quetiapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3276.38 10.37 3059 170470 135142 53040395
Toxicity to various agents 3026.76 10.37 3640 169889 215958 52959579
Drug abuse 2601.84 10.37 1956 171573 63570 53111967
Intentional overdose 2553.35 10.37 1954 171575 65251 53110286
Sopor 2338.37 10.37 1211 172318 19873 53155664
Suicide attempt 2334.74 10.37 1748 171781 56420 53119117
Intentional self-injury 1436.85 10.37 941 172588 24343 53151194
Overdose 1396.27 10.37 1735 171794 106001 53069536
Neuroleptic malignant syndrome 1293.12 10.37 677 172852 11356 53164181
Sedation 1034.58 10.37 821 172708 28854 53146683
Drug interaction 1023.58 10.37 2223 171306 217106 52958431
Electrocardiogram QT prolonged 930.87 10.37 1029 172500 55374 53120163
Somnolence 868.92 10.37 1775 171754 165959 53009578
Coma 820.35 10.37 1008 172521 60775 53114762
Tardive dyskinesia 815.89 10.37 436 173093 7634 53167903
Dystonia 799.56 10.37 509 173020 12512 53163025
Suicidal ideation 649.63 10.37 889 172640 59622 53115915
Akathisia 633.08 10.37 377 173152 8194 53167343
Schizophrenia 621.61 10.37 398 173131 9881 53165656
Depressed level of consciousness 616.78 10.37 821 172708 53607 53121930
Psychotic disorder 614.49 10.37 560 172969 23825 53151712
Agitation 582.60 10.37 830 172699 57796 53117741
Dyskinesia 574.32 10.37 609 172920 31224 53144313
Gestational diabetes 563.72 10.37 342 173187 7697 53167840
Extrapyramidal disorder 546.91 10.37 395 173134 12007 53163530
Mania 538.25 10.37 384 173145 11445 53164092
Rheumatoid arthritis 479.30 10.37 212 173317 314319 52861218
Diabetes mellitus 470.45 10.37 718 172811 53181 53122356
Blood prolactin abnormal 456.94 10.37 193 173336 1928 53173609
Sexual dysfunction 438.66 10.37 215 173314 3111 53172426
Arthralgia 437.80 10.37 472 173057 439311 52736226
Tachycardia 411.08 10.37 1013 172516 107199 53068338
Parkinsonism 401.82 10.37 289 173240 8724 53166813
Serotonin syndrome 396.56 10.37 459 173070 25947 53149590
Diarrhoea 396.15 10.37 910 172619 624636 52550901
Poisoning 386.44 10.37 337 173192 13513 53162024
Anosognosia 373.41 10.37 169 173360 2020 53173517
Pain 360.36 10.37 871 172658 587527 52588010
Muscle rigidity 354.39 10.37 289 173240 10552 53164985
Joint swelling 354.28 10.37 160 173369 234478 52941059
Disturbance in social behaviour 344.30 10.37 173 173356 2648 53172889
Delusion 342.72 10.37 296 173233 11713 53163824
Hallucination 319.47 10.37 604 172925 53234 53122303
Cardio-respiratory arrest 319.14 10.37 635 172894 58123 53117414
Hallucination, auditory 315.52 10.37 280 173249 11493 53164044
Aggression 307.36 10.37 380 173149 23023 53152514
Altered state of consciousness 301.92 10.37 388 173141 24448 53151089
Rash 300.91 10.37 626 172903 445565 52729972
Dyspnoea 299.71 10.37 947 172582 585285 52590252
Metabolic disorder 286.36 10.37 193 173336 5234 53170303
Delirium 280.27 10.37 492 173037 40937 53134600
Restlessness 274.94 10.37 395 173134 27692 53147845
Bipolar disorder 274.89 10.37 216 173313 7470 53168067
Respiratory arrest 274.68 10.37 434 173095 33106 53142431
Fatigue 264.81 10.37 1352 172177 729154 52446383
Bezoar 263.92 10.37 117 173412 1327 53174210
Hypomania 253.73 10.37 172 173357 4710 53170827
Bradyphrenia 252.92 10.37 195 173334 6555 53168982
Personality change 250.81 10.37 186 173343 5891 53169646
Poisoning deliberate 249.10 10.37 215 173314 8498 53167039
Abnormal behaviour 246.22 10.37 329 173200 21537 53154000
Cardiac arrest 241.81 10.37 762 172767 92905 53082632
Peripheral swelling 241.51 10.37 190 173339 205918 52969619
Confusional state 239.31 10.37 1255 172274 192966 52982571
Seizure 238.13 10.37 942 172587 128567 53046970
Tremor 238.03 10.37 923 172606 124813 53050724
Sinusitis 237.52 10.37 126 173403 168438 53007099
Loss of consciousness 234.90 10.37 861 172668 113351 53062186
Exposure during pregnancy 234.27 10.37 914 172615 123946 53051591
Nasopharyngitis 225.62 10.37 177 173352 192118 52983419
Psychomotor hyperactivity 223.81 10.37 216 173313 9880 53165657
Pruritus 216.20 10.37 391 173138 293441 52882096
Drug hypersensitivity 214.51 10.37 332 173197 264910 52910627
Mydriasis 211.88 10.37 221 173308 11105 53164432
Pain in extremity 210.00 10.37 379 173150 284671 52890866
Galactorrhoea 208.22 10.37 141 173388 3854 53171683
Hypersensitivity 206.94 10.37 228 173301 210437 52965100
Swelling 204.58 10.37 192 173337 190913 52984624
Cough 201.62 10.37 328 173201 256565 52918972
Intentional product misuse 199.78 10.37 474 173055 48918 53126619
Drug intolerance 197.91 10.37 226 173303 205267 52970270
Sinus tachycardia 195.73 10.37 307 173222 23265 53152272
Synovitis 194.27 10.37 55 173474 107838 53067699
Febrile neutropenia 191.73 10.37 52 173477 104884 53070653
Metabolic syndrome 190.00 10.37 93 173436 1341 53174196
Anticholinergic syndrome 187.01 10.37 102 173427 1862 53173675
Infusion related reaction 186.15 10.37 141 173388 155816 53019721
Nausea 185.65 10.37 1573 171956 754518 52421019
Abdominal discomfort 182.24 10.37 273 173256 220789 52954748
Headache 179.31 10.37 1020 172509 535801 52639736
Stubbornness 174.60 10.37 56 173473 229 53175308
Hyperprolactinaemia 172.77 10.37 117 173412 3198 53172339
Anxiety 172.59 10.37 1163 172366 195541 52979996
Alopecia 170.81 10.37 314 173215 234269 52941268
Disorientation 170.43 10.37 388 173141 38971 53136566
Infection 169.49 10.37 186 173343 172019 53003518
Bradykinesia 168.01 10.37 128 173401 4225 53171312
Restless legs syndrome 166.75 10.37 241 173288 16982 53158555
Urinary retention 159.75 10.37 312 173217 28154 53147383
Labour complication 158.46 10.37 41 173488 57 53175480
Back pain 157.18 10.37 329 173200 233918 52941619
Malignant neoplasm progression 156.60 10.37 23 173506 71518 53104019
Hallucinations, mixed 156.28 10.37 123 173406 4263 53171274
Disturbance in attention 155.64 10.37 345 173184 34038 53141499
Disease progression 154.42 10.37 69 173460 101851 53073686
Diabetic coma 153.24 10.37 68 173461 773 53174764
Pneumonia 152.91 10.37 743 172786 406426 52769111
Paranoia 152.40 10.37 187 173342 11237 53164300
Treatment failure 149.51 10.37 119 173410 128284 53047253
Blood prolactin increased 149.28 10.37 106 173423 3133 53172404
Oculogyric crisis 149.27 10.37 80 173449 1408 53174129
Dysarthria 148.80 10.37 375 173154 40193 53135344
Hypotension 145.71 10.37 1362 172167 252714 52922823
Speech disorder 141.43 10.37 360 173169 38821 53136716
Stomatitis 134.37 10.37 76 173453 98082 53077455
Depression 133.78 10.37 1036 172493 182016 52993521
Hyperammonaemic encephalopathy 132.93 10.37 83 173446 1968 53173569
Irritability 131.64 10.37 303 173226 30650 53144887
Electrocardiogram QRS complex prolonged 131.34 10.37 125 173404 5617 53169920
Anaemia 129.85 10.37 463 173066 276255 52899282
Respiratory depression 128.09 10.37 182 173347 12624 53162913
Urticaria 126.92 10.37 153 173376 135732 53039805
Weight increased 126.06 10.37 1114 172415 203453 52972084
Drug ineffective 122.57 10.37 1898 171631 815347 52360190
Coma scale abnormal 120.87 10.37 114 173415 5064 53170473
Substance abuse 120.64 10.37 107 173422 4387 53171150
Orthostatic hypertension 120.07 10.37 43 173486 262 53175275
Antipsychotic drug level increased 119.75 10.37 94 173435 3245 53172292
Pleurothotonus 118.65 10.37 67 173462 1312 53174225
Depersonalisation/derealisation disorder 118.08 10.37 64 173465 1153 53174384
Obesity 118.02 10.37 202 173327 16460 53159077
Type 2 diabetes mellitus 117.44 10.37 294 173235 31376 53144161
Arthropathy 117.14 10.37 174 173355 141279 53034258
Herpes zoster 117.09 10.37 47 173482 73972 53101565
Unresponsive to stimuli 115.36 10.37 302 173227 33124 53142413
Cogwheel rigidity 114.90 10.37 71 173458 1652 53173885
Catatonia 114.08 10.37 99 173430 3941 53171596
Systemic lupus erythematosus 113.15 10.37 145 173384 125269 53050268
Lower respiratory tract infection 112.74 10.37 79 173450 90902 53084635
Withdrawal syndrome 112.51 10.37 215 173314 19086 53156451
Contraindicated product administered 112.15 10.37 167 173362 135462 53040075
Thinking abnormal 112.04 10.37 154 173375 10354 53165183
Impaired healing 111.41 10.37 35 173494 64170 53111367
Sepsis 111.00 10.37 191 173338 146238 53029299
Blood creatine phosphokinase increased 110.56 10.37 272 173257 28713 53146824
Cardiac failure congestive 107.91 10.37 86 173443 92671 53082866
Miosis 107.24 10.37 123 173406 6879 53168658
Therapeutic product effect decreased 105.57 10.37 153 173376 125502 53050035
Hand deformity 104.70 10.37 74 173455 84775 53090762
Injection site erythema 104.02 10.37 61 173468 77188 53098349
Malaise 103.80 10.37 709 172820 356908 52818629
Derealisation 103.64 10.37 55 173474 948 53174589
Erythema 103.09 10.37 223 173306 156746 53018791
Neuropathy peripheral 101.96 10.37 111 173418 103076 53072461
Hypokinesia 101.72 10.37 165 173364 12862 53162675
Suspected suicide 101.64 10.37 96 173433 4272 53171265
Drug withdrawal syndrome 100.63 10.37 257 173272 27765 53147772
Treatment noncompliance 100.54 10.37 285 173244 32750 53142787
Liver injury 100.26 10.37 222 173307 21881 53153656
Bipolar I disorder 99.44 10.37 65 173464 1672 53173865
Gastrointestinal disorder 97.90 10.37 89 173440 89915 53085622
Persecutory delusion 97.00 10.37 76 173453 2616 53172921
Obsessive-compulsive disorder 97.00 10.37 86 173443 3524 53172013
Pemphigus 96.21 10.37 118 173411 103913 53071624
Pneumonia aspiration 95.82 10.37 287 173242 34014 53141523
Mucosal inflammation 95.39 10.37 13 173516 42771 53132766
Hallucination, visual 94.44 10.37 197 173332 18635 53156902
Arthritis 94.15 10.37 87 173442 87211 53088326
Somnambulism 93.23 10.37 101 173428 5301 53170236
Disorganised speech 92.69 10.37 52 173477 1005 53174532
Plasma cell myeloma 90.72 10.37 22 173507 47852 53127685
Mood swings 90.13 10.37 185 173344 17301 53158236
Torsade de pointes 89.92 10.37 156 173373 12849 53162688
Feeling of despair 89.83 10.37 65 173464 1980 53173557
Sleep-related eating disorder 89.39 10.37 46 173483 742 53174795
Mood altered 88.72 10.37 161 173368 13740 53161797
Mental disorder 86.95 10.37 223 173306 24153 53151384
Osteoarthritis 86.27 10.37 62 173467 70424 53105113
Salivary hypersecretion 85.19 10.37 109 173420 6834 53168703
Atrial fibrillation 85.18 10.37 145 173384 111507 53064030
Drug withdrawal syndrome neonatal 84.69 10.37 64 173465 2086 53173451
Pyrexia 84.57 10.37 871 172658 402322 52773215
Urinary tract infection 84.05 10.37 448 173081 239455 52936082
Myoclonus 83.88 10.37 169 173360 15595 53159942
Psychomotor skills impaired 83.05 10.37 65 173464 2234 53173303
Rhabdomyolysis 82.63 10.37 322 173207 43601 53131936
Circulatory collapse 82.27 10.37 209 173320 22505 53153032
Influenza 82.22 10.37 114 173415 95265 53080272
Musculoskeletal pain 82.22 10.37 74 173455 75126 53100411
Cognitive disorder 80.79 10.37 324 173205 44454 53131083
Haemoglobin decreased 79.84 10.37 208 173321 137099 53038438
Injection site pain 79.59 10.37 155 173374 113236 53062301
Foetal exposure during pregnancy 78.37 10.37 270 173259 34445 53141092
Nightmare 77.94 10.37 176 173353 17575 53157962
Long QT syndrome 77.77 10.37 73 173456 3223 53172314
Anti-cyclic citrullinated peptide antibody positive 77.17 10.37 45 173484 57127 53118410
Coma blister 77.02 10.37 26 173503 129 53175408
Impulse-control disorder 76.21 10.37 42 173487 783 53174754
Drug screen positive 75.02 10.37 77 173452 3795 53171742
Hypotonia 74.97 10.37 117 173412 8824 53166713
Dissociation 73.94 10.37 60 173469 2174 53173363
Cellulitis 73.68 10.37 83 173446 75906 53099631
Hyperreflexia 73.57 10.37 90 173439 5390 53170147
Anger 73.42 10.37 139 173390 12251 53163286
Psychiatric symptom 72.49 10.37 85 173444 4868 53170669
Platelet count decreased 72.25 10.37 152 173377 107947 53067590
Bone pain 71.24 10.37 38 173491 50684 53124853
Abdominal pain 70.89 10.37 514 173015 255389 52920148
Panic attack 70.34 10.37 190 173339 21228 53154309
Discomfort 70.09 10.37 127 173402 95345 53080192
Bronchitis 69.35 10.37 164 173365 111735 53063802
Oromandibular dystonia 69.25 10.37 33 173496 447 53175090
Abdominal pain upper 68.45 10.37 293 173236 165998 53009539
Skin ulcer 67.65 10.37 17 173512 36102 53139435
Glossodynia 67.05 10.37 141 173388 100150 53075387
Accidental overdose 67.01 10.37 187 173342 21292 53154245
Suicidal behaviour 66.87 10.37 60 173469 2498 53173039
Electrocardiogram QRS complex shortened 66.47 10.37 32 173497 444 53175093
