quetiapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.653 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.778 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 43.954 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 19.409 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 9.030 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 18.360 % High 1
herg hERG pIC50 5.069 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 8.017 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 30.974 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 7.130 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,PDK2,PDK4,PIK3CB,PRKDC 16
kinase-selectivity-class AXL 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.493 High 1
mh-clint Mouse hepatocyte intrinsic clearance 69.183 High 1
mppb Mouse plasma protein binding (% unbound) 10.090 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.970 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 21.250 % High 1
rh-clint Rat hepatocyte intrinsic clearance 131.220 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 62.620 % High 1
rppb Rat plasma protein binding (% unbound) 11.370 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 403.645 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3703.14 10.39 3886 405050 141172 90078339
Toxicity to various agents 3446.17 10.39 5282 403654 282564 89936947
Suicide attempt 3371.48 10.39 2763 406173 72636 90146875
Intentional overdose 3200.11 10.39 2946 405990 90888 90128623
Sopor 2852.53 10.39 1627 407309 23017 90196494
Drug abuse 2481.90 10.39 2415 406521 79932 90139579
Neuroleptic malignant syndrome 1718.17 10.39 986 407950 14110 90205401
Intentional self-injury 1579.20 10.39 1200 407736 28134 90191377
Overdose 1373.23 10.39 2513 406423 155196 90064315
Somnolence 1114.86 10.39 2727 406209 206357 90013154
Sedation 1092.81 10.39 1214 407722 46957 90172554
Dystonia 1062.91 10.39 758 408178 16061 90203450
Coma 1040.08 10.39 1453 407483 71179 90148332
Electrocardiogram QT prolonged 1008.62 10.39 1430 407506 71026 90148485
Suicidal ideation 942.67 10.39 1399 407537 72456 90147055
Tardive dyskinesia 909.08 10.39 584 408352 10346 90209165
Drug interaction 888.21 10.39 3005 405931 273448 89946063
Dyskinesia 837.69 10.39 926 408010 35608 90183903
Extrapyramidal disorder 714.34 10.39 591 408345 15712 90203799
Parkinsonism 705.77 10.39 552 408384 13513 90205998
Akathisia 696.09 10.39 499 408437 10660 90208851
Gestational diabetes 684.99 10.39 484 408452 10098 90209413
Agitation 675.08 10.39 1140 407796 65958 90153553
Depressed level of consciousness 666.21 10.39 1186 407750 71598 90147913
Blood prolactin abnormal 633.98 10.39 305 408631 2961 90216550
Sexual dysfunction 601.25 10.39 334 408602 4470 90215041
Schizophrenia 580.34 10.39 505 408431 14409 90205102
Mania 573.43 10.39 490 408446 13634 90205877
Serotonin syndrome 560.24 10.39 770 408166 37117 90182394
Liver injury 525.21 10.39 1829 407107 168738 90050773
Cough 506.09 10.39 551 408385 368411 89851100
Anosognosia 499.47 10.39 266 408670 3256 90216255
Dyspnoea 474.49 10.39 2205 406731 878750 89340761
Delusion 470.01 10.39 434 408502 13406 90206105
Prescribed overdose 459.97 10.39 1216 407720 96409 90123102
Disturbance in social behaviour 451.12 10.39 264 408672 3924 90215587
Hallucination, auditory 450.07 10.39 452 408484 15523 90203988
Diarrhoea 435.04 10.39 2476 406460 936714 89282797
Muscle rigidity 433.08 10.39 421 408515 13888 90205623
Arthralgia 428.25 10.39 1933 407003 776589 89442922
Poisoning deliberate 427.35 10.39 446 408490 16040 90203471
Poisoning 420.37 10.39 426 408510 14791 90204720
Delirium 412.04 10.39 1219 407717 103140 90116371
Metabolic disorder 405.01 10.39 307 408629 7163 90212348
Bezoar 400.48 10.39 211 408725 2523 90216988
Disease progression 396.25 10.39 108 408828 156507 90063004
Altered state of consciousness 391.70 10.39 590 408346 30942 90188569
Anaemia 383.73 10.39 625 408311 352177 89867334
Hypomania 380.36 10.39 318 408618 8579 90210932
Intentional product misuse 378.16 10.39 1072 407864 88532 90130979
Cardio-respiratory arrest 372.11 10.39 857 408079 62283 90157228
Malignant neoplasm progression 358.30 10.39 34 408902 106836 90112675
Personality change 353.68 10.39 281 408655 7040 90212471
Febrile neutropenia 353.30 10.39 136 408800 158213 90061298
Aggression 352.83 10.39 514 408422 26154 90193357
Bradyphrenia 352.48 10.39 285 408651 7327 90212184
Tachycardia 347.69 10.39 1522 407414 156151 90063360
Exposure during pregnancy 334.67 10.39 2028 406908 236382 89983129
Hallucination 316.14 10.39 827 408109 65132 90154379
Restlessness 311.37 10.39 570 408366 35150 90184361
Psychotic disorder 309.23 10.39 527 408409 30703 90188808
Back pain 303.51 10.39 608 408328 316567 89902944
Bradykinesia 299.28 10.39 247 408689 6541 90212970
Suspected suicide 296.12 10.39 285 408651 9283 90210228
Sinus tachycardia 291.40 10.39 488 408448 28025 90191486
Hyperprolactinaemia 289.52 10.39 221 408715 5212 90214299
Galactorrhoea 289.27 10.39 208 408728 4464 90215047
Abnormal behaviour 281.90 10.39 424 408512 22204 90197307
Fatigue 276.78 10.39 3613 405323 1150410 89069101
Diabetes mellitus 276.47 10.39 779 408157 64096 90155415
Respiratory arrest 272.16 10.39 517 408419 32794 90186717
COVID-19 267.71 10.39 221 408715 168622 90050889
Neuropathy peripheral 267.47 10.39 142 408794 136828 90082683
Anticholinergic syndrome 261.90 10.39 160 408776 2583 90216928
Nausea 258.91 10.39 3496 405440 1106820 89112691
Urinary tract infection 256.19 10.39 630 408306 305002 89914509
Loss of consciousness 255.75 10.39 1281 407655 138957 90080554
Injection site pain 255.39 10.39 244 408692 173455 90046056
Tremor 253.62 10.39 1362 407574 151811 90067700
Stubbornness 253.31 10.39 88 408848 324 90219187
Sepsis 244.64 10.39 270 408666 179544 90039967
Psoriatic arthropathy 241.51 10.39 1811 407125 226524 89992987
Herpes zoster 236.12 10.39 67 408869 94577 90124934
Catatonia 235.47 10.39 205 408731 5851 90213660
Drug ineffective 234.98 10.39 4624 404312 1379674 88839837
Pain 232.48 10.39 3136 405800 993205 89226306
Metabolic syndrome 227.76 10.39 128 408808 1754 90217757
Psychomotor hyperactivity 227.52 10.39 285 408651 12528 90206983
Injection site erythema 220.67 10.39 84 408852 98418 90121093
Type 2 diabetes mellitus 220.59 10.39 1622 407314 201622 90017889
Confusional state 217.66 10.39 2681 406255 383524 89835987
Influenza 214.98 10.39 187 408749 139077 90080434
Myelosuppression 213.70 10.39 6 408930 53585 90165926
Substance abuse 212.22 10.39 184 408752 5222 90214289
Product dose omission issue 210.97 10.39 646 408290 291041 89928470
Mydriasis 208.32 10.39 296 408640 14716 90204795
Pruritus 206.80 10.39 1512 407424 540013 89679498
Hallucinations, mixed 202.54 10.39 186 408750 5703 90213808
Platelet count decreased 200.63 10.39 193 408743 136776 90082735
Erythema 198.82 10.39 464 408472 228782 89990729
Headache 197.61 10.39 2725 406211 860021 89359490
Chest discomfort 196.88 10.39 200 408736 138165 90081346
Rash 190.41 10.39 2492 406444 793608 89425903
Seizure 189.62 10.39 1259 407677 151370 90068141
Mucosal inflammation 188.79 10.39 20 408916 57605 90161906
Pain in extremity 184.17 10.39 1233 407703 449296 89770215
Oculogyric crisis 183.10 10.39 123 408813 2356 90217155
Paranoia 181.31 10.39 256 408680 12652 90206859
Injection site reaction 178.96 10.39 96 408840 91984 90127527
Myoclonus 177.41 10.39 314 408622 18854 90200657
Bipolar disorder 175.98 10.39 210 408726 8775 90210736
Haemoglobin decreased 174.85 10.39 288 408648 161668 90057843
Pulmonary fibrosis 174.56 10.39 951 407985 106552 90112959
Obesity 173.79 10.39 937 407999 104570 90114941
Deep vein thrombosis postoperative 169.48 10.39 701 408235 70108 90149403
Respiratory depression 169.15 10.39 274 408662 15301 90204210
Disorientation 169.00 10.39 510 408426 43604 90175907
Cardiac failure congestive 168.10 10.39 120 408816 98574 90120937
Anxiety 167.38 10.39 2134 406802 307638 89911873
Myalgia 166.26 10.39 337 408599 174788 90044723
Orthostatic hypertension 165.38 10.39 71 408865 514 90218997
Cardiac arrest 164.84 10.39 920 408016 104015 90115496
Cellulitis 160.96 10.39 107 408829 91230 90128281
Urinary retention 159.59 10.39 452 408484 37292 90182219
Prescribed underdose 159.07 10.39 716 408220 74303 90145208
Rhinorrhoea 158.98 10.39 101 408835 88215 90131296
Lower limb fracture 153.82 10.39 775 408161 84238 90135273
Dry skin 151.43 10.39 106 408830 87967 90131544
Blood creatine phosphokinase increased 151.30 10.39 415 408521 33608 90185903
Pancytopenia 150.28 10.39 193 408743 120070 90099441
Thinking abnormal 149.22 10.39 222 408714 11510 90208001
Disturbance in attention 149.00 10.39 510 408426 46599 90172912
Electrocardiogram QRS complex prolonged 147.64 10.39 174 408762 7174 90212337
Pneumonia 145.58 10.39 2016 406920 636043 89583468
Autoimmune disorder 144.08 10.39 707 408229 76037 90143474
Adjustment disorder with depressed mood 143.89 10.39 572 408364 56181 90163330
Blood prolactin increased 143.19 10.39 124 408812 3513 90215998
Diabetic coma 143.13 10.39 69 408867 673 90218838
Speech disorder 142.87 10.39 492 408444 45093 90174418
Disorganised speech 142.77 10.39 95 408841 1790 90217721
Depersonalisation/derealisation disorder 142.66 10.39 90 408846 1542 90217969
Swollen joint count increased 142.14 10.39 924 408012 110282 90109229
Flushing 141.24 10.39 115 408821 88376 90131135
Withdrawal syndrome 140.76 10.39 313 408623 22211 90197300
Miosis 140.54 10.39 193 408743 9291 90210220
Cogwheel rigidity 140.35 10.39 98 408838 2004 90217507
Atrial fibrillation 138.33 10.39 244 408692 133367 90086144
Pleurothotonus 138.13 10.39 82 408854 1253 90218258
Antipsychotic drug level increased 137.11 10.39 123 408813 3656 90215855
Anaphylactic reaction 136.91 10.39 116 408820 87408 90132103
Chills 135.76 10.39 242 408694 131739 90087772
Malaise 135.60 10.39 1846 407090 584140 89635371
Skin ulcer 135.42 10.39 30 408906 50045 90169466
Lupus vulgaris 133.17 10.39 477 408459 44582 90174929
Weight increased 132.99 10.39 2635 406301 415292 89804219
Unresponsive to stimuli 131.52 10.39 425 408511 37696 90181815
Nasal congestion 131.16 10.39 110 408826 83304 90136207
Acute kidney injury 129.72 10.39 879 408057 319508 89900003
Coma scale abnormal 129.60 10.39 143 408793 5483 90214028
Interstitial lung disease 128.68 10.39 94 408842 76311 90143200
Bone pain 127.38 10.39 60 408876 61923 90157588
Injection site pruritus 127.25 10.39 42 408894 53792 90165719
Epistaxis 126.92 10.39 118 408818 85007 90134504
Restless legs syndrome 124.72 10.39 298 408638 22172 90197339
Colitis 124.50 10.39 81 408855 69861 90149650
Labour complication 122.43 10.39 41 408895 131 90219380
Gastrointestinal haemorrhage 122.16 10.39 136 408800 90112 90129399
Persecutory delusion 121.53 10.39 107 408829 3101 90216410
Psychomotor retardation 121.32 10.39 128 408808 4661 90214850
Foetal death 120.64 10.39 280 408656 20443 90199068
Device expulsion 120.08 10.39 20 408916 40866 90178645
Treatment noncompliance 119.80 10.39 507 408429 51220 90168291
Hallucination, visual 119.39 10.39 298 408638 22794 90196717
Amnesia 119.37 10.39 869 408067 107636 90111875
Irritability 118.90 10.39 393 408543 35269 90184242
Dislocation of vertebra 118.51 10.39 534 408402 55434 90164077
Salivary hypersecretion 118.45 10.39 174 408762 8918 90210593
Injection site swelling 116.84 10.39 62 408874 59777 90159734
Oedema 116.78 10.39 1400 407536 198895 90020616
Road traffic accident 116.13 10.39 858 408078 106768 90112743
Myocardial infarction 114.77 10.39 188 408748 105784 90113727
Foetal exposure during pregnancy 114.51 10.39 440 408496 42535 90176976
Neck pain 113.61 10.39 213 408723 113750 90105761
Obsessive-compulsive disorder 113.42 10.39 120 408816 4384 90215127
Dysarthria 113.25 10.39 517 408419 53965 90165546
Derealisation 112.85 10.39 75 408861 1410 90218101
Dyspnoea exertional 112.83 10.39 96 408840 72192 90147319
Rhabdomyolysis 112.27 10.39 494 408442 50762 90168749
Breast cancer 112.09 10.39 51 408885 53710 90165801
Bradypnoea 111.83 10.39 121 408815 4537 90214974
Plasma cell myeloma 111.34 10.39 24 408912 40804 90178707
Hyperreflexia 110.19 10.39 143 408793 6514 90212997
Hyperammonaemic encephalopathy 108.25 10.39 93 408843 2606 90216905
Neoplasm progression 108.19 10.39 33 408903 44453 90175058
Thrombosis 106.33 10.39 104 408832 73147 90146364
Retinitis 105.97 10.39 398 408538 38060 90181451
Blood pressure increased 105.92 10.39 493 408443 196724 90022787
Skin exfoliation 105.01 10.39 91 408845 67822 90151689
Drug withdrawal syndrome 104.36 10.39 326 408610 28397 90191114
Temperature regulation disorder 104.25 10.39 214 408722 14365 90205146
Mental disorder 104.07 10.39 352 408584 31966 90187545
Torsade de pointes 104.05 10.39 219 408717 14963 90204548
White blood cell count decreased 103.80 10.39 395 408541 166714 90052797
Therapeutic product effect incomplete 103.37 10.39 486 408450 193410 90026101
Impulse-control disorder 100.78 10.39 60 408876 922 90218589
Oropharyngeal pain 100.72 10.39 232 408704 114955 90104556
Osteonecrosis of jaw 100.68 10.39 26 408910 39077 90180434
Memory impairment 99.40 10.39 1342 407594 195902 90023609
Inappropriate schedule of product administration 98.66 10.39 346 408590 149587 90069924
Blood cholesterol increased 98.64 10.39 1400 407536 206612 90012899
Feeling of despair 98.32 10.39 95 408841 3109 90216402
Hypotension 98.24 10.39 2036 406900 323361 89896150
Myoglobin urine present 98.16 10.39 54 408882 708 90218803
Productive cough 98.01 10.39 122 408814 76941 90142570
Hypotonia 96.63 10.39 180 408756 11246 90208265
Procedural pain 96.47 10.39 17 408919 33343 90186168
Bone marrow failure 96.34 10.39 15 408921 32206 90187305
Rheumatoid factor positive 96.22 10.39 1191 407745 170459 90049052
Renal failure 95.43 10.39 289 408647 130718 90088793
Injection site bruising 95.26 10.39 59 408877 52248 90167263
Drug withdrawal syndrome neonatal 95.24 10.39 81 408855 2238 90217273
Rheumatic fever 94.88 10.39 1083 407853 152038 90067473
Mood altered 93.68 10.39 226 408710 16918 90202593
Cytokine release syndrome 93.47 10.39 9 408927 27964 90191547
Depression 93.09 10.39 1888 407048 298713 89920798
Basal cell carcinoma 92.34 10.39 19 408917 33370 90186141
Drug hypersensitivity 92.09 10.39 1504 407432 462105 89757406
Dehydration 91.95 10.39 508 408428 193939 90025572
Hypotonia neonatal 91.60 10.39 65 408871 1365 90218146
Chronic sinusitis 90.25 10.39 4 408932 23798 90195713
Throat irritation 89.97 10.39 54 408882 48641 90170870
Jaundice cholestatic 89.71 10.39 162 408774 9881 90209630
Ascites 89.54 10.39 52 408884 47688 90171823
Palmar-plantar erythrodysaesthesia syndrome 88.60 10.39 11 408925 28012 90191499
Sinus disorder 88.51 10.39 23 408913 34424 90185087
Bronchitis 88.32 10.39 372 408564 152555 90066956
Cerebrovascular accident 88.21 10.39 275 408661 123258 90096253
Bipolar I disorder 88.13 10.39 74 408862 2008 90217503
Joint range of motion decreased 87.95 10.39 968 407968 134675 90084836
Wound infection 87.69 10.39 798 408138 105604 90113907
Food allergy 86.94 10.39 283 408653 25195 90194316
Onychomycosis 86.87 10.39 30 408906 37346 90182165
Diverticulitis 86.50 10.39 48 408888 45139 90174372
Stupor 86.46 10.39 115 408821 5367 90214144
Aspiration 84.81 10.39 206 408730 15487 90204024
Cataract 84.68 10.39 121 408815 71971 90147540
Pneumocystis jirovecii pneumonia 84.10 10.39 3 408933 21613 90197898
Surgery 84.03 10.39 49 408887 44838 90174673
Full blood count decreased 83.98 10.39 16 408920 29673 90189838
Dissociation 83.88 10.39 126 408810 6589 90212922
Cytomegalovirus infection 82.76 10.39 11 408925 26591 90192920
Haematochezia 81.36 10.39 121 408815 70792 90148719
Pneumonia aspiration 81.04 10.39 383 408553 40557 90178954
Apraxia 80.83 10.39 73 408863 2189 90217322
Drooling 80.52 10.39 101 408835 4445 90215066
Gastric pH decreased 80.30 10.39 52 408884 934 90218577
Pain in jaw 79.55 10.39 60 408876 47925 90171586
Sleep-related eating disorder 79.44 10.39 52 408884 952 90218559
Respiratory tract infection 78.89 10.39 90 408846 58988 90160523
Metastases to bone 78.27 10.39 11 408925 25494 90194017
Immunodeficiency 78.09 10.39 394 408542 42840 90176671
Eczema 77.97 10.39 74 408862 52796 90166715
Anaphylactic shock 77.71 10.39 23 408913 31594 90187917
Therapy interrupted 77.64 10.39 67 408869 50041 90169470
Abdominal pain 77.16 10.39 1288 407648 394433 89825078
Dysphonia 76.99 10.39 103 408833 62981 90156530
Psychomotor skills impaired 76.77 10.39 79 408857 2793 90216718
Somnambulism 76.57 10.39 116 408820 6112 90213399
Mood swings 76.16 10.39 236 408700 20466 90199045
Psychiatric decompensation 76.00 10.39 66 408870 1877 90217634
Finger deformity 75.44 10.39 27 408909 32870 90186641
Infarction 75.39 10.39 80 408856 2933 90216578
Hypokinesia 75.37 10.39 197 408739 15500 90204011
Peripheral swelling 75.28 10.39 1361 407575 411745 89807766
Long QT syndrome 75.22 10.39 92 408844 3945 90215566
Drug use disorder 75.06 10.39 135 408801 8208 90211303
Nightmare 74.75 10.39 242 408694 21483 90198028
Electrocardiogram QRS complex shortened 73.54 10.39 40 408896 512 90218999
Abdominal distension 73.38 10.39 321 408615 130280 90089231
Polydipsia 73.35 10.39 93 408843 4138 90215373
Nephrolithiasis 73.22 10.39 68 408868 49017 90170494
Sinus congestion 73.01 10.39 17 408919 27407 90192104
Head titubation 72.94 10.39 54 408882 1214 90218297
Viral infection 72.30 10.39 49 408887 41365 90178146
Pneumonitis 72.24 10.39 56 408880 44114 90175397
Asthenia 71.60 10.39 1847 407089 531904 89687607
Sinusitis 71.09 10.39 1104 407832 341984 89877527
Hypervolaemia 69.98 10.39 30 408906 32727 90186784
Localised infection 69.71 10.39 32 408904 33530 90185981
Apathy 69.64 10.39 154 408782 10886 90208625
Mental impairment 69.48 10.39 199 408737 16521 90202990
Death 69.15 10.39 1551 407385 455000 89764511
Coma blister 69.04 10.39 26 408910 127 90219384
Fibromyalgia 69.02 10.39 1311 407625 204958 90014553
Amenorrhoea 68.91 10.39 159 408777 11563 90207948
Cardiac failure 68.51 10.39 258 408678 109238 90110273
Sympathomimetic effect 68.22 10.39 26 408910 132 90219379
Anger 67.74 10.39 174 408762 13546 90205965
Drug screen positive 67.39 10.39 84 408852 3673 90215838
Hyperthermia 67.27 10.39 146 408790 10189 90209322
Suicidal behaviour 66.75 10.39 73 408863 2771 90216740
X-ray abnormal 66.54 10.39 391 408545 45033 90174478
Renal impairment 66.22 10.39 248 408688 105173 90114338
Cystitis 66.22 10.39 125 408811 66593 90152918
Respiratory disorder neonatal 66.02 10.39 53 408883 1348 90218163
Drug dependence 66.01 10.39 285 408651 29042 90190469
Sciatica 65.94 10.39 724 408212 100658 90118853
Angioedema 65.76 10.39 120 408816 64756 90154755
Psychotic symptom 65.69 10.39 65 408871 2191 90217320
Pleural effusion 65.54 10.39 271 408665 111720 90107791
Hypercalcaemia 64.63 10.39 37 408899 34203 90185308
Female genital tract fistula 64.62 10.39 4 408932 17864 90201647
Walking aid user 64.42 10.39 324 408612 35182 90184329
Injection site rash 64.33 10.39 15 408921 24158 90195353
Peripheral venous disease 63.94 10.39 619 408317 83302 90136209
Pulmonary hypertension 63.32 10.39 59 408877 42464 90177047
Posture abnormal 62.61 10.39 69 408867 2642 90216869
Blood calcium decreased 62.35 10.39 29 408907 30153 90189358
Angina pectoris 62.34 10.39 51 408885 39109 90180402
Behaviour disorder 62.26 10.39 90 408846 4545 90214966
Metastases to liver 62.16 10.39 26 408910 28781 90190730
Respiratory tract congestion 62.00 10.39 23 408913 27387 90192124
Myocarditis 61.97 10.39 169 408767 13637 90205874
Femur fracture 61.75 10.39 70 408866 46012 90173499
Tenderness 61.70 10.39 22 408914 26846 90192665
Lip dry 61.60 10.39 712 408224 100243 90119268
Onychomadesis 61.49 10.39 70 408866 45928 90173583
Self-injurious ideation 61.31 10.39 74 408862 3129 90216382
Tubulointerstitial nephritis 61.26 10.39 19 408917 25324 90194187
Hyperhidrosis 61.25 10.39 909 408027 135396 90084115
Hot flush 61.22 10.39 109 408827 59379 90160132
Osmolar gap increased 61.22 10.39 25 408911 157 90219354
Dysgeusia 60.96 10.39 89 408847 52471 90167040
Acute myeloid leukaemia 60.83 10.39 10 408926 20630 90198881
Oral candidiasis 60.50 10.39 43 408893 35412 90184099
Osteomyelitis 60.30 10.39 25 408911 27821 90191690
Fungal infection 60.28 10.39 62 408874 42599 90176912
Toxic encephalopathy 60.21 10.39 126 408810 8573 90210938
Mouth ulceration 60.07 10.39 55 408881 39919 90179592
Neutropenia 59.93 10.39 687 408249 224217 89995294
Oromandibular dystonia 59.70 10.39 36 408900 567 90218944
Myelodysplastic syndrome 59.69 10.39 11 408925 20892 90198619
Septic shock 59.62 10.39 188 408748 83972 90135539
Alcohol interaction 59.54 10.39 55 408881 1699 90217812
Oral pain 59.33 10.39 37 408899 32646 90186865
Accidental overdose 59.28 10.39 269 408667 28004 90191507
Logorrhoea 58.85 10.39 67 408869 2660 90216851
Depressive symptom 58.79 10.39 94 408842 5191 90214320
Incorrect route of product administration 58.29 10.39 410 408526 50216 90169295
Wheezing 58.13 10.39 1446 407490 236634 89982877
Medication error 58.06 10.39 611 408325 84041 90135470
Neoplasm malignant 57.93 10.39 41 408895 33839 90185672
Full blood count abnormal 57.84 10.39 48 408888 36549 90182962
Accidental poisoning 57.75 10.39 42 408894 918 90218593
Osteonecrosis 57.73 10.39 23 408913 26218 90193293
Nasopharyngitis 57.72 10.39 1397 407539 405707 89813804
Joint swelling 57.19 10.39 1782 407154 501518 89717993
Injection site urticaria 57.11 10.39 7 408929 18004 90201507
Dry eye 57.08 10.39 109 408827 57822 90161689
Bone density decreased 56.86 10.39 6 408930 17339 90202172
Tooth infection 56.78 10.39 11 408925 20159 90199352
Injury 56.63 10.39 1226 407710 196123 90023388
Muscle injury 56.45 10.39 1115 407821 175539 90043972
Pulmonary arterial hypertension 55.92 10.39 24 408912 26163 90193348
Asthma-chronic obstructive pulmonary disease overlap syndrome 55.68 10.39 88 408848 4811 90214700
Neutropenic sepsis 55.21 10.39 8 408928 18122 90201389
Bone disorder 54.70 10.39 18 408918 23102 90196409
Swelling face 54.67 10.39 186 408750 81166 90138345
Candida infection 54.66 10.39 44 408892 34013 90185498
Clostridium difficile colitis 54.64 10.39 26 408910 26680 90192831
Total lung capacity increased 54.07 10.39 88 408848 4933 90214578
Circulatory collapse 53.75 10.39 239 408697 24665 90194846
Gastric disorder 53.74 10.39 43 408893 33341 90186170
Rheumatoid arthritis 53.71 10.39 2072 406864 360542 89858969
Hypertonia 53.69 10.39 89 408847 5066 90214445
Tenosynovitis 53.47 10.39 3 408933 14564 90204947
Exposure via ingestion 53.33 10.39 63 408873 2604 90216907
Coronary artery disease 53.27 10.39 44 408892 33579 90185932
Red blood cell count decreased 53.25 10.39 79 408857 46272 90173239
Hypercholesterolaemia 53.09 10.39 692 408244 100200 90119311
Blood pressure systolic increased 53.05 10.39 115 408821 58230 90161281
Personality change due to a general medical condition 53.03 10.39 26 408910 264 90219247
Panniculitis 53.00 10.39 3 408933 14455 90205056
Burning sensation 52.91 10.39 131 408805 63321 90156190
Thermal burn 52.83 10.39 103 408833 6659 90212852
Drug intolerance 52.74 10.39 1577 407359 446014 89773497
Psychiatric symptom 52.69 10.39 106 408830 7012 90212499
Lymphadenopathy 52.61 10.39 78 408858 45697 90173814
Constipation 52.55 10.39 919 408017 279476 89940035
Wound 52.15 10.39 1761 407175 301219 89918292
Borderline personality disorder 52.01 10.39 41 408895 1015 90218496
Neutrophil count decreased 51.94 10.39 158 408778 71374 90148137
Labelled drug-drug interaction issue 51.33 10.39 57 408879 2201 90217310
Hypersexuality 50.94 10.39 33 408903 593 90218918
Gastrointestinal disorder 50.79 10.39 833 408103 255854 89963657
Proctitis 50.74 10.39 5 408931 15254 90204257
Device difficult to use 50.52 10.39 9 408927 17516 90201995
Skin necrosis 50.39 10.39 8 408928 16933 90202578
Cytopenia 50.22 10.39 9 408927 17440 90202071
Potentiating drug interaction 50.15 10.39 91 408845 5571 90213940
Flatulence 50.01 10.39 68 408868 41299 90178212
Pemphigus 49.90 10.39 1874 407062 324990 89894521
Refusal of examination 49.88 10.39 23 408913 201 90219310
H1N1 influenza 49.64 10.39 53 408883 1957 90217554
Eye irritation 49.59 10.39 48 408888 33930 90185581
Illness 49.44 10.39 196 408740 81773 90137738
Tachyphrenia 49.39 10.39 49 408887 1657 90217854
Euphoric mood 49.27 10.39 88 408848 5321 90214190
Lupus-like syndrome 49.07 10.39 383 408553 48463 90171048
Urinary hesitation 48.95 10.39 58 408878 2405 90217106
Generalised tonic-clonic seizure 48.92 10.39 297 408639 34606 90184905
Impulsive behaviour 48.82 10.39 49 408887 1681 90217830
Eosinophil count decreased 48.55 10.39 66 408870 3146 90216365
Schizoaffective disorder 48.51 10.39 85 408851 5062 90214449
Weight decreased 48.42 10.39 1324 407612 378586 89840925
Urine osmolarity increased 48.39 10.39 19 408917 106 90219405
Therapeutic product effect decreased 48.17 10.39 922 408014 276649 89942862
Postural tremor 48.07 10.39 29 408907 457 90219054
Haematuria 47.98 10.39 52 408884 34885 90184626
Haemorrhage 47.71 10.39 157 408779 69212 90150299
Rash pruritic 47.44 10.39 200 408736 82014 90137497
Haemorrhoids 47.41 10.39 31 408905 26671 90192840
Pulmonary oedema 47.34 10.39 134 408802 61946 90157565
Lacrimation increased 47.27 10.39 32 408904 27030 90192481
Eye pruritus 47.22 10.39 37 408899 28990 90190521
Paraesthesia oral 47.05 10.39 44 408892 31615 90187896
Antipsychotic drug level below therapeutic 47.01 10.39 25 408911 305 90219206
Arthritis 46.97 10.39 505 408431 166810 90052701
Bacteraemia 46.73 10.39 21 408915 22279 90197232
Pancreatitis 46.48 10.39 501 408435 69325 90150186
Metastases to central nervous system 46.45 10.39 11 408925 17531 90201980
Ulcer 46.22 10.39 48 408888 32834 90186677
Mutism 46.10 10.39 48 408888 1721 90217790
Unevaluable event 45.92 10.39 113 408823 54735 90164776
Tension 45.86 10.39 69 408867 3613 90215898
Skin disorder 45.74 10.39 59 408877 36647 90182864
Atrial septal defect 45.48 10.39 109 408827 8125 90211386
Clonus 45.43 10.39 88 408848 5662 90213849
Pericarditis 45.43 10.39 1566 407370 268585 89950926
Hypothermia 45.26 10.39 164 408772 15411 90204100
Haematotoxicity 44.75 10.39 3 408933 12532 90206979
Chronic kidney disease 44.75 10.39 100 408836 50091 90169420
Adverse reaction 44.50 10.39 41 408895 29671 90189840
Clostridium difficile infection 44.41 10.39 59 408877 36186 90183325
Breast cancer stage III 44.34 10.39 579 408357 83868 90135643
Major depression 44.21 10.39 122 408814 9913 90209598
Uveitis 44.08 10.39 9 408927 15894 90203617
Drug level increased 43.96 10.39 244 408692 27518 90191993
Affective disorder 43.95 10.39 104 408832 7689 90211822
Psychotic behaviour 43.93 10.39 31 408905 645 90218866
Muscle spasticity 43.78 10.39 57 408879 35265 90184246
Pyrexia 43.76 10.39 2486 406450 657999 89561512
Oral herpes 43.75 10.39 52 408884 33472 90186039
Rabbit syndrome 43.54 10.39 24 408912 316 90219195
Ulcer haemorrhage 43.47 10.39 234 408702 26087 90193424
Tendonitis 43.43 10.39 21 408915 21351 90198160
Gangrene 43.40 10.39 4 408932 12872 90206639
Cardiac disorder 43.19 10.39 123 408813 56749 90162762
Device related infection 43.05 10.39 32 408904 25754 90193757
Porphyria acute 43.03 10.39 178 408758 17797 90201714
Parkinsonian gait 42.83 10.39 29 408907 563 90218948
Aspartate aminotransferase increased 42.80 10.39 280 408656 102657 90116854
Radiculopathy 42.75 10.39 15 408921 18490 90201021
Self-destructive behaviour 42.73 10.39 27 408909 464 90219047
Sneezing 42.66 10.39 43 408893 29826 90189685
Gastritis 42.52 10.39 77 408859 41676 90177835
Product storage error 42.51 10.39 19 408917 20222 90199289
Anti-cyclic citrullinated peptide antibody 42.28 10.39 238 408698 26983 90192528
Hypoacusis 42.23 10.39 38 408898 27812 90191699
Abnormal weight gain 42.18 10.39 56 408880 2609 90216902
Nephrogenic diabetes insipidus 42.14 10.39 35 408901 935 90218576
Lymphocyte count decreased 41.99 10.39 58 408878 34992 90184519
Skin haemorrhage 41.96 10.39 22 408914 21358 90198153
Musculoskeletal disorder 41.84 10.39 23 408913 21746 90197765
Seasonal allergy 41.74 10.39 26 408910 22957 90196554
Acute psychosis 41.69 10.39 60 408876 3018 90216493
Subcutaneous drug absorption impaired 41.40 10.39 145 408791 13400 90206111
Bundle branch block right 41.32 10.39 82 408854 5371 90214140
Product label confusion 41.29 10.39 26 408910 22824 90196687
Gastrooesophageal reflux disease 41.27 10.39 516 408420 165821 90053690
Panic attack 41.27 10.39 231 408705 26134 90193377
Embolism venous 41.11 10.39 65 408871 3555 90215956
Bronchospasm 41.10 10.39 21 408915 20688 90198823
