quetiapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2926.44 10.45 2967 151299 142953 46388843
Toxicity to various agents 2666.49 10.45 3380 150886 208386 46323410
Intentional overdose 2250.99 10.45 1800 152466 63144 46468652
Drug abuse 2154.03 10.45 1737 152529 61671 46470125
Sopor 2037.94 10.45 1088 153178 18740 46513056
Suicide attempt 1846.16 10.45 1497 152769 53539 46478257
Overdose 1251.85 10.45 1611 152655 100368 46431428
Intentional self-injury 1251.57 10.45 854 153412 23312 46508484
Neuroleptic malignant syndrome 1144.31 10.45 611 153655 10511 46521285
Sedation 900.70 10.45 685 153581 22225 46509571
Drug interaction 880.75 10.45 2018 152248 201076 46330720
Electrocardiogram QT prolonged 808.81 10.45 921 153345 50404 46481392
Tardive dyskinesia 774.76 10.45 414 153852 7129 46524667
Coma 720.06 10.45 925 153341 57424 46474372
Somnolence 670.83 10.45 1549 152717 154972 46376824
Suicidal ideation 578.33 10.45 817 153449 55565 46476231
Dystonia 578.23 10.45 396 153870 10861 46520935
Psychotic disorder 533.21 10.45 504 153762 22117 46509679
Extrapyramidal disorder 519.52 10.45 371 153895 10897 46520899
Agitation 518.75 10.45 769 153497 54646 46477150
Gestational diabetes 511.72 10.45 311 153955 6908 46524888
Mania 504.42 10.45 359 153907 10487 46521309
Akathisia 495.23 10.45 312 153954 7402 46524394
Depressed level of consciousness 491.78 10.45 692 153574 46877 46484919
Diabetes mellitus 476.13 10.45 700 153566 49365 46482431
Schizophrenia 474.92 10.45 316 153950 8252 46523544
Rheumatoid arthritis 465.90 10.45 111 154155 240104 46291692
Dyskinesia 406.97 10.45 490 153776 28435 46503361
Diarrhoea 382.43 10.45 800 153466 558802 45972994
Arthralgia 375.92 10.45 391 153875 364212 46167584
Tachycardia 364.14 10.45 928 153338 98694 46433102
Parkinsonism 348.80 10.45 254 154012 7694 46524102
Serotonin syndrome 327.21 10.45 402 153864 23818 46507978
Muscle rigidity 327.11 10.45 268 153998 9693 46522103
Poisoning 326.31 10.45 310 153956 13684 46518112
Hallucination 300.78 10.45 569 153697 49382 46482414
Cardio-respiratory arrest 300.51 10.45 632 153634 59237 46472559
Pain 296.72 10.45 717 153549 476231 46055565
Delusion 292.13 10.45 264 154002 10924 46520872
Confusional state 278.76 10.45 1156 153110 158736 46373060
Blood prolactin abnormal 268.32 10.45 115 154151 1174 46530622
Hallucination, auditory 267.54 10.45 247 154019 10509 46521287
Aggression 263.84 10.45 350 153916 22394 46509402
Delirium 262.20 10.45 454 153812 36774 46495022
Restlessness 257.28 10.45 367 153899 25157 46506639
Joint swelling 256.23 10.45 114 154152 165959 46365837
Respiratory arrest 252.15 10.45 423 153843 33393 46498403
Sexual dysfunction 244.22 10.45 131 154135 2272 46529524
Dyspnoea 239.85 10.45 887 153379 514661 46017135
Altered state of consciousness 237.22 10.45 337 153929 23011 46508785
Bipolar disorder 235.45 10.45 193 154073 6984 46524812
Cardiac arrest 223.42 10.45 732 153534 89667 46442129
Bezoar 223.04 10.45 104 154162 1315 46530481
Drug hypersensitivity 219.20 10.45 291 153975 243534 46288262
Anosognosia 217.82 10.45 102 154164 1303 46530493
Exposure during pregnancy 217.18 10.45 818 153448 107394 46424402
Hypomania 215.04 10.45 150 154116 4238 46527558
Tremor 214.84 10.45 853 153413 114786 46417010
Rash 211.16 10.45 549 153717 355963 46175833
Nausea 210.97 10.45 1371 152895 686083 45845713
Abnormal behaviour 209.60 10.45 301 153965 20757 46511039
Seizure 209.09 10.45 883 153383 122171 46409625
Fatigue 206.49 10.45 1176 153090 607521 45924275
Disturbance in social behaviour 206.31 10.45 105 154161 1626 46530170
Bradyphrenia 205.35 10.45 168 154098 6062 46525734
Galactorrhoea 200.71 10.45 136 154130 3661 46528135
Loss of consciousness 196.70 10.45 793 153473 107445 46424351
Psychomotor hyperactivity 188.90 10.45 194 154072 9419 46522377
Pain in extremity 188.64 10.45 355 153911 258325 46273471
Intentional product misuse 186.72 10.45 453 153813 46675 46485121
Cough 183.26 10.45 299 153967 229950 46301846
Sinusitis 176.40 10.45 105 154161 129663 46402133
Headache 173.58 10.45 903 153363 477449 46054347
Pruritus 171.96 10.45 338 153928 242014 46289782
Febrile neutropenia 171.25 10.45 50 154216 94577 46437219
Peripheral swelling 171.09 10.45 162 154104 157909 46373887
Poisoning deliberate 170.50 10.45 168 154098 7758 46524038
Nasopharyngitis 167.64 10.45 157 154109 153841 46377955
Type 2 diabetes mellitus 163.55 10.45 260 154006 19615 46512181
Metabolic disorder 159.86 10.45 126 154140 4306 46527490
Anticholinergic syndrome 157.49 10.45 89 154177 1717 46530079
Diabetic coma 157.31 10.45 68 154198 710 46531086
Labour complication 156.99 10.45 41 154225 59 46531737
Mydriasis 156.99 10.45 184 154082 10369 46521427
Bradykinesia 154.47 10.45 118 154148 3848 46527948
Pneumonia 152.88 10.45 682 153584 375638 46156158
Hyperprolactinaemia 152.56 10.45 104 154162 2828 46528968
Weight increased 151.48 10.45 996 153270 163477 46368319
Paranoia 151.41 10.45 181 154085 10416 46521380
Disorientation 150.67 10.45 359 153907 36559 46495237
Drug intolerance 147.40 10.45 161 154105 146888 46384908
Synovitis 145.37 10.45 16 154250 61059 46470737
Urinary retention 144.74 10.45 287 153979 25774 46506022
Metabolic syndrome 144.68 10.45 75 154191 1209 46530587
Abdominal discomfort 144.48 10.45 172 154094 150993 46380803
Restless legs syndrome 141.16 10.45 215 154051 15628 46516168
Malignant neoplasm progression 140.30 10.45 23 154243 64903 46466893
Disease progression 140.20 10.45 63 154203 91237 46440559
Swelling 140.18 10.45 123 154143 124388 46407408
Dysarthria 137.52 10.45 350 153916 37148 46494648
Blood prolactin increased 135.68 10.45 98 154168 2929 46528867
Treatment failure 135.64 10.45 69 154197 93018 46438778
Back pain 133.87 10.45 311 153955 209728 46322068
Sinus tachycardia 133.21 10.45 249 154017 21400 46510396
Anaemia 132.06 10.45 420 153846 255359 46276437
Personality change 131.25 10.45 121 154145 5137 46526659
Stubbornness 130.75 10.45 43 154223 190 46531606
Hypersensitivity 129.31 10.45 185 154081 150136 46381660
Disturbance in attention 128.89 10.45 307 153959 31253 46500543
Anxiety 128.48 10.45 1034 153232 180923 46350873
Hyperammonaemic encephalopathy 126.78 10.45 80 154186 1902 46529894
Alopecia 123.51 10.45 217 154049 162197 46369599
Infusion related reaction 122.59 10.45 93 154173 101115 46430681
Oculogyric crisis 121.90 10.45 66 154200 1167 46530629
Cardiac failure congestive 116.75 10.45 80 154186 91670 46440126
Drug ineffective 115.97 10.45 1563 152703 676275 45855521
Infection 115.30 10.45 164 154102 133428 46398368
Depression 112.73 10.45 953 153313 169151 46362645
Catatonia 112.69 10.45 96 154170 3666 46528130
Electrocardiogram QRS complex prolonged 112.58 10.45 113 154153 5336 46526460
Malaise 111.22 10.45 641 153625 330591 46201205
Hypotension 110.66 10.45 1215 153051 231374 46300422
Herpes zoster 108.72 10.45 44 154222 67828 46463968
Urticaria 108.55 10.45 138 154128 117754 46414042
Coma scale abnormal 107.47 10.45 106 154160 4900 46526896
Irritability 106.98 10.45 271 153995 28675 46503121
Pleurothotonus 105.91 10.45 59 154207 1106 46530690
Antipsychotic drug level increased 105.03 10.45 86 154180 3106 46528690
Obesity 104.92 10.45 177 154089 14029 46517767
Speech disorder 103.21 10.45 308 153958 35859 46495937
Sepsis 103.14 10.45 182 154084 135832 46395964
Injection site erythema 102.82 10.45 59 154207 74368 46457428
Arthropathy 97.34 10.45 82 154184 84618 46447178
Bipolar I disorder 95.40 10.45 61 154205 1485 46530311
Unresponsive to stimuli 94.67 10.45 277 153989 31897 46499899
Substance abuse 94.64 10.45 91 154175 4076 46527720
Pneumonia aspiration 93.86 10.45 273 153993 31332 46500464
Haemoglobin decreased 93.80 10.45 177 154089 128772 46403024
Persecutory delusion 92.93 10.45 73 154193 2482 46529314
Thinking abnormal 92.87 10.45 137 154129 9677 46522119
Orthostatic hypertension 91.15 10.45 32 154234 179 46531617
Mucosal inflammation 90.77 10.45 11 154255 38965 46492831
Cogwheel rigidity 89.99 10.45 58 154208 1432 46530364
Blood creatine phosphokinase increased 89.68 10.45 247 154019 27477 46504319
Suspected suicide 89.65 10.45 93 154173 4568 46527228
Osteoarthritis 88.82 10.45 47 154219 61978 46469818
Erythema 88.11 10.45 215 154051 142605 46389191
Musculoskeletal pain 88.08 10.45 62 154204 70066 46461730
Hallucinations, mixed 87.31 10.45 84 154182 3765 46528031
Neuropathy peripheral 87.24 10.45 103 154163 90790 46441006
Plasma cell myeloma 87.13 10.45 20 154246 44458 46487338
Cognitive disorder 86.87 10.45 294 153972 36589 46495207
Abdominal pain 86.65 10.45 428 153838 229603 46302193
Urinary tract infection 86.36 10.45 404 153862 219862 46311934
Drug withdrawal syndrome 85.64 10.45 241 154025 27143 46504653
Drug withdrawal syndrome neonatal 85.46 10.45 62 154204 1866 46529930
Contraindicated product administered 85.18 10.45 83 154183 79864 46451932
Psychomotor skills impaired 85.04 10.45 65 154201 2121 46529675
Stomatitis 84.96 10.45 61 154205 68236 46463560
Myoclonus 84.48 10.45 162 154104 14190 46517606
Hallucination, visual 84.21 10.45 184 154082 17689 46514107
Systemic lupus erythematosus 84.03 10.45 56 154210 65124 46466672
Circulatory collapse 83.63 10.45 206 154060 21418 46510378
Mental disorder 82.92 10.45 210 154056 22215 46509581
Torsade de pointes 81.35 10.45 145 154121 12009 46519787
Withdrawal syndrome 80.17 10.45 182 154084 17952 46513844
Injection site pain 79.76 10.45 145 154121 107007 46424789
Salivary hypersecretion 79.09 10.45 102 154164 6343 46525453
Atrial fibrillation 79.07 10.45 138 154128 103452 46428344
Treatment noncompliance 79.04 10.45 247 154019 29484 46502312
Asthenia 78.64 10.45 654 153612 310421 46221375
Hypokinesia 78.27 10.45 137 154129 11185 46520611
Rhabdomyolysis 76.78 10.45 308 153958 41601 46490195
Coma blister 76.62 10.45 26 154240 129 46531667
Foetal exposure during pregnancy 75.88 10.45 249 154017 30498 46501298
Abdominal pain upper 75.30 10.45 238 154028 145067 46386729
Arthritis 74.85 10.45 87 154179 77229 46454567
Influenza 74.63 10.45 112 154154 89158 46442638
Miosis 73.44 10.45 100 154166 6557 46525239
Hand deformity 73.02 10.45 13 154253 34561 46497235
Pemphigus 71.44 10.45 30 154236 45244 46486552
Long QT syndrome 71.34 10.45 68 154198 3012 46528784
Mood swings 70.61 10.45 162 154104 16090 46515706
Bone pain 69.42 10.45 34 154232 46856 46484940
Decreased appetite 69.37 10.45 367 153899 193469 46338327
Pyrexia 69.25 10.45 778 153488 348024 46183772
Embolism venous 69.08 10.45 61 154205 2446 46529350
Bronchitis 68.98 10.45 155 154111 105824 46425972
Somnambulism 68.64 10.45 84 154182 4953 46526843
Cellulitis 68.14 10.45 79 154187 70209 46461587
Platelet count decreased 67.82 10.45 143 154123 99881 46431915
Anger 66.37 10.45 131 154135 11721 46520075
Suicidal behaviour 66.33 10.45 59 154207 2389 46529407
Psychiatric symptom 66.20 10.45 78 154188 4419 46527377
Disorganised speech 65.53 10.45 39 154227 832 46530964
Depersonalisation/derealisation disorder 65.19 10.45 41 154225 969 46530827
Breast cancer 64.42 10.45 35 154231 45483 46486313
Hyperreflexia 64.24 10.45 83 154183 5171 46526625
Panic attack 64.13 10.45 179 154087 20063 46511733
Drug screen positive 63.19 10.45 71 154195 3820 46527976
Accidental overdose 63.14 10.45 177 154089 19889 46511907
Mood altered 62.52 10.45 135 154131 12872 46518924
Pleural effusion 61.95 10.45 112 154154 82840 46448956
Oromandibular dystonia 61.88 10.45 30 154236 416 46531380
Fluid retention 61.66 10.45 47 154219 50999 46480797
Hypotonia 61.39 10.45 103 154163 8126 46523670
