olanzapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1982 132539-06-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • olanzapine pamoate
  • olanzapine embonate
  • zyprexa relprevv
  • olanzapine pamoate monohydrate
  • olanzapine
  • zyprexa
  • LY 170053
  • LY-170053
The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown.
  • Molecular weight: 312.44
  • Formula: C17H20N4S
  • CLOGP: 2.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.52
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1996 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1445.70 11.35 593 89251 10537 50504743
Suicide attempt 1048.04 11.35 810 89034 50922 50464358
Sedation 892.14 11.35 598 89246 30012 50485268
Intentional overdose 889.95 11.35 798 89046 61706 50453574
Intentional self-injury 664.86 11.35 448 89396 22664 50492616
Sopor 658.76 11.35 421 89423 19458 50495822
Extrapyramidal disorder 641.05 11.35 344 89500 11426 50503854
Akathisia 636.86 11.35 305 89539 7924 50507356
Dystonia 611.79 11.35 335 89509 11591 50503689
Electrocardiogram QT prolonged 599.16 11.35 590 89254 51296 50463984
Blood prolactin abnormal 581.70 11.35 197 89647 1978 50513302
Sexual dysfunction 577.03 11.35 218 89626 3074 50512206
Overdose 529.10 11.35 762 89082 98965 50416315
Agitation 520.11 11.35 554 89290 52830 50462450
Anosognosia 510.86 11.35 180 89664 2054 50513226
Drug interaction 505.69 11.35 1102 88742 198519 50316761
Psychotic disorder 486.44 11.35 362 89482 21450 50493830
Toxicity to various agents 475.78 11.35 1117 88727 211382 50303898
Disturbance in social behaviour 465.44 11.35 180 89664 2714 50512566
Metabolic disorder 458.52 11.35 212 89632 5074 50510206
Arthralgia 452.15 11.35 112 89732 438590 50076690
Hyperprolactinaemia 439.13 11.35 180 89664 3185 50512095
Schizophrenia 436.16 11.35 228 89616 7169 50508111
Delusion 424.24 11.35 253 89591 10316 50504964
Drug abuse 406.63 11.35 516 89328 59330 50455950
Somnolence 402.86 11.35 865 88979 154120 50361160
Dyskinesia 402.56 11.35 359 89485 27502 50487778
Weight increased 398.17 11.35 1011 88833 200880 50314400
Pain 397.40 11.35 272 89572 578631 49936649
Post-injection delirium sedation syndrome 396.86 11.35 78 89766 22 50515258
Hallucination, auditory 395.05 11.35 243 89601 10485 50504795
Parkinsonism 376.64 11.35 220 89624 8627 50506653
Catatonia 359.25 11.35 161 89683 3575 50511705
Completed suicide 356.37 11.35 748 89096 131141 50384139
Diabetes mellitus 349.35 11.35 433 89411 48600 50466680
Personality change 347.17 11.35 179 89665 5466 50509814
Mania 336.50 11.35 221 89623 10695 50504585
Tardive dyskinesia 320.44 11.35 185 89659 7094 50508186
Coma 319.61 11.35 447 89397 56432 50458848
Rheumatoid arthritis 307.48 11.35 12 89832 202538 50312742
Pleurothotonus 301.96 11.35 106 89738 1195 50514085
Aggression 281.29 11.35 260 89584 20856 50494424
Suicidal ideation 264.32 11.35 403 89441 54982 50460298
Metabolic syndrome 260.92 11.35 96 89748 1251 50514029
Depressed level of consciousness 260.70 11.35 387 89457 51566 50463714
Fatigue 258.14 11.35 546 89298 707055 49808225
Salivary hypersecretion 257.29 11.35 155 89689 6436 50508844
Hypothermia 253.57 11.35 193 89651 11823 50503457
Muscle rigidity 250.66 11.35 177 89667 9652 50505628
Psychomotor hyperactivity 233.74 11.35 166 89678 9135 50506145
Arthropathy 230.93 11.35 12 89832 157894 50357386
Restlessness 230.53 11.35 253 89591 24920 50490360
Hypomania 229.47 11.35 126 89718 4379 50510901
Joint swelling 229.28 11.35 75 89769 245211 50270069
Abdominal discomfort 227.01 11.35 65 89779 231576 50283704
Tachycardia 225.43 11.35 527 89317 99236 50416044
Blood prolactin increased 225.05 11.35 110 89734 2989 50512291
Headache 222.61 11.35 348 89496 506187 50009093
Schizoaffective disorder 218.29 11.35 97 89747 2109 50513171
Infusion related reaction 211.78 11.35 26 89818 169531 50345749
Delirium 211.27 11.35 298 89546 37894 50477386
Rash 206.31 11.35 286 89558 437185 50078095
Sinusitis 203.87 11.35 30 89814 170528 50344752
Hallucination 203.80 11.35 326 89518 46331 50468949
Diarrhoea 202.80 11.35 468 89376 588008 49927272
Hypersensitivity 200.67 11.35 66 89778 215095 50300185
Dyspnoea 199.73 11.35 422 89422 547186 49968094
Swelling 197.46 11.35 56 89788 200816 50314464
Alopecia 196.15 11.35 95 89749 244952 50270328
Treatment noncompliance 195.26 11.35 254 89590 29896 50485384
Contraindicated product administered 190.59 11.35 21 89823 148937 50366343
Drug hypersensitivity 185.20 11.35 108 89736 250902 50264378
Gestational diabetes 184.74 11.35 132 89712 7333 50507947
Abnormal behaviour 184.22 11.35 200 89644 19458 50495822
Pruritus 183.73 11.35 141 89703 283427 50231853
Persecutory delusion 177.16 11.35 86 89758 2301 50512979
Miosis 175.83 11.35 120 89724 6190 50509090
Peripheral swelling 175.48 11.35 73 89771 205863 50309417
Confusional state 161.61 11.35 706 89138 185222 50330058
Oculogyric crisis 161.11 11.35 69 89775 1368 50513912
Nasopharyngitis 160.20 11.35 71 89773 192856 50322424
Glossodynia 159.32 11.35 12 89832 115557 50399723
Social avoidant behaviour 158.57 11.35 84 89760 2713 50512567
Drug intolerance 156.37 11.35 98 89746 219006 50296274
Pain in extremity 155.72 11.35 153 89691 272712 50242568
Systemic lupus erythematosus 154.26 11.35 31 89813 140591 50374689
Back pain 149.47 11.35 104 89740 219926 50295354
Paranoia 146.75 11.35 132 89712 10216 50505064
Camptocormia 146.22 11.35 43 89801 258 50515022
Blood glucose increased 144.13 11.35 361 89483 70963 50444317
Tremor 143.84 11.35 490 89354 114413 50400867
Galactorrhoea 138.74 11.35 85 89759 3638 50511642
Injection site pain 136.21 11.35 18 89826 111006 50404274
Blood creatine phosphokinase increased 135.93 11.35 199 89645 26168 50489112
Psychiatric decompensation 133.15 11.35 58 89786 1200 50514080
Prescribed overdose 127.21 11.35 143 89701 14457 50500823
Dysarthria 126.04 11.35 233 89611 37170 50478110
Drug level increased 125.79 11.35 163 89681 19105 50496175
Antipsychotic drug level increased 123.63 11.35 74 89770 3035 50512245
Exposure during pregnancy 122.71 11.35 482 89362 120533 50394747
Orthostatic hypertension 120.11 11.35 39 89805 339 50514941
Bradyphrenia 119.30 11.35 94 89750 6058 50509222
Cough 117.22 11.35 154 89690 241110 50274170
Psychotic symptom 115.78 11.35 52 89792 1160 50514120
Pneumonia aspiration 113.20 11.35 200 89644 30804 50484476
Urticaria 111.80 11.35 45 89799 129516 50385764
Blood triglycerides increased 111.09 11.35 118 89726 11194 50504086
Rhabdomyolysis 107.08 11.35 223 89621 38804 50476476
Neutropenia 105.09 11.35 530 89314 147435 50367845
Discomfort 104.97 11.35 31 89813 108349 50406931
Posture abnormal 102.47 11.35 57 89787 2032 50513248
Nausea 101.92 11.35 785 89059 704613 49810667
Disorientation 101.18 11.35 206 89638 35278 50480002
Antipsychotic drug level above therapeutic 100.80 11.35 44 89800 915 50514365
Therapeutic product effect decreased 99.57 11.35 59 89785 135991 50379289
Anxiety 98.57 11.35 595 89249 177011 50338269
Cardio-respiratory arrest 97.76 11.35 262 89582 53630 50461650
Treatment failure 97.51 11.35 62 89782 137575 50377705
Arthritis 97.43 11.35 18 89826 86703 50428577
Jaundice cholestatic 96.76 11.35 77 89767 5034 50510246
Leukopenia 96.16 11.35 301 89543 67227 50448053
Obesity 95.87 11.35 133 89711 16642 50498638
Granulocytopenia 95.18 11.35 77 89767 5154 50510126
Diabetic coma 93.27 11.35 38 89806 661 50514619
Pulmonary embolism 92.68 11.35 392 89452 101312 50413968
Amenorrhoea 91.39 11.35 93 89751 8391 50506889
Chest discomfort 90.74 11.35 26 89818 92696 50422584
Psychomotor retardation 90.51 11.35 63 89781 3355 50511925
Injection site erythema 89.89 11.35 13 89831 74923 50440357
Psychiatric symptom 88.98 11.35 70 89774 4500 50510780
Product dose omission issue 88.58 11.35 118 89726 183720 50331560
Mental disorder 87.00 11.35 147 89697 21844 50493436
Obsessive-compulsive disorder 84.81 11.35 60 89784 3280 50512000
Apathy 83.61 11.35 84 89760 7464 50507816
Generalised tonic-clonic seizure 82.55 11.35 159 89685 26151 50489129
Insurance issue 81.97 11.35 53 89791 2495 50512785
Pericarditis 80.91 11.35 20 89824 78669 50436611
Bipolar disorder 80.05 11.35 78 89766 6679 50508601
Seizure 79.32 11.35 416 89428 117458 50397822
Respiratory depression 77.45 11.35 101 89743 11909 50503371
Impaired healing 77.29 11.35 15 89829 69771 50445509
Type 2 diabetes mellitus 76.88 11.35 181 89663 34194 50481086
Mutism 74.14 11.35 40 89804 1341 50513939
Mental impairment 74.14 11.35 99 89745 11945 50503335
Infection 73.57 11.35 121 89723 172833 50342447
Increased appetite 73.02 11.35 82 89762 8279 50507001
Polydipsia 72.19 11.35 53 89791 3071 50512209
Osteoarthritis 71.39 11.35 17 89827 68589 50446691
Stomatitis 71.29 11.35 46 89798 101298 50413982
Myocarditis 71.22 11.35 79 89765 7868 50507412
Wound 69.15 11.35 52 89792 105742 50409538
Product use issue 68.91 11.35 99 89745 149376 50365904
Loss of consciousness 68.63 11.35 366 89478 103987 50411293
Hallucinations, mixed 67.57 11.35 57 89787 4046 50511234
Serotonin syndrome 67.53 11.35 141 89703 24572 50490708
Thinking abnormal 67.28 11.35 84 89760 9483 50505797
Dyslipidaemia 66.99 11.35 67 89777 5921 50509359
Negativism 66.64 11.35 25 89819 345 50514935
Myalgia 65.97 11.35 74 89770 124245 50391035
Blister 65.41 11.35 35 89809 85383 50429897
Obsessive-compulsive symptom 65.37 11.35 15 89829 25 50515255
Respiratory arrest 64.93 11.35 156 89688 29853 50485427
Cogwheel rigidity 62.23 11.35 39 89805 1738 50513542
Sinus tachycardia 62.09 11.35 125 89719 21229 50494051
Hyponatraemia 61.73 11.35 335 89509 95804 50419476
Poisoning 61.45 11.35 92 89752 12337 50502943
Lower respiratory tract infection 60.68 11.35 48 89796 95153 50420127
Irritability 59.61 11.35 146 89698 28280 50487000
Injection site pruritus 59.25 11.35 3 89841 40408 50474872
Obsessive thoughts 58.91 11.35 25 89819 484 50514796
Screaming 58.81 11.35 46 89798 2932 50512348
Hyperglycaemia 58.13 11.35 169 89675 36236 50479044
Altered state of consciousness 57.54 11.35 123 89721 21787 50493493
Speech disorder 56.74 11.35 165 89679 35383 50479897
Cardiac arrest 56.09 11.35 295 89549 83356 50431924
Wheezing 56.08 11.35 20 89824 62027 50453253
Herpes zoster 55.69 11.35 28 89816 70758 50444522
Gastrointestinal disorder 54.88 11.35 52 89792 94404 50420876
Influenza 54.76 11.35 47 89797 89491 50425789
Psoriatic arthropathy 54.48 11.35 9 89835 47023 50468257
Mydriasis 54.46 11.35 80 89764 10547 50504733
Acute psychosis 54.34 11.35 39 89805 2181 50513099
Unresponsive to stimuli 53.67 11.35 147 89697 30462 50484818
Substance abuse 53.39 11.35 50 89794 4074 50511206
Irritable bowel syndrome 53.02 11.35 13 89831 51428 50463852
Malaise 52.70 11.35 364 89480 335168 50180112
Mobility decreased 52.62 11.35 39 89805 79909 50435371
Bone pain 52.62 11.35 10 89834 47219 50468061
Torsade de pointes 52.06 11.35 83 89761 11752 50503528
Disturbance in attention 51.95 11.35 147 89697 31039 50484241
Abdominal pain upper 51.91 11.35 130 89714 159179 50356101
Hyperthermia 51.62 11.35 66 89778 7630 50507650
Folliculitis 51.49 11.35 5 89839 39220 50476060
Anaphylactic reaction 51.34 11.35 16 89828 54039 50461241
Trimethylaminuria 51.11 11.35 16 89828 122 50515158
Somatic symptom disorder of pregnancy 51.01 11.35 15 89829 90 50515190
Hyperammonaemic encephalopathy 50.96 11.35 36 89808 1963 50513317
Muscle injury 50.70 11.35 4 89840 37107 50478173
Hypoaesthesia 50.48 11.35 93 89751 127164 50388116
Neutrophil count decreased 50.42 11.35 188 89656 45838 50469442
Intentional product use issue 50.01 11.35 38 89806 76880 50438400
Impulse-control disorder 49.30 11.35 24 89820 646 50514634
White blood cell count increased 49.19 11.35 176 89668 42064 50473216
Injection site reaction 48.99 11.35 14 89830 50018 50465262
Depression 48.71 11.35 478 89366 164945 50350335
Chest pain 48.33 11.35 157 89687 176725 50338555
Logorrhoea 48.30 11.35 37 89807 2287 50512993
Polyuria 47.66 11.35 61 89783 7060 50508220
Urinary retention 47.14 11.35 127 89717 26063 50489217
Self esteem decreased 46.79 11.35 22 89822 547 50514733
Diet refusal 46.50 11.35 22 89822 555 50514725
Food craving 46.46 11.35 30 89814 1409 50513871
Hepatocellular injury 45.88 11.35 125 89719 25822 50489458
Drooling 45.69 11.35 42 89802 3342 50511938
Neuropathy peripheral 45.65 11.35 63 89781 96694 50418586
White blood cell count decreased 45.63 11.35 359 89485 116363 50398917
Stupor 45.54 11.35 43 89801 3540 50511740
Hypertonia 45.45 11.35 45 89799 3928 50511352
Osteoporosis 44.99 11.35 12 89832 44867 50470413
Hyperphagia 44.74 11.35 30 89814 1502 50513778
Euphoric mood 44.68 11.35 45 89799 4010 50511270
Neck pain 44.25 11.35 23 89821 57044 50458236
Sleep disorder due to general medical condition, insomnia type 44.08 11.35 3 89841 31444 50483836
Musculoskeletal pain 44.00 11.35 38 89806 72139 50443141
Coma scale abnormal 43.74 11.35 48 89796 4723 50510557
Flushing 43.70 11.35 33 89811 66982 50448298
Psoriasis 43.70 11.35 35 89809 68965 50446315
Sudden death 43.66 11.35 66 89778 8925 50506355
Knee arthroplasty 43.49 11.35 6 89838 35840 50479440
Brain stem thrombosis 42.68 11.35 8 89836 0 50515280
Asthma 42.32 11.35 58 89786 89279 50426001
Homicide 42.16 11.35 18 89826 354 50514926
Muscle spasms 42.03 11.35 101 89743 125452 50389828
Megacolon 41.82 11.35 30 89814 1676 50513604
Refusal of treatment by patient 41.49 11.35 48 89796 5005 50510275
Electroencephalogram abnormal 40.71 11.35 40 89804 3459 50511821
Inappropriate antidiuretic hormone secretion 40.70 11.35 79 89765 13064 50502216
Nasal congestion 40.54 11.35 20 89824 51100 50464180
Alanine aminotransferase increased 40.35 11.35 282 89562 88077 50427203
Injection site swelling 40.33 11.35 12 89832 41761 50473519
Bradykinesia 40.26 11.35 42 89802 3901 50511379
Bipolar I disorder 40.24 11.35 28 89816 1490 50513790
Device expulsion 39.67 11.35 3 89841 28819 50486461
Contusion 39.36 11.35 88 89756 112095 50403185
Symptom recurrence 39.23 11.35 21 89823 693 50514587
Self-injurious ideation 38.85 11.35 32 89812 2197 50513083
Musculoskeletal stiffness 38.69 11.35 109 89735 128372 50386908
Cognitive disorder 38.56 11.35 168 89676 43955 50471325
Inflammation 38.44 11.35 27 89817 56885 50458395
Osteonecrosis of jaw 38.18 11.35 6 89838 32520 50482760
Delusion of reference 38.16 11.35 12 89832 93 50515187
Depressive symptom 38.02 11.35 37 89807 3163 50512117
Erythema 37.91 11.35 133 89711 146281 50368999
Maternal exposure during pregnancy 37.56 11.35 151 89693 159627 50355653
Cor pulmonale acute 37.50 11.35 16 89828 314 50514966
Hypernatraemia 37.44 11.35 51 89793 6270 50509010
Embolism venous 37.36 11.35 33 89811 2492 50512788
Hypokinesia 37.30 11.35 73 89771 12144 50503136
Epilepsy 37.24 11.35 103 89741 21464 50493816
Intentional product misuse 37.14 11.35 173 89671 46561 50468719
Fibromyalgia 36.58 11.35 17 89827 44961 50470319
Impulsive behaviour 36.57 11.35 26 89818 1432 50513848
Neutrophil count increased 36.48 11.35 79 89765 14116 50501164
Oropharyngeal pain 36.36 11.35 51 89793 77750 50437530
Plasma cell mastitis 36.10 11.35 9 89835 25 50515255
Illusion 36 11.35 22 89822 937 50514343
Electrocardiogram T wave inversion 35.58 11.35 36 89808 3225 50512055
Dyspnoea exertional 35.01 11.35 24 89820 51209 50464071
Gamma-glutamyltransferase increased 34.98 11.35 124 89720 29499 50485781
Hip arthroplasty 34.85 11.35 6 89838 30423 50484857
Depressed mood 34.81 11.35 136 89708 33887 50481393
Agranulocytosis 34.73 11.35 100 89744 21321 50493959
Poisoning deliberate 34.13 11.35 55 89789 7857 50507423
Head banging 33.99 11.35 16 89828 399 50514881
Myoclonic epilepsy 33.15 11.35 21 89823 954 50514326
Behaviour disorder 33.03 11.35 30 89814 2350 50512930
Disease progression 32.98 11.35 76 89768 95790 50419490