Bursitis 41.05 10.39 828 408108 130826 90088685
Disseminated intravascular coagulation 41.05 10.39 23 408913 21515 90197996
Seronegative arthritis 40.88 10.39 177 408759 18057 90201454
Substance use disorder 40.86 10.39 48 408888 1972 90217539
Carpal tunnel syndrome 40.85 10.39 29 408907 23899 90195612
Skin lesion 40.71 10.39 66 408870 37299 90182212
Transfusion 40.71 10.39 14 408922 17474 90202037
Hip arthroplasty 40.63 10.39 524 408412 75684 90143827
Right ventricular failure 40.37 10.39 18 408918 19187 90200324
Menstrual disorder 40.28 10.39 87 408849 6051 90213460
Deafness 40.16 10.39 26 408910 22488 90197023
Gout 40.11 10.39 13 408923 16846 90202665
Breast cancer female 40.08 10.39 9 408927 14877 90204634
Small for dates baby 40.01 10.39 77 408859 4930 90214581
Bronchopulmonary aspergillosis 39.91 10.39 3 408933 11395 90208116
Tic 39.64 10.39 46 408890 1865 90217646
Malignant melanoma 39.60 10.39 5 408931 12571 90206940
Maternal exposure during pregnancy 39.49 10.39 1995 406941 358068 89861443
Rash maculo-papular 39.48 10.39 78 408858 40855 90178656
Homicide 39.43 10.39 22 408914 297 90219214
Hyperkalaemia 39.39 10.39 155 408781 64809 90154702
Dermatitis 39.18 10.39 26 408910 22194 90197317
Breast cancer metastatic 39.07 10.39 10 408926 15122 90204389
Disability 39.02 10.39 316 408620 40429 90179082
Depressed mood 39.02 10.39 372 408564 49850 90169661
Intervertebral disc protrusion 39.02 10.39 39 408897 27157 90192354
Alcohol abuse 38.97 10.39 47 408889 1986 90217525
Accidental exposure to product 38.93 10.39 83 408853 42283 90177228
Gynaecomastia 38.86 10.39 20 408916 227 90219284
Spinal fracture 38.50 10.39 26 408910 21990 90197521
Laryngitis 38.48 10.39 374 408562 50379 90169132
Metastases to lymph nodes 38.43 10.39 4 408932 11685 90207826
Enuresis 38.36 10.39 61 408875 3353 90216158
Multiple sclerosis relapse 38.35 10.39 115 408821 52190 90167321
Joint injury 38.18 10.39 55 408881 32609 90186902
Dementia 37.97 10.39 210 408726 23651 90195860
Off label use 37.88 10.39 4376 404560 1097876 89121635
Aplastic anaemia 37.85 10.39 7 408929 13262 90206249
Hyperkinesia 37.82 10.39 45 408891 1874 90217637
Osteopenia 37.82 10.39 29 408907 22973 90196538
Musculoskeletal discomfort 37.77 10.39 24 408912 20967 90198544
Thrombotic microangiopathy 37.70 10.39 12 408924 15731 90203780
Tooth disorder 37.69 10.39 51 408885 31039 90188472
Meconium aspiration syndrome 37.51 10.39 11 408925 19 90219492
Product dose omission in error 37.51 10.39 23 408913 20480 90199031
Schizophreniform disorder 37.44 10.39 15 408921 89 90219422
C-reactive protein 37.26 10.39 256 408680 31111 90188400
Pneumothorax 37.21 10.39 20 408916 19147 90200364
Right ventricular false tendon 37.17 10.39 10 408926 10 90219501
Spinal stenosis 37.15 10.39 16 408920 17408 90202103
Haematoma 37.15 10.39 75 408861 38973 90180538
Palpitations 37.05 10.39 416 408520 136312 90083199
Electrocardiogram repolarisation abnormality 37.05 10.39 38 408898 1338 90218173
Conversion disorder 36.93 10.39 47 408889 2099 90217412
Device dislocation 36.81 10.39 53 408883 31429 90188082
Influenza like illness 36.78 10.39 213 408723 80398 90139113
Amimia 36.75 10.39 14 408922 71 90219440
Negativism 36.68 10.39 24 408912 439 90219072
Tonic clonic movements 36.64 10.39 42 408894 1680 90217831
Conjunctival abrasion 36.48 10.39 11 408925 22 90219489
Lip swelling 36.02 10.39 75 408861 38535 90180976
Injection site warmth 35.91 10.39 17 408919 17498 90202013
Neonatal disorder 35.84 10.39 26 408910 566 90218945
Upper limb fracture 35.74 10.39 27 408909 21551 90197960
Burning mouth syndrome 35.41 10.39 26 408910 577 90218934
Hospitalisation 35.41 10.39 388 408548 127712 90091799
Feeling abnormal 35.32 10.39 536 408400 166699 90052812
Skin reaction 35.09 10.39 20 408916 18533 90200978
Atrioventricular block first degree 35.07 10.39 101 408835 8410 90211101
Cognitive disorder 34.83 10.39 472 408464 68935 90150576
No adverse event 34.69 10.39 173 408763 67809 90151702
Stereotypy 34.58 10.39 23 408913 433 90219078
Withdrawal catatonia 34.56 10.39 17 408919 174 90219337
Squamous cell carcinoma 34.42 10.39 3 408933 10098 90209413
Self-medication 34.09 10.39 56 408880 3164 90216347
Joint dislocation 34.03 10.39 329 408607 44253 90175258
Progressive multifocal leukoencephalopathy 33.98 10.39 14 408922 15641 90203870
Malignant catatonia 33.96 10.39 18 408918 218 90219293
Faecaloma 33.92 10.39 114 408822 10317 90209194
Atelectasis 33.89 10.39 36 408900 24373 90195138
Herbal interaction 33.83 10.39 16 408920 149 90219362
Infantile apnoea 33.68 10.39 35 408901 1252 90218259
Apnoea 33.42 10.39 106 408830 9308 90210203
Gastric ulcer 33.30 10.39 45 408891 27403 90192108
Diverticulum 33.27 10.39 7 408929 12106 90207405
Congenital vesicoureteric reflux 33.16 10.39 10 408926 20 90219491
Alcohol poisoning 33.10 10.39 42 408894 1870 90217641
Blood iron decreased 33.06 10.39 20 408916 17939 90201572
Tuberculosis 32.97 10.39 8 408928 12541 90206970
Joint destruction 32.93 10.39 133 408803 13154 90206357
Hypersensitivity 32.93 10.39 1696 407240 452981 89766530
Grip strength 32.79 10.39 102 408834 8863 90210648
Complication associated with device 32.65 10.39 24 408912 19425 90200086
Post procedural complication 32.61 10.39 23 408913 19019 90200492
Product use issue 32.55 10.39 1810 407126 328109 89891402
Feeling of body temperature change 32.52 10.39 76 408860 5573 90213938
Hypomagnesaemia 32.47 10.39 70 408866 35518 90183993
Peripartum cardiomyopathy 32.43 10.39 17 408919 201 90219310
Food interaction 32.40 10.39 34 408902 1230 90218281
Accidental death 32.36 10.39 43 408893 2005 90217506
Emotional poverty 32.15 10.39 21 408915 383 90219128
Skin discolouration 32.08 10.39 98 408838 44217 90175294
Vasculitis 32.04 10.39 33 408903 22660 90196851
Skin fissures 32.02 10.39 28 408908 20781 90198730
Injection site haemorrhage 31.82 10.39 49 408887 28269 90191242
Duodenal ulcer perforation 31.68 10.39 1260 407676 220028 89999483
Ataxia 31.58 10.39 163 408773 17879 90201632
Gait inability 31.52 10.39 875 408061 145581 90073930
Somatic symptom disorder 31.37 10.39 56 408880 3385 90216126
Blood osmolarity increased 31.33 10.39 20 408916 350 90219161
Amniotic fluid volume increased 31.21 10.39 16 408920 180 90219331
Exostosis 31.19 10.39 372 408564 52762 90166749
General physical health deterioration 31.18 10.39 1928 407008 353187 89866324
Pseudomonas infection 31.14 10.39 14 408922 14851 90204660
Hypertonia neonatal 31.14 10.39 18 408918 261 90219250
Total lung capacity decreased 31.11 10.39 59 408877 3736 90215775
Intestinal pseudo-obstruction 31.10 10.39 32 408904 1131 90218380
Respiratory syncytial virus infection 31.06 10.39 5 408931 10475 90209036
Neonatal hypoxia 30.98 10.39 26 408910 705 90218806
Posterior reversible encephalopathy syndrome 30.96 10.39 33 408903 22306 90197205
Wrong patient received product 30.95 10.39 56 408880 3421 90216090
Renal papillary necrosis 30.84 10.39 18 408918 266 90219245
Electrocardiogram T wave biphasic 30.84 10.39 7 408929 0 90219511
Antidepressant drug level above therapeutic 30.76 10.39 22 408914 468 90219043
Spinal compression fracture 30.71 10.39 15 408921 15163 90204348
Tremor neonatal 30.71 10.39 15 408921 151 90219360
Anaemia of pregnancy 30.62 10.39 15 408921 152 90219359
Multiple allergies 30.60 10.39 15 408921 15131 90204380
Adjustment disorder with mixed anxiety and depressed mood 30.50 10.39 14 408922 121 90219390
Ventricular fibrillation 30.48 10.39 135 408801 13909 90205602
Action tremor 30.35 10.39 19 408917 321 90219190
Night sweats 30.20 10.39 778 408158 127988 90091523
Drug dose omission by device 30.05 10.39 5 408931 10226 90209285
Hyperthermia malignant 29.91 10.39 33 408903 1265 90218246
Hyperphagia 29.82 10.39 49 408887 2769 90216742
Hemiplegia 29.74 10.39 18 408918 16142 90203369
Rectal atresia 29.74 10.39 8 408928 8 90219503
Sirenomelia 29.74 10.39 8 408928 8 90219503
Cyst 29.71 10.39 19 408917 16542 90202969
Slow speech 29.64 10.39 40 408896 1893 90217618
Hepatitis 29.62 10.39 192 408744 70547 90148964
Creatinine renal clearance decreased 29.61 10.39 25 408911 18874 90200637
Ocular hyperaemia 29.59 10.39 68 408868 33730 90185781
Excessive masturbation 29.52 10.39 9 408927 19 90219492
Blood potassium decreased 29.49 10.39 113 408823 47614 90171897
Ageusia 29.46 10.39 18 408918 16058 90203453
Drug tolerance 29.40 10.39 159 408777 17757 90201754
On and off phenomenon 29.35 10.39 46 408890 2497 90217014
Hypocholesterolaemia 29.00 10.39 79 408857 6370 90213141
Congenital thrombocytopenia 29.00 10.39 11 408925 55 90219456
Bronchopulmonary aspergillosis allergic 28.98 10.39 57 408879 3709 90215802
Ejection fraction decreased 28.95 10.39 46 408890 26207 90193304
Post procedural haemorrhage 28.95 10.39 3 408933 8795 90210716
Rotator cuff syndrome 28.92 10.39 18 408918 15901 90203610
Hyperammonaemia 28.80 10.39 79 408857 6396 90213115
Skin infection 28.77 10.39 23 408913 17841 90201670
Colon cancer 28.71 10.39 7 408929 10937 90208574
Protein C increased 28.68 10.39 11 408925 57 90219454
Cushingoid 28.57 10.39 6 408930 10389 90209122
Therapeutic product ineffective 28.32 10.39 44 408892 2370 90217141
Diffuse large B-cell lymphoma 28.31 10.39 3 408933 8642 90210869
Transient ischaemic attack 28.14 10.39 100 408836 43076 90176435
Congenital hand malformation 28.10 10.39 18 408918 317 90219194
Thrombocytopenia 27.98 10.39 722 408214 208003 90011508
Respiratory rate decreased 27.93 10.39 58 408878 3925 90215586
Developmental hip dysplasia 27.73 10.39 35 408901 1550 90217961
Tricuspid valve incompetence 27.63 10.39 21 408915 16710 90202801
Adverse drug reaction 27.63 10.39 706 408230 115995 90103516
Antidepressant drug level increased 27.62 10.39 19 408917 379 90219132
Homicidal ideation 27.55 10.39 37 408899 1743 90217768
Infusion site pain 27.53 10.39 29 408907 19709 90199802
Therapy cessation 27.34 10.39 79 408857 36282 90183229
Stoma site discharge 27.27 10.39 39 408897 1950 90217561
Alcoholism 27.23 10.39 37 408899 1763 90217748
Lymphoedema 27.21 10.39 14 408922 13739 90205772
Hyporesponsive to stimuli 27.18 10.39 35 408901 1582 90217929
Drug screen false positive 27.15 10.39 27 408909 916 90218595
Anti-cyclic citrullinated peptide antibody positive 27.14 10.39 1316 407620 235117 89984394
Neuralgia 27.08 10.39 64 408872 31436 90188075
Inappropriate affect 27.05 10.39 28 408908 997 90218514
Acute generalised exanthematous pustulosis 27.04 10.39 14 408922 13689 90205822
Device issue 27.03 10.39 58 408878 29479 90190032
Blood magnesium decreased 26.82 10.39 19 408917 15674 90203837
Cerebellar atrophy 26.81 10.39 25 408911 782 90218729
Eye swelling 26.65 10.39 58 408878 29328 90190183
Pneumonia viral 26.62 10.39 4 408932 8819 90210692
Ankylosing spondylitis 26.54 10.39 13 408923 13120 90206391
Conjunctivitis 26.53 10.39 50 408886 26656 90192855
Fall 26.39 10.39 1845 407091 479965 89739546
Hypersomnia 26.34 10.39 177 408759 21354 90198157
Corneal reflex decreased 26.32 10.39 17 408919 304 90219207
Heart rate decreased 26.26 10.39 138 408798 53367 90166144
Gastroenteritis 26.25 10.39 58 408878 29171 90190340
Graft versus host disease 26.23 10.39 3 408933 8141 90211370
Neonatal respiratory distress 26.14 10.39 23 408913 666 90218845
Peripheral sensory neuropathy 26.13 10.39 5 408931 9245 90210266
Ventricular septal defect 26.10 10.39 68 408868 5339 90214172
Troponin increased 26.10 10.39 124 408812 13157 90206354
Abscess 26.07 10.39 28 408908 18863 90200648
Eye infection 26.06 10.39 16 408920 14238 90205273
Blunted affect 26.04 10.39 16 408920 261 90219250
Back injury 25.93 10.39 115 408821 46507 90173004
Hepatic enzyme increased 25.91 10.39 1926 407010 358810 89860701
Bipolar II disorder 25.90 10.39 19 408917 421 90219090
Pressure of speech 25.86 10.39 24 408912 746 90218765
Device malfunction 25.85 10.39 34 408902 20943 90198568
Social anxiety disorder 25.77 10.39 22 408914 611 90218900
Nuchal rigidity 25.75 10.39 24 408912 750 90218761
Blood urine present 25.69 10.39 24 408912 17254 90202257
Nerve injury 25.66 10.39 9 408927 11097 90208414
Vaginal discharge 25.61 10.39 30 408906 19434 90200077
Arthritis infective 25.60 10.39 3 408933 7989 90211522
Pulmonary toxicity 25.54 10.39 10 408926 11521 90207990
Floppy iris syndrome 25.53 10.39 12 408924 110 90219401
Proteinuria 25.51 10.39 41 408895 23250 90196261
Carotid artery thrombosis 25.50 10.39 5 408931 9087 90210424
Slow response to stimuli 25.49 10.39 28 408908 1068 90218443
Schizoaffective disorder bipolar type 25.49 10.39 14 408922 183 90219328
Toothache 25.43 10.39 38 408898 22192 90197319
Glossodynia 25.34 10.39 1731 407205 320048 89899463
Feelings of worthlessness 25.28 10.39 18 408918 380 90219131
Helicobacter infection 25.27 10.39 1259 407677 225591 89993920
Akinesia 25.23 10.39 35 408901 1701 90217810
Diabetes insipidus 25.18 10.39 49 408887 3163 90216348
Enterocolitis 25.11 10.39 8 408928 10482 90209029
Impaired quality of life 25.10 10.39 41 408895 23103 90196408
Upper-airway cough syndrome 24.99 10.39 19 408917 15116 90204395
Nephropathy toxic 24.98 10.39 13 408923 12675 90206836
Antisocial behaviour 24.97 10.39 21 408915 571 90218940
Rash vesicular 24.97 10.39 154 408782 18043 90201468
Faeces discoloured 24.82 10.39 36 408900 21284 90198227
Pancreatic carcinoma 24.82 10.39 4 408932 8373 90211138
Anion gap increased 24.74 10.39 40 408896 2230 90217281
PO2 increased 24.69 10.39 25 408911 867 90218644
Depressive delusion 24.67 10.39 7 408929 10 90219501
Postoperative wound infection 24.65 10.39 15 408921 13411 90206100
Abdominal pain lower 24.62 10.39 63 408873 30114 90189397
Blood triglycerides increased 24.56 10.39 125 408811 13636 90205875
Breath sounds abnormal 24.54 10.39 20 408916 15366 90204145
Amylase increased 24.53 10.39 79 408857 6993 90212518
Cerebral haemorrhage 24.53 10.39 77 408859 34445 90185066
Wrong dose 24.46 10.39 37 408899 1947 90217564
Screaming 24.44 10.39 53 408883 3697 90215814
Generalised oedema 24.39 10.39 30 408906 19023 90200488
Disinhibition 24.35 10.39 27 408909 1041 90218470
Post-traumatic stress disorder 24.34 10.39 77 408859 6751 90212760
Mitral valve incompetence 24.34 10.39 40 408896 22484 90197027
Pulmonary mass 24.30 10.39 59 408877 28713 90190798
Oxygen saturation decreased 24.25 10.39 340 408596 107143 90112368
Joint effusion 24.23 10.39 32 408904 19678 90199833
Job dissatisfaction 24.20 10.39 10 408926 65 90219446
Polyneuropathy 24.19 10.39 31 408905 19310 90200201
Eye disorder 24.07 10.39 55 408881 27335 90192176
Dry mouth 24.05 10.39 1038 407898 183021 90036490
Grip strength decreased 23.99 10.39 567 408369 92009 90127502
Urine sodium increased 23.97 10.39 11 408925 95 90219416
Acute myocardial infarction 23.97 10.39 79 408857 34811 90184700
Eye haemorrhage 23.95 10.39 8 408928 10172 90209339
Hepatic cirrhosis 23.94 10.39 410 408526 62843 90156668
Electrocardiogram abnormal 23.89 10.39 101 408835 10197 90209314
Illusion 23.87 10.39 29 408907 1235 90218276
Pathogen resistance 23.76 10.39 4 408932 8111 90211400
Drug eruption 23.75 10.39 81 408855 35326 90184185
Breast cancer stage II 23.73 10.39 254 408682 35080 90184431
Escherichia infection 23.73 10.39 22 408914 15873 90203638
Abulia 23.62 10.39 22 408914 687 90218824
Cortisol increased 23.54 10.39 19 408917 487 90219024
Musculoskeletal stiffness 23.49 10.39 1596 407340 294936 89924575
Intervertebral disc degeneration 23.40 10.39 26 408910 17248 90202263
Squamous cell carcinoma of skin 23.36 10.39 3 408933 7446 90212065
Rash macular 23.35 10.39 65 408871 30215 90189296
Victim of crime 23.33 10.39 24 408912 848 90218663
Dermatitis atopic 23.27 10.39 44 408892 23428 90196083
Eye injury 23.21 10.39 105 408831 10915 90208596
Congenital hearing disorder 23.21 10.39 7 408929 14 90219497
Emotional disorder 23.21 10.39 131 408805 14866 90204645
Adulterated product 23.16 10.39 17 408919 377 90219134
Sleep disorder 23.09 10.39 1104 407832 196926 90022585
Asterixis 23.05 10.39 33 408903 1652 90217859
Physical assault 23.01 10.39 24 408912 862 90218649
Dependence 22.94 10.39 37 408899 2058 90217453
Initial insomnia 22.92 10.39 93 408843 9217 90210294
Diastolic dysfunction 22.89 10.39 3 408933 7330 90212181
Product tampering 22.85 10.39 18 408918 445 90219066
Sense of a foreshortened future 22.82 10.39 6 408930 5 90219506
Self esteem decreased 22.82 10.39 23 408913 793 90218718
Kidney infection 22.80 10.39 52 408884 25864 90193647
Feeling guilty 22.78 10.39 21 408915 647 90218864
Chemical submission 22.77 10.39 19 408917 511 90219000
Attention deficit hyperactivity disorder 22.69 10.39 55 408881 4129 90215382
General symptom 22.62 10.39 128 408808 14540 90204971
Purpura 22.60 10.39 20 408916 14758 90204753
Hemiparesis 22.59 10.39 71 408865 31748 90187763
Drug ineffective for unapproved indication 22.58 10.39 192 408744 66452 90153059
Binge eating 22.56 10.39 20 408916 585 90218926
Arrhythmia 22.53 10.39 291 408645 42041 90177470
Pustular psoriasis 22.37 10.39 152 408784 18404 90201107
Aphthous ulcer 22.36 10.39 27 408909 17260 90202251
Foot deformity 22.34 10.39 386 408550 59265 90160246
Negative thoughts 22.08 10.39 26 408910 1071 90218440
Blood pressure fluctuation 22.07 10.39 142 408794 52271 90167240
Blood pressure abnormal 22.07 10.39 34 408902 19611 90199900
Staphylococcal parotitis 22.03 10.39 5 408931 0 90219511
Acute respiratory failure 22.02 10.39 109 408827 42809 90176702
Groin pain 21.93 10.39 14 408922 12199 90207312
Premature delivery 21.93 10.39 95 408841 38667 90180844
Gastrointestinal sounds abnormal 21.79 10.39 57 408879 4486 90215025
Synovial cyst 21.75 10.39 13 408923 11739 90207772
Kidney duplex 21.75 10.39 11 408925 120 90219391
Device stimulation issue 21.72 10.39 9 408927 59 90219452
Rib fracture 21.71 10.39 55 408881 26380 90193131
Central obesity 21.68 10.39 29 408907 1361 90218150
Immune thrombocytopenia 21.66 10.39 17 408919 13309 90206202
Cervix neoplasm 21.65 10.39 13 408923 203 90219308
Infusion site swelling 21.64 10.39 13 408923 11707 90207804
Immune reconstitution inflammatory syndrome 21.60 10.39 3 408933 7016 90212495
Muscle disorder 21.60 10.39 64 408872 5415 90214096
Live birth 21.58 10.39 488 408448 78619 90140892
Gallbladder disorder 21.56 10.39 35 408901 19768 90199743
Bacterial infection 21.48 10.39 46 408890 23398 90196113
Incoherent 21.42 10.39 60 408876 4917 90214594
Decreased bronchial secretion 21.34 10.39 9 408927 62 90219449
Rebound psychosis 21.27 10.39 13 408923 210 90219301
Loss of personal independence in daily activities 21.23 10.39 460 408476 135645 90083866
Status epilepticus 21.22 10.39 152 408784 18722 90200789
Pneumonia bacterial 21.19 10.39 16 408920 12774 90206737
International normalised ratio increased 21.06 10.39 126 408810 47190 90172321
Infective pulmonary exacerbation of cystic fibrosis 21.04 10.39 10 408926 10269 90209242
Neonatal behavioural syndrome 20.97 10.39 10 408926 95 90219416
Single umbilical artery 20.94 10.39 15 408921 320 90219191
COVID-19 pneumonia 20.86 10.39 31 408905 18146 90201365
Toxic epidermal necrolysis 20.76 10.39 76 408860 32452 90187059
Spinal osteoarthritis 20.69 10.39 34 408902 19114 90200397
Irritable bowel syndrome 20.61 10.39 1139 407797 206309 90013202
Foot fracture 20.60 10.39 57 408879 26549 90192962
CYP2C19 polymorphism 20.53 10.39 7 408929 24 90219487
Generalised anxiety disorder 20.44 10.39 41 408895 2706 90216805
Gingival pain 20.36 10.39 9 408927 9643 90209868
Discoloured vomit 20.35 10.39 26 408910 1166 90218345
Infusion site erythema 20.31 10.39 19 408917 13651 90205860
Device breakage 20.31 10.39 20 408916 14024 90205487
Liver function test abnormal 20.28 10.39 140 408796 50705 90168806
Pelvic kidney 20.27 10.39 10 408926 103 90219408
Alanine aminotransferase increased 20.22 10.39 394 408542 117944 90101567
Movement disorder 20.15 10.39 210 408726 28809 90190702
Sleep disorder due to general medical condition, insomnia type 20.12 10.39 740 408196 127954 90091557
Neuroglycopenia 20.11 10.39 25 408911 1090 90218421
Leukopenia 20.09 10.39 596 408340 100114 90119397
Perinatal depression 20.07 10.39 22 408914 837 90218674
Persistent genital arousal disorder 20.07 10.39 20 408916 680 90218831
Lymphoma 20.06 10.39 19 408917 13572 90205939
Inflammation 20.06 10.39 633 408303 177959 90041552
Hypovolaemia 20.02 10.39 16 408920 12415 90207096
Peripheral circulatory failure 19.90 10.39 30 408906 1574 90217937
Second primary malignancy 19.90 10.39 11 408925 10367 90209144
Nasal oedema 19.83 10.39 3 408933 6581 90212930
Hysterectomy 19.83 10.39 14 408922 11570 90207941
Electrocardiogram QT interval abnormal 19.81 10.39 13 408923 239 90219272
Social avoidant behaviour 19.74 10.39 46 408890 3367 90216144
Body height decreased 19.73 10.39 15 408921 11934 90207577
Granulocytopenia 19.73 10.39 69 408867 6372 90213139
Enteritis 19.70 10.39 11 408925 10310 90209201
SARS-CoV-2 test positive 19.65 10.39 13 408923 11115 90208396
Psychotic disorder due to a general medical condition 19.53 10.39 13 408923 245 90219266
Post procedural infection 19.47 10.39 13 408923 11061 90208450
Hypophosphataemia 19.43 10.39 23 408913 14831 90204680
Pulmonary haemorrhage 19.38 10.39 6 408930 8007 90211504
White blood cell count abnormal 19.30 10.39 5 408931 7499 90212012
Sluggishness 19.27 10.39 65 408871 5894 90213617
Incontinence 19.26 10.39 115 408821 13320 90206191
Melaena 19.25 10.39 86 408850 34711 90184800
Renal cyst 19.24 10.39 18 408918 12932 90206579
Peripheral vascular disorder 19.21 10.39 3 408933 6428 90213083
Vitamin D deficiency 19.14 10.39 31 408905 17525 90201986
Meconium in amniotic fluid 19.09 10.39 14 408922 310 90219201
Muscle atrophy 19.08 10.39 7 408929 8394 90211117
Crepitations 19.08 10.39 8 408928 8844 90210667
Arthritis bacterial 19.07 10.39 5 408931 7440 90212071
Regressive behaviour 19 10.39 12 408924 206 90219305
Ureterocele 18.98 10.39 6 408930 15 90219496
Pupillary disorder 18.95 10.39 13 408923 258 90219253
Dermatitis contact 18.93 10.39 20 408916 13575 90205936
Dermatitis acneiform 18.90 10.39 3 408933 6351 90213160
Wrong technique in product usage process 18.90 10.39 219 408717 71352 90148159
Immunosuppression 18.89 10.39 16 408920 12061 90207450
Pathological fracture 18.87 10.39 10 408926 9650 90209861
Morbid thoughts 18.83 10.39 20 408916 734 90218777
Aortic stenosis 18.83 10.39 3 408933 6333 90213178
Merycism 18.82 10.39 14 408922 317 90219194
Vitamin K decreased 18.79 10.39 7 408929 33 90219478
Sinus bradycardia 18.76 10.39 136 408800 16816 90202695
Bone erosion 18.75 10.39 340 408596 52681 90166830
Spasmodic dysphonia 18.74 10.39 9 408927 87 90219424
Substance use 18.68 10.39 25 408911 1174 90218337
Ligament sprain 18.67 10.39 23 408913 14576 90204935
Tongue spasm 18.65 10.39 9 408927 88 90219423
Swollen joint count 18.64 10.39 83 408853 8570 90210941
Labelled drug-food interaction issue 18.62 10.39 7 408929 34 90219477
Thyroid cancer 18.62 10.39 3 408933 6281 90213230
Convulsive threshold lowered 18.57 10.39 16 408920 450 90219061
Tongue biting 18.54 10.39 34 408902 2099 90217412
Blindness 18.36 10.39 60 408876 26508 90193003
Suppressed lactation 18.25 10.39 16 408920 461 90219050
Exposure via skin contact 18.24 10.39 13 408923 10692 90208819
Indifference 18.14 10.39 11 408925 175 90219336
Libido decreased 18.14 10.39 41 408895 2941 90216570
Product preparation error 18.10 10.39 12 408924 10249 90209262
Red cell distribution width increased 18.10 10.39 17 408919 12190 90207321
Haemophagocytic lymphohistiocytosis 18.10 10.39 26 408910 15433 90204078
Heart rate irregular 18.05 10.39 53 408883 24215 90195296
Metastasis 18.03 10.39 3 408933 6134 90213377
Splenomegaly 18.01 10.39 19 408917 12905 90206606
Polyp 18.00 10.39 6 408930 7638 90211873
Cholecystitis acute 17.98 10.39 10 408926 9394 90210117
Fear of weight gain 17.96 10.39 6 408930 19 90219492
Resting tremor 17.89 10.39 21 408915 862 90218649
Rectal haemorrhage 17.87 10.39 264 408672 82480 90137031
Mobility decreased 17.87 10.39 1338 407598 249396 89970115
Neurodegenerative disorder 17.87 10.39 15 408921 407 90219104
Delusional perception 17.86 10.39 12 408924 230 90219281
Teratoma benign 17.85 10.39 8 408928 65 90219446
Organising pneumonia 17.82 10.39 6 408930 7591 90211920
Nerve compression 17.78 10.39 13 408923 10553 90208958
Rash papular 17.78 10.39 41 408895 20314 90199197
Pyelonephritis 17.78 10.39 44 408892 21272 90198239
Pharyngitis 17.76 10.39 46 408890 21901 90197610
Cholecystitis 17.73 10.39 31 408905 17009 90202502
Fistula 17.73 10.39 17 408919 12072 90207439
Lymphopenia 17.73 10.39 49 408887 22832 90196679
Aortic bruit 17.73 10.39 6 408930 20 90219491
Scoliosis 17.72 10.39 9 408927 8898 90210613
Areflexia 17.69 10.39 46 408890 3607 90215904
Oropharyngeal spasm 17.68 10.39 13 408923 289 90219222
Facial pain 17.68 10.39 20 408916 13162 90206349
Cyclothymic disorder 17.68 10.39 12 408924 234 90219277
Paronychia 17.64 10.39 7 408929 7999 90211512
Child abuse 17.62 10.39 4 408932 0 90219511
Drug level above therapeutic 17.59 10.39 62 408874 5747 90213764
Dementia with Lewy bodies 17.59 10.39 15 408921 416 90219095
Wrist fracture 17.59 10.39 27 408909 15597 90203914
Breast engorgement 17.58 10.39 9 408927 101 90219410
Chronic obstructive pulmonary disease 17.57 10.39 231 408705 73598 90145913
Ventricular arrhythmia 17.54 10.39 51 408885 4270 90215241
Throat tightness 17.46 10.39 71 408865 29413 90190098
Folliculitis 17.46 10.39 1107 407829 203246 90016265
Electrocardiogram T wave inversion 17.45 10.39 46 408890 3637 90215874
Grandiosity 17.42 10.39 13 408923 296 90219215
Postmortem blood drug level abnormal 17.42 10.39 12 408924 240 90219271
Haemoglobin increased 17.39 10.39 6 408930 7475 90212036
Somatic symptom disorder of pregnancy 17.35 10.39 9 408927 104 90219407
Compression fracture 17.31 10.39 9 408927 8780 90210731
Psychogenic tremor 17.29 10.39 6 408930 22 90219489
Fibrosis 17.28 10.39 3 408933 5949 90213562
Brain injury 17.26 10.39 75 408861 7663 90211848
Blood creatinine increased 17.19 10.39 338 408598 101048 90118463
Glaucoma 17.18 10.39 43 408893 20712 90198799
Congenital multiplex arthrogryposis 17.15 10.39 8 408928 72 90219439
Delusional disorder, unspecified type 17.14 10.39 15 408921 431 90219080
Epstein-Barr virus infection 17.06 10.39 13 408923 10331 90209180
Spinal pain 17.04 10.39 28 408908 15739 90203772
Distal intestinal obstruction syndrome 16.98 10.39 16 408920 507 90219004
Gait disturbance 16.90 10.39 1380 407556 259116 89960395
Hypoglycaemia neonatal 16.88 10.39 23 408913 1099 90218412
Vaginal haemorrhage 16.87 10.39 78 408858 31193 90188318
Hallucination, olfactory 16.87 10.39 13 408923 311 90219200
Diarrhoea haemorrhagic 16.83 10.39 14 408922 10649 90208862
Skin irritation 16.81 10.39 22 408914 13581 90205930
Claustrophobia 16.72 10.39 25 408911 1302 90218209
Violence-related symptom 16.68 10.39 17 408919 594 90218917
Bladder cancer 16.68 10.39 3 408933 5798 90213713
Subdural haematoma 16.68 10.39 31 408905 16614 90202897
Parkinsonian rest tremor 16.67 10.39 10 408926 156 90219355
Colitis ischaemic 16.64 10.39 104 408832 12242 90207269
Peripheral coldness 16.63 10.39 23 408913 13869 90205642
Cyanosis 16.57 10.39 147 408789 19308 90200203
Neonatal hypotension 16.55 10.39 10 408926 158 90219353
Immune effector cell-associated neurotoxicity syndrome 16.55 10.39 3 408933 5765 90213746
Torticollis 16.49 10.39 36 408900 2522 90216989
Aortic arteriosclerosis 16.47 10.39 7 408929 7677 90211834
Scleroderma 16.43 10.39 4 408932 6257 90213254
Acidosis 16.37 10.39 106 408830 12630 90206881
Hiatus hernia 16.35 10.39 59 408877 25302 90194209
Eosinophil count increased 16.32 10.39 21 408915 13060 90206451
Renal function test abnormal 16.32 10.39 6 408930 7185 90212326
Chorea 16.31 10.39 32 408904 2078 90217433
Sensitivity to weather change 16.31 10.39 10 408926 8904 90210607
Injection site discolouration 16.30 10.39 11 408925 9309 90210202
Labelled drug-food interaction medication error 16.28 10.39 12 408924 268 90219243
Starvation ketoacidosis 16.23 10.39 11 408925 214 90219297
Aphonia 16.19 10.39 19 408917 12300 90207211
Agitation neonatal 16.15 10.39 16 408920 540 90218971
Patient uncooperative 16.12 10.39 12 408924 272 90219239
Cardiac failure acute 16.11 10.39 18 408918 11911 90207600
Acute coronary syndrome 16.10 10.39 15 408921 10798 90208713
Pyramidal tract syndrome 16.08 10.39 16 408920 543 90218968
Tooth abscess 16.06 10.39 31 408905 16382 90203129
Cardiac failure chronic 16.06 10.39 3 408933 5643 90213868
Epigastric discomfort 16.06 10.39 7 408929 7561 90211950
Adjustment disorder 16.05 10.39 12 408924 9630 90209881
Tendon rupture 16.05 10.39 11 408925 9232 90210279
