olanzapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1982 132539-06-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • olanzapine pamoate
  • olanzapine embonate
  • zyprexa relprevv
  • olanzapine pamoate monohydrate
  • olanzapine
  • zyprexa
  • LY 170053
  • LY-170053
The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown.
  • Molecular weight: 312.44
  • Formula: C17H20N4S
  • CLOGP: 2.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.52
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 27, 1996 EMA Eli Lilly Nederland B.V.
Sept. 30, 1996 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1591.83 11.92 638 104877 11418 63372089
Suicide attempt 1304.19 11.92 960 104555 59958 63323549
Sedation 1186.42 11.92 762 104753 38047 63345460
Intentional overdose 995.67 11.92 890 104625 73262 63310245
Extrapyramidal disorder 893.50 11.92 438 105077 12846 63370661
Dystonia 891.88 11.92 443 105072 13376 63370131
Sexual dysfunction 877.21 11.92 314 105201 4045 63379462
Blood prolactin abnormal 870.18 11.92 286 105229 2793 63380714
Akathisia 804.61 11.92 363 105152 8783 63374724
Sopor 774.70 11.92 474 105041 21690 63361817
Anosognosia 749.45 11.92 258 105257 2938 63380569
Electrocardiogram QT prolonged 713.99 11.92 671 104844 58859 63324648
Intentional self-injury 703.38 11.92 471 105044 25216 63358291
Disturbance in social behaviour 675.06 11.92 253 105262 3740 63379767
Metabolic disorder 658.75 11.92 285 105230 6218 63377289
Agitation 625.30 11.92 625 104890 59132 63324375
Schizophrenia 612.57 11.92 309 105206 9643 63373864
Psychotic disorder 603.93 11.92 429 105086 25283 63358224
Toxicity to various agents 603.84 11.92 1293 104222 245957 63137550
Dyskinesia 601.58 11.92 467 105048 31535 63351972
Drug interaction 592.87 11.92 1227 104288 227904 63155603
Overdose 560.98 11.92 816 104699 114262 63269245
Hyperprolactinaemia 555.08 11.92 218 105297 3682 63379825
Drug abuse 528.74 11.92 627 104888 71891 63311616
Personality change 520.51 11.92 247 105268 6726 63376781
Somnolence 519.58 11.92 1005 104510 177680 63205827
Delusion 508.91 11.92 291 105224 11726 63371781
Arthralgia 503.52 11.92 161 105354 569549 62813958
Pain 496.09 11.92 311 105204 740317 62643190
Completed suicide 493.27 11.92 875 104640 144798 63238709
Hallucination, auditory 491.34 11.92 291 105224 12533 63370974
Catatonia 449.49 11.92 195 105320 4282 63379225
Post-injection delirium sedation syndrome 440.37 11.92 86 105429 28 63383479
Parkinsonism 434.59 11.92 250 105265 10189 63373318
Weight increased 403.15 11.92 1145 104370 259647 63123860
Mania 370.61 11.92 240 105275 12127 63371380
Diabetes mellitus 368.38 11.92 459 105056 55351 63328156
Schizoaffective disorder 357.12 11.92 155 105360 3407 63380100
Tardive dyskinesia 352.28 11.92 203 105312 8299 63375208
Metabolic syndrome 352.24 11.92 123 105392 1465 63382042
Coma 351.24 11.92 482 105033 63882 63319625
Rheumatoid arthritis 344.70 11.92 19 105496 253800 63129707
Suicidal ideation 333.93 11.92 463 105052 61958 63321549
Arthropathy 330.30 11.92 14 105501 234778 63148729
Salivary hypersecretion 325.54 11.92 186 105329 7480 63376027
Aggression 322.79 11.92 286 105229 23212 63360295
Hypomania 322.05 11.92 173 105342 6157 63377350
Joint swelling 319.94 11.92 76 105439 327590 63055917
Muscle rigidity 319.83 11.92 213 105302 11287 63372220
Pleurothotonus 316.65 11.92 109 105406 1240 63382267
Depressed level of consciousness 309.18 11.92 445 105070 61633 63321874
Infusion related reaction 297.82 11.92 31 105484 245490 63138017
Abdominal discomfort 284.09 11.92 90 105425 320795 63062712
Hypersensitivity 279.61 11.92 71 105444 292614 63090893
Tachycardia 277.46 11.92 609 104906 117547 63265960
Fatigue 275.10 11.92 676 104839 887352 62496155
Contraindicated product administered 273.15 11.92 24 105491 217624 63165883
Swelling 270.47 11.92 63 105452 275315 63108192
Restlessness 269.84 11.92 287 105228 29166 63354341
Hypothermia 267.83 11.92 204 105311 13377 63370130
Rash 249.89 11.92 341 105174 560530 62822977
Sinusitis 247.52 11.92 40 105475 226613 63156894
Blood prolactin increased 245.97 11.92 119 105396 3384 63380123
Hallucination 245.67 11.92 374 105141 54443 63329064
Headache 244.84 11.92 424 105091 632817 62750690
Alopecia 244.72 11.92 128 105387 337408 63046099
Psychomotor hyperactivity 241.30 11.92 174 105341 10489 63373018
Glossodynia 240.88 11.92 14 105501 178862 63204645
Delirium 232.41 11.92 349 105166 50192 63333315
Treatment noncompliance 231.99 11.92 298 105217 37027 63346480
Blood glucose increased 227.15 11.92 458 105057 83298 63300209
Drug hypersensitivity 223.44 11.92 119 105396 310568 63072939
Drug intolerance 219.38 11.92 120 105395 308541 63074966
Nasopharyngitis 213.33 11.92 78 105437 254179 63129328
Pruritus 213.23 11.92 173 105342 361280 63022227
Systemic lupus erythematosus 210.70 11.92 45 105470 208873 63174634
Dyspnoea 209.37 11.92 497 105018 660816 62722691
Abnormal behaviour 209.14 11.92 216 105299 21210 63362297
Tremor 206.17 11.92 583 104932 131656 63251851
Drug level increased 200.25 11.92 217 105298 22519 63360988
Persecutory delusion 196.56 11.92 95 105420 2695 63380812
Orthostatic hypertension 195.53 11.92 60 105455 458 63383049
Gestational diabetes 194.55 11.92 139 105376 8257 63375250
Peripheral swelling 193.93 11.92 100 105415 265842 63117665
Diarrhoea 192.21 11.92 583 104932 714783 62668724
Miosis 192.03 11.92 131 105384 7222 63376285
Oculogyric crisis 186.05 11.92 79 105436 1642 63381865
Pain in extremity 180.54 11.92 171 105344 331315 63052192
Galactorrhoea 174.23 11.92 100 105415 4055 63379452
Discomfort 170.90 11.92 35 105480 167339 63216168
Paranoia 170.11 11.92 147 105368 11532 63371975
Psychotic symptom 169.90 11.92 72 105443 1489 63382018
Social avoidant behaviour 167.11 11.92 87 105428 2901 63380606
Blood creatine phosphokinase increased 163.07 11.92 226 105289 30204 63353303
Jaundice cholestatic 162.27 11.92 118 105397 7206 63376301
Rhabdomyolysis 157.53 11.92 271 105244 43680 63339827
Back pain 154.94 11.92 127 105388 264018 63119489
Therapeutic product effect decreased 154.16 11.92 64 105451 193123 63190384
Psychiatric decompensation 150.42 11.92 64 105451 1337 63382170
Camptocormia 147.91 11.92 43 105472 266 63383241
Injection site pain 145.98 11.92 21 105494 129779 63253728
Antipsychotic drug level increased 144.92 11.92 83 105432 3352 63380155
Hyperthermia 141.02 11.92 119 105396 9037 63374470
Urticaria 137.08 11.92 52 105463 165750 63217757
Posture abnormal 136.46 11.92 70 105445 2262 63381245
Bradyphrenia 135.75 11.92 104 105411 6876 63376631
Serotonin syndrome 134.59 11.92 200 105315 28482 63355025
Treatment failure 133.33 11.92 83 105432 198960 63184547
Dysarthria 130.88 11.92 246 105269 42465 63341042
Confusional state 130.40 11.92 753 104762 235627 63147880
Neutropenia 128.70 11.92 604 104911 174401 63209106
Cardio-respiratory arrest 126.09 11.92 296 105219 59663 63323844
Mental impairment 124.49 11.92 135 105380 14016 63369491
Anxiety 121.94 11.92 696 104819 216845 63166662
Arthritis 120.91 11.92 23 105492 115898 63267609
Obsessive-compulsive disorder 119.68 11.92 78 105437 3982 63379525
Pneumonia aspiration 117.30 11.92 208 105307 34332 63349175
Cough 115.49 11.92 193 105322 292550 63090957
Blister 115.44 11.92 36 105479 129778 63253729
Amenorrhoea 115.36 11.92 110 105405 9804 63373703
Psoriatic arthropathy 114.98 11.92 10 105505 91510 63291997
Mental disorder 114.88 11.92 176 105339 25743 63357764
Leukopenia 114.78 11.92 335 105180 76955 63306552
Disorientation 114.44 11.92 222 105293 39230 63344277
Blood triglycerides increased 113.13 11.92 121 105394 12367 63371140
Pericarditis 112.59 11.92 39 105476 131540 63251967
Product dose omission issue 110.65 11.92 136 105379 234177 63149330
Wound 108.05 11.92 69 105446 163194 63220313
Myocarditis 107.87 11.92 108 105407 10217 63373290
Impaired healing 107.68 11.92 20 105495 102522 63280985
Respiratory depression 107.18 11.92 123 105392 13592 63369915
Antipsychotic drug level above therapeutic 106.56 11.92 46 105469 997 63382510
Stomatitis 105.83 11.92 49 105466 138676 63244831
Psychiatric symptom 104.17 11.92 79 105436 5144 63378363
Psychomotor retardation 103.56 11.92 70 105445 3800 63379707
Osteoarthritis 101.40 11.92 18 105497 95325 63288182
Pulmonary embolism 99.52 11.92 421 105094 116263 63267244
Apathy 99.35 11.92 96 105419 8698 63374809
Bipolar disorder 97.75 11.92 91 105424 7869 63375638
Increased appetite 97.44 11.92 99 105416 9531 63373976
Infection 96.11 11.92 145 105370 229028 63154479
Diabetic coma 94.77 11.92 38 105477 679 63382828
Injection site erythema 94.57 11.92 13 105502 83161 63300346
Granulocytopenia 94.17 11.92 77 105438 5595 63377912
Hallucinations, mixed 94.02 11.92 72 105443 4757 63378750
Nausea 93.77 11.92 939 104576 853532 62529975
Generalised tonic-clonic seizure 93.75 11.92 171 105344 28845 63354662
Exposure during pregnancy 93.31 11.92 507 105008 155040 63228467
Folliculitis 93.11 11.92 6 105509 70311 63313196
Obesity 92.36 11.92 173 105342 29779 63353728
Dyslipidaemia 91.71 11.92 85 105430 7308 63376199
Disturbance in attention 90.83 11.92 198 105317 37991 63345516
Chest discomfort 90.02 11.92 35 105480 109934 63273573
Irritable bowel syndrome 88.86 11.92 15 105500 82397 63301110
Impulse-control disorder 87.85 11.92 37 105478 753 63382754
Obsessive-compulsive symptom 86.79 11.92 21 105494 54 63383453
Respiratory arrest 86.62 11.92 177 105338 32468 63351039
Seizure 84.09 11.92 439 105076 132195 63251312
Refusal of examination 82.98 11.92 25 105490 178 63383329
Gastrointestinal disorder 82.09 11.92 59 105456 131180 63252327
Lower respiratory tract infection 82.08 11.92 60 105455 132247 63251260
Mutism 81.37 11.92 44 105471 1586 63381921
Intentional product use issue 80.65 11.92 57 105458 127835 63255672
Mobility decreased 80.43 11.92 51 105464 121108 63262399
Cogwheel rigidity 78.84 11.92 46 105469 1924 63381583
Fibromyalgia 77.65 11.92 19 105496 80401 63303106
Thinking abnormal 77.41 11.92 92 105423 10551 63372956
Torsade de pointes 77.34 11.92 103 105412 13248 63370259
Substance abuse 77.18 11.92 64 105451 4743 63378764
Sinus tachycardia 77.11 11.92 142 105373 24126 63359381
Eosinophil count decreased 74.34 11.92 46 105469 2144 63381363
Sleep disorder due to general medical condition, insomnia type 73.72 11.92 3 105512 52214 63331293
Polydipsia 73.50 11.92 55 105460 3509 63379998
Irritability 72.73 11.92 162 105353 31532 63351975
Negativism 72.58 11.92 27 105488 390 63383117
Muscle injury 72.46 11.92 11 105504 65334 63318173
Product use issue 72.44 11.92 162 105353 220358 63163149
Myalgia 72.39 11.92 82 105433 146447 63237060
Musculoskeletal stiffness 70.64 11.92 124 105391 184494 63199013
Insurance issue 69.48 11.92 67 105448 6054 63377453
Cardiac arrest 69.12 11.92 321 105194 92224 63291283
Asthma 67.92 11.92 67 105448 127494 63256013
Knee arthroplasty 67.87 11.92 6 105509 54200 63329307
Hyponatraemia 67.25 11.92 365 105150 111535 63271972
Speech disorder 67.04 11.92 183 105332 40446 63343061
Loss of consciousness 66.79 11.92 379 105136 117742 63265765
Hyperglycaemia 66.53 11.92 186 105329 41681 63341826
Hypoaesthesia 64.51 11.92 113 105402 168280 63215227
Inflammation 64.39 11.92 28 105487 82245 63301262
Intentional product misuse 64.22 11.92 235 105280 60682 63322825
Euphoric mood 64.16 11.92 58 105457 4829 63378678
Poisoning 63.50 11.92 95 105420 13605 63369902
Blood bilirubin increased 63.00 11.92 169 105346 36971 63346536
Musculoskeletal pain 62.41 11.92 38 105477 92239 63291268
Injection site pruritus 62.35 11.92 3 105512 45113 63338394
Abdominal pain upper 61.97 11.92 159 105356 206285 63177222
Anaphylactic reaction 61.17 11.92 17 105498 66083 63317424
Unresponsive to stimuli 60.54 11.92 157 105358 33659 63349848
Hallucination, visual 60.16 11.92 112 105403 19186 63364321
Neutrophil count decreased 59.79 11.92 218 105297 56188 63327319
Electroencephalogram abnormal 59.18 11.92 49 105466 3623 63379884
Depression 58.37 11.92 540 104975 195952 63187555
Accidental death 58.33 11.92 38 105477 1938 63381569
Altered state of consciousness 57.94 11.92 129 105386 25101 63358406
Screaming 57.79 11.92 46 105469 3216 63380291
Food craving 57.75 11.92 35 105480 1571 63381936
Hip arthroplasty 57.73 11.92 6 105509 47640 63335867
Polyuria 57.50 11.92 71 105444 8471 63375036
Bradykinesia 57.41 11.92 56 105459 5132 63378375
Injection site bruising 57.24 11.92 3 105512 41907 63341600
Personality change due to a general medical condition 56.94 11.92 19 105496 195 63383312
Hypertonia 56.91 11.92 53 105462 4584 63378923
Obsessive thoughts 56.91 11.92 25 105490 566 63382941
Asthma-chronic obstructive pulmonary disease overlap syndrome 56.87 11.92 38 105477 2023 63381484
Influenza 56.85 11.92 58 105457 108664 63274843
Trimethylaminuria 56.75 11.92 18 105497 155 63383352
Injection site reaction 56.16 11.92 14 105501 58510 63324997
Maternal exposure during pregnancy 55.49 11.92 184 105331 219878 63163629
Cognitive disorder 55.23 11.92 211 105304 55604 63327903
Bipolar I disorder 54.79 11.92 36 105479 1863 63381644
Plasma cell mastitis 54.42 11.92 13 105502 31 63383476
Acute psychosis 54.39 11.92 40 105475 2485 63381022
Muscle spasms 54.35 11.92 111 105404 156039 63227468
Herpes zoster 54.32 11.92 35 105480 82427 63301080
Mydriasis 54.12 11.92 82 105433 11874 63371633
Hepatocellular injury 54.12 11.92 132 105383 27249 63356258
Total lung capacity increased 52.95 11.92 38 105477 2272 63381235
Drooling 52.94 11.92 47 105468 3821 63379686
Diet refusal 52.59 11.92 24 105491 596 63382911
Somatic symptom disorder of pregnancy 51.98 11.92 15 105500 90 63383417
Contusion 51.93 11.92 107 105408 149937 63233570
Dyspepsia 51.77 11.92 56 105459 102140 63281367
Urinary retention 51.51 11.92 138 105377 30163 63353344
Refusal of treatment by patient 51.09 11.92 54 105461 5443 63378064
Paraesthesia 50.96 11.92 116 105399 156850 63226657
Stupor 50.81 11.92 48 105467 4227 63379280
Psoriasis 49.44 11.92 43 105472 86914 63296593
Prescribed overdose 48.73 11.92 146 105369 34007 63349500
Coma scale abnormal 48.57 11.92 51 105464 5102 63378405
Malaise 48.38 11.92 450 105065 415504 62968003
C-reactive protein abnormal 48.36 11.92 9 105506 46087 63337420
Chest pain 48.20 11.92 190 105325 215769 63167738
Logorrhoea 47.94 11.92 37 105478 2473 63381034
White blood cell count decreased 47.90 11.92 395 105120 138709 63244798
Megacolon 47.37 11.92 33 105482 1882 63381625
Hyperphagia 47.18 11.92 32 105483 1747 63381760
Hyperammonaemic encephalopathy 46.75 11.92 36 105479 2398 63381109
Symptom recurrence 46.67 11.92 32 105483 1778 63381729
Rebound psychosis 46.48 11.92 16 105499 182 63383325
Neck pain 46.24 11.92 29 105486 69289 63314218
Affective disorder 46.14 11.92 54 105461 6092 63377415
White blood cell count increased 45.95 11.92 181 105334 48380 63335127
Cholelithiasis 45.91 11.92 169 105346 43756 63339751
Osteoporosis 45.68 11.92 19 105496 57319 63326188
Impulsive behaviour 45.65 11.92 30 105485 1553 63381954
Erythema 45.64 11.92 145 105370 175606 63207901
Neuropathy peripheral 45.62 11.92 74 105441 113593 63269914
Flushing 45.33 11.92 35 105480 75052 63308455
Sinus rhythm 45.24 11.92 24 105491 832 63382675
Sciatica 45.22 11.92 3 105512 34321 63349186
Sudden death 44.96 11.92 70 105445 10379 63373128
Self esteem decreased 44.66 11.92 22 105493 651 63382856
Behaviour disorder 44.04 11.92 39 105476 3160 63380347
Gamma-glutamyltransferase increased 43.48 11.92 140 105375 33891 63349616
Ill-defined disorder 43.44 11.92 43 105472 81712 63301795
Device expulsion 43.35 11.92 4 105511 34918 63348589
Apallic syndrome 43.22 11.92 22 105493 699 63382808
Brain stem thrombosis 43.21 11.92 8 105507 0 63383507
Homicide 42.71 11.92 18 105497 367 63383140
Withdrawal syndrome 42.32 11.92 99 105416 19898 63363609
Myocardial reperfusion injury 42.16 11.92 13 105502 101 63383406
Bursitis 41.61 11.92 6 105509 37035 63346472
Psychotic disorder due to a general medical condition 41.29 11.92 16 105499 260 63383247
COVID-19 40.55 11.92 79 105436 113024 63270483
Brain injury 40.28 11.92 54 105461 6989 63376518
Joint range of motion decreased 39.50 11.92 4 105511 32424 63351083
Oropharyngeal pain 39.35 11.92 60 105455 94427 63289080
Dyspnoea exertional 39.16 11.92 26 105489 60276 63323231
Injection site swelling 39.15 11.92 15 105500 47557 63335950
Bone pain 39.08 11.92 21 105494 54620 63328887
Psychomotor skills impaired 39.00 11.92 32 105483 2336 63381171
Delusion of reference 38.61 11.92 12 105503 96 63383411
Hypernatraemia 38.51 11.92 55 105460 7554 63375953
Agranulocytosis 38.30 11.92 110 105405 25024 63358483
Nasal congestion 37.90 11.92 32 105483 65628 63317879
Abdominal pain 37.84 11.92 309 105206 293147 63090360
Self-injurious ideation 37.77 11.92 33 105482 2626 63380881
Inappropriate antidiuretic hormone secretion 37.71 11.92 81 105434 15381 63368126
Depressive symptom 37.60 11.92 40 105475 4062 63379445
Night sweats 37.58 11.92 17 105498 48797 63334710
Electrocardiogram T wave inversion 37.45 11.92 37 105478 3444 63380063
Hepatotoxicity 37.44 11.92 141 105374 36900 63346607
Bezoar 37.05 11.92 26 105489 1500 63382007
Negative symptoms in schizophrenia 36.98 11.92 12 105503 112 63383395
Alanine aminotransferase increased 36.97 11.92 297 105218 103473 63280034
Wheezing 36.73 11.92 64 105451 95531 63287976
Gynaecomastia 36.56 11.92 14 105501 220 63383287
Diabetic ketoacidosis 36.49 11.92 95 105420 20410 63363097
Mental status changes 36.18 11.92 146 105369 39453 63344054
Throat irritation 36.13 11.92 9 105506 37638 63345869
Phagophobia 36.02 11.92 10 105505 51 63383456
