clotiapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| psychoactive | 717 | 2058-52-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
| 80 | mg | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug abuse | 153.99 | 68.17 | 47 | 464 | 63361 | 46622190 |
| Sopor | 104.17 | 68.17 | 27 | 484 | 19801 | 46665750 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sopor | 202.33 | 64.03 | 47 | 616 | 10944 | 29940871 |
| Drug abuse | 112.63 | 64.03 | 48 | 615 | 82024 | 29869791 |
| Sudden death | 87.38 | 64.03 | 26 | 637 | 15466 | 29936349 |
| Toxicity to various agents | 72.55 | 64.03 | 46 | 617 | 177137 | 29774678 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AH06 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diazepines, oxazepines, thiazepines and oxepines |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.59 | Basic |
| pKa2 | 3.09 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 9.31 | CHEMBL | |||||
| Muscarinic acetylcholine receptor | GPCR | Ki | 6.87 | CHEMBL | |||||
| Serotonin 2 (5-HT2) receptor | GPCR | Ki | 9.23 | CHEMBL | |||||
| D(1A) dopamine receptor | GPCR | Ki | 7.85 | CHEMBL | |||||
| D(2) dopamine receptor | GPCR | Ki | 8.36 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01597 | KEGG_DRUG |
| C0009071 | UMLSCUI |
| CHEBI:31424 | CHEBI |
| CHEMBL304902 | ChEMBL_ID |
| DB13256 | DRUGBANK_ID |
| C084602 | MESH_SUPPLEMENTAL_RECORD_UI |
| 16351 | PUBCHEM_CID |
| 2136 | INN_ID |
| Z05HCY0X1T | UNII |
| 2620 | RXNORM |
| 006953 | NDDF |
| 698028004 | SNOMEDCT_US |
Pharmaceutical products:
None