olanzapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1982 132539-06-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • olanzapine pamoate
  • olanzapine embonate
  • zyprexa relprevv
  • olanzapine pamoate monohydrate
  • olanzapine
  • zyprexa
  • LY 170053
  • LY-170053
The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown.
  • Molecular weight: 312.44
  • Formula: C17H20N4S
  • CLOGP: 2.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.52
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1996 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1206.55 10.75 517 80036 10605 46594904
Intentional overdose 832.72 10.75 772 79781 64172 46541337
Suicide attempt 821.77 10.75 713 79840 54323 46551186
Sedation 719.41 10.75 464 80089 22446 46583063
Psychotic disorder 665.90 10.75 440 80113 22181 46583328
Schizophrenia 642.59 10.75 308 80245 8260 46597249
Intentional self-injury 604.32 10.75 425 80128 23741 46581768
Extrapyramidal disorder 508.20 10.75 288 80265 10980 46594529
Akathisia 505.72 10.75 253 80300 7461 46598048
Electrocardiogram QT prolonged 488.44 10.75 519 80034 50806 46554703
Sopor 468.68 10.75 337 80216 19491 46586018
Agitation 464.17 10.75 524 80029 54891 46550618
Overdose 458.21 10.75 710 79843 101269 46504240
Toxicity to various agents 425.63 10.75 1049 79504 210717 46394792
Weight increased 415.66 10.75 892 79661 163581 46441928
Dystonia 398.31 10.75 246 80307 11011 46594498
Drug interaction 395.35 10.75 994 79559 202100 46403409
Delusion 371.92 10.75 235 80318 10953 46594556
Mania 366.02 10.75 230 80323 10616 46594893
Rheumatoid arthritis 364.57 10.75 11 80542 240204 46365305
Arthralgia 354.39 10.75 96 80457 364507 46241002
Catatonia 349.81 10.75 157 80396 3605 46601904
Drug abuse 347.49 10.75 485 80068 62923 46542586
Post-injection delirium sedation syndrome 345.10 10.75 67 80486 16 46605493
Parkinsonism 341.89 10.75 197 80356 7751 46597758
Blood prolactin abnormal 341.05 10.75 115 80438 1174 46604335
Hyperprolactinaemia 333.37 10.75 141 80412 2791 46602718
Diabetes mellitus 329.71 10.75 419 80134 49646 46555863
Somnolence 318.98 10.75 780 79773 155741 46449768
Hallucination, auditory 308.61 10.75 206 80347 10550 46594959
Sexual dysfunction 305.00 10.75 125 80428 2278 46603231
Anosognosia 304.53 10.75 108 80445 1297 46604212
Coma 276.93 10.75 417 80136 57932 46547577
Pain 270.02 10.75 256 80297 476692 46128817
Disturbance in social behaviour 268.27 10.75 104 80449 1627 46603882
Metabolic disorder 263.20 10.75 136 80417 4296 46601213
Tardive dyskinesia 262.16 10.75 163 80390 7380 46598129
Hypothermia 251.69 10.75 191 80362 11992 46593517
Completed suicide 239.61 10.75 671 79882 145249 46460260
Dyskinesia 237.73 10.75 271 80282 28654 46576855
Suicidal ideation 224.71 10.75 372 80181 56010 46549499
Headache 222.46 10.75 301 80252 478051 46127458
Aggression 216.18 10.75 230 80323 22514 46582995
Muscle rigidity 214.28 10.75 160 80393 9801 46595708
Salivary hypersecretion 210.75 10.75 134 80419 6311 46599198