Therapeutic product effect decreased 61.26 10.45 112 154154 82489 46449307
Flushing 60.11 10.45 75 154191 64539 46467257
Vomiting 59.89 10.45 1095 153171 451699 46080097
Nightmare 59.87 10.45 154 154112 16444 46515352
Psoriasis 59.71 10.45 105 154161 78499 46453297
Chest pain 59.70 10.45 340 153926 175984 46355812
Skin ulcer 58.97 10.45 17 154249 32441 46499355
Feeling of despair 58.07 10.45 48 154218 1757 46530039
Obsessive-compulsive disorder 58.01 10.45 62 154204 3153 46528643
Derealisation 57.94 10.45 35 154231 768 46531028
Respiratory depression 57.60 10.45 122 154144 11478 46520318
Gastrointestinal haemorrhage 57.30 10.45 105 154161 77268 46454528
Injection site pruritus 57.06 10.45 30 154236 39713 46492083
Pancreatitis 56.93 10.45 290 153976 43337 46488459
Bone marrow failure 56.81 10.45 14 154252 29655 46502141
Tachyphrenia 55.97 10.45 41 154225 1253 46530543
Exposure via ingestion 55.86 10.45 63 154203 3404 46528392
Apathy 55.59 10.45 92 154174 7176 46524620
Osteonecrosis of jaw 55.57 10.45 22 154244 34380 46497416
Chills 55.02 10.45 150 154116 95882 46435914
Hypotonia neonatal 54.99 10.45 35 154231 845 46530951
Myocardial infarction 54.64 10.45 154 154112 97374 46434422
Logorrhoea 54.49 10.45 52 154214 2307 46529489
Impulse-control disorder 54.22 10.45 32 154234 672 46531124
Blood triglycerides increased 54.03 10.45 120 154146 11663 46520133
Schizoaffective disorder 53.92 10.45 42 154224 1410 46530386
Impaired healing 53.85 10.45 27 154239 36716 46495080
Upper respiratory tract infection 53.83 10.45 79 154187 63477 46468319
Pancytopenia 53.25 10.45 127 154139 84931 46446865
Major depression 52.95 10.45 86 154180 6604 46525192
Injection site swelling 52.85 10.45 34 154232 40293 46491503
Dyspnoea exertional 52.65 10.45 53 154213 50236 46481560
Generalised tonic-clonic seizure 52.64 10.45 203 154063 26919 46504877
Psychomotor retardation 52.52 10.45 59 154207 3174 46528622
Distributive shock 51.82 10.45 28 154238 493 46531303
Lower respiratory tract infection 51.18 10.45 64 154202 55025 46476771
Abnormal weight gain 51.12 10.45 41 154225 1437 46530359
Chest discomfort 50.97 10.45 142 154124 90127 46441669
Therapeutic product effect incomplete 50.28 10.45 115 154151 78038 46453758
Stupor 50.08 10.45 60 154206 3460 46528336
Faecaloma 49.99 10.45 91 154175 7661 46524135
Enuresis 49.87 10.45 46 154220 1954 46529842
Drug level increased 49.74 10.45 154 154112 18287 46513509
Inflammation 49.28 10.45 53 154213 48728 46483068
Hypothermia 49.18 10.45 118 154148 12065 46519731
Mutism 49.14 10.45 38 154228 1262 46530534
Affect lability 49.02 10.45 92 154174 7928 46523868
Device expulsion 48.98 10.45 15 154251 27527 46504269
Depressed mood 48.85 10.45 229 154037 33090 46498706
Osteonecrosis 47.66 10.45 13 154253 25731 46506065
Red blood cell sedimentation rate increased 47.49 10.45 9 154257 22880 46508916
Sleep-related eating disorder 47.31 10.45 28 154238 591 46531205
Palmar-plantar erythrodysaesthesia syndrome 47.06 10.45 6 154260 20445 46511351
Amenorrhoea 47.03 10.45 96 154170 8799 46522997
Interstitial lung disease 46.73 10.45 66 154200 53883 46477913
Dementia 46.29 10.45 131 154135 14799 46516997
Myalgia 46.29 10.45 229 154037 122859 46408937
Gastrointestinal disorder 45.77 10.45 79 154187 59497 46472299
Rabbit syndrome 45.64 10.45 22 154244 301 46531495
Knee arthroplasty 45.64 10.45 11 154255 23654 46508142
Hypersomnia 45.48 10.45 133 154133 15306 46516490
Intestinal pseudo-obstruction 45.38 10.45 28 154238 639 46531157
Bundle branch block right 45.20 10.45 67 154199 4752 46527044
Electrocardiogram QRS complex shortened 45.02 10.45 23 154243 359 46531437
Medication error 44.99 10.45 212 154054 30699 46501097
Rheumatoid factor positive 44.75 10.45 7 154259 20454 46511342
Anaemia of pregnancy 44.61 10.45 15 154251 72 46531724
Parkinsonian gait 44.53 10.45 25 154241 476 46531320
Diverticulitis 44.47 10.45 27 154239 33012 46498784
Prescribed overdose 44.12 10.45 103 154163 10346 46521450
Productive cough 43.97 10.45 62 154204 50653 46481143
Sympathomimetic effect 43.92 10.45 13 154253 37 46531759
Muscle twitching 43.80 10.45 127 154139 14545 46517251
Bradypnoea 43.56 10.45 52 154214 2987 46528809
Epistaxis 43.52 10.45 92 154174 64213 46467583
Bursitis 42.92 10.45 7 154259 19835 46511961
Psychiatric decompensation 42.83 10.45 33 154233 1090 46530706
Basal cell carcinoma 42.62 10.45 8 154258 20479 46511317
Orthostatic hypotension 42.61 10.45 178 154088 24480 46507316
Cytomegalovirus infection 42.54 10.45 5 154261 18139 46513657
Acute psychosis 42.43 10.45 42 154224 1950 46529846
Tension 42.30 10.45 50 154216 2842 46528954
Nephrogenic diabetes insipidus 41.93 10.45 28 154238 735 46531061
Oropharyngeal pain 41.62 10.45 117 154149 74051 46457745
Prescribed underdose 41.60 10.45 110 154156 11943 46519853
Injection site bruising 41.54 10.45 34 154232 35602 46496194
Bradycardia 41.50 10.45 367 153899 65931 46465865
Ascites 41.30 10.45 36 154230 36548 46495248
Ataxia 41.03 10.45 120 154146 13810 46517986
Injection site reaction 40.98 10.45 59 154207 47790 46484006
Coronary artery disease 40.86 10.45 31 154235 33721 46498075
Adjustment disorder with mixed anxiety and depressed mood 40.85 10.45 14 154252 72 46531724
Weight decreased 40.69 10.45 473 153793 210376 46321420
Granulocytopenia 40.67 10.45 67 154199 5206 46526590
Renal failure 40.63 10.45 215 154051 113379 46418417
Gastrooesophageal reflux disease 40.46 10.45 119 154147 74225 46457571
Postural tremor 40.30 10.45 16 154250 132 46531664
Schizophreniform disorder 40.17 10.45 13 154253 54 46531742
Hyperkinesia 40.07 10.45 39 154227 1773 46530023
Impulsive behaviour 40.03 10.45 36 154230 1479 46530317
Fluid overload 39.80 10.45 20 154246 27165 46504631
Glossodynia 39.72 10.45 53 154213 44320 46487476
Drooling 39.71 10.45 51 154215 3158 46528638
Urine osmolarity increased 39.65 10.45 15 154251 107 46531689
Pulmonary arterial hypertension 39.61 10.45 18 154248 25910 46505886
Nasal congestion 39.58 10.45 61 154205 48052 46483744
Dyspepsia 39.18 10.45 107 154159 68365 46463431
Hypersexuality 38.97 10.45 23 154243 483 46531313
Homicide 38.95 10.45 22 154244 424 46531372
Negativism 38.80 10.45 21 154245 371 46531425
Anti-cyclic citrullinated peptide antibody positive 38.73 10.45 8 154258 19137 46512659
Drug dependence 38.66 10.45 149 154117 19752 46512044
Amniotic fluid volume increased 38.61 10.45 16 154250 149 46531647
Hyperthermia 38.31 10.45 83 154183 7931 46523865
Aspiration 38.13 10.45 92 154174 9439 46522357
Tic 37.96 10.45 32 154234 1204 46530592
Self-medication 37.94 10.45 41 154225 2111 46529685
Full blood count decreased 37.90 10.45 13 154253 22198 46509598
Mobility decreased 37.50 10.45 91 154175 60503 46471293
Behaviour disorder 37.48 10.45 39 154227 1922 46529874
Potentiating drug interaction 37.46 10.45 55 154211 3868 46527928
Urinary hesitation 37.41 10.45 38 154228 1820 46529976
Conjunctival abrasion 37.24 10.45 11 154255 31 46531765
Clonus 37.23 10.45 56 154210 4024 46527772
Dissociation 37.09 10.45 38 154228 1839 46529957
Gastric pH decreased 37.02 10.45 20 154246 352 46531444
Throat irritation 37.01 10.45 25 154241 28876 46502920
Thrombocytopenia 36.67 10.45 256 154010 126325 46405471
Depressive symptom 36.56 10.45 46 154220 2790 46529006
Thrombosis 36.47 10.45 82 154184 55987 46475809
Insomnia 36.24 10.45 755 153511 164169 46367627
Social anxiety disorder 36.18 10.45 20 154246 369 46531427
Rectal haemorrhage 36.00 10.45 44 154222 38211 46493585
Osteoporosis 35.84 10.45 49 154217 40559 46491237
Infarction 35.69 10.45 41 154225 2260 46529536
Posture abnormal 35.63 10.45 40 154226 2150 46529646
Lung disorder 35.53 10.45 55 154211 43249 46488547
Congenital hand malformation 35.35 10.45 18 154248 279 46531517
Hyperthermia malignant 35.29 10.45 25 154241 724 46531072
Tongue biting 35.23 10.45 32 154234 1332 46530464
Clostridium difficile colitis 35.05 10.45 9 154257 18544 46513252
Borderline personality disorder 35.02 10.45 25 154241 733 46531063
Renal papillary necrosis 34.92 10.45 17 154249 238 46531558
Dry skin 34.71 10.45 51 154215 40965 46490831
Leukopenia 34.71 10.45 362 153904 67981 46463815
Asthma 34.58 10.45 170 154096 91372 46440424
Myocarditis 34.57 10.45 78 154188 7661 46524135
Oedema peripheral 34.52 10.45 349 153917 159357 46372439
Hyperphagia 34.43 10.45 34 154232 1574 46530222
Stereotypy 34.36 10.45 20 154246 409 46531387
Congenital thrombocytopenia 34.32 10.45 11 154255 44 46531752
Anaphylactic reaction 34.28 10.45 78 154188 53034 46478762
Attention deficit hyperactivity disorder 34.20 10.45 39 154227 2133 46529663
Pain in jaw 34.18 10.45 46 154220 38326 46493470
Rhinorrhoea 34.12 10.45 66 154200 47599 46484197
Localised infection 34.12 10.45 18 154248 23783 46508013
Acute kidney injury 34.08 10.45 561 153705 235294 46296502
Jaundice cholestatic 33.66 10.45 60 154206 4969 46526827
Electrocardiogram repolarisation abnormality 33.31 10.45 30 154236 1235 46530561
Disinhibition 33.07 10.45 26 154240 885 46530911
Action tremor 33.06 10.45 16 154250 221 46531575
Neoplasm progression 32.95 10.45 24 154242 26659 46505137
Homicidal ideation 32.95 10.45 35 154231 1767 46530029
Surgery 32.89 10.45 28 154238 28757 46503039
Metastases to liver 32.50 10.45 12 154254 19573 46512223
Self esteem decreased 32.49 10.45 21 154245 521 46531275
Hypertension 32.48 10.45 455 153811 195901 46335895
Product substitution issue 32.08 10.45 116 154150 14915 46516881
Alcohol interaction 32.07 10.45 40 154226 2405 46529391
Metastases to bone 32.03 10.45 9 154257 17467 46514329
Chorea 31.94 10.45 28 154238 1112 46530684
Ventricular fibrillation 31.93 10.45 97 154169 11399 46520397
Gastrointestinal sounds abnormal 31.82 10.45 48 154218 3458 46528338
Drug level above therapeutic 31.79 10.45 48 154218 3461 46528335
Renal impairment 31.75 10.45 132 154134 74240 46457556
Laboratory test abnormal 31.70 10.45 18 154248 22829 46508967
Electrocardiogram abnormal 31.69 10.45 71 154195 6941 46524855
Sleep disorder 31.36 10.45 263 154003 46532 46485264
Femur fracture 31.31 10.45 46 154220 36951 46494845
Acute myeloid leukaemia 31.09 10.45 7 154259 15771 46516025
Hypertonia 30.81 10.45 54 154212 4412 46527384
Wrong patient received product 30.46 10.45 33 154233 1704 46530092
Meconium in amniotic fluid 30.45 10.45 14 154252 171 46531625
Merycism 30.39 10.45 13 154253 132 46531664
Accidental poisoning 30.39 10.45 21 154245 584 46531212
Viral infection 30.37 10.45 33 154233 30202 46501594
Joint stiffness 30.21 10.45 27 154239 27081 46504715
Formication 30.15 10.45 50 154216 3906 46527890
Torticollis 30.00 10.45 33 154233 1734 46530062
Emotional poverty 29.95 10.45 16 154250 275 46531521
Polydipsia 29.91 10.45 45 154221 3234 46528562
Hypertonia neonatal 29.72 10.45 15 154251 228 46531568
Psychotic behaviour 29.62 10.45 21 154245 609 46531187
Product quality issue 29.51 10.45 45 154221 35603 46496193
Wheezing 29.37 10.45 85 154181 53301 46478495
Conversion disorder 29.33 10.45 32 154234 1666 46530130
Feeling guilty 29.30 10.45 19 154247 474 46531322
Food craving 29.01 10.45 27 154239 1160 46530636
Cardiac failure 28.76 10.45 151 154115 79797 46451999
Peripartum cardiomyopathy 28.66 10.45 12 154254 115 46531681
Drug use disorder 28.54 10.45 40 154226 2695 46529101
No adverse event 28.54 10.45 43 154223 34188 46497608
Arrhythmia 28.43 10.45 205 154061 34636 46497160
Floppy iris syndrome 28.39 10.45 12 154254 118 46531678
Ventricular tachycardia 28.16 10.45 121 154145 16846 46514950
Herbal interaction 28.04 10.45 10 154256 59 46531737
Pulmonary mass 27.90 10.45 12 154254 17845 46513951
