quetiapine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3470.66 10.68 3471 237937 142202 63105412
Toxicity to various agents 3178.23 10.68 4285 237123 242965 63004649
Suicide attempt 2830.56 10.68 2128 239280 58790 63188824
Intentional overdose 2734.01 10.68 2260 239148 71892 63175722
Sopor 2698.34 10.68 1427 239981 20737 63226877
Drug abuse 2393.33 10.68 2074 239334 70444 63177170
Intentional self-injury 1486.42 10.68 1026 240382 24661 63222953
Overdose 1433.41 10.68 1968 239440 113110 63134504
Neuroleptic malignant syndrome 1423.89 10.68 761 240647 11295 63236319
Sedation 1122.46 10.68 1031 240377 37778 63209836
Drug interaction 1058.08 10.68 2543 238865 226588 63021026
Somnolence 1056.20 10.68 2189 239219 176496 63071118
Dystonia 993.17 10.68 632 240776 13187 63234427
Electrocardiogram QT prolonged 955.51 10.68 1155 240253 58375 63189239
Coma 911.78 10.68 1173 240235 63191 63184423
Tardive dyskinesia 810.13 10.68 466 240942 8036 63239578
Dyskinesia 762.12 10.68 764 240644 31238 63216376
Suicidal ideation 760.55 10.68 1057 240351 61364 63186250
Akathisia 671.43 10.68 424 240984 8722 63238892
Gestational diabetes 661.21 10.68 407 241001 7989 63239625
Depressed level of consciousness 657.98 10.68 984 240424 61094 63186520
Blood prolactin abnormal 643.05 10.68 287 241121 2792 63244822
Sexual dysfunction 635.24 10.68 317 241091 4042 63243572
Agitation 614.53 10.68 934 240474 58823 63188791
Extrapyramidal disorder 604.81 10.68 459 240949 12825 63234789
Mania 551.33 10.68 422 240986 11945 63235669
Liver injury 526.00 10.68 876 240532 59644 63187970
Serotonin syndrome 525.77 10.68 596 240812 28086 63219528
Anosognosia 524.31 10.68 252 241156 2944 63244670
Parkinsonism 482.53 10.68 364 241044 10075 63237539
Disturbance in social behaviour 471.23 10.68 252 241156 3741 63243873
Schizophrenia 466.63 10.68 350 241058 9602 63238012
Arthralgia 458.18 10.68 924 240484 568786 62678828
Muscle rigidity 440.76 10.68 359 241049 11141 63236473
Poisoning 419.50 10.68 376 241032 13324 63234290
Hallucination, auditory 418.70 10.68 365 241043 12459 63235155
Diabetes mellitus 410.95 10.68 751 240657 55059 63192555
Metabolic disorder 407.49 10.68 273 241135 6230 63241384
Tachycardia 403.08 10.68 1173 240235 116983 63130631
Diarrhoea 394.53 10.68 1399 240009 713967 62533647
Delusion 390.26 10.68 341 241067 11676 63235938
Bradyphrenia 385.32 10.68 271 241137 6709 63240905
Dyspnoea 383.73 10.68 1265 240143 660048 62587566
Personality change 362.50 10.68 261 241147 6712 63240902
Poisoning deliberate 361.64 10.68 317 241091 10901 63236713
Cardio-respiratory arrest 342.24 10.68 725 240683 59234 63188380
Restlessness 341.10 10.68 487 240921 28966 63218648
Altered state of consciousness 340.16 10.68 449 240959 24781 63222833
Delirium 328.60 10.68 645 240763 49896 63197718
Hypomania 324.65 10.68 235 241173 6095 63241519
Exposure during pregnancy 315.51 10.68 1299 240109 154248 63093366
Psychotic disorder 315.35 10.68 437 240971 25275 63222339
Aggression 313.44 10.68 416 240992 23082 63224532
Bradykinesia 311.22 10.68 212 241196 4976 63242638
Hallucination 301.54 10.68 653 240755 54164 63193450
Pain in extremity 284.74 10.68 516 240892 330970 62916644
Respiratory arrest 277.48 10.68 468 240940 32177 63215437
Pain 277.29 10.68 1668 239740 738960 62508654
Abnormal behaviour 273.07 10.68 371 241037 21055 63226559
Rash 270.08 10.68 1157 240251 559714 62687900
Cough 268.48 10.68 437 240971 292306 62955308
Tremor 267.04 10.68 1103 240305 131136 63116478
Febrile neutropenia 259.87 10.68 65 241343 118384 63129230
Intentional product misuse 256.83 10.68 654 240754 60263 63187351
Pruritus 256.46 10.68 627 240781 360826 62886788
Peripheral swelling 252.35 10.68 388 241020 265554 62982060
Sinus tachycardia 250.30 10.68 380 241028 23888 63223726
Confusional state 248.04 10.68 1643 239765 234737 63012877
Galactorrhoea 247.37 10.68 169 241239 3986 63243628
Joint swelling 247.18 10.68 550 240858 327116 62920498
Loss of consciousness 240.63 10.68 988 240420 117133 63130481
Stubbornness 240.43 10.68 79 241329 292 63247322
Bezoar 240.29 10.68 117 241291 1409 63246205
Metabolic syndrome 238.83 10.68 118 241290 1470 63246144
Sinusitis 230.40 10.68 315 241093 226338 63021276
Back pain 227.76 10.68 410 240998 263735 62983879
Psychomotor hyperactivity 227.40 10.68 240 241168 10423 63237191
Cardiac arrest 226.05 10.68 820 240588 91725 63155889
Malignant neoplasm progression 224.30 10.68 25 241383 82096 63165518
Mydriasis 223.41 10.68 251 241157 11705 63235909
Disease progression 219.23 10.68 96 241312 122662 63124952
Seizure 218.36 10.68 1041 240367 131593 63116021
Anticholinergic syndrome 214.81 10.68 126 241282 2256 63245358
Hyperprolactinaemia 214.29 10.68 151 241257 3749 63243865
Hallucinations, mixed 213.50 10.68 164 241244 4665 63242949
Suspected suicide 204.51 10.68 182 241226 6386 63241228
Fatigue 201.80 10.68 2285 239123 885743 62361871
Prescribed overdose 200.68 10.68 418 240990 33735 63213879
Nausea 198.72 10.68 2187 239221 852284 62395330
Nasopharyngitis 197.24 10.68 420 240988 253837 62993777
Headache 190.25 10.68 1520 239888 631721 62615893
Anaemia 185.27 10.68 539 240869 292891 62954723
Psoriatic arthropathy 185.15 10.68 764 240644 90756 63156858
Urinary retention 180.55 10.68 373 241035 29928 63217686
Catatonia 180.53 10.68 144 241264 4333 63243281
Paranoia 179.73 10.68 222 241186 11457 63236157
Obesity 177.64 10.68 368 241040 29584 63218030
Disorientation 175.11 10.68 432 240976 39020 63208594
Blood creatine phosphokinase increased 172.47 10.68 367 241041 30063 63217551
Bipolar disorder 171.24 10.68 180 241228 7780 63239834
Disturbance in attention 170.38 10.68 419 240989 37770 63209844
Respiratory depression 168.00 10.68 233 241175 13482 63234132
Herpes zoster 166.47 10.68 53 241355 82409 63165205
Orthostatic hypertension 164.25 10.68 65 241343 453 63247161
Pneumonia 163.96 10.68 1041 240367 455726 62791888
Substance abuse 163.34 10.68 140 241268 4667 63242947
Infection 159.63 10.68 401 241007 228772 63018842
Drug hypersensitivity 157.17 10.68 628 240780 310059 62937555
Diabetic coma 156.69 10.68 69 241339 648 63246966
Restless legs syndrome 156.58 10.68 265 241143 18266 63229348
Dysarthria 156.15 10.68 435 240973 42276 63205338
Urinary tract infection 155.78 10.68 502 240906 264182 62983432
Neuropathy peripheral 153.57 10.68 124 241284 113543 63134071
Thinking abnormal 152.15 10.68 195 241213 10448 63237166
Speech disorder 151.70 10.68 417 240991 40212 63207402
Anxiety 151.06 10.68 1374 240034 216167 63031447
Injection site erythema 148.55 10.68 65 241343 83109 63164505
Blood prolactin increased 144.09 10.68 114 241294 3389 63244225
Antipsychotic drug level increased 143.91 10.68 113 241295 3322 63244292
Withdrawal syndrome 141.97 10.68 265 241143 19732 63227882
Oculogyric crisis 139.51 10.68 85 241323 1636 63245978
Sepsis 137.94 10.68 231 241177 152892 63094722
Treatment noncompliance 136.30 10.68 380 241028 36945 63210669
Cogwheel rigidity 133.85 10.68 87 241321 1883 63245731
Labour complication 133.53 10.68 41 241367 114 63247500
Depersonalisation/derealisation disorder 132.82 10.68 76 241332 1296 63246318
Cardiac failure congestive 129.72 10.68 97 241311 92336 63155278
Injection site pain 129.19 10.68 183 241225 129617 63117997
Erythema 127.48 10.68 301 241107 175450 63072164
Type 2 diabetes mellitus 126.65 10.68 530 240878 63338 63184276
Miosis 126.63 10.68 148 241260 7205 63240409
Coma scale abnormal 126.26 10.68 125 241283 5028 63242586
COVID-19 125.42 10.68 147 241261 112956 63134658
Mucosal inflammation 123.91 10.68 16 241392 46912 63200702
Electrocardiogram QRS complex prolonged 123.69 10.68 132 241276 5806 63241808
Derealisation 122.56 10.68 69 241339 1139 63246475
Persecutory delusion 121.70 10.68 94 241314 2696 63244918
Hypotension 120.65 10.68 1574 239834 271030 62976584
Hypersensitivity 119.83 10.68 639 240769 292046 62955568
Arthritis 117.79 10.68 161 241247 115760 63131854
Influenza 117.69 10.68 144 241264 108578 63139036
Irritability 117.03 10.68 324 241084 31370 63216244
Drug ineffective 115.67 10.68 3060 238348 1041705 62205909
Torsade de pointes 115.55 10.68 193 241215 13158 63234456
Pleurothotonus 115.48 10.68 69 241339 1280 63246334
Drug withdrawal syndrome 114.61 10.68 292 241116 26902 63220712
Hyperreflexia 113.30 10.68 126 241282 5808 63241806
Hallucination, visual 113.13 10.68 236 241172 19062 63228552
Hyperammonaemic encephalopathy 112.75 10.68 85 241323 2349 63245265
Unresponsive to stimuli 111.60 10.68 332 241076 33484 63214130
Obsessive-compulsive disorder 109.84 10.68 104 241304 3956 63243658
Myoclonus 109.80 10.68 208 241200 15660 63231954
Platelet count decreased 109.43 10.68 170 241238 115952 63131662
Salivary hypersecretion 107.30 10.68 139 241269 7527 63240087
Pyrexia 106.52 10.68 1210 240198 469268 62778346
Myoglobin urine present 106.20 10.68 54 241354 718 63246896
Malaise 105.81 10.68 1041 240367 414913 62832701
Mood altered 105.44 10.68 196 241212 14547 63233067
Haemoglobin decreased 104.82 10.68 250 241158 145235 63102379
Drug withdrawal syndrome neonatal 103.85 10.68 76 241332 2005 63245609
Mood swings 103.30 10.68 220 241188 18028 63229586
Cellulitis 102.69 10.68 96 241312 81862 63165752
Impulse-control disorder 102.14 10.68 53 241355 737 63246877
Bipolar I disorder 100.81 10.68 72 241336 1827 63245787
Drug intolerance 100.80 10.68 723 240685 307938 62939676
Feeling of despair 100.27 10.68 78 241330 2261 63245353
Psychomotor retardation 98.77 10.68 96 241312 3774 63243840
Disorganised speech 98.77 10.68 61 241347 1204 63246410
Skin ulcer 97.56 10.68 22 241386 43023 63204591
Rhabdomyolysis 96.92 10.68 377 241031 43574 63204040
Atrial fibrillation 96.88 10.68 185 241223 116451 63131163
Infusion related reaction 96.63 10.68 543 240865 244978 63002636
Hypokinesia 94.36 10.68 181 241227 13755 63233859
Chest discomfort 93.48 10.68 172 241236 109797 63137817
Dissociation 93.10 10.68 82 241326 2837 63244777
Weight increased 91.88 10.68 1447 239961 259345 62988269
Bronchitis 91.34 10.68 213 241195 124722 63122892
Mental disorder 90.83 10.68 260 241148 25659 63221955
Sleep-related eating disorder 90.13 10.68 50 241358 801 63246813
Foetal exposure during pregnancy 89.98 10.68 297 241111 31665 63215949
Depression 89.15 10.68 1140 240268 195352 63052262
Somnambulism 87.93 10.68 107 241301 5436 63242178
Gastric pH decreased 86.17 10.68 47 241361 727 63246887
Nasal congestion 85.74 10.68 74 241334 65586 63182028
Nightmare 84.97 10.68 210 241198 18984 63228630
Circulatory collapse 84.71 10.68 228 241180 21710 63225904
Injection site pruritus 84.19 10.68 33 241375 45083 63202531
Bone pain 83.79 10.68 52 241356 54589 63193025
Injection site swelling 83.64 10.68 38 241370 47534 63200080
Pancytopenia 82.93 10.68 151 241257 96782 63150832
Psychomotor skills impaired 82.57 10.68 70 241338 2298 63245316
Hypotonia neonatal 82.15 10.68 54 241354 1192 63246422
Hypotonia 81.40 10.68 135 241273 9150 63238464
Medication error 81.37 10.68 404 241004 51880 63195734
Product dose omission issue 81.32 10.68 539 240869 233774 63013840
Gastrointestinal haemorrhage 81.19 10.68 114 241294 81062 63166552
Flushing 80.67 10.68 100 241308 74987 63172627
Infarction 79.88 10.68 72 241336 2569 63245045
Device expulsion 78.84 10.68 18 241390 34904 63212710
Gastrointestinal disorder 78.45 10.68 247 241161 130992 63116622
Breast cancer 77.07 10.68 44 241364 48339 63199275
Myelosuppression 76.94 10.68 3 241405 23700 63223914
Pneumonia aspiration 76.74 10.68 297 241111 34243 63213371
Dyspnoea exertional 76.29 10.68 70 241338 60232 63187382
Prescribed underdose 75.79 10.68 267 241141 29422 63218192
Synovitis 75.36 10.68 410 240998 186508 63061106
Anger 74.97 10.68 154 241254 12302 63235312
Apathy 74.61 10.68 126 241282 8668 63238946
Jaundice cholestatic 74.54 10.68 114 241294 7210 63240404
Drug screen positive 74.40 10.68 80 241328 3549 63244065
Plasma cell myeloma 74.39 10.68 22 241386 35883 63211731
Suicidal behaviour 74.08 10.68 69 241339 2570 63245044
Electrocardiogram QRS complex shortened 73.97 10.68 36 241372 433 63247181
Drooling 73.62 10.68 82 241326 3786 63243828
Rhinorrhoea 72.93 10.68 85 241323 65492 63182122
Myocardial infarction 72.45 10.68 171 241237 99722 63147892
Amenorrhoea 72.40 10.68 133 241275 9781 63237833
Coma blister 72.24 10.68 26 241382 134 63247480
Dry skin 72.01 10.68 66 241342 56821 63190793
Urticaria 71.15 10.68 356 241052 165446 63082168
Long QT syndrome 70.26 10.68 74 241334 3205 63244409
Interstitial lung disease 70.19 10.68 79 241329 61829 63185785
Osteonecrosis of jaw 70.12 10.68 23 241385 35100 63212514
Myalgia 69.73 10.68 303 241105 146226 63101388
Hyperthermia 69.62 10.68 125 241283 9031 63238583
Swelling 69.15 10.68 691 240717 274687 62972927
Stupor 68.59 10.68 83 241325 4192 63243422
Basal cell carcinoma 68.26 10.68 12 241396 27979 63219635
Injection site reaction 68.21 10.68 73 241335 58451 63189163
Productive cough 68.09 10.68 84 241324 63124 63184490
Posture abnormal 67.45 10.68 62 241346 2270 63245344
Epistaxis 67.05 10.68 108 241300 72617 63174997
Bone marrow failure 66.32 10.68 15 241393 29275 63218339
Therapeutic product effect decreased 65.70 10.68 447 240961 192740 63054874
Generalised tonic-clonic seizure 64.05 10.68 249 241159 28767 63218847
Logorrhoea 63.57 10.68 62 241346 2448 63245166
Lower respiratory tract infection 63.31 10.68 273 241135 132034 63115580
Chills 63.20 10.68 220 241188 113158 63134456
Euphoric mood 62.83 10.68 85 241323 4802 63242812
Stomatitis 62.33 10.68 293 241115 138432 63109182
Mental impairment 61.77 10.68 154 241254 13997 63233617
Thrombosis 61.75 10.68 94 241314 64661 63182953
Oromandibular dystonia 61.45 10.68 33 241375 494 63247120
Neoplasm progression 61.13 10.68 31 241377 36397 63211217
Anaphylactic reaction 61.09 10.68 98 241310 66002 63181612
Potentiating drug interaction 60.99 10.68 79 241329 4277 63243337
Bradypnoea 60.37 10.68 71 241337 3479 63244135
Myocarditis 60.20 10.68 126 241282 10199 63237415
Depressed mood 60.03 10.68 307 241101 39884 63207730
Thermal burn 59.97 10.68 93 241315 5953 63241661
Psychiatric symptom 59.92 10.68 86 241322 5137 63242477
Blood pressure increased 59.15 10.68 367 241041 161695 63085919
Weight decreased 58.98 10.68 721 240687 276077 62971537
Diverticulitis 58.79 10.68 39 241369 39518 63208096
Cytomegalovirus infection 58.16 10.68 6 241402 20946 63226668
Pleural effusion 58.13 10.68 172 241236 93038 63154576
Palmar-plantar erythrodysaesthesia syndrome 58.05 10.68 9 241399 23006 63224608
Behaviour disorder 57.79 10.68 66 241342 3133 63244481
Exposure via ingestion 57.67 10.68 63 241345 2846 63244768
Full blood count decreased 57.59 10.68 14 241394 26010 63221604
Accidental overdose 57.25 10.68 207 241201 23102 63224512
Panic attack 57.14 10.68 201 241207 22130 63225484
Tachyphrenia 57.13 10.68 45 241363 1329 63246285
Aspiration 57.06 10.68 127 241281 10724 63236890
Oropharyngeal pain 57.04 10.68 177 241231 94310 63153304
Red blood cell sedimentation rate increased 56.90 10.68 50 241358 43932 63203682
Abdominal pain 56.78 10.68 780 240628 292676 62954938
Drug level increased 56.77 10.68 203 241205 22533 63225081
Labelled drug-drug interaction issue 56.74 10.68 41 241367 1060 63246554
Mutism 56.46 10.68 48 241360 1582 63246032
Abnormal weight gain 55.57 10.68 50 241358 1780 63245834
Postural tremor 55.53 10.68 27 241381 324 63247290
Ascites 55.52 10.68 44 241364 40684 63206930
Rash pruritic 54.94 10.68 89 241319 59710 63187904
Psychiatric decompensation 54.23 10.68 44 241364 1357 63246257
Hypertonia 54.15 10.68 77 241331 4560 63243054
Dementia 54.12 10.68 176 241232 18618 63228996
Therapeutic product effect incomplete 53.93 10.68 268 241140 124788 63122826
H1N1 influenza 53.77 10.68 48 241360 1691 63245923
Hypersexuality 53.46 10.68 30 241378 492 63247122
Localised infection 53.31 10.68 24 241384 30186 63217428
Pain in jaw 53.25 10.68 52 241356 43444 63204170
Clonus 52.69 10.68 76 241332 4560 63243054
Drug dependence 52.34 10.68 208 241200 24275 63223339
Asthenia 52.25 10.68 1087 240321 382517 62865097
Respiratory disorder neonatal 52.25 10.68 41 241367 1204 63246410
Pneumocystis jirovecii pneumonia 52.13 10.68 3 241405 16911 63230703
Polydipsia 52.05 10.68 66 241342 3498 63244116
Embolism venous 51.85 10.68 62 241346 3092 63244522
Surgery 51.26 10.68 37 241371 35875 63211739
Urinary hesitation 51.24 10.68 53 241355 2247 63245367
Throat irritation 50.91 10.68 41 241367 37606 63210008
Osteonecrosis 50.87 10.68 15 241393 24515 63223099
Full blood count abnormal 50.29 10.68 29 241379 31688 63215926
Injection site bruising 50.28 10.68 51 241357 41859 63205755
Impulsive behaviour 49.55 10.68 44 241364 1539 63246075
Nephrolithiasis 49.34 10.68 52 241356 41932 63205682
Conversion disorder 49.28 10.68 46 241362 1718 63245896
Refusal of examination 49.15 10.68 21 241387 182 63247432
Memory impairment 48.98 10.68 609 240799 103649 63143965
Schizoaffective disorder 48.94 10.68 64 241344 3498 63244116
Hypothermia 48.32 10.68 137 241271 13444 63234170
Viral infection 48.02 10.68 39 241369 35624 63211990
Hypervolaemia 47.95 10.68 24 241384 28389 63219225
Menstrual disorder 47.58 10.68 78 241330 5235 63242379
Acute kidney injury 47.47 10.68 710 240698 262705 62984909
Alcohol interaction 47.46 10.68 52 241356 2357 63245257
Foetal death 47.41 10.68 119 241289 10861 63236753
Metastases to bone 47.12 10.68 11 241397 21008 63226606
Osteomyelitis 46.98 10.68 20 241388 26000 63221614
Bundle branch block right 46.97 10.68 75 241333 4923 63242691
Respiratory tract infection 46.95 10.68 53 241355 41430 63206184
Cognitive disorder 46.83 10.68 368 241040 55447 63192167
Rectal haemorrhage 45.96 10.68 72 241336 48958 63198656
Colitis 45.74 10.68 71 241337 48457 63199157
Tic 45.11 10.68 41 241367 1479 63246135
Tension 45.11 10.68 58 241350 3117 63244497
Rabbit syndrome 45.02 10.68 23 241385 309 63247305
Hyperkinesia 44.86 10.68 43 241365 1661 63245953
Personality change due to a general medical condition 44.85 10.68 20 241388 194 63247420
Sympathomimetic effect 44.85 10.68 16 241392 80 63247534
Deep vein thrombosis postoperative 44.74 10.68 119 241289 11250 63236364
Chest pain 44.67 10.68 566 240842 215393 63032221
Enuresis 44.66 10.68 52 241356 2521 63245093
Treatment failure 44.47 10.68 513 240895 198530 63049084
Eosinophil count decreased 44.41 10.68 48 241360 2142 63245472
Toxic encephalopathy 43.99 10.68 85 241323 6494 63241120
Acute psychosis 43.77 10.68 51 241357 2474 63245140
Burning mouth syndrome 43.39 10.68 26 241382 485 63247129
Nephrogenic diabetes insipidus 43.34 10.68 33 241375 926 63246688
Procedural pain 43.27 10.68 14 241394 21555 63226059
Schizophreniform disorder 43.24 10.68 15 241393 68 63247546
Thrombocytopenia 43.21 10.68 367 241041 150790 63096824
Adrenal insufficiency 42.99 10.68 8 241400 17907 63229707
Septic shock 42.97 10.68 121 241287 66508 63181106
Urine osmolarity increased 42.89 10.68 17 241391 119 63247495
Food interaction 42.72 10.68 31 241377 807 63246807
Renal failure 42.62 10.68 267 241141 117385 63130229
Sinus disorder 42.56 10.68 20 241388 24533 63223081
Neck pain 42.44 10.68 129 241279 69189 63178425
Femur fracture 42.39 10.68 58 241350 41698 63205916
Psychotic behaviour 42.00 10.68 27 241381 573 63247041
Facet joint syndrome 41.79 10.68 121 241287 12017 63235597
Alcohol abuse 41.72 10.68 46 241362 2100 63245514
Nodule 41.57 10.68 14 241394 21012 63226602
Hypersomnia 41.54 10.68 157 241251 17898 63229716
Anaemia of pregnancy 41.26 10.68 15 241393 80 63247534
Psoriasis 41.24 10.68 180 241228 86777 63160837
Neoplasm malignant 41.03 10.68 32 241376 29829 63217785
Gastric disorder 40.94 10.68 49 241359 37320 63210294
Accidental poisoning 40.88 10.68 27 241381 601 63247013
Faecaloma 40.70 10.68 92 241316 7849 63239765
Upper respiratory tract infection 40.65 10.68 167 241241 81880 63165734
Alopecia 40.65 10.68 975 240433 336561 62911053
Blood triglycerides increased 40.62 10.68 122 241286 12366 63235248
Dehydration 40.61 10.68 442 240966 172912 63074702
Meconium aspiration syndrome 40.52 10.68 11 241397 16 63247598
Parkinsonian gait 40.45 10.68 25 241383 494 63247120
Acute myeloid leukaemia 40.42 10.68 8 241400 17139 63230475
Intestinal pseudo-obstruction 40.37 10.68 31 241377 881 63246733
Pancreatitis 40.37 10.68 322 241086 48733 63198881
Affect lability 40.18 10.68 113 241295 11038 63236576
Blood cholesterol increased 39.85 10.68 539 240869 93493 63154121
Metastases to liver 39.84 10.68 20 241388 23619 63223995
Fungal infection 39.71 10.68 49 241359 36825 63210789
Musculoskeletal pain 39.63 10.68 198 241210 92079 63155535
Ventricular fibrillation 39.61 10.68 117 241291 11750 63235864
Accidental death 39.53 10.68 43 241365 1933 63245681
Amnesia 39.46 10.68 353 241055 55232 63192382
Hypercalcaemia 39.36 10.68 30 241378 28292 63219322
Homicide 39.08 10.68 22 241386 363 63247251
Action tremor 39.01 10.68 21 241387 316 63247298
Tooth infection 38.96 10.68 10 241398 17910 63229704
Gastrooesophageal reflux disease 38.95 10.68 209 241199 95430 63152184
Right ventricular false tendon 38.87 10.68 10 241398 10 63247604
Joint stiffness 38.75 10.68 62 241346 41807 63205807
Leukopenia 38.70 10.68 457 240951 76833 63170781
Feeling of body temperature change 38.70 10.68 68 241340 4829 63242785
Bone density decreased 38.53 10.68 5 241403 14607 63233007
Clostridium difficile colitis 38.45 10.68 15 241393 20554 63227060
Anaphylactic shock 38.34 10.68 21 241387 23612 63224002
Conjunctival abrasion 38.33 10.68 11 241397 22 63247592
Pulmonary arterial hypertension 38.20 10.68 19 241389 22558 63225056
Coronary artery disease 38.16 10.68 40 241368 32337 63215277
Blood calcium decreased 38.08 10.68 27 241381 26424 63221190
Neutropenic sepsis 38.06 10.68 8 241400 16430 63231184
Laboratory test abnormal 38.05 10.68 28 241380 26884 63220730
Major depression 37.92 10.68 90 241318 7928 63239686
Troponin increased 37.89 10.68 104 241304 10017 63237597
Cerebrovascular accident 37.67 10.68 248 241160 107776 63139838
Lip dry 37.66 10.68 137 241271 15333 63232281
Bone disorder 37.54 10.68 17 241391 21309 63226305
Dyspepsia 37.50 10.68 231 241177 101965 63145649
Cytokine release syndrome 37.50 10.68 5 241403 14309 63233305
Chronic sinusitis 37.47 10.68 3 241405 12840 63234774
Negativism 37.45 10.68 22 241386 395 63247219
Gastroenteritis viral 37.10 10.68 22 241386 23678 63223936
Oral pain 37.06 10.68 32 241376 28362 63219252
Self-injurious ideation 36.88 10.68 48 241360 2611 63245003
Eczema 36.83 10.68 41 241367 32250 63215364
Tenderness 36.72 10.68 20 241388 22558 63225056
Loss of personal independence in daily activities 36.70 10.68 218 241190 97072 63150542
Pneumonitis 36.69 10.68 48 241360 35174 63212440
Amniotic fluid volume increased 36.64 10.68 16 241392 147 63247467
White blood cell count decreased 36.58 10.68 345 241063 138759 63108855
Antidepressant drug level above therapeutic 36.49 10.68 22 241386 415 63247199
Injection site rash 36.36 10.68 13 241395 18796 63228818
Blood glucose increased 35.86 10.68 481 240927 83275 63164339
Limb discomfort 35.83 10.68 36 241372 29680 63217934
Emotional disorder 35.60 10.68 122 241286 13257 63234357
Apraxia 35.34 10.68 39 241369 1782 63245832
