sevoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 2439 28523-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sevoflurane
  • sevoflo
  • sevofluran
  • sevofrane
  • sevorane
A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
  • Molecular weight: 200.06
  • Formula: C4H3F7O
  • CLOGP: 1.83
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -2.13
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 40
kinase-selectivity-class AXL,GRK2,PDK1,PDK2,PIK3CD,PIK3CG 6
pfas-class PFAS structural alert (1 = True, 0 = False) 1

Approvals:

DateAgencyCompanyOrphan
June 7, 1995 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Delayed recovery from anaesthesia 495.48 35.71 86 8727 944 90618690
Hypotension 376.76 35.71 285 8528 325112 90294522
Serotonin syndrome 355.83 35.71 135 8678 37752 90581882
Drug interaction 317.10 35.71 241 8572 276212 90343422
Hyperthermia malignant 316.35 35.71 61 8752 1237 90618397
Anaphylactic shock 308.93 35.71 116 8697 31501 90588133
Myoglobin urine present 302.17 35.71 54 8759 708 90618926
Bronchospasm 262.08 35.71 92 8721 20617 90599017
Cardiac arrest 224.73 35.71 135 8678 104800 90514834
Unwanted awareness during anaesthesia 209.12 35.71 36 8777 374 90619260
Bradycardia 200.81 35.71 116 8697 83731 90535903
Amylase increased 186.85 35.71 55 8758 7017 90612617
Anaesthetic complication 185.70 35.71 44 8769 2421 90617213
Toxic encephalopathy 184.02 35.71 57 8756 8642 90610992
Anaesthetic complication neurological 169.32 35.71 33 8780 708 90618926
Apnoea 147.08 35.71 49 8764 9365 90610269
Troponin increased 145.31 35.71 53 8760 13228 90606406
Tachycardia 132.62 35.71 115 8698 157558 90462076
Blood creatine phosphokinase increased 129.11 35.71 64 8749 33959 90585675
Blood potassium increased 128.97 35.71 55 8758 20694 90598940
Phrenic nerve paralysis 126.93 35.71 23 8790 327 90619307
Tracheal deviation 125.65 35.71 22 8791 254 90619380
Blood lactate dehydrogenase increased 123.42 35.71 57 8756 25875 90593759
Oxygen saturation decreased 123.32 35.71 94 8719 107389 90512245
Hypercapnia 121.46 35.71 39 8774 6638 90612996
Ventricular tachycardia 119.75 35.71 55 8758 24653 90594981
Haemodynamic instability 117.93 35.71 44 8769 11695 90607939
Neuromuscular block prolonged 112.65 35.71 23 8790 629 90619005
Stress cardiomyopathy 112.41 35.71 44 8769 13311 90606323
Blood pressure decreased 112.15 35.71 77 8736 74818 90544816
Ventricular fibrillation 110.26 35.71 44 8769 14000 90605634
Diabetes insipidus 107.31 35.71 30 8783 3182 90616452
Rhabdomyolysis 107.12 35.71 65 8748 51191 90568443
Torsade de pointes 106.94 35.71 44 8769 15138 90604496
Dystonia 102.60 35.71 44 8769 16775 90602859
Anaphylactic reaction 99.16 35.71 76 8737 87448 90532186
Respiratory depression 89.28 35.71 39 8774 15536 90604098
Post procedural complication 87.94 35.71 41 8772 19001 90600633
Breast cancer recurrent 87.37 35.71 29 8784 5474 90614160
Airway peak pressure increased 79.66 35.71 16 8797 402 90619232
Alanine aminotransferase increased 77.32 35.71 75 8738 118263 90501371
Laryngospasm 75.38 35.71 23 8790 3310 90616324
Maternal exposure during delivery 72.14 35.71 23 8790 3823 90615811
Recurrence of neuromuscular blockade 71.59 35.71 13 8800 187 90619447
Hypoxia 71.50 35.71 58 8755 72341 90547293
Respiratory acidosis 69.20 35.71 27 8786 8092 90611542
