olanzapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1982 132539-06-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • olanzapine pamoate
  • olanzapine embonate
  • zyprexa relprevv
  • olanzapine pamoate monohydrate
  • olanzapine
  • zyprexa
  • LY 170053
  • LY-170053
The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown.
  • Molecular weight: 312.44
  • Formula: C17H20N4S
  • CLOGP: 2.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.52
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.318 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.604 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 30.479 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 43.551 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 20.860 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 35.040 % High 1
herg hERG pIC50 5.372 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.901 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 9.204 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 18.920 % High 1
kinase-safety-class ACVR2B,BRAF,CAMK2D,EIF2AK3,ERBB2,GRK2,ITK,PDK2,PDK4,PRKDC 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.811 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.869 High 1
mh-clint Mouse hepatocyte intrinsic clearance 118.032 High 1
mppb Mouse plasma protein binding (% unbound) 18.090 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.113 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 30.680 % High 1
rat-kpuu-brain Rat brain Kpuu 0.547 % High 1
rh-clint Rat hepatocyte intrinsic clearance 155.239 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 65.320 % High 1
rppb Rat plasma protein binding (% unbound) 15.610 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 630.957 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1996 FDA LILLY
Sept. 27, 1996 EMA Eli Lilly Nederland B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1969.01 12.10 766 132823 14330 90480528
Suicide attempt 1876.59 12.10 1244 132345 74155 90420703
Sedation 1421.20 12.10 885 132704 47286 90447572
Intentional overdose 1415.11 12.10 1144 132445 92690 90402168
Extrapyramidal disorder 1330.10 12.10 592 132997 15711 90479147
Dystonia 1211.63 12.10 560 133029 16259 90478599
Akathisia 1163.31 12.10 482 133107 10677 90484181
Electrocardiogram QT prolonged 1080.69 12.10 878 132711 71578 90423280
Toxicity to various agents 1055.20 12.10 1675 131914 286171 90208687
Sopor 984.60 12.10 551 133038 24093 90470765
Schizophrenia 982.89 12.10 467 133122 14447 90480411
Blood prolactin abnormal 957.22 12.10 303 133286 2963 90491895
Sexual dysfunction 945.21 12.10 330 133259 4474 90490384
Agitation 871.97 12.10 751 132838 66347 90428511
Psychotic disorder 863.77 12.10 551 133038 30679 90464179
Intentional self-injury 862.52 12.10 538 133051 28796 90466062
Somnolence 861.48 12.10 1285 132304 207799 90287059
Drug interaction 860.21 12.10 1495 132094 274958 90219900
Drug abuse 844.91 12.10 807 132782 81540 90413318
Hyperprolactinaemia 839.06 12.10 312 133277 5121 90489737
Dyskinesia 827.34 12.10 569 133020 35965 90458893
Anosognosia 826.12 12.10 276 133313 3246 90491612
Parkinsonism 775.68 12.10 390 133199 13675 90481183
Completed suicide 769.63 12.10 1007 132582 144051 90350807
Disturbance in social behaviour 737.69 12.10 265 133324 3923 90490935
Metabolic disorder 726.02 12.10 307 133282 7163 90487695
Hallucination, auditory 689.75 12.10 376 133213 15599 90479259
Overdose 661.71 12.10 978 132611 156731 90338127
Delusion 657.12 12.10 347 133242 13493 90481365
Catatonia 642.70 12.10 265 133324 5791 90489067
Tardive dyskinesia 614.26 12.10 307 133282 10623 90484235
Schizoaffective disorder 603.72 12.10 242 133347 4905 90489953
Suicidal ideation 598.28 12.10 637 132952 73218 90421640
Personality change 591.09 12.10 264 133325 7057 90487801
Coma 571.69 12.10 617 132972 72015 90422843
Pain 564.58 12.10 391 133198 995950 89498908
Arthralgia 546.23 12.10 233 133356 778289 89716569
Post-injection delirium sedation syndrome 522.94 12.10 100 133489 34 90494824
Depressed level of consciousness 505.20 12.10 579 133010 72205 90422653
Hypomania 476.80 12.10 242 133347 8655 90486203
Arthropathy 468.58 12.10 16 133573 366226 90128632
Joint swelling 467.88 12.10 88 133501 503212 89991646
Infusion related reaction 455.57 12.10 44 133545 416736 90078122
Aggression 446.20 12.10 346 133243 26322 90468536
Rheumatoid arthritis 427.86 12.10 27 133562 362587 90132271
Mania 425.08 12.10 263 133326 13861 90480997
Metabolic syndrome 423.63 12.10 143 133446 1739 90493119
Treatment noncompliance 420.32 12.10 447 133142 51280 90443578
Salivary hypersecretion 411.98 12.10 221 133368 8871 90485987
Muscle rigidity 411.86 12.10 259 133330 14050 90480808
Diabetes mellitus 392.19 12.10 481 133108 64394 90430464
Glossodynia 391.76 12.10 20 133569 321759 90173099
Hypersensitivity 383.10 12.10 99 133490 454578 90040280
Pleurothotonus 371.18 12.10 119 133470 1216 90493642
Abdominal discomfort 370.86 12.10 121 133468 477207 90017651
Swelling 369.18 12.10 83 133506 418975 90075883
Drug level increased 367.05 12.10 314 133275 27448 90467410
Tachycardia 365.62 12.10 753 132836 156920 90337938
Weight increased 361.05 12.10 1392 132197 416535 90078323
Sinusitis 352.65 12.10 45 133544 343043 90151815
Alopecia 345.29 12.10 149 133440 494922 89999936
Hypothermia 341.72 12.10 238 133351 15337 90479521
Systemic lupus erythematosus 338.84 12.10 62 133527 361834 90133024
Restlessness 337.84 12.10 335 133254 35385 90459473
Tremor 332.41 12.10 712 132877 152461 90342397
Oculogyric crisis 330.90 12.10 128 133461 2351 90492507
Nasopharyngitis 329.10 12.10 96 133493 407008 90087850
Contraindicated product administered 319.48 12.10 46 133543 320093 90174765
Drug hypersensitivity 319.36 12.10 142 133447 463467 90031391
Duodenal ulcer perforation 309.51 12.10 3 133586 221285 90273573
Rash 298.98 12.10 445 133144 795655 89699203
Pruritus 295.95 12.10 220 133369 541305 89953553
Hallucination 295.11 12.10 422 133167 65537 90429321
Headache 288.81 12.10 520 133069 862226 89632632
Psoriatic arthropathy 284.96 12.10 12 133577 228323 90266535
Abnormal behaviour 283.08 12.10 248 133341 22380 90472478
Psychomotor hyperactivity 281.58 12.10 196 133393 12617 90482241
Blood prolactin increased 277.21 12.10 126 133463 3511 90491347
Miosis 276.29 12.10 173 133416 9311 90485547
Peripheral swelling 275.97 12.10 132 133457 412974 90081884
Blood glucose increased 269.61 12.10 495 133094 94751 90400107
Folliculitis 268.21 12.10 7 133582 204346 90290512
Psychotic symptom 267.79 12.10 107 133482 2149 90492709
Fatigue 266.20 12.10 847 132742 1153176 89341682
Mental impairment 260.42 12.10 208 133381 16512 90478346
Discomfort 256.70 12.10 47 133542 274288 90220570
Jaundice cholestatic 252.55 12.10 167 133422 9876 90484982
Blister 251.22 12.10 38 133551 254960 90239898
Rhabdomyolysis 250.23 12.10 342 133247 50914 90443944
Drug intolerance 248.13 12.10 179 133410 447412 90047446
Galactorrhoea 247.18 12.10 126 133463 4546 90490312
Urticaria 244.95 12.10 78 133511 312656 90182202
Neutropenia 240.64 12.10 804 132785 224100 90270758
Dyspnoea 235.60 12.10 602 132987 880353 89614505
Persecutory delusion 234.65 12.10 108 133481 3100 90491758
Irritable bowel syndrome 234.30 12.10 19 133570 207429 90287429
Myocarditis 232.82 12.10 180 133409 13626 90481232
Paranoia 232.43 12.10 175 133414 12733 90482125
Pericarditis 230.84 12.10 57 133532 270094 90224764
Serotonin syndrome 230.68 12.10 282 133307 37605 90457253
Therapeutic product effect decreased 221.36 12.10 67 133522 277504 90217354
Stomatitis 219.62 12.10 66 133523 274632 90220226
Wound 219.42 12.10 86 133503 302894 90191964
Fibromyalgia 219.40 12.10 24 133565 206245 90288613
Febrile neutropenia 217.71 12.10 618 132971 157731 90337127
Orthostatic hypertension 216.84 12.10 65 133524 520 90494338
Impaired healing 215.09 12.10 42 133547 234157 90260701
Muscle injury 208.66 12.10 13 133576 176641 90318217
Pain in extremity 207.38 12.10 215 133374 450314 90044544
Social avoidant behaviour 207.02 12.10 101 133488 3312 90491546
Blood creatine phosphokinase increased 206.75 12.10 253 133336 33770 90461088
Cardio-respiratory arrest 205.60 12.10 349 133240 62791 90432067
Osteoarthritis 205.09 12.10 24 133565 195706 90299152
Antipsychotic drug level increased 203.09 12.10 103 133486 3676 90491182
Psychiatric decompensation 199.32 12.10 83 133506 1860 90492998
Gestational diabetes 198.43 12.10 147 133442 10435 90484423
Gastrointestinal disorder 195.74 12.10 67 133522 256620 90238238
Pneumonia aspiration 187.60 12.10 265 133324 40675 90454183
Psychomotor retardation 185.56 12.10 105 133484 4684 90490174
Mobility decreased 183.45 12.10 70 133519 250664 90244194
Dysarthria 181.17 12.10 304 133285 54178 90440680
Joint range of motion decreased 180.44 12.10 4 133585 135639 90359219
Bradyphrenia 180.39 12.10 122 133467 7490 90487368
Hyperthermia 174.82 12.10 135 133454 10200 90484658
Cholelithiasis 174.62 12.10 293 133296 52213 90442645
Respiratory depression 173.67 12.10 160 133429 15415 90479443
Diarrhoea 170.70 12.10 759 132830 938431 89556427
Sleep disorder due to general medical condition, insomnia type 170.39 12.10 4 133585 128690 90366168
Arthritis 166.90 12.10 24 133565 167291 90327567
Amenorrhoea 166.07 12.10 138 133451 11584 90483274
Lower respiratory tract infection 165.86 12.10 81 133508 250578 90244280
Pulmonary embolism 165.78 12.10 496 133093 130324 90364534
Disorientation 164.12 12.10 259 133330 43855 90451003
Asthma 163.69 12.10 76 133513 242084 90252774
Camptocormia 159.89 12.10 44 133545 249 90494609
Hypoaesthesia 158.46 12.10 138 133451 314072 90180786
Infection 155.31 12.10 183 133406 361911 90132947
Bursitis 154.53 12.10 10 133579 131644 90363214
Inflammation 153.84 12.10 37 133552 178555 90316303
Seizure 153.79 12.10 535 133054 152094 90342764
Injury 151.32 12.10 51 133538 197298 90297560
Injection site pain 149.59 12.10 36 133553 173663 90321195
Posture abnormal 148.93 12.10 75 133514 2636 90492222
C-reactive protein abnormal 148.62 12.10 10 133579 127419 90367439
Delirium 146.99 12.10 411 133178 103948 90390910
Leukopenia 145.18 12.10 400 133189 100310 90394548
Mental disorder 144.84 12.10 207 133382 32111 90462747
Intentional product use issue 143.62 12.10 70 133519 216822 90278036
Obsessive-compulsive disorder 143.51 12.10 87 133502 4417 90490441
Treatment failure 143.20 12.10 142 133447 303786 90191072
Cardiac arrest 142.65 12.10 408 133181 104527 90390331
Asthma-chronic obstructive pulmonary disease overlap syndrome 141.78 12.10 89 133500 4810 90490048
Apathy 140.08 12.10 122 133467 10918 90483940
Liver injury 139.91 12.10 39 133550 170528 90324330
Blood bilirubin increased 139.81 12.10 239 133350 43231 90451627
Total lung capacity increased 139.77 12.10 89 133500 4932 90489926
Increased appetite 137.31 12.10 124 133465 11641 90483217
Musculoskeletal pain 137.08 12.10 41 133548 171210 90323648
Wound infection 134.70 12.10 5 133584 106397 90388461
Lip dry 134.18 12.10 3 133586 100952 90393906
Musculoskeletal stiffness 133.53 12.10 144 133445 296388 90198470
Disturbance in attention 133.45 12.10 245 133344 46864 90447994
Sciatica 131.04 12.10 4 133585 101378 90393480
Sinus tachycardia 128.32 12.10 183 133406 28330 90466528
Ill-defined disorder 128.10 12.10 56 133533 184835 90310023
Antipsychotic drug level above therapeutic 124.96 12.10 54 133535 1330 90493528
Hallucinations, mixed 124.53 12.10 88 133501 5801 90489057
Substance abuse 124.20 12.10 85 133504 5321 90489537
Respiratory arrest 123.11 12.10 195 133394 33116 90461742
Mutism 121.44 12.10 57 133532 1712 90493146
Dyspepsia 120.86 12.10 71 133518 198089 90296769
Hyponatraemia 120.83 12.10 452 133137 133086 90361772
Unresponsive to stimuli 120.50 12.10 208 133381 37913 90456945
Irritability 119.90 12.10 200 133389 35462 90459396
Anxiety 119.56 12.10 824 132765 308948 90185910
Blood triglycerides increased 119.01 12.10 123 133466 13638 90481220
Back pain 118.92 12.10 177 133412 316998 90177860
Grip strength decreased 118.41 12.10 4 133585 92572 90402286
Generalised tonic-clonic seizure 117.69 12.10 196 133393 34707 90460151
Hallucination, visual 117.11 12.10 157 133432 22935 90471923
Psychiatric symptom 116.10 12.10 91 133498 7027 90487831
Night sweats 114.23 12.10 25 133564 128741 90366117
Torsade de pointes 114.17 12.10 126 133463 15056 90479802
Polydipsia 112.84 12.10 73 133516 4158 90490700
Poisoning 112.21 12.10 125 133464 15092 90479766
Abdominal pain upper 110.42 12.10 201 133388 332473 90162385
Bipolar disorder 109.41 12.10 97 133492 8888 90485970
Pulmonary fibrosis 108.18 12.10 15 133574 107488 90387370
Cough 107.06 12.10 241 133348 368721 90126137
Urinary retention 106.53 12.10 196 133393 37548 90457310
Cogwheel rigidity 106.31 12.10 55 133534 2047 90492811
Altered state of consciousness 106.22 12.10 177 133412 31355 90463503
Poisoning deliberate 105.71 12.10 126 133463 16360 90478498
Loss of consciousness 105.44 12.10 448 133141 139790 90355068
Dyslipidaemia 105.32 12.10 100 133489 10007 90484851
Lung disorder 104.44 12.10 45 133544 149838 90345020
Contusion 104.44 12.10 130 133459 251086 90243772
Granulocytopenia 104.31 12.10 82 133507 6359 90488499
Impulse-control disorder 104.28 12.10 43 133546 939 90493919
Thinking abnormal 103.51 12.10 106 133483 11626 90483232
Peripheral venous disease 102.71 12.10 5 133584 83916 90410942
Bradykinesia 102.63 12.10 83 133506 6705 90488153
Hyperglycaemia 102.56 12.10 230 133359 50740 90444118
Product dose omission issue 102.47 12.10 170 133419 291517 90203341
Sinus rhythm 102.43 12.10 47 133542 1339 90493519
Muscle spasms 101.96 12.10 133 133456 251750 90243108
Eosinophil count decreased 99.66 12.10 61 133528 3151 90491707
Diabetic coma 97.92 12.10 38 133551 704 90494154
Paraesthesia 96.45 12.10 137 133452 250189 90244669
Cognitive disorder 95.40 12.10 271 133318 69136 90425722
Wheezing 93.02 12.10 129 133460 237951 90256907
Knee arthroplasty 92.83 12.10 8 133581 83174 90411684
Refusal of examination 92.24 12.10 27 133562 197 90494661
Myoclonus 92.17 12.10 127 133462 19041 90475817
Lower limb fracture 90.08 12.10 10 133579 85003 90409855
Psoriasis 89.99 12.10 53 133536 147701 90347157
Sarcoidosis 89.79 12.10 94 133495 10579 90484279
Affective disorder 88.72 12.10 81 133508 7712 90487146
Screaming 88.61 12.10 60 133529 3690 90491168
Neutrophil count decreased 87.54 12.10 268 133321 71264 90423594
Inappropriate antidiuretic hormone secretion 87.49 12.10 125 133464 19380 90475478
Hypertonia 86.45 12.10 67 133522 5088 90489770
Hepatocellular injury 86.33 12.10 154 133435 28804 90466054
Hip arthroplasty 85.95 12.10 7 133582 76201 90418657
Injection site erythema 85.61 12.10 20 133569 98482 90396376
Speech disorder 85.41 12.10 200 133389 45385 90449473
Obsessive-compulsive symptom 85.22 12.10 22 133567 93 90494765
White blood cell count decreased 84.10 12.10 476 133113 166633 90328225
Hyperammonaemic encephalopathy 83.09 12.10 51 133538 2648 90492210
Hepatotoxicity 82.50 12.10 198 133391 45644 90449214
Chest discomfort 80.98 12.10 52 133537 138313 90356545
Negativism 80.42 12.10 29 133560 434 90494424
Maternal exposure during pregnancy 79.88 12.10 268 133321 359795 90135063
Nasal polyps 79.58 12.10 89 133500 10791 90484067
Autoimmune disorder 78.90 12.10 10 133579 76734 90418124
Migraine 78.61 12.10 99 133490 190293 90304565
Injection site reaction 77.48 12.10 20 133569 92060 90402798
Osteoporosis 77.43 12.10 23 133566 96508 90398350
Personality change due to a general medical condition 77.15 12.10 25 133564 265 90494593
Drooling 76.05 12.10 59 133530 4487 90490371
Chest pain 75.73 12.10 231 133358 319414 90175444
Head titubation 75.34 12.10 37 133552 1231 90493627
Accidental death 74.25 12.10 43 133546 2005 90492853
Nail disorder 73.99 12.10 3 133586 59064 90435794
Euphoric mood 73.15 12.10 62 133527 5347 90489511
Self-injurious ideation 72.73 12.10 50 133539 3153 90491705
Cardiac murmur 72.10 12.10 110 133479 18084 90476774
Gait inability 71.75 12.10 66 133523 146390 90348468
Mydriasis 71.48 12.10 99 133490 14913 90479945
Neck pain 70.65 12.10 40 133549 113923 90380935
Food craving 70.52 12.10 41 133548 1926 90492932
Intentional product misuse 70.25 12.10 290 133299 89314 90405544
Withdrawal syndrome 70.01 12.10 122 133467 22402 90472456
Refusal of treatment by patient 69.97 12.10 62 133527 5676 90489182
Polyuria 69.81 12.10 80 133509 9960 90484898
Acute psychosis 69.77 12.10 48 133541 3030 90491828
Obsessive thoughts 69.27 12.10 28 133561 580 90494278
Drug resistance 67.63 12.10 143 133446 30306 90464552
Anaphylactic reaction 66.39 12.10 23 133566 87501 90407357
Hyperphagia 66.38 12.10 45 133544 2773 90492085
Product use issue 66.24 12.10 256 133333 329663 90165195
Electroencephalogram abnormal 66.01 12.10 52 133537 4044 90490814
Hypotension 65.64 12.10 751 132838 324646 90170212
Exostosis 65.56 12.10 3 133586 53131 90441727
Trimethylaminuria 65.44 12.10 20 133569 172 90494686
Apraxia 65.22 12.10 41 133548 2221 90492637
Rhinitis allergic 64.43 12.10 100 133489 16685 90478173
Confusional state 64.40 12.10 860 132729 385345 90109513
Lung neoplasm malignant 63.46 12.10 122 133467 24151 90470707
Injection site pruritus 63.42 12.10 4 133585 53830 90441028
Depressive symptom 62.26 12.10 56 133533 5229 90489629
Hepatic enzyme increased 61.97 12.10 297 133292 360439 90134419
Erythema 61.46 12.10 156 133433 229090 90265768
Insurance issue 60.99 12.10 78 133511 10880 90483978
Road traffic accident 60.88 12.10 42 133547 107584 90387274
Lethargy 59.83 12.10 217 133372 62922 90431936
Sudden death 59.69 12.10 77 133512 10832 90484026
Adjustment disorder with depressed mood 59.31 12.10 7 133582 56746 90438112
Coma scale abnormal 59.26 12.10 56 133533 5570 90489288
Injection site bruising 58.44 12.10 5 133584 52302 90442556
Diabetic ketoacidosis 58.16 12.10 118 133471 24289 90470569
Illusion 58.03 12.10 31 133558 1233 90493625
Aplastic anaemia 58.00 12.10 84 133505 13185 90481673
Agranulocytosis 57.50 12.10 146 133443 34856 90460002
Somatic symptom disorder of pregnancy 57.21 12.10 16 133573 97 90494761
Depressed mood 56.69 12.10 183 133406 50039 90444819
Stupor 56.66 12.10 54 133535 5428 90489430
Impulsive behaviour 56.62 12.10 34 133555 1696 90493162
Product quality issue 56.56 12.10 23 133566 79302 90415556
Lupus-like syndrome 56.46 12.10 4 133585 48842 90446016
Back injury 56.34 12.10 3 133586 46619 90448239
Psychomotor skills impaired 56.33 12.10 41 133548 2831 90492027
Live birth 56.30 12.10 23 133566 79084 90415774
Alanine aminotransferase increased 56.20 12.10 332 133257 118006 90376852
Megacolon 56.11 12.10 37 133552 2177 90492681
Diet refusal 55.95 12.10 24 133565 580 90494278
Malaise 55.91 12.10 573 133016 585413 89909445
Gamma-glutamyltransferase increased 55.91 12.10 152 133437 37800 90457058
Torticollis 55.89 12.10 39 133550 2519 90492339
Bipolar I disorder 55.71 12.10 36 133553 2046 90492812
Polydipsia psychogenic 55.48 12.10 16 133573 110 90494748
Plasma cell mastitis 55.12 12.10 13 133576 34 90494824
Joint stiffness 55.04 12.10 23 133566 78019 90416839
Myalgia 54.39 12.10 110 133479 175015 90319843
Mental status changes 54.29 12.10 167 133422 44512 90450346
Logorrhoea 53.65 12.10 39 133550 2688 90492170
Muscular weakness 52.83 12.10 144 133445 206522 90288336
Menstruation irregular 52.33 12.10 62 133527 7998 90486860
Abulia 52.26 12.10 24 133565 685 90494173
Flat affect 51.83 12.10 32 133557 1679 90493179
Upper respiratory tract infection 51.64 12.10 68 133521 128250 90366608
Ataxia 51.30 12.10 94 133495 17948 90476910
Laryngitis 51.25 12.10 7 133582 50746 90444112
Behaviour disorder 50.48 12.10 47 133542 4588 90490270
Rebound psychosis 50.41 12.10 17 133572 206 90494652
Exposure during pregnancy 50.20 12.10 555 133034 237855 90257003
Delusion of reference 50.15 12.10 15 133574 119 90494739
Influenza 49.95 12.10 80 133509 139184 90355674
Brain injury 49.38 12.10 59 133530 7679 90487179
Oedema 48.66 12.10 143 133446 200152 90294706
Ear infection 48.51 12.10 21 133568 69754 90425104
Homicide 48.08 12.10 18 133571 301 90494557
Major depression 47.51 12.10 66 133523 9969 90484889
Disease recurrence 46.93 12.10 142 133447 37511 90457347
Neutrophil count increased 46.51 12.10 94 133495 19296 90475562
Foot deformity 46.42 12.10 15 133574 59636 90435222
Abdominal pain 45.97 12.10 368 133221 395353 90099505
Leukocytosis 45.53 12.10 124 133465 30866 90463992
Device expulsion 45.43 12.10 4 133585 40882 90453976
Circulatory collapse 45.27 12.10 108 133481 24796 90470062
Withdrawal catatonia 44.92 12.10 15 133574 176 90494682
Herpes zoster 44.77 12.10 44 133545 94600 90400258
Feeling hot 44.71 12.10 30 133559 77978 90416880
Electrocardiogram QT interval abnormal 44.58 12.10 16 133573 236 90494622
Pressure of speech 44.35 12.10 22 133567 748 90494110
Hypophagia 44.29 12.10 135 133454 35802 90459056
Psychotic disorder due to a general medical condition 44.21 12.10 16 133573 242 90494616
Brain stem thrombosis 44.17 12.10 8 133581 0 90494858
Prescribed underdose 44.15 12.10 28 133561 74991 90419867