Depressed level of consciousness 210.24 10.75 329 80224 47240 46558269
Diarrhoea 208.03 10.75 408 80145 559194 46046315
Psychomotor hyperactivity 203.65 10.75 153 80400 9460 46596049
Confusional state 200.46 10.75 669 79884 159223 46446286
Metabolic syndrome 198.47 10.75 77 80476 1207 46604302
Delirium 196.76 10.75 280 80273 36948 46568561
Pleurothotonus 194.88 10.75 74 80479 1091 46604418
Hypomania 194.69 10.75 111 80442 4277 46601232
Fatigue 190.20 10.75 488 80065 608209 45997300
Restlessness 189.50 10.75 227 80326 25297 46580212
Gestational diabetes 187.44 10.75 130 80423 7089 46598420
Blood prolactin increased 185.85 10.75 95 80458 2932 46602577
Dyspnoea 184.56 10.75 384 80169 515164 46090345
Prescribed overdose 171.26 10.75 143 80410 10306 46595203
Hallucination 169.48 10.75 307 80246 49644 46555865
Personality change 168.64 10.75 108 80445 5150 46600359
Drug hypersensitivity 165.09 10.75 109 80444 243716 46361793
Tachycardia 160.31 10.75 455 80098 99167 46506342
Persecutory delusion 159.23 10.75 81 80472 2474 46603035
Exposure during pregnancy 152.03 10.75 471 80082 107741 46497768
Miosis 150.07 10.75 110 80443 6547 46598962
Paranoia 147.30 10.75 132 80421 10465 46595044
Pain in extremity 146.94 10.75 138 80415 258542 46346967
Abnormal behaviour 146.10 10.75 181 80372 20877 46584632
Sinusitis 140.03 10.75 27 80526 129741 46475768
Oculogyric crisis 139.18 10.75 59 80494 1174 46604335
Back pain 135.37 10.75 99 80454 209940 46395569
Pruritus 133.31 10.75 133 80420 242219 46363290
Injection site pain 132.39 10.75 15 80538 107137 46498372
Rash 132.02 10.75 260 80293 356252 46249257
Type 2 diabetes mellitus 122.37 10.75 161 80392 19714 46585795
Social avoidant behaviour 121.10 10.75 70 80483 2769 46602740
Treatment noncompliance 120.85 10.75 198 80355 29533 46575976
Schizoaffective disorder 120.51 10.75 56 80497 1396 46604113
Joint swelling 119.60 10.75 69 80484 166004 46439505
Bipolar disorder 119.23 10.75 99 80454 7078 46598431
Abdominal discomfort 118.93 10.75 56 80497 151109 46454400
Nausea 116.87 10.75 703 79850 686751 45918758
Galactorrhoea 116.86 10.75 76 80477 3721 46601788
Dysarthria 114.10 10.75 220 80333 37278 46568231
Blood creatine phosphokinase increased 111.83 10.75 184 80369 27540 46577969
Peripheral swelling 109.16 10.75 69 80484 158002 46447507
Cough 108.56 10.75 143 80410 230106 46375403
Antipsychotic drug level increased 108.44 10.75 68 80485 3124 46602385
Hypersensitivity 107.46 10.75 63 80490 150258 46455251
Infusion related reaction 107.20 10.75 22 80531 101186 46504323
Arthropathy 106.80 10.75 11 80542 84689 46520820
Blood triglycerides increased 106.40 10.75 116 80437 11667 46593842
Tremor 106.27 10.75 438 80115 115201 46490308
Nasopharyngitis 101.25 10.75 71 80482 153927 46451582
Pneumonia aspiration 98.09 10.75 187 80366 31418 46574091
Psychiatric decompensation 95.35 10.75 44 80509 1079 46604430
Antipsychotic drug level above therapeutic 93.02 10.75 41 80512 900 46604609
Alopecia 92.88 10.75 86 80467 162328 46443181
Urticaria 92.21 10.75 44 80509 117848 46487661