Blunted affect 32.51 11.35 13 89831 215 50515065
Diabetic ketoacidosis 32.50 11.35 87 89757 17785 50497495
Menstruation irregular 32.46 11.35 47 89797 6115 50509165
Waxy flexibility 32.42 11.35 11 89833 111 50515169
Interstitial lung disease 32.40 11.35 28 89816 53148 50462132
Multiple sclerosis relapse 32.31 11.35 18 89826 42946 50472334
Dyspepsia 32.26 11.35 51 89793 74046 50441234
Flat affect 32.11 11.35 23 89821 1282 50513998
Refusal of examination 32.09 11.35 10 89834 75 50515205
Abdominal pain 31.96 11.35 267 89577 235961 50279319
Chills 31.40 11.35 79 89765 96608 50418672
Ataxia 31.26 11.35 73 89771 13713 50501567
Distractibility 31.22 11.35 15 89829 392 50514888
Circulatory collapse 31.11 11.35 92 89752 19908 50495372
Asthenia 31.05 11.35 390 89454 318652 50196628
Respiratory dyskinesia 30.70 11.35 8 89836 28 50515252
Personality change due to a general medical condition 30.39 11.35 10 89834 91 50515189
Feeling guilty 30.28 11.35 16 89828 514 50514766
Oromandibular dystonia 30.11 11.35 15 89829 425 50514855
Mental status changes 30.10 11.35 136 89708 36136 50479144
Upper respiratory tract infection 30.00 11.35 44 89800 65854 50449426
Paraesthesia 29.94 11.35 111 89733 120132 50395148
Hot flush 29.77 11.35 21 89823 44148 50471132
Suicidal behaviour 29.64 11.35 28 89816 2306 50512974
Grandiosity 29.62 11.35 13 89831 274 50515006
Diabetic hyperosmolar coma 29.52 11.35 14 89830 355 50514925
Affective disorder 29.48 11.35 41 89803 5140 50510140
Disinhibition 28.93 11.35 18 89826 792 50514488
Psychotic disorder due to a general medical condition 28.78 11.35 12 89832 222 50515058
Coma scale 28.76 11.35 8 89836 38 50515242
Feeling hot 28.65 11.35 17 89827 39185 50476095
Throat irritation 28.62 11.35 9 89835 30230 50485050
Monocyte count decreased 28.61 11.35 25 89819 1861 50513419
Abnormal clotting factor 28.54 11.35 10 89834 112 50515168
Basal cell carcinoma 28.12 11.35 4 89840 23352 50491928
Myoclonus 27.90 11.35 72 89772 14398 50500882
Pharyngeal dystonia 27.87 11.35 6 89838 6 50515274
Device dislocation 27.62 11.35 3 89841 21543 50493737
Influenza like illness 27.51 11.35 37 89807 57422 50457858
Ill-defined disorder 27.40 11.35 34 89810 54620 50460660
Sciatica 27.35 11.35 3 89841 21379 50493901
Weight decreased 27.30 11.35 256 89588 220989 50294291
Migraine 27.27 11.35 58 89786 75222 50440058
Blood bilirubin increased 27.24 11.35 121 89723 31917 50483363
Leukocytosis 26.22 11.35 94 89750 22485 50492795
Thought blocking 26.16 11.35 9 89835 95 50515185
Cardiac failure congestive 25.83 11.35 71 89773 84311 50430969
Negative symptoms in schizophrenia 25.59 11.35 9 89835 102 50515178
Limb discomfort 25.40 11.35 6 89838 24351 50490929
Loss of personal independence in daily activities 25.35 11.35 54 89790 69996 50445284
Water intoxication 25.32 11.35 13 89831 393 50514887
Bundle branch block right 25.30 11.35 36 89808 4609 50510671
Burning sensation 25.26 11.35 26 89818 45420 50469860
Selective eating disorder 25.24 11.35 23 89821 1809 50513471
Cataract 25.24 11.35 28 89816 47272 50468008
Device issue 25.06 11.35 3 89841 19969 50495311
Akinesia 25.04 11.35 21 89823 1478 50513802
Accidental overdose 25.01 11.35 84 89760 19449 50495831
Apallic syndrome 25.00 11.35 15 89829 618 50514662
Rhinorrhoea 24.92 11.35 33 89811 51550 50463730
Injection site haemorrhage 24.91 11.35 4 89840 21342 50493938
Skin ulcer 24.86 11.35 16 89828 35302 50479978
Eosinophil count increased 24.85 11.35 51 89793 8779 50506501
Brain injury 24.85 11.35 41 89803 5973 50509307
Sinus rhythm 24.84 11.35 15 89829 625 50514655
Diverticulitis 24.81 11.35 14 89830 33168 50482112
Psychomotor skills impaired 24.77 11.35 24 89820 2040 50513240
Acquired haemophilia 24.75 11.35 17 89827 886 50514394
Phagophobia 24.71 11.35 7 89837 36 50515244
Abulia 24.70 11.35 13 89831 414 50514866
Withdrawal syndrome 24.64 11.35 78 89766 17512 50497768
Hallucination, visual 24.59 11.35 75 89769 16507 50498773
Eosinophilia 24.58 11.35 81 89763 18571 50496709
Impaired self-care 24.16 11.35 22 89822 1729 50513551
Muscular weakness 24.12 11.35 87 89757 94926 50420354
Bronchitis 24.11 11.35 99 89745 104060 50411220
Anaemia 24.02 11.35 310 89534 252146 50263134
Breast enlargement 24.01 11.35 20 89824 1395 50513885
Atrial fibrillation 23.99 11.35 96 89748 101649 50413631
Skin exfoliation 23.97 11.35 15 89829 33597 50481683
Lethargy 23.88 11.35 160 89684 49272 50466008
Aspartate aminotransferase increased 23.71 11.35 227 89617 77771 50437509
Pain in jaw 23.70 11.35 20 89824 38408 50476872
Tachypnoea 23.58 11.35 68 89776 14509 50500771
Neuralgia 23.58 11.35 5 89839 21858 50493422
Abnormal weight gain 23.56 11.35 20 89824 1432 50513848
Wrong drug 23.55 11.35 9 89835 131 50515149
Drug ineffective 23.50 11.35 1203 88641 818130 49697150
COVID-19 23.42 11.35 29 89815 46633 50468647
Urinary tract infection 23.23 11.35 270 89574 223750 50291530
Pancreatitis 23.09 11.35 142 89702 42472 50472808
Bone disorder 23.08 11.35 3 89841 18749 50496531
Anaphylactic shock 23.02 11.35 4 89840 20151 50495129
Electrocardiogram J wave 22.75 11.35 5 89839 6 50515274
Dissociative disorder 22.60 11.35 10 89834 215 50515065
Patient dissatisfaction with treatment 22.52 11.35 7 89837 52 50515228
Ketoacidosis 22.43 11.35 31 89813 3864 50511416
Ear infection 22.41 11.35 9 89835 25961 50489319
Meige's syndrome 22.31 11.35 5 89839 7 50515273
Breast discomfort 22.28 11.35 12 89832 401 50514879
Neoplasm progression 22.23 11.35 12 89832 29145 50486135
Major depression 22.07 11.35 42 89802 6842 50508438
Antiphospholipid antibodies 22.07 11.35 9 89835 157 50515123
Bursitis 22.03 11.35 6 89838 22129 50493151
Electrocardiogram J wave abnormal 21.91 11.35 5 89839 8 50515272
Ideas of reference 21.90 11.35 8 89836 102 50515178
Autonomic nervous system imbalance 21.87 11.35 24 89820 2361 50512919
Polydipsia psychogenic 21.75 11.35 7 89837 59 50515221
Rash pruritic 21.72 11.35 32 89812 47814 50467466
Unevaluable event 21.71 11.35 30 89814 46036 50469244
Insulin C-peptide increased 21.64 11.35 7 89837 60 50515220
Pressure of speech 21.54 11.35 13 89831 541 50514739
Ileus paralytic 21.49 11.35 31 89813 4019 50511261
Constricted affect 21.34 11.35 4 89840 0 50515280
Night sweats 21.29 11.35 17 89827 33557 50481723
Haemoglobin urine 21.22 11.35 8 89836 112 50515168
Differential white blood cell count abnormal 21.17 11.35 14 89830 685 50514595
Palpitations 21.14 11.35 91 89753 94415 50420865
Pleural effusion 21.06 11.35 74 89770 81380 50433900
Retinal coloboma 21.00 11.35 6 89838 32 50515248
Haematochezia 20.85 11.35 24 89820 39858 50475422
Pulmonary mass 20.75 11.35 4 89840 18701 50496579
Bezoar 20.71 11.35 18 89826 1330 50513950
Hypotonia 20.59 11.35 45 89799 8089 50507191
Ventricular dyskinesia 20.48 11.35 8 89836 124 50515156
Hyperthermia malignant 20.46 11.35 14 89830 725 50514555
Joint range of motion decreased 20.45 11.35 4 89840 18508 50496772
Productive cough 20.45 11.35 39 89805 52655 50462625
Hepatitis toxic 20.24 11.35 25 89819 2791 50512489
Drug monitoring procedure incorrectly performed 20.19 11.35 8 89836 129 50515151
Femur fracture 20.18 11.35 22 89822 37442 50477838
Throat tightness 20.10 11.35 6 89838 20841 50494439
Compulsions 19.95 11.35 9 89835 203 50515077
Hypoxic-ischaemic encephalopathy 19.80 11.35 29 89815 3813 50511467
Psychogenic visual disorder 19.77 11.35 5 89839 15 50515265
Encephalitis autoimmune 19.74 11.35 17 89827 1241 50514039
Iris coloboma 19.74 11.35 6 89838 41 50515239
Insomnia 19.64 11.35 427 89417 174438 50340842
Cytomegalovirus infection 19.59 11.35 4 89840 17958 50497322
Somnambulism 19.58 11.35 33 89811 4891 50510389
Gastrointestinal sounds abnormal 19.55 11.35 28 89816 3606 50511674
Hyporesponsive to stimuli 19.44 11.35 15 89829 937 50514343
Hypoventilation 19.35 11.35 29 89815 3892 50511388
Respiratory tract infection 19.33 11.35 17 89827 32000 50483280
Staring 19.33 11.35 18 89826 1456 50513824
Hallucination, olfactory 19.32 11.35 9 89835 219 50515061
Long QT syndrome 19.20 11.35 25 89819 2942 50512338
Electrocardiogram abnormal 19.17 11.35 42 89802 7563 50507717
Feelings of worthlessness 19.07 11.35 10 89834 316 50514964
Mucosal inflammation 19.06 11.35 26 89818 40116 50475164
Skin discolouration 19.06 11.35 18 89826 32739 50482541
Stress 19.02 11.35 42 89802 53751 50461529
Tubo-ovarian abscess 19.02 11.35 10 89834 318 50514962
Cholelithiasis 19.00 11.35 124 89720 37849 50477431
Product packaging confusion 18.99 11.35 8 89836 152 50515128
Caesarean section 18.92 11.35 66 89778 15573 50499707
Hepatotoxicity 18.91 11.35 97 89747 27129 50488151
Suspiciousness 18.90 11.35 10 89834 322 50514958
Maternal exposure during breast feeding 18.89 11.35 26 89818 3228 50512052
Parkinsonian gait 18.83 11.35 11 89833 431 50514849
Hypotonia neonatal 18.83 11.35 15 89829 982 50514298
Kidney infection 18.81 11.35 5 89839 18741 50496539
Localised infection 18.70 11.35 11 89833 25474 50489806
Blood pressure increased 18.65 11.35 149 89695 132983 50382297
Insulin resistance 18.63 11.35 13 89831 695 50514585
Thrombosis 18.60 11.35 45 89799 55788 50459492
Condition aggravated 18.59 11.35 673 89171 296385 50218895
Personality disorder 18.57 11.35 30 89814 4294 50510986
Asphyxia 18.51 11.35 34 89810 5393 50509887
Central obesity 18.50 11.35 15 89829 1007 50514273
Hepatic cytolysis 18.47 11.35 43 89801 8060 50507220
Rebound psychosis 18.47 11.35 5 89839 21 50515259
Overweight 18.43 11.35 25 89819 3061 50512219
Joint stiffness 18.41 11.35 16 89828 30292 50484988
Hypercapnia 18.39 11.35 31 89813 4596 50510684
Fluid retention 18.36 11.35 39 89805 50610 50464670
Surgery 18.28 11.35 16 89828 30189 50485091
Genitourinary symptom 18.10 11.35 6 89838 56 50515224
Nephrolithiasis 18.01 11.35 21 89823 34672 50480608
Death 18.00 11.35 440 89404 324939 50190341
Nuchal rigidity 17.96 11.35 12 89832 597 50514683
Echolalia 17.96 11.35 8 89836 175 50515105
Disease recurrence 17.95 11.35 77 89767 20004 50495276
Eosinophil count decreased 17.94 11.35 18 89826 1597 50513683
Taciturnity 17.69 11.35 4 89840 6 50515274
Dysphoria 17.68 11.35 31 89813 4743 50510537
Neonatal respiratory depression 17.64 11.35 6 89838 61 50515219
Delusional disorder, unspecified type 17.61 11.35 10 89834 371 50514909
Stereotypy 17.59 11.35 10 89834 372 50514908
Suspected suicide 17.57 11.35 33 89811 5324 50509956
Self-medication 17.48 11.35 21 89823 2278 50513002
Gastric disorder 17.47 11.35 16 89828 29532 50485748
Myocardial reperfusion injury 17.44 11.35 5 89839 27 50515253
Delusional disorder, erotomanic type 17.44 11.35 5 89839 27 50515253
Hypercholesterolaemia 17.41 11.35 53 89791 11650 50503630
Toxic leukoencephalopathy 17.37 11.35 12 89832 631 50514649
Hypophagia 17.36 11.35 96 89748 27632 50487648
Areflexia 17.34 11.35 23 89821 2757 50512523
Foot fracture 17.28 11.35 7 89837 20084 50495196
Cellulitis 17.20 11.35 66 89778 70732 50444548
Drug withdrawal syndrome 17.17 11.35 89 89755 24992 50490288
Cyclothymic disorder 17.14 11.35 6 89838 67 50515213
Hypersomnia 17.14 11.35 63 89781 15251 50500029
Myocardial hypoxia 16.96 11.35 4 89840 8 50515272
Ketosis-prone diabetes mellitus 16.96 11.35 4 89840 8 50515272
Extensor plantar response 16.91 11.35 15 89829 1139 50514141
Glutamate dehydrogenase increased 16.86 11.35 5 89839 31 50515249
Malignant catatonia 16.86 11.35 7 89837 128 50515152
Torticollis 16.85 11.35 18 89826 1718 50513562
Immunodeficiency 16.81 11.35 3 89841 14825 50500455
Fungal infection 16.81 11.35 17 89827 29948 50485332
Type 1 diabetes mellitus 16.77 11.35 24 89820 3089 50512191
Sinus disorder 16.59 11.35 6 89838 18452 50496828
Seasonal allergy 16.57 11.35 3 89841 14673 50500607
Incontinence 16.56 11.35 47 89797 9938 50505342
Brief psychotic disorder, with postpartum onset 16.47 11.35 5 89839 34 50515246
Cystitis 16.41 11.35 34 89810 44530 50470750
Echopraxia 16.35 11.35 4 89840 10 50515270
Morose 16.22 11.35 5 89839 36 50515244
Opisthotonus 16.20 11.35 9 89835 320 50514960
Therapy partial responder 16.16 11.35 36 89808 6555 50508725
Newborn persistent pulmonary hypertension 16.15 11.35 7 89837 143 50515137
Osteonecrosis 16.12 11.35 10 89834 22507 50492773
Decreased gait velocity 16.08 11.35 4 89840 11 50515269
Grunting 16.05 11.35 8 89836 227 50515053
Muscle twitching 16.04 11.35 62 89782 15369 50499911
Excessive masturbation 16.01 11.35 3 89841 0 50515280
Intermittent explosive disorder 16.01 11.35 3 89841 0 50515280
Neurosyphilis 16.01 11.35 3 89841 0 50515280
Inborn error of metabolism 16.01 11.35 3 89841 0 50515280
Microphthalmos 15.97 11.35 7 89837 147 50515133
Atonic urinary bladder 15.91 11.35 6 89838 84 50515196
Full blood count decreased 15.90 11.35 10 89834 22336 50492944
Transient aphasia 15.87 11.35 5 89839 39 50515241
Flight of ideas 15.87 11.35 9 89835 333 50514947
Dysgeusia 15.81 11.35 28 89816 38888 50476392
Haemorrhoids 15.80 11.35 7 89837 19046 50496234
Tendonitis 15.76 11.35 5 89839 16700 50498580
Electrocardiogram QT interval abnormal 15.76 11.35 7 89837 152 50515128
Single umbilical artery 15.70 11.35 8 89836 238 50515042
Large for dates baby 15.57 11.35 10 89834 465 50514815
Sluggishness 15.50 11.35 28 89816 4385 50510895
Skin disorder 15.45 11.35 12 89832 24018 50491262
CSF glucose increased 15.45 11.35 5 89839 43 50515237
International normalised ratio abnormal 15.44 11.35 22 89822 2821 50512459
Hyperglycaemic hyperosmolar nonketotic syndrome 15.42 11.35 11 89833 609 50514671
High density lipoprotein decreased 15.41 11.35 17 89827 1683 50513597
Homicidal ideation 15.39 11.35 17 89827 1685 50513595
Drug level above therapeutic 15.23 11.35 26 89818 3894 50511386
Helplessness 15.22 11.35 8 89836 254 50515026
Accidental death 15.05 11.35 17 89827 1727 50513553
Blood alkaline phosphatase increased 14.96 11.35 116 89728 37410 50477870
Lipids abnormal 14.89 11.35 8 89836 266 50515014
Suspected suicide attempt 14.85 11.35 6 89838 102 50515178
Ear pain 14.81 11.35 17 89827 28266 50487014
Upper gastrointestinal haemorrhage 14.78 11.35 5 89839 16030 50499250
Product use in unapproved indication 14.69 11.35 288 89556 115531 50399749
Cerebral atrophy 14.66 11.35 28 89816 4573 50510707
Product quality issue 14.64 11.35 20 89824 30838 50484442
Rash macular 14.60 11.35 8 89836 19269 50496011
Communication disorder 14.55 11.35 19 89825 2242 50513038
Toxic encephalopathy 14.52 11.35 31 89813 5484 50509796
Soliloquy 14.50 11.35 7 89837 185 50515095
Accelerated hypertension 14.48 11.35 9 89835 395 50514885
Ulcer 14.43 11.35 9 89835 20191 50495089
Pneumonia 14.41 11.35 538 89306 377863 50137417
Amaurosis 14.41 11.35 10 89834 530 50514750
Affective ambivalence 14.38 11.35 4 89840 19 50515261
Oral candidiasis 14.37 11.35 6 89838 16909 50498371
Body mass index increased 14.37 11.35 13 89831 1013 50514267
Metastases to bone 14.32 11.35 7 89837 17988 50497292
Metastases to liver 14.30 11.35 9 89835 20095 50495185
Slow response to stimuli 14.16 11.35 12 89832 857 50514423
Hypertransaminasaemia 14.09 11.35 24 89820 3587 50511693
Foetal exposure during pregnancy 14.09 11.35 90 89754 27269 50488011
Hyperlipidaemia 14.08 11.35 65 89779 17425 50497855
Urinary incontinence 14.04 11.35 92 89752 28116 50487164
Gastrointestinal lymphoma 14.04 11.35 5 89839 59 50515221
Compulsive sexual behaviour 14.04 11.35 5 89839 59 50515221
Joint effusion 13.99 11.35 3 89841 13018 50502262
Brief psychotic disorder with marked stressors 13.96 11.35 5 89839 60 50515220
Facial wasting 13.93 11.35 3 89841 3 50515277
Pelvic sepsis 13.93 11.35 3 89841 3 50515277
Dyskinesia neonatal 13.93 11.35 3 89841 3 50515277
Onychogryphosis 13.93 11.35 3 89841 3 50515277
Asocial behaviour 13.89 11.35 4 89840 22 50515258
Enuresis 13.87 11.35 18 89826 2111 50513169
Alcohol abuse 13.86 11.35 17 89827 1884 50513396