Pyramidal tract syndrome 27.89 10.45 16 154250 318 46531478
Osteomyelitis 27.81 10.45 20 154246 22363 46509433
Akinesia 27.78 10.45 32 154234 1769 46530027
Antidepressant drug level increased 27.76 10.45 15 154251 264 46531532
Dehydration 27.71 10.45 366 153900 159174 46372622
Hyperkalaemia 27.71 10.45 81 154185 50628 46481168
Bone disorder 27.48 10.45 16 154250 20017 46511779
Euphoric mood 27.36 10.45 50 154216 4222 46527574
Breast cancer metastatic 27.09 10.45 6 154260 13672 46518124
Nuchal rigidity 26.62 10.45 19 154247 557 46531239
Colitis 26.48 10.45 52 154214 37295 46494501
Respiratory disorder neonatal 26.41 10.45 23 154243 905 46530891
Neonatal respiratory distress syndrome 26.37 10.45 37 154229 2496 46529300
Blood pressure increased 26.05 10.45 280 153986 126386 46405410
Bladder dilatation 26.04 10.45 21 154245 742 46531054
Hip arthroplasty 25.52 10.45 14 154252 18098 46513698
Neoplasm malignant 25.48 10.45 24 154242 23475 46508321
Congenital hearing disorder 25.37 10.45 7 154259 14 46531782
Loss of personal independence in daily activities 25.35 10.45 100 154166 57083 46474713
Nephrolithiasis 25.23 10.45 44 154222 33007 46498789
Mouth ulceration 25.10 10.45 31 154235 26801 46504995
Sedation complication 25.05 10.45 44 154222 3601 46528195
Oral pain 24.97 10.45 27 154239 24770 46507026
Night sweats 24.95 10.45 32 154234 27218 46504578
Alcohol poisoning 24.91 10.45 34 154232 2234 46529562
Mental impairment 24.80 10.45 94 154172 12362 46519434
Insurance issue 24.79 10.45 30 154236 1748 46530048
Respiratory tract infection 24.65 10.45 38 154228 29934 46501862
Psoriatic arthropathy 24.65 10.45 52 154214 36327 46495469
Rash pruritic 24.61 10.45 70 154196 44145 46487651
Septic shock 24.56 10.45 103 154163 57790 46474006
Self-injurious ideation 24.54 10.45 34 154232 2266 46529530
Slow response to stimuli 24.45 10.45 21 154245 811 46530985
Neonatal disorder 24.39 10.45 19 154247 638 46531158
Musculoskeletal discomfort 24.38 10.45 8 154258 14048 46517748
Ear infection 24.37 10.45 24 154242 22989 46508807
Sudden death 24.37 10.45 78 154188 9426 46522370
Flatulence 24.34 10.45 36 154230 28842 46502954
Apnoea 24.34 10.45 66 154200 7273 46524523
Joint effusion 24.29 10.45 5 154261 11990 46519806
Hypoglycaemia neonatal 24.22 10.45 22 154244 916 46530880
Chronic obstructive pulmonary disease 24.16 10.45 103 154163 57530 46474266
Hostility 24.10 10.45 26 154240 1336 46530460
Ammonia increased 24.05 10.45 48 154218 4329 46527467
Myelodysplastic syndrome 23.85 10.45 11 154255 15700 46516096
Small for dates baby 23.84 10.45 43 154223 3594 46528202
Type 1 diabetes mellitus 23.84 10.45 38 154228 2872 46528924
Suppressed lactation 23.76 10.45 16 154250 426 46531370
Tonic clonic movements 23.65 10.45 24 154242 1148 46530648
Adrenal insufficiency 23.60 10.45 7 154259 13117 46518679
Disseminated intravascular coagulation 23.59 10.45 17 154249 18988 46512808
Language disorder 23.39 10.45 27 154239 1496 46530300
Product dose omission issue 23.29 10.45 404 153862 168116 46363680
Bradycardia neonatal 23.17 10.45 18 154248 602 46531194
Generalised anxiety disorder 23.13 10.45 28 154238 1632 46530164
Foot deformity 23.11 10.45 11 154255 15414 46516382
Discomfort 23.07 10.45 78 154188 46592 46485204
Bacteraemia 23.01 10.45 9 154257 14170 46517626
Electrocardiogram QT interval abnormal 22.92 10.45 11 154255 149 46531647
Reduced facial expression 22.85 10.45 24 154242 1196 46530600
Anaphylactic shock 22.82 10.45 20 154246 20254 46511542
Burning sensation 22.79 10.45 73 154193 44338 46487458
Liver injury 22.74 10.45 109 154157 15892 46515904
Haemoptysis 22.71 10.45 32 154234 26157 46505639
Cervix neoplasm 22.63 10.45 12 154254 203 46531593
Injection site rash 22.60 10.45 12 154254 15801 46515995
Negative thoughts 22.58 10.45 20 154246 805 46530991
Burning mouth syndrome 22.49 10.45 15 154251 393 46531403
Depressive delusion 22.44 10.45 6 154260 10 46531786
Device stimulation issue 22.38 10.45 9 154257 77 46531719
Amnesia 22.32 10.45 223 154043 41408 46490388
Neurological decompensation 22.29 10.45 29 154237 1819 46529977
Injection site urticaria 22.23 10.45 6 154260 11961 46519835
Disturbance in sexual arousal 22.08 10.45 9 154257 80 46531716
Nodule 22.07 10.45 12 154254 15593 46516203
Inappropriate affect 22.07 10.45 20 154246 830 46530966
Agranulocytosis 21.99 10.45 137 154129 22048 46509748
Status epilepticus 21.91 10.45 98 154168 13881 46517915
Fungal infection 21.90 10.45 40 154226 29480 46502316
Haemorrhoids 21.78 10.45 18 154248 18759 46513037
Gastritis 21.77 10.45 51 154215 34327 46497469
Urine sodium increased 21.70 10.45 9 154257 84 46531712
Resting tremor 21.70 10.45 18 154248 662 46531134
Limb discomfort 21.63 10.45 26 154240 22750 46509046
Hypoaesthesia 21.63 10.45 270 153996 118599 46413197
Spasmodic dysphonia 21.61 10.45 9 154257 85 46531711
Decreased interest 21.60 10.45 38 154228 3114 46528682
Drug screen false positive 21.53 10.45 20 154246 857 46530939
Bruxism 21.49 10.45 37 154229 2980 46528816
Clostridium difficile infection 21.45 10.45 31 154235 25072 46506724
Metabolic acidosis 21.41 10.45 209 154057 38571 46493225
Neutropenic sepsis 21.40 10.45 7 154259 12317 46519479
Tongue spasm 21.40 10.45 8 154258 55 46531741
Neck pain 21.29 10.45 102 154164 55204 46476592
Malignant melanoma 21.28 10.45 4 154262 10230 46521566
Melaena 21.17 10.45 37 154229 27735 46504061
Physical assault 21.07 10.45 21 154245 983 46530813
Tongue movement disturbance 21.02 10.45 11 154255 181 46531615
Infective pulmonary exacerbation of cystic fibrosis 20.88 10.45 5 154261 10802 46520994
Seasonal allergy 20.77 10.45 9 154257 13325 46518471
Pulmonary hypertension 20.77 10.45 56 154210 35937 46495859
Colitis ulcerative 20.56 10.45 17 154249 17715 46514081
Cerebellar atrophy 20.53 10.45 17 154249 624 46531172
Thermal burn 20.51 10.45 48 154218 4829 46526967
Right ventricular failure 20.50 10.45 14 154252 16079 46515717
False positive investigation result 20.47 10.45 16 154250 540 46531256
Social avoidant behaviour 20.47 10.45 35 154231 2804 46528992
Neuropsychiatric symptoms 20.46 10.45 15 154251 459 46531337
Selective eating disorder 20.45 10.45 27 154239 1718 46530078
Swelling face 20.34 10.45 98 154168 52961 46478835
Vitamin K decreased 20.29 10.45 6 154260 17 46531779
Sinus congestion 20.18 10.45 9 154257 13100 46518696
Immunodeficiency 20.17 10.45 9 154257 13097 46518699
Starvation ketoacidosis 20.15 10.45 8 154258 66 46531730
Diverticulum 20.11 10.45 6 154260 11200 46520596
Patient uncooperative 20.11 10.45 10 154256 147 46531649
Breast engorgement 20.09 10.45 9 154257 103 46531693
Dysphagia 20.03 10.45 363 153903 76949 46454847
Tubulointerstitial nephritis 20.02 10.45 12 154254 14776 46517020
Hypercalcaemia 20.02 10.45 24 154242 21022 46510774
Device related infection 20.01 10.45 24 154242 21017 46510779
Memory impairment 20.00 10.45 363 153903 76974 46454822
Urinary incontinence 20.00 10.45 162 154104 28368 46503428
Poverty of speech 19.92 10.45 12 154254 262 46531534
Aphasia 19.91 10.45 162 154104 28405 46503391
Bone density decreased 19.88 10.45 4 154262 9748 46522048
Pressure of speech 19.87 10.45 16 154250 564 46531232
Somatic symptom disorder of pregnancy 19.86 10.45 9 154257 106 46531690
Electrocardiogram T wave inversion 19.85 10.45 39 154227 3477 46528319
Stoma site discharge 19.69 10.45 28 154238 1912 46529884
Blood count abnormal 19.69 10.45 18 154248 17860 46513936
Rash maculo-papular 19.60 10.45 39 154227 27835 46503961
Post-traumatic stress disorder 19.44 10.45 42 154224 4006 46527790
Ileus 19.41 10.45 95 154171 13969 46517827
Contusion 19.38 10.45 190 154076 87297 46444499
Tuberculosis 19.35 10.45 5 154261 10260 46521536
Personality change due to a general medical condition 19.34 10.45 6 154260 21 46531775
Bipolar II disorder 19.33 10.45 12 154254 277 46531519
Increased appetite 19.22 10.45 67 154199 8460 46523336
Ventricular extrasystoles 19.22 10.45 80 154186 10983 46520813
Skin exfoliation 19.19 10.45 51 154215 32887 46498909
Eye irritation 19.18 10.45 16 154250 16598 46515198
Psychogenic tremor 19.13 10.45 6 154260 22 46531774
Protein C increased 19.08 10.45 10 154256 165 46531631
Sinus disorder 19.06 10.45 16 154250 16547 46515249
Slow speech 19.00 10.45 23 154243 1341 46530455
Antipsychotic drug level below therapeutic 18.99 10.45 12 154254 286 46531510
Anterior displaced anus 18.92 10.45 6 154260 23 46531773
Injection site warmth 18.89 10.45 11 154255 13761 46518035
Child abuse 18.86 10.45 4 154262 0 46531796
Uveitis 18.80 10.45 3 154263 8638 46523158
Duplicate therapy error 18.72 10.45 6 154260 24 46531772
Alcohol abuse 18.68 10.45 29 154237 2143 46529653
Morbid thoughts 18.67 10.45 15 154251 527 46531269
Ballismus 18.64 10.45 8 154258 82 46531714
Menstrual disorder 18.61 10.45 42 154224 4126 46527670
Cerebrovascular accident 18.57 10.45 229 154037 100810 46430986
Duodenal ulcer perforation 18.39 10.45 3 154263 8499 46523297
Hyperammonaemia 18.31 10.45 45 154221 4671 46527125
Perinatal depression 18.29 10.45 15 154251 543 46531253
Apraxia 18.23 10.45 25 154241 1650 46530146
Alcoholism 18.22 10.45 29 154237 2189 46529607
Chronic kidney disease 17.78 10.45 72 154194 40799 46490997
Pupil fixed 17.72 10.45 25 154241 1695 46530101
Skin reaction 17.68 10.45 7 154259 10939 46520857
Lactation disorder 17.64 10.45 11 154255 256 46531540
Parasomnia 17.61 10.45 13 154253 402 46531394
Transfusion 17.54 10.45 11 154255 13220 46518576
Screaming 17.54 10.45 35 154231 3156 46528640
Hospitalisation 17.47 10.45 130 154136 63255 46468541
Resuscitation 17.46 10.45 20 154246 1099 46530697
Incoherent 17.46 10.45 43 154223 4469 46527327
H1N1 influenza 17.45 10.45 23 154243 1461 46530335
Procedural pain 17.42 10.45 11 154255 13168 46518628
Gastric disorder 17.41 10.45 39 154227 26666 46505130
Lymphopenia 17.32 10.45 15 154251 15278 46516518
Epilepsy 17.30 10.45 136 154130 23602 46508194
Dermatitis 17.26 10.45 13 154253 14195 46517601
Psychotic symptom 17.22 10.45 18 154248 892 46530904
Faeces discoloured 17.22 10.45 18 154248 16769 46515027
Teratoma benign 17.20 10.45 7 154259 62 46531734
Intentional product use issue 17.18 10.45 103 154163 52677 46479119
Diabetic ketoacidosis 17.15 10.45 111 154155 18099 46513697
Decreased bronchial secretion 17.10 10.45 7 154259 63 46531733
Somatic delusion 17.06 10.45 15 154251 598 46531198
Delusional perception 17.03 10.45 10 154256 208 46531588
Atrioventricular block first degree 17.00 10.45 52 154214 6134 46525662
Lymphocyte count decreased 16.98 10.45 37 154229 25552 46506244
Feeling of body temperature change 16.96 10.45 41 154225 4211 46527585
Muscular weakness 16.93 10.45 208 154058 91636 46440160
Device difficult to use 16.92 10.45 3 154263 8001 46523795
Gastroenteritis viral 16.88 10.45 21 154245 18098 46513698
Staphylococcal infection 16.86 10.45 61 154205 35710 46496086
Pupillary light reflex tests abnormal 16.83 10.45 9 154257 155 46531641
Metastases to central nervous system 16.81 10.45 8 154258 11213 46520583
Product storage error 16.78 10.45 9 154257 11783 46520013
Indifference 16.76 10.45 8 154258 107 46531689
Hypocalcaemia 16.75 10.45 40 154226 26745 46505051
Peritonitis bacterial 16.73 10.45 4 154262 8649 46523147
Unevaluable event 16.72 10.45 87 154179 46088 46485708
Acute myocardial infarction 16.72 10.45 52 154214 31872 46499924
Schizoaffective disorder bipolar type 16.69 10.45 8 154258 108 46531688
Angioedema 16.68 10.45 70 154196 39272 46492524
Affective disorder 16.67 10.45 44 154222 4771 46527025
Fibromyalgia 16.65 10.45 63 154203 36400 46495396