Osmolar gap increased 35.20 10.68 14 241394 99 63247515
Impaired healing 34.96 10.68 237 241171 102305 63145309
Swollen joint count increased 34.95 10.68 246 241162 35808 63211806
Insurance issue 34.88 10.68 74 241334 6047 63241567
Congenital vesicoureteric reflux 34.85 10.68 10 241398 20 63247594
Fluid retention 34.48 10.68 114 241294 59572 63188042
Adjustment disorder with mixed anxiety and depressed mood 34.39 10.68 14 241394 106 63247508
Injection site urticaria 34.39 10.68 6 241402 14067 63233547
Skin exfoliation 34.36 10.68 70 241338 43032 63204582
Mouth ulceration 34.31 10.68 45 241363 32939 63214675
Social anxiety disorder 34.20 10.68 21 241387 410 63247204
Amylase increased 34.20 10.68 75 241333 6270 63241344
Gynaecomastia 34.04 10.68 17 241391 217 63247397
Cystitis 33.90 10.68 102 241306 54889 63192725
Bacteraemia 33.52 10.68 12 241396 17336 63230278
Cardiac failure 33.48 10.68 200 241208 88942 63158672
Pulmonary hypertension 33.40 10.68 56 241352 37067 63210547
Myelodysplastic syndrome 33.39 10.68 11 241397 16743 63230871
Dysphonia 33.33 10.68 83 241325 47531 63200083
Abdominal discomfort 33.30 10.68 947 240461 319938 62927676
Homicidal ideation 33.10 10.68 37 241371 1715 63245899
Therapy interrupted 33.02 10.68 45 241363 32410 63215204
Slow response to stimuli 32.93 10.68 29 241379 1003 63246611
Peripheral venous disease 32.69 10.68 131 241277 15346 63232268
Breast cancer female 32.66 10.68 6 241402 13553 63234061
Disinhibition 32.64 10.68 27 241381 856 63246758
Congenital hand malformation 32.63 10.68 18 241390 285 63247329
Contusion 32.61 10.68 389 241019 149655 63097959
Sinus congestion 32.60 10.68 14 241394 18109 63229505
Borderline personality disorder 32.52 10.68 26 241382 785 63246829
Depressive symptom 32.47 10.68 57 241351 4045 63243569
Stoma site discharge 32.36 10.68 35 241373 1563 63246051
Somatic symptom disorder 32.29 10.68 45 241363 2615 63244999
Device difficult to use 32.28 10.68 5 241403 12791 63234823
Renal impairment 32.26 10.68 200 241208 88155 63159459
Dysgeusia 32.25 10.68 82 241326 46628 63200986
Ulcer 32.20 10.68 31 241377 26076 63221538
Alcohol poisoning 32.01 10.68 38 241370 1881 63245733
Bradycardia 31.95 10.68 422 240986 72805 63174809
Hyperthermia malignant 31.88 10.68 26 241382 808 63246806
Hyperammonaemia 31.86 10.68 65 241343 5167 63242447
Tubulointerstitial nephritis 31.84 10.68 18 241390 19885 63227729
Inappropriate affect 31.83 10.68 27 241381 887 63246727
Gastrointestinal sounds abnormal 31.69 10.68 56 241352 3995 63243619
Granulocytopenia 31.66 10.68 68 241340 5604 63242010
Atrioventricular block first degree 31.58 10.68 79 241329 7194 63240420
Attention deficit hyperactivity disorder 31.47 10.68 48 241360 3028 63244586
Renal papillary necrosis 31.39 10.68 17 241391 259 63247355
Ear infection 31.37 10.68 61 241347 38152 63209462
Affective disorder 31.27 10.68 71 241337 6075 63241539
Stereotypy 31.21 10.68 20 241388 422 63247192
Hyperphagia 30.95 10.68 36 241372 1743 63245871
Congenital thrombocytopenia 30.84 10.68 11 241397 55 63247559
Ataxia 30.81 10.68 127 241281 15068 63232546
Disseminated intravascular coagulation 30.80 10.68 17 241391 19034 63228580
Arrhythmia 30.65 10.68 249 241159 37891 63209723
Apnoea 30.59 10.68 83 241325 7939 63239675
Electrocardiogram repolarisation abnormality 30.52 10.68 31 241377 1286 63246328
Tongue biting 30.27 10.68 33 241375 1487 63246127
Nuchal rigidity 30.19 10.68 23 241385 646 63246968
Self esteem decreased 30.07 10.68 23 241385 650 63246964
Tonic clonic movements 30.06 10.68 32 241376 1403 63246211
Hot flush 30.05 10.68 97 241311 51062 63196552
Clostridium difficile infection 29.93 10.68 42 241366 29880 63217734
Skin necrosis 29.91 10.68 8 241400 13942 63233672
Upper-airway cough syndrome 29.88 10.68 4 241404 11414 63236200
Asthma-chronic obstructive pulmonary disease overlap syndrome 29.83 10.68 38 241370 2023 63245591
Emotional poverty 29.79 10.68 18 241390 341 63247273
Right ventricular failure 29.79 10.68 14 241394 17174 63230440
Adjustment disorder with depressed mood 29.78 10.68 96 241312 10108 63237506
Haemophagocytic lymphohistiocytosis 29.61 10.68 3 241405 10624 63236990
Product substitution issue 29.58 10.68 130 241278 15866 63231748
Psychotic symptom 29.55 10.68 33 241375 1528 63246086
Hyporesponsive to stimuli 29.33 10.68 28 241380 1076 63246538
Antidepressant drug level increased 29.25 10.68 17 241391 299 63247315
Neonatal hypoxia 29.03 10.68 22 241386 613 63247001
Schizoaffective disorder bipolar type 28.90 10.68 13 241395 129 63247485
Haemorrhoids 28.87 10.68 25 241383 22125 63225489
Flatulence 28.83 10.68 55 241353 34647 63212967
Job dissatisfaction 28.71 10.68 10 241398 46 63247568
Alcoholism 28.68 10.68 35 241373 1783 63245831
Transfusion 28.60 10.68 11 241397 15206 63232408
Pressure of speech 28.52 10.68 23 241385 703 63246911
Musculoskeletal disorder 28.52 10.68 22 241386 20622 63226992
Feeling guilty 28.47 10.68 21 241387 561 63247053
Hospitalisation 28.33 10.68 198 241210 84883 63162731
Tendonitis 28.27 10.68 20 241388 19595 63228019
Candida infection 28.15 10.68 40 241368 28311 63219303
Sleep disorder due to a general medical condition 28.08 10.68 6 241402 12182 63235432
Peripartum cardiomyopathy 27.81 10.68 13 241395 142 63247472
Colitis ulcerative 27.75 10.68 35 241373 26056 63221558
Vomiting 27.74 10.68 1795 239613 557822 62689792
Cataract 27.72 10.68 117 241291 56936 63190678
Hypertonia neonatal 27.67 10.68 15 241393 229 63247385
Hyperhidrosis 27.52 10.68 569 240839 107267 63140347
Ventricular arrhythmia 27.51 10.68 51 241357 3777 63243837
Floppy iris syndrome 27.50 10.68 12 241396 110 63247504
Incontinence 27.47 10.68 102 241306 11530 63236084
Angioedema 27.44 10.68 92 241316 47873 63199741
Osteopenia 27.44 10.68 21 241387 19764 63227850
Diverticulum 27.43 10.68 6 241402 11985 63235629
Burning sensation 27.42 10.68 110 241298 54297 63193317
Malignant melanoma 27.40 10.68 5 241403 11351 63236263
Akinesia 27.32 10.68 32 241376 1561 63246053
Uveitis 27.30 10.68 7 241401 12546 63235068
Inflammation 27.13 10.68 192 241216 82081 63165533
Post-traumatic stress disorder 27.10 10.68 61 241347 5190 63242424
Injury 27.09 10.68 410 240998 72837 63174777
Maternal exposure during pregnancy 27.07 10.68 1058 240350 219004 63028610
Rheumatic fever 26.72 10.68 266 241142 42845 63204769
Self-medication 26.71 10.68 42 241366 2721 63244893
Single umbilical artery 26.67 10.68 15 241393 247 63247367
Angina pectoris 26.48 10.68 46 241362 30032 63217582
Electrocardiogram abnormal 26.46 10.68 86 241322 9093 63238521
Total lung capacity increased 26.44 10.68 38 241370 2272 63245342
Blood pressure systolic increased 26.38 10.68 92 241316 47305 63200309
Colitis ischaemic 26.21 10.68 95 241313 10613 63237001
Hypoacusis 26.10 10.68 32 241376 24119 63223495
Red blood cell count decreased 26.06 10.68 74 241334 40571 63207043
Muscle disorder 25.95 10.68 58 241350 4911 63242703
Aplastic anaemia 25.90 10.68 3 241405 9566 63238048
Skin reaction 25.88 10.68 12 241396 14837 63232777
Urine sodium increased 25.88 10.68 11 241397 94 63247520
Dry mouth 25.84 10.68 428 240980 77435 63170179
Seasonal allergy 25.69 10.68 25 241383 20925 63226689
Persistent genital arousal disorder 25.45 10.68 15 241393 271 63247343
Injection site warmth 25.39 10.68 13 241395 15182 63232432
Gastritis 25.36 10.68 66 241342 37237 63210377
Constipation 25.36 10.68 656 240752 224287 63023327
Tremor neonatal 25.28 10.68 12 241396 136 63247478
Haematotoxicity 25.23 10.68 3 241405 9373 63238241
Torticollis 25.21 10.68 34 241374 1915 63245699
Chorea 25.19 10.68 31 241377 1593 63246021
Morbid thoughts 25.04 10.68 20 241388 603 63247011
Binge eating 24.96 10.68 18 241390 464 63247150
Hypocalcaemia 24.86 10.68 52 241356 31661 63215953
Dermatitis 24.82 10.68 17 241391 16941 63230673
Haematochezia 24.68 10.68 112 241296 53432 63194182
Chronic kidney disease 24.68 10.68 89 241319 45309 63202305
Colon cancer 24.60 10.68 4 241404 9874 63237740
Therapeutic product ineffective 24.60 10.68 32 241376 1740 63245874
Abulia 24.59 10.68 18 241390 475 63247139
Pyramidal tract syndrome 24.59 10.68 16 241392 347 63247267
Unevaluable event 24.58 10.68 106 241302 51280 63196334
Protein C increased 24.55 10.68 11 241397 108 63247506
Muscle twitching 24.49 10.68 143 241265 19525 63228089
Joint injury 24.45 10.68 47 241361 29525 63218089
Eye pruritus 24.42 10.68 21 241387 18650 63228964
Congenital hearing disorder 24.40 10.68 7 241401 14 63247600
Cyanosis 24.34 10.68 128 241280 16807 63230807
Herbal interaction 24.29 10.68 11 241397 111 63247503
Cytopenia 24.23 10.68 7 241401 11594 63236020
Carpal tunnel syndrome 24.21 10.68 26 241382 20791 63226823
Adulterated product 24.20 10.68 14 241394 244 63247370
Diabetes insipidus 24.13 10.68 39 241369 2586 63245028
Autoimmune disorder 24.12 10.68 129 241279 17048 63230566
Withdrawal catatonia 24.09 10.68 10 241398 80 63247534
Distributive shock 24.09 10.68 28 241380 1355 63246259
Neonatal disorder 24.04 10.68 19 241389 564 63247050
Inappropriate schedule of product administration 23.96 10.68 266 241142 103699 63143915
Blunted affect 23.95 10.68 14 241394 249 63247365
Eye irritation 23.86 10.68 29 241379 21942 63225672
Food craving 23.86 10.68 30 241378 1576 63246038
Metastases to central nervous system 23.77 10.68 10 241398 13095 63234519
Physical assault 23.75 10.68 23 241385 900 63246714
Lacrimation increased 23.74 10.68 26 241382 20605 63227009
On and off phenomenon 23.72 10.68 32 241376 1803 63245811
Cervix neoplasm 23.67 10.68 13 241395 204 63247410
Formication 23.44 10.68 51 241357 4240 63243374
Slow speech 23.42 10.68 29 241379 1500 63246114
Lymphocyte count decreased 23.39 10.68 50 241358 30207 63217407
Wrong patient received product 23.38 10.68 35 241373 2172 63245442
Infantile apnoea 23.37 10.68 24 241384 1009 63246605
Proteinuria 23.30 10.68 23 241385 19122 63228492
Lymphadenopathy 23.23 10.68 72 241336 38386 63209228
Device stimulation issue 23.21 10.68 9 241399 59 63247555
Status epilepticus 23.19 10.68 117 241291 15116 63232498
Live birth 23.18 10.68 172 241236 25458 63222156
Bronchospasm 23.14 10.68 19 241389 17261 63230353
Eosinopenia 23.11 10.68 8 241400 36 63247578
Tuberculosis 22.99 10.68 7 241401 11204 63236410
Social avoidant behaviour 22.98 10.68 41 241367 2947 63244667
Decreased interest 22.94 10.68 43 241365 3211 63244403
Bruxism 22.91 10.68 45 241363 3480 63244134
Staphylococcal parotitis 22.88 10.68 5 241403 0 63247614
Hyperkalaemia 22.87 10.68 117 241291 54086 63193528
Pulmonary oedema 22.84 10.68 119 241289 54754 63192860
Decreased bronchial secretion 22.83 10.68 9 241399 62 63247552
Ammonia increased 22.82 10.68 53 241355 4603 63243011
Labelled drug-food interaction medication error 22.81 10.68 12 241396 172 63247442
Drug level above therapeutic 22.79 10.68 54 241354 4751 63242863
Gout 22.71 10.68 11 241397 13260 63234354
Hypoglycaemia neonatal 22.69 10.68 23 241385 952 63246662
Incoherent 22.68 10.68 52 241356 4478 63243136
Atelectasis 22.66 10.68 29 241379 21454 63226160
Bronchopulmonary aspergillosis 22.66 10.68 3 241405 8632 63238982
Ageusia 22.56 10.68 12 241396 13716 63233898
Drug reaction with eosinophilia and systemic symptoms 22.55 10.68 212 241196 33624 63213990
Product tampering 22.54 10.68 16 241392 402 63247212
Language disorder 22.52 10.68 34 241374 2126 63245488
Pulmonary mass 22.32 10.68 32 241376 22564 63225050
Meconium in amniotic fluid 22.29 10.68 14 241394 285 63247329
Respiratory tract congestion 22.19 10.68 21 241387 17811 63229803
Trismus 22.17 10.68 47 241361 3838 63243776
Infusion site pain 22.03 10.68 19 241389 16850 63230764
No adverse event 21.96 10.68 82 241326 41323 63206291
Epilepsy 21.91 10.68 177 241231 26888 63220726
Product storage error 21.88 10.68 15 241393 14941 63232673
Haemorrhage 21.82 10.68 139 241269 60883 63186731
Progressive multifocal leukoencephalopathy 21.82 10.68 11 241397 12960 63234654
Creatinine renal clearance decreased 21.75 10.68 18 241390 16290 63231324
Faeces discoloured 21.66 10.68 23 241385 18486 63229128
Depressive delusion 21.61 10.68 6 241402 10 63247604
Mental status changes 21.55 10.68 238 241170 39361 63208253
Musculoskeletal discomfort 21.39 10.68 22 241386 17945 63229669
Fibromyalgia 21.39 10.68 427 240981 79993 63167621
Post procedural complication 21.38 10.68 20 241388 17054 63230560
Spasmodic dysphonia 21.37 10.68 9 241399 75 63247539
Gastroenteritis 21.35 10.68 43 241365 26547 63221067
Device related infection 21.31 10.68 35 241373 23357 63224257
Vitamin K decreased 21.25 10.68 6 241402 11 63247603
Patient uncooperative 21.21 10.68 12 241396 200 63247414
Starvation ketoacidosis 21.16 10.68 9 241399 77 63247537
Haematuria 21.06 10.68 50 241358 29107 63218507
Metastases to lymph nodes 21.01 10.68 3 241405 8155 63239459
Lymphoma 21.01 10.68 10 241398 12177 63235437
Small for dates baby 20.97 10.68 45 241363 3706 63243908
Decreased appetite 20.96 10.68 762 240646 250290 62997324
Parasomnia 20.88 10.68 17 241391 527 63247087
Drug screen false positive 20.84 10.68 21 241387 863 63246751
Neonatal respiratory distress syndrome 20.82 10.68 38 241370 2780 63244834
Multiple sclerosis relapse 20.82 10.68 104 241304 48374 63199240
Osteoporosis 20.82 10.68 130 241278 57208 63190406
Psychotic disorder due to a general medical condition 20.77 10.68 13 241395 263 63247351
Generalised anxiety disorder 20.71 10.68 32 241376 2042 63245572
Electrocardiogram ST segment elevation 20.69 10.68 46 241362 3881 63243733
Suppressed lactation 20.68 10.68 16 241392 460 63247154
Dependence 20.67 10.68 32 241376 2045 63245569
Upper limb fracture 20.64 10.68 25 241383 18943 63228671
Discoloured vomit 20.64 10.68 21 241387 873 63246741
Merycism 20.55 10.68 13 241395 268 63247346
Breast cancer metastatic 20.51 10.68 10 241398 12008 63235606
Spinal stenosis 20.50 10.68 16 241392 14909 63232705
Feelings of worthlessness 20.50 10.68 14 241394 330 63247284
Pupillary light reflex tests abnormal 20.46 10.68 11 241397 165 63247449
Neurodegenerative disorder 20.46 10.68 14 241394 331 63247283
Pneumothorax 20.42 10.68 19 241389 16242 63231372
C-reactive protein increased 20.39 10.68 246 241162 94461 63153153
Post procedural haemorrhage 20.35 10.68 3 241405 7961 63239653
Paralysis 20.27 10.68 83 241325 9817 63237797
Oropharyngeal spasm 20.26 10.68 13 241395 275 63247339
Deafness 20.26 10.68 23 241385 17934 63229680
Intervertebral disc protrusion 20.21 10.68 37 241371 23672 63223942
Dyslipidaemia 20.18 10.68 68 241340 7325 63240289
Electrocardiogram QT interval abnormal 20.12 10.68 11 241397 171 63247443
Claustrophobia 20.10 10.68 22 241386 996 63246618
Spinal compression fracture 20.01 10.68 15 241393 14268 63233346
Negative thoughts 20.00 10.68 21 241387 906 63246708
Multiple allergies 19.98 10.68 14 241394 13788 63233826
Spinal fracture 19.97 10.68 24 241384 18247 63229367
Blood iron decreased 19.94 10.68 16 241392 14705 63232909
Neonatal hypotension 19.93 10.68 10 241398 129 63247485
Foot deformity 19.93 10.68 48 241360 27805 63219809
Lupus vulgaris 19.91 10.68 59 241349 5935 63241679
Cortisol increased 19.91 10.68 15 241393 414 63247200
Abnormal dreams 19.85 10.68 86 241322 10430 63237184
Anterior displaced anus 19.72 10.68 6 241402 16 63247598
Aphasia 19.67 10.68 202 241206 32798 63214816
Bladder dilatation 19.55 10.68 20 241388 837 63246777
Dry eye 19.55 10.68 84 241324 40677 63206937
Tongue spasm 19.49 10.68 8 241400 62 63247552
Muscle spasticity 19.49 10.68 33 241375 21761 63225853
Drug use disorder 19.44 10.68 52 241356 4932 63242682
Somatic symptom disorder of pregnancy 19.44 10.68 9 241399 96 63247518
Sense of a foreshortened future 19.43 10.68 5 241403 5 63247609
Oral herpes 19.41 10.68 44 241364 26030 63221584
Breast engorgement 19.36 10.68 9 241399 97 63247517
Selective eating disorder 19.35 10.68 31 241377 2041 63245573
Acute generalised exanthematous pustulosis 19.30 10.68 9 241399 11090 63236524
Pulmonary artery stenosis congenital 19.25 10.68 12 241396 241 63247373
Pancreatic carcinoma 19.20 10.68 3 241405 7625 63239989
Oedema peripheral 19.20 10.68 561 240847 188950 63058664
Gastric ulcer 19.19 10.68 39 241369 23998 63223616
Teratoma benign 19.17 10.68 8 241400 65 63247549
Nail disorder 19.11 10.68 13 241395 13002 63234612
Defect conduction intraventricular 19.09 10.68 10 241398 142 63247472
Agranulocytosis 19.07 10.68 162 241246 24972 63222642
Asterixis 19.01 10.68 25 241383 1374 63246240
Dislocation of vertebra 18.97 10.68 74 241334 8561 63239053
Fear of weight gain 18.97 10.68 6 241402 19 63247595
Stoma site hypergranulation 18.94 10.68 13 241395 309 63247305
Osteoarthritis 18.91 10.68 252 241156 95091 63152523
Ill-defined disorder 18.91 10.68 209 241199 81546 63166068
Vasculitis 18.78 10.68 25 241383 18184 63229430
Influenza like illness 18.75 10.68 163 241245 66661 63180953
Anion gap increased 18.74 10.68 29 241379 1853 63245761
Hallucination, olfactory 18.74 10.68 12 241396 253 63247361
Skin disorder 18.72 10.68 54 241354 29453 63218161
Delusional disorder, unspecified type 18.69 10.68 14 241394 383 63247231
Parosmia 18.67 10.68 59 241349 6147 63241467
Sleep disorder due to general medical condition, insomnia type 18.64 10.68 119 241289 52098 63195516
Swelling face 18.63 10.68 153 241255 63322 63184292
Orthostatic hypotension 18.62 10.68 215 241193 35945 63211669
Sluggishness 18.60 10.68 53 241355 5216 63242398
Electrocardiogram T wave inversion 18.59 10.68 41 241367 3440 63244174
Cardiac disorder 18.56 10.68 115 241293 50701 63196913
Idiopathic intracranial hypertension 18.54 10.68 37 241371 2894 63244720
Brain injury 18.54 10.68 64 241344 6979 63240635
Therapy cessation 18.41 10.68 57 241351 30400 63217214
Psychogenic tremor 18.30 10.68 6 241402 22 63247592
Tooth disorder 18.25 10.68 51 241357 28106 63219508
Skin lesion 18.21 10.68 58 241350 30663 63216951
Hypertension 18.19 10.68 872 240536 278431 62969183
Total lung capacity decreased 18.15 10.68 31 241377 2152 63245462
Pseudomonas infection 18.14 10.68 10 241398 11203 63236411
Metabolic acidosis 18.13 10.68 256 241152 44813 63202801
Lymphoedema 18.10 10.68 11 241397 11681 63235933
Infusion site erythema 18.06 10.68 11 241397 11668 63235946
Cerebellar atrophy 18.06 10.68 18 241390 730 63246884
Abdominal pain upper 18.05 10.68 623 240785 205821 63041793
Distal intestinal obstruction syndrome 18.05 10.68 14 241394 404 63247210
Pneumonia viral 18.05 10.68 4 241404 7918 63239696
Ejection fraction decreased 18.03 10.68 36 241372 22296 63225318
Eye haemorrhage 17.98 10.68 5 241403 8491 63239123
Convulsive threshold lowered 17.89 10.68 13 241395 339 63247275
Aortic bruit 17.89 10.68 6 241402 24 63247590
Rotator cuff syndrome 17.89 10.68 15 241393 13487 63234127
Complication associated with device 17.82 10.68 23 241385 16955 63230659
Radial nerve palsy 17.78 10.68 15 241393 489 63247125
Fear of injection 17.62 10.68 3 241405 7161 63240453
Vestibular migraine 17.51 10.68 11 241397 224 63247390
Ankylosing spondylitis 17.44 10.68 9 241399 10465 63237149
Bronchopulmonary aspergillosis allergic 17.39 10.68 31 241377 2227 63245387
Grandiosity 17.38 10.68 12 241396 288 63247326
Disturbance in sexual arousal 17.35 10.68 9 241399 125 63247489
Oral candidiasis 17.35 10.68 38 241370 22760 63224854
Pathological fracture 17.26 10.68 6 241402 8828 63238786
Urinary incontinence 17.23 10.68 192 241216 31822 63215792
Immunosuppression 17.19 10.68 6 241402 8808 63238806
Haematoma 17.16 10.68 71 241337 34749 63212865
Post procedural infection 17.15 10.68 7 241401 9335 63238279
Bipolar II disorder 17.10 10.68 13 241395 364 63247250
Antipsychotic drug level below therapeutic 17.10 10.68 12 241396 296 63247318
Cyst 17.09 10.68 17 241391 14082 63233532
Tooth abscess 17.07 10.68 19 241389 14950 63232664
Rash maculo-papular 17.02 10.68 63 241345 31833 63215781
Encephalopathy 17.02 10.68 223 241185 38397 63209217
Female genital tract fistula 16.86 10.68 4 241404 7555 63240059
Delusional perception 16.85 10.68 11 241397 240 63247374
Compulsive sexual behaviour 16.76 10.68 7 241401 57 63247557
Indifference 16.74 10.68 9 241399 135 63247479
Confabulation 16.68 10.68 12 241396 308 63247306
Movement disorder 16.64 10.68 140 241268 21521 63226093
Resting tremor 16.62 10.68 18 241390 805 63246809
Rebound psychosis 16.62 10.68 10 241398 188 63247426
Enthesopathy 16.57 10.68 6 241402 8608 63239006
Wrong dose 16.56 10.68 22 241386 1221 63246393
Injection site haemorrhage 16.54 10.68 43 241365 24271 63223343
Flight of ideas 16.50 10.68 14 241394 460 63247154
Cardiopulmonary failure 16.50 10.68 40 241368 3572 63244042
Rapid eye movement sleep behaviour disorder 16.48 10.68 12 241396 314 63247300
Polyarthritis 16.48 10.68 9 241399 10137 63237477
Sudden death 16.43 10.68 81 241327 10368 63237246
Poverty of speech 16.42 10.68 12 241396 316 63247298
Resuscitation 16.41 10.68 21 241387 1123 63246491
Agitated depression 16.34 10.68 11 241397 253 63247361
Toxic epidermal necrolysis 16.33 10.68 46 241362 25288 63222326
Device dislocation 16.33 10.68 47 241361 25658 63221956
Tongue movement disturbance 16.32 10.68 12 241396 319 63247295
False positive investigation result 16.29 10.68 16 241392 637 63246977
Maternal exposure during breast feeding 16.29 10.68 44 241364 4197 63243417
Type 1 diabetes mellitus 16.28 10.68 41 241367 3749 63243865
Gait deviation 16.25 10.68 7 241401 62 63247552
Bradycardia neonatal 16.12 10.68 19 241389 933 63246681
Diffuse large B-cell lymphoma 16.10 10.68 3 241405 6709 63240905
Dementia with Lewy bodies 16.09 10.68 12 241396 326 63247288
Skin infection 16.08 10.68 20 241388 14982 63232632
Somatic hallucination 16.08 10.68 4 241404 3 63247611
Child abuse 16.08 10.68 4 241404 3 63247611
Sleep disorder 16.03 10.68 415 240993 81151 63166463
Eye movement disorder 16.00 10.68 50 241358 5178 63242436
Pneumonia bacterial 15.96 10.68 8 241400 9457 63238157
Product use issue 15.96 10.68 1007 240401 219513 63028101
Illusion 15.92 10.68 20 241388 1050 63246564
Nerve injury 15.90 10.68 9 241399 9937 63237677
Escherichia infection 15.90 10.68 15 241393 12739 63234875
Synovial cyst 15.89 10.68 10 241398 10423 63237191
Compartment syndrome 15.88 10.68 30 241378 2254 63245360
Rhinitis 15.84 10.68 12 241396 11354 63236260
Head titubation 15.84 10.68 18 241390 850 63246764
Neuropsychiatric symptoms 15.78 10.68 17 241391 756 63246858
Obsessive-compulsive symptom 15.69 10.68 7 241401 68 63247546
Atrial septal defect 15.69 10.68 60 241348 6878 63240736
Megacolon 15.67 10.68 27 241381 1888 63245726
Neutrophil count decreased 15.64 10.68 138 241270 56268 63191346
Enteritis 15.56 10.68 6 241402 8280 63239334
Conjunctivitis 15.55 10.68 35 241373 20761 63226853
Hypogammaglobulinaemia 15.54 10.68 4 241404 7151 63240463
Postmortem blood drug level abnormal 15.48 10.68 12 241396 346 63247268
Device issue 15.47 10.68 43 241365 23738 63223876
Blood potassium decreased 15.40 10.68 95 241313 41931 63205683
Oedema 15.39 10.68 483 240925 97139 63150475
Central obesity 15.34 10.68 21 241387 1200 63246414
Labelled drug-food interaction issue 15.32 10.68 5 241403 18 63247596
Arthritis infective 15.32 10.68 3 241405 6475 63241139
Diastolic dysfunction 15.29 10.68 3 241405 6468 63241146