Menstruation irregular 35.99 11.92 51 105464 6953 63376554
Weight decreased 35.89 11.92 291 105224 276507 63107000
Depressed mood 35.78 11.92 147 105368 40044 63343463
Breast enlargement 35.43 11.92 26 105489 1610 63381897
Abulia 35.37 11.92 17 105498 476 63383031
Cor pulmonale acute 35.37 11.92 16 105499 389 63383118
Encephalitis autoimmune 35.34 11.92 25 105490 1461 63382046
Ataxia 35.23 11.92 78 105437 15117 63368390
Hypokinesia 35.13 11.92 74 105441 13862 63369645
Illusion 35.12 11.92 22 105493 1048 63382459
Breast discomfort 34.98 11.92 17 105498 488 63383019
Head banging 34.96 11.92 16 105499 400 63383107
Pressure of speech 34.59 11.92 19 105496 707 63382800
Osteonecrosis of jaw 34.49 11.92 8 105507 35115 63348392
Myocardial hypoxia 34.45 11.92 8 105507 16 63383491
Ketosis-prone diabetes mellitus 34.45 11.92 8 105507 16 63383491
Circulatory collapse 34.39 11.92 97 105418 21841 63361666
Liver injury 34.31 11.92 30 105485 60490 63323017
Multiple sclerosis relapse 34.14 11.92 19 105496 48459 63335048
Neutrophil count increased 34.08 11.92 81 105434 16446 63367061
Feeling hot 33.67 11.92 21 105494 50333 63333174
Flat affect 33.58 11.92 24 105491 1426 63382081
Hot flush 33.30 11.92 22 105493 51137 63332370
Grandiosity 33.19 11.92 14 105501 286 63383221
Monocyte count decreased 33.19 11.92 28 105487 2125 63381382
Bronchitis 33.19 11.92 102 105413 124833 63258674
Embolism venous 32.96 11.92 33 105482 3121 63380386
Hypoxic-ischaemic encephalopathy 32.74 11.92 38 105477 4249 63379258
Insomnia 32.74 11.92 521 104994 214731 63168776
Basal cell carcinoma 32.71 11.92 4 105511 27987 63355520
Lethargy 32.49 11.92 181 105334 55826 63327681
Electrocardiogram QT interval abnormal 32.47 11.92 12 105503 170 63383337
Oral herpes 32.33 11.92 3 105512 26071 63357436
Myoclonic epilepsy 31.93 11.92 22 105493 1232 63382275
Myoclonus 31.89 11.92 77 105438 15791 63367716
Skin exfoliation 31.66 11.92 16 105499 43086 63340421
Epilepsy 31.60 11.92 108 105407 26957 63356550
Skin ulcer 31.59 11.92 16 105499 43029 63340478
Blunted affect 31.54 11.92 13 105502 250 63383257
Waxy flexibility 31.50 11.92 11 105504 131 63383376
Migraine 31.44 11.92 79 105436 103267 63280240
Influenza like illness 31.27 11.92 39 105476 66785 63316722
Chills 31.24 11.92 91 105424 113287 63270220
Distractibility 30.92 11.92 15 105500 429 63383078
Haemoglobin urine 30.91 11.92 11 105504 139 63383368
Respiratory dyskinesia 30.39 11.92 8 105507 32 63383475
Diabetic hyperosmolar coma 30.37 11.92 14 105501 356 63383151
Joint stiffness 30.08 11.92 16 105499 41853 63341654
Thought blocking 29.95 11.92 11 105504 153 63383354
Muscle twitching 29.89 11.92 86 105429 19582 63363925
Blood pressure increased 29.88 11.92 153 105362 161909 63221598
Eosinophil count increased 29.87 11.92 60 105455 10868 63372639
Feeling guilty 29.86 11.92 16 105499 566 63382941
Leukocytosis 29.85 11.92 103 105412 25832 63357675
Upper respiratory tract infection 29.67 11.92 57 105458 81990 63301517
Labelled drug-drug interaction issue 29.66 11.92 20 105495 1081 63382426
Urinary tract infection 29.59 11.92 289 105226 264395 63119112
Eosinophilia 29.42 11.92 94 105421 22662 63360845
Cataract 29.18 11.92 31 105484 57022 63326485
Abnormal clotting factor 29.11 11.92 10 105505 113 63383394
Interstitial lung disease 29.10 11.92 36 105479 61872 63321635
Injury 29.09 11.92 48 105467 73199 63310308
Pulmonary fibrosis 28.91 11.92 15 105500 39794 63343713
Asthenia 28.88 11.92 456 105059 383148 63000359
Haematochezia 28.63 11.92 28 105487 53516 63329991
Coma scale 28.62 11.92 8 105507 42 63383465
Disinhibition 28.59 11.92 18 105497 865 63382642
Oromandibular dystonia 28.49 11.92 15 105500 512 63382995
Ear infection 28.35 11.92 14 105501 38199 63345308
Suicidal behaviour 28.30 11.92 28 105487 2611 63380896
Pharyngeal dystonia 28.26 11.92 6 105509 6 63383501
Arrhythmia 28.24 11.92 132 105383 38008 63345499
Major depression 28.14 11.92 49 105466 7969 63375538
Hallucination, olfactory 28.10 11.92 12 105503 253 63383254
Withdrawal catatonia 28.03 11.92 9 105506 81 63383426
Ventricular arrhythmia 27.69 11.92 33 105482 3795 63379712
Poisoning deliberate 27.62 11.92 59 105456 11159 63372348
Loss of personal independence in daily activities 27.60 11.92 77 105438 97213 63286294
Neoplasm progression 27.55 11.92 13 105502 36415 63347092
Asphyxia 27.42 11.92 42 105473 6139 63377368
Diverticulitis 27.14 11.92 16 105499 39541 63343966
Device dislocation 27.00 11.92 5 105510 25700 63357807
Rash pruritic 26.85 11.92 36 105479 59763 63323744
Limb discomfort 26.83 11.92 8 105507 29708 63353799
Autonomic nervous system imbalance 26.76 11.92 28 105487 2790 63380717
Disease progression 26.73 11.92 109 105406 122649 63260858
Grip strength decreased 26.51 11.92 3 105512 22284 63361223
Muscular weakness 26.42 11.92 109 105406 122244 63261263
Anaphylactic shock 26.15 11.92 4 105511 23629 63359878
Rhinorrhoea 26.02 11.92 43 105472 65534 63317973
Hypophagia 26.01 11.92 112 105403 31147 63352360
Discoloured vomit 25.92 11.92 17 105498 877 63382630
Polydipsia psychogenic 25.85 11.92 8 105507 63 63383444
Type 2 diabetes mellitus 25.64 11.92 188 105327 63680 63319827
Water intoxication 25.51 11.92 13 105502 414 63383093
Suspected suicide 25.51 11.92 42 105473 6526 63376981
Drug resistance 25.46 11.92 90 105425 22843 63360664
Akinesia 25.14 11.92 21 105494 1572 63381935
Bundle branch block right 25.10 11.92 36 105479 4962 63378545
Stereotypy 25.09 11.92 13 105502 429 63383078
Somnambulism 25.07 11.92 38 105477 5505 63378002
Bone disorder 25.04 11.92 3 105512 21323 63362184
Long QT syndrome 24.93 11.92 29 105486 3250 63380257
Pleural effusion 24.82 11.92 76 105439 93134 63290373
Antipsychotic drug level decreased 24.81 11.92 12 105503 341 63383166
International normalised ratio abnormal 24.76 11.92 29 105486 3275 63380232
Drug withdrawal syndrome 24.63 11.92 100 105415 27094 63356413
Hyperreflexia 24.49 11.92 39 105476 5895 63377612
Flight of ideas 24.23 11.92 13 105502 461 63383046
Device issue 24.19 11.92 5 105510 23776 63359731
Impaired self-care 24.17 11.92 22 105493 1848 63381659
Selective eating disorder 24.12 11.92 23 105492 2049 63381458
Food refusal 24.12 11.92 12 105503 363 63383144
Suspiciousness 24.00 11.92 12 105503 367 63383140
Stress 23.99 11.92 47 105468 67120 63316387
Oropharyngeal spasm 23.96 11.92 11 105504 277 63383230
Consciousness fluctuating 23.96 11.92 16 105499 851 63382656
Thermal burn 23.94 11.92 39 105476 6007 63377500
Accidental overdose 23.78 11.92 89 105426 23220 63360287
Tachypnoea 23.78 11.92 73 105442 17229 63366278
Acquired haemophilia 23.72 11.92 17 105498 1014 63382493
Illness 23.62 11.92 28 105487 49031 63334476
Hypoventilation 23.52 11.92 34 105481 4720 63378787
Cardiac failure congestive 23.47 11.92 77 105438 92356 63291151
Aspartate aminotransferase increased 23.29 11.92 241 105274 90036 63293471
Central nervous system lupus 23.25 11.92 13 105502 501 63383006
High density lipoprotein decreased 23.22 11.92 23 105492 2147 63381360
Troponin abnormal 23.21 11.92 7 105508 50 63383457
Gastric disorder 23.09 11.92 17 105498 37352 63346155
Electrocardiogram J wave 23.08 11.92 5 105510 6 63383501
Hypotonia 23.05 11.92 49 105466 9236 63374271
Sarcoidosis 23.03 11.92 42 105473 7080 63376427
Echolalia 23.03 11.92 10 105505 220 63383287
Injection site haemorrhage 22.97 11.92 6 105509 24308 63359199
Pain in jaw 22.96 11.92 23 105492 43473 63340034
Differential white blood cell count abnormal 22.92 11.92 15 105500 771 63382736
Febrile neutropenia 22.88 11.92 299 105216 118150 63265357
Staring 22.69 11.92 20 105495 1610 63381897
Hyporesponsive to stimuli 22.68 11.92 17 105498 1087 63382420
Ketoacidosis 22.68 11.92 32 105483 4346 63379161
Meige's syndrome 22.64 11.92 5 105510 7 63383500
Nasal polyps 22.63 11.92 38 105477 6001 63377506
Abnormal weight gain 22.62 11.92 21 105494 1809 63381698
Thrombosis 22.54 11.92 46 105469 64709 63318798
Fungal infection 22.49 11.92 17 105498 36857 63346650
Pulmonary mass 22.48 11.92 5 105510 22591 63360916
Antiphospholipid antibodies 22.43 11.92 9 105506 161 63383346
Ideas of reference 22.41 11.92 8 105507 102 63383405
Personality disorder 22.36 11.92 37 105478 5774 63377733
Electrocardiogram J wave abnormal 22.24 11.92 5 105510 8 63383499
Burning sensation 22.22 11.92 35 105480 54372 63329135
Cytomegalovirus infection 22.17 11.92 4 105511 20948 63362559
Seasonal allergy 22.17 11.92 4 105511 20946 63362561
Delusional disorder, erotomanic type 22.05 11.92 6 105509 28 63383479
Lung disorder 21.87 11.92 44 105471 62217 63321290
Respiratory tract infection 21.82 11.92 22 105493 41461 63342046
Pancreatitis 21.80 11.92 148 105367 48907 63334600
Ileus paralytic 21.72 11.92 32 105483 4519 63378988
Anaemia 21.66 11.92 350 105165 293080 63090427
Ear pain 21.59 11.92 17 105498 36101 63347406
Insulin C-peptide increased 21.42 11.92 7 105508 67 63383440
Retinal coloboma 21.39 11.92 6 105509 32 63383475
Nephrolithiasis 21.26 11.92 23 105492 41961 63341546
Macular degeneration 21.23 11.92 7 105508 24369 63359138
Immunodeficiency 21.15 11.92 4 105511 20250 63363257
Fluid retention 21.12 11.92 42 105473 59644 63323863
Localised infection 21.04 11.92 12 105503 30198 63353309
Malignant catatonia 21.02 11.92 9 105506 191 63383316
Procedural pain 21.00 11.92 5 105510 21564 63361943
Atrial fibrillation 20.99 11.92 111 105404 116525 63266982
Ventricular dyskinesia 20.99 11.92 8 105507 124 63383383
Wrong drug 20.89 11.92 9 105506 194 63383313
Oral candidiasis 20.84 11.92 6 105509 22792 63360715
Wound infection 20.78 11.92 5 105510 21405 63362102
Troponin T increased 20.77 11.92 17 105498 1237 63382270
Intellectual disability 20.72 11.92 16 105499 1070 63382437
Parkinsonian gait 20.46 11.92 12 105503 507 63383000
Compulsions 20.40 11.92 9 105506 206 63383301
Overweight 20.30 11.92 28 105487 3723 63379784
Adverse event 20.27 11.92 52 105463 67507 63316000
Fear 20.27 11.92 65 105450 15701 63367806
Productive cough 20.26 11.92 47 105468 63161 63320346
Ulcer 20.24 11.92 9 105506 26098 63357409
Iris coloboma 20.13 11.92 6 105509 41 63383466
Surgery 20.12 11.92 18 105497 35894 63347613
Psychogenic visual disorder 20.10 11.92 5 105510 15 63383492
Unevaluable event 20.10 11.92 34 105481 51352 63332155
Gastrointestinal sounds abnormal 20.09 11.92 29 105486 4022 63379485
Type 1 diabetes mellitus 20.07 11.92 28 105487 3762 63379745
Cystitis 20.06 11.92 38 105477 54953 63328554
Electrocardiogram abnormal 20.03 11.92 46 105469 9133 63374374
Skin discolouration 19.97 11.92 20 105495 37808 63345699
Hyperthermia malignant 19.76 11.92 14 105501 820 63382687
Blood pressure fluctuation 19.68 11.92 29 105486 46288 63337219
Dysphoria 19.62 11.92 32 105483 4934 63378573
Mean cell haemoglobin concentration decreased 19.60 11.92 27 105488 3585 63379922
Kidney infection 19.59 11.92 7 105508 23169 63360338
Red blood cells urine 19.51 11.92 12 105503 553 63382954
Lower limb fracture 19.33 11.92 8 105507 24213 63359294
Hypersomnia 19.31 11.92 70 105445 17985 63365522
Brain death 19.28 11.92 26 105489 3384 63380123
Feelings of worthlessness 19.19 11.92 10 105505 334 63383173
Condition aggravated 19.12 11.92 834 104681 401383 62982124
Dysgeusia 19.12 11.92 30 105485 46680 63336827
Body mass index increased 19.08 11.92 16 105499 1204 63382303
Maternal exposure during breast feeding 19.07 11.92 29 105486 4212 63379295
Postural tremor 19.00 11.92 10 105505 341 63383166
Cellulitis 18.97 11.92 71 105444 81887 63301620
Hepatic enzyme increased 18.96 11.92 230 105285 202098 63181409
Femur fracture 18.88 11.92 25 105490 41731 63341776
Joint injury 18.87 11.92 13 105502 29559 63353948
Patient dissatisfaction with treatment 18.83 11.92 7 105508 101 63383406
Hypercapnia 18.81 11.92 33 105482 5398 63378109
Delusion of grandeur 18.79 11.92 9 105506 250 63383257
Incontinence 18.79 11.92 52 105463 11580 63371927
Product packaging confusion 18.72 11.92 8 105507 169 63383338
Hepatitis toxic 18.69 11.92 25 105490 3228 63380279
Joint effusion 18.62 11.92 3 105512 17057 63366450
Ventricular tachycardia 18.52 11.92 74 105441 19905 63363602
Infusion site pain 18.33 11.92 3 105512 16866 63366641
Tubo-ovarian abscess 18.33 11.92 10 105505 367 63383140
Palpitations 18.30 11.92 111 105404 112659 63270848
Tendonitis 18.23 11.92 5 105510 19610 63363897
Haemorrhoids 18.20 11.92 7 105508 22143 63361364
Caesarean section 18.19 11.92 66 105449 16966 63366541
Sneezing 18.18 11.92 4 105511 18214 63365293
Dissociative disorder 18.08 11.92 10 105505 377 63383130
Taciturnity 17.95 11.92 4 105511 6 63383501
Genitourinary symptom 17.95 11.92 6 105509 62 63383445
Torticollis 17.85 11.92 19 105496 1930 63381577
Delusional disorder, unspecified type 17.84 11.92 10 105505 387 63383120
Cardiac murmur 17.81 11.92 59 105456 14493 63369014
Product quality issue 17.77 11.92 20 105495 35845 63347662
Paraesthesia oral 17.72 11.92 5 105510 19251 63364256
Hypertransaminasaemia 17.72 11.92 36 105479 6573 63376934
Reduced facial expression 17.72 11.92 19 105496 1947 63381560
Foetal exposure during pregnancy 17.68 11.92 102 105413 31860 63351647
Nuchal rigidity 17.66 11.92 12 105503 657 63382850
Neonatal respiratory depression 17.53 11.92 6 105509 67 63383440
Mucosal inflammation 17.49 11.92 32 105483 46896 63336611
Drug monitoring procedure incorrectly performed 17.48 11.92 8 105507 200 63383307
Hospitalisation 17.37 11.92 217 105298 84864 63298643
Mean cell haemoglobin decreased 17.33 11.92 31 105484 5148 63378359
Cyclothymic disorder 17.29 11.92 6 105509 70 63383437
Mucosal dryness 17.18 11.92 22 105493 2722 63380785
Affect lability 17.18 11.92 49 105466 11102 63372405
Slow response to stimuli 17.11 11.92 14 105501 1018 63382489
Self-medication 17.06 11.92 22 105493 2741 63380766
Central obesity 17.04 11.92 15 105500 1206 63382301
Chorea 16.99 11.92 17 105498 1607 63381900
Sluggishness 16.95 11.92 31 105484 5238 63378269
Constricted affect 16.91 11.92 4 105511 9 63383498
Insulin resistance 16.89 11.92 13 105502 865 63382642
Hypotonia neonatal 16.77 11.92 15 105500 1231 63382276
Osteonecrosis 16.72 11.92 10 105505 24520 63358987
Live birth 16.71 11.92 11 105504 25619 63357888
Metastases to bone 16.68 11.92 7 105508 21012 63362495
Brief psychotic disorder, with postpartum onset 16.67 11.92 5 105510 35 63383472
Glutamate dehydrogenase increased 16.67 11.92 5 105510 35 63383472
Eosinophil count abnormal 16.61 11.92 11 105504 577 63382930
Anger 16.60 11.92 52 105463 12404 63371103
Therapy partial responder 16.58 11.92 47 105468 10611 63372896
Grunting 16.55 11.92 8 105507 227 63383280
Morose 16.55 11.92 5 105510 36 63383471
Cerebral atrophy 16.54 11.92 30 105485 5036 63378471
Disease recurrence 16.53 11.92 91 105424 27939 63355568
Limb injury 16.52 11.92 11 105504 25466 63358041
Areflexia 16.46 11.92 23 105492 3095 63380412
Toxic leukoencephalopathy 16.41 11.92 12 105503 739 63382768
Decreased gait velocity 16.34 11.92 4 105511 11 63383496
Atonic urinary bladder 16.30 11.92 6 105509 84 63383423
Muscle contractions involuntary 16.29 11.92 20 105495 2372 63381135
Skin disorder 16.28 11.92 15 105500 29492 63354015
Amaurosis 16.26 11.92 11 105504 598 63382909
Neurosyphilis 16.20 11.92 3 105512 0 63383507
Inborn error of metabolism 16.20 11.92 3 105512 0 63383507
Intermittent explosive disorder 16.20 11.92 3 105512 0 63383507
Excessive masturbation 16.20 11.92 3 105512 0 63383507
Transient aphasia 16.20 11.92 5 105510 39 63383468
Extensor plantar response 16.12 11.92 15 105500 1296 63382211
Substance-induced psychotic disorder 16.10 11.92 18 105497 1933 63381574
Opisthotonus 16.09 11.92 9 105506 347 63383160
Microphthalmos 16.08 11.92 7 105508 155 63383352
Large for dates baby 16.03 11.92 10 105505 473 63383034
Wrong patient received product 15.92 11.92 19 105496 2188 63381319
Homicidal ideation 15.91 11.92 17 105498 1735 63381772
Hepatic function abnormal 15.87 11.92 111 105404 37031 63346476
CSF glucose increased 15.77 11.92 5 105510 43 63383464
Single umbilical artery 15.72 11.92 8 105507 254 63383253
Eating disorder 15.71 11.92 68 105447 18948 63364559
Bruxism 15.70 11.92 24 105491 3501 63380006
Palmoplantar keratoderma 15.68 11.92 18 105497 1989 63381518
Rhinitis allergic 15.67 11.92 49 105466 11678 63371829
Dysphonia 15.59 11.92 35 105480 47579 63335928
Communication disorder 15.59 11.92 20 105495 2480 63381027
Bicytopenia 15.55 11.92 20 105495 2485 63381022
Toxic encephalopathy 15.51 11.92 34 105481 6545 63376962
Bradycardia 15.48 11.92 188 105327 73039 63310468
Product substitution issue 15.43 11.92 60 105455 15936 63367571
Resting tremor 15.43 11.92 12 105503 811 63382696
Drug level above therapeutic 15.12 11.92 28 105487 4777 63378730
Gaze palsy 15.10 11.92 15 105500 1405 63382102
Hepatic cytolysis 15.03 11.92 58 105457 15349 63368158
Lipids abnormal 14.88 11.92 8 105507 285 63383222
Analgesic drug level increased 14.83 11.92 19 105496 2353 63381154
Blood alkaline phosphatase increased 14.76 11.92 122 105393 42845 63340662
Cardiospasm 14.73 11.92 17 105498 1890 63381617
Affective ambivalence 14.64 11.92 4 105511 19 63383488
Blood urea decreased 14.64 11.92 19 105496 2383 63381124
Full blood count decreased 14.63 11.92 13 105502 26011 63357496
Helplessness 14.60 11.92 8 105507 296 63383211
Neuralgia 14.51 11.92 13 105502 25913 63357594
Heart rate decreased 14.50 11.92 34 105481 45526 63337981
Sleep terror 14.49 11.92 20 105495 2660 63380847
Ventricular fibrillation 14.42 11.92 48 105467 11819 63371688
Dysbiosis 14.41 11.92 12 105503 894 63382613
Foot deformity 14.39 11.92 15 105500 27838 63355669
Myelosuppression 14.36 11.92 11 105504 23692 63359815