Arrhythmia 43.99 12.10 150 133439 42182 90452676
Eosinophilia 43.76 12.10 116 133473 28417 90466441
General physical health deterioration 43.70 12.10 325 133264 354790 90140068
Apallic syndrome 43.66 12.10 22 133567 774 90494084
Asphyxia 43.43 12.10 53 133536 7050 90487808
Blood cholesterol increased 43.28 12.10 159 133430 207853 90287005
Self esteem decreased 43.15 12.10 22 133567 794 90494064
Head banging 42.79 12.10 18 133571 414 90494444
Movement disorder 42.52 12.10 116 133473 28903 90465955
Anticholinergic syndrome 42.44 12.10 34 133555 2709 90492149
White blood cell count increased 42.41 12.10 204 133385 67037 90427821
Hypoglycaemia 41.98 12.10 209 133380 69639 90425219
Encephalitis autoimmune 41.78 12.10 30 133559 2028 90492830
Hypotonia neonatal 41.43 12.10 26 133563 1404 90493454
Grandiosity 41.40 12.10 16 133573 293 90494565
Symptom recurrence 40.92 12.10 39 133550 3920 90490938
Eosinophil count increased 40.84 12.10 71 133518 13010 90481848
Myocardial reperfusion injury 40.71 12.10 13 133576 131 90494727
Hypernatraemia 40.41 12.10 59 133530 9328 90485530
Drug withdrawal syndrome 40.29 12.10 113 133476 28610 90466248
Foetal exposure during pregnancy 40.12 12.10 147 133442 42828 90452030
Illness 40.06 12.10 37 133552 81932 90412926
Embolism venous 39.99 12.10 37 133552 3583 90491275
Urinary incontinence 39.82 12.10 134 133455 37432 90457426
Muscle twitching 39.80 12.10 101 133488 24101 90470757
Weight decreased 39.77 12.10 363 133226 379547 90115311
Bronchitis 39.49 12.10 106 133483 152821 90342037
Blunted affect 39.47 12.10 15 133574 262 90494596
Breast enlargement 38.91 12.10 27 133562 1728 90493130
Drug reaction with eosinophilia and systemic symptoms 38.86 12.10 145 133444 42613 90452245
Hypokinesia 38.73 12.10 77 133512 15620 90479238
Bronchiectasis 38.62 12.10 95 133494 22235 90472623
Stereotypy 38.59 12.10 17 133572 439 90494419
Dyspnoea exertional 38.55 12.10 30 133559 72258 90422600
Throat irritation 38.33 12.10 12 133577 48683 90446175
Bone pain 38.06 12.10 22 133567 61961 90432897
Adverse event 37.97 12.10 72 133517 117346 90377512
Negative symptoms in schizophrenia 37.75 12.10 12 133577 119 90494739
Colitis ulcerative 37.56 12.10 21 133568 60245 90434613
Electrocardiogram T wave inversion 37.54 12.10 36 133553 3647 90491211
Gynaecomastia 37.46 12.10 14 133575 233 90494625
Thermal burn 37.42 12.10 48 133541 6714 90488144
Sluggishness 37.31 12.10 45 133544 5914 90488944
Hypoxic-ischaemic encephalopathy 37.29 12.10 40 133549 4628 90490230
Tachypnoea 37.22 12.10 91 133498 21218 90473640
Phagophobia 37.21 12.10 10 133579 51 90494807
Bicytopenia 36.82 12.10 36 133553 3735 90491123
Frequent bowel movements 36.72 12.10 19 133570 56916 90437942
Flushing 36.52 12.10 46 133543 88445 90406413
Sleep disorder 36.37 12.10 159 133430 197871 90296987
Food refusal 36.15 12.10 18 133571 617 90494241
Ear pain 36.12 12.10 20 133569 57682 90437176
Ventricular fibrillation 35.99 12.10 70 133519 13974 90480884
Cataract 35.88 12.10 32 133557 72060 90422798
Nasal congestion 35.87 12.10 42 133547 83372 90411486
Breast discomfort 35.70 12.10 18 133571 634 90494224
Cor pulmonale acute 35.70 12.10 16 133573 431 90494427
Hypotonia 35.65 12.10 62 133527 11364 90483494
Walking aid user 35.60 12.10 5 133584 35501 90459357
Ketosis-prone diabetes mellitus 35.41 12.10 8 133581 16 90494842
Myocardial hypoxia 35.41 12.10 8 133581 16 90494842
Hepatic cirrhosis 35.35 12.10 25 133564 63228 90431630
Communication disorder 35.34 12.10 33 133556 3233 90491625
Suspected suicide 35.33 12.10 56 133533 9512 90485346
Distractibility 35.28 12.10 17 133572 542 90494316
Therapy partial responder 35.22 12.10 91 133498 21952 90472906
Trichoglossia 35.16 12.10 16 133573 447 90494411
Dry mouth 34.90 12.10 146 133443 183913 90310945
Sedation complication 34.68 12.10 77 133512 16867 90477991
Substance-induced psychotic disorder 34.59 12.10 31 133558 2881 90491977
Ileus paralytic 34.48 12.10 40 133549 5045 90489813
Macular degeneration 34.43 12.10 7 133582 37963 90456895
Parkinsonian gait 34.35 12.10 17 133572 575 90494283
Injection site swelling 34.31 12.10 23 133566 59816 90435042
Hypercholesterolaemia 34.29 12.10 60 133529 100832 90394026
Skin exfoliation 33.97 12.10 30 133559 67883 90426975
Osteonecrosis of jaw 33.85 12.10 8 133581 39095 90455763
Hallucination, olfactory 33.77 12.10 14 133575 310 90494548
Accidental overdose 33.72 12.10 105 133484 28168 90466690
Monocyte count decreased 33.61 12.10 29 133560 2562 90492296
Hepatic cytolysis 33.41 12.10 111 133478 30805 90464053
Skin ulcer 33.36 12.10 16 133573 50059 90444799
Joint dislocation 33.32 12.10 12 133577 44570 90450288
Suicidal behaviour 33.23 12.10 30 133559 2814 90492044
Oral herpes 32.97 12.10 5 133584 33519 90461339
Waxy flexibility 32.87 12.10 11 133578 130 90494728
Discoloured vomit 32.86 12.10 21 133568 1171 90493687
Basal cell carcinoma 32.79 12.10 5 133584 33384 90461474
Adverse reaction 32.76 12.10 3 133586 29709 90465149
Procedural pain 32.75 12.10 5 133584 33355 90461503
Central nervous system lupus 32.66 12.10 22 133567 1341 90493517
Haemoglobin urine 32.64 12.10 11 133578 133 90494725
Somnambulism 32.58 12.10 43 133546 6185 90488673
Ventricular tachycardia 32.51 12.10 95 133494 24613 90470245
Depression 32.51 12.10 623 132966 299978 90194880
Corticobasal degeneration 32.45 12.10 7 133582 10 90494848
Feeling guilty 32.41 12.10 17 133572 651 90494207
Haematochezia 32.36 12.10 34 133555 70879 90423979
Aspartate aminotransferase increased 32.34 12.10 261 133328 102676 90392182
Bezoar 32.27 12.10 29 133560 2705 90492153
Renal tubular acidosis 32.26 12.10 27 133562 2288 90492570
Bradycardia 32.24 12.10 223 133366 83624 90411234
Respiratory dyskinesia 32.12 12.10 9 133580 55 90494803
Hypertension 32.02 12.10 478 133111 457054 90037804
Reduced facial expression 31.96 12.10 28 133561 2525 90492333
Immunodeficiency 31.70 12.10 12 133577 43222 90451636
Onychomycosis 31.67 12.10 8 133581 37368 90457490
Water intoxication 31.44 12.10 16 133573 575 90494283
Fluid retention 31.21 12.10 51 133538 88040 90406818
Oromandibular dystonia 31.14 12.10 16 133573 587 90494271
Liver function test increased 31.13 12.10 48 133541 84807 90410051
Diabetic hyperosmolar coma 31.07 12.10 14 133575 382 90494476
Nausea 31.07 12.10 1330 132259 1108986 89385872
Taste disorder 31.01 12.10 27 133562 61519 90433339
Condition aggravated 30.91 12.10 1120 132469 594425 89900433
Abnormal clotting factor 30.69 12.10 10 133579 108 90494750
Rash pruritic 30.65 12.10 46 133543 82168 90412690
Disorganised speech 30.53 12.10 24 133565 1861 90492997
Bradypnoea 30.52 12.10 36 133553 4622 90490236
Antipsychotic drug level decreased 30.51 12.10 14 133575 399 90494459
Hypersomnia 30.49 12.10 85 133504 21446 90473412
Distributive shock 30.32 12.10 31 133558 3393 90491465
Self-medication 30.06 12.10 30 133559 3190 90491668
Blepharospasm 29.58 12.10 23 133566 55422 90439436
Butterfly rash 29.45 12.10 25 133564 2160 90492698
Tobacco interaction 29.29 12.10 9 133580 79 90494779
Thought blocking 29.22 12.10 11 133578 187 90494671
Myoclonic epilepsy 29.16 12.10 22 133567 1605 90493253
Coma scale 29.11 12.10 8 133581 45 90494813
Bundle branch block right 29.07 12.10 38 133551 5415 90489443
Pharyngeal dystonia 28.98 12.10 6 133583 6 90494852
Drug tolerance decreased 28.97 12.10 6 133583 32124 90462734
Asthenia 28.87 12.10 584 133005 533167 89961691
Chronic obstructive pulmonary disease 28.77 12.10 197 133392 73632 90421226
Neoplasm progression 28.46 12.10 15 133574 44471 90450387
Autonomic nervous system imbalance 28.33 12.10 30 133559 3420 90491438
Anaphylactic shock 28.31 12.10 6 133583 31611 90463247
Pre-eclampsia 28.23 12.10 55 133534 10993 90483865
Red blood cell sedimentation rate increased 28.17 12.10 49 133540 82546 90412312
Hepatic function abnormal 28.16 12.10 139 133450 46149 90448709
Sneezing 28.16 12.10 5 133584 29864 90464994
Akinesia 27.89 12.10 22 133567 1714 90493144
Suspiciousness 27.77 12.10 13 133576 388 90494470
Hypersexuality 27.75 12.10 15 133574 611 90494247
Ventricular arrhythmia 27.66 12.10 33 133556 4288 90490570
Neuropathy peripheral 27.63 12.10 106 133483 136864 90357994
Impaired self-care 27.60 12.10 22 133567 1740 90493118
Blood pressure increased 27.45 12.10 174 133415 197043 90297815
Hyperreflexia 27.44 12.10 41 133548 6616 90488242
Oral candidiasis 27.44 12.10 9 133580 35446 90459412
Disinhibition 27.43 12.10 18 133571 1050 90493808
Sleep disorder due to a general medical condition 27.30 12.10 16 133573 44722 90450136
Sinus bradycardia 27.10 12.10 70 133519 16882 90477976
Loss of personal independence in daily activities 27.03 12.10 106 133483 135999 90358859
Dysphoria 26.95 12.10 39 133550 6115 90488743
Consciousness fluctuating 26.91 12.10 17 133572 929 90493929
Toxic encephalopathy 26.88 12.10 47 133542 8652 90486206
Labelled drug-drug interaction issue 26.74 12.10 24 133565 2234 90492624
Selective eating disorder 26.68 12.10 23 133566 2030 90492828
Wound complication 26.66 12.10 34 133555 4729 90490129
Ideas of reference 26.54 12.10 9 133580 111 90494747
Delusional disorder, unspecified type 26.46 12.10 13 133576 433 90494425
Paraesthesia oral 26.39 12.10 7 133582 31652 90463206
Wrong patient received product 26.39 12.10 29 133560 3448 90491410
Type 1 diabetes mellitus 26.38 12.10 34 133555 4778 90490080
Liver disorder 26.34 12.10 91 133498 121178 90373680
COVID-19 26.13 12.10 144 133445 168699 90326159
Long QT syndrome 26.12 12.10 31 133558 4006 90490852
Delusion of grandeur 25.91 12.10 11 133578 259 90494599
Flight of ideas 25.81 12.10 13 133576 457 90494401
Device issue 25.65 12.10 6 133583 29531 90465327
High density lipoprotein decreased 25.31 12.10 25 133564 2626 90492232
Injection site rash 25.21 12.10 3 133586 24170 90470688
Abnormal weight gain 25.20 12.10 25 133564 2640 90492218
Acquired haemophilia 25.01 12.10 17 133572 1052 90493806
Haematocrit decreased 25.01 12.10 125 133464 41707 90453151
Fungal infection 24.99 12.10 16 133573 42645 90452213
Hyporesponsive to stimuli 24.93 12.10 20 133569 1597 90493261
Fear 24.91 12.10 67 133522 16555 90478303
Troponin T increased 24.86 12.10 20 133569 1603 90493255
Oropharyngeal spasm 24.73 12.10 11 133578 291 90494567
Pulmonary mass 24.68 12.10 6 133583 28766 90466092
Hyperlipidaemia 24.51 12.10 82 133507 22834 90472024
Hot flush 24.47 12.10 31 133558 59457 90435401
Intellectual disability 24.41 12.10 18 133571 1268 90493590
Staring 24.36 12.10 20 133569 1650 90493208
Device dislocation 24.35 12.10 8 133581 31474 90463384
Colitis ischaemic 24.03 12.10 55 133534 12291 90482567
International normalised ratio abnormal 24.01 12.10 29 133560 3816 90491042
Rectal haemorrhage 23.99 12.10 54 133535 82690 90412168
Multiple sclerosis relapse 23.95 12.10 25 133564 52280 90442578
Malignant catatonia 23.93 12.10 10 133579 226 90494632
Influenza like illness 23.87 12.10 52 133537 80559 90414299
Hypoventilation 23.84 12.10 34 133555 5262 90489596
Mean cell haemoglobin concentration decreased 23.83 12.10 31 133558 4397 90490461
Bone disorder 23.79 12.10 3 133586 23117 90471741
Electrocardiogram J wave 23.67 12.10 5 133584 6 90494852
Seasonal allergy 23.61 12.10 3 133586 22980 90471878
Respiratory disorder 23.45 12.10 37 133552 64779 90430079
Oropharyngeal pain 23.33 12.10 89 133500 115098 90379760
Meige's syndrome 23.24 12.10 5 133584 7 90494851
Hypercapnia 23.18 12.10 38 133551 6639 90488219
Freezing phenomenon 22.94 12.10 20 133569 1792 90493066
Alcohol abuse 22.89 12.10 21 133568 2012 90492846
Electrocardiogram J wave abnormal 22.84 12.10 5 133584 8 90494850
Palmoplantar keratoderma 22.80 12.10 27 133562 3480 90491378
Violence-related symptom 22.61 12.10 13 133576 598 90494260
Petit mal epilepsy 22.57 12.10 32 133557 4926 90489932
Flank pain 22.56 12.10 71 133518 19151 90475707
Drug withdrawal syndrome neonatal 22.38 12.10 22 133567 2297 90492561
Hypertriglyceridaemia 22.30 12.10 41 133548 7848 90487010
Surgery 22.24 12.10 20 133569 44867 90449991
Blood alkaline phosphatase increased 22.24 12.10 134 133455 47945 90446913
Retinal coloboma 22.10 12.10 6 133583 32 90494826
Cytomegalovirus infection 21.95 12.10 6 133583 26596 90468262
Insomnia 21.88 12.10 645 132944 332829 90162029
Acidosis 21.83 12.10 54 133535 12682 90482176
Troponin abnormal 21.79 12.10 7 133582 72 90494786
Tension 21.75 12.10 27 133562 3655 90491203
Disability 21.61 12.10 17 133572 40728 90454130
Differential white blood cell count abnormal 21.58 12.10 15 133574 963 90493895
Analgesic drug level increased 21.56 12.10 24 133565 2895 90491963
Compulsions 21.52 12.10 9 133580 204 90494654
Methaemoglobinaemia 21.44 12.10 28 133561 3987 90490871
Limb discomfort 21.32 12.10 15 133574 38045 90456813
Red blood cells urine 21.31 12.10 12 133577 530 90494328
Product label confusion 21.16 12.10 4 133585 22846 90472012
Respiratory tract congestion 21.14 12.10 7 133582 27403 90467455
Respiratory tract infection 21.12 12.10 34 133555 59044 90435814
Rash erythematous 20.97 12.10 40 133549 65064 90429794
Clonic convulsion 20.90 12.10 14 133575 846 90494012
Insulin C-peptide increased 20.89 12.10 7 133582 83 90494775
Iris coloboma 20.84 12.10 6 133583 41 90494817
Eosinophil count abnormal 20.81 12.10 14 133575 852 90494006
Flashback 20.81 12.10 10 133579 317 90494541
Nephrolithiasis 20.79 12.10 25 133564 49060 90445798
Back disorder 20.74 12.10 6 133583 25625 90469233
Psychogenic visual disorder 20.70 12.10 5 133584 15 90494843
Echolalia 20.63 12.10 10 133579 323 90494535
Resting tremor 20.56 12.10 14 133575 869 90493989
Localised infection 20.48 12.10 12 133577 33550 90461308
Ventricular dyskinesia 20.43 12.10 8 133581 152 90494706
Pulse absent 20.40 12.10 34 133555 6021 90488837
Drug monitoring procedure incorrectly performed 20.35 12.10 10 133579 333 90494525
Haemorrhoids 20.28 12.10 7 133582 26695 90468163
Eczema 20.27 12.10 29 133560 52841 90442017
Gastrointestinal sounds abnormal 20.20 12.10 29 133560 4514 90490344
Electrocardiogram abnormal 20.18 12.10 46 133543 10252 90484606
Alcohol poisoning 20.08 12.10 19 133570 1893 90492965
Rhinorrhoea 20.05 12.10 65 133524 88251 90406607
Somatic symptom disorder 19.95 12.10 25 133564 3416 90491442
White blood cells urine positive 19.94 12.10 35 133554 6463 90488395
Cardiospasm 19.92 12.10 25 133564 3421 90491437
Transient aphasia 19.91 12.10 6 133583 49 90494809
Slow speech 19.90 12.10 19 133570 1914 90492944
Postural tremor 19.76 12.10 11 133578 475 90494383
Muscle spasticity 19.68 12.10 14 133575 35308 90459550
Ketoacidosis 19.64 12.10 32 133557 5563 90489295
Locked-in syndrome 19.64 12.10 11 133578 481 90494377
Grimacing 19.49 12.10 11 133578 488 90494370
Emotional distress 19.46 12.10 106 133483 36556 90458302
Caesarean section 19.45 12.10 66 133523 18511 90476347
Skin discolouration 19.39 12.10 22 133567 44293 90450565
Delusional disorder, erotomanic type 19.20 12.10 6 133583 56 90494802
Sleep terror 19.13 12.10 28 133561 4436 90490422
Stress 19.12 12.10 59 133530 81336 90413522
Hostility 19.08 12.10 20 133569 2253 90492605
Syncope 19.08 12.10 288 133301 132375 90362483
Clonus 18.99 12.10 32 133557 5718 90489140
Incontinence 18.98 12.10 53 133536 13382 90481476
Feelings of worthlessness 18.95 12.10 10 133579 388 90494470
Nephropathy 18.94 12.10 42 133547 9193 90485665
Pupillary reflex impaired 18.92 12.10 21 133568 2524 90492334
Affect lability 18.76 12.10 64 133525 17999 90476859
Paroxysmal perceptual alteration 18.65 12.10 6 133583 62 90494796
Wrong drug 18.62 12.10 9 133580 289 90494569
Chills 18.59 12.10 116 133473 131865 90362993
Gaze palsy 18.57 12.10 17 133572 1624 90493234
Cyanosis 18.54 12.10 67 133522 19388 90475470
Hepatitis toxic 18.39 12.10 25 133564 3700 90491158
Brain death 18.37 12.10 26 133563 3995 90490863
Borderline personality disorder 18.31 12.10 14 133575 1042 90493816
Anger 18.29 12.10 53 133536 13667 90481191
Compartment syndrome 18.25 12.10 22 133567 2890 90491968
Tic 18.20 12.10 18 133571 1893 90492965
Muscle contractions involuntary 18.15 12.10 22 133567 2906 90491952
Encephalopathy 18.13 12.10 124 133465 46320 90448538
Joint injury 18.13 12.10 13 133576 32651 90462207
Cerebral atrophy 18.09 12.10 31 133558 5615 90489243
Hospitalisation 18.00 12.10 277 133312 127823 90367035
Product substitution issue 18.00 12.10 63 133526 17945 90476913
Disease progression 17.99 12.10 146 133443 156469 90338389
Cyanosis neonatal 17.94 12.10 10 133579 433 90494425
Tubo-ovarian abscess 17.92 12.10 10 133579 434 90494424
Alcohol use 17.91 12.10 17 133572 1700 90493158
Body mass index increased 17.91 12.10 16 133573 1481 90493377
Polydactyly 17.88 12.10 9 133580 316 90494542
Dissociation 17.86 12.10 34 133555 6681 90488177
Slow response to stimuli 17.85 12.10 14 133575 1082 90493776
Amylase increased 17.82 12.10 35 133554 7037 90487821
Crying 17.78 12.10 80 133509 25565 90469293
Deep vein thrombosis 17.78 12.10 210 133379 91410 90403448
Antipsychotic drug level below therapeutic 17.75 12.10 9 133580 321 90494537
Orthostatic hypotension 17.74 12.10 114 133475 41713 90453145
Syndactyly 17.70 12.10 11 133578 584 90494274
Radiculopathy 17.66 12.10 3 133586 18502 90476356
Grunting 17.53 12.10 8 133581 225 90494633
Product packaging confusion 17.53 12.10 8 133581 225 90494633
Ileus 17.51 12.10 59 133530 16487 90478371
Anterograde amnesia 17.46 12.10 11 133578 598 90494260
Decreased appetite 17.46 12.10 422 133167 376118 90118740
Injection site haemorrhage 17.46 12.10 10 133579 28308 90466550
Drug level above therapeutic 17.45 12.10 31 133558 5778 90489080
Skin disorder 17.43 12.10 17 133572 36689 90458169
Vasculitis 17.43 12.10 73 133516 22620 90472238
Cystitis 17.40 12.10 46 133543 66672 90428186
Homicidal ideation 17.39 12.10 17 133572 1763 90493095
Constricted affect 17.38 12.10 4 133585 9 90494849
Taciturnity 17.38 12.10 4 133585 9 90494849
Nuchal rigidity 17.38 12.10 12 133577 762 90494096
Therapeutic response shortened 17.37 12.10 6 133583 22873 90471985
Blood pressure diastolic abnormal 17.34 12.10 4 133585 19877 90474981
Tendonitis 17.30 12.10 5 133584 21367 90473491
Productive cough 17.30 12.10 57 133532 77006 90417852
CSF glucose increased 17.26 12.10 5 133584 35 90494823
Areflexia 17.25 12.10 24 133565 3629 90491229
Rash vesicular 17.25 12.10 3 133586 18194 90476664
Patient dissatisfaction with treatment 17.25 12.10 9 133580 341 90494517
Brief psychotic disorder, with postpartum onset 17.14 12.10 5 133584 36 90494822
Morose 17.14 12.10 5 133584 36 90494822
Joint effusion 17.12 12.10 4 133585 19706 90475152
Diverticulitis 17.12 12.10 25 133564 45162 90449696
Cardiac failure congestive 17.06 12.10 81 133508 98613 90396245
Soliloquy 17.03 12.10 9 133580 350 90494508
Dissociative disorder 17.03 12.10 11 133578 625 90494233
Central obesity 16.91 12.10 15 133574 1375 90493483
Limb injury 16.90 12.10 13 133576 31495 90463363
Electrocardiogram QRS complex prolonged 16.89 12.10 35 133554 7313 90487545
Electrocardiogram ST segment abnormal 16.88 12.10 14 133575 1172 90493686
Type 2 diabetes mellitus 16.85 12.10 205 133384 203039 90291819
Mucosal dryness 16.78 12.10 22 133567 3145 90491713
Abdominal distension 16.77 12.10 118 133471 130483 90364375
Drug screen positive 16.73 12.10 24 133565 3733 90491125
Chorea 16.71 12.10 18 133571 2092 90492766
Atrioventricular block first degree 16.66 12.10 38 133551 8473 90486385
Dry eye 16.63 12.10 38 133551 57893 90436965
Mean cell haemoglobin decreased 16.61 12.10 30 133559 5665 90489193
Extensor plantar response 16.57 12.10 15 133574 1412 90493446
Inborn error of metabolism 16.56 12.10 3 133586 0 90494858
Pituitary tumour benign 16.56 12.10 18 133571 2114 90492744
Large for dates baby 16.47 12.10 10 133579 509 90494349
Blood urea decreased 16.40 12.10 20 133569 2658 90492200
Opisthotonus 16.40 12.10 9 133580 378 90494480
Hypokalaemia 16.36 12.10 278 133311 130838 90364020
Drug abuser 16.33 12.10 20 133569 2670 90492188
Toxic leukoencephalopathy 16.33 12.10 12 133577 841 90494017
Microphthalmos 16.33 12.10 7 133582 169 90494689
General physical condition abnormal 16.29 12.10 28 133561 5083 90489775
Pseudohallucination 16.29 12.10 7 133582 170 90494688
Kidney infection 16.19 12.10 9 133580 25907 90468951
Social problem 16.15 12.10 14 133575 1245 90493613
Blood creatinine increased 16.12 12.10 224 133365 101162 90393696
Thrombophlebitis 16.12 12.10 27 133562 4801 90490057
Infarction 16.07 12.10 21 133568 2992 90491866
Pleural effusion 15.99 12.10 98 133491 111893 90382965
Pruritus genital 15.90 12.10 26 133563 4532 90490326
Blood lactic acid increased 15.88 12.10 38 133551 8740 90486118
Ulcer 15.88 12.10 15 133574 32867 90461991
Glutamate dehydrogenase increased 15.87 12.10 5 133584 48 90494810
Tenderness 15.84 12.10 10 133579 26858 90468000
Autism spectrum disorder 15.82 12.10 14 133575 1279 90493579
Hyperthermia malignant 15.78 12.10 14 133575 1284 90493574
Fear-related avoidance of activities 15.78 12.10 7 133582 184 90494674
Unevaluable event 15.73 12.10 36 133553 54812 90440046
Oral pain 15.68 12.10 15 133574 32668 90462190
Posturing 15.67 12.10 10 133579 556 90494302