Asphyxia 15.27 10.68 55 241353 6126 63241488
Breast discharge 15.20 10.68 19 241389 992 63246622
Hypomagnesaemia 15.18 10.68 57 241351 28680 63218934
Migraine 15.18 10.68 289 241119 103057 63144557
Haemoptysis 15.16 10.68 57 241351 28669 63218945
Reduced facial expression 15.15 10.68 27 241381 1939 63245675
Tricuspid valve incompetence 15.15 10.68 20 241388 14601 63233013
Respiratory syncytial virus infection 15.10 10.68 4 241404 7014 63240600
Pathogen resistance 15.05 10.68 3 241405 6395 63241219
Frontotemporal dementia 15.04 10.68 12 241396 361 63247253
Eosinophilic cellulitis 15.02 10.68 6 241402 43 63247571
Hypoglycaemia 15.01 10.68 316 241092 59749 63187865
Food refusal 14.99 10.68 12 241396 363 63247251
Total cholesterol/HDL ratio abnormal 14.93 10.68 7 241401 77 63247537
Thrombotic microangiopathy 14.92 10.68 11 241397 10550 63237064
Myoclonic epilepsy 14.90 10.68 21 241387 1233 63246381
Lip swelling 14.90 10.68 64 241344 30999 63216615
Suspiciousness 14.88 10.68 12 241396 367 63247247
Intervertebral disc degeneration 14.84 10.68 23 241385 15709 63231905
Product quality issue 14.80 10.68 78 241330 35787 63211827
Crepitations 14.80 10.68 6 241402 8034 63239580
Hostility 14.80 10.68 26 241382 1846 63245768
Sudden cardiac death 14.74 10.68 28 241380 2112 63245502
Antipsychotic drug level above therapeutic 14.73 10.68 19 241389 1024 63246590
Gestational hypertension 14.68 10.68 30 241378 2387 63245227
Increased appetite 14.68 10.68 74 241334 9556 63238058
Freezing phenomenon 14.67 10.68 21 241387 1251 63246363
Pseudobulbar palsy 14.66 10.68 4 241404 6 63247608
Peripheral sensory neuropathy 14.66 10.68 5 241403 7446 63240168
Adverse drug reaction 14.64 10.68 402 241006 79312 63168302
Soliloquy 14.59 10.68 10 241398 237 63247377
Drug diversion 14.55 10.68 18 241390 930 63246684
Blepharospasm 14.51 10.68 53 241355 5943 63241671
Induced abortion failed 14.41 10.68 10 241398 242 63247372
Malignant polyp 14.38 10.68 9 241399 182 63247432
Compulsive shopping 14.29 10.68 16 241392 743 63246871
Large for dates baby 14.28 10.68 13 241395 470 63247144
Nystagmus 14.24 10.68 54 241354 6166 63241448
Device malfunction 14.23 10.68 29 241379 17828 63229786
Abscess 14.21 10.68 26 241382 16642 63230972
Product dispensing error 14.20 10.68 77 241331 10228 63237386
Acidosis 14.20 10.68 82 241326 11151 63236463
Irregular sleep phase 14.18 10.68 5 241403 24 63247590
Squamous cell carcinoma of skin 14.17 10.68 3 241405 6129 63241485
Dysphagia 14.15 10.68 439 240969 88146 63159468
Pupil fixed 14.14 10.68 25 241383 1784 63245830
Intellectual disability 14.13 10.68 19 241389 1067 63246547
Dysuria 14.12 10.68 193 241215 33545 63214069
Generalised oedema 14.10 10.68 24 241384 15794 63231820
Antisocial behaviour 14.08 10.68 12 241396 397 63247217
Infective pulmonary exacerbation of cystic fibrosis 14.06 10.68 8 241400 8809 63238805
Postmortem blood drug level 14.05 10.68 8 241400 135 63247479
Drowning 14.05 10.68 13 241395 480 63247134
CSWS syndrome 14.02 10.68 5 241403 25 63247589
Transient ischaemic attack 14.02 10.68 85 241323 37668 63209946
Immune reconstitution inflammatory syndrome 14.01 10.68 3 241405 6081 63241533
Neuralgia 13.97 10.68 51 241357 25875 63221739
Ballismus 13.95 10.68 8 241400 137 63247477
Amimia 13.94 10.68 6 241402 53 63247561
Reflexes abnormal 13.94 10.68 15 241393 666 63246948
Lung perforation 13.90 10.68 7 241401 91 63247523
Retrograde amnesia 13.89 10.68 13 241395 487 63247127
Rib fracture 13.86 10.68 42 241366 22555 63225059
Neonatal behavioural syndrome 13.85 10.68 6 241402 54 63247560
Visceral congestion 13.85 10.68 11 241397 329 63247285
Mitral valve incompetence 13.83 10.68 34 241374 19560 63228054
Choking 13.74 10.68 74 241334 9805 63237809
Blood magnesium decreased 13.73 10.68 18 241390 13180 63234434
Cerebral haemorrhage 13.73 10.68 65 241343 30664 63216950
Micrographia 13.73 10.68 3 241405 0 63247614
Buccoglossal syndrome 13.73 10.68 3 241405 0 63247614
Erotomanic delusion 13.73 10.68 3 241405 0 63247614
Hypothermia neonatal 13.73 10.68 3 241405 0 63247614
Diabetic cardiomyopathy 13.73 10.68 3 241405 0 63247614
Autonomic nervous system imbalance 13.73 10.68 32 241376 2786 63244828
Muscular weakness 13.72 10.68 357 241051 121996 63125618
Screaming 13.71 10.68 35 241373 3227 63244387
Facial pain 13.66 10.68 12 241396 10549 63237065
Central nervous system injury 13.65 10.68 8 241400 143 63247471
Facial spasm 13.62 10.68 15 241393 684 63246930
Eye swelling 13.60 10.68 46 241362 23872 63223742
Ear pain 13.58 10.68 81 241327 36037 63211577
Genital labial adhesions 13.55 10.68 5 241403 28 63247586
Inappropriate antidiuretic hormone secretion 13.55 10.68 103 241305 15359 63232255
Irritable bowel syndrome 13.52 10.68 226 241182 82186 63165428
Aphthous ulcer 13.51 10.68 20 241388 13918 63233696
Diabetic complication 13.48 10.68 17 241391 896 63246718
Postoperative wound infection 13.44 10.68 13 241395 10912 63236702
Ileus 13.42 10.68 99 241309 14626 63232988
Neonatal seizure 13.42 10.68 13 241395 509 63247105
Bradycardia foetal 13.41 10.68 12 241396 424 63247190
Delusional disorder, erotomanic type 13.41 10.68 5 241403 29 63247585
Dissociative amnesia 13.41 10.68 5 241403 29 63247585
Joint effusion 13.35 10.68 28 241380 17032 63230582
Hiatus hernia 13.35 10.68 40 241368 21554 63226060
Cardiac failure acute 13.34 10.68 10 241398 9513 63238101
Oesophageal food impaction 13.33 10.68 9 241399 208 63247406
Arthritis bacterial 13.31 10.68 4 241404 6459 63241155
Blood urine present 13.31 10.68 23 241385 15046 63232568
Leukopenia neonatal 13.26 10.68 5 241403 30 63247584
Eye infection 13.22 10.68 16 241392 12129 63235485
Electroconvulsive therapy 13.21 10.68 6 241402 61 63247553
Spinal disorder 13.12 10.68 11 241397 9891 63237723
Insomnia 13.11 10.68 969 240439 214283 63033331
Agitation neonatal 13.11 10.68 13 241395 524 63247090
Floppy infant 13.08 10.68 7 241401 104 63247510
Immobilisation prolonged 13.08 10.68 7 241401 104 63247510
Perinatal depression 13.07 10.68 15 241393 716 63246898
Pulseless electrical activity 13.06 10.68 60 241348 7461 63240153
Diabetic hyperosmolar coma 13.03 10.68 11 241397 359 63247255
Temperature regulation disorder 13.03 10.68 52 241356 6080 63241534
Hyperinsulinaemia 13.02 10.68 7 241401 105 63247509
Bone marrow eosinophilic leukocyte count increased 12.99 10.68 5 241403 32 63247582
Pulmonary embolism 12.95 10.68 555 240853 116129 63131485
Brain hypoxia 12.92 10.68 13 241395 533 63247081
Neurological decompensation 12.90 10.68 30 241378 2608 63245006
Kidney infection 12.88 10.68 45 241363 23131 63224483
Bacterial infection 12.87 10.68 35 241373 19464 63228150
Echolalia 12.86 10.68 9 241399 221 63247393
Eye injury 12.84 10.68 32 241376 2907 63244707
Hyponatraemia 12.82 10.68 534 240874 111366 63136248
Lack of spontaneous speech 12.82 10.68 8 241400 161 63247453
Infusion site swelling 12.76 10.68 11 241397 9759 63237855
Depression suicidal 12.74 10.68 24 241384 1799 63245815
Ventricular tachycardia 12.73 10.68 124 241284 19855 63227759
Groin pain 12.72 10.68 12 241396 10191 63237423
Peripheral circulatory failure 12.69 10.68 17 241391 951 63246663
Injection site discolouration 12.69 10.68 7 241401 7841 63239773
Encopresis 12.68 10.68 7 241401 111 63247503
Ventricular extrasystoles 12.68 10.68 82 241326 11605 63236009
Poor venous access 12.66 10.68 23 241385 14762 63232852
Jealous delusion 12.62 10.68 5 241403 35 63247579
Dissociative disorder 12.60 10.68 11 241397 376 63247238
Hygroma colli 12.57 10.68 4 241404 13 63247601
Crying 12.57 10.68 140 241268 23203 63224411
Sneezing 12.56 10.68 32 241376 18186 63229428
Ileus paralytic 12.55 10.68 42 241366 4509 63243105
C-reactive protein 12.54 10.68 44 241364 4838 63242776
Lactation disorder 12.53 10.68 11 241397 379 63247235
Immune thrombocytopenia 12.48 10.68 13 241395 10543 63237071
Gastrointestinal inflammation 12.45 10.68 3 241405 5609 63242005
Thyroid cancer 12.45 10.68 3 241405 5608 63242006
Breath sounds abnormal 12.44 10.68 14 241394 10959 63236655
Skin haemorrhage 12.43 10.68 12 241396 10082 63237532
Duodenal ulcer 12.43 10.68 7 241401 7749 63239865
Neonatal respiratory distress 12.41 10.68 11 241397 384 63247230
Dopamine dysregulation syndrome 12.35 10.68 8 241400 172 63247442
Gallbladder disorder 12.31 10.68 34 241374 18808 63228806
Bladder cancer 12.30 10.68 3 241405 5563 63242051
Bronchial aspiration procedure 12.27 10.68 8 241400 174 63247440
Ovarian germ cell cancer stage II 12.27 10.68 6 241402 73 63247541
Gangrene 12.24 10.68 4 241404 6119 63241495
Pulmonary haemorrhage 12.21 10.68 6 241402 7175 63240439
Unintentional medical device removal 12.21 10.68 4 241404 6111 63241503
Bladder prolapse 12.21 10.68 26 241382 2130 63245484
Anal sphincter atony 12.18 10.68 9 241399 241 63247373
Allergic hepatitis 12.15 10.68 5 241403 39 63247575
Blindness 12.15 10.68 42 241366 21657 63225957
Blood osmolarity increased 12.15 10.68 9 241399 242 63247372
Personality disorder 12.12 10.68 49 241359 5762 63241852
Initial insomnia 12.12 10.68 51 241357 6106 63241508
Stoma site erythema 12.12 10.68 19 241389 1228 63246386
Dysphoria 12.11 10.68 44 241364 4922 63242692
Energy increased 12.10 10.68 30 241378 2717 63244897
Regressive behaviour 12.08 10.68 8 241400 179 63247435
Thrombotic thrombocytopenic purpura 12.03 10.68 37 241371 3799 63243815
Breast enlargement 12.01 10.68 22 241386 1614 63246000
Metabolic alkalosis 12.00 10.68 32 241376 3029 63244585
Bundle branch block 12.00 10.68 16 241392 891 63246723
Dropped head syndrome 12.00 10.68 8 241400 181 63247433
General physical health deterioration 11.99 10.68 905 240503 200497 63047117
Heart rate decreased 11.96 10.68 113 241295 45447 63202167
Ocular hyperaemia 11.94 10.68 52 241356 25092 63222522
Tongue paralysis 11.93 10.68 9 241399 249 63247365
Dysmetropsia 11.92 10.68 6 241402 78 63247536
SARS-CoV-2 test positive 11.89 10.68 8 241400 8048 63239566
Splenomegaly 11.83 10.68 15 241393 11142 63236472
Ligament sprain 11.80 10.68 19 241389 12781 63234833
Snoring 11.78 10.68 39 241369 4163 63243451
Pulse absent 11.76 10.68 46 241362 5328 63242286
Breast swelling 11.73 10.68 20 241388 1386 63246228
Therapeutic response changed 11.69 10.68 17 241391 1028 63246586
Hypovolaemia 11.68 10.68 14 241394 10659 63236955
Water intoxication 11.67 10.68 11 241397 416 63247198
Congenital emphysema 11.66 10.68 3 241405 3 63247611
Electrolyte substitution therapy 11.66 10.68 3 241405 3 63247611
Abdominal pain lower 11.66 10.68 54 241354 25624 63221990
Female sexual dysfunction 11.64 10.68 5 241403 44 63247570
Malignant catatonia 11.59 10.68 8 241400 192 63247422
Libido decreased 11.58 10.68 29 241379 2643 63244971
Product use in unapproved indication 11.56 10.68 810 240598 178270 63069344
Flail chest 11.53 10.68 6 241402 84 63247530
Judgement impaired 11.51 10.68 15 241393 817 63246797
Hypophosphataemia 11.47 10.68 16 241392 11410 63236204
Melaena 11.46 10.68 68 241340 30297 63217317
X-ray abnormal 11.45 10.68 61 241347 8049 63239565
Oxygen saturation decreased 11.44 10.68 253 241155 88332 63159282
Oscillopsia 11.43 10.68 7 241401 136 63247478
Poriomania 11.40 10.68 6 241402 86 63247528
Acute coronary syndrome 11.39 10.68 13 241395 10113 63237501
Enterocolitis 11.34 10.68 8 241400 7850 63239764
Rectal prolapse 11.33 10.68 24 241384 1959 63245655
Tachypnoea 11.33 10.68 108 241300 17194 63230420
Frequent bowel movements 11.31 10.68 47 241361 22975 63224639
Polyhydramnios 11.29 10.68 26 241382 2245 63245369
Road traffic accident 11.29 10.68 199 241209 36433 63211181
Acinetobacter bacteraemia 11.28 10.68 6 241402 88 63247526
Hernia 11.28 10.68 19 241389 12555 63235059
Congestive cardiomyopathy 11.25 10.68 50 241358 6132 63241482
Tearfulness 11.24 10.68 38 241370 4101 63243513
Skin discolouration 11.18 10.68 91 241317 37737 63209877
Abnormal loss of weight 11.17 10.68 4 241404 5778 63241836
Kidney duplex 11.17 10.68 5 241403 49 63247565
Lactate pyruvate ratio increased 11.16 10.68 6 241402 90 63247524
Cholecystitis acute 11.16 10.68 9 241399 8251 63239363
Electroencephalogram abnormal 11.13 10.68 35 241373 3637 63243977
Impaired self-care 11.11 10.68 23 241385 1847 63245767
Metastasis 11.11 10.68 3 241405 5194 63242420
Tendon rupture 11.10 10.68 9 241399 8230 63239384
Burnout syndrome 11.10 10.68 8 241400 206 63247408
Skull fracture 11.08 10.68 17 241391 1078 63246536
Impaired work ability 11.07 10.68 32 241376 17443 63230171
Compulsions 11.07 10.68 8 241400 207 63247407
Duplicate therapy error 11.05 10.68 6 241402 92 63247522
Blood creatinine increased 11.03 10.68 252 241156 87592 63160022
Musculoskeletal chest pain 11.02 10.68 42 241366 21041 63226573
Neurological examination abnormal 11.00 10.68 9 241399 281 63247333
White blood cell count abnormal 10.95 10.68 5 241403 6237 63241377
Mass 10.93 10.68 23 241385 13977 63233637
Splenic injury 10.90 10.68 8 241400 212 63247402
Hysterectomy 10.90 10.68 12 241396 9487 63238127
Gingival pain 10.90 10.68 9 241399 8153 63239461
Diarrhoea haemorrhagic 10.85 10.68 11 241397 9031 63238583
Sleep talking 10.84 10.68 16 241392 980 63246634
Premature delivery 10.81 10.68 69 241339 30212 63217402
Posterior reversible encephalopathy syndrome 10.81 10.68 32 241376 17313 63230301
Liver function test abnormal 10.81 10.68 124 241284 48057 63199557
Panic disorder 10.81 10.68 28 241380 2605 63245009
Subdural haematoma 10.81 10.68 24 241384 14304 63233310
Oesophageal candidiasis 10.80 10.68 4 241404 5659 63241955
Accommodation disorder 10.77 10.68 10 241398 371 63247243
Device breakage 10.77 10.68 17 241391 11525 63236089
Spinal pain 10.76 10.68 21 241387 13118 63234496
Foetal chromosome abnormality 10.75 10.68 4 241404 23 63247591
Eye disorder 10.72 10.68 47 241361 22638 63224976
Neurological symptom 10.69 10.68 47 241361 5736 63241878

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1805.55 11.62 2091 138026 96077 34720737
Neuroleptic malignant syndrome 1728.81 11.62 1008 139109 16926 34799888
Toxicity to various agents 1566.47 11.62 2841 137276 197521 34619293
Suicide attempt 1423.38 11.62 1210 138907 37906 34778908
Sopor 1243.53 11.62 710 139407 11426 34805388
Drug interaction 1210.01 11.62 2739 137378 223207 34593607
Intentional overdose 913.15 11.62 996 139121 42678 34774136
Drug abuse 833.96 11.62 1454 138663 97642 34719172
Overdose 805.39 11.62 1366 138751 89693 34727121
Psychotic disorder 803.24 11.62 714 139403 23738 34793076
Depression 777.35 11.62 1394 138723 95704 34721110
Sedation 759.72 11.62 648 139469 20358 34796456
Agitation 689.79 11.62 992 139125 56407 34760407
Aggression 641.74 11.62 786 139331 38178 34778636
Somnolence 626.89 11.62 1378 138739 109738 34707076
Extrapyramidal disorder 589.59 11.62 456 139661 12424 34804390
Coma 587.98 11.62 816 139301 44862 34771952
Dyskinesia 560.90 11.62 563 139554 21850 34794964
Tardive dyskinesia 545.78 11.62 321 139796 5469 34811345
Dystonia 538.36 11.62 403 139714 10442 34806372
Depressed level of consciousness 513.86 11.62 740 139377 42101 34774713
Akathisia 498.09 11.62 343 139774 7766 34809048
Diarrhoea 483.48 11.62 512 139605 389400 34427414
Priapism 476.31 11.62 279 139838 4715 34812099
Intentional self-injury 469.80 11.62 411 139706 13360 34803454
Hallucination 452.57 11.62 771 139346 50727 34766087
Paranoia 452.04 11.62 380 139737 11688 34805126
Suicidal ideation 420.48 11.62 653 139464 39735 34777079
Delusion 418.81 11.62 371 139746 12264 34804550
Catatonia 375.00 11.62 240 139877 4785 34812029
Electrocardiogram QT prolonged 362.20 11.62 615 139502 40337 34776477
Dyspnoea 346.52 11.62 614 139503 376168 34440646
Muscle rigidity 338.98 11.62 304 139813 10214 34806600
Restlessness 319.88 11.62 450 139667 25032 34791782
Mania 314.65 11.62 279 139838 9232 34807582
Febrile neutropenia 302.10 11.62 87 140030 136762 34680052
Hallucination, auditory 290.08 11.62 295 139822 11622 34805192
Parkinsonism 283.81 11.62 246 139871 7892 34808922
Diabetes mellitus 278.21 11.62 594 139523 46279 34770535
Poisoning deliberate 261.27 11.62 231 139886 7613 34809201
Serotonin syndrome 260.60 11.62 359 139758 19574 34797240
Psychiatric decompensation 253.81 11.62 154 139963 2783 34814031
Arthralgia 253.60 11.62 187 139930 169854 34646960
Abnormal behaviour 250.44 11.62 397 139720 24572 34792242
Obsessive-compulsive disorder 245.90 11.62 193 139924 5371 34811443
Delirium 245.68 11.62 544 139573 43447 34773367
Pneumonia 245.57 11.62 698 139419 361929 34454885
Bradyphrenia 241.88 11.62 180 139937 4618 34812196
Fatigue 240.44 11.62 728 139389 369925 34446889
Blood creatine phosphokinase increased 238.54 11.62 544 139573 44313 34772501
Nausea 236.22 11.62 646 139471 339262 34477552
Confusional state 234.50 11.62 1170 138947 142990 34673824
Oculogyric crisis 230.18 11.62 117 140000 1469 34815345
Anaemia 228.94 11.62 364 139753 232971 34583843
Rash 228.61 11.62 337 139780 222415 34594399
Psychomotor hyperactivity 224.78 11.62 233 139884 9389 34807425
Disease progression 220.21 11.62 79 140038 107998 34708816
Malignant neoplasm progression 215.57 11.62 45 140072 88001 34728813
Schizophrenia 206.32 11.62 212 139905 8454 34808360
Euphoric mood 201.72 11.62 173 139944 5468 34811346
Foetal exposure during pregnancy 201.37 11.62 461 139656 37640 34779174
Rhabdomyolysis 194.09 11.62 658 139459 67505 34749309
Blood prolactin abnormal 193.64 11.62 89 140028 880 34815934
Poisoning 192.02 11.62 241 139876 11985 34804829
Drug withdrawal syndrome neonatal 191.95 11.62 140 139977 3479 34813335
Hallucination, visual 189.71 11.62 291 139826 17500 34799314
Altered state of consciousness 189.48 11.62 334 139783 22559 34794255
Emotional poverty 185.66 11.62 75 140042 523 34816291
Anxiety 184.05 11.62 838 139279 98590 34718224
Antipsychotic drug level below therapeutic 183.50 11.62 119 139998 2428 34814386
Intentional product misuse 183.21 11.62 497 139620 45114 34771700
Weight increased 181.90 11.62 797 139320 92236 34724578
Atrial fibrillation 181.84 11.62 135 139982 122258 34694556
Cough 179.86 11.62 202 139915 149938 34666876
Disinhibition 178.41 11.62 128 139989 3098 34813716
Tremor 164.85 11.62 712 139405 81875 34734939
Tachycardia 164.76 11.62 725 139392 84047 34732767
Tearfulness 159.49 11.62 111 140006 2556 34814258
Bradykinesia 159.13 11.62 129 139988 3764 34813050
Neuropathy peripheral 157.82 11.62 68 140049 83195 34733619
Depression suicidal 156.26 11.62 107 140010 2398 34814416
Cardiac failure congestive 156.25 11.62 69 140048 83201 34733613
Sepsis 155.58 11.62 268 139849 166293 34650521
Pruritus 155.26 11.62 205 139912 141776 34675038
Sexual dysfunction 155.14 11.62 157 139960 6146 34810668
Depressive symptom 154.82 11.62 112 140005 2747 34814067
Psychomotor skills impaired 154.55 11.62 127 139990 3779 34813035
Pyrexia 153.11 11.62 751 139366 332262 34484552
Hyperprolactinaemia 151.74 11.62 89 140028 1507 34815307
Prescribed overdose 151.70 11.62 200 139917 10447 34806367
Anosognosia 150.66 11.62 75 140042 898 34815916
Apathy 146.21 11.62 159 139958 6773 34810041
Hyperreflexia 143.38 11.62 112 140005 3094 34813720
Speech disorder 141.49 11.62 316 139801 25370 34791444
Irritability 140.81 11.62 308 139809 24382 34792432
Pain 139.55 11.62 392 139725 204283 34612531
Joint swelling 137.81 11.62 35 140082 59855 34756959
Bezoar 135.63 11.62 74 140043 1083 34815731
Therapeutic product effect variable 134.79 11.62 97 140020 2359 34814455
Hypomania 133.67 11.62 95 140022 2264 34814550
Acute kidney injury 129.28 11.62 707 139410 304281 34512533
Asthenia 128.23 11.62 527 139590 244724 34572090
Disturbance in social behaviour 127.29 11.62 84 140033 1767 34815047
Social avoidant behaviour 124.78 11.62 102 140015 3012 34813802
Interstitial lung disease 122.61 11.62 54 140063 65228 34751586
Platelet count decreased 121.73 11.62 182 139935 119535 34697279
Type 2 diabetes mellitus 121.31 11.62 225 139892 15807 34801007
Thrombocytopenia 121.31 11.62 280 139837 155967 34660847
Loss of personal independence in daily activities 119.91 11.62 348 139769 32831 34783983
Decreased appetite 119.90 11.62 310 139807 166082 34650732
Pain in extremity 119.50 11.62 202 139915 126311 34690503
Restless legs syndrome 119.13 11.62 157 139960 8197 34808617
Back pain 118.25 11.62 191 139926 121598 34695216
Miosis 116.07 11.62 166 139951 9369 34807445
Pleural effusion 115.91 11.62 94 140023 81452 34735362
Haemoglobin decreased 115.77 11.62 191 139926 120581 34696233
Psychotic symptom 114.79 11.62 77 140040 1666 34815148
Psychomotor retardation 114.63 11.62 104 140013 3546 34813268
Increased appetite 114.36 11.62 145 139972 7284 34809530
Cognitive disorder 113.52 11.62 311 139806 28382 34788432
Obesity 111.90 11.62 192 139925 12686 34804128
Salivary hypersecretion 110.42 11.62 154 139963 8490 34808324
Insomnia 109.83 11.62 753 139364 103154 34713660
Infection 109.12 11.62 122 139995 90793 34726021
Diabetic coma 108.46 11.62 59 140058 858 34815956
Bipolar disorder 108.34 11.62 101 140016 3568 34813246
Headache 106.76 11.62 428 139689 200207 34616607
Infusion related reaction 105.94 11.62 40 140077 53017 34763797
Dysarthria 105.36 11.62 343 139774 34439 34782375
Metabolic syndrome 104.62 11.62 72 140045 1627 34815187
Disorientation 103.90 11.62 331 139786 32857 34783957
Blood prolactin increased 102.33 11.62 72 140045 1688 34815126
Urticaria 100.31 11.62 63 140054 62314 34754500
Persecutory delusion 100.22 11.62 83 140034 2497 34814317
Mydriasis 100.10 11.62 134 139983 7103 34809711
Stomatitis 99.44 11.62 24 140093 42490 34774324
Respiratory arrest 99.28 11.62 292 139825 27751 34789063
Drug hypersensitivity 98.92 11.62 106 140011 80423 34736391
Hyperkalaemia 98.59 11.62 80 140037 69309 34747505
Suspected suicide 98.55 11.62 108 140009 4640 34812174
COVID-19 97.59 11.62 100 140017 77450 34739364
Rheumatoid arthritis 96.78 11.62 18 140099 38220 34778594
Pancytopenia 96.38 11.62 145 139972 95012 34721802
Respiratory disorder neonatal 95.51 11.62 67 140050 1563 34815251
Gastrointestinal haemorrhage 93.36 11.62 131 139986 88346 34728468
Oedema peripheral 92.71 11.62 215 139902 119597 34697217
Nasopharyngitis 91.75 11.62 87 140030 69881 34746933
Mental disorder 91.60 11.62 194 139923 15015 34801799
Drug withdrawal syndrome 90.74 11.62 227 139890 19607 34797207
Sedation complication 90.31 11.62 67 140050 1710 34815104
Mental impairment 89.82 11.62 154 139963 10168 34806646
Withdrawal syndrome 89.51 11.62 171 139946 12284 34804530
Plasma cell myeloma 88.54 11.62 29 140088 42008 34774806
Schizoaffective disorder 88.30 11.62 59 140058 1268 34815546
Hypertonia neonatal 87.43 11.62 41 140076 426 34816388
Metabolic disorder 84.72 11.62 95 140022 4188 34812626
Sinus tachycardia 84.00 11.62 203 139914 17157 34799657
Anger 83.98 11.62 162 139955 11722 34805092
Selective eating disorder 83.62 11.62 64 140053 1714 34815100
Dementia 83.53 11.62 176 139941 13572 34803242
Sleep disorder 82.40 11.62 297 139820 31391 34785423
Seizure 82.33 11.62 709 139408 104148 34712666
Suicidal behaviour 81.87 11.62 59 140058 1438 34815376
Myocardial infarction 81.59 11.62 233 139884 120852 34695962
Posture abnormal 80.73 11.62 69 140048 2170 34814644
Treatment noncompliance 80.54 11.62 272 139845 27828 34788986
On and off phenomenon 80.09 11.62 72 140045 2425 34814389
