retinol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2372 127-47-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • retinyl acetate
  • QLT091001
  • retinol acetate
  • Vitamin A acetate
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.35
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -5.14
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1647.86 9.77 3081 370621 117085 50114337
Systemic lupus erythematosus 1536.43 9.77 3279 370423 137343 50094079
Glossodynia 1322.47 9.77 2747 370955 112822 50118600
Rheumatoid arthritis 1074.22 9.77 3612 370090 198938 50032484
Hand deformity 1053.91 9.77 2302 371400 97897 50133525
Arthropathy 949.11 9.77 2940 370762 154966 50076456
Maternal exposure during pregnancy 947.56 9.77 2961 370741 156817 50074605
Alopecia 927.27 9.77 3922 369780 241125 49990297
Abdominal discomfort 907.26 9.77 3747 369955 227894 50003528
Wound 860.61 9.77 2199 371503 103595 50127827
Completed suicide 742.31 9.77 62 373640 131827 50099595
Infusion related reaction 687.82 9.77 2774 370928 166783 50064639
Synovitis 685.98 9.77 2243 371459 121622 50109800
Pericarditis 656.69 9.77 1652 372050 77037 50154385
Anti-cyclic citrullinated peptide antibody positive 645.49 9.77 1535 372167 69052 50162370
Contraindicated product administered 631.33 9.77 2471 371231 146487 50084935
Discomfort 615.71 9.77 1980 371722 106400 50125022
Swelling 594.40 9.77 2993 370709 197879 50033543
Joint swelling 577.46 9.77 3434 370268 241852 49989570
Pain 569.04 9.77 6646 367056 572257 49659165
Toxicity to various agents 543.96 9.77 462 373240 212037 50019385
Death 448.78 9.77 1096 372606 324283 49907139
Product use issue 402.16 9.77 2170 371532 147305 50084117
Rheumatoid factor positive 395.26 9.77 1027 372675 48832 50182590
Duodenal ulcer perforation 372.39 9.77 950 372752 44661 50186761
Arthralgia 370.42 9.77 4899 368803 433803 49797619
Helicobacter infection 360.88 9.77 991 372711 48711 50182711
Drug interaction 331.34 9.77 605 373097 199016 50032406
Hepatic enzyme increased 330.73 9.77 1936 371766 135444 50095978
Drug abuse 315.89 9.77 36 373666 59810 50171612
Intentional overdose 307.43 9.77 47 373655 62457 50168965
Exposure during pregnancy 286.45 9.77 1698 372004 119317 50112105
Drug intolerance 251.57 9.77 2598 371104 216506 50014916
Hip arthroplasty 249.59 9.77 635 373067 29794 50201628
Musculoskeletal stiffness 248.64 9.77 1713 371989 126768 50104654
Therapeutic product effect decreased 240.11 9.77 1774 371928 134276 50097146
Treatment failure 234.60 9.77 1780 371922 135857 50095565
Knee arthroplasty 230.28 9.77 684 373018 35162 50196260
Febrile neutropenia 216.37 9.77 241 373461 97426 50133996
Overdose 207.10 9.77 259 373443 99468 50131954
Psoriatic arthropathy 195.40 9.77 776 372926 46256 50185166
Suicide attempt 195.07 9.77 69 373633 51663 50179759
Nasopharyngitis 194.25 9.77 2229 371473 190698 50040724
Acute kidney injury 190.37 9.77 951 372751 227107 50004315
Cardiac arrest 185.74 9.77 206 373496 83445 50147977
Depressed level of consciousness 178.36 9.77 80 373622 51873 50179549
Red blood cell sedimentation rate abnormal 169.79 9.77 374 373328 15969 50215453
Hypersensitivity 164.96 9.77 2364 371338 212797 50018625
Malignant neoplasm progression 161.09 9.77 159 373543 67965 50163457
Diarrhoea 156.34 9.77 3239 370463 585237 49646185
C-reactive protein abnormal 154.88 9.77 505 373197 27304 50204118
Disease progression 150.59 9.77 300 373402 95566 50135856
Drug hypersensitivity 148.68 9.77 1164 372538 249846 49981576
Impaired healing 148.48 9.77 953 372749 68833 50162589
Constipation 146.68 9.77 789 372913 184919 50046503
Device expulsion 145.59 9.77 20 373682 28802 50202620
Nausea 142.60 9.77 4046 369656 701352 49530070
Rheumatic fever 142.49 9.77 356 373346 16511 50214911
Drug ineffective 140.85 9.77 7390 366312 811943 49419479
Swollen joint count increased 137.48 9.77 325 373377 14548 50216874
Sickle cell anaemia with crisis 133.01 9.77 166 373536 4377 50227045
Bradycardia 131.97 9.77 169 373533 64257 50167165
Lactic acidosis 130.08 9.77 42 373660 33313 50198109
Neutropenia 127.99 9.77 609 373093 147356 50084066
Sedation 125.81 9.77 35 373667 30575 50200847
Cardiac failure 125.49 9.77 231 373471 75809 50155613
Hyponatraemia 122.04 9.77 337 373365 95802 50135620
Asthenia 121.49 9.77 1643 372059 317399 49914023
Anxiety 118.92 9.77 795 372907 176811 50054611
Tremor 118.48 9.77 442 373260 114461 50116961
Electrocardiogram QT prolonged 116.01 9.77 127 373575 51759 50179663
Hypotension 113.01 9.77 1152 372550 234317 49997105
Pregnancy 110.99 9.77 473 373229 29104 50202318
Somnolence 110.77 9.77 680 373022 154305 50077117
Dizziness 107.53 9.77 1855 371847 344514 49886908
Dyspnoea 106.58 9.77 3156 370546 544452 49686970
Rash 106.10 9.77 4089 369613 433382 49798040
Fatigue 105.95 9.77 6304 367398 701297 49530125
Respiratory arrest 104.91 9.77 45 373657 29964 50201458
Sleep disorder due to general medical condition, insomnia type 103.75 9.77 484 373218 30963 50200459
Agitation 103.28 9.77 146 373556 53238 50178184
Vomiting 103.17 9.77 2603 371099 458155 49773267
Muscle injury 101.76 9.77 542 373160 36569 50194853
Renal failure 101.14 9.77 424 373278 106209 50125213
Folliculitis 100.91 9.77 563 373139 38662 50192760
Psoriasis 100.90 9.77 862 372840 68138 50163284
Arthritis 98.65 9.77 1027 372675 85694 50145728
Live birth 97.77 9.77 305 373397 16103 50215319
Multiple sclerosis relapse 97.34 9.77 104 373598 42860 50188562
Abortion spontaneous 96.05 9.77 582 373120 41190 50190232
Lower respiratory tract infection 95.68 9.77 1100 372602 94101 50137321
Drug reaction with eosinophilia and systemic symptoms 92.60 9.77 47 373655 28377 50203045
Rhabdomyolysis 92.35 9.77 91 373611 38936 50192486
Blister 91.76 9.77 1000 372702 84418 50147004
Sopor 88.97 9.77 19 373683 19860 50211562
Intentional self-injury 88.54 9.77 30 373672 23082 50208340
Osteoarthritis 86.99 9.77 831 372871 67775 50163647
Hyperhidrosis 85.78 9.77 354 373348 89072 50142350
Neoplasm progression 85.29 9.77 55 373647 29102 50202320
Neuropathy peripheral 84.35 9.77 397 373305 96360 50135062
Condition aggravated 82.47 9.77 2820 370882 294238 49937184
Drug withdrawal syndrome 80.92 9.77 42 373660 25039 50206383
Injection site erythema 80.81 9.77 878 372824 74058 50157364
Insomnia 80.77 9.77 863 372839 174002 50057420
Cardio-respiratory arrest 78.44 9.77 176 373526 53716 50177706
Blood pressure fluctuation 76.65 9.77 490 373212 35333 50196089
Syncope 75.61 9.77 448 373254 102554 50128868
Tachycardia 75.32 9.77 430 373272 99333 50132089
Irritable bowel syndrome 74.85 9.77 642 373060 50799 50180623
Myalgia 74.65 9.77 574 373128 123745 50107677
Product quality issue 74.11 9.77 71 373631 30787 50200635
Drug dependence 73.38 9.77 27 373675 19732 50211690
Serotonin syndrome 73.13 9.77 46 373656 24667 50206755
Hypoglycaemia 72.40 9.77 182 373520 53399 50178023
Renal impairment 71.63 9.77 301 373401 75360 50156062
Joint effusion 71.18 9.77 235 373467 12786 50218636
Hepatic failure 71.08 9.77 80 373622 32203 50199219
Anaemia 71.03 9.77 1375 372327 251081 49980341
Encephalopathy 70.52 9.77 87 373615 33624 50197798
Cognitive disorder 70.18 9.77 137 373565 43986 50187436
Injection site pruritus 70.06 9.77 525 373177 39886 50191536
Hypoxia 68.80 9.77 174 373528 50949 50180473
Coma 68.04 9.77 205 373497 56674 50174748
Palmar-plantar erythrodysaesthesia syndrome 67.34 9.77 32 373670 20066 50211356
Hyperglycaemia 64.22 9.77 106 373596 36299 50195123
Caesarean section 64.09 9.77 257 373445 15382 50216040
Juvenile idiopathic arthritis 64.04 9.77 92 373610 2787 50228635
Disability assessment scale score increased 64.03 9.77 83 373619 2275 50229147
Basal cell carcinoma 63.95 9.77 341 373361 23015 50208407
Sinusitis 63.13 9.77 1678 372024 168880 50062542
Respiratory failure 63.06 9.77 404 373298 90777 50140645
Drug resistance 62.46 9.77 31 373671 18958 50212464
Red blood cell sedimentation rate increased 62.09 9.77 401 373301 29015 50202407
Intentional product misuse 61.40 9.77 161 373541 46573 50184849
Metabolic acidosis 61.36 9.77 121 373581 38704 50192718
No adverse event 60.90 9.77 96 373606 33482 50197940
Asthma 60.68 9.77 398 373304 88939 50142483
Thrombocytopenia 59.78 9.77 628 373074 127045 50104377
Feeling abnormal 59.68 9.77 615 373087 124877 50106545
Hepatic function abnormal 58.73 9.77 94 373608 32587 50198835
Cardiac failure congestive 58.29 9.77 374 373328 84008 50147414
Muscle spasms 58.20 9.77 619 373083 124934 50106488
Foot deformity 57.83 9.77 288 373414 18922 50212500
Urticaria 57.57 9.77 645 373057 128916 50102506
Ill-defined disorder 56.91 9.77 636 373066 54018 50177404
Joint laxity 56.85 9.77 79 373623 2319 50229103
Balance disorder 56.71 9.77 298 373404 70292 50161130
Multiple organ dysfunction syndrome 56.29 9.77 187 373515 50150 50181272
Diabetic ketoacidosis 56.08 9.77 31 373671 17841 50213581
Contusion 55.75 9.77 1150 372552 111033 50120389
Blood glucose increased 55.14 9.77 305 373397 71019 50160403
Fluid retention 54.04 9.77 192 373510 50457 50180965
Blood pressure diastolic abnormal 53.93 9.77 172 373530 9189 50222233
Hallucination 53.79 9.77 171 373531 46486 50184936
Muscle spasticity 53.65 9.77 30 373672 17154 50214268
Injection site swelling 53.44 9.77 507 373195 41266 50190156
Injection site reaction 53.37 9.77 585 373117 49447 50181975
Osteoporosis 53.16 9.77 536 373166 44343 50187079
Peripheral swelling 52.85 9.77 1938 371764 203998 50027424
Cholestasis 52.66 9.77 66 373636 25335 50206087
Sedation complication 52.52 9.77 3 373699 8763 50222659
Blood cholesterol increased 52.35 9.77 631 373071 54584 50176838
Fibromyalgia 52.23 9.77 535 373167 44443 50186979
Injection site pain 52.21 9.77 1129 372573 109895 50121527
Altered state of consciousness 51.93 9.77 51 373651 21859 50209563
Seizure 51.90 9.77 588 373114 117286 50114136
Pulmonary embolism 51.88 9.77 490 373212 101214 50130208
Orthostatic hypotension 51.85 9.77 86 373616 29395 50202027
Respiratory disorder 51.21 9.77 95 373607 31092 50200330
Disturbance in attention 51.20 9.77 95 373607 31091 50200331
Mental status changes 50.73 9.77 121 373581 36151 50195271
Vision blurred 50.61 9.77 356 373346 78291 50153131
Foetal exposure during pregnancy 50.61 9.77 361 373341 26998 50204424
Type 2 diabetes mellitus 50.00 9.77 429 373273 33946 50197476
Dehydration 49.93 9.77 808 372894 151641 50079781
Cytomegalovirus infection 49.71 9.77 36 373666 17926 50213496
Grip strength decreased 49.52 9.77 199 373503 11922 50219500
Chest discomfort 48.90 9.77 443 373259 92279 50139143
Hypokalaemia 48.79 9.77 415 373287 87577 50143845
Bone erosion 48.65 9.77 193 373509 11494 50219928
Loss of personal independence in daily activities 48.60 9.77 757 372945 69293 50162129
Emotional distress 48.23 9.77 86 373616 28577 50202845
Hepatocellular injury 48.18 9.77 73 373629 25874 50205548
Premature labour 48.16 9.77 190 373512 11286 50220136
Mydriasis 47.88 9.77 10 373692 10617 50220805
Metastases to bone 47.33 9.77 38 373664 17957 50213465
Blood pressure systolic increased 47.23 9.77 434 373268 35015 50196407
Neutrophil count decreased 46.79 9.77 178 373524 45848 50185574
Restlessness 46.58 9.77 71 373631 25102 50206320
Ejection fraction decreased 46.38 9.77 41 373661 18479 50212943
Pulmonary arterial hypertension 46.23 9.77 49 373653 20270 50211152
Decreased appetite 45.88 9.77 1131 372571 199792 50031630
Depression 45.85 9.77 903 372799 164520 50066902
Blood pressure systolic abnormal 45.68 9.77 143 373559 7563 50223859
Gestational diabetes 45.62 9.77 140 373562 7325 50224097
Anaphylactic reaction 45.23 9.77 225 373477 53830 50177592
White blood cell count decreased 45.05 9.77 599 373103 116123 50115299
Loss of consciousness 44.59 9.77 524 373178 103829 50127593
Hyperkalaemia 44.47 9.77 193 373509 47896 50183526
Poisoning 44.47 9.77 18 373684 12411 50219011
Dyspnoea exertional 44.17 9.77 211 373491 51022 50180400
Product use in unapproved indication 44.10 9.77 596 373106 115223 50116199
Delirium 44.01 9.77 140 373562 38052 50193370
Infection 43.96 9.77 1626 372076 171328 50060094
Neck deformity 43.69 9.77 63 373639 1915 50229507
Product administration error 43.16 9.77 49 373653 19650 50211772
Hospitalisation 42.99 9.77 309 373393 67628 50163794
Osteonecrosis of jaw 42.77 9.77 112 373590 32414 50199008
Speech disorder 42.60 9.77 128 373574 35420 50196002
Shock 42.45 9.77 54 373648 20596 50210826
Tuberculosis 42.36 9.77 167 373535 9916 50221506
Multiple fractures 42.29 9.77 126 373576 6485 50224937
Weight increased 42.29 9.77 1859 371843 200032 50031390
Hypothermia 42.03 9.77 18 373684 11998 50219424
Respiratory depression 41.99 9.77 18 373684 11992 50219430
Maternal drugs affecting foetus 41.67 9.77 106 373596 4971 50226451
Disorientation 41.64 9.77 129 373573 35355 50196067
Suicidal ideation 41.64 9.77 239 373463 55146 50176276
Rheumatoid nodule 41.26 9.77 195 373507 12540 50218882
Extrapyramidal disorder 40.58 9.77 18 373684 11752 50219670
Leukopenia 40.41 9.77 312 373390 67216 50164206
Memory impairment 40.19 9.77 383 373319 78977 50152445
Acute hepatic failure 40.12 9.77 34 373668 15643 50215779
Myocardial infarction 40.01 9.77 442 373260 88585 50142837
Creatinine renal clearance decreased 39.68 9.77 19 373683 11862 50219560
Blood creatine phosphokinase increased 39.27 9.77 85 373617 26282 50205140
Blood pressure decreased 39.01 9.77 247 373455 55662 50175760
Gamma-glutamyltransferase increased 38.19 9.77 103 373599 29520 50201902
Angioedema 38.10 9.77 146 373556 37530 50193892
Drug level increased 37.96 9.77 52 373650 19216 50212206