Product dose omission issue 90.86 10.75 94 80459 168426 46437083
Injection site erythema 90.47 10.75 11 80542 74416 46531093
Diabetic coma 90.39 10.75 38 80515 740 46604769
Disorientation 90.36 10.75 198 80355 36720 46568789
Orthostatic hypertension 89.64 10.75 27 80526 184 46605325
Rhabdomyolysis 89.54 10.75 213 80340 41696 46563813
Chest discomfort 88.87 10.75 23 80530 90246 46515263
Swelling 86.43 10.75 54 80499 124457 46481052
Leukopenia 84.60 10.75 285 80268 68058 46537451
Obesity 84.25 10.75 113 80440 14093 46591416
Respiratory depression 84.16 10.75 102 80451 11498 46594011
Granulocytopenia 84.00 10.75 71 80482 5202 46600307
Contraindicated product administered 83.38 10.75 18 80535 79929 46525580
Psychiatric symptom 83.07 10.75 66 80487 4431 46601078
Bradyphrenia 81.47 10.75 75 80478 6155 46599354
Arthritis 81.46 10.75 17 80536 77299 46528210
Posture abnormal 80.35 10.75 49 80504 2141 46603368
Amenorrhoea 79.32 10.75 87 80466 8808 46596701
Drug intolerance 79.28 10.75 82 80471 146967 46458542
Anxiety 78.40 10.75 560 79993 181397 46424112
Neutropenia 77.68 10.75 467 80086 142737 46462772
Apathy 75.31 10.75 77 80476 7191 46598318
Obsessive-compulsive disorder 74.45 10.75 54 80499 3161 46602348
Blood glucose increased 74.36 10.75 283 80270 71730 46533779
Generalised tonic-clonic seizure 72.76 10.75 151 80402 26971 46578538
Mental disorder 72.45 10.75 135 80418 22290 46583219
Psoriasis 71.89 10.75 23 80530 78581 46526928
Polydipsia 71.25 10.75 53 80500 3226 46602283
Jaundice cholestatic 70.59 10.75 63 80490 4966 46600543
Increased appetite 70.21 10.75 80 80473 8447 46597062
Serotonin syndrome 67.51 10.75 137 80416 24083 46581426
Cogwheel rigidity 66.93 10.75 38 80515 1452 46604057
Myalgia 63.71 10.75 71 80482 123017 46482492
Negativism 62.34 10.75 24 80529 368 46605141
Pulmonary embolism 61.35 10.75 358 80195 108227 46497282
Influenza 60.18 10.75 40 80513 89230 46516279
Thinking abnormal 59.63 10.75 79 80474 9735 46595774
Drug level increased 59.55 10.75 111 80442 18330 46587179
Osteoarthritis 58.79 10.75 17 80536 62008 46543501
Treatment failure 58.44 10.75 45 80508 93042 46512467
Systemic lupus erythematosus 57.98 10.75 20 80533 65160 46540349
Malaise 57.39 10.75 336 80217 330896 46274613
Acute psychosis 56.76 10.75 38 80515 1954 46603555
Injection site pruritus 56.21 10.75 3 80550 39740 46565769
Mental impairment 56.17 10.75 87 80466 12369 46593140
Camptocormia 55.82 10.75 19 80534 200 46605309
Mutism 55.30 10.75 32 80521 1268 46604241
Anaphylactic reaction 55.28 10.75 12 80541 53100 46552409
Dyslipidaemia 54.35 10.75 57 80496 5483 46600026
Cardio-respiratory arrest 54.33 10.75 226 80327 59643 46545866
Seizure 54.27 10.75 381 80172 122673 46482836
Herpes zoster 53.56 10.75 25 80528 67847 46537662
Screaming 52.96 10.75 44 80509 3147 46602362
Myocarditis 52.83 10.75 66 80487 7673 46597836
Hyperglycaemia 52.30 10.75 156 80397 34915 46570594
Obsessive thoughts 52.05 10.75 23 80530 508 46605001
Hallucinations, mixed 51.62 10.75 47 80506 3802 46601707
Obsessive-compulsive symptom 51.56 10.75 12 80541 23 46605486