Neuralgia 15.65 12.10 14 133575 31486 90463372
Myoglobin blood increased 15.50 12.10 15 133574 1537 90493321
Dementia with Lewy bodies 15.49 12.10 9 133580 422 90494436
Potentiating drug interaction 15.47 12.10 29 133560 5633 90489225
Palpitations 15.45 12.10 128 133461 136600 90358258
Helplessness 15.43 12.10 8 133581 299 90494559
Alcoholism 15.40 12.10 16 133573 1784 90493074
Adult failure to thrive 15.40 12.10 7 133582 195 90494663
Bruxism 15.38 12.10 25 133564 4338 90490520
Deafness 15.30 12.10 7 133582 22507 90472351
Metamyelocyte count increased 15.27 12.10 7 133582 199 90494659
Dysuria 15.26 12.10 105 133484 39296 90455562
Eye pain 15.25 12.10 26 133563 44142 90450716
Gastric disorder 15.24 12.10 16 133573 33368 90461490
Sinus disorder 15.18 12.10 17 133572 34430 90460428
Osteonecrosis 15.16 12.10 10 133579 26231 90468627
Intracranial pressure increased 15.14 12.10 32 133557 6779 90488079
Lipids abnormal 15.12 12.10 8 133581 312 90494546
Asocial behaviour 15.12 12.10 4 133585 19 90494839
Insulin resistance 15.10 12.10 13 133576 1145 90493713
Anhedonia 15.09 12.10 44 133545 11387 90483471
Binge eating 15.06 12.10 10 133579 595 90494263
Glucocorticoids increased 15.04 12.10 6 133583 120 90494738
Pain in jaw 15.01 12.10 30 133559 47955 90446903
Vaginal discharge 14.96 12.10 5 133584 19459 90475399
Gastrointestinal necrosis 14.95 12.10 21 133568 3204 90491654
Affective ambivalence 14.95 12.10 4 133585 20 90494838
Compulsive sexual behaviour 14.95 12.10 5 133584 59 90494799
Snoring 14.94 12.10 27 133562 5099 90489759
Poverty of speech 14.93 12.10 8 133581 320 90494538
Dermatitis atopic 14.89 12.10 8 133581 23464 90471394
Interstitial lung disease 14.85 12.10 60 133529 76345 90418513
Pseudomembranous colitis 14.78 12.10 23 133566 3845 90491013
Single umbilical artery 14.78 12.10 8 133581 327 90494531
No adverse event 14.77 12.10 51 133538 67931 90426927
Therapeutic product ineffective 14.74 12.10 18 133571 2396 90492462
Maternal exposure during breast feeding 14.73 12.10 30 133559 6190 90488668
Mood swings 14.67 12.10 65 133524 20637 90474221
Brief psychotic disorder with marked stressors 14.65 12.10 5 133584 63 90494795
Blood pressure systolic increased 14.64 12.10 41 133548 58304 90436554
Thrombosis 14.57 12.10 57 133532 73194 90421664
Accelerated hypertension 14.53 12.10 9 133580 475 90494383
Pulmonary congestion 14.52 12.10 62 133527 19371 90475487
Overweight 14.51 12.10 29 133560 5905 90488953
Pelvic sepsis 14.49 12.10 3 133586 3 90494855
Onychogryphosis 14.49 12.10 3 133586 3 90494855
Dyskinesia neonatal 14.49 12.10 3 133586 3 90494855
Breath odour 14.44 12.10 14 133575 1437 90493421
Myocardial ischaemia 14.39 12.10 49 133540 13765 90481093
Subileus 14.39 12.10 22 133567 3622 90491236
Amaurosis 14.38 12.10 11 133578 819 90494039
Inappropriate affect 14.38 12.10 12 133577 1013 90493845
Dependent personality disorder 14.37 12.10 5 133584 67 90494791
Deja vu 14.34 12.10 6 133583 136 90494722
Excessive masturbation 14.34 12.10 4 133585 24 90494834
Carotid artery occlusion 14.33 12.10 30 133559 6312 90488546
Immunisation 14.33 12.10 17 133572 2196 90492662
Uveitis 14.28 12.10 3 133586 15900 90478958
Incoherent 14.24 12.10 26 133563 4951 90489907
Brain oedema 14.20 12.10 57 133532 17328 90477530
Neurotoxicity 14.17 12.10 66 133523 21401 90473457
Bone density decreased 14.15 12.10 4 133585 17341 90477517
Eating disorder 14.12 12.10 80 133509 27993 90466865
Cyclothymic disorder 14.09 12.10 7 133582 239 90494619
Bulimia nervosa 14.03 12.10 9 133580 505 90494353
Muscle tone disorder 13.99 12.10 6 133583 145 90494713
Swelling face 13.93 12.10 67 133522 81285 90413573
Ovarian germ cell cancer stage II 13.92 12.10 5 133584 74 90494784
Genitourinary symptom 13.91 12.10 6 133583 147 90494711
Acute hepatic failure 13.90 12.10 68 133521 22493 90472365
Dysgeusia 13.89 12.10 36 133553 52524 90442334
Panic attack 13.84 12.10 76 133513 26289 90468569
Clinodactyly 13.84 12.10 6 133583 149 90494709
Troponin increased 13.74 12.10 47 133542 13234 90481624
Parkinson's disease 13.74 12.10 12 133577 1078 90493780
Rapid eye movement sleep behaviour disorder 13.74 12.10 8 133581 377 90494481
Atonic urinary bladder 13.73 12.10 6 133583 152 90494706
Blood sodium increased 13.70 12.10 20 133569 3162 90491696
Negative thoughts 13.67 12.10 12 133577 1085 90493773
Electrocardiogram RR interval prolonged 13.63 12.10 3 133586 5 90494853
Decreased gait velocity 13.57 12.10 4 133585 30 90494828
Onychophagia 13.50 12.10 5 133584 81 90494777
Female sexual dysfunction 13.45 12.10 5 133584 82 90494776
Myelodysplastic syndrome 13.44 12.10 7 133582 20896 90473962
Poor personal hygiene 13.43 12.10 8 133581 393 90494465
Femur fracture 13.42 12.10 30 133559 46052 90448806
Picornavirus infection 13.39 12.10 5 133584 83 90494775
Emotional poverty 13.38 12.10 8 133581 396 90494462
Paralogism 13.34 12.10 4 133585 32 90494826
Gastrointestinal lymphoma 13.33 12.10 5 133584 84 90494774
Coagulation factor VII level decreased 13.28 12.10 5 133584 85 90494773
Sensory loss 13.28 12.10 5 133584 18070 90476788
Hyperinsulinism 13.28 12.10 3 133586 6 90494852
Thought insertion 13.28 12.10 3 133586 6 90494852
Intermittent explosive disorder 13.28 12.10 3 133586 6 90494852
Unwanted awareness during anaesthesia 13.27 12.10 8 133581 402 90494456
Blood glucose 13.24 12.10 4 133585 33 90494825
Tracheal injury 13.20 12.10 6 133583 167 90494691
Atrial tachycardia 13.15 12.10 28 133561 5962 90488896
Hyponatraemic syndrome 13.13 12.10 9 133580 565 90494293
Urine flow decreased 13.11 12.10 8 133581 411 90494447
Drug-disease interaction 13.07 12.10 11 133578 939 90493919
Cellulitis 13.00 12.10 80 133509 91257 90403601
Paradoxical pain 12.96 12.10 3 133586 7 90494851
Pseudobulbar palsy 12.96 12.10 3 133586 7 90494851
Pulmonary valve stenosis 12.95 12.10 8 133581 420 90494438
Malnutrition 12.95 12.10 58 133531 18500 90476358
Pseudomonas infection 12.95 12.10 3 133586 14862 90479996
Platelet count increased 12.94 12.10 63 133526 20796 90474062
Nephrogenic diabetes insipidus 12.87 12.10 11 133578 959 90493899
Autoimmune pericarditis 12.87 12.10 5 133584 93 90494765
Newborn persistent pulmonary hypertension 12.82 12.10 7 133582 291 90494567
Haematocrit increased 12.75 12.10 19 133570 3059 90491799
Glassy eyes 12.72 12.10 5 133584 96 90494762
Product storage error 12.69 12.10 7 133582 20234 90474624
Hypersomnia-bulimia syndrome 12.68 12.10 3 133586 8 90494850
Angina pectoris 12.67 12.10 24 133565 39136 90455722
Sleep deficit 12.62 12.10 11 133578 985 90493873
Temperature regulation disorder 12.58 12.10 3 133586 14576 90480282
Dysbiosis 12.58 12.10 14 133575 1688 90493170
Schizophreniform disorder 12.58 12.10 5 133584 99 90494759
Normochromic normocytic anaemia 12.55 12.10 25 133564 5077 90489781
Tachyphrenia 12.55 12.10 14 133575 1692 90493166
Neonatal behavioural syndrome 12.53 12.10 5 133584 100 90494758
Neonatal respiratory depression 12.49 12.10 6 133583 190 90494668
Epileptic psychosis 12.46 12.10 4 133585 41 90494817
Electrocardiogram QT shortened 12.46 12.10 6 133583 191 90494667
Neonatal oversedation 12.42 12.10 3 133586 9 90494849
Maternal exposure timing unspecified 12.41 12.10 9 133580 22474 90472384
Decubitus ulcer 12.40 12.10 42 133547 11771 90483087
Prolactin-producing pituitary tumour 12.40 12.10 5 133584 103 90494755
Protein urine present 12.38 12.10 30 133559 6954 90487904
Cytokine release syndrome 12.33 12.10 77 133512 27896 90466962
Dyschezia 12.32 12.10 18 133571 2847 90492011
Anal incontinence 12.30 12.10 52 133537 16178 90478680
Enterobacter bacteraemia 12.28 12.10 10 133579 816 90494042
Substance use disorder 12.23 12.10 15 133574 2005 90492853
Burning sensation 12.22 12.10 50 133539 63402 90431456
Thirst 12.19 12.10 52 133537 16243 90478615
Moaning 12.18 12.10 11 133578 1032 90493826
Visuospatial deficit 12.18 12.10 3 133586 10 90494848
Somatic hallucination 12.18 12.10 3 133586 10 90494848
Vital functions abnormal 12.14 12.10 9 133580 639 90494219
Diabetes insipidus 12.14 12.10 19 133570 3193 90491665

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 2649.62 12.40 1314 133808 20158 42466055
Sedation 1394.65 12.40 982 134140 29493 42456720
Post-injection delirium sedation syndrome 1364.32 12.40 329 134793 279 42485934
Extrapyramidal disorder 1147.09 12.40 690 134432 15722 42470491
Akathisia 1094.47 12.40 573 134549 9878 42476335
Psychotic disorder 991.54 12.40 787 134335 28421 42457792
Suicide attempt 926.47 12.40 923 134199 45177 42441036
Agitation 857.77 12.40 1038 134084 63276 42422937
Overdose 798.14 12.40 1295 133827 103969 42382244
Schizophrenia 793.06 12.40 465 134657 10085 42476128
Weight increased 779.03 12.40 1299 133823 106684 42379529
Hallucination, auditory 745.41 12.40 507 134615 14357 42471856
Parkinsonism 684.19 12.40 424 134698 10199 42476014
Aggression 684.09 12.40 770 134352 43393 42442820
Catatonia 664.36 12.40 346 134776 5893 42480320
Toxicity to various agents 616.19 12.40 1856 133266 227280 42258933
Intentional self-injury 601.86 12.40 449 134673 14753 42471460
Delusion 594.11 12.40 440 134682 14294 42471919
Treatment noncompliance 528.10 12.40 624 134498 37048 42449165
Intentional overdose 523.72 12.40 727 134395 50729 42435484
Dystonia 513.54 12.40 381 134741 12409 42473804
Sopor 511.63 12.40 385 134737 12817 42473396
Myocarditis 477.13 12.40 430 134692 18508 42467705
Salivary hypersecretion 459.68 12.40 335 134787 10608 42475605
Somnolence 443.52 12.40 1210 133912 139895 42346318
Blood creatine phosphokinase increased 431.83 12.40 642 134480 47696 42438517
Tachycardia 429.65 12.40 973 134149 100114 42386099
Muscle rigidity 428.50 12.40 334 134788 11725 42474488
Mania 427.49 12.40 316 134806 10231 42475982
Hyperprolactinaemia 392.26 12.40 172 134950 1951 42484262
Electrocardiogram QT prolonged 384.86 12.40 606 134516 47339 42438874
Arthralgia 364.51 12.40 100 135022 205138 42281075
Diarrhoea 363.19 12.40 564 134558 460285 42025928
Tardive dyskinesia 356.16 12.40 240 134882 6684 42479529
Prescribed overdose 350.44 12.40 306 134816 12621 42473592
Delirium 344.10 12.40 606 134516 51913 42434300
Mental impairment 332.76 12.40 291 134831 12026 42474187
Dysarthria 327.59 12.40 509 134613 39298 42446915
Psychotic symptom 323.52 12.40 156 134966 2234 42483979
Rash 321.79 12.40 245 134877 276709 42209504
Completed suicide 316.63 12.40 841 134281 95624 42390589
Coma 314.10 12.40 589 134533 52965 42433248
Depressed level of consciousness 303.28 12.40 545 134577 47425 42438788
Suicidal ideation 297.90 12.40 542 134580 47619 42438594
Oculogyric crisis 294.05 12.40 133 134989 1632 42484581
Increased appetite 285.02 12.40 232 134890 8674 42477539
Disinhibition 277.78 12.40 166 134956 3729 42482484
Dyspnoea 275.01 12.40 625 134497 441996 42044217
Obsessive-compulsive disorder 262.00 12.40 197 134925 6546 42479667
Restlessness 261.84 12.40 389 134733 28860 42457353
Serotonin syndrome 258.05 12.40 362 134760 25483 42460730
Paranoia 258.05 12.40 268 134854 13758 42472455
Abnormal behaviour 257.46 12.40 366 134756 26085 42460128
Blood prolactin abnormal 249.98 12.40 102 135020 953 42485260
Antipsychotic drug level below therapeutic 245.40 12.40 143 134979 3061 42483152
Priapism 244.10 12.40 185 134937 6222 42479991
Dyskinesia 243.71 12.40 349 134773 25041 42461172
Pruritus 240.26 12.40 151 134971 188620 42297593
Drug abuse 234.41 12.40 798 134324 103973 42382240
Pain 230.66 12.40 262 134860 244586 42241627
Diabetes mellitus 226.27 12.40 552 134570 59535 42426678
Metabolic syndrome 225.58 12.40 115 135007 1868 42484345
Fatigue 223.28 12.40 677 134445 434964 42051249
Emotional poverty 222.08 12.40 84 135038 628 42485585
Confusional state 217.82 12.40 1079 134043 166518 42319695
Euphoric mood 214.75 12.40 172 134950 6281 42479932
Blood prolactin increased 212.39 12.40 116 135006 2182 42484031
Sexual dysfunction 209.48 12.40 173 134949 6602 42479611
Blood triglycerides increased 209 12.40 255 134867 15641 42470572
Type 2 diabetes mellitus 207.54 12.40 274 134848 18197 42468016
Cough 198.48 12.40 164 134958 177939 42308274
Rhabdomyolysis 194.85 12.40 617 134505 77402 42408811
Death 193.51 12.40 804 134318 470381 42015832
Drug interaction 191.51 12.40 1474 133648 265525 42220688
Anosognosia 190.98 12.40 84 135038 960 42485253
Hypothermia 189.81 12.40 216 134906 12299 42473914
Metabolic disorder 188.50 12.40 141 134981 4647 42481566
Diabetic ketoacidosis 185.33 12.40 287 134835 22080 42464133
Anaemia 184.19 12.40 383 134739 279895 42206318
Tremor 182.51 12.40 698 134424 96231 42389982
Miosis 180.52 12.40 218 134904 13228 42472985
Disorientation 175.64 12.40 369 134753 36020 42450193
Therapeutic product effect variable 174.98 12.40 114 135008 2995 42483218
Pneumonia 172.17 12.40 722 134400 421427 42064786
Malignant neoplasm progression 170.71 12.40 65 135057 108335 42377878
Irritability 170.63 12.40 314 134808 27814 42458399
Psychomotor hyperactivity 169.37 12.40 191 134931 10767 42475446
Schizoaffective disorder 161.75 12.40 92 135030 1878 42484335
Thinking abnormal 159.78 12.40 152 134970 7009 42479204
Nausea 157.83 12.40 685 134437 396114 42090099
Antipsychotic drug level increased 154.48 12.40 124 134998 4542 42481671
Pain in extremity 150.73 12.40 153 134969 150451 42335762
Pneumonia aspiration 150.55 12.40 423 134699 49655 42436558
Obesity 150.29 12.40 221 134901 16238 42469975
Disturbance in social behaviour 142.14 12.40 82 135040 1721 42484492
Polydipsia 139.58 12.40 115 135007 4373 42481840
Disease progression 139.19 12.40 150 134972 143506 42342707
Speech disorder 139.01 12.40 294 134828 28827 42457386
Back pain 138.52 12.40 147 134975 141629 42344584
Anticholinergic syndrome 138.03 12.40 77 135045 1512 42484701
Leukopenia 136.34 12.40 533 134589 74213 42412000
Headache 136.31 12.40 353 134769 239016 42247197
Neutrophil count increased 134.12 12.40 232 134890 19572 42466641
Atrial fibrillation 129.50 12.40 151 134971 139442 42346771
Sinus tachycardia 128.34 12.40 233 134889 20420 42465793
Anxiety 127.60 12.40 725 134397 117835 42368378
Mental disorder 127.09 12.40 215 134907 17814 42468399
Joint swelling 126.60 12.40 30 135092 67992 42418221
Urticaria 124.08 12.40 40 135082 73996 42412217
Inspiratory capacity decreased 122.69 12.40 90 135032 2877 42483336
Delusional disorder, persecutory type 122.11 12.40 45 135077 310 42485903
Dyslipidaemia 122.04 12.40 150 134972 9268 42476945
Sedation complication 121.74 12.40 89 135033 2830 42483383
Erythema 120.08 12.40 101 135021 108692 42377521
Delusion of grandeur 119.26 12.40 76 135046 1920 42484293
Interstitial lung disease 118.67 12.40 50 135072 78412 42407801
Persecutory delusion 118.60 12.40 95 135027 3469 42482744
Acute kidney injury 118.51 12.40 682 134440 366655 42119558
Negativism 110.14 12.40 44 135078 387 42485826
Rheumatoid arthritis 109.95 12.40 6 135116 42434 42443779
Product dose omission issue 109.83 12.40 201 134921 154164 42332049
Cardiac failure congestive 109.42 12.40 68 135054 85534 42400679
Apathy 109.11 12.40 134 134988 8272 42477941
Infusion related reaction 107.06 12.40 30 135092 60776 42425437
Thrombosis 106.30 12.40 42 135080 68469 42417744
Asthma 105.60 12.40 33 135089 62281 42423932
Diabetic coma 105.07 12.40 55 135067 946 42485267
Drug hypersensitivity 101.65 12.40 99 135023 99290 42386923
Loss of consciousness 101.47 12.40 568 134554 91786 42394427
Poisoning deliberate 101.20 12.40 142 134980 9992 42476221
Psychiatric decompensation 98.75 12.40 92 135030 4130 42482083
Hyperammonaemia 98.26 12.40 123 134999 7743 42478470
Drug ineffective 97.74 12.40 2649 132473 627548 41858665
Antipsychotic drug level above therapeutic 97.52 12.40 57 135065 1227 42484986
Drooling 97.33 12.40 92 135030 4207 42482006
Bradykinesia 96.63 12.40 102 135020 5334 42480879
Granulocytopenia 96.56 12.40 116 135006 6998 42479215
Weight decreased 96.51 12.40 337 134785 207611 42278602
Cogwheel rigidity 96.39 12.40 64 135058 1737 42484476
Gastrointestinal haemorrhage 95.77 12.40 101 135021 97625 42388588
Respiratory depression 95.32 12.40 195 134927 18673 42467540
Dyspnoea exertional 93.54 12.40 22 135100 50126 42436087
Hallucination, visual 93.20 12.40 206 134916 20814 42465399
Social avoidant behaviour 91.89 12.40 80 135042 3284 42482929
Hallucination 91.33 12.40 393 134729 57114 42429099
Oedema peripheral 90.84 12.40 184 134938 135892 42350321
Prostate cancer 90.71 12.40 16 135106 44627 42441586
Hallucinations, mixed 90.44 12.40 80 135042 3355 42482858
Nasopharyngitis 90.22 12.40 80 135042 83916 42402297
Affective disorder 88.90 12.40 102 135020 5858 42480355
Peripheral swelling 86.56 12.40 95 135027 90175 42396038
Faecaloma 86.35 12.40 103 135019 6167 42480046
Infection 86.02 12.40 139 134983 111929 42374284
Hypomania 85.91 12.40 68 135054 2440 42483773
Altered state of consciousness 85.80 12.40 245 134877 29014 42457199
COVID-19 85.12 12.40 148 134974 115800 42370413
White blood cell count increased 85.02 12.40 325 134797 44762 42441451
Tension 84.81 12.40 67 135055 2397 42483816
Abdominal discomfort 84.09 12.40 69 135053 75186 42411027
Bradyphrenia 83.50 12.40 93 135029 5169 42481044
Withdrawal syndrome 83.44 12.40 160 134962 14615 42471598
Bipolar disorder 83.25 12.40 81 135041 3841 42482372
Agranulocytosis 82.75 12.40 249 134873 30363 42455850
Psoriasis 81.88 12.40 26 135096 48578 42437635
Psychiatric symptom 81.54 12.40 83 135039 4158 42482055
Decreased appetite 80.49 12.40 327 134795 192810 42293403
Generalised tonic-clonic seizure 80.40 12.40 224 134898 26155 42460058
Type 1 diabetes mellitus 80.32 12.40 93 135029 5394 42480819
Sepsis 80.27 12.40 342 134780 198992 42287221
Abdominal pain 79.68 12.40 322 134800 190149 42296064
Renal impairment 78.84 12.40 143 134979 110085 42376128
Hypertriglyceridaemia 78.42 12.40 126 134996 10000 42476213
Productive cough 77.74 12.40 33 135089 51534 42434679
Arthritis 77.38 12.40 19 135103 42046 42444167
Haematochezia 76.65 12.40 45 135077 58391 42427822
Unresponsive to stimuli 76.17 12.40 246 134876 31157 42455056
Heat stroke 75.84 12.40 46 135076 1062 42485151
Ascites 75.27 12.40 43 135079 56635 42429578
Intentional product use issue 74.07 12.40 71 135051 71762 42414451
Wheezing 73.55 12.40 41 135081 54740 42431473
Haemorrhage 73.47 12.40 51 135071 60512 42425701
Asthenia 73.39 12.40 555 134567 280238 42205975
Cerebrovascular accident 73.16 12.40 122 135000 97038 42389175
Stomatitis 73.05 12.40 34 135088 50295 42435918
Herpes zoster 72.62 12.40 17 135105 38860 42447353
Cognitive disorder 72.56 12.40 256 134866 33916 42452297
Renal failure 72.08 12.40 225 134897 143501 42342712
Injection site pain 71.01 12.40 48 135074 57750 42428463
Personality change 70.75 12.40 89 135033 5630 42480583
Influenza 70.72 12.40 56 135066 62119 42424094
Paradoxical drug reaction 70.52 12.40 81 135041 4657 42481556
Self-injurious ideation 69.09 12.40 53 135069 1815 42484398
Psychomotor retardation 68.52 12.40 77 135045 4322 42481891
Disturbance in attention 68.00 12.40 229 134893 29637 42456576
Accidental death 67.94 12.40 65 135057 3018 42483195
Spasmodic dysphonia 67.48 12.40 33 135089 488 42485725
Sinusitis 67.03 12.40 33 135089 47259 42438954
Pneumocystis jirovecii pneumonia 67.01 12.40 3 135119 25178 42461035
Skin exfoliation 66.91 12.40 24 135098 41529 42444684
Plasma cell myeloma 66.23 12.40 34 135088 47544 42438669
Hepatic steatosis 66.22 12.40 183 134939 21265 42464948
Arthropathy 66.16 12.40 8 135114 29589 42456624
Blood cholesterol increased 65.32 12.40 210 134912 26531 42459682
Obsessive thoughts 64.93 12.40 38 135084 820 42485393
Sudden death 64.92 12.40 155 134967 16474 42469739
International normalised ratio increased 64.74 12.40 36 135086 48132 42438081
Resting tremor 64.54 12.40 40 135082 961 42485252
Swelling 64.24 12.40 48 135074 54837 42431376
Poisoning 63.97 12.40 143 134979 14556 42471657
Obsessive-compulsive symptom 63.89 12.40 25 135097 207 42486006
Megacolon 63.75 12.40 55 135067 2230 42483983
Hyponatraemia 63.69 12.40 544 134578 100918 42385295
Mydriasis 63.68 12.40 106 135016 8664 42477549
Overweight 63.16 12.40 56 135066 2356 42483857
Myelosuppression 62.43 12.40 25 135097 40436 42445777
Pleurothotonus 62.33 12.40 42 135080 1169 42485044
Haematuria 62.11 12.40 55 135067 57744 42428469
Gout 61.70 12.40 8 135114 28047 42458166
Eosinophil count decreased 61.61 12.40 66 135056 3510 42482703
Psoriatic arthropathy 60.36 12.40 5 135117 24962 42461251
Septic shock 60.26 12.40 125 134997 91547 42394666
Neuropathy peripheral 59.56 12.40 148 134974 101705 42384508
Sexually inappropriate behaviour 59.10 12.40 32 135090 591 42485622
Blood creatinine increased 58.90 12.40 167 134955 109836 42376377
Hyperventilation 58.87 12.40 61 135061 3121 42483092
Chronic obstructive pulmonary disease 58.77 12.40 68 135054 63046 42423167
Cerebellar atrophy 58.49 12.40 34 135088 724 42485489
Melaena 58.07 12.40 25 135097 38721 42447492
Insomnia 57.73 12.40 601 134521 117652 42368561
Rhinalgia 56.82 12.40 47 135075 1797 42484416
Polydipsia psychogenic 56.70 12.40 21 135101 147 42486066
Illusion 56.12 12.40 37 135085 992 42485221
Eczema 56.07 12.40 19 135103 34067 42452146
