quetiapine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2337 111974-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quetiapine
  • quetiapine fumarate
  • quetiapine hemifumarate
  • ICI 204,636
  • seroquel
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
  • Molecular weight: 383.51
  • Formula: C21H25N3O2S
  • CLOGP: 2.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 48.30
  • ALOGS: -3.98
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 94 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.68 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 9 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1997 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3473.87 10.22 3235 178592 128654 50294643
Toxicity to various agents 3069.60 10.22 3789 178038 208710 50214587
Intentional overdose 2460.61 10.22 1933 179894 60571 50362726
Sopor 2420.27 10.22 1256 180571 18623 50404674
Suicide attempt 2277.07 10.22 1710 180117 50022 50373275
Drug abuse 2157.43 10.22 1758 180069 58088 50365209
Overdose 1382.69 10.22 1746 180081 97981 50325316
Neuroleptic malignant syndrome 1364.99 10.22 707 181120 10423 50412874
Intentional self-injury 1346.36 10.22 907 180920 22205 50401092
Drug interaction 1113.65 10.22 2308 179519 197313 50225984
Sedation 1014.04 10.22 857 180970 29753 50393544
Electrocardiogram QT prolonged 949.94 10.22 1048 180779 50838 50372459
Somnolence 920.57 10.22 1840 179987 153145 50270152
Coma 842.16 10.22 1030 180797 55849 50367448
Dystonia 841.50 10.22 528 181299 11398 50411899
Tardive dyskinesia 828.65 10.22 440 181387 6839 50416458
Suicidal ideation 681.35 10.22 915 180912 54470 50368827
Akathisia 640.76 10.22 388 181439 7841 50415456
Dyskinesia 626.08 10.22 628 181199 27233 50396064
Gestational diabetes 620.26 10.22 367 181460 7098 50416199
Depressed level of consciousness 615.79 10.22 843 180984 51110 50372187
Agitation 590.60 10.22 838 180989 52546 50370751
Extrapyramidal disorder 534.67 10.22 397 181430 11373 50411924
Mania 517.96 10.22 378 181449 10538 50412759
Diabetes mellitus 471.99 10.22 721 181106 48312 50374985
Blood prolactin abnormal 449.90 10.22 198 181629 1977 50421320
Arthralgia 447.99 10.22 552 181275 438150 49985147
Sexual dysfunction 435.04 10.22 220 181607 3072 50420225
Serotonin syndrome 432.78 10.22 488 181339 24225 50399072
Tachycardia 431.80 10.22 1044 180783 98719 50324578
Parkinsonism 423.47 10.22 308 181519 8539 50414758
Poisoning 409.36 10.22 347 181480 12082 50411215
Muscle rigidity 405.45 10.22 313 181514 9516 50413781
Schizophrenia 385.02 10.22 271 181556 7126 50416171
Pain 384.36 10.22 956 180871 577947 49845350
Diarrhoea 380.53 10.22 985 180842 587491 49835806
Joint swelling 377.15 10.22 206 181621 245080 50178217
Anosognosia 369.37 10.22 174 181653 2060 50421237
Cardio-respiratory arrest 359.67 10.22 673 181154 53219 50370078
Delusion 356.15 10.22 299 181528 10270 50413027
Disturbance in social behaviour 338.02 10.22 178 181649 2716 50420581
Hallucination, auditory 335.97 10.22 291 181536 10437 50412860
Psychotic disorder 335.56 10.22 403 181424 21409 50401888
Hallucination 324.32 10.22 593 181234 46064 50377233
Altered state of consciousness 322.73 10.22 396 181431 21514 50401783
Rash 315.09 10.22 691 181136 436780 49986517
Aggression 308.36 10.22 380 181447 20736 50402561
Dyspnoea 298.18 10.22 993 180834 546615 49876682
Restlessness 294.36 10.22 406 181421 24767 50398530
Respiratory arrest 291.12 10.22 443 181384 29566 50393731
Metabolic disorder 285.23 10.22 198 181629 5088 50418209
Bradyphrenia 284.98 10.22 210 181617 5942 50417355
Tremor 274.87 10.22 973 180854 113930 50309367
Fatigue 272.51 10.22 1466 180361 706135 49717162
Delirium 267.41 10.22 487 181340 37705 50385592
Poisoning deliberate 266.93 10.22 224 181603 7688 50415609
Cardiac arrest 263.12 10.22 778 181049 82873 50340424
Hypomania 262.64 10.22 177 181650 4328 50418969
Bezoar 260.47 10.22 117 181710 1231 50422066
Personality change 259.93 10.22 192 181635 5453 50417844
Peripheral swelling 257.51 10.22 217 181610 205719 50217578
Abnormal behaviour 257.30 10.22 335 181492 19323 50403974
Exposure during pregnancy 255.29 10.22 984 180843 120031 50303266
Seizure 254.02 10.22 965 180862 116909 50306388
Sinusitis 253.71 10.22 149 181678 170409 50252888
Nasopharyngitis 245.27 10.22 200 181627 192727 50230570
Loss of consciousness 243.00 10.22 876 180951 103477 50319820
Confusional state 238.67 10.22 1306 180521 184622 50238675
Pain in extremity 236.52 10.22 385 181442 272480 50150817
Mydriasis 233.97 10.22 237 181590 10390 50412907
Bradykinesia 227.67 10.22 154 181673 3789 50419508
Drug intolerance 224.79 10.22 274 181553 218830 50204467
Intentional product misuse 223.71 10.22 509 181318 46225 50377072
Psychomotor hyperactivity 222.47 10.22 217 181610 9084 50414213
Galactorrhoea 221.17 10.22 148 181679 3575 50419722
Drug hypersensitivity 216.72 10.22 355 181472 250655 50172642
Hypersensitivity 214.53 10.22 275 181552 214886 50208411
Swelling 212.67 10.22 245 181582 200627 50222670
Pruritus 211.19 10.22 439 181388 283129 50140168
Sinus tachycardia 203.95 10.22 313 181514 21041 50402256
Synovitis 203.68 10.22 95 181732 123770 50299527
Cough 202.00 10.22 348 181479 240916 50182381
Infection 199.77 10.22 196 181631 172758 50250539
Infusion related reaction 196.01 10.22 192 181635 169365 50253932
Febrile neutropenia 192.39 10.22 56 181771 97611 50325686
Anticholinergic syndrome 191.64 10.22 104 181723 1691 50421606
Hyperprolactinaemia 190.89 10.22 130 181697 3235 50420062
Disorientation 189.65 10.22 404 181423 35080 50388217
Metabolic syndrome 186.74 10.22 93 181734 1254 50422043
Stubbornness 185.27 10.22 60 181767 225 50423072
Abdominal discomfort 182.37 10.22 347 181480 231294 50192003
Bipolar disorder 181.31 10.22 168 181659 6589 50416708
Hallucinations, mixed 180.97 10.22 136 181691 3967 50419330
Restless legs syndrome 179.27 10.22 252 181575 15645 50407652
Alopecia 177.67 10.22 385 181442 244662 50178635
Rheumatoid arthritis 177.07 10.22 284 181543 202266 50221031
Urinary retention 177.06 10.22 329 181498 25861 50397436
Headache 175.80 10.22 1084 180743 505451 49917846
Nausea 175.45 10.22 1657 180170 703741 49719556
Disturbance in attention 171.22 10.22 359 181468 30827 50392470
Back pain 166.79 10.22 337 181490 219693 50203604
Malignant neoplasm progression 165.17 10.22 24 181803 68100 50355197
Disease progression 163.12 10.22 70 181757 95796 50327501
Speech disorder 162.21 10.22 380 181447 35168 50388129
Anxiety 161.45 10.22 1142 180685 176464 50246833
Suspected suicide 161.07 10.22 142 181685 5215 50418082
Diabetic coma 158.83 10.22 68 181759 631 50422666
Paranoia 157.18 10.22 190 181637 10158 50413139
Drug ineffective 153.88 10.22 2051 179776 817282 49606015
Dysarthria 153.72 10.22 384 181443 37019 50386278
Labour complication 153.59 10.22 41 181786 59 50423238
Pneumonia 152.78 10.22 770 181057 377631 50045666
Treatment failure 152.05 10.22 162 181665 137475 50285822
Hypotension 149.98 10.22 1396 180431 234073 50189224
Respiratory depression 148.40 10.22 199 181628 11811 50411486
Blood prolactin increased 146.27 10.22 107 181720 2992 50420305
Oculogyric crisis 144.42 10.22 80 181747 1357 50421940
Liver injury 142.56 10.22 291 181536 24515 50398782
Stomatitis 140.35 10.22 96 181731 101248 50322049
Cogwheel rigidity 138.86 10.22 84 181743 1693 50421604
Depersonalisation/derealisation disorder 135.14 10.22 72 181755 1126 50422171
Hyperammonaemic encephalopathy 132.23 10.22 85 181742 1914 50421383
Irritability 130.92 10.22 305 181522 28121 50395176
Withdrawal syndrome 130.38 10.22 230 181597 17360 50405937
Anaemia 128.59 10.22 470 181357 251986 50171311
Electrocardiogram QRS complex prolonged 128.40 10.22 125 181702 5219 50418078
Substance abuse 127.36 10.22 111 181716 4013 50419284
Catatonia 126.49 10.22 106 181721 3630 50419667
Herpes zoster 124.76 10.22 49 181778 70737 50352560
Urticaria 124.51 10.22 170 181657 129391 50293906
Derealisation 124.05 10.22 65 181762 981 50422316
Blood creatine phosphokinase increased 123.73 10.22 285 181542 26082 50397215
Coma scale abnormal 122.97 10.22 116 181711 4655 50418642
Lower respiratory tract infection 121.72 10.22 98 181729 95103 50328194
Obesity 120.04 10.22 216 181611 16559 50406738
Therapeutic product effect decreased 119.53 10.22 190 181637 135860 50287437
Thinking abnormal 118.94 10.22 159 181668 9408 50413889
Pleurothotonus 118.75 10.22 68 181759 1233 50422064
Injection site erythema 117.80 10.22 61 181766 74875 50348422
Antipsychotic drug level increased 117.41 10.22 94 181733 3015 50420282
Arthropathy 116.08 10.22 246 181581 157660 50265637
Impaired healing 115.48 10.22 53 181774 69733 50353564
Drug withdrawal syndrome 115.38 10.22 269 181558 24812 50398485
Unresponsive to stimuli 114.15 10.22 303 181524 30306 50392991
Contraindicated product administered 111.22 10.22 230 181597 148728 50274569
Systemic lupus erythematosus 109.38 10.22 212 181615 140410 50282887
Gastrointestinal disorder 109.02 10.22 107 181720 94349 50328948
Neuropathy peripheral 108.94 10.22 112 181715 96645 50326652
Treatment noncompliance 107.95 10.22 294 181533 29856 50393441
Miosis 107.70 10.22 123 181704 6187 50417110
Weight increased 107.67 10.22 1154 180673 200737 50222560
Arthritis 107.49 10.22 92 181735 86629 50336668
Feeling of despair 107.49 10.22 75 181752 1943 50421354
Orthostatic hypertension 106.93 10.22 43 181784 335 50422962
Cardiac failure congestive 106.46 10.22 88 181739 84294 50339003
Type 2 diabetes mellitus 106.35 10.22 318 181509 34057 50389240
Obsessive-compulsive disorder 105.37 10.22 91 181736 3249 50420048
Erythema 105.20 10.22 231 181596 146183 50277114
Hand deformity 105.08 10.22 123 181704 100076 50323221
Depression 104.83 10.22 980 180847 164443 50258854
Hallucination, visual 104.27 10.22 202 181625 16380 50406917
Mood swings 103.57 10.22 197 181630 15757 50407540
Persecutory delusion 102.79 10.22 78 181749 2309 50420988
Sepsis 101.13 10.22 203 181624 132722 50290575
Hypokinesia 100.08 10.22 167 181660 12050 50411247
Malaise 98.28 10.22 754 181073 334778 50088519
Rhabdomyolysis 97.07 10.22 335 181492 38692 50384605
Salivary hypersecretion 96.82 10.22 119 181708 6472 50416825
Disorganised speech 96.40 10.22 54 181773 937 50422360
Somnambulism 96.16 10.22 103 181724 4821 50418476
Pneumonia aspiration 96.09 10.22 287 181540 30717 50392580
Mucosal inflammation 95.33 10.22 15 181812 40127 50383170
Mood altered 93.35 10.22 166 181661 12607 50410690
Nightmare 92.77 10.22 189 181638 15897 50407400
Dissociation 92.39 10.22 72 181755 2219 50421078
Injection site pain 91.99 10.22 161 181666 110863 50312434
Drug withdrawal syndrome neonatal 90.15 10.22 65 181762 1776 50421521
Torsade de pointes 89.33 10.22 156 181671 11679 50411618
Pemphigus 89.29 10.22 186 181641 119980 50303317
Circulatory collapse 88.19 10.22 211 181616 19789 50403508
Urinary tract infection 87.87 10.22 460 181367 223560 50199737
Foetal exposure during pregnancy 86.44 10.22 255 181572 27104 50396193
Sleep-related eating disorder 86.19 10.22 46 181781 722 50422575
Myoclonus 85.81 10.22 172 181655 14298 50408999
Influenza 85.48 10.22 118 181709 89420 50333877
Bipolar I disorder 84.58 10.22 58 181769 1460 50421837
Gastric pH decreased 83.86 10.22 43 181784 619 50422678
Pyrexia 83.73 10.22 918 180909 379285 50044012
Psychomotor skills impaired 83.52 10.22 65 181762 1999 50421298
Atrial fibrillation 82.97 10.22 149 181678 101596 50321701
Mental disorder 81.29 10.22 217 181610 21774 50401523
Osteoarthritis 81.16 10.22 76 181751 68530 50354767
Hypotonia 80.16 10.22 121 181706 8013 50415284
Haemoglobin decreased 80.09 10.22 215 181612 127001 50296296
Hyperreflexia 79.41 10.22 95 181732 5023 50418274
Musculoskeletal pain 78.49 10.22 86 181741 72091 50351206
Long QT syndrome 78.12 10.22 73 181754 2894 50420403
Discomfort 77.82 10.22 171 181656 108209 50315088
Drug screen positive 76.95 10.22 77 181750 3325 50419972
Drooling 75.45 10.22 76 181751 3308 50419989
Cellulitis 75.19 10.22 86 181741 70712 50352585
Anger 74.88 10.22 141 181686 11192 50412105
Impulse-control disorder 74.83 10.22 40 181787 630 50422667
Anti-cyclic citrullinated peptide antibody positive 74.69 10.22 86 181741 70501 50352796
Coma blister 74.49 10.22 26 181801 129 50423168
Drug level increased 72.10 10.22 191 181636 19077 50404220
Panic attack 71.64 10.22 191 181636 19151 50404146
Psychomotor retardation 71.20 10.22 74 181753 3344 50419953
Bronchitis 71.01 10.22 169 181658 103990 50319307
Cognitive disorder 70.54 10.22 330 181497 43793 50379504
Bone pain 70.50 10.22 41 181786 47188 50376109
Skin ulcer 69.98 10.22 20 181807 35298 50387999
Generalised tonic-clonic seizure 69.98 10.22 231 181596 26079 50397218
Prescribed overdose 69.80 10.22 159 181668 14441 50408856
Psychiatric symptom 69.55 10.22 84 181743 4486 50418811
Flushing 69.46 10.22 83 181744 66932 50356365
Platelet count decreased 69.01 10.22 163 181664 100563 50322734
Oromandibular dystonia 68.85 10.22 33 181794 407 50422890
Sleep disorder due to general medical condition, insomnia type 67.73 10.22 15 181812 31432 50391865
Irritable bowel syndrome 66.93 10.22 52 181775 51389 50371908
Infarction 66.59 10.22 60 181767 2268 50421029
Injection site pruritus 66.37 10.22 31 181796 40380 50382917
Electrocardiogram QRS complex shortened 66.25 10.22 32 181795 402 50422895
Embolism venous 66.24 10.22 62 181765 2463 50420834
Apathy 65.63 10.22 106 181721 7442 50415855
Amenorrhoea 65.56 10.22 113 181714 8371 50414926
Accidental overdose 65.50 10.22 186 181641 19347 50403950
Fluid retention 63.65 10.22 53 181774 50596 50372701
Glossodynia 63.57 10.22 208 181619 115361 50307936
Hypothermia 63.25 10.22 136 181691 11880 50411417
Injection site swelling 62.73 10.22 36 181791 41737 50381560
Exposure via ingestion 62.59 10.22 63 181764 2740 50420557
Depressed mood 62.33 10.22 265 181562 33758 50389539
Breast cancer 61.55 10.22 39 181788 42851 50380446
Red blood cell sedimentation rate increased 61.43 10.22 15 181812 29401 50393896
Stupor 61.41 10.22 70 181757 3513 50419784
Chest discomfort 61.19 10.22 153 181674 92569 50330728
Upper respiratory tract infection 60.75 10.22 89 181738 65809 50357488
Hypotonia neonatal 60.10 10.22 40 181787 957 50422340
Folliculitis 60.06 10.22 33 181794 39192 50384105
Pericarditis 59.97 10.22 120 181707 78569 50344728
Tachyphrenia 58.79 10.22 43 181784 1202 50422095
Abdominal pain 58.66 10.22 554 181273 235674 50187623
Chest pain 58.25 10.22 384 181443 176498 50246799
Dyspnoea exertional 57.99 10.22 59 181768 51174 50372123
Bone marrow failure 57.85 10.22 14 181813 27610 50395687
Gastrointestinal haemorrhage 57.44 10.22 110 181717 73211 50350086
Abnormal weight gain 57.18 10.22 45 181782 1407 50421890
Drug dependence 56.64 10.22 178 181649 19581 50403716
Osteonecrosis of jaw 56.50 10.22 23 181804 32503 50390794
Dementia 56.27 10.22 155 181672 15842 50407455
Potentiating drug interaction 56.22 10.22 69 181758 3747 50419550
Device expulsion 55.86 10.22 17 181810 28805 50394492
Muscle injury 55.70 10.22 32 181795 37079 50386218
Urinary hesitation 55.51 10.22 51 181776 1978 50421319
Plasma cell myeloma 54.65 10.22 22 181805 31300 50391997
Interstitial lung disease 53.90 10.22 67 181760 53109 50370188
Sympathomimetic effect 53.66 10.22 16 181811 42 50423255
Diverticulitis 53.65 10.22 26 181801 33156 50390141
H1N1 influenza 53.42 10.22 45 181782 1552 50421745
Logorrhoea 53.30 10.22 53 181774 2271 50421026
Suicidal behaviour 53.11 10.22 53 181774 2281 50421016
Asthenia 52.93 10.22 817 181010 318225 50105072
Euphoric mood 52.88 10.22 69 181758 3986 50419311
Pancytopenia 52.88 10.22 142 181685 83888 50339409
Insurance issue 52.78 10.22 55 181772 2493 50420804
Basal cell carcinoma 52.66 10.22 10 181817 23346 50399951
Bradypnoea 52.59 10.22 60 181767 3014 50420283
Abdominal pain upper 52.37 10.22 346 181481 158963 50264334
Posture abnormal 52.33 10.22 50 181777 2039 50421258
Pancreatitis 52.29 10.22 296 181531 42318 50380979
Polydipsia 51.81 10.22 60 181767 3064 50420233
Pleural effusion 51.74 10.22 137 181690 81317 50341980
Psychiatric decompensation 51.74 10.22 40 181787 1218 50422079
Blood triglycerides increased 51.66 10.22 121 181706 11191 50412106
Enuresis 51.52 10.22 50 181777 2079 50421218
Faecaloma 51.46 10.22 92 181735 7016 50416281
Myocarditis 51.42 10.22 98 181729 7849 50415448
Conversion disorder 51.40 10.22 44 181783 1552 50421745
Inflammation 51.36 10.22 78 181749 56834 50366463
Myoglobin urine present 51.34 10.22 26 181801 364 50422933
Nasal congestion 51.19 10.22 65 181762 51055 50372242
Injection site reaction 50.75 10.22 63 181764 49969 50373328
Tic 50.72 10.22 39 181788 1178 50422119
Chills 49.79 10.22 179 181648 96508 50326789
Prescribed underdose 49.75 10.22 148 181679 15801 50407496
Hypersomnia 49.58 10.22 144 181683 15170 50408127
Palmar-plantar erythrodysaesthesia syndrome 48.89 10.22 7 181820 20091 50403206
Impulsive behaviour 48.60 10.22 41 181786 1417 50421880
Mutism 48.45 10.22 40 181787 1341 50421956
Myocardial infarction 48.42 10.22 161 181666 88866 50334431
Productive cough 47.76 10.22 72 181755 52622 50370675
Hypersexuality 47.62 10.22 26 181801 428 50422869
Dyspepsia 47.54 10.22 124 181703 73973 50349324
Jaundice cholestatic 47.50 10.22 74 181753 5037 50418260
Gastrooesophageal reflux disease 47.45 10.22 130 181697 76298 50346999
Menstrual disorder 47.38 10.22 68 181759 4302 50418995
Behaviour disorder 46.85 10.22 50 181777 2330 50420967
Clonus 46.79 10.22 66 181761 4109 50419188
Anaemia of pregnancy 46.79 10.22 15 181812 54 50423243
Cytomegalovirus infection 46.76 10.22 5 181822 17957 50405340
Hyperkinesia 46.70 10.22 40 181787 1412 50421885
Mobility decreased 46.69 10.22 140 181687 79808 50343489
Myalgia 46.62 10.22 259 181568 124060 50299237
C-reactive protein abnormal 46.18 10.22 21 181806 27788 50395509
Tension 45.72 10.22 53 181774 2709 50420588
Bundle branch block right 45.63 10.22 69 181758 4576 50418721
Weight decreased 45.53 10.22 542 181285 220703 50202594
Parkinsonian gait 45.50 10.22 25 181802 417 50422880
Urine osmolarity increased 45.09 10.22 17 181810 109 50423188
Intestinal pseudo-obstruction 44.85 10.22 30 181797 724 50422573
Aspiration 44.41 10.22 101 181726 9163 50414134
Rhinorrhoea 44.36 10.22 73 181754 51510 50371787
Joint stiffness 44.26 10.22 27 181800 30281 50393016
Schizophreniform disorder 44.25 10.22 15 181812 67 50423230
Leukopenia 44.18 10.22 403 181424 67125 50356172
Rabbit syndrome 44.08 10.22 22 181805 298 50422999
Bradycardia 43.95 10.22 388 181439 64038 50359259
Meconium aspiration syndrome 43.88 10.22 11 181816 10 50423287
Hyperthermia 43.87 10.22 90 181737 7606 50415691
Full blood count decreased 43.63 10.22 13 181814 22333 50400964
Contusion 43.56 10.22 231 181596 111952 50311345
Epistaxis 43.39 10.22 104 181723 63850 50359447
Ascites 43.26 10.22 39 181788 35822 50387475
Feeling of body temperature change 43.08 10.22 65 181762 4302 50418995
Affect lability 43.02 10.22 98 181729 8900 50414397
Alcohol abuse 42.95 10.22 43 181784 1858 50421439
Nephrogenic diabetes insipidus 42.90 10.22 31 181796 850 50422447
Thrombosis 42.66 10.22 85 181742 55748 50367549
Acute psychosis 42.58 10.22 46 181781 2174 50421123
Osteonecrosis 42.36 10.22 14 181813 22503 50400794
Action tremor 42.31 10.22 21 181806 281 50423016
Major depression 42.23 10.22 83 181744 6801 50416496
Dry skin 42.14 10.22 56 181771 43135 50380162
Postural tremor 42.12 10.22 19 181808 202 50423095
Therapeutic product effect incomplete 41.64 10.22 178 181649 91337 50331960
Blister 41.46 10.22 162 181665 85256 50338041
Decreased appetite 41.42 10.22 492 181335 200431 50222866
Neoplasm progression 41.17 10.22 27 181800 29130 50394167
Negativism 41.07 10.22 22 181805 348 50422949
Burning mouth syndrome 41.01 10.22 23 181804 400 50422897
Homicide 40.96 10.22 22 181805 350 50422947
Ventricular fibrillation 40.86 10.22 106 181721 10453 50412844
Loss of personal independence in daily activities 40.67 10.22 123 181704 69927 50353370
Muscle twitching 40.60 10.22 135 181692 15296 50408001
Ataxia 40.26 10.22 125 181702 13661 50409636
Injection site bruising 39.76 10.22 44 181783 36724 50386573
Knee arthroplasty 39.75 10.22 42 181785 35804 50387493
Hypervolaemia 39.70 10.22 21 181806 25478 50397819
Adjustment disorder with mixed anxiety and depressed mood 39.70 10.22 14 181813 72 50423225
Psychotic behaviour 39.48 10.22 25 181802 548 50422749
Right ventricular false tendon 39.43 10.22 10 181817 10 50423287
Helicobacter infection 39.42 10.22 74 181753 49628 50373669
COVID-19 39.23 10.22 67 181760 46595 50376702
Product dose omission issue 39.11 10.22 447 181380 183391 50239906
Anaphylactic reaction 39.02 10.22 85 181742 53970 50369327
Conjunctival abrasion 38.95 10.22 11 181816 22 50423275
Psoriasis 38.75 10.22 123 181704 68877 50354420
Mental impairment 38.75 10.22 113 181714 11931 50411366
Gastrointestinal sounds abnormal 38.60 10.22 56 181771 3578 50419719
Granulocytopenia 38.24 10.22 68 181759 5163 50418134
Localised infection 38.21 10.22 22 181805 25463 50397834
Thermal burn 38.09 10.22 65 181762 4776 50418521
Amniotic fluid volume increased 38.09 10.22 16 181811 141 50423156
Hyperammonaemia 37.92 10.22 64 181763 4660 50418637
Product substitution issue 37.89 10.22 124 181703 13933 50409364
Throat irritation 37.55 10.22 32 181795 30207 50393090
Distributive shock 37.39 10.22 28 181799 812 50422485
Pain in jaw 37.31 10.22 50 181777 38378 50384919
Myelosuppression 37.22 10.22 3 181824 13514 50409783
Hyperphagia 37.11 10.22 36 181791 1496 50421801
Hypertension 36.99 10.22 535 181292 210668 50212629
Social anxiety disorder 36.71 10.22 21 181806 380 50422917
Slow response to stimuli 36.55 10.22 28 181799 841 50422456
Laboratory test abnormal 36.30 10.22 19 181808 23189 50400108
Surgery 36.26 10.22 33 181794 30172 50393125
Disinhibition 36.06 10.22 27 181800 783 50422514
Thrombocytopenia 35.82 10.22 290 181537 127383 50295914
Alcohol poisoning 35.76 10.22 38 181789 1762 50421535
Medication error 35.58 10.22 237 181590 35867 50387430
Tongue biting 35.55 10.22 33 181794 1297 50422000
Rheumatoid factor positive 35.49 10.22 79 181748 49780 50373517