Drug dependence 79.91 11.62 246 139871 23971 34792843
Sinusitis 79.71 11.62 33 140084 41369 34775445
Myocarditis 79.50 11.62 172 139945 13510 34803304
Pneumonitis 79.47 11.62 19 140098 33859 34782955
Coma scale abnormal 79.45 11.62 89 140028 3919 34812895
Herpes zoster 79.32 11.62 20 140097 34379 34782435
Ascites 79.16 11.62 44 140073 46527 34770287
Dysphoria 79.07 11.62 69 140048 2233 34814581
Drug screen positive 78.92 11.62 88 140029 3855 34812959
Pneumonia aspiration 78.02 11.62 354 139763 41549 34775265
Dyspnoea exertional 77.84 11.62 38 140079 43241 34773573
Loss of consciousness 77.41 11.62 582 139535 82085 34734729
Agitation neonatal 76 11.62 50 140067 1046 34815768
Delusional disorder, persecutory type 75.86 11.62 33 140084 283 34816531
Thrombosis 75.71 11.62 55 140062 50403 34766411
Cogwheel rigidity 75.58 11.62 54 140063 1298 34815516
Depressed mood 75.03 11.62 208 139909 19109 34797705
Epistaxis 74.55 11.62 74 140043 58177 34758637
Abdominal pain 74.33 11.62 370 139747 163248 34653566
Bruxism 74.12 11.62 59 140058 1676 34815138
Mucosal inflammation 74.01 11.62 31 140086 38591 34778223
Coronary artery disease 73.33 11.62 52 140065 48253 34768561
Hyperthermia 73.29 11.62 143 139974 10434 34806380
Prostate cancer 72.55 11.62 34 140083 39615 34777199
Akinesia 72.08 11.62 64 140053 2120 34814694
Stupor 71.12 11.62 72 140045 2819 34813995
Antipsychotic drug level above therapeutic 70.66 11.62 50 140067 1183 34815631
Unresponsive to stimuli 70.50 11.62 257 139860 27312 34789502
Accidental death 69.44 11.62 66 140051 2390 34814424
Thinking abnormal 69.12 11.62 103 140014 6034 34810780
Cytomegalovirus infection 69.00 11.62 11 140106 26124 34790690
Hyperkinesia 68.93 11.62 57 140060 1711 34815103
Homicidal ideation 68.19 11.62 68 140049 2614 34814200
Acute myocardial infarction 67.87 11.62 69 140048 53650 34763164
Renal failure 67.79 11.62 281 139836 130276 34686538
Small for dates baby 67.45 11.62 81 140036 3846 34812968
Neonatal behavioural syndrome 67.04 11.62 24 140093 114 34816700
Colitis 66.60 11.62 34 140083 37716 34779098
Renal impairment 66.53 11.62 178 139939 94335 34722479
Weight decreased 66.36 11.62 424 139693 175877 34640937
Neonatal respiratory distress syndrome 65.70 11.62 81 140036 3953 34812861
Cardio-respiratory arrest 64.65 11.62 411 139706 54862 34761952
Multiple drug therapy 63.97 11.62 33 140084 428 34816386
Malaise 63.92 11.62 459 139658 185366 34631448
Anaphylactic reaction 63.40 11.62 25 140092 32276 34784538
Neoplasm progression 63.36 11.62 9 140108 23291 34793523
Peripheral swelling 62.74 11.62 133 139984 76408 34740406
Major depression 62.23 11.62 84 140033 4488 34812326
Chills 62.20 11.62 146 139971 80897 34735917
Arthritis 61.95 11.62 24 140093 31322 34785492
Personality change 61.86 11.62 89 140028 5050 34811764
Poor quality sleep 61.36 11.62 115 140002 8141 34808673
Vomiting 60.80 11.62 667 139450 246954 34569860
Hypertriglyceridaemia 60.72 11.62 116 140001 8332 34808482
Multiple organ dysfunction syndrome 60.32 11.62 136 139981 76430 34740384
Pneumocystis jirovecii pneumonia 60.22 11.62 5 140112 19705 34797109
Basal cell carcinoma 60.03 11.62 5 140112 19653 34797161
Visceral congestion 59.55 11.62 35 140082 595 34816219
Chronic obstructive pulmonary disease 59.37 11.62 65 140052 48853 34767961
Myelosuppression 58.55 11.62 5 140112 19260 34797554
Cellulitis 58.26 11.62 76 140041 52875 34763939
Loss of libido 58.16 11.62 61 140056 2491 34814323
Clonus 57.85 11.62 63 140054 2687 34814127
Arthropathy 57.65 11.62 18 140099 26889 34789925
Urinary retention 57.03 11.62 292 139825 35996 34780818
Malignant catatonia 56.81 11.62 25 140092 221 34816593
Hypothermia 56.69 11.62 130 139987 10618 34806196
Wrong product administered 56.50 11.62 87 140030 5247 34811567
Erythema 56.06 11.62 176 139941 88604 34728210
Hypotonia neonatal 55.88 11.62 45 140072 1300 34815514
Abulia 55.83 11.62 33 140084 567 34816247
Productive cough 55.71 11.62 42 140075 37771 34779043
Excessive eye blinking 55.33 11.62 32 140085 527 34816287
Logorrhoea 55.31 11.62 58 140059 2368 34814446
Torticollis 55.29 11.62 42 140075 1112 34815702
Chest discomfort 55.27 11.62 83 140034 54447 34762367
Abdominal discomfort 55.10 11.62 97 140020 59738 34757076
Stoma site erythema 54.54 11.62 37 140080 816 34815998
Blood triglycerides increased 54.53 11.62 152 139965 14007 34802807
Hypokinesia 54.32 11.62 114 140003 8766 34808048
Influenza 53.91 11.62 72 140045 49594 34767220
Epilepsy 53.79 11.62 199 139918 21296 34795518
Slow speech 53.77 11.62 42 140075 1160 34815654
Affect lability 53.72 11.62 70 140047 3613 34813201
Myoclonus 53.71 11.62 155 139962 14570 34802244
Blood pressure increased 53.30 11.62 178 139939 87924 34728890
Sleep-related eating disorder 52.63 11.62 25 140092 268 34816546
Urinary incontinence 52.59 11.62 181 139936 18693 34798121
Sexually inappropriate behaviour 52.52 11.62 30 140087 482 34816332
Haemorrhage 52.25 11.62 78 140039 51292 34765522
Faecaloma 51.83 11.62 84 140033 5293 34811521
Colitis ischaemic 51.67 11.62 93 140024 6382 34810432
Tension 51.39 11.62 53 140064 2122 34814692
Disturbance in attention 51.16 11.62 223 139894 25722 34791092
Freezing phenomenon 50.67 11.62 45 140072 1491 34815323
Antipsychotic drug level increased 49.57 11.62 69 140048 3796 34813018
Cytokine release syndrome 49.56 11.62 15 140102 22862 34793952
Brugada syndrome 49.45 11.62 34 140083 767 34816047
Somnambulism 48.93 11.62 61 140056 3011 34813803
Drooling 48.90 11.62 64 140053 3318 34813496
Reduced facial expression 48.54 11.62 38 140079 1053 34815761
Hypersensitivity 48.40 11.62 108 140009 60927 34755887
Medication error 48.34 11.62 217 139900 25348 34791466
Cardiac failure 47.58 11.62 196 139921 91052 34725762
Septic shock 47.06 11.62 140 139977 71694 34745120
Oedema 46.96 11.62 69 140048 45672 34771142
Hypoaesthesia 46.89 11.62 111 140006 61333 34755481
Psoriatic arthropathy 46.64 11.62 11 140106 19787 34797027
Stereotypy 46.38 11.62 32 140085 726 34816088
Respiratory depression 46.32 11.62 157 139960 16088 34800726
Osteonecrosis of jaw 46.17 11.62 8 140109 17881 34798933
Asthma 46.13 11.62 62 140055 42594 34774220
Aspiration 46.07 11.62 130 139987 12064 34804750
Derealisation 45.74 11.62 29 140088 568 34816246
Oppositional defiant disorder 45.42 11.62 28 140089 521 34816293
Diet refusal 45.37 11.62 23 140094 287 34816527
Stoma site discharge 45.00 11.62 38 140079 1175 34815639
Blood creatinine increased 44.69 11.62 212 139905 94764 34722050
Anticonvulsant drug level above therapeutic 44.60 11.62 30 140087 652 34816162
Dyslipidaemia 44.49 11.62 95 140022 7393 34809421
Palmar-plantar erythrodysaesthesia syndrome 44.49 11.62 7 140110 16788 34800026
Lung disorder 44.47 11.62 44 140073 34652 34782162
Death 44.15 11.62 1237 138880 396812 34420002
Pulmonary fibrosis 43.77 11.62 10 140107 18386 34798428
Trismus 43.73 11.62 52 140065 2443 34814371
Cerebrovascular accident 43.70 11.62 183 139934 84628 34732186
Chest pain 43.59 11.62 313 139804 126449 34690365
Acute myeloid leukaemia 43.34 11.62 10 140107 18260 34798554
Decreased eye contact 42.88 11.62 26 140091 469 34816345
Judgement impaired 42.63 11.62 28 140089 584 34816230
Psychiatric symptom 42.52 11.62 61 140056 3452 34813362
Rash pruritic 42.22 11.62 28 140089 26913 34789901
Vein of Galen aneurysmal malformation 42.18 11.62 11 140106 11 34816803
Granulocytopenia 42.15 11.62 86 140031 6481 34810333
Gambling disorder 42.04 11.62 42 140075 1618 34815196
Oropharyngeal spasm 41.92 11.62 18 140099 149 34816665
Diabetic ketoacidosis 41.87 11.62 163 139954 17869 34798945
Synovitis 41.81 11.62 4 140113 14062 34802752
Paradoxical drug reaction 41.75 11.62 59 140058 3292 34813522
Illusion 41.62 11.62 31 140086 796 34816018
Chronic kidney disease 41.49 11.62 63 140054 41147 34775667
Swelling 41.48 11.62 66 140051 42300 34774514
Bronchopulmonary aspergillosis 41.45 11.62 5 140112 14654 34802160
Trichoglossia 41.30 11.62 22 140095 306 34816508
Bone marrow failure 41.19 11.62 34 140083 29219 34787595
Myelodysplastic syndrome 40.88 11.62 13 140104 19195 34797619
Full blood count decreased 40.77 11.62 11 140106 18077 34798737
Atrial septal defect 40.75 11.62 91 140026 7301 34809513
Grimacing 40.73 11.62 21 140096 272 34816542
Suspiciousness 40.62 11.62 22 140095 317 34816497
Accidental overdose 40.39 11.62 174 139943 19966 34796848
Personality disorder 40.09 11.62 35 140082 1133 34815681
Otospondylomegaepiphyseal dysplasia 40.05 11.62 16 140101 108 34816706
Upper respiratory tract infection 40.03 11.62 44 140073 33015 34783799
Hepatic failure 39.61 11.62 48 140069 34483 34782331
Tic 39.60 11.62 45 140072 2013 34814801
Prescription drug used without a prescription 39.60 11.62 46 140071 2108 34814706
Nephrolithiasis 39.41 11.62 38 140079 30295 34786519
Haematuria 39.36 11.62 89 140028 49977 34766837
Skin ulcer 39.20 11.62 20 140097 22196 34794618
Blood bilirubin increased 39.08 11.62 58 140059 38238 34778576
Poverty of speech 38.95 11.62 19 140098 217 34816597
Haemoptysis 38.75 11.62 50 140067 34956 34781858
Sudden cardiac death 38.69 11.62 60 140057 3641 34813173
Product substitution issue 38.51 11.62 108 140009 9987 34806827
Flight of ideas 38.43 11.62 22 140095 355 34816459
Wheezing 38.22 11.62 67 140050 41335 34775479
Musculoskeletal pain 38.20 11.62 43 140074 31920 34784894
International normalised ratio increased 38.13 11.62 83 140034 47244 34769570
Psychosexual disorder 38.08 11.62 15 140102 97 34816717
Panic attack 38.05 11.62 103 140014 9329 34807485
Anxiolytic therapy 37.90 11.62 13 140104 53 34816761
Bronchitis 37.75 11.62 69 140048 41894 34774920
Embolism venous 37.74 11.62 38 140079 1478 34815336
Compartment syndrome 37.40 11.62 53 140064 2965 34813849
Dystonic tremor 37.25 11.62 18 140099 201 34816613
Hypocalcaemia 37.05 11.62 26 140091 24263 34792551
Prostatic specific antigen increased 36.95 11.62 7 140110 14673 34802141
Manic symptom 36.84 11.62 15 140102 107 34816707
Diverticulitis 36.83 11.62 17 140100 19987 34796827
Large for dates baby 36.63 11.62 30 140087 888 34815926
Jealous delusion 36.63 11.62 20 140097 293 34816521
Hypomagnesaemia 36.61 11.62 21 140096 21830 34794984
Substance abuse 36.58 11.62 89 140028 7552 34809262
Feeling jittery 36.52 11.62 61 140056 3942 34812872
Libido increased 36.48 11.62 29 140088 822 34815992
Leukopenia 36.46 11.62 399 139718 62457 34754357
Dehydration 36.42 11.62 339 139778 129630 34687184
Electrocardiogram abnormal 36.33 11.62 100 140017 9147 34807667
Feelings of worthlessness 36.28 11.62 20 140097 299 34816515
Drug therapy enhancement 36.27 11.62 13 140104 62 34816752
Flushing 36.20 11.62 46 140071 32374 34784440
Device related infection 36.10 11.62 12 140105 17225 34799589
Gout 36.01 11.62 16 140101 19237 34797577
Overweight 35.81 11.62 41 140076 1849 34814965
Incoherent 35.59 11.62 64 140053 4388 34812426
Tumour lysis syndrome 35.51 11.62 12 140105 17047 34799767
Upper gastrointestinal haemorrhage 35.51 11.62 30 140087 25488 34791326
Abdominal distension 35.49 11.62 118 139999 58374 34758440
Electrocardiogram QT interval abnormal 35.48 11.62 14 140103 91 34816723
Muscular weakness 35.30 11.62 161 139956 72736 34744078
Pleurothotonus 35.25 11.62 33 140084 1172 34815642
Alcoholism 35.18 11.62 51 140066 2914 34813900
Inflammation 34.99 11.62 37 140080 28258 34788556
Neonatal seizure 34.97 11.62 23 140094 481 34816333
Temperature regulation disorder 34.90 11.62 27 140090 735 34816079
Bladder cancer 34.67 11.62 11 140106 16267 34800547
Impulsive behaviour 34.55 11.62 43 140074 2119 34814695
Device dislocation 34.53 11.62 77 140040 6172 34810642
Mood altered 34.37 11.62 96 140021 8856 34807958
Hypertonia 33.90 11.62 61 140056 4185 34812629
Brachial plexopathy 33.69 11.62 12 140105 56 34816758
Hyperammonaemia 33.56 11.62 77 140040 6290 34810524
Behaviour disorder 33.55 11.62 66 140051 4844 34811970
Appendicitis 33.38 11.62 9 140108 14798 34802016
Alcohol abuse 33.21 11.62 64 140053 4626 34812188
Hangover 33.11 11.62 30 140087 1021 34815793
Vasoplegia syndrome 33.06 11.62 39 140078 1817 34814997
Haemophagocytic lymphohistiocytosis 33.05 11.62 6 140111 12967 34803847
Fall 33.04 11.62 1055 139062 201830 34614984
Squamous cell carcinoma of skin 32.59 11.62 3 140114 10878 34805936
Neonatal toxicity 32.53 11.62 10 140107 26 34816788
Muscle twitching 32.48 11.62 103 140014 10195 34806619
Oropharyngeal pain 32.23 11.62 58 140059 35427 34781387
Dementia with Lewy bodies 32.02 11.62 25 140092 690 34816124
Bipolar I disorder 32.00 11.62 26 140091 761 34816053
Hypersomnia 32.00 11.62 116 140001 12291 34804523
Antipsychotic drug level decreased 31.98 11.62 29 140088 988 34815826
Blister 31.65 11.62 27 140090 22831 34793983
Oral discharge 31.60 11.62 14 140103 126 34816688
Hyperosmolar state 31.49 11.62 20 140097 393 34816421
Staring 31.49 11.62 34 140083 1436 34815378
Coordination abnormal 31.37 11.62 84 140033 7560 34809254
Gastrointestinal disorder 31.27 11.62 55 140062 33893 34782921
Lymphadenopathy 31.15 11.62 41 140076 28422 34788392
Pseudomonas infection 30.96 11.62 6 140111 12376 34804438
Injection site pain 30.93 11.62 69 140048 38936 34777878
Paraesthesia 30.90 11.62 142 139975 64030 34752784
Neoplasm malignant 30.77 11.62 21 140096 19884 34796930
Heart rate decreased 30.56 11.62 50 140067 31695 34785119
Transplant rejection 30.47 11.62 3 140114 10308 34806506
Distributive shock 30.43 11.62 31 140086 1223 34815591
Skin lesion 30.33 11.62 26 140091 21935 34794879
Anticholinergic syndrome 30.12 11.62 31 140086 1238 34815576
Tachyphrenia 30.12 11.62 31 140086 1238 34815576
Drug level increased 30.09 11.62 171 139946 21925 34794889
Hallucinations, mixed 30.09 11.62 45 140072 2644 34814170
Rebound effect 30.01 11.62 50 140067 3224 34813590
Galactorrhoea 29.92 11.62 20 140097 430 34816384
Rectal haemorrhage 29.68 11.62 74 140043 40175 34776639
Exposure via ingestion 29.58 11.62 40 140077 2141 34814673
Screaming 29.49 11.62 33 140084 1451 34815363
Tremor neonatal 29.49 11.62 19 140098 383 34816431
Cholecystitis 29.36 11.62 4 140113 10684 34806130
Cholestasis 29.30 11.62 39 140078 26909 34789905
Withdrawal arrhythmia 29.30 11.62 10 140107 40 34816774
Delusional disorder, unspecified type 29.29 11.62 24 140093 711 34816103
Congestive cardiomyopathy 29.29 11.62 81 140036 7429 34809385
Rash maculo-papular 29.12 11.62 43 140074 28408 34788406
Atrial flutter 29.04 11.62 13 140104 15561 34801253
Dependence 28.95 11.62 29 140088 1121 34815693
Angioedema 28.92 11.62 67 140050 37307 34779507
Dacryostenosis congenital 28.92 11.62 10 140107 42 34816772
COVID-19 pneumonia 28.87 11.62 16 140101 16951 34799863
Negativism 28.77 11.62 19 140098 400 34816414
Neonatal tachypnoea 28.77 11.62 14 140103 159 34816655
Resting tremor 28.72 11.62 23 140094 659 34816155
Gynaecomastia 28.68 11.62 98 140019 10082 34806732
Fungal infection 28.63 11.62 14 140103 15921 34800893
Nightmare 28.60 11.62 124 139993 14267 34802547
Dry skin 28.54 11.62 51 140066 31236 34785578
Acute psychosis 28.41 11.62 36 140081 1807 34815007
Hypoacusis 28.28 11.62 15 140102 16286 34800528
Pyromania 28.02 11.62 10 140107 47 34816767
Localised infection 27.93 11.62 18 140099 17569 34799245
Rebound psychosis 27.88 11.62 14 140103 171 34816643
Impulse-control disorder 27.71 11.62 30 140087 1271 34815543
Excessive masturbation 27.57 11.62 12 140105 103 34816711
Hypoglycaemia neonatal 27.52 11.62 36 140081 1865 34814949
Haematochezia 27.46 11.62 95 140022 46439 34770375
Lung neoplasm malignant 27.36 11.62 18 140099 17377 34799437
Dysphonia 27.35 11.62 32 140085 23351 34793463
Stoma site hypergranulation 27.32 11.62 14 140103 179 34816635
Blood pressure systolic increased 27.29 11.62 31 140086 22921 34793893
Gaze palsy 27.28 11.62 34 140083 1678 34815136
Tachycardia foetal 27.13 11.62 17 140100 326 34816488
Antisocial behaviour 26.85 11.62 18 140099 389 34816425
Acute respiratory failure 26.81 11.62 52 140065 30876 34785938
Oesophageal carcinoma 26.74 11.62 3 140114 9301 34807513
Dyspepsia 26.72 11.62 68 140049 36664 34780150
Coagulopathy 26.64 11.62 24 140093 19765 34797049
Patent ductus arteriosus 26.54 11.62 48 140069 3306 34813508
Bacteraemia 26.44 11.62 24 140093 19693 34797121
Hyperammonaemic encephalopathy 26.16 11.62 39 140078 2285 34814529
Self-injurious ideation 26.12 11.62 33 140084 1651 34815163
Obstructive airways disorder 25.80 11.62 15 140102 15479 34801335
Enuresis 25.80 11.62 39 140078 2314 34814500
Nonspecific reaction 25.71 11.62 30 140087 1381 34815433
Emotional disorder 25.70 11.62 65 140052 5651 34811163
Troponin increased 25.67 11.62 102 140015 11287 34805527
Renal disorder 25.60 11.62 39 140078 25441 34791373
Illness anxiety disorder 25.52 11.62 13 140104 164 34816650
Stoma site infection 25.28 11.62 23 140094 787 34816027
Hypervolaemia 25.25 11.62 25 140092 19684 34797130
Rhinorrhoea 25.11 11.62 40 140077 25628 34791186
Encephalopathy neonatal 25.10 11.62 9 140108 43 34816771
Meconium aspiration syndrome 25.10 11.62 9 140108 43 34816771
False positive investigation result 25.04 11.62 18 140099 437 34816377
Pulmonary mass 25.00 11.62 10 140107 12802 34804012
Dissociation 24.94 11.62 32 140085 1626 34815188
Laboratory test abnormal 24.84 11.62 27 140090 20364 34796450
Incontinence 24.75 11.62 65 140052 5782 34811032
Schizophreniform disorder 24.72 11.62 10 140107 70 34816744
Cholelithiasis 24.67 11.62 29 140088 21119 34795695
Proteinuria 24.63 11.62 23 140094 18619 34798195
Opisthotonus 24.62 11.62 18 140099 449 34816365
Status epilepticus 24.54 11.62 108 140009 12506 34804308
Refusal of treatment by patient 24.50 11.62 59 140058 4973 34811841
Osteoarthritis 24.41 11.62 28 140089 20614 34796200
Dizziness 24.40 11.62 678 139439 217843 34598971
Maternal drugs affecting foetus 24.36 11.62 51 140066 3914 34812900
Tubulointerstitial nephritis 24.35 11.62 29 140088 20995 34795819
Staphylococcal infection 24.34 11.62 60 140057 32700 34784114
Peritonitis 24.33 11.62 18 140099 16347 34800467
Acute coronary syndrome 24.19 11.62 12 140105 13533 34803281
Inappropriate affect 24.00 11.62 21 140096 682 34816132
Blunted affect 23.94 11.62 16 140101 344 34816470
Inappropriate antidiuretic hormone secretion 23.91 11.62 108 140009 12645 34804169
Skin exfoliation 23.88 11.62 46 140071 27386 34789428
Urine alcohol test positive 23.84 11.62 8 140109 30 34816784
Blepharospasm 23.82 11.62 26 140091 1112 34815702
Postmortem blood drug level increased 23.71 11.62 14 140103 240 34816574
Myalgia 23.71 11.62 219 139898 83891 34732923
Amnesia 23.70 11.62 185 139932 26378 34790436
Hepatitis 23.62 11.62 37 140080 23867 34792947
Full blood count abnormal 23.55 11.62 24 140093 18644 34798170
Stoma site inflammation 23.49 11.62 18 140099 483 34816331
Choreoathetosis 23.48 11.62 25 140092 1039 34815775
Intentional medical device removal by patient 23.47 11.62 15 140102 298 34816516
Penile haemorrhage 23.45 11.62 20 140097 627 34816187
Autonomic nervous system imbalance 23.44 11.62 39 140078 2512 34814302
Neuralgia 23.28 11.62 16 140101 15097 34801717
Nervousness 23.08 11.62 106 140011 12500 34804314
Feeling guilty 23.04 11.62 15 140102 308 34816506
Pulmonary hypertension 23.04 11.62 30 140087 20894 34795920
Muscle spasms 23.03 11.62 191 139926 74810 34742004
Necrotising colitis 23.02 11.62 25 140092 1063 34815751
Hypercalcaemia 23.01 11.62 17 140100 15451 34801363
Liver function test increased 23.00 11.62 15 140102 14550 34802264
Alcohol poisoning 23.00 11.62 47 140070 3546 34813268
Penis injury 22.97 11.62 14 140103 255 34816559
Sudden death 22.96 11.62 121 139996 15080 34801734
Ileus paralytic 22.72 11.62 64 140053 5933 34810881
Generalised tonic-clonic seizure 22.64 11.62 154 139963 21020 34795794
Crying 22.64 11.62 63 140054 5799 34811015
Osteonecrosis 22.63 11.62 16 140101 14874 34801940
Fluid retention 22.62 11.62 46 140071 26841 34789973
pH body fluid decreased 22.62 11.62 5 140112 0 34816814
Parkinsonian rest tremor 22.60 11.62 11 140106 125 34816689
Hypophosphataemia 22.53 11.62 8 140109 11018 34805796
Neck pain 22.51 11.62 42 140075 25307 34791507
Stoma site pain 22.49 11.62 20 140097 664 34816150
Enteritis 22.48 11.62 3 140114 8139 34808675
Lymphoma 22.45 11.62 11 140106 12496 34804318
Osteomyelitis 22.41 11.62 19 140098 16117 34800697
Renal tubular necrosis 22.35 11.62 18 140099 15662 34801152
Spasmodic dysphonia 22.32 11.62 13 140104 217 34816597
Metastases to bone 22.30 11.62 10 140107 11960 34804854
Blood urea increased 22.25 11.62 56 140061 30308 34786506
Mood swings 22.21 11.62 76 140041 7825 34808989
Affective disorder 22.18 11.62 52 140065 4308 34812506
Cholangitis 22.18 11.62 4 140113 8685 34808129
Cerebral amyloid angiopathy 22.15 11.62 11 140106 131 34816683
Ataxia 22.12 11.62 112 140005 13741 34803073
Gastrointestinal necrosis 22.12 11.62 45 140072 3384 34813430
Encephalitis toxic 22.09 11.62 14 140103 274 34816540
Treatment failure 22.08 11.62 104 140013 46593 34770221
Tooth disorder 22.05 11.62 8 140109 10874 34805940
Finnegan score increased 22.04 11.62 7 140110 21 34816793
Product communication issue 21.92 11.62 16 140101 398 34816416
Ventricular tachycardia 21.92 11.62 46 140071 26533 34790281
Blood lactic acid increased 21.87 11.62 68 140049 6660 34810154
Hypospadias 21.84 11.62 43 140074 3158 34813656
Drug diversion 21.82 11.62 22 140095 857 34815957
Dysgeusia 21.73 11.62 46 140071 26451 34790363
Blood cholesterol increased 21.73 11.62 149 139968 20394 34796420
Incorrect route of product administration 21.62 11.62 117 140000 14728 34802086
Abdominal pain upper 21.53 11.62 183 139934 71307 34745507
Choking 21.48 11.62 56 140061 4959 34811855
Water intoxication 21.44 11.62 16 140101 412 34816402
Bone pain 21.43 11.62 31 140086 20655 34796159
Pancreatitis 21.24 11.62 244 139873 38647 34778167
Slow response to stimuli 21.24 11.62 21 140096 799 34816015
Psoriasis 21.08 11.62 82 140035 38730 34778084
Distractibility 21.05 11.62 15 140102 359 34816455
Verbal abuse 20.84 11.62 12 140105 196 34816618
Brain injury 20.82 11.62 63 140054 6079 34810735
Type 1 diabetes mellitus 20.81 11.62 50 140067 4208 34812606
Squamous cell carcinoma 20.74 11.62 10 140107 11465 34805349
Hepatic cancer 20.71 11.62 4 140113 8271 34808543
Cerebral infarction 20.62 11.62 50 140067 27405 34789409
Congenital cerebrovascular anomaly 20.60 11.62 6 140111 12 34816802
Penoscrotal fusion 20.60 11.62 6 140111 12 34816802
Epidermolysis bullosa 20.51 11.62 10 140107 114 34816700
Lower respiratory tract infection 20.46 11.62 62 140055 31575 34785239
Abnormal clotting factor 20.41 11.62 9 140108 80 34816734
Metastases to lung 20.39 11.62 6 140111 9314 34807500
Immune reconstitution inflammatory syndrome 20.37 11.62 5 140112 8754 34808060
Melaena 20.35 11.62 73 140044 35307 34781507
Newborn persistent pulmonary hypertension 20.29 11.62 10 140107 117 34816697
Erectile dysfunction 20.26 11.62 147 139970 20490 34796324
Pulmonary haemorrhage 20.17 11.62 8 140109 10296 34806518
Skin cancer 20.15 11.62 8 140109 10289 34806525
Clostridium difficile colitis 20.09 11.62 20 140097 15710 34801104
Toxic epidermal necrolysis 20.00 11.62 35 140082 21611 34795203
Knee arthroplasty 19.95 11.62 3 140114 7441 34809373
Salivary gland calculus 19.94 11.62 9 140108 85 34816729