Hyperreflexia 55.95 12.40 63 135059 3544 42482669
Torticollis 55.39 12.40 41 135081 1329 42484884
Inappropriate antidiuretic hormone secretion 54.95 12.40 145 134977 16396 42469817
Nephrolithiasis 54.82 12.40 24 135098 36806 42449407
Chronic kidney disease 54.41 12.40 42 135080 47199 42439014
Hallucination, olfactory 53.55 12.40 23 135099 247 42485966
Inappropriate affect 53.33 12.40 32 135090 724 42485489
Pulmonary fibrosis 53.26 12.40 10 135112 26671 42459542
General physical health deterioration 52.88 12.40 273 134849 150973 42335240
Rebound psychosis 52.84 12.40 21 135101 182 42486031
Hyperkalaemia 52.64 12.40 110 135012 80348 42405865
Refusal of treatment by patient 52.62 12.40 74 135048 5217 42480996
Water intoxication 52.60 12.40 26 135096 394 42485819
Frequent bowel movements 52.56 12.40 4 135118 21403 42464810
Hypersensitivity 52.52 12.40 93 135029 72277 42413936
Seizure 52.51 12.40 599 134523 119962 42366251
Chills 52.44 12.40 140 134982 93926 42392287
Stupor 52.23 12.40 57 135065 3096 42483117
Substance abuse 52.21 12.40 98 135024 8807 42477406
Multiple organ dysfunction syndrome 52.17 12.40 147 134975 96888 42389325
Pancreatitis necrotising 52.00 12.40 61 135061 3588 42482625
Pleural effusion 51.65 12.40 148 134974 97018 42389195
Antisocial behaviour 51.51 12.40 26 135096 413 42485800
Hyperglycaemic hyperosmolar nonketotic syndrome 51.45 12.40 42 135080 1576 42484637
Urinary retention 51.31 12.40 267 134855 41947 42444266
Angina pectoris 51.29 12.40 20 135102 32876 42453337
Blepharospasm 51.00 12.40 39 135083 1329 42484884
Blunted affect 50.98 12.40 25 135097 372 42485841
Intestinal pseudo-obstruction 50.56 12.40 48 135074 2207 42484006
Pancytopenia 50.49 12.40 197 134925 117546 42368667
Candida infection 50.44 12.40 5 135117 21605 42464608
Haemoglobin decreased 50.42 12.40 232 134890 132239 42353974
Muscular weakness 49.85 12.40 120 135002 83378 42402835
Cytomegalovirus infection 49.78 12.40 20 135102 32286 42453927
Troponin increased 49.59 12.40 153 134969 18909 42467304
Dry skin 49.57 12.40 48 135074 48290 42437923
Epistaxis 48.38 12.40 86 135036 66740 42419473
Fluid retention 48.03 12.40 20 135102 31599 42454614
Lymphocyte count abnormal 47.98 12.40 46 135076 2141 42484072
Leukaemia 47.71 12.40 74 135048 5698 42480515
Cardiac failure 47.61 12.40 176 134946 106680 42379533
Autonomic nervous system imbalance 47.61 12.40 54 135068 3062 42483151
Delusion of replacement 47.39 12.40 20 135102 205 42486008
Disorganised speech 47.38 12.40 38 135084 1390 42484823
Ileus paralytic 47.20 12.40 86 135036 7555 42478658
Paroxysmal perceptual alteration 46.96 12.40 20 135102 210 42486003
Pneumonitis 46.90 12.40 38 135084 41680 42444533
Grandiosity 46.70 12.40 22 135100 298 42485915
Drug use disorder 46.63 12.40 102 135020 10231 42475982
Feeling guilty 46.39 12.40 23 135099 351 42485862
Drug withdrawal syndrome 46.23 12.40 162 134960 21387 42464826
Intentional product misuse 45.97 12.40 345 134777 61555 42424658
COVID-19 pneumonia 45.57 12.40 7 135115 21606 42464607
Hypervolaemia 45.45 12.40 9 135113 23116 42463097
Haemoptysis 44.88 12.40 48 135074 46119 42440094
Mental status changes 44.87 12.40 257 134865 41858 42444355
Delusional disorder, unspecified type 44.84 12.40 29 135093 752 42485461
Asphyxia 44.37 12.40 88 135034 8238 42477975
Rebound effect 44.26 12.40 82 135040 7297 42478916
Hyperglycaemia 43.83 12.40 272 134850 45587 42440626
Bronchitis 43.78 12.40 51 135071 47150 42439063
Cardiomyopathy 43.46 12.40 147 134975 19063 42467150
Suspiciousness 43.41 12.40 23 135099 406 42485807
Anaphylactic reaction 43.18 12.40 43 135079 42700 42443513
Coronary artery disease 42.74 12.40 65 135057 53655 42432558
Neuralgia 42.70 12.40 14 135108 25633 42460580
Full blood count decreased 42.58 12.40 7 135115 20553 42465660
Derealisation 42.45 12.40 29 135093 826 42485387
Neutropenia 42.45 12.40 877 134245 198554 42287659
Diverticulitis 42.44 12.40 10 135112 22763 42463450
Bladder cancer 42.38 12.40 3 135119 17044 42469169
Aspiration 42.36 12.40 139 134983 17747 42468466
Antipsychotic drug level decreased 42.27 12.40 33 135089 1160 42485053
Neutrophil count decreased 41.89 12.40 344 134778 63071 42423142
Eye movement disorder 41.71 12.40 64 135058 4881 42481332
Aplastic anaemia 41.58 12.40 109 135013 12275 42473938
Rectal haemorrhage 41.45 12.40 58 135064 49548 42436665
Staphylococcal infection 41.43 12.40 35 135087 37608 42448605
Urinary tract infection 41.36 12.40 168 134954 99116 42387097
Coma scale abnormal 41.24 12.40 61 135061 4504 42481709
Hypertonia 41.17 12.40 64 135058 4937 42481276
Electrocardiogram abnormal 41.16 12.40 96 135026 10049 42476164
Reduced facial expression 40.95 12.40 36 135086 1497 42484716
Enuresis 40.93 12.40 47 135075 2701 42483512
Anxiolytic therapy 40.89 12.40 13 135109 53 42486160
Sleep disorder due to a general medical condition 40.83 12.40 4 135118 17449 42468764
Hyperammonaemic encephalopathy 40.80 12.40 47 135075 2711 42483502
Physical assault 40.68 12.40 31 135091 1051 42485162
Delusional perception 40.65 12.40 17 135105 170 42486043
Myocardial infarction 40.48 12.40 229 134893 123780 42362433
Myelodysplastic syndrome 40.44 12.40 11 135111 22734 42463479
Leukocytosis 40.41 12.40 194 134928 29514 42456699
Hanging 40.30 12.40 17 135105 174 42486039
Lung disorder 40.07 12.40 56 135066 47867 42438346
Urinary incontinence 39.86 12.40 155 134967 21513 42464700
Rash pruritic 39.82 12.40 29 135093 33574 42452639
Gynaecomastia 39.56 12.40 108 135014 12459 42473754
Multiple drug therapy 39.51 12.40 31 135091 1098 42485115
Bronchopulmonary aspergillosis 39.38 12.40 7 135115 19422 42466791
Drug therapy enhancement 39.26 12.40 13 135109 62 42486151
Musculoskeletal pain 39.21 12.40 29 135093 33311 42452902
Chest discomfort 39.11 12.40 90 135032 63526 42422687
Hyperhidrosis 39.07 12.40 449 134673 90063 42396150
Substance-induced psychotic disorder 39.03 12.40 47 135075 2842 42483371
Respiratory arrest 38.94 12.40 186 134936 28238 42457975
Panic attack 38.92 12.40 99 135023 10946 42475267
Upper respiratory tract infection 38.65 12.40 46 135076 42127 42444086
Dysgeusia 38.61 12.40 31 135091 34158 42452055
Wrong patient received product 38.47 12.40 52 135070 3531 42482682
Logorrhoea 38.47 12.40 46 135076 2761 42483452
Eosinophilic myocarditis 38.20 12.40 33 135089 1340 42484873
Therapeutic product effect incomplete 38.19 12.40 368 134754 70571 42415642
Pyrexia 38.07 12.40 955 134167 393087 42093126
White blood cell count decreased 37.99 12.40 525 134597 109871 42376342
Osteoarthritis 37.78 12.40 15 135107 24390 42461823
Visceral congestion 37.68 12.40 28 135094 913 42485300
Tubulointerstitial nephritis 37.68 12.40 27 135095 31521 42454692
Breast engorgement 37.66 12.40 9 135113 7 42486206
Bronchiectasis 37.61 12.40 6 135116 18013 42468200
Skin ulcer 37.60 12.40 17 135105 25584 42460629
Metastases to liver 37.53 12.40 4 135118 16322 42469891
Injection site erythema 37.38 12.40 9 135113 20186 42466027
Xanthoma 36.97 12.40 14 135108 105 42486108
Rhinorrhoea 36.95 12.40 28 135094 31766 42454447
Behaviour disorder 36.93 12.40 74 135048 6980 42479233
Muscle spasms 36.85 12.40 144 134978 85900 42400313
Acute myocardial infarction 36.80 12.40 81 135041 58084 42428129
Prostatic specific antigen increased 36.80 12.40 5 135117 16920 42469293
Dysphagia 36.61 12.40 372 134750 72347 42413866
Hyperthermia 36.57 12.40 105 135017 12469 42473744
Hyperphagia 36.40 12.40 35 135087 1635 42484578
Erectile dysfunction 36.31 12.40 166 134956 24747 42461466
Fungal infection 36.09 12.40 9 135113 19713 42466500
Painful erection 36.03 12.40 19 135103 332 42485881
Abulia 35.68 12.40 24 135098 666 42485547
Stress 35.65 12.40 53 135069 44159 42442054
Colitis 35.48 12.40 58 135064 46514 42439699
Impulsive behaviour 35.32 12.40 41 135081 2384 42483829
No adverse event 35.29 12.40 43 135079 38978 42447235
Inappropriate schedule of product administration 35.27 12.40 170 134952 95732 42390481
Soliloquy 35.24 12.40 23 135099 606 42485607
Motor dysfunction 35.17 12.40 79 135043 8067 42478146
Affect lability 35.05 12.40 53 135069 3991 42482222
Flat affect 35.03 12.40 28 135094 1019 42485194
Pulmonary mass 34.91 12.40 5 135117 16260 42469953
Appendicitis 34.76 12.40 11 135111 20602 42465611
Galactorrhoea 34.65 12.40 21 135101 484 42485729
Mutism 34.47 12.40 32 135090 1430 42484783
Inflammation 34.25 12.40 34 135088 33813 42452400
Contusion 34.18 12.40 50 135072 41935 42444278
Transient ischaemic attack 34.01 12.40 34 135088 33705 42452508
Psychosexual disorder 33.74 12.40 14 135108 137 42486076
Food craving 33.68 12.40 21 135101 510 42485703
Alcohol abuse 33.59 12.40 52 135070 3997 42482216
Retrograde ejaculation 33.54 12.40 21 135101 514 42485699
Blister 33.53 12.40 23 135099 27467 42458746
Abnormal weight gain 33.48 12.40 30 135092 1280 42484933
Protrusion tongue 33.31 12.40 16 135106 227 42485986
Hyperchylomicronaemia 33.30 12.40 7 135115 0 42486213
Cold-stimulus headache 33.30 12.40 7 135115 0 42486213
Dysphonia 33.13 12.40 25 135097 28425 42457788
Cardio-respiratory arrest 32.96 12.40 307 134815 58329 42427884
Brain injury 32.78 12.40 74 135048 7581 42478632
Depressive symptom 32.69 12.40 50 135072 3803 42482410
Product substitution issue 32.57 12.40 94 135028 11196 42475017
Obstructive airways disorder 32.55 12.40 19 135103 24740 42461473
Gaze palsy 32.54 12.40 35 135087 1870 42484343
Angioedema 32.27 12.40 53 135069 42424 42443789
Oscillopsia 32.11 12.40 16 135106 247 42485966
Urticaria cholinergic 32.05 12.40 9 135113 21 42486192
Blood pressure increased 31.78 12.40 191 134931 101737 42384476
Rash erythematous 31.60 12.40 33 135089 32058 42454155
Hyperbilirubinaemia 31.42 12.40 13 135109 20622 42465591
Diabetic hyperosmolar coma 31.36 12.40 20 135102 506 42485707
Negative symptoms in schizophrenia 31.35 12.40 12 135110 93 42486120
Encephalitis toxic 31.32 12.40 16 135106 261 42485952
Judgement impaired 31.24 12.40 21 135101 582 42485631
Selective eating disorder 31.17 12.40 33 135089 1731 42484482
Proteinuria 31.13 12.40 17 135105 22966 42463247
Colitis ischaemic 31.11 12.40 70 135052 7156 42479057
Hospitalisation 30.86 12.40 366 134756 73964 42412249
Posture abnormal 30.81 12.40 39 135083 2482 42483731
Pulmonary alveolar haemorrhage 30.78 12.40 5 135117 14811 42471402
Drug level increased 30.65 12.40 164 134958 26036 42460177
Waxy flexibility 30.60 12.40 12 135110 100 42486113
Staring 30.47 12.40 31 135091 1552 42484661
Eyelid function disorder 30.44 12.40 14 135108 179 42486034
Iatrogenic injury 30.39 12.40 24 135098 858 42485355
Hyperphosphataemia 30.37 12.40 3 135119 13001 42473212
Adrenal insufficiency 30.34 12.40 11 135111 18913 42467300
Myasthenia gravis 30.24 12.40 7 135115 16130 42470083
Bezoar 30.22 12.40 28 135094 1248 42484965
Oedema 30.04 12.40 76 135046 51925 42434288
Migraine 30.03 12.40 22 135100 25392 42460821
Pressure of speech 29.92 12.40 20 135102 549 42485664
Unevaluable event 29.74 12.40 39 135083 34249 42451964
Myoclonus 29.71 12.40 120 135002 16945 42469268
Palmar-plantar erythrodysaesthesia syndrome 29.71 12.40 14 135108 20568 42465645
Anaphylactic shock 29.59 12.40 19 135103 23498 42462715
Consciousness fluctuating 29.50 12.40 28 135094 1287 42484926
End stage renal disease 29.45 12.40 8 135114 16550 42469663
Oral discharge 29.44 12.40 13 135109 150 42486063
Apraxia 29.43 12.40 30 135092 1505 42484708
Bacterial infection 29.38 12.40 27 135095 27852 42458361
Body mass index increased 29.32 12.40 27 135095 1194 42485019
Incoherent 29.28 12.40 53 135069 4632 42481581
Colitis ulcerative 29.22 12.40 24 135098 26151 42460062
Manic symptom 29.00 12.40 14 135108 201 42486012
Patient elopement 28.99 12.40 13 135109 156 42486057
Abdominal pain upper 28.91 12.40 149 134973 82460 42403753
Bipolar I disorder 28.82 12.40 23 135099 835 42485378
Psychotic behaviour 28.74 12.40 24 135098 930 42485283
Injection site swelling 28.72 12.40 9 135113 16964 42469249
Hypersexuality 28.60 12.40 31 135091 1671 42484542
Intravascular papillary endothelial hyperplasia 28.54 12.40 6 135116 0 42486213
Personality disorder 28.47 12.40 26 135096 1137 42485076
Blood glucose increased 28.47 12.40 358 134764 73341 42412872
Jaw clicking 28.44 12.40 10 135112 59 42486154
Bone marrow failure 28.34 12.40 38 135084 33055 42453158
Cerebral haemorrhage 28.33 12.40 50 135072 38916 42447297
Nasal congestion 28.31 12.40 31 135091 29470 42456743
Peptostreptococcus infection 28.30 12.40 10 135112 60 42486153
Respiratory alkalosis 28.24 12.40 36 135086 2308 42483905
Trismus 28.18 12.40 40 135082 2844 42483369
Dementia with Lewy bodies 28.01 12.40 23 135099 870 42485343
Paradoxical embolism 27.99 12.40 7 135115 8 42486205
Upper gastrointestinal haemorrhage 27.81 12.40 33 135089 30266 42455947
Suicidal behaviour 27.46 12.40 29 135093 1517 42484696
Osteonecrosis of jaw 27.43 12.40 13 135109 19036 42467177
Withdrawal catatonia 27.26 12.40 14 135108 231 42485982
Impaired healing 27.20 12.40 10 135112 17043 42469170
Somnambulism 27.14 12.40 43 135079 3372 42482841
Paraesthesia 27.13 12.40 130 134992 73329 42412884
Hypogammaglobulinaemia 27.11 12.40 3 135119 11888 42474325
Depressed mood 27.10 12.40 146 134976 23238 42462975
Device issue 27.09 12.40 5 135117 13504 42472709
Alcohol use 27.09 12.40 39 135083 2809 42483404
Compartment syndrome 26.95 12.40 42 135080 3247 42482966
Troponin I increased 26.94 12.40 41 135081 3105 42483108
Osteomyelitis 26.92 12.40 12 135110 18211 42468002
Perseveration 26.84 12.40 11 135111 104 42486109
High density lipoprotein decreased 26.83 12.40 46 135076 3851 42482362
Long QT syndrome 26.73 12.40 41 135081 3126 42483087
Eosinophil count increased 26.71 12.40 85 135037 10678 42475535
Substance use disorder 26.71 12.40 55 135067 5290 42480923
Somatic symptom disorder 26.52 12.40 21 135101 754 42485459
Cerebrovascular stenosis 26.39 12.40 11 135111 109 42486104
Dysphoria 26.35 12.40 38 135084 2742 42483471
Dehydration 26.27 12.40 305 134817 141462 42344751
Clostridium difficile infection 26.27 12.40 20 135102 22639 42463574
Malignant catatonia 26.24 12.40 17 135105 442 42485771
Symptom masked 26.20 12.40 22 135100 859 42485354
Hypomagnesaemia 26.18 12.40 31 135091 28457 42457756
Renal disorder 26.14 12.40 32 135090 28948 42457265
Injection site bruising 26.04 12.40 3 135119 11522 42474691
Blood bilirubin increased 25.78 12.40 60 135062 42192 42444021
Squamous cell carcinoma 25.62 12.40 5 135117 12977 42473236
Agitated depression 25.60 12.40 14 135108 264 42485949
Orthostatic hypertension 25.49 12.40 17 135105 465 42485748
Orthostatic hypotension 25.35 12.40 175 134947 30395 42455818
Cataract 25.35 12.40 36 135086 30568 42455645
Breath sounds abnormal 25.30 12.40 4 135118 12089 42474124
Akinesia 25.22 12.40 35 135087 2437 42483776
Hypometabolism 25.19 12.40 12 135110 167 42486046
Ear infection 25.13 12.40 5 135117 12799 42473414
Bone pain 25.12 12.40 23 135099 23769 42462444
Shock haemorrhagic 25.11 12.40 10 135112 16232 42469981
Blood pressure systolic increased 25.10 12.40 31 135091 27937 42458276
Illness anxiety disorder 24.75 12.40 12 135110 174 42486039
Hunger 24.69 12.40 31 135091 1957 42484256
Camptocormia 24.63 12.40 12 135110 176 42486037
Myalgia 24.50 12.40 191 134931 95889 42390324
Hypoaesthesia 24.38 12.40 130 134992 71333 42414880
Acute psychosis 24.32 12.40 32 135090 2117 42484096
Abdominal distension 24.20 12.40 131 134991 71604 42414609
Thrombocytopenia 24.19 12.40 441 134681 189838 42296375
Gastrointestinal sounds abnormal 24.18 12.40 33 135089 2261 42483952
Illness 24.14 12.40 26 135096 24904 42461309
Neoplasm malignant 24.00 12.40 22 135100 22721 42463492
Night sweats 23.96 12.40 17 135105 19952 42466261
Haemophagocytic lymphohistiocytosis 23.93 12.40 14 135108 18208 42468005
Faeces discoloured 23.91 12.40 12 135110 17002 42469211
C-reactive protein increased 23.80 12.40 307 134815 63253 42422960
Hepatitis C virus test positive 23.76 12.40 14 135108 306 42485907
Ballismus 23.48 12.40 10 135112 105 42486108
Pulmonary hypertension 23.47 12.40 24 135098 23545 42462668
Arteriosclerosis 23.37 12.40 14 135108 17975 42468238
Osteoporosis 23.34 12.40 9 135113 14897 42471316
Parkinsonian rest tremor 23.32 12.40 14 135108 317 42485896
Feeling hot 23.29 12.40 24 135098 23458 42462755
Acute myeloid leukaemia 22.93 12.40 22 135100 22234 42463979
Compulsive sexual behaviour 22.83 12.40 13 135109 266 42485947
Product use issue 22.78 12.40 146 134976 76605 42409608
Activation syndrome 22.72 12.40 11 135111 159 42486054
Patient restraint 22.64 12.40 9 135113 78 42486135
Hyperarousal 22.64 12.40 8 135114 48 42486165
Osteonecrosis 22.58 12.40 11 135111 15854 42470359
Ulcer 22.50 12.40 12 135110 16429 42469784
Surgery 22.48 12.40 14 135108 17602 42468611
Flatulence 22.45 12.40 28 135094 25124 42461089
Drug withdrawal syndrome neonatal 22.40 12.40 46 135076 4415 42481798
Nodule 22.40 12.40 6 135116 12528 42473685
Snoring 22.40 12.40 43 135079 3930 42482283
Localised infection 22.35 12.40 19 135103 20354 42465859
Pneumothorax 22.30 12.40 25 135097 23518 42462695
Therapy non-responder 22.26 12.40 263 134859 53096 42433117
Pulmonary arterial hypertension 22.17 12.40 3 135119 10184 42476029
Blood ethanol 22.16 12.40 9 135113 83 42486130
Depression 22.12 12.40 485 134637 110878 42375335
Tachyphrenia 22.09 12.40 25 135097 1414 42484799
Lipids increased 22 12.40 23 135099 1189 42485024
Homicidal ideation 21.95 12.40 35 135087 2759 42483454
Hyperthyroidism 21.89 12.40 9 135113 14332 42471881
Choreoathetosis 21.86 12.40 22 135100 1087 42485126
Oromandibular dystonia 21.74 12.40 17 135105 599 42485614
Hostility 21.53 12.40 19 135103 794 42485419
Metastases to bone 21.49 12.40 10 135112 14799 42471414
Flushing 21.47 12.40 54 135068 36974 42449239
Pemphigoid 21.44 12.40 5 135117 11462 42474751
Skin cancer 21.42 12.40 5 135117 11457 42474756
Chromaturia 21.41 12.40 12 135110 15977 42470236
Self-destructive behaviour 21.38 12.40 14 135108 371 42485842
Exhibitionism 21.36 12.40 8 135114 58 42486155
Drug level below therapeutic 21.35 12.40 57 135065 6488 42479725
Full blood count abnormal 21.12 12.40 39 135083 29837 42456376
Ejaculation disorder 21.04 12.40 21 135101 1027 42485186
Ataxia 20.99 12.40 104 135018 16021 42470192
Total cholesterol/HDL ratio increased 20.92 12.40 11 135111 191 42486022
Blood loss anaemia 20.88 12.40 3 135119 9733 42476480
Gastrointestinal hypomotility 20.77 12.40 23 135099 1270 42484943
Tongue movement disturbance 20.75 12.40 10 135112 143 42486070
Major depression 20.73 12.40 50 135072 5348 42480865
Pain in jaw 20.73 12.40 10 135112 14492 42471721
Troponin T increased 20.72 12.40 34 135088 2746 42483467
Dermatitis 20.63 12.40 6 135116 11869 42474344
Basal cell carcinoma 20.61 12.40 25 135097 22708 42463505
Pancreatitis haemorrhagic 20.58 12.40 14 135108 396 42485817
Skin lesion 20.55 12.40 34 135088 27140 42459073
Eosinophilic pleural effusion 20.48 12.40 13 135109 326 42485887
Dissociative disorder 20.44 12.40 17 135105 655 42485558
Vasculitis 20.37 12.40 17 135105 18377 42467836
Haematoma 20.33 12.40 36 135086 27987 42458226
Traumatic coma 20.28 12.40 6 135116 18 42486195
Cardiac disorder 20.24 12.40 83 135039 48849 42437364
Confabulation 20.20 12.40 10 135112 152 42486061
Electroencephalogram abnormal 20.18 12.40 35 135087 2957 42483256
Asocial behaviour 20.16 12.40 8 135114 69 42486144
Obsessive-compulsive personality disorder 20.09 12.40 10 135112 154 42486059
Skin discolouration 19.99 12.40 22 135100 20868 42465345
Mixed delusion 19.95 12.40 7 135115 41 42486172
Somatic hallucination 19.95 12.40 7 135115 41 42486172
Ketoacidosis 19.94 12.40 49 135073 5303 42480910
Injection site pruritus 19.93 12.40 3 135119 9402 42476811
Respiratory failure 19.91 12.40 286 134836 127846 42358367
Heart rate decreased 19.87 12.40 55 135067 36477 42449736
Impaired self-care 19.86 12.40 22 135100 1215 42484998
Loss of personal independence in daily activities 19.68 12.40 86 135036 49730 42436483
Clostridium difficile colitis 19.66 12.40 23 135099 21229 42464984
Encephalitis autoimmune 19.59 12.40 23 135099 1354 42484859
Restless legs syndrome 19.53 12.40 71 135051 9543 42476670
C-reactive protein abnormal 19.52 12.40 3 135119 9258 42476955
Eye pruritus 19.40 12.40 6 135116 11406 42474807
Alcoholic seizure 19.37 12.40 6 135116 22 42486191
Left ventricular dysfunction 19.33 12.40 80 135042 11421 42474792
Rash maculo-papular 19.28 12.40 58 135064 37445 42448768
Drug eruption 19.25 12.40 27 135095 23048 42463165
Blood urea decreased 19.20 12.40 23 135099 1383 42484830
Tangentiality 19.17 12.40 9 135113 121 42486092
Wrong patient 19.09 12.40 16 135106 623 42485590
Laboratory test abnormal 19.06 12.40 27 135095 22951 42463262
Illiteracy 19.03 12.40 5 135117 8 42486205
Chylomicron increased 19.03 12.40 4 135118 0 42486213
Blood thrombin increased 19.03 12.40 4 135118 0 42486213
Histrionic personality disorder 19.03 12.40 4 135118 0 42486213
Lymphocyte count decreased 18.97 12.40 152 134970 27657 42458556
Cataract cortical 18.97 12.40 9 135113 124 42486089
Pulmonary embolism 18.94 12.40 505 134617 119107 42367106