Procedural hypotension 67.69 35.71 18 8795 1582 90618052
Fatigue 67.58 35.71 15 8798 1154008 89465626
Hepatorenal failure 66.07 35.71 15 8798 682 90618952
Cardio-respiratory arrest 65.35 35.71 52 8761 63088 90556546
Circulatory collapse 63.65 35.71 36 8777 24868 90594766
Cyanosis 63.29 35.71 33 8780 19422 90600212
Mydriasis 62.19 35.71 30 8783 14982 90604652
Suspected product quality issue 61.60 35.71 13 8800 419 90619215
Blood lactic acid increased 60.32 35.71 25 8788 8753 90610881
Premature delivery 58.32 35.71 40 8773 38722 90580912
Postoperative delirium 57.90 35.71 11 8802 205 90619429
Neuromuscular blockade 57.89 35.71 12 8801 354 90619280
Agitation postoperative 57.82 35.71 8 8805 14 90619620
Vasoplegia syndrome 57.65 35.71 18 8795 2796 90616838
PCO2 increased 56.63 35.71 15 8798 1298 90618336
Lung hyperinflation 55.60 35.71 15 8798 1393 90618241
Blood pH decreased 55.08 35.71 17 8796 2541 90617093
Carcinoid crisis 54.37 35.71 11 8802 287 90619347
Hypoventilation 53.72 35.71 20 8793 5276 90614358
Diarrhoea 51.42 35.71 14 8799 939176 89680458
Paralysis 50.78 35.71 24 8789 11454 90608180
Therapeutic product effect prolonged 50.76 35.71 11 8802 403 90619231
Acute generalised exanthematous pustulosis 49.66 35.71 25 8788 13678 90605956
PO2 decreased 49.33 35.71 14 8799 1567 90618067
Procedural complication 48.16 35.71 19 8794 5859 90613775
Procedural hypertension 47.22 35.71 10 8803 328 90619306
Status asthmaticus 47.16 35.71 12 8801 887 90618747
Sinus tachycardia 46.66 35.71 31 8782 28482 90591152
Myotonia 46.49 35.71 9 8804 186 90619448
Hepatocellular injury 46.22 35.71 31 8782 28927 90590707
Coma 45.48 35.71 45 8768 72587 90547047
Anuria 44.98 35.71 24 8789 14794 90604840
Exposure during pregnancy 44.97 35.71 82 8731 238328 90381306
Epilepsy with myoclonic-atonic seizures 44.74 35.71 8 8805 105 90619529
Blood bicarbonate decreased 43.83 35.71 15 8798 3104 90616530
Electrocardiogram QT prolonged 43.72 35.71 44 8769 72412 90547222
Pulmonary oedema 43.65 35.71 41 8772 62039 90557595
End-tidal CO2 decreased 41.46 35.71 7 8806 64 90619570
Airway complication of anaesthesia 39.27 35.71 9 8804 427 90619207
Endotracheal intubation complication 38.97 35.71 9 8804 442 90619192
Ventricular extrasystoles 38.92 35.71 21 8792 13229 90606405
Pain 38.32 35.71 25 8788 996316 89623318
End-tidal CO2 increased 36.82 35.71 5 8808 7 90619627
Acute postoperative sialadenitis 36.60 35.71 6 8807 45 90619589
Posterior reversible encephalopathy syndrome 35.85 35.71 24 8789 22315 90597319
Pneumonia 35.83 35.71 9 8804 638050 89981584
Dizziness 35.73 35.71 7 8806 589277 90030357

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 909.68 30.81 186 8176 2472 42610501
Delayed recovery from anaesthesia 330.99 30.81 70 8292 1099 42611874
Cardiac arrest 292.71 30.81 210 8152 109110 42503863
Anaphylactic shock 282.99 30.81 122 8240 23395 42589578
Anaphylactic reaction 243.91 30.81 133 8229 42610 42570363
Bradycardia 225.74 30.81 163 8199 85321 42527652
Anaesthetic complication 224.25 30.81 53 8309 1404 42611569
Hypotension 194.54 30.81 245 8117 257386 42355587
Apnoea 161.85 30.81 60 8302 7743 42605230
Post procedural complication 143.74 30.81 63 8299 12527 42600446
Serotonin syndrome 140.58 30.81 78 8284 25767 42587206
Tachycardia 136.89 30.81 131 8231 100956 42512017