Congenital vesicoureteric reflux 35.41 10.22 10 181817 20 50423277
Alcohol interaction 35.25 10.22 41 181786 2103 50421194
Clostridium difficile colitis 35.23 10.22 10 181817 17732 50405565
Duodenal ulcer perforation 35.22 10.22 69 181758 45542 50377755
Emotional disorder 35.19 10.22 108 181719 11728 50411569
Renal papillary necrosis 35.16 10.22 17 181810 214 50423083
Stereotypy 34.96 10.22 20 181807 362 50422935
Hypertonia 34.82 10.22 56 181771 3917 50419380
Arrhythmia 34.80 10.22 221 181606 32911 50390386
Self-medication 34.56 10.22 42 181785 2257 50421040
Foot deformity 34.33 10.22 13 181814 19197 50404100
Attention deficit hyperactivity disorder 34.30 10.22 43 181784 2386 50420911
Metastases to bone 34.18 10.22 11 181816 17984 50405313
Ear infection 34.10 10.22 26 181801 25944 50397353
Blood pressure increased 33.96 10.22 310 181517 132822 50290475
Homicidal ideation 33.94 10.22 36 181791 1666 50421631
Inappropriate affect 33.93 10.22 26 181801 781 50422516
Congenital hand malformation 33.93 10.22 18 181809 279 50423018
Coronary artery disease 33.90 10.22 34 181793 29692 50393605
Hyperthermia malignant 33.72 10.22 25 181802 714 50422583
Metastases to liver 33.67 10.22 15 181812 20089 50403208
Accidental poisoning 33.54 10.22 23 181804 579 50422718
Apnoea 33.45 10.22 76 181751 6890 50416407
Congenital thrombocytopenia 33.41 10.22 11 181816 44 50423253
Viral infection 33.40 10.22 35 181792 29951 50393346
Renal failure 33.33 10.22 235 181592 106398 50316899
Nuchal rigidity 33.30 10.22 23 181804 586 50422711
Wound 33.14 10.22 233 181594 105561 50317736
Borderline personality disorder 33.03 10.22 24 181803 664 50422633
Osteomyelitis 32.52 10.22 20 181807 22333 50400964
Electrocardiogram repolarisation abnormality 32.51 10.22 30 181797 1170 50422127
Self esteem decreased 32.32 10.22 22 181805 547 50422750
Femur fracture 32.23 10.22 53 181774 37411 50385886
Drug use disorder 32.14 10.22 47 181780 3025 50420272
Depressive symptom 32.10 10.22 48 181779 3152 50420145
Nephrolithiasis 31.83 10.22 47 181780 34646 50388651
Oedema peripheral 31.70 10.22 389 181438 157572 50265725
Incontinence 31.47 10.22 93 181734 9892 50413405
Oropharyngeal pain 31.44 10.22 158 181669 77643 50345654
Feeling guilty 31.31 10.22 21 181806 509 50422788
Rectal haemorrhage 30.94 10.22 57 181770 38501 50384796
Colitis 30.88 10.22 57 181770 38472 50384825
Acute myeloid leukaemia 30.87 10.22 8 181819 15066 50408231
Vomiting 30.78 10.22 1348 180479 459410 49963887
Self-injurious ideation 30.75 10.22 39 181788 2190 50421107
Rash pruritic 30.74 10.22 80 181747 47766 50375531
Wrong patient received product 30.48 10.22 34 181793 1666 50421631
Akinesia 30.41 10.22 32 181795 1467 50421830
Emotional poverty 30.29 10.22 17 181810 296 50423001
Peripartum cardiomyopathy 30.14 10.22 13 181814 123 50423174
Formication 30.07 10.22 50 181777 3596 50419701
Neutropenic sepsis 29.96 10.22 7 181820 14140 50409157
Hypercalcaemia 29.88 10.22 24 181803 23328 50399969
Pulmonary arterial hypertension 29.81 10.22 18 181809 20301 50402996
Hyperhidrosis 29.74 10.22 469 181358 88957 50334340
Ventricular tachycardia 29.57 10.22 124 181703 15697 50407600
Neoplasm malignant 29.56 10.22 25 181802 23690 50399607
Schizoaffective disorder 29.49 10.22 38 181789 2168 50421129
Asthma 29.35 10.22 194 181633 89143 50334154
Metabolic acidosis 29.20 10.22 239 181588 38586 50384711
Cyanosis 29.16 10.22 120 181707 15064 50408233
Stoma site discharge 29.10 10.22 29 181798 1246 50422051
Language disorder 29.08 10.22 34 181793 1754 50421543
Slow speech 28.96 10.22 29 181798 1253 50422044
Osteoporosis 28.86 10.22 75 181752 44804 50378493
Orthostatic hypotension 28.74 10.22 193 181634 29288 50394009
Drug level above therapeutic 28.71 10.22 51 181776 3869 50419428
Muscle disorder 28.58 10.22 54 181773 4296 50419001
Hypertonia neonatal 28.47 10.22 15 181812 229 50423068
Blood glucose increased 28.42 10.22 386 181441 70938 50352359
Bone disorder 28.38 10.22 16 181811 18736 50404561
Alcoholism 28.36 10.22 32 181795 1588 50421709
Single umbilical artery 28.36 10.22 15 181812 231 50423066
Floppy iris syndrome 28.35 10.22 12 181815 108 50423189
Adrenal insufficiency 28.33 10.22 8 181819 14235 50409062
Ammonia increased 28.31 10.22 53 181774 4188 50419109
Torticollis 28.22 10.22 33 181794 1703 50421594
Status epilepticus 28.19 10.22 109 181718 13297 50410000
Nodule 27.98 10.22 13 181814 16990 50406307
Tonic clonic movements 27.98 10.22 28 181799 1209 50422088
Herbal interaction 27.88 10.22 11 181816 81 50423216
Urine sodium increased 27.88 10.22 11 181816 81 50423216
Respiratory tract infection 27.82 10.22 45 181782 31972 50391325
Full blood count abnormal 27.54 10.22 26 181801 23362 50399935
Decreased interest 27.54 10.22 43 181784 2933 50420364
Antidepressant drug level increased 27.52 10.22 15 181812 246 50423051
Dysphagia 27.49 10.22 411 181416 77107 50346190
Epilepsy 27.24 10.22 151 181676 21416 50401881
Injection site rash 27.20 10.22 12 181815 16165 50407132
Neck pain 27.20 10.22 109 181718 56958 50366339
Renal impairment 27.07 10.22 160 181667 75501 50347796
Personality change due to a general medical condition 26.89 10.22 11 181816 90 50423207
Bursitis 26.79 10.22 24 181803 22111 50401186
Social avoidant behaviour 26.70 10.22 41 181786 2756 50420541
Anaphylactic shock 26.69 10.22 20 181807 20135 50403162
Memory impairment 26.69 10.22 417 181410 78943 50344354
Parosmia 26.62 10.22 53 181774 4383 50418914
Bone density decreased 26.61 10.22 4 181823 11071 50412226
Blunted affect 26.56 10.22 14 181813 214 50423083
Immunodeficiency 26.55 10.22 10 181817 14818 50408479
Joint effusion 26.49 10.22 7 181820 13014 50410283
Lung disorder 26.48 10.22 78 181749 44721 50378576
Respiratory disorder neonatal 26.42 10.22 24 181803 917 50422380
Agranulocytosis 26.41 10.22 149 181678 21272 50402025
Morbid thoughts 26.23 10.22 19 181808 523 50422774
Idiopathic intracranial hypertension 26.13 10.22 37 181790 2312 50420985
Injection site urticaria 25.96 10.22 6 181821 12211 50411086
Pyramidal tract syndrome 25.95 10.22 16 181811 334 50422963
Incoherent 25.94 10.22 51 181776 4179 50419118
Oral pain 25.93 10.22 31 181796 25002 50398295
Merycism 25.93 10.22 13 181814 178 50423119
Atrioventricular block first degree 25.82 10.22 64 181763 6137 50417160
Myelodysplastic syndrome 25.80 10.22 11 181816 15121 50408176
Paralysis 25.71 10.22 79 181748 8585 50414712
Mouth ulceration 25.67 10.22 38 181789 27986 50395311
Neonatal disorder 25.61 10.22 19 181808 543 50422754
Ulcer 25.54 10.22 21 181806 20179 50403118
Acute kidney injury 25.52 10.22 624 181203 227434 50195863
Septic shock 25.52 10.22 112 181715 57063 50366234
Limb discomfort 25.41 10.22 30 181797 24327 50398970
Meconium in amniotic fluid 25.35 10.22 14 181813 236 50423061
Persistent genital arousal disorder 25.24 10.22 14 181813 238 50423059
Gastric disorder 25.23 10.22 42 181785 29506 50393791
Hypoglycaemia neonatal 25.18 10.22 23 181804 885 50422412
Physical assault 25.18 10.22 23 181804 885 50422412
Protein C increased 25.15 10.22 11 181816 108 50423189
Pallor 25.14 10.22 156 181671 23043 50400254
Food interaction 25.12 10.22 20 181807 636 50422661
Amnesia 25.04 10.22 247 181580 42013 50381284
Mental status changes 25.02 10.22 219 181608 36053 50387244
Small for dates baby 24.90 10.22 45 181782 3460 50419837
Sudden death 24.86 10.22 80 181747 8911 50414386
Congenital hearing disorder 24.79 10.22 7 181820 14 50423283
Cervix neoplasm 24.53 10.22 13 181814 201 50423096
Tooth infection 24.48 10.22 10 181817 14102 50409195
Food craving 24.47 10.22 28 181799 1411 50421886
Tubulointerstitial nephritis 24.47 10.22 12 181815 15199 50408098
Chorea 24.37 10.22 27 181800 1313 50421984
Fungal infection 24.30 10.22 44 181783 29921 50393376
Pulmonary mass 24.21 10.22 19 181808 18686 50404611
Pulmonary embolism 24.17 10.22 506 181321 101198 50322099
Post-traumatic stress disorder 24.15 10.22 50 181777 4253 50419044
Electrocardiogram abnormal 24.13 10.22 71 181756 7534 50415763
Eosinopenia 24.10 10.22 8 181819 33 50423264
Neonatal respiratory distress syndrome 24.07 10.22 38 181789 2616 50420681
Sinus congestion 24.07 10.22 10 181817 13961 50409336
Aphasia 23.96 10.22 180 181647 28314 50394983
Tenderness 23.85 10.22 19 181808 18546 50404751
Therapeutic product ineffective 23.81 10.22 26 181801 1244 50422053
Bacteraemia 23.81 10.22 11 181816 14422 50408875
Device stimulation issue 23.70 10.22 9 181818 59 50423238
Urinary incontinence 23.61 10.22 178 181649 28030 50395267
Sinus disorder 23.58 10.22 19 181808 18439 50404858
Malignant melanoma 23.50 10.22 4 181823 10104 50413193
Right ventricular failure 23.43 10.22 14 181813 15879 50407418
Decreased bronchial secretion 23.33 10.22 9 181818 62 50423235
Drug screen false positive 23.21 10.22 21 181806 798 50422499
Neurodegenerative disorder 23.19 10.22 14 181813 281 50423016
Dependence 23.06 10.22 31 181796 1844 50421453
Suppressed lactation 22.88 10.22 16 181811 416 50422881
Gastritis 22.87 10.22 53 181774 32930 50390367
Disseminated intravascular coagulation 22.70 10.22 17 181810 17118 50406179
Hyporesponsive to stimuli 22.37 10.22 22 181805 930 50422367
Eye movement disorder 22.28 10.22 50 181777 4495 50418802
Generalised anxiety disorder 22.24 10.22 30 181797 1790 50421507
Negative thoughts 22.21 10.22 21 181806 845 50422452
Schizoaffective disorder bipolar type 22.20 10.22 10 181817 106 50423191
Bladder dilatation 22.15 10.22 20 181807 758 50422539
Blood calcium decreased 22.14 10.22 25 181802 20681 50402616
Cardiac failure 22.11 10.22 171 181656 75869 50347428
Electrocardiogram QT interval abnormal 22.11 10.22 11 181816 148 50423149
Toxic encephalopathy 22.00 10.22 56 181771 5459 50417838
Gastroenteritis viral 21.99 10.22 21 181806 18765 50404532
Colitis ulcerative 21.97 10.22 17 181810 16837 50406460
Depressive delusion 21.95 10.22 6 181821 10 50423287
Feelings of worthlessness 21.91 10.22 14 181813 312 50422985
Spasmodic dysphonia 21.86 10.22 9 181818 75 50423222
Neonatal hypotension 21.71 10.22 10 181817 112 50423185
Diabetes insipidus 21.65 10.22 34 181793 2330 50420967
Disturbance in sexual arousal 21.65 10.22 9 181818 77 50423220
Vitamin K decreased 21.59 10.22 6 181821 11 50423286
Parasomnia 21.55 10.22 15 181812 387 50422910
Pupillary light reflex tests abnormal 21.53 10.22 11 181816 157 50423140
Seasonal allergy 21.53 10.22 13 181814 14663 50408634
Cytopenia 21.47 10.22 3 181824 8772 50414525
Pressure of speech 21.45 10.22 17 181810 537 50422760
Pulmonary hypertension 21.37 10.22 56 181771 33361 50389936
Colon cancer 21.20 10.22 3 181824 8688 50414609
Blepharospasm 21.14 10.22 38 181789 2910 50420387
Affective disorder 21.07 10.22 53 181774 5128 50418169
Diverticulum 21.04 10.22 6 181821 10608 50412689
Haemophagocytic lymphohistiocytosis 21.01 10.22 3 181824 8630 50414667
Increased appetite 20.98 10.22 72 181755 8289 50415008
Hyperkalaemia 20.98 10.22 95 181732 47994 50375303
Stoma site hypergranulation 20.89 10.22 13 181814 276 50423021
Atrial septal defect 20.89 10.22 60 181767 6281 50417016
Electrocardiogram T wave inversion 20.83 10.22 40 181787 3221 50420076
Pneumonitis 20.80 10.22 47 181780 29463 50393834
Neuropsychiatric symptoms 20.79 10.22 17 181810 562 50422735
Musculoskeletal disorder 20.77 10.22 19 181808 17330 50405967
Abulia 20.74 10.22 15 181812 412 50422885
Device difficult to use 20.72 10.22 5 181822 9881 50413416
Movement disorder 20.66 10.22 121 181706 17511 50405786
Procedural pain 20.65 10.22 12 181815 13820 50409477
Tongue spasm 20.63 10.22 8 181819 56 50423241
Distal intestinal obstruction syndrome 20.46 10.22 14 181813 351 50422946
Ventricular arrhythmia 20.42 10.22 40 181787 3269 50420028
Sleep disorder 20.41 10.22 304 181523 56979 50366318
Breast engorgement 20.35 10.22 9 181818 91 50423206
Obsessive-compulsive symptom 20.34 10.22 7 181820 33 50423264
Compartment syndrome 20.27 10.22 30 181797 1952 50421345
Pulmonary artery stenosis congenital 20.18 10.22 12 181815 234 50423063
Foetal death 20.14 10.22 70 181757 8110 50415187
False positive investigation result 20.09 10.22 16 181811 509 50422788
Anterior displaced anus 20.06 10.22 6 181821 16 50423281
Inappropriate antidiuretic hormone secretion 20.05 10.22 97 181730 13046 50410251
Starvation ketoacidosis 20.04 10.22 8 181819 61 50423236
Hepatic enzyme increased 20.03 10.22 360 181467 137020 50286277
Ear pain 19.97 10.22 45 181782 28238 50395059
Somatic symptom disorder of pregnancy 19.93 10.22 9 181818 96 50423201
Ileus 19.73 10.22 97 181730 13132 50410165
Sense of a foreshortened future 19.71 10.22 5 181822 5 50423292
Apraxia 19.70 10.22 26 181801 1519 50421778
Type 1 diabetes mellitus 19.66 10.22 38 181789 3075 50420222
Hospitalisation 19.65 10.22 153 181674 67784 50355513
Teratoma benign 19.60 10.22 8 181819 65 50423232
Hyponatraemia 19.59 10.22 468 181359 95671 50327626
Transfusion 19.55 10.22 11 181816 12894 50410403
Product quality issue 19.51 10.22 52 181775 30806 50392491
Crying 19.50 10.22 133 181694 20283 50403014
Haemoptysis 19.47 10.22 39 181788 25534 50397763
Tuberculosis 19.44 10.22 6 181821 10077 50413220
Binge eating 19.40 10.22 14 181813 383 50422914
Resting tremor 19.38 10.22 18 181809 708 50422589
Injection site warmth 19.36 10.22 13 181814 13853 50409444
Resuscitation 19.31 10.22 21 181806 1000 50422297
Haemorrhoids 19.31 10.22 24 181803 19029 50404268
Fear of weight gain 19.30 10.22 6 181821 19 50423278
Central obesity 19.29 10.22 21 181806 1001 50422296
Tendonitis 19.17 10.22 19 181808 16686 50406611
Burning sensation 19.10 10.22 91 181736 45355 50377942
Bruxism 19.07 10.22 37 181790 3003 50420294
Acidosis 18.99 10.22 80 181747 10147 50413150
Labelled drug-drug interaction issue 18.95 10.22 12 181815 263 50423034
Uveitis 18.95 10.22 5 181822 9305 50413992
Patient uncooperative 18.90 10.22 10 181817 154 50423143
Vestibular migraine 18.89 10.22 11 181816 206 50423091
Cystitis 18.87 10.22 89 181738 44475 50378822
Bradycardia neonatal 18.86 10.22 19 181808 827 50422470
Cytokine release syndrome 18.83 10.22 4 181823 8630 50414667
Osteopenia 18.80 10.22 20 181807 16998 50406299
Skin reaction 18.80 10.22 9 181818 11559 50411738
Convulsive threshold lowered 18.79 10.22 13 181814 332 50422965
Lacrimation increased 18.74 10.22 20 181807 16972 50406325
Cerebellar atrophy 18.70 10.22 17 181810 650 50422647
Hip arthroplasty 18.70 10.22 52 181775 30377 50392920
Nystagmus 18.69 10.22 53 181774 5508 50417789
Radial nerve palsy 18.66 10.22 15 181812 484 50422813
Diabetic ketoacidosis 18.63 10.22 119 181708 17753 50405544
Psychogenic tremor 18.63 10.22 6 181821 22 50423275
Haematotoxicity 18.63 10.22 3 181824 7892 50415405
Upper-airway cough syndrome 18.57 10.22 4 181823 8546 50414751
Ventricular extrasystoles 18.56 10.22 81 181746 10435 50412862
Breast cancer metastatic 18.54 10.22 7 181820 10357 50412940
Child abuse 18.53 10.22 4 181823 0 50423297
Delusional perception 18.53 10.22 11 181816 214 50423083
Syncope 18.51 10.22 493 181334 102509 50320788
Dementia with Lewy bodies 18.44 10.22 12 181815 276 50423021
Skin necrosis 18.37 10.22 8 181819 10859 50412438
Clostridium difficile infection 18.36 10.22 40 181787 25399 50397898
Antipsychotic drug level below therapeutic 18.26 10.22 12 181815 281 50423016
Aortic bruit 18.22 10.22 6 181821 24 50423273
Ballismus 18.16 10.22 8 181819 80 50423217
Pulseless electrical activity 18.13 10.22 60 181767 6781 50416516
Muscle spasticity 18.10 10.22 21 181806 17163 50406134
Pupil fixed 18.09 10.22 25 181802 1527 50421770
Aplastic anaemia 18.01 10.22 3 181824 7700 50415597
Head titubation 17.94 10.22 17 181810 686 50422611
Dermatitis 17.79 10.22 15 181812 14236 50409061
Unevaluable event 17.79 10.22 95 181732 45971 50377326
Ill-defined disorder 17.78 10.22 119 181708 54535 50368762
C-reactive protein increased 17.72 10.22 153 181674 66321 50356976
Antisocial behaviour 17.71 10.22 12 181815 296 50423001
Megacolon 17.70 10.22 26 181801 1680 50421617
Product storage error 17.70 10.22 11 181816 12213 50411084
Selective eating disorder 17.69 10.22 27 181800 1805 50421492
Lymphocyte count decreased 17.66 10.22 43 181784 26264 50397033
Tongue movement disturbance 17.62 10.22 11 181816 235 50423062
Flatulence 17.62 10.22 51 181776 29407 50393890
Antidepressant drug level above therapeutic 17.57 10.22 13 181814 370 50422927
Reduced facial expression 17.57 10.22 25 181802 1569 50421728
Sudden cardiac death 17.56 10.22 28 181799 1944 50421353
Muscular weakness 17.56 10.22 238 181589 94775 50328522
Angina pectoris 17.43 10.22 43 181784 26145 50397152
Personality disorder 17.34 10.22 44 181783 4280 50419017
Haematochezia 17.27 10.22 79 181748 39803 50383494
Poverty of speech 17.26 10.22 12 181815 309 50422988
Spinal stenosis 17.24 10.22 14 181813 13536 50409761
Neurological decompensation 17.23 10.22 30 181797 2240 50421057
Screaming 17.18 10.22 35 181792 2943 50420354
Compulsive sexual behaviour 17.14 10.22 7 181820 57 50423240
Perinatal depression 17.12 10.22 15 181812 546 50422751
Chronic kidney disease 17.09 10.22 79 181748 39692 50383605
Dehydration 17.07 10.22 417 181410 152032 50271265
Bipolar II disorder 17.06 10.22 11 181816 249 50423048
Insomnia 17.06 10.22 780 181047 174085 50249212
Musculoskeletal discomfort 17.03 10.22 17 181810 14881 50408416
Candida infection 16.96 10.22 37 181790 23486 50399811
Eye irritation 16.94 10.22 22 181805 17118 50406179
Therapy interrupted 16.88 10.22 29 181798 20123 50403174
Hostility 16.84 10.22 26 181801 1756 50421541
Eye haemorrhage 16.84 10.22 3 181824 7332 50415965
Migraine 16.80 10.22 181 181646 75099 50348198
Abdominal pain lower 16.72 10.22 33 181794 21723 50401574
Faeces discoloured 16.67 10.22 20 181807 16104 50407193
Gait deviation 16.63 10.22 7 181820 62 50423235
Post procedural haemorrhage 16.63 10.22 3 181824 7267 50416030
Hot flush 16.55 10.22 92 181735 44077 50379220
Metastases to central nervous system 16.54 10.22 10 181817 11272 50412025
Dropped head syndrome 16.53 10.22 8 181819 101 50423196
Atelectasis 16.52 10.22 25 181802 18245 50405052
Cerebrovascular accident 16.49 10.22 240 181587 94440 50328857
Gastroenteritis 16.47 10.22 37 181790 23244 50400053
Tachypnoea 16.41 10.22 99 181728 14478 50408819
Hypocalcaemia 16.35 10.22 46 181781 26770 50396527
Device related infection 16.33 10.22 31 181796 20704 50402593
Dysgeusia 16.31 10.22 78 181749 38838 50384459
Somatic hallucination 16.30 10.22 4 181823 3 50423294
Lung neoplasm malignant 16.23 10.22 19 181808 15465 50407832
Exostosis 16.17 10.22 11 181816 11642 50411655
Hypoacusis 16.14 10.22 31 181796 20616 50402681
Dysuria 16.12 10.22 165 181662 28339 50394958
Postmortem blood drug level abnormal 16.08 10.22 12 181815 346 50422951
Grandiosity 16.07 10.22 11 181816 276 50423021
Pneumothorax 16.06 10.22 16 181811 14018 50409279
Feeling jittery 16.06 10.22 81 181746 11079 50412218
Labelled drug-food interaction issue 16.04 10.22 5 181822 16 50423281
Ileus paralytic 16.02 10.22 41 181786 4009 50419288
Cortisol increased 16.02 10.22 12 181815 348 50422949
Ageusia 15.98 10.22 11 181816 11572 50411725
Indifference 15.86 10.22 8 181819 111 50423186
Metastases to lymph nodes 15.85 10.22 3 181824 7021 50416276
Hallucination, olfactory 15.84 10.22 10 181817 218 50423079
Dysphonia 15.69 10.22 79 181748 38813 50384484
Gout 15.69 10.22 11 181816 11459 50411838
Deafness 15.66 10.22 20 181807 15671 50407626
Progressive multifocal leukoencephalopathy 15.65 10.22 11 181816 11446 50411851
Pulmonary fibrosis 15.59 10.22 41 181786 24396 50398901
Induced abortion failed 15.56 10.22 10 181817 225 50423072
Post procedural infection 15.55 10.22 4 181823 7572 50415725
Skin exfoliation 15.51 10.22 65 181762 33547 50389750
No adverse event 15.45 10.22 65 181762 33513 50389784
Infusion site pain 15.41 10.22 13 181814 12333 50410964
Swollen tongue 15.37 10.22 164 181663 28466 50394831
Pneumonia viral 15.25 10.22 3 181824 6831 50416466
Hypoglycaemia 15.24 10.22 274 181553 53307 50369990
Brain oedema 15.22 10.22 86 181741 12284 50411013
Echolalia 15.21 10.22 9 181818 174 50423123
Antipsychotic drug level above therapeutic 15.21 10.22 18 181809 941 50422356
Ejection fraction decreased 15.19 10.22 27 181800 18493 50404804
Bradycardia foetal 15.15 10.22 12 181815 379 50422918
White blood cell count decreased 15.13 10.22 312 181515 116410 50306887
Large for dates baby 15.10 10.22 13 181814 462 50422835
Malignant polyp 15.07 10.22 9 181818 177 50423120
Melaena 15.00 10.22 48 181779 26816 50396481
Angioedema 14.94 10.22 77 181750 37599 50385698
Sleep disorder due to a general medical condition 14.93 10.22 4 181823 7367 50415930
Thrombotic thrombocytopenic purpura 14.92 10.22 37 181790 3548 50419749
Neonatal hypoxia 14.91 10.22 13 181814 470 50422827
Pseudobulbar palsy 14.89 10.22 4 181823 6 50423291
Abnormal dreams 14.88 10.22 70 181757 9307 50413990
Floppy infant 14.85 10.22 7 181820 83 50423214
Wrong patient 14.85 10.22 7 181820 83 50423214
Psychotic symptom 14.85 10.22 20 181807 1192 50422105
Bone marrow eosinophilic leukocyte count increased 14.81 10.22 5 181822 22 50423275
Lymphoma 14.81 10.22 8 181819 9593 50413704
Soliloquy 14.81 10.22 9 181818 183 50423114
Constipation 14.79 10.22 532 181295 185176 50238121
Mitral valve incompetence 14.76 10.22 25 181802 17446 50405851
Bronchospasm 14.75 10.22 19 181808 14835 50408462
Asphyxia 14.74 10.22 48 181779 5379 50417918
Proteinuria 14.73 10.22 23 181804 16574 50406723
Haematoma 14.71 10.22 58 181769 30452 50392845
Amimia 14.68 10.22 6 181821 49 50423248
Cardiotoxicity 14.67 10.22 57 181770 6970 50416327
Suspiciousness 14.63 10.22 11 181816 321 50422976
Electrocardiogram ST segment elevation 14.62 10.22 36 181791 3437 50419860
Retrograde amnesia 14.62 10.22 12 181815 399 50422898
Initial insomnia 14.58 10.22 46 181781 5069 50418228
Lactation disorder 14.57 10.22 11 181816 323 50422974
Eczema 14.55 10.22 38 181789 22664 50400633
Dyslipidaemia 14.53 10.22 51 181776 5937 50417360
Accidental death 14.50 10.22 24 181803 1720 50421577
Agitation neonatal 14.46 10.22 13 181814 490 50422807
Carpal tunnel syndrome 14.43 10.22 24 181803 16869 50406428
Central nervous system injury 14.43 10.22 8 181819 136 50423161