Somatic hallucination 16.64 10.45 4 154262 3 46531793
Lung neoplasm malignant 16.58 10.45 16 154250 15473 46516323
Convulsive threshold lowered 16.57 10.45 12 154254 360 46531436
Pneumonitis 16.56 10.45 44 154222 28376 46503420
Osteopenia 16.50 10.45 19 154247 16942 46514854
Feelings of worthlessness 16.47 10.45 11 154255 289 46531507
Ulcer 16.36 10.45 20 154246 17372 46514424
Large for dates baby 16.35 10.45 13 154253 450 46531346
Binge eating 16.34 10.45 12 154254 368 46531428
Tenderness 16.32 10.45 19 154247 16862 46514934
Hallucination, olfactory 16.29 10.45 10 154256 226 46531570
Gait deviation 16.28 10.45 7 154259 72 46531724
Head titubation 16.28 10.45 15 154251 636 46531160
Lacrimation increased 16.27 10.45 17 154249 15844 46515952
Cytopenia 16.23 10.45 3 154263 7765 46524031
Sense of a foreshortened future 16.10 10.45 4 154262 4 46531792
Movement disorder 16.05 10.45 103 154163 16746 46515050
Ageusia 15.97 10.45 9 154257 11463 46520333
Angina pectoris 15.95 10.45 41 154225 26734 46505062
Pallor 15.94 10.45 131 154135 23035 46508761
Diabetes insipidus 15.93 10.45 27 154239 2147 46529649
Haematoma 15.93 10.45 53 154213 31819 46499977
Crying 15.89 10.45 122 154144 21019 46510777
Neonatal hypoxia 15.89 10.45 13 154253 469 46531327
Dysphonia 15.88 10.45 69 154197 38345 46493451
Echolalia 15.82 10.45 9 154257 176 46531620
Asphyxia 15.80 10.45 46 154220 5280 46526516
Pneumothorax 15.79 10.45 15 154251 14614 46517182
Nystagmus 15.75 10.45 48 154218 5651 46526145
Sudden cardiac death 15.74 10.45 27 154239 2168 46529628
Hyperinsulinaemia 15.71 10.45 7 154259 79 46531717
Proteinuria 15.61 10.45 19 154247 16534 46515262
Amimia 15.60 10.45 6 154260 45 46531751
Hyperhidrosis 15.60 10.45 396 153870 88912 46442884
Compulsive sexual behaviour 15.49 10.45 6 154260 46 46531750
Post procedural infection 15.49 10.45 3 154263 7510 46524286
Ileus paralytic 15.48 10.45 40 154226 4283 46527513
Abdominal pain lower 15.44 10.45 29 154237 21152 46510644
Cyanosis 15.44 10.45 98 154168 15873 46515923
Emotional disorder 15.43 10.45 81 154185 12243 46519553
Grandiosity 15.42 10.45 9 154257 185 46531611
Blunted affect 15.42 10.45 9 154257 185 46531611
Floppy infant 15.41 10.45 7 154259 83 46531713
Dysgeusia 15.40 10.45 75 154191 40416 46491380
Mental status changes 15.39 10.45 193 154073 37895 46493901
Soliloquy 15.38 10.45 9 154257 186 46531610
Agitation neonatal 15.36 10.45 13 154253 492 46531304
Apparent life threatening event 15.33 10.45 7 154259 84 46531712
Malignant polyp 15.33 10.45 9 154257 187 46531609
Labelled drug-drug interaction medication error 15.33 10.45 65 154201 8996 46522800
Dementia with Lewy bodies 15.30 10.45 10 154256 253 46531543
Gastroenteritis 15.28 10.45 36 154230 24183 46507613
Post procedural haemorrhage 15.24 10.45 3 154263 7423 46524373
Helicobacter infection 15.23 10.45 10 154256 11726 46520070
Pseudobulbar palsy 15.22 10.45 4 154262 6 46531790
Psychotic disorder due to a general medical condition 15.12 10.45 9 154257 192 46531604
Periorbital swelling 15.08 10.45 20 154246 1278 46530518
Acidosis 15.08 10.45 75 154191 11099 46520697
Confabulation 15.06 10.45 10 154256 260 46531536
Constipation 15.05 10.45 449 153817 173648 46358148
Bone marrow eosinophilic leukocyte count increased 15.04 10.45 5 154261 23 46531773
Hypoacusis 15.04 10.45 29 154237 20940 46510856
Gastric ulcer 15.02 10.45 31 154235 21832 46509964
Syncope 15.01 10.45 453 153813 104350 46427446
Rectal prolapse 14.97 10.45 22 154244 1548 46530248
Hypothyroidism 14.97 10.45 164 154102 31174 46500622
Pulmonary embolism 14.92 10.45 467 153799 108118 46423678
Post procedural complication 14.89 10.45 18 154248 15711 46516085
Compartment syndrome 14.88 10.45 25 154241 1974 46529822
Thrombotic thrombocytopenic purpura 14.85 10.45 37 154229 3873 46527923
Sciatica 14.81 10.45 25 154241 18995 46512801
Lymphoma 14.70 10.45 7 154259 9806 46521990
Incontinence 14.61 10.45 68 154198 9794 46522002
Spinal stenosis 14.58 10.45 12 154254 12531 46519265
Deafness 14.57 10.45 19 154247 16049 46515747
Bladder prolapse 14.52 10.45 24 154242 1870 46529926
Mitral valve incompetence 14.47 10.45 25 154241 18827 46512969
Pulmonary oedema 14.47 10.45 104 154162 51001 46480795
Personality disorder 14.47 10.45 32 154234 3101 46528695
Upper-airway cough syndrome 14.45 10.45 4 154262 7843 46523953
Aplastic anaemia 14.45 10.45 3 154263 7150 46524646
Idiopathic intracranial hypertension 14.37 10.45 28 154238 2481 46529315
Impaired self-care 14.36 10.45 23 154243 1745 46530051
Central nervous system injury 14.36 10.45 8 154258 150 46531646
Atelectasis 14.35 10.45 25 154241 18765 46513031
Antisocial behaviour 14.34 10.45 9 154257 212 46531584
Suspiciousness 14.31 10.45 11 154255 362 46531434
Breast enlargement 14.31 10.45 21 154245 1476 46530320
Gout 14.30 10.45 10 154256 11346 46520450
Progressive multifocal leukoencephalopathy 14.28 10.45 10 154256 11336 46520460
Vestibular migraine 14.25 10.45 7 154259 100 46531696
Genital labial adhesions 14.24 10.45 5 154261 28 46531768
Bradycardia foetal 14.23 10.45 11 154255 365 46531431
Pulseless electrical activity 14.20 10.45 54 154212 7113 46524683
Electroconvulsive therapy 14.19 10.45 6 154260 59 46531737
Dependence 14.18 10.45 24 154242 1907 46529889
Eye haemorrhage 14.15 10.45 3 154263 7049 46524747
Diabetic cardiomyopathy 14.15 10.45 3 154263 0 46531796
Buccoglossal syndrome 14.15 10.45 3 154263 0 46531796
Hypothermia neonatal 14.15 10.45 3 154263 0 46531796
Erotomanic delusion 14.15 10.45 3 154263 0 46531796
Separation anxiety disorder 14.15 10.45 3 154263 0 46531796
Exaggerated startle response 14.15 10.45 3 154263 0 46531796
Micrographia 14.15 10.45 3 154263 0 46531796
Breast discharge 14.15 10.45 16 154250 867 46530929
Encopresis 14.13 10.45 7 154259 102 46531694
Dissociative amnesia 14.09 10.45 5 154261 29 46531767
Allergic hepatitis 14.09 10.45 5 154261 29 46531767
Device pacing issue 14.09 10.45 5 154261 29 46531767
Infantile apnoea 14.06 10.45 15 154251 761 46531035
Bundle branch block 14.04 10.45 16 154250 874 46530922
Lack of spontaneous speech 14.03 10.45 8 154258 157 46531639
Migraine 13.91 10.45 156 154110 69870 46461926
Haematuria 13.88 10.45 44 154222 26814 46504982
Radial nerve palsy 13.85 10.45 11 154255 380 46531416
Tongue paralysis 13.83 10.45 9 154257 226 46531570
Bronchospasm 13.81 10.45 19 154247 15688 46516108
Haematotoxicity 13.81 10.45 3 154263 6930 46524866
Autonomic nervous system imbalance 13.81 10.45 27 154239 2399 46529397
Tricuspid valve incompetence 13.74 10.45 15 154251 13702 46518094
Fall 13.72 10.45 1264 153002 327833 46203963
Limbic encephalitis 13.66 10.45 9 154257 231 46531565
Anal sphincter atony 13.66 10.45 9 154257 231 46531565
Neurological examination abnormal 13.66 10.45 9 154257 231 46531565
Influenza like illness 13.61 10.45 123 154143 57447 46474349
Joint range of motion decreased 13.60 10.45 18 154248 15106 46516690
Insulin resistance 13.57 10.45 14 154252 683 46531113
Stoma site hypergranulation 13.55 10.45 12 154254 483 46531313
Ketoacidosis 13.55 10.45 36 154230 3919 46527877
Defect conduction intraventricular 13.55 10.45 7 154259 112 46531684
Tearfulness 13.52 10.45 37 154229 4098 46527698
Musculoskeletal disorder 13.47 10.45 19 154247 15526 46516270
Leukopenia neonatal 13.42 10.45 5 154261 34 46531762
Hiatus hernia 13.40 10.45 25 154241 18277 46513519
Dropped head syndrome 13.38 10.45 7 154259 115 46531681
Pulmonary fibrosis 13.38 10.45 29 154237 20063 46511733
Antipsychotic drug level above therapeutic 13.32 10.45 16 154250 925 46530871
Candida infection 13.29 10.45 34 154232 22206 46509590
Pre-eclampsia 13.26 10.45 57 154209 7937 46523859
Complication associated with device 13.26 10.45 19 154247 15422 46516374
Electrocardiogram change 13.19 10.45 13 154253 600 46531196
Patella fracture 13.14 10.45 23 154243 1877 46529919
Intervertebral disc protrusion 13.14 10.45 30 154236 20375 46511421
Hygroma colli 13.12 10.45 4 154262 13 46531783
Cellulitis orbital 13.09 10.45 11 154255 412 46531384
COVID-19 13.05 10.45 26 154240 18549 46513247
Spinal compression fracture 13.05 10.45 14 154252 12889 46518907
Pulse absent 13.01 10.45 41 154225 4915 46526881
Congestive cardiomyopathy 12.97 10.45 45 154221 5668 46526128
Sleep talking 12.97 10.45 16 154250 951 46530845
Colitis ischaemic 12.97 10.45 67 154199 10065 46521731
Metastases to lymph nodes 12.95 10.45 3 154263 6628 46525168
Amphetamines positive 12.93 10.45 6 154260 75 46531721
Dysmetropsia 12.93 10.45 6 154260 75 46531721
Pneumonia viral 12.93 10.45 3 154263 6621 46525175
Bacterial infection 12.92 10.45 21 154245 16195 46515601
Retrograde amnesia 12.91 10.45 10 154256 333 46531463
Muscle spasms 12.86 10.45 309 153957 122804 46408992
Asterixis 12.84 10.45 18 154248 1213 46530583
Diabetic complication 12.84 10.45 16 154250 961 46530835
Breast discomfort 12.83 10.45 10 154256 336 46531460
Brain hypoxia 12.83 10.45 12 154254 519 46531277
Tendonitis 12.83 10.45 17 154249 14260 46517536
Panic disorder 12.79 10.45 27 154239 2534 46529262
Flight of ideas 12.78 10.45 10 154256 338 46531458
Skin discolouration 12.73 10.45 60 154206 32620 46499176
Agitated depression 12.72 10.45 7 154259 128 46531668
Induced abortion failed 12.69 10.45 9 154257 261 46531535
Electroencephalogram abnormal 12.69 10.45 34 154232 3720 46528076
Bronchial aspiration procedure 12.68 10.45 8 154258 190 46531606
Blood creatinine increased 12.63 10.45 177 154089 76226 46455570
Tachypnoea 12.62 10.45 86 154180 14265 46517531
Infusion site pain 12.60 10.45 9 154257 10098 46521698
Irritable bowel syndrome 12.59 10.45 22 154244 16493 46515303
Oscillopsia 12.57 10.45 7 154259 131 46531665
Depression suicidal 12.56 10.45 20 154246 1510 46530286
Drowning 12.52 10.45 11 154255 438 46531358
Mass 12.52 10.45 12 154254 11641 46520155
Female sexual dysfunction 12.51 10.45 5 154261 42 46531754
Hypernatraemia 12.49 10.45 48 154218 6353 46525443
Facial spasm 12.49 10.45 13 154253 641 46531155
Angle closure glaucoma 12.41 10.45 24 154242 2115 46529681
Compulsions 12.39 10.45 8 154258 198 46531598
Libido increased 12.39 10.45 14 154252 758 46531038
Blood folate decreased 12.34 10.45 12 154254 545 46531251
Acinetobacter bacteraemia 12.26 10.45 6 154260 85 46531711
Acute generalised exanthematous pustulosis 12.22 10.45 8 154258 9397 46522399
Dry eye 12.21 10.45 55 154211 30267 46501529
Hangover 12.14 10.45 18 154248 1277 46530519
Hot flush 12.11 10.45 89 154177 43428 46488368
Splenic injury 12.08 10.45 8 154258 207 46531589
Congenital emphysema 12.08 10.45 3 154263 3 46531793
Withdrawal catatonia 12.03 10.45 5 154261 47 46531749
Spinal fracture 12.02 10.45 20 154246 15285 46516511
Abscess 12.01 10.45 17 154249 13872 46517924
Cardiac murmur 11.95 10.45 12 154254 11392 46520404
Cystitis 11.94 10.45 86 154180 42155 46489641
Blood calcium decreased 11.84 10.45 21 154245 15652 46516144
Abnormal dreams 11.81 10.45 66 154200 10213 46521583
Haemorrhage 11.80 10.45 120 154146 54749 46477047
Brain oedema 11.71 10.45 76 154190 12402 46519394
Exostosis 11.70 10.45 10 154256 10253 46521543
Wound 11.69 10.45 88 154178 42714 46489082
White blood cell count decreased 11.64 10.45 282 153984 111949 46419847
Spinal disorder 11.60 10.45 6 154260 8018 46523778
Reflexes abnormal 11.57 10.45 12 154254 589 46531207
Acute coronary syndrome 11.57 10.45 10 154256 10194 46521602
Somnolence neonatal 11.45 10.45 6 154260 99 46531697
Rebound psychosis 11.45 10.45 4 154262 22 46531774
Suicide threat 11.45 10.45 4 154262 22 46531774
Encephalopathy 11.42 10.45 165 154101 33424 46498372