Pulmonary alveolar haemorrhage 130.84 30.81 62 8300 14754 42598219
Anaesthetic complication neurological 130.29 30.81 30 8332 706 42612267
Bronchospasm 123.30 30.81 57 8305 12828 42600145
Ventricular fibrillation 121.76 30.81 75 8287 30048 42582925
Oxygen saturation decreased 121.66 30.81 101 8261 64586 42548387
Nephrogenic diabetes insipidus 121.53 30.81 33 8329 1541 42611432
Negative pressure pulmonary oedema 118.82 30.81 27 8335 598 42612375
Ventricular tachycardia 109.11 30.81 70 8292 30090 42582883
Neuromuscular block prolonged 108.34 30.81 25 8337 594 42612379
Recurrence of neuromuscular blockade 104.10 30.81 21 8341 257 42612716
Blood pressure decreased 97.21 30.81 85 8277 58247 42554726
Diabetes insipidus 89.83 30.81 32 8330 3681 42609292
Laryngospasm 87.84 30.81 27 8335 1961 42611012
Drug interaction 83.35 30.81 170 8192 266829 42346144
Stress cardiomyopathy 82.82 30.81 28 8334 2757 42610216
Procedural complication 78.59 30.81 30 8332 4189 42608784
Electrocardiogram ST segment elevation 78.57 30.81 33 8329 5906 42607067
Metabolic acidosis 75.39 30.81 70 8292 51788 42561185
Unwanted awareness during anaesthesia 73.09 30.81 12 8350 39 42612934
Rhabdomyolysis 72.90 30.81 83 8279 77936 42535037
Hypoxic-ischaemic encephalopathy 72.50 30.81 30 8332 5172 42607801
Tachypnoea 70.31 30.81 47 8315 21615 42591358
Hyperkalaemia 65.87 30.81 80 8282 80378 42532595
End-tidal CO2 increased 62.57 30.81 10 8352 26 42612947
Pulmonary oedema 60.79 30.81 63 8299 53209 42559764
Electrocardiogram ST segment depression 60.25 30.81 22 8340 2715 42610258
Haemodynamic instability 57.76 30.81 34 8328 12523 42600450
Respiratory acidosis 54.35 30.81 26 8336 6305 42606668
Diarrhoea 52.56 30.81 13 8349 460836 42152137
Death 52.39 30.81 14 8348 471171 42141802
Kounis syndrome 52.32 30.81 21 8341 3347 42609626
Pneumonia 47.94 30.81 12 8350 422137 42190836
Anaesthetic complication pulmonary 47.43 30.81 9 8353 78 42612895
Torsade de pointes 46.85 30.81 26 8336 8568 42604405
Sinus arrest 46.23 30.81 17 8345 2139 42610834
Ventricular extrasystoles 45.73 30.81 30 8332 13360 42599613
Blood pressure measurement 45.45 30.81 10 8352 190 42612783
Hyperthermia 44.97 30.81 29 8333 12545 42600428
Extrasystoles 44.59 30.81 20 8342 4189 42608784
Pulseless electrical activity 44.56 30.81 25 8337 8412 42604561
Oculocardiac reflex 44.18 30.81 9 8353 116 42612857
Heart rate increased 43.62 30.81 53 8309 53202 42559771
Hepatorenal failure 42.98 30.81 12 8350 621 42612352
Hypercapnia 42.95 30.81 21 8341 5340 42607633
Spinal cord infarction 42.38 30.81 12 8350 654 42612319
Arteriospasm coronary 42.33 30.81 20 8342 4718 42608255
Procedural haemorrhage 41.68 30.81 17 8345 2824 42610149
Agitation postoperative 41.30 30.81 7 8355 29 42612944
Muscle rigidity 41.14 30.81 27 8335 12032 42600941
Electroencephalogram abnormal 40.82 30.81 17 8345 2975 42609998
Respiratory depression 40.77 30.81 32 8330 18836 42594137
Seizure like phenomena 40.54 30.81 13 8349 1084 42611889
Sodium retention 39.50 30.81 8 8354 100 42612873
Postoperative delirium 39.04 30.81 11 8351 589 42612384
PCO2 increased 37.28 30.81 11 8351 694 42612279
Paroxysmal sympathetic hyperactivity 36.86 30.81 7 8355 61 42612912
Erythema 35.83 30.81 71 8291 108722 42504251
Glossoptosis 34.95 30.81 8 8354 183 42612790