Enthesopathy 14.38 10.22 4 181823 7189 50416108
Diabetic complication 14.38 10.22 16 181811 782 50422515
Drowning 14.32 10.22 12 181815 411 50422886
Post procedural complication 14.31 10.22 20 181807 15084 50408213
Complication associated with device 14.29 10.22 19 181808 14636 50408661
Respiratory tract congestion 14.27 10.22 18 181809 14181 50409116
Tearfulness 14.25 10.22 37 181790 3650 50419647
Pre-eclampsia 14.22 10.22 62 181765 7982 50415315
Tongue paralysis 14.22 10.22 9 181818 197 50423100
Gastric ulcer 14.16 10.22 35 181792 21270 50402027
Bundle branch block 14.15 10.22 16 181811 796 50422501
Hypoaesthesia oral 14.15 10.22 76 181751 10652 50412645
Haematuria 14.14 10.22 46 181781 25567 50397730
Dissociative amnesia 14.13 10.22 5 181822 26 50423271
Tricuspid valve incompetence 14.12 10.22 15 181812 12755 50410542
Red blood cell count decreased 14.07 10.22 68 181759 33767 50389530
Skull fracture 14.06 10.22 17 181810 909 50422388
Depression suicidal 14.02 10.22 22 181805 1507 50421790
Rash maculo-papular 13.92 10.22 49 181778 26592 50396705
Diabetic cardiomyopathy 13.90 10.22 3 181824 0 50423297
Hypothermia neonatal 13.90 10.22 3 181824 0 50423297
Erotomanic delusion 13.90 10.22 3 181824 0 50423297
Buccoglossal syndrome 13.90 10.22 3 181824 0 50423297
Micrographia 13.90 10.22 3 181824 0 50423297
Breast enlargement 13.87 10.22 21 181806 1394 50421903
Fall 13.86 10.22 1390 180437 333542 50089755
Spinal compression fracture 13.84 10.22 15 181812 12641 50410656
Genital labial adhesions 13.83 10.22 5 181822 28 50423269
Allergic hepatitis 13.83 10.22 5 181822 28 50423269
Immobilisation prolonged 13.82 10.22 7 181820 98 50423199
Therapeutic response changed 13.81 10.22 16 181811 817 50422480
Chronic obstructive pulmonary disease 13.80 10.22 124 181703 53311 50369986
Colitis ischaemic 13.76 10.22 69 181758 9414 50413883
Autonomic nervous system imbalance 13.72 10.22 28 181799 2357 50420940
Hyperinsulinaemia 13.70 10.22 7 181820 100 50423197
Nail disorder 13.69 10.22 9 181818 9699 50413598
Dysphoria 13.67 10.22 43 181784 4731 50418566
Anhedonia 13.61 10.22 69 181758 9455 50413842
Facial spasm 13.61 10.22 14 181813 625 50422672
Diabetic hyperosmolar coma 13.60 10.22 11 181816 358 50422939
Breast discharge 13.60 10.22 16 181811 831 50422466
Leukopenia neonatal 13.54 10.22 5 181822 30 50423267
Ovarian germ cell cancer stage II 13.54 10.22 5 181822 30 50423267
Electroconvulsive therapy 13.54 10.22 6 181821 61 50423236
Patella fracture 13.54 10.22 24 181803 1818 50421479
Reflexes abnormal 13.53 10.22 13 181814 534 50422763
Lack of spontaneous speech 13.50 10.22 8 181819 155 50423142
Pulse absent 13.50 10.22 43 181784 4763 50418534
Confabulation 13.47 10.22 10 181817 286 50423011
Hypoaesthesia 13.46 10.22 351 181476 126906 50296391
Defect conduction intraventricular 13.46 10.22 7 181820 104 50423193
Electroencephalogram abnormal 13.41 10.22 35 181792 3464 50419833
Congestive cardiomyopathy 13.40 10.22 47 181780 5471 50417826
Respiratory disorder 13.37 10.22 62 181765 31125 50392172
Duplicate therapy error 13.37 10.22 6 181821 63 50423234
Hypothyroidism 13.31 10.22 184 181643 33941 50389356
Brain hypoxia 13.31 10.22 12 181815 454 50422843
Pancreatic carcinoma 13.31 10.22 3 181824 6211 50417086
Neurological examination abnormal 13.28 10.22 9 181818 222 50423075
Acute myocardial infarction 13.27 10.22 57 181770 29216 50394081
Hepatic cirrhosis 13.22 10.22 27 181800 17550 50405747
Limbic encephalitis 13.21 10.22 9 181818 224 50423073
Panic disorder 13.21 10.22 27 181800 2276 50421021
Drug diversion 13.20 10.22 15 181812 750 50422547
Psychotic disorder due to a general medical condition 13.18 10.22 9 181818 225 50423072
Intervertebral disc protrusion 13.17 10.22 34 181793 20359 50402938
Upper limb fracture 13.15 10.22 23 181804 15850 50407447
Anal sphincter atony 13.14 10.22 9 181818 226 50423071
Impaired self-care 13.11 10.22 23 181804 1728 50421569
Chronic sinusitis 13.09 10.22 3 181824 6142 50417155
Infective pulmonary exacerbation of cystic fibrosis 13.09 10.22 6 181821 7903 50415394
Encopresis 13.05 10.22 7 181820 111 50423186
Acute generalised exanthematous pustulosis 13.00 10.22 8 181819 8930 50414367
Skin infection 12.97 10.22 15 181812 12276 50411021
Amylase increased 12.97 10.22 46 181781 5384 50417913
Fear of injection 12.96 10.22 3 181824 6100 50417197
Dopamine dysregulation syndrome 12.93 10.22 8 181819 168 50423129
Bronchial aspiration procedure 12.89 10.22 8 181819 169 50423128
Jealous delusion 12.89 10.22 5 181822 35 50423262
Muscle contractions involuntary 12.80 10.22 24 181803 1898 50421399
Hygroma colli 12.79 10.22 4 181823 13 50423284
Injection site haemorrhage 12.73 10.22 37 181790 21309 50401988
Oesophageal food impaction 12.69 10.22 8 181819 174 50423123
Blood pressure systolic increased 12.66 10.22 75 181752 35374 50387923
Drug reaction with eosinophilia and systemic symptoms 12.65 10.22 157 181670 28267 50395030
Agitated depression 12.62 10.22 7 181820 119 50423178
Female sexual dysfunction 12.54 10.22 5 181822 38 50423259
Spinal fracture 12.51 10.22 23 181804 15550 50407747
On and off phenomenon 12.51 10.22 20 181807 1392 50421905
Bladder prolapse 12.46 10.22 23 181804 1798 50421499
Dysmetropsia 12.45 10.22 6 181821 75 50423222
Poriomania 12.45 10.22 6 181821 75 50423222
Troponin increased 12.45 10.22 60 181767 8058 50415239
Pathological fracture 12.45 10.22 6 181821 7676 50415621
Pulmonary oedema 12.45 10.22 114 181713 48824 50374473
Blood sodium increased 12.43 10.22 27 181800 2375 50420922
Insulin resistance 12.42 10.22 14 181813 694 50422603
Sleep talking 12.32 10.22 16 181811 920 50422377
Neuralgia 12.25 10.22 39 181788 21824 50401473
Tooth abscess 12.21 10.22 17 181810 12843 50410454
Electrocardiogram change 12.20 10.22 13 181814 605 50422692
Flight of ideas 12.19 10.22 10 181817 332 50422965
Cardiopulmonary failure 12.18 10.22 33 181794 3340 50419957
Refusal of examination 12.17 10.22 6 181821 79 50423218
Hypernatraemia 12.17 10.22 50 181777 6271 50417026
Asterixis 12.14 10.22 18 181809 1173 50422124
Splenic injury 12.11 10.22 8 181819 189 50423108
Burnout syndrome 12.11 10.22 8 181819 189 50423108
Blood osmolarity decreased 12.04 10.22 15 181812 827 50422470
Ketoacidosis 12.01 10.22 36 181791 3859 50419438
Oscillopsia 11.98 10.22 7 181820 132 50423165
Cellulitis orbital 11.96 10.22 11 181816 427 50422870
Neonatal behavioural syndrome 11.91 10.22 5 181822 44 50423253
Lymphadenopathy 11.89 10.22 71 181756 33428 50389869
Pyroglutamic acidosis 11.86 10.22 11 181816 432 50422865
Rectal prolapse 11.85 10.22 22 181805 1727 50421570
Multiple sclerosis relapse 11.85 10.22 98 181729 42866 50380431
Angle closure glaucoma 11.85 10.22 24 181803 2010 50421287
Electrolyte substitution therapy 11.83 10.22 3 181824 3 50423294
Congenital emphysema 11.83 10.22 3 181824 3 50423294
Exaggerated startle response 11.83 10.22 3 181824 3 50423294
Postoperative wound infection 11.76 10.22 8 181819 8467 50414830
Immunosuppression 11.73 10.22 6 181821 7420 50415877
Muscle strength abnormal 11.72 10.22 5 181822 46 50423251
Cyst 11.68 10.22 16 181811 12171 50411126
Pseudomonas infection 11.68 10.22 10 181817 9420 50413877
Acinetobacter bacteraemia 11.66 10.22 6 181821 87 50423210
Encephalopathy 11.66 10.22 178 181649 33533 50389764
Accommodation disorder 11.63 10.22 10 181817 355 50422942
Infantile apnoea 11.61 10.22 15 181812 858 50422439
Diffuse large B-cell lymphoma 11.60 10.22 3 181824 5659 50417638
Compulsions 11.58 10.22 8 181819 204 50423093
Respiratory alkalosis 11.56 10.22 27 181800 2492 50420805
Hiatus hernia 11.53 10.22 31 181796 18313 50404984
Swelling face 11.51 10.22 127 181700 52468 50370829
Libido decreased 11.49 10.22 26 181801 2350 50420947
Lactate pyruvate ratio increased 11.48 10.22 6 181821 90 50423207
Kidney duplex 11.44 10.22 5 181822 49 50423248
Lethargy 11.43 10.22 245 181582 49187 50374110
Duodenal ulcer 11.43 10.22 5 181822 6770 50416527
Nerve injury 11.43 10.22 8 181819 8342 50414955
Hangover 11.39 10.22 19 181808 1370 50421927
Stoma site erythema 11.37 10.22 15 181812 876 50422421
Taste disorder 11.36 10.22 8 181819 8316 50414981
Trismus 11.34 10.22 32 181795 3316 50419981
Somatic delusion 11.34 10.22 12 181815 554 50422743
Arthritis infective 11.32 10.22 3 181824 5566 50417731
Freezing phenomenon 11.31 10.22 16 181811 999 50422298
Blood sodium decreased 11.29 10.22 121 181706 21026 50402271
Delusional disorder, unspecified type 11.26 10.22 10 181817 371 50422926
Cataract 11.26 10.22 112 181715 47188 50376109
Wheezing 11.25 10.22 156 181671 61891 50361406
Rotator cuff syndrome 11.22 10.22 15 181812 11529 50411768
Spinal disorder 11.22 10.22 8 181819 8262 50415035
Ventricular septal defect 11.21 10.22 36 181791 4005 50419292
Metabolic alkalosis 11.17 10.22 28 181799 2703 50420594
Immune reconstitution inflammatory syndrome 11.16 10.22 3 181824 5513 50417784
Hypoaldosteronism 11.15 10.22 7 181820 151 50423146
Diet refusal 11.14 10.22 12 181815 565 50422732
Faecal vomiting 11.14 10.22 12 181815 565 50422732
Rebound psychosis 11.12 10.22 4 181823 22 50423275
Housebound 11.11 10.22 8 181819 218 50423079
Tooth disorder 11.09 10.22 47 181780 24181 50399116
Tremor neonatal 11.09 10.22 6 181821 97 50423200
Caesarean section 11.08 10.22 95 181732 15544 50407753
Sluggishness 11.07 10.22 38 181789 4375 50418922
Intentional product use issue 11.06 10.22 202 181625 76716 50346581
Withdrawal catatonia 11.02 10.22 5 181822 54 50423243
Amphetamines positive 10.99 10.22 7 181820 155 50423142
Parkinsonian rest tremor 10.98 10.22 6 181821 99 50423198
Therapy cessation 10.98 10.22 52 181775 25959 50397338
Foetal chromosome abnormality 10.97 10.22 4 181823 23 50423274
Blood creatinine increased 10.96 10.22 200 181627 75960 50347337
Device issue 10.93 10.22 36 181791 19936 50403361
Unintentional medical device removal 10.91 10.22 3 181824 5432 50417865
Peripheral sensory neuropathy 10.91 10.22 5 181822 6586 50416711
Lymphoedema 10.91 10.22 10 181817 9112 50414185
Laryngitis 10.89 10.22 14 181813 10942 50412355
Blood folate decreased 10.87 10.22 12 181815 581 50422716
Conduction disorder 10.87 10.22 18 181809 1290 50422007
Kussmaul respiration 10.86 10.22 8 181819 226 50423071
Escherichia infection 10.86 10.22 14 181813 10927 50412370
Cholecystitis acute 10.84 10.22 6 181821 7100 50416197
Rash erythematous 10.79 10.22 77 181750 34775 50388522
Skin disorder 10.76 10.22 47 181780 23983 50399314
Gestational hypertension 10.76 10.22 24 181803 2149 50421148
Periorbital swelling 10.76 10.22 22 181805 1855 50421442
Accelerated hypertension 10.75 10.22 10 181817 394 50422903
Ideas of reference 10.72 10.22 6 181821 104 50423193
Ultrasound abdomen abnormal 10.70 10.22 5 181822 58 50423239
Suicide threat 10.70 10.22 4 181823 25 50423272
Protrusion tongue 10.67 10.22 9 181818 311 50422986
Mass 10.64 10.22 17 181810 12140 50411157
Blood citric acid increased 10.63 10.22 5 181822 59 50423238
Pulmonary haemorrhage 10.63 10.22 5 181822 6487 50416810
Wound healing normal 10.62 10.22 3 181824 6 50423291
Atrophy of globe 10.62 10.22 3 181824 6 50423291
Crush injury 10.62 10.22 3 181824 6 50423291
Fibula agenesis 10.62 10.22 3 181824 6 50423291
Macroprolactinaemia 10.62 10.22 3 181824 6 50423291
Compulsive shopping 10.60 10.22 13 181814 705 50422592
Hypervigilance 10.57 10.22 9 181818 315 50422982
Cardiac death 10.57 10.22 11 181816 498 50422799
Obsessive thoughts 10.57 10.22 11 181816 498 50422799
Stoma site odour 10.56 10.22 4 181823 26 50423271
Breast discomfort 10.56 10.22 10 181817 403 50422894
Grip strength decreased 10.56 10.22 17 181810 12104 50411193
Haemorrhage 10.56 10.22 132 181695 53309 50369988
Enteritis 10.54 10.22 6 181821 6989 50416308
Eye pruritus 10.53 10.22 18 181809 12516 50410781
Therapy non-responder 10.47 10.22 125 181702 50897 50372400
Product dispensing error 10.41 10.22 61 181766 8830 50414467
Blood iron decreased 10.40 10.22 16 181811 11599 50411698
Therapeutic response decreased 10.36 10.22 114 181713 47117 50376180
Blood magnesium decreased 10.35 10.22 15 181812 11145 50412152
Posterior reversible encephalopathy syndrome 10.34 10.22 24 181803 14904 50408393
Groin pain 10.33 10.22 10 181817 8881 50414416
Skin haemorrhage 10.33 10.22 6 181821 6912 50416385
Somnolence neonatal 10.32 10.22 6 181821 112 50423185
Delusional disorder, erotomanic type 10.31 10.22 4 181823 28 50423269
Metabolic encephalopathy 10.25 10.22 41 181786 5080 50418217
Oral herpes 10.25 10.22 39 181788 20686 50402611
Influenza like illness 10.23 10.22 145 181682 57314 50365983

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1706.40 11.50 1995 122330 88251 29361951
Neuroleptic malignant syndrome 1509.80 11.50 905 123420 15243 29434959
Toxicity to various agents 1336.38 11.50 2513 121812 171148 29279054
Suicide attempt 1195.23 11.50 1054 123271 33056 29417146
Sopor 1004.11 11.50 606 123719 10328 29439874
Drug interaction 903.13 11.50 2319 122006 195066 29255136
Intentional overdose 787.11 11.50 888 123437 37640 29412562
Overdose 731.54 11.50 1249 123076 78570 29371632
Drug abuse 679.91 11.50 1210 123115 78673 29371529
Sedation 668.15 11.50 567 123758 16838 29433364
Psychotic disorder 620.37 11.50 582 123743 19772 29430430
Depression 613.68 11.50 1201 123124 83946 29366256
Agitation 594.75 11.50 894 123431 50410 29399792
Somnolence 562.74 11.50 1228 123097 92727 29357475
Aggression 561.40 11.50 719 123606 34822 29415380
Extrapyramidal disorder 532.75 11.50 408 123917 10423 29439779
Tardive dyskinesia 517.92 11.50 305 124020 4953 29445249
Dyskinesia 489.28 11.50 508 123817 19553 29430649
Priapism 475.60 11.50 273 124052 4215 29445987
Dystonia 474.57 11.50 365 123960 9384 29440818
Coma 450.69 11.50 683 123642 38767 29411435
Hallucination 426.68 11.50 713 123612 43999 29406203
Intentional self-injury 421.85 11.50 378 123947 12083 29438119
Diarrhoea 419.56 11.50 470 123855 332228 29117974
Delusion 383.17 11.50 342 123983 10874 29439328
Depressed level of consciousness 382.06 11.50 611 123714 36331 29413871
Akathisia 378.51 11.50 275 124050 6467 29443735
Electrocardiogram QT prolonged 337.67 11.50 571 123754 35566 29414636
Paranoia 337.05 11.50 301 124024 9576 29440626
Dyspnoea 311.97 11.50 562 123763 326170 29124032
Suicidal ideation 300.07 11.50 530 123795 34186 29416016
Muscle rigidity 296.05 11.50 274 124051 9137 29441065
Diabetes mellitus 291.45 11.50 566 123759 39265 29410937
Catatonia 289.63 11.50 199 124126 4269 29445933
Mania 279.85 11.50 256 124069 8407 29441795
Restlessness 273.70 11.50 398 123927 21747 29428455
Febrile neutropenia 257.70 11.50 76 124249 112164 29338038
Hallucination, auditory 250.28 11.50 252 124073 9341 29440861
Parkinsonism 240.81 11.50 218 124107 7060 29443142
Oculogyric crisis 238.86 11.50 116 124209 1245 29448957
Serotonin syndrome 235.96 11.50 328 123997 17184 29433018
Abnormal behaviour 228.76 11.50 375 123950 22752 29427450
Bradyphrenia 221.01 11.50 165 124160 4049 29446153
Delirium 220.75 11.50 502 123823 38895 29411307
Pneumonia 217.53 11.50 660 123665 319512 29130690
Intentional product misuse 216.09 11.50 461 123864 34200 29416002
Arthralgia 215.82 11.50 163 124162 139454 29310748
Schizophrenia 213.99 11.50 195 124130 6370 29443832
Confusional state 208.04 11.50 1074 123251 126803 29323399
Fatigue 207.49 11.50 664 123661 316157 29134045
Blood creatine phosphokinase increased 203.89 11.50 496 123829 40148 29410054
Anaemia 201.89 11.50 334 123991 200617 29249585
Nausea 200.16 11.50 591 123734 288664 29161538
Rash 199.65 11.50 306 124019 189513 29260689
Poisoning deliberate 198.18 11.50 176 124149 5555 29444647
Obsessive-compulsive disorder 196.14 11.50 159 124166 4417 29445785
Foetal exposure during pregnancy 190.23 11.50 432 123893 33435 29416767
Drug withdrawal syndrome neonatal 187.18 11.50 137 124188 3258 29446944
Malignant neoplasm progression 186.77 11.50 41 124284 73818 29376384
Psychomotor hyperactivity 184.20 11.50 199 124126 8014 29442188
Altered state of consciousness 174.82 11.50 306 124019 19583 29430619
Blood prolactin abnormal 171.39 11.50 80 124245 780 29449422
Poisoning 166.85 11.50 208 124117 9785 29440417
Weight increased 164.25 11.50 698 123627 75969 29374233
Disease progression 163.14 11.50 70 124255 81846 29368356
Atrial fibrillation 162.33 11.50 124 124201 105522 29344680
Tachycardia 157.24 11.50 662 123663 71748 29378454
Rhabdomyolysis 156.22 11.50 586 123739 60222 29389980
Euphoric mood 154.68 11.50 142 124183 4683 29445519
Tremor 149.45 11.50 659 123666 72879 29377323
Cough 149.40 11.50 188 124137 126539 29323663
Cardiac failure congestive 148.46 11.50 68 124257 76513 29373689
Hyperprolactinaemia 147.36 11.50 82 124243 1188 29449014
Emotional poverty 146.92 11.50 60 124265 409 29449793
Bradykinesia 139.82 11.50 116 124209 3331 29446871
Antipsychotic drug level below therapeutic 137.66 11.50 92 124233 1882 29448320
Neuropathy peripheral 136.23 11.50 64 124261 70963 29379239
Sexual dysfunction 134.12 11.50 143 124182 5671 29444531
Acute kidney injury 132.77 11.50 619 123706 264648 29185554
Disinhibition 132.09 11.50 100 124225 2507 29447695
Sepsis 130.64 11.50 251 124074 142431 29307771
Pyrexia 128.12 11.50 699 123626 286923 29163279
Anxiety 127.71 11.50 701 123624 84664 29365538
Speech disorder 127.63 11.50 296 124029 23220 29426982
Pruritus 126.91 11.50 184 124141 116665 29333537
Anosognosia 126.58 11.50 64 124261 754 29449448
Pain 125.83 11.50 340 123985 171092 29279110
Restless legs syndrome 125.71 11.50 151 124174 6833 29443369
Hyperreflexia 122.37 11.50 98 124227 2674 29447528
Type 2 diabetes mellitus 122.01 11.50 211 124114 13370 29436832
Apathy 122.01 11.50 140 124185 6031 29444171
Hallucination, visual 121.68 11.50 223 124102 14792 29435410
Social avoidant behaviour 119.32 11.50 99 124226 2843 29447359
Joint swelling 118.66 11.50 31 124294 49599 29400603
Hypomania 118.17 11.50 87 124238 2088 29448114
Asthenia 118.12 11.50 485 123840 214765 29235437
Haemoglobin decreased 115.39 11.50 173 124152 108202 29342000
Diabetic coma 114.80 11.50 59 124266 721 29449481
Irritability 112.81 11.50 272 124053 21880 29428322
Interstitial lung disease 112.24 11.50 51 124274 57667 29392535
Bipolar disorder 111.56 11.50 100 124225 3195 29447007
Thrombocytopenia 110.92 11.50 252 124073 134571 29315631
Disturbance in social behaviour 110.76 11.50 76 124249 1626 29448576
Pain in extremity 108.43 11.50 186 124139 110247 29339955
Hyperkalaemia 107.81 11.50 62 124263 61330 29388872
Psychiatric decompensation 107.06 11.50 71 124254 1433 29448769
Decreased appetite 105.30 11.50 290 124035 145052 29305150
Pleural effusion 104.65 11.50 89 124236 71819 29378383
Infusion related reaction 103.80 11.50 28 124297 43858 29406344
Bezoar 103.64 11.50 56 124269 763 29449439
Metabolic syndrome 103.56 11.50 69 124256 1404 29448798
Cognitive disorder 101.39 11.50 271 124054 23228 29426974
Prescribed overdose 101.39 11.50 152 124173 8531 29441671
Respiratory disorder neonatal 100.78 11.50 67 124258 1358 29448844
Back pain 100.65 11.50 172 124153 102112 29348090
Loss of personal independence in daily activities 100.44 11.50 284 124041 25156 29425046
Platelet count decreased 100.30 11.50 179 124146 104493 29345709
Headache 97.94 11.50 388 123937 173619 29276583
Respiratory arrest 97.74 11.50 284 124041 25549 29424653
Persecutory delusion 97.30 11.50 77 124248 2064 29448138
Gastrointestinal haemorrhage 96.80 11.50 115 124210 79418 29370784
Drug hypersensitivity 95.52 11.50 88 124237 68318 29381884
Therapeutic product effect variable 95.10 11.50 72 124253 1805 29448397
Pancytopenia 94.21 11.50 127 124198 83041 29367161
Psychotic symptom 94.05 11.50 64 124261 1350 29448852
Withdrawal syndrome 93.84 11.50 167 124158 10825 29439377
Infection 93.39 11.50 111 124214 76640 29373562
Urticaria 90.68 11.50 59 124266 54601 29395601
Insomnia 89.30 11.50 659 123666 88102 29362100
Dysarthria 88.74 11.50 309 124016 30602 29419600
Stomatitis 87.16 11.50 24 124301 37089 29413113
Blood prolactin increased 87.06 11.50 63 124262 1471 29448731
Oedema peripheral 85.58 11.50 193 124132 103364 29346838
Rheumatoid arthritis 85.08 11.50 16 124309 32136 29418066
Miosis 84.80 11.50 134 124191 7875 29442327
Selective eating disorder 84.72 11.50 64 124261 1599 29448603
Suicidal behaviour 84.24 11.50 59 124266 1306 29448896
Increased appetite 83.78 11.50 115 124210 5949 29444253
Obesity 83.11 11.50 149 124176 9714 29440488
Hypertonia neonatal 82.17 11.50 38 124287 362 29449840
Sleep disorder 81.81 11.50 257 124068 24129 29426073
Epistaxis 81.52 11.50 59 124266 51645 29398557
Drug withdrawal syndrome 81.24 11.50 211 124114 17773 29432429
Mydriasis 80.48 11.50 113 124212 5972 29444230
Salivary hypersecretion 79.89 11.50 125 124200 7284 29442918
Myocardial infarction 79.89 11.50 220 124105 110076 29340126
Anger 79.86 11.50 155 124170 10735 29439467
Nasopharyngitis 78.38 11.50 81 124244 59584 29390618
Plasma cell myeloma 78.29 11.50 29 124296 37086 29413116
Schizoaffective disorder 76.40 11.50 51 124274 1041 29449161
Bruxism 76.29 11.50 59 124266 1528 29448674
Mental disorder 75.08 11.50 167 124158 12738 29437464
Metabolic disorder 75.03 11.50 85 124240 3610 29446592
Cogwheel rigidity 75.02 11.50 53 124272 1190 29449012
Drug screen positive 74.75 11.50 86 124239 3715 29446487
Mental impairment 74.36 11.50 136 124189 9005 29441197
Ascites 73.32 11.50 31 124294 36588 29413614
Coronary artery disease 72.88 11.50 48 124277 44142 29406060
Akinesia 72.58 11.50 63 124262 1927 29448275
Seizure 72.35 11.50 652 123673 92471 29357731
Stupor 71.40 11.50 72 124253 2672 29447530
Suspected suicide 70.85 11.50 86 124239 3934 29446268
Agitation neonatal 70.72 11.50 48 124277 1008 29449194
Hyperthermia 70.11 11.50 135 124190 9295 29440907
Pneumonitis 69.98 11.50 16 124309 28028 29422174
Posture abnormal 69.72 11.50 61 124264 1886 29448316
Herpes zoster 69.51 11.50 20 124305 30032 29420170
Dementia 69.10 11.50 152 124173 11506 29438696
Disorientation 68.83 11.50 276 124049 29239 29420963
Pneumonia aspiration 68.41 11.50 321 124004 36416 29413786
Loss of consciousness 68.39 11.50 539 123786 73517 29376685
Psychomotor retardation 68.29 11.50 73 124252 2903 29447299