Intentional product use issue 19.91 11.62 149 139968 59667 34757147
Gastrointestinal hypomotility 19.87 11.62 23 140094 1050 34815764
Renal injury 19.87 11.62 10 140107 11185 34805629
Pyramidal tract syndrome 19.72 11.62 12 140105 218 34816596
Diffuse large B-cell lymphoma 19.68 11.62 3 140114 7367 34809447
Hypersexuality 19.67 11.62 27 140090 1466 34815348
Brain hypoxia 19.54 11.62 14 140103 338 34816476
Lymphopenia 19.49 11.62 22 140095 16313 34800501
Influenza like illness 19.46 11.62 52 140065 27582 34789232
Impaired self-care 19.45 11.62 25 140092 1273 34815541
Junctional ectopic tachycardia 19.41 11.62 6 140111 16 34816798
Visceral pain 19.31 11.62 8 140109 60 34816754
Interleukin level increased 19.23 11.62 10 140107 132 34816682
Device kink 19.18 11.62 15 140102 415 34816399
Polydipsia 19.17 11.62 46 140071 3869 34812945
Respiratory failure 19.08 11.62 313 139804 108259 34708555
Hyperhidrosis 19.07 11.62 417 139700 75275 34741539
Obsessive thoughts 18.93 11.62 19 140098 736 34816078
Hyperdynamic left ventricle 18.92 11.62 11 140106 183 34816631
IVth nerve disorder 18.90 11.62 6 140111 18 34816796
Renal cancer 18.82 11.62 4 140113 7731 34809083
Ketoacidosis 18.81 11.62 48 140069 4195 34812619
Hot flush 18.78 11.62 27 140090 18039 34798775
Language disorder 18.77 11.62 33 140084 2223 34814591
Haemangioma congenital 18.75 11.62 16 140101 502 34816312
Alcohol use 18.71 11.62 41 140076 3247 34813567
Subarachnoid haemorrhage 18.65 11.62 14 140103 12621 34804193
Hyperglycaemia 18.65 11.62 241 139876 39239 34777575
Mental status changes 18.63 11.62 234 139883 37849 34778965
Ejection fraction decreased 18.59 11.62 30 140087 19124 34797690
Flashback 18.59 11.62 10 140107 142 34816672
Drug dispensed to wrong patient 18.59 11.62 16 140101 508 34816306
Painful erection 18.58 11.62 12 140105 243 34816571
Parkinsonian gait 18.54 11.62 16 140101 510 34816304
Alcohol interaction 18.52 11.62 38 140079 2875 34813939
Talipes 18.48 11.62 30 140087 1893 34814921
Myoclonic epilepsy 18.47 11.62 23 140094 1134 34815680
Waxy flexibility 18.43 11.62 9 140108 103 34816711
Substance use 18.39 11.62 18 140099 676 34816138
Hepatic encephalopathy 18.38 11.62 19 140098 14666 34802148
Injection site erythema 18.34 11.62 22 140095 15877 34800937
Posturing 18.33 11.62 16 140101 518 34816296
Leukaemia 18.30 11.62 50 140067 4553 34812261
Perseveration 18.28 11.62 9 140108 105 34816709
Acoustic stimulation tests abnormal 18.25 11.62 8 140109 70 34816744
Attention deficit hyperactivity disorder 18.22 11.62 35 140082 2524 34814290
Infant irritability 18.21 11.62 7 140110 42 34816772
Product storage error 18.19 11.62 5 140112 8117 34808697
Myasthenia gravis 18.14 11.62 3 140114 6937 34809877
Self-medication 18.07 11.62 36 140081 2667 34814147
Phaeochromocytoma malignant 18.06 11.62 8 140109 72 34816742
Embedded device 18.00 11.62 13 140104 318 34816496
Therapy interrupted 17.98 11.62 17 140100 13680 34803134
Mutism 17.95 11.62 20 140097 875 34815939
Hepatotoxicity 17.87 11.62 37 140080 21448 34795366
Hernia 17.86 11.62 8 140109 9575 34807239
Lip swelling 17.76 11.62 23 140094 16057 34800757
Camptocormia 17.71 11.62 10 140107 157 34816657
Kidney duplex 17.70 11.62 14 140103 394 34816420
Stoma site induration 17.68 11.62 7 140110 46 34816768
Eye movement disorder 17.59 11.62 46 140071 4081 34812733
Acute generalised exanthematous pustulosis 17.55 11.62 3 140114 6773 34810041
Large intestine polyp 17.49 11.62 5 140112 7909 34808905
Tri-iodothyronine decreased 17.43 11.62 9 140108 117 34816697
Haemorrhage intracranial 17.41 11.62 23 140094 15923 34800891
Cardiac failure chronic 17.37 11.62 5 140112 7874 34808940
Binge eating 17.36 11.62 9 140108 118 34816696
Blood urine present 17.33 11.62 11 140106 10823 34805991
Hypoalbuminaemia 17.32 11.62 14 140103 12160 34804654
Respiratory acidosis 17.31 11.62 52 140065 4998 34811816
Orthostatic hypertension 17.29 11.62 12 140105 275 34816539
Delusional perception 17.27 11.62 10 140107 165 34816649
Iron deficiency anaemia 17.20 11.62 10 140107 10319 34806495
Cryptorchism 17.16 11.62 30 140087 2011 34814803
Discomfort 17.15 11.62 31 140086 18907 34797907
Lymphocyte count decreased 17.14 11.62 41 140076 22581 34794233
Ageusia 17.13 11.62 10 140107 10298 34806516
Emotional distress 17.10 11.62 111 140006 14915 34801899
Angina unstable 17.09 11.62 13 140104 11640 34805174
Apraxia 17.05 11.62 24 140093 1334 34815480
Panic disorder 17.01 11.62 23 140094 1231 34815583
Intercepted medication error 16.99 11.62 15 140102 493 34816321
Motor dysfunction 16.97 11.62 64 140053 6910 34809904
Retrograde ejaculation 16.96 11.62 14 140103 419 34816395
Colitis ulcerative 16.87 11.62 25 140092 16495 34800319
Pulmonary arterial hypertension 16.76 11.62 7 140110 8732 34808082
Faeces discoloured 16.72 11.62 21 140096 14857 34801957
Compulsions 16.68 11.62 11 140106 231 34816583
Pneumothorax 16.63 11.62 32 140085 19060 34797754
Frequent bowel movements 16.63 11.62 16 140101 12771 34804043
Somatic symptom disorder 16.62 11.62 17 140100 674 34816140
Postural orthostatic tachycardia syndrome 16.58 11.62 8 140109 89 34816725
Angina pectoris 16.56 11.62 67 140050 31296 34785518
Erection increased 16.52 11.62 15 140102 512 34816302
Cytopenia 16.46 11.62 16 140101 12707 34804107
Subgaleal haematoma 16.43 11.62 8 140109 91 34816723
Vascular stenosis 16.42 11.62 10 140107 182 34816632
Anaphylactic shock 16.40 11.62 24 140093 15917 34800897
Flatulence 16.40 11.62 38 140079 21160 34795654
Delirium febrile 16.35 11.62 6 140111 31 34816783
Pneumonitis chemical 16.32 11.62 10 140107 184 34816630
Haemolysis 16.32 11.62 6 140111 8088 34808726
Abscess 16.31 11.62 14 140103 11803 34805011
Convulsive threshold lowered 16.25 11.62 15 140102 523 34816291
Psychotic behaviour 16.25 11.62 17 140100 692 34816122
Shock haemorrhagic 16.23 11.62 13 140104 11341 34805473
Psychotic disorder due to a general medical condition 16.19 11.62 7 140110 59 34816755
Contraindication to medical treatment 16.19 11.62 17 140100 695 34816119
Polymerase chain reaction 16.13 11.62 8 140109 95 34816719
Lactic acidosis 16.11 11.62 78 140039 34694 34782120
Borderline personality disorder 16.10 11.62 13 140104 377 34816437
Enterocolitis 16.10 11.62 6 140111 8020 34808794
Eye pruritus 16.06 11.62 5 140112 7484 34809330
Patient isolation 16.04 11.62 6 140111 33 34816781
Postoperative respiratory failure 16.01 11.62 9 140108 140 34816674
Drug withdrawal headache 16.00 11.62 5 140112 14 34816800
Transposition of the great vessels 15.99 11.62 14 140103 455 34816359
Iatrogenic injury 15.99 11.62 19 140098 892 34815922
Carbon monoxide poisoning 15.98 11.62 8 140109 97 34816717
Respiratory distress 15.95 11.62 81 140036 35584 34781230
Visual acuity reduced 15.95 11.62 25 140092 16124 34800690
Hallucination, tactile 15.92 11.62 12 140105 314 34816500
Multiple cardiac defects 15.90 11.62 7 140110 62 34816752
Bundle branch block right 15.89 11.62 66 140051 7450 34809364
Swelling face 15.87 11.62 44 140073 23061 34793753
Leukopenia neonatal 15.87 11.62 4 140113 3 34816811
Transient ischaemic attack 15.87 11.62 57 140060 27556 34789258
Hepatitis cholestatic 15.84 11.62 6 140111 7941 34808873
Fistula 15.72 11.62 4 140113 6836 34809978
Wrong patient 15.68 11.62 9 140108 146 34816668
Laryngeal dyspnoea 15.63 11.62 8 140109 102 34816712
Hyperarousal 15.61 11.62 6 140111 36 34816778
Bacterial parotitis 15.61 11.62 6 140111 36 34816778
Memory impairment 15.52 11.62 252 139865 43066 34773748
Eosinophilic pleural effusion 15.52 11.62 11 140106 261 34816553
Injection site haemorrhage 15.51 11.62 10 140107 9758 34807056
Anamnestic reaction 15.47 11.62 6 140111 37 34816777
Sexual abuse 15.47 11.62 9 140108 150 34816664
Optic discs blurred 15.43 11.62 7 140110 67 34816747
Congenital cystic kidney disease 15.42 11.62 13 140104 401 34816413
Hostility 15.40 11.62 18 140099 830 34815984
Homicide 15.37 11.62 19 140098 930 34815884
Pressure of speech 15.34 11.62 14 140103 481 34816333
Intermittent explosive disorder 15.34 11.62 4 140113 4 34816810
Myocardial ischaemia 15.32 11.62 29 140088 17379 34799435
Blood pressure fluctuation 15.26 11.62 51 140066 25198 34791616
Anomaly of external ear congenital 15.23 11.62 8 140109 108 34816706
Sluggishness 15.20 11.62 38 140079 3279 34813535
Alanine aminotransferase increased 15.20 11.62 230 139887 80585 34736229
Conduction disorder 15.19 11.62 29 140088 2081 34814733
Oromandibular dystonia 15.19 11.62 14 140103 487 34816327
Infantile apnoea 15.17 11.62 19 140098 942 34815872
Hyperglycaemic hyperosmolar nonketotic syndrome 15.16 11.62 22 140095 1258 34815556
Pharyngeal dystonia 15.16 11.62 7 140110 70 34816744
Seasonal allergy 15.16 11.62 4 140113 6671 34810143
Flat affect 15.13 11.62 18 140099 846 34815968
Pain in jaw 15.08 11.62 18 140099 13022 34803792
Muscle hypertrophy 15.08 11.62 6 140111 40 34816774
Red blood cell sedimentation rate increased 15.07 11.62 9 140108 9153 34807661
Metastases to central nervous system 15.06 11.62 7 140110 8198 34808616
Gastric infection 15.00 11.62 22 140095 1270 34815544
Laryngospasm 14.99 11.62 24 140093 1497 34815317
Diabetes insipidus 14.98 11.62 35 140082 2893 34813921
Blood creatine phosphokinase decreased 14.91 11.62 14 140103 499 34816315
Fear 14.88 11.62 82 140035 10394 34806420
Surgery 14.88 11.62 21 140096 14136 34802678
Loss of employment 14.87 11.62 14 140103 501 34816313
Blood pressure diastolic decreased 14.87 11.62 9 140108 9085 34807729
Sciatica 14.86 11.62 3 140114 6011 34810803
Colon cancer 14.85 11.62 8 140109 8613 34808201
Brachial plexus injury 14.82 11.62 7 140110 74 34816740
Prescribed underdose 14.81 11.62 73 140044 8860 34807954
Epstein-Barr virus infection 14.81 11.62 6 140111 7622 34809192
Device malfunction 14.81 11.62 12 140105 10409 34806405
Oral candidiasis 14.79 11.62 16 140101 12094 34804720
Hyperphagia 14.78 11.62 23 140094 1400 34815414
Troponin I increased 14.76 11.62 33 140084 2649 34814165
Parkinson's disease 14.76 11.62 23 140094 1401 34815413
Growth hormone deficiency 14.75 11.62 11 140106 283 34816531
Oral pain 14.73 11.62 13 140104 10814 34806000
Tongue spasm 14.71 11.62 6 140111 43 34816771
Feminisation acquired 14.71 11.62 6 140111 43 34816771
Small intestinal obstruction 14.70 11.62 23 140094 14843 34801971
Metastases to liver 14.62 11.62 20 140097 13643 34803171
Drug resistance 14.58 11.62 54 140063 25873 34790941
Communication disorder 14.54 11.62 32 140085 2542 34814272
Generalised oedema 14.49 11.62 17 140100 12391 34804423
Condition aggravated 14.48 11.62 924 139193 191272 34625542
Sexual activity increased 14.46 11.62 5 140112 21 34816793
Shoulder deformity 14.45 11.62 4 140113 6 34816808
Maternal exposure during pregnancy 14.43 11.62 48 140069 4870 34811944
Oxygen saturation decreased 14.36 11.62 142 139975 53676 34763138
Injection site swelling 14.33 11.62 15 140102 11512 34805302
Cerebral disorder 14.32 11.62 32 140085 2569 34814245
Yawning 14.26 11.62 14 140103 528 34816286
Dissociative disorder 14.02 11.62 13 140104 456 34816358
Dysphagia 13.95 11.62 338 139779 62043 34754771
Post procedural haemorrhage 13.84 11.62 8 140109 8281 34808533
Nephrotic syndrome 13.77 11.62 6 140111 7297 34809517
Clostridium difficile infection 13.73 11.62 35 140082 18863 34797951
Non-high-density lipoprotein cholesterol increased 13.71 11.62 8 140109 134 34816680
Compulsive shopping 13.65 11.62 12 140105 392 34816422
Movement disorder 13.65 11.62 90 140027 12158 34804656
Brain natriuretic peptide increased 13.62 11.62 3 140114 5656 34811158
Tonic posturing 13.57 11.62 3 140114 0 34816814
Medical device site injury 13.57 11.62 3 140114 0 34816814
Gastroenteritis 13.56 11.62 23 140094 14377 34802437
Congenital pulmonary valve atresia 13.54 11.62 6 140111 54 34816760
Neuroleptic-induced deficit syndrome 13.44 11.62 5 140112 27 34816787
Xanthoma 13.42 11.62 7 140110 93 34816721
Pulmonary toxicity 13.37 11.62 4 140113 6143 34810671
Transfusion 13.34 11.62 9 140108 8576 34808238
Breast inflammation 13.29 11.62 5 140112 28 34816786
Peritonitis bacterial 13.24 11.62 4 140113 6106 34810708
Malignant melanoma 13.23 11.62 8 140109 8082 34808732
Stoma site extravasation 13.23 11.62 7 140110 96 34816718
Hypoxia 13.23 11.62 149 139968 54946 34761868
Mouth ulceration 13.19 11.62 17 140100 11893 34804921
Somatic delusion 13.16 11.62 7 140110 97 34816717
Delusion of reference 13.15 11.62 5 140112 29 34816785
Eye pain 13.15 11.62 21 140096 13441 34803373
Divorced 13.12 11.62 4 140113 10 34816804
Electroencephalogram abnormal 13.10 11.62 30 140087 2448 34814366
Mixed dementia 13.06 11.62 10 140107 268 34816546
Immunodeficiency 13.06 11.62 3 140114 5495 34811319
Sciatic nerve neuropathy 12.99 11.62 6 140111 60 34816754
Urinary tract infection 12.98 11.62 248 139869 83833 34732981
Heart rate abnormal 12.98 11.62 25 140092 1806 34815008
Uveitis 12.97 11.62 7 140110 7528 34809286
Polyneuropathy 12.95 11.62 25 140092 14871 34801943
Intestinal haemorrhage 12.94 11.62 37 140080 3459 34813355
Obsessive-compulsive personality disorder 12.92 11.62 8 140109 150 34816664
Pulmonary alveolar haemorrhage 12.90 11.62 7 140110 7505 34809309
Boredom 12.87 11.62 5 140112 31 34816783
Enterococcal infection 12.87 11.62 11 140106 9295 34807519
Toxic skin eruption 12.87 11.62 16 140101 11369 34805445
Haematocrit decreased 12.85 11.62 76 140041 32140 34784674
End stage renal disease 12.85 11.62 10 140107 8851 34807963
Tendon rupture 12.84 11.62 6 140111 7006 34809808
Endocarditis 12.84 11.62 5 140112 6506 34810308
Intraocular pressure test 12.82 11.62 6 140111 62 34816752
Hepatitis B 12.82 11.62 4 140113 5979 34810835
Conjunctivitis 12.79 11.62 12 140105 9693 34807121
Injection site pruritus 12.75 11.62 6 140111 6977 34809837
Product dose omission issue 12.68 11.62 374 139743 119337 34697477
Hiccups 12.67 11.62 13 140104 10069 34806745
Lung consolidation 12.66 11.62 4 140113 5932 34810882
Vasculitis 12.64 11.62 16 140101 11280 34805534
Chorioretinitis 12.52 11.62 12 140105 439 34816375
Facial spasm 12.46 11.62 9 140108 220 34816594
Skin disorder 12.45 11.62 22 140095 13533 34803281
Tendonitis 12.40 11.62 11 140106 9129 34807685
Hepatomegaly 12.40 11.62 14 140103 10382 34806432
Congenital hydronephrosis 12.39 11.62 15 140102 718 34816096
Gastrooesophageal reflux disease 12.37 11.62 95 140022 37829 34778985
Multiple sclerosis relapse 12.35 11.62 21 140096 13112 34803702
Asocial behaviour 12.34 11.62 6 140111 68 34816746
Mental disability 12.34 11.62 6 140111 68 34816746
Nasal congestion 12.34 11.62 49 140068 23008 34793806
Posterior reversible encephalopathy syndrome 12.32 11.62 13 140104 9941 34806873
Pemphigoid 12.29 11.62 10 140107 8656 34808158
Corneal reflex decreased 12.26 11.62 8 140109 165 34816649
Musculoskeletal chest pain 12.23 11.62 13 140104 9905 34806909
Total cholesterol/HDL ratio increased 12.22 11.62 8 140109 166 34816648
Anal incontinence 12.21 11.62 63 140054 7786 34809028
Haemorrhoids 12.21 11.62 25 140092 14550 34802264
Bacterial sepsis 12.20 11.62 3 140114 5247 34811567
Thrombocytopenic purpura 12.19 11.62 19 140098 1158 34815656
Face oedema 12.18 11.62 17 140100 11499 34805315
Intestinal perforation 12.18 11.62 11 140106 9049 34807765
Floppy infant 12.17 11.62 7 140110 114 34816700
Cardiac arrest 12.14 11.62 486 139631 95673 34721141
Hyponatraemic coma 12.12 11.62 5 140112 37 34816777
Helplessness 12.11 11.62 6 140111 71 34816743
Selective mutism 12.11 11.62 6 140111 71 34816743
Bacterial infection 12.09 11.62 32 140085 17031 34799783
Arachnoid cyst 12.09 11.62 9 140108 231 34816583
Systemic infection 12.07 11.62 3 140114 5209 34811605
Exposure via body fluid 12.07 11.62 7 140110 116 34816698
Liver disorder 12.05 11.62 80 140037 32917 34783897
Pulmonary oedema 12.02 11.62 127 139990 47402 34769412
Benign prostatic hyperplasia 12.02 11.62 25 140092 14470 34802344
Candida infection 11.97 11.62 34 140083 17681 34799133
Cyanosis neonatal 11.96 11.62 10 140107 305 34816509
Proctalgia 11.95 11.62 4 140113 5719 34811095
Agranulocytosis 11.92 11.62 147 139970 23674 34793140
Unevaluable event 11.91 11.62 79 140038 32511 34784303
Disseminated intravascular coagulation 11.90 11.62 46 140071 21770 34795044
Gallbladder polyp 11.84 11.62 11 140106 387 34816427
Metabolic encephalopathy 11.81 11.62 41 140076 4251 34812563
Hyperpyrexia 11.81 11.62 31 140086 2757 34814057
Feeling hot 11.80 11.62 39 140078 19333 34797481
Viral infection 11.78 11.62 34 140083 17589 34799225
Wrong patient received product 11.74 11.62 30 140087 2624 34814190
Rotator cuff syndrome 11.71 11.62 4 140113 5645 34811169
Orthopnoea 11.70 11.62 3 140114 5100 34811714
Blood alkaline phosphatase increased 11.68 11.62 75 140042 31100 34785714

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5234.98 10.67 5667 316214 240100 79182407
Toxicity to various agents 4245.90 10.67 6716 315165 414824 79007683
Sopor 3744.63 10.67 2069 319812 30941 79391566
Suicide attempt 3414.91 10.67 2764 319117 80168 79342339
Intentional overdose 2927.78 10.67 2816 319065 103144 79319363
Neuroleptic malignant syndrome 2817.86 10.67 1614 320267 25945 79396562
Drug abuse 2804.75 10.67 3367 318514 159324 79263183
Overdose 1965.87 10.67 3021 318860 181185 79241322
Drug interaction 1894.58 10.67 4755 317126 410428 79012079
Intentional self-injury 1712.85 10.67 1254 320627 31165 79391342
Sedation 1530.53 10.67 1431 320450 50464 79372043
Somnolence 1474.34 10.67 3086 318795 235895 79186612
Dystonia 1379.52 10.67 935 320946 20464 79402043
Coma 1374.66 10.67 1857 320024 98792 79323715
Dyskinesia 1193.83 10.67 1168 320713 43605 79378902
Electrocardiogram QT prolonged 1178.76 10.67 1631 320250 88755 79333752
Agitation 1151.43 10.67 1698 320183 98017 79324490
Extrapyramidal disorder 1076.81 10.67 823 321058 21856 79400651
Tardive dyskinesia 1063.76 10.67 613 321268 9958 79412549
Depressed level of consciousness 1054.71 10.67 1603 320278 95049 79327458
Suicidal ideation 1039.78 10.67 1407 320474 74933 79347574
Psychotic disorder 889.92 10.67 962 320919 40440 79382067
Akathisia 887.23 10.67 593 321288 12666 79409841
Aggression 860.34 10.67 1045 320836 49913 79372594
Serotonin syndrome 754.61 10.67 920 320961 44107 79378400
Blood prolactin abnormal 743.36 10.67 339 321542 3262 79419245
Mania 715.52 10.67 592 321289 17668 79404839
Muscle rigidity 699.84 10.67 606 321275 19276 79403231
Sexual dysfunction 699.10 10.67 419 321462 7344 79415163
Diarrhoea 687.11 10.67 1595 320286 878894 78543613
Parkinsonism 686.23 10.67 555 321326 16029 79406478
Delusion 677.78 10.67 602 321279 19821 79402686
Dyspnoea 613.32 10.67 1623 320258 855402 78567105
Bradyphrenia 613.06 10.67 434 321447 10206 79412301
Poisoning deliberate 593.24 10.67 539 321342 18289 79404218
Hallucination 586.45 10.67 1157 320724 84588 79337919
Anosognosia 586.44 10.67 292 321589 3472 79419035
Poisoning 577.98 10.67 607 321274 24665 79397842
Schizophrenia 560.46 10.67 479 321402 14961 79407546
Arthralgia 540.24 10.67 925 320956 570878 78851629
Restlessness 539.54 10.67 794 321087 45698 79376809
Paranoia 525.39 10.67 511 321370 18921 79403586
Gestational diabetes 521.34 10.67 322 321559 5971 79416536
Febrile neutropenia 520.39 10.67 144 321737 230855 79191652
Disturbance in social behaviour 518.20 10.67 295 321586 4675 79417832
Hallucination, auditory 511.08 10.67 518 321363 20175 79402332
Delirium 506.79 10.67 1081 320800 83546 79338961
Catatonia 506.43 10.67 358 321523 8398 79414109
Depression 495.84 10.67 1958 319923 214832 79207675
Tachycardia 484.52 10.67 1699 320182 176069 79246438
Abnormal behaviour 463.61 10.67 650 321231 35771 79386736
Psychomotor hyperactivity 461.01 10.67 446 321435 16403 79406104
Altered state of consciousness 445.74 10.67 704 321177 43118 79379389
Confusional state 440.50 10.67 2482 319399 315515 79106992
Metabolic disorder 422.57 10.67 327 321554 8843 79413664
Bradykinesia 410.83 10.67 305 321576 7738 79414769
Pain 400.00 10.67 1478 320403 702324 78720183
Hypomania 398.67 10.67 292 321589 7252 79415255
Priapism 394.91 10.67 239 321642 4266 79418241
Intentional product misuse 385.65 10.67 1045 320836 94120 79328387
Cardio-respiratory arrest 384.48 10.67 1135 320746 107375 79315132
Respiratory arrest 384.30 10.67 769 321112 56781 79365726
Cough 378.37 10.67 559 321322 366230 79056277
Personality change 376.25 10.67 319 321562 9851 79412656
Diabetes mellitus 374.65 10.67 916 320965 77474 79345033
Rash 373.87 10.67 1148 320733 577210 78845297
Blood creatine phosphokinase increased 369.17 10.67 821 321060 65269 79357238
Bezoar 361.98 10.67 189 321692 2499 79420008
Malignant neoplasm progression 360.93 10.67 58 321823 135932 79286575
Disease progression 359.31 10.67 147 321734 184215 79238292
Anaemia 358.09 10.67 791 321090 444224 78978283
Fatigue 350.15 10.67 2260 319621 927467 78495040
Pain in extremity 345.29 10.67 588 321293 363950 79058557
Tremor 340.53 10.67 1475 320406 168608 79253899
Nausea 333.47 10.67 2381 319500 954815 78467692
Pneumonia 327.49 10.67 1462 320419 658784 78763723
Oculogyric crisis 317.97 10.67 179 321702 2773 79419734
Mydriasis 317.66 10.67 374 321507 17269 79405238
Pruritus 311.25 10.67 709 321172 393939 79028568
Hyperprolactinaemia 310.08 10.67 208 321673 4468 79418039
Sinus tachycardia 309.79 10.67 544 321337 36364 79386143
Metabolic syndrome 308.36 10.67 171 321710 2569 79419938
Anxiety 295.87 10.67 1865 320016 246647 79175860
Back pain 290.39 10.67 488 321393 303692 79118815
Prescribed overdose 283.18 10.67 531 321350 37352 79385155
Loss of consciousness 281.07 10.67 1382 320499 166561 79255946
Suspected suicide 274.48 10.67 272 321609 10304 79412203
Sepsis 272.46 10.67 416 321465 269012 79153495
Restless legs syndrome 269.79 10.67 368 321513 19724 79402783
Disorientation 267.04 10.67 702 321179 62074 79360433
Psychiatric decompensation 266.92 10.67 178 321703 3785 79418722
Speech disorder 264.15 10.67 640 321241 53805 79368702
Cardiac failure congestive 262.47 10.67 123 321758 142279 79280228
Rhabdomyolysis 262.25 10.67 964 320917 102167 79320340
Joint swelling 258.40 10.67 482 321399 288164 79134343
Psychomotor skills impaired 255.02 10.67 193 321688 5044 79417463
Obesity 249.77 10.67 482 321399 34643 79387864
Irritability 244.38 10.67 524 321357 40620 79381887
Peripheral swelling 243.29 10.67 448 321433 269169 79153338
Stubbornness 238.77 10.67 81 321800 314 79422193
Seizure 238.38 10.67 1439 320442 187395 79235112
Dysarthria 236.27 10.67 704 321177 66918 79355589
Neuropathy peripheral 235.41 10.67 139 321742 141166 79281341
Atrial fibrillation 229.88 10.67 276 321605 197610 79224897
Galactorrhoea 229.41 10.67 157 321724 3489 79419018
Herpes zoster 229.12 10.67 48 321833 93035 79329472
Headache 225.67 10.67 1629 320252 652143 78770364
Obsessive-compulsive disorder 225.61 10.67 189 321692 5738 79416769
Miosis 225.46 10.67 298 321583 15491 79407016
Type 2 diabetes mellitus 225.08 10.67 621 321260 56501 79366006
Exposure during pregnancy 224.91 10.67 906 320975 100226 79322281
Sinusitis 224.64 10.67 275 321606 195226 79227281
Nasopharyngitis 224.51 10.67 427 321454 253454 79169053
Thinking abnormal 222.17 10.67 270 321611 12891 79409616
Anticholinergic syndrome 221.32 10.67 153 321728 3458 79419049