Abnormal behaviour 37.78 9.77 54 373648 19604 50211818
Unresponsive to stimuli 37.56 9.77 109 373593 30500 50200922
Ascites 37.55 9.77 137 373565 35724 50195698
Posterior reversible encephalopathy syndrome 37.44 9.77 33 373669 14895 50216527
Pain in jaw 36.91 9.77 152 373550 38276 50193146
Pre-eclampsia 36.89 9.77 137 373565 7907 50223515
Joint stiffness 36.87 9.77 364 373338 29944 50201478
Enthesopathy 36.83 9.77 127 373575 7066 50224356
Blood pressure diastolic decreased 36.80 9.77 231 373471 16550 50214872
Platelet count decreased 36.68 9.77 523 373179 100203 50131219
Deep vein thrombosis 36.60 9.77 355 373347 72949 50158473
Localised infection 36.51 9.77 317 373385 25168 50206254
Polyarthritis 36.35 9.77 135 373567 7792 50223630
Blood alkaline phosphatase increased 36.31 9.77 148 373554 37378 50194044
Accidental overdose 36.23 9.77 55 373647 19478 50211944
Intentional product use issue 36.09 9.77 782 372920 76136 50155286
Disseminated intravascular coagulation 36.07 9.77 44 373658 17091 50214331
Metastases to liver 35.96 9.77 58 373644 20046 50211376
Ventricular septal defect 35.94 9.77 87 373615 3954 50227468
Blood bilirubin increased 35.83 9.77 119 373583 31919 50199503
Cerebral haemorrhage 35.68 9.77 93 373609 26959 50204463
Dysgeusia 35.49 9.77 157 373545 38759 50192663
Nodule 35.40 9.77 231 373471 16772 50214650
Bone pain 35.40 9.77 204 373498 47025 50184397
Maternal exposure before pregnancy 35.17 9.77 106 373596 5491 50225931
Vertigo 34.64 9.77 232 373470 51600 50179822
Flushing 34.54 9.77 322 373380 66693 50164729
Infective pulmonary exacerbation of cystic fibrosis 34.51 9.77 8 373694 7901 50223521
Injection site rash 34.43 9.77 221 373481 15956 50215466
Blood calcium decreased 34.06 9.77 63 373639 20643 50210779
Dysarthria 34.04 9.77 151 373551 37252 50194170
Brain oedema 33.96 9.77 25 373677 12345 50219077
Aspartate aminotransferase increased 33.96 9.77 390 373312 77608 50153814
Palpitations 33.95 9.77 492 373210 94014 50137408
Limb deformity 33.86 9.77 81 373621 3653 50227769
Arrhythmia 33.76 9.77 128 373574 33004 50198418
Torsade de pointes 33.70 9.77 23 373679 11812 50219610
C-reactive protein increased 33.52 9.77 683 373019 65791 50165631
Pulmonary fibrosis 33.47 9.77 301 373401 24136 50207286
Injection site bruising 33.46 9.77 417 373285 36351 50195071
Joint destruction 33.43 9.77 83 373619 3833 50227589
Device dislocation 33.32 9.77 68 373634 21478 50209944
Dysphagia 33.21 9.77 389 373313 77129 50154293
Tenderness 33.20 9.77 243 373459 18322 50213100
Chronic kidney disease 33.01 9.77 166 373536 39605 50191817
Haemorrhage 32.88 9.77 245 373457 53196 50178226
Inflammation 32.87 9.77 597 373105 56315 50175107
Premature delivery 32.69 9.77 292 373410 23371 50208051
Musculoskeletal pain 32.34 9.77 729 372973 71448 50159974
Drug ineffective for unapproved indication 32.20 9.77 68 373634 21213 50210209
Disability 31.94 9.77 182 373520 12593 50218829
Premature rupture of membranes 31.91 9.77 90 373612 4490 50226932
Small for dates baby 31.75 9.77 76 373626 3429 50227993
Anaphylactic shock 31.69 9.77 63 373639 20092 50211330
Femur fracture 31.61 9.77 419 373283 37045 50194377
Nightmare 31.10 9.77 44 373658 16042 50215380
Alanine aminotransferase increased 31.05 9.77 462 373240 87897 50143525
Akathisia 30.97 9.77 11 373691 8218 50223204
Chest pain 30.91 9.77 1033 372669 175849 50055573
Ventricular fibrillation 30.77 9.77 20 373682 10539 50220883
Diabetes mellitus inadequate control 30.69 9.77 31 373671 13114 50218308
Wrong technique in product usage process 30.68 9.77 262 373440 55248 50176174
Tenosynovitis stenosans 30.35 9.77 57 373645 2167 50229255
Heart rate decreased 30.30 9.77 407 373295 36090 50195332
Cytokine release syndrome 30.09 9.77 13 373689 8621 50222801
Pleural effusion 29.98 9.77 422 373280 81032 50150390
Neuroleptic malignant syndrome 29.90 9.77 23 373679 11107 50220315
Ventricular tachycardia 29.87 9.77 44 373658 15777 50215645
Respiratory distress 29.65 9.77 120 373582 30369 50201053
Joint range of motion decreased 29.58 9.77 236 373466 18276 50213146
Inappropriate antidiuretic hormone secretion 29.56 9.77 32 373670 13111 50218311
Withdrawal syndrome 29.39 9.77 53 373649 17537 50213885
Pulmonary oedema 29.33 9.77 226 373476 48712 50182710
Neurotoxicity 28.81 9.77 40 373662 14700 50216722
Smear cervix abnormal 28.77 9.77 63 373639 2678 50228744
Psychotic disorder 28.76 9.77 75 373627 21737 50209685
Synovial cyst 28.65 9.77 128 373574 8038 50223384
Acute respiratory failure 28.17 9.77 113 373589 28669 50202753
Tenosynovitis 28.07 9.77 153 373549 10412 50221010
Toxic skin eruption 28.07 9.77 25 373677 11226 50220196
Hypomagnesaemia 28.02 9.77 83 373619 23073 50208349
Blood pressure diastolic increased 27.89 9.77 119 373583 7324 50224098
Atrial fibrillation 27.69 9.77 557 373145 101188 50130234
Schizophrenia 27.65 9.77 10 373692 7387 50224035
Latent tuberculosis 27.57 9.77 55 373647 2188 50229234
Dyskinesia 27.51 9.77 109 373593 27752 50203670
Immune reconstitution inflammatory syndrome 27.45 9.77 4 373698 5512 50225910
International normalised ratio increased 27.42 9.77 196 373506 42956 50188466
Cerebrovascular accident 27.39 9.77 513 373189 94167 50137255
Device difficult to use 27.11 9.77 20 373682 9866 50221556
Gastrointestinal haemorrhage 26.94 9.77 380 373322 72941 50158481
Blood creatinine increased 26.83 9.77 398 373304 75762 50155660
Laryngitis 26.68 9.77 155 373547 10801 50220621
Coagulopathy 26.60 9.77 58 373644 17886 50213536
Wheelchair user 26.52 9.77 89 373613 4883 50226539
Dysmorphism 26.47 9.77 53 373649 2114 50229308
Irritability 26.33 9.77 114 373588 28312 50203110
Pulmonary hypertension 26.31 9.77 142 373560 33275 50198147
Eosinophilia 26.26 9.77 62 373640 18590 50212832
Melaena 25.96 9.77 106 373596 26758 50204664
Drug tolerance decreased 25.94 9.77 135 373567 9025 50222397
Metastases to central nervous system 25.90 9.77 27 373675 11255 50220167
Skin ulcer 25.77 9.77 385 373317 34933 50196489
Polyneuropathy 25.69 9.77 31 373671 12100 50219322
Arthritis infective 25.67 9.77 95 373607 5474 50225948
Crying 25.56 9.77 72 373630 20344 50211078
Skin papilloma 25.55 9.77 79 373623 4150 50227272
Bronchospasm 25.50 9.77 44 373658 14810 50216612
Parkinsonism 25.45 9.77 17 373685 8830 50222592
Obstructive airways disorder 25.41 9.77 48 373654 15604 50215818
Bradyphrenia 25.34 9.77 7 373695 6145 50225277
Macular degeneration 25.28 9.77 42 373660 14346 50217076
Malignant melanoma 25.27 9.77 144 373558 9964 50221458
Mania 25.20 9.77 26 373676 10890 50220532
Atrioventricular block complete 25.16 9.77 11 373691 7244 50224178
Pain in extremity 25.04 9.77 2340 371362 270525 49960897
Ischaemic stroke 24.94 9.77 50 373652 15898 50215524
Asphyxia 24.67 9.77 5 373697 5422 50226000
Back pain 24.60 9.77 1351 372351 218679 50012743
Jaundice 24.48 9.77 106 373596 26323 50205099
Transplant rejection 24.39 9.77 21 373681 9588 50221834
Neck mass 24.36 9.77 67 373635 3294 50228128
Oedema peripheral 24.29 9.77 937 372765 157024 50074398
Stress cardiomyopathy 24.29 9.77 14 373688 7873 50223549
Developmental hip dysplasia 24.08 9.77 38 373664 1253 50230169
Placental disorder 23.83 9.77 40 373662 1390 50230032
Thrombotic microangiopathy 23.83 9.77 18 373684 8773 50222649
Face oedema 23.78 9.77 61 373641 17778 50213644
Sepsis 23.75 9.77 774 372928 132151 50099271
Synovial fluid analysis 23.64 9.77 43 373659 1595 50229827
Device use error 23.63 9.77 5 373697 5261 50226161
Acute generalised exanthematous pustulosis 23.35 9.77 19 373683 8919 50222503
Abdominal distension 23.31 9.77 388 373314 72515 50158907
Fear 23.28 9.77 45 373657 14504 50216918
Aggression 23.22 9.77 79 373623 21037 50210385
Second primary malignancy 23.17 9.77 11 373691 6903 50224519
Paralysis 23.16 9.77 18 373684 8646 50222776
Tumour lysis syndrome 23.10 9.77 13 373689 7408 50224014
Hypomania 23.05 9.77 3 373699 4502 50226920
Pancreatitis acute 22.98 9.77 94 373608 23718 50207704
Myoclonus 22.94 9.77 45 373657 14425 50216997
Haematotoxicity 22.94 9.77 15 373687 7880 50223542
Spinal stenosis 22.89 9.77 175 373527 13375 50218047
Oropharyngeal pain 22.88 9.77 744 372958 77057 50154365
Febrile bone marrow aplasia 22.81 9.77 9 373693 6302 50225120
Blood potassium decreased 22.42 9.77 170 373532 36775 50194647
Product adhesion issue 22.29 9.77 3 373699 4389 50227033
Accidental exposure to product 22.26 9.77 91 373611 22966 50208456
Stomatitis 22.26 9.77 938 372764 100406 50131016
Rotator cuff repair 22.21 9.77 43 373659 1673 50229749
Acute myeloid leukaemia 22.11 9.77 49 373653 15025 50216397
Hypervolaemia 21.98 9.77 105 373597 25394 50206028
Pyrexia 21.98 9.77 2465 371237 377738 49853684
Graft versus host disease 21.95 9.77 9 373693 6157 50225265
Muscular weakness 21.88 9.77 534 373168 94479 50136943
Depressed mood 21.88 9.77 154 373548 33869 50197553
Loose body in joint 21.87 9.77 35 373667 1168 50230254
Polyhydramnios 21.78 9.77 47 373655 1978 50229444
Dystonia 21.71 9.77 34 373668 11892 50219530
Agranulocytosis 21.67 9.77 83 373619 21338 50210084
Panic attack 21.52 9.77 72 373630 19270 50212152
Pulmonary tuberculosis 21.49 9.77 75 373627 4198 50227224
Abdominal pain 21.40 9.77 1479 372223 234749 49996673
Hemiparesis 21.38 9.77 76 373626 19972 50211450
Postoperative wound infection 21.36 9.77 121 373581 8354 50223068
Miosis 21.21 9.77 10 373692 6300 50225122
Complication of device insertion 21.21 9.77 9 373693 6032 50225390
Therapeutic response decreased 21.14 9.77 477 373225 46754 50184668
Product dose omission issue 21.05 9.77 1126 372576 182712 50048710
Pancreatitis 21 9.77 207 373495 42407 50189015
Cardiac failure acute 20.98 9.77 18 373684 8232 50223190
Unevaluable event 20.97 9.77 228 373474 45838 50185584
Tardive dyskinesia 20.92 9.77 14 373688 7265 50224157
COVID-19 20.82 9.77 232 373470 46430 50184992
Gastroenteritis viral 20.65 9.77 221 373481 18565 50212857
Anhedonia 20.53 9.77 24 373678 9500 50221922
Confusional state 20.51 9.77 1143 372559 184785 50046637
Substance abuse 20.50 9.77 3 373699 4121 50227301
Body temperature decreased 20.47 9.77 198 373504 16197 50215225
Atrial septal defect 20.47 9.77 97 373605 6244 50225178
Lethargy 20.42 9.77 250 373452 49182 50182240
Cardiogenic shock 20.29 9.77 54 373648 15545 50215877
Cytopenia 20.14 9.77 21 373681 8754 50222668
Joint dislocation 20.13 9.77 158 373544 12175 50219247
Tachypnoea 20.09 9.77 49 373653 14528 50216894
Rash maculo-papular 20.00 9.77 115 373587 26526 50204896
Herpes zoster 19.81 9.77 673 373029 70113 50161309
Genital haemorrhage 19.78 9.77 12 373690 6562 50224860
Complication associated with device 19.62 9.77 50 373652 14605 50216817
Dementia 19.60 9.77 57 373645 15940 50215482
Body height below normal 19.56 9.77 44 373658 1905 50229517
Disease recurrence 19.55 9.77 79 373623 20002 50211420
Glycosylated haemoglobin increased 19.54 9.77 30 373672 10576 50220846
Hyperlipidaemia 19.53 9.77 65 373637 17425 50213997
Metastases to lung 19.51 9.77 32 373670 10988 50220434
Psychomotor hyperactivity 19.45 9.77 24 373678 9277 50222145
Foetal death 19.45 9.77 115 373587 8065 50223357
Acute graft versus host disease 19.40 9.77 3 373699 3955 50227467
Nervousness 19.37 9.77 122 373580 27529 50203893
Erythema multiforme 19.30 9.77 23 373679 9027 50222395
Acute chest syndrome 19.22 9.77 24 373678 633 50230789
Haemorrhage intracranial 19.18 9.77 39 373663 12335 50219087
Urinary retention 19.15 9.77 114 373588 26076 50205346
Injection site warmth 19.09 9.77 171 373531 13695 50217727
Stevens-Johnson syndrome 19.09 9.77 89 373613 21663 50209759
Headache 18.97 9.77 3372 370330 503163 49728259
Red blood cell sedimentation rate 18.96 9.77 64 373638 3522 50227900
Uterine perforation 18.90 9.77 12 373690 6403 50225019
Pemphigoid 18.89 9.77 10 373692 5897 50225525
Maternal exposure timing unspecified 18.61 9.77 64 373638 3556 50227866
Plasma cell myeloma 18.60 9.77 145 373557 31177 50200245
Foetal anticonvulsant syndrome 18.53 9.77 22 373680 550 50230872
Status epilepticus 18.52 9.77 45 373657 13361 50218061
Joint injury 18.51 9.77 244 373458 21545 50209877
Sinus tachycardia 18.37 9.77 88 373614 21266 50210156
Haemophagocytic lymphohistiocytosis 18.35 9.77 22 373680 8611 50222811
Subdural haematoma 18.25 9.77 43 373659 12904 50218518
Congenital arterial malformation 18.15 9.77 17 373685 320 50231102
Antinuclear antibody positive 18.15 9.77 93 373609 6179 50225243
Cholecystitis chronic 18.15 9.77 27 373675 9642 50221780
Joint noise 18.08 9.77 63 373639 3524 50227898
Fear of injection 18.02 9.77 91 373611 6012 50225410
Shock haemorrhagic 18.02 9.77 21 373681 8323 50223099
Crohn's disease 17.99 9.77 76 373626 4657 50226765
Oral herpes 17.98 9.77 233 373469 20492 50210930
Atrioventricular block 17.90 9.77 13 373689 6465 50224957
Clear cell renal cell carcinoma 17.89 9.77 32 373670 1171 50230251
Infusion site erythema 17.75 9.77 23 373679 8704 50222718
Leukocytosis 17.75 9.77 96 373606 22483 50208939
Haemorrhage in pregnancy 17.62 9.77 39 373663 1670 50229752
Dactylitis 17.56 9.77 41 373661 1820 50229602
Mood altered 17.55 9.77 43 373659 12730 50218692
Device related infection 17.52 9.77 86 373616 20649 50210773
Cushingoid 17.50 9.77 96 373606 6549 50224873
Synovial disorder 17.50 9.77 27 373675 873 50230549
Gestational hypertension 17.45 9.77 45 373657 2128 50229294
Scleritis 17.42 9.77 58 373644 3169 50228253
Exposure to toxic agent 17.42 9.77 3 373699 3655 50227767
Lupus-like syndrome 17.41 9.77 125 373577 9366 50222056
Infusion site pain 17.41 9.77 41 373661 12305 50219117
Skin cancer 17.40 9.77 124 373578 9270 50222152