Acute myocardial infarction 67.98 11.50 62 124263 48376 29401826
Dysphoria 67.89 11.50 62 124263 2030 29448172
Neonatal behavioural syndrome 67.69 11.50 24 124301 104 29450098
Sinusitis 67.31 11.50 30 124295 34320 29415882
Sedation complication 66.78 11.50 50 124275 1232 29448970
Drug dependence 65.73 11.50 216 124109 20765 29429437
Hypertriglyceridaemia 65.65 11.50 115 124210 7360 29442842
Renal failure 65.04 11.50 267 124058 118332 29331870
Visceral congestion 65.02 11.50 35 124290 473 29449729
Cytomegalovirus infection 64.84 11.50 10 124315 23205 29426997
Neonatal respiratory distress syndrome 64.71 11.50 80 124245 3730 29446472
Mucosal inflammation 64.46 11.50 26 124299 31569 29418633
Anaphylactic reaction 64.43 11.50 18 124307 27555 29422647
On and off phenomenon 64.26 11.50 58 124267 1870 29448332
Coma scale abnormal 64.07 11.50 76 124249 3393 29446809
Homicidal ideation 63.44 11.50 65 124260 2459 29447743
Thrombosis 62.94 11.50 53 124272 42992 29407210
Treatment noncompliance 62.57 11.50 234 124091 23993 29426209
Dyspnoea exertional 62.42 11.50 38 124287 36452 29413750
Hyperkinesia 61.12 11.50 52 124273 1547 29448655
Abdominal pain 61.11 11.50 327 123998 135030 29315172
Myocarditis 59.53 11.50 138 124187 10818 29439384
Depressed mood 59.51 11.50 178 124147 16270 29433932
Depression suicidal 59.13 11.50 47 124278 1268 29448934
Chills 58.78 11.50 133 124192 71167 29379035
Faecaloma 58.52 11.50 80 124245 4122 29446080
Influenza 58.30 11.50 54 124271 41827 29408375
Sinus tachycardia 58.28 11.50 167 124158 14902 29435300
Tearfulness 58.07 11.50 51 124274 1585 29448617
Prescription drug used without a prescription 57.34 11.50 46 124279 1258 29448944
Hypotonia neonatal 57.25 11.50 45 124280 1194 29449008
Cardio-respiratory arrest 56.85 11.50 386 123939 50215 29399987
Cardiac failure 56.74 11.50 159 124166 79128 29371074
Renal impairment 56.09 11.50 166 124159 81167 29369035
Clonus 55.75 11.50 59 124266 2319 29447883
Loss of libido 55.67 11.50 58 124267 2238 29447964
Colitis 55.64 11.50 31 124294 31217 29418985
Blood triglycerides increased 55.34 11.50 148 124177 12686 29437516
Antipsychotic drug level above therapeutic 55.26 11.50 42 124283 1059 29449143
Pneumocystis jirovecii pneumonia 55.07 11.50 4 124321 16775 29433427
Major depression 54.90 11.50 74 124251 3761 29446441
Unresponsive to stimuli 54.67 11.50 230 124095 24896 29425306
Small for dates baby 54.22 11.50 71 124254 3508 29446694
Logorrhoea 54.05 11.50 57 124268 2231 29447971
Wrong product administered 53.87 11.50 80 124245 4451 29445751
Vomiting 53.33 11.50 603 123722 211657 29238545
Malaise 53.05 11.50 423 123902 159179 29291023
Colitis ischaemic 52.99 11.50 91 124234 5732 29444470
Basal cell carcinoma 52.83 11.50 5 124320 16905 29433297
Depressive symptom 52.07 11.50 49 124276 1668 29448534
Sleep-related eating disorder 52.07 11.50 25 124300 261 29449941
Delusional disorder, persecutory type 51.95 11.50 24 124301 228 29449974
Poor quality sleep 51.88 11.50 102 124223 7131 29443071
Productive cough 51.48 11.50 34 124291 31225 29418977
Disturbance in attention 51.28 11.50 202 124123 21222 29428980
Somnambulism 51.18 11.50 61 124264 2737 29447465
Torticollis 51.09 11.50 40 124285 1055 29449147
Weight decreased 51.06 11.50 398 123927 150507 29299695
Hypothermia 50.89 11.50 117 124208 9122 29441080
Cellulitis 50.87 11.50 71 124254 45769 29404433
Blood pressure increased 50.62 11.50 151 124174 73652 29376550
Neoplasm progression 49.80 11.50 9 124316 18603 29431599
Brugada syndrome 49.67 11.50 33 124292 668 29449534
Personality change 49.65 11.50 78 124247 4560 29445642
Hypokinesia 48.80 11.50 102 124223 7452 29442750
Arthritis 48.78 11.50 22 124303 24997 29425205
Osteonecrosis of jaw 48.73 11.50 6 124319 16504 29433698
Slow speech 48.33 11.50 36 124289 880 29449322
Myoclonus 48.12 11.50 144 124181 13165 29437037
Haemorrhage 47.86 11.50 72 124253 45000 29405202
Diabetic ketoacidosis 47.27 11.50 162 124163 15911 29434291
Multiple organ dysfunction syndrome 47.08 11.50 124 124201 62992 29387210
Chronic obstructive pulmonary disease 46.89 11.50 62 124263 40893 29409309
Sexually inappropriate behaviour 46.76 11.50 26 124299 376 29449826
Hypersensitivity 46.65 11.50 95 124230 52808 29397394
Upper gastrointestinal haemorrhage 46.42 11.50 17 124308 21897 29428305
Chest discomfort 46.41 11.50 76 124249 45907 29404295
Erythema 46.08 11.50 163 124162 75443 29374759
Epilepsy 45.92 11.50 176 124149 18256 29431946
Aspiration 45.52 11.50 119 124206 10061 29440141
Trichoglossia 45.51 11.50 17 124308 88 29450114
Peripheral swelling 45.46 11.50 128 124197 63611 29386591
Derealisation 45.29 11.50 29 124296 550 29449652
Medication error 45.24 11.50 193 124132 21018 29429184
Arthropathy 45.18 11.50 17 124308 21537 29428665
Oppositional defiant disorder 45.05 11.50 28 124297 503 29449699
Cerebrovascular accident 44.78 11.50 169 124156 76742 29373460
Affect lability 44.73 11.50 63 124262 3339 29446863
Diet refusal 44.68 11.50 23 124302 282 29449920
Urinary incontinence 44.07 11.50 161 124164 16320 29433882
Excessive eye blinking 44.03 11.50 26 124299 424 29449778
Tension 44.03 11.50 47 124278 1866 29448336
Electrocardiogram abnormal 44.00 11.50 96 124229 7226 29442976
Thinking abnormal 43.98 11.50 79 124246 5157 29445045
Psychomotor skills impaired 43.79 11.50 55 124270 2606 29447596
Bone marrow failure 43.67 11.50 31 124294 27418 29422784
Oedema 43.64 11.50 64 124261 40419 29409783
Lung disorder 43.63 11.50 38 124287 30324 29419878
Granulocytopenia 43.56 11.50 85 124240 5909 29444293
Abulia 43.49 11.50 27 124298 484 29449718
Multiple drug therapy 43.41 11.50 24 124301 343 29449859
Atrial septal defect 43.08 11.50 91 124234 6698 29443504
Urinary retention 42.41 11.50 254 124071 31644 29418558
Hepatic failure 42.26 11.50 42 124283 31470 29418732
Acute myeloid leukaemia 42.05 11.50 9 124316 16504 29433698
Suspiciousness 41.68 11.50 22 124303 285 29449917
Vein of Galen aneurysmal malformation 41.66 11.50 11 124314 11 29450191
Oropharyngeal spasm 41.62 11.50 18 124307 144 29450058
Blood creatinine increased 40.97 11.50 201 124124 84901 29365301
Product substitution issue 40.79 11.50 107 124218 9065 29441137
Otospondylomegaepiphyseal dysplasia 40.61 11.50 16 124309 98 29450104
Abdominal discomfort 40.58 11.50 88 124237 47815 29402387
Stoma site erythema 40.52 11.50 28 124297 606 29449596
Dyslipidaemia 40.51 11.50 83 124242 5978 29444224
Gambling disorder 40.38 11.50 41 124284 1534 29448668
Temperature regulation disorder 40.11 11.50 27 124298 559 29449643
Accidental death 40.10 11.50 47 124278 2071 29448131
Hypoaesthesia 39.91 11.50 105 124220 53362 29396840
Chest pain 39.89 11.50 291 124034 111682 29338520
Myelosuppression 39.89 11.50 3 124322 12224 29437978
Judgement impaired 39.86 11.50 27 124298 565 29449637
Palmar-plantar erythrodysaesthesia syndrome 39.78 11.50 7 124318 14752 29435450
Decreased eye contact 39.70 11.50 25 124300 460 29449742
Embolism venous 39.56 11.50 38 124287 1328 29448874
Dehydration 39.55 11.50 301 124024 114447 29335755
Stereotypy 39.54 11.50 28 124297 631 29449571
Myelodysplastic syndrome 39.07 11.50 13 124312 17781 29432421
Asthma 39.00 11.50 51 124274 33798 29416404
Psychosexual disorder 38.61 11.50 15 124310 88 29450114
Malignant catatonia 38.47 11.50 19 124306 212 29449990
Flushing 38.47 11.50 39 124286 28953 29421249
Inflammation 38.41 11.50 24 124301 22704 29427498
Poverty of speech 38.40 11.50 19 124306 213 29449989
Freezing phenomenon 38.22 11.50 36 124289 1227 29448975
Vasoplegia syndrome 38.20 11.50 39 124286 1469 29448733
Muscle twitching 38.14 11.50 96 124229 7930 29442272
Pleurothotonus 38.13 11.50 33 124292 1005 29449197
Septic shock 38.03 11.50 135 124190 62425 29387777
International normalised ratio increased 38.01 11.50 81 124244 44291 29405911
Grimacing 37.57 11.50 20 124305 264 29449938
Stoma site discharge 37.48 11.50 31 124294 886 29449316
Trismus 37.39 11.50 48 124277 2325 29447877
Haemoptysis 37.32 11.50 44 124281 30506 29419696
Electrocardiogram QT interval abnormal 37.09 11.50 14 124311 75 29450127
Tic 36.89 11.50 42 124283 1793 29448409
Pulmonary fibrosis 36.72 11.50 10 124315 15572 29434630
Prostate cancer 36.61 11.50 32 124293 25495 29424707
Full blood count decreased 36.33 11.50 11 124314 15981 29434221
Large for dates baby 36.29 11.50 30 124295 857 29449345
Chronic kidney disease 35.99 11.50 61 124264 36355 29413847
Personality disorder 35.89 11.50 33 124292 1090 29449112
Sudden cardiac death 35.63 11.50 55 124270 3167 29447035
Distributive shock 35.55 11.50 31 124294 954 29449248
Diverticulitis 35.41 11.50 15 124310 17689 29432513
Bronchopulmonary aspergillosis 35.20 11.50 5 124320 12339 29437863
Dystonic tremor 35.20 11.50 17 124308 180 29450022
Accidental overdose 35.17 11.50 157 124168 17436 29432766
Libido increased 35.08 11.50 27 124298 694 29449508
Device related infection 35.08 11.50 11 124314 15625 29434577
Impulsive behaviour 34.95 11.50 42 124283 1901 29448301
Hyperammonaemia 34.88 11.50 75 124250 5588 29444614
Neonatal seizure 34.82 11.50 23 124302 461 29449741
Synovitis 34.61 11.50 3 124322 10887 29439315
Skin ulcer 34.55 11.50 18 124307 18822 29431380
Mood altered 34.43 11.50 93 124232 8018 29442184
Blood bilirubin increased 34.21 11.50 56 124269 33837 29416365
Substance abuse 34.17 11.50 83 124242 6704 29443498
Drooling 34.01 11.50 52 124273 2969 29447233
Musculoskeletal pain 34.00 11.50 43 124282 28910 29421292
Antipsychotic drug level increased 33.97 11.50 54 124271 3189 29447013
Device dislocation 33.88 11.50 65 124260 4462 29445740
Brachial plexopathy 33.84 11.50 12 124313 52 29450150
Prostatic specific antigen increased 33.78 11.50 6 124319 12558 29437644
Hangover 33.76 11.50 30 124295 947 29449255
Hypertonia 33.74 11.50 59 124266 3770 29446432
Fall 33.69 11.50 979 123346 176199 29274003
Psoriatic arthropathy 33.56 11.50 10 124315 14681 29435521
Dementia with Lewy bodies 33.49 11.50 25 124300 613 29449589
Haematuria 33.46 11.50 86 124239 44053 29406149
Incoherent 33.43 11.50 61 124264 4031 29446171
Swelling 33.15 11.50 61 124264 35222 29414980
Alcoholism 33.10 11.50 48 124277 2613 29447589
Haemophagocytic lymphohistiocytosis 33.10 11.50 3 124322 10501 29439701
Upper respiratory tract infection 32.76 11.50 40 124285 27309 29422893
Death 32.70 11.50 1144 123181 340940 29109262
Coordination abnormal 32.67 11.50 84 124241 7030 29443172
Rash pruritic 32.11 11.50 28 124297 22335 29427867
Haematochezia 32.10 11.50 67 124258 36916 29413286
Neonatal toxicity 32.06 11.50 10 124315 26 29450176
Feeling jittery 32.04 11.50 56 124269 3577 29446625
Psychiatric symptom 31.96 11.50 52 124273 3132 29447070
Staring 31.95 11.50 34 124291 1345 29448857
Oral discharge 31.85 11.50 14 124311 117 29450085
Lymphadenopathy 31.77 11.50 35 124290 25014 29425188
Hyperosmolar state 31.72 11.50 20 124305 369 29449833
Nephrolithiasis 31.47 11.50 36 124289 25298 29424904
Anticonvulsant drug level above therapeutic 31.27 11.50 23 124302 551 29449651
Reduced facial expression 31.25 11.50 25 124300 681 29449521
Gout 31.24 11.50 16 124309 16895 29433307
Flight of ideas 31.08 11.50 19 124306 331 29449871
Blood cholesterol increased 31.04 11.50 139 124186 15456 29434746
Tachyphrenia 31.01 11.50 31 124294 1138 29449064
Bronchitis 31.00 11.50 68 124257 36800 29413402
Nightmare 30.92 11.50 112 124213 11305 29438897
Wheezing 30.76 11.50 58 124267 33182 29417020
Myalgia 30.56 11.50 184 124141 73835 29376367
Exposure via ingestion 30.52 11.50 40 124285 1978 29448224
Overweight 30.39 11.50 34 124291 1424 29448778
Pruritus genital 30.24 11.50 22 124303 518 29449684
Bipolar I disorder 30.07 11.50 25 124300 720 29449482
Cytokine release syndrome 29.84 11.50 9 124316 13110 29437092
Fluid retention 29.79 11.50 33 124292 23527 29426675
Resting tremor 29.79 11.50 23 124302 594 29449608
Injection site pain 29.69 11.50 57 124268 32389 29417813
Muscular weakness 29.60 11.50 147 124178 61905 29388297
Acute psychosis 29.58 11.50 36 124289 1651 29448551
Nonspecific reaction 29.58 11.50 30 124295 1121 29449081
Hypocalcaemia 29.52 11.50 26 124299 20639 29429563
Skin lesion 29.51 11.50 21 124304 18551 29431651
Hyperammonaemic encephalopathy 29.41 11.50 39 124286 1951 29448251
Gastrointestinal disorder 29.38 11.50 47 124278 28659 29421543
Squamous cell carcinoma of skin 29.12 11.50 3 124322 9483 29440719
COVID-19 29.00 11.50 68 124257 35946 29414256
Hypoglycaemia neonatal 28.96 11.50 36 124289 1688 29448514
Leukopenia 28.90 11.50 357 123968 54846 29395356
Screaming 28.87 11.50 31 124294 1239 29448963
Withdrawal arrhythmia 28.83 11.50 10 124315 40 29450162
Hypomagnesaemia 28.76 11.50 19 124306 17449 29432753
Dacryostenosis congenital 28.64 11.50 10 124315 41 29450161
Blister 28.49 11.50 25 124300 19881 29430321
Dependence 28.48 11.50 28 124297 1007 29449195
Cholestasis 28.44 11.50 34 124291 23428 29426774
Troponin increased 28.27 11.50 94 124231 9089 29441113
Neonatal tachypnoea 28.13 11.50 14 124311 159 29450043
Oropharyngeal pain 28.08 11.50 50 124275 29235 29420967
Transplant rejection 28.06 11.50 3 124322 9209 29440993
Delusional disorder, unspecified type 27.91 11.50 23 124302 654 29449548
Pyromania 27.55 11.50 10 124315 47 29450155
Pseudomonas infection 27.45 11.50 6 124319 10846 29439356
Tumour lysis syndrome 27.39 11.50 12 124313 13872 29436330
Affective disorder 27.33 11.50 48 124277 3078 29447124
Rebound effect 27.28 11.50 38 124287 1993 29448209
Patent ductus arteriosus 27.27 11.50 48 124277 3083 29447119
Illusion 27.18 11.50 23 124302 679 29449523
Melaena 26.62 11.50 57 124268 31119 29419083
Galactorrhoea 26.60 11.50 18 124307 376 29449826
Hypervolaemia 26.39 11.50 21 124304 17524 29432678
Excessive masturbation 26.33 11.50 11 124314 80 29450122
Alcohol abuse 26.25 11.50 57 124268 4276 29445926
Hypersomnia 26.22 11.50 102 124223 10652 29439550
Hypoacusis 26.12 11.50 14 124311 14409 29435793
Atrial flutter 25.88 11.50 13 124312 13881 29436321
Incontinence 25.83 11.50 62 124263 4970 29445232
Neoplasm malignant 25.78 11.50 20 124305 16905 29433297
Cholecystitis 25.59 11.50 4 124321 9193 29441009
Meconium aspiration syndrome 25.38 11.50 9 124316 39 29450163
Illness anxiety disorder 25.36 11.50 13 124312 158 29450044
Fungal infection 25.20 11.50 13 124312 13672 29436530
Encephalopathy neonatal 25.20 11.50 9 124316 40 29450162
Blood urea increased 25.19 11.50 50 124275 28062 29422140
Stoma site infection 25.12 11.50 22 124303 681 29449521
Coagulopathy 25.02 11.50 23 124302 17884 29432318
Feelings of worthlessness 25.01 11.50 15 124310 252 29449950
Rectal haemorrhage 24.91 11.50 69 124256 34480 29415722
Abdominal distension 24.73 11.50 104 124221 45807 29404395
Drug dispensed to wrong patient 24.60 11.50 15 124310 260 29449942
Impulse-control disorder 24.56 11.50 28 124297 1197 29449005
Type 1 diabetes mellitus 24.47 11.50 50 124275 3594 29446608
Blepharospasm 24.42 11.50 26 124299 1029 29449173
Intentional product use issue 24.32 11.50 94 124231 42404 29407798
Paraesthesia 24.30 11.50 130 124195 53715 29396487
Respiratory failure 24.29 11.50 276 124049 96855 29353347
Bone pain 24.27 11.50 25 124300 18427 29431775
Urine alcohol test positive 24.11 11.50 8 124317 27 29450175
Penile haemorrhage 23.82 11.50 20 124305 584 29449618
Acute coronary syndrome 23.77 11.50 11 124314 12314 29437888
Rash maculo-papular 23.71 11.50 41 124284 24248 29425954
Respiratory depression 23.60 11.50 116 124209 13407 29436795
Angioedema 23.56 11.50 63 124262 31852 29418350
Psoriasis 23.50 11.50 64 124261 32163 29418039
Pancreatitis 23.45 11.50 235 124090 34279 29415923
Gastrointestinal necrosis 23.37 11.50 44 124281 2978 29447224
Choreoathetosis 23.37 11.50 25 124300 995 29449207
Salivary gland calculus 23.28 11.50 9 124316 52 29450150
Peritonitis 23.24 11.50 17 124308 14807 29435395
Refusal of treatment by patient 23.20 11.50 57 124268 4637 29445565
Brain injury 23.19 11.50 63 124262 5449 29444753
Hyperdynamic left ventricle 23.15 11.50 11 124314 112 29450090
Lung neoplasm malignant 23.12 11.50 16 124309 14341 29435861
Stoma site hypergranulation 23.11 11.50 12 124313 150 29450052
Subgaleal haematoma 23.07 11.50 8 124317 32 29450170
Interleukin level increased 23.02 11.50 10 124315 81 29450121
Treatment failure 22.92 11.50 79 124246 36860 29413342
Cerebral infarction 22.88 11.50 43 124282 24632 29425570
Blunted affect 22.87 11.50 15 124310 297 29449905
Tremor neonatal 22.85 11.50 16 124309 354 29449848
Penis injury 22.85 11.50 14 124311 245 29449957
Stoma site inflammation 22.80 11.50 17 124308 416 29449786
Autonomic nervous system imbalance 22.77 11.50 38 124287 2338 29447864
Bacteraemia 22.76 11.50 21 124304 16302 29433900
Dyspepsia 22.59 11.50 59 124266 30066 29420136
Slow response to stimuli 22.56 11.50 21 124304 705 29449497
Feeling guilty 22.52 11.50 15 124310 305 29449897
Cleft lip and palate 22.39 11.50 15 124310 308 29449894
pH body fluid decreased 22.38 11.50 5 124320 0 29450202
Drug diversion 22.34 11.50 22 124303 793 29449409
Contraindication to medical treatment 22.22 11.50 17 124308 433 29449769
Maternal drugs affecting foetus 22.21 11.50 50 124275 3843 29446359
Ketoacidosis 22.19 11.50 48 124277 3591 29446611
Osteoarthritis 22.19 11.50 26 124299 18077 29432125
Renal disorder 22.19 11.50 38 124287 22557 29427645
Amnesia 22.09 11.50 167 124158 22476 29427726
Opisthotonus 22.09 11.50 17 124308 437 29449765
Angina unstable 22.06 11.50 9 124316 10856 29439346
Acute respiratory failure 21.94 11.50 49 124276 26353 29423849
Verbal abuse 21.80 11.50 12 124313 170 29450032
Erectile dysfunction 21.79 11.50 140 124185 17869 29432333
Heart rate decreased 21.73 11.50 45 124280 24867 29425335
Pulmonary mass 21.67 11.50 9 124316 10739 29439463
Cholelithiasis 21.64 11.50 28 124297 18644 29431558
Encephalitis toxic 21.53 11.50 14 124311 273 29449929
Self-medication 21.38 11.50 35 124290 2119 29448083
Laboratory test abnormal 21.36 11.50 27 124298 18158 29432044
Postural orthostatic tachycardia syndrome 21.32 11.50 8 124317 42 29450160
Angina pectoris 21.30 11.50 54 124271 27796 29422406
Rhinorrhoea 21.30 11.50 36 124289 21483 29428719
Schizophreniform disorder 21.25 11.50 9 124316 68 29450134
Mood swings 21.24 11.50 73 124252 7178 29443024
Newborn persistent pulmonary hypertension 21.03 11.50 10 124315 102 29450100
Dysphonia 21.02 11.50 30 124295 19166 29431036
Enuresis 20.87 11.50 34 124291 2050 29448152
Pyramidal tract syndrome 20.85 11.50 12 124313 186 29450016
Blood pressure systolic increased 20.85 11.50 24 124301 16821 29433381
Tooth disorder 20.85 11.50 7 124318 9522 29440680
Myoclonic epilepsy 20.77 11.50 23 124302 952 29449250
Lactic acidosis 20.64 11.50 62 124263 30185 29420017
Staphylococcal infection 20.63 11.50 59 124266 29181 29421021
Epidermolysis bullosa 20.61 11.50 10 124315 107 29450095
Compartment syndrome 20.60 11.50 37 124288 2415 29447787
Osteonecrosis 20.56 11.50 16 124309 13503 29436699
Congestive cardiomyopathy 20.53 11.50 68 124257 6562 29443640
Dizziness 20.51 11.50 624 123701 189060 29261142
Hepatotoxicity 20.50 11.50 27 124298 17840 29432362
Renal tubular necrosis 20.46 11.50 18 124307 14297 29435905
Immune reconstitution inflammatory syndrome 20.39 11.50 4 124321 7798 29442404
Polydipsia 20.33 11.50 45 124280 3420 29446782
Panic attack 20.32 11.50 79 124246 8247 29441955
Bacterial parotitis 20.32 11.50 6 124319 12 29450190
Congenital cerebrovascular anomaly 20.32 11.50 6 124319 12 29450190
Localised infection 20.20 11.50 17 124308 13799 29436403
Intentional medical device removal by patient 20.20 11.50 12 124313 198 29450004
Necrotising colitis 20.14 11.50 23 124302 985 29449217
Stoma site pain 20.09 11.50 17 124308 502 29449700
Gaze palsy 20.04 11.50 26 124299 1273 29448929
Muscle spasms 19.99 11.50 176 124149 64906 29385296
Pulmonary haemorrhage 19.96 11.50 7 124318 9263 29440939
Hypospadias 19.93 11.50 41 124284 2961 29447241
Brain hypoxia 19.91 11.50 14 124311 312 29449890
Osteomyelitis 19.88 11.50 17 124308 13692 29436510
End stage renal disease 19.88 11.50 4 124321 7660 29442542
Renal injury 19.84 11.50 9 124316 10193 29440009
Sudden death 19.81 11.50 114 124211 13996 29436206
Troponin I increased 19.78 11.50 32 124293 1918 29448284
Orthostatic hypertension 19.68 11.50 12 124313 208 29449994
Painful erection 19.63 11.50 12 124313 209 29449993
Hallucinations, mixed 19.53 11.50 36 124289 2397 29447805
Parkinsonian gait 19.50 11.50 16 124309 452 29449750
Pulmonary hypertension 19.48 11.50 30 124295 18578 29431624
Eye movement disorder 19.47 11.50 46 124279 3650 29446552
Cholangitis 19.41 11.50 4 124321 7533 29442669
Injection site erythema 19.41 11.50 18 124307 13938 29436264
Parkinsonian rest tremor 19.40 11.50 10 124315 123 29450079
Impaired self-care 19.22 11.50 22 124303 945 29449257
Water intoxication 19.21 11.50 15 124310 394 29449808
Abdominal pain upper 19.15 11.50 164 124161 60829 29389373
Junctional ectopic tachycardia 19.13 11.50 6 124319 16 29450186
Hepatic encephalopathy 19.11 11.50 16 124309 13019 29437183
Posturing 19.06 11.50 16 124309 467 29449735
Proteinuria 19.05 11.50 23 124302 15781 29434421
Talipes 18.99 11.50 30 124295 1762 29448440
Haemorrhage intracranial 18.79 11.50 20 124305 14522 29435680
Enteritis 18.79 11.50 3 124322 6788 29443414
IVth nerve disorder 18.61 11.50 6 124319 18 29450184
Haemangioma congenital 18.61 11.50 16 124309 483 29449719
Hepatitis 18.59 11.50 37 124288 20746 29429456
Squamous cell carcinoma 18.49 11.50 10 124315 10241 29439961
Ataxia 18.46 11.50 100 124225 12003 29438199
Oral pain 18.43 11.50 8 124317 9299 29440903
Device kink 18.42 11.50 14 124311 353 29449849
Swelling face 18.40 11.50 36 124289 20314 29429888
Influenza like illness 18.29 11.50 48 124277 24422 29425780
Hypercalcaemia 18.29 11.50 16 124309 12743 29437459
Liver function test increased 18.16 11.50 14 124311 11871 29438331
Flashback 18.14 11.50 10 124315 142 29450060
Waxy flexibility 18.03 11.50 9 124316 103 29450099
Tubulointerstitial nephritis 17.94 11.50 29 124296 17614 29432588
Self-injurious ideation 17.89 11.50 27 124298 1524 29448678
Acoustic stimulation tests abnormal 17.88 11.50 8 124317 70 29450132
Drug resistance 17.88 11.50 40 124285 21500 29428702