Psychomotor retardation 66.27 10.37 70 173459 3568 53171969
Flushing 65.35 10.37 80 173449 70520 53105017
Infarction 65.12 10.37 59 173470 2488 53173049
Breast cancer 65.00 10.37 40 173489 49318 53126219
Fluid retention 63.81 10.37 50 173479 54351 53121186
Irritable bowel syndrome 63.80 10.37 31 173498 43601 53131936
Asthenia 63.74 10.37 763 172766 342827 52832710
Generalised tonic-clonic seizure 62.60 10.37 221 173308 28537 53147000
Hypothermia 62.47 10.37 134 173395 12922 53162615
Embolism venous 62.42 10.37 62 173467 2937 53172600
Depressed mood 62.37 10.37 262 173267 36702 53138835
Psoriasis 62.02 10.37 118 173411 86971 53088566
Gastric pH decreased 61.86 10.37 33 173496 575 53174962
Apathy 61.82 10.37 103 173426 8209 53167328
Chest discomfort 60.28 10.37 148 173381 99547 53075990
Injection site pruritus 60.13 10.37 30 173499 41559 53133978
Exposure via ingestion 59.95 10.37 63 173466 3192 53172345
Drooling 59.51 10.37 65 173464 3443 53172094
Folliculitis 59.24 10.37 15 173514 31694 53143843
Hypotonia neonatal 58.63 10.37 39 173490 1034 53174503
Behaviour disorder 58.27 10.37 55 173474 2445 53173092
Insurance issue 58.18 10.37 55 173474 2450 53173087
Tachyphrenia 58.08 10.37 43 173486 1358 53174179
Stupor 57.89 10.37 67 173462 3784 53171753
Muscle injury 57.74 10.37 13 173516 29753 53145784
Urinary hesitation 57.51 10.37 51 173478 2090 53173447
Drug level increased 57.16 10.37 171 173358 20250 53155287
Osteonecrosis of jaw 57.07 10.37 23 173506 36123 53139414
Amenorrhoea 56.79 10.37 106 173423 9243 53166294
Dyspnoea exertional 56.75 10.37 57 173472 54943 53120594
Bone marrow failure 56.74 10.37 14 173515 30101 53145436
Abnormal weight gain 56.71 10.37 45 173484 1578 53173959
Chest pain 56.58 10.37 374 173155 189811 52985726
Gastrointestinal haemorrhage 56.19 10.37 110 173419 80220 53095317
Prescribed overdose 56.00 10.37 133 173396 13726 53161811
C-reactive protein abnormal 55.05 10.37 9 173520 25861 53149676
Schizoaffective disorder 54.82 10.37 50 173479 2127 53173410
Logorrhoea 54.74 10.37 53 173476 2433 53173104
Enuresis 54.15 10.37 50 173479 2161 53173376
Injection site swelling 54.14 10.37 36 173493 42592 53132945
Pleural effusion 53.94 10.37 131 173398 88448 53087089
Interstitial lung disease 53.65 10.37 67 173462 58555 53116982
Posture abnormal 53.57 10.37 51 173478 2292 53173245
Chills 53.47 10.37 169 173360 104679 53070858
Pancreatitis 53.15 10.37 293 173236 45849 53129688
Red blood cell sedimentation rate increased 52.95 10.37 13 173516 28044 53147493
Sleep disorder due to general medical condition, insomnia type 52.88 10.37 8 173521 24341 53151196
Inflammation 52.60 10.37 65 173464 57071 53118466
Pericarditis 52.53 10.37 80 173449 64326 53111211
Psychiatric decompensation 52.45 10.37 40 173489 1322 53174215
Upper respiratory tract infection 52.44 10.37 90 173439 69007 53106530
Bradypnoea 52.33 10.37 59 173470 3238 53172299
Euphoric mood 52.28 10.37 69 173460 4460 53171077
Device expulsion 52.16 10.37 16 173513 29797 53145740
Sympathomimetic effect 51.89 10.37 15 173514 39 53175498
Hypersomnia 51.62 10.37 143 173386 16212 53159325
Conversion disorder 51.48 10.37 44 173485 1715 53173822
Mutism 51.15 10.37 40 173489 1373 53174164
Blood triglycerides increased 50.93 10.37 120 173409 12321 53163216
Prescribed underdose 50.46 10.37 138 173391 15529 53160008
Knee arthroplasty 50.39 10.37 23 173506 33546 53141991
Mobility decreased 50.33 10.37 108 173421 76163 53099374
Decreased appetite 50.21 10.37 452 173077 214522 52961015
Myocardial infarction 50.07 10.37 161 173368 99193 53076344
Diverticulitis 50.01 10.37 27 173502 35774 53139763
Tic 49.76 10.37 39 173490 1343 53174194
Pancytopenia 49.64 10.37 142 173387 90786 53084751
Dementia 49.49 10.37 143 173386 16607 53158930
Drug dependence 49.33 10.37 168 173361 21304 53154233
Myocarditis 48.94 10.37 94 173435 8374 53167163
Major depression 48.62 10.37 88 173441 7494 53168043
Asthma 48.60 10.37 186 173343 108786 53066751
Faecaloma 48.27 10.37 92 173437 8149 53167388
Potentiating drug interaction 47.87 10.37 64 173465 4189 53171348
Gastrooesophageal reflux disease 47.43 10.37 126 173403 82537 53093000
Palmar-plantar erythrodysaesthesia syndrome 47.14 10.37 7 173522 21599 53153938
Osteonecrosis 46.97 10.37 14 173515 26561 53148976
Intestinal pseudo-obstruction 46.96 10.37 30 173499 741 53174796
Urine osmolarity increased 46.48 10.37 17 173512 111 53175426
Schizophreniform disorder 46.45 10.37 15 173514 63 53175474
Basal cell carcinoma 46.03 10.37 10 173519 23459 53152078
Cytomegalovirus infection 45.85 10.37 5 173524 19534 53156003
Affect lability 45.75 10.37 97 173432 9278 53166259
Productive cough 45.75 10.37 71 173458 56658 53118879
Nasal congestion 45.60 10.37 64 173465 53223 53122314
Alcohol abuse 45.44 10.37 44 173485 2020 53173517
Rabbit syndrome 45.27 10.37 22 173507 312 53175225
Myalgia 45.19 10.37 252 173277 133239 53042298
Parkinsonian gait 45.13 10.37 25 173504 471 53175066
Ascites 44.75 10.37 38 173491 39697 53135840
Dyspepsia 44.74 10.37 118 173411 77482 53098055
Blister 44.46 10.37 121 173408 78632 53096905
Acute psychosis 44.25 10.37 47 173482 2411 53173126
Bundle branch block right 44.20 10.37 68 173461 5065 53170472
Vomiting 43.57 10.37 1258 172271 495881 52679656
Alcohol interaction 43.56 10.37 41 173488 1816 53173721
Aspiration 43.45 10.37 100 173429 10110 53165427
Therapeutic product effect incomplete 43.33 10.37 153 173376 91631 53083906
Rheumatoid factor positive 43.30 10.37 42 173487 41156 53134381
Helicobacter infection 43.23 10.37 38 173491 39031 53136506
Epistaxis 43.12 10.37 100 173429 68610 53106927
Duodenal ulcer perforation 42.97 10.37 31 173498 35152 53140385
Anaemia of pregnancy 42.94 10.37 15 173514 84 53175453
Thrombosis 42.73 10.37 83 173446 60710 53114827
Muscle twitching 42.66 10.37 134 173395 16292 53159245
Rhinorrhoea 42.31 10.37 68 173461 53510 53122027
Burning mouth syndrome 42.30 10.37 23 173506 417 53175120
Injection site reaction 42.26 10.37 63 173466 51103 53124434
Homicide 42.20 10.37 22 173507 365 53175172
Polydipsia 42.19 10.37 54 173475 3386 53172151
Dry skin 42.19 10.37 52 173477 45708 53129829
Action tremor 42.05 10.37 21 173508 317 53175220
Hypertension 41.97 10.37 500 173029 224931 52950606
Full blood count decreased 41.85 10.37 13 173516 24016 53151521
Hyperkinesia 41.79 10.37 42 173487 2018 53173519
Jaundice cholestatic 41.72 10.37 69 173460 5465 53170072
Hypersexuality 41.70 10.37 24 173505 488 53175049
Pulmonary arterial hypertension 41.62 10.37 18 173511 27104 53148433
Weight decreased 41.52 10.37 527 173002 234421 52941116
Adjustment disorder with mixed anxiety and depressed mood 41.06 10.37 14 173515 72 53175465
Meconium aspiration syndrome 40.93 10.37 10 173519 9 53175528
Ataxia 40.86 10.37 123 173406 14614 53160923
Tension 40.71 10.37 52 173477 3254 53172283
Negativism 40.70 10.37 22 173507 394 53175143
Fluid overload 40.34 10.37 20 173509 27811 53147726
Impulsive behaviour 40.34 10.37 36 173493 1488 53174049
Granulocytopenia 40.15 10.37 68 173461 5492 53170045
Clonus 40.01 10.37 59 173470 4232 53171305
Neoplasm progression 39.74 10.37 24 173505 29895 53145642
Nephrogenic diabetes insipidus 39.38 10.37 29 173500 908 53174629
Anaphylactic reaction 38.97 10.37 82 173447 58244 53117293
Coronary artery disease 38.87 10.37 31 173498 33406 53142131
Amniotic fluid volume increased 38.86 10.37 16 173513 149 53175388
Thrombocytopenia 38.67 10.37 278 173251 138449 53037088
Bradycardia 38.65 10.37 377 173152 70679 53104858
Myoglobin urine present 38.57 10.37 19 173510 278 53175259
Ventricular fibrillation 38.36 10.37 105 173424 11820 53163717
Contusion 38.04 10.37 208 173321 110524 53065013
Social anxiety disorder 37.75 10.37 21 173508 399 53175138
Alcohol poisoning 37.73 10.37 38 173491 1831 53173706
Injection site bruising 37.72 10.37 40 173489 37606 53137931
Distributive shock 37.66 10.37 28 173501 890 53174647
Clostridium difficile colitis 37.60 10.37 9 173520 19756 53155781
Localised infection 37.53 10.37 20 173509 26696 53148841
Conjunctival abrasion 37.41 10.37 11 173518 31 53175506
Renal failure 37.22 10.37 229 173300 118223 53057314
Metastases to liver 36.78 10.37 12 173517 21484 53154053
Oropharyngeal pain 36.69 10.37 138 173391 81130 53094407
Joint stiffness 36.57 10.37 27 173502 30256 53145281
Slow response to stimuli 36.57 10.37 28 173501 931 53174606
Hyperthermia 36.55 10.37 84 173445 8485 53167052
Self-injurious ideation 36.54 10.37 42 173487 2354 53173183
Right ventricular false tendon 36.38 10.37 9 173520 9 53175528
Tongue biting 36.25 10.37 33 173496 1400 53174137
Postural tremor 36.12 10.37 16 173513 181 53175356
Throat irritation 36.04 10.37 30 173499 31651 53143886
Bursitis 36.02 10.37 14 173515 22478 53153059
Loss of personal independence in daily activities 35.96 10.37 112 173417 69703 53105834
Disinhibition 35.89 10.37 27 173502 874 53174663
H1N1 influenza 35.84 10.37 35 173494 1624 53173913
Leukopenia 35.76 10.37 381 173148 73082 53102455
Menstrual disorder 35.65 10.37 58 173471 4532 53171005
Gastrointestinal sounds abnormal 35.64 10.37 53 173476 3831 53171706
Surgery 35.47 10.37 31 173498 31933 53143604
Medication error 35.46 10.37 221 173308 36144 53139393
Thermal burn 35.17 10.37 62 173467 5171 53170366
Renal papillary necrosis 35.11 10.37 17 173512 239 53175298
Depressive symptom 35.04 10.37 48 173481 3216 53172321
Homicidal ideation 35.01 10.37 36 173493 1778 53173759
Orthostatic hypotension 34.98 10.37 190 173339 29563 53145974
Mental impairment 34.96 10.37 109 173420 13200 53162337
Hyperammonaemia 34.60 10.37 61 173468 5088 53170449
Product substitution issue 34.59 10.37 122 173407 15744 53159793
Metastases to bone 34.49 10.37 10 173519 19318 53156219
Congenital thrombocytopenia 34.49 10.37 11 173518 44 53175493
Congenital hand malformation 34.24 10.37 18 173511 304 53175233
Stereotypy 34.09 10.37 20 173509 422 53175115
Hyperthermia malignant 34.03 10.37 25 173504 780 53174757
Inappropriate affect 34.00 10.37 26 173503 863 53174674
Lung disorder 33.97 10.37 65 173464 47814 53127723
Attention deficit hyperactivity disorder 33.88 10.37 42 173487 2550 53172987
Pain in jaw 33.66 10.37 50 173479 40619 53134918
Oedema peripheral 33.64 10.37 374 173155 170413 53005124
Borderline personality disorder 33.51 10.37 24 173505 719 53174818
Self-medication 33.36 10.37 41 173488 2467 53173070
Hyperphagia 33.27 10.37 34 173495 1667 53173870
Laboratory test abnormal 33.24 10.37 19 173510 24390 53151147
Accidental poisoning 33.16 10.37 23 173506 654 53174883
Viral infection 32.71 10.37 34 173495 32261 53143276
Drug use disorder 32.56 10.37 46 173483 3173 53172364
Apnoea 32.42 10.37 76 173453 7777 53167760
Electrocardiogram repolarisation abnormality 32.35 10.37 30 173499 1304 53174233
Osteoporosis 32.15 10.37 64 173465 46396 53129141
Self esteem decreased 32.03 10.37 21 173508 543 53174994
Drug level above therapeutic 31.84 10.37 51 173478 3933 53171604
Feeling of body temperature change 31.74 10.37 55 173474 4525 53171012
Acute myeloid leukaemia 31.65 10.37 8 173521 16924 53158613
Persistent genital arousal disorder 31.58 10.37 17 173512 302 53175235
Femur fracture 31.48 10.37 50 173479 39535 53136002
Osteomyelitis 31.41 10.37 20 173509 24215 53151322
Feeling guilty 31.31 10.37 20 173509 494 53175043
Product dose omission issue 31.22 10.37 437 173092 191183 52984354
Emotional poverty 30.99 10.37 17 173512 314 53175223
Myelosuppression 30.83 10.37 3 173526 12825 53162712
Colitis 30.73 10.37 55 173474 41497 53134040
Arrhythmia 30.70 10.37 215 173314 36564 53138973
Acute kidney injury 30.55 10.37 612 172917 253256 52922281
Hypertonia 30.40 10.37 55 173474 4682 53170855
Formication 30.13 10.37 50 173479 3971 53171566
Language disorder 29.99 10.37 34 173495 1877 53173660
Blood pressure increased 29.94 10.37 302 173227 140177 53035360
Rectal haemorrhage 29.70 10.37 56 173473 41425 53134112
Metabolic acidosis 29.63 10.37 237 173292 42005 53133532
Hypertonia neonatal 29.42 10.37 15 173514 237 53175300
Psychotic behaviour 29.42 10.37 21 173508 626 53174911
Wound 29.28 10.37 176 173353 91381 53084156
Insomnia 29.17 10.37 806 172723 186266 52989271
Breast cancer metastatic 29.12 10.37 7 173522 15321 53160216
Foot deformity 29.01 10.37 12 173517 18556 53156981
Nephrolithiasis 28.67 10.37 47 173482 36700 53138837
Floppy iris syndrome 28.57 10.37 12 173517 118 53175419