Paradoxical drug reaction 17.35 9.77 3 373699 3644 50227778
Hallucination, auditory 17.33 9.77 33 373669 10695 50220727
Breast feeding 17.28 9.77 26 373676 822 50230600
Salivary hypersecretion 17.23 9.77 14 373688 6577 50224845
Incorrect route of product administration 17.20 9.77 75 373627 18591 50212831
Myocarditis 17.16 9.77 20 373682 7927 50223495
Labelled drug-drug interaction medication error 17.12 9.77 32 373670 10445 50220977
Hypertransaminasaemia 17.11 9.77 3 373699 3608 50227814
Stillbirth 17.05 9.77 88 373614 5864 50225558
Proteinuria 16.98 9.77 64 373638 16533 50214889
Lymphocyte count decreased 16.95 9.77 119 373583 26188 50205234
Ketoacidosis 16.87 9.77 4 373698 3891 50227531
Haematoma 16.85 9.77 144 373558 30366 50201056
Myopathy 16.69 9.77 26 373676 9113 50222309
Complication of device removal 16.67 9.77 5 373697 4159 50227263
Fracture 16.66 9.77 194 373508 16639 50214783
Talipes 16.58 9.77 34 373668 1380 50230042
Clostridium difficile colitis 16.53 9.77 71 373631 17671 50213751
Dry skin 16.52 9.77 222 373480 42969 50188453
Multiple allergies 16.51 9.77 23 373679 8440 50222982
Aphasia 16.41 9.77 133 373569 28361 50203061
Sleep apnoea syndrome 16.36 9.77 106 373596 23762 50207660
Haemoptysis 16.32 9.77 116 373586 25457 50205965
Hypophosphataemia 16.28 9.77 23 373679 8391 50223031
Dislocation of vertebra 16.24 9.77 55 373647 3032 50228390
Hepatotoxicity 16.18 9.77 126 373576 27100 50204322
Fracture delayed union 16.13 9.77 45 373657 2231 50229191
Off label use 16.05 9.77 3175 370527 471251 49760171
Acidosis 16.05 9.77 32 373670 10195 50221227
Cardiomyopathy 16.02 9.77 60 373642 15526 50215896
Oedema 16.00 9.77 395 373307 69786 50161636
Tubulointerstitial nephritis 16.00 9.77 58 373644 15153 50216269
Wheezing 15.89 9.77 343 373359 61704 50169718
Skin exfoliation 15.85 9.77 165 373537 33447 50197975
Mouth ulceration 15.84 9.77 293 373409 27731 50203691
Respiration abnormal 15.79 9.77 9 373693 5093 50226329
Hallucination, visual 15.66 9.77 66 373636 16516 50214906
Immunodeficiency 15.63 9.77 173 373529 14655 50216767
Multiple sclerosis 15.63 9.77 88 373614 20405 50211017
Injection site haematoma 15.59 9.77 87 373615 5973 50225449
Pharyngitis streptococcal 15.58 9.77 115 373587 8693 50222729
Hyperprolactinaemia 15.51 9.77 3 373699 3362 50228060
Neonatal respiratory distress syndrome 15.50 9.77 49 373653 2605 50228817
Muscle twitching 15.47 9.77 60 373642 15371 50216051
Bone marrow failure 15.43 9.77 130 373572 27494 50203928
Catheter site erythema 15.43 9.77 5 373697 3957 50227465
Human antichimeric antibody positive 15.38 9.77 34 373668 1455 50229967
Generalised oedema 15.35 9.77 51 373651 13680 50217742
Diabetes mellitus 15.33 9.77 262 373440 48771 50182651
Temperature regulation disorder 15.32 9.77 6 373696 4221 50227201
Cerebral infarction 15.30 9.77 95 373607 21509 50209913
Hypophagia 15.26 9.77 131 373571 27597 50203825
Angina pectoris 15.19 9.77 122 373580 26066 50205356
Poor venous access 15.01 9.77 129 373573 10211 50221211
Delusion 14.98 9.77 35 373667 10534 50220888
Pathogen resistance 14.98 9.77 12 373690 5677 50225745
Aspergillus infection 14.91 9.77 17 373685 6804 50224618
Rash erythematous 14.88 9.77 175 373527 34677 50196745
Affective disorder 14.84 9.77 10 373692 5171 50226251
Pulmonary congestion 14.83 9.77 60 373642 15187 50216235
Antibody test positive 14.74 9.77 44 373658 2267 50229155
Vascular device infection 14.66 9.77 7 373695 4377 50227045
Blood glucose decreased 14.55 9.77 77 373625 18134 50213288
Aspiration 14.53 9.77 29 373673 9235 50222187
Infusion site swelling 14.51 9.77 19 373683 7157 50224265
Speech disorder developmental 14.45 9.77 20 373682 585 50230837
Bronchopulmonary aspergillosis 14.44 9.77 21 373681 7571 50223851
Gastrointestinal disorder 14.43 9.77 844 372858 93612 50137810
Oliguria 14.42 9.77 24 373678 8192 50223230
Product prescribing error 14.41 9.77 93 373609 20868 50210554
Muscle rigidity 14.38 9.77 32 373670 9797 50221625
Pseudomonas infection 14.38 9.77 30 373672 9400 50222022
Bone disorder 14.30 9.77 206 373496 18546 50212876
Exomphalos 14.30 9.77 19 373683 534 50230888
Polyuria 14.25 9.77 19 373683 7102 50224320
Squamous cell carcinoma 14.24 9.77 102 373600 7637 50223785
Cholestasis of pregnancy 14.22 9.77 28 373674 1103 50230319
Malaise 14.21 9.77 2218 371484 333314 49898108
Catheter site pain 14.21 9.77 5 373697 3757 50227665
Bundle branch block left 14.20 9.77 15 373687 6215 50225207
Tendonitis 14.16 9.77 187 373515 16518 50214904
Surgery 14.13 9.77 307 373395 29898 50201524
Pericardial effusion 14.03 9.77 121 373581 25468 50205954
Device breakage 14.03 9.77 31 373671 9516 50221906
Lip swelling 14 9.77 116 373586 24620 50206802
Toxic epidermal necrolysis 14 9.77 94 373608 20898 50210524
Cyanosis 14.00 9.77 61 373641 15123 50216299
Right ventricular failure 13.96 9.77 65 373637 15828 50215594
Blood iron increased 13.86 9.77 31 373671 1337 50230085
Joint lock 13.82 9.77 40 373662 2025 50229397
Anuria 13.82 9.77 40 373662 11204 50220218
Immunosuppression 13.74 9.77 98 373604 7328 50224094
Influenza 13.67 9.77 800 372902 88738 50142684
Autism spectrum disorder 13.54 9.77 21 373681 682 50230740
Foetal distress syndrome 13.51 9.77 29 373673 1216 50230206
Renal injury 13.46 9.77 27 373675 8584 50222838
Colitis microscopic 13.45 9.77 17 373685 6503 50224919
Hypertelorism 13.45 9.77 16 373686 401 50231021
Anger 13.44 9.77 41 373661 11292 50220130
Dysuria 13.41 9.77 140 373562 28364 50203058
Abdominal pain upper 13.35 9.77 1004 372698 158305 50073117
Induced labour 13.20 9.77 24 373678 890 50230532
Coronary artery disease 13.18 9.77 148 373554 29578 50201844
Hot flush 13.18 9.77 238 373464 43931 50187491
Urinary incontinence 13.08 9.77 139 373563 28069 50203353
Cervical incompetence 13.04 9.77 19 373683 583 50230839
Hallucinations, mixed 13.04 9.77 7 373695 4096 50227326
Tumour marker increased 13.04 9.77 6 373696 3834 50227588
Visual acuity reduced 13.03 9.77 91 373611 20048 50211374
Hepatic cytolysis 13.02 9.77 25 373677 8078 50223344
Colitis 13.00 9.77 203 373499 38326 50193096
Occult blood 12.96 9.77 28 373674 1179 50230243
Mental disorder 12.96 9.77 102 373600 21889 50209533
Ankylosing spondylitis 12.93 9.77 94 373608 7071 50224351
Wound infection 12.93 9.77 142 373560 12006 50219416
Tongue disorder 12.87 9.77 114 373588 9102 50222320
Personality disorder 12.86 9.77 8 373694 4316 50227106
Ulcer 12.77 9.77 215 373487 19985 50211437
Sinus bradycardia 12.75 9.77 52 373650 13131 50218291
Arthritis bacterial 12.66 9.77 78 373624 5551 50225871
Myelosuppression 12.65 9.77 54 373648 13463 50217959
Product substitution issue 12.64 9.77 57 373645 14000 50217422
Klebsiella infection 12.64 9.77 21 373681 7173 50224249
Joint warmth 12.60 9.77 30 373672 1349 50230073
Therapy change 12.57 9.77 12 373690 5213 50226209
Visual impairment 12.56 9.77 396 373306 67879 50163543
Lymphatic fistula 12.53 9.77 21 373681 729 50230693
Hereditary angioedema 12.52 9.77 13 373689 5429 50225993
Malignant mediastinal neoplasm 12.51 9.77 18 373684 546 50230876
Hyperthyroidism 12.43 9.77 47 373655 12128 50219294
Foot fracture 12.40 9.77 213 373489 19878 50211544
Eating disorder 12.40 9.77 65 373637 15344 50216078
Paraesthesia 12.38 9.77 744 372958 119499 50111923
Purpura 12.37 9.77 35 373667 9876 50221546
Femoral hernia incarcerated 12.30 9.77 21 373681 740 50230682
Serum ferritin increased 12.28 9.77 73 373629 5129 50226293
Injection site irritation 12.24 9.77 64 373638 4286 50227136
Transplant dysfunction 12.18 9.77 10 373692 4674 50226748
Human anti-human antibody test 12.18 9.77 15 373687 390 50231032
Maternal exposure during breast feeding 12.17 9.77 52 373650 3202 50228220
Dermatitis exfoliative 12.15 9.77 12 373690 5130 50226292
Respiratory acidosis 12.14 9.77 16 373686 6012 50225410
Tendon disorder 12.13 9.77 74 373628 5248 50226174
Infusion site pruritus 12.11 9.77 7 373695 3930 50227492
Drug abuser 12.06 9.77 3 373699 2825 50228597
Polydipsia 12.06 9.77 4 373698 3120 50228302
Acute pulmonary oedema 12.05 9.77 22 373680 7245 50224177
Patent ductus arteriosus 12.02 9.77 58 373644 3762 50227660
Trigeminal neuralgia 12.01 9.77 4 373698 3111 50228311
Pulseless electrical activity 11.99 9.77 20 373682 6821 50224601
Bundle branch block right 11.98 9.77 10 373692 4635 50226787
Wound infection pseudomonas 11.96 9.77 28 373674 1245 50230177
Endodontic procedure 11.96 9.77 46 373656 2700 50228722
Pneumonia viral 11.96 9.77 20 373682 6814 50224608
Pancytopenia 11.93 9.77 746 372956 83284 50148138
Treatment noncompliance 11.88 9.77 154 373548 29996 50201426
Product complaint 11.87 9.77 44 373658 11422 50220000
Bronchitis 11.86 9.77 908 372794 103251 50128171
Abortion missed 11.85 9.77 32 373670 1556 50229866
Product preparation error 11.79 9.77 9 373693 4363 50227059
Renal disorder 11.78 9.77 138 373564 27367 50204055
Toxic encephalopathy 11.78 9.77 14 373688 5501 50225921
Cardiac disorder 11.77 9.77 235 373467 42744 50188678
Epstein-Barr virus infection 11.76 9.77 21 373681 6976 50224446
Swollen tongue 11.75 9.77 145 373557 28485 50202937
Acute myocardial infarction 11.73 9.77 149 373553 29124 50202298
Systemic inflammatory response syndrome 11.68 9.77 12 373690 5037 50226385
Bone density abnormal 11.65 9.77 49 373653 2996 50228426
Drug-induced liver injury 11.64 9.77 142 373560 27953 50203469
Abortion threatened 11.57 9.77 17 373685 526 50230896
Lymphoedema 11.55 9.77 32 373670 9090 50222332
Multiple-drug resistance 11.53 9.77 5 373697 3309 50228113
Pregnancy with contraceptive device 11.52 9.77 8 373694 4071 50227351
Blood loss anaemia 11.50 9.77 27 373675 8112 50223310
Food allergy 11.49 9.77 27 373675 8110 50223312
Potentiating drug interaction 11.43 9.77 7 373695 3809 50227613
Ingrown hair 11.43 9.77 16 373686 473 50230949
Sexual dysfunction 11.40 9.77 5 373697 3287 50228135
Amylase increased 11.37 9.77 14 373688 5416 50226006
Pulmonary haemorrhage 11.36 9.77 19 373683 6473 50224949
Rheumatoid lung 11.32 9.77 42 373660 2423 50228999
Anterior chamber cleavage syndrome 11.32 9.77 10 373692 174 50231248
Learning disorder 11.26 9.77 18 373684 600 50230822
Knee operation 11.26 9.77 68 373634 4805 50226617
Crystal nephropathy 11.26 9.77 21 373681 794 50230628
Circulatory collapse 11.22 9.77 94 373608 19906 50211516
Renal tubular necrosis 11.21 9.77 38 373664 10130 50221292
Progressive multifocal leukoencephalopathy 11.20 9.77 45 373657 11412 50220010
Paranoia 11.19 9.77 39 373663 10309 50221113
Bone lesion 11.17 9.77 13 373689 5157 50226265
Lung adenocarcinoma 11.07 9.77 60 373642 4074 50227348
Affect lability 11.07 9.77 32 373670 8966 50222456
Abnormal dreams 11.06 9.77 34 373668 9343 50222079
Somnambulism 11.06 9.77 12 373690 4912 50226510
Cardiotoxicity 11.02 9.77 22 373680 7005 50224417
Plasma cell myeloma recurrent 10.99 9.77 3 373699 2655 50228767
Catatonia 10.99 9.77 7 373695 3729 50227693
Adverse event 10.99 9.77 411 373291 43352 50188070
Presyncope 10.92 9.77 120 373582 24078 50207344
Alanine aminotransferase abnormal 10.92 9.77 60 373642 4096 50227326
Forceps delivery 10.91 9.77 10 373692 183 50231239
Peripheral sensory neuropathy 10.89 9.77 20 373682 6571 50224851
Myofascial pain syndrome 10.86 9.77 37 373665 2046 50229376
Coronary arterial stent insertion 10.84 9.77 3 373699 2631 50228791
Product administered to patient of inappropriate age 10.82 9.77 3 373699 2627 50228795
Inflammatory marker increased 10.80 9.77 75 373627 5559 50225863
Bradykinesia 10.78 9.77 8 373694 3935 50227487
Hepatitis acute 10.78 9.77 27 373675 7934 50223488
Placental insufficiency 10.78 9.77 27 373675 1254 50230168
Carpal tunnel syndrome 10.75 9.77 180 373522 16713 50214709
Intervertebral disc degeneration 10.72 9.77 149 373553 13312 50218110
Taste disorder 10.69 9.77 29 373673 8295 50223127
Chondropathy 10.68 9.77 37 373665 2063 50229359
Haematocrit decreased 10.68 9.77 336 373366 34640 50196782
Stress at work 10.64 9.77 24 373678 1041 50230381
Pleuritic pain 10.64 9.77 83 373619 6383 50225039
Troponin increased 10.63 9.77 28 373674 8090 50223332
Lymphadenectomy 10.58 9.77 22 373680 902 50230520
Nail injury 10.57 9.77 15 373687 449 50230973
Chills 10.54 9.77 595 373107 96092 50135330
Drug screen positive 10.53 9.77 6 373696 3396 50228026
Threatened labour 10.53 9.77 20 373682 767 50230655
Pancreatic steatosis 10.50 9.77 22 373680 907 50230515
Head injury 10.49 9.77 120 373582 23900 50207522
Abortion incomplete 10.44 9.77 5 373697 3121 50228301
Ankyloglossia congenital 10.44 9.77 10 373692 194 50231228
Eosinophil count increased 10.43 9.77 32 373670 8798 50222624
Vacuum extractor delivery 10.41 9.77 9 373693 152 50231270
Inadequate analgesia 10.37 9.77 3 373699 2555 50228867
Product physical issue 10.36 9.77 10 373692 4322 50227100
Congenital hydronephrosis 10.36 9.77 14 373688 400 50231022
Acute coronary syndrome 10.36 9.77 35 373667 9339 50222083
Embedded device 10.33 9.77 4 373698 2833 50228589
Body temperature increased 10.28 9.77 166 373536 31175 50200247
Retinitis 10.26 9.77 34 373668 1853 50229569
Lung transplant 10.26 9.77 4 373698 2821 50228601
Restless legs syndrome 10.20 9.77 72 373630 15825 50215597
Ileus paralytic 10.10 9.77 9 373693 4041 50227381
Retrognathia 10.10 9.77 14 373688 410 50231012
Haemodialysis 10.10 9.77 30 373672 8332 50223090
Ataxia 10.08 9.77 60 373642 13726 50217696
Rhinitis allergic 10.08 9.77 24 373678 7176 50224246
Osteoporotic fracture 10.07 9.77 48 373654 3097 50228325
Incorrect product administration duration 10.00 9.77 35 373667 9240 50222182
Nystagmus 9.99 9.77 16 373686 5545 50225877