Sudden death 16.04 10.39 94 408842 10815 90208696
Scar 16.03 10.39 28 408908 15367 90204144
Tooth extraction 15.96 10.39 17 408919 11496 90208015
Pleurisy 15.96 10.39 11 408925 9206 90210305
Tooth fracture 15.96 10.39 20 408916 12580 90206931
Asphyxia 15.96 10.39 69 408867 7034 90212477
Cholelithiasis 15.95 10.39 329 408607 52177 90167334
Treatment failure 15.94 10.39 1168 407768 302760 89916751
Enterococcal infection 15.92 10.39 13 408923 9978 90209533
Ovarian cyst 15.85 10.39 34 408902 17284 90202227
Brain hypoxia 15.84 10.39 16 408920 553 90218958
Bradycardia neonatal 15.83 10.39 22 408914 1071 90218440
Hydrocephalus 15.79 10.39 4 408932 6090 90213421
Eosinopenia 15.76 10.39 8 408928 88 90219423
Poor venous access 15.75 10.39 41 408895 19486 90200025
Sarcoidosis 15.71 10.39 92 408844 10581 90208930
Selective eating disorder 15.71 10.39 31 408905 2022 90217489
Communication disorder 15.69 10.39 41 408895 3225 90216286
Lumbar vertebral fracture 15.66 10.39 7 408929 7451 90212060
Language disorder 15.62 10.39 36 408900 2616 90216895
Gingival bleeding 15.61 10.39 27 408909 14876 90204635
Compulsive sexual behaviour 15.61 10.39 7 408929 57 90219454
Genital haemorrhage 15.59 10.39 10 408926 8692 90210819
Swelling 15.57 10.39 1654 407282 417404 89802107
Bladder dilatation 15.56 10.39 21 408915 994 90218517
Hand deformity 15.56 10.39 1546 407390 294816 89924695
Alopecia 15.45 10.39 1977 406959 493094 89726417
Haemolytic anaemia 15.42 10.39 18 408918 11679 90207832
Food craving 15.41 10.39 30 408906 1937 90217574
Meniscus injury 15.40 10.39 9 408927 8228 90211283
Clinomania 15.35 10.39 6 408930 33 90219478
Enthesopathy 15.28 10.39 12 408924 9392 90210119
Parasomnia 15.26 10.39 17 408919 659 90218852
Incorrect product administration duration 15.26 10.39 41 408895 19281 90200230
Bone lesion 15.25 10.39 5 408931 6432 90213079
Keratosis follicular 15.16 10.39 5 408931 15 90219496
Stress 15.15 10.39 267 408669 81128 90138383
Discomfort 15.12 10.39 1436 407500 272899 89946612
Compulsive shopping 15.10 10.39 18 408918 751 90218760
Purulent discharge 15.10 10.39 3 408933 5402 90214109
Vestibular migraine 15.10 10.39 11 408925 241 90219270
Gait deviation 15.10 10.39 7 408929 62 90219449
Decreased interest 15.08 10.39 49 408887 4358 90215153
Trismus 15.07 10.39 52 408884 4769 90214742
Lung opacity 15.06 10.39 61 408875 6041 90213470
Drug diversion 15.05 10.39 21 408915 1026 90218485
Deafness neurosensory 15.04 10.39 6 408930 6835 90212676
Oesophageal candidiasis 15.00 10.39 6 408930 6823 90212688
Abnormal loss of weight 14.98 10.39 6 408930 6817 90212694
Electrocardiogram ST segment elevation 14.97 10.39 46 408890 3970 90215541
Retinal detachment 14.97 10.39 6 408930 6816 90212695
Haemolysis 14.95 10.39 10 408926 8500 90211011
Chromaturia 14.93 10.39 41 408895 19146 90200365
Dissociative amnesia 14.92 10.39 6 408930 36 90219475
Ammonia increased 14.91 10.39 53 408883 4933 90214578
Rapid eye movement sleep behaviour disorder 14.90 10.39 13 408923 372 90219139
Radial nerve palsy 14.89 10.39 16 408920 595 90218916
Confabulation 14.86 10.39 12 408924 308 90219203
Musculoskeletal chest pain 14.82 10.39 56 408880 23694 90195817
Product substitution issue 14.80 10.39 135 408801 17873 90201638
Ovarian cancer 14.77 10.39 6 408930 6761 90212750
Induced abortion failed 14.73 10.39 10 408926 195 90219316
Hernia 14.71 10.39 26 408910 14205 90205306
Peritonitis 14.68 10.39 43 408893 19662 90199849
Knee arthroplasty 14.67 10.39 485 408451 82697 90136814
Abnormal dreams 14.66 10.39 94 408842 11163 90208348
Pupillary light reflex tests abnormal 14.61 10.39 11 408925 254 90219257
Poverty of speech 14.59 10.39 12 408924 316 90219195
Nystagmus 14.58 10.39 68 408868 7159 90212352
Flight of ideas 14.54 10.39 14 408922 456 90219055
Haemorrhage intracranial 14.53 10.39 29 408907 15133 90204378
Gastrointestinal inflammation 14.52 10.39 6 408930 6690 90212821
Vomiting 14.50 10.39 3242 405694 785051 89434460
Endocarditis 14.44 10.39 7 408929 7106 90212405
Formication 14.39 10.39 51 408885 4740 90214771
Resuscitation 14.35 10.39 23 408913 1273 90218238
Dialysis 14.33 10.39 18 408918 11311 90208200
Cataract operation 14.23 10.39 5 408931 6158 90213353
Hepatic lesion 14.17 10.39 4 408932 5669 90213842
Frontotemporal dementia 14.17 10.39 13 408923 398 90219113
Herpes simplex 14.15 10.39 15 408921 10166 90209345
Postmortem blood drug level 14.15 10.39 8 408928 111 90219400
Unintentional medical device removal 14.14 10.39 7 408929 7023 90212488
Drug resistance 14.13 10.39 80 408856 30369 90189142
Eye inflammation 14.09 10.39 9 408927 7842 90211669
Autoimmune haemolytic anaemia 14.07 10.39 4 408932 5641 90213870
Skin mass 14.06 10.39 8 408928 7422 90212089
Tongue movement disturbance 14.06 10.39 13 408923 402 90219109
Cardiac tamponade 14.02 10.39 4 408932 5628 90213883
Large intestine polyp 14.00 10.39 13 408923 9373 90210138
Lung infiltration 13.99 10.39 30 408906 15252 90204259
Staphylococcal sepsis 13.99 10.39 13 408923 9370 90210141
Pseudobulbar palsy 13.98 10.39 4 408932 6 90219505
Invasive ductal breast carcinoma 13.98 10.39 9 408927 7809 90211702
Gastrointestinal pain 13.97 10.39 18 408918 11188 90208323
Neonatal respiratory distress syndrome 13.96 10.39 38 408898 3063 90216448
Urosepsis 13.95 10.39 49 408887 21183 90198328
CYP2D6 polymorphism 13.95 10.39 7 408929 75 90219436
Ear pain 13.93 10.39 180 408756 57522 90161989
Mental status changes 13.92 10.39 281 408655 44398 90175113
Hypoalbuminaemia 13.90 10.39 32 408904 15865 90203646
Parosmia 13.89 10.39 66 408870 7003 90212508
Hypersensitivity myocarditis 13.86 10.39 11 408925 275 90219236
Thyroid disorder 13.85 10.39 38 408898 17747 90201764
Acute myopia 13.83 10.39 9 408927 163 90219348
Paralysis 13.82 10.39 94 408842 11384 90208127
Catheter site pain 13.82 10.39 4 408932 5575 90213936
Total cholesterol/HDL ratio abnormal 13.79 10.39 7 408929 77 90219434
Manic symptom 13.79 10.39 7 408929 77 90219434
Infusion related reaction 13.79 10.39 1658 407278 415122 89804389
Eye movement disorder 13.77 10.39 60 408876 6138 90213373
Lung adenocarcinoma 13.76 10.39 4 408932 5561 90213950
Eye pain 13.76 10.39 130 408806 44038 90175473
Sinus headache 13.72 10.39 6 408930 6470 90213041
Acne 13.72 10.39 74 408862 28433 90191078
Fear of injection 13.67 10.39 11 408925 8504 90211007
Nasal polyps 13.64 10.39 90 408846 10790 90208721
Bruxism 13.59 10.39 47 408889 4316 90215195
Device leakage 13.58 10.39 15 408921 9976 90209535
Muscle twitching 13.57 10.39 168 408768 24034 90195477
Antinuclear antibody positive 13.55 10.39 13 408923 9228 90210283
Hostility 13.55 10.39 31 408905 2242 90217269
Skin warm 13.54 10.39 9 408927 7678 90211833
Skin hyperpigmentation 13.52 10.39 7 408929 6844 90212667
Sideroblastic anaemia 13.52 10.39 5 408931 23 90219488
Haematocrit decreased 13.52 10.39 122 408814 41710 90177801
Hypocalcaemia 13.50 10.39 124 408812 42244 90177267
Rhinovirus infection 13.49 10.39 5 408931 5958 90213553
Defect conduction intraventricular 13.46 10.39 10 408926 226 90219285
Orthopnoea 13.46 10.39 7 408929 6828 90212683
Overlap syndrome 13.45 10.39 75 408861 8473 90211038
Eosinophilic cellulitis 13.42 10.39 10 408926 227 90219284
Pharyngitis streptococcal 13.42 10.39 23 408913 12719 90206792
Incorrect dose administered 13.42 10.39 263 408673 78667 90140844
Multiple organ dysfunction syndrome 13.42 10.39 222 408714 68114 90151397
Blood cholesterol decreased 13.40 10.39 28 408908 1903 90217608
Temperature intolerance 13.34 10.39 21 408915 12009 90207502
Spinal disorder 13.32 10.39 20 408916 11659 90207852
Pupillary reflex impaired 13.32 10.39 33 408903 2512 90216999
Oligohydramnios 13.28 10.39 8 408928 7193 90212318
Blood pressure diastolic decreased 13.27 10.39 69 408867 26757 90192754
Staphylococcal infection 13.26 10.39 147 408789 48292 90171219
Neonatal oversedation 13.26 10.39 4 408932 8 90219503
Congestive cardiomyopathy 13.26 10.39 67 408869 7287 90212224
Antipsychotic drug level above therapeutic 13.23 10.39 23 408913 1361 90218150
Coagulopathy 13.22 10.39 57 408879 23232 90196279
Erotomanic delusion 13.22 10.39 3 408933 0 90219511
Schizotypal personality disorder 13.22 10.39 3 408933 0 90219511
Diabetic cardiomyopathy 13.22 10.39 3 408933 0 90219511
Exaggerated startle response 13.22 10.39 3 408933 0 90219511
Hypothermia neonatal 13.22 10.39 3 408933 0 90219511
Micrographia 13.22 10.39 3 408933 0 90219511
Buccoglossal syndrome 13.22 10.39 3 408933 0 90219511
Cholangitis 13.22 10.39 8 408928 7174 90212337
Dopamine dysregulation syndrome 13.19 10.39 9 408927 177 90219334
CSWS syndrome 13.18 10.39 5 408931 25 90219486
Irregular sleep phase 13.18 10.39 5 408931 25 90219486
Pulmonary hypoplasia 13.15 10.39 12 408924 365 90219146
Ear discomfort 13.12 10.39 16 408920 10184 90209327
Crying 13.11 10.39 175 408761 25470 90194041
Impaired work ability 13.11 10.39 44 408892 19282 90200229
Neuropsychiatric symptoms 13.10 10.39 16 408920 685 90218826
Abdominal abscess 13.09 10.39 4 408932 5383 90214128
Angina unstable 13.08 10.39 8 408928 7135 90212376
False positive investigation result 13.07 10.39 17 408919 776 90218735
Spondylitis 13.06 10.39 109 408827 14069 90205442
Hyperuricaemia 13.06 10.39 7 408929 6712 90212799
Hepatic cancer 13.04 10.39 3 408933 4878 90214633
Wound dehiscence 12.98 10.39 5 408931 5817 90213694
Faeces soft 12.96 10.39 9 408927 7502 90212009
Gastric haemorrhage 12.95 10.39 8 408928 7095 90212416
Somatic hallucination 12.95 10.39 4 408932 9 90219502
Complication of device removal 12.93 10.39 6 408930 6249 90213262
Waxy flexibility 12.89 10.39 8 408928 133 90219378
Bone marrow eosinophilic leukocyte count increased 12.87 10.39 5 408931 27 90219484
Panic disorder 12.87 10.39 37 408899 3078 90216433
Haemorrhoidal haemorrhage 12.85 10.39 4 408932 5319 90214192
Agitated depression 12.85 10.39 12 408924 376 90219135
Malignant polyp 12.85 10.39 9 408927 185 90219326
Visceral congestion 12.80 10.39 12 408924 378 90219133
Pain of skin 12.79 10.39 34 408902 16048 90203463
Deep vein thrombosis 12.78 10.39 315 408621 91305 90128206
Electroconvulsive therapy 12.77 10.39 6 408930 55 90219456
Retinal haemorrhage 12.76 10.39 5 408931 5759 90213752
Insurance issue 12.76 10.39 89 408847 10869 90208642
Stress fracture 12.76 10.39 12 408924 8599 90210912
Product administration interrupted 12.75 10.39 23 408913 12469 90207042
Joint noise 12.73 10.39 4 408932 5286 90214225
Genital labial adhesions 12.72 10.39 5 408931 28 90219483
Device related sepsis 12.70 10.39 3 408933 4790 90214721
Food refusal 12.70 10.39 15 408921 620 90218891
Oscillopsia 12.68 10.39 8 408928 137 90219374
Small intestinal obstruction 12.66 10.39 51 408885 21183 90198328
Retrograde amnesia 12.62 10.39 14 408922 540 90218971
Erythema nodosum 12.62 10.39 5 408931 5719 90213792
Ballismus 12.58 10.39 8 408928 139 90219372
Coronary artery occlusion 12.58 10.39 12 408924 8542 90210969
Immune-mediated enterocolitis 12.56 10.39 3 408933 4754 90214757
Serum ferritin increased 12.53 10.39 9 408927 7372 90212139
Suspiciousness 12.51 10.39 12 408924 389 90219122
Hydronephrosis 12.51 10.39 23 408913 12379 90207132
Heart rate increased 12.48 10.39 401 408535 112501 90107010
Iron deficiency 12.45 10.39 15 408921 9597 90209914
Leukopenia neonatal 12.43 10.39 5 408931 30 90219481
Mouth haemorrhage 12.41 10.39 12 408924 8489 90211022
Skin burning sensation 12.40 10.39 46 408890 19565 90199946
Sleep talking 12.39 10.39 20 408916 1113 90218398
Lung perforation 12.39 10.39 7 408929 97 90219414
Blood sodium increased 12.38 10.39 37 408899 3145 90216366
Asthma 12.38 10.39 1261 407675 240899 89978612
Pharyngeal swelling 12.37 10.39 16 408920 9928 90209583
Mass 12.34 10.39 33 408903 15544 90203967
Autoimmune myocarditis 12.34 10.39 10 408926 258 90219253
Glycosylated haemoglobin increased 12.30 10.39 33 408903 15529 90203982
Central nervous system injury 12.29 10.39 8 408928 145 90219366
Peritonitis bacterial 12.28 10.39 4 408932 5167 90214344
Immunosuppressant drug level increased 12.26 10.39 3 408933 4677 90214834
Pulse absent 12.24 10.39 57 408879 5998 90213513
Stoma site hypergranulation 12.21 10.39 12 408924 401 90219110
Haemoptysis 12.20 10.39 94 408842 33226 90186285
Gastric cancer 12.15 10.39 4 408932 5132 90214379
Breast discharge 12.14 10.39 21 408915 1238 90218273
Rhinitis 12.13 10.39 27 408909 13545 90205966
Compulsions 12.09 10.39 9 408927 204 90219307
Pulmonary pain 12.07 10.39 4 408932 5110 90214401
Eructation 12.06 10.39 19 408917 10863 90208648
Anuria 12.04 10.39 31 408905 14787 90204724
Pulmonary alveolar haemorrhage 12.03 10.39 6 408930 5992 90213519
Nasal discomfort 11.98 10.39 5 408931 5543 90213968
Tearfulness 11.97 10.39 48 408888 4732 90214779
Stoma site erythema 11.95 10.39 23 408913 1473 90218038
Encopresis 11.90 10.39 7 408929 105 90219406
Hygroma colli 11.89 10.39 4 408932 13 90219498
Respiratory rate increased 11.86 10.39 35 408901 15966 90203545
Erysipelas 11.86 10.39 14 408922 9038 90210473
Renal cancer 11.84 10.39 6 408930 5939 90213572
Goitre 11.82 10.39 8 408928 6759 90212752
Infusion site pruritus 11.81 10.39 8 408928 6757 90212754
Hip fracture 11.80 10.39 94 408842 32983 90186528
Cold sweat 11.79 10.39 29 408907 14052 90205459
Congenital anomaly 11.78 10.39 7 408929 6340 90213171
Bladder disorder 11.76 10.39 19 408917 10753 90208758
Lipase increased 11.76 10.39 20 408916 11091 90208420
Cardiomyopathy 11.75 10.39 49 408887 20157 90199354
Jealous delusion 11.74 10.39 6 408930 67 90219444
Obsessive-compulsive symptom 11.73 10.39 7 408929 108 90219403
Drug reaction with eosinophilia and systemic symptoms 11.73 10.39 264 408672 42494 90177017
Scab 11.73 10.39 16 408920 9705 90209806
Gait apraxia 11.67 10.39 5 408931 36 90219475
Non-cardiac chest pain 11.67 10.39 8 408928 6713 90212798
Eye discharge 11.67 10.39 12 408924 8246 90211265
Large for dates baby 11.62 10.39 13 408923 506 90219005
Drowning 11.62 10.39 13 408923 506 90219005
Secretion discharge 11.62 10.39 35 408901 15861 90203650
Cholinergic syndrome 11.60 10.39 15 408921 681 90218830
Anterior displaced anus 11.59 10.39 6 408930 69 90219442
Stress cardiomyopathy 11.59 10.39 27 408909 13328 90206183
Red blood cell sedimentation rate abnormal 11.56 10.39 63 408873 24141 90195370
Allergic hepatitis 11.55 10.39 5 408931 37 90219474
Autoimmune hepatitis 11.54 10.39 18 408918 10333 90209178
Back disorder 11.53 10.39 171 408765 25460 90194051
Electrocardiogram change 11.53 10.39 16 408920 778 90218733
Systemic candida 11.49 10.39 4 408932 4955 90214556
Proctalgia 11.48 10.39 12 408924 8186 90211325
Catheterisation cardiac 11.48 10.39 4 408932 4952 90214559
Duplicate therapy error 11.46 10.39 7 408929 113 90219398
Limb discomfort 11.44 10.39 113 408823 37947 90181564
Injury associated with device 11.43 10.39 3 408933 4461 90215050
Sinus pain 11.41 10.39 5 408931 5384 90214127
Orthostatic hypotension 11.40 10.39 258 408678 41569 90177942
Neurological symptom 11.39 10.39 61 408875 6786 90212725
Multiple-drug resistance 11.33 10.39 11 408925 7765 90211746
Urine output decreased 11.32 10.39 25 408911 12578 90206933
Ovarian germ cell cancer stage II 11.30 10.39 6 408930 73 90219438
Thrombocytosis 11.29 10.39 9 408927 6992 90212519
Cardiopulmonary failure 11.25 10.39 43 408893 4145 90215366
Catheter site erythema 11.25 10.39 4 408932 4890 90214621
Wrong product administered 11.24 10.39 66 408870 7599 90211912
Pericardial effusion 11.22 10.39 109 408827 36724 90182787
Pollakiuria 11.22 10.39 95 408841 32910 90186601
Necrotising colitis 11.22 10.39 21 408915 1317 90218194
Reduced facial expression 11.21 10.39 31 408905 2522 90216989
Blindness unilateral 11.21 10.39 11 408925 7725 90211786
Hordeolum 11.19 10.39 4 408932 4874 90214637
Congenital emphysema 11.15 10.39 3 408933 3 90219508
22q11.2 deletion syndrome 11.15 10.39 3 408933 3 90219508
Electrolyte substitution therapy 11.15 10.39 3 408933 3 90219508
Graft versus host disease in gastrointestinal tract 11.14 10.39 3 408933 4385 90215126
Heparin-induced thrombocytopenia 11.13 10.39 5 408931 5307 90214204
Increased appetite 11.13 10.39 91 408845 11674 90207837
Freezing phenomenon 11.12 10.39 25 408911 1787 90217724
Oesophageal pain 11.09 10.39 3 408933 4371 90215140
Parkinsonism hyperpyrexia syndrome 11.08 10.39 9 408927 233 90219278
Intentional dose omission 11.05 10.39 42 408894 17741 90201770
Pulmonary artery stenosis congenital 11.02 10.39 12 408924 453 90219058
Oral infection 11.02 10.39 5 408931 5275 90214236
Blood creatinine decreased 10.99 10.39 8 408928 6507 90213004
Electroencephalogram abnormal 10.96 10.39 42 408894 4054 90215457
Device failure 10.96 10.39 9 408927 6888 90212623
Unmasking of previously unidentified disease 10.95 10.39 22 408914 1454 90218057
Housebound 10.95 10.39 9 408927 237 90219274
Dysaesthesia 10.93 10.39 5 408931 5250 90214261
Sleep disorder due to general medical condition, hypersomnia type 10.93 10.39 27 408909 2052 90217459
Haemangioma congenital 10.90 10.39 13 408923 543 90218968
Lactate pyruvate ratio increased 10.88 10.39 6 408930 79 90219432
Mouth swelling 10.86 10.39 6 408930 5656 90213855
Metabolic alkalosis 10.85 10.39 38 408898 3511 90216000
Floppy infant 10.84 10.39 7 408929 125 90219386
Cholecystectomy 10.82 10.39 23 408913 11732 90207779
Diabetic hyperosmolar coma 10.78 10.39 11 408925 385 90219126
Burnout syndrome 10.76 10.39 9 408927 243 90219268
Female sexual dysfunction 10.75 10.39 6 408930 81 90219430
Therapy partial responder 10.73 10.39 57 408879 21986 90197525
Injection site extravasation 10.73 10.39 15 408921 9004 90210507
Sudden cardiac death 10.70 10.39 28 408908 2204 90217307
Uterine perforation 10.65 10.39 11 408925 7543 90211968
Toxic skin eruption 10.64 10.39 36 408900 15738 90203773
Blood glucose decreased 10.63 10.39 62 408874 23367 90196144
Trigger finger 10.63 10.39 5 408931 5165 90214346
Brain natriuretic peptide increased 10.62 10.39 7 408929 5998 90213513
Presyncope 10.61 10.39 92 408844 31713 90187798
Myoclonic epilepsy 10.61 10.39 23 408913 1604 90217907
Foetal macrosomia 10.60 10.39 9 408927 248 90219263
Autonomic nervous system imbalance 10.60 10.39 37 408899 3413 90216098
Nasal dryness 10.58 10.39 6 408930 5577 90213934
Aortic valve stenosis 10.57 10.39 3 408933 4237 90215274
Dyslipidaemia 10.57 10.39 80 408856 10027 90209484
Hepatic steatosis 10.57 10.39 111 408825 36834 90182677
Dysmetropsia 10.56 10.39 6 408930 84 90219427
Oesophagitis 10.55 10.39 41 408895 17208 90202303
Intestinal perforation 10.55 10.39 30 408906 13851 90205660
Intellectual disability 10.55 10.39 20 408916 1266 90218245
Blood alkaline phosphatase increased 10.52 10.39 153 408783 47926 90171585
C-reactive protein increased 10.51 10.39 691 408245 180698 90038813
Vascular device infection 10.50 10.39 24 408912 11928 90207583
Myopathy 10.44 10.39 29 408907 13489 90206022
Reflexes abnormal 10.43 10.39 15 408921 754 90218757
Diabetic complication 10.41 10.39 17 408919 956 90218555
Escherichia urinary tract infection 10.40 10.39 30 408906 13785 90205726
Affect lability 10.40 10.39 126 408810 17937 90201574
Caudal regression syndrome 10.40 10.39 8 408928 191 90219320
Haemoglobin abnormal 10.39 10.39 10 408926 7090 90212421

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2228.35 11.79 2321 169224 94144 42355646
Toxicity to various agents 2163.99 11.79 3540 168005 225596 42224194
Neuroleptic malignant syndrome 2110.59 11.79 1224 170321 20248 42429542
Suicide attempt 1933.32 11.79 1551 169994 44549 42405241
Drug interaction 1445.36 11.79 3259 168286 263740 42186050
Sopor 1405.19 11.79 793 170752 12409 42437381
Intentional overdose 1333.73 11.79 1319 170226 50137 42399653
Drug abuse 1081.09 11.79 1689 169856 103082 42346708
Overdose 1026.84 11.79 1654 169891 103610 42346180
Sedation 958.70 11.79 870 170675 29605 42420185
Psychotic disorder 936.83 11.79 843 170702 28365 42421425
Agitation 895.87 11.79 1196 170349 63118 42386672
Somnolence 852.25 11.79 1803 169742 139302 42310488
Coma 825.36 11.79 1047 170498 52507 42397283
Aggression 805.02 11.79 940 170605 43223 42406567
Depression 793.92 11.79 1525 170020 109838 42339952
Extrapyramidal disorder 773.12 11.79 592 170953 15820 42433970
Priapism 639.01 11.79 369 171176 6038 42443752
Depressed level of consciousness 628.10 11.79 866 170679 47104 42402686
Suicidal ideation 625.43 11.79 866 170679 47295 42402495
Tardive dyskinesia 625.41 11.79 374 171171 6550 42443240
Dyskinesia 622.54 11.79 632 170913 24758 42425032
Akathisia 612.08 11.79 430 171115 10021 42439769
Dystonia 592.83 11.79 457 171088 12333 42437457
Intentional self-injury 580.77 11.79 485 171060 14717 42435073
Diarrhoea 573.27 11.79 608 170937 460241 41989549
Paranoia 549.37 11.79 454 171091 13572 42436218
Hallucination 519.93 11.79 874 170671 56633 42393157
Delusion 505.56 11.79 442 171103 14292 42435498
Parkinsonism 497.64 11.79 382 171163 10241 42439549
Electrocardiogram QT prolonged 485.35 11.79 767 170778 47178 42402612
Serotonin syndrome 432.65 11.79 527 171018 25318 42424472
Dyspnoea 429.16 11.79 702 170843 441919 42007871
Febrile neutropenia 420.23 11.79 114 171431 185589 42264201
Muscle rigidity 414.20 11.79 362 171183 11697 42438093
Catatonia 406.10 11.79 274 171271 5965 42443825
Restlessness 399.27 11.79 539 171006 28710 42421080
Poisoning deliberate 396.79 11.79 328 171217 9806 42439984
Mania 367.05 11.79 319 171226 10228 42439562
Foetal exposure during pregnancy 363.98 11.79 670 170875 46641 42403149
Psychiatric decompensation 357.94 11.79 219 171326 4003 42445787
Hallucination, auditory 351.57 11.79 363 171182 14501 42435289
Rash 323.04 11.79 384 171161 276570 42173220
Poisoning 320.97 11.79 344 171201 14355 42435435
Obsessive-compulsive disorder 319.14 11.79 244 171301 6499 42443291
Delirium 314.92 11.79 670 170875 51849 42397941
Disease progression 306.93 11.79 98 171447 143558 42306232
Arthralgia 306.89 11.79 227 171318 205011 42244779
Confusional state 305.72 11.79 1410 170135 166187 42283603
Nausea 299.35 11.79 728 170817 396071 42053719
Rhabdomyolysis 291.54 11.79 830 170715 77189 42372601
Anaemia 289.65 11.79 425 171120 279853 42169937
Pneumonia 287.64 11.79 815 170730 421334 42028456
Abnormal behaviour 284.07 11.79 435 171110 26016 42423774
Altered state of consciousness 283.51 11.79 459 171086 28800 42420990
Drug withdrawal syndrome neonatal 281.01 11.79 192 171353 4269 42445521
Malignant neoplasm progression 276.26 11.79 51 171494 108349 42341441
Psychomotor hyperactivity 272.57 11.79 275 171270 10683 42439107
Fatigue 268.98 11.79 880 170665 434761 42015029
Blood creatine phosphokinase increased 266.27 11.79 596 170949 47742 42402048
Euphoric mood 263.39 11.79 214 171331 6239 42443551
Hallucination, visual 260.79 11.79 370 171175 20650 42429140
Bradyphrenia 243.75 11.79 188 171357 5074 42444716
Anxiety 243.67 11.79 1034 170511 117526 42332264
Antipsychotic drug level below therapeutic 240.88 11.79 154 171391 3050 42446740
Oculogyric crisis 229.20 11.79 121 171424 1644 42448146
Cough 228.36 11.79 228 171317 177875 42271915
Tachycardia 227.71 11.79 907 170638 100180 42349610
Emotional poverty 223.12 11.79 90 171455 622 42449168
Pruritus 222.78 11.79 259 171286 188512 42261278
Tremor 222.60 11.79 875 170670 96054 42353736
Apathy 222.08 11.79 218 171327 8188 42441602
Diabetes mellitus 219.32 11.79 634 170911 59453 42390337
Tearfulness 218.95 11.79 150 171395 3350 42446440
Disinhibition 218.17 11.79 156 171389 3739 42446051
Depressive symptom 215.09 11.79 154 171391 3699 42446091
Depression suicidal 212.34 11.79 143 171402 3102 42446688
Psychomotor skills impaired 211.17 11.79 172 171373 5032 42444758
Blood prolactin abnormal 204.52 11.79 95 171450 960 42448830
Schizophrenia 202.83 11.79 231 171314 10319 42439471
Weight increased 201.47 11.79 915 170630 107068 42342722
Atrial fibrillation 198.84 11.79 162 171383 139431 42310359
Pyrexia 196.29 11.79 868 170677 393174 42056616
Irritability 189.94 11.79 377 171168 27751 42422039
Neuropathy peripheral 188.39 11.79 87 171458 101766 42348024
Hyperprolactinaemia 187.35 11.79 113 171432 2010 42447780
Intentional product misuse 186.64 11.79 611 170934 61289 42388501
Bradykinesia 186.28 11.79 163 171382 5273 42444517
Sepsis 186.09 11.79 323 171222 199011 42250779
Miosis 185.27 11.79 249 171296 13197 42436593
Therapeutic product effect variable 184.51 11.79 129 171416 2980 42446810
Sexual dysfunction 181.40 11.79 177 171368 6598 42443192
Prescribed overdose 177.52 11.79 239 171306 12688 42437102
Suspected suicide 175.50 11.79 167 171378 6032 42443758
Pain 175.05 11.79 461 171084 244387 42205403
COVID-19 172.14 11.79 129 171416 115819 42333971
Hyperreflexia 167.35 11.79 129 171416 3478 42446312
Psychomotor retardation 165.17 11.79 139 171406 4260 42445530
Psychotic symptom 162.83 11.79 108 171437 2282 42447508
Cardiac failure congestive 161.61 11.79 71 171474 85531 42364259
Cognitive disorder 159.45 11.79 395 171150 33777 42416013
Speech disorder 155.77 11.79 355 171190 28766 42421024
Disorientation 155.64 11.79 407 171138 35982 42413808
Depressed mood 154.98 11.79 311 171234 23073 42426717
Dementia 154.82 11.79 255 171290 16225 42433565
Pain in extremity 154.66 11.79 229 171316 150375 42299415
Increased appetite 154.52 11.79 185 171360 8721 42441069
Back pain 152.09 11.79 209 171336 141567 42308223
Salivary hypersecretion 151.31 11.79 203 171342 10740 42439050
Bezoar 150.33 11.79 82 171463 1194 42448596
Anosognosia 148.25 11.79 76 171469 968 42448822
Dysarthria 148.08 11.79 423 171122 39384 42410406
Joint swelling 147.68 11.79 45 171500 67977 42381813
Thrombocytopenia 143.07 11.79 349 171196 189930 42259860
Drug dependence 141.80 11.79 342 171203 28752 42421038
Cogwheel rigidity 141.46 11.79 89 171456 1712 42448078
Hypomania 139.44 11.79 100 171445 2408 42447382
Treatment noncompliance 135.96 11.79 396 171149 37276 42412514
Asthenia 135.68 11.79 625 170920 280168 42169622
Mental impairment 135.65 11.79 205 171340 12112 42437678
Pleural effusion 134.32 11.79 116 171429 97050 42352740
Social avoidant behaviour 134.00 11.79 110 171435 3254 42446536
Interstitial lung disease 133.15 11.79 75 171470 78387 42371403
Headache 132.84 11.79 505 171040 238864 42210926
Platelet count decreased 132.50 11.79 221 171324 138360 42311430
Decreased appetite 132.41 11.79 371 171174 192766 42257024
Infection 131.82 11.79 154 171391 111914 42337876
Persecutory delusion 130.50 11.79 111 171434 3453 42446337
Obesity 130.16 11.79 236 171309 16223 42433567
Mydriasis 129.45 11.79 168 171377 8602 42441188
Sedation complication 128.06 11.79 101 171444 2818 42446972
Respiratory disorder neonatal 126.96 11.79 86 171459 1884 42447906
Schizoaffective disorder 126.96 11.79 86 171459 1884 42447906
Haemoglobin decreased 126.89 11.79 211 171334 132260 42317530
Disturbance in social behaviour 126.54 11.79 83 171462 1720 42448070
Drug withdrawal syndrome 125.72 11.79 272 171273 21277 42428513
Restless legs syndrome 123.33 11.79 172 171373 9442 42440348
Hypertonia neonatal 121.58 11.79 56 171489 554 42449236
Urticaria 121.05 11.79 74 171471 73962 42375828
Insomnia 121.04 11.79 853 170692 117400 42332390
Withdrawal syndrome 120.86 11.79 215 171330 14560 42435230
Infusion related reaction 120.30 11.79 47 171498 60759 42389031
Pancytopenia 119.91 11.79 180 171365 117563 42332227
Drug hypersensitivity 119.68 11.79 134 171411 99255 42350535
Acute kidney injury 119.64 11.79 927 170618 366410 42083380
Myelosuppression 119.62 11.79 12 171533 40449 42409341
Respiratory arrest 119.58 11.79 316 171229 28108 42421682
Pneumonia aspiration 118.03 11.79 456 171089 49622 42400168
Stomatitis 117.29 11.79 29 171516 50300 42399490
Mental disorder 116.15 11.79 237 171308 17792 42431998
Type 2 diabetes mellitus 114.52 11.79 239 171306 18232 42431558
Bipolar disorder 113.58 11.79 107 171438 3815 42445975
Nasopharyngitis 112.82 11.79 103 171442 83893 42365897
Loss of consciousness 112.57 11.79 696 170849 91658 42358132
Rheumatoid arthritis 112.38 11.79 18 171527 42422 42407368
Cytokine release syndrome 109.07 11.79 23 171522 44504 42405286
Thinking abnormal 108.55 11.79 139 171406 7022 42442768
Blood prolactin increased 108.39 11.79 83 171462 2215 42447575
Thrombosis 107.19 11.79 72 171473 68439 42381351
Myocarditis 105.89 11.79 235 171310 18703 42431087
On and off phenomenon 105.05 11.79 97 171448 3370 42446420
Mucosal inflammation 104.77 11.79 34 171511 49340 42400450
Plasma cell myeloma 104.12 11.79 31 171514 47547 42402243
Diabetic coma 103.40 11.79 59 171486 942 42448848
Agitation neonatal 103.31 11.79 67 171478 1361 42448429
Antipsychotic drug level increased 99.73 11.79 108 171437 4558 42445232
Seizure 98.97 11.79 826 170719 119735 42330055