Ventricular tachycardia 28.49 10.37 124 173405 17638 53157899
Renal impairment 28.34 10.37 157 173372 83161 53092376
Torticollis 28.32 10.37 33 173496 1877 53173660
Neoplasm malignant 28.20 10.37 25 173504 25576 53149961
Ammonia increased 27.96 10.37 52 173477 4521 53171016
Peripartum cardiomyopathy 27.96 10.37 13 173516 166 53175371
Blood glucose increased 27.91 10.37 379 173150 76982 53098555
Nuchal rigidity 27.73 10.37 20 173509 606 53174931
Ear infection 27.69 10.37 26 173503 25874 53149663
Decreased interest 27.68 10.37 43 173486 3230 53172307
Joint effusion 27.63 10.37 5 173524 13347 53162190
Antidepressant drug level increased 27.59 10.37 15 173514 272 53175265
Urine sodium increased 27.54 10.37 11 173518 94 53175443
Social avoidant behaviour 27.53 10.37 41 173488 2967 53172570
Hip arthroplasty 27.47 10.37 30 173499 27832 53147705
Cardiac failure 27.46 10.37 165 173364 85679 53089858
Dysphagia 27.45 10.37 406 173123 83991 53091546
Respiratory disorder neonatal 27.45 10.37 24 173505 965 53174572
Neutropenic sepsis 27.23 10.37 7 173522 14642 53160895
Wrong patient received product 27.04 10.37 34 173495 2094 53173443
Blunted affect 26.98 10.37 14 173515 230 53175307
Pyramidal tract syndrome 26.97 10.37 16 173513 345 53175192
Bone disorder 26.90 10.37 17 173512 20666 53154871
Memory impairment 26.89 10.37 406 173123 84351 53091186
Chorea 26.64 10.37 28 173501 1419 53174118
Rash pruritic 26.63 10.37 79 173450 49931 53125606
Pulmonary mass 26.63 10.37 16 173513 19988 53155549
Hyperkalaemia 26.58 10.37 89 173440 54167 53121370
Hypercalcaemia 26.55 10.37 24 173505 24324 53151213
Product quality issue 26.49 10.37 50 173479 36973 53138564
Herbal interaction 26.27 10.37 10 173519 74 53175463
Merycism 26.10 10.37 13 173516 195 53175342
Nodule 26.07 10.37 12 173517 17417 53158120
Amnesia 25.96 10.37 243 173286 45045 53130492
Incoherent 25.95 10.37 51 173478 4621 53170916
Meconium in amniotic fluid 25.94 10.37 14 173515 250 53175287
Small for dates baby 25.93 10.37 45 173484 3707 53171830
Adrenal insufficiency 25.87 10.37 8 173521 14821 53160716
Akinesia 25.86 10.37 32 173497 1939 53173598
Anaphylactic shock 25.82 10.37 20 173509 21873 53153664
Morbid thoughts 25.80 10.37 19 173510 595 53174942
Emotional disorder 25.70 10.37 97 173432 12933 53162604
Myelodysplastic syndrome 25.66 10.37 11 173518 16649 53158888
Personality change due to a general medical condition 25.50 10.37 10 173519 81 53175456
Congenital hearing disorder 25.48 10.37 7 173522 14 53175523
Electrocardiogram abnormal 25.45 10.37 71 173458 8082 53167455
COVID-19 25.37 10.37 51 173478 36837 53138700
Septic shock 25.36 10.37 110 173419 62119 53113418
Neuropsychiatric symptoms 25.34 10.37 19 173510 612 53174925
Mouth ulceration 25.31 10.37 35 173494 29291 53146246
Physical assault 25.28 10.37 23 173506 975 53174562
Oral pain 25.26 10.37 30 173499 26807 53148730
Bladder dilatation 25.20 10.37 21 173508 790 53174747
Colitis ulcerative 25.15 10.37 19 173510 21042 53154495
Status epilepticus 25.12 10.37 107 173422 15077 53160460
Eosinopenia 25.08 10.37 8 173521 32 53175505
Wheezing 25.03 10.37 118 173411 65157 53110380
Cervix neoplasm 24.92 10.37 13 173516 216 53175321
Hypoglycaemia neonatal 24.83 10.37 23 173506 998 53174539
Food craving 24.70 10.37 28 173501 1546 53173991
Limb discomfort 24.59 10.37 28 173501 25494 53150043
Disseminated intravascular coagulation 24.57 10.37 17 173512 19702 53155835
Respiratory tract infection 24.54 10.37 44 173485 33180 53142357
Neck pain 24.51 10.37 106 173423 59910 53115627
Neonatal disorder 24.48 10.37 19 173510 645 53174892
Fungal infection 24.46 10.37 42 173487 32204 53143333
Alcoholism 24.24 10.37 33 173496 2198 53173339
Agranulocytosis 24.20 10.37 146 173383 23603 53151934
Gastritis 24.15 10.37 51 173478 36183 53139354
Neonatal respiratory distress syndrome 24.12 10.37 38 173491 2889 53172648
Injection site rash 23.90 10.37 12 173517 16567 53158970
Urinary incontinence 23.89 10.37 177 173352 30644 53144893
Incontinence 23.75 10.37 83 173446 10660 53164877
Tubulointerstitial nephritis 23.71 10.37 12 173517 16492 53159045
Protein C increased 23.62 10.37 11 173518 141 53175396
Injection site urticaria 23.48 10.37 6 173523 12601 53162936
Sudden death 23.38 10.37 80 173449 10168 53165369
Suppressed lactation 23.35 10.37 16 173513 446 53175091
Bone density decreased 23.20 10.37 4 173525 11060 53164477
Sleep disorder 23.15 10.37 293 173236 58577 53116960
Drug screen false positive 23.05 10.37 21 173508 892 53174645
Immunodeficiency 22.86 10.37 10 173519 14957 53160580
Neurodegenerative disorder 22.84 10.37 14 173515 321 53175216
Electrocardiogram QT interval abnormal 22.82 10.37 11 173518 153 53175384
Abulia 22.80 10.37 15 173514 390 53175147
Bacteraemia 22.80 10.37 11 173518 15538 53159999
Negative thoughts 22.74 10.37 21 173508 908 53174629
Haemorrhoids 22.58 10.37 20 173509 20469 53155068
Depressive delusion 22.54 10.37 6 173523 10 53175527
Device stimulation issue 22.52 10.37 9 173520 77 53175460
Atrioventricular block first degree 22.49 10.37 59 173470 6476 53169061
Malignant melanoma 22.45 10.37 4 173525 10798 53164739
Movement disorder 22.43 10.37 120 173409 18561 53156976
Generalised anxiety disorder 22.36 10.37 30 173499 1970 53173567
Decreased bronchial secretion 22.22 10.37 9 173520 80 53175457
Blood count abnormal 22.18 10.37 20 173509 20295 53155242
Vitamin K decreased 22.18 10.37 6 173523 11 53175526
Cyanosis 22.15 10.37 110 173419 16529 53159008
Seasonal allergy 22.13 10.37 11 173518 15274 53160263
Tenderness 22.06 10.37 19 173510 19711 53155826
Sinus disorder 22.05 10.37 17 173512 18637 53156900
Feelings of worthlessness 22.02 10.37 14 173515 343 53175194
Pulmonary hypertension 21.99 10.37 56 173473 37214 53138323
Pupillary light reflex tests abnormal 21.91 10.37 11 173518 168 53175369
Blepharospasm 21.83 10.37 35 173494 2701 53172836
Sinus congestion 21.76 10.37 10 173519 14528 53161009
Pressure of speech 21.73 10.37 17 173512 584 53174953
Right ventricular failure 21.69 10.37 14 173515 16829 53158708
Disturbance in sexual arousal 21.65 10.37 9 173520 86 53175451
Eye irritation 21.57 10.37 17 173512 18432 53157105
Tonic clonic movements 21.57 10.37 24 173505 1298 53174239
Crying 21.52 10.37 135 173394 22127 53153410
Parasomnia 21.46 10.37 15 173514 432 53175105
Tongue spasm 21.40 10.37 8 173521 56 53175481
Burning sensation 21.36 10.37 82 173447 47931 53127606
Flatulence 21.31 10.37 44 173485 31473 53144064
Spasmodic dysphonia 21.30 10.37 9 173520 90 53175447
Schizoaffective disorder bipolar type 21.28 10.37 10 173519 131 53175406
Eye movement disorder 21.28 10.37 49 173480 4956 53170581
Bipolar II disorder 21.21 10.37 13 173516 298 53175239
Diverticulum 21.19 10.37 6 173523 11773 53163764
No adverse event 20.92 10.37 62 173467 39203 53136334
Dependence 20.78 10.37 30 173499 2111 53173426
Post-traumatic stress disorder 20.69 10.37 47 173482 4711 53170826
Slow speech 20.66 10.37 24 173505 1361 53174176
Increased appetite 20.62 10.37 71 173458 9051 53166486
Type 1 diabetes mellitus 20.59 10.37 38 173491 3285 53172252
Hostility 20.56 10.37 26 173503 1611 53173926
Epilepsy 20.55 10.37 149 173380 25618 53149919
Ulcer 20.55 10.37 22 173507 20597 53154940
Electrocardiogram T wave inversion 20.55 10.37 40 173489 3599 53171938
Gastric disorder 20.49 10.37 42 173487 30123 53145414
Personality disorder 20.46 10.37 43 173486 4088 53171449
Central obesity 20.42 10.37 21 173508 1037 53174500
Teratoma benign 20.38 10.37 8 173521 65 53175472
Lacrimation increased 20.31 10.37 17 173512 17886 53157651
Melaena 20.26 10.37 40 173489 29089 53146448
Sense of a foreshortened future 20.21 10.37 5 173524 5 53175532
Aphasia 20.14 10.37 170 173359 30608 53144929
Breast engorgement 20.08 10.37 9 173520 105 53175432
Psychotic symptom 20.02 10.37 21 173508 1062 53174475
Cerebellar atrophy 20.01 10.37 17 173512 657 53174880
Hyporesponsive to stimuli 20.00 10.37 21 173508 1063 53174474
Cytopenia 19.94 10.37 3 173526 9167 53166370
Dehydration 19.94 10.37 407 173122 168003 53007534
Vestibular migraine 19.92 10.37 11 173518 206 53175331
Fear of weight gain 19.89 10.37 6 173523 19 53175518
Somatic symptom disorder of pregnancy 19.85 10.37 9 173520 108 53175429
Haemophagocytic lymphohistiocytosis 19.84 10.37 3 173526 9134 53166403
Resting tremor 19.83 10.37 18 173511 761 53174776
Clostridium difficile infection 19.67 10.37 38 173491 27855 53147682
Mental status changes 19.61 10.37 206 173323 39365 53136172
Bruxism 19.60 10.37 37 173492 3254 53172283
Starvation ketoacidosis 19.57 10.37 8 173521 73 53175464
Hyperhidrosis 19.55 10.37 432 173097 96361 53079176
Postmortem blood drug level abnormal 19.50 10.37 12 173517 277 53175260
Infective pulmonary exacerbation of cystic fibrosis 19.49 10.37 6 173523 11150 53164387
Idiopathic intracranial hypertension 19.47 10.37 33 173496 2667 53172870
Binge eating 19.45 10.37 14 173515 423 53175114
Hospitalisation 19.44 10.37 143 173386 70869 53104668
Bradycardia neonatal 19.39 10.37 19 173510 885 53174652
Antisocial behaviour 19.35 10.37 12 173517 281 53175256
Lung neoplasm malignant 19.35 10.37 16 173513 16936 53158601
Delusional perception 19.27 10.37 11 173518 220 53175317
Procedural pain 19.27 10.37 12 173517 14705 53160832
Tuberculosis 19.26 10.37 6 173523 11065 53164472
Injection site warmth 19.23 10.37 11 173518 14117 53161420
Patient uncooperative 19.23 10.37 10 173519 165 53175372
Psychogenic tremor 19.22 10.37 6 173523 22 53175515
Ventricular arrhythmia 19.19 10.37 39 173490 3621 53171916
Pallor 19.17 10.37 144 173385 25038 53150499
Device difficult to use 19.16 10.37 5 173524 10354 53165183
False positive investigation result 19.13 10.37 16 173513 605 53174932
Diabetes insipidus 19.12 10.37 32 173497 2559 53172978
Haemoptysis 19.08 10.37 39 173490 28000 53147537
Affective disorder 19.06 10.37 50 173479 5489 53170048
Anterior displaced anus 19.01 10.37 6 173523 23 53175514
Pulmonary embolism 18.94 10.37 497 173032 113945 53061592
Head titubation 18.94 10.37 17 173512 708 53174829
Radial nerve palsy 18.94 10.37 14 173515 441 53175096
Child abuse 18.93 10.37 4 173525 0 53175537
Gastroenteritis viral 18.88 10.37 21 173508 19324 53156213
Apraxia 18.87 10.37 26 173503 1752 53173785
Musculoskeletal discomfort 18.86 10.37 14 173515 15646 53159891
Aortic bruit 18.81 10.37 6 173523 24 53175513
Resuscitation 18.76 10.37 21 173508 1143 53174394
Antipsychotic drug level below therapeutic 18.76 10.37 12 173517 297 53175240
Ear pain 18.76 10.37 43 173486 29630 53145907
Peritonitis bacterial 18.74 10.37 4 173525 9501 53166036
Compartment syndrome 18.73 10.37 28 173501 2033 53173504
Obsessive-compulsive symptom 18.72 10.37 7 173522 49 53175488
Inappropriate antidiuretic hormone secretion 18.61 10.37 97 173432 14854 53160683
Ileus 18.60 10.37 97 173432 14858 53160679
Muscle disorder 18.55 10.37 44 173485 4537 53171000
Pneumonitis 18.54 10.37 46 173483 30842 53144695
Convulsive threshold lowered 18.52 10.37 13 173516 377 53175160
Cerebrovascular accident 18.51 10.37 236 173293 104938 53070599
Skin exfoliation 18.50 10.37 58 173471 36025 53139512
Food interaction 18.43 10.37 16 173513 637 53174900
Selective eating disorder 18.37 10.37 27 173502 1931 53173606
Nystagmus 18.29 10.37 52 173477 5984 53169553
Chronic obstructive pulmonary disease 18.18 10.37 120 173409 60953 53114584
Transfusion 18.15 10.37 11 173518 13676 53161861
Distal intestinal obstruction syndrome 18.12 10.37 14 173515 472 53175065
Ballismus 18.10 10.37 8 173521 90 53175447
Rash maculo-papular 18.10 10.37 44 173485 29705 53145832
Chronic kidney disease 18.07 10.37 76 173453 43294 53132243
Dementia with Lewy bodies 18.04 10.37 12 173517 318 53175219
Muscular weakness 18.01 10.37 226 173303 100766 53074771
Upper-airway cough syndrome 17.95 10.37 4 173525 9223 53166314
Acidosis 17.87 10.37 79 173450 11313 53164224
Osteopenia 17.84 10.37 20 173509 18335 53157202
Compulsive sexual behaviour 17.82 10.37 7 173522 57 53175480
Pupil fixed 17.78 10.37 25 173504 1717 53173820
Blood calcium decreased 17.71 10.37 23 173506 19771 53155766
Neonatal hypotension 17.67 10.37 9 173520 142 53175395
Reduced facial expression 17.64 10.37 25 173504 1729 53173808
Diabetic ketoacidosis 17.55 10.37 118 173411 19797 53155740
Unevaluable event 17.53 10.37 92 173437 49406 53126131
Tongue movement disturbance 17.50 10.37 11 173518 264 53175273