Pulmonary alveolar haemorrhage 9.98 9.77 9 373693 4018 50227404
Blood phosphorus decreased 9.97 9.77 8 373694 3781 50227641
Intracranial pressure increased 9.96 9.77 10 373692 4242 50227180
Breast cancer metastatic 9.95 9.77 41 373661 10323 50221099
Renal mass 9.94 9.77 34 373668 1884 50229538
Metabolic encephalopathy 9.91 9.77 14 373688 5107 50226315
Oxygen consumption increased 9.90 9.77 7 373695 3529 50227893
Hyperuricaemia 9.87 9.77 12 373690 4668 50226754
Incoherent 9.85 9.77 10 373692 4220 50227202
Device issue 9.84 9.77 97 373605 19875 50211547

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 530.97 9.88 691 133439 31461 29408936
Foetal exposure during pregnancy 305.75 9.88 550 133580 33317 29407080
Drug abuse 296.83 9.88 16 134114 79867 29360530
Toxicity to various agents 223.18 9.88 276 133854 173385 29267012
Arthralgia 215.91 9.88 1222 132908 138395 29302002
Completed suicide 199.11 9.88 80 134050 90166 29350231
Psoriatic arthropathy 156.70 9.88 257 133873 14434 29425963
Dysmorphism 132.38 9.88 109 134021 2862 29437535
Drug interaction 116.68 9.88 480 133650 196905 29243492
Joint swelling 109.59 9.88 481 133649 49149 29391248
Sickle cell anaemia with crisis 108.57 9.88 92 134038 2516 29437881
Premature baby 103.73 9.88 237 133893 17043 29423354
Psoriasis 89.98 9.88 336 133794 31891 29408506
Enthesopathy 89.06 9.88 97 134033 3646 29436751
Exposure during pregnancy 86.33 9.88 146 133984 8408 29431989
Intentional overdose 81.94 9.88 36 134094 38492 29401905
Speech disorder developmental 78.83 9.88 67 134063 1840 29438557
Neonatal respiratory distress syndrome 74.18 9.88 89 134041 3721 29436676
Tenosynovitis 73.99 9.88 88 134042 3645 29436752
Blood pressure fluctuation 72.73 9.88 227 133903 19667 29420730
Musculoskeletal stiffness 70.83 9.88 347 133783 37111 29403286
Acute kidney injury 70.46 9.88 817 133313 264450 29175947
Atrial septal defect 67.36 9.88 115 134015 6674 29433723
Hypospadias 66.60 9.88 75 134055 2927 29437470
Foetal anticonvulsant syndrome 65.46 9.88 49 134081 1115 29439282
Nasopharyngitis 62.46 9.88 474 133656 59191 29381206
Pain 59.92 9.88 1101 133029 170331 29270066
Death 59.55 9.88 1144 132986 340940 29099457
Maternal drugs affecting foetus 58.55 9.88 80 134050 3813 29436584
Overdose 58.49 9.88 177 133953 79642 29360755
Synovitis 58.45 9.88 143 133987 10747 29429650
Drug reaction with eosinophilia and systemic symptoms 58.20 9.88 27 134103 27965 29412432
Maternal exposure during pregnancy 57.93 9.88 82 134048 4041 29436356
Autism spectrum disorder 57.92 9.88 58 134072 1974 29438423
Low birth weight baby 55.39 9.88 104 134026 6504 29433893
Small for dates baby 53.00 9.88 73 134057 3506 29436891
Product use in unapproved indication 52.62 9.88 209 133921 86666 29353731
C-reactive protein abnormal 52.48 9.88 101 134029 6435 29433962
Cryptorchism 50.93 9.88 53 134077 1889 29438508
Learning disorder 50.85 9.88 40 134090 982 29439415
Hypoglycaemia neonatal 50.60 9.88 50 134080 1674 29438723
Suicide attempt 50.57 9.88 48 134082 34062 29406335
Arthritis 48.17 9.88 233 133897 24786 29415611
Coma 47.15 9.88 66 134064 39384 29401013
Serotonin syndrome 46.69 9.88 11 134119 17501 29422896
Tongue disorder 46.61 9.88 79 134051 4557 29435840
Hepatic function abnormal 46.60 9.88 66 134064 39193 29401204
Ventricular septal defect 46.38 9.88 68 134062 3461 29436936
Maternal exposure during breast feeding 45.30 9.88 44 134086 1442 29438955
Drug resistance 44.43 9.88 21 134109 21519 29418878
Rhabdomyolysis 43.71 9.88 136 133994 60672 29379725
Foot deformity 42.48 9.88 70 134060 3945 29436452
Palmar-plantar erythrodysaesthesia syndrome 41.96 9.88 8 134122 14751 29425646
Arthropathy 40.25 9.88 199 133931 21355 29419042
Syndactyly 40.00 9.88 31 134099 744 29439653
Pulmonary fibrosis 39.82 9.88 158 133972 15424 29424973
Febrile neutropenia 39.25 9.88 323 133807 111917 29328480
Basal cell carcinoma 38.91 9.88 166 133964 16744 29423653
Rheumatoid nodule 38.76 9.88 48 134082 2074 29438323
Drug intolerance 38.74 9.88 362 133768 48017 29392380
Developmental delay 38.25 9.88 52 134078 2466 29437931
Lower respiratory tract infection 37.57 9.88 227 133903 26275 29414122
Haemoglobin decreased 37.43 9.88 695 133435 107680 29332717
Osteoarthritis 37.33 9.88 172 133958 17931 29422466
Blood pressure systolic increased 36.95 9.88 163 133967 16682 29423715
Exposure via breast milk 36.67 9.88 42 134088 1670 29438727
Pancytopenia 35.89 9.88 553 133577 82615 29357782
Intentional product misuse 35.72 9.88 64 134066 34597 29405800
Drug dependence 35.44 9.88 26 134104 20955 29419442
Joint laxity 34.92 9.88 22 134108 374 29440023
Infusion related reaction 34.44 9.88 327 133803 43559 29396838
Tendonitis 34.00 9.88 96 134034 7865 29432532
Congenital hand malformation 33.89 9.88 25 134105 556 29439841
Talipes 33.48 9.88 41 134089 1751 29438646
Alanine aminotransferase abnormal 33.25 9.88 53 134077 2904 29437493
Blood pressure increased 33.10 9.88 494 133636 73309 29367088
Bradycardia 33.05 9.88 169 133961 65460 29374937
Jaundice neonatal 32.44 9.88 34 134096 1222 29439175
Angioedema 31.93 9.88 60 134070 31855 29408542
Blood pressure systolic abnormal 31.88 9.88 44 134086 2117 29438280
Hypermobility syndrome 31.85 9.88 20 134110 338 29440059
Intellectual disability 31.57 9.88 32 134098 1105 29439292
Foetal growth restriction 31.23 9.88 59 134071 3707 29436690
Respiratory arrest 31.08 9.88 43 134087 25790 29414607
Language disorder 30.59 9.88 41 134089 1918 29438479
Pain in extremity 30.46 9.88 685 133445 109748 29330649
Renal failure 30.31 9.88 368 133762 118231 29322166
Delirium 29.82 9.88 86 134044 39311 29401086
Joint effusion 29.21 9.88 61 134069 4123 29436274
Cytomegalovirus infection 28.58 9.88 38 134092 23177 29417220
Large for dates baby 28.43 9.88 27 134103 860 29439537
Off label use 28.34 9.88 1097 133033 299703 29140694
Drug withdrawal syndrome 28.22 9.88 24 134106 17960 29422437
Polyarthritis 28.11 9.88 58 134072 3887 29436510
Hyperglycaemia 28.09 9.88 72 134058 34215 29406182
Plagiocephaly 27.94 9.88 21 134109 481 29439916
Serum ferritin increased 27.49 9.88 71 134059 5517 29434880
Peripheral swelling 27.17 9.88 423 133707 63316 29377081
Suicidal ideation 26.85 9.88 75 134055 34641 29405756
Somnolence 26.56 9.88 285 133845 93670 29346727
Hyperbilirubinaemia neonatal 26.52 9.88 24 134106 718 29439679
Cardiac failure 26.42 9.88 231 133899 79056 29361341
Hypoglycaemia 26.37 9.88 121 134009 48225 29392172
Loss of personal independence in daily activities 25.98 9.88 201 133929 25239 29415158
Skin cancer 25.92 9.88 91 134039 8377 29432020
Musculoskeletal pain 25.92 9.88 222 133908 28731 29411666
Knee deformity 25.87 9.88 21 134109 540 29439857
Knee arthroplasty 25.74 9.88 71 134059 5738 29434659
Constipation 25.24 9.88 365 133765 113795 29326602
Sedation 25.20 9.88 25 134105 17380 29423017
Caesarean section 25.19 9.88 37 134093 1886 29438511
Lactic acidosis 25.18 9.88 63 134067 30184 29410213
Hand deformity 25.09 9.88 39 134091 2091 29438306
Dysgraphia 24.97 9.88 38 134092 2000 29438397
Motor developmental delay 24.88 9.88 22 134108 638 29439759
Selective eating disorder 24.74 9.88 34 134096 1629 29438768
Astigmatism 24.46 9.88 26 134104 950 29439447
Behaviour disorder 24.41 9.88 52 134078 3564 29436833
Drug withdrawal syndrome neonatal 24.29 9.88 50 134080 3345 29437052
Agitation 24.22 9.88 135 133995 51169 29389228
Depressed level of consciousness 24.22 9.88 86 134044 36856 29403541
Multiple organ dysfunction syndrome 24.21 9.88 177 133953 62939 29377458
Disease progression 24.16 9.88 246 133884 81670 29358727
Psychotic disorder 23.38 9.88 35 134095 20319 29420078
Otitis media 23.27 9.88 42 134088 2547 29437850
Altered state of consciousness 23.04 9.88 34 134096 19855 29420542
Blood pressure diastolic decreased 22.84 9.88 77 134053 6945 29433452
Strabismus 22.67 9.88 30 134100 1386 29439011
Hypotonia neonatal 22.59 9.88 28 134102 1211 29439186
Body temperature decreased 22.49 9.88 102 134028 10562 29429835
Blood pressure diastolic abnormal 22.45 9.88 41 134089 2510 29437887
Cardiac arrest 22.08 9.88 265 133865 85326 29355071
Hydrocele 21.95 9.88 35 134095 1918 29438479
Pathogen resistance 21.83 9.88 5 134125 8111 29432286
Poisoning 21.78 9.88 9 134121 9984 29430413
C-reactive protein increased 21.71 9.88 301 133829 43962 29396435
Urticaria 21.59 9.88 152 133978 54508 29385889
Medical device implantation 21.34 9.88 19 134111 556 29439841
Crohn's disease 21.16 9.88 44 134086 2965 29437432
Agitation neonatal 21.10 9.88 25 134105 1031 29439366
Dyslexia 20.99 9.88 15 134115 317 29440080
Substance abuse 20.80 9.88 3 134127 6784 29433613
Heart rate decreased 20.73 9.88 188 133942 24724 29415673
Arthritis bacterial 20.62 9.88 55 134075 4358 29436039
Dyspraxia 20.61 9.88 16 134114 385 29440012
Anal fistula 20.33 9.88 53 134077 4142 29436255
Blood creatine phosphokinase increased 20.26 9.88 105 134025 40539 29399858
Wound 20.17 9.88 108 134022 11955 29428442
Juvenile idiopathic arthritis 19.99 9.88 28 134102 1366 29439031
Attention deficit hyperactivity disorder 19.97 9.88 36 134094 2181 29438216
Patent ductus arteriosus 19.97 9.88 44 134086 3087 29437310
Shock 19.90 9.88 42 134088 21362 29419035
Foetal disorder 19.88 9.88 21 134109 762 29439635
Congenital anomaly 19.53 9.88 27 134103 1301 29439096
Post procedural infection 19.46 9.88 53 134077 4252 29436145
Tuberculosis 19.22 9.88 74 134056 7122 29433275
Vitamin D deficiency 19.21 9.88 62 134068 5467 29434930
Psychomotor retardation 19.18 9.88 42 134088 2934 29437463
Colitis ulcerative 19.14 9.88 111 134019 12658 29427739
Lacrimal disorder 19.07 9.88 14 134116 309 29440088
Bronchiolitis 19.04 9.88 40 134090 2715 29437682
Renal aplasia 18.96 9.88 19 134111 647 29439750
Cleft lip 18.95 9.88 14 134116 312 29440085
Congenital bladder anomaly 18.81 9.88 13 134117 260 29440137
Limb reduction defect 18.76 9.88 13 134117 261 29440136
Acute hepatic failure 18.69 9.88 16 134114 11936 29428461
Weight decrease neonatal 18.69 9.88 14 134116 319 29440078
Renal impairment 18.69 9.88 258 133872 81075 29359322
Malignant melanoma 18.61 9.88 73 134057 7088 29433309
Congenital foot malformation 18.47 9.88 15 134115 386 29440011
Haematocrit decreased 18.37 9.88 207 133923 28815 29411582
Neuroleptic malignant syndrome 18.32 9.88 28 134102 16120 29424277
Blood pressure diastolic increased 18.31 9.88 47 134083 3639 29436758
Toxic epidermal necrolysis 18.27 9.88 34 134096 18119 29422278
Back disorder 18.12 9.88 64 134066 5909 29434488
Intentional self-injury 17.93 9.88 18 134112 12443 29427954
Ankyloglossia congenital 17.82 9.88 13 134117 284 29440113
Scoliosis 17.80 9.88 35 134095 2265 29438132
Nasal disorder 17.73 9.88 27 134103 1422 29438975
Injection site pain 17.72 9.88 225 133905 32221 29408176
Hepatic failure 17.70 9.88 78 134052 31434 29408963
Rash maculo-papular 17.67 9.88 54 134076 24235 29416162
Joint range of motion decreased 17.62 9.88 64 134066 5990 29434407
Diaphragmatic disorder 17.60 9.88 22 134108 960 29439437
Haemangioma congenital 17.56 9.88 16 134114 483 29439914
Joint stiffness 17.36 9.88 87 134043 9386 29431011
Lung neoplasm malignant 17.28 9.88 118 134012 14239 29426158
Inflammation 17.16 9.88 168 133962 22560 29417837
Electrocardiogram QT prolonged 17.10 9.88 95 134035 36042 29404355
Microcephaly 17.09 9.88 19 134111 731 29439666
Umbilical hernia 16.90 9.88 46 134084 3689 29436708
Multiple congenital abnormalities 16.89 9.88 16 134114 508 29439889
Hallucination 16.85 9.88 126 134004 44586 29395811
Bradycardia neonatal 16.75 9.88 21 134109 919 29439478
Arthrodesis 16.73 9.88 15 134115 443 29439954
Respiratory disorder neonatal 16.66 9.88 26 134104 1399 29438998
Weight decreased 16.57 9.88 840 133290 150065 29290332
Vitamin B12 deficiency 16.55 9.88 42 134088 3229 29437168
Grip strength decreased 16.54 9.88 34 134096 2273 29438124
Polydactyly 16.50 9.88 23 134107 1117 29439280
Infective pulmonary exacerbation of cystic fibrosis 16.46 9.88 4 134126 6232 29434165
Proteinuria 16.44 9.88 29 134101 15775 29424622
C-reactive protein decreased 16.35 9.88 27 134103 1524 29438873
Diabetic ketoacidosis 16.27 9.88 30 134100 16043 29424354
Pectus excavatum 16.26 9.88 11 134119 212 29440185
Status epilepticus 16.22 9.88 15 134115 10779 29429618
Spinal disorder 16.21 9.88 45 134085 3650 29436747
Red blood cell sedimentation rate increased 16.21 9.88 72 134058 7389 29433008
Septic arthritis staphylococcal 16.05 9.88 15 134115 468 29439929
Hypertelorism 16.01 9.88 16 134114 543 29439854
Respiratory rate increased 15.97 9.88 80 134050 8628 29431769
Ear disorder 15.96 9.88 24 134106 1250 29439147
Neck mass 15.91 9.88 26 134104 1455 29438942
Haemangioma 15.89 9.88 28 134102 1666 29438731
Cellulitis 15.81 9.88 294 133836 45546 29394851
Pyrexia 15.74 9.88 1108 133022 286514 29153883
Immunodeficiency 15.61 9.88 50 134080 4390 29436007
Ankylosing spondylitis 15.58 9.88 48 134082 4128 29436269
Oesophageal fibrosis 15.57 9.88 10 134120 176 29440221
Therapeutic product effect decreased 15.56 9.88 203 133927 29248 29411149
Infection 15.54 9.88 457 133673 76294 29364103
Poor venous access 15.38 9.88 40 134090 3121 29437276
Contraindicated product administered 15.28 9.88 138 133992 18128 29422269
Maternal exposure timing unspecified 15.17 9.88 13 134117 361 29440036
Neurotoxicity 15.04 9.88 27 134103 14586 29425811
Inguinal hernia 14.88 9.88 65 134065 6623 29433774
No adverse event 14.86 9.88 36 134094 17442 29422955
Arnold-Chiari malformation 14.80 9.88 12 134118 308 29440089
Prostate cancer 14.79 9.88 179 133951 25348 29415049
Emphysema 14.75 9.88 78 134052 8593 29431804