Malignant neoplasm progression 13.81 11.35 68 89776 68056 50447224
Skin striae 13.74 11.35 13 89831 1073 50514207
Muscle tone disorder 13.74 11.35 6 89838 125 50515155
Muscle contractions involuntary 13.71 11.35 17 89827 1905 50513375
Slow speech 13.71 11.35 14 89830 1268 50514012
Glucocorticoids increased 13.69 11.35 6 89838 126 50515154
Illness 13.68 11.35 14 89830 24526 50490754
Sneezing 13.62 11.35 4 89840 14040 50501240
Hepatic function abnormal 13.58 11.35 102 89742 32579 50482701
Blood urea decreased 13.53 11.35 18 89826 2164 50513116
Blood pressure fluctuation 13.47 11.35 27 89817 35796 50479484
Myelodysplastic syndrome 13.46 11.35 5 89839 15127 50500153
Gastrooesophageal reflux disease 13.44 11.35 80 89764 76348 50438932
Acute myeloid leukaemia 13.38 11.35 5 89839 15069 50500211
Haematocrit increased 13.35 11.35 17 89827 1957 50513323
Neuroglycopenia 13.33 11.35 5 89839 69 50515211
Chronic kidney disease 13.29 11.35 32 89812 39739 50475541
Metamyelocyte count increased 13.27 11.35 7 89837 224 50515056
Moaning 13.26 11.35 11 89833 763 50514517
Alcohol use 13.21 11.35 17 89827 1978 50513302
Coagulation factor VII level decreased 13.20 11.35 5 89839 71 50515209
Chorea 13.19 11.35 14 89830 1326 50513954
Fear 13.17 11.35 56 89788 14493 50500787
Oral pain 13.16 11.35 15 89829 25018 50490262
Pituitary tumour benign 13.11 11.35 16 89828 1765 50513515
Hospitalisation 13.10 11.35 181 89663 67756 50447524
Glassy eyes 13.01 11.35 5 89839 74 50515206
Crying 12.99 11.35 71 89773 20345 50494935
Palmar-plantar erythrodysaesthesia syndrome 12.97 11.35 10 89834 20088 50495192
Ventricular arrhythmia 12.92 11.35 22 89822 3287 50511993
Mean cell haemoglobin decreased 12.86 11.35 22 89822 3301 50511979
Inappropriate affect 12.86 11.35 11 89833 796 50514484
Reduced facial expression 12.85 11.35 15 89829 1579 50513701
Blood glucose 12.84 11.35 4 89840 30 50515250
Lip swelling 12.81 11.35 15 89829 24721 50490559
Gastrointestinal haemorrhage 12.76 11.35 77 89767 73244 50442036
Dry skin 12.73 11.35 37 89807 43154 50472126
Hypersomnia-bulimia syndrome 12.72 11.35 3 89841 6 50515274
Alveolar capillary dysplasia 12.72 11.35 3 89841 6 50515274
Hyperinsulinism 12.72 11.35 3 89841 6 50515274
Ovarian germ cell cancer stage II 12.72 11.35 4 89840 31 50515249
Anterograde amnesia 12.70 11.35 9 89835 493 50514787
Drug withdrawal syndrome neonatal 12.68 11.35 16 89828 1825 50513455
Drug abuser 12.67 11.35 20 89824 2808 50512472
Alcoholism 12.65 11.35 15 89829 1605 50513675
Deafness 12.65 11.35 6 89838 15685 50499595
Dysbiosis 12.61 11.35 10 89834 650 50514630
Grip strength decreased 12.61 11.35 3 89841 12118 50503162
Incoherent 12.58 11.35 25 89819 4205 50511075
Device related infection 12.53 11.35 11 89833 20724 50494556
Red blood cells urine 12.53 11.35 9 89835 504 50514776
Terminal insomnia 12.49 11.35 10 89834 659 50514621
Tic 12.49 11.35 13 89831 1204 50514076
Heart rate decreased 12.49 11.35 29 89815 36468 50478812
Mouth ulceration 12.47 11.35 19 89825 28005 50487275
Pulmonary fibrosis 12.46 11.35 15 89829 24422 50490858
Dysphonia 12.45 11.35 32 89812 38860 50476420
Platelet count increased 12.42 11.35 55 89789 14485 50500795
Pupillary reflex impaired 12.41 11.35 16 89828 1865 50513415
Pseudobulbar palsy 12.41 11.35 3 89841 7 50515273
Consciousness fluctuating 12.36 11.35 10 89834 669 50514611
Tachyphrenia 12.24 11.35 13 89831 1232 50514048
Anger 12.16 11.35 46 89798 11287 50503993
Thirst 12.07 11.35 44 89800 10606 50504674
Wrong patient received product 12.07 11.35 15 89829 1685 50513595
Drug resistance 12.06 11.35 66 89778 18923 50496357
Hyponatraemic syndrome 12.05 11.35 9 89835 535 50514745
Hypomagnesaemia 12.03 11.35 14 89830 23142 50492138
Immune-mediated encephalitis 12.02 11.35 5 89839 92 50515188
Epileptic psychosis 12.00 11.35 4 89840 38 50515242
Limb injury 11.93 11.35 11 89833 20239 50495041
Female sexual dysfunction 11.91 11.35 4 89840 39 50515241
Thought insertion 11.86 11.35 3 89841 9 50515271
Analgesic drug level increased 11.85 11.35 15 89829 1716 50513564
Delusional disorder, persecutory type 11.85 11.35 6 89838 176 50515104
Myoglobin blood increased 11.84 11.35 13 89831 1280 50514000
Prolactin-producing pituitary tumour 11.82 11.35 5 89839 96 50515184
Antipsychotic drug level below therapeutic 11.72 11.35 7 89837 286 50514994
Diabetic neuropathy 11.63 11.35 22 89822 3569 50511711
Procedural pain 11.60 11.35 5 89839 13827 50501453
Osteopenia 11.59 11.35 8 89836 17010 50498270
Premature delivery 11.57 11.35 15 89829 23648 50491632
Hyperinsulinaemia 11.54 11.35 5 89839 102 50515178
Tongue biting 11.54 11.35 13 89831 1317 50513963
Pseudomembranous colitis 11.52 11.35 19 89825 2766 50512514
Joint injury 11.51 11.35 13 89831 21776 50493504
Right ventricular failure 11.46 11.35 7 89837 15886 50499394
Drug use disorder 11.44 11.35 20 89824 3052 50512228

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1681.52 12.12 885 94071 15263 29464308
Sedation 1029.81 12.12 661 94295 16744 29462827
Post-injection delirium sedation syndrome 1024.69 12.12 247 94709 203 29479368
Psychotic disorder 764 12.12 585 94371 19769 29459802
Agitation 637.49 12.12 804 94152 50500 29429071
Weight increased 629.92 12.12 985 93971 75682 29403889
Overdose 602.98 12.12 987 93969 78832 29400739
Akathisia 577.55 12.12 325 94631 6417 29473154
Suicide attempt 557.07 12.12 615 94341 33495 29446076
Schizophrenia 555.69 12.12 314 94642 6251 29473320
Extrapyramidal disorder 547.38 12.12 373 94583 10458 29469113
Aggression 522.90 12.12 607 94349 34934 29444637
Intentional self-injury 471.47 12.12 360 94596 12101 29467470
Delusion 457.59 12.12 339 94617 10877 29468694
Hallucination, auditory 441.64 12.12 312 94644 9281 29470290
Sopor 402.93 12.12 311 94645 10623 29468948
Catatonia 376.20 12.12 213 94743 4255 29475316
Blood creatine phosphokinase increased 352.62 12.12 536 94420 40108 29439463
Parkinsonism 340.31 12.12 239 94717 7039 29472532
Mania 340.31 12.12 256 94700 8407 29471164
Prescribed overdose 333.14 12.12 253 94703 8430 29471141
Dystonia 328.38 12.12 263 94693 9486 29470085
Somnolence 321.37 12.12 838 94118 93117 29386454
Intentional overdose 318.62 12.12 497 94459 38031 29441540
Diarrhoea 311.72 12.12 367 94589 332331 29147240
Muscle rigidity 298.22 12.12 245 94711 9166 29470405
Toxicity to various agents 293.59 12.12 1218 93738 172443 29307128
Diabetes mellitus 286.07 12.12 482 94474 39349 29440222
Myocarditis 283.57 12.12 254 94702 10702 29468869
Electrocardiogram QT prolonged 276.56 12.12 450 94506 35687 29443884
Arthralgia 264.41 12.12 62 94894 139555 29340016
Tachycardia 260.00 12.12 658 94298 71752 29407819
Tardive dyskinesia 251.26 12.12 175 94781 5083 29474488
Dysarthria 248.93 12.12 394 94562 30517 29449054
Psychotic symptom 248.42 12.12 111 94845 1303 29478268
Completed suicide 247.49 12.12 743 94213 89503 29390068
Salivary hypersecretion 243.41 12.12 197 94759 7212 29472359
Delirium 241.79 12.12 445 94511 38952 29440619
Mental impairment 230.80 12.12 209 94747 8932 29470639
Blood triglycerides increased 227.84 12.12 242 94714 12592 29466979
Restlessness 225.28 12.12 315 94641 21830 29457741
Abnormal behaviour 222.04 12.12 320 94636 22807 29456764
Hyperprolactinaemia 220.90 12.12 99 94857 1171 29478400
Oculogyric crisis 220.60 12.12 101 94855 1260 29478311
Priapism 218.26 12.12 151 94805 4337 29475234
Type 2 diabetes mellitus 218.26 12.12 243 94713 13338 29466233
Blood prolactin abnormal 209.09 12.12 85 94871 775 29478796
Dyspnoea 208.36 12.12 464 94492 326268 29153303
Metabolic syndrome 197.79 12.12 96 94860 1377 29478194
Suicidal ideation 189.36 12.12 373 94583 34343 29445228
Rash 187.50 12.12 200 94756 189619 29289952
Depressed level of consciousness 182.58 12.12 381 94575 36561 29443010
Increased appetite 181.98 12.12 153 94803 5911 29473660
Coma 177.89 12.12 392 94564 39058 29440513
Treatment noncompliance 174.94 12.12 294 94662 23933 29455638
Paranoia 174.88 12.12 186 94770 9691 29469880
Fatigue 173.75 12.12 486 94470 316335 29163236
Pain 172.21 12.12 178 94778 171254 29308317
Anosognosia 169.05 12.12 72 94884 746 29478825
Dyskinesia 167.42 12.12 260 94696 19801 29459770
Hypothermia 165.37 12.12 175 94781 9064 29470507
Diabetic ketoacidosis 164.00 12.12 229 94727 15844 29463727
Disinhibition 163.95 12.12 103 94853 2504 29477067
Nausea 162.05 12.12 439 94517 288816 29190755
Blood prolactin increased 159.22 12.12 84 94872 1450 29478121
Anaemia 159.00 12.12 250 94706 200701 29278870
Pruritus 151.49 12.12 94 94862 116755 29362816
Sexual dysfunction 150.84 12.12 135 94821 5679 29473892
Antipsychotic drug level below therapeutic 147.26 12.12 87 94869 1887 29477684
Confusional state 144.35 12.12 799 94157 127078 29352493
Metabolic disorder 140.24 12.12 107 94849 3588 29475983
Malignant neoplasm progression 137.32 12.12 34 94922 73825 29405746
Disorientation 136.11 12.12 296 94660 29219 29450352
Emotional poverty 133.70 12.12 52 94904 417 29479154
Obsessive-compulsive disorder 132.27 12.12 113 94843 4463 29475108
Pneumonia 132.08 12.12 555 94401 319617 29159954
Serotonin syndrome 131.07 12.12 216 94740 17296 29462275
Polydipsia 130.76 12.12 100 94856 3365 29476206
Obesity 129.32 12.12 159 94797 9704 29469867
Disturbance in social behaviour 126.93 12.12 75 94881 1627 29477944
Cough 123.34 12.12 135 94821 126592 29352979
Euphoric mood 121.16 12.12 110 94846 4715 29474856
Diabetic coma 120.53 12.12 56 94900 724 29478847
Blood cholesterol increased 120.29 12.12 195 94761 15400 29464171
Psychomotor hyperactivity 120.16 12.12 140 94816 8073 29471498
Pain in extremity 117.32 12.12 109 94847 110324 29369247
Death 116.55 12.12 635 94321 341449 29138122
Acute kidney injury 116.11 12.12 449 94507 264818 29214753
Schizoaffective disorder 113.91 12.12 60 94896 1032 29478539
Thinking abnormal 113.48 12.12 110 94846 5126 29474445
Rhabdomyolysis 113.08 12.12 440 94516 60368 29419203
Cardiac failure congestive 111.75 12.12 53 94903 76528 29403043
Speech disorder 109.74 12.12 237 94719 23279 29456292
Tremor 109.38 12.12 497 94459 73041 29406530
Disease progression 107.36 12.12 65 94891 81851 29397720
Drug interaction 105.30 12.12 1031 93925 196354 29283217
Negativism 104.86 12.12 41 94915 334 29479237
Granulocytopenia 104.55 12.12 112 94844 5882 29473689
Dyslipidaemia 103.52 12.12 112 94844 5949 29473622
Atrial fibrillation 103.37 12.12 112 94844 105534 29374037
Irritability 100.80 12.12 221 94735 21931 29457640
Psychiatric decompensation 98.56 12.12 61 94895 1443 29478128
Urticaria 94.40 12.12 29 94927 54631 29424940
Gastrointestinal haemorrhage 93.66 12.12 71 94885 79462 29400109
Mental disorder 93.65 12.12 157 94799 12748 29466823
Interstitial lung disease 92.10 12.12 35 94921 57683 29421888
Therapeutic product effect variable 90.90 12.12 63 94893 1814 29477757
Anxiety 90.65 12.12 525 94431 84840 29394731
Miosis 90.61 12.12 120 94836 7889 29471682
Leukopenia 88.80 12.12 382 94574 54821 29424750
Headache 88.48 12.12 276 94680 173731 29305840
Back pain 87.83 12.12 120 94836 102164 29377407
Type 1 diabetes mellitus 87.45 12.12 81 94875 3563 29476008
Joint swelling 86.31 12.12 26 94930 49604 29429967
Rheumatoid arthritis 86.28 12.12 4 94952 32148 29447423
Infusion related reaction 85.95 12.12 18 94938 43868 29435703
Pneumonia aspiration 85.41 12.12 286 94670 36451 29443120
Febrile neutropenia 84.53 12.12 144 94812 112096 29367475
Antipsychotic drug level above therapeutic 83.37 12.12 49 94907 1052 29478519
Delusional disorder, persecutory type 82.83 12.12 31 94925 221 29479350
Decreased appetite 81.55 12.12 220 94736 145122 29334449
Hepatic steatosis 79.53 12.12 159 94797 14787 29464784
Renal impairment 77.58 12.12 88 94868 81245 29398326
Persecutory delusion 76.88 12.12 60 94896 2081 29477490
Anticholinergic syndrome 76.27 12.12 43 94913 851 29478720
Bradykinesia 75.80 12.12 73 94883 3374 29476197
Neuropathy peripheral 75.51 12.12 70 94886 70957 29408614
Apathy 75.33 12.12 96 94860 6075 29473496
Peripheral swelling 74.90 12.12 57 94899 63682 29415889
Dyspnoea exertional 73.47 12.12 14 94942 36476 29443095
White blood cell count increased 73.42 12.12 276 94680 37240 29442331
Oedema peripheral 72.46 12.12 139 94817 103418 29376153
Sinus tachycardia 70.44 12.12 152 94804 14917 29464654
Hypomania 69.67 12.12 57 94899 2118 29477453
Drug abuse 69.58 12.12 467 94489 79416 29400155
Renal failure 69.18 12.12 176 94780 118423 29361148
Bradyphrenia 68.71 12.12 76 94880 4138 29475433
Antipsychotic drug level increased 68.16 12.12 67 94889 3176 29476395
Social avoidant behaviour 67.91 12.12 64 94892 2878 29476693
Erythema 67.64 12.12 86 94870 75520 29404051
Neutrophil count increased 66.97 12.12 147 94809 14595 29464976
Bipolar disorder 65.43 12.12 66 94890 3229 29476342
Pleurothotonus 65.24 12.12 41 94915 997 29478574
Eosinophilic myocarditis 65.17 12.12 31 94925 424 29479147
Abdominal pain 63.71 12.12 222 94734 135135 29344436
Drug hypersensitivity 63.09 12.12 76 94880 68330 29411241
Drooling 62.73 12.12 62 94894 2959 29476612
Heat stroke 62.45 12.12 38 94918 871 29478700
Herpes zoster 61.64 12.12 11 94945 30041 29449530
Hallucination 61.15 12.12 295 94661 44417 29435154
Tension 61.00 12.12 50 94906 1863 29477708
Blepharospasm 59.69 12.12 39 94917 1016 29478555
Psoriasis 59.55 12.12 15 94941 32212 29447359
Haemorrhage 58.69 12.12 36 94920 45036 29434535
International normalised ratio increased 58.40 12.12 35 94921 44337 29435234
Loss of consciousness 58.05 12.12 422 94534 73634 29405937
Infection 57.26 12.12 99 94857 76652 29402919
Influenza 56.59 12.12 32 94924 41849 29437722
Withdrawal syndrome 56.17 12.12 115 94841 10877 29468694
Obsessive thoughts 56.01 12.12 31 94925 591 29478980
Agranulocytosis 55.16 12.12 167 94789 20173 29459398
Delusion of grandeur 54.84 12.12 27 94929 400 29479171
Psychiatric symptom 54.66 12.12 59 94897 3125 29476446
Asthenia 53.69 12.12 438 94518 214812 29264759
Spasmodic dysphonia 53.52 12.12 17 94939 68 29479503
Visceral congestion 53.24 12.12 28 94928 480 29479091
Nasopharyngitis 53.22 12.12 68 94888 59597 29419974
Water intoxication 52.94 12.12 26 94930 383 29479188
Weight decreased 52.86 12.12 277 94679 150628 29328943
Stomatitis 52.12 12.12 27 94929 37086 29442485
Respiratory depression 51.69 12.12 126 94830 13397 29466174
Melaena 51.25 12.12 18 94938 31158 29448413
Thrombosis 51.20 12.12 38 94918 43007 29436564
Sepsis 51.05 12.12 260 94696 142422 29337149
Plasma cell myeloma 50.66 12.12 28 94928 37087 29442484
Self-injurious ideation 50.42 12.12 41 94915 1510 29478061
Hypertriglyceridaemia 50.36 12.12 88 94868 7387 29472184
Product dose omission issue 50.24 12.12 151 94805 96232 29383339
Septic shock 50.12 12.12 77 94879 62483 29417088
Cerebrovascular accident 49.73 12.12 108 94848 76803 29402768
Feeling guilty 49.52 12.12 23 94933 297 29479274
Sudden death 49.25 12.12 127 94829 13983 29465588
Hallucination, visual 49.20 12.12 132 94824 14883 29464688
General physical health deterioration 48.84 12.12 168 94788 102689 29376882
Hyperammonaemia 48.07 12.12 74 94882 5589 29473982
Hyperkalaemia 47.81 12.12 77 94879 61315 29418256
Obsessive-compulsive symptom 47.50 12.12 16 94940 80 29479491
Coma scale abnormal 47.21 12.12 57 94899 3412 29476159
Prostate cancer 46.93 12.12 12 94944 25515 29454056
Hyperglycaemia 46.71 12.12 226 94730 34061 29445510
Refusal of treatment by patient 46.56 12.12 66 94890 4628 29474943
Rebound psychosis 46.53 12.12 18 94938 142 29479429
Arthropathy 46.19 12.12 7 94949 21547 29458024
Cognitive disorder 46.06 12.12 173 94783 23326 29456245
Unresponsive to stimuli 45.99 12.12 181 94775 24945 29454626
Cardiomyopathy 45.47 12.12 127 94829 14660 29464911
Insomnia 45.39 12.12 460 94496 88301 29391270
Ascites 45.29 12.12 31 94925 36588 29442983