Compulsive sexual behaviour 14.36 11.92 5 105510 59 63383448
Chronic kidney disease 14.36 11.92 34 105481 45364 63338143
Inappropriate affect 14.32 11.92 12 105503 902 63382605
Tenderness 14.30 11.92 10 105505 22568 63360939
Brief psychotic disorder with marked stressors 14.28 11.92 5 105510 60 63383447
Peripheral venous disease 14.28 11.92 4 105511 15473 63368034
Deafness 14.22 11.92 6 105509 17951 63365556
Progressive supranuclear palsy 14.21 11.92 5 105510 61 63383446
Slow speech 14.17 11.92 15 105500 1514 63381993
Medication error 14.16 11.92 141 105374 52143 63331364
Asocial behaviour 14.16 11.92 4 105511 22 63383485
Pelvic sepsis 14.13 11.92 3 105512 3 63383504
Dyskinesia neonatal 14.13 11.92 3 105512 3 63383504
Onychogryphosis 14.13 11.92 3 105512 3 63383504
Facial wasting 14.13 11.92 3 105512 3 63383504
Pituitary tumour benign 14.10 11.92 17 105498 1978 63381529
Glucocorticoids increased 14.07 11.92 6 105509 126 63383381
Gastrointestinal lymphoma 14.06 11.92 5 105510 63 63383444
Poverty of speech 14.04 11.92 8 105507 320 63383187
Lupus-like syndrome 14.03 11.92 4 105511 15291 63368216
Butterfly rash 14.02 11.92 16 105499 1757 63381750
Accelerated hypertension 13.98 11.92 9 105506 450 63383057
Rash macular 13.96 11.92 11 105504 23353 63360154
Dependent personality disorder 13.92 11.92 5 105510 65 63383442
Oral pain 13.89 11.92 16 105499 28378 63355129
Echopraxia 13.86 11.92 4 105511 24 63383483
Syndactyly 13.83 11.92 9 105506 458 63383049
Blood pressure systolic increased 13.82 11.92 37 105478 47360 63336147
Joint dislocation 13.78 11.92 7 105508 18793 63364714
Malignant neoplasm progression 13.76 11.92 80 105435 82041 63301466
Incoherent 13.75 11.92 26 105489 4504 63379003
Pupillary reflex impaired 13.75 11.92 17 105498 2030 63381477
Emotional distress 13.75 11.92 97 105418 32452 63351055
White blood cells urine positive 13.72 11.92 28 105487 5130 63378377
Gastrointestinal haemorrhage 13.65 11.92 79 105436 81097 63302410
Pseudomembranous colitis 13.60 11.92 21 105494 3091 63380416
Newborn persistent pulmonary hypertension 13.59 11.92 7 105508 228 63383279
Drug tolerance decreased 13.58 11.92 6 105509 17467 63366040
Muscle tone disorder 13.57 11.92 6 105509 138 63383369
Haematocrit increased 13.56 11.92 18 105497 2308 63381199
Palmar-plantar erythrodysaesthesia syndrome 13.54 11.92 11 105504 23004 63360503
Alcohol use 13.54 11.92 17 105498 2062 63381445
Metamyelocyte count increased 13.54 11.92 7 105508 230 63383277
Brain oedema 13.49 11.92 53 105462 14142 63369365
Suspected suicide attempt 13.49 11.92 6 105509 140 63383367
Electrocardiogram ST segment abnormal 13.46 11.92 12 105503 981 63382526
Onychophagia 13.46 11.92 5 105510 72 63383435
Swelling face 13.42 11.92 57 105458 63418 63320089
Myoglobin blood increased 13.41 11.92 14 105501 1391 63382116
Respiratory disorder 13.40 11.92 28 105487 39054 63344453
Foot fracture 13.38 11.92 12 105503 23902 63359605
Ovarian germ cell cancer stage II 13.33 11.92 5 105510 74 63383433
Hypotension 13.32 11.92 567 104948 272037 63111470
Rash erythematous 13.31 11.92 32 105483 42478 63341029
Soliloquy 13.27 11.92 7 105508 240 63383267
Anticholinergic syndrome 13.22 11.92 18 105497 2364 63381143
Hypomagnesaemia 13.20 11.92 17 105498 28720 63354787
Drug abuser 13.16 11.92 20 105495 2903 63380604
Glassy eyes 13.15 11.92 5 105510 77 63383430
Therapy interrupted 13.13 11.92 21 105494 32434 63351073
Inappropriate schedule of product administration 13.13 11.92 110 105405 103855 63279652
Somatic symptom disorder 13.13 11.92 19 105496 2641 63380866
Alcohol abuse 13.12 11.92 17 105498 2129 63381378
Bone density decreased 13.07 11.92 4 105511 14608 63368899
Metastases to liver 13.06 11.92 12 105503 23627 63359880
Moaning 13.04 11.92 11 105504 835 63382672
Sinus disorder 12.94 11.92 13 105502 24540 63358967
Speech disorder developmental 12.93 11.92 10 105505 670 63382837
Hypersexuality 12.92 11.92 9 105506 513 63382994
Hyperinsulinism 12.92 11.92 3 105512 6 63383501
Alveolar capillary dysplasia 12.92 11.92 3 105512 6 63383501
Laryngitis 12.92 11.92 6 105509 16961 63366546
Paralogism 12.87 11.92 4 105511 32 63383475
Rash papular 12.84 11.92 5 105510 15697 63367810
Premature delivery 12.82 11.92 19 105496 30262 63353245
Product use in unapproved indication 12.82 11.92 389 105126 178691 63204816
Blood glucose 12.76 11.92 4 105511 33 63383474
Urinary incontinence 12.71 11.92 94 105421 31920 63351587
Viral infection 12.70 11.92 25 105490 35638 63347869
Lactic acidosis 12.65 11.92 28 105487 38259 63345248
Myelodysplastic syndrome 12.64 11.92 6 105509 16748 63366759
Haematocrit decreased 12.62 11.92 110 105405 39230 63344277
Pseudobulbar palsy 12.60 11.92 3 105512 7 63383500
Anterograde amnesia 12.54 11.92 9 105506 538 63382969
Hyperlipidaemia 12.53 11.92 65 105450 19506 63364001
Lung neoplasm malignant 12.43 11.92 65 105450 19568 63363939
Hyponatraemic syndrome 12.43 11.92 9 105506 546 63382961
Neurological examination normal 12.36 11.92 4 105511 37 63383470
Frequent bowel movements 12.35 11.92 12 105503 23010 63360497
Hypersomnia-bulimia syndrome 12.32 11.92 3 105512 8 63383499
Epileptic psychosis 12.26 11.92 4 105511 38 63383469
Osteopenia 12.22 11.92 9 105506 19776 63363731
Coagulation factor VII level decreased 12.19 11.92 5 105510 95 63383412
Negative thoughts 12.16 11.92 11 105504 916 63382591
Enuresis 12.15 11.92 18 105497 2555 63380952
Hepatitis C 12.14 11.92 27 105488 5247 63378260
Death 12.08 11.92 504 105011 373877 63009630
Thought insertion 12.06 11.92 3 105512 9 63383498
Alcoholism 12.06 11.92 15 105500 1803 63381704
Uveitis 12.05 11.92 3 105512 12550 63370957
Musculoskeletal disorder 11.98 11.92 10 105505 20634 63362873
Drug withdrawal syndrome neonatal 11.97 11.92 16 105499 2065 63381442
Crying 11.95 11.92 73 105442 23270 63360237
Pneumonia 11.93 11.92 629 104886 456138 62927369

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1945.72 12.12 998 107124 16936 34831873
Sedation 1235.89 12.12 784 107338 20222 34828587
Post-injection delirium sedation syndrome 1160.10 12.12 276 107846 218 34848591
Psychotic disorder 895.17 12.12 682 107440 23770 34825039
Akathisia 744.58 12.12 404 107718 7705 34841104
Extrapyramidal disorder 701.11 12.12 458 107664 12422 34836387
Agitation 698.86 12.12 874 107248 56525 34792284
Suicide attempt 693.99 12.12 724 107398 38392 34810417
Weight increased 664.54 12.12 1099 107023 91934 34756875
Overdose 629.36 12.12 1060 107062 89999 34758810
Schizophrenia 602.44 12.12 360 107762 8306 34840503
Aggression 575.66 12.12 655 107467 38309 34810500
Hallucination, auditory 550.99 12.12 383 107739 11534 34837275
Delusion 512.60 12.12 375 107747 12260 34836549
Intentional self-injury 499.13 12.12 382 107740 13389 34835420
Catatonia 496.74 12.12 263 107859 4762 34844047
Sopor 444.99 12.12 339 107783 11797 34837012
Parkinsonism 412.80 12.12 277 107845 7861 34840948
Blood creatine phosphokinase increased 387.85 12.12 579 107543 44278 34804531
Toxicity to various agents 382.60 12.12 1423 106699 198939 34649870
Dystonia 378.05 12.12 294 107828 10551 34838258
Somnolence 369.51 12.12 958 107164 110158 34738651
Intentional overdose 367.99 12.12 557 107565 43117 34805692
Muscle rigidity 362.01 12.12 283 107839 10235 34838574
Mania 360.45 12.12 271 107851 9240 34839569
Myocarditis 353.96 12.12 312 107810 13370 34835439
Prescribed overdose 352.52 12.12 280 107842 10367 34838442
Diarrhoea 327.13 12.12 438 107684 389474 34459335
Tachycardia 325.07 12.12 772 107350 84000 34764809
Electrocardiogram QT prolonged 306.99 12.12 495 107627 40457 34808352
Salivary hypersecretion 304.91 12.12 236 107886 8408 34840401
Arthralgia 301.93 12.12 77 108045 169964 34678845
Delirium 291.34 12.12 503 107619 43488 34805321
Hyperprolactinaemia 290.44 12.12 127 107995 1469 34847340
Dysarthria 289.26 12.12 441 107681 34341 34814468
Psychotic symptom 279.71 12.12 127 107995 1616 34847193
Diabetes mellitus 277.09 12.12 510 107612 46363 34802446
Tardive dyskinesia 265.03 12.12 185 107937 5605 34843204
Completed suicide 263.44 12.12 783 107339 97385 34751424
Mental impairment 258.26 12.12 231 107891 10091 34838718
Oculogyric crisis 255.90 12.12 116 108006 1470 34847339
Depressed level of consciousness 244.27 12.12 459 107663 42382 34806427
Suicidal ideation 239.38 12.12 440 107682 39948 34808861
Abnormal behaviour 238.52 12.12 338 107784 24631 34824178
Priapism 234.28 12.12 162 107960 4832 34843977
Blood prolactin abnormal 232.93 12.12 94 108028 875 34847934
Rash 231.73 12.12 209 107913 222543 34626266
Increased appetite 230.26 12.12 188 107934 7241 34841568
Dyspnoea 228.52 12.12 519 107603 376263 34472546
Restlessness 227.42 12.12 334 107788 25148 34823661
Coma 227.14 12.12 462 107660 45216 34803593
Blood triglycerides increased 222.54 12.12 246 107876 13913 34834896
Disinhibition 216.35 12.12 131 107991 3095 34845714
Treatment noncompliance 215.09 12.12 343 107779 27757 34821052
Antipsychotic drug level below therapeutic 198.55 12.12 114 108008 2433 34846376
Type 2 diabetes mellitus 197.76 12.12 246 107876 15786 34833023
Pain 196.63 12.12 206 107916 204469 34644340
Anosognosia 195.36 12.12 83 108039 890 34847919
Metabolic syndrome 194.02 12.12 98 108024 1601 34847208
Dyskinesia 193.14 12.12 289 107833 22124 34826685
Hypothermia 190.47 12.12 199 107923 10549 34838260
Blood prolactin increased 187.87 12.12 97 108025 1663 34847146
Obsessive-compulsive disorder 185.60 12.12 147 107975 5417 34843392
Fatigue 185.37 12.12 562 107560 370091 34478718
Paranoia 185.05 12.12 207 107915 11861 34836948
Confusional state 183.92 12.12 907 107215 143253 34705556
Emotional poverty 178.98 12.12 68 108054 530 34848279
Euphoric mood 171.15 12.12 141 107981 5500 34843309
Sexual dysfunction 165.52 12.12 145 107977 6158 34842651
Pruritus 165.24 12.12 119 108003 141862 34706947
Nausea 160.28 12.12 529 107593 339379 34509430
Diabetic ketoacidosis 157.48 12.12 234 107888 17798 34831011
Malignant neoplasm progression 155.85 12.12 40 108082 88006 34760803
Metabolic disorder 151.17 12.12 117 108005 4166 34844643
Rhabdomyolysis 150.88 12.12 509 107613 67654 34781155
Obesity 149.92 12.12 192 107930 12686 34836123
Serotonin syndrome 149.35 12.12 241 107881 19692 34829117
Death 147.73 12.12 682 107440 397367 34451442
Cough 147.61 12.12 148 107974 149992 34698817
Anaemia 147.16 12.12 314 107808 233021 34615788
Pneumonia 145.64 12.12 603 107519 362024 34486785
Disorientation 145.57 12.12 319 107803 32869 34815940
Disturbance in social behaviour 144.69 12.12 83 108039 1768 34847041
Thinking abnormal 143.03 12.12 132 107990 6005 34842804
Psychomotor hyperactivity 135.60 12.12 158 107964 9464 34839345
Therapeutic product effect variable 132.75 12.12 87 108035 2369 34846440
Tremor 132.30 12.12 556 107566 82031 34766778
Pain in extremity 132.19 12.12 118 108004 126395 34722414
Acute kidney injury 132.02 12.12 492 107630 304496 34544313
Polydipsia 131.79 12.12 104 108018 3811 34844998
Schizoaffective disorder 124.23 12.12 67 108055 1260 34847549
Anticholinergic syndrome 124.21 12.12 66 108056 1203 34847606
Irritability 122.99 12.12 250 107872 24440 34824369
Leukopenia 119.87 12.12 447 107675 62409 34786400
Disease progression 116.29 12.12 98 108024 107979 34740830
Cardiac failure congestive 116.29 12.12 56 108066 83214 34765595
Atrial fibrillation 115.35 12.12 125 107997 122268 34726541
Diabetic coma 113.89 12.12 56 108066 861 34847948
Speech disorder 112.75 12.12 247 107875 25439 34823370
Negativism 112.40 12.12 44 108078 375 34848434
Back pain 110.82 12.12 128 107994 121661 34727148
Drug interaction 110.79 12.12 1126 106996 224820 34623989
Delusional disorder, persecutory type 109.45 12.12 40 108082 276 34848533
Miosis 109.17 12.12 141 107981 9394 34839415
Dyslipidaemia 108.94 12.12 125 107997 7363 34841446
Mental disorder 107.33 12.12 179 107943 15030 34833779
Infusion related reaction 106.42 12.12 18 108104 53039 34795770
Joint swelling 106.36 12.12 27 108095 59863 34788946
Drug abuse 105.91 12.12 594 107528 98502 34750307
Urticaria 105.38 12.12 31 108091 62346 34786463
Granulocytopenia 103.00 12.12 114 108008 6453 34842356
Anxiety 102.31 12.12 590 107532 98838 34749971
Headache 102.26 12.12 301 107821 200334 34648475
Sinus tachycardia 98.87 12.12 186 107936 17174 34831635
Antipsychotic drug level increased 97.66 12.12 87 108035 3778 34845031
Rheumatoid arthritis 97.51 12.12 5 108117 38233 34810576
Neutrophil count increased 95.53 12.12 182 107940 16964 34831845
Gastrointestinal haemorrhage 94.22 12.12 81 108041 88396 34760413
Interstitial lung disease 94.09 12.12 42 108080 65240 34783569
Delusion of grandeur 93.31 12.12 53 108069 1107 34847702
Blood cholesterol increased 91.81 12.12 199 107923 20344 34828465
Peripheral swelling 87.86 12.12 65 108057 76476 34772333
Pneumonia aspiration 85.77 12.12 305 107817 41598 34807211
Faecaloma 85.47 12.12 94 108028 5283 34843526
Bradykinesia 85.46 12.12 81 108041 3812 34844997
Antipsychotic drug level above therapeutic 85.08 12.12 51 108071 1182 34847627
Apathy 84.88 12.12 106 108016 6826 34841983
Erythema 84.36 12.12 90 108032 88690 34760119
Renal impairment 84.16 12.12 101 108021 94412 34754397
Oedema peripheral 83.34 12.12 152 107970 119660 34729149
Type 1 diabetes mellitus 82.99 12.12 83 108039 4175 34844634
Dyspnoea exertional 81.84 12.12 17 108105 43262 34805547
Respiratory depression 81.50 12.12 165 107957 16080 34832729
Persecutory delusion 81.44 12.12 66 108056 2514 34846295
Psychiatric decompensation 80.00 12.12 69 108053 2868 34845941
Bradyphrenia 79.97 12.12 86 108036 4712 34844097
Decreased appetite 79.50 12.12 257 107865 166135 34682674
Prostate cancer 78.31 12.12 14 108108 39635 34809174
Hypomania 77.98 12.12 62 108060 2297 34846512
Social avoidant behaviour 76.51 12.12 69 108053 3045 34845764
Drug hypersensitivity 76.10 12.12 82 108040 80447 34768362
Agranulocytosis 75.48 12.12 202 107920 23619 34825190
White blood cell count increased 75.39 12.12 289 107833 40862 34807947
Hallucination 74.98 12.12 337 107785 51161 34797648
Poisoning deliberate 74.59 12.12 106 108016 7738 34841071
Renal failure 73.07 12.12 187 107935 130370 34718439
Psychiatric symptom 71.28 12.12 70 108052 3443 34845366
Sedation complication 70.36 12.12 52 108070 1725 34847084
Hallucination, visual 70.18 12.12 164 107958 17627 34831182
Weight decreased 69.97 12.12 294 107828 176007 34672802
Heat stroke 69.41 12.12 41 108081 924 34847885
Paradoxical drug reaction 68.42 12.12 67 108055 3284 34845525
Hyperammonaemia 68 12.12 91 108031 6276 34842533
Drug ineffective 66.67 12.12 1865 106257 454886 34393923
Drooling 66.05 12.12 66 108056 3316 34845493
Sepsis 65.94 12.12 278 107844 166283 34682526
COVID-19 65.76 12.12 86 108036 77464 34771345
Ascites 65.48 12.12 31 108091 46540 34802269
Influenza 65.45 12.12 36 108086 49630 34799179
Nasopharyngitis 65.27 12.12 72 108050 69896 34778913
Bipolar disorder 65.11 12.12 68 108054 3601 34845208
Loss of consciousness 64.85 12.12 458 107664 82209 34766600
Intentional product use issue 64.59 12.12 54 108068 59762 34789047
Infection 64.40 12.12 114 108008 90801 34758008
Neuropathy peripheral 63.05 12.12 100 108022 83163 34765646
Thrombosis 63.05 12.12 39 108083 50419 34798390
Hepatic steatosis 62.56 12.12 160 107962 18202 34830607
Haemorrhage 62.41 12.12 41 108081 51329 34797480
Abdominal pain 62.38 12.12 277 107845 163341 34685468
Herpes zoster 62.05 12.12 15 108107 34384 34814425
Withdrawal syndrome 61.87 12.12 126 107996 12329 34836480
Self-injurious ideation 61.61 12.12 47 108075 1637 34847172
International normalised ratio increased 61.36 12.12 35 108087 47292 34801517
Obsessive-compulsive symptom 61.24 12.12 21 108101 117 34848692
Tension 61.08 12.12 52 108070 2123 34846686
Pleurothotonus 61.05 12.12 41 108081 1164 34847645
Psoriasis 60.76 12.12 22 108100 38790 34810019
Asthenia 60.65 12.12 477 107645 244774 34604035
Eosinophilic myocarditis 60.58 12.12 31 108091 521 34848288
Product dose omission issue 59.17 12.12 182 107940 119529 34729280
Arthropathy 58.92 12.12 7 108115 26900 34821909
Altered state of consciousness 58.80 12.12 180 107942 22713 34826096
Unresponsive to stimuli 58.41 12.12 203 107919 27366 34821443
Blepharospasm 58.33 12.12 39 108083 1099 34847710
Abdominal discomfort 57.56 12.12 60 108062 59775 34789034
Stomatitis 57.21 12.12 30 108092 42484 34806325
Obsessive thoughts 56.74 12.12 33 108089 722 34848087
Megacolon 56.49 12.12 46 108076 1764 34847045
Troponin increased 56.32 12.12 115 108007 11274 34837535
Asthma 56.08 12.12 31 108091 42625 34806184
Disturbance in attention 55.80 12.12 192 107930 25753 34823056
Hyperkalaemia 55.76 12.12 80 108042 69309 34779500
Overweight 54.75 12.12 46 108076 1844 34846965
Plasma cell myeloma 54.62 12.12 31 108091 42006 34806803
Sinusitis 54.56 12.12 30 108092 41372 34807437
Cognitive disorder 52.95 12.12 202 107920 28491 34820318
Water intoxication 52.74 12.12 26 108096 402 34848407
Septic shock 51.84 12.12 89 108033 71745 34777064
Cerebrovascular accident 51.77 12.12 116 108006 84695 34764114
Rebound psychosis 51.65 12.12 20 108102 165 34848644
Hypertriglyceridaemia 51.22 12.12 93 108029 8355 34840454
Inappropriate affect 50.91 12.12 30 108092 673 34848136
Affective disorder 50.73 12.12 65 108057 4295 34844514
Productive cough 50.41 12.12 27 108095 37786 34811023
Arthritis 50.39 12.12 17 108105 31329 34817480
Sudden death 50.28 12.12 131 107991 15070 34833739
Stupor 50.27 12.12 53 108069 2838 34845971
Feeling guilty 50.14 12.12 23 108099 300 34848509
Cytomegalovirus infection 49.96 12.12 10 108112 26125 34822684
Accidental death 49.95 12.12 49 108073 2407 34846402