Hyperthermia 96.52 11.79 178 171367 12396 42437394
Coma scale abnormal 96.42 11.79 105 171440 4460 42445330
Ascites 94.97 11.79 55 171490 56623 42393167
Sinusitis 94.46 11.79 36 171509 47256 42402534
Cytomegalovirus infection 94.42 11.79 10 171535 32296 42417494
Metabolic syndrome 94.36 11.79 72 171473 1911 42447879
Drug screen positive 94.27 11.79 99 171446 4032 42445758
Dyspnoea exertional 93.98 11.79 42 171503 50106 42399684
Disturbance in attention 93.76 11.79 299 171246 29567 42420223
Abdominal pain 93.64 11.79 421 171124 190050 42259740
Anger 93.36 11.79 179 171366 12839 42436951
Productive cough 92.32 11.79 46 171499 51521 42398269
Multiple drug therapy 91.72 11.79 57 171488 1072 42448718
Delusional disorder, persecutory type 91.40 11.79 39 171506 316 42449474
Sinus tachycardia 91.38 11.79 234 171311 20419 42429371
Stupor 91.27 11.79 86 171459 3067 42446723
Unresponsive to stimuli 91.05 11.79 306 171239 31097 42418693
Small for dates baby 89.13 11.79 108 171437 5155 42444635
Suicidal behaviour 89.08 11.79 63 171482 1483 42448307
Gastrointestinal haemorrhage 88.68 11.79 161 171384 97565 42352225
Anaphylactic reaction 87.97 11.79 31 171514 42712 42407078
Herpes zoster 87.53 11.79 24 171521 38853 42410937
Pneumonitis 86.30 11.79 30 171515 41688 42408102
Oedema peripheral 86.24 11.79 271 171274 135805 42313985
Substance use disorder 86.18 11.79 107 171438 5238 42444552
Epistaxis 86.15 11.79 85 171460 66741 42383049
Substance abuse 85.27 11.79 139 171406 8766 42441024
Cardio-respiratory arrest 85.16 11.79 463 171082 58173 42391617
Homicidal ideation 84.32 11.79 78 171467 2716 42447074
Colitis 84.19 11.79 41 171504 46531 42403259
Selective eating disorder 83.83 11.79 64 171481 1700 42448090
Chronic obstructive pulmonary disease 82.84 11.79 79 171466 63035 42386755
Loss of personal independence in daily activities 82.49 11.79 408 171137 49408 42400382
Akinesia 82.45 11.79 73 171472 2399 42447391
Hypertriglyceridaemia 82.37 11.79 147 171398 9979 42439811
Hyperkinesia 82.31 11.79 68 171477 2030 42447760
Neoplasm progression 82.18 11.79 10 171535 28990 42420800
Neonatal respiratory distress syndrome 82.01 11.79 96 171449 4417 42445373
Weight decreased 81.79 11.79 496 171049 207452 42242338
Asthma 81.79 11.79 78 171467 62236 42387554
Posture abnormal 81.21 11.79 73 171472 2448 42447342
Metabolic disorder 80.67 11.79 98 171447 4690 42445100
Loss of libido 79.94 11.79 79 171466 2991 42446799
Torticollis 79.33 11.79 56 171489 1314 42448476
Pneumocystis jirovecii pneumonia 78.42 11.79 6 171539 25175 42424615
Bruxism 78.28 11.79 67 171478 2102 42447688
Erythema 78.22 11.79 204 171341 108589 42341201
Reduced facial expression 78.14 11.79 58 171487 1475 42448315
Abdominal discomfort 77.60 11.79 114 171431 75141 42374649
Hypotonia neonatal 77.56 11.79 57 171488 1427 42448363
Dysphoria 77.00 11.79 74 171471 2706 42447084
Chills 76.70 11.79 165 171380 93901 42355889
Myocardial infarction 76.45 11.79 250 171295 123759 42326031
Arthritis 76.09 11.79 37 171508 42028 42407762
Accidental death 75.98 11.79 77 171468 3006 42446784
Poor quality sleep 72.91 11.79 134 171411 9306 42440484
Malignant catatonia 72.76 11.79 36 171509 423 42449367
Acute myocardial infarction 72.68 11.79 76 171469 58089 42391701
Prostate cancer 72.43 11.79 45 171500 44598 42405192
Peripheral swelling 72.23 11.79 160 171385 90110 42359680
Myoclonus 72.05 11.79 190 171355 16875 42432915
Hyperkalaemia 71.70 11.79 134 171411 80324 42369466
Pulmonary fibrosis 71.35 11.79 11 171534 26670 42423120
Neonatal behavioural syndrome 71.27 11.79 27 171518 154 42449636
Antipsychotic drug level above therapeutic 70.93 11.79 51 171494 1233 42448557
Coronary artery disease 70.78 11.79 67 171478 53653 42396137
Vomiting 70.47 11.79 786 170759 288937 42160853
Renal impairment 70.19 11.79 219 171326 110009 42339781
Visceral congestion 70.17 11.79 45 171500 896 42448894
Respiratory depression 69.66 11.79 200 171345 18668 42431122
Logorrhoea 68.98 11.79 70 171475 2737 42447053
Malaise 68.12 11.79 537 171008 211619 42238171
Wheezing 67.97 11.79 72 171473 54709 42395081
Hypothermia 67.39 11.79 153 171392 12362 42437428
Lung disorder 66.45 11.79 57 171488 47866 42401924
Urinary retention 65.85 11.79 340 171205 41874 42407916
Freezing phenomenon 65.44 11.79 57 171488 1832 42447958
Haemorrhage 65.16 11.79 89 171456 60474 42389316
Hypersensitivity 64.95 11.79 120 171425 72250 42377540
Cellulitis 64.76 11.79 92 171453 61493 42388297
Faecaloma 64.33 11.79 101 171444 6169 42443621
Temperature regulation disorder 63.95 11.79 46 171499 1113 42448677
Haemoptysis 63.91 11.79 55 171490 46112 42403678
Generalised tonic-clonic seizure 63.60 11.79 242 171303 26137 42423653
Influenza 63.30 11.79 95 171450 62080 42387710
Death 62.82 11.79 1432 170113 469753 41980037
Sleep disorder 62.07 11.79 368 171177 47727 42402063
Alcohol abuse 62.01 11.79 79 171466 3970 42445820
Tension 61.56 11.79 62 171483 2402 42447388
Dissociation 61.18 11.79 76 171469 3722 42446068
Clonus 60.86 11.79 73 171472 3447 42446343
Septic shock 60.60 11.79 179 171366 91493 42358297
Blood pressure increased 60.41 11.79 209 171336 101719 42348071
Swelling 59.71 11.79 80 171465 54805 42394985
Bronchopulmonary aspergillosis 59.47 11.79 5 171540 19424 42430366
Hypokinesia 59.18 11.79 126 171419 9745 42440045
Dystonic tremor 59.12 11.79 29 171516 334 42449456
Palmar-plantar erythrodysaesthesia syndrome 58.56 11.79 7 171538 20575 42429215
Arthropathy 58.32 11.79 23 171522 29574 42420216
Injection site pain 58.18 11.79 89 171456 57709 42392081
Hypomagnesaemia 58.04 11.79 21 171524 28467 42421323
Acute myeloid leukaemia 57.67 11.79 10 171535 22246 42427544
Hypertonia 57.59 11.79 85 171460 4916 42444874
Psychosexual disorder 57.57 11.79 22 171523 129 42449661
Multiple organ dysfunction syndrome 57.48 11.79 199 171346 96836 42352954
Oedema 57.38 11.79 75 171470 51926 42397864
Fall 57.21 11.79 1290 170255 233230 42216560
Sexually inappropriate behaviour 57.15 11.79 34 171511 589 42449201
Personality change 57.12 11.79 91 171454 5628 42444162
Personality disorder 57.05 11.79 43 171502 1120 42448670
Psoriatic arthropathy 56.98 11.79 15 171530 24952 42424838
Major depression 56.84 11.79 88 171457 5310 42444480
Obstructive airways disorder 56.27 11.79 15 171530 24744 42425046
Upper respiratory tract infection 56.26 11.79 52 171493 42121 42407669
Affect lability 55.87 11.79 75 171470 3969 42445821
Drooling 55.27 11.79 77 171468 4222 42445568
Substance dependence 55.24 11.79 34 171511 628 42449162
Chest discomfort 54.88 11.79 108 171437 63508 42386282
Wrong product administered 54.03 11.79 93 171452 6133 42443657
Colitis ischaemic 53.84 11.79 101 171444 7125 42442665
Excessive eye blinking 53.60 11.79 33 171512 610 42449180
Electrocardiogram QRS complex prolonged 53.21 11.79 89 171456 5734 42444056
Sudden cardiac death 53.03 11.79 72 171473 3852 42445938
Rash pruritic 52.97 11.79 35 171510 33568 42416222
Illusion 52.60 11.79 39 171506 990 42448800
Cardiac failure 52.56 11.79 236 171309 106620 42343170
Blood triglycerides increased 52.51 11.79 162 171383 15734 42434056
Neutropenic sepsis 52.00 11.79 3 171542 15943 42433847
Abdominal distension 51.93 11.79 134 171411 71601 42378189
Spasmodic dysphonia 51.92 11.79 30 171515 491 42449299
Oppositional defiant disorder 51.91 11.79 31 171514 541 42449249
Trismus 51.83 11.79 61 171484 2823 42446967
Psychiatric symptom 51.62 11.79 74 171471 4167 42445623
Chest pain 51.62 11.79 339 171206 139191 42310599
Abulia 51.46 11.79 33 171512 657 42449133
Bone marrow failure 51.45 11.79 35 171510 33058 42416732
Cerebrovascular accident 51.21 11.79 209 171336 96951 42352839
Anticholinergic syndrome 51.16 11.79 46 171499 1543 42448247
Nephrolithiasis 50.82 11.79 44 171501 36786 42413004
Renal failure 50.77 11.79 354 171191 143372 42306418
Device related infection 50.64 11.79 10 171535 20269 42429521
Osteonecrosis of jaw 50.60 11.79 8 171537 19041 42430749
Behaviour disorder 50.58 11.79 97 171448 6957 42442833
Urinary incontinence 49.96 11.79 196 171349 21472 42428318
Haemophagocytic lymphohistiocytosis 49.91 11.79 7 171538 18215 42431575
Appendicitis 49.75 11.79 11 171534 20602 42429188
Panic attack 49.74 11.79 126 171419 10919 42438871
Brugada syndrome 49.59 11.79 38 171507 1015 42448775
Sleep disorder due to a general medical condition 49.50 11.79 6 171539 17447 42432343
Myelodysplastic syndrome 49.43 11.79 15 171530 22730 42427060
Congestive cardiomyopathy 49.26 11.79 109 171436 8655 42441135
Skin exfoliation 48.93 11.79 57 171488 41496 42408294
Stoma site erythema 48.78 11.79 37 171508 973 42448817
Penile abscess 48.77 11.79 20 171525 145 42449645
Skin ulcer 48.66 11.79 21 171524 25580 42424210
Dyslipidaemia 48.35 11.79 113 171432 9305 42440485
Blood creatinine increased 48.27 11.79 253 171292 109750 42340040
Tubulointerstitial nephritis 48.20 11.79 34 171511 31514 42418276
Somnambulism 48.20 11.79 64 171481 3351 42446439
Diet refusal 48.14 11.79 24 171521 287 42449503
Dry skin 48.10 11.79 75 171470 48263 42401527
Full blood count decreased 47.60 11.79 12 171533 20548 42429242
Granulocytopenia 47.58 11.79 95 171450 7019 42442771
Chronic kidney disease 47.30 11.79 73 171472 47168 42402622
Sleep-related eating disorder 46.88 11.79 25 171520 347 42449443
Gambling disorder 46.80 11.79 46 171499 1730 42448060
Flushing 46.68 11.79 48 171497 36980 42412810
Haematuria 46.59 11.79 102 171443 57697 42392093
Decreased eye contact 46.57 11.79 28 171517 495 42449295
Rectal haemorrhage 46.53 11.79 80 171465 49526 42400264
Slow speech 46.49 11.79 46 171499 1744 42448046
Suspiciousness 46.24 11.79 26 171519 403 42449387
Hypospadias 46.02 11.79 64 171481 3503 42446287
Full blood count abnormal 45.91 11.79 32 171513 29844 42419946
Gout 45.89 11.79 28 171517 28027 42421763
Stereotypy 45.50 11.79 33 171512 809 42448981
Paraesthesia 45.31 11.79 148 171397 73311 42376479
Atrial septal defect 45.09 11.79 99 171446 7820 42441970
Product dose omission issue 44.86 11.79 401 171144 153964 42295826
Impulsive behaviour 44.76 11.79 52 171493 2373 42447417
Diverticulitis 44.38 11.79 18 171527 22755 42427035
Feeling jittery 44.14 11.79 71 171474 4427 42445363
Paradoxical drug reaction 44.07 11.79 73 171472 4665 42445125
Neonatal tachypnoea 44.03 11.79 24 171521 349 42449441
Muscular weakness 43.76 11.79 180 171365 83318 42366472
Decerebrate posture 43.60 11.79 18 171527 133 42449657
Blood bilirubin increased 43.55 11.79 64 171481 42188 42407602
Diabetic ketoacidosis 43.48 11.79 192 171353 22175 42427615
Incoherent 43.33 11.79 72 171473 4613 42445177
Anticonvulsant drug level above therapeutic 43.28 11.79 30 171515 683 42449107
Oropharyngeal pain 43.22 11.79 65 171480 42445 42407345
Aspiration 43.04 11.79 164 171381 17722 42432068
Transplant rejection 42.99 11.79 3 171542 13585 42436205
Judgement impaired 42.90 11.79 28 171517 575 42449215
Derealisation 42.80 11.79 32 171513 823 42448967
Flight of ideas 42.77 11.79 23 171522 325 42449465
Hypoaesthesia 42.69 11.79 146 171399 71317 42378473
Haematochezia 42.41 11.79 109 171436 58327 42391463
Hyperammonaemia 42.17 11.79 96 171449 7770 42442020
Vein of Galen aneurysmal malformation 42.13 11.79 11 171534 11 42449779
Epilepsy 41.65 11.79 212 171333 25959 42423831
Pseudomonas infection 41.60 11.79 7 171538 15916 42433874
Poverty of speech 41.50 11.79 20 171525 221 42449569
Tonic posturing 41.48 11.79 12 171533 23 42449767
Neuralgia 41.39 11.79 26 171519 25621 42424169
Libido increased 41.11 11.79 33 171512 945 42448845
Neurodegenerative disorder 41.10 11.79 24 171521 401 42449389
Otospondylomegaepiphyseal dysplasia 41.02 11.79 16 171529 100 42449690
Prostatic specific antigen increased 40.91 11.79 9 171536 16916 42432874
Brain injury 40.56 11.79 93 171452 7562 42442228
Manic symptom 40.56 11.79 19 171526 196 42449594
Trichoglossia 40.48 11.79 23 171522 364 42449426
Resting tremor 40.43 11.79 33 171512 968 42448822
Large for dates baby 40.41 11.79 32 171513 898 42448892
Stoma site discharge 40.33 11.79 39 171506 1437 42448353
Status epilepticus 40.13 11.79 146 171399 15432 42434358
Tremor neonatal 40.09 11.79 25 171520 473 42449317
Hypophosphataemia 40.09 11.79 17 171528 20928 42428862
Musculoskeletal pain 40.05 11.79 45 171500 33295 42416495
Electrocardiogram abnormal 39.86 11.79 110 171435 10035 42439755
Neonatal hypoxia 39.84 11.79 26 171519 534 42449256
Squamous cell carcinoma of skin 39.72 11.79 3 171542 12723 42437067
International normalised ratio increased 39.65 11.79 84 171461 48084 42401706
Coordination abnormal 39.60 11.79 95 171450 7955 42441835
Enuresis 39.56 11.79 52 171493 2696 42447094
Tumour lysis syndrome 39.53 11.79 20 171525 22211 42427579
Emotional disorder 39.48 11.79 82 171463 6232 42443558
Dementia with Lewy bodies 39.39 11.79 31 171514 862 42448928
Tachyphrenia 39.28 11.79 38 171507 1401 42448389
Opisthotonus 39.25 11.79 27 171518 607 42449183
COVID-19 pneumonia 39.10 11.79 19 171526 21594 42428196
Jealous delusion 39.09 11.79 23 171522 390 42449400
Blister 38.96 11.79 32 171513 27458 42422332
Alcoholism 38.45 11.79 53 171492 2877 42446913
Overweight 38.43 11.79 48 171497 2364 42447426
Neoplasm malignant 38.19 11.79 22 171523 22721 42427069
Grimacing 38.08 11.79 22 171523 360 42449430
Withdrawal arrhythmia 38.04 11.79 13 171532 52 42449738
Dysgeusia 38.03 11.79 49 171496 34140 42415650
Compartment syndrome 38.01 11.79 56 171489 3233 42446557
Hypoglycaemia neonatal 37.85 11.79 45 171500 2105 42447685
Anxiolytic therapy 37.84 11.79 13 171532 53 42449737
Self-injurious ideation 37.78 11.79 42 171503 1826 42447964
Pulmonary alveolar haemorrhage 37.64 11.79 7 171538 14809 42434981
Tic 37.29 11.79 47 171498 2336 42447454
Wrong patient received product 37.15 11.79 58 171487 3525 42446265
Oropharyngeal spasm 37.10 11.79 18 171527 202 42449588
Lymphadenopathy 36.93 11.79 48 171497 33317 42416473
Pleurothotonus 36.92 11.79 34 171511 1177 42448613
Screaming 36.35 11.79 42 171503 1905 42447885
Paroxysmal perceptual alteration 36.34 11.79 18 171527 212 42449578
Vasoplegia syndrome 36.31 11.79 49 171496 2606 42447184
Eyelid function disorder 36.24 11.79 17 171528 176 42449614
Gastrointestinal disorder 36.23 11.79 84 171461 46569 42403221
Drug therapy enhancement 36.22 11.79 13 171532 62 42449728
Hallucinations, mixed 36.17 11.79 56 171489 3379 42446411
Hypersomnia 35.97 11.79 135 171410 14483 42435307
Device dislocation 35.96 11.79 90 171455 7741 42442049
Sudden death 35.61 11.79 147 171398 16482 42433308
Frequent bowel movements 35.53 11.79 21 171524 21386 42428404
Drug level increased 35.44 11.79 203 171342 25997 42423793
Antisocial behaviour 35.25 11.79 22 171523 417 42449373
Prescription drug used without a prescription 35.25 11.79 49 171496 2681 42447109
Localised infection 35.23 11.79 19 171526 20354 42429436
Gastrointestinal hypomotility 35.02 11.79 34 171511 1259 42448531
Leukopenia 34.98 11.79 457 171088 74289 42375501
Rhinorrhoea 34.92 11.79 46 171499 31748 42418042
Hyperammonaemic encephalopathy 34.86 11.79 49 171496 2709 42447081
Alcohol interaction 34.84 11.79 43 171502 2092 42447698
Galactorrhoea 34.84 11.79 23 171522 482 42449308
Bradypnoea 34.74 11.79 63 171482 4330 42445460
Fungal infection 34.68 11.79 18 171527 19704 42430086
Brain hypoxia 34.50 11.79 25 171520 612 42449178
Bacteraemia 34.44 11.79 30 171515 25010 42424780
Ileus paralytic 34.23 11.79 87 171458 7554 42442236
Parkinsonian gait 34.19 11.79 24 171521 558 42449232
Heart rate decreased 34.18 11.79 59 171486 36473 42413317
Bladder cancer 34.00 11.79 13 171532 17034 42432756
Shock 33.90 11.79 217 171328 28904 42420886
Cytomegalovirus infection reactivation 33.87 11.79 3 171542 11175 42438615
Medication error 33.76 11.79 239 171306 32915 42416875
Inappropriate antidiuretic hormone secretion 33.69 11.79 144 171401 16397 42433393
Clostridium difficile colitis 33.67 11.79 22 171523 21230 42428560
Neonatal seizure 33.67 11.79 23 171522 511 42449279
Product substitution issue 33.59 11.79 111 171434 11179 42438611
Camptocormia 33.58 11.79 16 171529 172 42449618
Vasculitis 33.53 11.79 16 171529 18378 42431412
Dysphonia 33.52 11.79 39 171506 28411 42421379
Blood pressure systolic increased 33.32 11.79 38 171507 27930 42421860
Feelings of worthlessness 33.21 11.79 19 171526 305 42449485
Haematotoxicity 33.15 11.79 3 171542 10982 42438808
Pulmonary mass 33.11 11.79 12 171533 16253 42433537
Autonomic nervous system imbalance 33.09 11.79 51 171494 3065 42446725
Impulse-control disorder 32.87 11.79 36 171509 1539 42448251
Eczema 32.86 11.79 54 171491 34032 42415758
Hangover 32.86 11.79 31 171514 1107 42448683
Libido decreased 32.81 11.79 67 171478 5031 42444759
Staring 32.72 11.79 36 171509 1547 42448243
Hypervolaemia 32.67 11.79 27 171518 23098 42426692
Therapy interrupted 32.67 11.79 25 171520 22225 42427565
Progressive multifocal leukoencephalopathy 32.63 11.79 4 171541 11532 42438258
Acute respiratory failure 32.63 11.79 67 171478 38791 42410999
Electrocardiogram QT interval abnormal 32.58 11.79 13 171532 87 42449703
Congenital nystagmus 32.58 11.79 13 171532 87 42449703
Brachial plexopathy 32.49 11.79 12 171533 63 42449727
Neonatal toxicity 32.49 11.79 10 171535 26 42449764
Dyspepsia 32.48 11.79 74 171471 41278 42408512
Coagulopathy 32.41 11.79 25 171520 22137 42427653
Laboratory test abnormal 32.25 11.79 27 171518 22951 42426839
Embolism venous 32.09 11.79 39 171506 1867 42447923
Delusional disorder, unspecified type 32.08 11.79 26 171519 755 42449035
Rash maculo-papular 32.05 11.79 64 171481 37439 42412351
Bradycardia neonatal 32.01 11.79 33 171512 1315 42448475
Bipolar I disorder 31.98 11.79 27 171518 831 42448959
Cholestasis 31.78 11.79 52 171493 32827 42416963
Pyromania 31.70 11.79 10 171535 29 42449761
Antipsychotic drug level decreased 31.62 11.79 31 171514 1162 42448628
Leukaemia 31.56 11.79 71 171474 5701 42444089
Basal cell carcinoma 31.56 11.79 27 171518 22706 42427084
Mood altered 31.55 11.79 105 171440 10613 42439177
Lung neoplasm malignant 31.47 11.79 19 171526 19128 42430662
Labelled drug-food interaction issue 31.45 11.79 12 171533 70 42449720
Myasthenia gravis 31.05 11.79 13 171532 16124 42433666
Ataxia 31.02 11.79 138 171407 15987 42433803
Hypercalcaemia 30.99 11.79 17 171528 18041 42431749
Urine alcohol test positive 30.90 11.79 11 171534 51 42449739
Gynaecomastia 30.88 11.79 116 171429 12451 42437339
Renal disorder 30.75 11.79 43 171502 28937 42420853
Illness anxiety disorder 30.71 11.79 15 171530 171 42449619
Negativism 30.63 11.79 20 171525 411 42449379
Hypersexuality 30.59 11.79 36 171509 1666 42448124
Bronchitis 30.57 11.79 93 171452 47108 42402682
Dysphemia 30.54 11.79 38 171507 1864 42447926
Hepatitis 30.50 11.79 39 171506 27261 42422529
Inflammation 30.47 11.79 56 171489 33791 42415999
Exposure via ingestion 30.31 11.79 40 171505 2082 42447708
Anaphylactic shock 30.19 11.79 30 171515 23487 42426303
Skin lesion 30.17 11.79 39 171506 27135 42422655
Upper gastrointestinal haemorrhage 30.15 11.79 47 171498 30252 42419538
Amnesia 30.14 11.79 207 171338 28230 42421560
Erectile dysfunction 29.84 11.79 187 171358 24726 42425064
Shock haemorrhagic 29.81 11.79 14 171531 16228 42433562
Oral discharge 29.51 11.79 14 171531 149 42449641
Bronchiectasis 29.45 11.79 18 171527 18001 42431789
Hallucination, tactile 29.42 11.79 22 171523 566 42449224
Excessive masturbation 29.29 11.79 13 171532 117 42449673
Hepatic failure 29.27 11.79 69 171476 38031 42411759
Psoriasis 29.23 11.79 99 171446 48505 42401285
Treatment failure 29.19 11.79 141 171404 62483 42387307
Muscle twitching 29.16 11.79 109 171436 11671 42438119
Wrong drug 29.10 11.79 14 171531 154 42449636
Dissociative disorder 28.94 11.79 23 171522 649 42449141
Dacryostenosis congenital 28.88 11.79 10 171535 42 42449748
Accidental overdose 28.72 11.79 204 171341 28126 42421664
Liver function test increased 28.69 11.79 23 171522 19975 42429815
Cerebellar atrophy 28.56 11.79 24 171521 734 42449056
Oscillopsia 28.51 11.79 16 171529 247 42449543
Lymphoma 28.43 11.79 11 171534 14310 42435480
Acute psychosis 28.39 11.79 39 171506 2110 42447680
Cytomegalovirus viraemia 28.39 11.79 4 171541 10373 42439417
Metastases to bone 28.38 11.79 12 171533 14797 42434993
Lymphopenia 28.27 11.79 27 171518 21536 42428254
Dehydration 28.24 11.79 401 171144 141366 42308424
Osteoarthritis 28.17 11.79 34 171511 24371 42425419
Hot flush 28.14 11.79 29 171516 22322 42427468
Intentional medical device removal by patient 28.02 11.79 19 171526 417 42449373
Injection site erythema 28.02 11.79 24 171521 20171 42429619
Obsessive thoughts 27.94 11.79 25 171520 833 42448957
Hyperosmolar state 27.94 11.79 20 171525 480 42449310
Schizophreniform disorder 27.90 11.79 11 171534 71 42449719
Motor dysfunction 27.82 11.79 84 171461 8062 42441728
Lymphocyte count decreased 27.81 11.79 43 171502 27766 42422024
Wrong patient 27.79 11.79 22 171523 617 42449173
Metastases to lung 27.77 11.79 6 171539 11418 42438372
Renal tubular necrosis 27.75 11.79 20 171525 18334 42431456
Maternal exposure during pregnancy 27.75 11.79 76 171469 6902 42442888
Neck pain 27.60 11.79 49 171496 29965 42419825
Fear 27.60 11.79 102 171443 10863 42438927
Muscle spasms 27.46 11.79 218 171327 85826 42363964
Diffuse large B-cell lymphoma 27.43 11.79 3 171542 9451 42440339
Necrotising colitis 27.42 11.79 30 171515 1281 42448509
Blunted affect 27.19 11.79 18 171527 379 42449411
Pulmonary hypertension 27.03 11.79 33 171512 23536 42426254
Pneumothorax 26.96 11.79 33 171512 23510 42426280
Lower respiratory tract infection 26.82 11.79 81 171464 41125 42408665
Product storage error 26.77 11.79 6 171539 11134 42438656
Respiratory failure 26.75 11.79 359 171186 127773 42322017
Staphylococcal infection 26.71 11.79 71 171474 37572 42412218
Refusal of treatment by patient 26.63 11.79 63 171482 5228 42444562
Blood lactic acid increased 26.62 11.79 82 171463 7957 42441833
Rebound psychosis 26.59 11.79 14 171531 189 42449601
Maternal drugs affecting foetus 26.56 11.79 52 171493 3787 42446003
Neonatal asphyxia 26.51 11.79 19 171526 457 42449333
Cholelithiasis 26.44 11.79 33 171512 23313 42426477
Suture rupture 26.44 11.79 19 171526 459 42449331
Hypoalbuminaemia 26.35 11.79 15 171530 15595 42434195
Blood urea increased 26.31 11.79 58 171487 32735 42417055
Nicotine dependence 26.23 11.79 22 171523 671 42449119
Hypocalcaemia 26.21 11.79 51 171494 30122 42419668
Nervousness 26.18 11.79 116 171429 13416 42436374
Non-cardiogenic pulmonary oedema 26.10 11.79 25 171520 910 42448880
Dependence 26.09 11.79 31 171514 1449 42448341
Stoma site hypergranulation 26.04 11.79 15 171530 244 42449546
Peritonitis 26.02 11.79 22 171523 18611 42431179
Lactic acidosis 26.00 11.79 94 171451 45167 42404623
Accidental poisoning 25.97 11.79 29 171516 1267 42448523
Drug use disorder 25.90 11.79 96 171449 10237 42439553
Atrial flutter 25.82 11.79 19 171526 17232 42432558
Gaze palsy 25.81 11.79 35 171510 1870 42447920
Incontinence 25.79 11.79 73 171472 6757 42443033
Osteonecrosis 25.72 11.79 16 171529 15849 42433941
Bone pain 25.54 11.79 35 171510 23757 42426033
Acute coronary syndrome 25.50 11.79 14 171531 14851 42434939
Neonatal respiratory distress 25.44 11.79 25 171520 940 42448850
Stoma site pain 25.37 11.79 23 171522 780 42449010
Congenital hydrocephalus 25.33 11.79 13 171532 166 42449624
Alcohol use 25.32 11.79 43 171502 2805 42446985
Toxic leukoencephalopathy 25.31 11.79 22 171523 705 42449085
Cytopenia 25.26 11.79 20 171525 17477 42432313
Patent ductus arteriosus 25.17 11.79 48 171497 3428 42446362
Tachycardia foetal 25.07 11.79 17 171528 373 42449417
Encephalopathy neonatal 25.06 11.79 9 171536 43 42449747
Osteomyelitis 24.86 11.79 22 171523 18201 42431589
Affective disorder 24.79 11.79 66 171479 5894 42443896
Hyperdynamic left ventricle 24.76 11.79 15 171530 269 42449521
Myalgia 24.75 11.79 257 171288 95823 42353967
Colitis ulcerative 24.74 11.79 42 171503 26133 42423657
Inappropriate affect 24.57 11.79 22 171523 734 42449056
Stoma site inflammation 24.56 11.79 19 171526 515 42449275
Polydipsia 24.31 11.79 55 171490 4433 42445357
Choreoathetosis 24.28 11.79 26 171519 1083 42448707
Discomfort 24.27 11.79 40 171505 25179 42424611
Oromandibular dystonia 24.24 11.79 20 171525 596 42449194
Food interaction 24.23 11.79 25 171520 997 42448793
Hyperphosphataemia 24.19 11.79 11 171534 12993 42436797
Squamous cell carcinoma 24.12 11.79 11 171534 12971 42436819
Angioedema 23.88 11.79 89 171456 42388 42407402
Gastric infection 23.88 11.79 30 171515 1486 42448304
Venoocclusive liver disease 23.87 11.79 6 171539 10296 42439494
Stoma site infection 23.85 11.79 24 171521 929 42448861
Crying 23.81 11.79 68 171477 6326 42443464
End stage renal disease 23.81 11.79 19 171526 16539 42433251
Drug level below therapeutic 23.79 11.79 69 171476 6476 42443314
Oesophageal carcinoma 23.76 11.79 5 171540 9691 42440099
Injection site swelling 23.75 11.79 20 171525 16953 42432837
Initial insomnia 23.65 11.79 51 171494 3979 42445811
Psychotic disorder due to a general medical condition 23.54 11.79 10 171535 80 42449710
Cerebral infarction 23.50 11.79 57 171488 31112 42418678
Proteinuria 23.50 11.79 35 171510 22948 42426842
Toxic epidermal necrolysis 23.42 11.79 45 171500 26705 42423085
Influenza like illness 23.40 11.79 59 171486 31781 42418009
Mental status changes 23.39 11.79 266 171279 41849 42407941
Feeling guilty 23.32 11.79 16 171529 358 42449432
Embedded device 23.15 11.79 17 171528 425 42449365
Hyperphagia 23.11 11.79 31 171514 1639 42448151
Meconium aspiration syndrome 23.11 11.79 9 171536 56 42449734
Swollen tongue 23.03 11.79 31 171514 21200 42428590
Visceral pain 23.02 11.79 10 171535 85 42449705
Pancreatitis 23.02 11.79 271 171274 42997 42406793
Neutropenia 22.93 11.79 619 170926 198812 42250978
Fluid retention 22.92 11.79 59 171486 31560 42418230
Self-destructive behaviour 22.90 11.79 16 171529 369 42449421
Diastolic hypotension 22.81 11.79 13 171532 207 42449583
Orthostatic hypotension 22.71 11.79 205 171340 30365 42419425
Nodule 22.70 11.79 11 171534 12523 42437267
Knee arthroplasty 22.63 11.79 4 171541 8777 42441013
Neonatal neuroblastoma 22.60 11.79 5 171540 0 42449790
Lip swelling 22.57 11.79 26 171519 19027 42430763
Encephalitis toxic 22.54 11.79 14 171531 263 42449527
Choking 22.51 11.79 66 171479 6232 42443558
Dizziness 22.48 11.79 799 170746 248455 42201335
Distractibility 22.48 11.79 17 171528 445 42449345
Conjunctivitis 22.47 11.79 12 171533 12927 42436863
Skin cancer 22.43 11.79 9 171536 11453 42438337
Hepatotoxicity 22.33 11.79 42 171503 25125 42424665
Synovitis 22.21 11.79 18 171527 15549 42434241
Metastases to central nervous system 22.19 11.79 7 171538 10348 42439442
Blood uric acid increased 22.15 11.79 18 171527 15529 42434261
Inappropriate schedule of product administration 22.13 11.79 263 171282 95639 42354151
Abdominal pain upper 22.09 11.79 219 171326 82390 42367400
Acute generalised exanthematous pustulosis 21.97 11.79 4 171541 8591 42441199
Metastases to liver 21.93 11.79 20 171525 16306 42433484
Developmental delay 21.89 11.79 43 171502 3139 42446651
Epstein-Barr virus infection 21.87 11.79 6 171539 9712 42440078
Patient isolation 21.82 11.79 8 171537 41 42449749
Gastrointestinal necrosis 21.71 11.79 50 171495 4078 42445712
Cholangitis 21.69 11.79 8 171537 10719 42439071
Water intoxication 21.65 11.79 16 171529 404 42449386
Hypoacusis 21.64 11.79 26 171519 18676 42431114
Verbal abuse 21.51 11.79 13 171532 232 42449558
Faeces discoloured 21.51 11.79 22 171523 16992 42432798
Blepharospasm 21.44 11.79 27 171518 1341 42448449
Haemolysis 21.43 11.79 6 171539 9583 42440207
Memory impairment 21.41 11.79 302 171243 49920 42399870
Amblyopia 21.33 11.79 11 171534 142 42449648
Finnegan score increased 21.32 11.79 7 171538 24 42449766
Emotional distress 21.31 11.79 124 171421 15969 42433821
Mood swings 21.29 11.79 81 171464 8745 42441045
Dysphagia 21.26 11.79 411 171134 72308 42377482
Blood phosphorus increased 21.19 11.79 12 171533 12513 42437277
Iron deficiency 21.13 11.79 9 171536 11052 42438738
Swelling face 21.08 11.79 50 171495 27504 42422286
Nonspecific reaction 21.07 11.79 29 171516 1572 42448218
White blood cell count decreased 21.02 11.79 315 171230 110081 42339709
Device kink 20.99 11.79 17 171528 493 42449297
Abnormal clotting factor 20.98 11.79 9 171536 74 42449716
Rhinitis 20.96 11.79 11 171534 11966 42437824
Illness 20.91 11.79 43 171502 24887 42424903
Penis injury 20.85 11.79 13 171532 246 42449544
Hyperlactacidaemia 20.84 11.79 52 171493 4464 42445326
Hyperarousal 20.78 11.79 8 171537 48 42449742
Eye pruritus 20.69 11.79 10 171535 11402 42438388
Renal cancer 20.65 11.79 4 171541 8220 42441570