Depressive symptom 44.79 12.12 40 94916 1677 29477894
Cytomegalovirus infection 44.47 12.12 10 94946 23205 29456366
Mutism 44.26 12.12 28 94928 689 29478882
COVID-19 43.86 12.12 31 94925 35983 29443588
Musculoskeletal pain 43.82 12.12 19 94937 28934 29450637
Grandiosity 43.27 12.12 21 94935 301 29479270
Pancreatitis necrotising 42.96 12.12 45 94911 2302 29477269
Delusion of replacement 42.88 12.12 16 94940 113 29479458
Cogwheel rigidity 42.84 12.12 34 94922 1209 29478362
Intentional product use issue 42.70 12.12 44 94912 42454 29437117
Pleural effusion 42.44 12.12 106 94850 71802 29407769
Abdominal discomfort 42.30 12.12 55 94901 47848 29431723
Derealisation 41.83 12.12 25 94931 554 29479017
Mucosal inflammation 41.46 12.12 25 94931 31570 29448001
Chills 41.39 12.12 106 94850 71194 29408377
Acute myocardial infarction 41.36 12.12 57 94899 48381 29431190
Sinusitis 41.27 12.12 30 94926 34320 29445251
Suspiciousness 41.19 12.12 20 94936 287 29479284
Chronic kidney disease 40.96 12.12 34 94922 36382 29443189
Cardiac failure 40.75 12.12 125 94831 79162 29400409
Injection site pain 40.75 12.12 27 94929 32419 29447152
Haemoglobin decreased 40.75 12.12 194 94762 108181 29371390
Stupor 40.51 12.12 47 94909 2697 29476874
Asthma 40.10 12.12 30 94926 33819 29445752
Blood glucose increased 40.00 12.12 325 94631 58659 29420912
Drug ineffective 39.93 12.12 1482 93474 361688 29117883
Personality change 39.92 12.12 61 94895 4577 29474994
Gout 39.88 12.12 4 94952 16907 29462664
Blood creatinine increased 39.72 12.12 140 94816 84962 29394609
Diverticulitis 39.70 12.12 5 94951 17699 29461872
Haematuria 39.67 12.12 50 94906 44089 29435482
Hanging 39.60 12.12 15 94941 111 29479460
Angina pectoris 39.49 12.12 20 94936 27830 29451741
Xanthoma 39.45 12.12 14 94942 84 29479487
Poisoning deliberate 39.30 12.12 68 94888 5663 29473908
Psychomotor retardation 39.04 12.12 48 94908 2928 29476643
Product substitution issue 38.90 12.12 89 94867 9083 29470488
Anaphylactic reaction 38.80 12.12 20 94936 27553 29452018
Altered state of consciousness 38.63 12.12 146 94810 19743 29459828
Logorrhoea 38.58 12.12 42 94914 2246 29477325
Arthritis 38.53 12.12 16 94940 25003 29454568
Hyperreflexia 38.47 12.12 46 94910 2726 29476845
Eye movement disorder 38.19 12.12 53 94903 3643 29475928
Erectile dysfunction 38.17 12.12 136 94820 17873 29461698
Overweight 38.10 12.12 34 94922 1424 29478147
Inappropriate affect 38.00 12.12 23 94933 522 29479049
Productive cough 37.94 12.12 27 94929 31232 29448339
Pulmonary embolism 37.86 12.12 394 94562 76140 29403431
Hyperlipidaemia 37.60 12.12 107 94849 12483 29467088
Breast engorgement 37.55 12.12 9 94947 7 29479564
Pneumonitis 37.06 12.12 22 94934 28022 29451549
Eosinophil count decreased 36.94 12.12 30 94926 1103 29478468
Hypervolaemia 36.91 12.12 6 94950 17539 29462032
Nephrolithiasis 36.21 12.12 18 94938 25316 29454255
Myocardial infarction 36.10 12.12 207 94749 110089 29369482
Staphylococcal infection 35.83 12.12 25 94931 29215 29450356
Disturbance in attention 35.77 12.12 150 94806 21274 29458297
Diabetic hyperosmolar coma 35.40 12.12 19 94937 340 29479231
Colitis 35.36 12.12 29 94927 31219 29448352
Hypersensitivity 35.26 12.12 73 94883 52830 29426741
Aspiration 34.88 12.12 91 94865 10089 29469482
Coronary artery disease 34.80 12.12 55 94901 44135 29435436
Hyponatraemia 34.79 12.12 351 94605 67282 29412289
Enuresis 34.70 12.12 38 94918 2046 29477525
Flat affect 34.69 12.12 25 94931 767 29478804
Troponin increased 34.50 12.12 85 94871 9098 29470473
Faecaloma 34.39 12.12 54 94902 4148 29475423
Food craving 34.10 12.12 18 94938 311 29479260
Eosinophil count increased 34.05 12.12 74 94882 7295 29472276
Muscle spasms 33.87 12.12 102 94854 64980 29414591
Wheezing 33.86 12.12 34 94922 33206 29446365
Sedation complication 33.71 12.12 30 94926 1252 29478319
Cold-stimulus headache 33.21 12.12 7 94949 0 29479571
Muscular weakness 33.20 12.12 96 94860 61956 29417615
Haematochezia 33.12 12.12 42 94914 36941 29442630
Neutrophil count decreased 32.82 12.12 246 94710 43321 29436250
Multiple organ dysfunction syndrome 32.79 12.12 99 94857 63017 29416554
Generalised tonic-clonic seizure 32.73 12.12 135 94821 19004 29460567
Candida infection 32.49 12.12 5 94951 15220 29464351
Full blood count decreased 32.48 12.12 6 94950 15986 29463585
Pancytopenia 32.36 12.12 147 94809 83021 29396550
Antisocial behaviour 32.29 12.12 17 94939 292 29479279
Hyperglycaemic hyperosmolar nonketotic syndrome 32.10 12.12 27 94929 1043 29478528
Oral discharge 32.03 12.12 13 94943 118 29479453
Wrong patient received product 31.88 12.12 38 94918 2244 29477327
Fluid retention 31.82 12.12 18 94938 23542 29456029
Physical assault 31.80 12.12 27 94929 1057 29478514
Impulsive behaviour 31.60 12.12 35 94921 1908 29477663
Megacolon 31.59 12.12 32 94924 1573 29477998
Torticollis 31.56 12.12 27 94929 1068 29478503
Hallucinations, mixed 31.53 12.12 39 94917 2394 29477177
Ketoacidosis 31.51 12.12 48 94908 3591 29475980
Mydriasis 31.49 12.12 64 94892 6021 29473550
Epistaxis 31.46 12.12 75 94881 51629 29427942
Asphyxia 31.26 12.12 59 94897 5256 29474315
Delusional disorder, unspecified type 31.10 12.12 22 94934 655 29478916
Colitis ischaemic 31.03 12.12 62 94894 5761 29473810
Skin exfoliation 31.02 12.12 17 94939 22628 29456943
Angioedema 30.99 12.12 34 94922 31881 29447690
Poisoning 30.89 12.12 86 94870 9907 29469664
Bronchitis 30.86 12.12 44 94912 36824 29442747
Mental status changes 30.85 12.12 205 94751 34722 29444849
Autonomic nervous system imbalance 30.65 12.12 38 94918 2338 29477233
Selective eating disorder 30.64 12.12 32 94924 1631 29477940
Swelling 30.64 12.12 41 94915 35242 29444329
Hyperphagia 30.60 12.12 28 94928 1212 29478359
Encephalitis toxic 30.59 12.12 16 94940 271 29479300
Long QT syndrome 30.56 12.12 37 94919 2221 29477350
Peptostreptococcus infection 30.56 12.12 9 94947 26 29479545
Osteoarthritis 30.54 12.12 10 94946 18093 29461478
Hunger 30.48 12.12 29 94927 1320 29478251
Neoplasm progression 30.15 12.12 11 94945 18601 29460970
Posture abnormal 29.84 12.12 34 94922 1913 29477658
Brain injury 29.75 12.12 59 94897 5453 29474118
Myelodysplastic syndrome 29.72 12.12 10 94946 17784 29461787
Affective disorder 29.61 12.12 43 94913 3083 29476488
Urinary incontinence 29.57 12.12 118 94838 16363 29463208
Multiple drug therapy 29.55 12.12 17 94939 350 29479221
Prostatic specific antigen increased 29.55 12.12 3 94953 12561 29467010
Hyperbilirubinaemia 29.49 12.12 6 94950 14928 29464643
Hypercholesterolaemia 29.34 12.12 69 94887 7169 29472402
Thrombocytopenia 29.30 12.12 284 94672 134539 29345032
Urinary tract infection 29.28 12.12 126 94830 72228 29407343
White blood cell count decreased 29.27 12.12 402 94554 82960 29396611
Bipolar I disorder 29.21 12.12 22 94934 723 29478848
Judgement impaired 28.97 12.12 20 94936 572 29478999
Inappropriate antidiuretic hormone secretion 28.92 12.12 89 94867 10843 29468728
Restless legs syndrome 28.77 12.12 67 94889 6917 29472654
Unevaluable event 28.76 12.12 32 94924 29819 29449752
Withdrawal catatonia 28.63 12.12 11 94945 85 29479486
Pressure of speech 28.56 12.12 18 94938 440 29479131
Paradoxical embolism 28.47 12.12 6 94950 0 29479571
Hypertonia 28.33 12.12 47 94909 3782 29475789
Haematoma 28.24 12.12 20 94936 23192 29456379
Staring 28.07 12.12 28 94928 1351 29478220
Somatic symptom disorder 28.07 12.12 19 94937 526 29479045
Chest discomfort 27.74 12.12 67 94889 45916 29433655
Hyperhidrosis 27.66 12.12 323 94633 64217 29415354
Cerebrovascular stenosis 27.57 12.12 11 94945 95 29479476
Protrusion tongue 27.38 12.12 13 94943 177 29479394
Pulmonary fibrosis 27.37 12.12 8 94948 15574 29463997
Dysphagia 27.26 12.12 283 94673 54643 29424928
Neutropenia 27.21 12.12 583 94373 131128 29348443
Dyspepsia 27.20 12.12 34 94922 30091 29449480
Waxy flexibility 26.99 12.12 11 94945 101 29479470
Dysgeusia 26.98 12.12 20 94936 22654 29456917
Myalgia 26.93 12.12 134 94822 73885 29405686
Drug withdrawal syndrome neonatal 26.92 12.12 43 94913 3352 29476219
Perseveration 26.80 12.12 11 94945 103 29479468
Respiratory arrest 26.79 12.12 158 94798 25675 29453896
Blunted affect 26.60 12.12 15 94941 297 29479274
Tumour lysis syndrome 26.55 12.12 6 94950 13878 29465693
Alanine aminotransferase increased 26.50 12.12 346 94610 70598 29408973
Osteonecrosis of jaw 26.34 12.12 10 94946 16500 29463071
Ataxia 26.16 12.12 92 94864 12011 29467560
Dehydration 26.08 12.12 239 94717 114509 29365062
Incoherent 26.05 12.12 47 94909 4045 29475526
Camptocormia 25.84 12.12 12 94944 155 29479416
Leukocytosis 25.72 12.12 135 94821 21007 29458564
Urinary retention 25.67 12.12 183 94773 31715 29447856
Rhinorrhoea 25.58 12.12 19 94937 21500 29458071
Illness anxiety disorder 25.56 12.12 12 94944 159 29479412
Psychotic behaviour 25.48 12.12 19 94937 615 29478956
Dysphonia 25.45 12.12 15 94941 19181 29460390
Rebound effect 25.43 12.12 32 94924 1999 29477572
Dementia with Lewy bodies 25.37 12.12 19 94937 619 29478952
Myoclonus 25.27 12.12 97 94859 13212 29466359
Metastases to liver 25.06 12.12 4 94952 11852 29467719
Malignant catatonia 24.97 12.12 13 94943 218 29479353
Electroencephalogram abnormal 24.90 12.12 34 94922 2301 29477270
Agitated depression 24.81 12.12 13 94943 221 29479350
Aspartate aminotransferase increased 24.75 12.12 297 94659 59428 29420143
Hepatitis C virus test positive 24.48 12.12 14 94942 285 29479286
Chronic obstructive pulmonary disease 24.45 12.12 60 94896 40895 29438676
Oedema 24.41 12.12 59 94897 40424 29439147
Bronchopulmonary aspergillosis 24.29 12.12 5 94951 12339 29467232
Depressed mood 24.28 12.12 111 94845 16337 29463234
Hospitalisation 24.28 12.12 240 94716 45748 29433823
Pulmonary mass 24.19 12.12 3 94953 10745 29468826
Impaired self-care 24.19 12.12 22 94934 945 29478626
Cerebellar syndrome 24.06 12.12 31 94925 1983 29477588
Myelosuppression 23.96 12.12 5 94951 12222 29467349
Rash pruritic 23.79 12.12 22 94934 22341 29457230
Exhibitionism 23.75 12.12 8 94948 40 29479531
Resting tremor 23.70 12.12 18 94938 599 29478972
Ileus paralytic 23.62 12.12 52 94904 5171 29474400
Upper respiratory tract infection 23.53 12.12 32 94924 27317 29452254
Skin ulcer 23.22 12.12 16 94940 18824 29460747
Choreoathetosis 23.18 12.12 22 94934 998 29478573
Major depression 23.09 12.12 43 94913 3792 29475779
Laboratory test abnormal 23.01 12.12 15 94941 18170 29461401
Suicidal behaviour 22.92 12.12 25 94931 1340 29478231
Delusional perception 22.90 12.12 11 94945 154 29479417
High density lipoprotein decreased 22.62 12.12 37 94919 2942 29476629
Alcohol use 22.58 12.12 38 94918 3094 29476477
Gamma-glutamyltransferase increased 22.46 12.12 155 94801 26582 29452989
Hyperthermia 22.42 12.12 74 94882 9356 29470215
Bladder cancer 22.37 12.12 3 94953 10124 29469447
Fungal infection 22.32 12.12 8 94948 13677 29465894
Hepatic failure 22.27 12.12 42 94914 31470 29448101
Paradoxical drug reaction 22.12 12.12 35 94921 2706 29476865
Disorganised speech 22.09 12.12 18 94938 665 29478906
Osteonecrosis 21.88 12.12 8 94948 13511 29466060
Flatulence 21.88 12.12 15 94941 17694 29461877
Salivary gland calculus 21.88 12.12 8 94948 53 29479518
Compulsive sexual behaviour 21.81 12.12 12 94944 226 29479345
Patient restraint 21.77 12.12 9 94947 86 29479485
Acute myeloid leukaemia 21.75 12.12 13 94943 16500 29463071
Somnambulism 21.59 12.12 35 94921 2763 29476808
Substance abuse 21.56 12.12 59 94897 6728 29472843
Confabulation 21.54 12.12 10 94946 129 29479442
Proteinuria 21.45 12.12 12 94944 15792 29463779
Injection site erythema 21.37 12.12 9 94947 13947 29465624
Intentional product misuse 21.37 12.12 187 94769 34474 29445097
Hallucination, olfactory 21.37 12.12 11 94945 180 29479391
Red cell distribution width decreased 21.32 12.12 11 94945 181 29479390
Abdominal pain upper 21.29 12.12 112 94844 60881 29418690
Drug level above therapeutic 21.05 12.12 38 94918 3272 29476299
Bone pain 21.03 12.12 17 94939 18435 29461136
Symptom masked 20.95 12.12 16 94940 537 29479034
Blood creatine phosphokinase MB increased 20.92 12.12 27 94929 1730 29477841
Gynaecomastia 20.91 12.12 66 94890 8151 29471420
Pancreatitis haemorrhagic 20.87 12.12 13 94943 311 29479260
Sexually inappropriate behaviour 20.67 12.12 14 94942 388 29479183
Alcohol abuse 20.58 12.12 44 94912 4289 29475282
Upper gastrointestinal haemorrhage 20.56 12.12 24 94932 21890 29457681
C-reactive protein increased 20.53 12.12 225 94731 44038 29435533
Squamous cell carcinoma 20.49 12.12 4 94952 10247 29469324
Tubulointerstitial nephritis 20.43 12.12 16 94940 17627 29461944
Cerebral haemorrhage 20.40 12.12 44 94912 31382 29448189
Panic attack 20.39 12.12 66 94890 8260 29471311
Ejaculation disorder 20.35 12.12 20 94936 948 29478623
Transient ischaemic attack 20.24 12.12 27 94929 23243 29456328
Neoplasm malignant 20.04 12.12 15 94941 16910 29462661
Bone marrow failure 19.92 12.12 36 94920 27413 29452158
Abulia 19.84 12.12 15 94941 496 29479075
Contusion 19.80 12.12 44 94912 31051 29448520
Frequent bowel movements 19.79 12.12 3 94953 9236 29470335
Gastrointestinal sounds abnormal 19.76 12.12 27 94929 1829 29477742
Total cholesterol/HDL ratio increased 19.57 12.12 10 94946 161 29479410
Blister 19.55 12.12 21 94935 19885 29459686
Abnormal weight gain 19.55 12.12 19 94937 888 29478683
Polyuria 19.54 12.12 60 94896 7302 29472269
Eosinophilia 19.52 12.12 130 94826 22031 29457540
Somatic hallucination 19.51 12.12 6 94950 21 29479550
Clostridium difficile colitis 19.47 12.12 9 94947 13203 29466368
Body temperature increased 19.44 12.12 95 94861 14370 29465201
Blood ketone body 19.39 12.12 8 94948 76 29479495
Anxiolytic therapy 19.30 12.12 6 94950 22 29479549
Drug monitoring procedure incorrectly performed 19.23 12.12 11 94945 224 29479347
Thirst 19.22 12.12 55 94901 6436 29473135
Osteomyelitis 19.20 12.12 10 94946 13699 29465872
Pulmonary valve incompetence 19.09 12.12 17 94939 710 29478861
Cellulitis 19.05 12.12 79 94877 45761 29433810
Blood thrombin increased 18.98 12.12 4 94952 0 29479571
Illiteracy 18.97 12.12 5 94951 8 29479563
Haemoptysis 18.83 12.12 44 94912 30506 29449065
Impaired healing 18.83 12.12 10 94946 13548 29466023
Wrong technique in product usage process 18.79 12.12 46 94910 31382 29448189
Rash erythematous 18.78 12.12 25 94931 21537 29458034
Homicidal ideation 18.70 12.12 31 94925 2493 29477078
Globulins decreased 18.68 12.12 10 94946 178 29479393
Behaviour disorder 18.67 12.12 38 94918 3578 29475993
Acute psychosis 18.65 12.12 25 94931 1662 29477909
Depression 18.58 12.12 380 94576 84767 29394804
Stereotypy 18.49 12.12 16 94940 643 29478928
Dry skin 18.35 12.12 29 94927 23278 29456293
Drug level increased 18.27 12.12 113 94843 18674 29460897
Contraindicated product administered 18.24 12.12 19 94937 18247 29461324
Hypoaesthesia 18.20 12.12 99 94857 53368 29426203
Blood pressure increased 17.96 12.12 151 94805 73652 29405919
Hypotonia neonatal 17.92 12.12 21 94935 1218 29478353
Renal disorder 17.90 12.12 28 94928 22567 29457004
Electrocardiogram QT shortened 17.89 12.12 9 94947 140 29479431
Pulmonary hypertension 17.87 12.12 20 94936 18588 29460983
Embolism venous 17.87 12.12 22 94934 1344 29478227
Asocial behaviour 17.80 12.12 7 94949 58 29479513
Lung disorder 17.71 12.12 45 94911 30317 29449254
Drug therapy enhancement 17.65 12.12 6 94950 31 29479540
Hypomagnesaemia 17.64 12.12 18 94938 17450 29462121
Pyrexia 17.58 12.12 750 94206 286872 29192699
Palmar-plantar erythrodysaesthesia syndrome 17.58 12.12 13 94943 14746 29464825
Reduced facial expression 17.54 12.12 16 94940 690 29478881
Bacteraemia 17.43 12.12 16 94940 16307 29463264
Sleep disorder 17.41 12.12 136 94820 24250 29455321
Lipids increased 17.39 12.12 17 94939 800 29478771
Epilepsy 17.38 12.12 110 94846 18322 29461249