Kidney duplex 11.42 10.45 5 154261 54 46531742
Pathological fracture 11.41 10.45 6 154260 7944 46523852
Delusional disorder, unspecified type 11.41 10.45 10 154256 397 46531399
Groin pain 11.39 10.45 8 154258 9057 46522739
Tooth abscess 11.39 10.45 15 154251 12618 46519178
Housebound 11.34 10.45 8 154258 230 46531566
Multiple sclerosis relapse 11.32 10.45 87 154179 42038 46489758
Carpal tunnel syndrome 11.31 10.45 22 154244 15837 46515959
Brugada syndrome 11.28 10.45 8 154258 232 46531564
Nail disorder 11.27 10.45 6 154260 7890 46523906
Blood iron decreased 11.27 10.45 12 154254 11085 46520711
Ovarian germ cell cancer stage II 11.26 10.45 5 154261 56 46531740
Haematochezia 11.25 10.45 75 154191 37418 46494378
Rotator cuff syndrome 11.24 10.45 13 154253 11570 46520226
Dyslipidaemia 11.19 10.45 42 154224 5498 46526298
Hemiparaesthesia 11.18 10.45 5 154261 57 46531739
Dysphoria 11.17 10.45 37 154229 4552 46527244
Drug diversion 11.15 10.45 14 154252 847 46530949
Blister 11.15 10.45 94 154172 44537 46487259
Antipsychotic drug level decreased 11.15 10.45 7 154259 165 46531631
Cerebral haemorrhage 11.11 10.45 52 154214 28319 46503477
Chemical burns of eye 11.10 10.45 5 154261 58 46531738
Tremor neonatal 11.09 10.45 6 154260 106 46531690
Device dislocation 11.07 10.45 36 154230 21766 46510030
Neurodegenerative disorder 11.06 10.45 9 154257 322 46531474
Ejection fraction decreased 11.04 10.45 27 154239 17910 46513886
Electrocardiogram ST segment elevation 11.04 10.45 32 154234 3663 46528133
Upper limb fracture 11.03 10.45 22 154244 15691 46516105
Diffuse large B-cell lymphoma 10.99 10.45 3 154263 5935 46525861
Faecal vomiting 10.96 10.45 12 154254 627 46531169
Obsessive thoughts 10.95 10.45 11 154255 520 46531276
Therapy cessation 10.91 10.45 48 154218 26581 46505215
Protrusion tongue 10.90 10.45 9 154257 329 46531467
Wound healing normal 10.87 10.45 3 154263 6 46531790
Macroprolactinaemia 10.87 10.45 3 154263 6 46531790
Atrophy of globe 10.87 10.45 3 154263 6 46531790
Ideas of reference 10.81 10.45 5 154261 62 46531734
Pyroglutamic acidosis 10.79 10.45 8 154258 249 46531547
Electrocardiogram ST segment depression 10.78 10.45 26 154240 2667 46529129
Blood osmolarity decreased 10.78 10.45 13 154253 755 46531041
Drug tolerance 10.73 10.45 29 154237 3189 46528607
Hypervigilance 10.67 10.45 9 154257 339 46531457
Tooth infection 10.66 10.45 15 154251 12271 46519525
Postoperative wound infection 10.64 10.45 8 154258 8745 46523051
Abulia 10.56 10.45 9 154257 344 46531452
Pseudomonas infection 10.54 10.45 10 154256 9748 46522048
Ultrasound abdomen abnormal 10.53 10.45 5 154261 66 46531730
Diet refusal 10.51 10.45 12 154254 657 46531139
Ovarian cancer 10.48 10.45 3 154263 5752 46526044
Hypoaldosteronism 10.47 10.45 7 154259 184 46531612
Cortisol increased 10.47 10.45 9 154257 348 46531448
Drug-device interaction 10.46 10.45 5 154261 67 46531729

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1499.77 11.65 1840 108907 97652 29744079
Neuroleptic malignant syndrome 1417.86 11.65 833 109914 15462 29826269
Toxicity to various agents 1238.17 11.65 2286 108461 174897 29666834
Suicide attempt 979.39 11.65 920 109827 35777 29805954
Sopor 890.90 11.65 537 110210 10454 29831277
Intentional overdose 749.08 11.65 843 109904 40638 29801093
Overdose 690.94 11.65 1169 109578 83168 29758563
Drug abuse 679.48 11.65 1143 109604 80929 29760802
Sedation 608.64 11.65 496 110251 15877 29825854
Drug interaction 593.96 11.65 1850 108897 197718 29644013
Psychotic disorder 588.19 11.65 547 110200 20968 29820763
Agitation 584.93 11.65 852 109895 53221 29788510
Aggression 518.00 11.65 660 110087 36247 29805484
Somnolence 509.38 11.65 1112 109635 95651 29746080
Extrapyramidal disorder 490.75 11.65 367 110380 10326 29831405
Tardive dyskinesia 477.92 11.65 273 110474 4784 29836947
Priapism 461.56 11.65 261 110486 4482 29837249
Intentional self-injury 436.91 11.65 378 110369 13154 29828577
Dystonia 415.78 11.65 320 110427 9407 29832324
Dyskinesia 409.69 11.65 453 110294 21381 29820350
Coma 396.63 11.65 609 110138 39840 29801891
Hallucination 390.53 11.65 672 110075 48387 29793344
Depression 359.34 11.65 932 109815 89505 29752226
Schizophrenia 355.02 11.65 283 110464 8765 29832966
Diarrhoea 349.21 11.65 435 110312 333668 29508063
Delusion 345.40 11.65 314 110433 11675 29830056
Depressed level of consciousness 305.97 11.65 525 110222 37697 29804034
Dyspnoea 303.28 11.65 479 110268 332816 29508915
Akathisia 296.50 11.65 214 110533 5690 29836041
Diabetes mellitus 293.95 11.65 543 110204 41322 29800409
Mania 292.00 11.65 254 110493 8900 29832831
Paranoia 291.84 11.65 266 110481 9922 29831809
Muscle rigidity 274.74 11.65 258 110489 10003 29831728
Suicidal ideation 266.94 11.65 479 110268 35635 29806096
Electrocardiogram QT prolonged 265.77 11.65 476 110271 35359 29806372
Catatonia 265.00 11.65 178 110569 4202 29837529
Febrile neutropenia 243.83 11.65 49 110698 106644 29735087
Hallucination, auditory 240.99 11.65 235 110512 9554 29832177
Restlessness 240.98 11.65 354 110393 22245 29819486
Delirium 236.50 11.65 487 110260 40144 29801587
Oculogyric crisis 233.32 11.65 110 110637 1265 29840466
Parkinsonism 218.44 11.65 195 110552 7074 29834657
Serotonin syndrome 215.43 11.65 297 110450 17594 29824137
Abnormal behaviour 198.50 11.65 347 110400 25276 29816455
Nausea 194.64 11.65 515 110232 296442 29545289
Intentional product misuse 191.77 11.65 407 110340 34260 29807471
Bradyphrenia 188.64 11.65 139 110608 3818 29837913
Blood creatine phosphokinase increased 185.39 11.65 463 110284 43385 29798346
Arthralgia 183.88 11.65 140 110607 135651 29706080
Pneumonia 183.82 11.65 629 110118 333677 29508054
Fatigue 181.31 11.65 596 110151 320077 29521654
Anaemia 177.43 11.65 311 110436 207681 29634050
Rash 170.00 11.65 280 110467 191609 29650122
Foetal exposure during pregnancy 165.05 11.65 398 110349 36473 29805258
Confusional state 162.01 11.65 950 109797 133884 29707847
Bipolar disorder 160.83 11.65 124 110623 3652 29838079
Drug withdrawal syndrome neonatal 156.94 11.65 114 110633 3061 29838670
Poisoning deliberate 155.25 11.65 147 110600 5757 29835974
Malignant neoplasm progression 153.45 11.65 39 110708 72248 29769483
Psychomotor hyperactivity 151.36 11.65 169 110578 8055 29833676
Poisoning 150.82 11.65 198 110549 11184 29830547
Tachycardia 149.57 11.65 604 110143 73135 29768596
Cardiac failure congestive 145.39 11.65 65 110682 84342 29757389
Disease progression 144.82 11.65 57 110690 79817 29761914
Obsessive-compulsive disorder 142.43 11.65 120 110627 4021 29837710
Atrial fibrillation 140.62 11.65 116 110631 108008 29733723
Weight increased 139.69 11.65 598 110149 74315 29767416
Type 2 diabetes mellitus 138.89 11.65 209 110538 13413 29828318
Tremor 137.00 11.65 597 110150 74766 29766965
Blood prolactin abnormal 134.15 11.65 62 110685 679 29841052
Rhabdomyolysis 132.28 11.65 525 110222 63055 29778676
Altered state of consciousness 130.55 11.65 251 110496 19668 29822063
Hyperprolactinaemia 127.55 11.65 70 110677 1130 29840601
Cough 125.06 11.65 169 110578 125473 29716258
Acute kidney injury 124.79 11.65 555 110192 273287 29568444
Anxiety 120.22 11.65 652 110095 89219 29752512
Respiratory disorder neonatal 117.25 11.65 66 110681 1122 29840609
Plasma cell myeloma 117.05 11.65 27 110720 53435 29788296
Euphoric mood 115.07 11.65 108 110639 4182 29837549
Diabetic coma 114.67 11.65 59 110688 830 29840901
Bradykinesia 113.98 11.65 95 110652 3135 29838596
Pain 113.85 11.65 298 110449 172343 29669388
Sepsis 113.17 11.65 232 110515 146163 29695568
Pruritus 112.64 11.65 164 110583 118040 29723691
Pyrexia 110.74 11.65 638 110109 293851 29547880
Hallucination, visual 109.24 11.65 206 110541 15907 29825824
Sexual dysfunction 108.18 11.65 122 110625 5879 29835852
Asthenia 107.79 11.65 437 110310 220853 29620878
Anosognosia 107.04 11.65 52 110695 642 29841089
Neuropathy peripheral 106.89 11.65 64 110683 70411 29771320
Emotional poverty 104.99 11.65 42 110705 312 29841419
Rheumatoid arthritis 104.99 11.65 14 110733 41183 29800548
Speech disorder 104.77 11.65 260 110487 24252 29817479
Hypomania 104.73 11.65 78 110669 2178 29839553
Disturbance in social behaviour 101.71 11.65 65 110682 1406 29840325
Bezoar 101.54 11.65 55 110692 864 29840867
Hyperkalaemia 101.45 11.65 59 110688 65951 29775780
Haemoglobin decreased 101.34 11.65 166 110581 113932 29727799
Social avoidant behaviour 100.60 11.65 84 110663 2779 29838952
Pleural effusion 99.33 11.65 77 110670 73989 29767742
Hyperreflexia 99.14 11.65 83 110664 2756 29838975
Interstitial lung disease 98.05 11.65 50 110697 60147 29781584
Headache 96.48 11.65 348 110399 181958 29659773
Restless legs syndrome 96.43 11.65 123 110624 6749 29834982
Metabolic syndrome 94.82 11.65 63 110684 1459 29840272
Joint swelling 94.59 11.65 28 110719 46918 29794813
Apathy 94.57 11.65 116 110631 6116 29835615
Irritability 93.82 11.65 240 110507 22810 29818921
Insomnia 92.25 11.65 626 110121 92710 29749021
Selective eating disorder 91.37 11.65 64 110683 1620 29840111
Platelet count decreased 90.92 11.65 158 110589 105971 29735760
Antipsychotic drug level below therapeutic 90.85 11.65 59 110688 1313 29840418
Cognitive disorder 90.62 11.65 241 110506 23449 29818282
Respiratory arrest 89.88 11.65 275 110472 28983 29812748
Back pain 89.48 11.65 151 110596 102445 29739286
Disinhibition 89.37 11.65 67 110680 1890 29839841
Decreased appetite 89.01 11.65 272 110475 149638 29692093
Thrombocytopenia 87.68 11.65 240 110507 136804 29704927
Myocardial infarction 87.28 11.65 211 110536 125414 29716317
Hypertonia neonatal 86.97 11.65 37 110710 327 29841404
Oedema peripheral 85.80 11.65 163 110584 105669 29736062
Pain in extremity 85.70 11.65 174 110573 110047 29731684
Gastrointestinal haemorrhage 85.26 11.65 110 110637 83336 29758395
Infusion related reaction 83.93 11.65 23 110724 40541 29801190
Infection 82.82 11.65 100 110647 77974 29763757
Drug hypersensitivity 81.26 11.65 80 110667 68439 29773292
Schizoaffective disorder 81.24 11.65 50 110697 1010 29840721
Psychiatric decompensation 80.88 11.65 54 110693 1261 29840470
Persecutory delusion 79.81 11.65 65 110682 2075 29839656
Urticaria 79.46 11.65 52 110695 54554 29787177
Pancytopenia 79.04 11.65 120 110627 84932 29756799
Sleep disorder 78.87 11.65 234 110513 24245 29817486
Drug withdrawal syndrome 78.29 11.65 204 110543 19605 29822126
Epistaxis 76.36 11.65 51 110696 52930 29788801
Mental disorder 75.60 11.65 159 110588 13290 29828441
Stomatitis 75.53 11.65 22 110725 37257 29804474
Obesity 74.35 11.65 122 110625 8433 29833298
Coronary artery disease 74.17 11.65 46 110701 49666 29792065
Anger 73.93 11.65 141 110606 10979 29830752
Cogwheel rigidity 73.14 11.65 48 110699 1088 29840643
Neonatal behavioural syndrome 73.02 11.65 24 110723 92 29841639
Withdrawal syndrome 72.77 11.65 141 110606 11109 29830622
Salivary hypersecretion 72.77 11.65 113 110634 7453 29834278
Mydriasis 72.45 11.65 101 110646 6042 29835689
Miosis 71.82 11.65 114 110633 7662 29834069
Drug screen positive 71.72 11.65 85 110662 4322 29837409
Sedation complication 70.78 11.65 42 110705 792 29840939
Dysphoria 69.29 11.65 60 110687 2088 29839643
Dysarthria 69.27 11.65 259 110488 30231 29811500
Hyperthermia 68.31 11.65 129 110618 9970 29831761
Neonatal respiratory distress syndrome 67.98 11.65 79 110668 3933 29837798
Metabolic disorder 67.81 11.65 75 110672 3536 29838195
Prescribed overdose 67.64 11.65 117 110630 8444 29833287
Visceral congestion 66.99 11.65 35 110712 509 29841222
Renal failure 66.95 11.65 248 110499 128718 29713013
