sevoflurane Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 2439 28523-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sevoflurane
  • sevoflo
  • sevofluran
  • sevofrane
  • sevorane
A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
  • Molecular weight: 200.06
  • Formula: C4H3F7O
  • CLOGP: 1.45
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -2.13
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 7, 1995 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 237.15 90.02 33 908 137 2357007
Hypotension 229.36 90.02 80 861 32356 2324788
Unwanted awareness during anaesthesia 190.52 90.02 24 917 34 2357110
Anaphylactic shock 187.34 90.02 44 897 4242 2352902
Delayed recovery from anaesthesia 185.25 90.02 27 914 165 2356979
Bronchospasm 142.31 90.02 33 908 2991 2354153
Anaesthetic complication 141.11 90.02 24 917 431 2356713
Cardiac arrest 137.03 90.02 45 896 14885 2342259
Oxygen saturation decreased 125.56 90.02 36 905 7550 2349594
Bradycardia 124.31 90.02 38 903 9943 2347201
Blood pressure decreased 122.88 90.02 37 904 9199 2347945
Tachycardia 121.09 90.02 42 899 16367 2340777
Hypercapnia 116.58 90.02 21 920 531 2356613
Hepatorenal failure 106.95 90.02 16 925 119 2357025
Suspected product quality issue 104.62 90.02 13 928 15 2357129
Blood lactic acid increased 95.35 90.02 19 922 832 2356312
Lung hyperinflation 92.88 90.02 14 927 110 2357034
Torsade de pointes 92.38 90.02 22 919 2224 2354920

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 685.54 75.33 96 832 233 1745620
Cardiac arrest 263.41 75.33 84 844 15846 1730007
Hypotension 198.27 75.33 80 848 29574 1716279
Anaesthetic complication 184.39 75.33 30 898 238 1745615
Bradycardia 175.20 75.33 56 872 10478 1735375
Ventricular fibrillation 174.87 75.33 42 886 2714 1743139
Tachycardia 141.80 75.33 50 878 12578 1733275
Ventricular tachycardia 137.51 75.33 37 891 3761 1742092
Oxygen saturation decreased 114.22 75.33 35 893 5640 1740213
Rhabdomyolysis 105.86 75.33 39 889 11051 1734802
Delayed recovery from anaesthesia 98.32 75.33 16 912 126 1745727
Anaphylactic reaction 95.13 75.33 31 897 6082 1739771
Blood pressure decreased 92.19 75.33 32 896 7614 1738239
Hypoxic-ischaemic encephalopathy 85.20 75.33 19 909 873 1744980
Post procedural complication 80.44 75.33 22 906 2358 1743495
Hepatorenal failure 75.38 75.33 13 915 150 1745703

Pharmacologic Action:

SourceCodeDescription
ATC N01AB08 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:35488 central nervous system depressant
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Proteinuria contraindication 29738008 DOID:576
Low blood pressure contraindication 45007003
Glycosuria contraindication 45154002
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR DRUGBANK CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL

External reference:

IDSource
D000077149 MESH_DESCRIPTOR_UI
4020924 VUID
N0000148409 NUI
C0074414 UMLSCUI
D00547 KEGG_DRUG
38LVP0K73A UNII
3028 INN_ID
108395008 SNOMEDCT_US
4020924 VANDF
81183 MMSL
386842005 SNOMEDCT_US
d03845 MMSL
7414 MMSL
36453 RXNORM
005015 NDDF
5206 PUBCHEM_CID
CHEBI:9130 CHEBI
CHEMBL1200694 ChEMBL_ID
DB01236 DRUGBANK_ID
7296 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 12 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-005 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane Bostonbio HUMAN PRESCRIPTION DRUG LABEL 1 72163-005 INHALANT 1 mL RESPIRATORY (INHALATION) ANDA 2 sections