Renin increased 34.20 30.81 8 8354 202 42612771
Prinzmetal angina 33.97 30.81 12 8350 1345 42611628
Hypoventilation 33.81 30.81 16 8346 3786 42609187
Suspected product quality issue 32.81 30.81 8 8354 242 42612731
Dyskinesia 32.55 30.81 32 8330 25358 42587615
Shock 32.40 30.81 34 8328 29087 42583886
Nodal rhythm 31.92 30.81 12 8350 1605 42611368
Atrioventricular block 31.52 30.81 21 8341 9594 42603379
Trismus 31.50 30.81 14 8348 2870 42610103
Pulse absent 31.39 30.81 18 8344 6309 42606664
Acidosis 31.33 30.81 23 8339 12256 42600717
Weight bearing difficulty 31.11 30.81 11 8351 1237 42611736
Carbon dioxide increased 30.90 30.81 11 8351 1261 42611712

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 1115.44 28.14 224 15997 3676 110569402
Anaphylactic shock 571.44 28.14 232 15989 51314 110521764
Anaesthetic complication 559.16 28.14 125 16096 3481 110569597
Hypotension 516.99 28.14 499 15722 523350 110049728
Cardiac arrest 505.78 28.14 330 15891 196423 110376655
Delayed recovery from anaesthesia 485.07 28.14 102 16119 2113 110570965
Serotonin syndrome 431.06 28.14 198 16023 58955 110514123
Bradycardia 375.38 28.14 251 15970 155266 110417812
Bronchospasm 362.19 28.14 144 16077 30095 110542983
Drug interaction 343.14 28.14 393 15828 499790 110073288
Anaphylactic reaction 333.69 28.14 208 16013 114092 110458986
Myoglobin urine present 263.80 28.14 53 16168 867 110572211
Tachycardia 239.64 28.14 225 15996 226420 110346658
Ventricular fibrillation 238.79 28.14 118 16103 41195 110531883
Oxygen saturation decreased 232.75 28.14 189 16032 156793 110416285
Ventricular tachycardia 223.10 28.14 120 16101 49889 110523189
Neuromuscular block prolonged 197.49 28.14 44 16177 1203 110571875
Blood pressure decreased 186.38 28.14 146 16075 114945 110458133
Diabetes insipidus 180.72 28.14 58 16163 6512 110566566
Stress cardiomyopathy 170.99 28.14 70 16151 15736 110557342
Unwanted awareness during anaesthesia 169.03 28.14 32 16189 377 110572701
Pulmonary alveolar haemorrhage 161.00 28.14 72 16149 20078 110553000
Apnoea 159.91 28.14 64 16157 13575 110559503
Negative pressure pulmonary oedema 157.68 28.14 33 16188 666 110572412
Laryngospasm 156.75 28.14 48 16173 4620 110568458
Rhabdomyolysis 151.58 28.14 132 16089 120269 110452809
Haemodynamic instability 149.16 28.14 71 16150 22817 110550261
Anaesthetic complication neurological 144.84 28.14 33 16188 1000 110572078
Torsade de pointes 140.88 28.14 68 16153 22532 110550546
Hypercapnia 140.03 28.14 55 16166 11104 110561974
Respiratory depression 134.92 28.14 74 16147 31927 110541151
Amylase increased 133.90 28.14 55 16166 12464 110560614
Recurrence of neuromuscular blockade 130.59 28.14 26 16195 405 110572673
Nephrogenic diabetes insipidus 130.32 28.14 36 16185 2409 110570669
Fatigue 124.59 28.14 16 16205 1215942 109357136
Dystonia 123.72 28.14 65 16156 25740 110547338
Toxic encephalopathy 123.57 28.14 55 16166 15159 110557919
Procedural complication 118.17 28.14 45 16176 8360 110564718
Respiratory acidosis 115.57 28.14 51 16170 13775 110559303
Tracheal deviation 114.93 28.14 22 16199 276 110572802
Blood creatine phosphokinase increased 112.42 28.14 90 16131 72987 110500091
Phrenic nerve paralysis 111.23 28.14 24 16197 563 110572515
Airway peak pressure increased 108.98 28.14 24 16197 621 110572457
