clotiapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 717 2058-52-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clothiapine
  • clothiapin
  • clotiapine
  • entumine
  • Molecular weight: 343.87
  • Formula: C18H18ClN3S
  • CLOGP: 4.28
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 18.84
  • ALOGS: -4.38
  • ROTB: 0

Drug dosage:

DoseUnitRoute
80 mg O
80 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 153.99 68.17 47 464 63361 46622190
Sopor 104.17 68.17 27 484 19801 46665750

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 202.33 64.03 47 616 10944 29940871
Drug abuse 112.63 64.03 48 615 82024 29869791
Sudden death 87.38 64.03 26 637 15466 29936349
Toxicity to various agents 72.55 64.03 46 617 177137 29774678

Pharmacologic Action:

SourceCodeDescription
ATC N05AH06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 3.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9.31 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 6.87 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 9.23 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.85 CHEMBL
D(2) dopamine receptor GPCR Ki 8.36 CHEMBL

External reference:

IDSource
D01597 KEGG_DRUG
C0009071 UMLSCUI
CHEBI:31424 CHEBI
CHEMBL304902 ChEMBL_ID
DB13256 DRUGBANK_ID
C084602 MESH_SUPPLEMENTAL_RECORD_UI
16351 PUBCHEM_CID
2136 INN_ID
Z05HCY0X1T UNII
2620 RXNORM
006953 NDDF
698028004 SNOMEDCT_US

Pharmaceutical products:

None