Haemophagocytic lymphohistiocytosis 17.37 12.12 6 94950 10498 29469073
Rectal haemorrhage 17.36 12.12 55 94901 34494 29445077
Respiration abnormal 17.34 12.12 31 94925 2649 29476922
Troponin I increased 17.28 12.12 26 94930 1924 29477647
Inflammation 17.22 12.12 29 94927 22699 29456872
Neurodegenerative disorder 17.21 12.12 10 94946 210 29479361
Sluggishness 17.19 12.12 33 94923 2978 29476593
Body mass index increased 17.13 12.12 17 94939 815 29478756
Clostridium difficile infection 17.03 12.12 16 94940 16125 29463446
Blood bilirubin increased 17.00 12.12 54 94902 33839 29445732
Blood creatine phosphokinase decreased 16.98 12.12 13 94943 438 29479133
Posterior reversible encephalopathy syndrome 16.92 12.12 4 94952 8972 29470599
Faeces discoloured 16.91 12.12 11 94945 13340 29466231
Ageusia 16.82 12.12 4 94952 8934 29470637
Mobility decreased 16.81 12.12 36 94920 25744 29453827
Polydipsia psychogenic 16.72 12.12 8 94948 111 29479460
Neuralgia 16.67 12.12 7 94949 10867 29468704
Cor pulmonale acute 16.64 12.12 10 94946 224 29479347
Tangentiality 16.59 12.12 8 94948 113 29479458
Product use issue 16.57 12.12 97 94859 51347 29428224
Cataract 16.55 12.12 29 94927 22349 29457222
Neglect of personal appearance 16.53 12.12 8 94948 114 29479457
Therapeutic product effect incomplete 16.52 12.12 196 94760 39109 29440462
Antipsychotic drug level decreased 16.51 12.12 17 94939 852 29478719
Oromandibular dystonia 16.46 12.12 13 94943 459 29479112
Anger 16.45 12.12 74 94882 10816 29468755
Lymphocyte count increased 16.41 12.12 31 94925 2763 29476808
Hyperosmolar state 16.40 12.12 12 94944 377 29479194
Joint stiffness 16.39 12.12 5 94951 9468 29470103
Coagulopathy 16.38 12.12 20 94936 17887 29461684
Soliloquy 16.37 12.12 12 94944 378 29479193
Galactorrhoea 16.26 12.12 12 94944 382 29479189
Off label use 16.24 12.12 795 94161 300005 29179566
Paraphilia 16.23 12.12 7 94949 75 29479496
Vascular stenosis 16.20 12.12 9 94947 173 29479398
Gastrointestinal hypermotility 16.10 12.12 8 94948 121 29479450
Circadian rhythm sleep disorder 16.10 12.12 12 94944 388 29479183
Depersonalisation/derealisation disorder 16.08 12.12 14 94942 567 29479004
Condition aggravated 15.96 12.12 597 94359 145698 29333873
Device related infection 15.91 12.12 16 94940 15620 29463951
Dysphoria 15.91 12.12 26 94930 2066 29477505
Myotonia 15.89 12.12 6 94950 44 29479527
Parkinsonian rest tremor 15.87 12.12 8 94948 125 29479446
Movement disorder 15.80 12.12 70 94886 10167 29469404
Benign ethnic neutropenia 15.77 12.12 6 94950 45 29479526
Antisocial personality disorder 15.74 12.12 5 94951 20 29479551
Adrenal insufficiency 15.73 12.12 8 94948 11106 29468465
Skin lesion 15.70 12.12 22 94934 18550 29461021
Illusion 15.69 12.12 15 94941 687 29478884
Chromaturia 15.61 12.12 11 94945 12791 29466780
Basophil count decreased 15.60 12.12 7 94949 83 29479488
Cyclothymic disorder 15.60 12.12 7 94949 83 29479488
Head banging 15.59 12.12 8 94948 130 29479441
Pain in jaw 15.57 12.12 9 94947 11632 29467939
Hostility 15.56 12.12 16 94940 801 29478770
Drug withdrawal syndrome 15.54 12.12 105 94851 17879 29461692
Affect lability 15.53 12.12 34 94922 3368 29476203
Night sweats 15.52 12.12 15 94941 14917 29464654
Hyperammonaemic encephalopathy 15.50 12.12 25 94931 1965 29477606
Drug level below therapeutic 15.48 12.12 39 94917 4232 29475339
Hepatitis viral 15.37 12.12 13 94943 506 29479065
Renal tubular necrosis 15.33 12.12 14 94942 14301 29465270
Snoring 15.27 12.12 30 94926 2754 29476817
Homosexuality 15.23 12.12 6 94950 50 29479521
Gastrectomy 15.11 12.12 8 94948 139 29479432
Angina unstable 15.11 12.12 8 94948 10857 29468714
Glassy eyes 15.10 12.12 7 94949 90 29479481
Graft versus host disease 15.08 12.12 6 94950 9622 29469949
Injection site bruising 15.06 12.12 3 94953 7577 29471994
Hypometabolism 14.92 12.12 6 94950 53 29479518
Chemical poisoning 14.90 12.12 7 94949 93 29479478
Osteoporosis 14.87 12.12 8 94948 10761 29468810
Somatic delusion 14.70 12.12 7 94949 96 29479475
Seizure 14.60 12.12 397 94559 92726 29386845
Left ventricular dysfunction 14.60 12.12 62 94894 8840 29470731
Pathogen resistance 14.57 12.12 4 94952 8112 29471459
Personality disorder 14.55 12.12 18 94938 1105 29478466
Injection site swelling 14.54 12.12 6 94950 9411 29470160
Generalised anxiety disorder 14.54 12.12 14 94942 647 29478924
Strabismus congenital 14.53 12.12 5 94951 27 29479544
Ear infection 14.52 12.12 4 94952 8096 29471475
Intestinal perforation 14.48 12.12 4 94952 8082 29471489
Cardiac dysfunction 14.48 12.12 23 94933 1784 29477787
Cholestasis 14.29 12.12 34 94922 23428 29456143
Thrombotic microangiopathy 14.28 12.12 5 94951 8676 29470895
Cardio-respiratory arrest 14.24 12.12 235 94721 50366 29429205
Lipomeningocele 14.23 12.12 3 94953 0 29479571
Schizoid personality disorder 14.23 12.12 3 94953 0 29479571
Gastric haemorrhage 14.23 12.12 6 94950 9291 29470280
Tic 14.22 12.12 23 94933 1812 29477759
Glycosylated haemoglobin increased 14.20 12.12 64 94892 9362 29470209
Metastases to bone 14.19 12.12 7 94949 9891 29469680
Accidental overdose 14.19 12.12 101 94855 17492 29462079
Hyperinsulinism 14.19 12.12 6 94950 61 29479510
Blood loss anaemia 14.18 12.12 3 94953 7263 29472308
Myoglobin blood increased 14.11 12.12 24 94932 1971 29477600
Tricuspid valve sclerosis 14.09 12.12 5 94951 30 29479541
Cerebellar atrophy 14.00 12.12 12 94944 476 29479095
Drug eruption 13.98 12.12 20 94936 16721 29462850
Flushing 13.98 12.12 47 94909 28945 29450626
Blood urea decreased 13.97 12.12 16 94940 905 29478666
Cataract congenital 13.93 12.12 6 94950 64 29479507
Pancreatic carcinoma 13.85 12.12 3 94953 7147 29472424
Oropharyngeal pain 13.76 12.12 48 94908 29237 29450334
Mixed delusion 13.73 12.12 4 94952 11 29479560
Multiple sclerosis relapse 13.68 12.12 10 94946 11409 29468162
Pseudomonas infection 13.66 12.12 9 94947 10843 29468728
Staphylococcal bacteraemia 13.66 12.12 3 94953 7076 29472495
Dextrocardia 13.63 12.12 7 94949 114 29479457
Legal problem 13.60 12.12 8 94948 172 29479399
Trismus 13.53 12.12 26 94930 2347 29477224
Drowning 13.53 12.12 11 94945 405 29479166
Secondary tic 13.47 12.12 4 94952 12 29479559
Selective mutism 13.46 12.12 6 94950 70 29479501
Electrocardiogram PR prolongation 13.35 12.12 14 94942 717 29478854
Tongue biting 13.32 12.12 14 94942 719 29478852
Granulocyte count decreased 13.32 12.12 13 94943 611 29478960
Surgery 13.24 12.12 11 94945 11768 29467803
Anaphylactic shock 13.17 12.12 14 94942 13322 29466249
Thought blocking 13.11 12.12 7 94949 124 29479447
Visual impairment 13.10 12.12 50 94906 29658 29449913
Localised infection 13.10 12.12 15 94941 13801 29465770
Eating disorder 13.09 12.12 52 94904 7195 29472376
Accidental death 13.07 12.12 24 94932 2094 29477477
Leukaemia 12.99 12.12 34 94922 3776 29475795
Disseminated intravascular coagulation 12.95 12.12 28 94928 19952 29459619
Saccadic eye movement 12.86 12.12 7 94949 129 29479442
Hypotonia 12.85 12.12 50 94906 6852 29472719
Family stress 12.76 12.12 7 94949 131 29479440
Motor dysfunction 12.75 12.12 45 94911 5885 29473686
Echolalia 12.72 12.12 9 94947 268 29479303
Cytokine release syndrome 12.71 12.12 14 94942 13105 29466466
Hypokinesia 12.69 12.12 53 94903 7501 29472070
Oliguria 12.67 12.12 4 94952 7408 29472163
Product prescribing error 12.66 12.12 24 94932 17952 29461619
Gambling disorder 12.56 12.12 20 94936 1555 29478016
Gastric ulcer 12.55 12.12 16 94940 14045 29465526
Vascular encephalopathy 12.48 12.12 7 94949 137 29479434
Gait disturbance 12.45 12.12 316 94640 73033 29406538
Platelet count decreased 12.44 12.12 249 94707 104423 29375148
Foetal alcohol syndrome 12.44 12.12 7 94949 138 29479433
Abscess 12.42 12.12 8 94948 9754 29469817
Hyperventilation 12.41 12.12 25 94931 2337 29477234
Transfusion 12.36 12.12 4 94952 7294 29472277
Poor quality sleep 12.35 12.12 51 94905 7182 29472389
Cardiogenic shock 12.34 12.12 27 94929 19163 29460408
Pancreatitis 12.32 12.12 167 94789 34347 29445224
Paraesthesia 12.28 12.12 112 94844 53733 29425838
Persistent depressive disorder 12.18 12.12 9 94947 287 29479284
Inferiority complex 12.16 12.12 3 94953 3 29479568
Glutamate dehydrogenase increased 12.16 12.12 3 94953 3 29479568
Drug use disorder 12.14 12.12 31 94925 3391 29476180

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 2854.58 11.20 1329 153331 23667 64320405
Sedation 1567.71 11.20 1067 153593 40395 64303677
Suicide attempt 1309.13 11.20 1196 153464 69811 64274261
Post-injection delirium sedation syndrome 1281.95 11.20 289 154371 239 64343833
Agitation 1092.38 11.20 1198 153462 87169 64256903
Psychotic disorder 1043.88 11.20 776 153884 33802 64310270
Extrapyramidal disorder 1041.77 11.20 625 154035 18927 64325145
Sopor 986.84 11.20 706 153954 28955 64315117
Intentional self-injury 965.56 11.20 691 153969 28353 64315719
Akathisia 947.83 11.20 490 154170 11020 64333052
Intentional overdose 916.98 11.20 1104 153556 88840 64255232
Overdose 856.10 11.20 1441 153219 158125 64185947
Schizophrenia 827.37 11.20 443 154217 10725 64333347
Dystonia 786.01 11.20 516 154144 18349 64325723
Delusion 773.22 11.20 502 154158 17512 64326560
Aggression 756.11 11.20 729 153931 45503 64298569
Catatonia 710.91 11.20 353 154307 7267 64336805
Blood prolactin abnormal 700.16 11.20 259 154401 2473 64341599
Hallucination, auditory 700.05 11.20 461 154199 16478 64327594
Toxicity to various agents 692.83 11.20 2177 152483 361336 63982736
Sexual dysfunction 649.16 11.20 315 154345 6156 64337916
Arthralgia 641.79 11.20 139 154521 442121 63901951
Parkinsonism 635.22 11.20 408 154252 13965 64330107
Somnolence 621.63 11.20 1452 153208 202193 64141879
Electrocardiogram QT prolonged 596.71 11.20 839 153821 78609 64265463
Anosognosia 596.34 11.20 232 154428 2573 64341499
Completed suicide 563.45 11.20 1485 153175 222929 64121143
Mania 546.94 11.20 390 154270 15896 64328176
Muscle rigidity 526.82 11.20 392 154268 17081 64326991
Pain 515.17 11.20 349 154311 553162 63790910
Disturbance in social behaviour 513.62 11.20 229 154431 3658 64340414
Weight increased 498.47 11.20 1375 153285 211973 64132099
Hyperprolactinaemia 491.20 11.20 225 154435 3840 64340232
Metabolic disorder 489.25 11.20 276 154384 7421 64336651
Dyskinesia 479.22 11.20 530 154130 38858 64305214
Salivary hypersecretion 474.75 11.20 319 154341 11794 64332278
Blood creatine phosphokinase increased 458.40 11.20 631 154029 57927 64286145
Tardive dyskinesia 449.29 11.20 278 154382 8900 64335172
Delirium 447.39 11.20 681 153979 68513 64275559
Drug interaction 440.11 11.20 1875 152785 360208 63983864
Diarrhoea 427.07 11.20 673 153987 722031 63622041
Drug abuse 407.95 11.20 948 153712 131426 64212646
Tachycardia 406.14 11.20 1020 153640 148559 64195513
Coma 401.48 11.20 739 153921 86876 64257196
Suicidal ideation 394.08 11.20 629 154031 65913 64278159
Restlessness 380.14 11.20 473 154187 39312 64304760
Abnormal behaviour 370.85 11.20 430 154230 33192 64310880
Oculogyric crisis 369.24 11.20 160 154500 2378 64341694
Hypothermia 364.53 11.20 334 154326 19522 64324550
Depressed level of consciousness 359.47 11.20 676 153984 80760 64263312
Treatment noncompliance 351.51 11.20 476 154184 43006 64301066
Metabolic syndrome 351.36 11.20 151 154509 2197 64341875
Rheumatoid arthritis 347.70 11.20 10 154650 164284 64179788
Psychomotor hyperactivity 346.18 11.20 283 154377 14168 64329904
Personality change 340.81 11.20 228 154432 8365 64335707
Dyspnoea 338.39 11.20 767 153893 717907 63626165
Fatigue 331.15 11.20 826 153834 747904 63596168
Prescribed overdose 331.10 11.20 320 154340 20011 64324061
Blood prolactin increased 327.76 11.20 163 154497 3365 64340707
Pleurothotonus 321.48 11.20 141 154519 2161 64341911
Dysarthria 318.56 11.20 537 154123 58869 64285203
Rash 313.24 11.20 384 154276 458165 63885907
Headache 300.94 11.20 505 154155 528962 63815110
Myocarditis 294.14 11.20 277 154383 16766 64327306
Confusional state 289.87 11.20 1317 153343 259827 64084245
Paranoia 286.49 11.20 268 154392 16084 64327988
Joint swelling 280.51 11.20 84 154576 215298 64128774
Psychotic symptom 279.41 11.20 125 154535 2013 64342059
Pruritus 278.11 11.20 206 154454 312194 64031878
Infusion related reaction 263.24 11.20 40 154620 164427 64179645
Hypomania 260.97 11.20 165 154495 5489 64338583
Miosis 243.20 11.20 223 154437 13043 64331029
Pain in extremity 241.13 11.20 223 154437 302862 64041210
Mental impairment 236.08 11.20 241 154419 16102 64327970
Diabetes mellitus 230.24 11.20 499 154161 65975 64278097
Cough 229.11 11.20 232 154428 301916 64042156
Arthropathy 227.95 11.20 16 154644 120951 64223121
Hallucination 227.00 11.20 524 154136 72264 64271808
Peripheral swelling 226.66 11.20 109 154551 209044 64135028
Drug hypersensitivity 223.20 11.20 148 154512 237667 64106405
Priapism 222.03 11.20 131 154529 3839 64340233
Nausea 219.61 11.20 1055 153605 784745 63559327
Tremor 215.78 11.20 813 153847 147417 64196655
Back pain 213.61 11.20 172 154488 249999 64094073
Sinusitis 212.92 11.20 45 154615 145883 64198189
Rhabdomyolysis 211.58 11.20 589 154071 91137 64252935
Social avoidant behaviour 207.86 11.20 132 154528 4425 64339647
Persecutory delusion 201.10 11.20 125 154535 4033 64340039
Abdominal discomfort 199.08 11.20 94 154566 182228 64161844
Nasopharyngitis 197.90 11.20 112 154548 195961 64148111
Disorientation 197.81 11.20 423 154237 55405 64288667
Granulocytopenia 194.31 11.20 177 154483 10263 64333809
Pneumonia aspiration 194.01 11.20 435 154225 58836 64285236
Hypersensitivity 188.74 11.20 119 154541 196333 64147739
Urticaria 187.16 11.20 60 154600 147257 64196815
Swelling 186.97 11.20 75 154585 160143 64183929
Antipsychotic drug level above therapeutic 178.87 11.20 88 154572 1773 64342299
Polydipsia 176.33 11.20 131 154529 5690 64338382
Bradyphrenia 176.09 11.20 160 154500 9246 64334826
Serotonin syndrome 175.60 11.20 328 154332 38954 64305118
Blood triglycerides increased 168.58 11.20 217 154443 18649 64325423
Obesity 164.45 11.20 224 154436 20338 64323734
Anxiety 164.19 11.20 936 153724 201713 64142359
Alopecia 162.42 11.20 98 154562 165592 64178480
Blood glucose increased 162.26 11.20 561 154099 97512 64246560
Negativism 162.04 11.20 63 154597 697 64343375
Antipsychotic drug level increased 161.44 11.20 118 154542 4997 64339075
Injection site pain 155.21 11.20 38 154622 111370 64232702
Camptocormia 154.86 11.20 54 154606 427 64343645
Irritability 150.93 11.20 296 154364 36450 64307622
Contraindicated product administered 147.85 11.20 38 154622 107791 64236281
Psychiatric decompensation 147.60 11.20 85 154575 2378 64341694
Apathy 145.00 11.20 156 154504 11076 64332996
Mental disorder 141.62 11.20 239 154421 26206 64317866
Leukopenia 137.99 11.20 544 154116 100698 64243374
Diabetic ketoacidosis 135.64 11.20 251 154409 29594 64314478
Thinking abnormal 134.48 11.20 152 154508 11404 64332668
Anaemia 133.82 11.20 463 154197 378217 63965855
Speech disorder 131.92 11.20 331 154329 48110 64295962
Obsessive-compulsive disorder 131.74 11.20 102 154558 4716 64339356
Increased appetite 131.12 11.20 141 154519 10005 64334067
Gestational diabetes 128.70 11.20 107 154553 5483 64338589
Psychomotor retardation 127.98 11.20 103 154557 5040 64339032
Schizoaffective disorder 126.13 11.20 66 154594 1521 64342551
Arthritis 126.07 11.20 24 154636 83790 64260282
Diabetic coma 125.43 11.20 59 154601 1072 64343000
Respiratory depression 124.38 11.20 211 154449 23232 64320840
Bipolar disorder 122.65 11.20 113 154547 6648 64337424
Type 2 diabetes mellitus 121.90 11.20 259 154401 33761 64310311
Pulmonary embolism 119.77 11.20 678 153982 145678 64198394
Drug intolerance 118.21 11.20 167 154493 187825 64156247
Posture abnormal 115.33 11.20 82 154578 3324 64340748
Psychiatric symptom 114.10 11.20 105 154555 6168 64337904