Pulmonary haemorrhage 20.64 11.79 10 171535 11387 42438403
Acetabulum fracture 20.61 11.79 16 171529 436 42449354
Congenital cerebrovascular anomaly 20.57 11.79 6 171539 12 42449778
Communication disorder 20.44 11.79 39 171506 2786 42447004
Social anxiety disorder 20.42 11.79 18 171527 588 42449202
Organising pneumonia 20.38 11.79 3 171542 7529 42442261
Impaired self-care 20.32 11.79 25 171520 1212 42448578
Patient elopement 20.30 11.79 11 171534 158 42449632
Somatic symptom disorder 20.28 11.79 20 171525 755 42449035
Parkinsonian rest tremor 20.26 11.79 14 171531 317 42449473
pH body fluid decreased 20.26 11.79 5 171540 3 42449787
Haemangioma congenital 20.17 11.79 17 171528 522 42449268
Adrenal insufficiency 20.15 11.79 28 171517 18896 42430894
Pulmonary toxicity 20.13 11.79 5 171540 8650 42441140
Posturing 20.06 11.79 17 171528 526 42449264
Salmonella bacteraemia 20.02 11.79 16 171529 455 42449335
Hepatic encephalopathy 19.95 11.79 22 171523 16420 42433370
Drug intolerance 19.95 11.79 217 171328 80207 42369583
Pulmonary arterial hypertension 19.93 11.79 8 171537 10179 42439611
No adverse event 19.88 11.79 85 171460 38936 42410854
Sciatica 19.82 11.79 3 171542 7374 42442416
Ageusia 19.81 11.79 11 171534 11594 42438196
Stress 19.76 11.79 101 171444 44111 42405679
Troponin increased 19.75 11.79 138 171407 18924 42430866
Respiratory symptom 19.73 11.79 10 171535 11096 42438694
Rebound effect 19.72 11.79 70 171475 7309 42442481
Enterococcal infection 19.71 11.79 12 171533 12027 42437763
Anaemia neonatal 19.69 11.79 15 171530 397 42449393
Abscess 19.68 11.79 17 171528 14231 42435559
Newborn persistent pulmonary hypertension 19.67 11.79 10 171535 125 42449665
Cystitis haemorrhagic 19.64 11.79 3 171542 7326 42442464
Drug diversion 19.63 11.79 22 171523 965 42448825
Gingival pain 19.58 11.79 5 171540 8489 42441301
Normochromic normocytic anaemia 19.54 11.79 6 171539 9025 42440765
Tooth disorder 19.53 11.79 12 171533 11967 42437823
Hepatic cancer 19.53 11.79 5 171540 8475 42441315
Viral infection 19.53 11.79 38 171507 22445 42427345
Impaired quality of life 19.48 11.79 17 171528 14160 42435630
Ejection fraction decreased 19.47 11.79 37 171508 22050 42427740
Flashback 19.46 11.79 10 171535 128 42449662
Toxic skin eruption 19.43 11.79 16 171529 13714 42436076
Guillain-Barre syndrome 19.41 11.79 3 171542 7260 42442530
Junctional ectopic tachycardia 19.39 11.79 6 171539 16 42449774
Pressure of speech 19.37 11.79 17 171528 552 42449238
Eye pain 19.36 11.79 24 171521 17006 42432784
Delusional perception 19.26 11.79 11 171534 176 42449614
Homicide 19.24 11.79 21 171524 894 42448896
Device malfunction 19.21 11.79 13 171532 12314 42437476
Skin disorder 19.14 11.79 24 171521 16920 42432870
Penoscrotal fusion 19.12 11.79 6 171539 17 42449773
Substance use 19.07 11.79 29 171516 1722 42448068
Epidermolysis bullosa 19.06 11.79 10 171535 134 42449656
Injection site pruritus 19.04 11.79 7 171538 9398 42440392
False positive investigation result 19.03 11.79 18 171527 645 42449145
Attention deficit hyperactivity disorder 19.01 11.79 40 171505 3068 42446722
Apraxia 19.00 11.79 27 171518 1508 42448282
Disorganised speech 18.99 11.79 26 171519 1402 42448388
Oral candidiasis 18.93 11.79 18 171527 14387 42435403
Erection increased 18.88 11.79 16 171529 495 42449295
Circulatory failure neonatal 18.87 11.79 6 171539 18 42449772
IVth nerve disorder 18.87 11.79 6 171539 18 42449772
Eye movement disorder 18.82 11.79 53 171492 4892 42444898
SARS-CoV-2 test positive 18.78 11.79 5 171540 8255 42441535
Transient ischaemic attack 18.77 11.79 71 171474 33668 42416122
Drug dispensed to wrong patient 18.72 11.79 16 171529 501 42449289
Dry eye 18.54 11.79 21 171524 15485 42434305
Nephrotic syndrome 18.49 11.79 6 171539 8712 42441078
Nasal congestion 18.49 11.79 59 171486 29442 42420348
Salivary gland calculus 18.47 11.79 9 171536 102 42449688
Acoustic stimulation tests abnormal 18.42 11.79 8 171537 68 42449722
Waxy flexibility 18.40 11.79 9 171536 103 42449687
Candida infection 18.36 11.79 37 171508 21573 42428217
Fever neonatal 18.19 11.79 10 171535 148 42449642
Melaena 18.19 11.79 87 171458 38659 42411131
Stoma site induration 18.18 11.79 7 171538 42 42449748
Hernia 18.18 11.79 11 171534 11062 42438728
Perseveration 18.17 11.79 9 171536 106 42449684
Food refusal 18.13 11.79 13 171532 313 42449477
Panic disorder 18.13 11.79 24 171521 1253 42448537
Telangiectasia congenital 18.08 11.79 4 171541 0 42449790
Posterior reversible encephalopathy syndrome 18.07 11.79 15 171530 12806 42436984
Pain in jaw 18.05 11.79 19 171526 14483 42435307
Cardiac failure chronic 18.05 11.79 8 171537 9593 42440197
Pemphigoid 17.99 11.79 12 171533 11455 42438335
Hallucination, olfactory 17.91 11.79 12 171533 258 42449532
Transfusion 17.89 11.79 10 171535 10504 42439286
Cardiac arrest 17.86 11.79 571 170974 108749 42341041
Acute graft versus host disease in skin 17.84 11.79 4 171541 7420 42442370
Slow response to stimuli 17.84 11.79 21 171524 972 42448818
Anion gap increased 17.81 11.79 31 171514 2063 42447727
Delirium febrile 17.76 11.79 6 171539 23 42449767
Brachial plexus injury 17.74 11.79 8 171537 75 42449715
Negative thoughts 17.73 11.79 18 171527 704 42449086
Language disorder 17.70 11.79 34 171511 2441 42447349
Ocular hyperaemia 17.63 11.79 23 171522 15940 42433850
Fistula 17.59 11.79 5 171540 7907 42441883
Hyperhidrosis 17.57 11.79 483 171062 90029 42359761
Kidney duplex 17.56 11.79 14 171531 397 42449393
Enterocolitis 17.55 11.79 9 171536 9920 42439870
Red blood cell sedimentation rate increased 17.53 11.79 9 171536 9915 42439875
Distributive shock 17.50 11.79 34 171511 2462 42447328
Blood osmolarity decreased 17.46 11.79 17 171528 632 42449158
Drug level decreased 17.43 11.79 83 171462 9894 42439896
Long QT syndrome 17.36 11.79 39 171506 3128 42446662
Tinnitus 17.36 11.79 59 171486 28879 42420911
Foaming at mouth 17.32 11.79 21 171524 1003 42448787
Urinary tract infection 17.32 11.79 288 171257 98996 42350794
Heart disease congenital 17.31 11.79 25 171520 1417 42448373
Painful erection 17.27 11.79 13 171532 338 42449452
Cryptorchism 17.22 11.79 30 171515 1997 42447793
Hypernatraemia 17.19 11.79 83 171462 9949 42439841
Ketoacidosis 17.17 11.79 54 171491 5298 42444492
Post procedural haemorrhage 17.13 11.79 8 171537 9304 42440486
Mouth ulceration 17.10 11.79 21 171524 14942 42434848
Nephrogenic diabetes insipidus 17.05 11.79 26 171519 1548 42448242
Subgaleal haematoma 17.04 11.79 8 171537 83 42449707
Deep vein thrombosis 17.01 11.79 213 171332 76744 42373046
Rash macular 17.00 11.79 26 171519 16865 42432925
Flat affect 16.94 11.79 21 171524 1026 42448764
Pneumonia bacterial 16.93 11.79 23 171522 15669 42434121
Multiple cardiac defects 16.92 11.79 7 171538 52 42449738
Surgery 16.89 11.79 28 171517 17588 42432202
Subarachnoid haemorrhage 16.87 11.79 20 171525 14452 42435338
Gastroenteritis 16.86 11.79 25 171520 16424 42433366
Injection site bruising 16.85 11.79 13 171532 11512 42438278
Psychotic behaviour 16.85 11.79 20 171525 934 42448856
Bundle branch block right 16.84 11.79 71 171474 8035 42441755
Gait disturbance 16.83 11.79 515 171030 97485 42352305
Intercepted medication error 16.81 11.79 15 171530 498 42449292
Polymerase chain reaction 16.79 11.79 8 171537 86 42449704
Convulsive threshold lowered 16.76 11.79 15 171530 500 42449290
Immune reconstitution inflammatory syndrome 16.76 11.79 10 171535 10133 42439657
Borderline personality disorder 16.75 11.79 14 171531 425 42449365
Visual acuity reduced 16.73 11.79 28 171517 17522 42432268
Sputum discoloured 16.73 11.79 10 171535 10122 42439668
Polyneuropathy 16.68 11.79 31 171514 18630 42431160
Angina unstable 16.63 11.79 13 171532 11435 42438355
Postoperative respiratory failure 16.62 11.79 9 171536 129 42449661
Postmortem blood drug level increased 16.61 11.79 15 171530 506 42449284
Pyramidal tract syndrome 16.55 11.79 12 171533 294 42449496
Faecalith 16.53 11.79 5 171540 12 42449778
Tri-iodothyronine decreased 16.50 11.79 9 171536 131 42449659
Compulsions 16.48 11.79 11 171534 235 42449555
Hanging 16.43 11.79 10 171535 181 42449609
Vascular stenosis 16.43 11.79 10 171535 181 42449609
Iatrogenic injury 16.42 11.79 19 171526 863 42448927
Liver disorder 16.37 11.79 93 171452 39551 42410239
Talipes 16.34 11.79 31 171514 2205 42447585
Benign prostatic hyperplasia 16.27 11.79 38 171507 21014 42428776
Oral pain 16.25 11.79 16 171529 12580 42437210
Hiccups 16.24 11.79 15 171530 12156 42437634
Delusion of reference 16.17 11.79 8 171537 94 42449696
Sexual abuse 16.09 11.79 9 171536 138 42449652
Transposition of the great vessels 16.04 11.79 14 171531 451 42449339
Blood pressure fluctuation 16.04 11.79 55 171490 26853 42422937
Arteriosclerosis 15.98 11.79 30 171515 17959 42431831
Hostility 15.96 11.79 18 171527 795 42448995
Immunosuppression 15.96 11.79 7 171538 8446 42441344
Pyelonephritis 15.84 11.79 6 171539 7908 42441882
Growth hormone deficiency 15.81 11.79 12 171533 316 42449474
Migraine 15.80 11.79 51 171494 25363 42424427
Pharyngeal dystonia 15.77 11.79 7 171538 63 42449727
Neutrophil count decreased 15.77 11.79 171 171374 63244 42386546
Bacterial parotitis 15.73 11.79 6 171539 35 42449755
Dermatitis atopic 15.72 11.79 16 171529 12388 42437402
Ear infection 15.68 11.79 17 171528 12787 42437003
Pupillary reflex impaired 15.68 11.79 26 171519 1663 42448127
Haemorrhoids 15.64 11.79 28 171517 17069 42432721
Anal abscess 15.63 11.79 6 171539 7844 42441946
Mutism 15.62 11.79 24 171521 1438 42448352
Binge eating 15.59 11.79 9 171536 147 42449643
Kidney infection 15.58 11.79 4 171541 6766 42443024
Alanine aminotransferase increased 15.56 11.79 256 171289 88150 42361640
Intervertebral disc protrusion 15.55 11.79 13 171532 11059 42438731
Therapeutic product effect decreased 15.55 11.79 93 171452 39057 42410733
Hyperpyrexia 15.54 11.79 40 171505 3500 42446290
Postural orthostatic tachycardia syndrome 15.54 11.79 9 171536 148 42449642
Large intestine polyp 15.50 11.79 9 171536 9256 42440534
Penile haemorrhage 15.50 11.79 20 171525 1018 42448772
Infant irritability 15.49 11.79 7 171538 66 42449724
Self-medication 15.49 11.79 38 171507 3228 42446562
Syndactyly 15.46 11.79 19 171526 920 42448870
Optic discs blurred 15.40 11.79 7 171538 67 42449723
Cataract 15.39 11.79 67 171478 30537 42419253
Colon cancer 15.37 11.79 10 171535 9671 42440119
Laryngeal dyspnoea 15.33 11.79 8 171537 106 42449684
Phaeochromocytoma malignant 15.31 11.79 7 171538 68 42449722
Multiple sclerosis relapse 15.30 11.79 21 171524 14243 42435547
Rales 15.27 11.79 14 171531 11386 42438404
Lung consolidation 15.26 11.79 4 171541 6673 42443117
Myelocyte count increased 15.24 11.79 13 171532 406 42449384
Cytotoxic oedema 15.21 11.79 10 171535 208 42449582
Facial spasm 15.21 11.79 10 171535 208 42449582
Patient uncooperative 15.17 11.79 16 171529 655 42449135
Asocial behaviour 15.13 11.79 7 171538 70 42449720
Apgar score low 15.05 11.79 19 171526 946 42448844
Respiratory syncytial virus infection 15.04 11.79 5 171540 7147 42442643
Injection site haemorrhage 15.03 11.79 15 171530 11721 42438069
Blood urine present 15.02 11.79 15 171530 11718 42438072
Carbon monoxide poisoning 15.00 11.79 8 171537 111 42449679
Endocarditis 15.00 11.79 7 171538 8145 42441645
Cerebral amyloid angiopathy 14.98 11.79 11 171534 275 42449515
Graft versus host disease 14.92 11.79 18 171527 12907 42436883
Forced expiratory volume decreased 14.92 11.79 6 171539 7624 42442166
Haematocrit decreased 14.90 11.79 81 171464 34827 42414963
Anomaly of external ear congenital 14.88 11.79 8 171537 113 42449677
Blood alkaline phosphatase increased 14.87 11.79 77 171468 33520 42416270
Pneumonitis chemical 14.84 11.79 11 171534 279 42449511
Enteritis 14.82 11.79 13 171532 10803 42438987
Loss of employment 14.82 11.79 14 171531 501 42449289
Muscle hypertrophy 14.81 11.79 6 171539 42 42449748
Blood pressure diastolic decreased 14.80 11.79 12 171533 10363 42439427
Musculoskeletal chest pain 14.72 11.79 14 171531 11190 42438600
Feminisation acquired 14.69 11.79 6 171539 43 42449747
Tendonitis 14.67 11.79 11 171534 9883 42439907
Blood creatine phosphokinase decreased 14.65 11.79 15 171530 593 42449197
Parkinson's disease 14.55 11.79 22 171523 1300 42448490
Drug dose omission by device 14.49 11.79 3 171542 5883 42443907
Sinus congestion 14.47 11.79 5 171540 6975 42442815
Tongue spasm 14.46 11.79 6 171539 45 42449745
Jaundice neonatal 14.45 11.79 29 171516 2150 42447640
Food craving 14.45 11.79 14 171531 517 42449273
Drug screen false positive 14.45 11.79 18 171527 884 42448906
Sexual activity increased 14.44 11.79 5 171540 21 42449769
Movement disorder 14.41 11.79 105 171440 14593 42435197
Gastrooesophageal reflux disease 14.39 11.79 114 171431 44909 42404881
Retrograde ejaculation 14.36 11.79 14 171531 521 42449269
Intentional product use issue 14.35 11.79 203 171342 71630 42378160
Tenderness 14.34 11.79 9 171536 8874 42440916
Osmotic demyelination syndrome 14.33 11.79 19 171526 993 42448797
Renal injury 14.29 11.79 17 171528 12263 42437527
Corneal reflex decreased 14.26 11.79 9 171536 174 42449616
Peritonitis bacterial 14.25 11.79 5 171540 6910 42442880
Congenital cystic kidney disease 14.24 11.79 13 171532 445 42449345
Compulsive shopping 14.16 11.79 13 171532 448 42449342
Haemorrhage intracranial 14.13 11.79 30 171515 17162 42432628
Vascular dementia 14.12 11.79 14 171531 532 42449258
Uveitis 14.11 11.79 10 171535 9248 42440542
Ulcer 14.10 11.79 28 171517 16413 42433377
Sluggishness 14.09 11.79 41 171504 3855 42445935
Post procedural complication 14.05 11.79 18 171527 12572 42437218
Plasma cell myeloma recurrent 14.04 11.79 3 171542 5754 42444036
Helplessness 14.02 11.79 7 171538 84 42449706
Hyperglycaemia 14.02 11.79 261 171284 45598 42404192
Tuberculosis 14.01 11.79 12 171533 10087 42439703
Peripheral arterial occlusive disease 14.00 11.79 5 171540 6833 42442957
Embolism 13.98 11.79 9 171536 8754 42441036
Alcohol poisoning 13.96 11.79 64 171481 7510 42442280
Cerebral disorder 13.95 11.79 35 171510 3015 42446775
Drug withdrawal headache 13.90 11.79 5 171540 24 42449766
Stoma site extravasation 13.87 11.79 7 171538 86 42449704
Hyperbilirubinaemia 13.83 11.79 40 171505 20595 42429195
Ventricular arrhythmia 13.83 11.79 56 171489 6223 42443567
Immunodeficiency 13.82 11.79 6 171539 7284 42442506
Hyperglycaemic hyperosmolar nonketotic syndrome 13.82 11.79 24 171521 1594 42448196
Intestinal perforation 13.81 11.79 14 171531 10860 42438930
Blood lactate dehydrogenase increased 13.79 11.79 56 171489 26025 42423765
Brain natriuretic peptide increased 13.77 11.79 5 171540 6765 42443025
Hypotonia 13.77 11.79 75 171470 9424 42440366
Type 1 diabetes mellitus 13.77 11.79 51 171494 5436 42444354
Clostridium difficile infection 13.72 11.79 46 171499 22613 42427177
Intermittent explosive disorder 13.72 11.79 4 171541 8 42449782
Scaphocephaly 13.71 11.79 6 171539 52 42449738
Angina pectoris 13.67 11.79 77 171468 32819 42416971
Orthostatic hypertension 13.67 11.79 13 171532 469 42449321
Anhedonia 13.67 11.79 64 171481 7576 42442214
Hepatocellular carcinoma 13.65 11.79 8 171537 8186 42441604
Soft tissue disorder 13.61 11.79 17 171528 837 42448953
Hepatitis B 13.58 11.79 5 171540 6706 42443084
Medical device site injury 13.56 11.79 3 171542 0 42449790
Scrotal irritation 13.56 11.79 3 171542 0 42449790
Hyperresponsive to stimuli 13.56 11.79 3 171542 0 42449790
Alcohol test positive 13.56 11.79 3 171542 0 42449790
Dopamine dysregulation syndrome 13.56 11.79 14 171531 559 42449231
Somatic delusion 13.53 11.79 7 171538 91 42449699
Cyanosis neonatal 13.47 11.79 11 171534 323 42449467
Stevens-Johnson syndrome 13.45 11.79 45 171500 22133 42427657
Bacterial infection 13.44 11.79 62 171483 27817 42421973
Neuroleptic-induced deficit syndrome 13.42 11.79 5 171540 27 42449763
Aplasia pure red cell 13.42 11.79 6 171539 7160 42442630
Cholinergic syndrome 13.42 11.79 15 171530 656 42449134
Eyelid ptosis 13.41 11.79 5 171540 6656 42443134
Depersonalisation/derealisation disorder 13.40 11.79 15 171530 657 42449133
Cardiac disorder 13.38 11.79 129 171416 48803 42400987
Diabetes insipidus 13.36 11.79 39 171506 3674 42446116
Mucormycosis 13.35 11.79 6 171539 7137 42442653
Eosinophilic pleural effusion 13.32 11.79 11 171534 328 42449462
Electrocardiogram change 13.29 11.79 15 171530 663 42449127
Non-high-density lipoprotein cholesterol increased 13.29 11.79 9 171536 197 42449593
Breast inflammation 13.27 11.79 5 171540 28 42449762
Disseminated intravascular coagulation 13.26 11.79 53 171492 24741 42425049
Generalised oedema 13.25 11.79 26 171519 15310 42434480
Blood pressure systolic abnormal 13.24 11.79 3 171542 5525 42444265
Contraindication to medical treatment 13.24 11.79 17 171528 861 42448929
Congenital pulmonary valve atresia 13.24 11.79 6 171539 57 42449733
Myoclonic epilepsy 13.23 11.79 24 171521 1650 42448140
Seasonal allergy 13.23 11.79 8 171537 8047 42441743
Rotator cuff syndrome 13.17 11.79 5 171540 6581 42443209
Antidepressant drug level above therapeutic 13.15 11.79 10 171535 264 42449526
Mixed dementia 13.15 11.79 10 171535 264 42449526
Malnutrition 13.14 11.79 24 171521 14518 42435272
Tobacco interaction 13.14 11.79 7 171538 97 42449693
Emphysema 13.12 11.79 17 171528 11818 42437972
Divorced 13.11 11.79 4 171541 10 42449780
Chorea 13.10 11.79 22 171523 1422 42448368
Open reduction of fracture 13.07 11.79 7 171538 98 42449692
Walking disability 13.07 11.79 20 171525 1194 42448596
Systemic lupus erythematosus 13.03 11.79 11 171534 9313 42440477
Herbal interaction 13.02 11.79 12 171533 416 42449374
Boredom 12.99 11.79 5 171540 30 42449760
Metastases to lymph nodes 12.95 11.79 4 171541 5994 42443796
Gastritis erosive 12.90 11.79 5 171540 6498 42443292
Belligerence 12.89 11.79 8 171537 150 42449640
Ventricular septal defect 12.86 11.79 43 171502 4356 42445434
Haemolytic anaemia 12.86 11.79 18 171527 12109 42437681
Orthopnoea 12.85 11.79 3 171542 5414 42444376
Face oedema 12.85 11.79 22 171523 13644 42436146
Peripheral ischaemia 12.84 11.79 5 171540 6480 42443310
Bacterial sepsis 12.83 11.79 5 171540 6477 42443313
Respiratory acidosis 12.80 11.79 55 171490 6276 42443514
Anamnestic reaction 12.80 11.79 6 171539 62 42449728
Breath sounds abnormal 12.77 11.79 18 171527 12075 42437715
Product dose omission in error 12.76 11.79 9 171536 8345 42441445
Hypopnoea 12.71 11.79 8 171537 7874 42441916
Haemorrhagic stroke 12.66 11.79 7 171538 7395 42442395
Infantile apnoea 12.64 11.79 19 171526 1117 42448673
Sciatic nerve neuropathy 12.63 11.79 6 171539 64 42449726
Obsessive-compulsive personality disorder 12.62 11.79 8 171537 156 42449634
Lung adenocarcinoma 12.58 11.79 3 171542 5336 42444454
Shoulder deformity 12.58 11.79 4 171541 12 42449778
Sleep disorder therapy 12.56 11.79 6 171539 6888 42442902
Pulmonary embolism 12.52 11.79 376 171169 119236 42330554
Nuchal rigidity 12.51 11.79 13 171532 523 42449267
Hypertension 12.44 11.79 548 170997 166656 42283134
Gastroenteritis salmonella 12.41 11.79 15 171530 714 42449076
Leukopenia neonatal 12.34 11.79 4 171541 13 42449777
Ejaculation disorder 12.34 11.79 18 171527 1030 42448760
Eye swelling 12.33 11.79 18 171527 11902 42437888
Mental disability 12.32 11.79 6 171539 68 42449722
Duodenal ulcer haemorrhage 12.32 11.79 4 171541 5804 42443986
Postmortem blood drug level 12.31 11.79 8 171537 163 42449627
Musculoskeletal discomfort 12.27 11.79 12 171533 9464 42440326
Xanthoma 12.25 11.79 7 171538 112 42449678
Troponin I increased 12.25 11.79 34 171511 3112 42446678
Small intestinal obstruction 12.24 11.79 32 171513 17029 42432761
Aortic aneurysm 12.23 11.79 8 171537 7715 42442075
Immune effector cell-associated neurotoxicity syndrome 12.22 11.79 12 171533 9449 42440341
Glabellar reflex abnormal 12.22 11.79 5 171540 36 42449754
Off label use 12.17 11.79 2325 169220 636010 41813780
Oxygen saturation decreased 12.16 11.79 185 171360 64502 42385288
Systemic infection 12.12 11.79 3 171542 5202 42444588
Escherichia sepsis 12.11 11.79 4 171541 5743 42444047
Hyponatraemic coma 12.10 11.79 5 171540 37 42449753
Metamyelocyte count increased 12.10 11.79 12 171533 456 42449334
Respiratory tract congestion 12.09 11.79 8 171537 7670 42442120
Flatulence 12.08 11.79 56 171489 25096 42424694
Exposure via body fluid 12.04 11.79 7 171538 116 42449674
Dependent personality disorder 12.02 11.79 6 171539 72 42449718
Pneumonia salmonella 12.02 11.79 6 171539 72 42449718
Skin infection 12.00 11.79 12 171533 9368 42440422
Hepatomegaly 11.99 11.79 18 171527 11767 42438023
Trifascicular block 11.99 11.79 7 171538 117 42449673
Incorrect route of product administration 11.95 11.79 150 171395 24155 42425635
Hypoxic-ischaemic encephalopathy 11.94 11.79 47 171498 5155 42444635
Hepatic cirrhosis 11.93 11.79 40 171505 19662 42430128
Selective mutism 11.87 11.79 6 171539 74 42449716
Pharyngitis 11.81 11.79 11 171534 8879 42440911

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5956.52 10.70 6283 480116 236098 109866802
Toxicity to various agents 5163.80 10.70 8269 478130 472286 109630614
Suicide attempt 4363.01 10.70 3624 482775 99770 110003130
Sopor 4079.04 10.70 2335 484064 34211 110068689
Intentional overdose 3843.25 10.70 3760 482639 128741 109974159
Neuroleptic malignant syndrome 3445.98 10.70 2042 484357 32017 110070883
Drug abuse 3199.64 10.70 3921 482478 173490 109929410
Overdose 2105.52 10.70 3725 482674 230069 109872831
Intentional self-injury 1980.81 10.70 1500 484899 35929 110066971
Drug interaction 1893.40 10.70 5652 480747 494531 109608369
Coma 1757.08 10.70 2372 484027 115497 109987403
Somnolence 1755.91 10.70 3973 482426 293476 109809424
Sedation 1626.73 10.70 1761 484638 67922 110034978
Dystonia 1497.03 10.70 1093 485306 24712 110078188
Suicidal ideation 1442.02 10.70 1918 484481 92019 110010881
Electrocardiogram QT prolonged 1408.35 10.70 2048 484351 106912 109995988
Agitation 1397.88 10.70 2081 484318 110970 109991930
Extrapyramidal disorder 1330.07 10.70 1066 485333 27801 110075099
Dyskinesia 1321.15 10.70 1368 485031 50078 110052822
Tardive dyskinesia 1210.50 10.70 751 485648 12828 110090072
Depressed level of consciousness 1160.02 10.70 1903 484496 110375 109992525
Parkinsonism 1098.86 10.70 855 485544 21332 110081568
Aggression 1018.06 10.70 1279 485120 57931 110044969
Akathisia 990.65 10.70 724 485675 16389 110086511
Serotonin syndrome 982.58 10.70 1256 485143 57897 110045003
Psychotic disorder 946.19 10.70 1144 485255 49793 110053107
Delusion 819.44 10.70 743 485656 23012 110079888
Mania 802.21 10.70 693 485706 20103 110082797
Muscle rigidity 775.24 10.70 724 485675 23307 110079593
Poisoning deliberate 769.18 10.70 751 485648 25580 110077320
Blood prolactin abnormal 758.85 10.70 360 486039 3475 110099425
Febrile neutropenia 734.26 10.70 239 486160 316528 109786372
Diarrhoea 726.15 10.70 2578 483821 1136927 108965973
Dyspnoea 723.53 10.70 2477 483922 1104395 108998505
Poisoning 722.14 10.70 760 485639 28345 110074555
Sexual dysfunction 710.67 10.70 452 485947 8078 110094822
Schizophrenia 670.48 10.70 640 485759 21186 110081714
Hallucination 661.94 10.70 1412 484987 100020 110002880
Delirium 620.89 10.70 1640 484759 133385 109969515
Hallucination, auditory 608.57 10.70 663 485736 25734 110077166
Cough 602.97 10.70 685 485714 460956 109641944
Anaemia 593.43 10.70 931 485468 546155 109556745
Bradyphrenia 587.34 10.70 455 485944 11273 110091627
Paranoia 586.98 10.70 602 485797 21772 110081128
Catatonia 586.92 10.70 448 485951 10852 110092048
Disease progression 579.94 10.70 176 486223 243858 109859042
Altered state of consciousness 577.79 10.70 964 485435 56662 110046238
Anosognosia 574.69 10.70 304 486095 3770 110099130
Restlessness 571.94 10.70 947 485452 55312 110047588
Bezoar 559.13 10.70 298 486101 3756 110099144
Malignant neoplasm progression 530.64 10.70 70 486329 174497 109928403
Priapism 527.05 10.70 326 486073 5535 110097365
Disturbance in social behaviour 510.63 10.70 303 486096 4755 110098145
Psychomotor hyperactivity 505.73 10.70 531 485868 19746 110083154
Gestational diabetes 486.14 10.70 338 486061 7051 110095849
Tachycardia 483.92 10.70 2128 484271 224517 109878383
Abnormal behaviour 481.26 10.70 718 485681 38321 110064579
Hypomania 474.41 10.70 379 486020 9831 110093069
Prescribed overdose 470.81 10.70 1129 485270 86452 110016448
Arthralgia 463.95 10.70 1812 484587 777820 109325080
Intentional product misuse 454.44 10.70 1452 484947 131452 109971448
Depression 447.04 10.70 2651 483748 314684 109788216
Bradykinesia 443.66 10.70 373 486026 10415 110092485
Suspected suicide 442.96 10.70 433 485966 14766 110088134
Confusional state 442.27 10.70 3548 482851 465132 109637768
Cardio-respiratory arrest 433.52 10.70 1306 485093 114530 109988370
Metabolic disorder 419.11 10.70 357 486042 10153 110092747
Tremor 416.73 10.70 1879 484520 200353 109902547
Respiratory arrest 412.33 10.70 839 485560 57460 110045440
Sepsis 404.48 10.70 507 485892 326839 109776061
Hyperprolactinaemia 396.07 10.70 285 486114 6290 110096610
Nausea 394.08 10.70 3510 482889 1232180 108870720
COVID-19 393.50 10.70 301 486098 244759 109858141
Psychiatric decompensation 389.35 10.70 268 486131 5497 110097403
Anxiety 375.04 10.70 2701 483698 342377 109760523
Fatigue 372.44 10.70 3489 482910 1212469 108890431
Personality change 367.47 10.70 338 486061 10664 110092236
Pneumonia 366.94 10.70 2306 484093 874408 109228492
Blood creatine phosphokinase increased 366.15 10.70 917 485482 72160 110030740
Sinus tachycardia 362.91 10.70 680 485719 43813 110059087
Rhabdomyolysis 357.12 10.70 1254 485145 119147 109983753
Neuropathy peripheral 355.00 10.70 172 486227 179105 109923795
Oculogyric crisis 354.40 10.70 217 486182 3615 110099285
Myelosuppression 350.29 10.70 15 486384 94325 110008575
Back pain 345.32 10.70 694 485705 370302 109732598
Mydriasis 336.03 10.70 450 485949 21707 110081193
Loss of consciousness 330.96 10.70 1722 484677 194584 109908316
Pain 324.77 10.70 2666 483733 952289 109150611
Rash 320.83 10.70 2204 484195 818760 109284140
Disorientation 313.21 10.70 847 485552 69824 110033076
Pruritus 312.44 10.70 1405 484994 580155 109522745
Miosis 301.06 10.70 425 485974 21558 110081342
Psychomotor skills impaired 298.45 10.70 248 486151 6810 110096090
Anticholinergic syndrome 296.23 10.70 202 486197 4078 110098822
Cardiac failure congestive 294.22 10.70 148 486251 150852 109952048
Pain in extremity 293.84 10.70 1125 485274 485993 109616907
Psychomotor retardation 291.10 10.70 255 486144 7537 110095363
Platelet count decreased 290.79 10.70 351 486048 230092 109872808
Galactorrhoea 289.71 10.70 197 486202 3958 110098942
Atrial fibrillation 289.54 10.70 350 486049 229292 109873608
Metabolic syndrome 285.38 10.70 178 486221 3069 110099831
Obsessive-compulsive disorder 284.73 10.70 244 486155 6997 110095903
Hallucination, visual 283.64 10.70 573 485826 39032 110063868
Irritability 282.82 10.70 640 485759 47169 110055731
Herpes zoster 280.36 10.70 66 486333 108313 109994587
Speech disorder 273.93 10.70 739 485660 60830 110042070
Cogwheel rigidity 271.41 10.70 181 486218 3517 110099383
Mucosal inflammation 270.56 10.70 48 486351 96093 110006807
Haemoglobin decreased 264.77 10.70 428 485971 248299 109854601
Stubbornness 257.31 10.70 90 486309 351 110102549
Headache 257.18 10.70 2561 483838 879816 109223084
Acute kidney injury 255.93 10.70 1690 484709 633740 109469160
Seizure 254.53 10.70 1756 484643 219429 109883471
Pancytopenia 252.23 10.70 331 486068 209282 109893618
Thinking abnormal 252.13 10.70 322 486077 14818 110088082
Diabetes mellitus 250.26 10.70 982 485417 98399 110004501
Salivary hypersecretion 247.80 10.70 343 486056 17078 110085822
Obesity 245.30 10.70 1069 485330 112282 109990618
Substance abuse 243.00 10.70 287 486112 12176 110090724
Restless legs syndrome 241.52 10.70 408 485991 24218 110078682
Liver injury 240.84 10.70 1301 485098 149112 109953788
Interstitial lung disease 239.52 10.70 159 486240 139175 109963725
Dysarthria 237.31 10.70 862 485537 83259 110019641
Drug withdrawal syndrome 236.98 10.70 520 485879 37534 110065366
Influenza 228.06 10.70 244 486155 168857 109934043
Chest discomfort 227.68 10.70 257 486142 173591 109929309
Injection site pain 227.64 10.70 268 486131 177654 109925246
Emotional poverty 225.48 10.70 104 486295 936 110101964
Type 2 diabetes mellitus 221.28 10.70 1436 484963 175796 109927104
Disturbance in attention 220.69 10.70 687 485712 61308 110041592
Erythema 219.33 10.70 610 485789 290837 109812063
Depressive symptom 218.17 10.70 225 486174 8189 110094711
Treatment noncompliance 217.05 10.70 761 485638 72229 110030671