Tic 18.93 12.40 30 135092 2353 42483860
Agitation neonatal 18.91 12.40 23 135099 1405 42484808
Blood phosphorus increased 18.90 12.40 8 135114 12517 42473696
Dissociation 18.88 12.40 39 135083 3759 42482454
Conversion disorder 18.79 12.40 15 135107 545 42485668
Cytomegalovirus infection reactivation 18.79 12.40 6 135116 11172 42475041
Cyclothymic disorder 18.78 12.40 9 135113 127 42486086
Blood creatine phosphokinase MB increased 18.78 12.40 27 135095 1943 42484270
Multiple sclerosis relapse 18.68 12.40 11 135111 14253 42471960
Abscess 18.64 12.40 11 135111 14237 42471976
Mobility decreased 18.58 12.40 54 135068 35252 42450961
Skin fissures 18.53 12.40 4 135118 9672 42476541
Metastases to central nervous system 18.42 12.40 5 135117 10350 42475863
Cystitis 18.42 12.40 7 135115 11691 42474522
Lymphadenopathy 18.32 12.40 50 135072 33315 42452898
Bacteraemia 18.32 12.40 32 135090 25008 42461205
Somatic delusion 18.30 12.40 8 135114 90 42486123
Haematotoxicity 18.28 12.40 6 135116 10979 42475234
Hemiparaesthesia 18.26 12.40 10 135112 189 42486024
Rash macular 18.23 12.40 16 135106 16875 42469338
Paraphilia 18.14 12.40 8 135114 92 42486121
Electrocardiogram PR prolongation 18.07 12.40 19 135103 989 42485224
Pancreatic carcinoma 18.06 12.40 4 135118 9502 42476711
Aortic stenosis 18.06 12.40 3 135119 8742 42477471
Embolism venous 17.99 12.40 26 135096 1880 42484333
Hypophosphataemia 17.98 12.40 24 135098 20921 42465292
Drug level above therapeutic 17.84 12.40 50 135072 5856 42480357
Hot flush 17.82 12.40 27 135095 22324 42463889
Pulmonary toxicity 17.80 12.40 3 135119 8652 42477561
Lethargy 17.77 12.40 227 134895 46663 42439550
Postural tremor 17.77 12.40 14 135108 499 42485714
Poor quality sleep 17.74 12.40 68 135054 9372 42476841
Anger 17.69 12.40 85 135037 12933 42473280
Chemical poisoning 17.55 12.40 8 135114 100 42486113
Hepatic failure 17.45 12.40 62 135060 38038 42448175
Bundle branch block right 17.43 12.40 61 135061 8045 42478168
Large intestine polyp 17.40 12.40 4 135118 9261 42476952
Gastrointestinal hypermotility 17.39 12.40 9 135113 151 42486062
Dextrocardia 17.38 12.40 7 135115 63 42486150
Salivary gland calculus 17.34 12.40 8 135114 103 42486110
Dizziness 17.33 12.40 631 134491 248623 42237590
Clonus 17.33 12.40 36 135086 3484 42482729
Red cell distribution width decreased 17.33 12.40 11 135111 276 42485937
Hepatic cancer 17.31 12.40 3 135119 8477 42477736
Electrocardiogram QRS complex prolonged 17.30 12.40 49 135073 5774 42480439
Epilepsy 17.29 12.40 142 134980 26029 42460184
Drug monitoring procedure incorrectly performed 17.26 12.40 12 135110 352 42485861
Neck pain 17.23 12.40 44 135078 29970 42456243
Wrong technique in product usage process 17.21 12.40 73 135049 42562 42443651
Thrombotic microangiopathy 17.20 12.40 13 135109 14769 42471444
Stereotypy 17.14 12.40 17 135105 825 42485388
Electrocardiogram QT shortened 17.13 12.40 9 135113 156 42486057
Polyuria 17.11 12.40 70 135052 9941 42476272
Gastric haemorrhage 17.05 12.40 6 135116 10509 42475704
Hypernatraemia 17.03 12.40 70 135052 9962 42476251
Hepatitis cholestatic 17.00 12.40 5 135117 9819 42476394
Graft versus host disease 16.88 12.40 10 135112 12915 42473298
Hypokinesia 16.86 12.40 69 135053 9802 42476411
Pneumonia bacterial 16.77 12.40 15 135107 15677 42470536
Hypotonia 16.70 12.40 67 135055 9432 42476781
Gastric ulcer 16.64 12.40 20 135102 18242 42467971
Hypotonia neonatal 16.64 12.40 22 135100 1462 42484751
Echolalia 16.54 12.40 12 135110 377 42485836
Gambling disorder 16.43 12.40 24 135098 1752 42484461
Oropharyngeal pain 16.42 12.40 74 135048 42436 42443777
Wound 16.41 12.40 18 135104 17099 42469114
Depersonalisation/derealisation disorder 16.41 12.40 15 135107 657 42485556
Dry eye 16.36 12.40 15 135107 15491 42470722
Myotonia 16.32 12.40 6 135116 41 42486172
Slow speech 16.28 12.40 24 135098 1766 42484447
Gastric infection 16.27 12.40 22 135100 1494 42484719
Neoplasm progression 16.27 12.40 43 135079 28957 42457256
Visual acuity reduced 16.23 12.40 19 135103 17531 42468682
Cerebellar syndrome 16.22 12.40 31 135091 2824 42483389
Angina unstable 16.20 12.40 8 135114 11440 42474773
Blood ketone body 16.20 12.40 8 135114 121 42486092
Limb injury 16.11 12.40 13 135109 14292 42471921
Pseudomonas infection 16.10 12.40 16 135106 15907 42470306
Coordination abnormal 15.97 12.40 59 135063 7991 42478222
Blood sodium increased 15.94 12.40 33 135089 3185 42483028
Drowning 15.90 12.40 13 135109 489 42485724
Vascular stenosis 15.90 12.40 9 135113 182 42486031
Choking 15.87 12.40 50 135072 6248 42479965
Pulmonary valve incompetence 15.84 12.40 19 135103 1144 42485069
Gastrointestinal disorder 15.84 12.40 85 135037 46568 42439645
Impaired quality of life 15.82 12.40 13 135109 14164 42472049
Porphyria acute 15.82 12.40 12 135110 404 42485809
Throat irritation 15.77 12.40 11 135111 13025 42473188
Intention tremor 15.72 12.40 13 135109 497 42485716
Premature baby 15.69 12.40 31 135091 23122 42463091
Blood creatine phosphokinase decreased 15.69 12.40 14 135108 594 42485619
Device related infection 15.68 12.40 25 135097 20254 42465959
Injection site reaction 15.67 12.40 16 135106 15705 42470508
Post procedural haemorrhage 15.65 12.40 5 135117 9307 42476906
Autoscopy 15.64 12.40 10 135112 254 42485959
Dermatitis atopic 15.64 12.40 10 135112 12394 42473819
Drug screen positive 15.58 12.40 38 135084 4093 42482120
Chorea 15.57 12.40 21 135101 1423 42484790
Foetal alcohol syndrome 15.54 12.40 7 135115 85 42486128
Blood chloride decreased 15.53 12.40 38 135084 4101 42482112
Toxic epidermal necrolysis 15.52 12.40 39 135083 26711 42459502
Uveitis 15.50 12.40 5 135117 9253 42476960
Lacrimation increased 15.49 12.40 9 135113 11749 42474464
Blood osmolarity increased 15.46 12.40 12 135110 418 42485795
Product storage error 15.44 12.40 8 135114 11132 42475081
Legal problem 15.42 12.40 8 135114 135 42486078
Alanine aminotransferase increased 15.38 12.40 378 134744 88028 42398185
Labelled drug-drug interaction medication error 15.37 12.40 16 135106 15566 42470647
Viral infection 15.32 12.40 30 135092 22453 42463760
Blood pressure decreased 15.32 12.40 115 135007 58217 42427996
Gamma-glutamyltransferase increased 15.28 12.40 164 134958 32333 42453880
Posterior reversible encephalopathy syndrome 15.27 12.40 11 135111 12810 42473403
Glassy eyes 15.26 12.40 8 135114 138 42486075
Encephalocele 15.25 12.40 5 135117 23 42486190
Burning sensation 15.24 12.40 27 135095 20986 42465227
Lip swelling 15.20 12.40 23 135099 19030 42467183
Fear 15.19 12.40 72 135050 10893 42475320
Immunosuppression 15.19 12.40 4 135118 8449 42477764
Mouth ulceration 15.17 12.40 15 135107 14948 42471265
Parosmia 15.10 12.40 3 135119 7688 42478525
Posturing 15.01 12.40 13 135109 530 42485683
Libido disorder 14.98 12.40 11 135111 352 42485861
Peripheral coldness 14.98 12.40 4 135118 8371 42477842
Lymphocyte count increased 14.92 12.40 37 135085 4027 42482186
Fluid intake restriction 14.91 12.40 5 135117 25 42486188
Myopathy 14.89 12.40 13 135109 13748 42472465
Emotional disorder 14.89 12.40 49 135073 6265 42479948
Tumour lysis syndrome 14.86 12.40 30 135092 22201 42464012
Congenital megaureter 14.86 12.40 8 135114 146 42486067
Delusion of reference 14.85 12.40 7 135115 95 42486118
Hemiparesis 14.83 12.40 20 135102 17356 42468857
Hyperinsulinism 14.80 12.40 6 135116 55 42486158
Hypersomnia 14.78 12.40 88 135034 14530 42471683
Gastrooesophageal reflux disease 14.75 12.40 83 135039 44940 42441273
Angle closure glaucoma 14.74 12.40 18 135104 1104 42485109
Deafness 14.73 12.40 12 135110 13128 42473085
Tobacco interaction 14.72 12.40 7 135115 97 42486116
Throat tightness 14.69 12.40 6 135116 9593 42476620
Fever neonatal 14.67 12.40 8 135114 150 42486063
Staphylococcal sepsis 14.67 12.40 9 135113 11405 42474808
Secondary tic 14.66 12.40 4 135118 8 42486205
Organising pneumonia 14.66 12.40 3 135119 7529 42478684
Lower respiratory tract infection 14.59 12.40 74 135048 41132 42445081
Right ventricular failure 14.58 12.40 6 135116 9549 42476664
Joint injury 14.55 12.40 15 135107 14661 42471552
Cor pulmonale acute 14.51 12.40 10 135112 289 42485924
Benign prostatic hyperplasia 14.43 12.40 28 135094 21024 42465189
Acute pulmonary oedema 14.40 12.40 60 135062 8591 42477622
Vertigo 14.37 12.40 58 135064 34289 42451924
Acute graft versus host disease in skin 14.36 12.40 3 135119 7421 42478792
Strabismus congenital 14.29 12.40 5 135117 29 42486184
Lipomeningocele 14.27 12.40 3 135119 0 42486213
Schizoid personality disorder 14.27 12.40 3 135119 0 42486213
Haemorrhoids 14.27 12.40 20 135102 17077 42469136
Gastrointestinal obstruction 14.27 12.40 18 135104 1142 42485071
Drug dependence 14.23 12.40 148 134974 28946 42457267
Small intestinal obstruction 14.20 12.40 20 135102 17041 42469172
Malignant melanoma 14.19 12.40 6 135116 9394 42476819
Homosexuality 14.17 12.40 6 135116 62 42486151
Tricuspid valve sclerosis 14.15 12.40 5 135117 30 42486183
Aspartate aminotransferase increased 14.05 12.40 332 134790 76831 42409382
Olfactory nerve disorder 14.01 12.40 6 135116 64 42486149
Respiration abnormal 14.00 12.40 36 135086 4006 42482207
Tremor neonatal 13.92 12.40 12 135110 486 42485727
Hyperosmolar state 13.88 12.40 12 135110 488 42485725
Hernia 13.86 12.40 9 135113 11064 42475149
Substance use 13.85 12.40 22 135100 1729 42484484
Renal tubular necrosis 13.84 12.40 23 135099 18331 42467882
Foreign body aspiration 13.84 12.40 10 135112 312 42485901
Ventricular fibrillation 13.81 12.40 49 135073 30074 42456139
Sluggishness 13.81 12.40 35 135087 3861 42482352
Hepatitis viral 13.76 12.40 15 135107 814 42485399
Apnoea 13.69 12.40 55 135067 7748 42478465
Nocturia 13.65 12.40 11 135111 12101 42474112
Gastrectomy 13.61 12.40 8 135114 174 42486039
SARS-CoV-2 test positive 13.53 12.40 57 135065 8203 42478010
Sinus bradycardia 13.50 12.40 87 135035 14766 42471447
Therapeutic product effect decreased 13.47 12.40 71 135051 39079 42447134
Pancreatitis acute 13.37 12.40 164 134958 33400 42452813
Brain oedema 13.26 12.40 93 135029 16234 42469979
Selective mutism 13.24 12.40 6 135116 74 42486139
Gastric disorder 13.22 12.40 11 135111 11911 42474302
Cardiogenic shock 13.20 12.40 63 135059 35577 42450636
Arrhythmia 13.15 12.40 190 134932 40127 42446086
Product dose omission in error 13.15 12.40 5 135117 8349 42477864
Flight of ideas 13.15 12.40 10 135112 338 42485875
Basophil count decreased 13.14 12.40 7 135115 125 42486088
Sinus congestion 13.14 12.40 3 135119 6977 42479236
Purpura 13.13 12.40 11 135111 11868 42474345
Extrasystoles 13.08 12.40 36 135086 4173 42482040
Cholangitis 13.05 12.40 9 135113 10718 42475495
Bladder dilatation 13.04 12.40 21 135101 1669 42484544
Electrocardiogram ST segment elevation 13.04 12.40 45 135077 5894 42480319
Drug intolerance 13.03 12.40 178 134944 80246 42405967
Sputum discoloured 13.00 12.40 8 135114 10124 42476089
Circadian rhythm sleep disorder 12.97 12.40 12 135110 534 42485679
Pseudohallucination 12.93 12.40 5 135117 40 42486173
Blood insulin abnormal 12.84 12.40 4 135118 15 42486198
Duodenal ulcer 12.81 12.40 12 135110 12267 42473946
Foetal arrhythmia 12.80 12.40 7 135115 132 42486081
Globulins decreased 12.80 12.40 10 135112 352 42485861
Frontotemporal dementia 12.76 12.40 9 135113 270 42485943
Thirst 12.76 12.40 60 135062 9048 42477165
Febrile neutropenia 12.72 12.40 715 134407 184988 42301225
Amphetamines positive 12.70 12.40 8 135114 198 42486015
Head banging 12.66 12.40 8 135114 199 42486014
Tinnitus 12.66 12.40 48 135074 28890 42457323
Skin infection 12.61 12.40 7 135115 9373 42476840
Family stress 12.61 12.40 7 135115 136 42486077
Spinal compression fracture 12.60 12.40 4 135118 7479 42478734
Foetal heart rate abnormal 12.59 12.40 8 135114 201 42486012
Low birth weight baby 12.58 12.40 8 135114 9947 42476266
Glucose tolerance impaired 12.54 12.40 35 135087 4089 42482124
Cardiac dysfunction 12.53 12.40 31 135091 3368 42482845
Ageusia 12.51 12.40 11 135111 11594 42474619
Subdural haematoma 12.46 12.40 35 135087 23103 42463110
Pain of skin 12.45 12.40 5 135117 8075 42478138
Abdominal pain lower 12.40 12.40 12 135110 12080 42474133

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 4452.24 11.94 1907 227915 32152 110327325
Sedation 2349.89 11.94 1582 228240 68101 110291376
Suicide attempt 2316.95 11.94 1833 227989 101561 110257916
Extrapyramidal disorder 2300.05 11.94 1147 228675 27720 110331757
Akathisia 1939.02 11.94 867 228955 16246 110343231
Post-injection delirium sedation syndrome 1739.40 11.94 387 229435 382 110359095
Agitation 1720.06 11.94 1606 228216 111445 110248032
Psychotic disorder 1583.10 11.94 1100 228722 49837 110309640
Intentional overdose 1574.76 11.94 1645 228177 130856 110228621
Toxicity to various agents 1567.45 11.94 3227 226595 477328 109882149
Dystonia 1473.99 11.94 821 229001 24984 110334493
Schizophrenia 1394.94 11.94 748 229074 21078 110338399
Sopor 1392.64 11.94 896 228926 35650 110323827
Parkinsonism 1330.66 11.94 729 229093 21458 110338019
Intentional self-injury 1280.89 11.94 858 228964 36571 110322906
Catatonia 1252.95 11.94 564 229258 10736 110348741
Overdose 1235.06 11.94 1939 227883 231855 110127622
Hallucination, auditory 1228.29 11.94 735 229087 25662 110333815
Somnolence 1222.88 11.94 2205 227617 295244 110064233
Delusion 1124.96 11.94 669 229153 23086 110336391
Aggression 1097.85 11.94 941 228881 58269 110301208
Blood prolactin abnormal 1039.10 11.94 365 229457 3470 110356007
Drug abuse 1036.12 11.94 1542 228280 175869 110183608
Sexual dysfunction 1013.82 11.94 447 229375 8083 110351394
Completed suicide 983.18 11.94 1787 228035 240594 110118883
Electrocardiogram QT prolonged 983.16 11.94 1172 228650 107788 110251689
Hyperprolactinaemia 947.81 11.94 395 229427 6180 110353297
Dyskinesia 891.94 11.94 787 229035 50659 110308818
Salivary hypersecretion 873.13 11.94 509 229313 16912 110342565
Arthralgia 866.79 11.94 272 229550 779360 109580117
Anosognosia 865.55 11.94 324 229498 3750 110355727
Suicidal ideation 846.70 11.94 1010 228812 92927 110266550
Muscle rigidity 827.20 11.94 553 229269 23478 110335999
Treatment noncompliance 823.51 11.94 882 228940 72108 110287369
Coma 797.25 11.94 1099 228723 116770 110242707
Drug interaction 786.43 11.94 2554 227268 497629 109861848
Tardive dyskinesia 780.72 11.94 434 229388 13145 110346332
Pain 775.49 11.94 518 229304 954437 109405040
Metabolic disorder 741.86 11.94 385 229437 10125 110349352
Mania 738.60 11.94 488 229334 20308 110339169
Disturbance in social behaviour 736.27 11.94 306 229516 4752 110354725
Tachycardia 714.34 11.94 1503 228319 225142 110134335
Depressed level of consciousness 694.29 11.94 1003 228819 111275 110248202
Myocarditis 679.15 11.94 536 229286 29519 110329958
Blood creatine phosphokinase increased 639.23 11.94 774 229048 72303 110287174
Oculogyric crisis 602.55 11.94 245 229577 3587 110355890
Joint swelling 602.05 11.94 99 229723 442746 109916731
Infusion related reaction 560.77 11.94 67 229755 381095 109978382
Personality change 550.10 11.94 321 229501 10681 110348796
Metabolic syndrome 532.59 11.94 214 229608 3033 110356444
Rheumatoid arthritis 524.56 11.94 23 229799 299590 110059887
Rash 510.72 11.94 573 229249 820391 109539086
Weight increased 509.26 11.94 1969 227853 417675 109941802
Abnormal behaviour 509.10 11.94 510 229312 38529 110320948
Arthropathy 506.93 11.94 21 229801 287501 110071976
Restlessness 497.08 11.94 599 229223 55660 110303817
Serotonin syndrome 497.00 11.94 614 229208 58539 110300938
Hypothermia 491.38 11.94 420 229402 25882 110333595
Delirium 481.59 11.94 943 228879 134082 110225395
Hypomania 479.30 11.94 286 229536 9924 110349553
Psychotic symptom 476.87 11.94 208 229614 3659 110355818
Tremor 467.00 11.94 1187 228635 201045 110158432
Rhabdomyolysis 463.98 11.94 869 228953 119532 110239945
Pruritus 462.40 11.94 322 229500 581238 109778239
Dysarthria 461.93 11.94 711 229111 83410 110276067
Paranoia 456.65 11.94 376 229446 21998 110337479
Miosis 454.05 11.94 372 229450 21611 110337866
Psychomotor hyperactivity 450.32 11.94 358 229464 19919 110339558
Headache 448.06 11.94 715 229107 881662 109477815
Blood prolactin increased 446.64 11.94 210 229612 4432 110355045
Swelling 433.66 11.94 99 229723 350942 110008535
Drug hypersensitivity 433.03 11.94 201 229621 453889 109905588
Nasopharyngitis 426.13 11.94 144 229678 394217 109965260
Mental impairment 421.88 11.94 361 229461 22278 110337199
Dyspnoea 421.61 11.94 1061 228761 1105811 109253666
Abdominal discomfort 414.95 11.94 150 229672 393708 109965769
Sinusitis 412.82 11.94 62 229760 296626 110062851
Diarrhoea 406.14 11.94 1129 228693 1138376 109221101
Hypersensitivity 403.87 11.94 167 229655 403831 109955646
Fatigue 399.99 11.94 1251 228571 1214707 109144770
Urticaria 395.68 11.94 89 229733 318768 110040709
Pneumonia aspiration 370.26 11.94 631 229191 80602 110278875
Pleurothotonus 369.91 11.94 153 229669 2345 110357132
Glossodynia 369.81 11.94 23 229799 221981 110137496
Peripheral swelling 362.32 11.94 194 229628 403840 109955637
Psoriatic arthropathy 358.47 11.94 11 229811 196750 110162727
Systemic lupus erythematosus 347.33 11.94 56 229766 254282 110105195
Duodenal ulcer perforation 334.82 11.94 7 229815 177693 110181784
Hallucination 334.77 11.94 686 229136 100746 110258731
Antipsychotic drug level increased 325.38 11.94 195 229627 6820 110352657
Disorientation 316.85 11.94 545 229277 70126 110289351
Pain in extremity 316.81 11.94 327 229495 486791 109872686
Irritability 314.36 11.94 440 229382 47369 110312108
Stomatitis 312.85 11.94 87 229735 270155 110089322
Folliculitis 310.47 11.94 8 229814 167645 110191832
Persecutory delusion 310.42 11.94 182 229640 6109 110353368
Blister 308.37 11.94 51 229771 227325 110132152
Alopecia 296.24 11.94 197 229625 364556 109994921
Contraindicated product administered 294.80 11.94 76 229746 248191 110111286
Social avoidant behaviour 288.00 11.94 164 229658 5205 110354272
Obsessive-compulsive disorder 284.30 11.94 181 229641 7060 110352417
Osteoarthritis 281.43 11.94 27 229795 182596 110176881
Impaired healing 278.47 11.94 39 229783 196678 110162799
Fibromyalgia 277.88 11.94 20 229802 170889 110188588
Respiratory depression 276.56 11.94 337 229485 31664 110327813
Asthma 276.20 11.94 88 229734 250203 110109274
Priapism 266.87 11.94 161 229661 5700 110353777
Cough 266.47 11.94 341 229481 461300 109898177
Diabetes mellitus 257.52 11.94 610 229212 98771 110260706
Wound 255.89 11.94 84 229738 234353 110125124
Sinus tachycardia 253.98 11.94 383 229439 44110 110315367
Bradyphrenia 251.75 11.94 203 229619 11525 110347952
Psychomotor retardation 250.67 11.94 172 229650 7620 110351857
Therapeutic product effect decreased 250.54 11.94 97 229725 244219 110115258
Irritable bowel syndrome 248.54 11.94 26 229796 164189 110195288
Schizoaffective disorder 247.83 11.94 124 229698 3012 110356465
Febrile neutropenia 247.23 11.94 1305 228517 315462 110044015
Leukopenia 246.78 11.94 775 229047 148016 110211461
Drug intolerance 244.33 11.94 291 229531 406221 109953256
Increased appetite 243.40 11.94 221 229601 14756 110344721
Arthritis 242.50 11.94 31 229791 167555 110191922
Polydipsia 240.95 11.94 167 229655 7521 110351956
Mobility decreased 238.96 11.94 97 229725 237325 110122152
Blood glucose increased 232.62 11.94 704 229118 131792 110227685
Neutropenia 232.55 11.94 1452 228370 373168 109986309
Back pain 232.23 11.94 257 229565 370739 109988738
Mental disorder 231.56 11.94 341 229481 38450 110321027
C-reactive protein abnormal 230.08 11.94 9 229813 129686 110229791
Inflammation 229.68 11.94 59 229763 193179 110166298
Lower respiratory tract infection 229.39 11.94 109 229713 242997 110116480
Apathy 228.14 11.94 221 229601 16018 110343459
Confusional state 224.26 11.94 1704 228118 466976 109892501
Cardio-respiratory arrest 223.94 11.94 637 229185 115199 110244278
Antipsychotic drug level above therapeutic 221.33 11.94 106 229716 2334 110357143
Joint range of motion decreased 221.20 11.94 7 229815 121825 110237652
Orthostatic hypertension 218.71 11.94 82 229740 953 110358524
Galactorrhoea 217.73 11.94 125 229697 4030 110355447
Bursitis 217.70 11.94 13 229809 129905 110229572
Thinking abnormal 216.38 11.94 208 229614 14932 110344545
Intentional product use issue 216.34 11.94 123 229699 247783 110111694
Infection 215.80 11.94 261 229561 361939 109997538
Emotional poverty 214.70 11.94 81 229741 959 110358518
Musculoskeletal pain 211.63 11.94 59 229763 182964 110176513
Muscle injury 211.28 11.94 23 229799 140784 110218693
Gastrointestinal disorder 211.21 11.94 120 229702 241832 110117645
Bradykinesia 211.20 11.94 177 229645 10611 110348866
Generalised tonic-clonic seizure 208.45 11.94 393 229429 54287 110305190
Diabetic ketoacidosis 208.05 11.94 339 229483 41719 110317758
Poisoning deliberate 207.85 11.94 265 229557 26066 110333411
Granulocytopenia 203.46 11.94 186 229636 12529 110346948
Loss of consciousness 203.42 11.94 878 228944 195428 110164049
Hypoaesthesia 200.69 11.94 214 229608 314009 110045468
Hallucination, visual 198.31 11.94 321 229501 39284 110320193