Emotional poverty 114.05 11.20 48 154612 661 64343411
Bradykinesia 113.90 11.20 107 154553 6453 64337619
Injection site erythema 113.72 11.20 17 154643 70783 64273289
Stomatitis 111.40 11.20 62 154598 109543 64234529
Systemic lupus erythematosus 111.00 11.20 25 154635 77587 64266485
Mutism 110.82 11.20 66 154594 1968 64342104
Sinus tachycardia 110.68 11.20 241 154419 31947 64312125
Obsessive thoughts 109.56 11.20 52 154608 965 64343107
Infection 108.71 11.20 172 154488 184708 64159364
Galactorrhoea 107.85 11.20 77 154583 3142 64340930
Cardiac failure congestive 107.37 11.20 93 154567 130487 64213585
Herpes zoster 106.47 11.20 29 154631 79158 64264914
Glossodynia 105.15 11.20 15 154645 64681 64279391
Obsessive-compulsive symptom 104.29 11.20 30 154630 114 64343958
Loss of consciousness 102.08 11.20 657 154003 147708 64196364
Interstitial lung disease 101.19 11.20 54 154606 97678 64246394
Generalised tonic-clonic seizure 100.93 11.20 265 154395 39592 64304480
Osteoarthritis 99.92 11.20 16 154644 63320 64280752
Orthostatic hypertension 98.60 11.20 42 154618 597 64343475
Respiratory arrest 98.18 11.20 315 154345 52670 64291402
Product dose omission issue 97.62 11.20 200 154460 194547 64149525
Disinhibition 97.42 11.20 63 154597 2180 64341892
Cardio-respiratory arrest 97.04 11.20 480 154180 97913 64246159
Impaired healing 96.03 11.20 15 154645 60458 64283614
Erythema 94.71 11.20 191 154469 186879 64157193
Neutropenia 94.28 11.20 933 153727 238691 64105381
Neuropathy peripheral 93.86 11.20 86 154574 117439 64226633
Unresponsive to stimuli 93.74 11.20 300 154360 50093 64293979
Influenza 93.65 11.20 71 154589 106460 64237612
White blood cell count increased 91.76 11.20 357 154303 65657 64278415
Neutrophil count increased 90.58 11.20 192 154468 24982 64319090
Cogwheel rigidity 90.46 11.20 66 154594 2787 64341285
Dyspnoea exertional 90.17 11.20 32 154628 73698 64270374
Sudden death 90.04 11.20 168 154492 19928 64324144
Chest discomfort 89.17 11.20 88 154572 116018 64228054
Atrial fibrillation 88.92 11.20 172 154488 170917 64173155
Anaphylactic reaction 88.89 11.20 27 154633 68637 64275435
Therapeutic product effect decreased 87.93 11.20 88 154572 115263 64228809
Psoriasis 87.89 11.20 31 154629 71672 64272400
Drooling 87.11 11.20 84 154576 5235 64338837
Hallucinations, mixed 86.95 11.20 89 154571 5963 64338109
Disease progression 86.93 11.20 128 154532 141552 64202520
Hyponatraemia 84.36 11.20 627 154033 147712 64196360
Euphoric mood 84.13 11.20 91 154569 6500 64337572
Depressive symptom 81.27 11.20 75 154585 4421 64339651
Musculoskeletal pain 81.15 11.20 47 154613 81247 64262825
Malignant neoplasm progression 80.57 11.20 91 154569 112780 64231292
Blister 80.55 11.20 47 154613 80920 64263152
Coma scale abnormal 80.00 11.20 96 154564 7678 64336394
Cognitive disorder 79.09 11.20 301 154359 54786 64289286
Mobility decreased 78.32 11.20 55 154605 85785 64258287
Psoriatic arthropathy 77.94 11.20 7 154653 43274 64300798
Gastrointestinal haemorrhage 77.84 11.20 123 154537 132189 64211883
Injection site pruritus 77.50 11.20 3 154657 37823 64306249
Dyslipidaemia 77.43 11.20 103 154557 9139 64334933
Self-injurious ideation 77.38 11.20 63 154597 3134 64340938
Asthma 76.85 11.20 69 154591 95156 64248916
White blood cell count decreased 76.49 11.20 643 154017 157194 64186878
Altered state of consciousness 76.37 11.20 232 154428 37670 64306402
Pneumonia 76.32 11.20 917 153743 558659 63785413
Refusal of treatment by patient 76.20 11.20 97 154563 8242 64335830
Disturbance in attention 75.92 11.20 244 154416 40830 64303242
Antipsychotic drug level below therapeutic 75.54 11.20 40 154620 945 64343127
Insurance issue 75.47 11.20 59 154601 2767 64341305
Substance abuse 73.95 11.20 101 154559 9191 64334881
Feeling guilty 73.43 11.20 37 154623 786 64343286
Megacolon 73.05 11.20 60 154600 3022 64341050
Wheezing 73.03 11.20 52 154608 80527 64263545
Urinary tract infection 72.68 11.20 297 154363 231299 64112773
Hallucination, visual 72.45 11.20 187 154473 27647 64316425
Intentional product use issue 72.40 11.20 73 154587 95291 64248781
Logorrhoea 72.00 11.20 67 154593 3992 64340080
Type 1 diabetes mellitus 71.47 11.20 78 154582 5627 64338445
Hypoaesthesia 71.27 11.20 141 154519 138967 64205105
Hyperthermia 70.92 11.20 131 154529 15419 64328653
Injection site bruising 70.91 11.20 4 154656 36369 64307703
Abdominal pain 70.55 11.20 449 154211 311926 64032146
Abdominal pain upper 70.14 11.20 202 154458 174828 64169244
Poisoning deliberate 69.90 11.20 120 154540 13338 64330734
Stupor 69.57 11.20 79 154581 5956 64338116
Seizure 68.61 11.20 656 154004 166236 64177836
Product use issue 68.47 11.20 165 154495 151550 64192522
Rebound psychosis 68.15 11.20 22 154638 133 64343939
Urinary retention 67.49 11.20 265 154395 48936 64295136
Myalgia 67.32 11.20 178 154482 158439 64185633
Malaise 67.12 11.20 617 154043 395630 63948442
Mental status changes 66.54 11.20 307 154353 60855 64283217
Agranulocytosis 66.08 11.20 222 154438 38007 64306065
Poisoning 65.41 11.20 155 154505 21724 64322348
Acute kidney injury 65.15 11.20 726 153934 448514 63895558
Hyperphagia 64.88 11.20 49 154611 2182 64341890
Acute psychosis 64.76 11.20 61 154599 3691 64340381
Wound 64.65 11.20 53 154607 76424 64267648
Lower respiratory tract infection 64.60 11.20 79 154581 94535 64249537
Grandiosity 64.28 11.20 30 154630 535 64343537
Depression 64.13 11.20 697 153963 182594 64161478
Injection site swelling 64.00 11.20 11 154649 41342 64302730
Eosinophilic myocarditis 63.65 11.20 34 154626 818 64343254
Contusion 63.26 11.20 110 154550 113855 64230217
Electroencephalogram abnormal 63.21 11.20 70 154590 5133 64338939
Delusion of grandeur 62.57 11.20 30 154630 570 64343502
Mydriasis 62.44 11.20 123 154537 15189 64328883
Withdrawal syndrome 62.35 11.20 159 154501 23333 64320739
Water intoxication 61.92 11.20 32 154628 718 64343354
Tension 61.67 11.20 60 154600 3780 64340292
Duodenal ulcer perforation 61.28 11.20 6 154654 34619 64309453
Heat stroke 61.07 11.20 40 154620 1415 64342657
Neutrophil count decreased 60.72 11.20 354 154306 76842 64267230
Waxy flexibility 60.18 11.20 23 154637 242 64343830
Amenorrhoea 59.65 11.20 76 154584 6463 64337609
Hyperammonaemia 59.09 11.20 94 154566 9810 64334262
Gastrointestinal disorder 59.07 11.20 77 154583 89632 64254440
Hyperammonaemic encephalopathy 58.88 11.20 60 154600 3998 64340074
Osteonecrosis of jaw 58.63 11.20 12 154648 39813 64304259
Upper respiratory tract infection 58.41 11.20 53 154607 72732 64271340
Basal cell carcinoma 58.29 11.20 4 154656 30834 64313238
Discomfort 57.94 11.20 65 154595 80813 64263259
Bronchitis 57.63 11.20 108 154552 108635 64235437
Bone pain 57.56 11.20 21 154639 47551 64296521
Muscle spasms 57.04 11.20 162 154498 140861 64203211
Polyuria 57.02 11.20 106 154554 12537 64331535
Weight decreased 56.94 11.20 426 154234 285313 64058759
Inflammation 56.77 11.20 44 154616 65256 64278816
Cardiac arrest 56.28 11.20 591 154069 153473 64190599
Diverticulitis 56.10 11.20 12 154648 38606 64305466
Delusional disorder, persecutory type 55.96 11.20 25 154635 401 64343671
Dyspepsia 55.95 11.20 66 154594 80246 64263826
Insomnia 55.83 11.20 722 153938 197114 64146958
Injection site reaction 55.79 11.20 21 154639 46643 64297429
Osteoporosis 55.46 11.20 16 154644 42064 64302008
Hypertonia 55.32 11.20 72 154588 6253 64337819
Impulsive behaviour 55.22 11.20 48 154612 2615 64341457
Asthenia 55.06 11.20 710 153950 427334 63916738
Treatment failure 54.33 11.20 125 154535 116691 64227381
Blood pressure increased 54.29 11.20 221 154439 172331 64171741
Behaviour disorder 54.16 11.20 60 154600 4402 64339670
COVID-19 54.00 11.20 46 154614 65094 64278978
Suspiciousness 53.99 11.20 27 154633 564 64343508
Bipolar I disorder 53.96 11.20 40 154620 1731 64342341
Inappropriate antidiuretic hormone secretion 53.19 11.20 145 154515 22144 64321928
Cytomegalovirus infection 53.15 11.20 12 154648 37187 64306885
Torsade de pointes 52.98 11.20 124 154536 17239 64326833
Jaundice cholestatic 52.71 11.20 83 154577 8587 64335485
Autonomic nervous system imbalance 52.65 11.20 57 154603 4075 64339997
Flat affect 52.27 11.20 40 154620 1817 64342255
International normalised ratio increased 52.07 11.20 68 154592 79099 64264973
Oropharyngeal pain 51.89 11.20 83 154577 88784 64255288
Muscular weakness 51.70 11.20 146 154514 127192 64216880
Depressed mood 51.56 11.20 215 154445 40797 64303275
Irritable bowel syndrome 51.53 11.20 13 154647 37356 64306716
Intentional product misuse 51.43 11.20 323 154337 71972 64272100
Staring 51.10 11.20 44 154616 2366 64341706
Screaming 50.88 11.20 52 154608 3477 64340595
Nasal congestion 50.85 11.20 41 154619 59617 64284455
Fluid retention 50.76 11.20 41 154619 59565 64284507
Somnambulism 50.48 11.20 62 154598 5079 64338993
Flushing 50.26 11.20 69 154591 78579 64265493
Productive cough 50.10 11.20 61 154599 73142 64270930
Renal failure 49.76 11.20 245 154415 181443 64162629
Mucosal inflammation 49.71 11.20 46 154614 62538 64281534
Renal impairment 49.67 11.20 162 154498 134855 64209217
Knee arthroplasty 49.62 11.20 4 154656 26995 64317077
Blunted affect 49.55 11.20 23 154637 405 64343667
Overweight 49.51 11.20 50 154610 3296 64340776
Eosinophil count decreased 49.42 11.20 45 154615 2607 64341465
Enuresis 49.38 11.20 46 154614 2744 64341328
Brain injury 49.33 11.20 87 154573 9878 64334194
Haematochezia 49.02 11.20 52 154608 66321 64277751
Rhinorrhoea 48.92 11.20 43 154617 59926 64284146
Folliculitis 48.81 11.20 7 154653 30070 64314002
Delusional disorder, unspecified type 48.52 11.20 27 154633 706 64343366
Delusion of replacement 48.36 11.20 17 154643 138 64343934
Leukocytosis 48.35 11.20 199 154461 37541 64306531
Visceral congestion 48.28 11.20 28 154632 794 64343278
Pressure of speech 48.17 11.20 30 154630 971 64343101
Sleep disorder due to general medical condition, insomnia type 47.98 11.20 4 154656 26266 64317806
Cataract 47.88 11.20 32 154628 51230 64292842
Trimethylaminuria 47.73 11.20 17 154643 144 64343928
Chills 47.57 11.20 169 154491 137095 64206977
Hyperglycaemia 47.56 11.20 279 154381 60689 64283383
Skin ulcer 47.44 11.20 23 154637 43951 64300121
Long QT syndrome 47.30 11.20 60 154600 5079 64338993
Affective disorder 47.13 11.20 68 154592 6512 64337560
Rash pruritic 47.02 11.20 41 154619 57363 64286709
Cor pulmonale acute 46.97 11.20 25 154635 597 64343475
Multiple sclerosis relapse 46.74 11.20 20 154640 41115 64302957
Somatic symptom disorder of pregnancy 46.70 11.20 15 154645 89 64343983
Neoplasm progression 46.42 11.20 20 154640 40944 64303128
Fibromyalgia 46.33 11.20 14 154646 35717 64308355
Ataxia 46.20 11.20 137 154523 21947 64322125
Spasmodic dysphonia 45.97 11.20 17 154643 162 64343910
Hypokinesia 45.79 11.20 114 154546 16482 64327590
Pulmonary mass 45.73 11.20 3 154657 24013 64320059
Nephrolithiasis 45.40 11.20 24 154636 43659 64300413
Anticholinergic syndrome 45.32 11.20 43 154617 2626 64341446
Haematuria 45.08 11.20 47 154613 60424 64283648
Pleural effusion 45.08 11.20 154 154506 126405 64217667
Major depression 45.01 11.20 73 154587 7743 64336329
Hypertriglyceridaemia 44.48 11.20 89 154571 11116 64332956
Chronic kidney disease 44.34 11.20 44 154616 57875 64286197
Thrombosis 44.12 11.20 63 154597 70579 64273493
Chest pain 44.10 11.20 358 154302 235622 64108450
Pancreatitis necrotising 43.86 11.20 46 154614 3171 64340901
Blepharospasm 43.78 11.20 47 154613 3328 64340744
Abulia 43.63 11.20 27 154633 864 64343208
General physical health deterioration 43.50 11.20 299 154361 204126 64139946
Maternal exposure during pregnancy 43.46 11.20 104 154556 95780 64248292
Eosinophil count increased 43.30 11.20 101 154559 14011 64330061
Hyperkalaemia 43.26 11.20 113 154547 101016 64243056
Ascites 43.14 11.20 51 154609 61950 64282122
Food craving 43.02 11.20 32 154628 1392 64342680
Cellulitis 42.92 11.20 101 154559 93556 64250516
Stereotypy 42.46 11.20 26 154634 816 64343256
Aspiration 42.46 11.20 112 154548 16773 64327299
Ileus paralytic 42.35 11.20 74 154586 8341 64335731
Embolism venous 42.29 11.20 47 154613 3460 64340612
Death 42.29 11.20 860 153800 481845 63862227
Throat irritation 42.09 11.20 13 154647 32698 64311374
Breast engorgement 42.05 11.20 12 154648 44 64344028
Hanging 41.99 11.20 14 154646 95 64343977
Feeling hot 41.99 11.20 29 154631 45634 64298438
Melaena 41.78 11.20 40 154620 53508 64290564
Decreased appetite 41.73 11.20 452 154208 280837 64063235
Erectile dysfunction 41.65 11.20 93 154567 12534 64331538
Alanine aminotransferase increased 41.58 11.20 513 154147 138518 64205554
Diabetic hyperosmolar coma 41.02 11.20 24 154636 692 64343380
Muscle injury 40.98 11.20 7 154653 26430 64317642
Angina pectoris 40.96 11.20 29 154631 45052 64299020
Skin exfoliation 40.62 11.20 29 154631 44856 64299216
Oromandibular dystonia 40.53 11.20 26 154634 887 64343185
Drug level increased 40.45 11.20 176 154484 34020 64310052
Self esteem decreased 40.43 11.20 26 154634 891 64343181
Asphyxia 40.41 11.20 78 154582 9488 64334584
Brain stem thrombosis 40.29 11.20 8 154652 0 64344072
Epilepsy 39.99 11.20 173 154487 33358 64310714
Fungal infection 39.97 11.20 16 154644 34235 64309837
Head banging 39.86 11.20 21 154639 491 64343581
Gout 39.83 11.20 3 154657 21410 64322662
Malignant catatonia 39.77 11.20 19 154641 358 64343714
Homicide 39.64 11.20 28 154632 1123 64342949
Hallucination, olfactory 39.26 11.20 20 154640 435 64343637
Eosinophilia 39.12 11.20 188 154472 37888 64306184
Pericarditis 38.79 11.20 56 154604 62460 64281612
Dementia with Lewy bodies 38.67 11.20 23 154637 684 64343388
Pain in jaw 38.66 11.20 25 154635 40730 64303342
Myoclonus 38.34 11.20 140 154520 24978 64319094
Abnormal weight gain 38.24 11.20 36 154624 2177 64341895
Illusion 38.13 11.20 31 154629 1539 64342533
Ketoacidosis 38.04 11.20 63 154597 6800 64337272
Unevaluable event 37.91 11.20 39 154621 50450 64293622
Hepatic steatosis 37.77 11.20 161 154499 30846 64313226
Accidental overdose 37.65 11.20 170 154490 33387 64310685
Delusion of reference 37.62 11.20 14 154646 136 64343936
Hyperhidrosis 37.38 11.20 461 154199 124459 64219613
Compulsive sexual behaviour 37.15 11.20 16 154644 234 64343838
Condition aggravated 36.93 11.20 1161 153499 371265 63972807
Torticollis 36.82 11.20 35 154625 2142 64341930
Ill-defined disorder 36.64 11.20 31 154629 44021 64300051
Withdrawal catatonia 36.49 11.20 14 154646 149 64343923
Migraine 36.15 11.20 59 154601 62618 64281454
Pneumocystis jirovecii pneumonia 35.52 11.20 11 154649 27623 64316449
Suicidal behaviour 35.35 11.20 39 154621 2848 64341224
Diet refusal 35.20 11.20 23 154637 810 64343262
Hypernatraemia 34.98 11.20 85 154575 12104 64331968
Cardiac failure 34.81 11.20 181 154479 132192 64211880
Gamma-glutamyltransferase increased 34.66 11.20 217 154443 48293 64295779
Sciatica 34.61 11.20 4 154656 20260 64323812
Neck pain 34.49 11.20 59 154601 61474 64282598
Neuralgia 34.42 11.20 10 154650 26174 64317898
Ejaculation disorder 34.42 11.20 19 154641 489 64343583
Burning sensation 34.39 11.20 41 154619 49623 64294449
Plasma cell mastitis 34.24 11.20 9 154651 22 64344050
Anaphylactic shock 34.06 11.20 15 154645 30313 64313759
Eye movement disorder 34.01 11.20 61 154599 7018 64337054
Thought blocking 33.85 11.20 14 154646 184 64343888
Impulse-control disorder 33.69 11.20 29 154631 1559 64342513
Hyperglycaemic hyperosmolar nonketotic syndrome 33.67 11.20 30 154630 1689 64342383
Metastases to liver 33.65 11.20 8 154652 23933 64320139
Acute myeloid leukaemia 33.43 11.20 12 154648 27451 64316621
Sepsis 33.40 11.20 372 154288 229969 64114103
Drug withdrawal syndrome 33.24 11.20 156 154504 31135 64312937
Negative symptoms in schizophrenia 33.06 11.20 12 154648 108 64343964