Perseveration 17.88 11.50 9 124316 105 29450097
Ventricular tachycardia 17.87 11.50 43 124282 22531 29427671
Hyperhidrosis 17.73 11.50 375 123950 64165 29386037
Status epilepticus 17.71 11.50 91 124234 10703 29439499
Anxiolytic therapy 17.71 11.50 6 124319 22 29450180
Phaeochromocytoma malignant 17.69 11.50 8 124317 72 29450130
Rebound psychosis 17.67 11.50 10 124315 150 29450052
Motor dysfunction 17.63 11.50 60 124265 5870 29444332
Retrograde ejaculation 17.62 11.50 13 124312 313 29449889
Myocardial ischaemia 17.60 11.50 25 124300 16003 29434199
Eosinophilic pleural effusion 17.58 11.50 11 124314 200 29450002
Choking 17.58 11.50 50 124275 4441 29445761
Cardiac failure chronic 17.58 11.50 3 124322 6464 29443738
Condition aggravated 17.50 11.50 767 123558 145528 29304674
Prescribed underdose 17.50 11.50 72 124253 7714 29442488
Inappropriate affect 17.39 11.50 16 124309 529 29449673
Metastases to bone 17.36 11.50 10 124315 9888 29440314
False positive investigation result 17.35 11.50 12 124313 260 29449942
Intercepted medication error 17.33 11.50 15 124310 457 29449745
Dysgeusia 17.32 11.50 44 124281 22630 29427572
Camptocormia 17.27 11.50 10 124315 157 29450045
Clostridium difficile colitis 17.27 11.50 18 124307 13194 29437008
Skin exfoliation 17.25 11.50 44 124281 22601 29427601
Cerebral amyloid angiopathy 17.23 11.50 9 124316 114 29450088
Gastrointestinal hypomotility 17.21 11.50 20 124305 873 29449329
Cryptorchism 17.21 11.50 30 124295 1912 29448290
Lymphoma 17.13 11.50 10 124315 9818 29440384
Borderline personality disorder 17.13 11.50 13 124312 327 29449875
Laryngospasm 17.12 11.50 24 124301 1266 29448936
Kidney duplex 17.11 11.50 14 124311 394 29449808
Unevaluable event 17.09 11.50 66 124259 29785 29420417
Panic disorder 17.09 11.50 23 124302 1167 29449035
Conduction disorder 17.06 11.50 29 124296 1811 29448391
Hepatitis cholestatic 17.06 11.50 4 124321 6889 29443313
Apraxia 16.97 11.50 23 124302 1175 29449027
Nervousness 16.97 11.50 93 124232 11213 29438989
Gynaecomastia 16.93 11.50 74 124251 8143 29442059
Generalised tonic-clonic seizure 16.93 11.50 138 124187 19001 29431201
Behaviour disorder 16.92 11.50 43 124282 3573 29446629
Blood urine present 16.90 11.50 10 124315 9745 29440457
Wrong patient 16.89 11.50 9 124316 119 29450083
Alcohol interaction 16.88 11.50 36 124289 2667 29447535
Neck pain 16.86 11.50 41 124284 21406 29428796
Attention deficit hyperactivity disorder 16.80 11.50 32 124293 2185 29448017
Metastases to lung 16.79 11.50 6 124319 7849 29442353
Patient isolation 16.74 11.50 6 124319 27 29450175
Bladder cancer 16.69 11.50 11 124314 10116 29440086
Substance use 16.66 11.50 15 124310 482 29449720
Myoglobin blood increased 16.63 11.50 30 124295 1965 29448237
Paradoxical drug reaction 16.54 11.50 36 124289 2705 29447497
Erection increased 16.53 11.50 15 124310 487 29449715
Alcohol use 16.52 11.50 39 124286 3093 29447109
Anaphylactic shock 16.51 11.50 19 124306 13317 29436885
Convulsive threshold lowered 16.50 11.50 15 124310 488 29449714
Ejection fraction decreased 16.50 11.50 26 124299 15952 29434250
Vascular stenosis 16.47 11.50 10 124315 172 29450030
Inappropriate antidiuretic hormone secretion 16.46 11.50 90 124235 10842 29439360
Sluggishness 16.44 11.50 38 124287 2973 29447229
Hypoxia 16.43 11.50 124 124201 47255 29402947
Hyperphagia 16.36 11.50 23 124302 1217 29448985
Penoscrotal fusion 16.31 11.50 5 124320 12 29450190
Embedded device 16.29 11.50 11 124314 229 29449973
Lower respiratory tract infection 16.22 11.50 57 124268 26445 29423757
Mental status changes 16.22 11.50 221 124104 34706 29415496
Pulmonary oedema 16.21 11.50 109 124216 42626 29407576
Lip swelling 16.11 11.50 17 124308 12393 29437809
Colon cancer 16.11 11.50 6 124319 7649 29442553
Compulsions 16.07 11.50 10 124315 180 29450022
Delirium febrile 16.07 11.50 6 124319 31 29450171
Drug therapy enhancement 16.07 11.50 6 124319 31 29450171
Negativism 16.00 11.50 13 124312 362 29449840
Lymphopenia 15.99 11.50 20 124305 13513 29436689
Antisocial behaviour 15.98 11.50 12 124313 297 29449905
Hypoalbuminaemia 15.92 11.50 12 124313 10293 29439909
Full blood count abnormal 15.91 11.50 24 124301 14989 29435213
Blood creatine phosphokinase decreased 15.89 11.50 14 124311 437 29449765
Psychotic disorder due to a general medical condition 15.87 11.50 7 124318 59 29450143
Hyperglycaemic hyperosmolar nonketotic syndrome 15.86 11.50 21 124304 1049 29449153
Memory impairment 15.82 11.50 228 124097 36242 29413960
Bundle branch block right 15.80 11.50 63 124262 6654 29443548
Laryngeal dyspnoea 15.77 11.50 8 124317 95 29450107
Polymerase chain reaction 15.77 11.50 8 124317 95 29450107
Dry skin 15.74 11.50 48 124277 23259 29426943
Infantile apnoea 15.70 11.50 19 124306 866 29449336
Postoperative respiratory failure 15.69 11.50 8 124317 96 29450106
Leukopenia neonatal 15.68 11.50 4 124321 3 29450199
Skin cancer 15.66 11.50 8 124317 8460 29441742
Transposition of the great vessels 15.65 11.50 14 124311 446 29449756
Carbon monoxide poisoning 15.62 11.50 8 124317 97 29450105
Obsessive thoughts 15.60 11.50 16 124309 606 29449596
Multiple cardiac defects 15.58 11.50 7 124318 62 29450140
Obstructive airways disorder 15.57 11.50 14 124311 11002 29439200
Abscess 15.56 11.50 11 124314 9751 29440451
Hot flush 15.54 11.50 24 124301 14846 29435356
Finnegan score increased 15.51 11.50 5 124320 15 29450187
Faeces discoloured 15.49 11.50 20 124305 13331 29436871
Hepatic cancer 15.48 11.50 4 124321 6452 29443750
Somatic symptom disorder 15.48 11.50 15 124310 530 29449672
Mutism 15.42 11.50 17 124308 700 29449502
Congenital cystic kidney disease 15.36 11.50 13 124312 384 29449818
Communication disorder 15.35 11.50 32 124293 2333 29447869
Psychotic behaviour 15.34 11.50 16 124309 618 29449584
Drug level increased 15.31 11.50 133 124192 18654 29431548
Hernia 15.30 11.50 8 124317 8350 29441852
Injection site pruritus 15.28 11.50 3 124322 5846 29444356
Frequent bowel movements 15.27 11.50 10 124315 9229 29440973
Discomfort 15.27 11.50 24 124301 14739 29435463
Sexual abuse 15.23 11.50 9 124316 147 29450055
Appendicitis 15.21 11.50 9 124316 8770 29441432
Anamnestic reaction 15.20 11.50 6 124319 37 29450165
Jealous delusion 15.16 11.50 10 124315 200 29450002
Neuralgia 15.15 11.50 14 124311 10860 29439342
Intermittent explosive disorder 15.15 11.50 4 124321 4 29450198
Anomaly of external ear congenital 15.13 11.50 8 124317 104 29450098
Hyperglycaemia 15.13 11.50 215 124110 34072 29416130
Knee arthroplasty 15.13 11.50 3 124322 5806 29444396
Optic discs blurred 15.11 11.50 7 124318 67 29450135
Clostridium difficile infection 15.08 11.50 28 124297 16113 29434089
Tongue spasm 15.06 11.50 6 124319 38 29450164
Pain in jaw 15.05 11.50 16 124309 11625 29438577
Stoma site extravasation 15.02 11.50 7 124318 68 29450134
Incorrect route of product administration 14.99 11.50 87 124238 10714 29439488
Homicide 14.98 11.50 19 124306 909 29449293
Muscle hypertrophy 14.93 11.50 6 124319 39 29450163
Crying 14.92 11.50 53 124272 5298 29444904
Yawning 14.89 11.50 14 124311 476 29449726
Toxic epidermal necrolysis 14.83 11.50 34 124291 18119 29432083
Delusional perception 14.76 11.50 9 124316 156 29450046
Emotional disorder 14.76 11.50 50 124275 4881 29445321
Diabetes insipidus 14.72 11.50 32 124293 2402 29447800
Cerebral disorder 14.71 11.50 31 124294 2277 29447925
Visual acuity reduced 14.62 11.50 25 124300 14851 29435351
Language disorder 14.50 11.50 28 124297 1931 29448271
Brachial plexus injury 14.50 11.50 7 124318 74 29450128
Feminisation acquired 14.44 11.50 6 124319 43 29450159
Antisocial personality disorder 14.42 11.50 5 124320 20 29450182
Volvulus 14.42 11.50 21 124304 1148 29449054
Enterocolitis 14.41 11.50 5 124320 6661 29443541
Metabolic encephalopathy 14.39 11.50 41 124284 3646 29446556
Iron deficiency anaemia 14.35 11.50 10 124315 8932 29441270
Ageusia 14.34 11.50 10 124315 8928 29441274
Maternal exposure during pregnancy 14.33 11.50 44 124281 4079 29446123
Acute generalised exanthematous pustulosis 14.30 11.50 3 124322 5580 29444622
Postmortem blood drug level increased 14.29 11.50 10 124315 221 29449981
Toxic skin eruption 14.27 11.50 12 124313 9745 29440457
Shoulder deformity 14.26 11.50 4 124321 6 29450196
Sexual activity increased 14.23 11.50 5 124320 21 29450181
Respiratory distress 14.21 11.50 78 124247 32028 29418174
Flat affect 14.05 11.50 17 124308 775 29449427
Breast inflammation 14.04 11.50 5 124320 22 29450180
Distractibility 14.02 11.50 11 124314 291 29449911
Therapy interrupted 13.97 11.50 9 124316 8377 29441825
Post procedural haemorrhage 13.97 11.50 7 124318 7484 29442718
Blood pressure diastolic decreased 13.96 11.50 6 124319 7016 29443186
Colitis ulcerative 13.94 11.50 20 124305 12749 29437453
Movement disorder 13.91 11.50 82 124243 10155 29440047
Hypophosphataemia 13.90 11.50 8 124317 7916 29442286
Large intestine polyp 13.87 11.50 5 124320 6504 29443698
Infant irritability 13.86 11.50 5 124320 23 29450179
Facial spasm 13.86 11.50 9 124316 175 29450027
Pulmonary arterial hypertension 13.83 11.50 7 124318 7442 29442760
Haemolysis 13.74 11.50 6 124319 6950 29443252
Product storage error 13.73 11.50 5 124320 6465 29443737
Alcohol poisoning 13.70 11.50 36 124289 3053 29447149
Haematocrit decreased 13.69 11.50 69 124256 28953 29421249
Shock haemorrhagic 13.66 11.50 12 124313 9539 29440663
Urinary tract infection 13.58 11.50 218 124107 72136 29378066
Oral candidiasis 13.57 11.50 15 124310 10707 29439495
Sciatic nerve neuropathy 13.56 11.50 6 124319 51 29450151
Diastolic hypotension 13.53 11.50 5 124320 25 29450177
Delusion of reference 13.53 11.50 5 124320 25 29450177
Blood lactic acid increased 13.50 11.50 54 124271 5712 29444490
Medical device site injury 13.43 11.50 3 124322 0 29450202
Tonic posturing 13.43 11.50 3 124322 0 29450202
Pulmonary alveolar haemorrhage 13.42 11.50 5 124320 6375 29443827
Compulsive shopping 13.42 11.50 12 124313 382 29449820
Parkinson's disease 13.35 11.50 22 124303 1339 29448863
Congenital pulmonary valve atresia 13.27 11.50 6 124319 54 29450148
Injection site swelling 13.27 11.50 12 124313 9405 29440797
Xanthoma 13.24 11.50 7 124318 91 29450111
Shock 13.24 11.50 143 124182 21261 29428941
Neuroleptic-induced deficit syndrome 13.21 11.50 5 124320 27 29450175
Dopamine dysregulation syndrome 13.19 11.50 11 124314 318 29449884
Blood alkaline phosphatase increased 13.13 11.50 68 124257 28338 29421864
Postmortem blood drug level 13.10 11.50 8 124317 139 29450063
Loss of employment 13.08 11.50 13 124312 474 29449728
Hyponatraemic coma 13.06 11.50 5 124320 28 29450174
Flatulence 13.04 11.50 35 124290 17674 29432528
Peritonitis bacterial 13.00 11.50 4 124321 5752 29444450
Divorced 12.94 11.50 4 124321 10 29450192
Somatic delusion 12.91 11.50 7 124318 96 29450106
Binge eating 12.91 11.50 7 124318 96 29450106
Arachnoid cyst 12.90 11.50 9 124316 198 29450004
Subarachnoid haemorrhage 12.90 11.50 13 124312 9679 29440523
Malignant melanoma 12.89 11.50 7 124318 7154 29443048
Eye pain 12.82 11.50 18 124307 11577 29438625
Obsessive-compulsive personality disorder 12.81 11.50 8 124317 145 29450057
Metastases to central nervous system 12.80 11.50 7 124318 7124 29443078
Antipsychotic drug level decreased 12.79 11.50 17 124308 852 29449350
Lymphocyte count decreased 12.79 11.50 40 124285 19231 29430971
Small intestinal obstruction 12.79 11.50 22 124303 13039 29437163
Neurological symptom 12.69 11.50 37 124288 3333 29446869
Fistula 12.68 11.50 3 124322 5136 29445066
Pneumothorax 12.68 11.50 30 124295 15812 29434390
Generalised oedema 12.67 11.50 17 124308 11148 29439054
Mixed dementia 12.67 11.50 10 124315 267 29449935
Drug withdrawal headache 12.66 11.50 4 124321 11 29450191
Injection site haemorrhage 12.66 11.50 10 124315 8376 29441826
Epstein-Barr virus infection 12.66 11.50 6 124319 6623 29443579
Delusion of grandeur 12.59 11.50 12 124313 415 29449787
Gastroenteritis 12.58 11.50 21 124304 12595 29437607
Dysphagia 12.55 11.50 311 124014 54615 29395587
Cyanosis neonatal 12.54 11.50 10 124315 271 29449931
Caesarean section 12.46 11.50 26 124299 1897 29448305
COVID-19 pneumonia 12.41 11.50 13 124312 9509 29440693
Ischaemic enteritis 12.41 11.50 4 124321 12 29450190
Immune thrombocytopenia 12.39 11.50 9 124316 7868 29442334
Congenital hydronephrosis 12.32 11.50 15 124310 688 29449514
Enterococcal infection 12.30 11.50 10 124315 8258 29441944
Eye swelling 12.23 11.50 11 124314 8646 29441556
Electroencephalogram abnormal 12.23 11.50 29 124296 2306 29447896
Respiratory fatigue 12.22 11.50 6 124319 66 29450136
Food refusal 12.21 11.50 8 124317 158 29450044
Foaming at mouth 12.15 11.50 15 124310 698 29449504
Hepatitis B 12.09 11.50 4 124321 5493 29444709
Corneal reflex decreased 12.08 11.50 8 124317 161 29450041
Hostility 12.06 11.50 16 124309 801 29449401
Sciatica 12.01 11.50 3 124322 4951 29445251
Total cholesterol/HDL ratio increased 12.00 11.50 8 124317 163 29450039
Helplessness 11.99 11.50 6 124319 69 29450133
Uveitis 11.95 11.50 5 124320 5942 29444260
Nuchal rigidity 11.95 11.50 12 124313 443 29449759
Transfusion 11.93 11.50 8 124317 7290 29442912
Patient uncooperative 11.92 11.50 11 124314 365 29449837
Selective mutism 11.92 11.50 6 124319 70 29450132
Heart rate abnormal 11.92 11.50 23 124302 1586 29448616
Cor pulmonale acute 11.91 11.50 9 124316 225 29449977
Pressure of speech 11.88 11.50 12 124313 446 29449756
Gastric ulcer haemorrhage 11.87 11.50 3 124322 4911 29445291
Intestinal perforation 11.76 11.50 10 124315 8076 29442126
Exposure via body fluid 11.76 11.50 7 124318 116 29450086
Transient ischaemic attack 11.75 11.50 54 124271 23216 29426986
Tooth avulsion 11.73 11.50 4 124321 15 29450187
Musculoskeletal stiffness 11.73 11.50 222 124103 37236 29412966
Stoma site induration 11.67 11.50 5 124320 39 29450163
Nephrotic syndrome 11.67 11.50 6 124319 6322 29443880
Metastases to liver 11.58 11.50 20 124305 11836 29438366
Oromandibular dystonia 11.58 11.50 12 124313 460 29449742
Tendon rupture 11.56 11.50 6 124319 6289 29443913
Mouth ulceration 11.52 11.50 16 124309 10339 29439863
Suspected suicide attempt 11.50 11.50 7 124318 121 29450081

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5120.46 10.49 5345 253055 219069 64021263
Toxicity to various agents 3973.14 10.49 5987 252413 357526 63882806
Sopor 3249.17 10.49 1812 256588 27849 64212483
Suicide attempt 2805.71 10.49 2303 256097 68704 64171628
Neuroleptic malignant syndrome 2580.15 10.49 1469 256931 23527 64216805
Intentional overdose 2561.23 10.49 2422 255978 87522 64152810
Drug abuse 2513.78 10.49 2868 255532 129506 64110826
Overdose 1846.08 10.49 2706 255694 156860 64083472
Drug interaction 1684.45 10.49 4157 254243 357926 63882406
Intentional self-injury 1507.29 10.49 1108 257292 27936 64212396
Sedation 1368.93 10.49 1214 257186 40248 64200084
Somnolence 1287.20 10.49 2644 255756 201001 64039331
Dystonia 1180.71 10.49 807 257593 18058 64222274
Coma 1158.39 10.49 1585 256815 86030 64154302
Electrocardiogram QT prolonged 1103.11 10.49 1472 256928 77976 64162356
Tardive dyskinesia 1048.91 10.49 577 257823 8601 64231731
Agitation 1044.16 10.49 1515 256885 86852 64153480
Dyskinesia 1009.31 10.49 1002 257398 38386 64201946
Extrapyramidal disorder 951.87 10.49 718 257682 18834 64221498
Depressed level of consciousness 892.68 10.49 1348 257052 80088 64160244
Suicidal ideation 840.56 10.49 1178 257222 65364 64174968
Aggression 781.36 10.49 945 257455 45287 64195045
Psychotic disorder 768.68 10.49 815 257585 33763 64206569
Akathisia 762.23 10.49 510 257890 11000 64229332
Mania 643.76 10.49 529 257871 15757 64224575
Diarrhoea 643.14 10.49 1201 257199 721503 63518829
Serotonin syndrome 634.68 10.49 785 257615 38497 64201835
Muscle rigidity 627.55 10.49 537 257863 16936 64223396
Delusion 617.36 10.49 539 257861 17475 64222857
Parkinsonism 589.45 10.49 477 257923 13896 64226436
Hallucination 585.35 10.49 1048 257352 71740 64168592
Blood prolactin abnormal 555.75 10.49 254 258146 2478 64237854
Poisoning 544.49 10.49 548 257852 21331 64219001
Arthralgia 540.18 10.49 586 257814 441674 63798658
Dyspnoea 518.94 10.49 1340 257060 717334 63522998
Schizophrenia 516.83 10.49 398 258002 10770 64229562
Sexual dysfunction 512.81 10.49 321 258079 6150 64234182
Tachycardia 506.94 10.49 1532 256868 148047 64092285
Gestational diabetes 498.43 10.49 299 258101 5291 64235041
Bradyphrenia 494.89 10.49 362 258038 9044 64231288
Restlessness 463.52 10.49 678 257722 39107 64201225
Depression 443.12 10.49 1676 256724 181615 64058717
Pain 439.42 10.49 981 257419 552530 63687802
Poisoning deliberate 437.81 10.49 391 258009 13067 64227265
Anosognosia 433.82 10.49 216 258184 2589 64237743
Abnormal behaviour 428.46 10.49 598 257802 33024 64207308
Delirium 427.24 10.49 891 257509 68303 64172029
Diabetes mellitus 422.21 10.49 866 257534 65608 64174724
Hallucination, auditory 420.98 10.49 424 257976 16515 64223817
Psychomotor hyperactivity 412.04 10.49 390 258010 14061 64226271
Altered state of consciousness 411.58 10.49 625 257775 37277 64203055
Priapism 411.15 10.49 234 258166 3736 64236596
Febrile neutropenia 410.55 10.49 121 258279 187536 64052796
Confusional state 410.17 10.49 2098 256302 259046 63981286
Rash 398.87 10.49 771 257629 457778 63782554
Joint swelling 398.54 10.49 182 258218 215200 64025132
Paranoia 398.51 10.49 405 257995 15947 64224385
Respiratory arrest 393.16 10.49 737 257663 52248 64188084
Disturbance in social behaviour 391.54 10.49 225 258175 3662 64236670
Intentional product misuse 388.26 10.49 880 257520 71415 64168917
Catatonia 386.78 10.49 287 258113 7333 64232999
Cardio-respiratory arrest 385.58 10.49 1062 257338 97331 64143001
Fatigue 366.96 10.49 1650 256750 747080 63493252
Bezoar 347.69 10.49 172 258228 2031 64238301
Hypomania 337.49 10.49 235 258165 5419 64234913
Oculogyric crisis 330.35 10.49 174 258226 2364 64237968
Bradykinesia 326.08 10.49 244 258156 6316 64234016
Tremor 322.05 10.49 1311 257089 146919 64093413
Metabolic disorder 314.64 10.49 255 258145 7442 64232890
Nausea 306.25 10.49 1872 256528 783928 63456404
Mydriasis 305.44 10.49 341 258059 14971 64225361
Cough 304.57 10.49 462 257938 301686 63938646
Pain in extremity 303.05 10.49 466 257934 302619 63937713
Blood creatine phosphokinase increased 299.17 10.49 699 257701 57859 64182473
Pneumonia 298.40 10.49 1193 257207 558383 63681949
Hyperprolactinaemia 298.05 10.49 192 258208 3873 64236459
Restless legs syndrome 289.25 10.49 350 258050 16766 64223566
Personality change 286.15 10.49 253 258147 8340 64231992
Malignant neoplasm progression 285.88 10.49 53 258347 112818 64127514
Anaemia 278.52 10.49 698 257702 377982 63862350
Disease progression 269.41 10.49 115 258285 141565 64098767
Drug hypersensitivity 268.34 10.49 335 258065 237480 64002852
Nasopharyngitis 266.32 10.49 236 258164 195837 64044495
Sinusitis 265.67 10.49 126 258274 145802 64094530
Pruritus 265.44 10.49 532 257868 311868 63928464
Loss of consciousness 263.33 10.49 1235 257165 147130 64093202
Rheumatoid arthritis 261.26 10.49 168 258232 164126 64076206
Anxiety 260.74 10.49 1543 256857 201106 64039226
Speech disorder 260.40 10.49 590 257810 47851 64192481
Infusion related reaction 256.35 10.49 172 258228 164295 64076037
Metabolic syndrome 255.60 10.49 143 258257 2205 64238127
Seizure 245.91 10.49 1318 257082 165574 64074758
Peripheral swelling 238.68 10.49 292 258108 208861 64031471
Disorientation 238.15 10.49 622 257778 55206 64185126
Headache 238.11 10.49 1202 257198 528265 63712067
Rhabdomyolysis 235.78 10.49 856 257544 90870 64149462
Cardiac failure congestive 235.77 10.49 114 258286 130466 64109866
Sinus tachycardia 231.62 10.49 442 257958 31746 64208586
Irritability 230.02 10.49 476 257924 36270 64204062
Back pain 228.25 10.49 408 257992 249763 63990569
Cardiac arrest 223.76 10.49 1212 257188 152852 64087480
Infection 221.81 10.49 248 258152 184632 64055700
Dysarthria 218.66 10.49 627 257773 58779 64181553
Sepsis 212.52 10.49 373 258027 229968 64010364
Suspected suicide 206.60 10.49 212 258188 8442 64231890
Hypersensitivity 205.99 10.49 292 258108 196160 64044172
Obsessive-compulsive disorder 204.11 10.49 163 258237 4655 64235677
Atrial fibrillation 203.59 10.49 231 258169 170858 64069474
Abdominal discomfort 203.33 10.49 259 258141 182063 64058269
Disturbance in attention 202.91 10.49 484 257916 40590 64199742
Drug withdrawal syndrome 202.54 10.49 411 257989 30880 64209452
Synovitis 202.27 10.49 72 258328 99018 64141314
Bipolar disorder 201.43 10.49 187 258213 6574 64233758
Swelling 200.99 10.49 207 258193 160011 64080321
Urticaria 199.16 10.49 178 258222 147139 64093193
Cogwheel rigidity 197.53 10.49 130 258270 2723 64237609
Stomatitis 197.38 10.49 96 258304 109509 64130823
Galactorrhoea 194.95 10.49 135 258265 3084 64237248
Urinary retention 193.54 10.49 532 257868 48669 64191663
Blood prolactin increased 192.90 10.49 139 258261 3389 64236943
Arthropathy 191.86 10.49 124 258276 120843 64119489
Type 2 diabetes mellitus 189.14 10.49 420 257980 33600 64206732
Exposure during pregnancy 187.15 10.49 710 257690 76965 64163367
Drug intolerance 186.79 10.49 290 258110 187702 64052630
Herpes zoster 182.56 10.49 46 258354 79141 64161191
Neuropathy peripheral 181.63 10.49 124 258276 117401 64122931
Stubbornness 181.50 10.49 62 258338 249 64240083
Miosis 178.06 10.49 242 258158 13024 64227308
Obesity 176.72 10.49 305 258095 20257 64220075
Pyrexia 171.97 10.49 1423 256977 557221 63683111
Anticholinergic syndrome 171.26 10.49 116 258284 2553 64237779
Emotional poverty 166.84 10.49 73 258327 636 64239696
Coma scale abnormal 165.21 10.49 179 258221 7595 64232737
Labour complication 162.52 10.49 41 258359 31 64240301
Haemoglobin decreased 162.25 10.49 336 258064 194727 64045605
Malaise 162.11 10.49 928 257472 395319 63845013
Alopecia 161.36 10.49 259 258141 165431 64074901
Salivary hypersecretion 159.60 10.49 219 258181 11894 64228438
Thinking abnormal 158.44 10.49 213 258187 11343 64228989
Hallucination, visual 157.40 10.49 346 258054 27488 64212844
Hypokinesia 151.66 10.49 253 258147 16343 64223989
Somnambulism 150.86 10.49 141 258259 5000 64235332