Antipsychotic drug level increased 216.00 10.70 206 486193 6809 110096091
Bipolar disorder 215.95 10.70 231 486168 8776 110094124
Apathy 213.62 10.70 308 486091 15931 110086969
Blood prolactin increased 212.87 10.70 171 486228 4471 110098429
Exposure during pregnancy 211.75 10.70 1361 485038 166063 109936837
Urinary retention 211.09 10.70 731 485668 68952 110033948
Gastrointestinal haemorrhage 209.95 10.70 251 486148 165267 109937633
Hyperreflexia 209.54 10.70 233 486166 9252 110093648
Coma scale abnormal 206.45 10.70 234 486165 9492 110093408
Cytokine release syndrome 204.72 10.70 32 486367 70274 110032626
Myoclonus 204.45 10.70 450 485949 32548 110070352
Pyrexia 202.29 10.70 2760 483639 895505 109207395
Schizoaffective disorder 200.58 10.70 141 486258 2995 110099905
Electrocardiogram QRS complex prolonged 198.28 10.70 265 486134 12756 110090144
Colitis 196.76 10.70 102 486297 102221 110000679
Injection site erythema 196.30 10.70 84 486315 94092 110008808
Chills 196.23 10.70 335 486064 190245 109912655
Anaphylactic reaction 195.69 10.70 131 486268 114169 109988731
Epistaxis 193.27 10.70 173 486226 130199 109972701
Myocardial infarction 191.11 10.70 345 486054 191738 109911162
Cellulitis 189.48 10.70 165 486234 125851 109977049
Persecutory delusion 188.52 10.70 182 486217 6109 110096791
Ascites 188.36 10.70 86 486313 92722 110010178
Mental impairment 188.35 10.70 349 486050 22290 110080610
Thrombosis 188.11 10.70 123 486276 108539 109994361
Respiratory depression 186.61 10.70 426 485973 31575 110071325
Urinary tract infection 185.52 10.70 771 485628 325511 109777389
Psychotic symptom 182.77 10.70 145 486254 3722 110099178
Unresponsive to stimuli 182.74 10.70 657 485742 63133 110039767
Depression suicidal 180.47 10.70 158 486241 4666 110098234
Malaise 178.73 10.70 1991 484408 669828 109433072
Pneumonia aspiration 175.65 10.70 766 485633 80467 110022433
Cardiac arrest 175.17 10.70 1471 484928 195282 109907618
Cytomegalovirus infection 174.92 10.70 18 486381 54426 110048474
Tearfulness 174.38 10.70 188 486211 7207 110095693
Skin ulcer 174.31 10.70 34 486365 63611 110039289
Dry skin 173.00 10.70 132 486267 107521 109995379
Hallucinations, mixed 172.50 10.70 202 486197 8491 110094409
Dyspnoea exertional 171.87 10.70 124 486275 103936 109998964
Euphoric mood 171.65 10.70 203 486196 8624 110094276
Rhinorrhoea 170.01 10.70 122 486277 102544 110000356
Neoplasm progression 165.75 10.70 40 486359 64555 110038345
Pleural effusion 165.55 10.70 332 486067 177377 109925523
Productive cough 165.49 10.70 155 486244 114150 109988750
Mental disorder 164.96 10.70 458 485941 38333 110064567
Weight increased 164.45 10.70 2676 483723 416968 109685932
Plasma cell myeloma 161.44 10.70 39 486360 62897 110040003
Flushing 161.30 10.70 134 486265 104602 109998298
Hyperthermia 161.01 10.70 315 486084 20957 110081943
Withdrawal syndrome 159.48 10.70 396 486003 30984 110071916
Anger 159.37 10.70 294 486105 18713 110084187
Product dose omission issue 159.29 10.70 800 485599 320982 109781918
Blood pressure increased 158.65 10.70 592 485807 257781 109845119
Stupor 154.02 10.70 186 486213 8079 110094821
Orthostatic hypertension 153.87 10.70 80 486319 955 110101945
Pneumocystis jirovecii pneumonia 151.64 10.70 9 486390 42726 110060174
Cognitive disorder 148.98 10.70 770 485629 86741 110016159
Drug dependence 147.40 10.70 520 485879 49500 110053400
Depressed mood 146.74 10.70 593 485806 60216 110042684
Disorganised speech 143.71 10.70 118 486281 3185 110099715
Pleurothotonus 143.01 10.70 105 486294 2393 110100507
Myocarditis 142.05 10.70 369 486030 29686 110073214
Dissociation 140.31 10.70 194 486205 9648 110093252
Hypokinesia 140.17 10.70 302 486097 21524 110081376
Thrombocytopenia 139.15 10.70 930 485469 347955 109754945
Injection site reaction 137.11 10.70 114 486285 88956 110013944
Drug screen positive 135.68 10.70 154 486245 6256 110096644
Nasal congestion 135.65 10.70 139 486260 98143 110004757
Derealisation 135.64 10.70 96 486303 2062 110100838
Deep vein thrombosis postoperative 134.26 10.70 567 485832 58724 110044176
Posture abnormal 134.14 10.70 129 486270 4309 110098591
Somnambulism 134.09 10.70 153 486246 6252 110096648
Prescribed underdose 133.67 10.70 605 485794 64569 110038331
Sleep-related eating disorder 133.24 10.70 70 486329 855 110102045
Septic shock 132.88 10.70 311 486088 157217 109945683
Drooling 131.96 10.70 160 486239 6979 110095921
Suicidal behaviour 131.75 10.70 115 486284 3382 110099518
Depersonalisation/derealisation disorder 130.14 10.70 94 486305 2087 110100813
Labour complication 130.06 10.70 41 486358 105 110102795
Myalgia 129.15 10.70 521 485878 221860 109881040
Amnesia 128.42 10.70 849 485550 104559 109998341
Palmar-plantar erythrodysaesthesia syndrome 128.16 10.70 15 486384 41010 110061890
Osteonecrosis of jaw 126.65 10.70 28 486371 47989 110054911
Bone marrow failure 126.42 10.70 48 486351 57800 110045100
Hyperammonaemic encephalopathy 126.13 10.70 137 486262 5297 110097603
Skin exfoliation 125.53 10.70 120 486279 87531 110015369
Bradypnoea 124.07 10.70 171 486228 8478 110094422
Cardiac failure 123.77 10.70 417 485982 187209 109915691
Bone pain 123.63 10.70 66 486333 65067 110037833
Drug hypersensitivity 122.08 10.70 1342 485057 452748 109650152
Pneumonitis 121.49 10.70 95 486304 76436 110026464
Renal impairment 121.47 10.70 423 485976 188022 109914878
Diverticulitis 121.05 10.70 42 486357 53480 110049420
Mood altered 120.72 10.70 281 486118 21094 110081806
Autoimmune disorder 120.49 10.70 589 485810 64894 110038006
Neck pain 119.03 10.70 225 486174 122905 109979995
Aspiration 117.70 10.70 348 486051 30185 110072715
Oropharyngeal pain 117.39 10.70 263 486136 135013 109967887
Haematochezia 117.12 10.70 205 486194 115319 109987581
Abdominal pain 117.05 10.70 1571 484828 511418 109591482
Logorrhoea 116.85 10.70 126 486273 4831 110098069
Weight decreased 116.59 10.70 1407 484992 466650 109636250
Acute myeloid leukaemia 116.44 10.70 15 486384 38095 110064805
Injection site pruritus 116.31 10.70 40 486359 51218 110051682
Renal failure 116.30 10.70 556 485843 226018 109876882
Diabetic coma 115.22 10.70 73 486326 1295 110101605
Cerebrovascular accident 114.13 10.70 411 485988 180873 109922027
Injection site swelling 113.83 10.70 65 486334 61725 110041175
Dementia 113.64 10.70 352 486047 31321 110071579
Generalised tonic-clonic seizure 113.19 10.70 509 485890 54171 110048729
Adjustment disorder with depressed mood 112.37 10.70 436 485963 43447 110059453
Tubulointerstitial nephritis 112.19 10.70 49 486350 54235 110048665
White blood cell count decreased 111.37 10.70 574 485825 228816 109874084
On and off phenomenon 110.57 10.70 116 486283 4308 110098592
Substance use disorder 110.44 10.70 148 486251 7142 110095758
Coronary artery disease 110.04 10.70 92 486307 71598 110031302
Full blood count abnormal 109.06 10.70 55 486344 55997 110046903
Bipolar I disorder 108.75 10.70 86 486313 2197 110100703
Antipsychotic drug level below therapeutic 108.63 10.70 77 486322 1658 110101242
Nephrolithiasis 107.90 10.70 80 486319 66132 110036768
Hyperkalaemia 107.54 10.70 277 486122 135519 109967381
Abdominal distension 106.93 10.70 402 485997 174701 109928199
Swollen joint count increased 106.89 10.70 682 485717 82979 110019921
Bronchopulmonary aspergillosis 106.85 10.70 6 486393 29857 110073043
Lower limb fracture 106.20 10.70 630 485769 74718 110028182
Anaphylactic shock 105.79 10.70 47 486352 51499 110051401
Impulse-control disorder 105.26 10.70 83 486316 2111 110100789
Asthenia 104.87 10.70 2271 484128 686728 109416172
Memory impairment 104.18 10.70 1324 485075 195620 109907280
Disinhibition 104.11 10.70 96 486303 3038 110099862
Bronchitis 103.56 10.70 349 486050 156683 109946217
Homicidal ideation 103.21 10.70 102 486297 3525 110099375
Feeling of despair 102.90 10.70 104 486295 3694 110099206
Hypothermia 102.55 10.70 301 486098 26001 110076899
Social avoidant behaviour 101.97 10.70 122 486277 5247 110097653
Mood swings 101.63 10.70 274 486125 22538 110080362
Myelodysplastic syndrome 100.61 10.70 21 486378 37463 110065437
Malignant catatonia 100.48 10.70 53 486346 653 110102247
Blood cholesterol increased 98.91 10.70 1245 485154 183540 109919360
Aspergillus infection 98.80 10.70 3 486396 25613 110077287
Clonus 98.50 10.70 154 486245 8562 110094338
Foetal death 98.47 10.70 218 486181 15827 110087073
Inappropriate schedule of product administration 98.04 10.70 511 485888 203126 109899774
Angioedema 97.86 10.70 177 486222 98323 110004577
Haematuria 97.83 10.70 133 486266 82872 110020028
Nasopharyngitis 97.59 10.70 1187 485212 393174 109709726
Behaviour disorder 97.48 10.70 162 486237 9485 110093415
Dysphonia 97.48 10.70 114 486285 75815 110027085
Alcohol abuse 96.91 10.70 114 486285 4815 110098085
Neutropenic sepsis 96.65 10.70 11 486388 30735 110072165
Chronic sinusitis 96.52 10.70 3 486396 25081 110077819
Self-injurious ideation 96.42 10.70 107 486292 4239 110098661
Hyperkinesia 95.20 10.70 92 486307 3092 110099808
Faecaloma 94.27 10.70 205 486194 14703 110088197
Hypervolaemia 94.05 10.70 50 486349 49410 110053490
Accidental death 93.79 10.70 113 486286 4896 110098004
Lupus vulgaris 93.67 10.70 345 486054 33538 110069362
Dehydration 93.34 10.70 783 485616 278728 109824172
Akinesia 93.17 10.70 97 486302 3570 110099330
Myoglobin urine present 92.57 10.70 55 486344 865 110102035
Eczema 92.31 10.70 109 486290 72184 110030716
Haemorrhage 92.10 10.70 208 486191 106484 109996416
Peripheral swelling 91.50 10.70 1239 485160 402795 109700105
Clostridium difficile colitis 91.30 10.70 39 486360 43739 110059161
Major depression 91.21 10.70 166 486233 10455 110092445
Basal cell carcinoma 90.23 10.70 43 486356 45227 110057673
Medication error 90.16 10.70 781 485618 104585 109998315
Sinusitis 89.91 10.70 852 485547 295836 109807064
Dysgeusia 88.85 10.70 106 486293 69879 110033021
Hypotension 88.84 10.70 2971 483428 520878 109582022
Localised infection 88.74 10.70 39 486360 43009 110059891
Acute myocardial infarction 88.29 10.70 145 486254 83632 110019268
Transplant rejection 87.70 10.70 5 486394 24562 110078338
Neutropenia 87.30 10.70 1142 485257 373478 109729422
Alcohol interaction 87.26 10.70 94 486305 3600 110099300
Colitis ischaemic 87.06 10.70 221 486178 17529 110085371
Therapy interrupted 86.76 10.70 56 486343 49766 110053134
Drug use disorder 86.54 10.70 223 486176 17851 110085049
Blood pressure systolic increased 86.20 10.70 145 486254 82846 110020054
Tension 86.13 10.70 109 486290 4969 110097931
Temperature regulation disorder 85.28 10.70 180 486219 12646 110090254
Arthritis 84.96 10.70 413 485986 167173 109935727
Dislocation of vertebra 83.85 10.70 398 486001 43323 110059577
Injection site bruising 83.45 10.70 62 486337 51201 110051699
Metastases to bone 83.34 10.70 18 486381 31354 110071546
Rash pruritic 83.18 10.70 193 486206 97876 110005024
Polydipsia 82.97 10.70 133 486266 7555 110095345
Long QT syndrome 82.16 10.70 127 486272 6991 110095909
Pulmonary hypertension 82.15 10.70 73 486326 55147 110047753
Gastric pH decreased 81.89 10.70 53 486346 977 110101923
Sinus congestion 81.89 10.70 17 486382 30442 110072458
Apraxia 81.73 10.70 89 486310 3451 110099449
Hypomagnesaemia 81.48 10.70 87 486312 60283 110042617
Accidental poisoning 80.33 10.70 75 486324 2412 110100488
Full blood count decreased 80.18 10.70 21 486378 32078 110070822
Exposure via ingestion 79.68 10.70 103 486296 4797 110098103
Rheumatoid factor positive 79.67 10.70 908 485491 130732 109972168
Device expulsion 79.50 10.70 19 486380 30872 110072028
Impulsive behaviour 79.44 10.70 85 486314 3230 110099670
Viral infection 79.35 10.70 70 486329 53069 110049831
Enuresis 79.32 10.70 94 486305 4002 110098898
Tumour lysis syndrome 79.16 10.70 19 486380 30782 110072118
Hypercalcaemia 79.14 10.70 54 486345 46603 110056297
Psychiatric symptom 79.12 10.70 144 486255 9069 110093831
Bacteraemia 78.93 10.70 44 486355 42346 110060554
Hot flush 78.65 10.70 105 486294 65931 110036969
Macular degeneration 78.59 10.70 4 486395 21655 110081245
Fungal infection 78.22 10.70 65 486334 50741 110052159
Pseudomonas infection 78.15 10.70 14 486385 27839 110075061
Visceral congestion 78.05 10.70 57 486342 1288 110101612
Torticollis 77.91 10.70 83 486316 3138 110099762
Onychomycosis 77.72 10.70 36 486363 38495 110064405
Head titubation 77.60 10.70 57 486342 1300 110101600
Gout 77.18 10.70 32 486367 36534 110066366
Joint swelling 77.09 10.70 1427 484972 441418 109661482
Throat irritation 77.05 10.70 73 486326 53479 110049421
Peripheral venous disease 77.00 10.70 633 485766 83484 110019416
Sinus disorder 76.97 10.70 24 486375 32704 110070196
Pain in jaw 76.92 10.70 67 486332 51110 110051790
Procedural pain 76.90 10.70 30 486369 35535 110067365
Device related infection 76.55 10.70 39 486360 39480 110063420
Amenorrhoea 76.40 10.70 142 486257 9089 110093811
Breast cancer 76.22 10.70 37 486362 38505 110064395
Oromandibular dystonia 76.09 10.70 54 486345 1165 110101735
Metastases to lung 75.73 10.70 7 486392 23056 110079844
Oral candidiasis 75.66 10.70 52 486347 44708 110058192
Adverse drug reaction 75.02 10.70 752 485647 104807 109998093
Neutrophil count decreased 74.91 10.70 276 486123 120665 109982235
Finger deformity 74.78 10.70 26 486373 33066 110069834
Electrocardiogram QRS complex shortened 74.72 10.70 46 486353 774 110102126
Embolism venous 74.61 10.70 101 486298 4922 110097978
Respiratory tract infection 74.50 10.70 125 486274 71492 110031408
Rheumatic fever 74.40 10.70 846 485553 121733 109981167
Angina pectoris 73.23 10.70 100 486299 62195 110040705
Stereotypy 72.77 10.70 49 486350 968 110101932
Retinitis 72.29 10.70 308 486091 32019 110070881
Accidental overdose 72.14 10.70 432 485967 51402 110051498
Panic attack 72.04 10.70 285 486114 28655 110074245
Drug ineffective 71.97 10.70 5737 480662 1514803 108588097
Cataract 71.87 10.70 151 486248 79334 110023566
Torsade de pointes 71.86 10.70 241 486158 22359 110080541
Pneumothorax 71.12 10.70 33 486366 35252 110067648
Haematotoxicity 70.30 10.70 6 486393 21076 110081824
Maternal exposure during pregnancy 70.21 10.70 1540 484859 253343 109849557
Prostate cancer 70.19 10.70 39 486360 37602 110065298
Antipsychotic drug level above therapeutic 70.14 10.70 69 486330 2371 110100529
Surgery 69.73 10.70 48 486351 41235 110061665
Rash maculo-papular 69.66 10.70 138 486261 74084 110028816
Lymphadenopathy 69.61 10.70 108 486291 63727 110039173
Cytopenia 69.20 10.70 23 486376 30093 110072807
Tic 69.03 10.70 81 486318 3412 110099488
Chronic kidney disease 68.93 10.70 145 486254 76146 110026754
Metastases to liver 68.43 10.70 35 486364 35351 110067549
Slow speech 68.21 10.70 80 486319 3368 110099532
Parkinsonian gait 68.10 10.70 48 486351 1024 110101876
Pulmonary arterial hypertension 67.94 10.70 29 486370 32539 110070361
Cytomegalovirus infection reactivation 67.77 10.70 3 486396 18330 110084570
Lymphocyte count decreased 67.18 10.70 92 486307 57151 110045749
Neoplasm malignant 67.10 10.70 40 486359 37103 110065797
Tenderness 66.74 10.70 23 486376 29414 110073486
Tachyphrenia 66.56 10.70 66 486333 2290 110100610
Mouth ulceration 66.51 10.70 68 486331 48070 110054830
Road traffic accident 66.43 10.70 744 485655 106654 109996246
Lip dry 66.37 10.70 703 485696 99380 110003520
Multiple organ dysfunction syndrome 66.29 10.70 393 486006 151317 109951583
Abulia 65.87 10.70 51 486348 1262 110101638
Hypertonia 65.47 10.70 126 486273 8280 110094620
Sympathomimetic effect 65.44 10.70 26 486373 155 110102745
Osteomyelitis 65.30 10.70 40 486359 36560 110066340
Respiratory tract congestion 65.13 10.70 27 486372 30830 110072070
COVID-19 pneumonia 64.33 10.70 42 486357 37101 110065799
Osteonecrosis 64.31 10.70 34 486365 33707 110069193
Neuralgia 64.17 10.70 71 486328 48407 110054493
Drug level increased 64.06 10.70 394 486005 47325 110055575
Oral pain 63.96 10.70 43 486356 37401 110065499
Aspartate aminotransferase increased 63.86 10.70 426 485973 159510 109943390
Acute psychosis 63.28 10.70 93 486306 4894 110098006
Coma blister 62.46 10.70 27 486372 205 110102695
Status epilepticus 62.45 10.70 290 486109 31281 110071619
Hypophosphataemia 62.42 10.70 34 486365 33148 110069752
Granulocytopenia 62.03 10.70 158 486241 12557 110090343
Hypoacusis 62.03 10.70 39 486360 35152 110067748
Illusion 61.91 10.70 59 486340 1948 110100952
Hypersexuality 61.70 10.70 58 486341 1882 110101018
Reduced facial expression 61.34 10.70 78 486321 3573 110099327
Progressive multifocal leukoencephalopathy 61.07 10.70 17 486382 24939 110077961
Metastases to central nervous system 60.79 10.70 13 486386 22804 110080096
Jaundice cholestatic 60.65 10.70 171 486228 14437 110088463
Candida infection 60.64 10.70 73 486326 47936 110054964
Off label use 60.44 10.70 5731 480668 1494454 108608446
Bruxism 60.32 10.70 91 486308 4903 110097997
Vasculitis 60.20 10.70 42 486357 35831 110067069
Psoriatic arthropathy 60.09 10.70 1207 485192 195554 109907346
Haemophagocytic lymphohistiocytosis 59.86 10.70 32 486367 31527 110071373
Swelling face 59.62 10.70 207 486192 92114 110010786
Cytomegalovirus viraemia 59.39 10.70 5 486394 17759 110085141
Substance dependence 59.35 10.70 38 486361 687 110102213
Gangrene 59.35 10.70 3 486396 16338 110086562
Hypotonia 59.30 10.70 178 486221 15567 110087333
Haemoptysis 59.25 10.70 142 486257 71212 110031688
Cystitis 59.25 10.70 126 486273 65910 110036990
Hyperammonaemia 59.24 10.70 163 486236 13569 110089331
Increased appetite 58.97 10.70 172 486227 14805 110088095
Somatic symptom disorder 58.71 10.70 71 486328 3088 110099812
Dystonic tremor 58.52 10.70 30 486369 347 110102553
X-ray abnormal 58.47 10.70 326 486073 37791 110065109
Osmolar gap increased 58.38 10.70 25 486374 185 110102715
Self-destructive behaviour 58.34 10.70 40 486359 815 110102085
Incorrect route of product administration 58.05 10.70 481 485918 63580 110039320
Lip swelling 57.89 10.70 83 486316 50584 110052316
Refusal of examination 57.54 10.70 26 486373 222 110102678
Hepatitis 57.43 10.70 203 486196 89851 110013049
Total lung capacity increased 57.32 10.70 90 486309 5022 110097878
Injection site rash 57.22 10.70 16 486383 23403 110079497
Brain injury 57.18 10.70 159 486240 13317 110089583
Chronic obstructive pulmonary disease 57.08 10.70 266 486133 108892 109994008
Female genital tract fistula 57.06 10.70 4 486395 16515 110086385
Sneezing 57.00 10.70 35 486364 31949 110070951
Ataxia 56.95 10.70 273 486126 29835 110073065
Psychosexual disorder 56.95 10.70 23 486376 144 110102756
Eye pruritus 56.85 10.70 37 486362 32738 110070162
Appendicitis 56.78 10.70 27 486372 28437 110074463
Heart rate decreased 56.57 10.70 181 486218 82575 110020325
Hyperhidrosis 56.55 10.70 1147 485252 186151 109916749
Tooth infection 56.52 10.70 14 486385 22202 110080698
Burning sensation 56.48 10.70 139 486260 69073 110033827
Infection 56.39 10.70 1189 485210 361011 109741889
Pathogen resistance 56.36 10.70 6 486393 17666 110085234
Affective disorder 56.22 10.70 141 486258 11100 110091800
Ulcer 56.13 10.70 64 486335 43052 110059848
Freezing phenomenon 55.76 10.70 63 486336 2546 110100354
Resting tremor 55.73 10.70 52 486347 1671 110101229
Haemorrhoids 55.71 10.70 45 486354 35627 110067273
Dry eye 55.65 10.70 100 486299 55693 110047207
Nephrogenic diabetes insipidus 55.63 10.70 61 486338 2384 110100516
Stoma site discharge 55.54 10.70 65 486334 2730 110100170
Negativism 55.34 10.70 40 486359 889 110102011
Blood triglycerides increased 55.09 10.70 230 486169 23696 110079204
Onychomadesis 55.00 10.70 72 486327 45591 110057309
Screaming 54.82 10.70 86 486313 4795 110098105
Food interaction 54.81 10.70 57 486342 2095 110100805
Mutism 54.68 10.70 68 486331 3045 110099855
Skin disorder 54.47 10.70 65 486334 42848 110060052
Squamous cell carcinoma of skin 54.46 10.70 6 486393 17197 110085703
Paraesthesia oral 54.45 10.70 41 486358 33630 110069270
Schizophreniform disorder 54.43 10.70 23 486376 164 110102736
Wrong patient received product 54.41 10.70 102 486297 6572 110096328
Transfusion 54.23 10.70 22 486377 25450 110077450
Neurodegenerative disorder 54.12 10.70 37 486362 750 110102150
Incoherent 54.07 10.70 116 486283 8242 110094658
Sleep disorder 53.99 10.70 1198 485201 197446 109905454
Libido decreased 53.83 10.70 95 486304 5840 110097060
Hypertriglyceridaemia 53.81 10.70 175 486224 15979 110086921
International normalised ratio increased 53.75 10.70 198 486201 86574 110016326
Homicide 53.41 10.70 42 486357 1064 110101836
Circulatory collapse 53.39 10.70 348 486051 42645 110060255
Tenosynovitis 53.31 10.70 5 486394 16278 110086622
Skin lesion 52.89 10.70 91 486308 51540 110051360
Bursitis 52.84 10.70 834 485565 129084 109973816
Pulmonary alveolar haemorrhage 52.64 10.70 12 486387 20138 110082762
Squamous cell carcinoma 52.41 10.70 9 486390 18454 110084446
Sexually inappropriate behaviour 52.05 10.70 34 486365 637 110102263
Injection site urticaria 52.05 10.70 7 486392 17208 110085692
Fibromyalgia 52.04 10.70 1048 485351 169861 109933039
Therapeutic product effect variable 52.01 10.70 62 486337 2656 110100244
Acute respiratory failure 51.87 10.70 164 486235 75096 110027804
Oxygen saturation decreased 51.81 10.70 441 485958 156541 109946359
Tendonitis 51.64 10.70 25 486374 26058 110076842
Postural tremor 51.25 10.70 40 486359 1002 110101898
Toxic epidermal necrolysis 51.09 10.70 108 486291 56619 110046281
Red blood cell count decreased 51.01 10.70 136 486263 65787 110037113
Congestive cardiomyopathy 50.98 10.70 158 486241 14061 110088839
Gastric disorder 50.95 10.70 43 486356 33314 110069586
Hyperphagia 50.93 10.70 70 486329 3461 110099439
Necrotising colitis 50.90 10.70 50 486349 1715 110101185
Dysphoria 50.86 10.70 97 486302 6331 110096569
Gastrointestinal disorder 50.82 10.70 753 485646 241199 109861701
Hypersomnia 50.61 10.70 251 486148 27810 110075090
Oropharyngeal spasm 50.59 10.70 30 486369 470 110102430
Poverty of speech 50.44 10.70 32 486367 569 110102331
Pemphigus 50.35 10.70 1268 485131 213302 109889598
Insomnia 50.28 10.70 2001 484398 358589 109744311
Hypersensitivity 50.27 10.70 1372 485027 402626 109700274
Emotional disorder 50.21 10.70 171 486228 15989 110086911
Pulmonary fibrosis 50.16 10.70 677 485722 101365 110001535
Blood creatinine increased 50.07 10.70 538 485861 182351 109920549
Psychotic behaviour 49.98 10.70 45 486354 1380 110101520
Right ventricular failure 49.70 10.70 26 486373 25928 110076972
Oppositional defiant disorder 49.61 10.70 30 486369 488 110102412
Pancreatitis 49.51 10.70 629 485770 92904 110009996
Jealous delusion 49.49 10.70 29 486370 444 110102456
Penile abscess 49.42 10.70 20 486379 126 110102774
Menstrual disorder 49.23 10.70 81 486318 4703 110098197
Cerebellar atrophy 49.22 10.70 45 486354 1408 110101492
Spasmodic dysphonia 49.22 10.70 31 486368 544 110102356
Blood calcium decreased 49.11 10.70 51 486348 35794 110067106
Posterior reversible encephalopathy syndrome 48.90 10.70 46 486353 33815 110069085
Blood pressure fluctuation 48.84 10.70 167 486232 74657 110028243
Inappropriate affect 48.75 10.70 48 486351 1651 110101249
Personality change due to a general medical condition 48.71 10.70 25 486374 290 110102610
Oral herpes 48.68 10.70 52 486347 36028 110066872
Judgement impaired 48.63 10.70 43 486356 1287 110101613
Gastritis 48.56 10.70 102 486297 53597 110049303
Blood uric acid increased 48.50 10.70 17 486382 21512 110081388
Stoma site erythema 48.49 10.70 53 486346 2064 110100836
Joint range of motion decreased 48.38 10.70 779 485620 121053 109981847
Labelled drug-food interaction issue 48.28 10.70 19 486380 110 110102790
Hypocalcaemia 48.23 10.70 138 486261 65228 110037672
Toxic encephalopathy 48.16 10.70 162 486237 15052 110087848
Urinary hesitation 48.11 10.70 79 486320 4579 110098321
Illness 48.00 10.70 192 486207 81979 110020921
Electrocardiogram abnormal 47.99 10.70 186 486213 18523 110084377
Suspiciousness 47.93 10.70 34 486365 733 110102167
Trismus 47.90 10.70 96 486303 6500 110096400
Therapeutic product effect incomplete 47.88 10.70 694 485705 223111 109879789
Brugada syndrome 47.69 10.70 46 486353 1542 110101358
Bladder cancer 47.50 10.70 15 486384 20277 110082623
Bone disorder 47.29 10.70 17 486382 21175 110081725
Chest pain 47.13 10.70 1277 485122 375098 109727802
Abnormal weight gain 47.07 10.70 68 486331 3523 110099377
Alcoholism 46.85 10.70 69 486330 3638 110099262
Faeces discoloured 46.85 10.70 48 486351 33900 110069000
Arterial occlusive disease 46.83 10.70 6 486393 15302 110087598
Muscle injury 46.80 10.70 875 485524 139932 109962968
Coagulopathy 46.76 10.70 67 486332 40844 110062056
Skin necrosis 46.75 10.70 18 486381 21494 110081406
Second primary malignancy 46.72 10.70 11 486388 18057 110084843
Rabbit syndrome 46.46 10.70 26 486373 363 110102537
Proctitis 46.44 10.70 9 486390 16918 110085982
Venoocclusive liver disease 46.42 10.70 6 486393 15201 110087699
Malignant melanoma 46.30 10.70 9 486390 16882 110086018
Proteinuria 46.27 10.70 65 486334 39953 110062947
Gingival pain 46.18 10.70 7 486392 15729 110087171
Porphyria acute 45.98 10.70 184 486215 18596 110084304
Vomiting 45.86 10.70 3417 482982 907258 109195642
Uveitis 45.82 10.70 19 486380 21691 110081209
Carpal tunnel syndrome 45.79 10.70 21 486378 22589 110080311
Intervertebral disc protrusion 45.73 10.70 33 486366 27665 110075235
Metastases to lymph nodes 45.72 10.70 6 486393 15026 110087874
Incontinence 45.66 10.70 169 486230 16466 110086434
Acute generalised exanthematous pustulosis 45.65 10.70 19 486380 21645 110081255
Pericarditis 45.41 10.70 1274 485125 217840 109885060
Sudden death 45.28 10.70 220 486179 24175 110078725
Bone density decreased 45.15 10.70 8 486391 16034 110086866
Multiple drug therapy 44.87 10.70 105 486294 7909 110094991
Infarction 44.80 10.70 82 486317 5187 110097713
Paroxysmal perceptual alteration 44.80 10.70 23 486376 267 110102633
Diffuse large B-cell lymphoma 44.58 10.70 8 486391 15890 110087010
Anticonvulsant drug level above therapeutic 44.55 10.70 40 486359 1222 110101678
Sudden cardiac death 44.53 10.70 85 486314 5552 110097348
Manic symptom 44.35 10.70 23 486376 273 110102627
Infusion related reaction 43.97 10.70 1308 485091 379854 109723046
Flatulence 43.92 10.70 103 486296 52046 110050854
Clostridium difficile infection 43.87 10.70 103 486296 52026 110050874
Urticaria 43.87 10.70 1067 485332 317790 109785110
Device difficult to use 43.85 10.70 14 486385 18791 110084109
Feeling guilty 43.70 10.70 35 486364 911 110101989
Drug dose omission by device 43.66 10.70 6 486393 14510 110088390
Feelings of worthlessness 43.59 10.70 29 486370 561 110102339
Bundle branch block right 43.54 10.70 136 486263 12155 110090745
Loss of libido 43.53 10.70 61 486338 3072 110099828
Initial insomnia 43.51 10.70 122 486277 10267 110092633
Attention deficit hyperactivity disorder 43.49 10.70 74 486325 4417 110098483
Asthma-chronic obstructive pulmonary disease overlap syndrome 43.31 10.70 90 486309 6254 110096646
Alanine aminotransferase increased 43.21 10.70 559 485840 183214 109919686
Skin haemorrhage 43.10 10.70 28 486371 24799 110078101
Electrocardiogram QT interval abnormal 43.08 10.70 24 486375 332 110102568
Disseminated intravascular coagulation 42.99 10.70 72 486327 41214 110061686
Paradoxical drug reaction 42.82 10.70 117 486282 9700 110093200
Tooth disorder 42.72 10.70 40 486359 29469 110073431
Death 42.58 10.70 2578 483821 696291 109406609
Organising pneumonia 42.57 10.70 6 486393 14237 110088663
Nightmare 42.56 10.70 305 486094 38558 110064342
Influenza like illness 42.45 10.70 222 486177 88190 110014710
Injection site warmth 42.32 10.70 12 486387 17393 110085507
Breast cancer stage III 42.28 10.70 533 485866 78584 110024316
Dependence 42.26 10.70 56 486343 2673 110100227
Cystitis haemorrhagic 42.05 10.70 3 486396 12206 110090694
Ejection fraction decreased 41.92 10.70 72 486327 40808 110062092
Generalised oedema 41.71 10.70 44 486355 30660 110072240
Rectal haemorrhage 41.65 10.70 332 486067 119501 109983399
Flight of ideas 41.60 10.70 32 486367 784 110102116
Product dose omission in error 41.52 10.70 26 486373 23486 110079414
Antidepressant drug level above therapeutic 41.50 10.70 31 486368 726 110102174
Panniculitis 41.27 10.70 9 486390 15573 110087327
Product storage error 41.26 10.70 22 486377 21706 110081194
Blood urine present 41.20 10.70 28 486371 24217 110078683
Post procedural complication 41.17 10.70 34 486365 26624 110076276
Gastric ulcer 40.97 10.70 70 486329 39757 110063143
Social anxiety disorder 40.96 10.70 34 486365 932 110101968
Enterocolitis 40.94 10.70 16 486383 18933 110083967
Borderline personality disorder 40.75 10.70 36 486363 1076 110101824