Psychomotor retardation 220.65 10.67 190 321691 5994 79416513
Hallucination, visual 219.24 10.67 438 321443 32291 79390216
Urinary retention 217.56 10.67 610 321271 56020 79366487
Pyrexia 214.06 10.67 1734 320147 676975 78745532
Drug withdrawal syndrome 210.62 10.67 446 321435 34272 79388235
Blood prolactin increased 206.86 10.67 153 321728 3858 79418649
COVID-19 205.22 10.67 200 321681 157474 79265033
Disturbance in attention 201.86 10.67 554 321327 50247 79372260
Salivary hypersecretion 200.85 10.67 267 321614 13957 79408550
Platelet count decreased 200.17 10.67 297 321584 194367 79228140
Cardiac arrest 199.99 10.67 1284 320597 170812 79251695
Cogwheel rigidity 196.73 10.67 134 321747 2954 79419553
Emotional poverty 194.16 10.67 87 321794 800 79421707
Drug hypersensitivity 193.63 10.67 592 321289 298324 79124183
Haemoglobin decreased 192.51 10.67 378 321503 221741 79200766
Infection 192.17 10.67 432 321449 241280 79181227
Hyperreflexia 190.97 10.67 201 321680 8184 79414323
Bipolar disorder 186.77 10.67 191 321690 7516 79414991
Coma scale abnormal 183.50 10.67 200 321681 8478 79414029
Mucosal inflammation 177.93 10.67 43 321838 75537 79346970
Treatment noncompliance 176.77 10.67 538 321343 51730 79370777
Acute kidney injury 176.71 10.67 1299 320582 518105 78904402
Gastrointestinal haemorrhage 175.85 10.67 202 321679 147517 79274990
Liver injury 174.23 10.67 564 321317 56050 79366457
Interstitial lung disease 168.31 10.67 125 321756 112475 79310032
Antipsychotic drug level increased 167.31 10.67 160 321721 5797 79416710
Malaise 167.15 10.67 1224 320657 488645 78933862
Apathy 165.69 10.67 232 321649 12745 79409762
Hallucinations, mixed 163.61 10.67 169 321712 6730 79415777
Respiratory depression 163.05 10.67 351 321530 27279 79395228
Myocardial infarction 160.70 10.67 312 321569 183817 79238690
Persecutory delusion 159.47 10.67 143 321738 4766 79417741
Schizoaffective disorder 157.95 10.67 102 321779 2050 79420457
Erythema 157.91 10.67 424 321457 222866 79199641
Orthostatic hypertension 157.13 10.67 74 321807 771 79421736
Depressive symptom 155.33 10.67 159 321722 6264 79416243
Anger 154.54 10.67 261 321620 16901 79405606
Substance abuse 153.90 10.67 201 321680 10325 79412182
Hypokinesia 153.57 10.67 276 321605 18784 79403723
Pancytopenia 153.36 10.67 271 321610 165474 79257033
Sleep-related eating disorder 153.01 10.67 69 321812 645 79421862
Chest discomfort 149.42 10.67 203 321678 137841 79284666
Influenza 149.16 10.67 182 321699 129424 79293083
Euphoric mood 147.82 10.67 169 321712 7557 79414950
Derealisation 145.87 10.67 88 321793 1561 79420946
Depression suicidal 145.17 10.67 122 321759 3720 79418787
Withdrawal syndrome 143.64 10.67 328 321553 26526 79395981
Unresponsive to stimuli 143.04 10.67 523 321358 55265 79367242
Myoclonus 142.63 10.67 333 321548 27327 79395180
Hyperthermia 142.54 10.67 259 321622 17778 79404729
Injection site erythema 141.82 10.67 69 321812 78128 79344379
Somnambulism 140.85 10.67 143 321738 5578 79416929
Cellulitis 139.97 10.67 140 321741 108920 79313587
Tearfulness 139.62 10.67 146 321735 5899 79416608
Labour complication 139.17 10.67 41 321840 86 79422421
Urticaria 139.15 10.67 341 321540 184860 79237647
Pleural effusion 138.51 10.67 233 321648 145029 79277478
Posture abnormal 138.38 10.67 119 321762 3747 79418760
Ascites 136.54 10.67 67 321814 75495 79347012
Mental disorder 136.11 10.67 353 321528 30949 79391558
Arthritis 135.74 10.67 158 321723 114722 79307785
Epistaxis 135.43 10.67 150 321731 111365 79311142
Skin ulcer 135.16 10.67 27 321854 54123 79368384
Mental impairment 133.83 10.67 260 321621 18776 79403731
Myelosuppression 133.67 10.67 7 321874 40289 79382218
Pneumonia aspiration 132.51 10.67 579 321302 66388 79356119
Suicidal behaviour 130.79 10.67 107 321774 3140 79419367
Infusion related reaction 130.54 10.67 483 321398 229754 79192753
Urinary tract infection 130.18 10.67 617 321264 273895 79148612
Weight increased 128.86 10.67 1697 320184 275689 79146818
Thrombocytopenia 128.85 10.67 591 321290 264668 79157839
Drug screen positive 128.67 10.67 140 321741 5923 79416584
Diabetic coma 127.05 10.67 73 321808 1178 79421329
Mood altered 126.98 10.67 245 321636 17602 79404905
Cognitive disorder 126.68 10.67 589 321292 69337 79353170
Injection site pain 125.88 10.67 206 321675 129632 79292875
Dyspnoea exertional 125.87 10.67 100 321781 86973 79335534
Pleurothotonus 125.34 10.67 94 321787 2422 79420085
Mood swings 122.44 10.67 257 321624 19623 79402884
Hyperammonaemic encephalopathy 122.26 10.67 122 321759 4660 79417847
Stupor 119.28 10.67 143 321738 6729 79415778
Chills 118.82 10.67 297 321584 159937 79262570
Cytomegalovirus infection 118.16 10.67 16 321865 42628 79379879
Myocarditis 116.85 10.67 266 321615 21467 79401040
Plasma cell myeloma 116.49 10.67 35 321846 53224 79369283
Bipolar I disorder 116.11 10.67 84 321797 2045 79420462
Depersonalisation/derealisation disorder 114.37 10.67 79 321802 1783 79420724
Medication error 114.08 10.67 564 321317 68078 79354429
Productive cough 113.79 10.67 113 321768 88218 79334289
Thrombosis 113.71 10.67 103 321778 83997 79338510
Depressed mood 113.11 10.67 441 321440 48039 79374468
Hypersensitivity 111.51 10.67 612 321269 261627 79160880
Asthenia 111.40 10.67 1427 320454 510262 78912245
Psychotic symptom 111.00 10.67 90 321791 2607 79419900
Drooling 110.49 10.67 128 321753 5806 79416701
Drug dependence 109.44 10.67 388 321493 40381 79382126
Dissociation 109.16 10.67 106 321775 3915 79418592
Logorrhoea 109.10 10.67 110 321771 4255 79418252
Stomatitis 108.05 10.67 273 321608 146484 79276023
Flushing 107.98 10.67 118 321763 88150 79334357
Neoplasm progression 107.66 10.67 37 321844 51645 79370862
Abdominal pain 107.14 10.67 1030 320851 388539 79033968
Hyperkalaemia 106.75 10.67 186 321695 114212 79308295
Colitis 106.19 10.67 84 321797 73223 79349284
Blood pressure increased 106.17 10.67 465 321416 210895 79211612
Basal cell carcinoma 106.02 10.67 13 321868 37362 79385145
Anaphylactic reaction 104.61 10.67 110 321771 83633 79338874
Electrocardiogram QRS complex prolonged 103.23 10.67 169 321712 10664 79411843
Clonus 102.16 10.67 132 321749 6708 79415799
Osteonecrosis of jaw 100.94 10.67 25 321856 43201 79379306
Pneumocystis jirovecii pneumonia 100.86 10.67 8 321873 32500 79390007
Colitis ischaemic 99.81 10.67 203 321678 15156 79407351
Accidental death 99.75 10.67 104 321777 4187 79418320
Nasal congestion 98.53 10.67 98 321783 76454 79346053
Bronchitis 97.75 10.67 241 321640 130403 79292104
Coronary artery disease 97.42 10.67 73 321808 65401 79357106
Homicidal ideation 97.37 10.67 93 321788 3364 79419143
Hypothermia 97.34 10.67 255 321626 22491 79400016
Diverticulitis 97.23 10.67 32 321849 45904 79376603
Impulse-control disorder 96.76 10.67 70 321811 1704 79420803
Social avoidant behaviour 96.69 10.67 108 321773 4706 79417801
Weight decreased 94.34 10.67 947 320934 354251 79068256
Feeling of despair 93.27 10.67 83 321798 2738 79419769
Behaviour disorder 92.99 10.67 121 321760 6192 79416315
Faecaloma 92.58 10.67 167 321714 11397 79411110
Aspiration 92.49 10.67 232 321649 19926 79402581
Rash pruritic 91.84 10.67 92 321789 71537 79350970
Prescribed underdose 91.67 10.67 295 321586 29219 79393288
Hyperkinesia 91.63 10.67 81 321800 2648 79419859
Myoglobin urine present 90.18 10.67 53 321828 894 79421613
Disorganised speech 90.01 10.67 72 321809 2045 79420462
Bone marrow failure 89.81 10.67 47 321834 51060 79371447
Bone pain 89.78 10.67 57 321824 55685 79366822
Rhinorrhoea 89.45 10.67 105 321776 75969 79346538
Disinhibition 89.01 10.67 78 321803 2520 79419987
Embolism venous 88.42 10.67 97 321784 4142 79418365
Septic shock 88.42 10.67 231 321650 122570 79299937
Renal failure 88.18 10.67 464 321417 200504 79222003
Palmar-plantar erythrodysaesthesia syndrome 88.17 10.67 14 321867 33120 79389387
Chest pain 86.94 10.67 725 321156 281579 79140928
Major depression 86.80 10.67 141 321740 8839 79413668
Dry skin 86.41 10.67 88 321793 67907 79354600
Cytokine release syndrome 85.67 10.67 20 321861 35978 79386529
Akinesia 85.61 10.67 85 321796 3227 79419280
Abdominal discomfort 85.56 10.67 626 321255 250101 79172406
Accidental overdose 85.09 10.67 351 321530 39230 79383277
Swelling 85.01 10.67 519 321362 216192 79206315
Renal impairment 84.88 10.67 338 321543 157445 79265062
Cardiac failure 84.38 10.67 330 321551 154512 79267995
Nightmare 83.53 10.67 262 321619 25599 79396908
Injection site pruritus 83.47 10.67 33 321848 42250 79380257
On and off phenomenon 83.46 10.67 83 321798 3157 79419350
Injection site swelling 83.33 10.67 43 321838 47089 79375418
Dementia 82.59 10.67 253 321628 24406 79398101
Oropharyngeal pain 82.37 10.67 201 321680 109152 79313355
Acute myeloid leukaemia 82.30 10.67 13 321868 30872 79391635
Exposure via ingestion 82.26 10.67 103 321778 5071 79417436
Generalised tonic-clonic seizure 81.84 10.67 373 321508 43537 79378970
Psychiatric symptom 81.36 10.67 120 321761 6915 79415592
Gastrointestinal disorder 81.19 10.67 239 321642 121966 79300541
Drug intolerance 80.55 10.67 680 321201 263439 79159068
Pneumonitis 80.54 10.67 76 321805 60784 79361723
Sleep disorder 80.43 10.67 607 321274 85070 79337437
Gastric pH decreased 80.23 10.67 48 321833 838 79421669
Decreased appetite 79.68 10.67 941 320940 341477 79081030
Hypotension 78.95 10.67 2331 319550 437986 78984521
Affect lability 78.19 10.67 153 321728 11106 79411401
Full blood count abnormal 77.61 10.67 33 321848 40441 79382066
Amenorrhoea 77.39 10.67 123 321758 7569 79414938
Nephrolithiasis 77.27 10.67 61 321820 53230 79369277
Rheumatoid arthritis 76.26 10.67 510 321371 207960 79214547
Neutropenic sepsis 75.35 10.67 10 321871 27054 79395453
Antipsychotic drug level below therapeutic 74.81 10.67 52 321829 1186 79421321
Antipsychotic drug level above therapeutic 74.40 10.67 64 321817 2016 79420491
Blood triglycerides increased 74.36 10.67 220 321661 20820 79401687
Slow speech 74.27 10.67 69 321812 2409 79420098
Tic 74.17 10.67 75 321806 2911 79419596
Tension 73.76 10.67 90 321791 4314 79418193
Oedema peripheral 73.18 10.67 658 321223 251630 79170877
Torsade de pointes 73.14 10.67 207 321674 19105 79403402
Synovitis 73.04 10.67 336 321545 150398 79272109
Cerebrovascular accident 72.99 10.67 350 321531 154942 79267565
Insomnia 72.80 10.67 1392 320489 243778 79178729
Torticollis 72.57 10.67 67 321814 2320 79420187
Electrocardiogram QRS complex shortened 72.54 10.67 42 321839 688 79421819
Stereotypy 72.35 10.67 46 321835 899 79421608
Impulsive behaviour 72.33 10.67 73 321808 2827 79419680
Visceral congestion 71.86 10.67 46 321835 910 79421597
Alcohol abuse 71.65 10.67 98 321783 5265 79417242
Abulia 71.56 10.67 47 321834 973 79421534
Localised infection 71.47 10.67 31 321850 37544 79384963
Blood cholesterol increased 70.79 10.67 579 321302 83141 79339366
Panic attack 70.69 10.67 237 321644 23979 79398528
Granulocytopenia 70.65 10.67 148 321733 11283 79411224
Myalgia 69.49 10.67 451 321430 185190 79237317
Enuresis 68.55 10.67 74 321807 3102 79419405
Hypervolaemia 68.27 10.67 44 321837 42646 79379861
Myelodysplastic syndrome 67.94 10.67 19 321862 30282 79392225
Bronchopulmonary aspergillosis 67.75 10.67 6 321875 22288 79400219
Bruxism 66.98 10.67 82 321799 3944 79418563
Rectal haemorrhage 66.77 10.67 129 321752 76171 79346336
Drug level increased 66.02 10.67 326 321555 39325 79383182
Dehydration 65.72 10.67 662 321219 247525 79174982
Mutism 65.27 10.67 63 321818 2309 79420198
Oromandibular dystonia 65.25 10.67 45 321836 1013 79421494
Memory impairment 64.67 10.67 713 321168 111021 79311486
Aspergillus infection 64.60 10.67 3 321878 19158 79403349
Alopecia 63.81 10.67 611 321270 230744 79191763
Coma blister 63.71 10.67 27 321854 214 79422293
Stoma site discharge 63.31 10.67 60 321821 2149 79420358
Acute psychosis 62.95 10.67 81 321800 4099 79418408
Prostate cancer 62.40 10.67 28 321853 33240 79389267
Tumour lysis syndrome 61.74 10.67 11 321870 23928 79398579
Acute myocardial infarction 61.70 10.67 137 321744 76899 79345608
Fungal infection 61.52 10.67 47 321834 41701 79380806
Red blood cell sedimentation rate increased 61.22 10.67 57 321824 45885 79376622
Haemophagocytic lymphohistiocytosis 60.96 10.67 8 321873 21829 79400678
Clostridium difficile colitis 60.82 10.67 27 321854 32256 79390251
Hypocalcaemia 60.76 10.67 67 321814 49857 79372650
Pain in jaw 60.63 10.67 58 321823 46093 79376414
Malignant catatonia 60.63 10.67 32 321849 433 79422074
Tachyphrenia 60.57 10.67 57 321824 2023 79420484
Amnesia 60.45 10.67 449 321432 62608 79359899
Osteonecrosis 60.19 10.67 25 321856 31070 79391437
Full blood count decreased 59.79 10.67 17 321864 26802 79395705
Transplant rejection 59.70 10.67 5 321876 19432 79403075
Haematuria 59.70 10.67 117 321764 68719 79353788
Dysphoria 59.49 10.67 84 321797 4650 79417857
Schizophreniform disorder 59.00 10.67 23 321858 143 79422364
Vomiting 58.88 10.67 2147 319734 663681 78758826
Swollen joint count increased 58.80 10.67 215 321666 22712 79399795
Hypertonia 58.61 10.67 105 321776 7127 79415380
Long QT syndrome 58.23 10.67 94 321787 5861 79416646
Osteomyelitis 58.08 10.67 30 321851 32835 79389672
Neck pain 58.08 10.67 137 321744 75280 79347227
Lower respiratory tract infection 57.98 10.67 296 321585 128924 79293583
Arthropathy 57.64 10.67 448 321433 176663 79245844
Alcohol interaction 57.61 10.67 84 321797 4790 79417717
Self-injurious ideation 57.16 10.67 72 321809 3566 79418941
Blood pressure systolic increased 57.11 10.67 115 321766 66871 79355636
Angioedema 57.07 10.67 140 321741 75895 79346612
Pulmonary hypertension 56.91 10.67 66 321815 48014 79374493
Alcohol poisoning 56.86 10.67 83 321798 4738 79417769
Hyperammonaemia 56.58 10.67 133 321748 10960 79411547
Oropharyngeal spasm 56.58 10.67 30 321851 410 79422097
Breast cancer 56.55 10.67 33 321848 33748 79388759
Bacteraemia 56.48 10.67 31 321850 32793 79389714
Musculoskeletal pain 56.48 10.67 217 321664 102137 79320370
Tubulointerstitial nephritis 56.40 10.67 43 321838 38192 79384315
Hypersomnia 56.30 10.67 213 321668 22873 79399634
Upper respiratory tract infection 55.82 10.67 185 321696 90983 79331524
Product dose omission issue 55.73 10.67 685 321196 246852 79175655
Dysphonia 55.32 10.67 90 321791 56782 79365725
Distributive shock 55.20 10.67 61 321820 2626 79419881
Epilepsy 55.09 10.67 317 321564 40543 79381964
Haemorrhage 55.03 10.67 186 321695 90932 79331575
Anaphylactic shock 55.02 10.67 39 321842 35957 79386550
Polydipsia 54.95 10.67 97 321784 6508 79415999
Leukopenia 54.92 10.67 715 321166 115798 79306709
Device expulsion 54.76 10.67 18 321863 25843 79396664
Attention deficit hyperactivity disorder 54.41 10.67 67 321814 3242 79419265
Abnormal weight gain 54.28 10.67 60 321821 2584 79419923
Negativism 53.91 10.67 37 321844 826 79421681
Menstrual disorder 53.85 10.67 74 321807 3993 79418514
Product substitution issue 53.69 10.67 192 321689 20064 79402443
Metastases to bone 53.51 10.67 16 321865 24411 79398096
Hypercalcaemia 53.22 10.67 46 321835 38384 79384123
Troponin increased 53.18 10.67 185 321696 19070 79403437
Pseudomonas infection 53.06 10.67 10 321871 20893 79401614
Pulmonary arterial hypertension 53.01 10.67 24 321857 28342 79394165
Refusal of examination 52.94 10.67 23 321858 195 79422312
Stoma site erythema 52.90 10.67 49 321832 1704 79420803
Somatic symptom disorder 52.82 10.67 58 321823 2479 79420028
Circulatory collapse 52.60 10.67 295 321586 37373 79385134
Brugada syndrome 52.41 10.67 42 321839 1196 79421311
Inappropriate affect 52.39 10.67 46 321835 1490 79421017
Emotional disorder 52.34 10.67 152 321729 14235 79408272
Urinary incontinence 52.32 10.67 313 321568 40596 79381911
Metastases to lung 52.30 10.67 6 321875 18157 79404350
Incontinence 51.87 10.67 150 321731 14014 79408493
Incoherent 51.57 10.67 103 321778 7589 79414918
Psychotic behaviour 51.45 10.67 40 321841 1089 79421418
Muscle twitching 51.19 10.67 217 321664 24547 79397960
Injection site bruising 51.04 10.67 54 321827 40948 79381559
Viral infection 50.97 10.67 59 321822 42957 79379550
Increased appetite 50.96 10.67 134 321747 11844 79410663
Hypersexuality 50.78 10.67 47 321834 1633 79420874
Postural tremor 50.77 10.67 34 321847 728 79421779
Poverty of speech 50.74 10.67 31 321850 563 79421944
Judgement impaired 50.61 10.67 42 321839 1258 79421249
Sexually inappropriate behaviour 50.59 10.67 30 321851 515 79421992
Trismus 50.36 10.67 84 321797 5383 79417124
Injection site reaction 50.26 10.67 90 321791 54695 79367812
Proteinuria 49.96 10.67 35 321846 32467 79390040
Ataxia 49.90 10.67 217 321664 24822 79397685
Dyspepsia 49.88 10.67 247 321634 108440 79314067
Therapeutic product effect decreased 49.87 10.67 422 321459 163441 79259066
Dysgeusia 49.74 10.67 97 321784 57080 79365427
Fluid retention 49.72 10.67 132 321749 69677 79352830
Homicide 49.71 10.67 40 321841 1146 79421361
Jealous delusion 49.64 10.67 25 321856 305 79422202
Freezing phenomenon 49.25 10.67 49 321832 1865 79420642
Multiple organ dysfunction syndrome 49.22 10.67 284 321597 119962 79302545
Status epilepticus 49.13 10.67 216 321665 24825 79397682
Hypotonia 48.79 10.67 138 321743 12732 79409775
Reduced facial expression 48.75 10.67 58 321823 2707 79419800
Rheumatic fever 48.54 10.67 236 321645 28289 79394218
Parkinsonian gait 48.52 10.67 36 321845 912 79421595
Infarction 48.50 10.67 75 321806 4507 79418000
Angina pectoris 48.34 10.67 84 321797 51648 79370859
Hypoacusis 48.32 10.67 31 321850 30119 79392388
Urinary hesitation 48.23 10.67 72 321809 4194 79418313
Anticonvulsant drug level above therapeutic 48.03 10.67 39 321842 1132 79421375
Progressive multifocal leukoencephalopathy 47.93 10.67 12 321869 20588 79401919
Oral pain 47.88 10.67 35 321846 31763 79390744
Hot flush 47.82 10.67 93 321788 54784 79367723
Tenosynovitis 47.77 10.67 4 321877 15550 79406957
Gout 47.74 10.67 20 321861 24729 79397778
Psoriasis 47.47 10.67 193 321688 89394 79333113
Sinus congestion 47.45 10.67 11 321870 19885 79402622
Chronic kidney disease 47.18 10.67 125 321756 66029 79356478
Haematochezia 46.96 10.67 188 321693 87457 79335050
Gastric disorder 46.93 10.67 49 321832 37384 79385123
Feeling guilty 46.77 10.67 34 321847 834 79421673
Hypertriglyceridaemia 46.73 10.67 135 321746 12605 79409902
Adverse drug reaction 46.70 10.67 441 321440 65951 79356556
Compartment syndrome 46.70 10.67 78 321803 5004 79417503
Neoplasm malignant 46.63 10.67 36 321845 31774 79390733
Throat irritation 46.56 10.67 58 321823 40888 79381619
Food interaction 46.45 10.67 45 321836 1657 79420850
Language disorder 46.41 10.67 61 321820 3153 79419354
Haemoptysis 46.16 10.67 98 321783 55901 79366606
Bundle branch block right 45.98 10.67 124 321757 11127 79411380
Suspiciousness 45.85 10.67 30 321851 617 79421890
Hypomagnesaemia 45.85 10.67 74 321807 46837 79375670
Tooth infection 45.74 10.67 10 321871 18822 79403685
Slow response to stimuli 45.63 10.67 46 321835 1779 79420728
Electrocardiogram abnormal 45.52 10.67 160 321721 16577 79405930
Nodule 45.30 10.67 18 321863 22976 79399531
Alcoholism 45.22 10.67 65 321816 3658 79418849
Oppositional defiant disorder 45.20 10.67 27 321854 470 79422037
Device related infection 45.17 10.67 43 321838 34251 79388256
Haematotoxicity 45.01 10.67 5 321876 15514 79406993
Self esteem decreased 44.58 10.67 35 321846 967 79421540
Rabbit syndrome 44.57 10.67 24 321857 339 79422168
Electrocardiogram QT interval abnormal 44.52 10.67 23 321858 297 79422210
Antipsychotic drug level decreased 44.47 10.67 38 321843 1186 79421321
Surgery 44.44 10.67 40 321841 32726 79389781
White blood cell count decreased 44.29 10.67 516 321365 187772 79234735
Respiratory tract infection 43.75 10.67 81 321800 48608 79373899
Right ventricular failure 43.72 10.67 20 321861 23477 79399030
Inflammation 43.63 10.67 212 321669 93541 79328966
Insurance issue 43.63 10.67 81 321800 5652 79416855
Sinus disorder 43.58 10.67 18 321863 22446 79400061
Lymphadenopathy 43.21 10.67 94 321787 53153 79369354
Rash maculo-papular 43.07 10.67 102 321779 55976 79366531
Bradypnoea 42.95 10.67 83 321798 5969 79416538
Toxic epidermal necrolysis 42.94 10.67 71 321810 44510 79377997
Pneumothorax 42.88 10.67 31 321850 28292 79394215
Metastases to liver 42.85 10.67 31 321850 28283 79394224
Therapy interrupted 42.82 10.67 38 321843 31303 79391204
Jaundice cholestatic 42.78 10.67 121 321760 11163 79411344
Anaemia of pregnancy 42.72 10.67 15 321866 66 79422441
Blood creatinine increased 42.52 10.67 410 321471 154647 79267860
Bladder cancer 42.39 10.67 13 321868 19513 79402994
Pulmonary mass 42.38 10.67 33 321848 29001 79393506
Apraxia 42.30 10.67 55 321826 2812 79419695
Antidepressant drug level above therapeutic 42.27 10.67 29 321852 647 79421860
Adrenal insufficiency 42.07 10.67 32 321849 28455 79394052
Mouth ulceration 41.99 10.67 56 321825 38338 79384169
Illusion 41.92 10.67 43 321838 1698 79420809
Hyperhidrosis 41.85 10.67 851 321030 150641 79271866
Conversion disorder 41.29 10.67 44 321837 1817 79420690
Gastrooesophageal reflux disease 41.19 10.67 249 321632 103997 79318510
Tenderness 41.16 10.67 22 321859 23620 79398887
Skin exfoliation 40.92 10.67 102 321779 54998 79367509
Drug ineffective 40.91 10.67 3783 318098 1077130 78345377
Pyramidal tract syndrome 40.65 10.67 27 321854 570 79421937
Pathogen resistance 40.65 10.67 5 321876 14337 79408170
Mental status changes 40.45 10.67 431 321450 66528 79355979
Chronic obstructive pulmonary disease 40.42 10.67 192 321689 85227 79337280
Muscular weakness 40.36 10.67 434 321447 160295 79262212
International normalised ratio increased 40.34 10.67 190 321691 84531 79337976
Brain injury 40.29 10.67 120 321761 11397 79411110
Flight of ideas 40.28 10.67 31 321850 831 79421676
Feelings of worthlessness 40.11 10.67 26 321855 526 79421981
Stoma site hypergranulation 40.01 10.67 24 321857 421 79422086
Transfusion 39.93 10.67 18 321863 21312 79401195
Drug diversion 39.79 10.67 36 321845 1214 79421293
Lymphocyte count decreased 39.61 10.67 82 321799 47207 79375300
Binge eating 39.53 10.67 25 321856 484 79422023
Blood glucose increased 39.45 10.67 668 321213 114307 79308200
Psychosexual disorder 39.32 10.67 16 321865 113 79422394
Hyperphagia 39.29 10.67 50 321831 2502 79420005
Resting tremor 39.25 10.67 39 321842 1482 79421025
Pyromania 39.09 10.67 11 321870 18 79422489
Eye pruritus 39.07 10.67 17 321864 20553 79401954
Sympathomimetic effect 39.06 10.67 15 321866 89 79422418
Ulcer 38.99 10.67 38 321843 29934 79392573
Faeces discoloured 38.97 10.67 36 321845 29091 79393416
Tendonitis 38.88 10.67 24 321857 23806 79398701
Cystitis 38.86 10.67 98 321783 52634 79369873
Heart rate decreased 38.84 10.67 149 321732 70167 79352340
Sudden cardiac death 38.74 10.67 73 321808 5152 79417355
Paradoxical drug reaction 38.69 10.67 88 321793 7097 79415410
Squamous cell carcinoma 38.55 10.67 8 321873 15614 79406893
Deep vein thrombosis postoperative 38.54 10.67 113 321768 10639 79411868
Affective disorder 38.43 10.67 96 321785 8223 79414284
Personality change due to a general medical condition 38.37 10.67 19 321862 223 79422284
Accidental poisoning 38.23 10.67 40 321841 1617 79420890
Dependence 38.16 10.67 48 321833 2374 79420133
Sleep disorder due to a general medical condition 38.06 10.67 6 321875 14271 79408236
