16199	671797	109901281
Polyuria	43.55	28.14	29	16192	17709	110555369
Hypernatraemia	43.40	28.14	29	16192	17804	110555274
Atrioventricular block second degree	43.21	28.14	22	16199	8159	110564919
Lung hyperinflation	42.72	28.14	15	16206	2214	110570864
Heart rate increased	42.59	28.14	76	16145	143758	110429320
Anuria	41.77	28.14	32	16189	24309	110548769
Anaesthetic complication cardiac	41.74	28.14	8	16213	101	110572977
Epilepsy with myoclonic-atonic seizures	41.24	28.14	8	16213	108	110572970
Compartment syndrome	40.54	28.14	19	16202	5891	110567187
Respiratory failure	40.22	28.14	94	16127	215238	110357840
Atrioventricular block	40.01	28.14	27	16194	16850	110556228
Myotonia	39.62	28.14	9	16212	269	110572809
Dyskinesia	39.41	28.14	43	16178	51403	110521675
Accelerated idioventricular rhythm	39.18	28.14	9	16212	283	110572795
Blood pressure measurement	38.65	28.14	10	16211	520	110572558
Abdominal pain	37.82	28.14	14	16207	512975	110060103
Seizure like phenomena	37.69	28.14	14	16207	2427	110570651
Acute postoperative sialadenitis	37.49	28.14	7	16214	76	110573002
Acute pulmonary oedema	37.47	28.14	26	16195	16970	110556108
Swelling	37.34	28.14	4	16217	351037	110222041
Infection	36.38	28.14	5	16216	362195	110210883
End-tidal CO2 decreased	36.33	28.14	7	16214	91	110572987
Trismus	35.60	28.14	18	16203	6578	110566500
Post procedural stroke	35.22	28.14	7	16214	108	110572970
Trigemino-cardiac reflex	34.90	28.14	9	16212	462	110572616
Long QT syndrome	34.30	28.14	18	16203	7100	110565978
Upper airway obstruction	34.06	28.14	12	16209	1790	110571288
Neutropenia	33.60	28.14	7	16214	374613	110198465
Chemical peritonitis	33.54	28.14	8	16213	297	110572781
Product dose omission issue	33.38	28.14	4	16217	321778	110251300
Electrocardiogram QT prolonged	32.80	28.14	58	16163	108902	110464176
Agitation	32.52	28.14	59	16162	112992	110460086
Anaphylactoid reaction	32.15	28.14	17	16204	6809	110566269
Device issue	32.07	28.14	32	16189	34503	110538575
Postoperative respiratory distress	31.97	28.14	5	16216	16	110573062
Vasodilatation	31.89	28.14	14	16207	3730	110569348
Blood bicarbonate decreased	31.81	28.14	16	16205	5781	110567297
Hepatocellular injury	31.49	28.14	38	16183	50604	110522474
Prinzmetal angina	31.36	28.14	12	16209	2257	110570821
Hypertensive crisis	31.18	28.14	27	16194	24345	110548733
Parotid gland enlargement	30.87	28.14	10	16211	1155	110571923
Unresponsive to stimuli	30.46	28.14	42	16179	63748	110509330
Febrile neutropenia	30.37	28.14	5	16216	316762	110256316
Subcutaneous emphysema	29.84	28.14	12	16209	2572	110570506
Acute generalised exanthematous pustulosis	29.76	28.14	25	16196	21639	110551439
Oedema peripheral	29.76	28.14	6	16215	328654	110244424
Coma	29.54	28.14	58	16163	117811	110455267
Atrioventricular block complete	29.31	28.14	24	16197	20058	110553020
Light anaesthesia	29.07	28.14	4	16217	3	110573075
Glossoptosis	28.89	28.14	7	16214	278	110572800
Nystagmus	28.59	28.14	19	16202	11558	110561520
Hyperdynamic left ventricle	28.27	28.14	8	16213	584	110572494

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01AB08	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Halogenated hydrocarbons
MeSH PA	D000777	Anesthetics
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006401	Hematologic Agents
MeSH PA	D010975	Platelet Aggregation Inhibitors
MeSH PA	D018685	Anesthetics, Inhalation
FDA EPC	N0000175681	General Anesthetic
FDA PE	N0000175975	General Anesthesia
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35488	central nervous system depressant
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:38870	inhalation anaesthetic
CHEBI has role	CHEBI:50247	antidote
CHEBI has role	CHEBI:50427	platelet aggregation inhibitor
CHEBI has role	CHEBI:63726	neuroprotective agent
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:74518	anti-obesity agent
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

N01AB Halogenated hydrocarbons 6 drugs

chloroformdesfluraneenfluranehalothaneisofluranetrichloroethylene

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Hyperkalemia	contraindication	14140009
Proteinuria	contraindication	29738008	DOID:576
Low blood pressure	contraindication	45007003
Glycosuria	contraindication	45154002
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Duchenne muscular dystrophy	contraindication	76670001	DOID:11723
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Disease of liver	contraindication	235856003	DOID:409
Malignant hyperthermia	contraindication	405501007

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Induction and maintenance of general anesthesia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
SevoFlo	Zoetis Inc.	1
Petrem	Piramal Critical Care Inc.	1
Sevoflurane	Dechra Veterinary Products LLC	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN	POSITIVE MODULATOR				DRUGBANK	CHEMBL
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN	OPENER				CHEMBL	CHEMBL
Potassium channel subfamily K member 3	Ion channel	O14649	KCNK3_HUMAN	OPENER				CHEMBL	CHEMBL
Potassium channel subfamily K member 9	Ion channel	Q9NPC2	KCNK9_HUMAN	OPENER				CHEMBL	CHEMBL
Potassium channel subfamily K member 10	Ion channel	P57789	KCNKA_HUMAN	OPENER				CHEMBL	CHEMBL
Potassium channel subfamily K member 18	Ion channel	Q7Z418	KCNKI_HUMAN	OPENER				CHEMBL	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4020924	VUID
N0000148409	NUI
D00547	KEGG_DRUG
4020924	VANDF
C0074414	UMLSCUI
CHEBI:9130	CHEBI
A1IPI	PDB_CHEM_ID
CHEMBL1200694	ChEMBL_ID
DB01236	DRUGBANK_ID
D000077149	MESH_DESCRIPTOR_UI
5206	PUBCHEM_CID
7296	IUPHAR_LIGAND_ID
3028	INN_ID
38LVP0K73A	UNII
1245040	RXNORM
7414	MMSL
81183	MMSL
d03845	MMSL
005015	NDDF
108395008	SNOMEDCT_US
386842005	SNOMEDCT_US
38LVP0K73A	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	31 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	31 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0527-6123	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	22 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-655	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-657	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	12164-005	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	26 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	42677-308	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	21 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	58181-5200	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	25 sections
Sojourn	HUMAN PRESCRIPTION DRUG LABEL	1	66794-012	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	22 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-015	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-022	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	14 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	72162-2245	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	72162-2245	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane Bostonbio	HUMAN PRESCRIPTION DRUG LABEL	1	72163-005	INHALANT	1 mL	RESPIRATORY (INHALATION)	ANDA	2 sections
Sevoflurane, (Volatile for Inhalation)	HUMAN PRESCRIPTION DRUG LABEL	1	83301-0070	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	30 sections