Psychiatric decompensation 196.75 11.94 132 229690 5633 110353844
Cogwheel rigidity 195.78 11.94 112 229710 3586 110355891
Speech disorder 195.58 11.94 410 229412 61159 110298318
Seizure 195.51 11.94 944 228878 220241 110139236
Hyponatraemia 194.61 11.94 932 228890 216721 110142756
Pericarditis 193.66 11.94 107 229715 219007 110140470
Sleep disorder due to general medical condition, insomnia type 192.04 11.94 6 229816 105637 110253840
Hallucinations, mixed 191.98 11.94 153 229669 8540 110350937
Anxiety 190.60 11.94 1299 228523 343779 110015698
Hyperthermia 188.67 11.94 227 229595 21045 110338432
Negativism 186.89 11.94 71 229751 858 110358619
Unresponsive to stimuli 184.53 11.94 409 229413 63381 110296096
Neutrophil count increased 183.32 11.94 288 229534 34364 110325113
Injection site pain 181.78 11.94 71 229751 177851 110181626
Altered state of consciousness 179.85 11.94 381 229441 57245 110302232
Blood triglycerides increased 179.78 11.94 235 229587 23691 110335786
Substance abuse 179.59 11.94 172 229650 12291 110347186
Ill-defined disorder 178.68 11.94 52 229770 156801 110202676
Disinhibition 176.94 11.94 99 229723 3035 110356442
Respiratory arrest 176.83 11.94 381 229441 57918 110301559
Discomfort 175.51 11.94 115 229707 214592 110144885
Lip dry 174.01 11.94 8 229814 100075 110259402
Night sweats 173.07 11.94 34 229788 133949 110225528
Affective disorder 171.26 11.94 160 229662 11081 110348396
Wheezing 169.55 11.94 168 229654 255062 110104415
Pulmonary embolism 169.55 11.94 887 228935 213587 110145890
Sciatica 168.86 11.94 5 229817 92394 110267083
Bipolar disorder 166.52 11.94 143 229679 8864 110350613
Drug ineffective 166.45 11.94 4231 225591 1516309 108843168
Delusion of grandeur 165.85 11.94 85 229737 2175 110357302
Camptocormia 165.65 11.94 55 229767 433 110359044
Disturbance in attention 165.44 11.94 385 229437 61610 110297867
Injury 164.88 11.94 81 229741 177184 110182293
Euphoric mood 162.90 11.94 140 229682 8687 110350790
Jaundice cholestatic 160.21 11.94 174 229648 14434 110345043
Posture abnormal 159.63 11.94 105 229717 4333 110355144
Urinary retention 159.58 11.94 408 229414 69275 110290202
Cognitive disorder 159.25 11.94 471 229351 87040 110272437
Erythema 159.18 11.94 224 229598 291223 110068254
Abdominal pain upper 158.34 11.94 303 229519 348808 110010669
Peripheral venous disease 155.76 11.94 4 229818 84113 110275364
Psychiatric symptom 155.73 11.94 139 229683 9074 110350403
Poisoning 155.49 11.94 243 229579 28862 110330615
Lung disorder 153.27 11.94 92 229730 179955 110179522
Accidental death 150.43 11.94 106 229716 4903 110354574
Contusion 150.00 11.94 158 229664 233203 110126274
Product dose omission issue 147.92 11.94 277 229545 321505 110037972
Dyslipidaemia 147.57 11.94 174 229648 15791 110343686
Cardiac arrest 147.51 11.94 802 229020 195951 110163526
Antipsychotic drug level below therapeutic 147.20 11.94 72 229750 1663 110357814
Muscle spasms 146.78 11.94 219 229603 277938 110081539
Wound infection 146.66 11.94 15 229807 96450 110263027
Psoriasis 146.11 11.94 54 229768 139939 110219538
Drooling 145.71 11.94 120 229702 7019 110352458
Pulmonary fibrosis 144.92 11.94 20 229802 102022 110257455
Anticholinergic syndrome 143.67 11.94 97 229725 4183 110355294
Grip strength decreased 140.73 11.94 6 229816 80168 110279309
Mutism 137.84 11.94 84 229738 3029 110356448
Nausea 137.70 11.94 1778 228044 1233912 109125565
Migraine 136.18 11.94 95 229727 171557 110187920
Product use issue 135.74 11.94 277 229545 311418 110048059
Paraesthesia 135.22 11.94 229 229593 276292 110083185
Eosinophil count decreased 135.21 11.94 107 229715 5911 110353566
Sudden death 134.97 11.94 207 229615 24188 110335289
Obsessive thoughts 134.66 11.94 62 229760 1245 110358232
Gestational diabetes 133.94 11.94 116 229706 7273 110352204
Obsessive-compulsive symptom 131.64 11.94 42 229780 287 110359190
Self-injurious ideation 130.58 11.94 92 229730 4254 110355223
Maternal exposure during pregnancy 130.32 11.94 205 229617 254678 110104799
Withdrawal syndrome 128.97 11.94 233 229589 31147 110328330
Injection site erythema 127.90 11.94 21 229801 94155 110265322
Inspiratory capacity decreased 127.84 11.94 75 229747 2520 110356957
Inappropriate antidiuretic hormone secretion 127.40 11.94 242 229580 33609 110325868
Megacolon 126.73 11.94 90 229732 4215 110355262
Intentional product misuse 124.49 11.94 577 229245 132327 110227150
Diabetic coma 119.76 11.94 58 229764 1310 110358167
White blood cell count decreased 118.59 11.94 850 228972 228540 110130937
Mental status changes 118.42 11.94 388 229434 75734 110283743
Hypertonia 117.33 11.94 114 229708 8292 110351185
Total lung capacity increased 115.09 11.94 91 229731 5021 110354456
Muscular weakness 114.94 11.94 213 229609 248255 110111222
Aplastic anaemia 114.92 11.94 192 229630 24116 110335361
Anaphylactic reaction 114.47 11.94 47 229775 114253 110245224
Hyperammonaemia 114.42 11.94 142 229680 13590 110345887
Agranulocytosis 113.88 11.94 334 229488 61426 110298051
Lower limb fracture 113.81 11.94 12 229810 75336 110284141
Mydriasis 112.85 11.94 181 229641 21976 110337501
Refusal of treatment by patient 112.80 11.94 118 229704 9376 110350101
Knee arthroplasty 110.33 11.94 6 229816 64942 110294535
Malaise 108.72 11.94 884 228938 670935 109688542
Neutrophil count decreased 107.38 11.94 517 229305 120424 110239053
Tension 107.09 11.94 87 229735 4991 110354486
Dyspepsia 106.00 11.94 145 229677 190820 110168657
Herpes zoster 104.65 11.94 47 229775 108332 110251145
Nail disorder 102.81 11.94 4 229818 57931 110301546
Rebound psychosis 102.69 11.94 37 229785 381 110359096
Sedation complication 102.23 11.94 163 229659 19692 110339785
Polydipsia psychogenic 102.10 11.94 35 229787 307 110359170
Hyperammonaemic encephalopathy 101.94 11.94 87 229735 5347 110354130
Amenorrhoea 101.31 11.94 110 229712 9121 110350356
Osteoporosis 100.89 11.94 28 229794 87124 110272353
Hypertriglyceridaemia 100.75 11.94 145 229677 16009 110343468
Injection site reaction 100.56 11.94 30 229792 89040 110270437
Abdominal pain 100.41 11.94 639 229183 512350 109847127
Drug withdrawal syndrome 100.07 11.94 235 229587 37819 110321658
Liver injury 99.86 11.94 99 229723 150314 110209163
Dyspnoea exertional 99.12 11.94 46 229776 104014 110255463
Weight decreased 98.96 11.94 569 229253 467488 109891989
Torticollis 98.68 11.94 69 229753 3152 110356325
Torsade de pointes 98.27 11.94 172 229650 22428 110337049
Myoclonus 98.16 11.94 214 229608 32784 110326693
Asthma-chronic obstructive pulmonary disease overlap syndrome 98.00 11.94 91 229731 6253 110353224
Cholelithiasis 97.51 11.94 322 229500 63100 110296377
Autoimmune disorder 97.45 11.94 11 229811 65472 110294005
Chest discomfort 96.49 11.94 132 229690 173716 110185761
White blood cell count increased 96.32 11.94 428 229394 96414 110263063
Behaviour disorder 95.63 11.94 109 229713 9538 110349939
Depressive symptom 95.39 11.94 102 229720 8312 110351165
Influenza 95.27 11.94 127 229695 168974 110190503
Apraxia 95.07 11.94 70 229752 3470 110356007
General physical health deterioration 93.16 11.94 511 229311 424784 109934693
Haematochezia 92.86 11.94 63 229759 115461 110244016
Frequent bowel movements 92.43 11.94 18 229804 71372 110288105
Treatment failure 92.14 11.94 283 229539 276951 110082526
Coma scale abnormal 91.55 11.94 107 229715 9619 110349858
Hyperphagia 90.74 11.94 68 229754 3463 110356014
Hallucination, olfactory 90.05 11.94 37 229785 557 110358920
Leukocytosis 88.83 11.94 280 229542 53548 110305929
Hyperglycaemia 88.38 11.94 381 229441 84709 110274768
Oedema 87.69 11.94 191 229631 209785 110149692
Drug level increased 86.95 11.94 257 229565 47462 110312015
Abulia 86.68 11.94 46 229776 1267 110358210
Ileus paralytic 86.19 11.94 114 229708 11623 110347854
Blunted affect 86.15 11.94 35 229787 511 110358966
Type 1 diabetes mellitus 85.94 11.94 100 229722 8947 110350530
Malignant neoplasm progression 85.83 11.94 144 229678 174423 110185054
Acute psychosis 85.80 11.94 76 229746 4911 110354566
Musculoskeletal stiffness 85.14 11.94 297 229525 279525 110079952
Electroencephalogram abnormal 84.82 11.94 83 229739 6090 110353387
Upper respiratory tract infection 84.27 11.94 89 229733 131239 110228238
Neck pain 84.11 11.94 79 229743 123051 110236426
Hip arthroplasty 84.01 11.94 9 229813 55804 110303673
Anaemia 83.87 11.94 730 229092 546356 109813121
Asphyxia 83.44 11.94 124 229698 14091 110345386
Bronchitis 83.41 11.94 123 229699 156909 110202568
Injection site pruritus 83.29 11.94 6 229816 51252 110308225
Skin exfoliation 83.09 11.94 39 229783 87612 110271865
Live birth 82.94 11.94 21 229801 69463 110290014
Prescribed overdose 82.56 11.94 381 229441 87200 110272277
Interstitial lung disease 82.26 11.94 101 229721 139233 110220244
COVID-19 81.54 11.94 250 229572 244810 110114667
Cardiac failure congestive 81.46 11.94 117 229705 150883 110208594
Feeling hot 81.17 11.94 44 229778 91062 110268415
Grandiosity 80.81 11.94 34 229788 545 110358932
Foot deformity 80.75 11.94 5 229817 48475 110311002
Injection site bruising 80.50 11.94 7 229815 51256 110308221
Refusal of examination 80.40 11.94 27 229795 221 110359256
Faecaloma 80.37 11.94 125 229697 14783 110344694
Drug resistance 80.31 11.94 279 229543 56095 110303382
Logorrhoea 80.26 11.94 73 229749 4884 110354593
Brain injury 79.74 11.94 118 229704 13358 110346119
Stupor 79.59 11.94 92 229730 8173 110351304
Gait inability 79.31 11.94 100 229722 136276 110223201
Substance-induced psychotic disorder 78.42 11.94 75 229747 5349 110354128
Illusion 78.37 11.94 50 229772 1957 110357520
Autonomic nervous system imbalance 78.08 11.94 77 229745 5703 110353774
Arrhythmia 78.08 11.94 319 229503 69256 110290221
Paradoxical drug reaction 77.79 11.94 99 229723 9718 110349759
Depressed mood 77.32 11.94 290 229532 60519 110298958
Disorganised speech 76.95 11.94 60 229762 3243 110356234
Impulsive behaviour 76.76 11.94 60 229762 3255 110356222
Drug use disorder 76.57 11.94 136 229686 17938 110341539
Feeling guilty 76.51 11.94 38 229784 908 110358569
Lethargy 75.95 11.94 390 229432 93186 110266291
Polyuria 75.83 11.94 134 229688 17604 110341873
Asthenia 75.47 11.94 994 228828 688005 109671472
Antipsychotic drug level decreased 75.38 11.94 43 229779 1369 110358108
Heat stroke 75.05 11.94 48 229774 1887 110357590
Resting tremor 75.03 11.94 46 229776 1677 110357800
Gastrointestinal haemorrhage 74.67 11.94 144 229678 165374 110194103
Road traffic accident 74.42 11.94 68 229754 107330 110252147
Spasmodic dysphonia 74.40 11.94 32 229790 543 110358934
Blood pressure increased 74.13 11.94 281 229541 258092 110101385
Rectal haemorrhage 73.80 11.94 84 229738 119749 110239728
Fluid retention 73.72 11.94 53 229769 94254 110265223
Withdrawal catatonia 73.67 11.94 29 229793 388 110359089
Somnambulism 73.24 11.94 78 229744 6327 110353150
Exostosis 72.92 11.94 6 229816 45950 110313527
Pressure of speech 72.28 11.94 41 229781 1291 110358186
Screaming 71.53 11.94 68 229754 4813 110354664
Illness 71.31 11.94 41 229781 82130 110277347
Hyperreflexia 71.00 11.94 93 229729 9392 110350085
Chest pain 70.97 11.94 474 229348 375901 109983576
Flat affect 70.60 11.94 51 229771 2454 110357023
Rash pruritic 70.48 11.94 60 229762 98009 110261468
Back injury 70.44 11.94 8 229814 47391 110312086
Major depression 70.17 11.94 98 229724 10523 110348954
Bipolar I disorder 70.16 11.94 49 229773 2234 110357243
Delusional disorder, unspecified type 69.73 11.94 35 229787 856 110358621
Reduced facial expression 69.61 11.94 59 229763 3592 110355885
Impulse-control disorder 69.56 11.94 48 229774 2146 110357331
Gynaecomastia 69.42 11.94 92 229730 9398 110350079
Skin ulcer 69.06 11.94 23 229799 63622 110295855
Head titubation 68.91 11.94 40 229782 1317 110358160
Food craving 68.68 11.94 46 229776 1957 110357520
Lupus-like syndrome 68.57 11.94 4 229818 40788 110318689
Hepatic enzyme increased 68.36 11.94 389 229433 320503 110038974
Delusional disorder, persecutory type 68.22 11.94 31 229791 603 110358874
Productive cough 67.32 11.94 83 229739 114222 110245255
Water intoxication 67.30 11.94 35 229787 924 110358553
Cataract 67.08 11.94 41 229781 79444 110280033
Pancreatitis necrotising 66.48 11.94 69 229753 5432 110354045
Adjustment disorder with depressed mood 66.24 11.94 7 229815 43876 110315601
Ear infection 65.78 11.94 24 229798 62708 110296769
Hepatocellular injury 65.63 11.94 243 229579 50399 110309078
Suspiciousness 65.58 11.94 32 229790 735 110358742
Colitis ulcerative 65.16 11.94 40 229782 77323 110282154
Paroxysmal perceptual alteration 65.03 11.94 24 229798 266 110359211
Waxy flexibility 64.24 11.94 24 229798 276 110359201
Injection site swelling 64.18 11.94 24 229798 61766 110297711
Thrombosis 63.89 11.94 79 229743 108583 110250894
Nasal congestion 63.73 11.94 66 229756 98216 110261261
Urinary tract infection 63.48 11.94 407 229415 325875 110033602
Sexually inappropriate behaviour 63.46 11.94 30 229792 641 110358836
Pneumonia 62.97 11.94 1366 228456 875348 109484129
Lymphocyte count abnormal 62.97 11.94 47 229775 2379 110357098
Disease progression 62.74 11.94 277 229545 243757 110115720
Stereotypy 62.57 11.94 34 229788 983 110358494
Atrial fibrillation 62.52 11.94 255 229567 229387 110130090
Ataxia 62.51 11.94 170 229652 29938 110329539
Oral herpes 62.34 11.94 3 229819 36077 110323400
Joint stiffness 62.09 11.94 31 229791 67212 110292265
Cerebellar atrophy 61.26 11.94 38 229784 1415 110358062
Throat irritation 60.52 11.94 18 229804 53534 110305943
Nephrolithiasis 60.42 11.94 31 229791 66181 110293296
Bezoar 60.41 11.94 57 229765 3997 110355480
Trimethylaminuria 60.30 11.94 21 229801 194 110359283
Dry mouth 60.28 11.94 213 229609 199735 110159742
Staring 59.84 11.94 49 229773 2843 110356634
Negative symptoms in schizophrenia 59.83 11.94 21 229801 199 110359278
Personality change due to a general medical condition 59.52 11.94 23 229799 292 110359185
Decreased appetite 59.45 11.94 667 229155 475179 109884298
Myelosuppression 59.33 11.94 65 229757 94275 110265202
Hyperhidrosis 58.92 11.94 622 229200 186676 110172801
Pulmonary mass 58.82 11.94 5 229817 37296 110322181
Electrocardiogram abnormal 58.71 11.94 124 229698 18585 110340892
Fungal infection 57.55 11.94 17 229805 50789 110308688
Intestinal pseudo-obstruction 57.45 11.94 51 229771 3305 110356172
Encephalitis autoimmune 57.21 11.94 52 229770 3476 110356001
Urinary incontinence 57.09 11.94 226 229596 48361 110311116
Myalgia 56.81 11.94 253 229569 222128 110137349
Hyperventilation 56.81 11.94 81 229741 8866 110350611
Delusion of reference 56.80 11.94 21 229801 234 110359243
Gaze palsy 56.79 11.94 51 229771 3356 110356121
Laryngitis 56.39 11.94 10 229812 42401 110317076
Aspiration 56.16 11.94 165 229657 30368 110329109
Enuresis 56.14 11.94 55 229767 4041 110355436
Eosinophil count increased 55.32 11.94 130 229692 20928 110338549
Delusion of replacement 55.18 11.94 21 229801 255 110359222
Taste disorder 54.80 11.94 34 229788 65353 110294124
Product quality issue 54.69 11.94 48 229774 77251 110282226
Sleep disorder due to a general medical condition 54.53 11.94 20 229802 52092 110307385
Soliloquy 54.09 11.94 31 229791 996 110358481
Therapeutic product effect variable 54.04 11.94 45 229777 2673 110356804
Substance use disorder 53.83 11.94 71 229751 7219 110352258
Sarcoidosis 53.74 11.94 95 229727 12484 110346993
Onychomycosis 53.66 11.94 8 229814 38523 110320954
Cytomegalovirus infection 53.52 11.94 23 229799 54421 110305056
Eosinophilic myocarditis 53.24 11.94 40 229782 2045 110357432
Ear pain 53.10 11.94 22 229800 53204 110306273
Osteonecrosis of jaw 52.72 11.94 17 229805 48000 110311477
Movement disorder 52.57 11.94 181 229641 36223 110323254
Erectile dysfunction 52.55 11.94 118 229704 18438 110341039
Psychomotor skills impaired 52.52 11.94 69 229753 6989 110352488
Hypernatraemia 52.30 11.94 115 229707 17718 110341759
Hypokinesia 52.26 11.94 130 229692 21696 110337781
Loss of personal independence in daily activities 52.08 11.94 150 229672 149870 110209607
Long QT syndrome 52.06 11.94 69 229753 7049 110352428
Rhinorrhoea 52.03 11.94 83 229739 102583 110256894
Somatic symptom disorder of pregnancy 51.92 11.94 16 229806 96 110359381
Hypertension 51.81 11.94 747 229075 509337 109850140
Bone pain 51.70 11.94 36 229786 65097 110294380
Eosinophilia 51.64 11.94 248 229574 57688 110301789
Consciousness fluctuating 51.40 11.94 40 229782 2156 110357321
Hypersexuality 51.28 11.94 38 229784 1902 110357575
Sinus congestion 51.16 11.94 3 229819 30456 110329021
Alcohol abuse 51.09 11.94 57 229765 4872 110354605
Condition aggravated 51.03 11.94 1937 227885 732899 109626578
Chills 51.01 11.94 213 229609 190367 110169110
Procedural pain 50.42 11.94 7 229815 35558 110323919
Dementia with Lewy bodies 50.39 11.94 30 229792 1036 110358441
Anaphylactic shock 50.31 11.94 22 229800 51524 110307953
Malignant catatonia 50.21 11.94 26 229796 680 110358797
Hyperglycaemic hyperosmolar nonketotic syndrome 50.07 11.94 45 229777 2964 110356513
Neuralgia 50.07 11.94 19 229803 48459 110311018
Stress 49.86 11.94 89 229733 105259 110254218
Cardiomyopathy 49.56 11.94 168 229654 33357 110326120
Overweight 49.35 11.94 64 229758 6400 110353077
Oromandibular dystonia 49.17 11.94 31 229791 1188 110358289
Haematuria 49.16 11.94 60 229762 82945 110276532
Device expulsion 49.10 11.94 4 229818 30887 110328590
Flushing 49.10 11.94 89 229733 104647 110254830
Alanine aminotransferase increased 49.06 11.94 591 229231 183182 110176295
Compartment syndrome 49.06 11.94 61 229761 5849 110353628
Bundle branch block right 48.90 11.94 90 229732 12201 110347276
Inappropriate affect 48.82 11.94 35 229787 1664 110357813
Abnormal weight gain 48.81 11.94 48 229774 3543 110355934
Dysphagia 48.73 11.94 511 229311 153089 110206388
Angina pectoris 48.70 11.94 35 229787 62260 110297217
Eczema 48.64 11.94 47 229775 72246 110287231
Neuropathy peripheral 48.21 11.94 200 229622 179077 110180400
Liver disorder 48.09 11.94 144 229678 142099 110217378
Dysphoria 48.08 11.94 63 229759 6365 110353112
C-reactive protein 48.01 11.94 4 229818 30327 110329150
Insurance issue 47.75 11.94 82 229740 10530 110348947
Troponin increased 47.43 11.94 153 229669 29613 110329864
Paraesthesia oral 46.87 11.94 7 229815 33664 110325813
Drug therapy enhancement 46.31 11.94 13 229809 53 110359424
Anxiolytic therapy 46.31 11.94 13 229809 53 110359424
Gamma-glutamyltransferase increased 45.96 11.94 250 229572 61059 110298418
High density lipoprotein decreased 45.72 11.94 58 229764 5675 110353802
Cor pulmonale acute 45.63 11.94 25 229797 735 110358742
Accidental overdose 45.57 11.94 221 229601 51613 110307864
Nasal polyps 45.56 11.94 91 229731 13109 110346368
Oral candidiasis 45.47 11.94 18 229804 44742 110314735
Chronic kidney disease 45.34 11.94 55 229767 76236 110283241
Embolism venous 45.19 11.94 54 229768 4969 110354508
Alcohol use 45.03 11.94 49 229773 4073 110355404
Colitis ischaemic 44.92 11.94 108 229714 17642 110341835
Hypotension 44.62 11.94 1414 228408 522435 109837042
Suicidal behaviour 44.32 11.94 45 229777 3452 110356025
Homicide 44.30 11.94 28 229794 1078 110358399
Depression 44.26 11.94 915 228907 316420 110043057
Gout 43.74 11.94 11 229811 36555 110322922
Head banging 43.54 11.94 22 229800 546 110358931
Tobacco interaction 43.32 11.94 15 229807 136 110359341
Diverticulitis 43.26 11.94 29 229793 53493 110305984
Wrong patient received product 43.23 11.94 61 229761 6613 110352864
Blood pressure systolic increased 43.10 11.94 66 229756 82925 110276552
Body mass index increased 43.09 11.94 37 229785 2293 110357184
Ventricular arrhythmia 42.86 11.94 76 229746 10011 110349466
Diet refusal 42.64 11.94 25 229797 839 110358638
Self esteem decreased 42.47 11.94 27 229795 1050 110358427
Blood bilirubin increased 42.44 11.94 287 229535 75685 110283792
Therapy partial responder 42.43 11.94 171 229651 36890 110322587
Breast engorgement 42.35 11.94 12 229810 51 110359426
Cystitis 42.08 11.94 45 229777 65991 110293486
Device issue 42.07 11.94 10 229812 34525 110324952
Prostate cancer 41.90 11.94 13 229809 37628 110321849
Red blood cell sedimentation rate increased 41.89 11.94 61 229761 78241 110281236
Hypersomnia 41.82 11.94 141 229681 27920 110331557
Hanging 41.70 11.94 16 229806 199 110359278
Rhinalgia 41.69 11.94 46 229776 3883 110355594
Diabetic hyperosmolar coma 41.64 11.94 25 229797 877 110358600
Troponin T increased 41.58 11.94 48 229774 4258 110355219
Brain stem thrombosis 41.43 11.94 8 229814 0 110359477
Echolalia 41.24 11.94 21 229801 530 110358947
Rhinitis allergic 41.08 11.94 105 229717 17817 110341660
Oropharyngeal pain 40.83 11.94 144 229678 135132 110224345
Incoherent 40.82 11.94 67 229755 8291 110351186
Retrograde ejaculation 40.80 11.94 19 229803 392 110359085
Orthostatic hypotension 40.50 11.94 256 229566 65993 110293484
Food refusal 40.44 11.94 25 229797 925 110358552
Insomnia 40.38 11.94 1008 228814 359582 109999895
Communication disorder 40.22 11.94 51 229771 4988 110354489
Compulsive sexual behaviour 40.21 11.94 17 229805 276 110359201
Sluggishness 40.17 11.94 63 229759 7504 110351973