Labelled drug-drug interaction issue 37.89 10.67 37 321844 1376 79421131
Coagulopathy 37.89 10.67 54 321827 35952 79386555
Pulmonary toxicity 37.86 10.67 4 321877 12910 79409597
Diet refusal 37.84 10.67 30 321851 841 79421666
Gastroenteritis viral 37.82 10.67 27 321854 24804 79397703
Anxiolytic therapy 37.81 10.67 13 321868 53 79422454
Drug therapy enhancement 37.81 10.67 13 321868 53 79422454
Dyslipidaemia 37.70 10.67 118 321763 11515 79410992
Burning mouth syndrome 37.63 10.67 25 321856 528 79421979
Blunted affect 37.57 10.67 24 321857 473 79422034
Tongue spasm 37.47 10.67 15 321866 101 79422406
Immunosuppression 37.45 10.67 4 321877 12799 79409708
Excessive eye blinking 37.36 10.67 40 321841 1661 79420846
Squamous cell carcinoma of skin 37.18 10.67 6 321875 14027 79408480
Injection site rash 37.14 10.67 13 321868 17941 79404566
Dystonic tremor 37.13 10.67 18 321863 201 79422306
COVID-19 pneumonia 37.04 10.67 37 321844 28812 79393695
Gastroenteritis 36.98 10.67 50 321831 34032 79388475
Enteritis 36.96 10.67 7 321874 14576 79407931
Acute generalised exanthematous pustulosis 36.55 10.67 12 321869 17242 79405265
Feeling of body temperature change 36.53 10.67 72 321809 5254 79417253
Eosinophil count decreased 36.53 10.67 56 321825 3340 79419167
Pressure of speech 36.43 10.67 34 321847 1194 79421313
Skin lesion 36.38 10.67 71 321810 41773 79380734
Floppy iris syndrome 36.38 10.67 21 321860 342 79422165
Nephrogenic diabetes insipidus 36.37 10.67 44 321837 2090 79420417
Oxygen saturation decreased 36.33 10.67 339 321542 128708 79293799
Amniotic fluid volume increased 36.20 10.67 16 321865 142 79422365
Neuralgia 36.19 10.67 49 321832 33335 79389172
Bone disorder 35.98 10.67 16 321865 19097 79403410
Sluggishness 35.95 10.67 81 321800 6491 79416016
Decreased eye contact 35.89 10.67 29 321852 836 79421671
Burning sensation 35.87 10.67 119 321762 58513 79363994
Loss of libido 35.77 10.67 49 321832 2636 79419871
Screaming 35.65 10.67 60 321821 3873 79418634
Haemorrhoids 35.55 10.67 39 321842 29089 79393418
Malignant melanoma 35.45 10.67 8 321873 14733 79407774
Hypophosphataemia 35.45 10.67 18 321863 19895 79402612
Schizoaffective disorder bipolar type 35.43 10.67 18 321863 224 79422283
Manic symptom 35.38 10.67 15 321866 119 79422388
Blood calcium decreased 35.21 10.67 46 321835 31773 79390734
H1N1 influenza 35.12 10.67 47 321834 2472 79420035
Facet joint syndrome 35.12 10.67 113 321768 11189 79411318
Lip swelling 35.07 10.67 70 321811 40841 79381666
Flatulence 35.02 10.67 75 321806 42649 79379858
Arrhythmia 34.98 10.67 390 321491 60882 79361625
Tongue biting 34.96 10.67 43 321838 2078 79420429
Melaena 34.95 10.67 127 321754 60763 79361744
Gambling disorder 34.90 10.67 42 321839 1984 79420523
Action tremor 34.78 10.67 22 321859 426 79422081
Colon cancer 34.69 10.67 8 321873 14515 79407992
Sudden death 34.61 10.67 181 321700 22330 79400177
Macular degeneration 34.44 10.67 3 321878 11293 79411214
Immune reconstitution inflammatory syndrome 34.33 10.67 7 321874 13834 79408673
Carpal tunnel syndrome 34.25 10.67 18 321863 19510 79402997
Myoclonic epilepsy 34.20 10.67 41 321840 1929 79420578
Multiple drug therapy 34.07 10.67 60 321821 4018 79418489
Colitis ulcerative 33.77 10.67 55 321826 34687 79387820
Libido increased 33.69 10.67 41 321840 1960 79420547
Oesophageal carcinoma 33.64 10.67 3 321878 11081 79411426
Metastases to central nervous system 33.63 10.67 12 321869 16363 79406144
Upper gastrointestinal haemorrhage 33.62 10.67 73 321808 41307 79381200
Wrong patient received product 33.59 10.67 64 321817 4554 79417953
Uveitis 33.44 10.67 13 321868 16817 79405690
Clostridium difficile infection 33.29 10.67 77 321804 42608 79379899
Hypogammaglobulinaemia 33.29 10.67 6 321875 12945 79409562
Osmolar gap increased 33.25 10.67 14 321867 109 79422398
Gastritis 33.23 10.67 92 321789 47901 79374606
Eczema 33.17 10.67 72 321809 40746 79381761
Adjustment disorder with depressed mood 33.06 10.67 96 321785 8990 79413517
Decreased interest 32.98 10.67 56 321825 3641 79418866
Potentiating drug interaction 32.88 10.67 94 321787 8725 79413782
Injection site urticaria 32.84 10.67 6 321875 12820 79409687
Disseminated intravascular coagulation 32.77 10.67 59 321822 35783 79386724
Gynaecomastia 32.75 10.67 86 321795 7595 79414912
Procedural pain 32.74 10.67 27 321854 23057 79399450
Gastric ulcer 32.65 10.67 54 321827 33851 79388656
Blood urine present 32.65 10.67 23 321858 21274 79401233
Bone density decreased 32.59 10.67 7 321874 13340 79409167
Crying 32.53 10.67 181 321700 22862 79399645
Congestive cardiomyopathy 32.37 10.67 113 321768 11667 79410840
Self-medication 32.37 10.67 67 321814 5065 79417442
Delusional disorder, persecutory type 32.26 10.67 22 321859 486 79422021
Candida infection 32.23 10.67 66 321815 38148 79384359
Type 1 diabetes mellitus 32.12 10.67 80 321801 6839 79415668
Delusional disorder, unspecified type 31.98 10.67 26 321855 756 79421751
Therapeutic product effect variable 31.95 10.67 40 321841 1969 79420538
Injection site warmth 31.89 10.67 10 321871 14797 79407710
Staphylococcal infection 31.89 10.67 124 321757 58171 79364336
Urine osmolarity increased 31.85 10.67 18 321863 281 79422226
Intervertebral disc protrusion 31.84 10.67 29 321852 23592 79398915
Blood pressure fluctuation 31.72 10.67 151 321730 66994 79355513
Inappropriate antidiuretic hormone secretion 31.55 10.67 198 321683 26115 79396392
Ejection fraction decreased 31.53 10.67 57 321824 34520 79387987
Diabetes insipidus 31.43 10.67 67 321814 5170 79417337
Penis injury 31.41 10.67 14 321867 127 79422380
Cytopenia 31.26 10.67 22 321859 20361 79402146
Panniculitis 31.22 10.67 6 321875 12365 79410142
Abdominal pain upper 31.18 10.67 677 321204 223142 79199365
Appendicitis 31.17 10.67 23 321858 20771 79401736
Tooth disorder 31.06 10.67 36 321845 26197 79396310
Skin reaction 30.97 10.67 13 321868 16055 79406452
Generalised oedema 30.91 10.67 30 321851 23679 79398828
Acute coronary syndrome 30.87 10.67 24 321857 21109 79401398
Refusal of treatment by patient 30.81 10.67 93 321788 8898 79413609
Lymphoma 30.76 10.67 16 321865 17444 79405063
Hyporesponsive to stimuli 30.72 10.67 40 321841 2048 79420459
Product tampering 30.71 10.67 20 321861 408 79422099
Polyarthritis 30.62 10.67 6 321875 12196 79410311
Oral candidiasis 30.62 10.67 45 321836 29583 79392924
Cholangitis 30.59 10.67 7 321874 12769 79409738
Acute respiratory failure 30.47 10.67 130 321751 59411 79363096
Diffuse large B-cell lymphoma 30.44 10.67 6 321875 12143 79410364
Pancreatitis 30.31 10.67 416 321465 68159 79354348
Peripheral venous disease 30.28 10.67 136 321745 15773 79406734
Breast cancer female 30.14 10.67 5 321876 11456 79411051
Post procedural complication 30.09 10.67 31 321850 23798 79398709
Autonomic nervous system imbalance 29.85 10.67 61 321820 4569 79417938
Skin necrosis 29.81 10.67 18 321863 18069 79404438
Nuchal rigidity 29.77 10.67 29 321852 1075 79421432
Herbal interaction 29.76 10.67 21 321860 491 79422016
Blepharospasm 29.68 10.67 70 321811 5781 79416726
Ageusia 29.66 10.67 15 321866 16617 79405890
Otospondylomegaepiphyseal dysplasia 29.43 10.67 10 321871 39 79422468
Adjustment disorder with mixed anxiety and depressed mood 29.35 10.67 13 321868 116 79422391
Necrotising colitis 29.33 10.67 28 321853 1012 79421495
Impaired healing 29.31 10.67 220 321661 87435 79335072
Withdrawal catatonia 29.29 10.67 15 321866 190 79422317
Withdrawal arrhythmia 29.23 10.67 10 321871 40 79422467
Hypertension 29.22 10.67 1067 320814 329925 79092582
Vasculitis 29.13 10.67 35 321846 25067 79397440
Live birth 29.02 10.67 151 321730 18593 79403914
Hypoalbuminaemia 28.88 10.67 26 321855 21271 79401236
Diverticulum 28.79 10.67 12 321869 14884 79407623
Physical assault 28.75 10.67 34 321847 1577 79420930
Renal cancer 28.68 10.67 7 321874 12219 79410288
Second primary malignancy 28.65 10.67 11 321870 14339 79408168
Atrial flutter 28.61 10.67 27 321854 21598 79400909
Job dissatisfaction 28.54 10.67 11 321870 66 79422441
Prostatic specific antigen increased 28.53 10.67 4 321877 10382 79412125
Merycism 28.41 10.67 16 321865 248 79422259
Post procedural haemorrhage 28.35 10.67 10 321871 13734 79408773
Grimacing 28.31 10.67 23 321858 668 79421839
Organising pneumonia 28.27 10.67 5 321876 10934 79411573
Pulmonary haemorrhage 28.21 10.67 12 321869 14705 79407802
Dementia with Lewy bodies 28.18 10.67 25 321856 821 79421686
Tuberculosis 28.18 10.67 13 321868 15185 79407322
Stoma site inflammation 28.17 10.67 23 321858 673 79421834
Electrocardiogram repolarisation abnormality 28.16 10.67 40 321841 2227 79420280
Rebound psychosis 28.12 10.67 18 321863 356 79422151
Lip dry 28.00 10.67 130 321751 15288 79407219
Influenza like illness 27.94 10.67 172 321709 71535 79350972
Cholecystitis 27.93 10.67 29 321852 22183 79400324
Protein C increased 27.90 10.67 12 321869 99 79422408
Cushingoid 27.90 10.67 3 321878 9549 79412958
Angina unstable 27.87 10.67 16 321865 16511 79405996
Delusional perception 27.86 10.67 18 321863 362 79422145
Diabetic ketoacidosis 27.77 10.67 234 321647 33888 79388619
Social anxiety disorder 27.71 10.67 21 321860 550 79421957
Convulsive threshold lowered 27.67 10.67 26 321855 921 79421586
Staring 27.58 10.67 43 321838 2602 79419905
Peripartum cardiomyopathy 27.56 10.67 13 321868 136 79422371
Parkinsonian rest tremor 27.48 10.67 16 321865 265 79422242
Skin disorder 27.48 10.67 60 321821 33883 79388624
Toxic encephalopathy 27.44 10.67 105 321776 11335 79411172
Negative thoughts 27.44 10.67 31 321850 1368 79421139
Obsessive thoughts 27.33 10.67 28 321853 1104 79421403
Hangover 27.32 10.67 38 321843 2074 79420433
Morbid thoughts 27.32 10.67 24 321857 778 79421729
Neutrophil count decreased 27.23 10.67 245 321636 93714 79328793
Creatinine renal clearance decreased 27.23 10.67 22 321859 18980 79403527
Device difficult to use 27.16 10.67 10 321871 13375 79409132
Trichoglossia 27.14 10.67 22 321859 637 79421870
Swelling face 27.14 10.67 172 321709 71040 79351467
Microphthalmos 27.10 10.67 6 321875 0 79422507
Atrioventricular block first degree 27.02 10.67 111 321770 12380 79410127
Product storage error 26.95 10.67 16 321865 16210 79406297
Hepatic cancer 26.80 10.67 5 321876 10524 79411983
Therapeutic product effect incomplete 26.80 10.67 406 321475 141239 79281268
Aspartate aminotransferase increased 26.71 10.67 396 321485 138245 79284262
Oesophageal candidiasis 26.66 10.67 3 321878 9215 79413292
Hyperosmolar state 26.45 10.67 22 321859 661 79421846
Personality disorder 26.39 10.67 69 321812 6077 79416430
Meconium in amniotic fluid 26.35 10.67 12 321869 115 79422392
Metastases to lymph nodes 26.33 10.67 5 321876 10392 79412115
Respiratory tract congestion 26.30 10.67 25 321856 19929 79402578
Joint stiffness 26.28 10.67 81 321800 40749 79381758
Borderline personality disorder 26.23 10.67 25 321856 902 79421605
Red blood cell count decreased 26.21 10.67 131 321750 57382 79365125
Water intoxication 26.04 10.67 23 321858 751 79421756
Enterocolitis 26.01 10.67 13 321868 14499 79408008
Limb discomfort 25.83 10.67 59 321822 32791 79389716
C-reactive protein increased 25.74 10.67 366 321515 128661 79293846
Eye movement disorder 25.72 10.67 81 321800 7930 79414577
Obsessive-compulsive personality disorder 25.65 10.67 12 321869 123 79422384
Patient uncooperative 25.60 10.67 22 321859 692 79421815
Sneezing 25.55 10.67 25 321856 19658 79402849
Oral discharge 25.52 10.67 15 321866 253 79422254
Foetal death 25.52 10.67 81 321800 7963 79414544
Impaired self-care 25.48 10.67 42 321839 2665 79419842
Haematoma 25.47 10.67 116 321765 52079 79370428
Abdominal distension 25.45 10.67 335 321546 119315 79303192
Post-traumatic stress disorder 25.42 10.67 59 321822 4822 79417685
Ear infection 25.36 10.67 64 321817 34368 79388139
Oral herpes 25.27 10.67 45 321836 27409 79395098
Cataract 25.26 10.67 147 321734 61973 79360534
Excessive masturbation 25.24 10.67 11 321870 94 79422413
Anion gap increased 25.17 10.67 50 321831 3670 79418837
Postmortem blood drug level increased 25.16 10.67 23 321858 786 79421721
Dry mouth 25.15 10.67 497 321384 87522 79334985
Skin infection 25.07 10.67 22 321859 18223 79404284
Asthma 24.95 10.67 389 321492 134706 79287801
Cardiac failure chronic 24.93 10.67 7 321874 11128 79411379
Laboratory test abnormal 24.90 10.67 47 321834 28001 79394506
Dissociative disorder 24.87 10.67 23 321858 798 79421709
Persistent genital arousal disorder 24.87 10.67 15 321866 266 79422241
Total lung capacity increased 24.86 10.67 38 321843 2260 79420247
Joint injury 24.86 10.67 56 321825 31279 79391228
Seasonal allergy 24.78 10.67 18 321863 16388 79406119
Waxy flexibility 24.77 10.67 15 321866 268 79422239
Pulmonary oedema 24.76 10.67 232 321649 88022 79334485
Femur fracture 24.65 10.67 77 321804 38575 79383932
Thrombotic microangiopathy 24.62 10.67 27 321854 20142 79402365
Pneumonia bacterial 24.58 10.67 25 321856 19306 79403201
Blood iron decreased 24.55 10.67 16 321865 15418 79407089
Cardiac tamponade 24.50 10.67 4 321877 9272 79413235
Penile haemorrhage 24.41 10.67 19 321862 518 79421989
Psychotic disorder due to a general medical condition 24.38 10.67 15 321866 276 79422231
Cervix neoplasm 24.37 10.67 13 321868 180 79422327
Compulsions 24.33 10.67 17 321864 391 79422116
Posterior reversible encephalopathy syndrome 24.26 10.67 43 321838 26238 79396269
Wrong dose 24.22 10.67 32 321849 1662 79420845
Hernia 24.14 10.67 20 321861 17039 79405468
Pneumonia viral 24.07 10.67 4 321877 9154 79413353
Haemorrhage intracranial 24.05 10.67 43 321838 26150 79396357
Transient ischaemic attack 24.03 10.67 120 321761 52575 79369932
Erectile dysfunction 24.01 10.67 120 321761 14544 79407963
Therapeutic product ineffective 24.00 10.67 34 321847 1888 79420619
Eosinopenia 23.93 10.67 9 321872 50 79422457
Therapy cessation 23.84 10.67 75 321806 37487 79385020
Infective pulmonary exacerbation of cystic fibrosis 23.82 10.67 11 321870 12840 79409667
Conjunctivitis 23.80 10.67 42 321839 25673 79396834
Stoma site infection 23.75 10.67 30 321851 1490 79421017
Food refusal 23.71 10.67 19 321862 541 79421966
Haemolysis 23.69 10.67 11 321870 12801 79409706
Osteoporosis 23.67 10.67 125 321756 53987 79368520
Overweight 23.66 10.67 52 321829 4098 79418409
Ileus paralytic 23.65 10.67 89 321792 9531 79412976
Injection site haemorrhage 23.62 10.67 48 321833 27822 79394685
Ventricular arrhythmia 23.60 10.67 84 321797 8756 79413751
Abnormal dreams 23.58 10.67 100 321781 11312 79411195
Brain hypoxia 23.58 10.67 24 321857 939 79421568
Abscess 23.58 10.67 35 321846 22916 79399591
Conduction disorder 23.56 10.67 46 321835 3333 79419174
Gaze palsy 23.55 10.67 43 321838 2962 79419545
Hypervigilance 23.44 10.67 18 321863 481 79422026
Chorea 23.43 10.67 38 321843 2379 79420128
Muscle disorder 23.42 10.67 63 321818 5644 79416863
Treatment failure 23.35 10.67 517 321364 169969 79252538
Illness anxiety disorder 23.27 10.67 14 321867 247 79422260
Autoimmune disorder 23.13 10.67 130 321751 16482 79406025
Compulsive shopping 23.07 10.67 22 321859 794 79421713
Osteopenia 23.06 10.67 24 321857 18340 79404167
Neurological symptom 23.06 10.67 83 321798 8700 79413807
Spinal stenosis 22.98 10.67 18 321863 15773 79406734
Brachial plexopathy 22.96 10.67 12 321869 159 79422348
Multiple sclerosis relapse 22.96 10.67 103 321778 46430 79376077
Drug use disorder 22.93 10.67 82 321799 8569 79413938
Unevaluable event 22.89 10.67 131 321750 55454 79367053
Blood urea increased 22.88 10.67 110 321771 48680 79373827
Intentional medical device removal by patient 22.79 10.67 16 321865 371 79422136
Kidney infection 22.76 10.67 33 321848 21818 79400689
Device malfunction 22.73 10.67 32 321849 21416 79401091
Cholecystitis acute 22.71 10.67 13 321868 13438 79409069
Respiratory distress 22.70 10.67 140 321741 58199 79364308
Musculoskeletal discomfort 22.65 10.67 28 321853 19807 79402700
Staphylococcal parotitis 22.58 10.67 5 321876 0 79422507
Gastrointestinal toxicity 22.56 10.67 3 321878 8106 79414401
Tonic clonic movements 22.50 10.67 36 321845 2228 79420279
Spasmodic dysphonia 22.46 10.67 14 321867 264 79422243
Blood uric acid increased 22.43 10.67 13 321868 13347 79409160
Rapid eye movement sleep behaviour disorder 22.31 10.67 17 321864 449 79422058
Labelled drug-food interaction issue 22.29 10.67 8 321873 38 79422469
Multiple fractures 22.26 10.67 3 321878 8023 79414484
Atelectasis 22.21 10.67 62 321819 32195 79390312
Bacterial parotitis 22.12 10.67 8 321873 39 79422468
Decreased bronchial secretion 22.07 10.67 9 321872 64 79422443
Graft versus host disease 22.03 10.67 17 321864 15009 79407498
Facial spasm 21.98 10.67 21 321860 760 79421747
Hostility 21.96 10.67 36 321845 2274 79420233
Choking 21.96 10.67 102 321779 11999 79410508
Postmortem blood drug level 21.93 10.67 15 321866 333 79422174
Rotator cuff syndrome 21.90 10.67 15 321866 14080 79408427
Feeling hot 21.88 10.67 146 321735 59588 79362919
Aplastic anaemia 21.82 10.67 24 321857 17881 79404626
Urine alcohol test positive 21.75 10.67 7 321874 22 79422485
Adulterated product 21.74 10.67 14 321867 280 79422227
Food craving 21.71 10.67 30 321851 1627 79420880
Pancreatic carcinoma 21.70 10.67 14 321867 13563 79408944
Frequent bowel movements 21.68 10.67 55 321826 29484 79393023
Cerebral haemorrhage 21.62 10.67 140 321741 57533 79364974
Stoma site pain 21.56 10.67 28 321853 1430 79421077
Neonatal infection 21.52 10.67 7 321874 23 79422484
Parkinson's disease 21.52 10.67 30 321851 1641 79420866
Respiratory acidosis 21.51 10.67 96 321785 11104 79411403
Contraindicated product administered 21.50 10.67 478 321403 157060 79265447
Antisocial behaviour 21.46 10.67 20 321861 701 79421806
Choreoathetosis 21.44 10.67 29 321852 1541 79420966
Dermatitis 21.43 10.67 33 321848 21288 79401219
Nystagmus 21.42 10.67 88 321793 9816 79412691
Enthesopathy 21.41 10.67 10 321871 11598 79410909
Rhinitis 21.40 10.67 17 321864 14790 79407717
Flashback 21.31 10.67 14 321867 290 79422217
Megacolon 21.31 10.67 45 321836 3450 79419057
Intestinal pseudo-obstruction 21.30 10.67 38 321843 2571 79419936
Contusion 21.29 10.67 448 321433 148328 79274179
Aphasia 21.27 10.67 285 321596 46447 79376060
Movement disorder 21.17 10.67 185 321696 27074 79395433
Rash macular 21.07 10.67 54 321827 28845 79393662
Sexual abuse 21.05 10.67 13 321868 241 79422266
Urine output decreased 21.05 10.67 25 321856 17997 79404510
Fibromyalgia 21.05 10.67 371 321510 63969 79358538
Pyelonephritis 21.03 10.67 31 321850 20357 79402150
Helplessness 21.03 10.67 15 321866 357 79422150
Bronchospasm 20.91 10.67 43 321838 24816 79397691
Respiratory syncytial virus infection 20.89 10.67 6 321875 9396 79413111
Grandiosity 20.87 10.67 18 321863 569 79421938
Inappropriate schedule of product administration 20.74 10.67 397 321484 133231 79289276
Post procedural infection 20.70 10.67 10 321871 11374 79411133
Agranulocytosis 20.65 10.67 275 321606 44755 79377752
Antidepressant drug level increased 20.57 10.67 16 321865 436 79422071
Ill-defined disorder 20.32 10.67 169 321712 65706 79356801
Eye haemorrhage 20.29 10.67 7 321874 9750 79412757
Epstein-Barr virus infection 20.27 10.67 17 321864 14399 79408108
Bacterial infection 20.17 10.67 62 321819 31218 79391289
Skin mass 20.16 10.67 4 321877 8059 79414448
Vasoplegia syndrome 20.15 10.67 45 321836 3585 79418922
Polyneuropathy 20.12 10.67 42 321839 24109 79398398
Bladder dilatation 20.11 10.67 33 321848 2086 79420421
Lymphopenia 20.11 10.67 60 321821 30497 79392010
Sedation complication 20.11 10.67 120 321761 15549 79406958
Labelled drug-food interaction medication error 20.09 10.67 11 321870 161 79422346
Electrocardiogram ST segment elevation 20.08 10.67 77 321804 8320 79414187
Tendon rupture 20.08 10.67 12 321869 12114 79410393
Drug eruption 20.06 10.67 100 321781 43835 79378672
Heparin-induced thrombocytopenia 20.04 10.67 7 321874 9675 79412832
Gastric cancer 20.00 10.67 8 321873 10171 79412336
Breath sounds abnormal 19.95 10.67 21 321860 15963 79406544
Eosinophilic pleural effusion 19.93 10.67 14 321867 325 79422182
Dry eye 19.92 10.67 79 321802 36852 79385655
Breast discharge 19.83 10.67 19 321862 690 79421817
Rib fracture 19.78 10.67 53 321828 27894 79394613
Maternal exposure during pregnancy 19.76 10.67 705 321176 135833 79286674
Communication disorder 19.74 10.67 48 321833 4042 79418465
Renal tubular necrosis 19.66 10.67 45 321836 24994 79397513
Orthopnoea 19.65 10.67 8 321873 10065 79412442
Radial nerve palsy 19.57 10.67 16 321865 469 79422038
Metabolic encephalopathy 19.56 10.67 81 321800 9066 79413441
Dysphagia 19.53 10.67 638 321243 121498 79301009
Gastrointestinal necrosis 19.48 10.67 58 321823 5507 79417000
Lung adenocarcinoma 19.46 10.67 4 321877 7860 79414647
Pulmonary alveolar haemorrhage 19.45 10.67 11 321870 11446 79411061
Intervertebral disc degeneration 19.41 10.67 21 321860 15764 79406743
Guillain-Barre syndrome 19.41 10.67 6 321875 8959 79413548
Facial pain 19.38 10.67 13 321868 12337 79410170
Electroencephalogram abnormal 19.37 10.67 57 321824 5377 79417130
Breast engorgement 19.37 10.67 8 321873 59 79422448
Encephalitis toxic 19.35 10.67 13 321868 280 79422227
Multiple allergies 19.31 10.67 9 321872 10451 79412056
Hospitalisation 19.26 10.67 266 321615 93970 79328537
Abnormal loss of weight 19.25 10.67 5 321876 8371 79414136
Aortic arteriosclerosis 19.25 10.67 6 321875 8912 79413595
Nail disorder 19.25 10.67 12 321869 11840 79410667
Brain natriuretic peptide increased 19.19 10.67 6 321875 8894 79413613
Lupus vulgaris 19.16 10.67 42 321839 3304 79419203
Sense of a foreshortened future 19.14 10.67 5 321876 5 79422502
Aphthous ulcer 19.12 10.67 24 321857 16865 79405642
Gastrointestinal hypomotility 19.10 10.67 31 321850 1942 79420565
Small intestinal obstruction 19.09 10.67 52 321829 27220 79395287
Renal papillary necrosis 19.09 10.67 15 321866 415 79422092
Alanine aminotransferase abnormal 19.08 10.67 6 321875 8861 79413646
False positive investigation result 19.07 10.67 23 321858 1089 79421418
Distractibility 19.03 10.67 19 321862 726 79421781
Somatic symptom disorder of pregnancy 19.01 10.67 9 321872 95 79422412
Musculoskeletal disorder 18.99 10.67 36 321845 21412 79401095
Drug withdrawal syndrome neonatal 18.95 10.67 13 321868 290 79422217
Wrong patient 18.89 10.67 14 321867 354 79422153
Arthritis infective 18.89 10.67 5 321876 8266 79414241
Incorrect route of product administration 18.89 10.67 220 321661 34709 79387798
Feeling jittery 18.89 10.67 102 321779 12739 79409768
Blood alkaline phosphatase increased 18.89 10.67 165 321716 63499 79359008
Faecal vomiting 18.87 10.67 23 321858 1101 79421406
Fear of weight gain 18.85 10.67 6 321875 18 79422489
IVth nerve disorder 18.85 10.67 6 321875 18 79422489
Peripheral arterial occlusive disease 18.85 10.67 5 321876 8253 79414254
SARS-CoV-2 test positive 18.84 10.67 12 321869 11704 79410803
Blood osmolarity decreased 18.81 10.67 25 321856 1306 79421201
Obsessive-compulsive symptom 18.75 10.67 11 321870 185 79422322
Osteoarthritis 18.73 10.67 244 321637 87065 79335442
Alanine aminotransferase increased 18.71 10.67 506 321375 162064 79260443
Lung neoplasm malignant 18.71 10.67 54 321827 27738 79394769
