clotiapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
psychoactive	717	2058-52-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clothiapine
clothiapin
clotiapine
entumine

Molecular weight: 343.87
Formula: C18H18ClN3S
CLOGP: 4.28
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 18.84
ALOGS: -4.38
ROTB: 0

Drug dosage:

Dose	Unit	Route
80	mg	O
80	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	202.19	86.49	57	506	72461	63415998
Sopor	190.55	86.49	43	520	22121	63466338

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	224.40	65.80	53	792	12083	34944003
Drug abuse	124.64	65.80	56	789	99040	34857046
Sudden death	85.50	65.80	26	819	15175	34940911
Toxicity to various agents	80.06	65.80	53	792	200309	34755777

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	393.57	60.96	96	1375	32914	79710003
Drug abuse	304.24	60.96	113	1358	162578	79580339
Toxicity to various agents	106.65	60.96	76	1395	421464	79321453
Intentional self-injury	100.31	60.96	33	1438	32386	79710531
Sudden death	82.20	60.96	26	1445	22485	79720432
Depressed level of consciousness	71.36	60.96	35	1436	96617	79646300
Suicide attempt	61.09	60.96	30	1441	82902	79660015

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AH06	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diazepines, oxazepines, thiazepines and oxepines
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	Basic
pKa2	3.09	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	9.31		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	8.36		CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	7.85		CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		Ki	6.87		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	9.23		CHEMBL

External reference:

ID	Source
D01597	KEGG_DRUG
2620	RXNORM
C0009071	UMLSCUI
CHEBI:31424	CHEBI
CHEMBL304902	ChEMBL_ID
DB13256	DRUGBANK_ID
C084602	MESH_SUPPLEMENTAL_RECORD_UI
16351	PUBCHEM_CID
006953	NDDF
698028004	SNOMEDCT_US
2136	INN_ID
Z05HCY0X1T	UNII

Pharmaceutical products:

None