Hepatorenal failure 105.73 28.14 27 16194 1333 110571745
Blood potassium increased 100.62 28.14 62 16159 33187 110539891
Pulmonary oedema 100.58 28.14 97 16124 100562 110472516
Post procedural complication 99.73 28.14 57 16164 26601 110546477
End-tidal CO2 increased 98.21 28.14 15 16206 39 110573039
Arthralgia 97.32 28.14 4 16217 779628 109793450
Diarrhoea 95.27 28.14 25 16196 1139480 109433598
Hypoxia 93.74 28.14 105 16116 129410 110443668
Neuromuscular blockade 89.58 28.14 21 16200 723 110572355
Procedural hypotension 89.41 28.14 27 16194 2478 110570600
Troponin increased 88.79 28.14 55 16166 29711 110543367
Suspected product quality issue 88.66 28.14 20 16201 579 110572499
Postoperative delirium 85.26 28.14 21 16200 894 110572184
Ventricular extrasystoles 83.59 28.14 48 16173 22593 110550485
Hypoxic-ischaemic encephalopathy 81.65 28.14 35 16186 8812 110564266
Metabolic acidosis 81.12 28.14 86 16135 99658 110473420
Cardio-respiratory arrest 80.56 28.14 92 16129 115744 110457334
Electrocardiogram ST segment elevation 80.48 28.14 35 16186 9125 110563953
Extrasystoles 80.39 28.14 34 16187 8284 110564794
Cyanosis 78.83 28.14 51 16170 29690 110543388
Blood lactate dehydrogenase increased 77.70 28.14 59 16162 44275 110528803
Circulatory collapse 77.09 28.14 58 16163 42935 110530143
Hypoventilation 74.68 28.14 32 16189 8049 110565029
Pneumonia 73.64 28.14 19 16202 876695 109696383
PCO2 increased 73.54 28.14 22 16199 1955 110571123
Vasoplegia syndrome 72.45 28.14 28 16193 5411 110567667
Muscle rigidity 68.13 28.14 43 16178 23988 110549090
Tachypnoea 68.10 28.14 52 16169 39343 110533735
Hyperkalaemia 67.32 28.14 91 16130 135705 110437373
Kounis syndrome 66.67 28.14 27 16194 5898 110567180
Fall 66.58 28.14 6 16215 603476 109969602
Carcinoid crisis 63.33 28.14 15 16206 540 110572538
Endotracheal intubation complication 61.64 28.14 16 16205 843 110572235
Arteriospasm coronary 61.64 28.14 29 16192 9071 110564007
Maternal exposure during delivery 60.80 28.14 22 16199 3543 110569535
Airway complication of anaesthesia 60.22 28.14 15 16206 669 110572409
Hyperthermia 60.15 28.14 38 16183 21234 110551844
Alanine aminotransferase increased 59.54 28.14 101 16120 183672 110389406
Procedural hypertension 59.04 28.14 13 16208 336 110572742
Mydriasis 58.73 28.14 38 16183 22119 110550959
Weight decreased 56.40 28.14 3 16218 468054 110105024
Suspected product contamination 56.30 28.14 12 16209 265 110572813
Pulseless electrical activity 55.20 28.14 33 16188 16724 110556354
Procedural haemorrhage 55.18 28.14 23 16198 5404 110567674
Electrocardiogram ST segment depression 55.04 28.14 23 16198 5438 110567640
Paralysis 54.73 28.14 32 16189 15568 110557510
Headache 53.00 28.14 32 16189 882345 109690733
Pain 52.82 28.14 38 16183 954917 109618161
Agitation postoperative 52.13 28.14 9 16212 60 110573018
Cardiac output decreased 51.75 28.14 17 16204 2052 110571026
Death 51.70 28.14 19 16202 698850 109874228
Blood pH decreased 51.58 28.14 21 16200 4648 110568430
Pulse absent 50.04 28.14 27 16194 11265 110561813
Anaesthetic complication pulmonary 49.51 28.14 10 16211 168 110572910
Decreased appetite 49.20 28.14 6 16215 475840 110097238
Acidosis 48.59 28.14 34 16187 22497 110550581
PO2 decreased 48.41 28.14 18 16203 3130 110569948
Dizziness 48.34 28.14 21 16200 698172 109874906