Dementia 66.22 11.65 144 110603 12317 29829414
Homicidal ideation 66.04 11.65 62 110685 2401 29839330
Stupor 65.49 11.65 67 110680 2886 29838845
Suicidal behaviour 65.27 11.65 48 110699 1314 29840417
Agitation neonatal 65.24 11.65 43 110704 982 29840749
Acute myocardial infarction 64.88 11.65 60 110687 52879 29788852
Loss of consciousness 64.41 11.65 508 110239 78867 29762864
Disorientation 64.13 11.65 258 110489 31160 29810571
Psychomotor retardation 64.01 11.65 60 110687 2319 29839412
Prescription drug used without a prescription 63.94 11.65 46 110701 1216 29840515
Cardiac failure 62.86 11.65 134 110613 83284 29758447
Pneumonitis 61.83 11.65 13 110734 27441 29814290
Nasopharyngitis 61.74 11.65 76 110671 58773 29782958
Anaphylactic reaction 61.50 11.65 14 110733 27968 29813763
Ascites 61.28 11.65 28 110719 35893 29805838
Mental impairment 60.89 11.65 117 110630 9160 29832571
Logorrhoea 60.86 11.65 55 110692 2027 29839704
Cytomegalovirus infection 60.42 11.65 8 110739 23666 29818065
Mucosal inflammation 59.96 11.65 19 110728 30475 29811256
Seizure 59.60 11.65 591 110156 97884 29743847
Hypertriglyceridaemia 59.24 11.65 107 110640 7991 29833740
Blood prolactin increased 59.04 11.65 46 110701 1376 29840355
Herpes zoster 58.26 11.65 19 110728 29924 29811807
Blood triglycerides increased 58.12 11.65 147 110600 13870 29827861
Brugada syndrome 57.91 11.65 33 110714 575 29841156
Influenza 57.05 11.65 46 110701 43352 29798379
Bruxism 56.50 11.65 44 110703 1315 29840416
Drug dependence 56.17 11.65 190 110557 21105 29820626
Abdominal pain 55.69 11.65 285 110462 135369 29706362
Renal impairment 55.62 11.65 145 110602 84039 29757692
Increased appetite 55.57 11.65 85 110662 5532 29836199
Treatment noncompliance 55.28 11.65 212 110535 25041 29816690
Psychotic symptom 54.95 11.65 41 110706 1148 29840583
Sinus tachycardia 54.57 11.65 153 110594 15351 29826380
Malaise 54.18 11.65 378 110369 166584 29675147
Akinesia 54.13 11.65 56 110691 2444 29839287
Small for dates baby 54.07 11.65 63 110684 3145 29838586
Sinusitis 53.83 11.65 28 110719 33317 29808414
Chills 52.19 11.65 119 110628 72219 29769512
Poor quality sleep 52.11 11.65 95 110652 7146 29834585
Psychiatric symptom 51.43 11.65 63 110684 3316 29838415
Medication error 50.87 11.65 182 110565 20790 29820941
Oppositional defiant disorder 49.90 11.65 26 110721 376 29841355
Diabetic ketoacidosis 49.77 11.65 151 110596 15835 29825896
Torticollis 49.53 11.65 37 110710 1038 29840693
Hypotonia neonatal 48.71 11.65 36 110711 993 29840738
Wrong product administered 48.70 11.65 72 110675 4546 29837185
Faecaloma 48.37 11.65 70 110677 4335 29837396
Vomiting 48.29 11.65 550 110197 219268 29622463
Pneumocystis jirovecii pneumonia 48.27 11.65 4 110743 17116 29824615
Osteonecrosis of jaw 48.22 11.65 6 110741 18612 29823119
Hypokinesia 48.19 11.65 92 110655 7168 29834563
Thrombosis 48.13 11.65 51 110696 42180 29799551
Colitis 48.11 11.65 27 110720 30793 29810938
Sleep-related eating disorder 47.84 11.65 23 110724 277 29841454
Cerebrovascular accident 47.69 11.65 154 110593 83323 29758408
Antipsychotic drug level above therapeutic 47.46 11.65 36 110711 1034 29840697
Slow speech 47.43 11.65 35 110712 963 29840768
Cellulitis 47.42 11.65 62 110685 46722 29795009
Therapeutic product effect variable 47.25 11.65 40 110707 1349 29840382
Hyperkinesia 47.25 11.65 48 110699 2050 29839681
Erythema 47.00 11.65 139 110608 77312 29764419
Disturbance in attention 46.98 11.65 184 110563 21945 29819786
Unresponsive to stimuli 46.95 11.65 208 110539 26211 29815520
Chronic obstructive pulmonary disease 46.89 11.65 61 110686 46065 29795666
Blood creatinine increased 46.55 11.65 177 110570 91198 29750533
Loss of personal independence in daily activities 46.49 11.65 180 110567 21355 29820376
Dyspnoea exertional 46.01 11.65 38 110709 35392 29806339
Embolism venous 45.46 11.65 38 110709 1259 29840472
Thinking abnormal 45.16 11.65 75 110672 5236 29836495
Aspiration 45.16 11.65 112 110635 10439 29831292
Pneumonia aspiration 45.09 11.65 266 110481 37514 29804217
Myocarditis 44.69 11.65 108 110639 9903 29831828
Hypothermia 44.64 11.65 105 110642 9462 29832269
Cardio-respiratory arrest 44.41 11.65 363 110384 56943 29784788
Colitis ischaemic 44.31 11.65 78 110669 5708 29836023
Derealisation 44.28 11.65 27 110720 536 29841195
Temperature regulation disorder 44.01 11.65 26 110721 486 29841245
Depression suicidal 43.93 11.65 37 110710 1239 29840492
Coma scale abnormal 43.59 11.65 58 110689 3318 29838413
Myoclonus 43.58 11.65 128 110619 13184 29828547
Suspected suicide 43.44 11.65 56 110691 3105 29838626
Psoriasis 43.42 11.65 56 110691 42450 29799281
Vein of Galen aneurysmal malformation 43.06 11.65 11 110736 11 29841720
Oropharyngeal spasm 42.81 11.65 18 110729 154 29841577
Granulocytopenia 42.69 11.65 80 110667 6146 29835585
Tearfulness 42.46 11.65 40 110707 1556 29840175
Chest discomfort 42.38 11.65 64 110683 45416 29796315
Poverty of speech 42.36 11.65 19 110728 193 29841538
Pleurothotonus 42.27 11.65 33 110714 990 29840741
Sexually inappropriate behaviour 42.23 11.65 22 110725 318 29841413
Suspiciousness 42.20 11.65 23 110724 366 29841365
Basal cell carcinoma 42.05 11.65 5 110742 16063 29825668
Peripheral swelling 42.03 11.65 103 110644 60971 29780760
Diet refusal 41.93 11.65 22 110725 323 29841408
Neoplasm progression 41.70 11.65 8 110739 18015 29823716
Product substitution issue 41.35 11.65 105 110642 9930 29831801
Somnambulism 41.16 11.65 55 110692 3159 29838572
Upper gastrointestinal haemorrhage 41.09 11.65 15 110732 22013 29819718
On and off phenomenon 40.96 11.65 52 110695 2839 29838892
Posture abnormal 40.81 11.65 42 110705 1822 29839909
Chest pain 40.78 11.65 261 110486 117366 29724365
Oedema 40.55 11.65 60 110687 42933 29798798
Personality change 40.51 11.65 66 110681 4534 29837197
Weight decreased 40.41 11.65 360 110387 150561 29691170
Otospondylomegaepiphyseal dysplasia 40.33 11.65 16 110731 116 29841615
Large for dates baby 40.21 11.65 30 110717 840 29840891
Arthritis 40.11 11.65 20 110727 24381 29817350
Hepatic failure 40.05 11.65 40 110707 34003 29807728
Bone marrow failure 39.86 11.65 31 110716 29754 29811977
Stereotypy 39.85 11.65 25 110722 523 29841208
Decreased eye contact 39.80 11.65 23 110724 412 29841319
Depressed mood 39.79 11.65 146 110601 16883 29824848
Acute myeloid leukaemia 39.58 11.65 9 110738 17997 29823734
Judgement impaired 39.50 11.65 27 110720 656 29841075
Grimacing 39.21 11.65 20 110727 276 29841455
Haemorrhage 39.05 11.65 69 110678 46010 29795721
Arthropathy 38.85 11.65 14 110733 20713 29821018
Personality disorder 38.75 11.65 33 110714 1122 29840609
Hypersensitivity 38.06 11.65 90 110657 53938 29787793
Productive cough 37.82 11.65 33 110714 29920 29811811
Urinary incontinence 37.71 11.65 143 110604 16797 29824934
Gambling disorder 37.67 11.65 40 110707 1800 29839931
Asthma 37.63 11.65 47 110700 36127 29805604
Bipolar I disorder 37.62 11.65 28 110719 781 29840950
Dehydration 37.47 11.65 285 110462 123254 29718477
Antipsychotic drug level increased 37.25 11.65 52 110695 3114 29838617
Tachyphrenia 37.14 11.65 31 110716 1025 29840706
Blood pressure increased 36.83 11.65 139 110608 71789 29769942
Urinary retention 36.25 11.65 227 110520 32690 29809041
Electrocardiogram QT interval abnormal 36.16 11.65 13 110734 69 29841662
Incoherent 36.15 11.65 59 110688 4059 29837672
Brachial plexopathy 36.11 11.65 12 110735 48 29841683
Tic 36.09 11.65 41 110706 1991 29839740
Peritonitis 35.93 11.65 17 110730 21358 29820373
Lung disorder 35.86 11.65 38 110709 31431 29810300
Major depression 35.82 11.65 58 110689 3964 29837767
Psychomotor skills impaired 35.27 11.65 40 110707 1939 29839792
Septic shock 35.18 11.65 119 110628 63488 29778243
Drooling 34.83 11.65 49 110698 2956 29838775
Myelodysplastic syndrome 34.67 11.65 13 110734 18765 29822966
Hypoaesthesia 34.60 11.65 95 110652 54135 29787596
Hangover 34.54 11.65 30 110717 1048 29840683
Chronic kidney disease 34.53 11.65 54 110693 37784 29803947
Libido increased 34.38 11.65 27 110720 817 29840914
Muscle twitching 34.30 11.65 86 110661 8069 29833662
Full blood count decreased 34.26 11.65 8 110739 15709 29826022
Neonatal tachypnoea 34.22 11.65 14 110733 111 29841620
Depressive symptom 34.10 11.65 36 110711 1609 29840122
International normalised ratio increased 34.04 11.65 79 110668 47660 29794071
Delusional disorder, persecutory type 33.96 11.65 18 110729 270 29841461
Coordination abnormal 33.89 11.65 80 110667 7225 29834506
Dementia with Lewy bodies 33.72 11.65 23 110724 557 29841174
Multiple organ dysfunction syndrome 33.61 11.65 121 110626 63366 29778365
Palmar-plantar erythrodysaesthesia syndrome 33.56 11.65 7 110740 14863 29826868
Neonatal toxicity 33.33 11.65 10 110737 26 29841705
Abdominal discomfort 33.01 11.65 83 110664 48708 29793023
Flight of ideas 32.99 11.65 19 110728 338 29841393
Pulmonary fibrosis 32.88 11.65 9 110738 15881 29825850
Blood bilirubin increased 32.76 11.65 53 110694 36583 29805148
Device related infection 32.74 11.65 11 110736 17004 29824727
Haemoptysis 32.72 11.65 40 110707 31038 29810693
Trismus 32.66 11.65 42 110705 2323 29839408
Clonus 32.61 11.65 43 110704 2438 29839293
Dyslipidaemia 32.52 11.65 68 110679 5659 29836072
Hyperosmolar state 32.49 11.65 20 110727 404 29841327
Abulia 32.27 11.65 21 110726 469 29841262
Cholestasis 32.10 11.65 27 110720 24923 29816808
Flushing 32.08 11.65 37 110710 29455 29812276
Oral discharge 32.03 11.65 14 110733 133 29841598
Behaviour disorder 32.01 11.65 42 110705 2370 29839361
Acute psychosis 31.88 11.65 37 110710 1839 29839892
Accidental overdose 31.80 11.65 143 110604 18132 29823599
Atrial septal defect 31.76 11.65 74 110673 6627 29835104
Staring 31.53 11.65 33 110714 1460 29840271
Substance abuse 31.47 11.65 76 110671 6964 29834767
Tension 31.32 11.65 34 110713 1569 29840162
Blood cholesterol increased 31.21 11.65 135 110612 16835 29824896
Peritonitis bacterial 31.15 11.65 3 110744 11375 29830356
Screaming 30.98 11.65 31 110716 1300 29840431
Hyperammonaemic encephalopathy 30.72 11.65 36 110711 1808 29839923
Affective disorder 30.70 11.65 47 110700 3061 29838670
Diverticulitis 30.69 11.65 13 110734 17432 29824299
Inflammation 30.66 11.65 22 110725 22004 29819727
Psoriatic arthropathy 30.66 11.65 10 110737 15751 29825980
Sudden cardiac death 30.59 11.65 52 110695 3700 29838031
Death 30.50 11.65 1049 109698 356234 29485497
Galactorrhoea 30.45 11.65 18 110729 337 29841394
Swelling 30.36 11.65 54 110693 35921 29805810
Interleukin level increased 30.09 11.65 10 110737 40 29841691
Hypersomnia 29.86 11.65 101 110646 11215 29830516
Fluid retention 29.83 11.65 29 110718 24969 29816762
Hyperammonaemia 29.56 11.65 64 110683 5456 29836275
Prostate cancer 29.52 11.65 27 110720 23930 29817801
Bronchopulmonary aspergillosis 29.39 11.65 5 110742 12279 29829452
Loss of libido 29.36 11.65 37 110710 2005 29839726
Musculoskeletal pain 29.35 11.65 43 110704 30897 29810834
Freezing phenomenon 29.31 11.65 36 110711 1900 29839831
Respiratory depression 28.90 11.65 101 110646 11402 29830329
Impulsive behaviour 28.88 11.65 36 110711 1929 29839802
Skin ulcer 28.72 11.65 17 110730 18832 29822899
Type 1 diabetes mellitus 28.50 11.65 50 110697 3649 29838082
Psychosexual disorder 28.42 11.65 11 110736 74 29841657
Hypertonia 28.40 11.65 55 110692 4330 29837401
Lymphadenopathy 28.26 11.65 29 110718 24347 29817384
Pruritus genital 28.26 11.65 19 110728 449 29841282
Muscular weakness 28.23 11.65 130 110617 63515 29778216
Skin lesion 27.73 11.65 17 110730 18477 29823254
Hypocalcaemia 27.66 11.65 23 110724 21353 29820378