Dopamine dysregulation syndrome 18.68 10.67 16 321865 501 79422006
Device kink 18.65 10.67 30 321851 1865 79420642
Bacterial sepsis 18.64 10.67 5 321876 8193 79414314
Cerebral infarction 18.62 10.67 108 321773 45568 79376939
Depressive delusion 18.61 10.67 6 321875 19 79422488
Postoperative wound infection 18.58 10.67 15 321866 12946 79409561
Alcohol use 18.51 10.67 52 321829 4779 79417728
Retrograde ejaculation 18.49 10.67 13 321868 302 79422205
Peritonitis 18.49 10.67 55 321826 27981 79394526
Hepatic failure 18.45 10.67 158 321723 61054 79361453
Gastrointestinal sounds abnormal 18.42 10.67 56 321825 5379 79417128
Infusion site pain 18.41 10.67 18 321863 14158 79408349
Tooth abscess 18.39 10.67 23 321858 16187 79406320
Cardiac disorder 18.39 10.67 173 321708 65584 79356923
Poor venous access 18.33 10.67 28 321853 18121 79404386
Musculoskeletal chest pain 18.26 10.67 46 321835 24718 79397789
Formication 18.21 10.67 53 321828 4970 79417537
Claustrophobia 18.18 10.67 24 321857 1246 79421261
Aortic stenosis 18.16 10.67 4 321877 7491 79415016
Fear of injection 18.09 10.67 4 321877 7470 79415037
Buccoglossal syndrome 18.07 10.67 4 321877 0 79422507
Synovial cyst 18.06 10.67 9 321872 10056 79412451
Deafness 18.03 10.67 36 321845 21001 79401506
Peritonitis bacterial 18.02 10.67 8 321873 9559 79412948
Phaeochromocytoma malignant 18.00 10.67 8 321873 72 79422435
Enterococcal infection 17.99 10.67 22 321859 15638 79406869
Psychogenic tremor 17.95 10.67 6 321875 22 79422485
Generalised anxiety disorder 17.93 10.67 32 321849 2165 79420342
Gingival pain 17.80 10.67 7 321874 8991 79413516
Abdominal pain lower 17.77 10.67 67 321814 31715 79390792
Hyperuricaemia 17.75 10.67 13 321868 11786 79410721
Haematocrit decreased 17.71 10.67 160 321721 61152 79361355
Arterial occlusive disease 17.70 10.67 6 321875 8450 79414057
Lung disorder 17.70 10.67 224 321657 80333 79342174
Complication associated with device 17.66 10.67 27 321854 17469 79405038
Constipation 17.65 10.67 948 320933 282102 79140405
Epigastric discomfort 17.61 10.67 5 321876 7891 79414616
Paraesthesia oral 17.57 10.67 35 321846 20436 79402071
Hydronephrosis 17.56 10.67 27 321854 17427 79405080
Cardiac failure acute 17.44 10.67 31 321850 18898 79403609
Hallucination, olfactory 17.42 10.67 15 321866 473 79422034
Camptocormia 17.42 10.67 15 321866 473 79422034
Chromaturia 17.35 10.67 50 321831 25696 79396811
Parosmia 17.34 10.67 65 321816 6949 79415558
Painful erection 17.32 10.67 10 321871 163 79422344
Spinal compression fracture 17.28 10.67 26 321855 16932 79405575
Blood lactic acid increased 17.26 10.67 99 321782 12645 79409862
Verbal abuse 17.25 10.67 12 321869 274 79422233
Epidermolysis bullosa 17.21 10.67 11 321870 217 79422290
Bladder prolapse 17.19 10.67 25 321856 1422 79421085
Neurodegenerative disorder 17.18 10.67 15 321866 482 79422025
Multiple-drug resistance 17.18 10.67 7 321874 8801 79413706
Confabulation 17.16 10.67 15 321866 483 79422024
Congenital cerebrovascular anomaly 17.13 10.67 5 321876 10 79422497
Conjunctival abrasion 17.13 10.67 5 321876 10 79422497
Blindness 17.09 10.67 58 321823 28325 79394182
X-ray abnormal 17.06 10.67 57 321824 5756 79416751
Joint effusion 17.06 10.67 29 321852 17985 79404522
Dislocation of vertebra 17.03 10.67 70 321811 7810 79414697
Coordination abnormal 17 10.67 124 321757 17188 79405319
Lack of spontaneous speech 16.95 10.67 11 321870 223 79422284
Heart rate irregular 16.93 10.67 71 321810 32608 79389899
Initial insomnia 16.90 10.67 64 321817 6874 79415633
Blood potassium decreased 16.88 10.67 114 321767 46398 79376109
Hypernatraemia 16.86 10.67 108 321773 14343 79408164
Subarachnoid haemorrhage 16.86 10.67 47 321834 24418 79398089
Endocarditis 16.84 10.67 11 321870 10586 79411921
Stoma site extravasation 16.78 10.67 13 321868 352 79422155
Duodenal ulcer 16.78 10.67 25 321856 16344 79406163
Eye swelling 16.69 10.67 53 321828 26415 79396092
Renal tubular disorder 16.68 10.67 3 321878 6483 79416024
Large intestine polyp 16.66 10.67 16 321865 12692 79409815
Drug resistance 16.58 10.67 101 321780 42112 79380395
Immune thrombocytopenia 16.55 10.67 29 321852 17776 79404731
Polyp 16.55 10.67 6 321875 8101 79414406
Groin pain 16.53 10.67 17 321864 13063 79409444
Hyperglycaemia 16.50 10.67 386 321495 69949 79352558
Proctalgia 16.42 10.67 10 321871 9991 79412516
Lacrimation increased 16.38 10.67 42 321839 22435 79400072
Herpes simplex 16.38 10.67 15 321866 12172 79410335
Libido decreased 16.35 10.67 53 321828 5268 79417239
Paralysis 16.33 10.67 100 321781 13077 79409430
Anamnestic reaction 16.31 10.67 6 321875 31 79422476
Gastritis erosive 16.25 10.67 12 321869 10835 79411672
Hepatic encephalopathy 16.23 10.67 47 321834 24119 79398388
Graft versus host disease in gastrointestinal tract 16.22 10.67 3 321878 6353 79416154
Drug level above therapeutic 16.18 10.67 74 321807 8649 79413858
Visceral pain 16.15 10.67 8 321873 94 79422413
Ejaculation disorder 16.14 10.67 15 321866 524 79421983
Gait disturbance 16.13 10.67 1007 320874 206499 79216008
Migraine 16.13 10.67 252 321629 87241 79335266
Foot fracture 16.08 10.67 41 321840 21940 79400567
Ocular hyperaemia 16.07 10.67 59 321822 28147 79394360
Foot deformity 16.04 10.67 47 321834 24027 79398480
Metastasis 16.02 10.67 4 321877 6876 79415631
Hyperthermia malignant 16.01 10.67 36 321845 2881 79419626
Starvation ketoacidosis 16.01 10.67 9 321872 139 79422368
Poor quality sleep 16.01 10.67 151 321730 22571 79399936
Gait deviation 15.95 10.67 7 321874 61 79422446
Intermittent explosive disorder 15.84 10.67 4 321877 3 79422504
Spinal disorder 15.83 10.67 11 321870 10249 79412258
Shock haemorrhagic 15.79 10.67 36 321845 20024 79402483
Thermal burn 15.78 10.67 64 321817 7096 79415411
Electroconvulsive therapy 15.78 10.67 8 321873 99 79422408
Asthma-chronic obstructive pulmonary disease overlap syndrome 15.76 10.67 38 321843 3183 79419324
Anosmia 15.73 10.67 8 321873 8836 79413671
Violence-related symptom 15.72 10.67 17 321864 714 79421793
Haemolytic anaemia 15.70 10.67 30 321851 17790 79404717
Thrombotic thrombocytopenic purpura 15.69 10.67 59 321822 6317 79416190
Delusion of reference 15.68 10.67 9 321872 145 79422362
Hyponatraemic coma 15.66 10.67 7 321874 64 79422443
Hepatitis B 15.65 10.67 7 321874 8325 79414182
Immunodeficiency 15.62 10.67 41 321840 21727 79400780
Ketoacidosis 15.60 10.67 68 321813 7786 79414721
Pseudomonal sepsis 15.57 10.67 3 321878 6171 79416336
Retinal detachment 15.52 10.67 9 321872 9238 79413269
Nephrogenic systemic fibrosis 15.52 10.67 3 321878 6157 79416350
Ear pain 15.48 10.67 74 321807 32795 79389712
Mitral valve incompetence 15.47 10.67 61 321820 28504 79394003
Head titubation 15.44 10.67 19 321862 919 79421588
Paraesthesia 15.41 10.67 569 321312 175754 79246753
Panic disorder 15.40 10.67 36 321845 2956 79419551
Pathological fracture 15.35 10.67 12 321869 10525 79411982
Spinal pain 15.30 10.67 24 321857 15368 79407139
Autoimmune hepatitis 15.25 10.67 15 321866 11768 79410739
Apnoea 15.25 10.67 90 321791 11614 79410893
Electrocardiogram change 15.16 10.67 22 321859 1249 79421258
Crepitations 15.12 10.67 11 321870 10006 79412501
Poriomania 15.02 10.67 10 321871 212 79422295
Muscle spasticity 14.99 10.67 41 321840 21434 79401073
Portal hypertension 14.96 10.67 5 321876 7103 79415404
Escherichia bacteraemia 14.93 10.67 4 321877 6558 79415949
Delusion of replacement 14.90 10.67 9 321872 160 79422347
Agitated depression 14.89 10.67 13 321868 418 79422089
Gestational hypertension 14.87 10.67 27 321854 1852 79420655
Hepatocellular carcinoma 14.83 10.67 9 321872 9012 79413495
Selective mutism 14.77 10.67 7 321874 74 79422433
Cytomegalovirus test positive 14.77 10.67 3 321878 5944 79416563
Brachial plexus injury 14.73 10.67 8 321873 115 79422392
Prescription drug used without a prescription 14.71 10.67 43 321838 4042 79418465
Peripheral vascular disorder 14.69 10.67 7 321874 8023 79414484
Rebound effect 14.69 10.67 63 321818 7163 79415344
CADASIL 14.67 10.67 6 321875 43 79422464
Glomerular filtration rate decreased 14.64 10.67 45 321836 22657 79399850
Staphylococcal sepsis 14.60 10.67 23 321858 14703 79407804
Wrong technique in product usage process 14.57 10.67 210 321671 73665 79348842
Spinal fracture 14.54 10.67 32 321849 18022 79404485
Intellectual disability 14.53 10.67 22 321859 1298 79421209
Regressive behaviour 14.52 10.67 9 321872 168 79422339
Eye infection 14.50 10.67 16 321865 11904 79410603
Aortic aneurysm 14.50 10.67 8 321873 8438 79414069
Flat affect 14.49 10.67 28 321853 2013 79420494
Off label use 14.47 10.67 3343 318538 903872 78518635
Drug dispensed to wrong patient 14.46 10.67 16 321865 690 79421817
Total cholesterol/HDL ratio abnormal 14.45 10.67 7 321874 78 79422429
Iron deficiency 14.45 10.67 13 321868 10641 79411866
Fear 14.45 10.67 144 321737 21842 79400665
Scoliosis 14.45 10.67 6 321875 7458 79415049
Indifference 14.39 10.67 11 321870 292 79422215
Tourette's disorder 14.38 10.67 7 321874 79 79422428
Cardiopulmonary failure 14.37 10.67 60 321821 6741 79415766
Sickle cell anaemia with crisis 14.34 10.67 7 321874 7915 79414592
Hypoaesthesia 14.31 10.67 585 321296 178767 79243740
Hyperphosphataemia 14.29 10.67 4 321877 6372 79416135
Polymerase chain reaction 14.26 10.67 8 321873 123 79422384
Lipase increased 14.26 10.67 28 321853 16438 79406069
Neuroleptic-induced deficit syndrome 14.24 10.67 5 321876 22 79422485
Tricuspid valve incompetence 14.24 10.67 37 321844 19675 79402832
Asocial behaviour 14.22 10.67 7 321874 81 79422426
End stage renal disease 14.22 10.67 17 321864 12203 79410304
Splenomegaly 14.21 10.67 40 321841 20714 79401793
Ankylosing spondylitis 14.18 10.67 17 321864 12188 79410319
Product prescribing error 14.16 10.67 257 321624 44556 79377951
Protein urine present 14.13 10.67 12 321869 10100 79412407
Arteriosclerosis 14.12 10.67 33 321848 18194 79404313
Stoma site induration 14.11 10.67 6 321875 48 79422459
Breast enlargement 14.09 10.67 24 321857 1565 79420942
Eye irritation 14.05 10.67 40 321841 20641 79401866
Medical device site injury 14.05 10.67 4 321877 7 79422500
Infusion site swelling 14.04 10.67 7 321874 7819 79414688
Orthostatic hypotension 14.04 10.67 311 321570 55853 79366654
Blood sodium increased 14.04 10.67 47 321834 4751 79417756
Fistula 14.02 10.67 19 321862 12921 79409586
Pupillary light reflex tests abnormal 14.01 10.67 11 321870 304 79422203
Discoloured vomit 14.00 10.67 23 321858 1455 79421052
Catheterisation cardiac 14.00 10.67 3 321878 5725 79416782
Hysterectomy 13.94 10.67 4 321877 6268 79416239
Arthritis bacterial 13.92 10.67 10 321871 9156 79413351
Drug dose omission by device 13.86 10.67 4 321877 6246 79416261
Dialysis 13.84 10.67 34 321847 18428 79404079
Neutropenia 13.84 10.67 987 320894 286723 79135784
Parainfluenzae virus infection 13.83 10.67 3 321878 5679 79416828
Meniscus injury 13.83 10.67 5 321876 6763 79415744
Gingival bleeding 13.82 10.67 28 321853 16248 79406259
Toxic skin eruption 13.80 10.67 45 321836 22248 79400259
Retinal haemorrhage 13.79 10.67 8 321873 8209 79414298
Diarrhoea haemorrhagic 13.77 10.67 20 321861 13214 79409293
Encopresis 13.77 10.67 8 321873 132 79422375
Blood pressure diastolic decreased 13.67 10.67 69 321812 30147 79392360
Dysmetropsia 13.58 10.67 7 321874 90 79422417
Breast cancer metastatic 13.57 10.67 9 321872 8593 79413914
CSWS syndrome 13.56 10.67 5 321876 26 79422481
Lack of satiety 13.55 10.67 3 321878 0 79422507
Erotomanic delusion 13.55 10.67 3 321878 0 79422507
Antidepressant drug level 13.55 10.67 3 321878 0 79422507
Bulimia nervosa 13.52 10.67 10 321871 252 79422255
Nephropathy toxic 13.51 10.67 40 321841 20379 79402128
Thyroid cancer 13.50 10.67 3 321878 5585 79416922
Infusion site erythema 13.50 10.67 11 321870 9449 79413058
Peripheral ischaemia 13.49 10.67 11 321870 9446 79413061
Gastrointestinal perforation 13.48 10.67 4 321877 6133 79416374
Electrocardiogram T wave inversion 13.46 10.67 50 321831 5322 79417185
Pulmonary function test decreased 13.45 10.67 7 321874 7630 79414877
Gallbladder disorder 13.44 10.67 37 321844 19303 79403204
Metabolic acidosis 13.42 10.67 432 321449 82097 79340410
Salivary gland calculus 13.42 10.67 10 321871 255 79422252
Impaired work ability 13.42 10.67 38 321843 19643 79402864
Pain of skin 13.41 10.67 24 321857 14589 79407918
Atrial tachycardia 13.38 10.67 6 321875 7127 79415380
Asterixis 13.31 10.67 32 321849 2675 79419832
Amimia 13.31 10.67 6 321875 56 79422451
Urine sodium increased 13.31 10.67 9 321872 196 79422311
Coronary artery occlusion 13.30 10.67 26 321855 15289 79407218
Induced abortion failed 13.27 10.67 9 321872 197 79422310
Bronchial aspiration procedure 13.26 10.67 10 321871 260 79422247
Haemorrhagic stroke 13.25 10.67 15 321866 11031 79411476
Necrotising fasciitis 13.18 10.67 4 321877 6046 79416461
Metabolic alkalosis 13.16 10.67 44 321837 4445 79418062
Learning disability 13.11 10.67 9 321872 201 79422306
Scab 13.07 10.67 14 321867 10558 79411949
Cerebral amyloid angiopathy 13.07 10.67 11 321870 336 79422171
Flail chest 13.05 10.67 7 321874 98 79422409
Distal intestinal obstruction syndrome 13.05 10.67 16 321865 771 79421736
Respiratory failure 13.00 10.67 597 321284 180314 79242193
Thrombosis in device 12.99 10.67 3 321878 5439 79417068
Subdural haematoma 12.99 10.67 74 321807 31360 79391147
Hyperarousal 12.97 10.67 5 321876 30 79422477
Defect conduction intraventricular 12.95 10.67 13 321868 500 79422007
Finger deformity 12.94 10.67 7 321874 7467 79415040
Female genital tract fistula 12.93 10.67 4 321877 5971 79416536
Product counterfeit 12.93 10.67 10 321871 270 79422237
Anaphylactoid reaction 12.92 10.67 3 321878 5419 79417088
Staphylococcus test positive 12.89 10.67 5 321876 6476 79416031
Spinal operation 12.88 10.67 8 321873 7909 79414598
Sleep disorder due to general medical condition, insomnia type 12.87 10.67 113 321768 43443 79379064
Patient isolation 12.87 10.67 6 321875 61 79422446
Spinal osteoarthritis 12.83 10.67 31 321850 16896 79405611
Palpitations 12.82 10.67 401 321480 126209 79296298
Eosinophilic cellulitis 12.81 10.67 7 321874 102 79422405
Renal cyst 12.80 10.67 25 321856 14707 79407800
Hyperchloraemia 12.79 10.67 19 321862 1102 79421405
Upper limb fracture 12.77 10.67 34 321847 17933 79404574
Haematemesis 12.76 10.67 142 321739 52122 79370385
Bone lesion 12.74 10.67 4 321877 5915 79416592
Liver function test increased 12.74 10.67 101 321780 39672 79382835
Feminisation acquired 12.70 10.67 5 321876 32 79422475
Muscle atrophy 12.67 10.67 16 321865 11216 79411291
Dermatitis exfoliative 12.67 10.67 15 321866 10814 79411693
Drug abuser 12.67 10.67 53 321828 5960 79416547
Granuloma 12.67 10.67 9 321872 8288 79414219
Postoperative respiratory failure 12.66 10.67 9 321872 213 79422294
Idiopathic intracranial hypertension 12.66 10.67 35 321846 3187 79419320
Central nervous system injury 12.64 10.67 8 321873 155 79422352
Skin papilloma 12.63 10.67 4 321877 5882 79416625
Ischaemic stroke 12.63 10.67 80 321801 33051 79389456
Mental disability 12.62 10.67 6 321875 64 79422443
Mixed dementia 12.59 10.67 10 321871 281 79422226
Bone marrow eosinophilic leukocyte count increased 12.58 10.67 5 321876 33 79422474
Lung perforation 12.57 10.67 7 321874 106 79422401
Crush injury 12.57 10.67 4 321877 12 79422495
Forced expiratory volume decreased 12.57 10.67 8 321873 7806 79414701
Nonspecific reaction 12.53 10.67 30 321851 2502 79420005
Bone erosion 12.51 10.67 34 321847 17813 79404694
Hyperkeratosis 12.49 10.67 8 321873 7782 79414725
Aortic valve stenosis 12.48 10.67 3 321878 5291 79417216
Cyanosis 12.48 10.67 156 321725 25026 79397481
Mass 12.47 10.67 33 321848 17439 79405068
Portal vein thrombosis 12.43 10.67 4 321877 5823 79416684
Skin fissures 12.42 10.67 21 321860 13052 79409455
Tooth fracture 12.42 10.67 17 321864 11513 79410994
Needle issue 12.41 10.67 21 321860 13047 79409460
Rash papular 12.38 10.67 46 321835 21870 79400637
Cataplexy 12.38 10.67 17 321864 917 79421590
Substance use 12.38 10.67 17 321864 917 79421590
Ovarian cyst 12.33 10.67 20 321861 12635 79409872
Peripheral sensory neuropathy 12.32 10.67 21 321860 13012 79409495
Cortisol increased 12.30 10.67 13 321868 532 79421975
Tri-iodothyronine decreased 12.27 10.67 10 321871 292 79422215
Diabetic complication 12.25 10.67 20 321861 1259 79421248
Immobilisation prolonged 12.24 10.67 7 321874 112 79422395
Posturing 12.23 10.67 18 321863 1035 79421472
Wrong product administered 12.20 10.67 70 321811 8942 79413565
Eyelid ptosis 12.19 10.67 16 321865 11028 79411479
Echolalia 12.16 10.67 11 321870 371 79422136
Premature delivery 12.15 10.67 51 321830 23416 79399091
Vitamin K decreased 12.15 10.67 6 321875 70 79422437
Delusional disorder, erotomanic type 12.09 10.67 5 321876 37 79422470
Tooth extraction 12.06 10.67 16 321865 10979 79411528
Neutropenic colitis 12.03 10.67 4 321877 5703 79416804
Thought blocking 12.03 10.67 9 321872 231 79422276
Anal abscess 12.01 10.67 12 321869 9343 79413164
Malignant polyp 12.00 10.67 8 321873 170 79422337
Duodenal ulcer haemorrhage 11.99 10.67 7 321874 7156 79415351
Pharyngitis 11.98 10.67 48 321833 22327 79400180
Lipids increased 11.96 10.67 23 321858 1648 79420859
Contraindication to medical treatment 11.94 10.67 20 321861 1286 79421221
Blood magnesium decreased 11.92 10.67 31 321850 16481 79406026
Embolism 11.92 10.67 24 321857 13958 79408549
Dysphemia 11.90 10.67 36 321845 3448 79419059
Electrocardiogram ST segment depression 11.89 10.67 45 321836 4833 79417674
Musculoskeletal deformity 11.86 10.67 22 321859 1534 79420973
Oesophageal food impaction 11.84 10.67 11 321870 384 79422123
Infusion site extravasation 11.83 10.67 14 321867 10094 79412413
Weight fluctuation 11.80 10.67 18 321863 11657 79410850
Delirium febrile 11.79 10.67 6 321875 75 79422432
Cerebral atrophy 11.78 10.67 64 321817 8011 79414496
Female sexual dysfunction 11.76 10.67 5 321876 40 79422467
Lymphoedema 11.74 10.67 20 321861 12393 79410114
Tongue paralysis 11.74 10.67 12 321869 472 79422035
Increased tendency to bruise 11.71 10.67 15 321866 10449 79412058
Accidental exposure to product by child 11.71 10.67 32 321849 2894 79419613
Purpura 11.69 10.67 40 321841 19487 79403020
Disturbance in sexual arousal 11.67 10.67 9 321872 242 79422265
Hyperbilirubinaemia 11.66 10.67 55 321826 24463 79398044
Hyperdynamic left ventricle 11.65 10.67 11 321870 392 79422115
Vascular dementia 11.65 10.67 16 321865 863 79421644
Metastatic neoplasm 11.61 10.67 3 321878 5039 79417468
Cyst 11.59 10.67 24 321857 13816 79408691
Diastolic dysfunction 11.59 10.67 16 321865 10795 79411712
Graft versus host disease in skin 11.57 10.67 5 321876 6068 79416439
Soliloquy 11.56 10.67 14 321867 666 79421841
Allergic hepatitis 11.55 10.67 5 321876 42 79422465
Myasthenia gravis 11.54 10.67 15 321866 10384 79412123
Dermatitis acneiform 11.52 10.67 14 321867 9979 79412528
Lactate pyruvate ratio increased 11.51 10.67 6 321875 79 79422428
Carotid artery stenosis 11.51 10.67 11 321870 8747 79413760
Anhedonia 11.51 10.67 101 321780 14797 79407710
Mouth swelling 11.49 10.67 5 321876 6046 79416461
Perinatal depression 11.49 10.67 11 321870 399 79422108
Propulsive gait 11.48 10.67 3 321878 3 79422504
Abortion spontaneous 11.45 10.67 175 321706 29332 79393175
Product quality issue 11.43 10.67 85 321796 33855 79388652
Abnormal clotting factor 11.41 10.67 8 321873 185 79422322
Blood phosphorus increased 11.41 10.67 15 321866 10332 79412175
C-reactive protein 11.37 10.67 45 321836 4934 79417573
Non-cardiac chest pain 11.35 10.67 13 321868 9511 79412996
Azotaemia 11.35 10.67 10 321871 8266 79414241
Pharyngitis streptococcal 11.34 10.67 16 321865 10698 79411809
Compulsive sexual behaviour 11.33 10.67 9 321872 253 79422254
Stress 11.31 10.67 240 321641 79372 79343135
Suspected suicide attempt 11.28 10.67 10 321871 328 79422179
Hyperaesthesia 11.28 10.67 20 321861 12202 79410305
Haemothorax 11.27 10.67 4 321877 5474 79417033
Aplasia pure red cell 11.24 10.67 9 321872 7801 79414706
Product dose omission in error 11.18 10.67 9 321872 7779 79414728
Deafness neurosensory 11.18 10.67 7 321874 6891 79415616
Dermatitis contact 11.16 10.67 17 321864 11016 79411491
Urosepsis 11.15 10.67 62 321819 26433 79396074
Underdose 11.14 10.67 192 321689 32959 79389548
Superinfection 11.13 10.67 3 321878 4899 79417608
Stoma site odour 11.13 10.67 6 321875 85 79422422
Hallucination, tactile 11.11 10.67 13 321868 596 79421911
Gingivitis 11.09 10.67 12 321869 9009 79413498
Hyperglycaemic hyperosmolar nonketotic syndrome 11.09 10.67 27 321854 2276 79420231
Pharyngeal dystonia 11.06 10.67 5 321876 47 79422460
Splenic injury 11.03 10.67 9 321872 263 79422244
Growth hormone deficiency 11.03 10.67 11 321870 420 79422087
Electrolyte substitution therapy 11.02 10.67 3 321878 4 79422503
Hepatic cirrhosis 11.01 10.67 89 321792 34817 79387690
Autism spectrum disorder 11.01 10.67 18 321863 1134 79421373
Photophobia 11.01 10.67 44 321837 20484 79402023
Drug withdrawal headache 11.01 10.67 6 321875 87 79422420
Chronic lymphocytic leukaemia 11.01 10.67 3 321878 4863 79417644
Penile discharge 10.97 10.67 5 321876 48 79422459
Intercepted medication error 10.96 10.67 16 321865 913 79421594
Non-small cell lung cancer 10.95 10.67 6 321875 6354 79416153
Cerebellar atrophy 10.91 10.67 18 321863 1143 79421364
Glycosuria 10.91 10.67 26 321855 2162 79420345
Pleuritic pain 10.90 10.67 15 321866 10137 79412370
Conjunctival haemorrhage 10.90 10.67 5 321876 5860 79416647
Systemic infection 10.89 10.67 14 321867 9738 79412769
Stab wound 10.89 10.67 9 321872 268 79422239
Thrombocytosis 10.87 10.67 11 321870 8515 79413992
Total lung capacity decreased 10.86 10.67 31 321850 2874 79419633
Rapid eye movements sleep abnormal 10.83 10.67 9 321872 270 79422237
Neurological decompensation 10.83 10.67 46 321835 5207 79417300
Hemiplegia 10.82 10.67 28 321853 14911 79407596
Visual acuity reduced 10.81 10.67 72 321809 29397 79393110
Pustular psoriasis 10.80 10.67 3 321878 4803 79417704
Visual impairment 10.79 10.67 286 321595 91845 79330662
Tension headache 10.78 10.67 8 321873 7203 79415304
Carotid artery occlusion 10.78 10.67 9 321872 7638 79414869
Peripheral coldness 10.77 10.67 31 321850 15939 79406568
Respiratory symptom 10.75 10.67 3 321878 4788 79417719
Escherichia infection 10.72 10.67 37 321844 17980 79404527
Benign prostatic hyperplasia 10.72 10.67 19 321862 11593 79410914
Skin haemorrhage 10.70 10.67 20 321861 11961 79410546
Therapeutic response changed 10.69 10.67 19 321862 1282 79421225
Injection site discolouration 10.68 10.67 9 321872 7605 79414902

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 32.67 25.26 21 2171 52 87548
Meconium aspiration syndrome 32.44 25.26 19 2173 37 87563
Hypertonia neonatal 31.07 25.26 39 2153 288 87312
Withdrawal syndrome 26.87 25.26 22 2170 89 87511

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Histone H1.0 Nuclear other Ki 8 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
Transporter Transporter Ki 6.17 CHEMBL

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0123091 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEMBL1200911 ChEMBL_ID
CHEMBL3188993 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 32 sections