Aplastic anaemia 17.47 10.37 3 173526 8318 53167219
Ventricular extrasystoles 17.41 10.37 80 173449 11644 53163893
Pulmonary artery stenosis congenital 17.39 10.37 11 173518 267 53175270
Candida infection 17.33 10.37 35 173494 25238 53150299
Somatic delusion 17.29 10.37 15 173514 597 53174940
Stoma site discharge 17.28 10.37 29 173500 2325 53173212
Screaming 17.27 10.37 35 173494 3242 53172295
Uveitis 17.19 10.37 5 173524 9639 53165898
Skin reaction 17.14 10.37 9 173520 12114 53163423
Tendonitis 17.11 10.37 18 173511 16988 53158549
Musculoskeletal disorder 17.08 10.37 19 173510 17480 53158057
Angina pectoris 17.07 10.37 43 173486 28682 53146855
Parosmia 17.06 10.37 43 173486 4607 53170930
Perinatal depression 16.99 10.37 15 173514 611 53174926
Device related infection 16.99 10.37 30 173499 22756 53152781
Poverty of speech 16.89 10.37 12 173517 355 53175182
Megacolon 16.86 10.37 26 173503 1940 53173597
Dermatitis 16.84 10.37 15 173514 15311 53160226
Product storage error 16.79 10.37 11 173518 13119 53162418
Angioedema 16.76 10.37 75 173454 42001 53133536
Somatic hallucination 16.70 10.37 4 173525 3 53175534
Cardiotoxicity 16.67 10.37 57 173472 7242 53168295
Lymphocyte count decreased 16.67 10.37 42 173487 28010 53147527
Migraine 16.66 10.37 174 173355 80243 53095294
Hypoacusis 16.63 10.37 30 173499 22569 53152968
Haematochezia 16.58 10.37 76 173453 42282 53133255
Dysphonia 16.56 10.37 75 173454 41863 53133674
Post procedural haemorrhage 16.45 10.37 3 173526 7965 53167572
Indifference 16.43 10.37 8 173521 114 53175423
Faeces discoloured 16.40 10.37 20 173509 17666 53157871
Gait deviation 16.39 10.37 7 173522 72 53175465
Gastroenteritis 16.29 10.37 37 173492 25579 53149958
Cystitis 16.27 10.37 88 173441 46900 53128637
Haematotoxicity 16.25 10.37 3 173526 7894 53167643
Dysgeusia 16.23 10.37 78 173451 42853 53132684
Paralysis 16.20 10.37 67 173462 9317 53166220
Hallucination, olfactory 16.17 10.37 10 173519 233 53175304
Hypoaesthesia 16.16 10.37 320 173209 132675 53042862
Antidepressant drug level above therapeutic 16.15 10.37 12 173517 381 53175156
Neurological decompensation 16.07 10.37 29 173500 2463 53173074
Pneumothorax 16.07 10.37 16 173513 15491 53160046
Bradycardia foetal 16.04 10.37 12 173517 385 53175152
Atelectasis 16.00 10.37 25 173504 19901 53155636
Sudden cardiac death 15.97 10.37 27 173502 2177 53173360
Abdominal pain lower 15.90 10.37 33 173496 23560 53151977
Hypocalcaemia 15.87 10.37 46 173483 29291 53146246
Dyslipidaemia 15.87 10.37 51 173478 6276 53169261
Constipation 15.84 10.37 508 173021 197904 52977633
Eye haemorrhage 15.78 10.37 3 173526 7731 53167806
Panic disorder 15.73 10.37 30 173499 2658 53172879
Haematuria 15.73 10.37 44 173485 28345 53147192
Swelling face 15.70 10.37 115 173414 57053 53118484
Muscle spasticity 15.68 10.37 21 173508 17817 53157720
Cortisol increased 15.67 10.37 12 173517 399 53175138
Haematoma 15.58 10.37 57 173472 33787 53141750
Spinal stenosis 15.57 10.37 14 173515 14227 53161310
Metastases to central nervous system 15.56 10.37 10 173519 12047 53163490
Ageusia 15.55 10.37 11 173518 12603 53162934
Lactation disorder 15.55 10.37 11 173518 323 53175214
Brain oedema 15.54 10.37 86 173443 13472 53162065
Neonatal hypoxia 15.54 10.37 13 173516 492 53175045
Antipsychotic drug level above therapeutic 15.53 10.37 18 173511 1018 53174519
Floppy infant 15.51 10.37 7 173522 83 53175454
Induced abortion failed 15.48 10.37 10 173519 252 53175285
Intentional product use issue 15.37 10.37 156 173373 72338 53103199
Malignant polyp 15.34 10.37 9 173520 190 53175347
Deafness 15.33 10.37 20 173509 17156 53158381
Eczema 15.32 10.37 35 173494 24147 53151390
Pseudobulbar palsy 15.28 10.37 4 173525 6 53175531
C-reactive protein increased 15.27 10.37 144 173385 67742 53107795
Mitral valve incompetence 15.26 10.37 25 173504 19526 53156011
Ileus paralytic 15.23 10.37 41 173488 4570 53170967
Large for dates baby 15.23 10.37 13 173516 506 53175031
Proteinuria 15.16 10.37 22 173507 18046 53157491
Apparent life threatening event 15.15 10.37 7 173522 88 53175449
Pulseless electrical activity 15.13 10.37 56 173473 7398 53168139
Bone marrow eosinophilic leukocyte count increased 15.12 10.37 5 173524 23 53175514
Agitation neonatal 15.10 10.37 13 173516 512 53175025
Echolalia 15.05 10.37 9 173520 197 53175340
Amimia 15.05 10.37 6 173523 51 53175486
Retrograde amnesia 15.05 10.37 12 173517 424 53175113
Gout 15.04 10.37 11 173518 12388 53163149
Wrong patient 15.01 10.37 7 173522 90 53175447
Sleep disorder due to a general medical condition 14.99 10.37 3 173526 7454 53168083
Metastases to lymph nodes 14.94 10.37 3 173526 7437 53168100
Cytokine release syndrome 14.89 10.37 4 173525 8125 53167412
Thrombotic thrombocytopenic purpura 14.84 10.37 37 173492 3937 53171600
Drowning 14.83 10.37 12 173517 433 53175104
Post procedural infection 14.76 10.37 4 173525 8077 53167460
Tricuspid valve incompetence 14.75 10.37 15 173514 14381 53161156
Skin necrosis 14.72 10.37 8 173521 10564 53164973
Depression suicidal 14.72 10.37 22 173507 1597 53173940
Night sweats 14.71 10.37 61 173468 34886 53140651
Soliloquy 14.69 10.37 9 173520 206 53175331
Fall 14.67 10.37 1355 172174 357085 52818452
Acute myocardial infarction 14.63 10.37 57 173472 33178 53142359
Dissociative amnesia 14.62 10.37 5 173524 26 53175511
Skull fracture 14.58 10.37 17 173512 968 53174569
Lymphoma 14.50 10.37 8 173521 10474 53165063
Hiatus hernia 14.48 10.37 26 173503 19594 53155943
Central nervous system injury 14.48 10.37 8 173521 150 53175387
Suspiciousness 14.44 10.37 11 173518 363 53175174
Mass 14.41 10.37 12 173517 12657 53162880
Progressive multifocal leukoencephalopathy 14.41 10.37 11 173518 12118 53163419
White blood cell count decreased 14.38 10.37 302 173227 124173 53051364
Pre-eclampsia 14.35 10.37 61 173468 8586 53166951
Pyroglutamic acidosis 14.33 10.37 11 173518 367 53175170
Pulmonary oedema 14.31 10.37 109 173420 53614 53121923
Hyperinsulinaemia 14.30 10.37 7 173522 101 53175436
Asphyxia 14.29 10.37 47 173482 5854 53169683
Nail disorder 14.28 10.37 7 173522 9798 53165739
Post procedural complication 14.27 10.37 20 173509 16646 53158891
Complication associated with device 14.24 10.37 19 173510 16146 53159391
Psychotic disorder due to a general medical condition 14.24 10.37 9 173520 218 53175319
Diabetic cardiomyopathy 14.20 10.37 3 173526 0 53175537
Erotomanic delusion 14.20 10.37 3 173526 0 53175537
Micrographia 14.20 10.37 3 173526 0 53175537
Buccoglossal syndrome 14.20 10.37 3 173526 0 53175537
Hypothermia neonatal 14.20 10.37 3 173526 0 53175537
Patella fracture 14.17 10.37 24 173505 1938 53173599
Allergic hepatitis 14.17 10.37 5 173524 29 53175508
Toxic encephalopathy 14.17 10.37 47 173482 5880 53169657
Stoma site hypergranulation 14.13 10.37 13 173516 559 53174978
Bronchospasm 14.13 10.37 20 173509 16578 53158959
Therapy interrupted 14.12 10.37 26 173503 19410 53156127
Electroconvulsive therapy 14.11 10.37 6 173523 61 53175476
Grandiosity 14.10 10.37 9 173520 222 53175315
Syncope 14.07 10.37 470 173059 111523 53064014
Encopresis 14.05 10.37 7 173522 105 53175432
Ejection fraction decreased 14.03 10.37 27 173502 19821 53155716
Pneumonia viral 14.01 10.37 3 173526 7109 53168428
Acute generalised exanthematous pustulosis 14 10.37 8 173521 10273 53165264
Spinal fracture 13.90 10.37 20 173509 16465 53159072
Genital labial adhesions 13.89 10.37 5 173524 31 53175506
Bundle branch block 13.89 10.37 16 173513 899 53174638
Gastric ulcer 13.87 10.37 35 173494 23334 53152203
Hot flush 13.87 10.37 93 173436 47067 53128470
Electrocardiogram ST segment elevation 13.86 10.37 35 173494 3754 53171783
Lack of spontaneous speech 13.84 10.37 8 173521 164 53175373
Neurological examination abnormal 13.68 10.37 9 173520 234 53175303
Pulmonary fibrosis 13.68 10.37 37 173492 24098 53151439
Tearfulness 13.67 10.37 37 173492 4137 53171400
Bladder prolapse 13.66 10.37 24 173505 1996 53173541
Defect conduction intraventricular 13.65 10.37 7 173522 112 53175425
Breast discharge 13.65 10.37 16 173513 916 53174621
Confabulation 13.61 10.37 10 173519 312 53175225
Therapeutic response changed 13.61 10.37 16 173513 919 53174618
Anal sphincter atony 13.55 10.37 9 173520 238 53175299
Pulse absent 13.51 10.37 43 173486 5263 53170274
Therapeutic product ineffective 13.49 10.37 18 173511 1176 53174361
Breast enlargement 13.46 10.37 21 173508 1583 53173954
Labelled drug-food interaction issue 13.42 10.37 4 173525 12 53175525
Tongue paralysis 13.42 10.37 9 173520 242 53175295
Dysphoria 13.31 10.37 43 173486 5306 53170231
Oesophageal food impaction 13.22 10.37 8 173521 179 53175358
Spinal compression fracture 13.21 10.37 15 173514 13675 53161862
Congestive cardiomyopathy 13.21 10.37 47 173482 6091 53169446
Diabetic complication 13.19 10.37 16 173513 950 53174587
Hygroma colli 13.18 10.37 4 173525 13 53175524
Leukopenia neonatal 13.14 10.37 5 173524 37 53175500
Red blood cell count decreased 13.13 10.37 66 173463 35837 53139700
Impaired self-care 13.10 10.37 23 173506 1912 53173625
Dropped head syndrome 13.07 10.37 7 173522 123 53175414
Duplicate therapy error 13.02 10.37 6 173523 75 53175462
Dysmetropsia 13.02 10.37 6 173523 75 53175462
Limbic encephalitis 12.97 10.37 9 173520 256 53175281
Agitated depression 12.87 10.37 7 173522 127 53175410
Respiratory disorder 12.86 10.37 62 173467 34035 53141502
Libido increased 12.82 10.37 17 173512 1104 53174433
Bronchial aspiration procedure 12.80 10.37 8 173521 190 53175347
Brain hypoxia 12.80 10.37 12 173517 529 53175008
Exostosis 12.77 10.37 11 173518 11413 53164124
Cellulitis orbital 12.76 10.37 11 173518 434 53175103
Flight of ideas 12.74 10.37 10 173519 345 53175192
Drug diversion 12.72 10.37 15 173514 864 53174673
Tooth abscess 12.71 10.37 15 173514 13443 53162094
Neonatal behavioural syndrome 12.70 10.37 5 173524 41 53175496
Abnormal dreams 12.66 10.37 68 173461 10533 53165004
Electroencephalogram abnormal 12.65 10.37 34 173495 3787 53171750
Diffuse large B-cell lymphoma 12.64 10.37 3 173526 6622 53168915
Foetal death 12.59 10.37 62 173467 9285 53166252
Oscillopsia 12.58 10.37 7 173522 133 53175404
Amphetamines positive 12.58 10.37 7 173522 133 53175404
Autonomic nervous system imbalance 12.56 10.37 27 173502 2607 53172930
Periorbital swelling 12.53 10.37 21 173508 1682 53173855
Multiple fractures 12.51 10.37 3 173526 6578 53168959
Infusion site pain 12.51 10.37 12 173517 11821 53163716
Reflexes abnormal 12.49 10.37 13 173516 651 53174886
Insulin resistance 12.49 10.37 14 173515 763 53174774
Female sexual dysfunction 12.49 10.37 5 173524 43 53175494
Colitis ischaemic 12.48 10.37 69 173460 10805 53164732
Kussmaul respiration 12.44 10.37 8 173521 200 53175337
Electrocardiogram change 12.41 10.37 13 173516 656 53174881
Anhedonia 12.39 10.37 68 173461 10619 53164918
Rectal prolapse 12.36 10.37 22 173507 1849 53173688
Burnout syndrome 12.30 10.37 8 173521 204 53175333
Sleep talking 12.29 10.37 16 173513 1020 53174517
Pathological fracture 12.29 10.37 6 173523 8418 53167119
Blood iron decreased 12.24 10.37 13 173516 12215 53163322
Respiratory tract congestion 12.23 10.37 18 173511 14681 53160856
Intervertebral disc protrusion 12.17 10.37 34 173495 21911 53153626
Ideas of reference 12.17 10.37 6 173523 88 53175449
Exaggerated startle response 12.13 10.37 3 173526 3 53175534
Congenital emphysema 12.13 10.37 3 173526 3 53175534
Hypernatraemia 12.11 10.37 50 173479 6947 53168590
Asterixis 12.05 10.37 18 173511 1306 53174231
Acinetobacter bacteraemia 12.05 10.37 6 173523 90 53175447
Cardiopulmonary failure 12.04 10.37 33 173496 3718 53171819
Hangover 12.02 10.37 19 173510 1449 53174088
Upper limb fracture 11.95 10.37 23 173506 16884 53158653
Swollen tongue 11.92 10.37 154 173375 30926 53144611
Respiratory alkalosis 11.92 10.37 27 173502 2701 53172836
Immune reconstitution inflammatory syndrome 11.86 10.37 3 173526 6343 53169194
Carpal tunnel syndrome 11.85 10.37 25 173504 17742 53157795
Hepatic enzyme increased 11.84 10.37 316 173213 125879 53049658
Blood osmolarity decreased 11.81 10.37 15 173514 933 53174604
Compulsions 11.80 10.37 8 173521 219 53175318
Infantile apnoea 11.76 10.37 15 173514 937 53174600
Labelled drug-drug interaction medication error 11.75 10.37 68 173461 10831 53164706
Dysuria 11.73 10.37 151 173378 30302 53145235
Pseudomonas infection 11.71 10.37 10 173519 10418 53165119