Hallucinations, mixed 49.82 12.12 51 108071 2638 34846171
Personality change 49.68 12.12 70 108052 5069 34843740
Delusion of replacement 49.40 12.12 18 108104 123 34848686
Pleural effusion 49.39 12.12 112 108010 81434 34767375
Refusal of treatment by patient 49.33 12.12 69 108053 4963 34843846
Hyperreflexia 49.15 12.12 55 108067 3151 34845658
Melaena 49.05 12.12 24 108098 35356 34813453
Febrile neutropenia 48.99 12.12 237 107885 136612 34712197
Hyponatraemia 48.78 12.12 429 107693 82262 34766547
Visceral congestion 48.57 12.12 28 108094 602 34848207
Poisoning 48.54 12.12 113 108009 12113 34836696
Cardiomyopathy 47.77 12.12 137 107985 16671 34832138
Wheezing 47.70 12.12 35 108087 41367 34807442
Injection site pain 47.56 12.12 31 108091 38974 34809835
Haematuria 47.26 12.12 51 108071 50015 34798794
Mutism 46.66 12.12 31 108091 864 34847945
Haematochezia 46.66 12.12 45 108077 46489 34802320
Insomnia 46.59 12.12 509 107613 103398 34745411
Psoriatic arthropathy 46.34 12.12 4 108118 19794 34829015
Chronic kidney disease 45.99 12.12 36 108086 41174 34807635
Cogwheel rigidity 45.69 12.12 36 108086 1316 34847493
Aspiration 45.48 12.12 110 108012 12084 34836725
Coma scale abnormal 45.45 12.12 59 108063 3949 34844860
Multiple drug therapy 45.19 12.12 24 108098 437 34848372
Antisocial behaviour 45.08 12.12 23 108099 384 34848425
Anaphylactic reaction 44.65 12.12 22 108100 32279 34816530
Hypersensitivity 44.61 12.12 75 108047 60960 34787849
Mydriasis 44.29 12.12 80 108042 7157 34841652
General physical health deterioration 44.26 12.12 225 107897 128044 34720765
Angina pectoris 43.90 12.12 21 108101 31342 34817467
Grandiosity 43.65 12.12 21 108101 307 34848502
Psychomotor retardation 43.39 12.12 55 108067 3595 34845214
Intestinal pseudo-obstruction 43.32 12.12 39 108083 1717 34847092
Myocardial infarction 43.15 12.12 210 107912 120875 34727934
Logorrhoea 43.12 12.12 45 108077 2381 34846428
Suspiciousness 42.99 12.12 21 108101 318 34848491
Sexually inappropriate behaviour 42.83 12.12 24 108098 488 34848321
Haemoglobin decreased 42.73 12.12 210 107912 120562 34728247
Swelling 42.44 12.12 41 108081 42325 34806484
Gout 42.18 12.12 5 108117 19248 34829561
Derealisation 41.99 12.12 25 108097 572 34848237
Multiple organ dysfunction syndrome 41.78 12.12 111 108011 76455 34772354
Blood creatinine increased 41.70 12.12 152 107970 94824 34753985
Chills 41.62 12.12 121 108001 80922 34767887
Ileus paralytic 41.53 12.12 70 108052 5927 34842882
Nephrolithiasis 41.41 12.12 21 108101 30312 34818497
Inappropriate antidiuretic hormone secretion 41.26 12.12 109 108013 12644 34836165
Anxiolytic therapy 41.21 12.12 13 108109 53 34848756
COVID-19 pneumonia 40.91 12.12 3 108119 16964 34831845
Spasmodic dysphonia 40.87 12.12 18 108104 212 34848597
Pancreatitis necrotising 40.05 12.12 46 108076 2712 34846097
Staphylococcal infection 39.99 12.12 26 108096 32734 34816075
Xanthoma 39.69 12.12 14 108108 86 34848723
Diverticulitis 39.63 12.12 7 108115 19997 34828812
Drug therapy enhancement 39.57 12.12 13 108109 62 34848747
Autonomic nervous system imbalance 39.51 12.12 44 108078 2507 34846302
Hyperglycaemia 39.07 12.12 232 107890 39248 34809561
Bladder cancer 38.90 12.12 3 108119 16275 34832534
Neutropenia 38.84 12.12 691 107431 156087 34692722
Angioedema 38.81 12.12 35 108087 37339 34811470
Product substitution issue 38.66 12.12 92 108030 10003 34838806
Pneumonitis 38.56 12.12 29 108093 33849 34814960
Muscle spasms 38.49 12.12 112 108010 74889 34773920
Cardiac failure 38.14 12.12 149 107973 91099 34757710
Hyperthermia 37.95 12.12 94 108028 10483 34838326
Breast engorgement 37.88 12.12 9 108113 7 34848802
Candida infection 37.83 12.12 5 108117 17710 34831099
Urinary retention 37.69 12.12 216 107906 36072 34812737
Pulmonary embolism 37.66 12.12 434 107688 89312 34759497
Fluid retention 37.63 12.12 18 108104 26869 34821940
Myelosuppression 37.61 12.12 7 108115 19258 34829551
Torticollis 37.44 12.12 30 108092 1124 34847685
Urinary incontinence 37.42 12.12 136 107986 18738 34830071
Colitis 37.27 12.12 37 108085 37713 34811096
Musculoskeletal pain 36.84 12.12 27 108095 31936 34816873
Hypervolaemia 36.73 12.12 8 108114 19701 34829108
Muscular weakness 36.58 12.12 110 108012 72787 34776022
Full blood count decreased 36.56 12.12 6 108116 18082 34830727
Mental status changes 36.54 12.12 222 107900 37861 34810948
Food craving 36.45 12.12 21 108101 451 34848358
Chest discomfort 36.28 12.12 71 108051 54459 34794350
Neutrophil count decreased 35.97 12.12 276 107846 50828 34797981
Skin exfoliation 35.96 12.12 20 108102 27412 34821397
Blood glucose increased 35.71 12.12 339 107783 66379 34782430
Pancytopenia 35.68 12.12 162 107960 94995 34753814
Hanging 35.45 12.12 15 108107 159 34848650
Epistaxis 35.27 12.12 80 108042 58171 34790638
Eye movement disorder 35.22 12.12 53 108069 4074 34844735
Electrocardiogram abnormal 35.12 12.12 84 108038 9163 34839646
Diabetic hyperosmolar coma 34.74 12.12 20 108102 429 34848380
Prostatic specific antigen increased 34.26 12.12 3 108119 14677 34834132
Antipsychotic drug level decreased 34.19 12.12 27 108095 990 34847819
Hypertonia 34.08 12.12 53 108069 4193 34844616
Bronchitis 34.08 12.12 48 108074 41915 34806894
Hyperphagia 33.92 12.12 31 108091 1392 34847417
Eosinophil count decreased 33.83 12.12 31 108091 1397 34847412
Rebound effect 33.75 12.12 46 108076 3228 34845581
Enuresis 33.75 12.12 39 108083 2314 34846495
Flat affect 33.57 12.12 25 108097 839 34847970
Osteoarthritis 33.51 12.12 11 108111 20631 34828178
Cold-stimulus headache 33.47 12.12 7 108115 0 34848809
Physical assault 33.44 12.12 28 108094 1117 34847692
Depressed mood 33.20 12.12 133 107989 19184 34829625
Acute myocardial infarction 33.15 12.12 73 108049 53646 34795163
Erectile dysfunction 33.03 12.12 139 107983 20498 34828311
Myalgia 32.86 12.12 141 107981 83969 34764840
Hyperglycaemic hyperosmolar nonketotic syndrome 32.71 12.12 29 108093 1251 34847558
Generalised tonic-clonic seizure 32.64 12.12 141 107981 21033 34827776
Seizure 32.62 12.12 480 107642 104377 34744432
Delusional disorder, unspecified type 32.50 12.12 23 108099 712 34848097
Dysgeusia 32.38 12.12 21 108101 26476 34822333
Behaviour disorder 32.27 12.12 56 108066 4854 34843955
Posture abnormal 31.93 12.12 37 108085 2202 34846607
Fever neonatal 31.80 12.12 8 108114 10 34848799
Oral discharge 31.66 12.12 13 108109 127 34848682
Hyperlipidaemia 31.66 12.12 108 108014 14421 34834388
Selective eating disorder 31.64 12.12 33 108089 1745 34847064
Myelodysplastic syndrome 31.60 12.12 10 108112 19198 34829611
Thrombocytopenia 31.47 12.12 320 107802 155927 34692882
Asphyxia 31.43 12.12 67 108055 6768 34842041
Judgement impaired 31.43 12.12 21 108101 591 34848218
Chronic obstructive pulmonary disease 31.42 12.12 65 108057 48853 34799956
Long QT syndrome 31.38 12.12 41 108081 2762 34846047
Pulmonary fibrosis 31.31 12.12 9 108113 18387 34830422
Withdrawal catatonia 31.31 12.12 12 108110 96 34848713
Impulsive behaviour 31.29 12.12 36 108086 2126 34846683
Therapeutic product effect incomplete 31.25 12.12 265 107857 50276 34798533
Coronary artery disease 31.18 12.12 64 108058 48241 34800568
Encephalitis toxic 31.10 12.12 16 108106 272 34848537
Bipolar I disorder 31.09 12.12 23 108099 764 34848045
Peptostreptococcus infection 30.89 12.12 9 108113 26 34848783
Upper respiratory tract infection 30.84 12.12 34 108088 33025 34815784
Depressive symptom 30.74 12.12 41 108081 2818 34845991
Dysphonia 30.72 12.12 17 108105 23366 34825443
Eosinophil count increased 30.56 12.12 76 108046 8496 34840313
Reduced facial expression 30.47 12.12 26 108096 1065 34847744
Pressure of speech 30.38 12.12 19 108103 476 34848333
Abdominal pain upper 30.34 12.12 116 108006 71374 34777435
Iatrogenic injury 30.23 12.12 24 108098 887 34847922
Retrograde ejaculation 30.11 12.12 18 108104 415 34848394
Hyperhidrosis 29.96 12.12 362 107760 75330 34773479
Substance abuse 29.65 12.12 70 108052 7571 34841238
Leukaemia 29.60 12.12 52 108070 4551 34844258
Leukocytosis 29.57 12.12 150 107972 23915 34824894
Rash pruritic 29.47 12.12 24 108098 26917 34821892
Skin ulcer 29.41 12.12 16 108106 22200 34826609
Hypometabolism 29.33 12.12 12 108110 116 34848693
Staring 29.28 12.12 29 108093 1441 34847368
Rhinorrhoea 29.17 12.12 22 108100 25646 34823163
Somatic symptom disorder 29.12 12.12 21 108101 670 34848139
Hyperbilirubinaemia 29.12 12.12 8 108114 16835 34831974
White blood cell count decreased 28.93 12.12 435 107687 95010 34753799
Metastases to liver 28.84 12.12 4 108118 13659 34835150
Paradoxical embolism 28.69 12.12 6 108116 0 34848809
Wrong patient received product 28.44 12.12 38 108084 2616 34846193
Urinary tract infection 28.13 12.12 149 107973 83932 34764877
Dysphagia 28.13 12.12 306 107816 62075 34786734
Colitis ischaemic 28.10 12.12 62 108060 6413 34842396
Brain injury 28.01 12.12 60 108062 6082 34842727
Blunted affect 27.76 12.12 16 108106 344 34848465
Unevaluable event 27.75 12.12 36 108086 32554 34816255
Cerebrovascular stenosis 27.67 12.12 11 108111 98 34848711
Waxy flexibility 27.39 12.12 11 108111 101 34848708
Ketoacidosis 27.38 12.12 48 108074 4195 34844614
Protrusion tongue 27.27 12.12 13 108109 186 34848623
Bronchopulmonary aspergillosis 27.21 12.12 6 108116 14653 34834156
Perseveration 27.20 12.12 11 108111 103 34848706
Dehydration 27.07 12.12 264 107858 129705 34719104
Painful erection 27.06 12.12 14 108108 241 34848568
Agitated depression 27.06 12.12 14 108108 241 34848568
Somnambulism 27.00 12.12 40 108082 3032 34845777
Hospitalisation 26.99 12.12 282 107840 56620 34792189
Incoherent 26.97 12.12 49 108073 4403 34844406
Proteinuria 26.83 12.12 12 108110 18630 34830179
Fungal infection 26.75 12.12 8 108114 15927 34832882
Drug level increased 26.64 12.12 137 107985 21959 34826850
Osteonecrosis of jaw 26.57 12.12 11 108111 17878 34830931
Pulmonary mass 26.46 12.12 4 108118 12808 34836001
Neuralgia 26.46 12.12 7 108115 15106 34833703
Hunger 26.43 12.12 29 108093 1625 34847184
Psychotic behaviour 26.40 12.12 20 108102 689 34848120
Blood pressure increased 26.31 12.12 162 107960 87940 34760869
Camptocormia 26.26 12.12 12 108110 155 34848654
Dementia with Lewy bodies 26.25 12.12 20 108102 695 34848114
Gastrointestinal sounds abnormal 26.21 12.12 33 108089 2142 34846667
Depression 26.20 12.12 434 107688 96664 34752145
Gynaecomastia 26.09 12.12 80 108042 10100 34838709
Drug withdrawal syndrome neonatal 26.07 12.12 43 108079 3576 34845233
Respiratory arrest 25.97 12.12 162 107960 27881 34820928
Oedema 25.95 12.12 65 108057 45676 34803133
Ataxia 25.94 12.12 98 108024 13755 34835054
Electroencephalogram abnormal 25.82 12.12 35 108087 2443 34846366
Snoring 25.80 12.12 41 108081 3305 34845504
Illusion 25.77 12.12 21 108101 806 34848003
Flatulence 25.63 12.12 17 108105 21181 34827628
Illness anxiety disorder 25.60 12.12 12 108110 165 34848644
Affect lability 25.51 12.12 43 108079 3640 34845169
Inflammation 25.41 12.12 30 108092 28265 34820544
Contusion 25.37 12.12 46 108076 36318 34812491
Tachyphrenia 25.22 12.12 25 108097 1244 34847565
Dry skin 25.19 12.12 36 108086 31251 34817558
Laboratory test abnormal 25.13 12.12 16 108106 20375 34828434
Panic attack 25.00 12.12 75 108047 9357 34839452
Alcohol use 24.95 12.12 40 108082 3248 34845561
Injection site erythema 24.90 12.12 9 108113 15890 34832919
Major depression 24.81 12.12 48 108074 4524 34844285
Abulia 24.75 12.12 18 108104 582 34848227
Dysphoria 24.73 12.12 33 108089 2269 34846540
Malignant catatonia 24.66 12.12 13 108109 233 34848576
Drug withdrawal syndrome 24.63 12.12 124 107998 19710 34829099
Bone pain 24.46 12.12 17 108105 20669 34828140
High density lipoprotein decreased 24.31 12.12 40 108082 3320 34845489
Blister 24.22 12.12 21 108101 22837 34825972
Frequent bowel movements 24.22 12.12 5 108117 12782 34836027
Ejaculation disorder 24.09 12.12 22 108100 987 34847822
Osteonecrosis 24.06 12.12 8 108114 14882 34833927
Exhibitionism 24.04 12.12 8 108114 40 34848769
Neoplasm malignant 24.02 12.12 16 108106 19889 34828920
Motor dysfunction 23.99 12.12 61 108061 6913 34841896
Neoplasm progression 23.97 12.12 22 108100 23278 34825531
Tubulointerstitial nephritis 23.92 12.12 18 108104 21006 34827803
Osteomyelitis 23.84 12.12 10 108112 16126 34832683
Haemoptysis 23.78 12.12 45 108077 34961 34813848
Aspartate aminotransferase increased 23.77 12.12 317 107805 67466 34781343
Hypercholesterolaemia 23.53 12.12 70 108052 8692 34840117
Suicidal behaviour 23.50 12.12 26 108096 1471 34847338
Rhinalgia 23.28 12.12 22 108100 1031 34847778
Haematoma 23.15 12.12 27 108095 25578 34823231
Choreoathetosis 23.09 12.12 22 108100 1042 34847767
Pyrexia 23.01 12.12 821 107301 332192 34516617
Transient ischaemic attack 23.00 12.12 31 108091 27582 34821227
Rectal haemorrhage 22.98 12.12 57 108065 40192 34808617
Gastrointestinal hypomotility 22.93 12.12 22 108100 1051 34847758
Hypoaesthesia 22.78 12.12 105 108017 61339 34787470
Resting tremor 22.70 12.12 18 108104 664 34848145
Restless legs syndrome 22.69 12.12 67 108055 8287 34840522
Delusional perception 22.67 12.12 11 108111 164 34848645
Myoclonus 22.65 12.12 98 108024 14627 34834182
Hepatitis C virus test positive 22.59 12.12 14 108108 345 34848464
Agitation neonatal 22.54 12.12 22 108100 1074 34847735
Troponin I increased 22.26 12.12 34 108088 2648 34846161
Disorganised speech 22.13 12.12 20 108102 885 34847924
Patient restraint 22.09 12.12 9 108113 86 34848723
Galactorrhoea 22.05 12.12 15 108107 435 34848374
Cerebral haemorrhage 21.95 12.12 47 108075 34890 34813919
Impaired healing 21.87 12.12 10 108112 15324 34833485
Compulsive sexual behaviour 21.63 12.12 12 108110 239 34848570
Red cell distribution width decreased 21.49 12.12 11 108111 185 34848624
Alanine aminotransferase increased 21.35 12.12 360 107762 80455 34768354
Clostridium difficile colitis 21.31 12.12 11 108111 15719 34833090
Confabulation 21.30 12.12 10 108112 138 34848671
Lipids increased 21.28 12.12 21 108101 1039 34847770
Cataract 21.21 12.12 30 108092 26156 34822653
Somatic hallucination 21.20 12.12 7 108115 34 34848775
Intentional product misuse 21.14 12.12 225 107897 45386 34803423
Epilepsy 21.06 12.12 126 107996 21369 34827440
Hallucination, olfactory 20.97 12.12 11 108111 195 34848614
Hypomagnesaemia 20.90 12.12 22 108100 21829 34826980
Upper gastrointestinal haemorrhage 20.90 12.12 29 108093 25489 34823320
Cerebellar syndrome 20.86 12.12 31 108091 2357 34846452
Rash erythematous 20.85 12.12 28 108094 24949 34823860
Renal disorder 20.83 12.12 29 108093 25451 34823358
Condition aggravated 20.80 12.12 758 107364 191438 34657371
Squamous cell carcinoma 20.70 12.12 5 108117 11470 34837339
Obsessive-compulsive personality disorder 20.68 12.12 10 108112 148 34848661
Pancreatitis haemorrhagic 20.67 12.12 13 108109 329 34848480
Gamma-glutamyltransferase increased 20.63 12.12 158 107964 29073 34819736
Appendicitis 20.59 12.12 10 108112 14797 34834012
Bone marrow failure 20.41 12.12 37 108085 29216 34819593
Adrenal insufficiency 20.28 12.12 9 108113 14038 34834771
Drug level below therapeutic 20.24 12.12 50 108072 5565 34843244
Blood creatine phosphokinase MB increased 20.21 12.12 27 108095 1859 34846950
Mixed delusion 20.12 12.12 7 108115 41 34848768
Skin lesion 20.03 12.12 23 108099 21938 34826871
Blood bilirubin increased 19.78 12.12 57 108065 38239 34810570
Total cholesterol/HDL ratio increased 19.76 12.12 10 108112 164 34848645
Wrong technique in product usage process 19.75 12.12 52 108070 35934 34812875
Tongue movement disturbance 19.72 12.12 9 108113 116 34848693
Heart rate decreased 19.70 12.12 43 108079 31702 34817107
Paraesthesia 19.68 12.12 117 108005 64055 34784754
Symptom masked 19.48 12.12 16 108106 621 34848188
Blood urea decreased 19.46 12.12 20 108102 1039 34847770
Impaired self-care 19.44 12.12 22 108100 1276 34847533
Blood ketone body 19.41 12.12 8 108114 79 34848730
Echolalia 19.35 12.12 12 108110 296 34848513
Alcohol abuse 19.33 12.12 44 108078 4646 34844163
Compartment syndrome 19.29 12.12 34 108088 2984 34845825
Faeces discoloured 19.28 12.12 11 108111 14867 34833942
Off label use 19.21 12.12 1082 107040 418442 34430367
Acute psychosis 19.16 12.12 26 108096 1817 34846992
Illiteracy 19.16 12.12 5 108117 8 34848801
Intravascular papillary endothelial hyperplasia 19.13 12.12 4 108118 0 34848809
Blood thrombin increased 19.13 12.12 4 108118 0 34848809
Histrionic personality disorder 19.13 12.12 4 108118 0 34848809
Hyperchylomicronaemia 19.13 12.12 4 108118 0 34848809
Drug monitoring procedure incorrectly performed 19.10 12.12 11 108111 236 34848573
Gaze palsy 19.10 12.12 25 108097 1687 34847122
Acute myeloid leukaemia 19.10 12.12 17 108105 18253 34830556
Pulmonary hypertension 18.99 12.12 22 108100 20902 34827907
Anger 18.98 12.12 80 108042 11804 34837005
Injection site swelling 18.97 12.12 6 108116 11521 34837288
Clonus 18.91 12.12 32 108090 2718 34846091
Salivary gland calculus 18.81 12.12 8 108114 86 34848723
Product use issue 18.47 12.12 117 108005 63099 34785710
Chromaturia 18.44 12.12 11 108111 14509 34834300
Metastases to bone 18.37 12.12 7 108115 11963 34836846
Oromandibular dystonia 18.37 12.12 14 108108 487 34848322
Night sweats 18.31 12.12 16 108106 17336 34831473
Eczema 18.27 12.12 18 108104 18418 34830391
Homicidal ideation 18.17 12.12 31 108091 2651 34846158
Hepatic failure 18.12 12.12 51 108071 34480 34814329
Clostridium difficile infection 18.11 12.12 19 108103 18879 34829930
Abnormal weight gain 18.06 12.12 19 108103 1015 34847794
Soliloquy 18.05 12.12 13 108109 414 34848395
Respiration abnormal 18.04 12.12 34 108088 3142 34845667