Anger 40.14 11.94 108 229714 18899 110340578
Ejaculation disorder 40.08 11.94 21 229801 563 110358914
Clonus 40.07 11.94 68 229754 8648 110350829
Antisocial behaviour 39.92 11.94 24 229798 844 110358633
Prescribed underdose 39.78 11.94 46 229776 65128 110294349
Multiple sclerosis relapse 39.57 11.94 28 229794 50212 110309265
Affect lability 39.46 11.94 106 229716 18531 110340946
Melaena 39.36 11.94 51 229771 68706 110290771
Visceral congestion 39.32 11.94 28 229794 1317 110358160
Ascites 39.08 11.94 84 229738 92724 110266753
Akinesia 39.03 11.94 43 229779 3624 110355853
Hypotonia 38.99 11.94 95 229727 15650 110343827
Aspergillus infection 38.89 11.94 4 229818 25612 110333865
Physical assault 38.86 11.94 30 229792 1598 110357879
Somatic symptom disorder 38.85 11.94 40 229782 3119 110356358
Immunodeficiency 38.83 11.94 16 229806 38822 110320655
Dissociative disorder 38.79 11.94 27 229795 1224 110358253
Sinus bradycardia 38.64 11.94 142 229680 29341 110330136
Dry skin 38.57 11.94 106 229716 107547 110251930
Postural tremor 38.32 11.94 25 229797 1017 110358460
Cyclothymic disorder 38.23 11.94 16 229806 253 110359224
Drug dependence 38.19 11.94 205 229617 49815 110309662
Surgery 38.16 11.94 19 229803 41264 110318213
Hepatotoxicity 38.14 11.94 244 229578 63156 110296321
Phagophobia 38.05 11.94 11 229811 51 110359426
Death 37.74 11.94 1135 228687 697734 109661743
Sneezing 37.53 11.94 10 229812 31974 110327503
Gastrointestinal sounds abnormal 37.50 11.94 54 229768 5964 110353513
Respiratory tract congestion 37.46 11.94 9 229813 30848 110328629
Judgement impaired 37.30 11.94 27 229795 1303 110358174
Rash erythematous 37.07 11.94 71 229751 81761 110277716
Toxic encephalopathy 36.83 11.94 91 229731 15123 110344354
Tachyphrenia 36.79 11.94 34 229788 2322 110357155
Respiratory alkalosis 36.63 11.94 52 229770 5669 110353808
Aspartate aminotransferase increased 36.61 11.94 500 229322 159436 110200041
Skin discolouration 36.49 11.94 29 229793 49017 110310460
Pleural effusion 36.44 11.94 218 229604 177491 110181986
Hypometabolism 36.28 11.94 14 229808 177 110359300
Myocardial reperfusion injury 36.24 11.94 13 229809 132 110359345
Epistaxis 35.95 11.94 144 229678 130228 110229249
Slow speech 35.95 11.94 40 229782 3408 110356069
Derealisation 35.37 11.94 32 229790 2126 110357351
Product substitution issue 35.36 11.94 117 229705 22944 110336533
Ulcer 35.33 11.94 23 229799 43093 110316384
Localised infection 35.23 11.94 23 229799 43025 110316452
Thought blocking 34.90 11.94 15 229807 254 110359223
Electrocardiogram QRS complex prolonged 34.88 11.94 81 229741 12940 110346537
Abdominal distension 34.76 11.94 217 229605 174886 110184591
Hostility 34.73 11.94 35 229787 2661 110356816
Apallic syndrome 34.60 11.94 24 229798 1082 110358395
Blood pressure diastolic abnormal 34.51 11.94 6 229816 25809 110333668
Psychosexual disorder 34.45 11.94 13 229809 154 110359323
Panic attack 34.31 11.94 135 229687 28805 110330672
Dysphonia 34.28 11.94 66 229756 75863 110283614
Skin fissures 34.24 11.94 5 229817 24453 110335024
Adrenal insufficiency 34.22 11.94 23 229799 42367 110317110
Dissociation 34.15 11.94 68 229754 9774 110349703
Kidney infection 34.11 11.94 6 229816 25593 110333884
Oscillopsia 33.90 11.94 17 229805 415 110359062
Macular degeneration 33.89 11.94 3 229819 21656 110337821
Tic 33.83 11.94 39 229783 3454 110356023
Candida infection 33.73 11.94 30 229792 47979 110311498
Dizziness 33.59 11.94 1151 228671 697042 109662435
Myelodysplastic syndrome 33.54 11.94 18 229804 37466 110322011
Encephalitis toxic 33.43 11.94 15 229807 283 110359194
Plasma cell mastitis 33.25 11.94 9 229813 31 110359446
Obsessive-compulsive personality disorder 33.18 11.94 12 229810 125 110359352
Gastrointestinal hypomotility 33.12 11.94 33 229789 2475 110357002
Ulcer haemorrhage 33.06 11.94 4 229818 22567 110336910
Bone marrow failure 33.02 11.94 43 229779 57805 110301672
Drug abuser 32.92 11.94 48 229774 5361 110354116
Brain oedema 32.86 11.94 140 229682 30958 110328519
Myocardial hypoxia 32.67 11.94 8 229814 16 110359461
Maternal exposure timing unspecified 32.64 11.94 3 229819 21010 110338467
Restless legs syndrome 32.60 11.94 119 229703 24507 110334970
Iatrogenic injury 32.54 11.94 27 229795 1596 110357881
Impaired self-care 32.50 11.94 33 229789 2531 110356946
Drug screen positive 32.14 11.94 52 229770 6358 110353119
Adverse event 32.06 11.94 117 229705 108692 110250785
Joint injury 31.88 11.94 22 229800 39972 110319505
Cerebrovascular accident 31.82 11.94 233 229589 181051 110178426
Drug monitoring procedure incorrectly performed 31.81 11.94 20 229802 763 110358714
Somatic hallucination 31.77 11.94 10 229812 65 110359412
Distractibility 31.64 11.94 21 229801 880 110358597
Adverse reaction 31.57 11.94 11 229811 29583 110329894
Haemophagocytic lymphohistiocytosis 31.55 11.94 13 229809 31546 110327931
Inappropriate schedule of product administration 31.46 11.94 271 229551 203366 110156111
Haemoptysis 31.37 11.94 63 229759 71291 110288186
Pain in jaw 31.37 11.94 36 229786 51141 110308336
Psychotic behaviour 31.29 11.94 25 229797 1400 110358077
Joint dislocation 31.21 11.94 16 229806 34174 110325303
Social problem 31.13 11.94 28 229794 1846 110357631
Neoplasm progression 31.08 11.94 54 229768 64541 110294936
Flight of ideas 31.05 11.94 20 229802 796 110358681
No adverse event 30.94 11.94 67 229755 73772 110285705
Product label confusion 30.91 11.94 5 229817 22672 110336805
Oral discharge 30.83 11.94 14 229808 272 110359205
International normalised ratio increased 30.67 11.94 86 229736 86686 110272791
Limb discomfort 30.59 11.94 24 229798 40830 110318647
Respiratory disorder 30.56 11.94 64 229758 71318 110288159
Cerebrovascular stenosis 30.39 11.94 12 229810 162 110359315
Breast discomfort 30.33 11.94 17 229805 523 110358954
Metastases to liver 30.21 11.94 18 229804 35368 110324109
Self-destructive behaviour 30.20 11.94 20 229802 835 110358642
Seasonal allergy 30.15 11.94 3 229819 19719 110339758
Corticobasal degeneration 30.14 11.94 8 229814 25 110359452
Rebound effect 30.14 11.94 83 229739 14723 110344754
Injection site rash 30.11 11.94 6 229816 23413 110336064
Hypophagia 30.11 11.94 200 229622 52426 110307051
Symptom recurrence 30.00 11.94 43 229779 4729 110354748
Plasma cell myeloma 29.93 11.94 53 229769 62883 110296594
Helplessness 29.88 11.94 15 229807 367 110359110
Basal cell carcinoma 29.80 11.94 30 229792 45240 110314237
Trismus 29.72 11.94 51 229771 6545 110352932
Renal failure 29.69 11.94 314 229508 226260 110133217
Pneumocystis jirovecii pneumonia 29.67 11.94 27 229795 42708 110316769
Limb injury 29.61 11.94 21 229801 37615 110321862
Posturing 29.54 11.94 22 229800 1110 110358367
Ketoacidosis 29.52 11.94 65 229757 10022 110349455
Chorea 29.47 11.94 35 229787 3200 110356277
Choreoathetosis 29.46 11.94 26 229796 1672 110357805
Cerebral atrophy 29.42 11.94 61 229761 9024 110350453
Discoloured vomit 29.37 11.94 28 229794 1989 110357488
Sepsis 29.26 11.94 491 229331 326855 110032622
Gambling disorder 29.25 11.94 29 229793 2162 110357315
Asocial behaviour 29.24 11.94 10 229812 87 110359390
Hyperkalaemia 29.22 11.94 164 229658 135632 110223845
Self-medication 29.16 11.94 49 229773 6183 110353294
Uveitis 29.12 11.94 5 229817 21705 110337772
Fear 28.97 11.94 110 229712 23083 110336394
Dysgeusia 28.92 11.94 64 229758 69921 110289556
Progressive multifocal leukoencephalopathy 28.91 11.94 8 229814 24948 110334529
Bradycardia 28.88 11.94 469 229353 155048 110204429
Burning sensation 28.84 11.94 63 229759 69149 110290328
Eye movement disorder 28.83 11.94 63 229759 9665 110349812
Hepatic steatosis 28.80 11.94 187 229635 48644 110310833
Obstructive airways disorder 28.79 11.94 32 229790 46117 110313360
Bladder cancer 28.75 11.94 4 229818 20288 110339189
Nodule 28.71 11.94 16 229806 32615 110326862
Device dislocation 28.69 11.94 15 229807 31689 110327788
Pulmonary arterial hypertension 28.61 11.94 16 229806 32552 110326925
Hepatitis C virus test positive 28.50 11.94 15 229807 406 110359071
Blood cholesterol increased 28.50 11.94 246 229576 184539 110174938
Hot flush 28.44 11.94 59 229763 65977 110293500
Perseveration 28.30 11.94 15 229807 412 110359065
Liver function test increased 28.26 11.94 92 229730 88456 110271021
Epstein-Barr virus infection 28.25 11.94 3 229819 18735 110340742
Urticaria cholinergic 28.15 11.94 9 229813 62 110359415
Drug tolerance decreased 28.10 11.94 11 229811 27529 110331948
Unevaluable event 28.05 11.94 50 229772 59177 110300300
Tenderness 28.05 11.94 13 229809 29424 110330053
Haemorrhoids 27.94 11.94 20 229802 35652 110323825
Glassy eyes 27.93 11.94 12 229810 203 110359274
Pseudohallucination 27.93 11.94 12 229810 203 110359274
Bradypnoea 27.93 11.94 58 229764 8591 110350886
Electrocardiogram QT interval abnormal 27.91 11.94 14 229808 342 110359135
Haemoglobin urine 27.89 11.94 11 229811 148 110359329
Tongue movement disturbance 27.83 11.94 16 229806 517 110358960
Flashback 27.81 11.94 15 229807 427 110359050
Drug level above therapeutic 27.72 11.94 69 229753 11519 110347958
Osteonecrosis 27.65 11.94 18 229804 33723 110325754
Breast enlargement 27.59 11.94 25 229797 1664 110357813
Thrombotic microangiopathy 27.58 11.94 13 229809 29136 110330341
Grimacing 27.50 11.94 19 229803 851 110358626
Dry eye 27.43 11.94 46 229776 55747 110303730
Coma scale 27.43 11.94 9 229813 68 110359409
Sleep disorder 27.38 11.94 272 229550 198372 110161105
Tendonitis 27.31 11.94 10 229812 26073 110333404
Palpitations 27.29 11.94 206 229616 159006 110200471
Manic symptom 27.28 11.94 13 229809 283 110359194
Tachypnoea 27.11 11.94 157 229665 39238 110320239
Troponin I increased 27.03 11.94 44 229778 5408 110354069
Electrocardiogram T wave inversion 27.03 11.94 45 229777 5635 110353842
Neuropsychiatric symptoms 27.02 11.94 22 229800 1266 110358211
Hypervolaemia 26.98 11.94 38 229784 49422 110310055
Haematocrit decreased 26.95 11.94 232 229590 65885 110293592
Cardiac murmur 26.90 11.94 112 229710 24516 110334961
Oral pain 26.79 11.94 23 229799 37421 110322056
Pulmonary hypertension 26.72 11.94 46 229776 55174 110304303
Gastrooesophageal reflux disease 26.70 11.94 242 229580 179734 110179743
Myasthenia gravis 26.66 11.94 6 229816 21505 110337972
Muscle twitching 26.57 11.94 128 229694 29807 110329670
Appendicitis 26.46 11.94 13 229809 28451 110331026
Pupillary reflex impaired 26.45 11.94 37 229785 3978 110355499
Cytomegalovirus viraemia 26.39 11.94 3 229819 17761 110341716
Homicidal ideation 26.28 11.94 35 229787 3592 110355885
Morose 26.25 11.94 8 229814 46 110359431
Infusion site reaction 26.23 11.94 3 229819 17679 110341798
Disease recurrence 26.21 11.94 216 229606 60568 110298909
Breath sounds abnormal 26.16 11.94 10 229812 25394 110334083
Snoring 26.14 11.94 49 229773 6735 110352742
Coronary artery disease 26.12 11.94 70 229752 71620 110287857
Parkinsonian gait 26.12 11.94 20 229802 1052 110358425
Palmar-plantar erythrodysaesthesia syndrome 26.09 11.94 28 229794 40997 110318480
Oropharyngeal spasm 26.09 11.94 15 229807 485 110358992
Bone disorder 26.08 11.94 6 229816 21186 110338291
Central nervous system lupus 26.07 11.94 22 229800 1331 110358146
Hypomagnesaemia 25.95 11.94 54 229768 60316 110299161
Full blood count abnormal 25.94 11.94 48 229774 56004 110303473
Intravascular papillary endothelial hyperplasia 25.89 11.94 5 229817 0 110359477
Hypoventilation 25.87 11.94 54 229768 8027 110351450
Violence-related symptom 25.84 11.94 19 229803 940 110358537
Bronchopulmonary aspergillosis 25.76 11.94 15 229807 29848 110329629
Ketosis-prone diabetes mellitus 25.68 11.94 8 229814 50 110359427
Walking aid user 25.61 11.94 10 229812 25065 110334412
Osteomyelitis 25.56 11.94 23 229799 36577 110322900
Lymphocyte count decreased 25.54 11.94 205 229617 57038 110302439
Faeces discoloured 25.34 11.94 20 229802 33928 110325549
Squamous cell carcinoma 25.33 11.94 4 229818 18459 110341018
Eosinophilic pleural effusion 25.33 11.94 15 229807 513 110358964
Blood sodium increased 25.27 11.94 43 229779 5480 110353997
Full blood count decreased 25.13 11.94 18 229804 32081 110327396
Eyelid function disorder 24.94 11.94 15 229807 528 110358949
Proctitis 24.79 11.94 3 229819 16924 110342553
Patient restraint 24.78 11.94 9 229813 95 110359382
Radiculopathy 24.77 11.94 5 229817 19331 110340146
Hypercholesterolaemia 24.62 11.94 101 229721 90736 110268741
Respiratory tract infection 24.56 11.94 72 229750 71545 110287932
Blood pressure diastolic decreased 24.53 11.94 23 229799 35862 110323615
Exhibitionism 24.43 11.94 8 229814 60 110359417
Mean cell haemoglobin concentration decreased 24.38 11.94 43 229779 5639 110353838
Renal impairment 24.35 11.94 262 229560 188183 110171294
Cataract cortical 24.31 11.94 10 229812 151 110359326
Substance use 24.31 11.94 28 229794 2478 110356999
Negative thoughts 24.25 11.94 23 229799 1623 110357854
Activation syndrome 24.20 11.94 13 229809 367 110359110
Swelling face 24.19 11.94 104 229718 92217 110267260
Hepatic cirrhosis 23.92 11.94 67 229755 67559 110291918
Psychotic disorder due to a general medical condition 23.89 11.94 12 229810 294 110359183
Electrocardiogram PR prolongation 23.88 11.94 24 229798 1819 110357658
Delusional disorder, erotomanic type 23.87 11.94 8 229814 65 110359412
Protrusion tongue 23.77 11.94 14 229808 474 110359003
Circulatory collapse 23.76 11.94 162 229660 42831 110316646
Blood pressure fluctuation 23.70 11.94 78 229744 74746 110284731
Joint effusion 23.67 11.94 7 229815 20898 110338579
Bacterial infection 23.53 11.94 37 229785 45999 110313478
Skin disorder 23.38 11.94 33 229789 42880 110316597
Xanthoma 23.35 11.94 11 229811 233 110359244
Symptom masked 23.32 11.94 24 229798 1871 110357606
Delusional perception 23.31 11.94 13 229809 396 110359081
Blood ethanol 23.31 11.94 9 229813 114 110359363
Dermatitis atopic 23.24 11.94 12 229810 25529 110333948
Neurological decompensation 23.22 11.94 47 229775 6836 110352641
Eye pain 23.10 11.94 43 229779 50056 110309421
Peptostreptococcus infection 23.02 11.94 10 229812 174 110359303
Pulmonary congestion 23.02 11.94 126 229696 30840 110328637
Product dose omission in error 23.00 11.94 10 229812 23502 110335975
Total cholesterol/HDL ratio increased 22.99 11.94 13 229809 407 110359070
Compulsions 22.99 11.94 13 229809 407 110359070
Skin necrosis 22.94 11.94 8 229814 21504 110337973
Hyporesponsive to stimuli 22.91 11.94 29 229793 2831 110356646
Neoplasm malignant 22.90 11.94 26 229796 37117 110322360
Sensory loss 22.85 11.94 8 229814 21449 110338028
Abnormal clotting factor 22.82 11.94 10 229812 178 110359299
Metastases to bone 22.77 11.94 19 229803 31353 110328124
Autism spectrum disorder 22.76 11.94 24 229798 1924 110357553
Lung neoplasm malignant 22.72 11.94 134 229688 33708 110325769
Butterfly rash 22.70 11.94 25 229797 2106 110357371
Hypoglycaemia 22.63 11.94 353 229469 115751 110243726
Anterograde amnesia 22.60 11.94 17 229805 871 110358606
Extrasystoles 22.56 11.94 52 229770 8266 110351211
Pregnancy 22.53 11.94 45 229777 51022 110308455
Ideas of reference 22.42 11.94 10 229812 186 110359291
Deafness 22.23 11.94 14 229808 26695 110332782
Vaginal discharge 22.18 11.94 5 229817 17903 110341574
Hyperarousal 22.17 11.94 7 229815 46 110359431
Rash macular 21.83 11.94 29 229793 38657 110320820
Heart rate decreased 21.82 11.94 93 229729 82663 110276814
Haemorrhage 21.81 11.94 131 229691 106561 110252916
Skin burning sensation 21.80 11.94 9 229813 21816 110337661
Choking 21.70 11.94 75 229747 15035 110344442
Congestive cardiomyopathy 21.68 11.94 72 229750 14147 110345330
Hypoxic-ischaemic encephalopathy 21.50 11.94 53 229769 8794 110350683
Cardiac failure 21.46 11.94 268 229554 187358 110172119
Agitated depression 21.39 11.94 14 229808 573 110358904
Tenosynovitis 21.30 11.94 4 229818 16279 110343198
Alcoholism 21.27 11.94 32 229790 3675 110355802
Cerebellar syndrome 21.22 11.94 43 229779 6259 110353218
Multiple organ dysfunction syndrome 21.21 11.94 207 229615 151503 110207974
Echopraxia 21.21 11.94 7 229815 54 110359423
Sinus disorder 21.19 11.94 22 229800 32706 110326771
Blood osmolarity increased 21.18 11.94 16 229806 825 110358652
Angioedema 21.17 11.94 119 229703 98381 110261096
Prolactin-producing pituitary tumour 21.02 11.94 9 229813 151 110359326
Rash papular 20.99 11.94 16 229806 27623 110331854
Hunger 20.99 11.94 44 229778 6560 110352917
Abdominal pain lower 20.99 11.94 28 229794 37255 110322222
Lacrimation increased 20.96 11.94 20 229802 30930 110328547
Gastric disorder 20.95 11.94 23 229799 33334 110326143
Acute kidney injury 20.95 11.94 1093 228729 634337 109725140
Muscle contractions involuntary 20.87 11.94 35 229787 4409 110355068
Thirst 20.87 11.94 95 229727 21612 110337865
Osteopenia 20.86 11.94 10 229812 22199 110337278
Secretion discharge 20.79 11.94 8 229814 20236 110339241
Chylomicron increased 20.71 11.94 4 229818 0 110359477
Fluid intake restriction 20.67 11.94 7 229815 59 110359418
Thermal burn 20.64 11.94 49 229773 7939 110351538
Pancreatitis haemorrhagic 20.57 11.94 17 229805 999 110358478
Hyperchylomicronaemia 20.56 11.94 7 229815 60 110359417
Trichoglossia 20.53 11.94 16 229806 864 110358613
Postmortem blood drug level 20.53 11.94 11 229811 309 110359168
Shock haemorrhagic 20.41 11.94 16 229806 27231 110332246
Monocyte count decreased 20.35 11.94 32 229790 3819 110355658
Back disorder 20.31 11.94 9 229813 20913 110338564
Wrong patient 20.31 11.94 20 229802 1479 110357998
Drug dose omission by device 20.24 11.94 3 229819 14513 110344964
Creatinine renal clearance decreased 20.22 11.94 10 229812 21805 110337672
Rotator cuff syndrome 20.19 11.94 5 229817 16789 110342688
Respiratory syncytial virus infection 20.18 11.94 3 229819 14481 110344996
Sinus rhythm 20.18 11.94 17 229805 1026 110358451
Therapeutic response shortened 20.17 11.94 19 229803 29564 110329913
Glutamate dehydrogenase increased 20.16 11.94 7 229815 64 110359413
Neutrophilia 20.14 11.94 57 229765 10272 110349205
Menstruation irregular 20.05 11.94 40 229782 5757 110353720
Drowning 19.95 11.94 16 229806 901 110358576
Skin lesion 19.90 11.94 49 229773 51582 110307895
Opisthotonus 19.89 11.94 15 229807 771 110358706
Benign ethnic neutropenia 19.87 11.94 8 229814 114 110359363
Liver function test abnormal 19.83 11.94 225 229597 68725 110290752
Pancreatitis acute 19.80 11.94 202 229620 60072 110299405
Angle closure glaucoma 19.79 11.94 30 229792 3469 110356008
Eosinophil count abnormal 19.75 11.94 17 229805 1057 110358420
Right ventricular failure 19.74 11.94 15 229807 25939 110333538
Blepharospasm 19.65 11.94 54 229768 54797 110304680
Differential white blood cell count abnormal 19.64 11.94 24 229798 2260 110357217
Patient elopement 19.55 11.94 11 229811 341 110359136
Excessive masturbation 19.44 11.94 8 229814 121 110359356
Pyrexia 19.42 11.94 1605 228217 896660 109462817
Libido decreased 19.40 11.94 40 229782 5895 110353582
Tooth infection 19.39 11.94 11 229811 22205 110337272
Premature delivery 19.37 11.94 21 229801 30611 110328866
Illness anxiety disorder 19.37 11.94 10 229812 260 110359217
Blood ketone body 19.35 11.94 9 229813 185 110359292
Metastases to lung 19.31 11.94 12 229810 23051 110336426
Mucosal dryness 19.26 11.94 33 229789 4230 110355247
Muscle spasticity 19.19 11.94 28 229794 35887 110323590
Anhedonia 19.13 11.94 73 229749 15355 110344122
Poverty of thought content 19.10 11.94 7 229815 76 110359401
Drop attacks 19.03 11.94 17 229805 1111 110358366
Therapeutic response changed 19.02 11.94 20 229802 1598 110357879
Respiratory dyskinesia 19.01 11.94 7 229815 77 110359400
Injection site mass 19.01 11.94 14 229808 24599 110334878
Upper gastrointestinal haemorrhage 18.95 11.94 48 229774 50048 110309429
Pseudomonas infection 18.86 11.94 18 229804 27835 110331642
Paraphilia 18.85 11.94 7 229815 79 110359398
Blood test abnormal 18.71 11.94 19 229803 28535 110330942
Pharyngeal dystonia 18.68 11.94 6 229816 42 110359435
Blood glucose 18.68 11.94 6 229816 42 110359435
Product storage error 18.62 11.94 11 229811 21717 110337760
Hospitalisation 18.59 11.94 407 229415 142086 110217391
Gastrointestinal necrosis 18.55 11.94 42 229780 6598 110352879
Cold-stimulus headache 18.54 11.94 7 229815 83 110359394
Pneumonia fungal 18.52 11.94 4 229818 14750 110344727
Intracranial pressure increased 18.49 11.94 56 229766 10479 110348998
Blood thrombin increased 18.48 11.94 4 229818 3 110359474
Inferiority complex 18.48 11.94 4 229818 3 110359474
Blood chloride decreased 18.46 11.94 51 229771 9064 110350413
Blood urea decreased 18.45 11.94 29 229793 3461 110356016
Bladder dilatation 18.39 11.94 24 229798 2415 110357062
Postoperative wound infection 18.34 11.94 5 229817 15748 110343729
Nephrogenic diabetes insipidus 18.34 11.94 24 229798 2421 110357056
Rash vesicular 18.33 11.94 4 229818 14648 110344829
Olfactory nerve disorder 18.32 11.94 6 229816 45 110359432
Abscess 18.31 11.94 18 229804 27451 110332026
Tubulointerstitial nephritis 18.31 11.94 55 229767 54229 110305248
End stage renal disease 18.22 11.94 11 229811 21462 110338015
Obesity 18.21 11.94 334 229488 113017 110246460