Facial spasm 11.68 10.37 13 173516 703 53174834
Trismus 11.66 10.37 32 173497 3608 53171929
Atrial septal defect 11.65 10.37 49 173480 6865 53168672
Blood pressure systolic increased 11.57 10.37 67 173462 35110 53140427
Tooth infection 11.55 10.37 18 173511 14345 53161192
Encephalopathy 11.54 10.37 176 173353 36632 53138905
Postoperative wound infection 11.53 10.37 8 173521 9258 53166279
Splenic injury 11.52 10.37 8 173521 228 53175309
Rebound psychosis 11.51 10.37 4 173525 22 53175515
Withdrawal catatonia 11.49 10.37 5 173524 54 53175483
Kidney duplex 11.49 10.37 5 173524 54 53175483
Sluggishness 11.45 10.37 38 173491 4754 53170783
Ketoacidosis 11.39 10.37 36 173493 4390 53171147
Delusional disorder, unspecified type 11.38 10.37 10 173519 405 53175132
Housebound 11.34 10.37 8 173521 234 53175303
Ovarian germ cell cancer stage II 11.33 10.37 5 173524 56 53175481
Blood folate decreased 11.32 10.37 12 173517 614 53174923
Hyponatraemia 11.25 10.37 446 173083 108161 53067376
Neuralgia 11.23 10.37 39 173490 23482 53152055
Product use issue 11.22 10.37 357 173172 139227 53036310
Angle closure glaucoma 11.17 10.37 24 173505 2316 53173221
Tremor neonatal 11.17 10.37 6 173523 106 53175431
Hypoglycaemia 11.16 10.37 261 173268 58752 53116785
Metabolic alkalosis 11.16 10.37 28 173501 2991 53172546
Tachypnoea 11.14 10.37 89 173440 15765 53159772
Hypothyroidism 11.08 10.37 172 173357 35935 53139602
Lactate pyruvate ratio increased 11.07 10.37 6 173523 108 53175429
Poriomania 11.07 10.37 6 173523 108 53175429
Fibromyalgia 11.01 10.37 91 173438 43984 53131553
Parkinsonian rest tremor 10.98 10.37 6 173523 110 53175427
Libido decreased 10.95 10.37 26 173503 2683 53172854
Protrusion tongue 10.93 10.37 9 173520 333 53175204
Blood creatinine increased 10.93 10.37 196 173333 82466 53093071
Blood sodium increased 10.93 10.37 26 173503 2686 53172851
Macroprolactinaemia 10.92 10.37 3 173526 6 53175531
Atrophy of globe 10.92 10.37 3 173526 6 53175531
Wound healing normal 10.92 10.37 3 173526 6 53175531
Groin pain 10.91 10.37 9 173520 9539 53165998
Obsessive thoughts 10.89 10.37 11 173518 532 53175005
Alcohol use 10.87 10.37 22 173507 2036 53173501
Lethargy 10.87 10.37 240 173289 53520 53122017
Staphylococcal infection 10.85 10.37 77 173452 38471 53137066
Immunosuppression 10.83 10.37 6 173523 7838 53167699
Cholecystitis acute 10.83 10.37 6 173523 7837 53167700
Foetal chromosome abnormality 10.82 10.37 4 173525 27 53175510
Blood pressure systolic decreased 10.79 10.37 43 173486 5881 53169656
Somnolence neonatal 10.79 10.37 6 173523 114 53175423
Escherichia infection 10.78 10.37 14 173515 12036 53163501
Arthritis infective 10.78 10.37 3 173526 5952 53169585
Chronic sinusitis 10.75 10.37 3 173526 5942 53169595
Eye pruritus 10.72 10.37 17 173512 13452 53162085
Accelerated hypertension 10.72 10.37 10 173519 438 53175099
Suicide threat 10.70 10.37 4 173525 28 53175509
Hepatic cirrhosis 10.69 10.37 27 173502 17995 53157542
Faecal vomiting 10.68 10.37 12 173517 656 53174881
Toxic epidermal necrolysis 10.62 10.37 40 173489 23510 53152027
Ultrasound abdomen abnormal 10.61 10.37 5 173524 66 53175471
Victim of chemical submission 10.58 10.37 8 173521 261 53175276
Peripheral sensory neuropathy 10.57 10.37 5 173524 7143 53168394
Cyst 10.56 10.37 16 173513 12895 53162642
Cardiac death 10.55 10.37 11 173518 552 53174985
Therapy cessation 10.54 10.37 51 173478 27974 53147563
Influenza like illness 10.54 10.37 137 173392 60722 53114815
Acute coronary syndrome 10.53 10.37 11 173518 10413 53165124
Enthesopathy 10.51 10.37 4 173525 6507 53169030
Rotator cuff syndrome 10.51 10.37 15 173514 12390 53163147
Ocular hyperaemia 10.50 10.37 36 173493 21755 53153782
Haemorrhage intracranial 10.49 10.37 17 173512 13335 53162202
Jealous delusion 10.47 10.37 5 173524 68 53175469
Caesarean section 10.46 10.37 94 173435 17226 53158311
Nerve injury 10.46 10.37 8 173521 8807 53166730
Lymphadenopathy 10.41 10.37 72 173457 36183 53139354
Diet refusal 10.41 10.37 12 173517 675 53174862

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1665.43 11.81 1886 119915 90631 32301094
Neuroleptic malignant syndrome 1520.93 11.81 898 120903 16597 32375128
Toxicity to various agents 1395.54 11.81 2433 119368 175608 32216117
Suicide attempt 1202.09 11.81 1057 120744 37187 32354538
Sopor 1002.29 11.81 596 121205 11153 32380572
Drug abuse 854.40 11.81 1263 120538 78980 32312745
Drug interaction 834.86 11.81 2231 119570 215954 32175771
Intentional overdose 817.02 11.81 889 120912 40712 32351013
Overdose 748.16 11.81 1242 120559 85835 32305890
Sedation 667.17 11.81 554 121247 17972 32373753
Psychotic disorder 666.83 11.81 608 121193 22412 32369313
Agitation 624.75 11.81 912 120889 56324 32335401
Depression 610.15 11.81 1209 120592 95851 32295874
Aggression 587.70 11.81 731 121070 38658 32353067
Somnolence 560.94 11.81 1215 120586 102582 32289143
Extrapyramidal disorder 533.94 11.81 405 121396 11490 32380235
Tardive dyskinesia 514.84 11.81 297 121504 5234 32386491
Dystonia 481.91 11.81 364 121437 10259 32381466
Priapism 475.22 11.81 272 121529 4719 32387006
Intentional self-injury 464.03 11.81 398 121403 13502 32378223
Dyskinesia 458.84 11.81 502 121299 23101 32368624
Coma 438.87 11.81 661 121140 41951 32349774
Hallucination 425.34 11.81 731 121070 51888 32339837
Diarrhoea 409.14 11.81 460 121341 364342 32027383
Schizophrenia 408.95 11.81 322 121479 9662 32382063
Delusion 384.90 11.81 349 121452 12759 32378966
Akathisia 378.21 11.81 267 121534 6758 32384967
Depressed level of consciousness 372.29 11.81 599 121202 40248 32351477
Paranoia 323.90 11.81 291 121510 10508 32381217
Dyspnoea 322.67 11.81 539 121262 361506 32030219
Electrocardiogram QT prolonged 316.67 11.81 548 121253 39093 32352632
Mania 311.73 11.81 271 121530 9361 32382364
Suicidal ideation 288.04 11.81 514 121287 37569 32354156
Muscle rigidity 284.51 11.81 275 121526 10911 32380814
Catatonia 284.16 11.81 192 121609 4516 32387209
Diabetes mellitus 277.61 11.81 558 121243 44615 32347110
Restlessness 271.88 11.81 397 121404 24484 32367241
Febrile neutropenia 258.05 11.81 65 121736 119501 32272224
Hallucination, auditory 253.03 11.81 249 121552 10101 32381624
Delirium 247.03 11.81 524 121277 43522 32348203
Parkinsonism 245.81 11.81 217 121584 7652 32384073
Oculogyric crisis 244.06 11.81 116 121685 1341 32390384
Intentional product misuse 233.13 11.81 455 121346 35596 32356129
Abnormal behaviour 222.00 11.81 374 121427 26092 32365633
Pneumonia 214.09 11.81 654 121147 354598 32037127
Nausea 210.61 11.81 567 121234 320282 32071443
Fatigue 209.63 11.81 648 121153 350053 32041672
Serotonin syndrome 207.34 11.81 304 121497 18813 32372912
Bradyphrenia 206.32 11.81 157 121644 4472 32387253
Anaemia 204.19 11.81 327 121474 223297 32168428
Blood creatine phosphokinase increased 201.65 11.81 493 121308 44983 32346742
Arthralgia 198.68 11.81 159 121642 148289 32243436
Rash 196.90 11.81 300 121501 209033 32182692
Confusional state 195.71 11.81 1054 120747 142061 32249664
Obsessive-compulsive disorder 195.31 11.81 156 121645 4778 32386947
Poisoning deliberate 181.76 11.81 167 121634 6208 32385517
Malignant neoplasm progression 172.54 11.81 41 121760 78455 32313270
Blood prolactin abnormal 171.67 11.81 78 121723 807 32390918
Psychomotor hyperactivity 169.94 11.81 189 121612 8850 32382875
Drug withdrawal syndrome neonatal 167.99 11.81 125 121676 3439 32388286
Weight increased 166.15 11.81 687 121114 82976 32308749
Foetal exposure during pregnancy 162.52 11.81 428 121373 40873 32350852
Bipolar disorder 162.12 11.81 127 121674 3779 32387946
Poisoning 161.30 11.81 204 121597 10954 32380771
Atrial fibrillation 157.35 11.81 124 121677 116580 32275145
Tachycardia 155.12 11.81 647 121154 78441 32313284
Altered state of consciousness 153.71 11.81 287 121514 21710 32370015
Hyperprolactinaemia 153.37 11.81 82 121719 1236 32390489
Euphoric mood 153.07 11.81 139 121662 5088 32386637
Tremor 149.44 11.81 652 121149 80625 32311100
Acute kidney injury 148.96 11.81 581 121220 292887 32098838
Emotional poverty 148.65 11.81 59 121742 422 32391303
Disease progression 146.58 11.81 71 121730 86791 32304934
Cardiac failure congestive 145.26 11.81 68 121733 84784 32306941
Rhabdomyolysis 145.22 11.81 567 121234 66698 32325027
Cough 142.23 11.81 187 121614 138630 32253095
Anxiety 138.56 11.81 718 121083 95287 32296438
Antipsychotic drug level below therapeutic 137.56 11.81 88 121713 1881 32389844
Pyrexia 136.02 11.81 677 121124 319291 32072434
Sexual dysfunction 134.90 11.81 141 121660 6148 32385577
Disinhibition 134.05 11.81 98 121703 2622 32389103
Sepsis 131.35 11.81 247 121554 158587 32233138
Anosognosia 130.62 11.81 63 121738 754 32390971
Plasma cell myeloma 128.77 11.81 29 121772 57585 32334140
Neuropathy peripheral 128.25 11.81 64 121737 76918 32314807
Pain 126.09 11.81 327 121474 187229 32204496
Type 2 diabetes mellitus 122.70 11.81 211 121590 14961 32376764
Restless legs syndrome 122.46 11.81 147 121654 7477 32384248
Pruritus 122.23 11.81 183 121618 128519 32263206
Apathy 122.11 11.81 138 121663 6577 32385148
Hallucination, visual 120.03 11.81 224 121577 16935 32374790
Social avoidant behaviour 119.95 11.81 98 121703 3101 32388624
Asthenia 119.66 11.81 467 121334 235477 32156248
Hyperreflexia 118.94 11.81 95 121706 2909 32388816
Speech disorder 117.79 11.81 286 121515 25967 32365758
Disturbance in social behaviour 117.78 11.81 75 121726 1590 32390135
Hypomania 116.93 11.81 86 121715 2323 32389402
Rheumatoid arthritis 115.83 11.81 15 121786 44529 32347196
Respiratory disorder neonatal 114.55 11.81 67 121734 1212 32390513
Interstitial lung disease 112.93 11.81 51 121750 64950 32326775
Diabetic coma 111.73 11.81 59 121742 866 32390859
Haemoglobin decreased 110.89 11.81 173 121628 119498 32272227
Hyperkalaemia 110.27 11.81 62 121739 69688 32322037
Bradykinesia 110.15 11.81 106 121695 4180 32387545
Joint swelling 109.83 11.81 29 121772 51706 32340019
Irritability 107.86 11.81 266 121535 24388 32367337
Thrombocytopenia 105.51 11.81 251 121550 148048 32243677
Pleural effusion 105.07 11.81 85 121716 78907 32312818
Headache 104.83 11.81 380 121421 195817 32195908
Metabolic syndrome 104.47 11.81 69 121732 1560 32390165
Bezoar 103.47 11.81 56 121745 866 32390859
Decreased appetite 103.03 11.81 287 121514 160526 32231199
Platelet count decreased 101.16 11.81 171 121630 114420 32277305
Back pain 100.56 11.81 163 121638 110890 32280835
Schizoaffective disorder 100.26 11.81 62 121739 1246 32390479
Insomnia 99.35 11.81 680 121121 99668 32292057
Persecutory delusion 99.13 11.81 77 121724 2262 32389463
Pain in extremity 99.03 11.81 184 121617 118717 32273008
Infusion related reaction 97.87 11.81 25 121776 45574 32346151
Cognitive disorder 97.44 11.81 264 121537 25630 32366095
Respiratory arrest 95.35 11.81 281 121520 28627 32363098
Prescribed overdose 94.10 11.81 145 121656 9374 32382351
Psychotic symptom 93.67 11.81 62 121739 1407 32390318
Withdrawal syndrome 93.35 11.81 165 121636 11957 32379768
Oedema peripheral 92.87 11.81 179 121622 113912 32277813
Psychiatric decompensation 92.27 11.81 62 121739 1444 32390281
Pancytopenia 92.25 11.81 124 121677 91111 32300614
Gastrointestinal haemorrhage 92.06 11.81 114 121687 86768 32304957
Sleep disorder 91.07 11.81 263 121538 26489 32365236
Infection 90.98 11.81 110 121691 84605 32307120
Selective eating disorder 88.86 11.81 64 121737 1672 32390053
Therapeutic product effect variable 88.83 11.81 69 121732 2027 32389698
Blood prolactin increased 88.69 11.81 62 121739 1543 32390182
Dysarthria 88.64 11.81 300 121501 32901 32358824
Drug hypersensitivity 88.00 11.81 87 121714 73313 32318412
Loss of personal independence in daily activities 87.71 11.81 260 121541 26573 32365152
Hypertonia neonatal 86.82 11.81 38 121763 357 32391368
Miosis 86.62 11.81 133 121668 8571 32383154
Suicidal behaviour 86.40 11.81 59 121742 1412 32390313
Urticaria 85.90 11.81 59 121742 59555 32332170
Stomatitis 84.54 11.81 23 121778 40206 32351519
Myocardial infarction 84.45 11.81 219 121582 125457 32266268
Increased appetite 83.61 11.81 112 121689 6364 32385361
Obesity 82.84 11.81 142 121659 10040 32381685
Anger 82.75 11.81 155 121646 11749 32379976
Salivary hypersecretion 82.49 11.81 125 121676 7963 32383762
Mydriasis 80.97 11.81 110 121691 6336 32385389
Drug withdrawal syndrome 79.89 11.81 210 121591 20021 32371704
Metabolic disorder 78.36 11.81 85 121716 3868 32387857
Bruxism 77.52 11.81 58 121743 1609 32390116
Cogwheel rigidity 76.59 11.81 53 121748 1297 32390428
Coronary artery disease 75.97 11.81 46 121755 49660 32342065
Epistaxis 75.64 11.81 59 121742 55796 32335929
Mental disorder 74.56 11.81 167 121634 14381 32377344
Psychomotor retardation 73.90 11.81 72 121729 2883 32388842
Drug screen positive 73.46 11.81 85 121716 4156 32387569
Sedation complication 73.23 11.81 49 121752 1133 32390592
Seizure 72.95 11.81 650 121151 103204 32288521
Ascites 72.23 11.81 30 121771 40161 32351564
Mental impairment 71.64 11.81 132 121669 9880 32381845
Stupor 70.95 11.81 71 121730 2938 32388787
Cardiac failure 70.16 11.81 149 121652 91524 32300201
Acute myocardial infarction 70.06 11.81 62 121739 55087 32336638
Neonatal behavioural syndrome 69.67 11.81 24 121777 108 32391617
Renal failure 69.42 11.81 264 121537 134214 32257511
Nasopharyngitis 69.35 11.81 82 121719 63705 32328020
Dementia 68.98 11.81 154 121647 13232 32378493
Dysphoria 68.73 11.81 62 121739 2249 32389476
Loss of consciousness 67.83 11.81 536 121265 82171 32309554
Pneumonitis 67.65 11.81 15 121786 30119 32361606
Cytomegalovirus infection 67.60 11.81 8 121793 25456 32366269
Visceral congestion 66.68 11.81 35 121766 507 32391218
Agitation neonatal 66.63 11.81 45 121756 1057 32390668
Homicidal ideation 66.46 11.81 65 121736 2615 32389110
Hyperthermia 66.39 11.81 133 121668 10595 32381130
Disorientation 65.09 11.81 273 121528 33152 32358573
Neonatal respiratory distress syndrome 65.03 11.81 79 121722 4068 32387657
Abdominal pain 64.08 11.81 315 121486 149214 32242511
Anaphylactic reaction 63.86 11.81 17 121784 30155 32361570
Herpes zoster 63.39 11.81 21 121780 32320 32359405
Mucosal inflammation 63.31 11.81 23 121778 33411 32358314
Sinusitis 62.99 11.81 29 121772 36531 32355194
Drug dependence 62.50 11.81 212 121589 23272 32368453
Hypertriglyceridaemia 62.44 11.81 115 121686 8604 32383121
Pneumonia aspiration 62.21 11.81 312 121489 40844 32350881
Akinesia 61.85 11.81 62 121739 2571 32389154
Prescription drug used without a prescription 61.70 11.81 46 121755 1269 32390456
Renal impairment 60.43 11.81 162 121639 91810 32299915
Posture abnormal 59.71 11.81 56 121745 2137 32389588
Thrombosis 58.64 11.81 51 121750 45703 32346022
Treatment noncompliance 58.39 11.81 229 121572 26973 32364752
Influenza 58.12 11.81 52 121749 45962 32345763
Suspected suicide 58.09 11.81 64 121737 2964 32388761
Asthma 57.84 11.81 48 121753 44017 32347708
Sinus tachycardia 57.44 11.81 163 121638 16251 32375474
Antipsychotic drug level above therapeutic 57.44 11.81 42 121759 1124 32390601
Dyspnoea exertional 56.87 11.81 38 121763 38923 32352802
Depressed mood 56.67 11.81 174 121627 18126 32373599
Logorrhoea 56.05 11.81 57 121744 2405 32389320
Myocarditis 56.02 11.81 130 121671 11460 32380265
Chills 55.59 11.81 132 121669 77952 32313773
Pneumocystis jirovecii pneumonia 55.22 11.81 4 121797 18866 32372859
Chronic obstructive pulmonary disease 54.80 11.81 61 121740 48692 32343033
Malaise 54.52 11.81 414 121387 176724 32215001
Blood triglycerides increased 53.94 11.81 148 121653 14471 32377254
Colitis 53.89 11.81 30 121771 33921 32357804
Coma scale abnormal 53.50 11.81 67 121734 3560 32388165
Poor quality sleep 53.48 11.81 103 121698 7971 32383754
Unresponsive to stimuli 53.36 11.81 225 121576 27384 32364341
Cardio-respiratory arrest 53.33 11.81 376 121425 55613 32336112
Vomiting 53.27 11.81 595 121206 234962 32156763
Tearfulness 53.18 11.81 47 121754 1659 32390066
Torticollis 53.11 11.81 40 121761 1121 32390604
Depression suicidal 52.67 11.81 43 121758 1359 32390366
Disturbance in attention 52.64 11.81 202 121599 23551 32368174
Psoriasis 52.63 11.81 57 121744 46066 32345659
Brugada syndrome 52.13 11.81 33 121768 692 32391033
Cellulitis 51.02 11.81 68 121733 50162 32341563
Osteonecrosis of jaw 50.92 11.81 6 121795 19160 32372565
Hypokinesia 50.58 11.81 103 121698 8302 32383423
Small for dates baby 50.56 11.81 63 121738 3330 32388395
Hyperkinesia 50.44 11.81 52 121749 2230 32389495
Medication error 50.23 11.81 192 121609 22343 32369382
Sleep-related eating disorder 50.01 11.81 25 121776 325 32391400
Personality change 49.91 11.81 77 121724 4982 32386743
Somnambulism 49.76 11.81 61 121740 3171 32388554
Hypothermia 49.57 11.81 114 121687 9989 32381736
Faecaloma 49.20 11.81 74 121727 4682 32387043
Loss of libido 49.15 11.81 52 121749 2299 32389426
Erythema 49.03 11.81 154 121647 82951 32308774
Productive cough 48.82 11.81 34 121767 34082 32357643
Slow speech 48.42 11.81 36 121765 989 32390736
Oppositional defiant disorder 48.14 11.81 28 121773 501 32391224
Basal cell carcinoma 47.94 11.81 5 121796 17563 32374162
Psychiatric symptom 47.69 11.81 63 121738 3531 32388194
Wrong product administered 47.57 11.81 75 121726 4945 32386780
Derealisation 47.28 11.81 29 121772 574 32391151
Weight decreased 46.65 11.81 394 121407 164424 32227301
Delusional disorder, persecutory type 46.56 11.81 23 121778 291 32391434
Thinking abnormal 46.38 11.81 79 121722 5556 32386169
Blood creatinine increased 46.23 11.81 194 121607 95938 32295787
Cerebrovascular accident 46.12 11.81 167 121634 86153 32305572
Sexually inappropriate behaviour 46.08 11.81 26 121775 438 32391287
Affect lability 45.89 11.81 63 121738 3665 32388060
Upper gastrointestinal haemorrhage 45.85 11.81 16 121785 23833 32367892
Neoplasm progression 45.74 11.81 9 121792 19649 32372076
Blood pressure increased 45.45 11.81 149 121652 79205 32312520
Major depression 45.45 11.81 69 121732 4402 32387323
Haemorrhage 45.25 11.81 72 121729 49376 32342349
Multiple organ dysfunction syndrome 45.15 11.81 124 121677 69730 32321995
Hypersensitivity 44.91 11.81 93 121708 57665 32334060
Aspiration 44.81 11.81 117 121684 11106 32380619
Psychomotor skills impaired 44.76 11.81 51 121750 2452 32389273
Arthritis 44.71 11.81 22 121779 26670 32365055
Myoclonus 44.28 11.81 138 121663 14491 32377234
Chest discomfort 44.23 11.81 75 121726 50155 32341570
Acute myeloid leukaemia 44.15 11.81 9 121792 19165 32372560
Depressive symptom 44.10 11.81 44 121757 1814 32389911
Oedema 43.96 11.81 63 121738 45084 32346641
Hypotonia neonatal 43.69 11.81 36 121765 1153 32390572
Diet refusal 43.59 11.81 23 121778 337 32391388
Colitis ischaemic 43.56 11.81 82 121719 6238 32385487
Diabetic ketoacidosis 43.49 11.81 157 121644 17775 32373950
Temperature regulation disorder 43.17 11.81 27 121774 554 32391171
Hepatic failure 43.08 11.81 42 121759 35638 32356087
Peripheral swelling 42.93 11.81 123 121678 68222 32323503
Vein of Galen aneurysmal malformation 42.92 11.81 11 121790 11 32391714
Tension 42.85 11.81 47 121754 2166 32389559
Lung disorder 42.80 11.81 38 121763 33716 32358009
Bone marrow failure 42.59 11.81 31 121770 30373 32361352
Oropharyngeal spasm 42.58 11.81 18 121783 154 32391571
Dehydration 42.24 11.81 296 121505 128662 32263063
Embolism venous 42.16 11.81 38 121763 1377 32390348
Urinary incontinence 42.13 11.81 157 121644 18050 32373675
Chest pain 42.12 11.81 282 121519 123855 32267870
Granulocytopenia 41.79 11.81 82 121719 6433 32385292
Decreased eye contact 41.70 11.81 25 121776 474 32391251
Arthropathy 41.69 11.81 16 121785 22473 32369252
On and off phenomenon 41.35 11.81 58 121743 3443 32388282
Stereotypy 40.57 11.81 28 121773 682 32391043
Death 40.44 11.81 1108 120693 381409 32010316
Pleurothotonus 40.28 11.81 33 121768 1048 32390677
Dyslipidaemia 39.83 11.81 83 121718 6800 32384925
Atrial septal defect 39.82 11.81 84 121717 6941 32384784
Muscle twitching 39.71 11.81 96 121705 8688 32383037
Clonus 39.70 11.81 49 121752 2565 32389160
Judgement impaired 39.65 11.81 27 121774 643 32391082
Peritonitis 39.58 11.81 17 121784 22313 32369412
Otospondylomegaepiphyseal dysplasia 39.32 11.81 16 121785 123 32391602
Myelodysplastic syndrome 39.29 11.81 13 121788 20025 32371700
Full blood count decreased 39.13 11.81 8 121793 17002 32374723
Poverty of speech 39.13 11.81 19 121782 231 32391494
Suspiciousness 39.07 11.81 22 121779 369 32391356
Grimacing 38.96 11.81 20 121781 276 32391449
Product substitution issue 38.84 11.81 106 121695 10330 32381395
Large for dates baby 38.34 11.81 30 121771 891 32390834
Abdominal discomfort 38.21 11.81 88 121713 52536 32339189
Psoriatic arthropathy 37.91 11.81 10 121791 17850 32373875
Blood bilirubin increased 37.88 11.81 54 121747 38730 32352995
Malignant catatonia 37.87 11.81 18 121783 208 32391517
Trichoglossia 37.44 11.81 16 121785 141 32391584
Electrocardiogram QT interval abnormal 37.34 11.81 14 121787 84 32391641
Cholestasis 37.30 11.81 28 121773 27005 32364720
Multiple drug therapy 37.26 11.81 21 121780 353 32391372
Septic shock 37.15 11.81 133 121668 68856 32322869
Palmar-plantar erythrodysaesthesia syndrome 37.09 11.81 7 121794 15742 32375983
Inflammation 36.95 11.81 23 121778 24470 32367255
Hyperammonaemia 36.93 11.81 74 121727 5895 32385830
Bipolar I disorder 36.89 11.81 29 121772 867 32390858
Psychosexual disorder 36.80 11.81 14 121787 88 32391637
Trismus 36.79 11.81 47 121754 2548 32389177
Gambling disorder 36.72 11.81 40 121761 1829 32389896
Personality disorder 36.70 11.81 33 121768 1192 32390533
Hypoaesthesia 36.66 11.81 105 121696 58248 32333477
Accidental death 36.65 11.81 43 121758 2134 32389591
Excessive eye blinking 36.52 11.81 22 121779 421 32391304
Tic 36.32 11.81 42 121759 2052 32389673
Device related infection 36.29 11.81 11 121790 17922 32373803
Dystonic tremor 36.11 11.81 17 121784 192 32391533
Flushing 36.03 11.81 38 121763 31089 32360636
Abulia 35.69 11.81 23 121778 498 32391227
International normalised ratio increased 35.60 11.81 82 121719 48953 32342772
Peritonitis bacterial 35.58 11.81 3 121798 12493 32379232
Haemoptysis 35.47 11.81 44 121757 33481 32358244
Accidental overdose 35.36 11.81 155 121646 19184 32372541
Brachial plexopathy 35.20 11.81 12 121789 52 32391673
Drooling 35.11 11.81 52 121749 3245 32388480
Pulmonary fibrosis 35.10 11.81 10 121791 16964 32374761
Antipsychotic drug level increased 35.02 11.81 54 121747 3492 32388233
Skin ulcer 34.93 11.81 17 121784 20742 32370983
Tachyphrenia 34.85 11.81 32 121769 1188 32390537
Impulsive behaviour 34.81 11.81 42 121759 2147 32389578
Substance abuse 34.65 11.81 80 121721 7027 32384698
Bronchopulmonary aspergillosis 34.64 11.81 5 121796 13682 32378043
Prostate cancer 34.57 11.81 31 121770 27375 32364350
Dementia with Lewy bodies 34.45 11.81 25 121776 661 32391064
Coordination abnormal 34.30 11.81 84 121717 7664 32384061
Urinary retention 34.14 11.81 240 121561 35457 32356268
Chronic kidney disease 34 11.81 61 121740 39914 32351811
Acute psychosis 33.75 11.81 39 121762 1904 32389821
Electrocardiogram abnormal 33.72 11.81 84 121717 7746 32383979
Hangover 33.70 11.81 30 121771 1069 32390656
Mood altered 33.70 11.81 91 121710 8813 32382912
Sudden cardiac death 33.65 11.81 55 121746 3739 32387986
Fluid retention 33.52 11.81 30 121771 26520 32365205
Libido increased 33.49 11.81 27 121774 838 32390887
Neonatal toxicity 33.20 11.81 10 121791 26 32391699
Diverticulitis 32.92 11.81 15 121786 19013 32372712
Myelosuppression 32.71 11.81 3 121798 11673 32380052
Haematuria 32.64 11.81 84 121717 48277 32343448
Musculoskeletal pain 32.57 11.81 43 121758 31854 32359871
Incoherent 32.40 11.81 59 121742 4375 32387350
Staring 32.34 11.81 34 121767 1492 32390233
Oral discharge 32.13 11.81 14 121787 130 32391595
Rash pruritic 32.06 11.81 27 121774 24584 32367141
Flight of ideas 32.03 11.81 19 121782 353 32391372
Hyperosmolar state 31.86 11.81 20 121781 413 32391312
Hyperammonaemic encephalopathy 31.74 11.81 39 121762 2032 32389693
Haemophagocytic lymphohistiocytosis 31.52 11.81 3 121798 11332 32380393
Neonatal seizure 31.52 11.81 21 121780 482 32391243
Leukopenia 31.37 11.81 354 121447 59768 32331957
Affective disorder 31.04 11.81 51 121750 3482 32388243
Resting tremor 30.77 11.81 23 121778 637 32391088
Prostatic specific antigen increased 30.76 11.81 6 121795 13181 32378544
Gout 30.52 11.81 16 121785 18712 32373013
Pruritus genital 30.47 11.81 22 121779 577 32391148
Blister 30.32 11.81 23 121778 22068 32369657
Blood cholesterol increased 29.98 11.81 139 121662 17618 32374107
Withdrawal arrhythmia 29.96 11.81 10 121791 40 32391685
Synovitis 29.93 11.81 3 121798 10875 32380850
Nephrolithiasis 29.89 11.81 35 121766 27319 32364406
Wheezing 29.83 11.81 58 121743 36816 32354909
Upper respiratory tract infection 29.82 11.81 40 121761 29433 32362292
Respiratory depression 29.80 11.81 113 121688 13098 32378627
Overweight 29.80 11.81 34 121767 1637 32390088
Muscular weakness 29.69 11.81 142 121659 67787 32323938
Neonatal tachypnoea 29.67 11.81 14 121787 159 32391566
Bronchitis 29.66 11.81 70 121731 41437 32350288
Troponin increased 29.36 11.81 93 121708 9849 32381876
Swelling 29.32 11.81 62 121739 38160 32353565
Exposure via ingestion 29.26 11.81 40 121761 2317 32389408
Lymphadenopathy 29.22 11.81 35 121766 27047 32364678
Pyromania 29.21 11.81 10 121791 44 32391681
Hypocalcaemia 29.17 11.81 26 121775 23028 32368697
Screaming 29.07 11.81 31 121770 1383 32390342
Hypertonia 29.02 11.81 59 121742 4750 32386975
Fall 28.95 11.81 950 120851 195251 32196474
Nonspecific reaction 28.81 11.81 30 121771 1302 32390423
Behaviour disorder 28.77 11.81 50 121751 3574 32388151
Galactorrhoea 28.54 11.81 18 121783 375 32391350
Interleukin level increased 28.51 11.81 10 121791 48 32391677
Gastrointestinal disorder 28.33 11.81 45 121756 30886 32360839
Reduced facial expression 28.32 11.81 25 121776 881 32390844
Skin lesion 27.88 11.81 21 121780 20220 32371505
Myalgia 27.79 11.81 184 121617 81046 32310679
Lactic acidosis 27.78 11.81 52 121749 33484 32358241
Blepharospasm 27.71 11.81 27 121774 1081 32390644
Fluid overload 27.48 11.81 20 121781 19601 32372124
Respiratory failure 27.32 11.81 263 121538 106919 32284806
Device dislocation 27.12 11.81 66 121735 5997 32385728
Pseudomonas infection 27.06 11.81 6 121795 12050 32379675
Choreoathetosis 27.02 11.81 26 121775 1025 32390700
Delusional disorder, unspecified type 26.90 11.81 23 121778 776 32390949
Transplant rejection 26.89 11.81 3 121798 9996 32381729
Blood urea increased 26.77 11.81 50 121751 32223 32359502
Hypersomnia 26.73 11.81 102 121699 11859 32379866
Illness anxiety disorder 26.70 11.81 13 121788 159 32391566
Dependence 26.70 11.81 28 121773 1225 32390500
Alcoholism 26.70 11.81 48 121753 3524 32388201
Hypomagnesaemia 26.56 11.81 19 121782 18786 32372939
Haematochezia 26.54 11.81 68 121733 39140 32352585
Oropharyngeal pain 26.52 11.81 48 121753 31304 32360421
Anticonvulsant drug level above therapeutic 26.46 11.81 19 121782 494 32391231
Rash maculo-papular 26.40 11.81 40 121761 27982 32363743
Squamous cell carcinoma of skin 26.29 11.81 3 121798 9823 32381902
Type 1 diabetes mellitus 26.25 11.81 51 121750 3972 32387753
Subgaleal haematoma 26.24 11.81 8 121793 22 32391703
Encephalopathy neonatal 26.22 11.81 9 121792 40 32391685
Illusion 26.18 11.81 23 121778 805 32390920
Cytokine release syndrome 26.15 11.81 9 121792 13526 32378199
Alcohol abuse 25.96 11.81 54 121747 4418 32387307
Melaena 25.95 11.81 57 121744 34608 32357117
Osteonecrosis 25.93 11.81 15 121786 16607 32375118
Rebound effect 25.69 11.81 35 121766 2021 32389704
Neoplasm malignant 25.49 11.81 20 121781 18865 32372860
Cholecystitis 25.34 11.81 4 121797 10241 32381484
Angioedema 25.29 11.81 62 121739 36227 32355498
Nightmare 25.20 11.81 107 121694 13059 32378666
Epilepsy 24.99 11.81 155 121646 21954 32369771
Angina pectoris 24.93 11.81 50 121751 31376 32360349
Fungal infection 24.91 11.81 13 121788 15242 32376483
Freezing phenomenon 24.78 11.81 37 121764 2326 32389399
Penile haemorrhage 24.74 11.81 20 121781 623 32391102
Paraesthesia 24.73 11.81 125 121676 58819 32332906
Atrial flutter 24.70 11.81 13 121788 15170 32376555
Hypoacusis 24.56 11.81 14 121787 15627 32376098
Rectal haemorrhage 24.49 11.81 66 121735 37357 32354368
Tumour lysis syndrome 24.34 11.81 12 121789 14535 32377190
Abdominal distension 24.34 11.81 104 121697 51191 32340534
Angina unstable 24.25 11.81 8 121793 12347 32379378
Alcohol interaction 24.23 11.81 36 121765 2253 32389472
Dyspepsia 24.21 11.81 55 121746 33000 32358725
Stoma site erythema 24.15 11.81 28 121773 1372 32390353
Acute coronary syndrome 24.10 11.81 11 121790 13930 32377795
Penis injury 23.99 11.81 14 121787 252 32391473
Newborn persistent pulmonary hypertension 23.92 11.81 10 121791 83 32391642
Autonomic nervous system imbalance 23.91 11.81 38 121763 2522 32389203
Incontinence 23.86 11.81 60 121741 5566 32386159
Pancreatitis 23.83 11.81 233 121568 37918 32353807
Urine alcohol test positive 23.78 11.81 8 121793 33 32391692
Attention deficit hyperactivity disorder 23.72 11.81 35 121766 2177 32389548
Coagulopathy 23.68 11.81 23 121778 19554 32372171
Cerebral infarction 23.60 11.81 42 121759 27572 32364153
Enuresis 23.59 11.81 34 121767 2070 32389655
Impulse-control disorder 23.47 11.81 29 121772 1520 32390205
Rhinorrhoea 23.45 11.81 31 121770 22955 32368770
Bacteraemia 23.39 11.81 19 121782 17614 32374111
Bone pain 23.36 11.81 25 121776 20319 32371406
Slow response to stimuli 23.09 11.81 21 121780 770 32390955
Salivary gland calculus 22.96 11.81 9 121792 62 32391663
pH body fluid decreased 22.95 11.81 5 121796 0 32391725
Maternal drugs affecting foetus 22.93 11.81 50 121751 4227 32387498
Myoclonic epilepsy 22.92 11.81 23 121778 955 32390770
Feeling jittery 22.88 11.81 48 121753 3951 32387774
COVID-19 22.86 11.81 54 121747 31961 32359764
Gastrointestinal necrosis 22.75 11.81 44 121757 3415 32388310
Renal disorder 22.72 11.81 37 121764 25146 32366579
Lung neoplasm malignant 22.71 11.81 16 121785 15947 32375778
Drug diversion 22.54 11.81 22 121779 883 32390842
Hepatic encephalopathy 22.45 11.81 14 121787 14881 32376844
Refusal of treatment by patient 22.40 11.81 56 121745 5175 32386550
Compartment syndrome 22.37 11.81 37 121764 2540 32389185
Amnesia 22.02 11.81 165 121636 24871 32366854
Cleft lip and palate 22 11.81 15 121786 358 32391367
Mood swings 21.97 11.81 74 121727 8091 32383634
Blunted affect 21.93 11.81 14 121787 298 32391427
Injection site pain 21.86 11.81 58 121743 33000 32358725
Colitis ulcerative 21.85 11.81 19 121782 17032 32374693
Brain injury 21.71 11.81 60 121741 5890 32385835
Vasoplegia syndrome 21.67 11.81 27 121774 1427 32390298
Renal injury 21.65 11.81 9 121792 12046 32379679
Ketoacidosis 21.56 11.81 48 121753 4116 32387609
Cholelithiasis 21.54 11.81 28 121773 20884 32370841
Excessive masturbation 21.39 11.81 10 121791 111 32391614
Epidermolysis bullosa 21.39 11.81 10 121791 111 32391614
Necrotising colitis 21.35 11.81 23 121778 1038 32390687
Haemorrhage intracranial 21.22 11.81 17 121784 15870 32375855
Verbal abuse 21.17 11.81 12 121789 204 32391521
Dizziness 21.08 11.81 611 121190 209007 32182718
Pulmonary mass 21.07 11.81 9 121792 11851 32379874
Congenital cerebrovascular anomaly 21.00 11.81 6 121795 12 32391713
Bacterial parotitis 21.00 11.81 6 121795 12 32391713
Troponin I increased 20.98 11.81 32 121769 2050 32389675
Immune reconstitution inflammatory syndrome 20.97 11.81 5 121796 9554 32382171
Polydipsia 20.89 11.81 45 121756 3772 32387953
Pyramidal tract syndrome 20.86 11.81 12 121789 210 32391515
Hepatotoxicity 20.85 11.81 25 121776 19312 32372413
Colon cancer 20.75 11.81 4 121797 8862 32382863
Osteoarthritis 20.73 11.81 26 121775 19693 32372032
Myoglobin blood increased 20.68 11.81 30 121771 1837 32389888
Patent ductus arteriosus 20.65 11.81 41 121760 3244 32388481
Staphylococcal infection 20.64 11.81 58 121743 32381 32359344
Talipes 20.55 11.81 30 121771 1848 32389877
Distributive shock 20.49 11.81 21 121780 894 32390831
Self-medication 20.42 11.81 34 121767 2347 32389378
Renal tubular necrosis 20.24 11.81 18 121783 15960 32375765
Contraindication to medical treatment 20.17 11.81 16 121785 485 32391240
Treatment failure 20.09 11.81 77 121724 39086 32352639
Acute respiratory failure 20.08 11.81 49 121752 28679 32363046
Condition aggravated 20.01 11.81 742 121059 154919 32236806
Panic attack 19.89 11.81 78 121723 9183 32382542
Eye movement disorder 19.87 11.81 46 121755 4048 32387677
Schizophreniform disorder 19.82 11.81 9 121792 93 32391632
Junctional ectopic tachycardia 19.81 11.81 6 121795 16 32391709
Painful erection 19.77 11.81 12 121789 233 32391492
Pulmonary hypertension 19.55 11.81 29 121772 20465 32371260
Borderline personality disorder 19.43 11.81 14 121787 366 32391359
Parkinsonian rest tremor 19.42 11.81 10 121791 139 32391586
Hepatitis 19.39 11.81 37 121764 23656 32368069
Localised infection 19.36 11.81 17 121784 15170 32376555
Osteomyelitis 19.34 11.81 18 121783 15615 32376110
IVth nerve disorder 19.29 11.81 6 121795 18 32391707
Blood pressure systolic increased 19.29 11.81 22 121779 17374 32374351
Postural orthostatic tachycardia syndrome 19.28 11.81 8 121793 65 32391660
Generalised tonic-clonic seizure 19.28 11.81 138 121663 20501 32371224
Posturing 19.27 11.81 16 121785 518 32391207
Haemangioma congenital 19.24 11.81 16 121785 519 32391206
Flashback 19.17 11.81 10 121791 143 32391582
Skin exfoliation 19.13 11.81 41 121760 25116 32366609
Cholangitis 19.08 11.81 4 121797 8354 32383371
Tooth disorder 19.05 11.81 7 121794 10100 32381625
Dysphonia 19.03 11.81 30 121771 20654 32371071
Abdominal pain upper 19.00 11.81 161 121640 67177 32324548
Brain hypoxia 18.97 11.81 14 121787 380 32391345
Encephalitis toxic 18.94 11.81 12 121789 252 32391473
Ataxia 18.82 11.81 96 121705 12645 32379080
Toxic epidermal necrolysis 18.82 11.81 30 121771 20563 32371162
Acoustic stimulation tests abnormal 18.77 11.81 8 121793 70 32391655
Impaired self-care 18.73 11.81 22 121779 1093 32390632
Hepatitis cholestatic 18.65 11.81 4 121797 8221 32383504
Stoma site infection 18.63 11.81 23 121778 1204 32390521
Phaeochromocytoma malignant 18.58 11.81 8 121793 72 32391653
Stoma site discharge 18.57 11.81 29 121772 1896 32389829
Motor dysfunction 18.49 11.81 60 121741 6436 32385289
Sudden death 18.47 11.81 114 121687 16118 32375607
Parkinsonian gait 18.43 11.81 16 121785 551 32391174
Waxy flexibility 18.42 11.81 9 121792 111 32391614
Influenza like illness 18.42 11.81 47 121754 27093 32364632
Ventricular tachycardia 18.33 11.81 43 121758 25513 32366212
Clostridium difficile colitis 18.32 11.81 16 121785 14315 32377410
Hallucinations, mixed 18.32 11.81 35 121766 2692 32389033
Pulmonary haemorrhage 18.29 11.81 7 121794 9850 32381875
Laboratory test abnormal 18.22 11.81 27 121774 19060 32372665
Feelings of worthlessness 18.19 11.81 11 121790 212 32391513
Pulmonary arterial hypertension 18.18 11.81 7 121794 9814 32381911
Proteinuria 18.12 11.81 23 121778 17332 32374393
Perseveration 18.07 11.81 9 121792 116 32391609
Inappropriate affect 18.07 11.81 16 121785 566 32391159
Retrograde ejaculation 18.07 11.81 13 121788 339 32391386
End stage renal disease 18.04 11.81 4 121797 8033 32383692
Water intoxication 18.00 11.81 15 121786 488 32391237
Intentional product use issue 17.99 11.81 89 121712 42122 32349603
Panic disorder 17.92 11.81 24 121777 1363 32390362
Hepatocellular carcinoma 17.91 11.81 8 121793 10262 32381463
Mental status changes 17.90 11.81 221 121580 38116 32353609
Apraxia 17.84 11.81 23 121778 1258 32390467
Wrong patient 17.74 11.81 9 121792 121 32391604
Self-injurious ideation 17.73 11.81 26 121775 1608 32390117
Vascular stenosis 17.69 11.81 10 121791 169 32391556
Heart rate decreased 17.60 11.81 43 121758 25157 32366568
Patient isolation 17.60 11.81 6 121795 26 32391699
Muscle hypertrophy 17.60 11.81 6 121795 26 32391699
Enteritis 17.59 11.81 3 121798 7258 32384467
Erectile dysfunction 17.59 11.81 131 121670 19708 32372017
Hyperhidrosis 17.58 11.81 369 121432 70799 32320926
Immune thrombocytopenia 17.58 11.81 5 121796 8492 32383233
Orthostatic hypertension 17.57 11.81 11 121790 226 32391499
Rebound psychosis 17.54 11.81 10 121791 172 32391553
Cardiac failure chronic 17.52 11.81 3 121798 7237 32384488
Alcohol use 17.52 11.81 39 121762 3344 32388381
Dysgeusia 17.49 11.81 44 121757 25487 32366238
Laryngospasm 17.47 11.81 24 121777 1397 32390328
Tubulointerstitial nephritis 17.44 11.81 29 121772 19548 32372177
Lower respiratory tract infection 17.36 11.81 54 121747 29189 32362536
Liver function test increased 17.34 11.81 13 121788 12547 32379178
Hernia 17.25 11.81 7 121794 9508 32382217
Unevaluable event 17.25 11.81 66 121735 33520 32358205
Hypercalcaemia 17.18 11.81 16 121785 13878 32377847
Hyperglycaemic hyperosmolar nonketotic syndrome 17.17 11.81 21 121780 1089 32390636
Intercepted medication error 17.15 11.81 15 121786 522 32391203
Camptocormia 17.14 11.81 10 121791 180 32391545
Gynaecomastia 17.13 11.81 72 121729 8747 32382978
Convulsive threshold lowered 17.08 11.81 15 121786 525 32391200
Myocardial ischaemia 17.07 11.81 25 121776 17734 32373991