Cholestasis 17.99 12.12 35 108087 26913 34821896
Cardio-respiratory arrest 17.95 12.12 255 107867 55018 34793791
Electrocardiogram QT shortened 17.93 12.12 9 108113 145 34848664
Personality disorder 17.84 12.12 20 108102 1148 34847661
Pain in jaw 17.84 12.12 9 108113 13031 34835778
Bacteraemia 17.60 12.12 21 108101 19696 34829113
Aplastic anaemia 17.59 12.12 68 108054 9648 34839161
Globulins decreased 17.56 12.12 10 108112 210 34848599
Pulmonary arterial hypertension 17.44 12.12 3 108119 8736 34840073
Ear infection 17.42 12.12 5 108117 10226 34838583
Cardiogenic shock 17.40 12.12 35 108087 26583 34822226
Hostility 17.40 12.12 17 108105 831 34847978
Visual impairment 17.26 12.12 55 108067 35747 34813062
Injection site bruising 17.23 12.12 3 108119 8660 34840149
Asocial behaviour 17.17 12.12 7 108115 67 34848742
Hypotonia neonatal 17.16 12.12 21 108101 1324 34847485
Hyperarousal 17.13 12.12 6 108116 36 34848773
Palmar-plantar erythrodysaesthesia syndrome 17.11 12.12 16 108106 16779 34832030
Stereotypy 17.07 12.12 16 108106 742 34848067
Eosinophilia 17.00 12.12 139 107983 26083 34822726
Neurodegenerative disorder 16.98 12.12 10 108112 224 34848585
Osteoporosis 16.95 12.12 9 108113 12659 34836150
C-reactive protein increased 16.94 12.12 248 107874 53850 34794959
Lung disorder 16.94 12.12 53 108069 34643 34814166
Flushing 16.93 12.12 48 108074 32372 34816437
Polydipsia psychogenic 16.87 12.12 8 108114 113 34848696
Negative symptoms in schizophrenia 16.85 12.12 6 108116 38 34848771
Hypokinesia 16.77 12.12 63 108059 8817 34839992
Labelled drug-drug interaction medication error 16.73 12.12 13 108109 14926 34833883
Coagulopathy 16.70 12.12 22 108100 19767 34829042
Embolism venous 16.70 12.12 22 108100 1494 34847315
Lymphocyte count increased 16.66 12.12 34 108088 3331 34845478
Wound 16.56 12.12 13 108109 14851 34833958
Neglect of personal appearance 16.50 12.12 8 108114 119 34848690
Tangentiality 16.50 12.12 8 108114 119 34848690
Localised infection 16.50 12.12 18 108104 17569 34831240
Left ventricular dysfunction 16.48 12.12 68 108054 9939 34838870
Paraphilia 16.48 12.12 7 108115 75 34848734
Anaphylactic shock 16.46 12.12 15 108107 15926 34832883
Blood ethanol 16.44 12.12 8 108114 120 34848689
Dizziness 16.39 12.12 533 107589 217988 34630821
Bezoar 16.30 12.12 19 108103 1138 34847671
Depersonalisation/derealisation disorder 16.27 12.12 14 108108 580 34848229
Surgery 16.26 12.12 12 108110 14145 34834664
Pulmonary valve incompetence 16.25 12.12 17 108105 902 34847907
Hepatic cancer 16.17 12.12 3 108119 8272 34840537
Hyperosmolar state 16.16 12.12 12 108110 401 34848408
Autoscopy 16.12 12.12 10 108112 247 34848562
Myotonia 16.11 12.12 6 108116 44 34848765
Vascular stenosis 16.06 12.12 9 108113 183 34848626
Blood pressure systolic increased 16.04 12.12 29 108093 22923 34825886
Angina unstable 16.00 12.12 8 108114 11645 34837164
Parkinsonian rest tremor 15.98 12.12 8 108114 128 34848681
Blood loss anaemia 15.95 12.12 3 108119 8191 34840618
Blood creatine phosphokinase decreased 15.93 12.12 13 108109 500 34848309
Hyperammonaemic encephalopathy 15.92 12.12 27 108095 2297 34846512
Drug eruption 15.91 12.12 23 108099 19875 34828934
Feeling hot 15.88 12.12 22 108100 19350 34829459
Ageusia 15.86 12.12 6 108116 10302 34838507
Pancreatic carcinoma 15.82 12.12 4 108118 8897 34839912
Sluggishness 15.82 12.12 33 108089 3284 34845525
Cardiac dysfunction 15.80 12.12 27 108095 2311 34846498
Device related infection 15.78 12.12 18 108104 17219 34831590
Lymphocyte count abnormal 15.77 12.12 19 108103 1179 34847630
Gastric haemorrhage 15.75 12.12 6 108116 10255 34838554
Malaise 15.72 12.12 446 107676 185379 34663430
Porphyria acute 15.67 12.12 11 108111 336 34848473
Cyclothymic disorder 15.63 12.12 7 108115 86 34848723
Tic 15.57 12.12 25 108097 2033 34846776
Troponin T increased 15.53 12.12 27 108095 2344 34846465
Polyuria 15.51 12.12 60 108062 8514 34840295
Pathogen resistance 15.49 12.12 5 108117 9477 34839332
Dermatitis 15.45 12.12 5 108117 9463 34839346
Gastrointestinal hypermotility 15.45 12.12 8 108114 138 34848671
Homosexuality 15.44 12.12 6 108116 50 34848759
Toxic epidermal necrolysis 15.44 12.12 27 108095 21619 34827190
Drug level above therapeutic 15.42 12.12 38 108084 4223 34844586
Cor pulmonale acute 15.40 12.12 10 108112 268 34848541
Nasal congestion 15.35 12.12 30 108092 23027 34825782
Pneumothorax 15.34 12.12 22 108100 19070 34829739
Multiple sclerosis relapse 15.25 12.12 11 108111 13122 34835687
Body temperature increased 15.25 12.12 99 108023 17269 34831540
Large intestine polyp 15.18 12.12 3 108119 7911 34840898
Gastrectomy 15.14 12.12 8 108114 144 34848665
Contraindicated product administered 15.14 12.12 27 108095 21454 34827355
Circadian rhythm sleep disorder 15.03 12.12 12 108110 447 34848362
Hypersomnia 15.01 12.12 77 108045 12330 34836479
Transfusion 14.98 12.12 4 108118 8581 34840228
Posterior reversible encephalopathy syndrome 14.98 12.12 6 108116 9948 34838861
Glassy eyes 14.95 12.12 7 108115 96 34848713
Benign ethnic neutropenia 14.95 12.12 6 108116 55 34848754
Thirst 14.90 12.12 56 108066 7839 34840970
Drowning 14.90 12.12 12 108110 453 34848356
Haemophagocytic lymphohistiocytosis 14.89 12.12 11 108111 12962 34835847
Somatic delusion 14.88 12.12 7 108115 97 34848712
Therapeutic response changed 14.87 12.12 12 108110 454 34848355
Congenital megaureter 14.85 12.12 8 108114 150 34848659
Dissociative disorder 14.81 12.12 12 108110 457 34848352
Hypogammaglobulinaemia 14.71 12.12 3 108119 7737 34841072
Bronchiectasis 14.60 12.12 6 108116 9795 34839014
Oliguria 14.45 12.12 4 108118 8376 34840433
Strabismus congenital 14.41 12.12 5 108117 29 34848780
Hyperinsulinism 14.40 12.12 6 108116 61 34848748
Psychosexual disorder 14.39 12.12 7 108115 105 34848704
Eating disorder 14.37 12.12 57 108065 8183 34840626
Blood sodium increased 14.37 12.12 29 108093 2819 34845990
Tumour lysis syndrome 14.36 12.12 19 108103 17040 34831769
Schizoid personality disorder 14.35 12.12 3 108119 0 34848809
Chylomicron increased 14.35 12.12 3 108119 0 34848809
Lipomeningocele 14.35 12.12 3 108119 0 34848809
Hepatitis viral 14.29 12.12 13 108109 580 34848229
Consciousness fluctuating 14.29 12.12 18 108104 1169 34847640
Tricuspid valve sclerosis 14.27 12.12 5 108117 30 34848779
Tremor neonatal 14.22 12.12 11 108111 391 34848418
Encephalitis autoimmune 14.21 12.12 14 108108 691 34848118
Movement disorder 14.11 12.12 75 108047 12173 34836636
Body mass index increased 14.07 12.12 17 108105 1058 34847751
Basophil count decreased 14.04 12.12 7 108115 111 34848698
Eye pruritus 14.03 12.12 3 108119 7486 34841323
Mobility decreased 14.03 12.12 47 108075 30081 34818728
Disseminated intravascular coagulation 13.99 12.12 29 108093 21787 34827022
Hypersexuality 13.94 12.12 20 108102 1473 34847336
Skin discolouration 13.91 12.12 21 108101 17824 34830985
Shock haemorrhagic 13.87 12.12 9 108113 11345 34837464
Abdominal distension 13.83 12.12 115 108007 58377 34790432
Dextrocardia 13.82 12.12 7 108115 115 34848694
Head banging 13.80 12.12 8 108114 174 34848635
Legal problem 13.80 12.12 8 108114 174 34848635
Gastric disorder 13.71 12.12 11 108111 12430 34836379
Renal tubular necrosis 13.68 12.12 17 108105 15663 34833146
Illness 13.65 12.12 13 108109 13516 34835293
Secondary tic 13.62 12.12 4 108118 12 34848797
Intercepted product prescribing error 13.61 12.12 7 108115 119 34848690
Selective mutism 13.60 12.12 6 108116 71 34848738
Abscess 13.59 12.12 10 108112 11807 34837002
Pseudomonas infection 13.58 12.12 11 108111 12371 34836438
Thrombotic microangiopathy 13.57 12.12 8 108114 10622 34838187
Oropharyngeal pain 13.53 12.12 60 108062 35425 34813384
Dyspepsia 13.48 12.12 63 108059 36669 34812140
Graft versus host disease 13.43 12.12 8 108114 10561 34838248
Chemical poisoning 13.35 12.12 7 108115 124 34848685
Trismus 13.30 12.12 26 108096 2469 34846340
Negative thoughts 13.26 12.12 13 108109 638 34848171
Migraine 13.21 12.12 21 108101 17457 34831352
Eosinophilic pleural effusion 13.17 12.12 9 108113 263 34848546
Cerebellar atrophy 13.07 12.12 12 108110 542 34848267
Drug screen positive 13.06 12.12 34 108088 3909 34844900
Spinal compression fracture 13.03 12.12 3 108119 7113 34841696
Family stress 13.01 12.12 7 108115 131 34848678
Cystitis 12.97 12.12 7 108115 9758 34839051
Thought blocking 12.96 12.12 7 108115 132 34848677
Duodenal ulcer 12.88 12.12 8 108114 10324 34838485
Lymphadenopathy 12.85 12.12 45 108077 28418 34820391
Glycosylated haemoglobin increased 12.71 12.12 69 108053 11291 34837518
Foetal alcohol syndrome 12.68 12.12 7 108115 138 34848671
Fear 12.66 12.12 65 108057 10411 34838398
Flight of ideas 12.66 12.12 10 108112 367 34848442
Injection site reaction 12.60 12.12 13 108109 13020 34835789
Visual acuity reduced 12.59 12.12 19 108103 16130 34832679
Cataract congenital 12.58 12.12 6 108116 86 34848723
Generalised anxiety disorder 12.57 12.12 14 108108 798 34848011
Bladder dilatation 12.50 12.12 19 108103 1473 34847336
Post procedural haemorrhage 12.47 12.12 5 108117 8284 34840525
Hot flush 12.47 12.12 23 108099 18043 34830766
Pneumonia bacterial 12.46 12.12 11 108111 11861 34836948
Slow response to stimuli 12.45 12.12 14 108108 806 34848003
Vasculitis 12.43 12.12 10 108112 11286 34837523
Bacterial infection 12.43 12.12 21 108101 17042 34831767
Breath sounds abnormal 12.41 12.12 3 108119 6878 34841931
Apraxia 12.40 12.12 18 108104 1340 34847469
Deafness 12.36 12.12 10 108112 11255 34837554
Dissociation 12.35 12.12 20 108102 1638 34847171
Gambling disorder 12.33 12.12 20 108102 1640 34847169
Angle closure glaucoma 12.30 12.12 15 108107 942 34847867
Obstructive airways disorder 12.30 12.12 18 108104 15476 34833333
Inferiority complex 12.28 12.12 3 108119 3 34848806
Glutamate dehydrogenase increased 12.28 12.12 3 108119 3 34848806
Metastases to central nervous system 12.26 12.12 5 108117 8200 34840609
Hyperventilation 12.21 12.12 27 108095 2797 34846012
Velopharyngeal incompetence 12.19 12.12 4 108118 19 34848790
Acute pulmonary oedema 12.17 12.12 50 108072 7293 34841516
Accidental overdose 12.12 12.12 105 108017 20035 34828774
Throat irritation 12.12 12.12 9 108113 10576 34838233
Cellulitis 12.12 12.12 105 108017 52846 34795963

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 3287.26 11.74 1482 178205 26077 79538624
Sedation 1985.79 11.74 1314 178373 50581 79514120
Suicide attempt 1602.25 11.74 1396 178291 81536 79483165
Post-injection delirium sedation syndrome 1450.06 11.74 322 179365 263 79564438
Extrapyramidal disorder 1412.11 11.74 785 178902 21894 79542807
Agitation 1259.57 11.74 1328 178359 98387 79466314
Psychotic disorder 1253.32 11.74 908 178779 40494 79524207
Akathisia 1239.72 11.74 603 179084 12656 79552045
Sopor 1140.63 11.74 785 178902 32225 79532476
Dystonia 1066.65 11.74 641 179046 20758 79543943
Intentional overdose 1047.66 11.74 1242 178445 104718 79459983
Intentional self-injury 1020.04 11.74 728 178959 31691 79533010
Schizophrenia 1017.68 11.74 555 179132 14885 79549816
Blood prolactin abnormal 953.41 11.74 344 179343 3257 79561444
Catatonia 924.57 11.74 433 179254 8323 79556378
Overdose 916.20 11.74 1554 178133 182652 79382049
Delusion 913.76 11.74 571 179116 19852 79544849
Sexual dysfunction 894.92 11.74 408 179279 7355 79557346
Hallucination, auditory 874.41 11.74 558 179129 20135 79544566
Toxicity to various agents 852.63 11.74 2476 177211 419064 79145637
Aggression 849.72 11.74 790 178897 50168 79514533
Anosognosia 807.14 11.74 308 179379 3456 79561245
Somnolence 795.45 11.74 1699 177988 237282 79327419
Parkinsonism 760.42 11.74 471 179216 16113 79548588
Arthralgia 728.58 11.74 195 179492 571608 78993093
Disturbance in social behaviour 691.25 11.74 298 179389 4672 79560029
Dyskinesia 666.40 11.74 652 179035 44121 79520580
Electrocardiogram QT prolonged 661.80 11.74 913 178774 89473 79475228
Muscle rigidity 656.63 11.74 460 179227 19422 79545279
Completed suicide 653.35 11.74 1599 178088 244168 79320533
Metabolic disorder 650.02 11.74 346 179341 8824 79555877
Pain 643.00 11.74 397 179290 703405 78861296
Hyperprolactinaemia 626.25 11.74 273 179414 4403 79560298
Mania 599.60 11.74 421 179266 17839 79546862
Salivary hypersecretion 597.03 11.74 382 179305 13842 79550859
Drug abuse 558.53 11.74 1172 178515 161519 79403182
Blood creatine phosphokinase increased 525.40 11.74 695 178992 65395 79499306
Delirium 516.06 11.74 784 178903 83843 79480858
Tachycardia 513.50 11.74 1195 178492 176573 79388128
Suicidal ideation 508.24 11.74 737 178950 75603 79489098
Weight increased 506.33 11.74 1573 178114 275813 79288888
Tardive dyskinesia 496.73 11.74 305 179382 10266 79554435
Coma 487.71 11.74 840 178847 99809 79464892
Personality change 476.78 11.74 293 179394 9877 79554824
Drug interaction 475.26 11.74 2022 177665 413161 79151540
Depressed level of consciousness 446.63 11.74 790 178897 95862 79468839
Metabolic syndrome 433.33 11.74 180 179507 2560 79562141
Diarrhoea 427.45 11.74 838 178849 879651 78685050
Oculogyric crisis 423.69 11.74 181 179506 2771 79561930
Treatment noncompliance 419.02 11.74 552 179135 51716 79512985
Hypothermia 410.95 11.74 369 179318 22377 79542324
Abnormal behaviour 406.76 11.74 455 179232 35966 79528735
Restlessness 405.59 11.74 512 179175 45980 79518721
Rheumatoid arthritis 403.66 11.74 15 179672 208455 79356246
Myocarditis 403.41 11.74 358 179329 21375 79543326
Joint swelling 393.32 11.74 85 179602 288561 79276140
Rash 382.11 11.74 445 179242 577913 78986788
Blood prolactin increased 379.61 11.74 184 179503 3827 79560874
Infusion related reaction 369.34 11.74 43 179644 230194 79334507
Dysarthria 365.72 11.74 593 179094 67029 79497672
Psychomotor hyperactivity 364.51 11.74 303 179384 16546 79548155
Dyspnoea 361.02 11.74 882 178805 856143 78708558
Psychotic symptom 359.66 11.74 157 179530 2540 79562161
Fatigue 359.53 11.74 999 178688 928728 78635973
Headache 346.38 11.74 589 179098 653183 78911518
Hypomania 332.52 11.74 209 179478 7335 79557366
Arthropathy 328.84 11.74 17 179670 177094 79387607
Pleurothotonus 327.53 11.74 144 179543 2372 79562329
Paranoia 317.47 11.74 298 179389 19134 79545567
Pruritus 314.36 11.74 257 179430 394391 79170310
Mental impairment 311.13 11.74 292 179395 18744 79545957
Rhabdomyolysis 303.77 11.74 699 178988 102432 79462269
Tremor 294.72 11.74 948 178739 169135 79395566
Confusional state 290.84 11.74 1451 178236 316546 79248155
Drug hypersensitivity 280.01 11.74 163 179524 298753 79265948
Hallucination 279.26 11.74 605 179082 85140 79479561
Miosis 279.02 11.74 253 179434 15536 79549165
Pain in extremity 276.13 11.74 249 179438 364289 79200412
Sinusitis 273.59 11.74 54 179633 195447 79369254
Hypersensitivity 272.34 11.74 125 179562 262114 79302587
Serotonin syndrome 265.69 11.74 411 179276 44616 79520085
Nasopharyngitis 265.23 11.74 120 179567 253761 79310940
Peripheral swelling 264.12 11.74 139 179548 269478 79295223
Abdominal discomfort 261.16 11.74 119 179568 250608 79314093
Swelling 260.47 11.74 82 179605 216629 79348072
Cough 245.33 11.74 279 179408 366510 79198191
Priapism 242.83 11.74 142 179545 4363 79560338
Diabetes mellitus 242.69 11.74 542 179145 77848 79486853
Back pain 240.96 11.74 199 179488 303981 79260720
Urticaria 229.94 11.74 66 179621 185135 79379566
Prescribed overdose 226.60 11.74 348 179339 37535 79527166
Disorientation 224.20 11.74 460 179227 62316 79502385
Persecutory delusion 223.92 11.74 139 179548 4770 79559931
Social avoidant behaviour 223.87 11.74 138 179549 4676 79560025
Nausea 216.42 11.74 1270 178417 955926 78608775
Blood glucose increased 212.97 11.74 656 179031 114319 79450382
Contraindicated product administered 211.20 11.74 48 179639 157490 79407211
Antipsychotic drug level increased 206.43 11.74 142 179545 5815 79558886
Bradyphrenia 202.89 11.74 178 179509 10462 79554239
Pneumonia aspiration 202.78 11.74 459 179228 66508 79498193
Granulocytopenia 193.84 11.74 179 179508 11252 79553449
Respiratory depression 191.45 11.74 272 179415 27358 79537343
Irritability 186.95 11.74 334 179353 40810 79523891
Antipsychotic drug level above therapeutic 186.60 11.74 92 179595 1988 79562713
Leukopenia 184.37 11.74 630 179057 115883 79448818
Obsessive-compulsive disorder 183.79 11.74 132 179555 5795 79558906
Anxiety 180.96 11.74 1066 178621 247446 79317255
Polydipsia 179.82 11.74 136 179551 6469 79558232
Mental disorder 178.08 11.74 281 179406 31021 79533680
Alopecia 176.26 11.74 157 179530 231198 79333503
Negativism 175.66 11.74 68 179619 795 79563906
Increased appetite 175.45 11.74 173 179514 11805 79552896
Glossodynia 171.49 11.74 17 179670 103320 79461381
Blood triglycerides increased 171.33 11.74 224 179463 20816 79543885
Apathy 169.21 11.74 176 179511 12801 79551900
Arthritis 168.73 11.74 28 179659 114852 79449849
Injection site pain 165.38 11.74 44 179643 129794 79434907
Thinking abnormal 165.36 11.74 175 179512 12986 79551715
Drug intolerance 164.72 11.74 212 179475 263907 79300794
Obesity 163.27 11.74 288 179399 34837 79529864
Hyperthermia 159.41 11.74 200 179487 17837 79546864
Orthostatic hypertension 159.36 11.74 63 179624 782 79563919
Systemic lupus erythematosus 158.25 11.74 39 179648 121110 79443591
Camptocormia 157.39 11.74 54 179633 434 79564267
Sinus tachycardia 156.76 11.74 291 179396 36617 79528084
Emotional poverty 156.40 11.74 63 179624 824 79563877
Stomatitis 155.33 11.74 68 179619 146689 79418012
Speech disorder 148.24 11.74 358 179329 54087 79510614
Therapeutic product effect decreased 148.21 11.74 93 179594 163770 79400931
Posture abnormal 147.93 11.74 98 179589 3768 79560933