Anger 150.62 10.49 245 258155 15496 64224836
Treatment noncompliance 147.63 10.49 446 257954 43036 64197296
Gastrointestinal haemorrhage 147.43 10.49 188 258212 132124 64108208
Psychomotor retardation 146.98 10.49 139 258261 5004 64235328
Derealisation 146.48 10.49 85 258315 1410 64238922
Cognitive disorder 145.68 10.49 519 257881 54568 64185764
Sleep-related eating disorder 143.74 10.49 65 258335 617 64239715
Mucosal inflammation 143.02 10.49 37 258363 62547 64177785
Acute kidney injury 142.37 10.49 1135 257265 448105 63792227
Pneumonia aspiration 142.11 10.49 541 257859 58730 64181602
Interstitial lung disease 142.04 10.49 110 258290 97622 64142710
Platelet count decreased 140.21 10.49 288 258112 167423 64072909
Hyperammonaemic encephalopathy 140.17 10.49 122 258278 3936 64236396
Hyperreflexia 138.81 10.49 157 258243 6991 64233341
Hallucinations, mixed 138.60 10.49 145 258255 5907 64234425
Psychomotor skills impaired 137.68 10.49 118 258282 3727 64236605
Apathy 137.45 10.49 196 258204 11036 64229296
Withdrawal syndrome 136.22 10.49 295 258105 23197 64217135
Persecutory delusion 135.61 10.49 121 258279 4037 64236295
Weight increased 134.44 10.49 1376 257024 211972 64028360
Prescribed overdose 133.89 10.49 269 258131 20062 64220270
Unresponsive to stimuli 132.59 10.49 474 257926 49919 64190413
Erythema 132.51 10.49 351 258049 186719 64053613
Myocardial infarction 131.74 10.49 293 258107 165528 64074804
Diabetic coma 131.67 10.49 72 258328 1059 64239273
Pleurothotonus 131.16 10.49 93 258307 2209 64238123
Influenza 129.79 10.49 141 258259 106390 64133942
Psychiatric decompensation 127.76 10.49 94 258306 2369 64237963
Drug screen positive 127.18 10.49 135 258265 5594 64234738
Arthritis 126.09 10.49 91 258309 83723 64156609
Injection site erythema 125.95 10.49 63 258337 70737 64169595
Pleural effusion 124.93 10.49 196 258204 126363 64113969
Antipsychotic drug level increased 123.36 10.49 126 258274 4989 64235343
Respiratory depression 122.04 10.49 282 258118 23161 64217171
Pancytopenia 120.70 10.49 245 258155 143064 64097268
Euphoric mood 119.96 10.49 140 258260 6451 64233881
Substance abuse 119.42 10.49 166 258234 9126 64231206
Myoclonus 118.71 10.49 291 258109 24827 64215505
Contraindicated product administered 117.25 10.49 156 258244 107673 64132659
Hyperthermia 116.15 10.49 217 258183 15333 64224999
Mood swings 116.09 10.49 232 258168 17236 64223096
Chest discomfort 115.37 10.49 179 258221 115927 64124405
Gastrointestinal disorder 114.62 10.49 114 258286 89595 64150737
Depersonalisation/derealisation disorder 114.20 10.49 75 258325 1565 64238767
Epistaxis 113.97 10.49 135 258265 97996 64142336
Mental disorder 113.11 10.49 295 258105 26150 64214182
Stupor 112.87 10.49 130 258270 5905 64234427
Mood altered 111.97 10.49 217 258183 15762 64224570
Asthenia 111.69 10.49 1136 257264 426908 63813424
Drug dependence 110.56 10.49 339 258061 32973 64207359
Thrombocytopenia 110.26 10.49 491 257909 223310 64017022
Cellulitis 109.67 10.49 128 258272 93529 64146803
Hyperkalaemia 109.25 10.49 147 258253 100982 64139350
Faecaloma 109.24 10.49 163 258237 9565 64230767
Posture abnormal 108.87 10.49 98 258302 3308 64237024
Suicidal behaviour 108.29 10.49 91 258309 2796 64237536
Orthostatic hypertension 107.15 10.49 52 258348 587 64239745
Decreased appetite 106.87 10.49 674 257726 280615 63959717
Hypothermia 105.73 10.49 241 258159 19615 64220717
Mental impairment 104.96 10.49 214 258186 16129 64224203
Embolism venous 104.48 10.49 97 258303 3410 64236922
Skin ulcer 104.38 10.49 24 258376 43950 64196382
Systemic lupus erythematosus 103.38 10.49 95 258305 77517 64162815
Depressed mood 103.00 10.49 380 258020 40632 64199700
Flushing 102.73 10.49 98 258302 78550 64161782
Cytomegalovirus infection 101.95 10.49 14 258386 37185 64203147
Schizoaffective disorder 101.89 10.49 69 258331 1518 64238814
Social avoidant behaviour 100.48 10.49 107 258293 4450 64235882
Ascites 100.41 10.49 62 258338 61939 64178393
Chills 99.89 10.49 254 258146 137010 64103322
Oedema peripheral 99.67 10.49 468 257932 209849 64030483
Injection site pain 99.42 10.49 184 258216 111224 64129108
Treatment failure 98.96 10.49 199 258201 116617 64123715
Abdominal pain 98.91 10.49 789 257611 311586 63928746
Musculoskeletal pain 98.57 10.49 108 258292 81186 64159146
Dyspnoea exertional 98.50 10.49 90 258310 73640 64166692
Diverticulitis 98.03 10.49 18 258382 38600 64201732
Logorrhoea 97.91 10.49 100 258300 3959 64236373
Bipolar I disorder 97.34 10.49 70 258330 1701 64238631
Impaired healing 97.21 10.49 61 258339 60412 64179920
Electrocardiogram QRS complex prolonged 96.88 10.49 150 258250 9094 64231238
Hand deformity 95.93 10.49 67 258333 62704 64177628
Lower respiratory tract infection 95.79 10.49 144 258256 94470 64145862
Drooling 95.17 10.49 112 258288 5207 64235125
Homicidal ideation 94.94 10.49 89 258311 3168 64237164
Feeling of despair 94.38 10.49 80 258320 2488 64237844
Therapeutic product effect decreased 93.92 10.49 201 258199 115150 64125182
Nightmare 93.72 10.49 238 258162 20755 64219577
Myocarditis 93.13 10.49 209 258191 16834 64223498
Coronary artery disease 93.02 10.49 64 258336 60369 64179963
Clonus 92.76 10.49 118 258282 5949 64234383
Plasma cell myeloma 91.44 10.49 35 258365 46040 64194292
Chest pain 91.39 10.49 562 257838 235418 64004914
Fluid retention 90.59 10.49 64 258336 59542 64180790
Pneumocystis jirovecii pneumonia 90.24 10.49 5 258395 27629 64212703
Osteonecrosis of jaw 90.12 10.49 24 258376 39801 64200531
Psychotic symptom 89.86 10.49 72 258328 2066 64238266
Dissociation 89.16 10.49 83 258317 2928 64237404
Productive cough 89.03 10.49 97 258303 73106 64167226
Pemphigus 88.59 10.49 68 258332 60633 64179699
Urinary tract infection 87.39 10.49 556 257844 231040 64009292
Exposure via ingestion 87.35 10.49 103 258297 4799 64235533
Sleep disorder 86.75 10.49 470 257930 59239 64181093
Akinesia 85.67 10.49 82 258318 2997 64237335
Blood triglycerides increased 85.38 10.49 215 258185 18651 64221681
Osteoarthritis 84.98 10.49 77 258323 63259 64177073
Major depression 84.97 10.49 129 258271 7687 64232645
Hyperkinesia 84.84 10.49 75 258325 2471 64237861
Bone marrow failure 84.79 10.49 43 258357 47909 64192423
Basal cell carcinoma 83.59 10.49 12 258388 30826 64209506
Accidental overdose 82.66 10.49 309 258091 33248 64207084
Anaphylactic reaction 82.39 10.49 92 258308 68572 64171760
Bone pain 82.13 10.49 44 258356 47528 64192804
Cardiac failure 81.61 10.49 265 258135 132108 64108224
Colitis 81.54 10.49 69 258331 58605 64181727
Thrombosis 81.15 10.49 98 258302 70544 64169788
Bronchitis 80.84 10.49 199 258201 108544 64131788
Granulocytopenia 79.62 10.49 147 258253 10293 64230039
Aspiration 79.13 10.49 195 258205 16690 64223642
Inflammation 78.89 10.49 87 258313 65213 64175119
Neoplasm progression 78.21 10.49 33 258367 40931 64199401
Gastric pH decreased 77.93 10.49 44 258356 691 64239641
Blood pressure increased 77.65 10.49 391 258009 172161 64068171
Psychiatric symptom 77.55 10.49 110 258290 6163 64234169
Renal failure 77.12 10.49 420 257980 181268 64059064
Disorganised speech 76.76 10.49 59 258341 1591 64238741
Generalised tonic-clonic seizure 76.71 10.49 340 258060 39517 64200815
Disinhibition 76.60 10.49 67 258333 2176 64238156
Palmar-plantar erythrodysaesthesia syndrome 76.31 10.49 12 258388 28807 64211525
Injection site pruritus 76.29 10.49 28 258372 37798 64202534
Affect lability 75.48 10.49 132 258268 8858 64231474
Hypotension 75.45 10.49 2029 256371 378945 63861387
Bruxism 74.49 10.49 82 258318 3542 64236790
Upper respiratory tract infection 74.42 10.49 110 258290 72675 64167657
Torticollis 74.29 10.49 65 258335 2112 64238220
Dementia 74.27 10.49 217 258183 20549 64219783
Impulsive behaviour 74.25 10.49 71 258329 2592 64237740
Slow speech 73.93 10.49 63 258337 1974 64238358
Tic 73.35 10.49 70 258330 2549 64237783
Myelosuppression 72.88 10.49 6 258394 23824 64216508
Depressive symptom 72.81 10.49 90 258310 4406 64235926
Insomnia 72.38 10.49 1154 257246 196682 64043650
Muscle twitching 72.29 10.49 203 258197 18795 64221537
Impulse-control disorder 72.17 10.49 56 258344 1532 64238800
Acute myeloid leukaemia 71.45 10.49 12 258388 27451 64212881
Prescribed underdose 71.02 10.49 195 258205 17820 64222512
Pneumonitis 70.27 10.49 59 258341 50306 64190026
Stereotypy 69.83 10.49 43 258357 799 64239533
Discomfort 69.16 10.49 137 258263 80741 64159591
Glossodynia 68.89 10.49 95 258305 64601 64175731
Weight decreased 68.89 10.49 772 257628 284967 63955365
Injection site swelling 68.86 10.49 40 258360 41313 64199019
Abdominal pain upper 68.69 10.49 415 257985 174615 64065717
Renal impairment 68.40 10.49 293 258107 134724 64105608
Visceral congestion 68.22 10.49 42 258358 780 64239552
Enuresis 67.78 10.49 69 258331 2721 64237611
Oromandibular dystonia 66.63 10.49 43 258357 870 64239462
Nasal congestion 66.18 10.49 85 258315 59573 64180759
Vomiting 66.13 10.49 1692 256708 549425 63690907
Distributive shock 66.03 10.49 57 258343 1818 64238514
Acute myocardial infarction 65.94 10.49 111 258289 69607 64170725
Alcohol abuse 65.85 10.49 89 258311 4763 64235569
Tension 65.65 10.49 79 258321 3761 64236571
Tearfulness 65.38 10.49 87 258313 4586 64235746
Medication error 65.10 10.49 382 258018 49584 64190748
Coma blister 64.45 10.49 27 258373 209 64240123
Amenorrhoea 64.22 10.49 103 258297 6436 64233896
Tachyphrenia 63.99 10.49 56 258344 1820 64238512
Hyperammonaemia 63.97 10.49 130 258270 9774 64230558
Behaviour disorder 63.86 10.49 84 258316 4378 64235954
Panic attack 63.81 10.49 207 258193 20746 64219586
Long QT syndrome 63.36 10.49 90 258310 5049 64235283
Neutropenic sepsis 63.21 10.49 9 258391 23263 64217069
Colitis ischaemic 62.95 10.49 155 258245 13259 64227073
Rhinorrhoea 62.92 10.49 89 258311 59880 64180452
On and off phenomenon 62.48 10.49 63 258337 2456 64237876
Antipsychotic drug level above therapeutic 62.37 10.49 55 258345 1806 64238526
Product substitution issue 62.31 10.49 185 258215 17676 64222656
Acute psychosis 62.20 10.49 76 258324 3676 64236656
Anti-cyclic citrullinated peptide antibody positive 62.13 10.49 64 258336 49498 64190834
Depression suicidal 61.57 10.49 62 258338 2413 64237919
Red blood cell sedimentation rate increased 61.52 10.49 24 258376 31211 64209121
Rash pruritic 61.42 10.49 84 258316 57320 64183012
Antipsychotic drug level below therapeutic 61.28 10.49 42 258358 943 64239389
Hypervolaemia 61.00 10.49 39 258361 38246 64202086
Bronchopulmonary aspergillosis 60.67 10.49 4 258396 19081 64221251
Drug level increased 60.08 10.49 284 258116 33912 64206420
Myalgia 59.69 10.49 381 258019 158236 64082096
Attention deficit hyperactivity disorder 59.24 10.49 64 258336 2706 64237626
Septic shock 58.97 10.49 220 258180 105217 64135115
Mutism 58.17 10.49 55 258345 1979 64238353
Myelodysplastic syndrome 58.06 10.49 19 258381 27560 64212772
Hypersomnia 56.66 10.49 191 258209 19526 64220806
Schizophreniform disorder 56.56 10.49 22 258378 137 64240195
Urinary hesitation 56.42 10.49 70 258330 3440 64236892
Electrocardiogram QRS complex shortened 56.40 10.49 34 258366 607 64239725
Nephrolithiasis 56.37 10.49 55 258345 43628 64196704
Hypertriglyceridaemia 56.36 10.49 133 258267 11072 64229260
Oropharyngeal pain 56.09 10.49 176 258224 88691 64151641
Incontinence 56.06 10.49 139 258261 11942 64228390
Dyspepsia 55.82 10.49 152 258248 80160 64160172
Sleep disorder due to general medical condition, insomnia type 55.47 10.49 18 258382 26252 64214080
Abulia 55.45 10.49 38 258362 853 64239479
Leukopenia 55.34 10.49 635 257765 100607 64139725
Hypotonia 55.22 10.49 132 258268 11080 64229252
Clostridium difficile colitis 55.15 10.49 20 258380 27203 64213129
COVID-19 55.12 10.49 111 258289 65029 64175303
Psoriasis 55.04 10.49 129 258271 71574 64168758
Blister 54.97 10.49 155 258245 80812 64159520
Stoma site discharge 54.96 10.49 49 258351 1633 64238699
Polydipsia 54.87 10.49 90 258310 5731 64234601
Dysphoria 54.32 10.49 77 258323 4311 64236021
Epilepsy 54.26 10.49 272 258128 33259 64207073
Ataxia 54.09 10.49 203 258197 21881 64218451
Aspergillus infection 53.37 10.49 3 258397 16376 64223956
Brugada syndrome 53.36 10.49 40 258360 1038 64239294
Incoherent 52.75 10.49 99 258301 7019 64233313
Cerebrovascular accident 52.52 10.49 329 258071 137254 64103078
Asthma 52.40 10.49 200 258200 95025 64145307
Parkinsonian gait 52.34 10.49 36 258364 813 64239519
Haemophagocytic lymphohistiocytosis 52.32 10.49 5 258395 17604 64222728
Circulatory collapse 52.05 10.49 270 258130 33462 64206870
Osteonecrosis 51.91 10.49 24 258376 28205 64212127
Lung disorder 51.73 10.49 103 258297 60597 64179735
Poverty of speech 51.69 10.49 31 258369 548 64239784
Transplant rejection 51.55 10.49 5 258395 17396 64222936
Urinary incontinence 51.44 10.49 283 258117 35868 64204464
Insurance issue 51.38 10.49 60 258340 2766 64237566
Homicide 51.03 10.49 40 258360 1111 64239221
Increased appetite 50.57 10.49 120 258280 10026 64230306
Drug ineffective 50.43 10.49 2804 255596 837443 63402889
Slow response to stimuli 49.96 10.49 45 258355 1520 64238812
Dry skin 49.73 10.49 80 258320 51081 64189251
Sexually inappropriate behaviour 49.58 10.49 28 258372 440 64239892
Pain in jaw 49.55 10.49 54 258346 40701 64199631
Menstrual disorder 49.17 10.49 64 258336 3301 64237031
Inappropriate affect 49.14 10.49 41 258359 1247 64239085
Localised infection 49.05 10.49 30 258370 30131 64210201
Abnormal weight gain 48.86 10.49 52 258348 2161 64238171
Alcohol poisoning 48.78 10.49 72 258328 4183 64236149
Feeling guilty 48.63 10.49 34 258366 789 64239543
Accidental death 48.55 10.49 67 258333 3658 64236674
Haemoptysis 48.33 10.49 76 258324 48972 64191360
Psychotic behaviour 48.32 10.49 37 258363 992 64239340
Hypertonia 48.16 10.49 89 258311 6236 64234096
Gastrooesophageal reflux disease 48.13 10.49 171 258229 82972 64157360
Hypertension 47.95 10.49 740 257660 258521 63981811
Full blood count abnormal 47.84 10.49 30 258370 29727 64210605
Rectal haemorrhage 47.61 10.49 111 258289 61706 64178626
Breast cancer 47.39 10.49 29 258371 29119 64211213
Electrocardiogram abnormal 47.37 10.49 140 258260 13341 64226991
Torsade de pointes 47.10 10.49 165 258235 17198 64223134
Electrocardiogram QT interval abnormal 46.91 10.49 23 258377 266 64240066
Full blood count decreased 46.76 10.49 16 258384 22566 64217766
Language disorder 46.62 10.49 56 258344 2661 64237671
Bundle branch block right 46.44 10.49 117 258283 10152 64230180
Negativism 46.32 10.49 32 258368 728 64239604
Cytokine release syndrome 46.29 10.49 13 258387 20816 64219516
Suspiciousness 46.03 10.49 29 258371 562 64239770
Oppositional defiant disorder 45.95 10.49 27 258373 459 64239873
Anaemia of pregnancy 45.84 10.49 15 258385 51 64240281
Status epilepticus 45.68 10.49 190 258210 21473 64218859
Injection site bruising 45.56 10.49 47 258353 36326 64204006
Alcohol interaction 45.54 10.49 71 258329 4330 64236002
Anaphylactic shock 45.51 10.49 33 258367 30295 64210037
Tumour lysis syndrome 45.36 10.49 11 258389 19429 64220903
Alcoholism 45.35 10.49 62 258338 3355 64236977
Dehydration 45.24 10.49 604 257796 216159 64024173
Angina pectoris 45.24 10.49 69 258331 45012 64195320
Hyperphagia 45.03 10.49 50 258350 2181 64238151
Irritable bowel syndrome 44.90 10.49 50 258350 37319 64203013
Muscular weakness 44.82 10.49 312 258088 127026 64113306
Folliculitis 44.77 10.49 33 258367 30044 64210288
Sympathomimetic effect 44.76 10.49 15 258385 56 64240276
Hypocalcaemia 44.76 10.49 61 258339 41692 64198640
C-reactive protein abnormal 44.38 10.49 31 258369 29016 64211316
Stoma site erythema 44.31 10.49 38 258362 1201 64239131
Self-injurious ideation 43.93 10.49 59 258341 3138 64237194
Malignant catatonia 43.89 10.49 24 258376 353 64239979
Reduced facial expression 43.76 10.49 48 258352 2065 64238267
Myoglobin urine present 43.58 10.49 28 258372 562 64239770
Emotional disorder 43.42 10.49 130 258270 12477 64227855
Pulmonary hypertension 43.32 10.49 66 258334 43073 64197259
Fungal infection 43.19 10.49 44 258356 34207 64206125
Self esteem decreased 43.12 10.49 33 258367 884 64239448
Neck pain 43.11 10.49 116 258284 61417 64178915
Pulmonary arterial hypertension 43.00 10.49 24 258376 25343 64214989
Pyramidal tract syndrome 42.95 10.49 27 258373 521 64239811
Haematochezia 42.91 10.49 130 258270 66243 64174089
Rabbit syndrome 42.87 10.49 23 258377 325 64240007
Hyperhidrosis 42.80 10.49 721 257679 124199 64116133
Hypoaesthesia 42.74 10.49 354 258046 138754 64101578
Chronic obstructive pulmonary disease 42.55 10.49 144 258256 70904 64169428
Oral pain 42.46 10.49 29 258371 27464 64212868
Haematuria 42.36 10.49 114 258286 60357 64179975
Pericarditis 42.19 10.49 120 258280 62396 64177936
Melaena 42.17 10.49 95 258305 53453 64186879
Bacteraemia 42.08 10.49 28 258372 26883 64213449
Pseudomonas infection 41.96 10.49 10 258390 17873 64222459
Resting tremor 41.91 10.49 39 258361 1375 64238957
Pulmonary mass 41.76 10.49 22 258378 23994 64216338
Self-medication 41.68 10.49 66 258334 4079 64236253
Postural tremor 41.51 10.49 27 258373 554 64239778
Osteomyelitis 41.41 10.49 30 258370 27557 64212775
Memory impairment 41.40 10.49 525 257875 85157 64155175
Upper gastrointestinal haemorrhage 41.36 10.49 48 258352 35172 64205160
Metastases to lung 41.23 10.49 6 258394 15258 64225074
Progressive multifocal leukoencephalopathy 41.23 10.49 11 258389 18221 64222111
Hypercalcaemia 41.18 10.49 39 258361 31377 64208955
Blunted affect 41.05 10.49 24 258376 404 64239928
Tubulointerstitial nephritis 40.95 10.49 38 258362 30871 64209461
Affective disorder 40.88 10.49 85 258315 6495 64233837
Amnesia 40.86 10.49 332 258068 47937 64192395
Conversion disorder 40.83 10.49 42 258358 1677 64238655
Mental status changes 40.62 10.49 399 258001 60763 64179569
Device expulsion 40.39 10.49 17 258383 21119 64219213
Psychosexual disorder 40.18 10.49 16 258384 107 64240225
Device related infection 40.17 10.49 38 258362 30588 64209744
Wheezing 40.10 10.49 176 258224 80403 64159929
Diabetic ketoacidosis 40.06 10.49 230 258170 29615 64210717
Oropharyngeal spasm 40.00 10.49 20 258380 242 64240090
Immunodeficiency 39.89 10.49 8 258392 16116 64224216
Sudden death 39.86 10.49 173 258227 19923 64220409
Metastases to bone 39.76 10.49 16 258384 20419 64219913
Dependence 39.59 10.49 46 258354 2109 64238223
Type 1 diabetes mellitus 39.39 10.49 77 258323 5628 64234704
Sudden cardiac death 39.35 10.49 68 258332 4519 64235813
Diet refusal 39.22 10.49 30 258370 803 64239529
Pyromania 39.17 10.49 11 258389 18 64240314
Freezing phenomenon 38.96 10.49 39 258361 1507 64238825
Contusion 38.75 10.49 282 258118 113683 64126649
Angioedema 38.61 10.49 123 258277 61698 64178634
Judgement impaired 38.56 10.49 33 258367 1040 64239292
Bradypnoea 38.53 10.49 72 258328 5087 64235245
Haemorrhage 38.47 10.49 175 258225 79176 64161156
Knee arthroplasty 38.44 10.49 31 258369 26968 64213364
Infarction 38.38 10.49 62 258338 3898 64236434
Screaming 38.01 10.49 58 258342 3471 64236861
Wrong patient received product 37.97 10.49 60 258340 3702 64236630
Nephrogenic diabetes insipidus 37.59 10.49 42 258358 1845 64238487
Viral infection 37.54 10.49 54 258346 36086 64204246
Blood creatinine increased 37.54 10.49 355 258045 135427 64104905
Floppy iris syndrome 37.52 10.49 21 258379 324 64240008
Sinus congestion 37.50 10.49 8 258392 15431 64224901
Wound 37.48 10.49 168 258232 76309 64164023
Stoma site hypergranulation 37.44 10.49 22 258378 374 64239958
Haematotoxicity 37.44 10.49 4 258396 12892 64227440
Helicobacter infection 37.27 10.49 60 258340 38302 64202030
Pancreatitis 37.25 10.49 384 258016 59223 64181109
Blepharospasm 37.11 10.49 56 258344 3319 64237013
Chronic kidney disease 37.05 10.49 114 258286 57805 64182527
Decreased eye contact 37.01 10.49 28 258372 737 64239595
Feeling of body temperature change 36.98 10.49 68 258332 4746 64235586
Drug diversion 36.93 10.49 33 258367 1103 64239229
Action tremor 36.93 10.49 22 258378 384 64239948
Amniotic fluid volume increased 36.91 10.49 16 258384 136 64240196
Right ventricular failure 36.85 10.49 20 258380 21451 64218881
Gout 36.67 10.49 20 258380 21393 64218939
Hypoacusis 36.45 10.49 30 258370 25837 64214495
Gastric disorder 36.26 10.49 38 258362 29159 64211173
Pathogen resistance 36.13 10.49 4 258396 12539 64227793
Tenosynovitis 36.13 10.49 3 258397 11830 64228502
Trismus 36.11 10.49 68 258332 4833 64235499
Dystonic tremor 35.98 10.49 17 258383 180 64240152
Injection site reaction 35.77 10.49 84 258316 46580 64193752
Gambling disorder 35.76 10.49 41 258359 1853 64238479
Proteinuria 35.66 10.49 35 258365 27688 64212644
Loss of libido 35.56 10.49 46 258354 2358 64237974
Osteoporosis 35.35 10.49 72 258328 42008 64198324
Compartment syndrome 35.35 10.49 62 258338 4170 64236162
Rash maculo-papular 34.98 10.49 86 258314 46940 64193392
Throat irritation 34.85 10.49 48 258352 32663 64207669
Blood pressure systolic increased 34.81 10.49 93 258307 49360 64190972
Pulmonary fibrosis 34.78 10.49 41 258359 29837 64210495
Surgery 34.72 10.49 37 258363 28176 64212156
Metastases to liver 34.70 10.49 27 258373 23914 64216418
Tongue spasm 34.69 10.49 13 258387 72 64240260
H1N1 influenza 34.53 10.49 44 258356 2222 64238110
Adjustment disorder with mixed anxiety and depressed mood 34.40 10.49 13 258387 74 64240258
Neoplasm malignant 34.34 10.49 29 258371 24659 64215673
Libido increased 34.22 10.49 39 258361 1751 64238581
Mouth ulceration 34.18 10.49 48 258352 32396 64207936
Hot flush 34.04 10.49 85 258315 46150 64194182
Excessive eye blinking 34.01 10.49 33 258367 1227 64239105
Troponin increased 34.00 10.49 137 258263 15262 64225070
Crying 33.95 10.49 165 258235 19925 64220407
Blood glucose increased 33.93 10.49 567 257833 97506 64142826
Drug use disorder 33.93 10.49 75 258325 5979 64234353
Faeces discoloured 33.66 10.49 32 258368 25697 64214635
Anticonvulsant drug level above therapeutic 33.64 10.49 30 258370 1000 64239332
Rheumatoid factor positive 33.61 10.49 55 258345 34883 64205449
Dysphonia 33.58 10.49 86 258314 46296 64194036
Nuchal rigidity 33.57 10.49 29 258371 926 64239406
International normalised ratio increased 33.56 10.49 183 258217 78984 64161348