Blunted affect 40.74 10.70 27 486372 519 110102381
Antipsychotic drug level decreased 40.72 10.70 40 486359 1372 110101528
Radiculopathy 40.68 10.70 17 486382 19319 110083581
Muscular weakness 40.62 10.70 809 485590 247659 109855241
Staphylococcal infection 40.49 10.70 164 486235 69780 110033120
Conversion disorder 40.40 10.70 51 486348 2319 110100581
Product label confusion 40.15 10.70 25 486374 22652 110080248
Brain hypoxia 40.14 10.70 38 486361 1244 110101656
Tuberculosis 40.10 10.70 14 486385 17760 110085140
Gastroenteritis 40.10 10.70 68 486331 38732 110064168
Aplastic anaemia 40.08 10.70 29 486370 24279 110078621
Lymphopenia 40.06 10.70 72 486327 40098 110062802
Hypoalbuminaemia 39.95 10.70 41 486358 28933 110073967
Melaena 39.94 10.70 161 486238 68596 110034304
Self esteem decreased 39.74 10.70 35 486364 1042 110101858
Herbal interaction 39.70 10.70 28 486371 598 110102302
Impaired quality of life 39.68 10.70 44 486355 29973 110072927
Withdrawal catatonia 39.55 10.70 24 486375 393 110102507
Mental status changes 39.48 10.70 510 485889 75612 110027288
Skin fissures 39.27 10.70 30 486369 24428 110078472
Oesophageal candidiasis 39.25 10.70 3 486396 11531 110091369
Oesophageal carcinoma 39.21 10.70 3 486396 11521 110091379
Post procedural haemorrhage 39.03 10.70 10 486389 15502 110087398
Pressure of speech 38.91 10.70 38 486361 1294 110101606
Acute coronary syndrome 38.86 10.70 27 486372 23085 110079815
Oscillopsia 38.77 10.70 24 486375 408 110102492
Pneumonia bacterial 38.72 10.70 35 486364 26226 110076674
Epstein-Barr virus infection 38.58 10.70 17 486382 18721 110084179
Crying 38.52 10.70 218 486181 25410 110077490
Transient ischaemic attack 38.32 10.70 148 486251 63834 110039066
Pulmonary toxicity 38.32 10.70 15 486384 17731 110085169
Muscle twitching 38.21 10.70 244 486155 29691 110073209
Compartment syndrome 38.20 10.70 82 486317 5828 110097072
Shock haemorrhagic 38.20 10.70 38 486361 27209 110075691
Language disorder 38.18 10.70 64 486335 3774 110099126
Bronchospasm 38.17 10.70 46 486353 30193 110072707
Pyromania 38.16 10.70 11 486388 18 110102882
Lacrimation increased 38.10 10.70 48 486351 30902 110071998
Dementia with Lewy bodies 38.05 10.70 34 486365 1032 110101868
Corneal reflex decreased 38.03 10.70 26 486373 527 110102373
Rash macular 37.99 10.70 70 486329 38616 110064284
Immune reconstitution inflammatory syndrome 37.98 10.70 12 486387 16214 110086686
Conjunctivitis 37.97 10.70 56 486343 33736 110069164
Aortic stenosis 37.89 10.70 6 486393 13053 110089847
Diet refusal 37.87 10.70 31 486368 833 110102067
Electrocardiogram repolarisation abnormality 37.84 10.70 49 486350 2286 110100614
Haematoma 37.83 10.70 131 486268 58345 110044555
Dermatitis 37.69 10.70 40 486359 27797 110075103
Labelled drug-drug interaction issue 37.66 10.70 66 486333 4035 110098865
Gastrointestinal toxicity 37.65 10.70 3 486396 11145 110091755
Rhinovirus infection 37.61 10.70 4 486395 11785 110091115
Upper gastrointestinal haemorrhage 37.52 10.70 105 486294 49991 110052909
Slow response to stimuli 37.47 10.70 45 486354 1943 110100957
Trichoglossia 37.37 10.70 31 486368 849 110102051
Graft versus host disease 37.27 10.70 18 486381 18788 110084112
Binge eating 37.24 10.70 27 486372 603 110102297
Product substitution issue 37.23 10.70 200 486199 22861 110080039
Wound 37.23 10.70 1320 485079 233117 109869783
Respiratory syncytial virus infection 37.09 10.70 9 486390 14475 110088425
Colon cancer 37.01 10.70 13 486386 16430 110086470
Polyneuropathy 37.01 10.70 52 486347 31960 110070940
Troponin increased 37.00 10.70 241 486158 29525 110073375
Withdrawal arrhythmia 36.91 10.70 13 486386 52 110102848
Leukopenia 36.91 10.70 886 485513 147905 109954995
Ocular hyperaemia 36.90 10.70 73 486326 39213 110063687
Anti-cyclic citrullinated peptide antibody positive 36.84 10.70 1055 485344 180929 109921971
Sedation complication 36.81 10.70 179 486220 19676 110083224
Renal tubular necrosis 36.75 10.70 48 486351 30427 110072473
C-reactive protein 36.74 10.70 244 486155 30087 110072813
Decreased appetite 36.72 10.70 1714 484685 474132 109628768
Affect lability 36.72 10.70 171 486228 18466 110084434
Drug therapy enhancement 36.71 10.70 13 486386 53 110102847
Anxiolytic therapy 36.71 10.70 13 486386 53 110102847
Amimia 36.47 10.70 14 486385 75 110102825
Blood alkaline phosphatase increased 36.41 10.70 174 486225 70761 110032139
Self-medication 36.37 10.70 83 486316 6149 110096751
Decreased eye contact 36.32 10.70 31 486368 884 110102016
Anaemia of pregnancy 36.23 10.70 15 486384 101 110102799
Tongue spasm 36.20 10.70 16 486383 129 110102771
Pulmonary mass 36.18 10.70 68 486331 37233 110065667
Anion gap increased 36.17 10.70 67 486332 4277 110098623
Joint injury 36.13 10.70 76 486323 39918 110062982
Thrombotic microangiopathy 36.10 10.70 45 486354 29104 110073796
Eye irritation 36.09 10.70 57 486342 33395 110069505
Palpitations 36.07 10.70 488 485911 158724 109944176
Grip strength 36.01 10.70 105 486294 9036 110093864
Autonomic nervous system imbalance 36.00 10.70 79 486320 5701 110097199
Potentiating drug interaction 36.00 10.70 123 486276 11520 110091380
Hyporesponsive to stimuli 35.81 10.70 53 486346 2807 110100093
Femur fracture 35.74 10.70 90 486309 44379 110058521
Prostatic specific antigen increased 35.73 10.70 6 486393 12505 110090395
Urine osmolarity increased 35.69 10.70 20 486379 280 110102620
Food allergy 35.67 10.70 178 486221 19770 110083130
Cardiac tamponade 35.65 10.70 4 486395 11303 110091597
Arrhythmia 35.60 10.70 465 485934 69110 110033790
Gambling disorder 35.54 10.70 46 486353 2145 110100755
Abscess 35.51 10.70 41 486358 27428 110075472
Urinary incontinence 35.42 10.70 348 486051 48239 110054661
Pulmonary haemorrhage 35.38 10.70 14 486385 16442 110086458
Dissociative disorder 35.26 10.70 35 486364 1216 110101684
Cardiac disorder 35.25 10.70 194 486205 76086 110026814
Hemiplegia 35.25 10.70 29 486370 22753 110080147
Floppy iris syndrome 35.20 10.70 21 486378 333 110102567
Skin reaction 35.16 10.70 25 486374 21119 110081781
Breath sounds abnormal 34.97 10.70 36 486363 25368 110077532
Gait disturbance 34.93 10.70 1527 484872 276681 109826219
Drug eruption 34.86 10.70 120 486279 53539 110049361
Paronychia 34.74 10.70 4 486395 11077 110091823
Excessive eye blinking 34.71 10.70 42 486357 1828 110101072
Wound infection 34.70 10.70 607 485792 95858 110007042
Peripartum cardiomyopathy 34.55 10.70 17 486382 179 110102721
Pyelonephritis 34.51 10.70 36 486363 25214 110077686
Night sweats 34.51 10.70 802 485597 133181 109969719
Infective pulmonary exacerbation of cystic fibrosis 34.43 10.70 11 486388 14760 110088140
Skin infection 34.40 10.70 29 486370 22480 110080420
Device malfunction 34.30 10.70 37 486362 25521 110077379
Blood iron decreased 34.27 10.70 21 486378 19193 110083707
Dermatitis atopic 34.25 10.70 37 486362 25504 110077396
Amniotic fluid volume increased 34.22 10.70 16 486383 149 110102751
Drug diversion 34.16 10.70 36 486363 1344 110101556
Enteritis 34.08 10.70 21 486378 19135 110083765
Enterococcal infection 33.97 10.70 24 486375 20342 110082558
Musculoskeletal discomfort 33.96 10.70 32 486367 23506 110079394
Diverticulum 33.73 10.70 13 486386 15513 110087387
Immune-mediated enterocolitis 33.69 10.70 3 486396 10182 110092718
Muscle spasticity 33.51 10.70 67 486332 35848 110067052
Breast cancer female 33.43 10.70 7 486392 12461 110090439
Blood phosphorus increased 33.37 10.70 15 486384 16325 110086575
Acute graft versus host disease in skin 33.36 10.70 4 486395 10736 110092164
Cholangitis 33.35 10.70 15 486384 16320 110086580
Respiratory symptom 33.33 10.70 12 486387 14933 110087967
Adverse reaction 33.30 10.70 49 486350 29545 110073355
Dry mouth 33.29 10.70 1132 485267 198816 109904084
Libido increased 33.16 10.70 48 486351 2491 110100409
Injection site haemorrhage 33.11 10.70 59 486340 32969 110069931
Alcohol poisoning 33.06 10.70 101 486298 8919 110093981
Ageusia 32.97 10.70 23 486376 19622 110083278
Delusional disorder, unspecified type 32.96 10.70 29 486370 862 110102038
Protein C increased 32.95 10.70 12 486387 54 110102846
Duodenal ulcer perforation 32.94 10.70 1019 485380 176681 109926219
Parkinsonian rest tremor 32.83 10.70 21 486378 379 110102521
Sluggishness 32.82 10.70 90 486309 7477 110095423
Musculoskeletal stiffness 32.76 10.70 1525 484874 278297 109824603
Inappropriate antidiuretic hormone secretion 32.74 10.70 258 486141 33593 110069307
Cardiac failure chronic 32.71 10.70 10 486389 13801 110089099
Communication disorder 32.67 10.70 70 486329 4969 110097931
Pneumonia viral 32.65 10.70 5 486394 11152 110091748
Delusional disorder, persecutory type 32.62 10.70 25 486374 609 110102291
Dyslipidaemia 32.57 10.70 148 486251 15817 110087083
Haemolysis 32.50 10.70 14 486385 15625 110087275
Feeling of body temperature change 32.40 10.70 79 486320 6109 110096791
Spinal stenosis 32.39 10.70 22 486377 19034 110083866
SARS-CoV-2 test positive 32.37 10.70 17 486382 16918 110085982
Schizoaffective disorder bipolar type 32.36 10.70 19 486380 292 110102608
H1N1 influenza 32.28 10.70 52 486347 2966 110099934
Creatinine renal clearance decreased 32.25 10.70 29 486370 21786 110081114
Negative thoughts 32.25 10.70 38 486361 1608 110101292
Lymphoma 32.06 10.70 25 486374 20146 110082754
Sciatica 32.03 10.70 578 485821 91821 110011079
Action tremor 32.01 10.70 22 486377 450 110102450
Rebound psychosis 31.99 10.70 21 486378 397 110102503
Hip arthroplasty 31.98 10.70 381 486018 55432 110047468
Seasonal allergy 31.91 10.70 24 486375 19698 110083202
Hallucination, olfactory 31.84 10.70 24 486375 570 110102330
Hypogammaglobulinaemia 31.76 10.70 25 486374 20051 110082849
Product tampering 31.72 10.70 22 486377 457 110102443
Renal cancer 31.67 10.70 9 486390 13025 110089875
Gastrooesophageal reflux disease 31.56 10.70 579 485820 179397 109923503
Multiple sclerosis relapse 31.53 10.70 114 486285 50126 110052774
Stoma site hypergranulation 31.48 10.70 24 486375 580 110102320
Herpes simplex 31.37 10.70 15 486384 15749 110087151
Myasthenia gravis 31.32 10.70 29 486370 21482 110081418
Live birth 31.32 10.70 454 485945 69030 110033870
Oedema 31.32 10.70 1174 485225 208802 109894098
Cerebral haemorrhage 31.26 10.70 163 486236 64805 110038095
Red blood cell sedimentation rate abnormal 31.24 10.70 37 486362 24472 110078428
Drug intolerance 31.21 10.70 1465 484934 405047 109697853
Kidney infection 31.20 10.70 40 486359 25559 110077341
Otospondylomegaepiphyseal dysplasia 31.08 10.70 10 486389 28 110102872
Burning mouth syndrome 31.04 10.70 25 486374 656 110102244
Physical assault 30.93 10.70 37 486362 1591 110101309
Gynaecomastia 30.88 10.70 102 486297 9388 110093512
Therapeutic product ineffective 30.81 10.70 47 486352 2557 110100343
Angina unstable 30.67 10.70 17 486382 16415 110086485
Atrioventricular block first degree 30.63 10.70 134 486265 14091 110088809
Mucormycosis 30.57 10.70 5 486394 10623 110092277
Iron deficiency 30.52 10.70 22 486377 18454 110084446
Hepatic cancer 30.46 10.70 6 486393 11150 110091750
Rotator cuff syndrome 30.45 10.70 18 486381 16776 110086124
Obsessive thoughts 30.42 10.70 33 486366 1274 110101626
Diabetes insipidus 30.36 10.70 80 486319 6490 110096410
Ileus paralytic 30.36 10.70 117 486282 11620 110091280
Cerebral infarction 30.35 10.70 121 486278 51717 110051183
Wrong dose 30.21 10.70 47 486352 2602 110100298
Pyramidal tract syndrome 30.20 10.70 27 486372 820 110102080
Vasoplegia syndrome 30.16 10.70 71 486328 5368 110097532
Psychotic disorder due to a general medical condition 30.03 10.70 18 486381 288 110102612
Unevaluable event 29.98 10.70 146 486253 59081 110043819
Osteopenia 29.97 10.70 32 486367 22177 110080723
Cholecystitis acute 29.94 10.70 16 486383 15766 110087134
Ventricular arrhythmia 29.83 10.70 105 486294 9982 110092918
Blindness 29.68 10.70 73 486326 36286 110066614
Injury 29.61 10.70 1004 485395 176261 109926639
Stress 29.59 10.70 308 486091 105040 109997860
Immunosuppression 29.53 10.70 21 486378 17738 110085162
Hypocholesterolaemia 29.49 10.70 78 486321 6343 110096557
Atrial flutter 29.48 10.70 38 486361 24224 110078676
Peritonitis 29.43 10.70 62 486337 32545 110070355
Substance use 29.33 10.70 45 486354 2461 110100439
Colorectal cancer 29.31 10.70 3 486396 9111 110093789
Movement disorder 29.15 10.70 266 486133 36138 110066762
Hyperphosphataemia 29.09 10.70 18 486381 16363 110086537
Tonic clonic movements 29.06 10.70 49 486350 2903 110099997
Camptocormia 29.04 10.70 21 486378 467 110102433
Convulsive threshold lowered 28.99 10.70 29 486370 1017 110101883
Atelectasis 28.97 10.70 75 486324 36637 110066263
End stage renal disease 28.91 10.70 31 486368 21442 110081458
Therapeutic product effect decreased 28.75 10.70 836 485563 243480 109859420
Graft versus host disease in gastrointestinal tract 28.72 10.70 3 486396 8965 110093935
Epilepsy 28.70 10.70 609 485790 99600 110003300
Nodule 28.66 10.70 63 486336 32568 110070332
Immune thrombocytopenia 28.62 10.70 34 486365 22460 110080440
Cushingoid 28.62 10.70 8 486391 11704 110091196
Eosinophil count decreased 28.55 10.70 74 486325 5944 110096956
Bacterial infection 28.54 10.70 105 486294 45931 110056969
Hepatic enzyme increased 28.52 10.70 1704 484695 319188 109783712
Nuchal rigidity 28.49 10.70 31 486368 1201 110101699
Postoperative wound infection 28.40 10.70 17 486382 15736 110087164
Wrong technique in product usage process 28.09 10.70 247 486152 87101 110015799
Musculoskeletal disorder 28.05 10.70 35 486364 22629 110080271
Abdominal pain lower 28.03 10.70 78 486321 37205 110065695
Immune effector cell-associated neurotoxicity syndrome 28.02 10.70 15 486384 14767 110088133
Erectile dysfunction 27.99 10.70 158 486241 18398 110084502
Penis injury 27.99 10.70 13 486386 119 110102781
Adjustment disorder with mixed anxiety and depressed mood 27.99 10.70 13 486386 119 110102781
Hyperbilirubinaemia 27.95 10.70 58 486341 30613 110072287
Respiratory failure 27.87 10.70 727 485672 214605 109888295
Waxy flexibility 27.77 10.70 17 486382 283 110102617
Rhinitis 27.72 10.70 35 486364 22510 110080390
Antisocial behaviour 27.70 10.70 26 486373 842 110102058
Urine alcohol test positive 27.64 10.70 10 486389 44 110102856
Neurologic neglect syndrome 27.60 10.70 4 486395 9294 110093606
Delusional perception 27.59 10.70 19 486380 390 110102510
Merycism 27.57 10.70 18 486381 337 110102563
Pupillary reflex impaired 27.45 10.70 57 486342 3958 110098942
Rib fracture 27.41 10.70 68 486331 33702 110069198
Haemolytic anaemia 27.29 10.70 31 486368 20889 110082011
Lupus-like syndrome 27.26 10.70 287 486112 40505 110062395
Eye swelling 27.25 10.70 66 486333 32982 110069918
Autism spectrum disorder 27.17 10.70 38 486361 1910 110100990
Staring 27.15 10.70 47 486352 2845 110100055
Haemorrhage intracranial 27.06 10.70 54 486345 28915 110073985
Haematocrit decreased 26.94 10.70 175 486224 65942 110036958
Guillain-Barre syndrome 26.89 10.70 7 486392 10737 110092163
Eye movement disorder 26.84 10.70 99 486300 9629 110093271
Intervertebral disc degeneration 26.79 10.70 24 486375 18061 110084839
Blood lactic acid increased 26.77 10.70 139 486260 15682 110087218
Nephropathy toxic 26.73 10.70 50 486349 27428 110075472
Microphthalmos 26.59 10.70 6 486393 0 110102900
Deafness 26.52 10.70 48 486351 26661 110076239
Walking aid user 26.43 10.70 195 486204 24880 110078020
Job dissatisfaction 26.21 10.70 11 486388 77 110102823
Endocarditis 26.19 10.70 13 486386 13358 110089542
Joint effusion 26.17 10.70 32 486367 20873 110082027
Hepatic encephalopathy 26.11 10.70 53 486346 28203 110074697
Orthopnoea 26.06 10.70 8 486391 11013 110091887
Areflexia 25.94 10.70 77 486322 6692 110096208
Spinal fracture 25.93 10.70 37 486362 22596 110080304
Blood potassium decreased 25.91 10.70 136 486263 53978 110048922
Depressive delusion 25.80 10.70 8 486391 19 110102881
Food refusal 25.71 10.70 26 486373 924 110101976
Arthritis infective 25.71 10.70 7 486392 10422 110092478
Refusal of treatment by patient 25.68 10.70 96 486303 9398 110093502
Hypercholesterolaemia 25.67 10.70 551 485848 90286 110012614
Myoclonic epilepsy 25.61 10.70 44 486355 2647 110100253
Violence-related symptom 25.51 10.70 26 486373 933 110101967
Blood osmolarity decreased 25.50 10.70 32 486367 1446 110101454
Hydronephrosis 25.49 10.70 32 486367 20633 110082267
Multiple allergies 25.45 10.70 11 486388 12252 110090648
Electrocardiogram change 25.42 10.70 31 486368 1360 110101540
Distributive shock 25.39 10.70 70 486329 5834 110097066
Eye haemorrhage 25.34 10.70 10 486389 11764 110091136
Urine output decreased 25.34 10.70 30 486369 19846 110083054
Hernia 25.32 10.70 29 486370 19471 110083429
Respiratory distress 25.25 10.70 188 486211 68686 110034214
Splenomegaly 25.25 10.70 43 486356 24455 110078445
Pulmonary oedema 25.22 10.70 302 486097 100357 110002543
Constipation 25.19 10.70 1301 485098 356485 109746415
Excessive masturbation 25.19 10.70 12 486387 117 110102783
Gastrointestinal hypomotility 25.19 10.70 42 486357 2466 110100434
Toxic skin eruption 25.10 10.70 52 486347 27463 110075437
Abnormal loss of weight 25.07 10.70 7 486392 10250 110092650
Cardiac failure acute 25.06 10.70 42 486357 24036 110078864
Arteriosclerosis 25.05 10.70 44 486355 24723 110078177
Purpura 24.96 10.70 43 486356 24345 110078555
Breast cancer metastatic 24.90 10.70 9 486390 11172 110091728
Complication associated with device 24.85 10.70 31 486368 20042 110082858
Compulsions 24.83 10.70 18 486381 402 110102498
Heart rate irregular 24.82 10.70 73 486326 34201 110068699
Respiratory rate decreased 24.76 10.70 72 486327 6186 110096714
Antidepressant drug level increased 24.71 10.70 21 486378 595 110102305
Haemorrhagic stroke 24.69 10.70 15 486384 13774 110089126
Carotid artery thrombosis 24.66 10.70 6 486393 9632 110093268
No adverse event 24.55 10.70 207 486192 73632 110029268
Impaired self-care 24.50 10.70 42 486357 2522 110100378
Obsessive-compulsive personality disorder 24.50 10.70 12 486387 125 110102775
Eye infection 24.36 10.70 17 486382 14501 110088399
Gastric cancer 24.27 10.70 9 486390 10999 110091901
Illness anxiety disorder 24.23 10.70 15 486384 255 110102645
Gingival bleeding 24.18 10.70 31 486368 19808 110083092
Alcohol use 24.17 10.70 55 486344 4067 110098833
Blood pressure diastolic decreased 24.16 10.70 79 486320 35806 110067094
Sexual abuse 24.13 10.70 15 486384 257 110102643
Heparin-induced thrombocytopenia 24.10 10.70 10 486389 11414 110091486
Tongue biting 24.06 10.70 45 486354 2894 110100006
Subarachnoid haemorrhage 23.96 10.70 60 486339 29642 110073258
Decreased interest 23.96 10.70 61 486338 4847 110098053
Compulsive shopping 23.94 10.70 24 486375 844 110102056
Grimacing 23.89 10.70 24 486375 846 110102054
Hospitalisation 23.87 10.70 462 485937 142031 109960869
Foetal exposure during pregnancy 23.83 10.70 80 486319 7425 110095475
Rash papular 23.75 10.70 54 486345 27585 110075315
Water intoxication 23.71 10.70 25 486374 934 110101966
Blood magnesium decreased 23.60 10.70 32 486367 19964 110082936
Stoma site infection 23.54 10.70 34 486365 1761 110101139
Upper-airway cough syndrome 23.54 10.70 21 486378 15836 110087064
Metastasis 23.53 10.70 4 486395 8263 110094637
Starvation ketoacidosis 23.50 10.70 16 486383 322 110102578
Choreoathetosis 23.50 10.70 33 486366 1665 110101235
Skin mass 23.44 10.70 7 486392 9809 110093091
Oral discharge 23.44 10.70 15 486384 271 110102629
Post-traumatic stress disorder 23.38 10.70 73 486326 6523 110096377
Brain natriuretic peptide increased 23.35 10.70 10 486389 11199 110091701
Cervix neoplasm 23.32 10.70 13 486386 180 110102720
Back injury 23.32 10.70 118 486281 47281 110055619
Peripheral arterial occlusive disease 23.31 10.70 6 486393 9274 110093626
Apnoea 23.19 10.70 120 486279 13519 110089381
Spinal compression fracture 23.19 10.70 28 486371 18364 110084536
Hyperuricaemia 23.11 10.70 18 486381 14513 110088387
Therapy cessation 23.04 10.70 110 486289 44747 110058153
Fistula 23.03 10.70 20 486379 15279 110087621
Sense of a foreshortened future 22.97 10.70 6 486393 5 110102895
Meconium in amniotic fluid 22.88 10.70 12 486387 146 110102754
Diarrhoea haemorrhagic 22.87 10.70 21 486378 15618 110087282
Gaze palsy 22.87 10.70 48 486351 3359 110099541
Dyspepsia 22.83 10.70 652 485747 190313 109912587
Morbid thoughts 22.79 10.70 24 486375 895 110102005
Eyelid function disorder 22.79 10.70 19 486380 524 110102376
Neutropenic colitis 22.74 10.70 4 486395 8061 110094839
Nocardiosis 22.74 10.70 3 486396 7483 110095417
Tricuspid valve incompetence 22.73 10.70 44 486355 23829 110079071
Poor venous access 22.66 10.70 46 486353 24476 110078424
Nystagmus 22.64 10.70 106 486293 11471 110091429
Exostosis 22.62 10.70 305 486094 45651 110057249
Gastrointestinal perforation 22.62 10.70 3 486396 7453 110095447
Peritonitis bacterial 22.58 10.70 9 486390 10524 110092376
Synovial cyst 22.56 10.70 11 486388 11419 110091481
Hyperosmolar state 22.55 10.70 22 486377 748 110102152
Peripheral sensory neuropathy 22.55 10.70 24 486375 16656 110086244
Skin discolouration 22.52 10.70 125 486274 48921 110053979
Dermatitis acneiform 22.47 10.70 14 486385 12681 110090219
Large intestine polyp 22.47 10.70 20 486379 15097 110087803
Lung adenocarcinoma 22.39 10.70 7 486392 9524 110093376
Dopamine dysregulation syndrome 22.39 10.70 20 486379 607 110102293
Perinatal depression 22.36 10.70 18 486381 472 110102428
Choking 22.36 10.70 128 486271 14982 110087918
Epigastric discomfort 22.32 10.70 6 486393 9009 110093891
Bacterial sepsis 22.20 10.70 9 486390 10417 110092483
Intestinal pseudo-obstruction 22.20 10.70 47 486352 3309 110099591
Staphylococcal parotitis 22.16 10.70 5 486394 0 110102900
Neonatal neuroblastoma 22.16 10.70 5 486394 0 110102900
Stoma site inflammation 22.13 10.70 25 486374 1010 110101890
Bladder dilatation 22.07 10.70 39 486360 2400 110100500
Mitral valve incompetence 22.01 10.70 74 486325 33255 110069645
Toothache 21.98 10.70 44 486355 23531 110079369
Facial pain 21.96 10.70 21 486378 15318 110087582
Patient uncooperative 21.93 10.70 24 486375 936 110101964
Postmortem blood drug level 21.90 10.70 15 486384 305 110102595
Foot fracture 21.88 10.70 50 486349 25496 110077404
Vaginal discharge 21.81 10.70 28 486371 17880 110085020
Deep vein thrombosis 21.80 10.70 459 485940 139428 109963472
CYP2C19 polymorphism 21.79 10.70 8 486391 37 110102863
Hemiparesis 21.77 10.70 109 486290 43794 110059106
Eye pain 21.76 10.70 130 486269 49969 110052931
Helplessness 21.74 10.70 16 486383 366 110102534
Escherichia infection 21.73 10.70 45 486354 23771 110079129
Grandiosity 21.73 10.70 19 486380 560 110102340
Hostility 21.72 10.70 41 486358 2655 110100245
Chemical submission 21.70 10.70 19 486380 561 110102339
Alanine aminotransferase abnormal 21.67 10.70 7 486392 9327 110093573
Premature delivery 21.64 10.70 66 486333 30566 110072334
Bipolar II disorder 21.61 10.70 18 486381 496 110102404
Hypervigilance 21.58 10.70 20 486379 637 110102263
Gastritis erosive 21.57 10.70 13 486386 11987 110090913
Staphylococcal sepsis 21.56 10.70 27 486372 17427 110085473
Scab 21.55 10.70 16 486383 13220 110089680
Skin irritation 21.49 10.70 24 486375 16295 110086605
Regressive behaviour 21.47 10.70 13 486386 212 110102688
Bacterial parotitis 21.45 10.70 8 486391 39 110102861
Helicobacter infection 21.44 10.70 992 485407 180885 109922015
Retinal detachment 21.43 10.70 11 486388 11089 110091811
Shock 21.40 10.70 343 486056 53245 110049655
Graft versus host disease in skin 21.39 10.70 5 486394 8249 110094651
Hangover 21.35 10.70 39 486360 2463 110100437
Decreased bronchial secretion 21.32 10.70 9 486390 64 110102836
Dermatitis contact 21.29 10.70 18 486381 13935 110088965
Exposure via skin contact 21.27 10.70 16 486383 13131 110089769
Adrenal insufficiency 21.16 10.70 105 486294 42285 110060615
Blood urea increased 21.12 10.70 148 486251 54809 110048091
Persistent genital arousal disorder 21.10 10.70 20 486379 656 110102244
Groin pain 21.08 10.70 22 486377 15406 110087494
Drug screen false positive 21.06 10.70 28 486371 1341 110101559
Chorea 21.04 10.70 45 486354 3190 110099710
Deafness neurosensory 20.98 10.70 8 486391 9611 110093289
Hepatitis B 20.96 10.70 8 486391 9604 110093296
Cytomegalovirus test positive 20.95 10.70 3 486396 7033 110095867
Neonatal infection 20.93 10.70 7 486392 23 110102877
Fear 20.93 10.70 174 486225 23019 110079881
Necrotising fasciitis 20.90 10.70 4 486395 7587 110095313
Drug withdrawal syndrome neonatal 20.88 10.70 15 486384 330 110102570
Hysterectomy 20.86 10.70 5 486394 8109 110094791
Post procedural infection 20.85 10.70 18 486381 13791 110089109
Generalised anxiety disorder 20.85 10.70 41 486358 2738 110100162
Sensitivity to weather change 20.80 10.70 9 486390 10019 110092881
Patient isolation 20.75 10.70 9 486390 69 110102831
Glomerular filtration rate decreased 20.73 10.70 62 486337 28894 110074006
Ulcer haemorrhage 20.73 10.70 170 486229 22401 110080499
Sickle cell anaemia with crisis 20.72 10.70 8 486391 9537 110093363
Parainfluenzae virus infection 20.70 10.70 3 486396 6971 110095929
Gallbladder disorder 20.69 10.70 38 486361 20991 110081909
Dialysis 20.63 10.70 34 486365 19585 110083315
Hypersensitivity myocarditis 20.58 10.70 15 486384 338 110102562
Retinal haemorrhage 20.56 10.70 8 486391 9493 110093407
Accidental exposure to product 20.56 10.70 132 486267 49876 110053024
Renal cyst 20.53 10.70 30 486369 18142 110084758
Conjunctivitis allergic 20.53 10.70 3 486396 6928 110095972
Musculoskeletal chest pain 20.48 10.70 62 486337 28785 110074115
Intestinal perforation 20.47 10.70 38 486361 20906 110081994
Sinus bradycardia 20.44 10.70 209 486190 29274 110073626
Neuroglycopenia 20.43 10.70 25 486374 1101 110101799
Radial nerve palsy 20.39 10.70 17 486382 469 110102431
Autoimmune hepatitis 20.35 10.70 21 486378 14783 110088117
Muscle atrophy 20.35 10.70 17 486382 13237 110089663
Multiple-drug resistance 20.29 10.70 17 486382 13218 110089682
Hepatocellular carcinoma 20.29 10.70 9 486390 9871 110093029
Proctalgia 20.25 10.70 17 486382 13205 110089695
Multiple fractures 20.24 10.70 7 486392 8933 110093967
Drug-induced liver injury 20.20 10.70 389 486010 119678 109983222
Nasal oedema 20.17 10.70 3 486396 6836 110096064
Hepatic failure 20.12 10.70 199 486200 68540 110034360
Cholinergic syndrome 20.11 10.70 27 486372 1305 110101595
Anaphylactoid reaction 20.11 10.70 3 486396 6823 110096077
Swelling 20.10 10.70 1302 485097 349739 109753161
Panic disorder 20.09 10.70 46 486353 3415 110099485
Orthostatic hypotension 20.07 10.70 406 485993 65843 110037057
Abnormal dreams 20.07 10.70 110 486289 12670 110090230
Facial spasm 20.06 10.70 22 486377 860 110102040
Pharyngitis 20.01 10.70 51 486348 25047 110077853
Haematemesis 19.97 10.70 165 486234 58943 110043957
Parkinson's disease 19.96 10.70 29 486370 1510 110101390
Vascular device infection 19.92 10.70 26 486373 16486 110086414
Insurance issue 19.91 10.70 96 486303 10516 110092384
Cyst 19.87 10.70 26 486373 16470 110086430
Peripheral ischaemia 19.84 10.70 12 486387 11046 110091854
Intentional medical device removal by patient 19.73 10.70 17 486382 491 110102409
Nephrotic syndrome 19.72 10.70 19 486380 13812 110089088
Intellectual disability 19.68 10.70 33 486366 1946 110100954
Meniscus injury 19.65 10.70 5 486394 7788 110095112
Small intestinal obstruction 19.62 10.70 74 486325 32139 110070761
Peripheral coldness 19.61 10.70 32 486367 18508 110084392
Bulimia nervosa 19.57 10.70 14 486385 306 110102594
Cholecystitis 19.57 10.70 54 486345 25828 110077072
Spinal pain 19.55 10.70 32 486367 18483 110084417
Scoliosis 19.49 10.70 7 486392 8726 110094174
Liver function test increased 19.48 10.70 273 486126 88275 110014625
Upper limb fracture 19.46 10.70 39 486360 20849 110082051
Renal papillary necrosis 19.45 10.70 16 486383 433 110102467
Pancreatic carcinoma 19.44 10.70 22 486377 14850 110088050
Feeling jittery 19.41 10.70 121 486278 14601 110088299
Spinal osteoarthritis 19.39 10.70 37 486362 20146 110082754
Muscle disorder 19.34 10.70 69 486330 6603 110096297
Impaired work ability 19.32 10.70 56 486343 26363 110076537
Victim of crime 19.32 10.70 27 486372 1356 110101544
Tendon rupture 19.32 10.70 20 486379 14058 110088842
Embolism 19.29 10.70 26 486373 16263 110086637
Aplasia pure red cell 19.24 10.70 9 486390 9569 110093331
Intermittent explosive disorder 19.23 10.70 5 486394 4 110102896
Breast engorgement 19.18 10.70 8 486391 55 110102845
Hallucination, tactile 19.17 10.70 23 486376 992 110101908
Blood osmolarity increased 19.17 10.70 21 486378 820 110102080
Enthesopathy 19.16 10.70 16 486383 12462 110090438
Polyp 19.10 10.70 10 486389 9970 110092930