Psychomotor retardation 145.92 11.74 117 179570 6067 79558634
Infection 143.61 11.74 201 179486 241511 79323190
Schizoaffective disorder 143.54 11.74 78 179609 2074 79562627
Galactorrhoea 143.34 11.74 94 179593 3552 79561149
Psoriatic arthropathy 143.12 11.74 8 179679 77991 79486710
Psychiatric decompensation 140.95 11.74 96 179591 3867 79560834
Psychiatric symptom 140.82 11.74 121 179566 6914 79557787
Bradykinesia 140.38 11.74 128 179559 7915 79556786
Diabetic ketoacidosis 138.66 11.74 264 179423 33858 79530843
Blister 138.58 11.74 48 179639 119428 79445273
Impaired healing 136.48 11.74 18 179669 87637 79477064
Osteoarthritis 135.78 11.74 18 179669 87291 79477410
Gestational diabetes 135.75 11.74 113 179574 6180 79558521
Neutropenia 132.59 11.74 1104 178583 286606 79278095
Obsessive-compulsive symptom 131.73 11.74 38 179649 158 79564543
Pulmonary embolism 129.19 11.74 743 178944 170911 79393790
Cardio-respiratory arrest 127.10 11.74 533 179154 107977 79456724
Intentional product use issue 126.03 11.74 95 179592 152017 79412684
Disturbance in attention 125.62 11.74 322 179365 50479 79514222
Bipolar disorder 125.50 11.74 118 179569 7589 79557112
Duodenal ulcer perforation 123.97 11.74 6 179681 66205 79498496
Diabetic coma 123.26 11.74 59 179628 1192 79563509
Asthma 123.09 11.74 76 179611 135019 79429682
Product dose omission issue 122.56 11.74 232 179455 247305 79317396
Delusion of grandeur 121.54 11.74 61 179626 1371 79563330
Hallucinations, mixed 120.81 11.74 110 179577 6789 79557912
Neutrophil count increased 120.14 11.74 228 179459 29168 79535533
Disinhibition 119.60 11.74 74 179613 2524 79562177
Injection site erythema 119.52 11.74 17 179670 78180 79486521
Euphoric mood 117.67 11.74 114 179573 7612 79557089
Respiratory arrest 117.53 11.74 340 179347 57210 79507491
Mutism 115.42 11.74 70 179617 2302 79562399
Erythema 115.23 11.74 204 179483 223086 79341615
Anaemia 114.73 11.74 564 179123 444451 79120250
Unresponsive to stimuli 114.32 11.74 330 179357 55458 79509243
Hallucination, visual 113.50 11.74 237 179450 32492 79532209
Generalised tonic-clonic seizure 113.45 11.74 283 179404 43627 79521074
Obsessive thoughts 113.40 11.74 54 179633 1078 79563623
Loss of consciousness 111.74 11.74 704 178983 167239 79397462
Discomfort 111.25 11.74 73 179614 125544 79439157
Herpes zoster 110.38 11.74 36 179651 93047 79471654
Accidental death 109.45 11.74 85 179602 4206 79560495
Dyslipidaemia 109.25 11.74 133 179554 11500 79553201
Wound 109.16 11.74 63 179624 116116 79448585
Hyponatraemia 108.85 11.74 730 178957 177118 79387583
Megacolon 106.46 11.74 77 179610 3418 79561283
Cogwheel rigidity 105.56 11.74 73 179614 3015 79561686
Substance abuse 104.85 11.74 124 179563 10402 79554299
Anaphylactic reaction 103.60 11.74 30 179657 83713 79480988
Cardiac failure congestive 102.11 11.74 102 179585 142300 79422401
Mobility decreased 101.59 11.74 76 179611 122099 79442602
Influenza 101.02 11.74 86 179601 129520 79435181
Eosinophil count decreased 99.31 11.74 73 179614 3323 79561378
Chest discomfort 98.84 11.74 99 179588 137945 79426756
Cognitive disorder 98.47 11.74 364 179323 69562 79495139
Altered state of consciousness 98.41 11.74 268 179419 43554 79521147
Seizure 98.08 11.74 745 178942 188089 79376612
Jaundice cholestatic 97.93 11.74 124 179563 11160 79553541
Folliculitis 97.66 11.74 7 179680 55373 79509328
Dyspnoea exertional 97.55 11.74 37 179650 87036 79477665
Poisoning deliberate 97.52 11.74 162 179525 18666 79546035
Antipsychotic drug level below therapeutic 97.10 11.74 50 179637 1188 79563513
Drooling 96.91 11.74 91 179596 5843 79558858
Musculoskeletal pain 96.88 11.74 55 179632 102299 79462402
Inflammation 96.74 11.74 45 179642 93708 79470993
Rebound psychosis 96.27 11.74 35 179652 339 79564362
Product use issue 95.02 11.74 207 179480 209615 79355086
Interstitial lung disease 94.97 11.74 69 179618 112531 79452170
Fibromyalgia 93.76 11.74 16 179671 64324 79500377
Sudden death 93.73 11.74 176 179511 22335 79542366
Lower respiratory tract infection 93.29 11.74 92 179595 129128 79435573
White blood cell count increased 93.22 11.74 374 179313 74259 79490442
Abdominal pain upper 93.17 11.74 231 179456 223588 79341113
Psoriasis 92.44 11.74 43 179644 89544 79475157
Hypoaesthesia 90.59 11.74 166 179521 179186 79385515
Irritable bowel syndrome 89.56 11.74 16 179671 62225 79502476
Malignant neoplasm progression 89.08 11.74 105 179582 135885 79428816
Anticholinergic syndrome 88.80 11.74 70 179617 3541 79561160
Atrial fibrillation 87.33 11.74 198 179489 197688 79367013
Refusal of treatment by patient 86.40 11.74 104 179583 8887 79555814
Self-injurious ideation 86.20 11.74 69 179618 3569 79561132
Urinary retention 85.86 11.74 302 179385 56328 79508373
Weight decreased 85.37 11.74 461 179226 354737 79209964
Coma scale abnormal 84.41 11.74 101 179586 8577 79556124
Poisoning 84.14 11.74 180 179507 25092 79539609
COVID-19 84.11 11.74 141 179546 157533 79407168
C-reactive protein abnormal 82.80 11.74 7 179680 48360 79516341
Gastrointestinal disorder 82.60 11.74 92 179595 122113 79442588
Electroencephalogram abnormal 82.41 11.74 80 179607 5354 79559347
Withdrawal syndrome 82.30 11.74 185 179502 26669 79538032
Injection site pruritus 81.93 11.74 3 179684 42280 79522421
Mental status changes 81.60 11.74 333 179354 66626 79498075
Sleep disorder due to general medical condition, insomnia type 81.37 11.74 4 179683 43552 79521149
Contusion 81.26 11.74 131 179556 148645 79416056
Affective disorder 81.21 11.74 97 179590 8222 79556479
White blood cell count decreased 81.11 11.74 712 178975 187576 79377125
Knee arthroplasty 80.70 11.74 4 179683 43244 79521457
Gastrointestinal haemorrhage 79.81 11.74 131 179556 147588 79417113
Agranulocytosis 79.69 11.74 253 179434 44777 79519924
Depression 78.99 11.74 791 178896 215999 79348702
Urinary tract infection 78.34 11.74 335 179352 274177 79290524
Mydriasis 77.29 11.74 141 179546 17502 79547199
Logorrhoea 77.22 11.74 70 179617 4295 79560406
Myalgia 76.93 11.74 192 179495 185449 79379252
Disease progression 76.93 11.74 190 179497 184172 79380529
Blood pressure increased 76.13 11.74 234 179453 211126 79353575
Malaise 75.73 11.74 722 178965 489147 79075554
Neuropathy peripheral 75.70 11.74 126 179561 141179 79423522
Pericarditis 75.48 11.74 74 179613 104162 79460539
Muscle spasms 75.34 11.74 177 179510 174553 79390148
Abdominal pain 75.28 11.74 541 179146 389028 79175673
Stupor 75.24 11.74 85 179602 6787 79557914
Torsade de pointes 74.28 11.74 146 179541 19166 79545535
Behaviour disorder 74.13 11.74 81 179606 6232 79558469
Feeling guilty 73.74 11.74 37 179650 831 79563870
Refusal of examination 73.74 11.74 25 179662 193 79564508
Hyperammonaemia 73.61 11.74 107 179580 10986 79553715
Neutrophil count decreased 73.46 11.74 411 179276 93548 79471153
Pneumonia 73.09 11.74 1048 178639 659198 78905503
Type 1 diabetes mellitus 73.07 11.74 84 179603 6835 79557866
Injection site bruising 72.83 11.74 5 179682 40997 79523704
Amenorrhoea 72.33 11.74 88 179599 7604 79557097
Bronchitis 72.32 11.74 114 179573 130530 79434171
Hypertonia 71.71 11.74 85 179602 7147 79557554
Faecaloma 71.64 11.74 108 179579 11456 79553245
Wheezing 71.26 11.74 95 179592 116569 79448132
Hyperphagia 70.47 11.74 53 179634 2499 79562202
Bipolar I disorder 69.67 11.74 49 179638 2080 79562621
Depressive symptom 69.56 11.74 79 179608 6344 79558357
Intentional product misuse 68.99 11.74 408 179279 94757 79469944
Haematochezia 68.48 11.74 58 179629 87587 79477114
Grandiosity 68.11 11.74 31 179656 556 79564145
Basal cell carcinoma 68.05 11.74 4 179683 37371 79527330
Treatment failure 67.82 11.74 180 179507 170306 79394395
Delusional disorder, persecutory type 65.88 11.74 29 179658 479 79564222
Heat stroke 64.75 11.74 43 179644 1660 79563041
Acute psychosis 64.26 11.74 62 179625 4118 79560583
Cardiac arrest 64.16 11.74 631 179056 171465 79393236
Maternal exposure during pregnancy 64.05 11.74 132 179555 136406 79428295
Injection site swelling 63.86 11.74 14 179673 47118 79517583
Injection site reaction 63.53 11.74 22 179665 54763 79509938
Upper respiratory tract infection 63.41 11.74 67 179620 91101 79473600
Tension 63.37 11.74 63 179624 4341 79560360
Insurance issue 62.92 11.74 71 179616 5662 79559039
Water intoxication 62.85 11.74 32 179655 742 79563959
Autonomic nervous system imbalance 62.53 11.74 64 179623 4566 79560135
Insomnia 62.18 11.74 834 178853 244336 79320365
Inappropriate antidiuretic hormone secretion 62.18 11.74 164 179523 26149 79538552
Eosinophilic myocarditis 61.88 11.74 37 179650 1185 79563516
Antipsychotic drug level decreased 61.83 11.74 37 179650 1187 79563514
Pressure of speech 61.72 11.74 37 179650 1191 79563510
Somnambulism 61.34 11.74 70 179617 5651 79559050
Ileus paralytic 61.24 11.74 91 179596 9529 79555172
Brain injury 60.86 11.74 100 179587 11417 79553284
Paraesthesia 60.83 11.74 199 179488 176124 79388577
Impulse-control disorder 60.79 11.74 42 179645 1732 79562969
Polyuria 60.79 11.74 116 179571 14898 79549803
Acute kidney injury 60.78 11.74 815 178872 518589 79046112
Skin ulcer 60.66 11.74 23 179664 54127 79510574
Impulsive behaviour 60.33 11.74 51 179636 2849 79561852
Waxy flexibility 60.10 11.74 23 179664 260 79564441
Ill-defined disorder 60.07 11.74 37 179650 65838 79498863
Muscular weakness 59.99 11.74 175 179512 160554 79404147
Fluid retention 59.88 11.74 42 179645 69767 79494934
Withdrawal catatonia 59.62 11.74 21 179666 184 79564517
Diverticulitis 59.56 11.74 15 179672 45921 79518780
Asthenia 59.48 11.74 804 178883 510885 79053816
Suspiciousness 59.18 11.74 29 179658 618 79564083
Sciatica 59.16 11.74 4 179683 33218 79531483
Cytomegalovirus infection 59.14 11.74 12 179675 42632 79522069
Rash pruritic 58.96 11.74 45 179642 71584 79493117
Osteoporosis 58.95 11.74 24 179663 54088 79510613
Hyperreflexia 58.75 11.74 83 179604 8302 79556399
Food craving 58.60 11.74 40 179647 1617 79563084
Depressed mood 58.19 11.74 240 179447 48240 79516461
Productive cough 58.05 11.74 68 179619 88263 79476438
Paradoxical drug reaction 57.72 11.74 76 179611 7109 79557592
Type 2 diabetes mellitus 57.32 11.74 268 179419 56854 79507847
Hyperammonaemic encephalopathy 57.28 11.74 62 179625 4720 79559981
Abulia 57.22 11.74 33 179654 987 79563714
Overweight 57.21 11.74 58 179629 4092 79560609
Nasal congestion 56.99 11.74 53 179634 76499 79488202
Leukocytosis 56.86 11.74 221 179466 43234 79521467
Cataract 56.49 11.74 35 179652 62085 79502616
Dyspepsia 56.29 11.74 99 179588 108588 79456113
Major depression 55.81 11.74 84 179603 8896 79555805
Delusion of replacement 55.67 11.74 19 179668 150 79564551
Muscle injury 55.46 11.74 20 179667 48541 79516160
Feeling hot 55.24 11.74 33 179654 59701 79505000
Thrombosis 54.99 11.74 65 179622 84035 79480666
Hypertriglyceridaemia 54.78 11.74 101 179586 12639 79552062
Chills 54.47 11.74 182 179505 160052 79404649
Osteonecrosis of jaw 54.36 11.74 15 179672 43211 79521490
Ascites 54.29 11.74 54 179633 75508 79489193
Bursitis 54.29 11.74 8 179679 35836 79528865
Long QT syndrome 54.17 11.74 67 179620 5888 79558813
Hip arthroplasty 54.11 11.74 8 179679 35748 79528953
Staring 53.97 11.74 46 179641 2599 79562102
Rhinorrhoea 53.93 11.74 55 179632 76019 79488682
Joint range of motion decreased 53.85 11.74 6 179681 33276 79531425
Flushing 53.78 11.74 72 179615 88196 79476505
Oropharyngeal pain 53.62 11.74 103 179584 109250 79455451
Drug withdrawal syndrome 53.36 11.74 186 179501 34532 79530169
Flat affect 53.30 11.74 41 179646 2000 79562701
Trimethylaminuria 52.92 11.74 19 179668 177 79564524
Night sweats 52.22 11.74 26 179661 52069 79512632
Chest pain 52.11 11.74 397 179290 281907 79282794
Throat irritation 51.88 11.74 14 179673 40932 79523769
Asphyxia 51.76 11.74 94 179593 11626 79553075
Pleural effusion 51.45 11.74 162 179525 145100 79419601
Nephrolithiasis 51.34 11.74 28 179659 53263 79511438
Bezoar 51.31 11.74 45 179642 2643 79562058
Bone pain 51.25 11.74 31 179656 55711 79508990
Ataxia 51.17 11.74 148 179539 24891 79539810
Aspiration 51.09 11.74 129 179558 20029 79544672
Blunted affect 50.68 11.74 24 179663 473 79564228
Screaming 50.66 11.74 53 179634 3880 79560821
Hyperglycaemia 50.62 11.74 301 179386 70034 79494667
Decreased appetite 50.61 11.74 510 179177 341908 79222793
Pulmonary mass 50.25 11.74 4 179683 29030 79535671
Skin exfoliation 50.17 11.74 31 179656 55069 79509632
Fungal infection 49.74 11.74 16 179671 41732 79522969
Haematuria 49.68 11.74 49 179638 68787 79495914
Gynaecomastia 49.39 11.74 73 179614 7608 79557093
Hypokinesia 49.39 11.74 123 179564 18937 79545764
Pulmonary fibrosis 48.98 11.74 19 179668 44093 79520608
Drug level increased 48.94 11.74 198 179489 39453 79525248
Stereotypy 48.86 11.74 29 179658 916 79563785
Enuresis 48.62 11.74 47 179640 3129 79561572
Arrhythmia 48.53 11.74 269 179418 61003 79503698
Multiple sclerosis relapse 48.52 11.74 22 179665 46511 79518190
Delusional disorder, unspecified type 48.46 11.74 27 179660 755 79563946
Hallucination, olfactory 48.03 11.74 23 179664 465 79564236
Chronic kidney disease 47.84 11.74 47 179640 66107 79498594
Migraine 47.80 11.74 77 179610 87416 79477285
Illusion 47.73 11.74 36 179651 1705 79562996
Somatic symptom disorder of pregnancy 47.62 11.74 15 179672 89 79564612
Pancreatitis necrotising 47.39 11.74 51 179636 3857 79560844
Echolalia 46.95 11.74 21 179666 361 79564340
Electrocardiogram abnormal 46.56 11.74 111 179576 16626 79548075
Renal failure 46.49 11.74 264 179423 200704 79363997
Intestinal pseudo-obstruction 46.47 11.74 42 179645 2567 79562134
Device expulsion 46.38 11.74 3 179684 25858 79538843
Eosinophil count increased 46.03 11.74 112 179575 16993 79547708
Visceral congestion 45.97 11.74 28 179659 928 79563773
Renal impairment 45.93 11.74 191 179496 157592 79407109
Drug ineffective 45.92 11.74 2920 176767 1077993 78486708
Cor pulmonale acute 45.79 11.74 25 179662 671 79564030
Myelosuppression 45.33 11.74 17 179670 40279 79524422
Hyperkalaemia 45.31 11.74 121 179566 114277 79450424
Anxiolytic therapy 45.27 11.74 13 179674 53 79564648
Drug therapy enhancement 45.27 11.74 13 179674 53 79564648
Encephalitis autoimmune 44.99 11.74 39 179648 2255 79562446
Death 44.98 11.74 954 178733 565560 78999141
Inappropriate affect 44.88 11.74 33 179654 1503 79563198
Prostate cancer 44.83 11.74 10 179677 33258 79531443
Condition aggravated 44.63 11.74 1460 178227 499664 79065037
Angina pectoris 44.53 11.74 31 179656 51701 79513000
Injury 44.44 11.74 66 179621 77430 79487271
Illness 43.99 11.74 25 179662 46486 79518215
Hyperhidrosis 43.75 11.74 528 179159 150964 79413737
Torticollis 43.65 11.74 39 179648 2348 79562353
Neoplasm progression 43.14 11.74 32 179655 51650 79513051
Neuralgia 43.09 11.74 11 179676 33373 79531328
Spasmodic dysphonia 43.07 11.74 18 179669 260 79564441
Malignant catatonia 43.00 11.74 21 179666 444 79564257
Total lung capacity increased 42.92 11.74 38 179649 2260 79562441
Sepsis 42.88 11.74 394 179293 269034 79295667
Eosinophilia 42.78 11.74 209 179478 45136 79519565
Diabetic hyperosmolar coma 42.63 11.74 25 179662 772 79563929
International normalised ratio increased 42.23 11.74 79 179608 84642 79480059
Negative symptoms in schizophrenia 42.04 11.74 15 179672 137 79564564
Personality change due to a general medical condition 42.02 11.74 17 179670 225 79564476
Lethargy 41.75 11.74 320 179367 80972 79483729
Gout 41.24 11.74 4 179683 24745 79539956
Epilepsy 41.21 11.74 192 179495 40668 79524033
Device issue 41.17 11.74 6 179681 27102 79537599
Oromandibular dystonia 40.92 11.74 27 179660 1031 79563670
Brain stem thrombosis 40.78 11.74 8 179679 0 79564701
Breast engorgement 40.66 11.74 12 179675 55 79564646
Gamma-glutamyltransferase increased 40.63 11.74 236 179451 54444 79510257
Myoclonus 40.63 11.74 146 179541 27514 79537187
Reduced facial expression 40.61 11.74 40 179647 2725 79561976
Neck pain 40.61 11.74 67 179620 75350 79489351
Diet refusal 40.58 11.74 25 179662 846 79563855
Homicide 40.45 11.74 28 179659 1158 79563543
Loss of personal independence in daily activities 40.25 11.74 109 179578 102471 79462230
Ejaculation disorder 40.07 11.74 21 179666 518 79564183
Head banging 40.00 11.74 21 179666 520 79564181
Cystitis 39.85 11.74 36 179651 52696 79512005
General physical health deterioration 39.80 11.74 412 179275 274826 79289875
Self esteem decreased 39.80 11.74 26 179661 976 79563725
Hypometabolism 39.61 11.74 14 179673 124 79564577
Dysphoria 39.47 11.74 51 179636 4683 79560018
Erectile dysfunction 39.44 11.74 96 179591 14568 79550133
Pain in jaw 39.27 11.74 28 179659 46123 79518578
Ventricular arrhythmia 39.17 11.74 71 179616 8769 79555932
Anaphylactic shock 39.15 11.74 16 179671 35980 79528721
Melaena 38.81 11.74 48 179639 60842 79503859
Dementia with Lewy bodies 38.70 11.74 24 179663 822 79563879
High density lipoprotein decreased 38.58 11.74 50 179637 4605 79560096
Joint stiffness 38.54 11.74 22 179665 40808 79523893
Psychomotor skills impaired 38.42 11.74 53 179634 5184 79559517
Affect lability 38.41 11.74 81 179606 11178 79553523
Gastrointestinal sounds abnormal 38.37 11.74 54 179633 5381 79559320
Myocardial reperfusion injury 38.27 11.74 13 179674 101 79564600
Cardiomyopathy 38.19 11.74 147 179540 28627 79536074
Stress 38.15 11.74 76 179611 79536 79485165
Delusion of reference 38.11 11.74 14 179673 140 79564561
Tachyphrenia 38.06 11.74 34 179653 2046 79562655
Ear infection 37.95 11.74 15 179672 34417 79530284
Gaze palsy 37.82 11.74 40 179647 2965 79561736
Procedural pain 37.76 11.74 4 179683 23080 79541621
Retrograde ejaculation 37.70 11.74 17 179670 298 79564403