Oropharyngeal pain 14.70 9.88 200 133930 29085 29411312
Pneumonia 14.66 9.88 1662 132468 318510 29121887
Hernia pain 14.52 9.88 11 134119 255 29440142
Foetal distress syndrome 14.23 9.88 20 134110 979 29439418
Injection site bruising 14.16 9.88 70 134060 7510 29432887
Oxygen saturation decreased 14.06 9.88 284 133846 44653 29395744
Blood parathyroid hormone decreased 14.04 9.88 18 134112 806 29439591
Foetal heart rate deceleration abnormality 14.01 9.88 14 134116 475 29439922
Vascular insufficiency 13.98 9.88 12 134118 334 29440063
Venoocclusive liver disease 13.87 9.88 7 134123 6910 29433487
Ear infection 13.87 9.88 73 134057 8027 29432370
Pleural fibrosis 13.75 9.88 23 134107 1312 29439085
Diverticular perforation 13.75 9.88 37 134093 2947 29437450
Anal atresia 13.75 9.88 11 134119 277 29440120
Spina bifida 13.74 9.88 12 134118 342 29440055
Peripheral artery thrombosis 13.73 9.88 30 134100 2092 29438305
Unresponsive to stimuli 13.63 9.88 63 134067 25063 29415334
Finger deformity 13.61 9.88 21 134109 1119 29439278
Tooth malformation 13.60 9.88 9 134121 167 29440230
Blood insulin increased 13.60 9.88 12 134118 347 29440050
Radiation inflammation 13.57 9.88 10 134120 222 29440175
Developmental coordination disorder 13.19 9.88 9 134121 176 29440221
Drug ineffective for unapproved indication 13.12 9.88 28 134102 14186 29426211
Cerebral haemorrhage 13.09 9.88 86 134044 31340 29409057
Ear malformation 13.07 9.88 11 134119 298 29440099
Congenital hydronephrosis 13.00 9.88 16 134114 687 29439710
Mouth ulceration 13.00 9.88 86 134044 10269 29430128
Arthritis infective 13.00 9.88 35 134095 2789 29437608
Incorrect route of product administration 12.97 9.88 18 134112 10783 29429614
Haemolysis 12.82 9.88 64 134066 6892 29433505
Palindromic rheumatism 12.77 9.88 9 134121 186 29440211
Respiratory failure 12.76 9.88 339 133791 96792 29343605
Red blood cell sedimentation rate 12.56 9.88 14 134116 540 29439857
Product quality issue 12.54 9.88 34 134096 15861 29424536
Anaphylactic shock 12.54 9.88 26 134104 13310 29427087
Gangrene neonatal 12.52 9.88 9 134121 192 29440205
Hyperammonaemia 12.50 9.88 5 134125 5658 29434739
Stevens-Johnson syndrome 12.49 9.88 36 134094 16461 29423936
Kidney infection 12.38 9.88 48 134082 4635 29435762
Neonatal seizure 12.32 9.88 13 134117 471 29439926
Excessive cerumen production 12.29 9.88 10 134120 258 29440139
Pulmonary artery stenosis congenital 12.27 9.88 13 134117 473 29439924
Neonatal infection 12.16 9.88 12 134118 401 29439996
Lung cancer metastatic 12.11 9.88 31 134099 2396 29438001
Progressive multifocal leukoencephalopathy 12.08 9.88 13 134117 8706 29431691
Meningeal disorder 12.07 9.88 11 134119 332 29440065
Lipase increased 12.04 9.88 12 134118 8325 29432072
Cleft palate 11.96 9.88 14 134116 570 29439827
Nephrolithiasis 11.90 9.88 171 133959 25163 29415234
Non-Hodgkin's lymphoma 11.85 9.88 23 134107 1474 29438923
Neck pain 11.82 9.88 149 133981 21298 29419099
Osteonecrosis of jaw 11.80 9.88 37 134093 16473 29423924
Back pain 11.76 9.88 572 133558 101712 29338685
Irritability 11.74 9.88 56 134074 22096 29418301
Second primary malignancy 11.73 9.88 8 134122 6697 29433700
Hepatic enzyme increased 11.73 9.88 217 133913 33582 29406815
Cardiogenic shock 11.71 9.88 46 134084 19144 29421253
Aggression 11.63 9.88 104 134026 35437 29404960
Low set ears 11.59 9.88 12 134118 425 29439972
Steatorrhoea 11.57 9.88 15 134115 679 29439718
Malignant neoplasm progression 11.56 9.88 251 133879 73608 29366789
Vomiting 11.54 9.88 818 133312 211442 29228955
Sexual dysfunction 11.49 9.88 6 134124 5808 29434589
Educational problem 11.41 9.88 13 134117 514 29439883
Aspergillus infection 11.39 9.88 19 134111 10562 29429835
Synovial cyst 11.36 9.88 26 134104 1871 29438526
Cholelithiasis 11.28 9.88 132 133998 18540 29421857
Fine motor skill dysfunction 11.28 9.88 23 134107 1528 29438869
Wrong technique in product usage process 11.17 9.88 90 134040 31338 29409059
Foetal hypokinesia 11.16 9.88 11 134119 367 29440030
Decreased appetite 11.14 9.88 542 133588 144800 29295597
Lung neoplasm 11.08 9.88 44 134086 4296 29436101
Pharyngeal disorder 10.98 9.88 14 134116 623 29439774
Dermatitis psoriasiform 10.92 9.88 19 134111 1119 29439278
Tonsil cancer 10.90 9.88 17 134113 914 29439483
Localised infection 10.86 9.88 103 134027 13713 29426684
Abnormal behaviour 10.83 9.88 61 134069 23066 29417331
Oesophageal atresia 10.81 9.88 12 134118 461 29439936
Pancreatic duct stenosis 10.80 9.88 8 134122 179 29440218
Granuloma skin 10.79 9.88 14 134116 634 29439763
Acute chest syndrome 10.73 9.88 10 134120 311 29440086
Sinusitis 10.72 9.88 217 133913 34133 29406264
Joint instability 10.66 9.88 11 134119 388 29440009
Skin lesion 10.66 9.88 130 134000 18442 29421955
Moaning 10.64 9.88 15 134115 736 29439661
Neutropenia neonatal 10.64 9.88 14 134116 643 29439754
Chronic obstructive pulmonary disease 10.64 9.88 252 133878 40703 29399694
Hypoxia 10.62 9.88 151 133979 47228 29393169
Mean cell volume increased 10.61 9.88 30 134100 2459 29437938
Maternal exposure before pregnancy 10.58 9.88 12 134118 472 29439925
Nose deformity 10.54 9.88 8 134122 186 29440211
Hypertriglyceridaemia 10.52 9.88 11 134119 7464 29432933
Hepatocellular injury 10.52 9.88 55 134075 21188 29419209
Dysgeusia 10.52 9.88 60 134070 22614 29417783
Tachycardia 10.51 9.88 249 133881 72161 29368236
Agranulocytosis 10.45 9.88 52 134078 20288 29420109
Pulmonary tuberculosis 10.42 9.88 43 134087 4272 29436125
Transfusion-related circulatory overload 10.36 9.88 8 134122 191 29440206
Mesothelioma 10.35 9.88 11 134119 402 29439995
Retinopathy hypertensive 10.32 9.88 9 134121 256 29440141
Psychomotor skills impaired 10.32 9.88 31 134099 2630 29437767
Disseminated intravascular coagulation 10.31 9.88 51 134079 19929 29420468
Skin graft failure 10.26 9.88 7 134123 137 29440260
Congenital diaphragmatic hernia 10.18 9.88 9 134121 261 29440136
Obsessive-compulsive disorder 10.17 9.88 4 134126 4572 29435825
Necrotising fasciitis streptococcal 10.17 9.88 7 134123 139 29440258
Myoclonus 10.11 9.88 29 134101 13280 29427117
Mucosal ulceration 10.10 9.88 16 134114 872 29439525
Glycosylated haemoglobin increased 10.08 9.88 17 134113 9409 29430988
Hypermetropia 10.07 9.88 11 134119 415 29439982
Gross motor delay 10.06 9.88 9 134121 265 29440132
Placental insufficiency 10.06 9.88 6 134124 92 29440305
Pharyngitis 10.01 9.88 60 134070 6923 29433474
Pyelocaliectasis 9.98 9.88 18 134112 1091 29439306
Blood test abnormal 9.97 9.88 52 134078 5697 29434700
Appendix disorder 9.95 9.88 13 134117 593 29439804
Injection site swelling 9.94 9.88 75 134055 9342 29431055
Heart rate irregular 9.92 9.88 97 134033 13020 29427377
Folate deficiency 9.89 9.88 18 134112 1099 29439298
Respiratory depression 9.88 9.88 30 134100 13493 29426904

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1304.84 10.01 2942 376441 161352 63957997
Completed suicide 872.23 10.01 138 379245 224276 63895073
Pemphigus 837.39 10.01 1375 378008 59326 64060023
Arthropathy 829.98 10.01 2047 377336 118920 64000429
Systemic lupus erythematosus 812.62 10.01 1558 377825 76054 64043295
Joint swelling 806.48 10.01 2941 376442 212441 63906908
Hand deformity 775.92 10.01 1354 378029 61417 64057932
Synovitis 755.37 10.01 1747 377636 97343 64022006
Toxicity to various agents 720.73 10.01 647 378736 362866 63756483
Glossodynia 706.00 10.01 1322 378061 63374 64055975
Arthralgia 690.97 10.01 4706 374677 437554 63681795
Maternal exposure during pregnancy 652.68 10.01 1618 377765 94266 64025083
Infusion related reaction 626.39 10.01 2259 377124 162208 63957141
Drug abuse 606.05 10.01 45 379338 132329 63987020
Anti-cyclic citrullinated peptide antibody positive 583.93 10.01 1047 378336 48515 64070834
Wound 571.36 10.01 1338 378045 75139 64044210
Pericarditis 550.45 10.01 1168 378215 61348 64058001
Pain 506.54 10.01 5223 374160 548288 63571061
Abdominal discomfort 467.95 10.01 2218 377165 180104 63939245
Alopecia 437.10 10.01 2032 377351 163658 63955691
Swelling 410.96 10.01 1949 377434 158269 63961080
Therapeutic product effect decreased 407.52 10.01 1547 377836 113804 64005545
Contraindicated product administered 405.04 10.01 1475 377908 106354 64012995
Nasopharyngitis 402.55 10.01 2241 377142 193832 63925517
Discomfort 390.42 10.01 1204 378179 79674 64039675
Drug interaction 384.63 10.01 988 378395 361095 63758254
Rheumatoid factor positive 349.13 10.01 688 378695 34250 64085099
Drug intolerance 342.49 10.01 2082 377301 185910 63933439
Death 341.83 10.01 1569 377814 481136 63638213
Duodenal ulcer perforation 337.77 10.01 675 378708 33950 64085399
Helicobacter infection 336.74 10.01 716 378667 37646 64081703
Exposure during pregnancy 334.56 10.01 1112 378271 76563 64042786
Musculoskeletal stiffness 312.32 10.01 1494 377889 121712 63997637
Hepatic enzyme increased 305.36 10.01 1542 377841 128401 63990948
Intentional overdose 300.09 10.01 79 379304 89865 64029484
Acute kidney injury 263.97 10.01 1556 377827 447684 63671665
Psoriatic arthropathy 253.81 10.01 691 378692 42590 64076759
C-reactive protein abnormal 246.71 10.01 535 378848 28512 64090837
Sinusitis 230.99 10.01 1560 377823 144368 63974981
Impaired healing 225.90 10.01 826 378557 59647 64059702
Febrile neutropenia 225.44 10.01 479 378904 187178 63932171
Overdose 216.30 10.01 379 379004 159187 63960162
Lower respiratory tract infection 207.09 10.01 1101 378282 93513 64025836
Product use issue 202.62 10.01 1557 377826 150158 63969191
Red blood cell sedimentation rate abnormal 199.07 10.01 350 379033 15956 64103393
Peripheral swelling 198.53 10.01 1991 377392 207162 63912187
Cardiac arrest 195.45 10.01 381 379002 153683 63965666
Hypersensitivity 194.67 10.01 1887 377496 194565 63924784
Treatment failure 190.96 10.01 1259 378124 115557 64003792
Blood pressure fluctuation 184.12 10.01 697 378686 51174 64068175
Muscle injury 183.78 10.01 450 378933 25987 64093362
Depressed level of consciousness 178.32 10.01 131 379252 81305 64038044
Arthritis 175.07 10.01 963 378420 82851 64036498
Drug ineffective 173.63 10.01 6299 373084 833948 63285401
Sickle cell anaemia with crisis 172.95 10.01 184 379199 5148 64114201
Folliculitis 168.21 10.01 472 378911 29605 64089744
Suicide attempt 167.82 10.01 105 379278 70902 64048447
Sleep disorder due to general medical condition, insomnia type 162.66 10.01 428 378955 25842 64093507
Hip arthroplasty 160.89 10.01 375 379008 20976 64098373
Knee arthroplasty 160.22 10.01 433 378950 26566 64092783
Irritable bowel syndrome 159.94 10.01 534 378849 36835 64082514
Bradycardia 158.18 10.01 283 379100 117936 64001413
Weight increased 149.44 10.01 1914 377469 211434 63907915
Psoriasis 146.50 10.01 819 378564 70884 64048465
Drug reaction with eosinophilia and systemic symptoms 144.36 10.01 69 379314 54148 64065201
Respiratory arrest 143.29 10.01 66 379317 52919 64066430
Pregnancy 142.74 10.01 353 379030 20512 64098837
Rhabdomyolysis 138.25 10.01 203 379180 91523 64027826
Blister 136.77 10.01 880 378503 80087 64039262
Osteoarthritis 134.45 10.01 731 378652 62605 64056744
Abortion spontaneous 133.24 10.01 387 378996 24756 64094593
Lactic acidosis 131.60 10.01 101 379282 61309 64058040
Cardiac failure 130.60 10.01 374 379009 131999 63987350
Renal failure 127.90 10.01 591 378792 181097 63938252
Injection site erythema 124.84 10.01 778 378605 70022 64049327
Sedation 122.88 10.01 45 379338 41417 64077932
Infection 122.48 10.01 1642 377741 183238 63936111
Hepatic function abnormal 121.75 10.01 119 379264 64194 64055155
Sopor 117.92 10.01 17 379366 29644 64089705
Malignant neoplasm progression 117.23 10.01 311 379072 112560 64006789
Ill-defined disorder 110.64 10.01 533 378850 43519 64075830
Disease progression 110.00 10.01 444 378939 141236 63978113
Red blood cell sedimentation rate increased 109.41 10.01 418 378965 30817 64088532
Enthesopathy 107.60 10.01 199 379184 9439 64109910
Contusion 106.12 10.01 1081 378302 112884 64006465
Serotonin syndrome 106.11 10.01 49 379334 39233 64080116
Constipation 105.79 10.01 852 378531 228485 63890864
Blood pressure systolic increased 105.11 10.01 571 378812 48882 64070467
Injection site pruritus 101.82 10.01 467 378916 37359 64081990
Injection site pain 99.59 10.01 1048 378335 110360 64008989
Hypoglycaemia 99.29 10.01 240 379143 89652 64029697
Neutropenia 97.75 10.01 919 378464 238705 63880644
Drug resistance 97.62 10.01 42 379341 35060 64084289
Hyponatraemia 97.13 10.01 495 378888 147844 63971505
Fatigue 96.60 10.01 5352 374031 743378 63375971
Joint effusion 95.41 10.01 231 379152 13242 64106107
Agitation 95.19 10.01 239 379144 88128 64031221
Hypotension 95.15 10.01 1622 377761 379352 63739997
Respiratory failure 93.97 10.01 559 378824 160624 63958725
Multiple organ dysfunction syndrome 93.92 10.01 295 379088 101118 64018231
Condition aggravated 93.53 10.01 2859 376524 369567 63749782
Blood pressure diastolic abnormal 92.75 10.01 212 379171 11705 64107644
Juvenile idiopathic arthritis 92.22 10.01 114 379269 3765 64115584
Hepatic failure 92.17 10.01 114 379269 55280 64064069
Cytomegalovirus infection 92.12 10.01 52 379331 37147 64082202
Live birth 91.31 10.01 203 379180 11001 64108348
Drug dependence 90.84 10.01 41 379342 33271 64086078
Blood pressure systolic abnormal 88.88 10.01 187 379196 9755 64109594
Osteoporosis 88.17 10.01 484 378899 41596 64077753
Renal impairment 87.57 10.01 452 378931 134565 63984784
Pain in extremity 87.45 10.01 2368 377015 300717 63818632
Product use in unapproved indication 87.12 10.01 644 378739 175974 63943375
Hyperglycaemia 86.99 10.01 140 379243 60828 64058521