Reduced facial expression 27.64 11.65 23 110724 757 29840974
Rash maculo-papular 27.52 11.65 32 110715 25386 29816345
Haematuria 27.52 11.65 80 110667 44754 29796977
Blood urea increased 27.49 11.65 46 110701 31335 29810396
Stoma site erythema 27.46 11.65 26 110721 1018 29840713
Affect lability 27.38 11.65 47 110700 3371 29838360
Delusional disorder, unspecified type 27.28 11.65 23 110724 771 29840960
Gout 27.26 11.65 15 110732 17300 29824431
Blister 27.08 11.65 22 110725 20661 29821070
Distributive shock 27.04 11.65 21 110726 625 29841106
Subgaleal haematoma 26.88 11.65 8 110739 20 29841711
Enuresis 26.88 11.65 33 110714 1741 29839990
Illness anxiety disorder 26.87 11.65 13 110734 159 29841572
Electrocardiogram abnormal 26.76 11.65 64 110683 5828 29835903
Mood altered 26.69 11.65 79 110668 8171 29833560
Device dislocation 26.57 11.65 58 110689 4973 29836758
Pyromania 26.53 11.65 10 110737 62 29841669
Exposure via ingestion 26.52 11.65 40 110707 2571 29839160
Myoclonic epilepsy 26.49 11.65 23 110724 803 29840928
Prostatic specific antigen increased 26.38 11.65 6 110741 11998 29829733
Blepharospasm 26.16 11.65 24 110723 902 29840829
Leukopenia 26.10 11.65 320 110427 55839 29785892
Dyspepsia 26.07 11.65 45 110702 30284 29811447
Pancreatitis 26.06 11.65 227 110520 36263 29805468
Nonspecific reaction 26.04 11.65 28 110719 1278 29840453
Rash pruritic 26.00 11.65 27 110720 22545 29819186
Choreoathetosis 25.79 11.65 24 110723 919 29840812
Haemophagocytic lymphohistiocytosis 25.74 11.65 3 110744 9788 29831943
Dependence 25.72 11.65 27 110720 1199 29840532
Synovitis 25.71 11.65 3 110744 9780 29831951
Ketoacidosis 25.51 11.65 48 110699 3698 29838033
Angina unstable 25.42 11.65 7 110740 12303 29829428
Fluid overload 25.38 11.65 20 110727 19072 29822659
Bronchitis 25.36 11.65 68 110679 39057 29802674
Nightmare 25.30 11.65 100 110647 11976 29829755
Respiratory failure 25.21 11.65 244 110503 100398 29741333
Nephrolithiasis 25.01 11.65 33 110714 24777 29816954
Vasoplegia syndrome 24.91 11.65 27 110720 1244 29840487
Gastrointestinal disorder 24.88 11.65 41 110706 28096 29813635
Gastrointestinal necrosis 24.75 11.65 44 110703 3245 29838486
Wheezing 24.73 11.65 48 110699 30890 29810841
Myalgia 24.60 11.65 174 110573 76493 29765238
Dystonic tremor 24.59 11.65 11 110736 111 29841620
Impulse-control disorder 24.53 11.65 28 110719 1367 29840364
Neoplasm malignant 24.53 11.65 18 110729 17796 29823935
Stoma site discharge 24.51 11.65 29 110718 1472 29840259
Upper respiratory tract infection 24.33 11.65 40 110707 27436 29814295
Accidental death 24.24 11.65 34 110713 2045 29839686
Renal disorder 24.15 11.65 31 110716 23553 29818178
Newborn persistent pulmonary hypertension 24.15 11.65 10 110737 82 29841649
Encephalopathy neonatal 24.07 11.65 8 110739 32 29841699
Osteonecrosis 23.96 11.65 15 110732 16120 29825611
Urine alcohol test positive 23.88 11.65 8 110739 33 29841698
Illusion 23.86 11.65 21 110726 747 29840984
Transplant rejection 23.76 11.65 3 110744 9203 29832528
Lactic acidosis 23.61 11.65 50 110697 31163 29810568
Rebound effect 23.59 11.65 29 110718 1532 29840199
Alcoholism 23.57 11.65 44 110703 3370 29838361
Talipes 23.53 11.65 30 110717 1645 29840086
Pseudomonas infection 23.52 11.65 5 110742 10477 29831254
Overweight 23.42 11.65 28 110719 1437 29840294
Angina pectoris 23.42 11.65 46 110701 29472 29812259
Maternal drugs affecting foetus 23.41 11.65 50 110697 4223 29837508
Squamous cell carcinoma of skin 23.38 11.65 3 110744 9092 29832639
Unevaluable event 23.14 11.65 52 110695 31733 29809998
Autonomic nervous system imbalance 23.06 11.65 36 110711 2385 29839346
pH body fluid decreased 23.02 11.65 5 110742 0 29841731
Cerebral infarction 22.79 11.65 39 110708 26334 29815397
Cholecystitis 22.70 11.65 4 110743 9575 29832156
Hypomagnesaemia 22.56 11.65 17 110730 16581 29825150
Acute coronary syndrome 22.50 11.65 11 110736 13562 29828169
Penis injury 22.44 11.65 13 110734 234 29841497
Bacteraemia 22.38 11.65 15 110732 15545 29826186
Staphylococcal infection 22.37 11.65 49 110698 30175 29811556
Excessive eye blinking 22.24 11.65 13 110734 238 29841493
Incontinence 22.23 11.65 56 110691 5270 29836461
Feeling jittery 22.21 11.65 46 110701 3802 29837929
Oropharyngeal pain 22.10 11.65 45 110702 28451 29813280
Melaena 22.07 11.65 55 110692 32382 29809349
Tumour lysis syndrome 22.04 11.65 10 110737 12875 29828856
Excessive masturbation 22.00 11.65 10 110737 105 29841626
Refusal of treatment by patient 22.00 11.65 54 110693 4999 29836732
Compartment syndrome 21.91 11.65 36 110711 2491 29839240
Mood swings 21.86 11.65 70 110677 7556 29834175
Pyramidal tract syndrome 21.85 11.65 12 110735 194 29841537
Polydipsia 21.81 11.65 44 110703 3569 29838162
Slow response to stimuli 21.75 11.65 20 110727 754 29840977
Bone pain 21.64 11.65 23 110724 19003 29822728
Atrial flutter 21.59 11.65 13 110734 14268 29827463
Penile haemorrhage 21.57 11.65 18 110729 595 29841136
Abdominal pain upper 21.55 11.65 139 110608 62412 29779319
Troponin I increased 21.41 11.65 30 110717 1803 29839928
Necrotising colitis 21.38 11.65 22 110725 954 29840777
Angioedema 21.36 11.65 61 110686 34323 29807408
Immune reconstitution inflammatory syndrome 21.14 11.65 4 110743 9097 29832634
Congenital cerebrovascular anomaly 21.08 11.65 6 110741 12 29841719
Withdrawal arrhythmia 21.06 11.65 7 110740 28 29841703
Haematochezia 21.05 11.65 61 110686 34161 29807570
Neonatal seizure 20.96 11.65 16 110731 464 29841267
Pulmonary mass 20.94 11.65 7 110740 10855 29830876
Contraindication to medical treatment 20.81 11.65 16 110731 469 29841262
Anaphylactic shock 20.79 11.65 13 110734 13980 29827751
Drug diversion 20.71 11.65 21 110726 895 29840836
Brain hypoxia 20.71 11.65 14 110733 334 29841397
Impaired self-care 20.67 11.65 21 110726 897 29840834
Blunted affect 20.59 11.65 13 110734 275 29841456
Motor dysfunction 20.52 11.65 58 110689 5844 29835887
Coagulopathy 20.31 11.65 23 110724 18464 29823267
Resting tremor 20.29 11.65 17 110730 565 29841166
Renal injury 20.22 11.65 9 110738 11720 29830011
Psychotic behaviour 20.21 11.65 16 110731 490 29841241
Wrong patient received product 20.13 11.65 29 110718 1788 29839943
Localised infection 20.08 11.65 13 110734 13724 29828007
Hepatic encephalopathy 19.98 11.65 14 110733 14178 29827553
Osteoarthritis 19.97 11.65 23 110724 18326 29823405
Lung neoplasm malignant 19.93 11.65 16 110731 15116 29826615
Junctional ectopic tachycardia 19.89 11.65 6 110741 16 29841715
Hypoacusis 19.84 11.65 14 110733 14125 29827606
Verbal abuse 19.80 11.65 11 110736 182 29841549
Alcohol interaction 19.76 11.65 36 110711 2706 29839025
Sudden death 19.73 11.65 111 110636 15381 29826350
Fungal infection 19.71 11.65 13 110734 13587 29828144
Haemangioma congenital 19.66 11.65 16 110731 510 29841221
Hyperglycaemic hyperosmolar nonketotic syndrome 19.63 11.65 21 110726 953 29840778
Rectal haemorrhage 19.56 11.65 65 110682 34874 29806857
Stoma site inflammation 19.50 11.65 17 110730 597 29841134
Patient uncooperative 19.48 11.65 10 110737 140 29841591
Borderline personality disorder 19.43 11.65 14 110733 371 29841360
Ataxia 19.42 11.65 89 110658 11373 29830358
Injection site pain 19.40 11.65 53 110694 30257 29811474
IVth nerve disorder 19.37 11.65 6 110741 18 29841713
Cholelithiasis 19.28 11.65 28 110719 20197 29821534
Epidermolysis bullosa 19.28 11.65 9 110738 101 29841630
Flashback 19.23 11.65 10 110737 144 29841587
Perseveration 19.12 11.65 9 110738 103 29841628
Treatment failure 19.08 11.65 65 110682 34614 29807117
Orthostatic hypertension 19.04 11.65 11 110736 197 29841534
Renal tubular necrosis 19.01 11.65 17 110730 15234 29826497
Myoglobin blood increased 18.97 11.65 28 110719 1765 29839966
Waxy flexibility 18.90 11.65 9 110738 106 29841625
Acoustic stimulation tests abnormal 18.87 11.65 8 110739 70 29841661
Colon cancer 18.77 11.65 4 110743 8368 29833363
Generalised tonic-clonic seizure 18.60 11.65 130 110617 19421 29822310
Rhinorrhoea 18.57 11.65 30 110717 20724 29821007
Paraesthesia 18.57 11.65 121 110626 54206 29787525
Pulmonary hypertension 18.50 11.65 26 110721 19010 29822721
Haemorrhage intracranial 18.45 11.65 17 110730 15015 29826716
Oral pain 18.43 11.65 6 110741 9463 29832268
Carbon monoxide poisoning 18.39 11.65 9 110738 113 29841618
Polymerase chain reaction 18.30 11.65 8 110739 76 29841655
Self-injurious ideation 18.30 11.65 26 110721 1583 29840148
Troponin increased 18.27 11.65 73 110674 8784 29832947
Penoscrotal fusion 18.27 11.65 5 110742 8 29841723
Intentional product use issue 18.27 11.65 71 110676 36369 29805362
Inappropriate affect 18.25 11.65 16 110731 566 29841165
Diabetes insipidus 18.21 11.65 31 110716 2208 29839523
Water intoxication 18.20 11.65 15 110732 487 29841244
Intercepted medication error 18.15 11.65 15 110732 489 29841242
Kidney duplex 18.09 11.65 13 110734 343 29841388
Painful erection 18.05 11.65 11 110736 218 29841513
Clostridium difficile infection 18.04 11.65 19 110728 15764 29825967
Dizziness 18.04 11.65 566 110181 194343 29647388
Epilepsy 17.96 11.65 132 110615 20037 29821694
Eye movement disorder 17.91 11.65 43 110704 3925 29837806
Hyperglycaemia 17.86 11.65 204 110543 34996 29806735
End stage renal disease 17.85 11.65 3 110744 7432 29834299
Dysgraphia 17.80 11.65 25 110722 1506 29840225
Prescribed underdose 17.68 11.65 66 110681 7693 29834038
Patient isolation 17.68 11.65 6 110741 26 29841705
Vascular stenosis 17.66 11.65 10 110737 172 29841559
Apraxia 17.63 11.65 22 110725 1180 29840551
Parkinsonian rest tremor 17.53 11.65 9 110738 126 29841605
Convulsive threshold lowered 17.51 11.65 15 110732 514 29841217
Acute respiratory failure 17.46 11.65 44 110703 25806 29815925
Nervousness 17.43 11.65 88 110659 11700 29830031
Hepatotoxicity 17.42 11.65 25 110722 18120 29823611
Congestive cardiomyopathy 17.35 11.65 59 110688 6568 29835163
Communication disorder 17.29 11.65 30 110717 2170 29839561
Hepatitis cholestatic 17.17 11.65 4 110743 7868 29833863
Compulsions 17.16 11.65 10 110737 182 29841549
Injection site haemorrhage 17.12 11.65 4 110743 7851 29833880
Posturing 17.10 11.65 15 110732 531 29841200
Negativism 17.03 11.65 13 110734 377 29841354
Retrograde ejaculation 17.02 11.65 12 110735 307 29841424
Muscle hypertrophy 16.98 11.65 6 110741 30 29841701
Dry skin 16.95 11.65 36 110711 22418 29819313
Cholangitis 16.95 11.65 4 110743 7798 29833933
Brain injury 16.89 11.65 52 110695 5496 29836235
Distractibility 16.82 11.65 12 110735 313 29841418
Skin exfoliation 16.79 11.65 38 110709 23134 29818597
Mutism 16.71 11.65 17 110730 727 29841004
Panic attack 16.68 11.65 70 110677 8611 29833120
Purpura 16.64 11.65 8 110739 9959 29831772
Feelings of worthlessness 16.56 11.65 10 110737 195 29841536
Abdominal distension 16.55 11.65 100 110647 45609 29796122
Pulmonary haemorrhage 16.52 11.65 7 110740 9385 29832346
Erectile dysfunction 16.42 11.65 119 110628 17983 29823748
Osteomyelitis 16.42 11.65 18 110729 14663 29827068
Erection increased 16.41 11.65 15 110732 561 29841170
Muscle spasms 16.31 11.65 157 110590 64681 29777050
Delusional perception 16.31 11.65 9 110738 147 29841584
Immune thrombocytopenia 16.28 11.65 4 110743 7587 29834144
Drug dispensed to wrong patient 16.25 11.65 9 110738 148 29841583
Pulmonary arterial hypertension 16.25 11.65 7 110740 9294 29832437
Influenza like illness 16.21 11.65 45 110702 25560 29816171
Postmortem blood drug level 16.14 11.65 5 110742 15 29841716
Hypoxia 16.14 11.65 107 110640 47747 29793984
Alcohol abuse 16.13 11.65 50 110697 5303 29836428
Bundle branch block right 16.13 11.65 60 110687 6982 29834749