Embolism venous 37.45 11.74 47 179640 4192 79560509
Compulsive sexual behaviour 37.39 11.74 16 179671 246 79564455
Hanging 37.34 11.74 14 179673 149 79564552
Foot deformity 37.33 11.74 5 179682 24069 79540632
Phagophobia 37.17 11.74 11 179676 51 79564650
Sexually inappropriate behaviour 37.04 11.74 20 179667 525 79564176
Burning sensation 36.56 11.74 47 179640 58585 79506116
Alanine aminotransferase increased 36.35 11.74 541 179146 162029 79402672
Musculoskeletal stiffness 36.23 11.74 238 179449 174770 79389931
Dysphonia 36.07 11.74 45 179642 56827 79507874
Ketoacidosis 35.97 11.74 64 179623 7790 79556911
Aplastic anaemia 35.79 11.74 105 179582 17800 79546901
Incoherent 35.64 11.74 63 179624 7629 79557072
Blood pressure systolic increased 35.61 11.74 60 179627 66926 79497775
Alcohol use 35.60 11.74 49 179638 4782 79559919
Thought blocking 35.38 11.74 15 179672 225 79564476
Suicidal behaviour 35.27 11.74 40 179647 3207 79561494
Kidney infection 35.20 11.74 4 179683 21847 79542854
Rectal haemorrhage 34.73 11.74 75 179612 76225 79488476
Abnormal weight gain 34.72 11.74 36 179651 2608 79562093
Anger 34.65 11.74 101 179586 17061 79547640
Pneumocystis jirovecii pneumonia 34.47 11.74 15 179672 32493 79532208
Antisocial behaviour 34.37 11.74 21 179666 700 79564001
Resting tremor 34.24 11.74 28 179659 1493 79563208
Product substitution issue 34.19 11.74 112 179575 20144 79544557
Frequent bowel movements 34.01 11.74 12 179675 29527 79535174
Judgement impaired 33.70 11.74 26 179661 1274 79563427
Polydipsia psychogenic 33.64 11.74 14 179673 200 79564501
Limb discomfort 33.52 11.74 16 179671 32834 79531867
Metastases to liver 33.47 11.74 11 179676 28303 79536398
Dysgeusia 33.46 11.74 48 179639 57129 79507572
Apallic syndrome 33.36 11.74 23 179664 945 79563756
Plasma cell mastitis 33.22 11.74 9 179678 28 79564673
Symptom recurrence 33.11 11.74 33 179654 2281 79562420
Hypernatraemia 33.06 11.74 89 179598 14362 79550339
Localised infection 33.03 11.74 22 179665 37553 79527148
Troponin increased 32.98 11.74 107 179580 19148 79545553
Accidental overdose 32.84 11.74 176 179511 39405 79525296
Grip strength decreased 32.84 11.74 5 179682 21864 79542837
Hepatocellular injury 32.54 11.74 201 179486 47392 79517309
Encephalitis toxic 32.51 11.74 15 179672 278 79564423
Aspartate aminotransferase increased 32.42 11.74 465 179222 138176 79426525
Obsessive-compulsive personality disorder 32.41 11.74 12 179675 123 79564578
Somatic symptom disorder 32.34 11.74 34 179653 2503 79562198
Blood pressure diastolic abnormal 32.27 11.74 3 179684 19199 79545502
Unevaluable event 32.20 11.74 47 179640 55538 79509163
Hot flush 32.18 11.74 46 179641 54831 79509870
Asthma-chronic obstructive pulmonary disease overlap syndrome 32.17 11.74 38 179649 3183 79561518
Myocardial hypoxia 32.03 11.74 8 179679 16 79564685
Osteonecrosis 31.95 11.74 15 179672 31080 79533621
Surgery 31.88 11.74 17 179670 32749 79531952
Dissociative disorder 31.87 11.74 21 179666 800 79563901
Epistaxis 31.82 11.74 136 179551 111379 79453322
Iatrogenic injury 31.82 11.74 27 179660 1516 79563185
Cellulitis 31.74 11.74 132 179555 108928 79455773
Clonus 31.67 11.74 56 179631 6784 79557917
Gastric disorder 31.47 11.74 23 179664 37410 79527291
Candida infection 31.46 11.74 24 179663 38190 79526511
Hyperglycaemic hyperosmolar nonketotic syndrome 31.40 11.74 32 179655 2271 79562430
Eye movement disorder 31.33 11.74 61 179626 7950 79556751
Urinary incontinence 31.33 11.74 178 179509 40731 79523970
Haemorrhage 31.29 11.74 103 179584 91015 79473686
Dysphagia 31.14 11.74 416 179271 121720 79442981
Skin discolouration 31.03 11.74 28 179659 41006 79523695
Glassy eyes 31.02 11.74 12 179675 140 79564561
Drug monitoring procedure incorrectly performed 30.82 11.74 17 179670 466 79564235
Physical assault 30.81 11.74 27 179660 1584 79563117
Oral discharge 30.61 11.74 14 179673 254 79564447
Blood pressure fluctuation 30.56 11.74 66 179621 67079 79497622
Myelodysplastic syndrome 30.55 11.74 15 179672 30286 79534415
Bladder cancer 30.41 11.74 4 179683 19522 79545179
Soliloquy 30.37 11.74 19 179668 661 79564040
Derealisation 30.27 11.74 27 179660 1622 79563079
Cerebrovascular stenosis 30.14 11.74 12 179675 152 79564549
Cyclothymic disorder 30.08 11.74 13 179674 205 79564496
Breast discomfort 30.05 11.74 16 179671 408 79564293
Ulcer 29.97 11.74 15 179672 29957 79534744
Consciousness fluctuating 29.88 11.74 29 179658 1940 79562761
Hypersomnia 29.87 11.74 117 179570 22969 79541732
Lung disorder 29.83 11.74 88 179599 80469 79484232
Bone marrow failure 29.81 11.74 43 179644 51064 79513637
Joint effusion 29.78 11.74 3 179684 18011 79546690
Aspergillus infection 29.66 11.74 4 179683 19157 79545544
Injection site rash 29.66 11.74 3 179684 17951 79546750
Troponin T increased 29.45 11.74 38 179649 3484 79561217
Choreoathetosis 29.40 11.74 26 179661 1544 79563157
Myocardial infarction 29.39 11.74 269 179418 183860 79380841
Oral candidiasis 29.37 11.74 15 179672 29613 79535088
Ear pain 29.22 11.74 19 179668 32850 79531851
Helplessness 29.11 11.74 15 179672 357 79564344
Plasma cell myeloma 28.96 11.74 47 179640 53212 79511489
Angioedema 28.93 11.74 82 179605 75953 79488748
Impaired self-care 28.82 11.74 33 179654 2674 79562027
Ketosis-prone diabetes mellitus 28.81 11.74 8 179679 28 79564673
Distractibility 28.78 11.74 19 179668 726 79563975
Pulmonary arterial hypertension 28.66 11.74 14 179673 28352 79536349
Tendonitis 28.63 11.74 9 179678 23821 79540880
Restless legs syndrome 28.61 11.74 105 179582 19987 79544714
Flight of ideas 28.58 11.74 20 179667 842 79563859
Haemophagocytic lymphohistiocytosis 28.56 11.74 7 179680 21830 79542871
Body mass index increased 28.46 11.74 28 179659 1905 79562796
Immunodeficiency 28.43 11.74 7 179680 21761 79542940
Progressive multifocal leukoencephalopathy 28.15 11.74 6 179681 20594 79544107
Sluggishness 28.13 11.74 52 179635 6520 79558181
Disorganised speech 28.11 11.74 29 179658 2088 79562613
Coma scale 28.08 11.74 9 179678 57 79564644
Personality disorder 28.04 11.74 50 179637 6096 79558605
Metastases to bone 27.99 11.74 10 179677 24417 79540284
Somatic hallucination 27.94 11.74 9 179678 58 79564643
Hypervolaemia 27.90 11.74 33 179654 42657 79522044
Paraesthesia oral 27.89 11.74 6 179681 20465 79544236
Osteomyelitis 27.88 11.74 20 179667 32845 79531856
Cerebrovascular accident 27.87 11.74 220 179467 155072 79409629
Hypomagnesaemia 27.83 11.74 39 179648 46872 79517829
Bundle branch block right 27.48 11.74 71 179616 11180 79553521
Hepatic steatosis 27.47 11.74 162 179525 37576 79527125
Heart rate decreased 27.37 11.74 75 179612 70241 79494460
Bone disorder 27.31 11.74 5 179682 19108 79545593
Blepharospasm 27.21 11.74 48 179639 5803 79558898
Coronary artery disease 26.88 11.74 68 179619 65406 79499295
Morose 26.87 11.74 8 179679 38 79564663
Haemoglobin urine 26.76 11.74 11 179676 152 79564549
Oropharyngeal spasm 26.74 11.74 15 179672 425 79564276
Discoloured vomit 26.73 11.74 24 179663 1454 79563247
Compartment syndrome 26.68 11.74 44 179643 5038 79559663
Cardiac failure 26.58 11.74 222 179465 154620 79410081
Akinesia 26.55 11.74 35 179652 3277 79561424
Drug abuser 26.27 11.74 48 179639 5965 79558736
Alcohol abuse 26.25 11.74 45 179642 5318 79559383
Electrocardiogram T wave inversion 26.20 11.74 45 179642 5327 79559374
Neoplasm malignant 26.16 11.74 20 179667 31790 79532911
Oedema 26.09 11.74 160 179527 119420 79445281
Exhibitionism 26.06 11.74 8 179679 43 79564658
Device dislocation 25.97 11.74 13 179674 25957 79538744
Sedation complication 25.88 11.74 86 179601 15583 79549118
Skin reaction 25.74 11.74 3 179684 16065 79548636
Brain oedema 25.69 11.74 119 179568 25144 79539557
Clostridium difficile colitis 25.66 11.74 21 179666 32262 79532439
Pulmonary hypertension 25.62 11.74 43 179644 48037 79516664
Asocial behaviour 25.54 11.74 9 179678 79 79564622
Peptostreptococcus infection 25.44 11.74 9 179678 80 79564621
Perseveration 25.40 11.74 14 179673 383 79564318
Joint injury 25.39 11.74 20 179667 31315 79533386
Dry skin 25.38 11.74 74 179613 67921 79496780
Thrombotic microangiopathy 25.36 11.74 7 179680 20162 79544539
Glutamate dehydrogenase increased 25.32 11.74 7 179680 24 79564677
Rash erythematous 25.30 11.74 58 179629 57711 79506990
Breast enlargement 25.24 11.74 24 179663 1565 79563136
Multiple organ dysfunction syndrome 25.15 11.74 163 179524 120083 79444618
Compulsions 25.04 11.74 14 179673 394 79564307
Limb injury 25.01 11.74 18 179669 29510 79535191
Exostosis 24.99 11.74 4 179683 16854 79547847
Respiratory tract congestion 24.95 11.74 7 179680 19947 79544754
Tenderness 24.92 11.74 11 179676 23631 79541070
Full blood count abnormal 24.66 11.74 33 179654 40441 79524260
Acute myeloid leukaemia 24.66 11.74 20 179667 30865 79533836
Full blood count decreased 24.54 11.74 15 179672 26804 79537897
Septic shock 24.41 11.74 169 179518 122632 79442069
Faeces discoloured 24.35 11.74 18 179669 29109 79535592
Agitated depression 24.33 11.74 14 179673 417 79564284
Total cholesterol/HDL ratio increased 24.27 11.74 12 179675 261 79564440
Xanthoma 24.23 11.74 11 179676 196 79564505
Bronchopulmonary aspergillosis 24.10 11.74 10 179677 22284 79542417
Seasonal allergy 24.08 11.74 4 179683 16402 79548299
Patient restraint 23.98 11.74 9 179678 96 79564605
Therapeutic product effect variable 23.98 11.74 26 179661 1983 79562718
Tongue movement disturbance 23.94 11.74 14 179673 430 79564271
Oedema peripheral 23.91 11.74 412 179275 251876 79312825
Negative thoughts 23.90 11.74 22 179665 1377 79563324
Drug resistance 23.85 11.74 170 179517 42043 79522658
Palpitations 23.83 11.74 177 179510 126433 79438268
Osteopenia 23.80 11.74 6 179681 18358 79546343
Psychotic behaviour 23.79 11.74 20 179667 1109 79563592
Neuropsychiatric symptoms 23.68 11.74 22 179665 1393 79563308
Skin lesion 23.63 11.74 36 179651 41808 79522893
Psychotic disorder due to a general medical condition 23.54 11.74 12 179675 279 79564422
Metastases to lung 23.41 11.74 6 179681 18157 79546544
Adrenal insufficiency 23.31 11.74 18 179669 28469 79536232
Delusional disorder, erotomanic type 23.22 11.74 7 179680 35 79564666
Right ventricular failure 23.14 11.74 12 179675 23485 79541216
Haemorrhoids 23.09 11.74 19 179668 29109 79535592
Peripheral venous disease 23.08 11.74 4 179683 15905 79548796
Wrong patient received product 22.94 11.74 39 179648 4579 79560122
Uveitis 22.80 11.74 5 179682 16825 79547876
Cold-stimulus headache 22.74 11.74 7 179680 38 79564663
Hostility 22.65 11.74 27 179660 2283 79562418
Lower limb fracture 22.65 11.74 12 179675 23203 79541498
Gastrointestinal hypomotility 22.62 11.74 25 179662 1948 79562753
Oral pain 22.52 11.74 23 179664 31775 79532926
Squamous cell carcinoma 22.50 11.74 4 179683 15618 79549083
Neurodegenerative disorder 22.48 11.74 14 179673 483 79564218
Dizziness 22.39 11.74 964 178723 525477 79039224
Blood pressure diastolic decreased 22.39 11.74 21 179666 30195 79534506
Haemoptysis 22.34 11.74 59 179628 55940 79508761
Palmar-plantar erythrodysaesthesia syndrome 22.32 11.74 25 179662 33109 79531592
Drug screen positive 22.31 11.74 45 179642 6018 79558683
Hypersexuality 22.29 11.74 23 179664 1657 79563044
Hepatitis C virus test positive 22.09 11.74 13 179674 404 79564297
Antiphospholipid antibodies 22.05 11.74 9 179678 122 79564579
Upper gastrointestinal haemorrhage 22.05 11.74 37 179650 41343 79523358
Device related infection 21.89 11.74 27 179660 34267 79530434
Rash papular 21.87 11.74 11 179676 21905 79542796
Cerebral atrophy 21.86 11.74 53 179634 8022 79556679
Infusion site pain 21.85 11.74 3 179684 14173 79550528
Myoglobin blood increased 21.79 11.74 31 179656 3120 79561581
Abnormal clotting factor 21.79 11.74 10 179677 183 79564518
Disease recurrence 21.74 11.74 172 179515 43937 79520764
Hyperlipidaemia 21.63 11.74 116 179571 25977 79538724
Tic 21.58 11.74 30 179657 2956 79561745
Viral infection 21.53 11.74 40 179647 42976 79521725
Rash macular 21.51 11.74 20 179667 28879 79535822
Postural tremor 21.43 11.74 16 179671 746 79563955
Skin necrosis 21.43 11.74 7 179680 18080 79546621
Monocyte count decreased 21.42 11.74 31 179656 3170 79561531
Skin cancer 21.35 11.74 4 179683 15036 79549665
Secretion discharge 21.31 11.74 4 179683 15018 79549683
Drug level above therapeutic 21.25 11.74 55 179632 8668 79556033
Echopraxia 21.24 11.74 7 179680 49 79564652
Blood ketone body 21.23 11.74 9 179678 135 79564566
Flatulence 21.15 11.74 40 179647 42684 79522017
Slow speech 21.14 11.74 27 179660 2451 79562250
Musculoskeletal disorder 21.05 11.74 11 179676 21437 79543264
Homicidal ideation 21.01 11.74 32 179655 3425 79561276
Sneezing 21.00 11.74 9 179678 19674 79545027
Panic attack 21.00 11.74 109 179578 24107 79540594
Food refusal 20.95 11.74 14 179673 546 79564155
Haematoma 20.82 11.74 55 179632 52140 79512561
Pulmonary congestion 20.81 11.74 118 179569 26982 79537719
Electrocardiogram J wave abnormal 20.73 11.74 5 179682 8 79564693
Lymphocyte count abnormal 20.71 11.74 21 179666 1482 79563219
Delusional perception 20.54 11.74 12 179675 368 79564333
Drug use disorder 20.52 11.74 54 179633 8597 79556104
Fear 20.49 11.74 101 179586 21885 79542816
Gambling disorder 20.40 11.74 24 179663 2002 79562699
Deafness 20.34 11.74 11 179676 21026 79543675
Pancreatitis haemorrhagic 20.22 11.74 16 179671 814 79563887
Poverty of thought content 20.11 11.74 7 179680 59 79564642
Substance-induced psychotic disorder 20.07 11.74 31 179656 3358 79561343
Wrong technique in product usage process 19.92 11.74 92 179595 73783 79490918
Differential white blood cell count abnormal 19.92 11.74 24 179663 2053 79562648
Central nervous system lupus 19.85 11.74 13 179674 490 79564211
Wound infection 19.83 11.74 15 179672 23976 79540725
Cholelithiasis 19.55 11.74 193 179494 52471 79512230
Apraxia 19.53 11.74 28 179659 2839 79561862
Nodule 19.50 11.74 14 179673 22980 79541721
Skin disorder 19.37 11.74 29 179658 33914 79530787
Live birth 19.32 11.74 9 179678 18735 79545966
Femur fracture 19.30 11.74 36 179651 38616 79526085
Pulmonary toxicity 19.29 11.74 3 179684 12911 79551790
Abdominal pain lower 19.28 11.74 26 179661 31756 79532945
Colitis ischaemic 19.19 11.74 77 179610 15282 79549419
Thirst 19.15 11.74 88 179599 18531 79546170
Muscle twitching 19.13 11.74 108 179579 24656 79540045
Rebound effect 19.11 11.74 47 179640 7179 79557522
Eosinophilic pleural effusion 19.10 11.74 11 179676 328 79564373
Lupus-like syndrome 19.01 11.74 4 179683 13853 79550848
Hypotonia 18.96 11.74 68 179619 12802 79551899
Illness anxiety disorder 18.92 11.74 10 179677 251 79564450
Progressive supranuclear palsy 18.87 11.74 8 179679 120 79564581
Respiratory disorder 18.87 11.74 46 179641 44810 79519891
Throat tightness 18.86 11.74 21 179666 27886 79536815
Drop attacks 18.82 11.74 17 179670 1038 79563663
Obstructive airways disorder 18.81 11.74 26 179661 31433 79533268
Blood glucose 18.72 11.74 6 179681 38 79564663
Selective mutism 18.71 11.74 7 179680 74 79564627
Product communication issue 18.63 11.74 17 179670 1052 79563649
Circulatory collapse 18.63 11.74 147 179540 37521 79527180
Eating disorder 18.53 11.74 94 179593 20603 79544098
Appendicitis 18.51 11.74 12 179675 20782 79543919
Hunger 18.46 11.74 39 179648 5389 79559312
Hyperosmolar state 18.45 11.74 14 179673 669 79564032
Troponin I increased 18.44 11.74 36 179651 4702 79559999
Swelling face 18.43 11.74 90 179597 71122 79493579
Proteinuria 18.32 11.74 28 179659 32474 79532227
Communication disorder 18.31 11.74 33 179654 4057 79560644
Creatinine renal clearance decreased 18.28 11.74 10 179677 18992 79545709
Parkinsonian rest tremor 18.23 11.74 10 179677 271 79564430
Hyperbilirubinaemia 18.21 11.74 17 179670 24501 79540200
Inferiority complex 18.16 11.74 4 179683 3 79564698
Hyperchylomicronaemia 18.16 11.74 4 179683 3 79564698
Blood thrombin increased 18.16 11.74 4 179683 3 79564698
Labelled drug-drug interaction issue 18.13 11.74 19 179668 1394 79563307
Pneumonitis 18.12 11.74 73 179614 60787 79503914
COVID-19 pneumonia 18.11 11.74 23 179664 28826 79535875
Mouth ulceration 18.09 11.74 37 179650 38357 79526344
Tobacco interaction 17.99 11.74 7 179680 83 79564618
Tooth infection 17.98 11.74 10 179677 18822 79545879
Drug dependence 17.96 11.74 155 179532 40614 79524087
Postictal paralysis 17.94 11.74 11 179676 369 79564332
Bladder dilatation 17.94 11.74 23 179664 2096 79562605
Tongue biting 17.92 11.74 23 179664 2098 79562603
Foot fracture 17.84 11.74 14 179673 21967 79542734
Pharyngeal dystonia 17.73 11.74 6 179681 46 79564655
Injection site haemorrhage 17.73 11.74 22 179665 27848 79536853
Inappropriate schedule of product administration 17.71 11.74 204 179483 133424 79431277
Spinal compression fracture 17.70 11.74 8 179679 16950 79547751
Mucosal dryness 17.60 11.74 30 179657 3529 79561172
Therapeutic response changed 17.60 11.74 18 179669 1283 79563418
Self-medication 17.60 11.74 37 179650 5095 79559606
Lactic acidosis 17.60 11.74 90 179597 70269 79494432
Rotator cuff syndrome 17.52 11.74 5 179682 14090 79550611
Tooth disorder 17.44 11.74 20 179667 26213 79538488
Pseudomonas infection 17.37 11.74 13 179674 20890 79543811
Movement disorder 17.32 11.74 113 179574 27146 79537555
Abdominal distension 17.32 11.74 179 179508 119471 79445230
Breast cancer 17.28 11.74 31 179656 33750 79530951
Eosinophil count abnormal 17.28 11.74 14 179673 737 79563964
Meige's syndrome 17.16 11.74 4 179683 5 79564696
Red blood cell sedimentation rate increased 17.14 11.74 50 179637 45892 79518809
Neglect of personal appearance 17.11 11.74 8 179679 153 79564548
Eczema 17.06 11.74 42 179645 40776 79523925