Lymphadenopathy 33.47 10.49 87 258313 46599 64193733
Muscle injury 33.29 10.49 34 258366 26403 64213929
Urine osmolarity increased 33.26 10.49 18 258382 259 64240073
Hypersexuality 33.09 10.49 35 258365 1444 64238888
Tongue biting 33.06 10.49 38 258362 1722 64238610
Personality disorder 33.03 10.49 64 258336 4647 64235685
Malignant melanoma 32.99 10.49 6 258394 12958 64227374
Burning mouth syndrome 32.97 10.49 22 258378 472 64239860
Brain injury 32.68 10.49 101 258299 9864 64230468
Electrocardiogram repolarisation abnormality 32.63 10.49 39 258361 1843 64238489
Lung neoplasm malignant 32.62 10.49 23 258377 21425 64218907
Multiple organ dysfunction syndrome 32.55 10.49 255 258145 101158 64139174
Eye movement disorder 32.37 10.49 81 258319 6998 64233334
Mobility decreased 32.37 10.49 206 258194 85634 64154698
Dementia with Lewy bodies 32.28 10.49 25 258375 682 64239650
Gastroenteritis 32.26 10.49 43 258357 29668 64210664
Colon cancer 32.20 10.49 6 258394 12733 64227599
Squamous cell carcinoma 32.06 10.49 8 258392 13861 64226471
Pneumothorax 32.04 10.49 30 258370 24268 64216064
Ear infection 31.93 10.49 28 258372 23376 64216956
Nodule 31.86 10.49 16 258384 17931 64222401
Penis injury 31.80 10.49 14 258386 124 64240208
Gastritis 31.65 10.49 78 258322 42540 64197792
Food interaction 31.58 10.49 34 258366 1432 64238900
Staphylococcal infection 31.53 10.49 101 258299 50577 64189755
Inappropriate antidiuretic hormone secretion 31.39 10.49 174 258226 22115 64218217
Merycism 31.26 10.49 16 258384 204 64240128
Tenderness 31.18 10.49 20 258380 19582 64220750
Injection site rash 31.16 10.49 12 258388 15730 64224602
Dysphagia 31.11 10.49 601 257799 106211 64134121
Duodenal ulcer perforation 31.04 10.49 57 258343 34568 64205764
Feelings of worthlessness 30.89 10.49 21 258379 465 64239867
Staring 30.89 10.49 43 258357 2367 64237965
Tooth infection 30.84 10.49 10 258390 14591 64225741
Ulcer 30.77 10.49 28 258372 22962 64217370
Joint effusion 30.71 10.49 8 258392 13465 64226867
Hangover 30.70 10.49 38 258362 1863 64238469
Meconium in amniotic fluid 30.68 10.49 12 258388 76 64240256
Lymphocyte count decreased 30.61 10.49 74 258326 40625 64199707
Post-traumatic stress disorder 30.56 10.49 58 258342 4147 64236185
Transfusion 30.54 10.49 17 258383 17977 64222355
Dysgeusia 30.52 10.49 92 258308 46955 64193377
Decreased interest 30.40 10.49 51 258349 3309 64237023
Foot deformity 30.39 10.49 14 258386 16490 64223842
Otospondylomegaepiphyseal dysplasia 30.34 10.49 10 258390 35 64240297
Angina unstable 30.27 10.49 12 258388 15455 64224877
Physical assault 30.09 10.49 34 258366 1512 64238820
Accidental poisoning 30.08 10.49 33 258367 1420 64238912
Joint stiffness 30.06 10.49 47 258353 30357 64209975
Coagulopathy 30.01 10.49 51 258349 31869 64208463
Flight of ideas 30 10.49 24 258376 687 64239645
Stoma site inflammation 29.98 10.49 22 258378 552 64239780
Potentiating drug interaction 29.97 10.49 84 258316 7768 64232564
Refusal of treatment by patient 29.68 10.49 87 258313 8252 64232080
Bone disorder 29.67 10.49 15 258385 16744 64223588
Immunosuppression 29.55 10.49 4 258396 10742 64229590
Withdrawal arrhythmia 29.31 10.49 10 258390 40 64240292
Peripartum cardiomyopathy 29.25 10.49 13 258387 118 64240214
Grimacing 29.24 10.49 23 258377 642 64239690
Tendonitis 29.23 10.49 23 258377 20259 64220073
Immune reconstitution inflammatory syndrome 29.21 10.49 7 258393 12463 64227869
Squamous cell carcinoma of skin 29.16 10.49 6 258394 11870 64228462
Negative thoughts 29.15 10.49 31 258369 1287 64239045
Convulsive threshold lowered 29.00 10.49 26 258374 873 64239459
Autonomic nervous system imbalance 28.81 10.49 56 258344 4076 64236256
Diabetes insipidus 28.79 10.49 59 258341 4462 64235870
Ejection fraction decreased 28.74 10.49 44 258356 28663 64211669
Herbal interaction 28.66 10.49 19 258381 403 64239929
Multiple drug therapy 28.56 10.49 40 258360 2214 64238118
Therapy interrupted 28.53 10.49 23 258377 20013 64220319
Erectile dysfunction 28.41 10.49 113 258287 12514 64227818
Apraxia 28.29 10.49 42 258358 2453 64237879
Conduction disorder 28.13 10.49 46 258354 2922 64237410
Parkinsonian rest tremor 28.08 10.49 16 258384 256 64240076
Protein C increased 27.99 10.49 12 258388 99 64240233
Jealous delusion 27.96 10.49 15 258385 212 64240120
Hypogammaglobulinaemia 27.93 10.49 4 258396 10295 64230037
Necrotising colitis 27.91 10.49 26 258374 918 64239414
Enteritis 27.85 10.49 7 258393 12070 64228262
Gastric ulcer 27.79 10.49 49 258351 30185 64210147
Hyperosmolar state 27.76 10.49 22 258378 621 64239711
Parosmia 27.74 10.49 59 258341 4581 64235751
Intestinal pseudo-obstruction 27.62 10.49 37 258363 1963 64238369
Binge eating 27.55 10.49 19 258381 431 64239901
Social anxiety disorder 27.55 10.49 19 258381 431 64239901
Morbid thoughts 27.47 10.49 23 258377 703 64239629
Acute generalised exanthematous pustulosis 27.36 10.49 11 258389 14047 64226285
Wrong patient 27.25 10.49 14 258386 180 64240152
Oxygen saturation decreased 27.20 10.49 286 258114 106890 64133442
Sexual abuse 27.16 10.49 13 258387 142 64240190
Microphthalmos 27.14 10.49 6 258394 0 64240332
Sluggishness 27.12 10.49 66 258334 5604 64234728
Injection site warmth 27.09 10.49 10 258390 13452 64226880
Delusional perception 27 10.49 17 258383 329 64240003
Dyslipidaemia 26.97 10.49 90 258310 9152 64231180
Congestive cardiomyopathy 26.94 10.49 97 258303 10247 64230085
Toxic epidermal necrolysis 26.84 10.49 69 258331 37097 64203235
Injection site urticaria 26.74 10.49 6 258394 11175 64229157
Pressure of speech 26.61 10.49 26 258374 975 64239357
Trichoglossia 26.60 10.49 17 258383 338 64239994
Cystitis 26.58 10.49 85 258315 42590 64197742
Hypomagnesaemia 26.52 10.49 70 258330 37306 64203026
Haemorrhage intracranial 26.51 10.49 34 258366 23850 64216482
Liver injury 26.49 10.49 208 258192 29724 64210608
Thrombotic microangiopathy 26.48 10.49 17 258383 16638 64223694
Acute coronary syndrome 26.47 10.49 23 258377 19287 64221045
Blood cholesterol increased 26.44 10.49 312 258088 49754 64190578
Colitis ulcerative 26.38 10.49 32 258368 22996 64217336
Neuralgia 26.34 10.49 40 258360 26144 64214188
Uveitis 26.32 10.49 9 258391 12699 64227633
Impaired self-care 26.32 10.49 39 258361 2274 64238058
Obsessive-compulsive personality disorder 26.17 10.49 12 258388 118 64240214
Skin lesion 26.14 10.49 68 258332 36414 64203918
Delusional disorder, persecutory type 26.11 10.49 18 258382 408 64239924
Oral discharge 26.05 10.49 15 258385 245 64240087
Adrenal insufficiency 26.03 10.49 31 258369 22456 64217876
Hyporesponsive to stimuli 25.98 10.49 34 258366 1763 64238569
Pulmonary haemorrhage 25.94 10.49 10 258390 13099 64227233
Diffuse large B-cell lymphoma 25.93 10.49 5 258395 10356 64229976
Sinus disorder 25.89 10.49 18 258382 16890 64223442
Patient uncooperative 25.78 10.49 20 258380 547 64239785
Psoriatic arthropathy 25.73 10.49 88 258312 43193 64197139
Ear pain 25.68 10.49 38 258362 25098 64215234
Bursitis 25.53 10.49 29 258371 21456 64218876
Penile haemorrhage 25.51 10.49 19 258381 488 64239844
Stoma site infection 25.48 10.49 28 258372 1207 64239125
Post procedural haemorrhage 25.41 10.49 9 258391 12422 64227910
Carpal tunnel syndrome 25.38 10.49 16 258384 15812 64224520
Coordination abnormal 25.36 10.49 123 258277 14841 64225491
Metastases to central nervous system 25.31 10.49 12 258388 13900 64226432
Nystagmus 25.31 10.49 87 258313 8981 64231351
Eosinopenia 25.27 10.49 9 258391 42 64240290
Gastroenteritis viral 25.27 10.49 25 258375 19704 64220628
Delusional disorder, unspecified type 25.24 10.49 22 258378 711 64239621
Skin reaction 25.15 10.49 9 258391 12343 64227989
Therapeutic product effect incomplete 25.12 10.49 279 258121 103203 64137129
Vasoplegia syndrome 25.03 10.49 42 258358 2725 64237607
Burning sensation 25.00 10.49 108 258292 49556 64190776
Psychotic disorder due to a general medical condition 24.97 10.49 15 258385 266 64240066
Excessive masturbation 24.97 10.49 10 258390 68 64240264
Borderline personality disorder 24.95 10.49 23 258377 801 64239531
Generalised oedema 24.94 10.49 28 258372 20825 64219507
Atrioventricular block first degree 24.91 10.49 97 258303 10637 64229695
Facial spasm 24.83 10.49 21 258379 651 64239681
Hypervigilance 24.80 10.49 18 258382 444 64239888
Haemorrhoids 24.79 10.49 36 258364 23965 64216367
White blood cell count decreased 24.77 10.49 464 257936 157373 64082959
Tooth disorder 24.75 10.49 32 258368 22370 64217962
Cervix neoplasm 24.65 10.49 13 258387 177 64240155
Product dose omission issue 24.58 10.49 593 257807 194154 64046178
Arrhythmia 24.55 10.49 322 258078 52622 64187710
Compulsions 24.52 10.49 16 258384 330 64240002
Brain hypoxia 24.41 10.49 23 258377 824 64239508
Personality change due to a general medical condition 24.23 10.49 12 258388 142 64240190
Persistent genital arousal disorder 24.19 10.49 14 258386 231 64240101
Disseminated intravascular coagulation 24.18 10.49 59 258341 32289 64208043
Metabolic encephalopathy 24.18 10.49 79 258321 7946 64232386
Movement disorder 24.15 10.49 161 258239 21839 64218493
Antipsychotic drug level decreased 24.13 10.49 24 258376 920 64239412
Post procedural complication 24.12 10.49 30 258370 21323 64219009
Brachial plexopathy 24.09 10.49 12 258388 144 64240188
Muscle disorder 24.07 10.49 58 258342 4893 64235439
Illness anxiety disorder 24.03 10.49 14 258386 234 64240098
Clostridium difficile infection 23.97 10.49 70 258330 36093 64204239
Lymphoma 23.90 10.49 13 258387 13928 64226404
Cholecystitis 23.89 10.49 26 258374 19610 64220722
Swelling face 23.87 10.49 139 258261 59027 64181305
Blood urine present 23.77 10.49 23 258377 18317 64222015
Flatulence 23.67 10.49 69 258331 35597 64204735
Respiratory tract infection 23.66 10.49 74 258326 37333 64202999
Haematoma 23.63 10.49 100 258300 46150 64194182
Cholangitis 23.53 10.49 7 258393 10795 64229537
Choreoathetosis 23.49 10.49 29 258371 1418 64238914
Labelled drug-food interaction issue 23.40 10.49 7 258393 16 64240316
Limb discomfort 23.25 10.49 46 258354 27129 64213203
Lip swelling 23.22 10.49 59 258341 31848 64208484
Prostate cancer 23.22 10.49 27 258373 19768 64220564
Intervertebral disc protrusion 23.19 10.49 28 258372 20163 64220169
Posterior reversible encephalopathy syndrome 23.14 10.49 35 258365 22911 64217421
Diverticulum 23.08 10.49 12 258388 13186 64227146
Flashback 23.07 10.49 14 258386 253 64240079
Fall 23.06 10.49 1954 256446 414872 63825460
Laboratory test abnormal 23.03 10.49 38 258362 24025 64216307
Skin infection 23.03 10.49 16 258384 15021 64225311
Feeling jittery 22.99 10.49 94 258306 10541 64229791
Overweight 22.90 10.49 45 258355 3301 64237031
Water intoxication 22.84 10.49 21 258379 729 64239603
Panniculitis 22.83 10.49 4 258396 8875 64231457
Eosinophilic pleural effusion 22.79 10.49 14 258386 259 64240073
Sedation complication 22.77 10.49 92 258308 10262 64230070
Gastrointestinal sounds abnormal 22.76 10.49 56 258344 4787 64235545
Gastrointestinal necrosis 22.70 10.49 57 258343 4935 64235397
Schizoaffective disorder bipolar type 22.68 10.49 11 258389 124 64240208
Retrograde ejaculation 22.65 10.49 13 258387 211 64240121
Obsessive thoughts 22.64 10.49 24 258376 993 64239339
Bone density decreased 22.51 10.49 6 258394 9946 64230386
Abdominal pain lower 22.48 10.49 45 258355 26424 64213908
Prostatic specific antigen increased 22.41 10.49 4 258396 8756 64231576
Unevaluable event 22.35 10.49 115 258285 50374 64189958
Agranulocytosis 22.34 10.49 243 258157 37986 64202346
Blood urea increased 22.23 10.49 96 258304 44057 64196275
Formication 22.22 10.49 52 258348 4305 64236027
Decreased bronchial secretion 22.13 10.49 9 258391 64 64240268
Atrial flutter 22.13 10.49 27 258373 19353 64220979
Ageusia 22.10 10.49 14 258386 13799 64226533
Aphasia 22.08 10.49 256 258144 40650 64199682
Intentional product use issue 22.01 10.49 260 258140 95104 64145228
Communication disorder 22.01 10.49 47 258353 3659 64236673
Oesophageal candidiasis 22.01 10.49 3 258397 8014 64232318
Hostility 22.00 10.49 35 258365 2172 64238160
Hypoalbuminaemia 21.95 10.49 23 258377 17651 64222681
Second primary malignancy 21.90 10.49 11 258389 12326 64228006
Urine alcohol test positive 21.81 10.49 7 258393 22 64240310
Influenza like illness 21.79 10.49 151 258249 61551 64178781
Skin exfoliation 21.75 10.49 99 258301 44786 64195546
Cytopenia 21.73 10.49 18 258382 15453 64224879
Polyarthritis 21.70 10.49 6 258394 9709 64230623
Prescription drug used without a prescription 21.60 10.49 38 258362 2562 64237770
Neonatal infection 21.57 10.49 7 258393 23 64240309
Ill-defined disorder 21.44 10.49 97 258303 43955 64196377
Renal papillary necrosis 21.42 10.49 15 258385 349 64239983
Device kink 21.39 10.49 30 258370 1663 64238669
Organising pneumonia 21.37 10.49 5 258395 9050 64231282
Cardiac failure chronic 21.32 10.49 5 258395 9036 64231296
Pneumonia viral 21.30 10.49 3 258397 7819 64232513
Drug withdrawal syndrome neonatal 21.23 10.49 13 258387 239 64240093
Blood calcium decreased 21.23 10.49 44 258356 25510 64214822
Parkinson's disease 21.17 10.49 29 258371 1572 64238760
Tuberculosis 21.16 10.49 13 258387 13025 64227307
Renal tubular necrosis 21.09 10.49 35 258365 22075 64218257
Myoclonic epilepsy 21.07 10.49 29 258371 1579 64238753
Paradoxical drug reaction 20.98 10.49 63 258337 6057 64234275
Drug dispensed to wrong patient 20.95 10.49 15 258385 362 64239970
Therapeutic product ineffective 20.91 10.49 28 258372 1485 64238847
Acute respiratory failure 20.85 10.49 116 258284 49818 64190514
Breast engorgement 20.82 10.49 8 258392 48 64240284
Faecal vomiting 20.74 10.49 23 258377 1002 64239330
Blood osmolarity decreased 20.73 10.49 25 258375 1193 64239139
Candida infection 20.69 10.49 61 258339 31358 64208974
Product storage error 20.63 10.49 14 258386 13304 64227028
Pruritus genital 20.61 10.49 23 258377 1009 64239323
Bacterial parotitis 20.60 10.49 6 258394 12 64240320
Therapeutic product effect variable 20.57 10.49 29 258371 1615 64238717
Helplessness 20.52 10.49 14 258386 312 64240020
Hyponatraemic coma 20.51 10.49 7 258393 28 64240304
Cushingoid 20.51 10.49 3 258397 7600 64232732
Cholecystitis acute 20.36 10.49 10 258390 11350 64228982
Chorea 20.33 10.49 32 258368 1968 64238364
Cardiac tamponade 20.30 10.49 4 258396 8160 64232172
Radial nerve palsy 20.30 10.49 16 258384 448 64239884
Infective pulmonary exacerbation of cystic fibrosis 20.23 10.49 11 258389 11785 64228547
Metastases to lymph nodes 20.21 10.49 5 258395 8712 64231620
Electroencephalogram abnormal 20.19 10.49 56 258344 5147 64235185
Ketoacidosis 20.17 10.49 67 258333 6796 64233536
Paralysis 20.15 10.49 96 258304 11499 64228833
Oral candidiasis 20.11 10.49 39 258361 23173 64217159
Illusion 20.10 10.49 28 258372 1542 64238790
Therapy cessation 20.03 10.49 65 258335 32424 64207908
Seasonal allergy 20.01 10.49 11 258389 11715 64228617
Hypothyroidism 20.01 10.49 249 258151 40208 64200124
Injection site haemorrhage 20 10.49 42 258358 24236 64216096
Drug level above therapeutic 19.96 10.49 67 258333 6834 64233498
Pulmonary oedema 19.94 10.49 210 258190 78464 64161868
Femur fracture 19.89 10.49 70 258330 34065 64206267
Dopamine dysregulation syndrome 19.85 10.49 16 258384 463 64239869
Jaundice cholestatic 19.84 10.49 78 258322 8592 64231740
Spinal stenosis 19.82 10.49 16 258384 13915 64226417
Orthopnoea 19.75 10.49 6 258394 9128 64231204
Hypophosphataemia 19.62 10.49 18 258382 14702 64225630
Cerebral infarction 19.60 10.49 91 258309 40953 64199379
Grandiosity 19.54 10.49 17 258383 548 64239784
Encephalitis toxic 19.52 10.49 13 258387 278 64240054
Enterocolitis 19.48 10.49 12 258388 12006 64228326
Gastrointestinal hypomotility 19.40 10.49 29 258371 1704 64238628
Apnoea 19.37 10.49 88 258312 10334 64229998
Hyperthermia malignant 19.22 10.49 35 258365 2424 64237908
C-reactive protein increased 19.22 10.49 266 258134 94643 64145689
Sense of a foreshortened future 19.17 10.49 5 258395 5 64240327
Food craving 19.14 10.49 26 258374 1398 64238934
Obsessive-compulsive symptom 19.10 10.49 10 258390 134 64240198
Tonic clonic movements 19.08 10.49 31 258369 1958 64238374
Somatic symptom disorder of pregnancy 19.07 10.49 9 258391 95 64240237
Respiratory tract congestion 19.01 10.49 22 258378 16143 64224189
Eye haemorrhage 18.99 10.49 5 258395 8355 64231977
Antidepressant drug level increased 18.92 10.49 14 258386 356 64239976
IVth nerve disorder 18.90 10.49 6 258394 18 64240314
Fear of weight gain 18.90 10.49 6 258394 18 64240314
Stoma site pain 18.86 10.49 23 258377 1110 64239222
Neurodegenerative disorder 18.82 10.49 15 258385 427 64239905
Neutrophil count decreased 18.78 10.49 208 258192 76988 64163344
Intentional medical device removal by patient 18.77 10.49 13 258387 297 64240035
Eye pruritus 18.70 10.49 14 258386 12645 64227687
Depressive delusion 18.66 10.49 6 258394 19 64240313
Poor quality sleep 18.63 10.49 135 258265 18816 64221516
Hepatic encephalopathy 18.60 10.49 35 258365 21031 64219301
Generalised anxiety disorder 18.58 10.49 30 258370 1885 64238447
Sleep disorder due to a general medical condition 18.56 10.49 5 258395 8229 64232103
Skin necrosis 18.53 10.49 18 258382 14311 64226021
Compulsive shopping 18.48 10.49 19 258381 758 64239574
Food refusal 18.44 10.49 15 258385 440 64239892
Frequent bowel movements 18.38 10.49 28 258372 18277 64222055
Heart rate decreased 18.36 10.49 137 258263 54930 64185402
Alcohol use 18.32 10.49 50 258350 4552 64235780
Graft versus host disease 18.28 10.49 17 258383 13796 64226536
Verbal abuse 18.20 10.49 12 258388 252 64240080
Pneumonia bacterial 18.19 10.49 20 258380 15015 64225317
Migraine 18.12 10.49 162 258238 62515 64177817
Thrombotic thrombocytopenic purpura 18.11 10.49 59 258341 5925 64234407
Buccoglossal syndrome 18.10 10.49 4 258396 0 64240332
Phaeochromocytoma malignant 18.06 10.49 8 258392 72 64240260
Enthesopathy 18.02 10.49 8 258392 9630 64230702
Abscess 18.00 10.49 31 258369 19273 64221059
Psychogenic tremor 17.99 10.49 6 258394 22 64240310
Anxiolytic therapy 17.99 10.49 6 258394 22 64240310
Drug therapy enhancement 17.99 10.49 6 258394 22 64240310
Withdrawal catatonia 17.94 10.49 10 258390 153 64240179
Painful erection 17.94 10.49 10 258390 153 64240179
Haemolysis 17.92 10.49 11 258389 11028 64229304
Idiopathic intracranial hypertension 17.90 10.49 35 258365 2558 64237774
Post procedural infection 17.89 10.49 8 258392 9589 64230743
Urine output decreased 17.77 10.49 24 258376 16468 64223864
Somatic symptom disorder 17.77 10.49 29 258371 1839 64238493
Oral herpes 17.69 10.49 39 258361 22113 64218219
Epidermolysis bullosa 17.65 10.49 11 258389 209 64240123
Abnormal loss of weight 17.64 10.49 4 258396 7396 64232936
Metabolic acidosis 17.62 10.49 390 258010 70568 64169764
Gait disturbance 17.59 10.49 851 257549 171304 64069028
Neurological symptom 17.56 10.49 64 258336 6800 64233532
Respiratory distress 17.54 10.49 130 258270 52201 64188131
Lack of spontaneous speech 17.51 10.49 11 258389 212 64240120
Hernia 17.46 10.49 17 258383 13501 64226831
Hepatic failure 17.44 10.49 140 258260 55254 64185078
Skin disorder 17.33 10.49 55 258345 27625 64212707
Pancreatic carcinoma 17.31 10.49 10 258390 10363 64229969
Adverse drug reaction 17.27 10.49 267 258133 45197 64195135
Breast discharge 17.27 10.49 16 258384 561 64239771
Drug resistance 17.26 10.49 77 258323 35025 64205307
Product use issue 17.26 10.49 469 257931 151246 64089086
Musculoskeletal discomfort 17.22 10.49 24 258376 16253 64224079
Blood sodium increased 17.22 10.49 47 258353 4279 64236053
Electrocardiogram change 17.22 10.49 22 258378 1114 64239218
Atelectasis 17.20 10.49 54 258346 27212 64213120
Conjunctival abrasion 17.17 10.49 5 258395 10 64240322
Congenital cerebrovascular anomaly 17.17 10.49 5 258395 10 64240322
Head titubation 17.16 10.49 19 258381 826 64239506
Bladder prolapse 17.14 10.49 22 258378 1119 64239213
Gaze palsy 17.10 10.49 34 258366 2516 64237816
Megacolon 17.07 10.49 38 258362 3044 64237288
Liver function test increased 17.06 10.49 65 258335 30905 64209427
Device difficult to use 17 10.49 9 258391 9789 64230543
Breast cancer metastatic 16.84 10.49 4 258396 7165 64233167
Pulmonary alveolar haemorrhage 16.82 10.49 9 258391 9729 64230603
Pyelonephritis 16.78 10.49 27 258373 17239 64223093
Choking 16.71 10.49 85 258315 10453 64229879
Sneezing 16.63 10.49 22 258378 15229 64225103
Skin mass 16.62 10.49 4 258396 7102 64233230
Bladder dilatation 16.58 10.49 28 258372 1826 64238506
Laryngitis 16.55 10.49 12 258388 11019 64229313
Contraindication to medical treatment 16.52 10.49 20 258380 958 64239374
Electroconvulsive therapy 16.51 10.49 8 258392 90 64240242
Feeling hot 16.49 10.49 111 258289 45552 64194780
Initial insomnia 16.48 10.49 56 258344 5748 64234584
Herpes simplex 16.42 10.49 11 258389 10525 64229807
Panic disorder 16.41 10.49 35 258365 2722 64237610
Haematocrit decreased 16.36 10.49 140 258260 54515 64185817
Osteopenia 16.36 10.49 23 258377 15517 64224815
Anamnestic reaction 16.35 10.49 6 258394 31 64240301
Rash macular 16.32 10.49 45 258355 23640 64216692
Kidney infection 16.31 10.49 29 258371 17809 64222523
Nonspecific reaction 16.28 10.49 29 258371 1974 64238358
Refusal of examination 16.28 10.49 8 258392 93 64240239
Procedural pain 16.28 10.49 23 258377 15485 64224847
False positive investigation result 16.25 10.49 18 258382 783 64239549
End stage renal disease 16.24 10.49 11 258389 10464 64229868
Wrong technique in product usage process 16.23 10.49 174 258226 64800 64175532
Immune thrombocytopenia 16.16 10.49 22 258378 15044 64225288
Peritonitis bacterial 16.15 10.49 8 258392 9035 64231297
Conjunctivitis 16.11 10.49 36 258364 20318 64220014
Aortic stenosis 16.08 10.49 3 258397 6362 64233970
Abnormal dreams 16.05 10.49 83 258317 10273 64230059
Ventricular fibrillation 16.00 10.49 156 258244 23704 64216628
Gait deviation 16.00 10.49 7 258393 61 64240271
Delusion of reference 15.96 10.49 9 258391 141 64240191
Bacterial sepsis 15.94 10.49 5 258395 7452 64232880
Antidepressant drug level above therapeutic 15.93 10.49 15 258385 537 64239795
Heparin-induced thrombocytopenia 15.91 10.49 7 258393 8472 64231860
Hepatic cancer 15.91 10.49 5 258395 7443 64232889