Wrong patient 19.09 10.70 28 486371 1471 110101429
Laryngitis 19.07 10.70 277 486122 42134 110060766
Arthritis bacterial 19.06 10.70 12 486387 10808 110092092
Anal abscess 19.04 10.70 14 486385 11624 110091276
Ischaemic stroke 19.03 10.70 105 486294 41158 110061742
Pathological fracture 19.01 10.70 15 486384 12017 110090883
Hyperchloraemia 19.00 10.70 26 486373 1280 110101620
Faeces soft 18.98 10.70 13 486386 11197 110091703
Bone lesion 18.96 10.70 4 486395 7083 110095817
Inflammation 18.95 10.70 677 485722 192561 109910339
Forced expiratory volume decreased 18.91 10.70 18 486381 13158 110089742
Swollen joint count 18.90 10.70 82 486317 8592 110094308
Postmortem blood drug level increased 18.89 10.70 25 486374 1192 110101708
Toxic leukoencephalopathy 18.87 10.70 29 486370 1588 110101312
Portal vein thrombosis 18.85 10.70 4 486395 7054 110095846
Oropharyngeal discomfort 18.82 10.70 11 486388 10316 110092584
Benign prostatic hyperplasia 18.80 10.70 32 486367 18202 110084698
Pneumatosis intestinalis 18.76 10.70 7 486392 8522 110094378
Haemothorax 18.74 10.70 4 486395 7027 110095873
Lactic acidosis 18.73 10.70 291 486108 92520 110010380
Device leakage 18.62 10.70 26 486373 16022 110086878
Respiratory acidosis 18.46 10.70 114 486285 13712 110089188
Suture rupture 18.37 10.70 19 486380 694 110102206
IVth nerve disorder 18.35 10.70 6 486393 18 110102882
Fear of weight gain 18.35 10.70 6 486393 18 110102882
Social problem 18.31 10.70 31 486368 1843 110101057
Diabetic ketoacidosis 18.25 10.70 273 486126 41785 110061115
Rapid eye movement sleep behaviour disorder 18.24 10.70 18 486381 621 110102279
Skin papilloma 18.23 10.70 4 486395 6892 110096008
Visceral pain 18.23 10.70 10 486389 134 110102766
Scleroderma 18.20 10.70 3 486396 6338 110096562
Faecal vomiting 18.16 10.70 28 486371 1538 110101362
Encephalitis toxic 18.14 10.70 13 486386 285 110102615
Discomfort 18.11 10.70 1135 485264 213572 109889328
Hyperkeratosis 18.07 10.70 9 486390 9230 110093670
Spinal disorder 18.06 10.70 15 486384 11713 110091187
Lichenoid keratosis 18.05 10.70 3 486396 6299 110096601
Anhedonia 18.02 10.70 123 486276 15305 110087595
Mouth swelling 18.01 10.70 5 486394 7349 110095551
Distractibility 17.98 10.70 21 486378 880 110102020
Persistent depressive disorder 17.96 10.70 27 486372 1450 110101450
Product preparation error 17.91 10.70 13 486386 10866 110092034
Upper respiratory tract infection 17.90 10.70 440 485959 130888 109972012
Pericardial effusion 17.87 10.70 163 486236 57054 110045846
Coronary artery occlusion 17.86 10.70 26 486373 15746 110087154
Temperature intolerance 17.84 10.70 21 486378 13929 110088971
Type 1 diabetes mellitus 17.82 10.70 83 486316 8964 110093936
Subdural haematoma 17.80 10.70 91 486308 36363 110066537
Ovarian cyst 17.78 10.70 21 486378 13909 110088991
Thermal burn 17.78 10.70 76 486323 7912 110094988
Pulmonary function test decreased 17.75 10.70 8 486391 8692 110094208
Tooth fracture 17.74 10.70 19 486380 13148 110089752
Buccoglossal syndrome 17.72 10.70 4 486395 0 110102900
Antidepressant drug level 17.72 10.70 4 486395 0 110102900
Thyroid cancer 17.70 10.70 3 486396 6211 110096689
Abdominal discomfort 17.70 10.70 1491 484908 392367 109710533
Peripheral circulatory failure 17.65 10.70 30 486369 1789 110101111
Blood sodium increased 17.65 10.70 59 486340 5464 110097436
Somatic symptom disorder of pregnancy 17.64 10.70 9 486390 103 110102797
Catheterisation cardiac 17.61 10.70 3 486396 6188 110096712
Gastroenteritis viral 17.58 10.70 74 486325 31152 110071748
Infusion site pain 17.57 10.70 31 486368 17388 110085512
Delusion of reference 17.56 10.70 12 486387 243 110102657
Chromaturia 17.53 10.70 68 486331 29292 110073608
Drug abuser 17.48 10.70 58 486341 5351 110097549
Granuloma 17.45 10.70 10 486389 9480 110093420
Psychogenic tremor 17.44 10.70 6 486393 22 110102878
Lung infiltration 17.44 10.70 53 486346 24575 110078325
Aortic aneurysm 17.42 10.70 11 486388 9893 110093007
Glossodynia 17.35 10.70 1166 485233 220838 109882062
Infusion site swelling 17.33 10.70 11 486388 9866 110093034
Peripheral vascular disorder 17.31 10.70 8 486391 8568 110094332
Electrocardiogram ST segment elevation 17.28 10.70 83 486316 9077 110093823
Stoma site pain 17.26 10.70 31 486368 1932 110100968
Odynophagia 17.22 10.70 22 486377 14079 110088821
Labelled drug-food interaction medication error 17.17 10.70 11 486388 199 110102701
Hyperarousal 17.05 10.70 7 486392 46 110102854
Duodenal ulcer haemorrhage 17.01 10.70 7 486392 8030 110094870
Pharyngitis streptococcal 16.97 10.70 20 486379 13257 110089643
Hyperaesthesia 16.95 10.70 24 486375 14703 110088197
Parkinsonism hyperpyrexia syndrome 16.88 10.70 17 486382 601 110102299
Dermatitis exfoliative 16.88 10.70 15 486384 11332 110091568
PO2 increased 16.86 10.70 27 486372 1532 110101368
Eosinopenia 16.85 10.70 9 486390 114 110102786
Immunosuppressant drug level increased 16.84 10.70 16 486383 11708 110091192
Aortic arteriosclerosis 16.83 10.70 14 486385 10924 110091976
Food craving 16.81 10.70 31 486368 1972 110100928
Aphthous ulcer 16.81 10.70 43 486356 21093 110081807
Myopathy 16.77 10.70 55 486344 24905 110077995
Congenital cerebrovascular anomaly 16.71 10.70 5 486394 10 110102890
Conjunctival abrasion 16.71 10.70 5 486394 10 110102890
Intervertebral discitis 16.66 10.70 5 486394 6985 110095915
Sleep disorder therapy 16.66 10.70 6 486393 7465 110095435
Non-small cell lung cancer 16.66 10.70 7 486392 7928 110094972
Claustrophobia 16.61 10.70 27 486372 1552 110101348
Infusion site extravasation 16.57 10.70 16 486383 11618 110091282
Anti-cyclic citrullinated peptide antibody 16.56 10.70 147 486252 19817 110083083
Disease recurrence 16.55 10.70 179 486220 60605 110042295
Thrombocytosis 16.53 10.70 13 486386 10431 110092469
Cortisol increased 16.52 10.70 17 486382 617 110102283
Catheter site pain 16.52 10.70 4 486395 6442 110096458
Pain of skin 16.52 10.70 40 486359 19989 110082911
Crepitations 16.51 10.70 14 486385 10821 110092079
Polymyalgia rheumatica 16.50 10.70 4 486395 6438 110096462
Oedema peripheral 16.50 10.70 1233 485166 327427 109775473
Visual acuity reduced 16.46 10.70 79 486320 32094 110070806
Lipase increased 16.44 10.70 36 486363 18636 110084264
C-reactive protein increased 16.37 10.70 787 485612 217132 109885768
Paranasal sinus discomfort 16.36 10.70 4 486395 6401 110096499
Poriomania 16.35 10.70 11 486388 217 110102683
Diastolic hypotension 16.34 10.70 13 486386 335 110102565
Central nervous system lesion 16.31 10.70 27 486372 15526 110087374
Faecalith 16.30 10.70 6 486393 28 110102872
Asterixis 16.20 10.70 40 486359 3118 110099782
Oral infection 16.20 10.70 4 486395 6357 110096543
Aortic valve stenosis 16.16 10.70 4 486395 6346 110096554
Tooth extraction 16.14 10.70 20 486379 12971 110089929
Eructation 16.09 10.70 23 486376 14034 110088866
Pneumonia fungal 16.05 10.70 25 486374 14729 110088171
Encephalitis 16.03 10.70 37 486362 18802 110084098
Formication 16.02 10.70 58 486341 5590 110097310
Superinfection 15.95 10.70 3 486396 5760 110097140
Gastrointestinal infection 15.94 10.70 23 486376 13982 110088918
Asocial behaviour 15.88 10.70 8 486391 89 110102811
Renal disorder 15.87 10.70 140 486259 49339 110053561
Intentional dose omission 15.86 10.70 41 486358 20039 110082861
Vascular dementia 15.85 10.70 20 486379 909 110101991
Sleep disorder due to general medical condition, insomnia type 15.82 10.70 591 485808 105052 109997848
Drug tolerance 15.82 10.70 126 486273 16459 110086441
Pleurisy 15.75 10.70 18 486381 12098 110090802
Spinal operation 15.73 10.70 15 486384 10957 110091943
Painful erection 15.71 10.70 11 486388 232 110102668
Anosmia 15.71 10.70 19 486380 12453 110090447
Body height decreased 15.67 10.70 14 486385 10549 110092351
Renal function test abnormal 15.65 10.70 10 486389 8936 110093964
Bladder prolapse 15.63 10.70 25 486374 1417 110101483
Exercise tolerance decreased 15.61 10.70 18 486381 12049 110090851
Brachial plexopathy 15.60 10.70 12 486387 294 110102606
Paraplegia 15.59 10.70 4 486395 6196 110096704
Flashback 15.58 10.70 14 486385 428 110102472
Dysphemia 15.55 10.70 46 486353 3991 110098909
Diastolic dysfunction 15.52 10.70 19 486380 12385 110090515
Breast discharge 15.50 10.70 20 486379 930 110101970
Lip oedema 15.48 10.70 7 486392 7593 110095307
Confabulation 15.47 10.70 15 486384 506 110102394
Brachial plexus injury 15.46 10.70 9 486390 136 110102764
Electroconvulsive therapy 15.42 10.70 8 486391 95 110102805
Conduction disorder 15.42 10.70 46 486353 4009 110098891
Eye disorder 15.37 10.70 70 486329 28836 110074064
Conjunctival haemorrhage 15.36 10.70 5 486394 6628 110096272
Duodenal ulcer 15.29 10.70 40 486359 19474 110083426
Stress cardiomyopathy 15.17 10.70 29 486370 15777 110087123
Hypernatraemia 15.15 10.70 132 486267 17701 110085199
Jaundice 15.12 10.70 177 486222 59059 110043841
Device kink 15.09 10.70 30 486369 2019 110100881
Hyponatraemic coma 15.08 10.70 7 486392 64 110102836
Blood immunoglobulin E increased 15.07 10.70 7 486392 7475 110095425
Hand deformity 15.07 10.70 1136 485263 217370 109885530
Systemic candida 15.06 10.70 13 486386 9961 110092939
Eye discharge 15.02 10.70 10 486389 8744 110094156
Stomatitis 15.01 10.70 1005 485394 269237 109833663
Electrocardiogram T wave inversion 15.00 10.70 57 486342 5623 110097277
Defaecation urgency 15.00 10.70 10 486389 8737 110094163
Coronavirus infection 14.95 10.70 12 486387 9533 110093367
Lymphadenopathy mediastinal 14.87 10.70 3 486396 5481 110097419
Nephrogenic systemic fibrosis 14.86 10.70 3 486396 5480 110097420
Skin hyperpigmentation 14.83 10.70 10 486389 8686 110094214
Obsessive-compulsive symptom 14.83 10.70 12 486387 317 110102583
Electroencephalogram abnormal 14.73 10.70 60 486339 6113 110096787
Chronic lymphocytic leukaemia 14.72 10.70 4 486395 5964 110096936
Gastrointestinal inflammation 14.72 10.70 12 486387 9457 110093443
Phaeochromocytoma malignant 14.72 10.70 7 486392 68 110102832
Drug ineffective for unapproved indication 14.71 10.70 342 486057 102496 110000404
Cyclothymic disorder 14.71 10.70 11 486388 258 110102642
Staphylococcus test positive 14.69 10.70 7 486392 7363 110095537
Verbal abuse 14.67 10.70 12 486387 322 110102578
Blood pressure abnormal 14.66 10.70 50 486349 22374 110080526
Salmonella bacteraemia 14.66 10.70 16 486383 622 110102278
Portal hypertension 14.64 10.70 10 486389 8627 110094273
Gastrointestinal necrosis 14.64 10.70 63 486336 6577 110096323
Lack of spontaneous speech 14.64 10.70 11 486388 260 110102640
False positive investigation result 14.63 10.70 24 486375 1390 110101510
Penile haemorrhage 14.63 10.70 19 486380 889 110102011
Iridocyclitis 14.58 10.70 3 486396 5405 110097495
Thrombotic thrombocytopenic purpura 14.57 10.70 66 486333 7045 110095855
Non-cardiac chest pain 14.55 10.70 14 486385 10184 110092716
Acne 14.55 10.70 87 486312 33433 110069467
Rabies 14.54 10.70 6 486393 40 110102860
Hanging 14.53 10.70 10 486389 205 110102695
Hepatomegaly 14.52 10.70 47 486352 21367 110081533
Ankle fracture 14.50 10.70 42 486357 19777 110083123
Induced abortion failed 14.49 10.70 9 486390 154 110102746
Injection site extravasation 14.47 10.70 14 486385 10155 110092745
Pharyngeal swelling 14.46 10.70 19 486380 12013 110090887
Retrograde ejaculation 14.46 10.70 13 486386 398 110102502
Liver abscess 14.45 10.70 8 486391 7731 110095169
Breast cancer stage II 14.44 10.70 184 486215 27191 110075709
CADASIL 14.42 10.70 6 486393 41 110102859
Pupillary disorder 14.39 10.70 16 486383 635 110102265
Analgesic therapy 14.39 10.70 7 486392 7277 110095623
Unmasking of previously unidentified disease 14.37 10.70 36 486363 2832 110100068
Cleft palate 14.32 10.70 13 486386 403 110102497
Abortion spontaneous 14.28 10.70 221 486178 34061 110068839
Limb discomfort 14.28 10.70 113 486286 40741 110062159
Overlap syndrome 14.24 10.70 78 486321 8981 110093919
Onychoclasis 14.23 10.70 7 486392 7230 110095670
Haemorrhoidal haemorrhage 14.22 10.70 9 486390 8084 110094816
Flat affect 14.22 10.70 33 486366 2472 110100428
Blood glucose increased 14.21 10.70 716 485683 131780 109971120
Drug dispensed to wrong patient 14.19 10.70 17 486382 732 110102168
Hepatic lesion 14.18 10.70 10 486389 8483 110094417
Immune-mediated lung disease 14.17 10.70 3 486396 5300 110097600
Cancer pain 14.17 10.70 6 486393 6766 110096134
Cholestasis 14.16 10.70 199 486200 64319 110038581
Electrocardiogram QT interval 14.15 10.70 11 486388 274 110102626
Enterobacter infection 14.14 10.70 4 486395 5807 110097093
Patient elopement 14.12 10.70 12 486387 340 110102560
Eyelid ptosis 14.10 10.70 23 486376 13304 110089596
Polymerase chain reaction 14.09 10.70 8 486391 115 110102785
Blood loss anaemia 14.08 10.70 37 486362 17988 110084912
Carotid artery stenosis 14.07 10.70 12 486387 9251 110093649
Cyanosis 14.07 10.70 196 486203 29545 110073355
Female sexual dysfunction 14.06 10.70 6 486393 44 110102856
Ejaculation disorder 14.04 10.70 15 486384 569 110102331
Carbon monoxide poisoning 14.03 10.70 12 486387 343 110102557
Staphylococcal bacteraemia 14.02 10.70 33 486366 16655 110086245
Nerve compression 13.99 10.70 17 486382 11120 110091780
Gastrointestinal sounds abnormal 13.97 10.70 58 486341 5960 110096940
Throat tightness 13.97 10.70 88 486311 33401 110069499
Malnutrition 13.95 10.70 67 486332 27212 110075688
B-cell lymphoma 13.95 10.70 7 486392 7147 110095753
Serum ferritin increased 13.94 10.70 19 486380 11828 110091072
Neoplasm recurrence 13.90 10.70 3 486396 5229 110097671
Incorrect product administration duration 13.89 10.70 45 486354 20453 110082447
Total cholesterol/HDL ratio abnormal 13.88 10.70 7 486392 78 110102822
Hyperdynamic left ventricle 13.87 10.70 15 486384 577 110102323
Joint destruction 13.84 10.70 89 486310 10854 110092046
Ankylosing spondylitis 13.83 10.70 30 486369 15582 110087318
Neuroleptic-induced deficit syndrome 13.82 10.70 5 486394 22 110102878
Vitamin D deficiency 13.81 10.70 39 486360 18513 110084387
Tourette's disorder 13.81 10.70 7 486392 79 110102821
Device issue 13.77 10.70 92 486307 34443 110068457
Immune-mediated myositis 13.74 10.70 5 486394 6181 110096719
Medical device site injury 13.71 10.70 4 486395 7 110102893
Feeling abnormal 13.70 10.70 652 485747 180059 109922841
Scar 13.69 10.70 34 486365 16847 110086053
Cataplexy 13.69 10.70 21 486378 1148 110101752
Hyperthermia malignant 13.67 10.70 43 486356 3857 110099043
Urosepsis 13.64 10.70 79 486320 30596 110072304
Injection site discolouration 13.58 10.70 12 486387 9091 110093809
Rhythm idioventricular 13.55 10.70 17 486382 768 110102132
Escherichia urinary tract infection 13.55 10.70 32 486367 16130 110086770
Dermatitis exfoliative generalised 13.52 10.70 17 486382 10955 110091945
Indifference 13.52 10.70 12 486387 361 110102539
Blood cholesterol decreased 13.51 10.70 34 486365 2682 110100218
CYP2D6 polymorphism 13.50 10.70 7 486392 83 110102817
Vitamin K decreased 13.50 10.70 7 486392 83 110102817
Pulmonary arterial pressure increased 13.50 10.70 3 486396 5124 110097776
Eosinophilic pleural effusion 13.47 10.70 14 486385 514 110102386
Subcutaneous drug absorption impaired 13.45 10.70 68 486331 7591 110095309
Soft tissue infection 13.42 10.70 3 486396 5104 110097796
Gait inability 13.42 10.70 731 485668 135645 109967255
Systemic infection 13.42 10.70 14 486385 9805 110093095
Autoimmune haemolytic anaemia 13.42 10.70 16 486383 10551 110092349
Stoma site induration 13.40 10.70 6 486393 50 110102850
Trigger finger 13.37 10.70 3 486396 5089 110097811
Eosinophilic cellulitis 13.36 10.70 11 486388 298 110102602
Wrist fracture 13.36 10.70 27 486372 14390 110088510
Secretion discharge 13.33 10.70 45 486354 20199 110082701
Salivary gland calculus 13.33 10.70 11 486388 299 110102601
Blood pressure systolic abnormal 13.32 10.70 60 486339 24790 110078110
Erotomanic delusion 13.29 10.70 3 486396 0 110102900
Scrotal irritation 13.29 10.70 3 486396 0 110102900
Streptococcal sepsis 13.29 10.70 3 486396 5069 110097831
Petechiae 13.29 10.70 55 486344 23262 110079638
Oesophagitis 13.28 10.70 73 486326 28642 110074258
Breast cancer stage I 13.28 10.70 8 486391 7379 110095521
Irritable bowel syndrome 13.28 10.70 865 485534 163350 109939550
Infusion site erythema 13.26 10.70 20 486379 11939 110090961
Hyperthyroidism 13.20 10.70 75 486324 29186 110073714
Encopresis 13.18 10.70 8 486391 131 110102769
Wrong product administered 13.17 10.70 88 486311 10872 110092028
Stoma site extravasation 13.17 10.70 12 486387 374 110102526
Lung consolidation 13.15 10.70 16 486383 10460 110092440
Immunodeficiency 13.12 10.70 242 486157 38596 110064304
Gastric ulcer haemorrhage 13.12 10.70 15 486384 10079 110092821
Total lung capacity decreased 13.09 10.70 64 486335 7050 110095850
Intrusive thoughts 13.07 10.70 16 486383 705 110102195
Hypovolaemia 13.07 10.70 50 486349 21624 110081276
Discoloured vomit 13.05 10.70 28 486371 1989 110100911
Propulsive gait 13.05 10.70 4 486395 9 110102891
Schizotypal personality disorder 13.05 10.70 4 486395 9 110102891
Infusion site pruritus 13.05 10.70 3 486396 5005 110097895
Epidermolysis bullosa 13.03 10.70 12 486387 379 110102521
Idiopathic pulmonary fibrosis 13.03 10.70 3 486396 5001 110097899
Selective mutism 13.01 10.70 7 486392 90 110102810
Gastrointestinal pain 12.99 10.70 20 486379 11840 110091060
Bronchiolitis 12.97 10.70 4 486395 5489 110097411
Drug therapy 12.96 10.70 8 486391 7283 110095617
Muscle contractions involuntary 12.92 10.70 46 486353 4398 110098502
Tooth abscess 12.90 10.70 41 486358 18748 110084152
Glaucoma 12.90 10.70 53 486346 22464 110080436
Megacolon 12.89 10.70 45 486354 4260 110098640
Poor quality sleep 12.87 10.70 184 486215 27893 110075007
Bone marrow eosinophilic leukocyte count increased 12.84 10.70 5 486394 28 110102872
Distal intestinal obstruction syndrome 12.84 10.70 19 486380 1006 110101894
Fungal skin infection 12.82 10.70 8 486391 7241 110095659
Nerve injury 12.79 10.70 17 486382 10696 110092204
Cheilitis 12.75 10.70 6 486393 6359 110096541
Gingivitis 12.74 10.70 16 486383 10315 110092585
Anamnestic reaction 12.73 10.70 6 486393 57 110102843
Blood pressure inadequately controlled 12.72 10.70 9 486390 7624 110095276
Varices oesophageal 12.71 10.70 8 486391 7207 110095693
Abdominal abscess 12.71 10.70 12 486387 8807 110094093
Blood lactate dehydrogenase increased 12.70 10.70 129 486270 44205 110058695
Carotid artery occlusion 12.67 10.70 14 486385 9551 110093349
Folliculitis 12.65 10.70 878 485521 166775 109936125
Atrial tachycardia 12.64 10.70 13 486386 9165 110093735
Metastatic neoplasm 12.62 10.70 5 486394 5868 110097032
Keratosis follicular 12.56 10.70 5 486394 30 110102870
Learning disability 12.53 10.70 9 486390 198 110102702
Body temperature decreased 12.52 10.70 103 486296 36832 110066068
Klebsiella bacteraemia 12.52 10.70 3 486396 4866 110098034
Overweight 12.51 10.70 59 486340 6405 110096495
Flail chest 12.49 10.70 7 486392 98 110102802
Facet joint syndrome 12.48 10.70 533 485866 96295 110006605
Meningitis aseptic 12.47 10.70 15 486384 9855 110093045
Spinal cord compression 12.46 10.70 9 486390 7543 110095357
Fluid intake restriction 12.46 10.70 6 486393 60 110102840
Rash morbilliform 12.45 10.70 10 486389 7941 110094959
Photosensitivity reaction 12.42 10.70 64 486335 25525 110077375
Sleep talking 12.42 10.70 21 486378 1247 110101653
Acute myopia 12.41 10.70 9 486390 201 110102699
Gingival swelling 12.37 10.70 4 486395 5326 110097574
Thrombosis in device 12.36 10.70 4 486395 5323 110097577
Eye injury 12.34 10.70 67 486332 7688 110095212
Pregnancy 12.33 10.70 303 486096 50764 110052136
Delusion of replacement 12.30 10.70 10 486389 266 110102634
Feminisation acquired 12.29 10.70 5 486394 32 110102868
Swollen tongue 12.27 10.70 189 486210 60173 110042727
Agitated depression 12.25 10.70 14 486385 573 110102327
Lower gastrointestinal haemorrhage 12.24 10.70 41 486358 18445 110084455
Blindness unilateral 12.23 10.70 15 486384 9771 110093129
Aphasia 12.20 10.70 343 486056 58654 110044246
Sputum increased 12.19 10.70 5 486394 5746 110097154
Electrocardiogram ST segment depression 12.19 10.70 52 486347 5409 110097491
Cerebral atrophy 12.18 10.70 75 486324 9010 110093890
Hyperlactacidaemia 12.14 10.70 70 486329 8216 110094684
Ulcerative keratitis 12.13 10.70 3 486396 4763 110098137
Frontotemporal dementia 12.13 10.70 15 486384 668 110102232
International normalised ratio decreased 12.12 10.70 11 486388 8225 110094675
Incorrect dose administered 12.09 10.70 355 486044 103286 109999614
Renal tubular disorder 12.07 10.70 9 486390 7420 110095480
Delirium febrile 12.05 10.70 6 486393 65 110102835
Adjustment disorder 12.02 10.70 18 486381 10777 110092123
Mass 12.02 10.70 45 486354 19585 110083315
Visual field defect 12.01 10.70 16 486383 10056 110092844
Paralysis 11.99 10.70 113 486286 15487 110087413
Aphonia 11.99 10.70 24 486375 12836 110090064
Oxygen consumption increased 11.96 10.70 5 486394 5680 110097220
Subdural haemorrhage 11.93 10.70 7 486392 6551 110096349
Central nervous system injury 11.93 10.70 8 486391 157 110102743
Joint dislocation 11.89 10.70 214 486185 33976 110068924
Postoperative respiratory failure 11.86 10.70 9 486390 216 110102684
Fear of injection 11.85 10.70 13 486386 8898 110094002
Fungaemia 11.80 10.70 6 486393 6080 110096820
Alopecia 11.80 10.70 1414 484985 363339 109739561
Ligament sprain 11.80 10.70 34 486365 16034 110086866
Increased tendency to bruise 11.79 10.70 21 486378 11737 110091163
Urine sodium increased 11.79 10.70 9 486390 218 110102682
Mixed dementia 11.78 10.70 10 486389 283 110102617
Oesophageal stenosis 11.77 10.70 4 486395 5161 110097739
Liver function test abnormal 11.71 10.70 223 486176 68727 110034173
Acidosis 11.70 10.70 151 486248 22380 110080520
Joint noise 11.69 10.70 4 486395 5139 110097761
Red cell distribution width increased 11.68 10.70 39 486360 17563 110085337
Glabellar reflex abnormal 11.68 10.70 5 486394 37 110102863
Acute myeloid leukaemia recurrent 11.68 10.70 4 486395 5135 110097765
Emphysema 11.64 10.70 46 486353 19710 110083190
Oesophageal pain 11.63 10.70 4 486395 5121 110097779
Systemic inflammatory response syndrome 11.60 10.70 25 486374 13018 110089882
Blood pressure diastolic increased 11.59 10.70 43 486356 18764 110084136
Thyroid mass 11.58 10.70 4 486395 5109 110097791
Crush injury 11.56 10.70 4 486395 15 110102885
Metabolic alkalosis 11.51 10.70 52 486347 5543 110097357
Antinuclear antibody positive 11.51 10.70 14 486385 9154 110093746
Lactate pyruvate ratio increased 11.51 10.70 6 486393 72 110102828
Ischaemic cardiomyopathy 11.43 10.70 11 486388 8000 110094900
Blood creatinine decreased 11.43 10.70 14 486385 9123 110093777
Nephrogenic anaemia 11.42 10.70 3 486396 4574 110098326
Vitreous floaters 11.42 10.70 14 486385 9120 110093780
Soliloquy 11.40 10.70 18 486381 1009 110101891
Catheter site infection 11.40 10.70 11 486388 7989 110094911
Malignant polyp 11.38 10.70 8 486391 170 110102730
Blepharospasm 11.37 10.70 319 486080 54532 110048368
Gait deviation 11.36 10.70 7 486392 118 110102782
Parkinsonian crisis 11.36 10.70 4 486395 16 110102884
Embolic stroke 11.36 10.70 13 486386 8730 110094170
CSWS syndrome 11.35 10.70 5 486394 40 110102860
Gait apraxia 11.35 10.70 5 486394 40 110102860
Blepharitis 11.33 10.70 3 486396 4549 110098351
Pneumomediastinum 11.30 10.70 4 486395 5032 110097868
Dyspnoea at rest 11.29 10.70 12 486387 8334 110094566
Radiation pneumonitis 11.27 10.70 3 486396 4533 110098367
Dysmetropsia 11.26 10.70 7 486392 120 110102780
Food intolerance 11.23 10.70 3 486396 4524 110098376
Tonic posturing 11.23 10.70 3 486396 3 110102897
22q11.2 deletion syndrome 11.23 10.70 3 486396 3 110102897
Lack of satiety 11.23 10.70 3 486396 3 110102897
Coronary arterial stent insertion 11.21 10.70 6 486393 5909 110096991
Dissociative amnesia 11.21 10.70 7 486392 121 110102779
Pulmonary thrombosis 11.18 10.70 28 486371 13835 110089065
Papule 11.18 10.70 17 486382 10116 110092784
Iron deficiency anaemia 11.16 10.70 87 486312 31472 110071428
Lung perforation 11.16 10.70 7 486392 122 110102778
Gestational hypertension 11.15 10.70 28 486371 2206 110100694
Drug effective for unapproved indication 11.13 10.70 29 486370 14138 110088762
Glycosuria 11.13 10.70 31 486368 2599 110100301
Stoma site odour 11.11 10.70 7 486392 123 110102777
Large intestine infection 11.10 10.70 3 486396 4489 110098411
Therapeutic response changed 11.10 10.70 23 486376 1595 110101305
Bronchial aspiration procedure 11.10 10.70 10 486389 307 110102593
Catheter site haemorrhage 11.10 10.70 6 486393 5874 110097026
Cardiac pacemaker insertion 11.08 10.70 7 486392 6294 110096606
Protein urine present 11.08 10.70 21 486378 11463 110091437
Mouth haemorrhage 11.07 10.70 27 486372 13461 110089439
Pulmonary pain 11.06 10.70 7 486392 6286 110096614
Herpes virus infection 11.05 10.70 13 486386 8625 110094275
Pharyngeal dystonia 11.04 10.70 5 486394 43 110102857
Growth hormone deficiency 11.03 10.70 12 486387 465 110102435
Burnout syndrome 11.02 10.70 11 486388 385 110102515
Abnormal clotting factor 10.98 10.70 8 486391 180 110102720
Vein disorder 10.98 10.70 7 486392 6263 110096637
Otitis media 10.98 10.70 10 486389 7466 110095434
Purulent discharge 10.98 10.70 9 486390 7074 110095826
Accidental exposure to product by child 10.97 10.70 35 486364 3163 110099737
Bronchopulmonary aspergillosis allergic 10.95 10.70 69 486330 8357 110094543
Immune-mediated hepatic disorder 10.95 10.70 3 486396 4447 110098453
Pemphigoid 10.91 10.70 47 486352 19660 110083240
Acute hepatic failure 10.91 10.70 105 486294 36363 110066537
Respiratory alkalosis 10.91 10.70 52 486347 5669 110097231
Subcutaneous abscess 10.90 10.70 15 486384 9302 110093598
Pupillary light reflex tests abnormal 10.90 10.70 11 486388 390 110102510
Heart rate increased 10.89 10.70 519 485880 143315 109959585
Invasive ductal breast carcinoma 10.87 10.70 8 486391 6638 110096262
Foaming at mouth 10.86 10.70 28 486371 2242 110100658
Compression fracture 10.85 10.70 15 486384 9284 110093616
Dermatitis bullous 10.85 10.70 40 486359 17489 110085411
Pneumonia salmonella 10.83 10.70 6 486393 82 110102818
Clinomania 10.83 10.70 6 486393 82 110102818
Product counterfeit 10.83 10.70 10 486389 317 110102583
Normochromic normocytic anaemia 10.83 10.70 26 486373 13031 110089869
Sleep disorder due to general medical condition, hypersomnia type 10.81 10.70 26 486373 1993 110100907
Dermatomyositis 10.78 10.70 3 486396 4403 110098497
Hiatus hernia 10.78 10.70 74 486325 27532 110075368
Electrolyte substitution therapy 10.77 10.70 3 486396 4 110102896
Intra-abdominal haemorrhage 10.76 10.70 5 486394 5337 110097563
Ovarian cancer 10.75 10.70 3 486396 4393 110098507
Non-high-density lipoprotein cholesterol increased 10.74 10.70 11 486388 397 110102503
Linear IgA disease 10.72 10.70 3 486396 4386 110098514

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypertonia neonatal 31.44 25.70 44 2927 339 110643
Meconium aspiration syndrome 31.27 25.70 19 2952 37 110945
Withdrawal syndrome 29.16 25.70 29 2942 147 110835

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014150 Antipsychotic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:37887 adrenergic antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:65191 second generation antipsychotic

Related Drugs by ATC class:

N05AH Diazepines, oxazepines, thiazepines and oxepines 6 drugs
asenapineclotiapineclozapineloxapineolanzapinesamidorphan

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Histone H1.0 Nuclear other Ki 8 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
Transporter Transporter Ki 6.17 CHEMBL

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0123091 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEMBL3188993 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US
BGL0JSY5SI INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0280 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0281 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0282 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0283 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0284 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1180 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1181 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1182 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1183 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1184 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 33 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8470 TABLET, FILM COATED 25 mg ORAL ANDA 30 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8471 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections