quetiapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 8226.05 39.74 2236 15931 18798 2321120
Toxicity to various agents 6820.03 39.74 2136 16031 30618 2309300
Drug abuse 3622.52 39.74 1050 17117 10976 2328942
Intentional overdose 2818.36 39.74 854 17313 10467 2329451
Overdose 2810.75 39.74 976 17191 18931 2320987
Suicide attempt 2497.07 39.74 778 17389 10504 2329414
Sopor 2414.96 39.74 606 17561 3389 2336529
Diabetes mellitus 1911.39 39.74 577 17590 6918 2333000
Neuroleptic malignant syndrome 1801.55 39.74 422 17745 1658 2338260
Somnolence 1705.49 39.74 710 17457 22775 2317143
Electrocardiogram QT prolonged 1555.92 39.74 498 17669 7316 2332602
Coma 1543.59 39.74 513 17654 8543 2331375
Intentional self-injury 1473.31 39.74 413 17754 3714 2336204
Drug interaction 1438.16 39.74 672 17495 28491 2311427
Cardio-respiratory arrest 1400.05 39.74 478 17689 8668 2331250
Cardiac arrest 1154.66 39.74 473 17694 14457 2325461
Sedation 1129.38 39.74 321 17846 3041 2336877
Tardive dyskinesia 1105.27 39.74 274 17893 1430 2338488
Exposure during pregnancy 1070.78 39.74 525 17642 24694 2315224
Hypotension 1046.40 39.74 561 17606 31875 2308043
Tachycardia 993.21 39.74 437 17730 15972 2323946
Weight increased 953.70 39.74 467 17700 21870 2318048
Respiratory arrest 913.62 39.74 315 17852 5863 2334055
Gestational diabetes 909.28 39.74 225 17942 1162 2338756
Depressed level of consciousness 901.53 39.74 329 17838 7275 2332643
Confusional state 854.81 39.74 446 17721 23898 2316020
Seizure 762.20 39.74 414 17753 24052 2315866
Poisoning 755.46 39.74 226 17941 2594 2337324
Agitation 732.22 39.74 314 17853 10737 2329181
Type 2 diabetes mellitus 716.23 39.74 205 17962 1989 2337929
Suicidal ideation 714.78 39.74 309 17858 10778 2329140
Loss of consciousness 701.93 39.74 359 17808 18408 2321510
Intentional product misuse 682.99 39.74 286 17881 9203 2330715
Extrapyramidal disorder 667.36 39.74 197 17970 2150 2337768
Dystonia 583.92 39.74 175 17992 2019 2337899
Dyskinesia 555.23 39.74 204 17963 4585 2335333
Psychotic disorder 548.70 39.74 201 17966 4478 2335440
Tremor 529.78 39.74 308 17859 20353 2319565
Death 522.53 39.74 530 17637 80938 2258980
Serotonin syndrome 520.94 39.74 180 17987 3360 2336558
Pancreatitis 506.75 39.74 221 17946 7858 2332060
Leukopenia 500.36 39.74 235 17932 9961 2329957
Anxiety 479.79 39.74 329 17838 29030 2310888
Off label use 462.78 39.74 474 17693 73124 2266794
Akathisia 456.11 39.74 136 18031 1538 2338380
Depression 442.53 39.74 308 17859 27824 2312094
Delirium 442.26 39.74 177 17990 5046 2334872
Fall 441.47 39.74 379 17788 46720 2293198
Muscle rigidity 435.59 39.74 134 18033 1697 2338221
Altered state of consciousness 434.71 39.74 161 18006 3699 2336219
Mania 413.63 39.74 138 18029 2302 2337616
Foetal exposure during pregnancy 403.53 39.74 166 18001 5086 2334832
Obesity 402.08 39.74 121 18046 1415 2338503
Parkinsonism 395.86 39.74 119 18048 1386 2338532
Schizophrenia 394.63 39.74 116 18051 1243 2338675
Neutropenia 386.51 39.74 256 17911 21292 2318626
Drug ineffective 370.96 39.74 495 17672 101129 2238789
Urinary retention 355.13 39.74 137 18030 3530 2336388
Insomnia 342.73 39.74 255 17912 25532 2314386
Dizziness 341.49 39.74 363 17804 58302 2281616
Restlessness 339.58 39.74 141 18026 4422 2335496
Dysarthria 339.34 39.74 155 18012 6147 2333771
Unresponsive to stimuli 337.20 39.74 143 18024 4733 2335185
Blood creatine phosphokinase increased 336.60 39.74 145 18022 4991 2334927
Rhabdomyolysis 330.18 39.74 155 18012 6549 2333369
Restless legs syndrome 328.29 39.74 114 18053 2157 2337761
Sinus tachycardia 324.75 39.74 125 18042 3200 2336718
Aggression 316.53 39.74 136 18031 4650 2335268
Diabetic coma 297.62 39.74 64 18103 149 2339769
Torsade de pointes 287.48 39.74 103 18064 2143 2337775
Hallucination 287.08 39.74 150 18017 7998 2331920
Pneumonia aspiration 279.66 39.74 116 18051 3626 2336292
Condition aggravated 276.26 39.74 246 17921 31733 2308185
Hallucination, auditory 267.34 39.74 97 18070 2095 2337823
Disorientation 267.31 39.74 132 18035 6240 2333678
Circulatory collapse 266.84 39.74 112 18055 3608 2336310
Mydriasis 266.18 39.74 97 18070 2122 2337796
Gait disturbance 257.86 39.74 204 17963 22341 2317577
Pulmonary embolism 256.27 39.74 186 17981 17897 2322021
Blood cholesterol increased 254.40 39.74 120 18047 5121 2334797
Treatment noncompliance 251.21 39.74 121 18046 5413 2334505
Disturbance in attention 248.11 39.74 121 18046 5564 2334354
Bezoar 247.45 39.74 55 18112 158 2339760
Galactorrhoea 242.30 39.74 79 18088 1220 2338698
Anticholinergic syndrome 234.61 39.74 56 18111 240 2339678
Maternal exposure during pregnancy 233.91 39.74 163 18004 14700 2325218
Syncope 230.99 39.74 170 17997 16705 2323213
Ventricular tachycardia 230.60 39.74 95 18072 2916 2337002
Bipolar disorder 229.11 39.74 76 18091 1242 2338676
Bradyphrenia 226.08 39.74 72 18095 1027 2338891
Bradykinesia 226.01 39.74 63 18104 548 2339370
Generalised tonic-clonic seizure 221.48 39.74 110 18057 5262 2334656
Cognitive disorder 218.35 39.74 109 18058 5272 2334646
Hyponatraemia 214.03 39.74 148 18019 13177 2326741
Vomiting 213.15 39.74 317 17850 71285 2268633
Metabolic acidosis 210.02 39.74 110 18057 5888 2334030
Orthostatic hypotension 207.53 39.74 87 18080 2792 2337126
Hyperglycaemia 207.25 39.74 102 18065 4783 2335135
Bradycardia 206.84 39.74 130 18037 9851 2330067
Respiratory failure 202.71 39.74 144 18023 13384 2326534
Speech disorder 199.51 39.74 109 18058 6355 2333563
Coma scale abnormal 199.30 39.74 61 18106 757 2339161
Medication error 199.29 39.74 107 18060 6024 2333894
Delusion 188.71 39.74 74 18093 1991 2337927
Psychomotor hyperactivity 186.71 39.74 72 18095 1850 2338068
Hyperhidrosis 185.83 39.74 144 18023 15278 2324640
Hyperprolactinaemia 185.13 39.74 56 18111 666 2339252
Arrhythmia 184.24 39.74 101 18066 5927 2333991
Accidental overdose 183.73 39.74 88 18079 3884 2336034
Product use in unapproved indication 181.25 39.74 125 18042 11075 2328843
Diabetic ketoacidosis 180.32 39.74 84 18083 3480 2336438
Exposure via ingestion 180.30 39.74 56 18111 732 2339186
Catatonia 180.26 39.74 57 18110 793 2339125
Hypothyroidism 179.98 39.74 90 18077 4367 2335551
Respiratory depression 178.23 39.74 72 18095 2098 2337820
Electrocardiogram QRS complex prolonged 177.48 39.74 60 18107 1042 2338876
Blood prolactin abnormal 176.19 39.74 37 18130 73 2339845
Pyrexia 173.01 39.74 247 17920 53461 2286457
Long QT syndrome 171.10 39.74 50 18117 523 2339395
Ventricular fibrillation 170.41 39.74 70 18097 2131 2337787
Agranulocytosis 169.78 39.74 80 18087 3402 2336516
Labour complication 169.12 39.74 35 18132 62 2339856
Ill-defined disorder 169.00 39.74 79 18088 3299 2336619
Hypotonia 168.73 39.74 65 18102 1665 2338253
Blood triglycerides increased 165.75 39.74 69 18098 2174 2337744
Irritability 164.82 39.74 96 18071 6331 2333587
Sleep disorder 163.96 39.74 96 18071 6393 2333525
Sexual dysfunction 163.95 39.74 43 18124 289 2339629
Drug withdrawal syndrome 162.12 39.74 97 18070 6724 2333194
Cardiometabolic syndrome 161.87 39.74 40 18127 204 2339714
Hypokalaemia 160.93 39.74 114 18053 10540 2329378
Abnormal behaviour 160.10 39.74 85 18082 4675 2335243
Acute kidney injury 159.53 39.74 172 17995 27950 2311968
Poisoning deliberate 157.60 39.74 56 18111 1135 2338783
Myoclonus 155.73 39.74 68 18099 2415 2337503
Dysphagia 155.19 39.74 120 18047 12685 2327233
Psychomotor skills impaired 153.73 39.74 43 18124 379 2339539
Blood glucose increased 150.74 39.74 116 18051 12174 2327744
Mental disorder 150.35 39.74 77 18090 3930 2335988
Salivary hypersecretion 148.56 39.74 54 18113 1171 2338747
Mental status changes 144.77 39.74 84 18083 5498 2334420
Blood prolactin increased 144.34 39.74 51 18116 1016 2338902
Paranoia 142.95 39.74 61 18106 2046 2337872
Hypothermia 141.82 39.74 61 18106 2087 2337831
Hepatic enzyme increased 141.41 39.74 102 18065 9700 2330218
Anosognosia 141.36 39.74 29 18138 48 2339870
Hallucination, visual 140.81 39.74 67 18100 2912 2337006
Pleurothotonus 138.82 39.74 36 18131 230 2339688
Dry mouth 135.59 39.74 93 18074 8160 2331758
Metabolic disorder 133.36 39.74 42 18125 576 2339342
Miosis 130.20 39.74 49 18118 1175 2338743
Balance disorder 128.35 39.74 96 18071 9651 2330267
Thrombocytopenia 128.20 39.74 128 18039 19003 2320915
Withdrawal syndrome 127.73 39.74 65 18102 3272 2336646
Hypersomnia 126.65 39.74 58 18109 2308 2337610
Coma blister 126.24 39.74 23 18144 10 2339908
Disturbance in social behaviour 124.33 39.74 31 18136 165 2339753
Fatigue 121.67 39.74 274 17893 84599 2255319
Nightmare 121.45 39.74 65 18102 3632 2336286
Depressed mood 121.12 39.74 73 18094 5125 2334793
Mood swings 120.27 39.74 62 18105 3207 2336711
Hyperlipidaemia 119.88 39.74 58 18109 2616 2337302
Drug withdrawal syndrome neonatal 119.54 39.74 36 18131 421 2339497
Nausea 118.38 39.74 322 17845 111867 2228051
Hypertension 117.48 39.74 145 18022 27216 2312702
Alanine aminotransferase increased 117.08 39.74 106 18061 13926 2325992
Hypomania 114.62 39.74 40 18127 767 2339151
Constipation 113.41 39.74 127 18040 21502 2318416
Urinary incontinence 113.22 39.74 65 18102 4168 2335750
Substance abuse 113.04 39.74 36 18131 513 2339405
Feeling abnormal 111.08 39.74 131 18036 23450 2316468
Somnambulism 110.79 39.74 40 18127 850 2339068
Hepatic function abnormal 110.48 39.74 73 18094 6019 2333899
Memory impairment 108.55 39.74 98 18069 12825 2327093
Lethargy 108.33 39.74 83 18084 8647 2331271
Muscle twitching 106.23 39.74 54 18113 2711 2337207
Oculogyric crisis 105.83 39.74 31 18136 327 2339591
Drug-induced liver injury 104.85 39.74 59 18108 3640 2336278
Aspartate aminotransferase increased 104.67 39.74 95 18072 12517 2327401
Premature baby 104.31 39.74 56 18111 3148 2336770
Type 1 diabetes mellitus 102.81 39.74 35 18132 621 2339297
White blood cell count decreased 102.52 39.74 111 18056 18097 2321821
Distributive shock 102.22 39.74 23 18144 71 2339847
Caesarean section 102.08 39.74 60 18107 4021 2335897
Panic attack 101.16 39.74 59 18108 3897 2336021
Hepatitis 100.76 39.74 70 18097 6267 2333651
Brain oedema 100.23 39.74 49 18118 2261 2337657
Drug level increased 100.05 39.74 52 18115 2735 2337183
Aspiration 99.41 39.74 43 18124 1491 2338427
Drug screen positive 98.47 39.74 37 18130 883 2339035
Vision blurred 97.98 39.74 98 18069 14570 2325348
Hyperthermia 97.93 39.74 42 18125 1426 2338492
Major depression 97.55 39.74 38 18129 1003 2338915
Palpitations 97.37 39.74 103 18064 16353 2323565
Congestive cardiomyopathy 96.82 39.74 37 18130 926 2338992
Antipsychotic drug level increased 95.65 39.74 32 18135 537 2339381
Musculoskeletal stiffness 95.31 39.74 89 18078 12158 2327760
Dyspnoea 95.20 39.74 238 17929 78495 2261423
Electrocardiogram abnormal 94.67 39.74 40 18127 1308 2338610
Cogwheel rigidity 93.99 39.74 26 18141 219 2339699
Ventricular extrasystoles 92.24 39.74 44 18123 1922 2337996
Gamma-glutamyltransferase increased 92.11 39.74 63 18104 5499 2334419
Acute respiratory distress syndrome 91.93 39.74 52 18115 3240 2336678
Persecutory delusion 91.75 39.74 30 18137 467 2339451
Hypoglycaemia 91.53 39.74 74 18093 8333 2331585
Ileus 91.04 39.74 45 18122 2127 2337791
Drug hypersensitivity 90.78 39.74 171 17996 46472 2293446
Hypokinesia 90.75 39.74 42 18125 1712 2338206
Asthenia 90.04 39.74 171 17996 46755 2293163
Hallucinations, mixed 89.73 39.74 31 18136 576 2339342
Myocarditis 88.26 39.74 37 18130 1186 2338732
Sedation complication 87.76 39.74 23 18144 154 2339764
Drug dependence 87.47 39.74 49 18118 2996 2336922
Personality change 86.94 39.74 34 18133 907 2339011
Cyanosis 85.42 39.74 49 18118 3136 2336782
Movement disorder 85.32 39.74 47 18120 2781 2337137
Pulseless electrical activity 84.44 39.74 34 18133 981 2338937
Amenorrhoea 83.90 39.74 43 18124 2196 2337722
Disorganised speech 83.72 39.74 21 18146 115 2339803
Blood pressure decreased 83.43 39.74 73 18094 9163 2330755
Drug reaction with eosinophilia and systemic symptoms 83.18 39.74 59 18108 5459 2334459
Heart rate increased 83.15 39.74 79 18088 11026 2328892
Parkinson's disease 82.12 39.74 36 18131 1290 2338628
Adverse drug reaction 82.00 39.74 69 18098 8214 2331704
Oedema peripheral 81.83 39.74 113 18054 23650 2316268
Ileus paralytic 81.52 39.74 31 18136 765 2339153
Product substitution issue 80.60 39.74 56 18111 5013 2334905
Neonatal respiratory distress syndrome 80.07 39.74 28 18139 540 2339378
Live birth 79.79 39.74 35 18132 1256 2338662
Liver injury 79.71 39.74 42 18125 2272 2337646
Aphasia 79.66 39.74 55 18112 4873 2335045
Ataxia 79.56 39.74 43 18124 2449 2337469
Drug use disorder 79.43 39.74 25 18142 342 2339576
Suicidal behaviour 78.53 39.74 27 18140 494 2339424
Apathy 78.36 39.74 35 18132 1312 2338606
Psychiatric symptom 78.30 39.74 31 18136 855 2339063
Sleep-related eating disorder 77.91 39.74 20 18147 122 2339796
Pre-eclampsia 77.77 39.74 36 18131 1468 2338450
Sleep apnoea syndrome 77.27 39.74 40 18127 2086 2337832
Alcohol interaction 77.24 39.74 23 18144 258 2339660
Deep vein thrombosis 76.58 39.74 81 18086 12851 2327067
Multiple organ dysfunction syndrome 76.36 39.74 64 18103 7577 2332341
Bundle branch block right 76.03 39.74 30 18137 820 2339098
Bradypnoea 75.31 39.74 25 18142 409 2339509
Oedema 75.28 39.74 72 18095 10131 2329787
Dehydration 75.23 39.74 105 18062 22190 2317728
Eosinophilia 75.15 39.74 44 18123 2926 2336992
Cataract 75.11 39.74 57 18110 5851 2334067
Attention deficit/hyperactivity disorder 74.34 39.74 24 18143 358 2339560
Status epilepticus 74.25 39.74 41 18126 2437 2337481
Abortion spontaneous 73.98 39.74 81 18086 13364 2326554
Hyperammonaemic encephalopathy 73.66 39.74 23 18144 306 2339612
Product prescribing error 72.66 39.74 43 18124 2917 2337001
Muscle spasms 71.92 39.74 101 18066 21465 2318453
Hypertonia 71.68 39.74 32 18135 1198 2338720
Product use issue 71.67 39.74 76 18091 12093 2327825
Schizoaffective disorder 71.31 39.74 21 18146 226 2339692
Asphyxia 71.19 39.74 30 18137 974 2338944
Swollen tongue 71.15 39.74 53 18114 5290 2334628
Personality disorder 70.94 39.74 23 18144 348 2339570
Pallor 70.66 39.74 46 18121 3696 2336222
Sudden death 70.50 39.74 36 18131 1824 2338094
Oromandibular dystonia 69.91 39.74 17 18150 80 2339838
Incontinence 69.61 39.74 33 18134 1421 2338497
Tension 69.46 39.74 25 18142 526 2339392
Rabbit syndrome 69.36 39.74 16 18151 57 2339861
Amnesia 68.89 39.74 59 18108 7194 2332724
Ammonia increased 68.63 39.74 27 18140 732 2339186
Obsessive-compulsive disorder 68.36 39.74 26 18141 642 2339276
Coordination abnormal 68.24 39.74 36 18131 1952 2337966
Hypotonia neonatal 67.76 39.74 20 18147 217 2339701
Abnormal weight gain 67.63 39.74 21 18146 274 2339644
Urinary hesitation 67.51 39.74 20 18147 220 2339698
Hyperreflexia 67.51 39.74 28 18139 873 2339045
Social anxiety disorder 66.56 39.74 16 18151 71 2339847
Drooling 66.08 39.74 26 18141 705 2339213
Homicide 65.90 39.74 17 18150 106 2339812
Blood alkaline phosphatase increased 65.77 39.74 55 18112 6490 2333428
Jaundice 65.33 39.74 51 18116 5457 2334461
Hypertonia neonatal 65.12 39.74 15 18152 53 2339865
Malaise 64.95 39.74 166 18001 55419 2284499
Intestinal obstruction 63.97 39.74 46 18121 4347 2335571
Self-medication 63.78 39.74 24 18143 575 2339343
Headache 63.31 39.74 208 17959 79971 2259947
Renal papillary necrosis 63.03 39.74 14 18153 40 2339878
Colitis ischaemic 62.96 39.74 32 18135 1605 2338313
Depressive symptom 62.40 39.74 23 18144 519 2339399
Electrocardiogram T wave inversion 61.90 39.74 24 18143 625 2339293
Hypoxia 61.89 39.74 52 18115 6175 2333743
Potentiating drug interaction 61.80 39.74 24 18143 628 2339290
Epilepsy 61.73 39.74 46 18121 4593 2335325
Pneumonia 61.55 39.74 151 18016 49145 2290773
Dementia 60.76 39.74 37 18130 2644 2337274
Renal failure 60.45 39.74 83 18084 17266 2322652
Hepatocellular injury 60.29 39.74 43 18124 4012 2335906
Weight decreased 60.15 39.74 108 18059 28263 2311655
Ketoacidosis 60.01 39.74 26 18141 905 2339013
Incorrect dose administered 59.67 39.74 62 18105 9633 2330285
Orthostatic hypertension 59.61 39.74 14 18153 55 2339863
Respiratory disorder neonatal 59.58 39.74 17 18150 162 2339756
Obstructive airways disorder 59.19 39.74 29 18138 1344 2338574
Atrioventricular block first degree 59.06 39.74 26 18141 941 2338977
Mental impairment 58.72 39.74 35 18132 2405 2337513
Congenital hand malformation 58.50 39.74 15 18152 91 2339827
Diabetic neuropathy 58.12 39.74 21 18146 447 2339471
Leukocytosis 58.00 39.74 40 18127 3536 2336382
Small for dates baby 57.76 39.74 23 18144 644 2339274
Congenital thrombocytopenia 57.53 39.74 10 18157 1 2339917
Body temperature increased 57.48 39.74 38 18129 3133 2336785
Gastrointestinal sounds abnormal 57.47 39.74 22 18145 553 2339365
Faecaloma 57.17 39.74 25 18142 890 2339028
Diabetic complication 57.06 39.74 17 18150 191 2339727
Stupor 56.98 39.74 23 18144 668 2339250
Self esteem decreased 56.60 39.74 16 18151 147 2339771
Floppy iris syndrome 56.07 39.74 12 18155 27 2339891
General physical health deterioration 55.96 39.74 72 18095 14067 2325851
Drug level above therapeutic 55.92 39.74 21 18146 500 2339418
Encephalopathy 55.77 39.74 43 18124 4518 2335400
Liver function test abnormal 55.52 39.74 53 18114 7437 2332481
Sudden cardiac death 55.31 39.74 21 18146 516 2339402
Anger 55.28 39.74 34 18133 2473 2337445
Bruxism 55.18 39.74 23 18144 726 2339192
Acidosis 54.82 39.74 29 18138 1581 2338337
Nystagmus 54.64 39.74 26 18141 1129 2338789
Amniotic fluid volume increased 54.36 39.74 12 18155 33 2339885
Nephrogenic diabetes insipidus 53.93 39.74 16 18151 177 2339741
Bradycardia neonatal 53.93 39.74 16 18151 177 2339741
Anaemia of pregnancy 53.10 39.74 12 18155 38 2339880
Bladder dilatation 52.57 39.74 15 18152 143 2339775
Mood altered 52.44 39.74 34 18133 2712 2337206
Merycism 51.95 39.74 11 18156 23 2339895
Hypoglycaemia neonatal 51.93 39.74 16 18151 203 2339715
Behaviour disorder 51.80 39.74 14 18153 107 2339811
Large for dates baby 51.55 39.74 13 18154 73 2339845
Bipolar I disorder 51.48 39.74 18 18149 347 2339571
Mutism 51.27 39.74 17 18150 277 2339641
Hypertriglyceridaemia 51.22 39.74 23 18144 873 2339045
Acute hepatic failure 51.16 39.74 33 18134 2609 2337309
Selective eating disorder 50.81 39.74 18 18149 361 2339557
Pancreatitis acute 50.80 39.74 38 18129 3815 2336103
Thrombotic thrombocytopenic purpura 50.47 39.74 22 18145 777 2339141
Cardiogenic shock 50.43 39.74 32 18135 2459 2337459
Self-injurious ideation 50.43 39.74 20 18147 554 2339364
Pericarditis 50.35 39.74 27 18140 1513 2338405
Alcohol use 50.18 39.74 19 18148 463 2339455
Intestinal pseudo-obstruction 50.18 39.74 14 18153 122 2339796
Logorrhoea 49.92 39.74 19 18148 470 2339448
Ventricular arrhythmia 49.03 39.74 20 18147 597 2339321
Derealisation 48.71 39.74 15 18152 190 2339728
Conjunctival abrasion 48.67 39.74 9 18158 5 2339913
Cardiac failure 48.50 39.74 62 18105 12032 2327886
Chest pain 48.39 39.74 98 18069 28039 2311879
Pancytopenia 47.98 39.74 60 18107 11392 2328526
Dysstasia 47.96 39.74 33 18134 2906 2337012
Burning mouth syndrome 47.79 39.74 12 18155 66 2339852
Injury 47.71 39.74 44 18123 5910 2334008
Affect lability 47.61 39.74 29 18138 2073 2337845
Hepatic failure 47.46 39.74 43 18124 5646 2334272
Respiratory disorder 47.32 39.74 37 18130 3967 2335951
Vertigo 47.26 39.74 54 18113 9330 2330588
Thinking abnormal 47.11 39.74 28 18139 1914 2338004
Transaminases increased 47.02 39.74 39 18128 4548 2335370
Increased appetite 46.39 39.74 25 18142 1415 2338503
Tongue disorder 46.27 39.74 23 18144 1100 2338818
Pharyngitis 45.97 39.74 29 18138 2206 2337712
Sluggishness 45.96 39.74 22 18145 968 2338950
Depersonalisation/derealisation disorder 45.61 39.74 15 18152 238 2339680
Autonomic nervous system imbalance 45.46 39.74 17 18150 400 2339518
Decreased appetite 45.44 39.74 97 18070 28794 2311124
Insurance issue 45.34 39.74 17 18150 403 2339515
Diabetes mellitus inadequate control 45.23 39.74 27 18140 1860 2338058
Resuscitation 45.21 39.74 16 18151 320 2339598
Visual impairment 45.17 39.74 59 18108 11696 2328222
Device stimulation issue 45.01 39.74 8 18159 2 2339916
Hypernatraemia 44.98 39.74 21 18146 873 2339045
Cardiopulmonary failure 44.86 39.74 20 18147 746 2339172
Alcohol poisoning 44.84 39.74 16 18151 328 2339590
Contraindicated product administered 44.82 39.74 32 18135 2989 2336929
Neonatal hypoxia 44.37 39.74 12 18155 92 2339826
Nervous system disorder 43.93 39.74 32 18135 3084 2336834
Anaemia 43.84 39.74 107 18060 34685 2305233
Respiratory acidosis 43.53 39.74 20 18147 801 2339117
Insulin resistance 43.24 39.74 13 18154 151 2339767
Hepatic steatosis 43.06 39.74 32 18135 3181 2336737
Generalised anxiety disorder 42.93 39.74 14 18153 216 2339702
Paraesthesia 42.92 39.74 81 18086 22007 2317911
Tachyphrenia 42.76 39.74 15 18152 292 2339626
Convulsive threshold lowered 42.58 39.74 11 18156 69 2339849
Radial nerve palsy 42.58 39.74 11 18156 69 2339849
Glucose tolerance impaired 42.58 39.74 18 18149 589 2339329
Premature labour 42.50 39.74 27 18140 2079 2337839
Disinhibition 42.46 39.74 14 18153 224 2339694
Drug intolerance 42.42 39.74 62 18105 13655 2326263
Sinus bradycardia 42.38 39.74 27 18140 2089 2337829
Maternal drugs affecting foetus 42.01 39.74 24 18143 1523 2338395
Blood sodium decreased 41.82 39.74 31 18136 3069 2336849
Stereotypy 41.81 39.74 12 18155 117 2339801
Emotional disorder 41.68 39.74 27 18140 2150 2337768
Posture abnormal 41.15 39.74 16 18151 420 2339498
Suppressed lactation 41.10 39.74 12 18155 125 2339793
Myalgia 40.99 39.74 82 18085 23251 2316667
Premature delivery 40.94 39.74 31 18136 3169 2336749
Tic 40.90 39.74 16 18151 427 2339491
Asthma 40.72 39.74 55 18112 11259 2328659
Paralysis 40.64 39.74 25 18142 1819 2338099
Slow response to stimuli 40.64 39.74 13 18154 188 2339730
Pulse absent 40.57 39.74 20 18147 939 2338979
Neonatal disorder 40.47 39.74 14 18153 261 2339657
Physical assault 40.38 39.74 13 18154 192 2339726
Glaucoma 40.15 39.74 26 18141 2069 2337849
Thirst 39.99 39.74 24 18143 1670 2338248
Psychomotor retardation 39.94 39.74 17 18150 566 2339352
Food craving 39.93 39.74 14 18153 272 2339646
Breast enlargement 39.91 39.74 15 18152 358 2339560
Infantile apnoea 39.83 39.74 13 18154 201 2339717

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4475.95 37.10 1380 12055 14932 1718414
Toxicity to various agents 3883.77 37.10 1432 12003 27709 1705637
Neuroleptic malignant syndrome 1989.42 37.10 515 12920 2633 1730713
Drug abuse 1925.16 37.10 705 12730 12984 1720362
Overdose 1672.89 37.10 672 12763 16029 1717317
Suicide attempt 1416.35 37.10 480 12955 6901 1726445
Intentional overdose 1390.46 37.10 478 12957 7192 1726154
Diabetes mellitus 1383.58 37.10 464 12971 6444 1726902
Somnolence 1268.98 37.10 553 12882 16186 1717160
Drug interaction 1085.84 37.10 584 12851 27374 1705972
Sopor 1026.39 37.10 278 13157 1723 1731623
Agitation 826.08 37.10 362 13073 10664 1722682
Coma 799.56 37.10 314 13121 6948 1726398
Sedation 756.41 37.10 248 13187 3169 1730177
Extrapyramidal disorder 749.21 37.10 226 13209 2151 1731195
Aggression 701.45 37.10 295 13140 7820 1725526
Depressed level of consciousness 690.31 37.10 275 13160 6317 1727029
Tardive dyskinesia 641.88 37.10 171 13264 981 1732365
Cardio-respiratory arrest 611.93 37.10 279 13156 9014 1724332
Priapism 610.33 37.10 173 13262 1291 1732055
Electrocardiogram QT prolonged 607.21 37.10 239 13196 5306 1728040
Tachycardia 606.01 37.10 305 13130 12323 1721023
Foetal exposure during pregnancy 578.90 37.10 240 13195 6119 1727227
Dyskinesia 564.37 37.10 205 13230 3614 1729732
Intentional self-injury 547.23 37.10 183 13252 2490 1730856
Blood creatine phosphokinase increased 521.00 37.10 246 13189 8610 1724736
Weight increased 508.82 37.10 262 13173 11095 1722251
Hypotension 491.53 37.10 362 13073 29292 1704054
Rhabdomyolysis 491.48 37.10 254 13181 10836 1722510
Respiratory arrest 486.55 37.10 207 13228 5632 1727714
Off label use 481.50 37.10 398 13037 38173 1695173
Type 2 diabetes mellitus 479.37 37.10 152 13283 1726 1731620
Intentional product misuse 478.06 37.10 219 13216 7139 1726207
Delirium 466.23 37.10 206 13229 6156 1727190
Cardiac arrest 462.17 37.10 276 13159 15654 1717692
Restlessness 461.45 37.10 183 13252 4138 1729208
Psychotic disorder 450.42 37.10 188 13247 4868 1728478
Confusional state 448.21 37.10 301 13134 20977 1712369
Seizure 425.28 37.10 287 13148 20154 1713192
Tremor 408.20 37.10 238 13197 12893 1720453
Dystonia 388.84 37.10 132 13303 1882 1731464
Drug ineffective 372.14 37.10 434 13001 63367 1669979
Poisoning 363.00 37.10 133 13302 2399 1730947
Muscle rigidity 340.62 37.10 117 13318 1731 1731615
Suicidal ideation 337.01 37.10 181 13254 8337 1725009
Loss of consciousness 333.52 37.10 219 13216 14656 1718690
Catatonia 325.86 37.10 95 13340 790 1732556
Insomnia 322.68 37.10 222 13213 16054 1717292
Akathisia 316.24 37.10 102 13333 1226 1732120
Pancreatitis 310.53 37.10 162 13273 7025 1726321
Parkinsonism 301.07 37.10 99 13336 1270 1732076
Condition aggravated 300.67 37.10 236 13199 20914 1712432
Depression 283.28 37.10 207 13228 16462 1716884
Leukopenia 282.69 37.10 161 13274 8319 1725027
Serotonin syndrome 276.41 37.10 112 13323 2676 1730670
Fall 274.16 37.10 249 13186 26965 1706381
Death 273.50 37.10 440 12995 87003 1646343
Schizophrenia 269.43 37.10 101 13334 1945 1731401
Anxiety 268.75 37.10 195 13240 15332 1718014
Diabetic ketoacidosis 268.61 37.10 115 13320 3168 1730178
Oculogyric crisis 265.36 37.10 67 13368 298 1733048
Drug withdrawal syndrome neonatal 245.10 37.10 72 13363 616 1732730
Diabetic coma 245.00 37.10 57 13378 164 1733182
Altered state of consciousness 242.35 37.10 109 13326 3388 1729958
Hallucination 237.59 37.10 142 13293 8028 1725318
Abnormal behaviour 237.44 37.10 130 13305 6212 1727134
Hyperglycaemia 236.18 37.10 121 13314 5044 1728302
Neutropenia 234.30 37.10 192 13243 18068 1715278
Paranoia 231.34 37.10 92 13343 2089 1731257
Poisoning deliberate 222.40 37.10 70 13365 772 1732574
Unresponsive to stimuli 221.99 37.10 112 13323 4517 1728829
Speech disorder 220.92 37.10 111 13324 4437 1728909
Sleep disorder 220.67 37.10 107 13328 3956 1729390
Mania 215.91 37.10 87 13348 2046 1731300
Drug dependence 215.68 37.10 99 13336 3228 1730118
Respiratory disorder neonatal 205.97 37.10 52 13383 231 1733115
Urinary retention 203.06 37.10 111 13324 5284 1728062
Treatment noncompliance 201.27 37.10 109 13326 5092 1728254
Bradyphrenia 195.53 37.10 60 13375 604 1732742
Neonatal respiratory distress syndrome 194.58 37.10 63 13372 766 1732580
Hallucination, auditory 192.61 37.10 80 13355 2037 1731309
Hypertriglyceridaemia 189.97 37.10 68 13367 1141 1732205
Blood triglycerides increased 189.58 37.10 84 13351 2516 1730830
Psychomotor hyperactivity 187.42 37.10 76 13359 1817 1731529
Bezoar 183.66 37.10 42 13393 109 1733237
Pneumonia aspiration 178.10 37.10 101 13334 5165 1728181
Restless legs syndrome 178.08 37.10 62 13373 955 1732391
Blood cholesterol increased 177.38 37.10 84 13351 2942 1730404
Delusion 175.37 37.10 76 13359 2155 1731191
Drug withdrawal syndrome 172.75 37.10 94 13341 4431 1728915
Hyperhidrosis 167.81 37.10 135 13300 12353 1720993
Obesity 166.94 37.10 60 13375 1019 1732327
Urinary incontinence 163.59 37.10 77 13358 2659 1730687
Medication error 163.17 37.10 92 13343 4651 1728695
Sinus tachycardia 163.00 37.10 75 13360 2457 1730889
Dysarthria 162.20 37.10 95 13340 5164 1728182
Miosis 158.99 37.10 63 13372 1415 1731931
Disturbance in attention 158.98 37.10 87 13348 4147 1729199
Stupor 155.92 37.10 50 13385 588 1732758
Bipolar disorder 155.09 37.10 52 13383 710 1732636
Gait disturbance 153.55 37.10 129 13306 12541 1720805
Irritability 152.59 37.10 93 13342 5439 1727907
Accidental overdose 152.04 37.10 84 13351 4080 1729266
Dizziness 150.07 37.10 203 13232 34158 1699188
Selective eating disorder 149.68 37.10 44 13391 377 1732969
Substance abuse 148.53 37.10 54 13381 949 1732397
Disorientation 148.44 37.10 91 13344 5378 1727968
Prescription drug used without a prescription 146.49 37.10 38 13397 192 1733154
Metabolic acidosis 139.29 37.10 87 13348 5315 1728031
Acute kidney injury 132.56 37.10 193 13242 34751 1698595
Small for dates baby 130.23 37.10 43 13392 558 1732788
Syncope 129.47 37.10 123 13312 14046 1719300
Withdrawal syndrome 129.46 37.10 62 13373 2226 1731120
Product use in unapproved indication 128.95 37.10 103 13332 9319 1724027
Mental disorder 128.14 37.10 66 13369 2777 1730569
Hyperthermia 127.66 37.10 56 13379 1635 1731711
Pancreatitis acute 126.46 37.10 74 13361 4013 1729333
Ill-defined disorder 125.09 37.10 57 13378 1824 1731522
Cognitive disorder 122.50 37.10 74 13361 4256 1729090
Aspiration 122.26 37.10 56 13379 1814 1731532
Mental status changes 120.41 37.10 83 13352 5992 1727354
Visceral congestion 120.21 37.10 28 13407 81 1733265
Shock 120.01 37.10 72 13363 4089 1729257
Psychotic symptom 118.88 37.10 32 13403 191 1733155
Hyponatraemia 115.99 37.10 95 13340 8905 1724441
Hallucination, visual 113.44 37.10 59 13376 2533 1730813
Hypothermia 113.19 37.10 52 13383 1696 1731650
Constipation 112.58 37.10 117 13318 14883 1718463
Dysphagia 109.88 37.10 97 13338 10071 1723275
Pyrexia 109.50 37.10 207 13228 46193 1687153
Large for dates baby 108.41 37.10 27 13408 112 1733234
Vomiting 108.36 37.10 185 13250 38130 1695216
Lethargy 107.93 37.10 83 13352 7101 1726245
Depressed mood 107.77 37.10 60 13375 2956 1730390
Drug screen positive 106.54 37.10 43 13392 1014 1732332
Cogwheel rigidity 105.95 37.10 29 13406 186 1733160
Obsessive-compulsive disorder 105.78 37.10 40 13395 788 1732558
Bradycardia 104.97 37.10 96 13339 10438 1722908
Cardiometabolic syndrome 104.69 37.10 31 13404 273 1733073
Bradykinesia 104.16 37.10 35 13400 481 1732865
Atrial septal defect 102.60 37.10 45 13390 1313 1732033
Type 1 diabetes mellitus 101.99 37.10 39 13396 793 1732553
Hypomania 101.60 37.10 35 13400 521 1732825
Respiratory depression 100.78 37.10 52 13383 2195 1731151
Ketoacidosis 100.09 37.10 38 13397 757 1732589
Pulmonary embolism 100.03 37.10 103 13332 12956 1720390
Sudden cardiac death 97.36 37.10 38 13397 818 1732528
Myoclonus 96.89 37.10 51 13384 2244 1731102
Faecaloma 96.74 37.10 36 13399 677 1732669
Sudden death 95.62 37.10 55 13380 2885 1730461
Musculoskeletal stiffness 95.13 37.10 71 13364 5805 1727541
Apathy 94.85 37.10 42 13393 1254 1732092
Inappropriate antidiuretic hormone secretion 94.74 37.10 46 13389 1702 1731644
Gastrointestinal necrosis 93.94 37.10 34 13401 589 1732757
Muscle twitching 93.41 37.10 46 13389 1756 1731590
Hyperprolactinaemia 93.14 37.10 27 13408 219 1733127
Epilepsy 92.67 37.10 60 13375 3899 1729447
Coordination abnormal 92.15 37.10 43 13392 1454 1731892
Exposure via ingestion 91.04 37.10 34 13401 646 1732700
Mydriasis 90.81 37.10 41 13394 1283 1732063
Premature baby 90.29 37.10 53 13382 2889 1730457
Hypertension 89.47 37.10 118 13317 19330 1714016
Social avoidant behaviour 89.40 37.10 33 13402 606 1732740
Blood glucose increased 89.32 37.10 88 13347 10496 1722850
Hangover 88.25 37.10 25 13410 185 1733161
Hypokinesia 87.96 37.10 39 13396 1168 1732178
Acute respiratory distress syndrome 86.03 37.10 55 13380 3496 1729850
Psychomotor retardation 84.78 37.10 29 13406 422 1732924
Aspartate aminotransferase increased 84.46 37.10 86 13349 10670 1722676
Generalised tonic-clonic seizure 84.23 37.10 57 13378 3989 1729357
Disinhibition 84.21 37.10 27 13408 317 1733029
Brugada syndrome 83.94 37.10 25 13410 225 1733121
Euphoric mood 83.87 37.10 34 13401 811 1732535
Sexual dysfunction 81.21 37.10 42 13393 1781 1731565
Vasoplegia syndrome 80.17 37.10 23 13412 179 1733167
Agitation neonatal 79.80 37.10 24 13411 224 1733122
Hepatic enzyme increased 79.27 37.10 67 13368 6554 1726792
Congestive cardiomyopathy 79.01 37.10 36 13399 1151 1732195
Colitis ischaemic 78.87 37.10 33 13402 855 1732491
Hyperlipidaemia 78.69 37.10 44 13391 2185 1731161
Schizoaffective disorder 78.03 37.10 23 13412 199 1733147
Orthostatic hypotension 77.85 37.10 51 13384 3380 1729966
Liver function test abnormal 77.03 37.10 62 13373 5664 1727682
Neonatal behavioural syndrome 76.98 37.10 16 13419 21 1733325
White blood cell count decreased 76.85 37.10 90 13345 13059 1720287
Alanine aminotransferase increased 76.74 37.10 87 13348 12191 1721155
Movement disorder 75.90 37.10 39 13396 1631 1731715
Derealisation 75.51 37.10 21 13414 144 1733202
Homicidal ideation 75.27 37.10 29 13406 602 1732744
Electrocardiogram abnormal 75.14 37.10 35 13400 1178 1732168
Blood pressure decreased 74.81 37.10 69 13366 7577 1725769
Hypotonia neonatal 74.18 37.10 23 13412 240 1733106
Dry mouth 74.09 37.10 52 13383 3861 1729485
Bruxism 74.00 37.10 24 13411 293 1733053
Bundle branch block right 73.74 37.10 35 13400 1230 1732116
Deep vein thrombosis 73.70 37.10 77 13358 9843 1723503
Wrong product administered 73.53 37.10 34 13401 1125 1732221
Alcohol abuse 73.23 37.10 28 13407 569 1732777
Feeling abnormal 72.99 37.10 81 13354 11085 1722261
Increased appetite 72.77 37.10 32 13403 939 1732407
Product substitution issue 72.50 37.10 48 13387 3238 1730108
Refusal of treatment by patient 72.49 37.10 34 13401 1163 1732183
Incontinence 71.08 37.10 32 13403 994 1732352
Oropharyngeal spasm 70.38 37.10 16 13419 40 1733306
Product prescribing error 70.24 37.10 42 13393 2368 1730978
Arrhythmia 70.22 37.10 60 13375 5956 1727390
Amnesia 70.16 37.10 55 13380 4836 1728510
Persecutory delusion 69.94 37.10 25 13410 417 1732929
Anger 68.84 37.10 43 13392 2623 1730723
Antipsychotic drug level below therapeutic 68.26 37.10 20 13415 169 1733177
Loss of personal independence in daily activities 67.83 37.10 41 13394 2358 1730988
Dyslipidaemia 67.75 37.10 29 13406 796 1732550
Logorrhoea 67.23 37.10 25 13410 469 1732877
Poor quality sleep 66.55 37.10 32 13403 1158 1732188
Dysphoria 66.36 37.10 28 13407 741 1732605
Chest pain 65.41 37.10 103 13332 19811 1713535
Distributive shock 65.29 37.10 18 13417 119 1733227
Psychiatric symptom 65.09 37.10 28 13407 778 1732568
Decreased eye contact 64.49 37.10 15 13420 43 1733303
Hypertonia neonatal 64.40 37.10 17 13418 93 1733253
Agranulocytosis 64.18 37.10 46 13389 3530 1729816
Heart rate increased 64.17 37.10 59 13376 6451 1726895
Dehydration 63.14 37.10 95 13340 17563 1715783
Hypersomnia 63.14 37.10 35 13400 1708 1731638
Patent ductus arteriosus 62.88 37.10 26 13409 653 1732693
Coma scale abnormal 62.55 37.10 25 13410 574 1732772
General physical health deterioration 62.47 37.10 81 13354 13037 1720309
Multiple organ dysfunction syndrome 62.05 37.10 68 13367 9174 1724172
Oppositional defiant disorder 61.69 37.10 15 13420 55 1733291
Major depression 61.66 37.10 26 13409 687 1732659
Maternal exposure during pregnancy 61.41 37.10 26 13409 694 1732652
Diet refusal 61.20 37.10 17 13418 116 1733230
Fatigue 61.18 37.10 174 13261 50607 1682739
Vein of Galen aneurysmal malformation 61.17 37.10 11 13424 1 1733345
Intestinal ischaemia 60.97 37.10 29 13406 1024 1732322
Thrombocytopenia 60.46 37.10 103 13332 21146 1712200
Myocarditis 60.28 37.10 35 13400 1868 1731478
Suspiciousness 60.23 37.10 16 13419 90 1733256
Emotional poverty 58.79 37.10 15 13420 70 1733276
Pneumonia 58.32 37.10 161 13274 46021 1687325
Somnambulism 58.31 37.10 25 13410 689 1732657
Hyperammonaemic encephalopathy 58.16 37.10 21 13414 361 1732985
Hepatic function abnormal 58.14 37.10 58 13377 7016 1726330
Hypothyroidism 57.94 37.10 38 13397 2522 1730824
Pulmonary oedema 57.86 37.10 56 13379 6530 1726816
Troponin increased 57.71 37.10 30 13405 1285 1732061
Vertigo 57.69 37.10 47 13388 4366 1728980
Conduction disorder 57.32 37.10 21 13414 377 1732969
Memory impairment 57.31 37.10 56 13379 6607 1726739
Judgement impaired 57.27 37.10 17 13418 151 1733195
Exposure during pregnancy 56.99 37.10 39 13396 2778 1730568
Drug-induced liver injury 56.63 37.10 41 13394 3196 1730150
Mental impairment 56.50 37.10 34 13401 1939 1731407
Accidental death 56.22 37.10 21 13414 399 1732947
Pierre Robin syndrome 56.22 37.10 13 13422 36 1733310
Status epilepticus 55.36 37.10 34 13401 2012 1731334
Parkinson's disease 55.07 37.10 32 13403 1710 1731636
Torticollis 55.07 37.10 19 13416 284 1733062
Hyperreflexia 54.88 37.10 23 13412 598 1732748
Atrioventricular block first degree 54.87 37.10 26 13409 910 1732436
Hypoglycaemia 54.77 37.10 61 13374 8377 1724969
Neonatal seizure 54.74 37.10 16 13419 134 1733212
Salivary hypersecretion 54.67 37.10 30 13405 1435 1731911
Blood prolactin abnormal 54.50 37.10 13 13422 43 1733303
Gynaecomastia 54.07 37.10 34 13401 2098 1731248
Temperature regulation disorder 53.91 37.10 16 13419 142 1733204
Sydenham's chorea 53.86 37.10 10 13425 3 1733343
Slow speech 53.45 37.10 17 13418 194 1733152
Drug level increased 52.79 37.10 37 13398 2740 1730606
Hyperosmolar state 52.52 37.10 14 13421 80 1733266
Alcohol poisoning 52.18 37.10 21 13414 491 1732855
Illness anxiety disorder 51.70 37.10 12 13423 34 1733312
Weight decreased 51.64 37.10 100 13335 22653 1710693
Sleep apnoea syndrome 51.27 37.10 33 13402 2121 1731225
Sedation complication 50.96 37.10 15 13420 129 1733217
Newborn persistent pulmonary hypertension 50.61 37.10 10 13425 8 1733338
Necrotising colitis 50.16 37.10 17 13418 240 1733106
Electrocardiogram QRS complex prolonged 49.99 37.10 23 13412 752 1732594
Ventricular septal defect 49.90 37.10 23 13412 755 1732591
Circulatory collapse 49.74 37.10 39 13396 3428 1729918
Tension 49.66 37.10 18 13417 313 1733033
Blepharospasm 49.34 37.10 17 13418 253 1733093
Respiratory failure 48.96 37.10 76 13359 14429 1718917
Diabetes insipidus 48.93 37.10 19 13416 403 1732943
Drug intolerance 48.52 37.10 49 13386 6013 1727333
Metabolic disorder 48.01 37.10 20 13415 512 1732834
Asthenia 47.89 37.10 125 13310 34545 1698801
Nervousness 47.84 37.10 32 13403 2195 1731151
Product use issue 47.30 37.10 57 13378 8514 1724832
Rash erythematous 47.19 37.10 40 13395 3925 1729421
Trismus 46.92 37.10 20 13415 543 1732803
Prescribed overdose 46.84 37.10 29 13406 1741 1731605
Brachial plexopathy 46.43 37.10 11 13424 35 1733311
Posture abnormal 46.39 37.10 18 13417 381 1732965
Rebound effect 46.32 37.10 16 13419 240 1733106
Apraxia 46.14 37.10 16 13419 243 1733103
Nightmare 45.81 37.10 34 13401 2753 1730593
Enuresis 45.70 37.10 18 13417 397 1732949
Anhedonia 45.67 37.10 22 13413 799 1732547
Renal failure 45.44 37.10 88 13347 19929 1713417
Impulsive behaviour 44.95 37.10 19 13416 505 1732841
Erectile dysfunction 44.78 37.10 41 13394 4456 1728890
Neutrophil count decreased 44.78 37.10 47 13388 6034 1727312
Dementia 44.74 37.10 30 13405 2066 1731280
Disturbance in social behaviour 44.70 37.10 15 13420 205 1733141
Hypokalaemia 44.70 37.10 48 13387 6326 1727020
Abdominal pain 44.60 37.10 91 13344 21399 1711947
Hypernatraemia 44.55 37.10 23 13412 971 1732375
Pleurothotonus 44.40 37.10 14 13421 155 1733191
Intercepted medication error 44.37 37.10 15 13420 210 1733136
Tic 44.37 37.10 21 13414 733 1732613
Abulia 44.25 37.10 13 13422 111 1733235
Dysgraphia 44.16 37.10 16 13419 278 1733068
Oral discharge 43.70 37.10 10 13425 26 1733320
Myoglobin blood increased 43.68 37.10 18 13417 448 1732898
Acute psychosis 43.57 37.10 18 13417 451 1732895
Brain oedema 43.47 37.10 30 13405 2166 1731180
Therapeutic response decreased 43.18 37.10 44 13391 5456 1727890
Interleukin level increased 43.17 37.10 10 13425 28 1733318
Hyperglycaemic hyperosmolar nonketotic syndrome 42.57 37.10 14 13421 179 1733167
Dyspnoea 42.32 37.10 156 13279 51903 1681443
Communication disorder 42.30 37.10 17 13418 396 1732950
Eating disorder 42.07 37.10 24 13411 1238 1732108
Hyperpyrexia 41.96 37.10 19 13416 598 1732748
Feeling jittery 41.65 37.10 21 13414 843 1732503
Antipsychotic drug level above therapeutic 41.03 37.10 14 13421 202 1733144
Maternal drugs affecting foetus 41.01 37.10 23 13412 1148 1732198
Cryptorchism 40.87 37.10 16 13419 347 1732999
Suicidal behaviour 40.53 37.10 16 13419 355 1732991
Respiratory acidosis 39.99 37.10 19 13416 669 1732677
Stereotypy 39.90 37.10 12 13423 112 1733234
Product administration error 39.75 37.10 32 13403 2921 1730425
Behaviour disorder 39.55 37.10 13 13422 166 1733180
Hypoglycaemia neonatal 39.49 37.10 15 13420 299 1733047
Ileus paralytic 39.42 37.10 21 13414 946 1732400
Balance disorder 39.41 37.10 43 13392 5769 1727577
Pupillary reflex impaired 39.41 37.10 16 13419 383 1732963
Encephalopathy 39.37 37.10 38 13397 4414 1728932
Sexually inappropriate behaviour 39.35 37.10 11 13424 77 1733269
Troponin I increased 39.17 37.10 15 13420 306 1733040
Congenital cystic kidney disease 38.99 37.10 11 13424 80 1733266
Polydipsia 38.77 37.10 19 13416 717 1732629
Personality disorder 38.75 37.10 14 13421 241 1733105
Metabolic encephalopathy 38.71 37.10 17 13418 497 1732849
Posturing 38.38 37.10 12 13423 129 1733217
Electrocardiogram QT interval abnormal 38.30 37.10 10 13425 52 1733294
Gastrooesophageal reflux disease 37.99 37.10 38 13397 4609 1728737

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:37887 adrenergic antagonist
CHEBI has role CHEBI:65191 second generation antipsychotic
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Transporter Transporter Ki 6.17 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL

External reference:

IDSource
D000069348 MESH_DESCRIPTOR_UI
4024080 VUID
N0000022085 NUI
C0123091 UMLSCUI
D00458 KEGG_DRUG
2S3PL1B6UJ UNII
111974-72-2 SECONDARY_CAS_RN
108443001 SNOMEDCT_US
4024080 VANDF
006939 NDDF
51272 RXNORM
d04220 MMSL
386850001 SNOMEDCT_US
7467 INN_ID
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEBI:8707 CHEBI
CHEMBL1200911 ChEMBL_ID
CHEMBL3188993 ChEMBL_ID
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 20 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0280 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0281 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0282 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0283 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 20 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0284 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0310-8280 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA authorized generic 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0310-8281 TABLET, FILM COATED, EXTENDED RELEASE 150 mg ORAL NDA authorized generic 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0310-8282 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA authorized generic 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0310-8283 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL NDA authorized generic 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0310-8284 TABLET, FILM COATED, EXTENDED RELEASE 400 mg ORAL NDA authorized generic 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0406-1180 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 20 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0406-1181 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 20 sections