Pain in extremity 48.32 28.14 7 16214 487111 110085967
Drug intolerance 47.76 28.14 3 16218 406509 110166569
Generalised tonic-clonic seizure 47.75 28.14 49 16172 54631 110518447
Peripheral swelling 47.41 28.14 3 16218 404031 110169047
Sinus arrest 46.59 28.14 19 16202 4223 110568855
Blood lactic acid increased 46.58 28.14 29 16192 15792 110557286
Sinus tachycardia 46.54 28.14 44 16177 44449 110528629
Oculocardiac reflex 46.37 28.14 9 16212 122 110572956
Electroencephalogram abnormal 45.94 28.14 21 16200 6152 110566926
Erythema 45.76 28.14 119 16102 291328 110281750
Status asthmaticus 45.18 28.14 13 16208 1008 110572070
Shock 44.96 28.14 47 16174 53541 110519537
Therapeutic product effect prolonged 44.94 28.14 12 16209 706 110572372
Spinal cord infarction 44.25 28.14 13 16208 1085 110571993
Malaise 43.74 28.14 22 16199 671797 109901281
Polyuria 43.55 28.14 29 16192 17709 110555369
Hypernatraemia 43.40 28.14 29 16192 17804 110555274
Atrioventricular block second degree 43.21 28.14 22 16199 8159 110564919
Lung hyperinflation 42.72 28.14 15 16206 2214 110570864
Heart rate increased 42.59 28.14 76 16145 143758 110429320
Anuria 41.77 28.14 32 16189 24309 110548769
Anaesthetic complication cardiac 41.74 28.14 8 16213 101 110572977
Epilepsy with myoclonic-atonic seizures 41.24 28.14 8 16213 108 110572970
Compartment syndrome 40.54 28.14 19 16202 5891 110567187
Respiratory failure 40.22 28.14 94 16127 215238 110357840
Atrioventricular block 40.01 28.14 27 16194 16850 110556228
Myotonia 39.62 28.14 9 16212 269 110572809
Dyskinesia 39.41 28.14 43 16178 51403 110521675
Accelerated idioventricular rhythm 39.18 28.14 9 16212 283 110572795
Blood pressure measurement 38.65 28.14 10 16211 520 110572558
Abdominal pain 37.82 28.14 14 16207 512975 110060103
Seizure like phenomena 37.69 28.14 14 16207 2427 110570651
Acute postoperative sialadenitis 37.49 28.14 7 16214 76 110573002
Acute pulmonary oedema 37.47 28.14 26 16195 16970 110556108
Swelling 37.34 28.14 4 16217 351037 110222041
Infection 36.38 28.14 5 16216 362195 110210883
End-tidal CO2 decreased 36.33 28.14 7 16214 91 110572987
Trismus 35.60 28.14 18 16203 6578 110566500
Post procedural stroke 35.22 28.14 7 16214 108 110572970
Trigemino-cardiac reflex 34.90 28.14 9 16212 462 110572616
Long QT syndrome 34.30 28.14 18 16203 7100 110565978
Upper airway obstruction 34.06 28.14 12 16209 1790 110571288
Neutropenia 33.60 28.14 7 16214 374613 110198465
Chemical peritonitis 33.54 28.14 8 16213 297 110572781
Product dose omission issue 33.38 28.14 4 16217 321778 110251300
Electrocardiogram QT prolonged 32.80 28.14 58 16163 108902 110464176
Agitation 32.52 28.14 59 16162 112992 110460086
Anaphylactoid reaction 32.15 28.14 17 16204 6809 110566269
Device issue 32.07 28.14 32 16189 34503 110538575
Postoperative respiratory distress 31.97 28.14 5 16216 16 110573062
Vasodilatation 31.89 28.14 14 16207 3730 110569348
Blood bicarbonate decreased 31.81 28.14 16 16205 5781 110567297
Hepatocellular injury 31.49 28.14 38 16183 50604 110522474
Prinzmetal angina 31.36 28.14 12 16209 2257 110570821
Hypertensive crisis 31.18 28.14 27 16194 24345 110548733
Parotid gland enlargement 30.87 28.14 10 16211 1155 110571923
Unresponsive to stimuli 30.46 28.14 42 16179 63748 110509330
Febrile neutropenia 30.37 28.14 5 16216 316762 110256316