Prescribed underdose 17.06 11.81 71 121730 8588 32383137
Oral pain 17.05 11.81 8 121793 9970 32381755
Nervousness 17.04 11.81 92 121709 12387 32379338
Muscle spasms 17.01 11.81 175 121626 70243 32321482
Drug resistance 16.99 11.81 38 121763 22927 32368798
Squamous cell carcinoma 16.96 11.81 10 121791 10958 32380767
Substance use 16.96 11.81 15 121786 530 32391195
Antisocial behaviour 16.91 11.81 12 121789 306 32391419
Penoscrotal fusion 16.88 11.81 5 121796 12 32391713
False positive investigation result 16.88 11.81 12 121789 307 32391418
Hypoxia 16.88 11.81 120 121681 52012 32339713
Injection site erythema 16.87 11.81 18 121783 14650 32377075
Gastrointestinal hypomotility 16.85 11.81 20 121781 1005 32390720
Swelling face 16.85 11.81 37 121764 22468 32369257
Diabetes insipidus 16.73 11.81 33 121768 2599 32389126
Anaphylactic shock 16.68 11.81 19 121782 15015 32376710
Psychotic disorder due to a general medical condition 16.65 11.81 7 121794 59 32391666
Hypoalbuminaemia 16.62 11.81 12 121789 11810 32379915
Eosinophilic pleural effusion 16.60 11.81 11 121790 250 32391475
Inappropriate antidiuretic hormone secretion 16.52 11.81 89 121712 11974 32379751
Conduction disorder 16.51 11.81 28 121773 1962 32389763
Lymphoma 16.49 11.81 10 121791 10790 32380935
Kidney duplex 16.42 11.81 13 121788 393 32391332
Movement disorder 16.37 11.81 83 121718 10908 32380817
Sexual abuse 16.36 11.81 9 121792 144 32391581
Polymerase chain reaction 16.35 11.81 8 121793 99 32391626
Ageusia 16.24 11.81 8 121793 9694 32382031
Metastases to bone 16.23 11.81 10 121791 10700 32381025
Negativism 16.22 11.81 13 121788 400 32391325
Compulsions 16.21 11.81 10 121791 200 32391525
Clostridium difficile infection 16.19 11.81 26 121775 17770 32373955
Delirium febrile 16.15 11.81 6 121795 35 32391690
Toxic skin eruption 16.06 11.81 12 121789 11602 32380123
Homicide 16.02 11.81 19 121782 954 32390771
Communication disorder 15.94 11.81 32 121769 2552 32389173
Psychotic behaviour 15.89 11.81 16 121785 667 32391058
Multiple cardiac defects 15.88 11.81 7 121794 67 32391658
Choking 15.88 11.81 49 121752 5117 32386608
Ejection fraction decreased 15.88 11.81 26 121775 17632 32374093
Postmortem blood drug level increased 15.87 11.81 10 121791 208 32391517
Congenital cystic kidney disease 15.86 11.81 13 121788 413 32391312
Mutism 15.86 11.81 17 121784 763 32390962
Erection increased 15.85 11.81 15 121786 579 32391146
Bundle branch block right 15.84 11.81 63 121738 7465 32384260
Memory impairment 15.84 11.81 226 121575 40253 32351472
Congestive cardiomyopathy 15.75 11.81 61 121740 7141 32384584
Pulmonary oedema 15.72 11.81 105 121696 46162 32345563
Lip swelling 15.71 11.81 17 121784 13748 32377977
Stoma site inflammation 15.68 11.81 17 121784 773 32390952
Postoperative respiratory failure 15.67 11.81 8 121793 109 32391616
Laryngeal dyspnoea 15.67 11.81 8 121793 109 32391616
Neonatal infection 15.62 11.81 11 121790 277 32391448
Blood urine present 15.60 11.81 10 121791 10475 32381250
Metastases to lung 15.58 11.81 6 121795 8411 32383314
Somatic symptom disorder 15.55 11.81 15 121786 593 32391132
Crying 15.48 11.81 53 121748 5843 32385882
Hepatic cancer 15.47 11.81 4 121797 7236 32384489
Acute generalised exanthematous pustulosis 15.44 11.81 3 121798 6610 32385115
Neuralgia 15.39 11.81 13 121788 11822 32379903
Blood creatine phosphokinase decreased 15.33 11.81 14 121787 516 32391209
Transposition of the great vessels 15.31 11.81 14 121787 517 32391208
Cerebral amyloid angiopathy 15.30 11.81 8 121793 115 32391610
Hyperglycaemia 15.29 11.81 215 121586 38176 32353549
Gaze palsy 15.28 11.81 22 121779 1338 32390387
Lymphopenia 15.26 11.81 19 121782 14437 32377288
Carbon monoxide poisoning 15.23 11.81 8 121793 116 32391609
Tongue spasm 15.23 11.81 6 121795 42 32391683
Delusional perception 15.14 11.81 9 121792 168 32391557
Feeling guilty 15.12 11.81 11 121790 292 32391433
Maternal exposure during pregnancy 14.98 11.81 43 121758 4314 32387411
Alcohol poisoning 14.92 11.81 36 121765 3253 32388472
Optic discs blurred 14.87 11.81 7 121794 79 32391646
Cerebral disorder 14.84 11.81 31 121770 2544 32389181
Iron deficiency anaemia 14.78 11.81 9 121792 9692 32382033
Urinary tract infection 14.76 11.81 211 121590 79860 32311865
Abscess 14.73 11.81 11 121790 10639 32381086
Leukopenia neonatal 14.72 11.81 4 121797 6 32391719
Breast inflammation 14.60 11.81 5 121796 22 32391703
Antisocial personality disorder 14.60 11.81 5 121796 22 32391703
Somatic delusion 14.60 11.81 8 121793 127 32391598
Obstructive airways disorder 14.53 11.81 14 121787 11947 32379778
Hyperphagia 14.43 11.81 22 121779 1409 32390316
Anomaly of external ear congenital 14.38 11.81 8 121793 131 32391594
Emotional disorder 14.37 11.81 49 121752 5392 32386333
Language disorder 14.36 11.81 26 121775 1919 32389806
Neck pain 14.31 11.81 41 121760 22746 32368979
Faeces discoloured 14.24 11.81 21 121780 14856 32376869
Drug level increased 14.23 11.81 126 121675 19954 32371771
Dry skin 14.22 11.81 47 121754 24931 32366794
Brachial plexus injury 14.14 11.81 7 121794 89 32391636
Yawning 14.09 11.81 14 121787 574 32391151
Flat affect 14.09 11.81 17 121784 869 32390856
Diastolic hypotension 14.09 11.81 5 121796 25 32391700
Delusion of reference 14.09 11.81 5 121796 25 32391700
Status epilepticus 14.09 11.81 85 121716 11921 32379804
Visual acuity reduced 14.06 11.81 25 121776 16420 32375305
Anamnestic reaction 14.03 11.81 6 121795 53 32391672
Xanthoma 14.00 11.81 7 121794 91 32391634
Intermittent explosive disorder 14.00 11.81 4 121797 8 32391717
Enterocolitis 13.98 11.81 5 121796 7335 32384390
Pain in jaw 13.96 11.81 16 121785 12610 32379115
Obsessive thoughts 13.94 11.81 15 121786 676 32391049
Hypophosphataemia 13.85 11.81 8 121793 8867 32382858
Distractibility 13.82 11.81 11 121790 335 32391390
Skin cancer 13.78 11.81 8 121793 8842 32382883
Meconium aspiration syndrome 13.77 11.81 5 121796 27 32391698
Neuroleptic-induced deficit syndrome 13.77 11.81 5 121796 27 32391698
Facial spasm 13.76 11.81 9 121792 200 32391525
Jealous delusion 13.76 11.81 10 121791 265 32391460
Stoma site hypergranulation 13.73 11.81 12 121789 417 32391308
Injection site pruritus 13.73 11.81 3 121798 6087 32385638
Binge eating 13.67 11.81 7 121794 96 32391629
Bladder cancer 13.67 11.81 11 121790 10245 32381480
Post procedural haemorrhage 13.66 11.81 7 121794 8293 32383432
Discomfort 13.65 11.81 24 121777 15831 32375894
Loss of employment 13.62 11.81 13 121788 507 32391218
Neurological symptom 13.60 11.81 37 121764 3598 32388127
Large intestine polyp 13.57 11.81 5 121796 7201 32384524
Oral candidiasis 13.56 11.81 15 121786 12012 32379713
Metabolic encephalopathy 13.56 11.81 40 121761 4075 32387650
Blood alkaline phosphatase increased 13.55 11.81 68 121733 32064 32359661
Haemolysis 13.55 11.81 6 121795 7735 32383990
Respiratory distress 13.53 11.81 77 121724 35169 32356556
Product storage error 13.48 11.81 5 121796 7173 32384552
Shock haemorrhagic 13.47 11.81 12 121789 10633 32381092
Wrong patient received product 13.45 11.81 29 121772 2433 32389292
Divorced 13.39 11.81 4 121797 10 32391715
Helplessness 13.38 11.81 6 121795 60 32391665
Cyanosis neonatal 13.38 11.81 10 121791 277 32391448
Pulmonary alveolar haemorrhage 13.33 11.81 5 121796 7124 32384601
Knee arthroplasty 13.23 11.81 3 121798 5934 32385791
Delusion of grandeur 13.19 11.81 12 121789 440 32391285
Hot flush 13.19 11.81 24 121777 15622 32376103
Stoma site pain 13.16 11.81 17 121784 932 32390793
Dysgraphia 13.04 11.81 25 121776 1928 32389797
Arachnoid cyst 13.01 11.81 9 121792 220 32391505
Device malfunction 12.94 11.81 9 121792 9030 32382695
Malignant melanoma 12.92 11.81 7 121794 8039 32383686
Respiratory fatigue 12.88 11.81 6 121795 66 32391659
Device kink 12.84 11.81 14 121787 641 32391084
Patient uncooperative 12.72 11.81 11 121790 377 32391348
Sexual activity increased 12.69 11.81 5 121796 35 32391690
Small intestinal obstruction 12.67 11.81 21 121780 14175 32377550
Eye pain 12.67 11.81 18 121783 12930 32378795
Appendicitis 12.66 11.81 9 121792 8928 32382797
Hepatitis B 12.63 11.81 4 121797 6337 32385388
Total cholesterol/HDL ratio increased 12.63 11.81 8 121793 168 32391557
Caesarean section 12.62 11.81 26 121775 2113 32389612
Musculoskeletal stiffness 12.60 11.81 212 121589 39052 32352673
Nuchal rigidity 12.60 11.81 12 121789 467 32391258
Feminisation acquired 12.57 11.81 5 121796 36 32391689
Generalised oedema 12.57 11.81 17 121784 12466 32379259
Electroencephalogram abnormal 12.56 11.81 29 121772 2547 32389178
Volvulus 12.56 11.81 20 121781 1330 32390395
Drug dispensed to wrong patient 12.53 11.81 9 121792 234 32391491
Corneal reflex decreased 12.50 11.81 8 121793 171 32391554
Incorrect route of product administration 12.50 11.81 81 121720 11645 32380080
Retrognathia 12.50 11.81 9 121792 235 32391490
Selective mutism 12.50 11.81 6 121795 71 32391654
Sluggishness 12.48 11.81 34 121767 3309 32388416
Hostility 12.47 11.81 16 121785 871 32390854
Gastroenteritis 12.41 11.81 21 121780 14060 32377665
Exposure via body fluid 12.40 11.81 7 121794 118 32391607
Paradoxical drug reaction 12.40 11.81 31 121770 2865 32388860
Glomerular filtration rate decreased 12.34 11.81 18 121783 12793 32378932
Obsessive-compulsive personality disorder 12.34 11.81 8 121793 175 32391550
Nephrotic syndrome 12.33 11.81 6 121795 7323 32384402
Anticholinergic syndrome 12.29 11.81 16 121785 884 32390841
Mixed dementia 12.28 11.81 10 121791 315 32391410
Pressure of speech 12.26 11.81 12 121789 483 32391242
Tendon rupture 12.26 11.81 6 121795 7297 32384428
Pneumothorax 12.25 11.81 30 121771 17540 32374185
Pancreatic carcinoma 12.25 11.81 8 121793 8298 32383427
Haematocrit decreased 12.24 11.81 69 121732 31593 32360132
Cor pulmonale acute 12.24 11.81 9 121792 243 32391482
Ischaemic enteritis 12.19 11.81 4 121797 15 32391710
Anxiolytic therapy 12.19 11.81 4 121797 15 32391710
Gastric ulcer haemorrhage 12.17 11.81 3 121798 5604 32386121
Dysphagia 12.16 11.81 309 121492 61167 32330558
Suspected suicide attempt 12.15 11.81 7 121794 123 32391602
Transfusion 12.13 11.81 7 121794 7761 32383964
Foaming at mouth 12.08 11.81 15 121786 790 32390935
Sciatic nerve neuropathy 12.07 11.81 6 121795 77 32391648
Congenital pulmonary valve atresia 12.07 11.81 6 121795 77 32391648
Oromandibular dystonia 12.02 11.81 12 121789 495 32391230
Flatulence 12.02 11.81 35 121766 19320 32372405
Metastases to central nervous system 11.96 11.81 7 121794 7701 32384024
Enterococcal infection 11.95 11.81 10 121791 9137 32382588
Sciatica 11.93 11.81 3 121798 5531 32386194
Lack of spontaneous speech 11.91 11.81 5 121796 42 32391683
Antipsychotic drug level decreased 11.90 11.81 16 121785 912 32390813
Eye swelling 11.86 11.81 11 121790 9561 32382164
Lymphocyte count decreased 11.84 11.81 40 121761 21079 32370646
Intentional medical device removal by patient 11.81 11.81 11 121790 416 32391309

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37887 adrenergic receptor blockaders
CHEBI has role CHEBI:37956 histamine receptor blocker
CHEBI has role CHEBI:48279 5-hydroxytryptamine antagonists
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:65191 atypical antipsychotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Histone H1.0 Nuclear other Ki 8 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
Transporter Transporter Ki 6.17 CHEMBL

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0123091 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEMBL1200911 ChEMBL_ID
CHEMBL3188993 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0280 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0281 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0282 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0283 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0284 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 32 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1180 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1181 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1182 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1183 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1184 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7986 TABLET, FILM COATED 25 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7987 TABLET, FILM COATED 50 mg ORAL ANDA 33 sections