Poriomania 15.91 10.49 10 258390 193 64240139
Distal intestinal obstruction syndrome 15.90 10.49 16 258384 622 64239710
Rotator cuff syndrome 15.90 10.49 15 258385 12092 64228240
Multiple sclerosis relapse 15.87 10.49 98 258302 41037 64199295
Intermittent explosive disorder 15.87 10.49 4 258396 3 64240329
Crush injury 15.87 10.49 4 258396 3 64240329
Red blood cell count decreased 15.83 10.49 121 258279 48265 64192067
Postoperative wound infection 15.83 10.49 11 258389 10325 64230007
Device malfunction 15.83 10.49 29 258371 17604 64222728
Mitral valve incompetence 15.81 10.49 51 258349 25487 64214845
Breast enlargement 15.81 10.49 23 258377 1319 64239013
Epstein-Barr virus infection 15.79 10.49 16 258384 12472 64227860
Tendon rupture 15.78 10.49 12 258388 10755 64229577
Waxy flexibility 15.78 10.49 11 258389 254 64240078
Postmortem blood drug level 15.74 10.49 11 258389 255 64240077
Pulmonary embolism 15.70 10.49 727 257673 145629 64094703
Camptocormia 15.69 10.49 14 258386 467 64239865
Lung adenocarcinoma 15.68 10.49 4 258396 6829 64233503
Antisocial behaviour 15.68 10.49 15 258385 548 64239784
Electrocardiogram ST segment elevation 15.57 10.49 64 258336 7195 64233137
Neurological decompensation 15.52 10.49 46 258354 4390 64235942
Product quality issue 15.49 10.49 64 258336 29735 64210597
Hyperglycaemic hyperosmolar nonketotic syndrome 15.43 10.49 26 258374 1693 64238639
Sarcoidosis 15.31 10.49 3 258397 6143 64234189
Dry mouth 15.29 10.49 333 258067 60085 64180247
Respiratory acidosis 15.28 10.49 79 258321 9776 64230556
Hepatic cirrhosis 15.27 10.49 54 258346 26244 64214088
Postmortem blood drug level increased 15.26 10.49 17 258383 744 64239588
Libido decreased 15.24 10.49 48 258352 4736 64235596
Complication associated with device 15.21 10.49 23 258377 15057 64225275
Brachial plexus injury 15.17 10.49 8 258392 109 64240223
Spinal disorder 15.15 10.49 8 258392 8714 64231618
Hip arthroplasty 15.14 10.49 40 258360 21311 64219021
Bladder cancer 15.13 10.49 13 258387 10961 64229371
Starvation ketoacidosis 15.04 10.49 8 258392 111 64240221
Ejaculation disorder 15.03 10.49 14 258386 494 64239838
Respiratory disorder 15.01 10.49 84 258316 36027 64204305
Dermatitis 15.01 10.49 31 258369 17998 64222334
Selective mutism 14.99 10.49 7 258393 72 64240260
Multiple fractures 14.94 10.49 3 258397 6037 64234295
Cyanosis 14.93 10.49 145 258255 22010 64218322
Deafness 14.92 10.49 32 258368 18327 64222005
Ileus paralytic 14.86 10.49 70 258330 8345 64231987
Lipids increased 14.86 10.49 23 258377 1394 64238938
Blood iron decreased 14.86 10.49 16 258384 12126 64228206
Hyperdynamic left ventricle 14.86 10.49 11 258389 280 64240052
Guillain-Barre syndrome 14.82 10.49 6 258394 7629 64232703
Brain natriuretic peptide increased 14.81 10.49 6 258394 7627 64232705
Oedema 14.81 10.49 269 258131 91666 64148666
Hospitalisation 14.79 10.49 212 258188 74995 64165337
Hyperglycaemia 14.79 10.49 334 258066 60634 64179698
Violence-related symptom 14.76 10.49 16 258384 679 64239653
Renal tubular disorder 14.75 10.49 3 258397 5984 64234348
Toxic encephalopathy 14.75 10.49 78 258322 9737 64230595
Musculoskeletal disorder 14.73 10.49 31 258369 17875 64222457
Infusion site pain 14.72 10.49 12 258388 10385 64229947
Tachypnoea 14.66 10.49 167 258233 26404 64213928
Orthostatic hypotension 14.64 10.49 266 258134 46472 64193860
Creatinine renal clearance decreased 14.54 10.49 22 258378 14399 64225933
Urine sodium increased 14.53 10.49 9 258391 169 64240163
Arthritis infective 14.52 10.49 5 258395 7025 64233307
Bronchial aspiration procedure 14.49 10.49 10 258390 227 64240105
Disturbance in sexual arousal 14.49 10.49 9 258391 170 64240162
Aplasia pure red cell 14.47 10.49 5 258395 7009 64233323
Medical device site injury 14.45 10.49 4 258396 6 64240326
Tourette's disorder 14.43 10.49 7 258393 79 64240253
Nephrogenic systemic fibrosis 14.42 10.49 3 258397 5889 64234443
Peripheral arterial occlusive disease 14.38 10.49 5 258395 6982 64233350
Appendicitis 14.37 10.49 20 258380 13549 64226783
Hallucination, olfactory 14.36 10.49 13 258387 442 64239890
Bronchospasm 14.35 10.49 42 258358 21640 64218692
Polymerase chain reaction 14.32 10.49 8 258392 123 64240209
Aortic arteriosclerosis 14.31 10.49 6 258394 7470 64232862
Bulimia nervosa 14.31 10.49 10 258390 232 64240100
Neuroleptic-induced deficit syndrome 14.28 10.49 5 258395 22 64240310
Bone marrow eosinophilic leukocyte count increased 14.28 10.49 5 258395 22 64240310
Confabulation 14.26 10.49 13 258387 446 64239886
Pupillary light reflex tests abnormal 14.24 10.49 11 258389 299 64240033
Volvulus 14.16 10.49 29 258371 2192 64238140
Blood pressure fluctuation 14.16 10.49 136 258264 51735 64188597
Enterococcal infection 14.13 10.49 21 258379 13845 64226487
Tooth injury 14.12 10.49 22 258378 1341 64238991
Anion gap increased 14.10 10.49 35 258365 3009 64237323
Lacrimation increased 14.08 10.49 33 258367 18313 64222019
Dysmetropsia 14.05 10.49 7 258393 84 64240248
Perinatal depression 14.05 10.49 11 258389 305 64240027
Cataplexy 14.05 10.49 17 258383 814 64239518
Lymphopenia 14.03 10.49 54 258346 25603 64214729
Flat affect 13.97 10.49 26 258374 1831 64238501
Groin pain 13.95 10.49 15 258385 11378 64228954
Induced abortion failed 13.95 10.49 9 258391 182 64240150
Distractibility 13.95 10.49 15 258385 631 64239701
Blood alkaline phosphatase increased 13.94 10.49 151 258249 56128 64184204
Salivary gland calculus 13.94 10.49 10 258390 242 64240090
Cerebral haemorrhage 13.93 10.49 134 258266 50956 64189376
Autism spectrum disorder 13.91 10.49 18 258382 923 64239409
Diabetic complication 13.90 10.49 20 258380 1135 64239197
Drug abuser 13.90 10.49 53 258347 5755 64234577
Epigastric discomfort 13.80 10.49 5 258395 6806 64233526
Macular degeneration 13.78 10.49 3 258397 5707 64234625
Bradycardia 13.72 10.49 592 257808 117627 64122705
Electrocardiogram T wave inversion 13.70 10.49 47 258353 4847 64235485
Cardiac failure acute 13.70 10.49 28 258372 16316 64224016
Aphthous ulcer 13.69 10.49 19 258381 12887 64227445
Gastritis erosive 13.68 10.49 11 258389 9584 64230748
Gynaecomastia 13.67 10.49 54 258346 5962 64234370
Thought blocking 13.65 10.49 9 258391 189 64240143
Respiratory syncytial virus infection 13.64 10.49 6 258394 7262 64233070
Amimia 13.64 10.49 6 258394 53 64240279
Glomerular filtration rate decreased 13.63 10.49 37 258363 19535 64220797
Duodenal ulcer 13.63 10.49 23 258377 14412 64225920
Peripheral vascular disorder 13.62 10.49 6 258394 7255 64233077
Hepatitis B 13.61 10.49 7 258393 7738 64232594
Abdominal distension 13.60 10.49 287 258113 95707 64144625
Erotomanic delusion 13.57 10.49 3 258397 0 64240332
Lack of satiety 13.57 10.49 3 258397 0 64240332
Antidepressant drug level 13.57 10.49 3 258397 0 64240332
Dysphemia 13.55 10.49 35 258365 3084 64237248
Rib fracture 13.53 10.49 50 258350 23988 64216344
Spinal compression fracture 13.53 10.49 24 258376 14751 64225581
Paraesthesia 13.50 10.49 423 257977 134099 64106233
Labelled drug-drug interaction issue 13.46 10.49 12 258388 400 64239932
Poor venous access 13.45 10.49 18 258382 12399 64227933
Nail disorder 13.45 10.49 9 258391 8615 64231717
Graft versus host disease in gastrointestinal tract 13.44 10.49 3 258397 5609 64234723
Chromaturia 13.42 10.49 46 258354 22565 64217767
Sleep terror 13.36 10.49 20 258380 1177 64239155
Indifference 13.36 10.49 10 258390 259 64240073
Patient isolation 13.36 10.49 6 258394 56 64240276
Lower gastrointestinal haemorrhage 13.35 10.49 22 258378 13917 64226415
Aplastic anaemia 13.31 10.49 22 258378 13898 64226434
Hypernatraemia 13.26 10.49 89 258311 12100 64228232
Tongue paralysis 13.21 10.49 12 258388 410 64239922
Rhinitis allergic 13.18 10.49 8 258392 8070 64232262
Scoliosis 13.14 10.49 4 258396 6078 64234254
Tooth abscess 13.08 10.49 22 258378 13804 64226528
Rebound psychosis 13.07 10.49 8 258392 147 64240185
Endocarditis 13.06 10.49 11 258389 9367 64230965
Patella fracture 13.03 10.49 23 258377 1555 64238777
Central nervous system injury 13.02 10.49 8 258392 148 64240184
Eczema 12.98 10.49 68 258332 29652 64210680
Hyperuricaemia 12.95 10.49 13 258387 10178 64230154
Mass 12.95 10.49 26 258374 15250 64225082
Aspartate aminotransferase increased 12.93 10.49 373 258027 119415 64120917
Haematemesis 12.93 10.49 123 258277 46876 64193456
Arterial occlusive disease 12.90 10.49 6 258394 7027 64233305
Posturing 12.89 10.49 18 258382 994 64239338
Allergic hepatitis 12.87 10.49 5 258395 31 64240301
Transient ischaemic attack 12.86 10.49 114 258286 44068 64196264
Peritonitis 12.85 10.49 54 258346 24969 64215363
Polyneuropathy 12.83 10.49 39 258361 19855 64220477
Immobilisation prolonged 12.80 10.49 7 258393 103 64240229
Multiple-drug resistance 12.80 10.49 5 258395 6497 64233835
Hepatocellular carcinoma 12.79 10.49 9 258391 8394 64231938
Vasculitis 12.75 10.49 34 258366 18061 64222271
Postoperative respiratory failure 12.74 10.49 8 258392 154 64240178
Feminisation acquired 12.74 10.49 5 258395 32 64240300
Mixed dementia 12.69 10.49 10 258390 280 64240052
Ocular hyperaemia 12.66 10.49 47 258353 22517 64217815
Echolalia 12.61 10.49 11 258389 356 64239976
Fear of injection 12.57 10.49 4 258396 5908 64234424
Musculoskeletal chest pain 12.54 10.49 44 258356 21435 64218897
Stab wound 12.54 10.49 9 258391 218 64240114
Retinal haemorrhage 12.54 10.49 7 258393 7391 64232941
Asocial behaviour 12.50 10.49 6 258394 66 64240266
Alanine aminotransferase abnormal 12.44 10.49 6 258394 6882 64233450
Gastrointestinal toxicity 12.44 10.49 3 258397 5319 64235013
Delirium febrile 12.42 10.49 6 258394 67 64240265
Stoma site extravasation 12.42 10.49 10 258390 289 64240043
Renal cancer 12.40 10.49 6 258394 6869 64233463
Malignant polyp 12.39 10.49 8 258392 162 64240170
Female sexual dysfunction 12.36 10.49 5 258395 35 64240297
Vitamin K decreased 12.34 10.49 6 258394 68 64240264
Intervertebral disc degeneration 12.30 10.49 21 258379 13099 64227233
Liver abscess 12.29 10.49 3 258397 5277 64235055
Cholinergic syndrome 12.27 10.49 16 258384 827 64239505
Cardiopulmonary failure 12.15 10.49 53 258347 6117 64234215
Eye swelling 12.12 10.49 47 258353 22234 64218098
Stoma site odour 12.12 10.49 6 258394 71 64240261
Bacterial infection 12.10 10.49 55 258345 24895 64215437
Heart rate abnormal 12.09 10.49 46 258354 4989 64235343
Synovial cyst 12.07 10.49 8 258392 7699 64232633
Wrong product administered 12.05 10.49 62 258338 7658 64232674
Neuropsychiatric symptoms 12.03 10.49 17 258383 949 64239383
Small intestinal obstruction 12.02 10.49 51 258349 23522 64216810
Spasmodic dysphonia 12.01 10.49 8 258392 171 64240161
Muscle spasticity 11.99 10.49 31 258369 16638 64223694
Anhedonia 11.99 10.49 95 258305 13611 64226721
Glycosuria 11.97 10.49 26 258374 2048 64238284
Tricuspid valve incompetence 11.95 10.49 32 258368 16971 64223361
Pseudomonal sepsis 11.92 10.49 3 258397 5169 64235163
Portal hypertension 11.89 10.49 5 258395 6214 64234118
Drug specific antibody present 11.86 10.49 3 258397 5151 64235181
Splenic injury 11.86 10.49 9 258391 238 64240094
Metastasis 11.85 10.49 4 258396 5691 64234641
Cytomegalovirus test positive 11.83 10.49 3 258397 5141 64235191
Muscle atrophy 11.78 10.49 13 258387 9745 64230587
Polyp 11.77 10.49 6 258394 6667 64233665
Dialysis 11.77 10.49 32 258368 16888 64223444
Compulsive sexual behaviour 11.76 10.49 9 258391 241 64240091
Drug monitoring procedure incorrectly performed 11.75 10.49 11 258389 391 64239941
Cerebral atrophy 11.72 10.49 59 258341 7226 64233106
Stoma site induration 11.69 10.49 5 258395 41 64240291
Aortic aneurysm 11.68 10.49 8 258392 7566 64232766
Diastolic dysfunction 11.65 10.49 11 258389 8864 64231468
COVID-19 pneumonia 11.64 10.49 31 258369 16473 64223859
Hysterectomy 11.63 10.49 3 258397 5082 64235250
Toxic skin eruption 11.60 10.49 39 258361 19245 64221087
Thrombosis in device 11.58 10.49 3 258397 5068 64235264
Ammonia increased 11.57 10.49 57 258343 6920 64233412
Encopresis 11.56 10.49 7 258393 126 64240206
Lactate pyruvate ratio increased 11.56 10.49 6 258394 79 64240253
Retinal detachment 11.55 10.49 9 258391 7967 64232365
Increased tendency to bruise 11.54 10.49 12 258388 9243 64231089
Propulsive gait 11.50 10.49 3 258397 3 64240329
Lymphocyte count 11.50 10.49 3 258397 3 64240329
Breast discomfort 11.48 10.49 10 258390 323 64240009
Large intestine polyp 11.45 10.49 16 258384 10821 64229511
Haemolytic anaemia 11.44 10.49 30 258370 16023 64224309
Sleep talking 11.39 10.49 17 258383 998 64239334
Laryngeal dyspnoea 11.36 10.49 9 258391 254 64240078
Delusion of grandeur 11.35 10.49 13 258387 587 64239745
Rapid eye movement sleep behaviour disorder 11.27 10.49 10 258390 331 64240001
Rhinitis 11.26 10.49 16 258384 10749 64229583
Subdural haematoma 11.26 10.49 66 258334 27988 64212344
Oesophageal food impaction 11.25 10.49 10 258390 332 64240000
Dermatitis exfoliative 11.22 10.49 15 258385 10337 64229995
Haemorrhagic stroke 11.22 10.49 14 258386 9937 64230395
Gastric cancer 11.21 10.49 6 258394 6487 64233845
Gingival bleeding 11.17 10.49 27 258373 14827 64225505
Neurological examination abnormal 11.17 10.49 12 258388 504 64239828
Drug withdrawal headache 11.17 10.49 6 258394 85 64240247
Cardiotoxicity 11.16 10.49 75 258325 10199 64230133
Arthritis bacterial 11.16 10.49 9 258391 7830 64232502
Non-cardiac chest pain 11.12 10.49 11 258389 8669 64231663
Asphyxia 11.11 10.49 71 258329 9495 64230837
Constipation 11.09 10.49 780 257620 228557 64011775
Myoglobin blood increased 11.09 10.49 30 258370 2717 64237615
Hepatic enzyme increased 11.09 10.49 417 257983 129526 64110806
Corneal reflex decreased 11.07 10.49 10 258390 339 64239993
Premature labour 11.07 10.49 60 258340 7560 64232772
Electrolyte substitution therapy 11.05 10.49 3 258397 4 64240328
Circumcision 11.05 10.49 3 258397 4 64240328
Dysuria 11.03 10.49 233 258167 41824 64198508
Purpura 10.99 10.49 34 258366 17212 64223120
Cataract 10.98 10.49 142 258258 51120 64189212
Vascular dementia 10.98 10.49 15 258385 811 64239521
Troponin I increased 10.96 10.49 37 258363 3784 64236548
Learning disability 10.96 10.49 8 258392 199 64240133
Gastrointestinal perforation 10.96 10.49 4 258396 5420 64234912
Muscle contractions involuntary 10.92 10.49 33 258367 3184 64237148
Catheterisation cardiac 10.90 10.49 3 258397 4870 64235462
Meniscus injury 10.89 10.49 5 258395 5902 64234430
Escherichia bacteraemia 10.89 10.49 4 258396 5399 64234933
Skull fracture 10.88 10.49 21 258379 1520 64238812
Electrocardiogram QT interval 10.87 10.49 7 258393 141 64240191
Pathological fracture 10.87 10.49 12 258388 8993 64231339
Myocardial ischaemia 10.84 10.49 52 258348 23199 64217133
Gingival pain 10.83 10.49 6 258394 6361 64233971
Defect conduction intraventricular 10.81 10.49 10 258390 350 64239982
Ischaemic stroke 10.78 10.49 70 258330 28965 64211367
Grip strength decreased 10.78 10.49 19 258381 11705 64228627
Dry eye 10.75 10.49 70 258330 28949 64211383
Blood folate decreased 10.74 10.49 17 258383 1050 64239282
Protein urine present 10.74 10.49 12 258388 8944 64231388
Cerebellar atrophy 10.73 10.49 17 258383 1051 64239281
Rash erythematous 10.69 10.49 134 258266 48499 64191833
Oropharyngeal discomfort 10.67 10.49 4 258396 5331 64235001
Sickle cell anaemia with crisis 10.66 10.49 4 258396 5328 64235004
Adjusted calcium increased 10.66 10.49 5 258395 52 64240280
Hereditary angioedema 10.66 10.49 37 258363 3839 64236493
Coronary artery occlusion 10.65 10.49 25 258375 13866 64226466
Gingivitis 10.65 10.49 9 258391 7650 64232682
Necrotising fasciitis 10.64 10.49 4 258396 5322 64235010
Abdominal abscess 10.63 10.49 6 258394 6298 64234034
Respiratory fatigue 10.59 10.49 8 258392 210 64240122
Oral infection 10.58 10.49 3 258397 4774 64235558
Delusion of replacement 10.58 10.49 7 258393 148 64240184
Blood potassium decreased 10.58 10.49 107 258293 40292 64200040
Gallbladder disorder 10.55 10.49 34 258366 16996 64223336
Autoimmune hepatitis 10.54 10.49 15 258385 10069 64230263
Eye infection 10.52 10.49 13 258387 9268 64231064
Ventricular arrhythmia 10.51 10.49 58 258342 7357 64232975

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tricuspid valve incompetence 31.96 25.25 21 2124 52 82481
Meconium aspiration syndrome 31.79 25.25 19 2126 37 82496
Hypertonia neonatal 29.93 25.25 39 2106 288 82245
Withdrawal syndrome 26.16 25.25 22 2123 89 82444

Pharmacologic Action:

SourceCodeDescription
ATC N05AH04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000928 Antidepressive Agents
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bipolar disorder indication 13746004 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Depression Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Asthenia contraindication 13791008
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Leukopenia contraindication 84828003 DOID:615
Bilateral cataracts contraindication 95722004
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Anemia contraindication 271737000 DOID:2355
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
At risk for aspiration contraindication 371736008
Impaired cognition contraindication 386806002
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.94 Basic
pKa2 3.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST IC50 6.48 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST IC50 7.13 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(1A) dopamine receptor GPCR Ki 6.41 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.44 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.02 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.24 CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 6.03 IUPHAR
5-hydroxytryptamine receptor 1A GPCR IC50 6.83 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR IC50 6.52 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST IC50 7 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 5.85 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.51 PDSP
Alpha-1A adrenergic receptor GPCR IC50 7.03 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.13 PDSP
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.49 CHEMBL
D(1B) dopamine receptor GPCR Ki 5.79 PDSP
Histamine H1 receptor GPCR IC50 8.35 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.25 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.04 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 5.80 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.27 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 5.52 PDSP
Aldehyde oxidase Enzyme IC50 5.85 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 5.82 PDSP
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 5.70 IUPHAR
Alpha-2C adrenergic receptor GPCR IC50 6.24 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 5.80 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.46 DRUG MATRIX
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 5.60 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.90 IUPHAR
Alpha-1B adrenergic receptor GPCR Ki 7.41 PDSP
Histone H1.0 Nuclear other Ki 8 CHEMBL
5-hydroxytryptamine receptor 5A GPCR Ki 5.51 PDSP
Alpha-1B adrenergic receptor GPCR Ki 7.87 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.94 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.06 CHEMBL
Histamine H1 receptor GPCR Ki 7.40 CHEMBL
D(2) dopamine receptor GPCR Ki 6.74 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.64 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 6.66 CHEMBL
Histamine H1 receptor GPCR IC50 7.40 CHEMBL
Transporter Transporter Ki 6.17 CHEMBL

External reference:

IDSource
4024080 VUID
N0000022085 NUI
D00458 KEGG_DRUG
111974-72-2 SECONDARY_CAS_RN
4021057 VANDF
4024080 VANDF
C0123091 UMLSCUI
CHEBI:8707 CHEBI
CHEMBL716 ChEMBL_ID
DB01224 DRUGBANK_ID
CHEMBL1200911 ChEMBL_ID
CHEMBL3188993 ChEMBL_ID
D000069348 MESH_DESCRIPTOR_UI
5002 PUBCHEM_CID
50 IUPHAR_LIGAND_ID
7467 INN_ID
BGL0JSY5SI UNII
221153 RXNORM
11319 MMSL
187788 MMSL
33804 MMSL
5399 MMSL
d04220 MMSL
006939 NDDF
006940 NDDF
108383008 SNOMEDCT_US
108443001 SNOMEDCT_US
386850001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0220 TABLET 25 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0221 TABLET 100 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0222 TABLET 200 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0223 TABLET 300 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0229 TABLET 50 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine Fumarate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0230 TABLET 400 mg ORAL ANDA 34 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-2063 TABLET, FILM COATED 25 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8162 TABLET, FILM COATED 100 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8163 TABLET, FILM COATED 200 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8164 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8165 TABLET, FILM COATED 400 mg ORAL ANDA 32 sections
Quetiapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-8166 TABLET, FILM COATED 50 mg ORAL ANDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0271 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0272 TABLET, FILM COATED 200 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0274 TABLET, FILM COATED 300 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0275 TABLET, FILM COATED 25 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0278 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
SEROQUEL HUMAN PRESCRIPTION DRUG LABEL 1 0310-0279 TABLET, FILM COATED 400 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0280 TABLET, EXTENDED RELEASE 50 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0281 TABLET, EXTENDED RELEASE 150 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0282 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0283 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 32 sections
SEROQUELXR HUMAN PRESCRIPTION DRUG LABEL 1 0310-0284 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 32 sections
Quetiapine FumarateExtended-Release Human Prescription Drug Label 1 0406-1180 TABLET, EXTENDED RELEASE 50 mg ORAL ANDA 33 sections