Subcutaneous emphysema 29.84 28.14 12 16209 2572 110570506
Acute generalised exanthematous pustulosis 29.76 28.14 25 16196 21639 110551439
Oedema peripheral 29.76 28.14 6 16215 328654 110244424
Coma 29.54 28.14 58 16163 117811 110455267
Atrioventricular block complete 29.31 28.14 24 16197 20058 110553020
Light anaesthesia 29.07 28.14 4 16217 3 110573075
Glossoptosis 28.89 28.14 7 16214 278 110572800
Nystagmus 28.59 28.14 19 16202 11558 110561520
Hyperdynamic left ventricle 28.27 28.14 8 16213 584 110572494

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB08 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018685 Anesthetics, Inhalation
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35488 central nervous system depressant
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38870 inhalation anaesthetic
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

N01AB Halogenated hydrocarbons 6 drugs
chloroformdesfluraneenfluranehalothaneisofluranetrichloroethylene

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Proteinuria contraindication 29738008 DOID:576
Low blood pressure contraindication 45007003
Glycosuria contraindication 45154002
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Induction and maintenance of general anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
SevoFlo Zoetis Inc. 1
Petrem Piramal Critical Care Inc. 1
Sevoflurane Dechra Veterinary Products LLC 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR DRUGBANK CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4020924 VUID
N0000148409 NUI
D00547 KEGG_DRUG
4020924 VANDF
C0074414 UMLSCUI
CHEBI:9130 CHEBI
A1IPI PDB_CHEM_ID
CHEMBL1200694 ChEMBL_ID
DB01236 DRUGBANK_ID
D000077149 MESH_DESCRIPTOR_UI
5206 PUBCHEM_CID
7296 IUPHAR_LIGAND_ID
3028 INN_ID
38LVP0K73A UNII
1245040 RXNORM
7414 MMSL
81183 MMSL
d03845 MMSL
005015 NDDF
108395008 SNOMEDCT_US
386842005 SNOMEDCT_US
38LVP0K73A INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 31 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 31 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0527-6123 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 22 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 20 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-655 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-657 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-005 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 26 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 42677-308 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 21 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 58181-5200 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 25 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 22 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-022 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 14 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 72162-2245 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 72162-2245 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane Bostonbio HUMAN PRESCRIPTION DRUG LABEL 1 72163-005 INHALANT 1 mL RESPIRATORY (INHALATION) ANDA 2 sections
Sevoflurane, (Volatile for Inhalation) HUMAN PRESCRIPTION DRUG LABEL 1 83301-0070 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 30 sections