Lymphadenopathy 17.06 11.74 62 179625 53185 79511516
Dry eye 17.06 11.74 36 179651 36895 79527806
Tubulointerstitial nephritis 17.06 11.74 38 179649 38197 79526504
Chorea 17.04 11.74 24 179663 2393 79562308
Electrocardiogram QT interval abnormal 17.02 11.74 10 179677 310 79564391
Abscess 16.95 11.74 16 179671 22935 79541766
Incontinence 16.90 11.74 70 179617 14094 79550607
Bacteraemia 16.90 11.74 30 179657 32794 79531907
Respiratory dyskinesia 16.89 11.74 6 179681 54 79564647
Mean cell haemoglobin concentration decreased 16.86 11.74 34 179653 4545 79560156
Therapy interrupted 16.72 11.74 28 179659 31313 79533388
Ideas of reference 16.70 11.74 8 179679 162 79564539
Libido decreased 16.69 11.74 37 179650 5284 79559417
Enthesopathy 16.66 11.74 3 179684 11605 79553096
Blood urea decreased 16.65 11.74 27 179660 3048 79561653
Bacterial infection 16.64 11.74 28 179659 31252 79533449
Alcoholism 16.62 11.74 30 179657 3693 79561008
Symptom masked 16.61 11.74 18 179669 1372 79563329
Premature delivery 16.59 11.74 17 179670 23450 79541251
Substance use 16.56 11.74 15 179672 919 79563782
Saccadic eye movement 16.52 11.74 8 179679 166 79564535
Dissociative identity disorder 16.42 11.74 6 179681 59 79564642
Muscle contractions involuntary 16.38 11.74 30 179657 3735 79560966
Tubo-ovarian abscess 16.38 11.74 10 179677 333 79564368
Hernia 16.38 11.74 9 179678 17050 79547651
Protrusion tongue 16.31 11.74 11 179676 436 79564265
Blood cholesterol abnormal 16.25 11.74 28 179659 3322 79561379
Paraphilia 16.25 11.74 6 179681 61 79564640
Postmortem blood drug level 16.24 11.74 10 179677 338 79564363
Eye pain 16.23 11.74 38 179649 37540 79527161
Pathogen resistance 16.22 11.74 6 179681 14336 79550365
Lacrimation increased 16.21 11.74 16 179671 22461 79542240
Injection site mass 16.20 11.74 13 179674 20171 79544530
Blood osmolarity increased 16.20 11.74 13 179674 675 79564026
Dissociation 16.19 11.74 31 179656 3990 79560711
Antidepressant drug level increased 16.19 11.74 11 179676 441 79564260
Motor dysfunction 16.18 11.74 71 179616 14662 79550039
Anterograde amnesia 16.15 11.74 13 179674 678 79564023
Aphthous ulcer 16.08 11.74 9 179678 16880 79547821
Staphylococcal infection 16.08 11.74 72 179615 58223 79506478
Opisthotonus 16.06 11.74 13 179674 683 79564018
Respiratory tract infection 16.06 11.74 56 179631 48633 79516068
Blood ethanol 16.05 11.74 8 179679 177 79564524
Macular degeneration 16.04 11.74 3 179684 11293 79553408
Benign ethnic neutropenia 15.99 11.74 6 179681 64 79564637
Angle closure glaucoma 15.94 11.74 26 179661 2950 79561751
Drowning 15.84 11.74 14 179673 831 79563870
Hyperarousal 15.83 11.74 5 179682 30 79564671
Tricuspid valve sclerosis 15.83 11.74 5 179682 30 79564671
Extensor plantar response 15.78 11.74 20 179667 1801 79562900
Blood sodium increased 15.77 11.74 34 179653 4764 79559937
Low density lipoprotein increased 15.76 11.74 49 179638 8573 79556128
Hypophagia 15.76 11.74 164 179523 45203 79519498
Prolactin-producing pituitary tumour 15.72 11.74 7 179680 119 79564582
Hepatotoxicity 15.70 11.74 181 179506 51171 79513530
Gastric ulcer 15.70 11.74 33 179654 33872 79530829
Ageusia 15.64 11.74 9 179678 16623 79548078
Intellectual disability 15.61 11.74 17 179670 1303 79563398
Skin fissures 15.59 11.74 5 179682 13068 79551633
Cerebellar atrophy 15.59 11.74 16 179671 1145 79563556
Vomiting 15.45 11.74 1291 178396 664537 78900164
Psychogenic visual disorder 15.42 11.74 5 179682 33 79564668
Postoperative wound infection 15.38 11.74 5 179682 12956 79551745
Starvation 15.37 11.74 11 179676 480 79564221
Hospitalisation 15.35 11.74 298 179389 93938 79470763
Organising pneumonia 15.33 11.74 3 179684 10936 79553765
Extrasystoles 15.30 11.74 44 179643 7375 79557326
Cyst 15.30 11.74 6 179681 13834 79550867
Neutrophilia 15.29 11.74 46 179641 7905 79556796
Inborn error of metabolism 15.29 11.74 3 179684 0 79564701
Pseudogynaecomastia 15.29 11.74 3 179684 0 79564701
Intravascular papillary endothelial hyperplasia 15.29 11.74 3 179684 0 79564701
Psychiatric evaluation abnormal 15.29 11.74 3 179684 0 79564701
Chylomicron increased 15.29 11.74 3 179684 0 79564701
Tachypnoea 15.24 11.74 124 179563 31939 79532762
Dyspraxia 15.20 11.74 9 179678 283 79564418
Food allergy 15.10 11.74 3 179684 10821 79553880
Illiteracy 15.05 11.74 5 179682 36 79564665
Sinus bradycardia 15.04 11.74 103 179584 25144 79539557
Pharyngeal oedema 15.03 11.74 9 179678 16263 79548438
Liver injury 14.97 11.74 71 179616 56543 79508158
Pancytopenia 14.95 11.74 273 179414 165472 79399229
Product storage error 14.95 11.74 9 179678 16217 79548484
Pupillary reflex impaired 14.94 11.74 27 179660 3326 79561375
Glycosylated haemoglobin increased 14.88 11.74 84 179603 19176 79545525
Mixed delusion 14.87 11.74 4 179683 12 79564689
Cerebellar syndrome 14.87 11.74 36 179651 5444 79559257
Off label use 14.86 11.74 1804 177883 905411 78659290
Pancreatitis 14.85 11.74 227 179460 68348 79496353
Nephrogenic diabetes insipidus 14.77 11.74 21 179666 2113 79562588
Laryngitis 14.63 11.74 9 179678 16030 79548671
Breath sounds abnormal 14.54 11.74 9 179678 15975 79548726
Hepatic cancer 14.52 11.74 3 179684 10526 79554175
Rhinalgia 14.51 11.74 22 179665 2345 79562356
Pica 14.49 11.74 5 179682 41 79564660
Pneumothorax 14.48 11.74 26 179661 28297 79536404
Parkinsonian gait 14.46 11.74 14 179673 934 79563767
Dermatitis 14.45 11.74 16 179671 21305 79543396
Bone density decreased 14.41 11.74 6 179681 13341 79551360
Increased tendency to bruise 14.39 11.74 3 179684 10461 79554240
Gastroenteritis viral 14.38 11.74 21 179666 24810 79539891
Coagulopathy 14.31 11.74 38 179649 35968 79528733
Autoimmune disorder 14.23 11.74 10 179677 16602 79548099
Feelings of worthlessness 14.22 11.74 11 179676 541 79564160
Secondary tic 14.19 11.74 4 179683 15 79564686
Slow response to stimuli 14.19 11.74 19 179668 1806 79562895
Poor venous access 14.18 11.74 12 179675 18137 79546564
Blood creatine phosphokinase decreased 14.15 11.74 14 179673 959 79563742
Thyroid disorder 14.15 11.74 7 179680 14072 79550629
Colitis 14.02 11.74 102 179585 73205 79491496
Haemoglobin decreased 14.01 11.74 387 179300 221732 79342969
Hepatic enzyme increased 14.00 11.74 309 179378 182301 79382400
Spinal disorder 13.99 11.74 3 179684 10257 79554444
Carpal tunnel syndrome 13.97 11.74 14 179673 19514 79545187
Mean cell haemoglobin decreased 13.90 11.74 38 179649 6186 79558515
Circadian rhythm sleep disorder 13.90 11.74 12 179675 690 79564011
Hypoxic-ischaemic encephalopathy 13.89 11.74 44 179643 7776 79556925
Schizophreniform disorder 13.88 11.74 7 179680 159 79564542
Acute myocardial infarction 13.88 11.74 109 179578 76927 79487774
Organic erectile dysfunction 13.80 11.74 6 179681 96 79564605
Constricted affect 13.80 11.74 4 179683 17 79564684
Walking aid user 13.77 11.74 3 179684 10145 79554556
Red blood cells urine 13.74 11.74 12 179675 701 79564000
Pyrexia 13.71 11.74 1330 178357 677379 78887322
Infusion site extravasation 13.70 11.74 3 179684 10105 79554596
Shock haemorrhagic 13.66 11.74 15 179672 20045 79544656
Excessive masturbation 13.64 11.74 6 179681 99 79564602
Blood chloride decreased 13.61 11.74 45 179642 8132 79556569
Product packaging confusion 13.59 11.74 8 179679 249 79564452
Menstruation irregular 13.58 11.74 33 179654 5003 79559698
Device malfunction 13.57 11.74 17 179670 21431 79543270
Immune system disorder 13.55 11.74 4 179683 11025 79553676
Spinal pain 13.54 11.74 9 179678 15383 79549318
Multiple drug therapy 13.52 11.74 29 179658 4049 79560652
Poverty of speech 13.51 11.74 11 179676 583 79564118
Joint dislocation 13.49 11.74 11 179676 16928 79547773
Regressive behaviour 13.46 11.74 7 179680 170 79564531
Affective ambivalence 13.44 11.74 4 179683 19 79564682
Floppy iris syndrome 13.40 11.74 9 179678 354 79564347
Disseminated intravascular coagulation 13.38 11.74 39 179648 35803 79528898
Heart rate irregular 13.37 11.74 34 179653 32645 79532056
Salivary gland calculus 13.36 11.74 8 179679 257 79564444
Musculoskeletal discomfort 13.32 11.74 15 179672 19820 79544881
Posturing 13.22 11.74 14 179673 1039 79563662
Hypogonadism 13.19 11.74 18 179669 1742 79562959
Coprolalia 13.19 11.74 5 179682 55 79564646
Frontotemporal dementia 13.17 11.74 11 179676 604 79564097
Ovarian cyst 13.17 11.74 6 179681 12649 79552052
Complication associated with device 13.15 11.74 12 179675 17484 79547217
Pituitary tumour benign 13.12 11.74 22 179665 2554 79562147
Blood bilirubin increased 13.11 11.74 216 179471 66016 79498685
Congestive cardiomyopathy 13.11 11.74 57 179630 11723 79552978
Alcohol problem 13.11 11.74 5 179682 56 79564645
Cytopenia 13.06 11.74 16 179671 20367 79544334
Colitis microscopic 13.05 11.74 4 179683 10764 79553937
Decreased gait velocity 13.02 11.74 7 179680 182 79564519
Sinus disorder 13.00 11.74 19 179668 22445 79542256
Confabulation 13.00 11.74 10 179677 488 79564213
Tangentiality 12.99 11.74 7 179680 183 79564518
Orthostatic hypotension 12.97 11.74 188 179499 55976 79508725
Toxic epidermal necrolysis 12.94 11.74 54 179633 44527 79520174
Electrocardiogram T wave abnormal 12.88 11.74 27 179660 3711 79560990
Electrocardiogram J wave 12.87 11.74 5 179682 59 79564642
Trismus 12.84 11.74 34 179653 5433 79559268
Angina unstable 12.83 11.74 11 179676 16516 79548185
Colitis ulcerative 12.82 11.74 38 179649 34704 79529997
Neutropenic sepsis 12.82 11.74 26 179661 27038 79537663
Neuroleptic-induced deficit syndrome 12.80 11.74 4 179683 23 79564678
Fluid intake restriction 12.73 11.74 5 179682 61 79564640
Intervertebral disc protrusion 12.70 11.74 21 179666 23600 79541101
Enterococcal infection 12.68 11.74 10 179677 15650 79549051
Pathological fracture 12.62 11.74 4 179683 10533 79554168
Chemical poisoning 12.59 11.74 7 179680 195 79564506
Duodenal ulcer 12.58 11.74 11 179676 16358 79548343
Pneumonia bacterial 12.57 11.74 15 179672 19316 79545385
Wrong drug 12.54 11.74 8 179679 288 79564413
White blood cells urine positive 12.50 11.74 36 179651 6039 79558662
Multiple allergies 12.48 11.74 4 179683 10456 79554245
Malignant melanoma 12.47 11.74 9 179678 14732 79549969
Psychosexual disorder 12.46 11.74 6 179681 123 79564578
Gastrointestinal necrosis 12.46 11.74 34 179653 5531 79559170
Thermal burn 12.45 11.74 40 179647 7120 79557581
Renal cyst 12.45 11.74 9 179678 14723 79549978
Infusion site erythema 12.43 11.74 3 179684 9457 79555244
Product measured potency issue 12.43 11.74 7 179680 200 79564501
Exposure during pregnancy 12.39 11.74 307 179380 100825 79463876
Ankylosing spondylitis 12.37 11.74 6 179681 12199 79552502
Flashback 12.35 11.74 8 179679 296 79564405
Rash pustular 12.34 11.74 5 179682 11306 79553395
Respiratory syncytial virus infection 12.32 11.74 3 179684 9399 79555302
Hypoventilation 12.24 11.74 40 179647 7184 79557517
Glucocorticoids increased 12.24 11.74 6 179681 128 79564573
Lip swelling 12.22 11.74 49 179638 40862 79523839
Dependent personality disorder 12.20 11.74 6 179681 129 79564572
Hypogammaglobulinaemia 12.19 11.74 7 179680 12944 79551757
Fistula 12.17 11.74 7 179680 12933 79551768
Intercepted product prescribing error 12.16 11.74 8 179679 304 79564397
Brief psychotic disorder, with postpartum onset 12.14 11.74 4 179683 28 79564673
Intestinal infarction 12.10 11.74 15 179672 1321 79563380
Visual impairment 12.07 11.74 141 179546 91990 79472711
Lymphocyte count increased 12.06 11.74 35 179652 5897 79558804
Paternal exposure timing unspecified 12.04 11.74 5 179682 71 79564630
Skin infection 12.03 11.74 14 179673 18231 79546470
Gun shot wound 12.01 11.74 14 179673 1156 79563545
Tremor neonatal 12.01 11.74 3 179684 6 79564695
Mass 11.97 11.74 13 179674 17459 79547242
Panic disorder 11.97 11.74 23 179664 2969 79561732
Peripheral coldness 11.95 11.74 11 179676 15959 79548742
Right ventricular dilatation 11.95 11.74 18 179669 1908 79562793
Immunosuppression 11.94 11.74 7 179680 12796 79551905
Drug level decreased 11.92 11.74 64 179623 14338 79550363
Labelled drug-drug interaction medication error 11.91 11.74 28 179659 27622 79537079
Mucosal inflammation 11.80 11.74 111 179576 75469 79489232
Breathing-related sleep disorder 11.77 11.74 7 179680 222 79564479

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure during pregnancy 31.88 24.96 40 523 1294 87935
Fever neonatal 26.71 24.96 8 555 9 89220

Pharmacologic Action:

SourceCodeDescription
ATC N05AH03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
ATC N05AH53 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D017367 Selective Serotonin Reuptake Inhibitors
MeSH PA D018490 Serotonin Agents
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:65191 atypical antipsychotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Major depressive disorder indication 370143000
Depression Treatment Adjunct indication
Agitation associated with Bipolar Mania indication
Agitation associated with Schizophrenia indication
Nausea and vomiting off-label use 16932000
Feeling agitated off-label use 24199005
Migraine off-label use 37796009 DOID:6364
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Chemotherapy-induced nausea and vomiting off-label use 236084000
cannabinoid hyperememsis off-label use 11047881000119100
cannabinoid hyperememsis off-label use 11048011000119100
Delirium contraindication 2776000
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Sedation contraindication 72641008
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.72 Basic
pKa3 0.66 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10300054 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 10716785 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11185541 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11241425 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 11351166 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9126977 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 9517235 Aug. 23, 2031 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL 8778960 Feb. 13, 2032 METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
15MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
20MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY
5MG;EQ 10MG BASE LYBALVI ALKERMES INC N213378 May 28, 2021 RX TABLET ORAL May 28, 2026 NEW CHEMICAL ENTITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.32 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.52 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 7.40 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.49 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.74 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 6.26 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Kd 5.90 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 7.92 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.98 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.72 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.09 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.10 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.16 WOMBAT-PK
Histamine H2 receptor GPCR Ki 7.36 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.51 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.10 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.14 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.68 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 8.05 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.22 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 6.12 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.54 WOMBAT-PK
D(4) dopamine receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 7.59 DRUG MATRIX
5-hydroxytryptamine receptor 3A Ion channel Ki 6.70 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.92 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.70 IUPHAR
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 6.43 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Histone H1.0 Nuclear other Ki 8.70 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Arachidonate 15-lipoxygenase Enzyme IC50 5.56 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.68 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.36 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 7.19 CHEMBL
Histamine H1 receptor GPCR Ki 8.20 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.66 CHEMBL
D(2) dopamine receptor GPCR Ki 7.90 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.40 CHEMBL
Transporter Transporter Ki 6.02 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 9.52 CHEMBL
D(3) dopamine receptor GPCR Ki 7.41 CHEMBL
D(4) dopamine receptor GPCR Ki 7.30 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.60 IUPHAR
Transporter Transporter Ki 5.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.54 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.92 CHEMBL

External reference:

IDSource
4020996 VUID
N0000148465 NUI
D00454 KEGG_DRUG
221373-18-8 SECONDARY_CAS_RN
4020996 VANDF
C0171023 UMLSCUI
CHEBI:7735 CHEBI
CHEMBL715 ChEMBL_ID
CHEMBL1201741 ChEMBL_ID
CHEMBL3989694 ChEMBL_ID
DB00334 DRUGBANK_ID
D000077152 MESH_DESCRIPTOR_UI
135398745 PUBCHEM_CID
47 IUPHAR_LIGAND_ID
6956 INN_ID
N7U69T4SZR UNII
1294588 RXNORM
169390 MMSL
172501 MMSL
39248 MMSL
5198 MMSL
6063 MMSL
d04050 MMSL
006204 NDDF
013309 NDDF
108441004 SNOMEDCT_US
386849001 SNOMEDCT_US
725800004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 3 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 3 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 6 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 6 mg ORAL NDA 34 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 36 sections