Gynaecomastia 33.04 11.20 55 154605 5961 64338111
Limb discomfort 32.87 11.20 12 154648 27163 64316909
Bone marrow failure 32.77 11.20 40 154620 47912 64296160
Drug monitoring procedure incorrectly performed 32.75 11.20 17 154643 385 64343687
Blood cholesterol increased 32.74 11.20 219 154441 49847 64294225
Joint stiffness 32.65 11.20 16 154644 30388 64313684
Paraesthesia 32.59 11.20 189 154471 134333 64209739
Epistaxis 32.56 11.20 123 154537 98008 64246064
Incoherent 32.50 11.20 60 154600 7058 64337014
Psychomotor skills impaired 32.44 11.20 43 154617 3802 64340270
Angioedema 32.22 11.20 62 154598 61759 64282313
Alcohol use 32.15 11.20 47 154613 4555 64339517
Aspartate aminotransferase increased 32.02 11.20 433 154227 119355 64224717
Cystitis 32.00 11.20 33 154627 42642 64301430
Restless legs syndrome 31.91 11.20 102 154558 17014 64327058
Kidney infection 31.81 11.20 3 154657 17835 64326237
Encephalitis toxic 31.72 11.20 15 154645 276 64343796
High density lipoprotein decreased 31.56 11.20 43 154617 3903 64340169
Oedema peripheral 31.56 11.20 337 154323 209980 64134092
Impaired self-care 31.40 11.20 33 154627 2280 64341792
Echolalia 31.29 11.20 16 154644 351 64343721
Coronary artery disease 31.15 11.20 61 154599 60372 64283700
Derealisation 31.10 11.20 27 154633 1468 64342604
Glassy eyes 30.84 11.20 12 154648 133 64343939
Myocardial infarction 30.76 11.20 252 154408 165569 64178503
Lethargy 30.62 11.20 287 154373 72307 64271765
Night sweats 30.43 11.20 25 154635 36021 64308051
Myelodysplastic syndrome 30.40 11.20 14 154646 27565 64316507
Inappropriate affect 30.37 11.20 25 154635 1263 64342809
Dysphonia 30.33 11.20 40 154620 46342 64297730
Gastrointestinal sounds abnormal 30.32 11.20 47 154613 4796 64339276
Oral discharge 30.19 11.20 14 154646 246 64343826
Distractibility 30.18 11.20 19 154641 627 64343445
Throat tightness 30.16 11.20 9 154651 23151 64320921
Drug use disorder 30.16 11.20 53 154607 6001 64338071
Helplessness 30.10 11.20 15 154645 311 64343761
Osteonecrosis 30.10 11.20 15 154645 28214 64315858
Surgery 30.07 11.20 15 154645 28198 64315874
Sluggishness 30.03 11.20 51 154609 5619 64338453
Haemorrhage 30.02 11.20 94 154566 79257 64264815
Polydipsia psychogenic 29.89 11.20 13 154647 195 64343877
Hyperreflexia 29.85 11.20 58 154602 7090 64336982
Cerebrovascular stenosis 29.85 11.20 12 154648 146 64343926
Choreoathetosis 29.84 11.20 26 154634 1421 64342651
Dry skin 29.66 11.20 48 154612 51113 64292959
Cyclothymic disorder 29.59 11.20 13 154647 200 64343872
Dysphoria 29.48 11.20 44 154616 4344 64339728
Cerebrovascular accident 29.36 11.20 201 154459 137382 64206690
Pulmonary arterial hypertension 29.36 11.20 12 154648 25355 64318717
Localised infection 29.30 11.20 18 154642 30143 64313929
Soliloquy 29.20 11.20 18 154642 572 64343500
Bezoar 29.14 11.20 31 154629 2172 64341900
Skin discolouration 29.09 11.20 25 154635 35230 64308842
Upper gastrointestinal haemorrhage 29.03 11.20 25 154635 35195 64308877
Accidental death 28.90 11.20 40 154620 3685 64340387
Ear infection 28.88 11.20 10 154650 23394 64320678
Foot deformity 28.84 11.20 3 154657 16501 64327571
Haemophagocytic lymphohistiocytosis 28.80 11.20 4 154656 17605 64326467
Pulmonary fibrosis 28.79 11.20 18 154642 29860 64314212
Bursitis 28.63 11.20 8 154652 21477 64322595
Aspergillus infection 28.56 11.20 3 154657 16376 64327696
Physical assault 28.35 11.20 26 154634 1520 64342552
Hip arthroplasty 28.35 11.20 8 154652 21343 64322729
Hypervolaemia 28.26 11.20 30 154630 38255 64305817
Joint range of motion decreased 28.12 11.20 6 154654 19337 64324735
Cardiomyopathy 28.10 11.20 128 154532 25228 64318844
Faecaloma 28.09 11.20 68 154592 9660 64334412
Coma scale 28.08 11.20 9 154651 53 64344019
Antipsychotic drug level decreased 28.04 11.20 21 154639 923 64343149
Cold-stimulus headache 27.93 11.20 7 154653 13 64344059
Encephalitis autoimmune 27.60 11.20 28 154632 1856 64342216
Alcohol abuse 27.51 11.20 45 154615 4807 64339265
Wrong technique in product usage process 27.48 11.20 73 154587 64901 64279171
Refusal of examination 27.45 11.20 10 154650 91 64343981
Dysphagia 27.29 11.20 383 154277 106429 64237643
Hepatocellular injury 27.28 11.20 194 154466 45041 64299031
Hot flush 27.16 11.20 43 154617 46192 64297880
Morose 27.10 11.20 8 154652 34 64344038
Thirst 27.05 11.20 85 154575 14052 64330020
Akinesia 26.85 11.20 35 154625 3044 64341028
Product substitution issue 26.79 11.20 99 154561 17762 64326310
Asocial behaviour 26.76 11.20 9 154651 63 64344009
Phagophobia 26.73 11.20 8 154652 36 64344036
Procedural pain 26.64 11.20 3 154657 15505 64328567
Urinary incontinence 26.63 11.20 163 154497 35988 64308084
Peptostreptococcus infection 26.52 11.20 9 154651 65 64344007
Somatic hallucination 26.38 11.20 8 154652 38 64344034
Resting tremor 26.36 11.20 24 154636 1390 64342682
Hypercholesterolaemia 26.32 11.20 89 154571 15284 64328788
Hyperbilirubinaemia 26.27 11.20 9 154651 21196 64322876
Candida infection 26.27 11.20 22 154638 31397 64312675
Tendonitis 26.20 11.20 8 154652 20274 64323798
Symptom recurrence 26.13 11.20 20 154640 909 64343163
Abnormal clotting factor 26.10 11.20 10 154650 106 64343966
Plasma cell myeloma 25.99 11.20 44 154616 46031 64298041
Body mass index increased 25.98 11.20 25 154635 1554 64342518
Anger 25.96 11.20 90 154570 15651 64328421
Hypometabolism 25.94 11.20 9 154651 70 64344002
Progressive multifocal leukoencephalopathy 25.81 11.20 6 154654 18226 64325846
Bronchopulmonary aspergillosis 25.63 11.20 7 154653 19078 64324994
Exhibitionism 25.57 11.20 8 154652 43 64344029
Dysgeusia 25.56 11.20 46 154614 47001 64297071
Pulmonary hypertension 25.45 11.20 40 154620 43099 64300973
Drug abuser 25.33 11.20 48 154612 5760 64338312
Drug level above therapeutic 25.25 11.20 53 154607 6848 64337224
Prostate cancer 25.23 11.20 8 154652 19787 64324285
Glutamate dehydrogenase increased 25.12 11.20 7 154653 23 64344049
Perseveration 25.09 11.20 14 154646 368 64343704
Disease recurrence 25.09 11.20 145 154515 31365 64312707
Septic shock 25.08 11.20 149 154511 105288 64238784
Affect lability 25.06 11.20 62 154598 8928 64335144
Reduced facial expression 24.94 11.20 28 154632 2085 64341987
Antisocial behaviour 24.91 11.20 16 154644 547 64343525
Bone disorder 24.77 11.20 5 154655 16754 64327318
Pharyngeal dystonia 24.74 11.20 6 154654 9 64344063
Hyperlipidaemia 24.73 11.20 115 154545 22861 64321211
Exposure during pregnancy 24.69 11.20 290 154370 77385 64266687
Hypomagnesaemia 24.68 11.20 32 154628 37344 64306728
Device dislocation 24.54 11.20 10 154650 21168 64322904
Personality disorder 24.45 11.20 42 154618 4669 64339403
Pancreatitis haemorrhagic 24.35 11.20 16 154644 569 64343503
Rectal haemorrhage 24.26 11.20 72 154588 61745 64282327
Febrile neutropenia 24.16 11.20 311 154349 187346 64156726
Xanthoma 24.10 11.20 11 154649 186 64343886
Full blood count decreased 24.07 11.20 12 154648 22570 64321502
Frequent bowel movements 24.05 11.20 7 154653 18298 64325774
Hepatitis C virus test positive 24.00 11.20 13 154647 322 64343750
Dissociative disorder 23.82 11.20 14 154646 407 64343665
Oral candidiasis 23.76 11.20 13 154647 23199 64320873
Device related infection 23.74 11.20 23 154637 30603 64313469
Hypersomnia 23.72 11.20 102 154558 19615 64324457
Haematoma 23.57 11.20 47 154613 46203 64297869
Myelosuppression 23.46 11.20 14 154646 23816 64320256
Patient restraint 23.44 11.20 9 154651 96 64343976
Personality change due to a general medical condition 23.36 11.20 10 154650 144 64343928
Psychotic disorder due to a general medical condition 23.23 11.20 12 154648 269 64343803
Neurodegenerative disorder 23.19 11.20 14 154646 428 64343644
Metastases to bone 23.11 11.20 10 154650 20425 64323647
Palmar-plantar erythrodysaesthesia syndrome 23.10 11.20 21 154639 28798 64315274
Squamous cell carcinoma 23.04 11.20 3 154657 13866 64330206
Blood pressure systolic increased 22.91 11.20 53 154607 49400 64294672
Clostridium difficile colitis 22.83 11.20 19 154641 27204 64316868
Total cholesterol/HDL ratio increased 22.71 11.20 11 154649 214 64343858
Stress 22.69 11.20 72 154588 60462 64283610
Loss of personal independence in daily activities 22.64 11.20 93 154567 72361 64271711
Palpitations 22.62 11.20 152 154508 104336 64239736
Thrombotic microangiopathy 22.57 11.20 6 154654 16649 64327423
Gastric disorder 22.55 11.20 22 154638 29175 64314897
Somatic symptom disorder 22.47 11.20 25 154635 1843 64342229
Sexually inappropriate behaviour 22.46 11.20 14 154646 454 64343618
Psychotic behaviour 22.25 11.20 19 154641 1010 64343062
Osteomyelitis 22.23 11.20 20 154640 27567 64316505
Osteopenia 22.22 11.20 5 154655 15535 64328537
Multiple organ dysfunction syndrome 22.21 11.20 147 154513 101266 64242806
Joint effusion 22.18 11.20 3 154657 13470 64330602
Electrocardiogram abnormal 22.16 11.20 77 154583 13404 64330668
Staphylococcal infection 22.15 11.20 56 154604 50622 64293450
Oral pain 22.08 11.20 20 154640 27473 64316599
Myoglobin blood increased 22.07 11.20 30 154630 2717 64341355
Electrocardiogram T wave inversion 22.03 11.20 41 154619 4853 64339219
Right ventricular failure 22.01 11.20 12 154648 21459 64322613
Hunger 22.00 11.20 38 154622 4243 64339829
Ulcer 21.94 11.20 14 154646 22976 64321096
Rash macular 21.83 11.20 15 154645 23670 64320402
Antiphospholipid antibodies 21.71 11.20 9 154651 119 64343953
Tic 21.65 11.20 29 154631 2590 64341482
Judgement impaired 21.56 11.20 19 154641 1054 64343018
Faeces discoloured 21.53 11.20 18 154642 25711 64318361
Immunodeficiency 21.49 11.20 6 154654 16118 64327954
Wrong patient received product 21.48 11.20 35 154625 3727 64340345
Illness 21.44 11.20 13 154647 21925 64322147
Injury 21.41 11.20 66 154594 55926 64288146
Adrenal insufficiency 21.05 11.20 14 154646 22473 64321599
Anxiolytic therapy 21.02 11.20 6 154654 22 64344050
Drug therapy enhancement 21.02 11.20 6 154654 22 64344050
Blood ketone body 21.00 11.20 9 154651 130 64343942
Pneumonitis 20.99 11.20 57 154603 50308 64293764
Haemoglobin decreased 20.98 11.20 335 154325 194728 64149344
Pancytopenia 20.93 11.20 231 154429 143078 64200994
Delusional perception 20.89 11.20 12 154648 334 64343738
Tachyphrenia 20.68 11.20 24 154636 1852 64342220
Hostility 20.68 11.20 26 154634 2181 64341891
Electrocardiogram J wave abnormal 20.42 11.20 5 154655 8 64344064
Lip swelling 20.37 11.20 28 154632 31879 64312193
Foot fracture 20.35 11.20 9 154651 18148 64325924
Rash erythematous 20.29 11.20 55 154605 48578 64295494
Oedema 20.27 11.20 133 154527 91802 64252270
Tongue biting 20.22 11.20 23 154637 1737 64342335
Visual impairment 20.20 11.20 100 154560 73977 64270095
Negative thoughts 20.06 11.20 20 154640 1298 64342774
Tenderness 20.03 11.20 11 154649 19591 64324481
Gastrooesophageal reflux disease 20.03 11.20 117 154543 83026 64261046
Bacteraemia 19.96 11.20 21 154639 26890 64317182
Blood pressure fluctuation 19.93 11.20 61 154599 51810 64292262
Vomiting 19.86 11.20 1100 153560 550017 63794055
Incontinence 19.86 11.20 69 154591 12012 64332060
Drug screen positive 19.81 11.20 43 154617 5686 64338386
Respiratory tract congestion 19.78 11.20 7 154653 16158 64327914
Neoplasm malignant 19.78 11.20 18 154642 24670 64319402
Metastases to lung 19.75 11.20 6 154654 15258 64328814
Skin reaction 19.75 11.20 3 154657 12349 64331723
Disorganised speech 19.70 11.20 22 154638 1628 64342444
Tobacco interaction 19.68 11.20 7 154653 59 64344013
Acute myocardial infarction 19.65 11.20 93 154567 69625 64274447
Blood cholesterol abnormal 19.63 11.20 28 154632 2653 64341419
Homicidal ideation 19.55 11.20 31 154629 3226 64340846
Skin lesion 19.52 11.20 36 154624 36446 64307626
Therapy interrupted 19.40 11.20 12 154648 20024 64324048
Ear pain 19.34 11.20 19 154641 25117 64318955
Haemoptysis 19.34 11.20 57 154603 48991 64295081
Flight of ideas 19.32 11.20 15 154645 696 64343376
Abdominal pain lower 19.25 11.20 21 154639 26448 64317624
Mouth ulceration 19.22 11.20 30 154630 32414 64311658
Full blood count abnormal 19.11 11.20 26 154634 29731 64314341
Panic attack 19.08 11.20 100 154560 20853 64323219
Cerebral atrophy 19.01 11.20 49 154611 7236 64336836
Colitis ischaemic 19 11.20 73 154587 13341 64330731
Paradoxical drug reaction 18.99 11.20 44 154616 6076 64337996
Delusional disorder, erotomanic type 18.91 11.20 6 154654 34 64344038
Lung disorder 18.91 11.20 78 154582 60622 64283450
Femur fracture 18.88 11.20 33 154627 34102 64309970
Apallic syndrome 18.86 11.20 16 154644 843 64343229
Gambling disorder 18.85 11.20 23 154637 1871 64342201
Illness anxiety disorder 18.82 11.20 10 154650 238 64343834
Blood pressure diastolic abnormal 18.82 11.20 3 154657 11914 64332158
Arrhythmia 18.79 11.20 202 154458 52742 64291330
Breast discomfort 18.65 11.20 11 154649 322 64343750
Blood glucose 18.49 11.20 6 154654 37 64344035
Consciousness fluctuating 18.48 11.20 21 154639 1584 64342488
Drop attacks 18.48 11.20 17 154643 998 64343074
Selective mutism 18.46 11.20 7 154653 72 64344000
Tachypnoea 18.45 11.20 118 154542 26453 64317619
Hyperosmolar state 18.43 11.20 14 154646 629 64343443
Hypotonia 18.40 11.20 64 154596 11148 64332924
Rash papular 18.38 11.20 9 154651 17104 64326968
Tumour lysis syndrome 18.33 11.20 12 154648 19428 64324644
Psychogenic visual disorder 18.28 11.20 5 154655 15 64344057
Heart rate decreased 18.27 11.20 69 154591 54998 64289074
Compulsions 18.26 11.20 11 154649 335 64343737
Hypersexuality 18.14 11.20 20 154640 1459 64342613
Haemoglobin urine 18.10 11.20 8 154652 125 64343947
Differential white blood cell count abnormal 18.05 11.20 22 154638 1788 64342284
Parkinsonian rest tremor 17.95 11.20 10 154650 262 64343810
Injection site haemorrhage 17.95 11.20 19 154641 24259 64319813
Blood thrombin increased 17.91 11.20 4 154656 3 64344069
Inferiority complex 17.91 11.20 4 154656 3 64344069
Skin necrosis 17.89 11.20 6 154654 14323 64329749
Communication disorder 17.89 11.20 32 154628 3674 64340398
Lymphadenopathy 17.87 11.20 55 154605 46631 64297441
Gastric ulcer 17.87 11.20 28 154632 30206 64313866
Brain oedema 17.85 11.20 102 154558 21973 64322099
Symptom masked 17.83 11.20 18 154642 1186 64342886
Limb injury 17.82 11.20 18 154642 23487 64320585
Deafness 17.77 11.20 11 154649 18348 64325724
Flatulence 17.53 11.20 37 154623 35629 64308443
Coagulopathy 17.53 11.20 31 154629 31889 64312183
Slow speech 17.52 11.20 23 154637 2014 64342058
Bronchiectasis 17.52 11.20 6 154654 14134 64329938
Haemorrhoids 17.50 11.20 19 154641 23982 64320090
Electrocardiogram QT interval abnormal 17.39 11.20 10 154650 279 64343793
Viral infection 17.34 11.20 38 154622 36102 64307970
Saccadic eye movement 17.33 11.20 8 154652 139 64343933
Swelling face 17.23 11.20 78 154582 59088 64284984
Alcoholism 17.13 11.20 30 154630 3387 64340685
Musculoskeletal disorder 16.96 11.20 11 154649 17895 64326177
Respiratory dyskinesia 16.93 11.20 6 154654 50 64344022
Pseudomonas infection 16.92 11.20 11 154649 17872 64326200
Meige's syndrome 16.91 11.20 4 154656 5 64344067
Monocyte count decreased 16.88 11.20 27 154633 2830 64341242
Protrusion tongue 16.87 11.20 11 154649 386 64343686
Tubo-ovarian abscess 16.86 11.20 10 154650 296 64343776
Skin cancer 16.83 11.20 4 154656 11970 64332102
Benign ethnic neutropenia 16.83 11.20 6 154654 51 64344021
Secretion discharge 16.81 11.20 4 154656 11960 64332112
Tooth infection 16.75 11.20 7 154653 14594 64329478
Ideas of reference 16.64 11.20 8 154652 153 64343919
Drug level decreased 16.62 11.20 63 154597 11440 64332632
Extrasystoles 16.57 11.20 44 154616 6614 64337458
Pancreatitis 16.55 11.20 217 154443 59390 64284682
Self-medication 16.54 11.20 33 154627 4112 64339960
Extensor plantar response 16.46 11.20 20 154640 1620 64342452
Uveitis 16.44 11.20 5 154655 12703 64331369