Rheumatic fever 86.82 10.01 178 379205 9116 64110233
Coma 86.79 10.01 247 379136 87368 64031981
Rash 86.57 10.01 3406 375977 455143 63664206
Intentional product misuse 86.34 10.01 185 379198 72110 64047239
Injection site reaction 85.54 10.01 518 378865 46146 64073203
Rheumatoid nodule 85.44 10.01 213 379170 12438 64106911
Somnolence 83.90 10.01 779 378604 202866 63916483
Disability assessment scale score increased 83.28 10.01 88 379295 2442 64116907
Cardio-respiratory arrest 83.05 10.01 298 379085 98095 64021254
Injection site swelling 81.58 10.01 468 378915 40885 64078464
Musculoskeletal pain 80.95 10.01 782 378601 80512 64038837
Tenosynovitis 80.73 10.01 200 379183 11633 64107716
Fibromyalgia 80.32 10.01 419 378964 35312 64084037
Swollen joint count increased 79.93 10.01 154 379229 7535 64111814
Electrocardiogram QT prolonged 79.41 10.01 223 379160 79225 64040124
Blood pressure diastolic decreased 79.39 10.01 300 379083 22001 64097348
Grip strength decreased 78.77 10.01 197 379186 11527 64107822
Caesarean section 77.39 10.01 191 379192 11083 64108266
Intentional self-injury 77.26 10.01 37 379346 29007 64090342
Foot deformity 74.34 10.01 240 379143 16264 64103085
Palmar-plantar erythrodysaesthesia syndrome 73.23 10.01 39 379344 28780 64090569
Heart rate decreased 71.67 10.01 562 378821 54505 64064844
Poisoning 71.47 10.01 20 379363 21859 64097490
Blood pressure increased 71.02 10.01 1417 377966 171135 63948214
Hypoxia 70.46 10.01 273 379110 87876 64031473
Joint laxity 70.05 10.01 77 379306 2237 64117112
Device expulsion 69.65 10.01 19 379364 21117 64098232
Disseminated intravascular coagulation 69.55 10.01 53 379330 32295 64087054
Drug withdrawal syndrome 68.92 10.01 50 379333 31241 64088108
C-reactive protein increased 68.70 10.01 857 378526 94052 64025297
Joint stiffness 68.66 10.01 357 379026 30047 64089302
Delirium 67.84 10.01 196 379187 68998 64050351
Tachycardia 67.41 10.01 559 378824 149020 63970329
Localised infection 67.32 10.01 353 379030 29808 64089541
Inflammation 65.42 10.01 629 378754 64671 64054678
Neoplasm progression 65.36 10.01 87 379296 40877 64078472
Altered state of consciousness 65.18 10.01 76 379307 37826 64081523
Encephalopathy 64.97 10.01 157 379226 58662 64060687
Gastrointestinal disorder 64.91 10.01 810 378573 88899 64030450
Shock 64.35 10.01 78 379305 38162 64081187
Injection site bruising 64.29 10.01 400 378983 35973 64083376
Loss of personal independence in daily activities 63.98 10.01 680 378703 71774 64047575
Bone erosion 62.91 10.01 180 379203 11415 64107934
Respiratory depression 62.15 10.01 30 379353 23413 64095936
Basal cell carcinoma 62.14 10.01 351 379032 30487 64088862
Polyarthritis 60.87 10.01 159 379224 9556 64109793
Immune reconstitution inflammatory syndrome 60.77 10.01 3 379380 12467 64106882
Gestational diabetes 60.63 10.01 114 379269 5476 64113873
Thrombocytopenia 59.68 10.01 941 378442 222860 63896489
Femur fracture 58.84 10.01 373 379010 33762 64085587
Tongue disorder 58.38 10.01 180 379203 11900 64107449
Blood creatine phosphokinase increased 58.05 10.01 165 379218 58393 64060956
Syncope 57.81 10.01 620 378763 157015 63962334
Neuropathy peripheral 57.70 10.01 429 378954 117096 64002253
Metabolic acidosis 57.19 10.01 219 379164 70739 64048610
Cardiac failure congestive 57.03 10.01 492 378891 130088 63989261
Cholestasis 56.82 10.01 111 379272 44761 64074588
Oropharyngeal pain 56.62 10.01 784 378599 88083 64031266
Mydriasis 55.95 10.01 11 379372 15301 64104048
Blood pressure diastolic increased 55.53 10.01 164 379219 10588 64108761
Angioedema 55.02 10.01 183 379200 61638 64057711
Anaemia 54.13 10.01 1756 377627 376924 63742425
Cognitive disorder 54.03 10.01 156 379227 54931 64064418
Stomatitis 53.74 10.01 925 378458 108680 64010669
Cerebral haemorrhage 53.61 10.01 140 379243 50950 64068399
Diabetic ketoacidosis 53.33 10.01 58 379325 29787 64089562
Tendonitis 52.81 10.01 248 379135 20034 64099315
Tremor 52.76 10.01 587 378796 147643 63971706
Hyperhidrosis 52.65 10.01 475 378908 124445 63994904
Hepatocellular injury 52.16 10.01 118 379265 45117 64074232
Acute hepatic failure 52.15 10.01 46 379337 26066 64093283
Premature delivery 51.89 10.01 232 379151 18357 64100992
Body temperature decreased 51.50 10.01 294 379089 25634 64093715
Injection site rash 50.54 10.01 205 379178 15537 64103812
Nodule 50.10 10.01 224 379159 17723 64101626
Pulmonary fibrosis 49.97 10.01 324 379059 29554 64089795
Disturbance in attention 49.96 10.01 104 379279 40970 64078379
Hallucination 49.85 10.01 239 379144 72549 64046800
Hypothermia 48.81 10.01 28 379355 19828 64099521
Vomiting 48.77 10.01 2698 376685 548419 63570930
Neuroleptic malignant syndrome 48.76 10.01 45 379338 24951 64094398
Herpes zoster 47.40 10.01 691 378692 78496 64040853
Synovial cyst 47.13 10.01 125 379258 7582 64111767
Tenderness 46.94 10.01 234 379149 19368 64099981
Joint destruction 46.93 10.01 80 379303 3556 64115793
Pre-eclampsia 46.46 10.01 109 379274 6122 64113227
Fracture 46.42 10.01 226 379157 18529 64100820
Sedation complication 46.02 10.01 4 379379 10350 64108999
Hyperkalaemia 45.97 10.01 377 379006 100752 64018597
Maternal exposure before pregnancy 45.44 10.01 77 379306 3406 64115943
Neck deformity 45.09 10.01 53 379330 1659 64117690
Myalgia 44.63 10.01 660 378723 157957 63961392
Abnormal behaviour 44.48 10.01 81 379302 33541 64085808
Disability 44.37 10.01 165 379218 12007 64107342
Infective pulmonary exacerbation of cystic fibrosis 44.11 10.01 8 379375 11788 64107561
Brain oedema 43.95 10.01 39 379344 22036 64097313
Joint range of motion decreased 43.59 10.01 227 379156 19116 64100233
Mental status changes 43.55 10.01 198 379185 60964 64058385
Hypokalaemia 43.27 10.01 483 378900 121420 63997929
Red blood cell sedimentation rate 43.12 10.01 78 379305 3636 64115713
Anxiety 42.97 10.01 887 378496 201762 63917587
Speech disorder 42.69 10.01 144 379239 48297 64071052
Asthenia 42.68 10.01 2070 377313 425974 63693375
Restlessness 42.53 10.01 108 379275 39677 64079672
Myoclonus 42.51 10.01 51 379332 25067 64094282
Alanine aminotransferase abnormal 42.41 10.01 112 379271 6776 64112573
Ventricular tachycardia 42.32 10.01 86 379297 34179 64085170
Joint injury 42.22 10.01 255 379128 22692 64096657
Myocardial infarction 41.93 10.01 704 378679 165117 63954232
Premature rupture of membranes 41.41 10.01 77 379306 3667 64115682
Seizure 41.41 10.01 711 378672 166181 63953168
Skin ulcer 41.32 10.01 418 378965 43556 64075793
Premature labour 41.05 10.01 118 379265 7502 64111847
Neurotoxicity 40.93 10.01 61 379322 27343 64092006
Limb deformity 40.84 10.01 72 379311 3289 64116060
Disorientation 40.80 10.01 179 379204 55649 64063700
Irritability 40.65 10.01 98 379285 36648 64082701
Laryngitis 40.60 10.01 150 379233 10881 64108468
Orthostatic hypotension 40.46 10.01 140 379243 46598 64072751
Unresponsive to stimuli 40.30 10.01 156 379227 50237 64069112
Poor venous access 40.10 10.01 162 379221 12255 64107094
Dizziness 40.04 10.01 2095 377288 428068 63691281
Dyspnoea 39.88 10.01 3663 375720 715011 63404338
Neck mass 39.62 10.01 79 379304 3965 64115384
Bronchitis 39.50 10.01 877 378506 107866 64011483
Diarrhoea 39.46 10.01 3688 375695 719016 63400333
Respiratory distress 39.33 10.01 166 379217 52165 64067184
Multiple sclerosis relapse 39.24 10.01 118 379265 41017 64078332
Venoocclusive liver disease 39.21 10.01 6 379377 10009 64109340
Tuberculosis 38.89 10.01 166 379217 12872 64106477
Cytokine release syndrome 38.88 10.01 39 379344 20790 64098559
Dehydration 38.83 10.01 974 378409 215789 63903560
Leukopenia 38.81 10.01 394 378989 100848 64018501
Oral herpes 38.76 10.01 243 379140 21909 64097440
Ventricular fibrillation 38.75 10.01 50 379333 23810 64095539
Smear cervix abnormal 38.56 10.01 58 379325 2316 64117033
Anaphylactic shock 38.42 10.01 75 379308 30253 64089096
Posterior reversible encephalopathy syndrome 38.40 10.01 47 379336 22899 64096450
Neutrophil count decreased 38.26 10.01 281 379102 76915 64042434
Decreased appetite 38.12 10.01 1313 378070 279976 63839373
Arthritis infective 38.01 10.01 109 379274 6921 64112428
Blood glucose increased 37.87 10.01 381 379002 97692 64021657
Influenza 37.70 10.01 856 378527 105675 64013674
Substance abuse 37.70 10.01 5 379378 9287 64110062
Pulmonary arterial hypertension 37.37 10.01 57 379326 25310 64094039
Ejection fraction decreased 37.23 10.01 70 379313 28637 64090712
Bone disorder 36.61 10.01 195 379188 16564 64102785
Pulmonary embolism 36.47 10.01 623 378760 145733 63973616
Cardiogenic shock 36.25 10.01 86 379297 32341 64087008
Extrapyramidal disorder 36.05 10.01 37 379346 19515 64099834
Latent tuberculosis 36.03 10.01 61 379322 2696 64116653
Spinal stenosis 36.02 10.01 170 379213 13761 64105588
Melaena 35.99 10.01 177 379206 53371 64065978
Multiple fractures 35.96 10.01 97 379286 5943 64113406
Status epilepticus 35.59 10.01 45 379338 21618 64097731
Urticaria 35.45 10.01 631 378752 146686 63972663
Psychotic disorder 35.33 10.01 96 379287 34482 64084867
Fear of injection 35.25 10.01 95 379288 5817 64113532
Aggression 35.15 10.01 146 379237 46086 64073263
Blood creatinine increased 35.14 10.01 574 378809 135208 63984141
Therapeutic response decreased 35.11 10.01 465 378918 51723 64067626
Fluid retention 35.09 10.01 206 379177 59400 64059949
Suicidal ideation 35.04 10.01 238 379145 66304 64053045
Drug level increased 34.89 10.01 95 379288 34101 64085248
Pathogen resistance 34.89 10.01 15 379368 12528 64106821
Immunodeficiency 34.81 10.01 187 379196 15937 64103412
Psychomotor hyperactivity 34.65 10.01 21 379362 14430 64104919
Skin cancer 34.60 10.01 151 379232 11823 64107526
Accidental overdose 34.41 10.01 93 379290 33464 64085885
Nausea 34.26 10.01 4074 375309 781726 63337623
Torsade de pointes 34.18 10.01 31 379352 17332 64102017
Product quality issue 34.14 10.01 78 379305 29721 64089628
Wheelchair user 34.04 10.01 81 379302 4591 64114758
Ascites 34.03 10.01 219 379164 61782 64057567
Pancytopenia 33.97 10.01 1093 378290 142216 63977133
Second primary malignancy 33.92 10.01 15 379368 12322 64107027
Inappropriate antidiuretic hormone secretion 33.89 10.01 49 379334 22240 64097109
Aspergillus infection 33.75 10.01 28 379355 16351 64102998
Mouth ulceration 33.72 10.01 315 379068 32129 64087220
Rash maculo-papular 33.62 10.01 152 379231 46874 64072475
Cerebral infarction 33.51 10.01 126 379257 40918 64078431
Surgery 33.49 10.01 282 379101 27931 64091418
Tenosynovitis stenosans 33.43 10.01 49 379334 1911 64117438
Arrhythmia 33.32 10.01 179 379204 52765 64066584
Proteinuria 33.04 10.01 71 379312 27652 64091697
Ear infection 32.76 10.01 243 379140 23161 64096188
Gastrointestinal haemorrhage 32.71 10.01 564 378819 131748 63987601
Asphyxia 32.67 10.01 8 379375 9558 64109791
Skin papilloma 32.44 10.01 85 379298 5118 64114231
Blood cholesterol increased 32.41 10.01 443 378940 49623 64069726
Agranulocytosis 32.10 10.01 116 379267 38113 64081236
Bradyphrenia 31.86 10.01 8 379375 9398 64109951
Gastroenteritis viral 31.81 10.01 212 379171 19517 64099832
Atrial fibrillation 31.66 10.01 765 378618 170324 63949025
Drug ineffective for unapproved indication 31.39 10.01 87 379296 31046 64088303
Malignant melanoma 31.21 10.01 155 379228 12809 64106540
Balance disorder 31.19 10.01 329 379054 83597 64035752
Bronchopulmonary aspergillosis 30.99 10.01 40 379343 19045 64100304
No adverse event 30.94 10.01 77 379306 28484 64090865
Intentional product use issue 30.90 10.01 757 378626 94607 64024742
Ischaemic stroke 30.89 10.01 79 379304 28956 64090393
Transplant rejection 30.89 10.01 34 379349 17367 64101982
Withdrawal syndrome 30.72 10.01 57 379326 23435 64095914
Joint noise 30.59 10.01 62 379321 3149 64116200
Haematotoxicity 30.56 10.01 19 379364 12877 64106472
Product administration error 30.35 10.01 74 379309 27569 64091780
Injection site warmth 30.34 10.01 158 379225 13304 64106045
Akathisia 30.10 10.01 15 379368 11495 64107854
Emotional distress 29.83 10.01 110 379273 35928 64083421
Foot fracture 29.81 10.01 196 379187 17961 64101388
Vision blurred 29.66 10.01 364 379019 89952 64029397
Mobility decreased 29.52 10.01 687 378696 85153 64034196
Miosis 29.47 10.01 21 379362 13245 64106104
Synovial fluid analysis 29.37 10.01 41 379342 1528 64117821
Asthma 29.34 10.01 389 378994 94836 64024513
Rotator cuff repair 29.31 10.01 40 379343 1459 64117890
Tachypnoea 29.28 10.01 71 379312 26500 64092849
Gamma-glutamyltransferase increased 28.90 10.01 167 379216 48343 64071006
Unintentional medical device removal 28.87 10.01 3 379380 6731 64112618
Blood parathyroid hormone decreased 28.66 10.01 102 379281 7264 64112085
Acute respiratory failure 28.64 10.01 174 379209 49760 64069589
Shock haemorrhagic 28.51 10.01 34 379349 16757 64102592
Ulcer 28.47 10.01 232 379151 22758 64096591
Acute graft versus host disease 28.40 10.01 9 379374 9075 64110274
Foetal death 28.32 10.01 88 379295 5842 64113507
Coagulopathy 28.05 10.01 95 379288 31825 64087524
Rhinorrhoea 27.91 10.01 502 378881 59467 64059882
Maternal exposure timing unspecified 27.87 10.01 54 379329 2653 64116696
Subdural haematoma 27.83 10.01 79 379304 27975 64091374
BK virus infection 27.77 10.01 5 379378 7407 64111942
Loose body in joint 27.68 10.01 35 379348 1183 64118166
Coronary artery disease 27.59 10.01 225 379158 60208 64059141
Tumour lysis syndrome 27.39 10.01 45 379338 19395 64099954
Eosinophilia 27.26 10.01 123 379260 37953 64081396
Forced expiratory volume decreased 27.14 10.01 4 379379 6863 64112486
Muscle spasms 27.07 10.01 627 378756 140396 63978953
Haemoptysis 27.05 10.01 173 379210 48875 64070474