Congenital cystic kidney disease 16.05 11.65 12 110735 337 29841394
Sexual abuse 16.04 11.65 9 110738 152 29841579
Ill-defined disorder 16.02 11.65 79 110668 10405 29831326
Somatic symptom disorder 16.00 11.65 14 110733 494 29841237
Antisocial behaviour 16.00 11.65 11 110736 270 29841461
Multiple cardiac defects 15.97 11.65 7 110740 67 29841664
False positive investigation result 15.96 11.65 11 110736 271 29841460
Hepatitis 15.93 11.65 37 110710 22319 29819412
Gastrointestinal hypomotility 15.91 11.65 19 110728 974 29840757
Liver function test increased 15.88 11.65 11 110736 11205 29830526
Conduction disorder 15.85 11.65 27 110720 1924 29839807
Tooth disorder 15.84 11.65 7 110740 9154 29832577
Neonatal infection 15.82 11.65 11 110736 275 29841456
Colitis ulcerative 15.81 11.65 18 110729 14416 29827315
Proteinuria 15.74 11.65 22 110725 16123 29825608
Dysphonia 15.67 11.65 29 110718 19003 29822728
Hepatocellular carcinoma 15.61 11.65 8 110739 9602 29832129
Lymphoma 15.60 11.65 9 110738 10112 29831619
Eosinophilic pleural effusion 15.58 11.65 10 110737 218 29841513
Skin cancer 15.57 11.65 5 110742 7956 29833775
Hypoalbuminaemia 15.54 11.65 11 110736 11081 29830650
Myelocyte count increased 15.53 11.65 7 110740 72 29841659
Myocardial ischaemia 15.52 11.65 25 110722 17292 29824439
Hypercalcaemia 15.49 11.65 14 110733 12481 29829250
Oral candidiasis 15.48 11.65 11 110736 11060 29830671
Movement disorder 15.48 11.65 75 110672 9808 29831923
Mental status changes 15.41 11.65 207 110540 36872 29804859
Dysgeusia 15.40 11.65 44 110703 24757 29816974
Camptocormia 15.39 11.65 9 110738 165 29841566
Cerebral disorder 15.33 11.65 30 110717 2380 29839351
Inappropriate antidiuretic hormone secretion 15.32 11.65 83 110664 11339 29830392
Tongue spasm 15.30 11.65 6 110741 42 29841689
Enteritis 15.26 11.65 3 110744 6642 29835089
Feeling guilty 15.22 11.65 11 110736 293 29841438
Substance use 15.19 11.65 13 110734 445 29841286
Homicide 15.11 11.65 19 110728 1027 29840704
Cytokine release syndrome 15.07 11.65 9 110738 9924 29831807
Dependent personality disorder 15.06 11.65 6 110741 44 29841687
Ventricular tachycardia 15.06 11.65 42 110705 23820 29817911
Patent ductus arteriosus 15.02 11.65 35 110712 3134 29838597
Gynaecomastia 15.02 11.65 66 110681 8285 29833446
Blood urine present 14.98 11.65 9 110738 9891 29831840
Tubulointerstitial nephritis 14.96 11.65 27 110720 17864 29823867
Optic discs blurred 14.96 11.65 7 110740 79 29841652
Hepatic cancer 14.95 11.65 3 110744 6545 29835186
Stoma site infection 14.91 11.65 18 110729 933 29840798
Yawning 14.89 11.65 14 110733 543 29841188
Binge eating 14.88 11.65 7 110740 80 29841651
Laboratory test abnormal 14.88 11.65 26 110721 17416 29824315
Parkinsonian gait 14.88 11.65 13 110734 458 29841273
Somatic delusion 14.86 11.65 8 110739 124 29841607
Multiple drug therapy 14.85 11.65 10 110737 237 29841494
Lower respiratory tract infection 14.74 11.65 50 110697 26664 29815067
Crying 14.74 11.65 50 110697 5559 29836172
Choking 14.72 11.65 46 110701 4900 29836831
Amnesia 14.70 11.65 146 110601 24175 29817556
Antisocial personality disorder 14.67 11.65 5 110742 22 29841709
Breast inflammation 14.67 11.65 5 110742 22 29841709
Faeces discoloured 14.63 11.65 18 110729 13928 29827803
Anamnestic reaction 14.62 11.65 6 110741 48 29841683
Squamous cell carcinoma 14.58 11.65 10 110737 10240 29831491
Discomfort 14.57 11.65 19 110728 14337 29827394
Anomaly of external ear congenital 14.48 11.65 8 110739 131 29841600
Hernia 14.46 11.65 7 110740 8679 29833052
Postmortem blood drug level increased 14.42 11.65 8 110739 132 29841599
Divorced 14.40 11.65 4 110743 7 29841724
Swelling face 14.39 11.65 36 110711 21168 29820563
Injection site erythema 14.36 11.65 18 110729 13816 29827915
Metastases to bone 14.31 11.65 9 110738 9649 29832082
Selective mutism 14.30 11.65 6 110741 51 29841680
Hypertension 14.16 11.65 341 110406 121013 29720718
Delusion of reference 14.15 11.65 5 110742 25 29841706
Diastolic hypotension 14.15 11.65 5 110742 25 29841706
Alcohol use 14.15 11.65 38 110709 3717 29838014
Neurological symptom 14.13 11.65 36 110711 3411 29838320
Sluggishness 14.12 11.65 34 110713 3109 29838622
Xanthoma 14.09 11.65 7 110740 91 29841640
Toxic skin eruption 14.07 11.65 12 110735 11003 29830728
Stoma site hypergranulation 14.06 11.65 11 110736 331 29841400
Hyperhidrosis 14.05 11.65 336 110411 66754 29774977
Loss of employment 14.05 11.65 13 110734 494 29841237
Intermittent explosive disorder 14.05 11.65 4 110743 8 29841723
Phaeochromocytoma malignant 14.01 11.65 6 110741 54 29841677
Jealous delusion 13.94 11.65 10 110737 263 29841468
Clostridium difficile colitis 13.90 11.65 16 110731 12752 29828979
Foaming at mouth 13.89 11.65 15 110732 688 29841043
Facial spasm 13.87 11.65 9 110738 200 29841531
Neuralgia 13.86 11.65 11 110736 10455 29831276
Neuroleptic-induced deficit syndrome 13.84 11.65 5 110742 27 29841704
Cyanosis neonatal 13.81 11.65 10 110737 267 29841464
Drug resistance 13.80 11.65 34 110713 20099 29821632
Lymphopenia 13.79 11.65 17 110730 13146 29828585
Drug level decreased 13.75 11.65 50 110697 5755 29835976
Ageusia 13.74 11.65 8 110739 8945 29832786
Drug withdrawal headache 13.73 11.65 4 110743 9 29841722
Helplessness 13.73 11.65 6 110741 57 29841674
Metastases to lung 13.70 11.65 6 110741 7889 29833842
Total cholesterol/HDL ratio increased 13.62 11.65 8 110739 148 29841583
Anticholinergic syndrome 13.58 11.65 16 110731 808 29840923
Pressure of speech 13.56 11.65 12 110735 430 29841301
Shock haemorrhagic 13.54 11.65 10 110737 9855 29831876
Drug level increased 13.53 11.65 115 110632 18239 29823492
Impaired healing 13.53 11.65 20 110727 14320 29827411
Acute generalised exanthematous pustulosis 13.50 11.65 3 110744 6095 29835636
Pain in jaw 13.49 11.65 15 110732 12141 29829590
Fall 13.47 11.65 811 109936 181061 29660670
Hepatitis B 13.41 11.65 3 110744 6069 29835662
Delirium febrile 13.40 11.65 5 110742 30 29841701
Arachnoid cyst 13.37 11.65 9 110738 213 29841518
Blood pressure systolic increased 13.37 11.65 22 110725 15088 29826643
Delusion of grandeur 13.35 11.65 11 110736 357 29841374
Toxic epidermal necrolysis 13.34 11.65 29 110718 17911 29823820
Drug reaction with eosinophilia and systemic symptoms 13.34 11.65 57 110690 28431 29813300
Learning disability 13.29 11.65 8 110739 155 29841576
Electroencephalogram abnormal 13.26 11.65 28 110719 2346 29839385
Coronary artery occlusion 13.24 11.65 13 110734 11144 29830587
Hypophosphataemia 13.19 11.65 7 110740 8238 29833493
Visual acuity reduced 13.18 11.65 24 110723 15822 29825909
Dysphagia 13.13 11.65 288 110459 56410 29785321
Pulmonary alveolar haemorrhage 13.11 11.65 4 110743 6577 29835154
Flat affect 13.02 11.65 16 110731 845 29840886
Respiratory fatigue 12.96 11.65 6 110741 66 29841665
Cleft lip and palate 12.92 11.65 10 110737 296 29841435
Ischaemic enteritis 12.92 11.65 4 110743 12 29841719
Caesarean section 12.87 11.65 26 110721 2111 29839620
Memory impairment 12.86 11.65 201 110546 36973 29804758
Abscess 12.85 11.65 11 110736 10067 29831664
Postoperative respiratory failure 12.80 11.65 6 110741 68 29841663
Lip swelling 12.79 11.65 17 110730 12727 29829004
Sexual activity increased 12.75 11.65 5 110742 35 29841696
Shock 12.75 11.65 135 110612 22724 29819007
Self-medication 12.75 11.65 27 110720 2267 29839464
Cardiac failure chronic 12.75 11.65 3 110744 5860 29835871
Retrognathia 12.74 11.65 9 110738 231 29841500
Initial insomnia 12.72 11.65 29 110718 2560 29839171
Metabolic encephalopathy 12.67 11.65 37 110710 3798 29837933
Apgar score low 12.67 11.65 16 110731 869 29840862
Device kink 12.67 11.65 13 110734 562 29841169
Malignant catatonia 12.65 11.65 7 110740 115 29841616
Condition aggravated 12.62 11.65 627 110120 137239 29704492
Iron deficiency anaemia 12.58 11.65 9 110738 9015 29832716
Stevens-Johnson syndrome 12.55 11.65 29 110718 17527 29824204
Product storage error 12.53 11.65 4 110743 6387 29835344
Blood creatine phosphokinase decreased 12.52 11.65 12 110735 477 29841254
Transfusion 12.44 11.65 6 110741 7455 29834276
Hot flush 12.42 11.65 22 110725 14658 29827073
Eye swelling 12.41 11.65 9 110738 8955 29832776
Blood alkaline phosphatase increased 12.41 11.65 67 110680 31420 29810311
Sciatic nerve neuropathy 12.36 11.65 6 110741 74 29841657
Neuromuscular toxicity 12.29 11.65 5 110742 39 29841692
Metamyelocyte count increased 12.28 11.65 6 110741 75 29841656
Hyperdynamic left ventricle 12.28 11.65 6 110741 75 29841656
Volvulus 12.24 11.65 19 110728 1252 29840479
Post procedural haemorrhage 12.24 11.65 7 110740 7903 29833828
Frequent bowel movements 12.22 11.65 8 110739 8397 29833334
Pancreatitis haemorrhagic 12.20 11.65 10 110737 322 29841409
Congenital pulmonary valve atresia 12.15 11.65 6 110741 77 29841654
Urine leukocyte esterase positive 12.10 11.65 10 110737 326 29841405
Congenital ureteric anomaly 12.04 11.65 4 110743 16 29841715
Pancreatic carcinoma 12.04 11.65 7 110740 7830 29833901
Heart rate abnormal 12.02 11.65 21 110726 1527 29840204
Knee arthroplasty 12.01 11.65 3 110744 5627 29836104
Attention deficit hyperactivity disorder 11.96 11.65 23 110724 1801 29839930
Panic disorder 11.93 11.65 18 110729 1157 29840574
Injection site pruritus 11.89 11.65 3 110744 5589 29836142
Congenital mitral valve incompetence 11.88 11.65 6 110741 81 29841650
Large intestine polyp 11.80 11.65 5 110742 6704 29835027
Epstein-Barr virus infection 11.79 11.65 5 110742 6701 29835030
Generalised oedema 11.78 11.65 16 110731 11869 29829862
Haemolysis 11.77 11.65 6 110741 7225 29834506
Depersonalisation/derealisation disorder 11.76 11.65 12 110735 515 29841216
Enterocolitis 11.74 11.65 5 110742 6682 29835049
Pulmonary oedema 11.69 11.65 105 110642 43870 29797861
Epileptic psychosis 11.66 11.65 4 110743 18 29841713

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37887 adrenergic receptor blockaders
CHEBI has role CHEBI:37956 histamine receptor blocker
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:65191 atypical antipsychotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Transporter Transporter Ki 6.17 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0701357 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL3188993 ChEMBL_ID
CHEMBL716 ChEMBL_ID
CHEMBL1200911 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
DB01224 DRUGBANK_ID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
5281025 PUBCHEM_CID
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 33 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 33 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0280 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0281 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0282 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0283 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 33 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0284 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1180 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1181 TABLET, EXTENDED RELEASE 150 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1182 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1183 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 33 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1184 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 33 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7724 TABLET, FILM COATED 50 mg ORAL ANDA 33 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0615-7725 TABLET, FILM COATED 100 mg ORAL ANDA 33 sections