Blood creatine phosphokinase decreased 16.42 11.20 14 154646 743 64343329
Troponin T increased 16.39 11.20 24 154636 2329 64341743
Substance use 16.31 11.20 13 154647 627 64343445
Breast cancer 16.29 11.20 28 154632 29120 64314952
Poverty of thought content 16.24 11.20 6 154654 57 64344015
Breast enlargement 16.21 11.20 18 154642 1324 64342748
Obstructive airways disorder 16.20 11.20 19 154641 23166 64320906
Low density lipoprotein increased 16.17 11.20 48 154612 7692 64336380
Dissociative identity disorder 16.15 11.20 6 154654 58 64344014
Illiteracy 16.12 11.20 5 154655 26 64344046
Lactic acidosis 16.11 11.20 84 154576 61326 64282746
Pathogen resistance 16.11 11.20 5 154655 12538 64331534
Paraphilia 16.06 11.20 6 154654 59 64344013
Skin infection 16.01 11.20 8 154652 15029 64329043
Myocardial reperfusion injury 15.96 11.20 5 154655 27 64344045
Dizziness 15.95 11.20 856 153804 429307 63914765
Cerebellar atrophy 15.88 11.20 16 154644 1052 64343020
Joint injury 15.83 11.20 19 154641 22928 64321144
Echopraxia 15.81 11.20 5 154655 28 64344044
Troponin increased 15.79 11.20 76 154584 15323 64328749
Opisthotonus 15.77 11.20 13 154647 658 64343414
Myocardial hypoxia 15.77 11.20 4 154656 8 64344064
Blood osmolarity increased 15.76 11.20 12 154648 541 64343531
Exostosis 15.73 11.20 4 154656 11434 64332638
Postictal paralysis 15.70 11.20 10 154650 337 64343735
Glycosylated haemoglobin increased 15.67 11.20 78 154582 15941 64328131
Prolactin-producing pituitary tumour 15.57 11.20 7 154653 114 64343958
Abscess 15.55 11.20 14 154646 19290 64324782
Paraesthesia oral 15.54 11.20 6 154654 13125 64330947
Spinal compression fracture 15.53 11.20 8 154652 14767 64329305
Tricuspid valve sclerosis 15.52 11.20 5 154655 30 64344042
Cerebellar syndrome 15.50 11.20 36 154624 4980 64339092
Pharyngeal oedema 15.46 11.20 9 154651 15522 64328550
Movement disorder 15.46 11.20 98 154562 21902 64322170
Constricted affect 15.45 11.20 4 154656 9 64344063
Tubulointerstitial nephritis 15.25 11.20 32 154628 30877 64313195
Ageusia 15.24 11.20 7 154653 13806 64330266
Rotator cuff syndrome 15.24 11.20 5 154655 12102 64331970
Wrong patient 15.22 11.20 8 154652 186 64343886
Antidepressant drug level increased 15.11 11.20 10 154650 360 64343712
Inborn error of metabolism 15.11 11.20 3 154657 0 64344072
Psychiatric evaluation abnormal 15.11 11.20 3 154657 0 64344072
Pseudogynaecomastia 15.11 11.20 3 154657 0 64344072
Skin disorder 15.09 11.20 27 154633 27653 64316419
Obsessive-compulsive personality disorder 15.09 11.20 7 154653 123 64343949
Circadian rhythm sleep disorder 15.04 11.20 12 154648 580 64343492
Excessive masturbation 15.00 11.20 6 154654 72 64344000
Tooth disorder 14.98 11.20 19 154641 22383 64321689
Sneezing 14.95 11.20 9 154651 15242 64328830
Dyspraxia 14.94 11.20 9 154651 274 64343798
Feelings of worthlessness 14.86 11.20 11 154649 475 64343597
Chorea 14.81 11.20 21 154639 1979 64342093
Bladder cancer 14.78 11.20 4 154656 10970 64333102
Oxygen saturation decreased 14.77 11.20 175 154485 107001 64237071
Ketosis-prone diabetes mellitus 14.63 11.20 4 154656 12 64344060
Mixed delusion 14.63 11.20 4 154656 12 64344060
Off label use 14.57 11.20 1313 153347 631493 63712579
Muscle contractions involuntary 14.54 11.20 27 154633 3190 64340882
Drowning 14.53 11.20 13 154647 736 64343336
Renal tubular necrosis 14.52 11.20 19 154641 22091 64321981
Organic erectile dysfunction 14.50 11.20 6 154654 79 64343993
Agitated depression 14.49 11.20 9 154651 290 64343782
Grip strength decreased 14.48 11.20 5 154655 11719 64332353
Gastroenteritis 14.45 11.20 31 154629 29680 64314392
Neutrophilia 14.45 11.20 42 154618 6652 64337420
Drug ineffective 14.43 11.20 2259 152401 837988 63506084
Thyroid disorder 14.42 11.20 5 154655 11687 64332385
Libido decreased 14.41 11.20 34 154626 4750 64339322
Congestive cardiomyopathy 14.41 11.20 56 154604 10288 64333784
Premature delivery 14.36 11.20 14 154646 18575 64325497
Product storage error 14.31 11.20 7 154653 13311 64330761
Proteinuria 14.27 11.20 28 154632 27695 64316377
Fear 14.26 11.20 90 154570 20081 64323991
Anterograde amnesia 14.21 11.20 12 154648 628 64343444
Muscle twitching 14.21 11.20 86 154574 18912 64325160
Pica 14.18 11.20 5 154655 41 64344031
Pupillary reflex impaired 14.15 11.20 26 154634 3047 64341025
Neglect of personal appearance 14.10 11.20 7 154653 144 64343928
Toxic epidermal necrolysis 14.07 11.20 44 154616 37122 64306950
Tangentiality 14.01 11.20 7 154653 146 64343926
Enthesopathy 13.99 11.20 3 154657 9635 64334437
Slow response to stimuli 13.98 11.20 18 154642 1547 64342525
Lacrimation increased 13.97 11.20 14 154646 18332 64325740
Secondary tic 13.95 11.20 4 154656 15 64344057
Disseminated intravascular coagulation 13.94 11.20 36 154624 32312 64311760
Sinus disorder 13.94 11.20 12 154648 16896 64327176
Product packaging confusion 13.92 11.20 8 154652 223 64343849
Cerebral haemorrhage 13.91 11.20 69 154591 51021 64293051
Pneumothorax 13.89 11.20 23 154637 24275 64319797
Bundle branch block right 13.83 11.20 55 154605 10214 64333858
Blood pressure diastolic decreased 13.81 11.20 20 154640 22281 64321791
End stage renal disease 13.77 11.20 4 154656 10471 64333601
Graft versus host disease 13.76 11.20 8 154652 13805 64330267
Schizophreniform disorder 13.75 11.20 7 154653 152 64343920
Shock haemorrhagic 13.74 11.20 12 154648 16779 64327293
Wrong drug 13.69 11.20 8 154652 230 64343842
Tongue movement disturbance 13.65 11.20 9 154651 322 64343750
Granulocyte count decreased 13.53 11.20 16 154644 1260 64342812
Staphylococcal bacteraemia 13.53 11.20 4 154656 10351 64333721
Skin fissures 13.43 11.20 4 154656 10302 64333770
Cyst 13.42 11.20 6 154654 12021 64332051
Transfusion 13.39 11.20 14 154646 17980 64326092
Injection site mass 13.35 11.20 13 154647 17257 64326815
Chemical poisoning 13.35 11.20 7 154653 162 64343910
Coordination abnormal 13.34 11.20 71 154589 14893 64329179
Nodule 13.32 11.20 14 154646 17933 64326139
Complication associated with device 13.31 11.20 10 154650 15070 64329002
Floppy iris syndrome 13.31 11.20 9 154651 336 64343736
Salivary gland calculus 13.27 11.20 8 154652 244 64343828
Affective ambivalence 13.19 11.20 4 154656 19 64344053
Increased tendency to bruise 13.19 11.20 3 154657 9252 64334820
Sputum discoloured 13.17 11.20 14 154646 17842 64326230
Confabulation 13.17 11.20 10 154650 449 64343623
Parkinsonian gait 13.14 11.20 13 154647 836 64343236
Ventricular tachyarrhythmia 13.10 11.20 8 154652 250 64343822
Lymphocyte count 13.03 11.20 3 154657 3 64344069
Eye pain 13.02 11.20 36 154624 31589 64312483
Coprolalia 12.97 11.20 5 154655 54 64344018
Posturing 12.96 11.20 14 154646 998 64343074
Immune system disorder 12.95 11.20 3 154657 9138 64334934
Eosinophil count abnormal 12.94 11.20 11 154649 581 64343491
Gastroenteritis viral 12.91 11.20 17 154643 19712 64324360
Alcohol problem 12.89 11.20 5 154655 55 64344017
Clostridium difficile infection 12.87 11.20 44 154616 36119 64307953
Nephrogenic diabetes insipidus 12.79 11.20 19 154641 1868 64342204
Angina unstable 12.72 11.20 11 154649 15456 64328616
Drug dependence 12.72 11.20 129 154531 33183 64310889
Pharyngeal dyskinesia 12.71 11.20 4 154656 22 64344050
Eosinophilic pleural effusion 12.68 11.20 8 154652 265 64343807
Globulins decreased 12.65 11.20 9 154651 365 64343707
Fluid intake restriction 12.65 11.20 5 154655 58 64344014
Device occlusion 12.64 11.20 4 154656 9909 64334163
Poor venous access 12.64 11.20 7 154653 12410 64331662
Pituitary tumour benign 12.64 11.20 21 154639 2272 64341800
Vascular stenosis 12.59 11.20 10 154650 480 64343592
Electrocardiogram J wave 12.57 11.20 5 154655 59 64344013
Neuroleptic-induced deficit syndrome 12.56 11.20 4 154656 23 64344049
Musculoskeletal stiffness 12.45 11.20 214 154446 122992 64221080
Troponin I increased 12.44 11.20 28 154632 3793 64340279
Gun shot wound 12.39 11.20 14 154646 1050 64343022
Dermatitis 12.36 11.20 15 154645 18014 64326058
Fistula 12.34 11.20 4 154656 9757 64334315
Respiratory tract infection 12.33 11.20 47 154613 37360 64306712
Panic disorder 12.29 11.20 23 154637 2734 64341338
Gaze palsy 12.28 11.20 22 154638 2528 64341544
Blood urea decreased 12.21 11.20 23 154637 2748 64341324
Breathing-related sleep disorder 12.18 11.20 7 154653 195 64343877
Creatinine renal clearance decreased 12.18 11.20 10 154650 14411 64329661
Product measured potency issue 12.15 11.20 7 154653 196 64343876
Circulatory collapse 12.11 11.20 129 154531 33603 64310469
Spinal disorder 12.09 11.20 3 154657 8719 64335353
Anticonvulsant drug level increased 12.09 11.20 21 154639 2356 64341716
Sedation complication 12.02 11.20 53 154607 10301 64333771
Brief psychotic disorder, with postpartum onset 12.02 11.20 4 154656 27 64344045
Dependent personality disorder 12.01 11.20 6 154654 125 64343947
Sinus bradycardia 12.00 11.20 95 154565 22798 64321274
Paternal exposure timing unspecified 12.00 11.20 5 154655 67 64344005
Frontotemporal dementia 12.00 11.20 10 154650 514 64343558
Acquired haemophilia 11.98 11.20 17 154643 1603 64342469
Glucocorticoids increased 11.97 11.20 6 154654 126 64343946
Dry eye 11.97 11.20 33 154627 28986 64315086
Intestinal pseudo-obstruction 11.95 11.20 19 154641 1981 64342091
Pulmonary valve incompetence 11.93 11.20 17 154643 1609 64342463
Pulmonary congestion 11.93 11.20 98 154562 23782 64320290
Hernia 11.88 11.20 9 154651 13509 64330563
Blood chloride decreased 11.88 11.20 42 154618 7374 64336698
Live birth 11.87 11.20 6 154654 11198 64332874
Postoperative wound infection 11.78 11.20 5 154655 10331 64333741
Intestinal infarction 11.77 11.20 15 154645 1276 64342796
Terminal insomnia 11.76 11.20 13 154647 951 64343121
Menstruation irregular 11.75 11.20 30 154630 4405 64339667
Intervertebral disc protrusion 11.65 11.20 19 154641 20172 64323900
Abdominal distension 11.65 11.20 161 154499 95833 64248239
Spinal pain 11.62 11.20 8 154652 12613 64331459
Hyperthermia malignant 11.57 11.20 21 154639 2438 64341634
Motor dysfunction 11.57 11.20 56 154604 11317 64332755
Ovarian cyst 11.53 11.20 6 154654 11012 64333060
Lymphocyte count increased 11.51 11.20 32 154628 4943 64339129
Respiratory disorder 11.50 11.20 46 154614 36065 64308007
Neuroglycopenia 11.50 11.20 5 154655 75 64343997
Inappropriate schedule of product administration 11.48 11.20 154 154506 92132 64251940
Myotonia 11.40 11.20 7 154653 221 64343851
Hypoventilation 11.39 11.20 36 154624 5970 64338102
Gait disturbance 11.31 11.20 513 154147 171642 64172430
Autoimmune hepatitis 11.30 11.20 5 154655 10079 64333993
Bilirubin urine present 11.30 11.20 8 154652 322 64343750
Mass 11.24 11.20 12 154648 15264 64328808
Enterococcal infection 11.24 11.20 10 154650 13856 64330216
Cyanosis central 11.23 11.20 7 154653 227 64343845

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 33.88 28.61 40 465 1283 82890

Pharmacologic Action:

SourceCodeDescription
ATC N05AH03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:65191 atypical antipsychotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Major depressive disorder indication 370143000
Depression Treatment Adjunct indication
Agitation associated with Bipolar Mania indication
Agitation associated with Schizophrenia indication
Nausea and vomiting off-label use 16932000
Feeling agitated off-label use 24199005
Migraine off-label use 37796009 DOID:6364
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Chemotherapy-induced nausea and vomiting off-label use 236084000
cannabinoid hyperememsis off-label use 11047881000119100
cannabinoid hyperememsis off-label use 11048011000119100
Delirium contraindication 2776000
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Sedation contraindication 72641008
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.72 Basic
pKa3 0.66 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.32 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.52 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
D(1A) dopamine receptor GPCR Ki 7.40 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.49 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.74 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 6.26 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Kd 5.90 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 7.92 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.98 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.72 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.09 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.10 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.16 WOMBAT-PK
Histamine H2 receptor GPCR Ki 7.36 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.51 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.10 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.14 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 6.12 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.54 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 7.59 DRUG MATRIX
5-hydroxytryptamine receptor 3A Ion channel Ki 6.70 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.92 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.70 IUPHAR
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 6.43 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 7.68 WOMBAT-PK
Histone H1.0 Nuclear other Ki 8.70 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 8.05 WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 5.56 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.68 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.36 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.19 CHEMBL
Histamine H1 receptor GPCR Ki 8.20 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.66 CHEMBL
D(2) dopamine receptor GPCR Ki 7.90 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.40 CHEMBL
Transporter Transporter Ki 6.02 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 9.52 CHEMBL
D(3) dopamine receptor GPCR Ki 7.41 CHEMBL
D(4) dopamine receptor GPCR Ki 7.30 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.60 IUPHAR
Transporter Transporter Ki 5.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.54 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.92 CHEMBL

External reference:

IDSource
4020996 VUID
N0000148465 NUI
D00454 KEGG_DRUG
221373-18-8 SECONDARY_CAS_RN
4020996 VANDF
C0171023 UMLSCUI
CHEBI:7735 CHEBI
CHEMBL715 ChEMBL_ID
CHEMBL1201741 ChEMBL_ID
CHEMBL3989694 ChEMBL_ID
DB00334 DRUGBANK_ID
D000077152 MESH_DESCRIPTOR_UI
135398745 PUBCHEM_CID
47 IUPHAR_LIGAND_ID
6956 INN_ID
N7U69T4SZR UNII
1294588 RXNORM
169390 MMSL
172501 MMSL
5198 MMSL
6063 MMSL
d04050 MMSL
006204 NDDF
013309 NDDF
108441004 SNOMEDCT_US
386849001 SNOMEDCT_US
725800004 SNOMEDCT_US
735189005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 3 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 6 mg ORAL NDA 34 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4456 TABLET, ORALLY DISINTEGRATING 20 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4456 TABLET, ORALLY DISINTEGRATING 20 mg ORAL NDA 36 sections
ZYPREXA Intramuscular HUMAN PRESCRIPTION DRUG LABEL 1 0002-7597 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR NDA 36 sections
ZYPREXA Intramuscular HUMAN PRESCRIPTION DRUG LABEL 1 0002-7597 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR NDA 36 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5245 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5245 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5246 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5246 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5247 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5247 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 31 sections