Pulmonary oedema 27.02 10.01 314 379069 78360 64040989
Acute chest syndrome 26.90 10.01 30 379353 886 64118463
Loss of consciousness 26.73 10.01 666 378717 147699 63971650
Hypertransaminasaemia 26.62 10.01 5 379378 7186 64112163
Oxygen saturation decreased 26.59 10.01 822 378561 106354 64012995
Osteonecrosis of jaw 26.55 10.01 132 379251 39693 64079656
Anaphylactic reaction 26.40 10.01 267 379116 68397 64050952
Fear 26.32 10.01 49 379334 20122 64099227
Dystonia 26.27 10.01 44 379339 18821 64100528
Respiratory disorder 26.25 10.01 116 379267 35995 64083354
Post procedural infection 26.20 10.01 119 379264 9478 64109871
Haemorrhage intracranial 26.18 10.01 64 379319 23820 64095529
Blood alkaline phosphatase increased 25.94 10.01 209 379174 56070 64063279
Thrombotic microangiopathy 25.93 10.01 36 379347 16619 64102730
Dysarthria 25.85 10.01 224 379159 59182 64060167
Chronic kidney disease 25.82 10.01 217 379166 57702 64061647
Graft versus host disease 25.63 10.01 26 379357 13787 64105562
Antinuclear antibody positive 25.58 10.01 88 379295 6162 64113187
Erythema multiforme 25.40 10.01 33 379350 15668 64103681
Postoperative wound infection 25.18 10.01 124 379259 10212 64109137
Blood bilirubin increased 25.05 10.01 217 379166 57336 64062013
Toxic skin eruption 25.03 10.01 47 379336 19237 64100112
Sepsis 24.89 10.01 1104 378279 229237 63890112
Toxic epidermal necrolysis 24.89 10.01 123 379260 37043 64082306
Hyperthermia 24.83 10.01 33 379350 15517 64103832
Fracture delayed union 24.74 10.01 43 379340 1942 64117407
Creatinine renal clearance decreased 24.70 10.01 29 379354 14392 64104957
Leukocytosis 24.64 10.01 126 379257 37614 64081735
Clostridium difficile colitis 24.62 10.01 80 379303 27143 64092206
Mania 24.57 10.01 36 379347 16250 64103099
Cerebrovascular accident 24.41 10.01 619 378764 136964 63982385
Dysgeusia 24.41 10.01 169 379214 46878 64072471
Granuloma skin 24.40 10.01 85 379298 5989 64113360
Panniculitis 24.17 10.01 110 379273 8769 64110580
Haemorrhage 24.14 10.01 325 379058 79026 64040323
Pleural effusion 23.93 10.01 564 378819 125995 63993354
Deep vein thrombosis 23.90 10.01 455 378928 104727 64014622
Acute respiratory distress syndrome 23.75 10.01 133 379250 38802 64080547
Polyhydramnios 23.68 10.01 36 379347 1451 64117898
Glycosylated haemoglobin increased 23.59 10.01 36 379347 15983 64103366
Scleritis 23.34 10.01 53 379330 2913 64116436
Acute generalised exanthematous pustulosis 23.31 10.01 29 379354 14029 64105320
White blood cell count decreased 23.19 10.01 729 378654 157108 63962241
Drug hypersensitivity 23.07 10.01 1153 378230 236662 63882687
Face oedema 22.93 10.01 72 379311 24689 64094660
Drug use disorder 22.87 10.01 4 379379 6050 64113299
Joint dislocation 22.77 10.01 130 379253 11335 64108014
Stevens-Johnson syndrome 22.56 10.01 114 379269 34135 64085214
Acidosis 22.54 10.01 44 379339 17751 64101598
Jaundice 22.43 10.01 180 379203 48332 64071017
Hyperbilirubinaemia 22.32 10.01 58 379325 21147 64098202
Stillbirth 22.29 10.01 59 379324 3574 64115775
Adverse event 22.22 10.01 341 379042 39148 64080201
Pyrexia 22.20 10.01 2913 376470 555731 63563618
Dyskinesia 22.19 10.01 138 379245 39250 64080099
Hypomagnesaemia 22.09 10.01 129 379254 37247 64082102
Bursitis 22.03 10.01 208 379175 21277 64098072
Platelet count decreased 21.97 10.01 786 378597 166925 63952424
Pharyngitis streptococcal 21.84 10.01 105 379278 8563 64110786
Aphasia 21.68 10.01 146 379237 40760 64078589
Dactylitis 21.61 10.01 40 379343 1898 64117451
Hyperammonaemia 21.58 10.01 16 379367 9888 64109461
Haemoglobin decreased 21.29 10.01 1375 378008 193688 63925661
Vertigo 21.25 10.01 233 379150 58778 64060571
Synovial disorder 21.17 10.01 27 379356 921 64118428
Endodontic procedure 21.12 10.01 44 379339 2279 64117070
Febrile bone marrow aplasia 21.09 10.01 21 379362 11234 64108115
Acute graft versus host disease in skin 21.07 10.01 7 379376 6848 64112501
Cardiac failure acute 21.07 10.01 40 379343 16304 64103045
Wrong technique in product usage process 20.91 10.01 263 379120 64711 64054638
Potentiating drug interaction 20.89 10.01 10 379373 7842 64111507
Pulmonary alveolar haemorrhage 20.88 10.01 16 379367 9722 64109627
Bronchospasm 20.82 10.01 62 379321 21620 64097729
Pancreatitis 20.81 10.01 237 379146 59370 64059979
Cyanosis 20.81 10.01 64 379319 22091 64097258
Pneumatosis intestinalis 20.78 10.01 3 379380 5226 64114123
Breast feeding 20.77 10.01 23 379360 674 64118675
Weight decreased 20.75 10.01 1951 377432 283788 63835561
Pulmonary tuberculosis 20.66 10.01 91 379292 7153 64112196
Lipase increased 20.61 10.01 33 379350 14369 64104980
Normal newborn 20.35 10.01 76 379307 5541 64113808
Hyperuricaemia 20.29 10.01 18 379365 10173 64109176
Pemphigoid 20.29 10.01 28 379355 12958 64106391
Stress cardiomyopathy 20.11 10.01 15 379368 9242 64110107
Depression 20.10 10.01 877 378506 182414 63936935
Incorrect route of product administration 20.02 10.01 70 379313 23228 64096121
Dyspnoea exertional 19.96 10.01 309 379074 73421 64045928
Hallucination, visual 19.88 10.01 90 379293 27744 64091605
Exostosis 19.72 10.01 125 379258 11313 64108036
Lupus-like syndrome 19.69 10.01 103 379280 8688 64110661
Hepatic encephalopathy 19.69 10.01 61 379322 21005 64098344
Adenovirus infection 19.67 10.01 9 379374 7246 64112103
Sinus tachycardia 19.61 10.01 110 379273 32078 64087271
Acute myeloid leukaemia 19.49 10.01 89 379294 27374 64091975
Haemophagocytic lymphohistiocytosis 19.44 10.01 47 379336 17562 64101787
Exposure to toxic agent 19.44 10.01 6 379377 6153 64113196
Human antichimeric antibody positive 19.40 10.01 32 379351 1384 64117965
Endophthalmitis 19.30 10.01 4 379379 5361 64113988
Dermatitis acneiform 19.24 10.01 13 379370 8430 64110919
Device use error 19.21 10.01 7 379376 6464 64112885
Aspartate aminotransferase increased 19.14 10.01 547 378836 119241 64000108
Rebound effect 19.13 10.01 3 379380 4914 64114435
Cushingoid 19.09 10.01 92 379291 7511 64111838
Foetal distress syndrome 19.09 10.01 18 379365 434 64118915
Polyneuropathy 19.02 10.01 57 379326 19837 64099512
Muscle rigidity 19.01 10.01 47 379336 17426 64101923
Haemorrhage in pregnancy 19.00 10.01 30 379353 1250 64118099
Tooth infection 18.98 10.01 149 379234 14452 64104897
Mass 18.83 10.01 154 379229 15122 64104227
Nightmare 18.77 10.01 62 379321 20931 64098418
Induced labour 18.74 10.01 24 379359 822 64118527
Haematocrit decreased 18.66 10.01 437 378946 54218 64065131
Cyst 18.65 10.01 128 379255 11899 64107450
Tardive dyskinesia 18.53 10.01 16 379367 9162 64110187
Metastases to bone 18.52 10.01 60 379323 20375 64098974
Klebsiella infection 18.47 10.01 31 379352 13250 64106099
Respiration abnormal 18.46 10.01 7 379376 6308 64113041
Dry eye 18.46 10.01 256 379127 28763 64090586
Pancreatitis acute 18.46 10.01 162 379221 42693 64076656
Ingrown hair 18.44 10.01 20 379363 572 64118777
Delusion 18.41 10.01 50 379333 17964 64101385
Nocardiosis 18.34 10.01 3 379380 4764 64114585
Cytomegalovirus viraemia 18.31 10.01 22 379361 10806 64108543
Chronic graft versus host disease 18.28 10.01 7 379376 6269 64113080
Placental disorder 18.21 10.01 24 379359 846 64118503
Musculoskeletal disorder 18.18 10.01 173 379210 17733 64101616
Pulmonary hypertension 18.18 10.01 164 379219 42975 64076374
Anhedonia 18.15 10.01 33 379350 13673 64105676
Hallucination, auditory 18.09 10.01 46 379337 16893 64102456
Polyuria 18.06 10.01 29 379354 12614 64106735
Spinal disorder 18.05 10.01 100 379283 8622 64110727
Muscle spasticity 18.01 10.01 45 379338 16624 64102725
Colitis ulcerative 17.98 10.01 211 379172 22817 64096532
Injection site urticaria 17.94 10.01 120 379263 11061 64108288
Angina pectoris 17.87 10.01 174 379209 44907 64074442
Bone pain 17.87 10.01 186 379197 47386 64071963
Labelled drug-drug interaction medication error 17.83 10.01 68 379315 21994 64097355
Lacrimal disorder 17.82 10.01 18 379365 473 64118876
Polydipsia 17.79 10.01 6 379377 5815 64113534
Frequent bowel movements 17.68 10.01 175 379208 18130 64101219
Arthritis bacterial 17.66 10.01 92 379291 7747 64111602
Flushing 17.62 10.01 341 379042 78307 64041042
Progressive multifocal leukoencephalopathy 17.61 10.01 52 379331 18180 64101169
Tubulointerstitial nephritis 17.57 10.01 108 379275 30801 64088548
Pleuritic pain 17.55 10.01 94 379289 8002 64111347
Heart rate irregular 17.51 10.01 242 379141 27171 64092178
Cardiomyopathy 17.51 10.01 83 379300 25273 64094076
Dislocation of vertebra 17.44 10.01 49 379334 3075 64116274
Urinary retention 17.42 10.01 195 379188 49006 64070343
Cellulitis 17.42 10.01 695 378688 92962 64026387
Tooth abscess 17.38 10.01 140 379243 13686 64105663
Cytopenia 17.32 10.01 41 379342 15430 64103919
Bone density abnormal 17.27 10.01 45 379338 2700 64116649
Drug-induced liver injury 17.20 10.01 188 379195 47455 64071894
Body height below normal 17.19 10.01 35 379348 1783 64117566
Cystitis haemorrhagic 17.15 10.01 13 379370 7943 64111406
Pain in jaw 17.14 10.01 155 379228 40600 64078749
Chest discomfort 17.11 10.01 536 378847 115570 64003779
Anuria 16.96 10.01 56 379327 18908 64100441
Upper respiratory tract infection 16.94 10.01 554 378829 72231 64047118
Toothache 16.90 10.01 167 379216 17292 64102057
Oliguria 16.82 10.01 38 379345 14538 64104811
Placental insufficiency 16.68 10.01 25 379358 995 64118354
Gestational hypertension 16.66 10.01 33 379350 1648 64117701
Hyperlactacidaemia 16.64 10.01 4 379379 4840 64114509
Injection site haemorrhage 16.61 10.01 217 379166 24061 64095288
Acute coronary syndrome 16.61 10.01 58 379325 19252 64100097
Affective disorder 16.58 10.01 9 379374 6571 64112778
Device difficult to use 16.47 10.01 20 379363 9778 64109571
Immunosuppression 16.45 10.01 114 379269 10632 64108717
Sinus bradycardia 16.36 10.01 74 379309 22819 64096530
Wound infection pseudomonas 16.30 10.01 31 379352 1502 64117847
Type 2 diabetes mellitus 16.26 10.01 286 379097 33734 64085615
Sexual dysfunction 16.09 10.01 9 379374 6462 64112887
Tooth disorder 16.07 10.01 202 379181 22200 64097149
Insomnia 16.07 10.01 976 378407 196860 63922489
Cystitis 16.07 10.01 346 379037 42329 64077020
Blood pressure decreased 16.05 10.01 385 378998 85814 64033535
Tuberculin test positive 16.04 10.01 47 379336 3021 64116328
International normalised ratio increased 16.03 10.01 349 379034 78818 64040531
Kidney infection 16.01 10.01 168 379215 17670 64101679
Chest pain 16.01 10.01 1183 378200 234797 63884552
Dysphagia 16.01 10.01 492 378891 106320 64013029
Lymphatic fistula 16.00 10.01 21 379362 737 64118612
Femoral hernia incarcerated 15.94 10.01 21 379362 740 64118609
Arthropod bite 15.93 10.01 80 379303 6641 64112708
Metastases to lung 15.88 10.01 42 379341 15222 64104127
Atrioventricular block 15.84 10.01 29 379354 11986 64107363
Maternal exposure during breast feeding 15.84 10.01 36 379347 1980 64117369
Hemiplegia 15.81 10.01 32 379351 12736 64106613
Wound infection 15.79 10.01 145 379238 14719 64104630
Off label use 15.72 10.01 3387 375996 629419 63489930
Epstein-Barr virus infection 15.71 10.01 31 379352 12457 64106892
Pulseless electrical activity 15.71 10.01 32 379351 12707 64106642
Cardiac failure chronic 15.68 10.01 18 379365 9023 64110326
Blood lactic acid increased 15.68 10.01 23 379360 10378 64108971
Gastric haemorrhage 15.67 10.01 35 379348 13446 64105903
Renal injury 15.64 10.01 43 379340 15386 64103963
Metastases to liver 15.59 10.01 80 379303 23861 64095488
Sciatica 15.53 10.01 185 379198 20079 64099270
Coronary arterial stent insertion 15.53 10.01 7 379376 5685 64113664
Atrioventricular block complete 15.51 10.01 39 379344 14379 64104970
Septic shock 15.47 10.01 487 378896 104950 64014399
Cervical incompetence 15.43 10.01 17 379366 495 64118854
Peripheral sensory neuropathy 15.42 10.01 27 379356 11351 64107998
Joint lock 15.41 10.01 44 379339 2787 64116562
Electrocardiogram QRS complex prolonged 15.40 10.01 19 379364 9225 64110124
Obstructive airways disorder 15.37 10.01 77 379306 23108 64096241
Pulmonary haemorrhage 15.27 10.01 34 379349 13075 64106274
Hypoalbuminaemia 15.26 10.01 53 379330 17621 64101728
Hepatitis fulminant 15.21 10.01 9 379374 6265 64113084
Clear cell renal cell carcinoma 15.04 10.01 37 379346 2142 64117207
Injection site discolouration 15.02 10.01 80 379303 6795 64112554
Iodine allergy 15.01 10.01 17 379366 511 64118838
Injection site extravasation 14.96 10.01 90 379293 7996 64111353
Rheumatoid lung 14.95 10.01 40 379343 2439 64116910
Hypophosphataemia 14.94 10.01 41 379342 14679 64104670
Malignant mediastinal neoplasm 14.85 10.01 17 379366 517 64118832
Alcohol abuse 14.83 10.01 5 379378 4847 64114502
Visual acuity reduced 14.82 10.01 96 379287 27045 64092304
Sickle cell anaemia 14.81 10.01 18 379365 584 64118765
Acute myocardial infarction 14.80 10.01 305 379078 69413 64049936
Nephropathy toxic 14.80 10.01 53 379330 17461 64101888
Aphthous ulcer 14.79 10.01 128 379255 12778 64106571
Abortion threatened 14.74 10.01 15 379368 398 64118951
Antibody test positive 14.68 10.01 39 379344 2368 64116981
Pharyngitis 14.67 10.01 174 379209 18865 64100484
Hypervolaemia 14.66 10.01 149 379234 38136 64081213
Haematoma 14.58 10.01 188 379195 46062 64073287
Catatonia 14.53 10.01 14 379369 7606 64111743
Disease recurrence 14.53 10.01 117 379266 31393 64087956
Ankle arthroplasty 14.52 10.01 22 379361 884 64118465
Toxic encephalopathy 14.51 10.01 22 379361 9793 64109556
Red blood cell count decreased 14.46 10.01 380 379003 48006 64071343
Anger 14.41 10.01 46 379337 15695 64103654
Knee operation 14.36 10.01 59 379324 4498 64114851
Joint warmth 14.28 10.01 28 379355 1388 64117961