Acute myeloid leukaemia 18.20 11.94 32 229790 38078 110321399
Bicytopenia 18.20 11.94 42 229780 6682 110352795
Myoglobin blood increased 18.13 11.94 32 229790 4200 110355277
Dyspraxia 18.07 11.94 10 229812 300 110359177
Selective mutism 18.03 11.94 7 229815 90 110359387
Hernia 17.98 11.94 9 229813 19491 110339986
Hyperosmolar state 17.97 11.94 14 229808 756 110358721
Ballismus 17.92 11.94 10 229812 305 110359172
Myocardial infarction 17.85 11.94 286 229536 191797 110167680
Bulimia nervosa 17.77 11.94 10 229812 310 110359167
Tongue biting 17.77 11.94 26 229796 2913 110356564
Specific gravity urine increased 17.76 11.94 12 229810 518 110358959
Disability 17.73 11.94 22 229800 30201 110329276
Visual impairment 17.72 11.94 186 229636 134242 110225235
Skin reaction 17.71 11.94 11 229811 21133 110338344
Infusion site pain 17.70 11.94 7 229815 17412 110342065
Dermatitis 17.70 11.94 19 229803 27818 110331659
Exposure via skin contact 17.70 11.94 3 229819 13144 110346333
Neurodegenerative disorder 17.70 11.94 14 229808 773 110358704
Extensor plantar response 17.56 11.94 21 229801 1934 110357543
Pulmonary alveolar haemorrhage 17.56 11.94 10 229812 20140 110339337
Mixed delusion 17.51 11.94 5 229817 22 110359455
Meige's syndrome 17.48 11.94 4 229818 5 110359472
Musculoskeletal disorder 17.37 11.94 13 229809 22651 110336826
Intellectual disability 17.35 11.94 21 229801 1958 110357519
Electrocardiogram J wave abnormal 17.33 11.94 5 229817 23 110359454
Drug reaction with eosinophilia and systemic symptoms 17.31 11.94 253 229569 81842 110277635
Bilirubin urine present 17.26 11.94 10 229812 328 110359149
Frontotemporal dementia 17.21 11.94 13 229809 670 110358807
White blood cells urine positive 17.16 11.94 44 229778 7480 110351997
Libido disorder 17.15 11.94 10 229812 332 110359145
Freezing phenomenon 17.13 11.94 24 229798 2585 110356892
Gastroenteritis viral 17.02 11.94 24 229798 31202 110328275
Dissociative identity disorder 16.99 11.94 6 229816 58 110359419
Breast cancer 16.97 11.94 34 229788 38508 110320969
Incontinence 16.89 11.94 74 229748 16561 110342916
Skin haemorrhage 16.86 11.94 16 229806 24811 110334666
Chemical poisoning 16.79 11.94 8 229814 174 110359303
Tooth disorder 16.78 11.94 22 229800 29487 110329990
Skin cancer 16.72 11.94 8 229814 17776 110341701
Feelings of worthlessness 16.60 11.94 12 229810 578 110358899
Schizophreniform disorder 16.59 11.94 8 229814 179 110359298
Blood bicarbonate decreased 16.57 11.94 37 229785 5760 110353717
Prostatic specific antigen increased 16.52 11.94 3 229819 12508 110346969
Femur fracture 16.52 11.94 43 229779 44426 110315051
Enthesopathy 16.46 11.94 3 229819 12475 110347002
Device related infection 16.44 11.94 36 229786 39483 110319994
Tricuspid valve sclerosis 16.23 11.94 5 229817 30 110359447
Pre-eclampsia 16.15 11.94 47 229775 8603 110350874
Intention tremor 16.13 11.94 14 229808 880 110358597
Accidental exposure to product by child 16.11 11.94 26 229796 3172 110356305
Distributive shock 16.11 11.94 37 229785 5867 110353610
Carpal tunnel syndrome 16.04 11.94 14 229808 22596 110336881
Gastric ulcer 15.98 11.94 37 229785 39790 110319687
Cystitis haemorrhagic 15.97 11.94 3 229819 12206 110347271
Ileus 15.93 11.94 114 229708 30615 110328862
Gangrene 15.91 11.94 7 229815 16334 110343143
Illiteracy 15.82 11.94 5 229817 33 110359444
Psychogenic visual disorder 15.82 11.94 5 229817 33 110359444
Swollen tongue 15.81 11.94 68 229754 60294 110299183
Fear-related avoidance of activities 15.75 11.94 7 229815 129 110359348
Viral infection 15.74 11.94 57 229765 53082 110306395
Suspected suicide 15.73 11.94 68 229754 15131 110344346
Parkinsonian rest tremor 15.71 11.94 10 229812 390 110359087
Saccadic eye movement 15.71 11.94 8 229814 202 110359275
Blood cholesterol abnormal 15.63 11.94 28 229794 3718 110355759
Rales 15.60 11.94 17 229805 24722 110334755
Inborn error of metabolism 15.54 11.94 3 229819 0 110359477
Psychiatric evaluation abnormal 15.54 11.94 3 229819 0 110359477
Hemiparaesthesia 15.52 11.94 10 229812 398 110359079
Glycosylated haemoglobin increased 15.52 11.94 93 229729 23526 110335951
Oedema peripheral 15.49 11.94 543 229279 328117 110031360
Anticonvulsant drug level increased 15.46 11.94 24 229798 2834 110356643
Secondary tic 15.45 11.94 4 229818 11 110359466
Bone density decreased 15.41 11.94 7 229815 16035 110343442
Traumatic coma 15.40 11.94 6 229816 78 110359399
Tubo-ovarian abscess 15.39 11.94 10 229812 404 110359073
Neglect of personal appearance 15.39 11.94 10 229812 404 110359073
Intervertebral disc protrusion 15.39 11.94 21 229801 27677 110331800
Mean cell haemoglobin decreased 15.39 11.94 41 229781 7133 110352344
Borderline personality disorder 15.37 11.94 15 229807 1097 110358380
Metastases to lymph nodes 15.34 11.94 6 229816 15026 110344451
Pregnancy of partner 15.32 11.94 9 229813 303 110359174
Tangentiality 15.32 11.94 8 229814 213 110359264
Red blood cells urine 15.27 11.94 12 229810 656 110358821
Hyperlipidaemia 15.25 11.94 127 229695 35721 110323756
Progressive supranuclear palsy 15.22 11.94 8 229814 216 110359261
Regressive behaviour 15.19 11.94 8 229814 217 110359260
Increased tendency to bruise 15.14 11.94 3 229819 11755 110347722
Spinal disorder 15.09 11.94 3 229819 11725 110347752
Musculoskeletal discomfort 15.04 11.94 16 229806 23522 110335955
Spinal pain 15.00 11.94 10 229812 18505 110340972
Cellulitis 14.79 11.94 179 229643 125837 110233640
Febrile bone marrow aplasia 14.75 11.94 9 229813 17456 110342021
Mouth ulceration 14.68 11.94 51 229771 48087 110311390
Injection site haemorrhage 14.66 11.94 29 229793 32999 110326478
Pica 14.62 11.94 6 229816 90 110359387
Mood altered 14.59 11.94 85 229737 21290 110338187
Device malfunction 14.58 11.94 19 229803 25539 110333938
Foot fracture 14.57 11.94 19 229803 25527 110333950
Colitis 14.56 11.94 139 229683 102184 110257293
Synovial cyst 14.55 11.94 3 229819 11427 110348050
Compulsive shopping 14.48 11.94 13 229809 855 110358622
Renal cyst 14.48 11.94 10 229812 18162 110341315
Female sexual dysfunction 14.47 11.94 5 229817 45 110359432
Electrocardiogram T wave abnormal 14.47 11.94 29 229793 4188 110355289
Hemiparesis 14.44 11.94 45 229777 43858 110315619
Immune system disorder 14.43 11.94 5 229817 13496 110345981
Intervertebral disc degeneration 14.35 11.94 10 229812 18075 110341402
Floppy iris syndrome 14.27 11.94 9 229813 345 110359132
Colitis microscopic 14.25 11.94 5 229817 13389 110346088
Clonic convulsion 14.24 11.94 17 229805 1563 110357914
Poverty of speech 14.18 11.94 11 229811 590 110358887
Pituitary tumour benign 14.15 11.94 23 229799 2824 110356653
Slow response to stimuli 14.12 11.94 19 229803 1969 110357508
Constricted affect 14.12 11.94 4 229818 17 110359460
Deja vu 14.10 11.94 6 229816 99 110359378
Apnoea 14.10 11.94 61 229761 13578 110345899
Multiple allergies 14.08 11.94 4 229818 12259 110347218
Pneumonia viral 14.05 11.94 3 229819 11154 110348323
Hepatic cancer 14.05 11.94 3 229819 11153 110348324
Conduction disorder 14.05 11.94 28 229794 4027 110355450
Nerve compression 14.02 11.94 3 229819 11134 110348343
Musculoskeletal chest pain 13.98 11.94 24 229798 28823 110330654
Thyroid disorder 13.98 11.94 9 229813 16960 110342517
Paronychia 13.92 11.94 3 229819 11078 110348399
Intestinal infarction 13.91 11.94 16 229806 1414 110358063
Alpha haemolytic streptococcal infection 13.91 11.94 26 229796 3567 110355910
Acute pulmonary oedema 13.90 11.94 71 229751 16925 110342552
Postictal paralysis 13.86 11.94 11 229811 610 110358867
Coagulation factor VIII level decreased 13.83 11.94 5 229817 52 110359425
Pulmonary toxicity 13.83 11.94 10 229812 17736 110341741
Cytopenia 13.75 11.94 26 229796 30090 110329387
Binge eating 13.72 11.94 11 229811 619 110358858
Organic erectile dysfunction 13.68 11.94 6 229816 107 110359370
Pathological fracture 13.67 11.94 4 229818 12028 110347449
Emotional distress 13.65 11.94 148 229674 44699 110314778
Pulse absent 13.65 11.94 53 229769 11239 110348238
Electrocardiogram ST segment elevation 13.62 11.94 46 229776 9114 110350363
Myotonia 13.60 11.94 8 229814 270 110359207
Affective ambivalence 13.59 11.94 4 229818 20 110359457
Rapid eye movement sleep behaviour disorder 13.59 11.94 11 229811 628 110358849
Coprolalia 13.58 11.94 5 229817 55 110359422
High density lipoprotein increased 13.56 11.94 16 229806 1453 110358024
Systolic dysfunction 13.55 11.94 29 229793 4386 110355091
Infusion site erythema 13.55 11.94 4 229818 11955 110347522
Septic shock 13.51 11.94 238 229584 157290 110202187
Ovarian cyst 13.51 11.94 6 229816 13924 110345553
Flatulence 13.50 11.94 59 229763 52090 110307387
Atrioventricular block first degree 13.48 11.94 62 229760 14163 110345314
Gastric atony 13.46 11.94 3 229819 3 110359474
Dependent personality disorder 13.43 11.94 6 229816 112 110359365
Blood creatine phosphokinase decreased 13.35 11.94 15 229807 1292 110358185
Panic disorder 13.34 11.94 25 229797 3436 110356041
Lymphocyte count increased 13.32 11.94 39 229783 7164 110352313
Confabulation 13.31 11.94 10 229812 511 110358966
Social anxiety disorder 13.29 11.94 13 229809 953 110358524
Hepatic function abnormal 13.27 11.94 260 229562 89035 110270442
Alcohol problem 13.27 11.94 5 229817 59 110359418
Cyst 13.25 11.94 9 229813 16487 110342990
Ankylosing spondylitis 13.25 11.94 8 229814 15604 110343873
Laboratory test abnormal 13.24 11.94 47 229775 44032 110315445
Device breakage 13.24 11.94 6 229816 13763 110345714
Drug ineffective for unapproved indication 13.18 11.94 293 229529 102545 110256932
Diverticulum intestinal 13.13 11.94 4 229818 11715 110347762
Neuroleptic-induced deficit syndrome 13.12 11.94 4 229818 23 110359454
Foreign body aspiration 13.08 11.94 10 229812 525 110358952
Pemphigoid 13.04 11.94 13 229809 19694 110339783
Cyanosis 12.99 11.94 106 229716 29635 110329842
Amphetamines positive 12.97 11.94 8 229814 295 110359182
Glucocorticoids increased 12.96 11.94 6 229816 122 110359355
Parkinson's disease 12.96 11.94 16 229806 1523 110357954
Dysphemia 12.95 11.94 27 229795 4010 110355467
Motor dysfunction 12.92 11.94 91 229731 24315 110335162
Haematoma 12.92 11.94 70 229752 58406 110301071
Sudden cardiac death 12.89 11.94 33 229789 5604 110353873
Therapeutic product ineffective 12.89 11.94 21 229801 2583 110356894
Porphyria acute 12.88 11.94 12 229810 18768 110340709
Sputum discoloured 12.87 11.94 24 229798 27921 110331556
Salivary gland calculus 12.80 11.94 8 229814 302 110359175
Neutropenic sepsis 12.80 11.94 28 229794 30718 110328759
Impaired quality of life 12.77 11.94 27 229795 29990 110329487
Anion gap increased 12.72 11.94 28 229794 4316 110355161
Eye irritation 12.69 11.94 32 229790 33420 110326057
Starvation 12.67 11.94 13 229809 1010 110358467
Immediate post-injection reaction 12.66 11.94 9 229813 422 110359055
Decreased gait velocity 12.65 11.94 7 229815 210 110359267
Electrocardiogram ST segment abnormal 12.59 11.94 17 229805 1768 110357709
Hypogonadism 12.58 11.94 18 229804 1976 110357501
Device occlusion 12.58 11.94 8 229814 15177 110344300
Paternal exposure timing unspecified 12.56 11.94 5 229817 69 110359408
Neutrophil percentage increased 12.55 11.94 30 229792 4883 110354594
Product measured potency issue 12.53 11.94 7 229815 214 110359263
Proteinuria 12.48 11.94 42 229780 39976 110319501
Pelvic pain 12.40 11.94 9 229813 15933 110343544
Sideroblastic anaemia 12.33 11.94 9 229813 440 110359037
Cytotoxic oedema 12.33 11.94 9 229813 440 110359037
Spinal compression fracture 12.32 11.94 12 229810 18380 110341097
Ear discomfort 12.32 11.94 4 229818 11245 110348232
Tremor neonatal 12.25 11.94 3 229819 6 110359471
Faeces soft 12.25 11.94 4 229818 11206 110348271
Urine bilirubin decreased 12.17 11.94 6 229816 141 110359336
CSF glucose increased 12.13 11.94 5 229817 76 110359401
Grunting 12.13 11.94 10 229812 586 110358891
Brief psychotic disorder, with postpartum onset 12.10 11.94 4 229818 31 110359446
Left ventricular dysfunction 12.09 11.94 87 229735 23406 110336071
Aortic stenosis 12.08 11.94 6 229816 13053 110346424
General physical condition abnormal 12.08 11.94 39 229783 7551 110351926
Retinal detachment 12.06 11.94 4 229818 11096 110348381
Body temperature decreased 12.04 11.94 38 229784 36897 110322580
Low density lipoprotein increased 12.04 11.94 49 229773 10617 110348860
Legal problem 12.02 11.94 6 229816 145 110359332
Scrotal haematoma 12.01 11.94 5 229817 78 110359399
Cardiac disorder 12.00 11.94 101 229721 76179 110283298
Autoimmune hepatitis 11.99 11.94 8 229814 14796 110344681
Visuospatial deficit 11.99 11.94 4 229818 32 110359445
Paralogism 11.99 11.94 4 229818 32 110359445
Potentiating drug interaction 11.98 11.94 52 229770 11591 110347886

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 35.09 29.20 40 596 1313 112004

Pharmacologic Action:

SourceCodeDescription
ATC N05AH03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
ATC N05AH53 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000932 Antiemetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014150 Antipsychotic Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:65191 second generation antipsychotic
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:35476 antipsychotic agent

Related Drugs by ATC class:

N05AH Diazepines, oxazepines, thiazepines and oxepines 6 drugs
asenapineclotiapineclozapineloxapinequetiapinesamidorphan

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Major depressive disorder indication 370143000
Depression Treatment Adjunct indication
Agitation associated with Bipolar Mania indication
Agitation associated with Schizophrenia indication
Nausea and vomiting off-label use 16932000
Feeling agitated off-label use 24199005
Migraine off-label use 37796009 DOID:6364
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Chemotherapy-induced nausea and vomiting off-label use 236084000
cannabinoid hyperememsis off-label use 11047881000119100
cannabinoid hyperememsis off-label use 11048011000119100
Delirium contraindication 2776000
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Sedation contraindication 72641008
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.72 Basic
pKa3 0.66 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11793805 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA IN A PATIENT WHO HAS PREVIOUSLY EXPERIENCED SIGNIFICANT WEIGHT GAIN INDUCED BY OLANZAPINE ALONE BY ADMINISTERING A COMPOSITION COMPRISING OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 12194035 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11793805 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA IN A PATIENT WHO HAS PREVIOUSLY EXPERIENCED SIGNIFICANT WEIGHT GAIN INDUCED BY OLANZAPINE ALONE BY ADMINISTERING A COMPOSITION COMPRISING OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 12194035 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11793805 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA IN A PATIENT WHO HAS PREVIOUSLY EXPERIENCED SIGNIFICANT WEIGHT GAIN INDUCED BY OLANZAPINE ALONE BY ADMINISTERING A COMPOSITION COMPRISING OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 12194035 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11793805 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA IN A PATIENT WHO HAS PREVIOUSLY EXPERIENCED SIGNIFICANT WEIGHT GAIN INDUCED BY OLANZAPINE ALONE BY ADMINISTERING A COMPOSITION COMPRISING OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 12194035 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 May 31, 2033 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11951111 Nov. 12, 2041 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING A BILAYER TABLET COMPRISING OLANZAPINE AND SAMIDORPHAN

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.52 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.32 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 7.68 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 8.05 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(1A) dopamine receptor GPCR Ki 7.40 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.49 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.74 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 6.26 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Kd 5.90 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 7.92 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.98 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.72 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.09 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.10 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.16 WOMBAT-PK
Histamine H2 receptor GPCR Ki 7.36 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.51 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 6.12 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.54 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 7.59 DRUG MATRIX
5-hydroxytryptamine receptor 3A Ion channel Ki 6.70 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.92 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.70 IUPHAR
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 6.43 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.10 WOMBAT-PK
Histone H1.0 Nuclear other Ki 8.70 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 7.14 WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 5.56 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.68 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.36 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.19 CHEMBL
Histamine H1 receptor GPCR Ki 8.20 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.66 CHEMBL
D(2) dopamine receptor GPCR Ki 7.90 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.40 CHEMBL
Transporter Transporter Ki 6.02 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 9.52 CHEMBL
D(3) dopamine receptor GPCR Ki 7.41 CHEMBL
D(4) dopamine receptor GPCR Ki 7.30 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.60 IUPHAR
Transporter Transporter Ki 5.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.54 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.92 CHEMBL

External reference:

IDSource
4020996 VUID
N0000148465 NUI
D00454 KEGG_DRUG
221373-18-8 SECONDARY_CAS_RN
4020996 VANDF
C0171023 UMLSCUI
CHEBI:7735 CHEBI
CHEMBL715 ChEMBL_ID
CHEMBL3989694 ChEMBL_ID
DB00334 DRUGBANK_ID
D000077152 MESH_DESCRIPTOR_UI
135398745 PUBCHEM_CID
47 IUPHAR_LIGAND_ID
6956 INN_ID
N7U69T4SZR UNII
1294588 RXNORM
169390 MMSL
172501 MMSL
39248 MMSL
5198 MMSL
6063 MMSL
d04050 MMSL
006204 NDDF
013309 NDDF
108441004 SNOMEDCT_US
386849001 SNOMEDCT_US
725800004 SNOMEDCT_US
N7U69T4SZR INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5245 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5246 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5247 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5248 TABLET, ORALLY DISINTEGRATING 20 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 3 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 6 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 6 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 12 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 12 mg ORAL ANDA 31 sections
OlanzapineIntramuscular HUMAN PRESCRIPTION DRUG LABEL 1 0121-1072 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 34 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9199 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 33 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0517-0955 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0527-3161 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 35 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0527-3162 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 35 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0527-3163 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 35 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0527-3164 TABLET, ORALLY DISINTEGRATING 20 mg ORAL ANDA 35 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8243 TABLET, FILM COATED 2.50 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8244 TABLET, FILM COATED 5 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8245 TABLET, FILM COATED 10 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8246 TABLET, FILM COATED 20 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8566 TABLET, FILM COATED 15 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0781-3159 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 29 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0781-9105 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6078 TABLET 2.50 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6079 TABLET 5 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6080 TABLET 7.50 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6081 TABLET 10 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6082 TABLET 15 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6083 TABLET 20 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0904-6286 TABLET, FILM COATED 15 mg ORAL ANDA 31 sections