Cholestasis of pregnancy 14.18 10.01 22 379361 903 64118446
Adjustment disorder with depressed mood 14.17 10.01 39 379344 2418 64116931
Hyperthyroidism 14.07 10.01 57 379326 18122 64101227
Palpitations 14.06 10.01 488 378895 104000 64015349
Tendon disorder 14.05 10.01 74 379309 6258 64113091
Small for dates baby 13.97 10.01 15 379368 424 64118925
Myopathy 13.96 10.01 55 379328 17625 64101724
Eye infection 13.93 10.01 98 379285 9183 64110166
Finger deformity 13.93 10.01 64 379319 5122 64114227
Nephrolithiasis 13.92 10.01 346 379037 43337 64076012
Muscle twitching 13.82 10.01 61 379322 18937 64100412
Hepatitis acute 13.81 10.01 37 379346 13352 64105997
Transaminases increased 13.79 10.01 182 379201 44412 64074937
Pneumothorax 13.76 10.01 85 379298 24213 64095136
Breast abscess 13.73 10.01 24 379359 1089 64118260
Ileus 13.71 10.01 79 379304 22887 64096462
Respiratory acidosis 13.71 10.01 23 379360 9832 64109517
Hypercapnia 13.69 10.01 15 379368 7679 64111670
Human anti-human antibody test 13.68 10.01 14 379369 374 64118975
Palindromic rheumatism 13.66 10.01 13 379370 317 64119032
C-reactive protein decreased 13.63 10.01 35 379348 2081 64117268
Paralysis 13.57 10.01 30 379353 11565 64107784
Temperature regulation disorder 13.48 10.01 4 379379 4207 64115142
Foot operation 13.47 10.01 55 379328 4180 64115169
Myocarditis 13.47 10.01 53 379330 16990 64102359
Cytomegalovirus chorioretinitis 13.46 10.01 6 379377 4906 64114443
Hernia 13.43 10.01 130 379253 13388 64105961
Dyslipidaemia 13.39 10.01 21 379362 9221 64110128
Lymphocyte count decreased 13.37 10.01 164 379219 40535 64078814
Foetal exposure during pregnancy 13.36 10.01 57 379326 4419 64114930
Enterocolitis 13.33 10.01 32 379351 11986 64107363
Bacteraemia 13.31 10.01 98 379285 26813 64092536
Osteoporotic fracture 13.30 10.01 49 379334 3549 64115800
Ileus paralytic 13.29 10.01 18 379365 8397 64110952
Right ventricular failure 13.28 10.01 73 379310 21398 64097951
Pulmonary congestion 13.28 10.01 84 379299 23796 64095553
Pseudomonas infection 13.27 10.01 57 379326 17826 64101523
Presyncope 13.26 10.01 137 379246 34952 64084397
Interstitial lung disease 13.25 10.01 456 378927 97276 64022073
Oesophageal fibrosis 13.22 10.01 10 379373 176 64119173
Delivery 13.21 10.01 16 379367 517 64118832
Product prescribing error 13.20 10.01 138 379245 35131 64084218
Metastases to central nervous system 13.20 10.01 40 379343 13872 64105477
End stage renal disease 13.18 10.01 26 379357 10449 64108900
Hemiparesis 13.18 10.01 112 379271 29715 64089634
Drug abuser 13.16 10.01 9 379374 5799 64113550
Blood calcium decreased 13.15 10.01 92 379291 25462 64093887
Blood loss anaemia 13.14 10.01 40 379343 13852 64105497
Lip swelling 13.14 10.01 122 379261 31785 64087564
Stress at work 13.08 10.01 22 379361 967 64118382
Bradypnoea 13.08 10.01 7 379376 5152 64114197
Serum ferritin increased 13.06 10.01 90 379293 8378 64110971
Hepatitis cholestatic 12.99 10.01 33 379350 12122 64107227
Lung transplant 12.97 10.01 4 379379 4104 64115245
Retinitis 12.93 10.01 34 379349 2051 64117298
Myofascial pain syndrome 12.91 10.01 31 379352 1767 64117582
Increased tendency to bruise 12.90 10.01 96 379287 9159 64110190
Abortion missed 12.83 10.01 24 379359 1148 64118201
Coordination abnormal 12.83 10.01 45 379338 14919 64104430
Drug specific antibody 12.83 10.01 34 379349 2061 64117288
Drug screen positive 12.82 10.01 9 379374 5720 64113629
Anal fistula 12.78 10.01 63 379320 5190 64114159
Pancreatic steatosis 12.78 10.01 22 379361 986 64118363
Blood folate increased 12.75 10.01 15 379368 470 64118879
Feeling abnormal 12.70 10.01 649 378734 132953 63986396
Hypocalcaemia 12.70 10.01 171 379212 41582 64077767
Postpartum haemorrhage 12.68 10.01 27 379356 1420 64117929
Bradykinesia 12.57 10.01 12 379371 6548 64112801
Abdominal distension 12.53 10.01 450 378933 95544 64023805
Incoherent 12.53 10.01 14 379369 7104 64112245
Skin ulcer haemorrhage 12.53 10.01 15 379368 479 64118870
Graft versus host disease in skin 12.50 10.01 8 379375 5339 64114010
Therapy non-responder 12.48 10.01 490 378893 65409 64053940
Threatened labour 12.47 10.01 16 379367 549 64118800
Osteopenia 12.41 10.01 143 379240 15397 64103952
Ankylosing spondylitis 12.39 10.01 87 379296 8147 64111202
Pneumonia bacterial 12.37 10.01 46 379337 14989 64104360
Hypernatraemia 12.33 10.01 34 379349 12155 64107194
Skin laceration 12.29 10.01 207 379176 24210 64095139
Chondropathy 12.29 10.01 36 379347 2313 64117036
Hepatocellular carcinoma 12.26 10.01 19 379364 8384 64110965
Taste disorder 12.23 10.01 23 379360 9410 64109939
Lip blister 12.19 10.01 35 379348 2224 64117125
Plasma cell myeloma 12.17 10.01 194 379189 45881 64073468
Hospitalisation 12.12 10.01 343 379040 74864 64044485
Skin neoplasm excision 12.11 10.01 20 379363 866 64118483
Intracranial pressure increased 12.03 10.01 14 379369 6975 64112374
Hepatotoxicity 12.03 10.01 164 379219 39798 64079551
Transplant dysfunction 12.02 10.01 13 379370 6695 64112654
Oligohydramnios 11.93 10.01 43 379340 3081 64116268
Spinal osteoarthritis 11.92 10.01 133 379250 14208 64105141
Mean cell volume increased 11.91 10.01 60 379323 4986 64114363
Sinus congestion 11.85 10.01 141 379242 15298 64104051
Cholangitis 11.79 10.01 29 379354 10773 64108576
Eosinophil count increased 11.73 10.01 43 379340 14069 64105280
Hepatitis C 11.69 10.01 30 379353 10985 64108364
Labyrinthitis 11.68 10.01 38 379345 2585 64116764
Cardiotoxicity 11.68 10.01 27 379356 10247 64109102
Virologic failure 11.64 10.01 3 379380 3463 64115886
Heparin-induced thrombocytopenia 11.60 10.01 20 379363 8459 64110890
Purpura 11.59 10.01 57 379326 17189 64102160
Swollen joint count 11.55 10.01 16 379367 592 64118757
Hypotonia 11.55 10.01 31 379352 11181 64108168
Sudden death 11.53 10.01 70 379313 20026 64099323
Peritoneal dialysis complication 11.52 10.01 34 379349 2194 64117155
Lower respiratory tract congestion 11.52 10.01 41 379342 2920 64116429
Skin graft failure 11.51 10.01 10 379373 216 64119133
Skin necrosis 11.50 10.01 132 379251 14197 64105152
Erectile dysfunction 11.49 10.01 37 379346 12590 64106759
Vacuum extractor delivery 11.49 10.01 8 379375 123 64119226
Generalised tonic-clonic seizure 11.49 10.01 165 379218 39692 64079657
Mesothelioma 11.44 10.01 12 379371 330 64119019
Alanine aminotransferase increased 11.44 10.01 685 378698 138346 63981003
Schizophrenia 11.41 10.01 31 379352 11137 64108212
Nail injury 11.40 10.01 14 379369 459 64118890
Amylase increased 11.38 10.01 25 379358 9660 64109689
Cataract 11.37 10.01 388 378995 50874 64068475
Sensitivity to weather change 11.34 10.01 73 379310 6641 64112708
Myocardial ischaemia 11.34 10.01 85 379298 23166 64096183
Memory impairment 11.34 10.01 401 378982 85281 64034068
Radiation inflammation 11.28 10.01 10 379373 222 64119127
Unevaluable event 11.28 10.01 219 379164 50270 64069079
Hydrocephalus 11.24 10.01 17 379366 7574 64111775
Myelosuppression 11.21 10.01 88 379295 23742 64095607
Medical device site joint infection 11.17 10.01 10 379373 225 64119124
Drug tolerance decreased 11.16 10.01 75 379308 6923 64112426
Accidental death 11.11 10.01 4 379379 3721 64115628
Intestinal ischaemia 11.11 10.01 33 379350 11516 64107833
Catheter management 11.08 10.01 3 379380 3352 64115997
Haematemesis 11.08 10.01 202 379181 46797 64072552
Neck pain 11.06 10.01 455 378928 61078 64058271
Speech disorder developmental 11.06 10.01 15 379368 544 64118805
Carpal tunnel syndrome 11.05 10.01 142 379241 15686 64103663
Complication of device insertion 11.05 10.01 8 379375 5004 64114345
Pancreatic duct stenosis 11.03 10.01 10 379373 229 64119120
Paranoia 11.01 10.01 54 379329 16298 64103051
Nephrotic syndrome 10.99 10.01 25 379358 9542 64109807
Skin infection 10.96 10.01 136 379247 14901 64104448
Benign ovarian tumour 10.96 10.01 11 379372 287 64119062
Musculoskeletal discomfort 10.93 10.01 145 379238 16132 64103217
Failed induction of labour 10.92 10.01 10 379373 232 64119117
Bundle branch block left 10.91 10.01 27 379356 10007 64109342
Device leakage 10.86 10.01 20 379363 8246 64111103
COVID-19 pneumonia 10.83 10.01 55 379328 16449 64102900
Vascular rupture 10.83 10.01 24 379359 1298 64118051
Prostatic specific antigen increased 10.80 10.01 22 379361 8738 64110611
Hypertriglyceridaemia 10.79 10.01 32 379351 11173 64108176
Hyperhomocysteinaemia 10.79 10.01 13 379370 418 64118931
Vascular insufficiency 10.79 10.01 14 379369 486 64118863
Photophobia 10.78 10.01 152 379231 17141 64102208
Generalised oedema 10.77 10.01 75 379308 20778 64098571
Uterine perforation 10.75 10.01 11 379372 5809 64113540
Inflammatory bowel disease 10.74 10.01 54 379329 4484 64114865
Hyperlipidaemia 10.73 10.01 85 379298 22891 64096458
Muscular weakness 10.72 10.01 626 378757 126712 63992637
Genital haemorrhage 10.70 10.01 10 379373 5512 64113837
Salivary hypersecretion 10.68 10.01 36 379347 12077 64107272
Oedema 10.68 10.01 437 378946 91498 64027851
Diaphragmatic disorder 10.67 10.01 25 379358 1403 64117946
Acute pulmonary oedema 10.66 10.01 39 379344 12770 64106579
Colitis microscopic 10.66 10.01 17 379366 7415 64111934
Tooth fracture 10.63 10.01 97 379286 9830 64109519
Cartilage injury 10.62 10.01 24 379359 1315 64118034
Hypoxic-ischaemic encephalopathy 10.60 10.01 16 379367 7136 64112213
Device related infection 10.60 10.01 122 379261 30504 64088845
Ventricular arrhythmia 10.60 10.01 17 379366 7398 64111951
Product administered to patient of inappropriate age 10.60 10.01 7 379376 4594 64114755
Gastroenteritis 10.58 10.01 239 379144 29472 64089877
Hernia pain 10.57 10.01 13 379370 427 64118922
Mental disorder 10.51 10.01 102 379281 26343 64093006
Lung neoplasm malignant 10.50 10.01 181 379202 21267 64098082
Decreased insulin requirement 10.47 10.01 8 379375 143 64119206
Brain natriuretic peptide increased 10.45 10.01 18 379365 7615 64111734
Intestinal stenosis 10.43 10.01 42 379341 3172 64116177
Impaired work ability 10.40 10.01 136 379247 15083 64104266
Diabetes mellitus inadequate control 10.37 10.01 78 379305 21243 64098106
Mycobacterium tuberculosis complex test positive 10.36 10.01 31 379352 2016 64117333
Hiatus hernia 10.35 10.01 170 379213 19787 64099562
Renal disorder 10.34 10.01 146 379237 35219 64084130
Complication of pregnancy 10.33 10.01 11 379372 308 64119041
Therapeutic product effect incomplete 10.31 10.01 724 378659 102758 64016591
Glomerular filtration rate decreased 10.30 10.01 70 379313 19502 64099847
Type 1 diabetes mellitus 10.29 10.01 11 379372 5694 64113655
Hepatic cytolysis 10.29 10.01 45 379338 14004 64105345
Troponin increased 10.29 10.01 51 379332 15348 64104001
Rash erythematous 10.25 10.01 213 379170 48420 64070929
Personality change 10.25 10.01 22 379361 8571 64110778
Thiopurine methyltransferase decreased 10.22 10.01 11 379372 312 64119037
Blood iron increased 10.17 10.01 24 379359 1353 64117996
Peripheral venous disease 10.15 10.01 68 379315 6270 64113079
Umbilical hernia 10.14 10.01 52 379331 4353 64114996
Aspiration 10.12 10.01 58 379325 16827 64102522
Twin pregnancy 10.10 10.01 18 379365 829 64118520
Respiratory tract infection viral 10.09 10.01 36 379347 2567 64116782
Dementia 10.09 10.01 76 379307 20690 64098659
Lymphadenectomy 10.08 10.01 20 379363 1000 64118349
Varicose ulceration 10.05 10.01 12 379371 382 64118967
Kidney transplant rejection 10.02 10.01 26 379357 9485 64109864
Crying 10.01 10.01 73 379310 20017 64099332

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D016588 Anticarcinogenic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D020011 Protective Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Amyloid beta A4 protein Unclassified IC50 6.75 CHEMBL
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

IDSource
4017713 VUID
N0000179229 NUI
D01621 KEGG_DRUG
4017637 VANDF
4017648 VANDF
4017713 VANDF
4021164 VANDF
C0073109 UMLSCUI
CHEBI:32095 CHEBI
CHEBI:50211 CHEBI
RTL PDB_CHEM_ID
CHEMBL986 ChEMBL_ID
CHEMBL486193 ChEMBL_ID
CHEMBL4297637 ChEMBL_ID
C009166 MESH_SUPPLEMENTAL_RECORD_UI
638034 PUBCHEM_CID
445354 PUBCHEM_CID
DB00162 DRUGBANK_ID
11246 RXNORM
232172 MMSL
5678 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
001001 NDDF
421621000 SNOMEDCT_US
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US
C0042839 UMLSCUI
2243 INN_ID
D014801 MESH_DESCRIPTOR_UI
3LE3D9D6OY UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 2000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 1000 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 1100 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 924 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 2500 [iU] ORAL unapproved drug other 10 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 42291-686 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
PNV Prenatal VitaminPlus Vitamin A HUMAN PRESCRIPTION DRUG LABEL 12 44946-1046 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 9 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 3080 [iU] ORAL Unapproved drug other 9 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 50268-677 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Escavite HUMAN PRESCRIPTION DRUG LABEL 17 58809-888 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 1500 ug ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 1500 ug ORAL unapproved drug other 13 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 1500 ug ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 1500 ug ORAL unapproved drug other 13 sections
Vitranol HUMAN PRESCRIPTION DRUG LABEL 17 59088-171 TABLET 1500 ug ORAL unapproved drug other 11 sections