Psychotic symptom 51.38 10.75 27 80526 883 46604626
Poisoning 51.28 10.75 89 80464 13905 46591604
Speech disorder 51.24 10.75 158 80395 36009 46569500
Psychomotor retardation 50.41 10.75 43 80510 3190 46602319
Bone pain 50.03 10.75 10 80543 46880 46558629
Sinus tachycardia 49.48 10.75 113 80440 21536 46583973
Irritability 49.23 10.75 135 80418 28811 46576698
Chest pain 48.31 10.75 150 80403 176174 46429335
Hyponatraemia 47.79 10.75 319 80234 101013 46504496
Neuropathy peripheral 47.49 10.75 52 80501 90841 46514668
Asthma 47.14 10.75 53 80500 91489 46514020
Depression 46.42 10.75 473 80080 169631 46435878
Wheezing 46.42 10.75 17 80536 53369 46552140
Infection 46.27 10.75 101 80452 133491 46472018
Somatic symptom disorder of pregnancy 45.79 10.75 14 80539 101 46605408
Urinary retention 45.78 10.75 123 80430 25938 46579571
Injection site reaction 45.56 10.75 13 80540 47836 46557673
Hyperammonaemic encephalopathy 45.23 10.75 33 80520 1949 46603560
Abdominal pain 44.95 10.75 224 80329 229807 46375702
Hyperthermia 44.87 10.75 62 80491 7952 46597557
Hypoaesthesia 44.44 10.75 86 80467 118783 46486726
Trimethylaminuria 44.40 10.75 15 80538 154 46605355
Logorrhoea 44.38 10.75 35 80518 2324 46603185
Hyperphagia 44.20 10.75 30 80523 1578 46603931
Diet refusal 44.00 10.75 22 80531 647 46604862
Altered state of consciousness 43.87 10.75 113 80440 23235 46582274
Flushing 43.48 10.75 29 80524 64585 46540924
Stupor 43.38 10.75 41 80512 3479 46602030
Abdominal pain upper 43.14 10.75 119 80434 145186 46460323
Brain stem thrombosis 42.91 10.75 8 80545 0 46605509
Respiratory arrest 42.69 10.75 142 80411 33674 46571835
Glossodynia 42.35 10.75 12 80541 44361 46561148
Unresponsive to stimuli 42.31 10.75 137 80416 32037 46573472
Symptom recurrence 41.57 10.75 18 80535 378 46605131
Disturbance in attention 41.16 10.75 134 80419 31426 46574083
Mydriasis 41.15 10.75 69 80484 10484 46595025
Alanine aminotransferase increased 40.83 10.75 277 80276 88174 46517335
Nasal congestion 40.70 10.75 16 80537 48097 46557412
Bipolar I disorder 40.50 10.75 28 80525 1518 46603991
White blood cell count increased 40.17 10.75 167 80386 44052 46561457
Neck pain 39.73 10.75 23 80530 55283 46550226
Delusion of reference 39.69 10.75 12 80541 83 46605426
Osteonecrosis of jaw 39.63 10.75 6 80547 34396 46571113
Coma scale abnormal 39.58 10.75 46 80507 4960 46600549
Homicide 39.51 10.75 18 80535 428 46605081
Self esteem decreased 39.16 10.75 19 80534 523 46604986
Musculoskeletal pain 39.03 10.75 38 80515 70090 46535419
Depressive symptom 38.76 10.75 35 80518 2801 46602708
Loss of consciousness 38.65 10.75 319 80234 107919 46497590
Embolism venous 38.39 10.75 33 80520 2474 46603035
Psoriatic arthropathy 38.31 10.75 8 80545 36371 46569138
Hepatocellular injury 38.19 10.75 125 80428 29397 46576112
Insurance issue 36.99 10.75 28 80525 1750 46603759
Drooling 36.94 10.75 36 80517 3173 46602336
Osteoporosis 36.91 10.75 12 80541 40596 46564913
Self-injurious ideation 36.70 10.75 31 80522 2269 46603240
Erythema 36.67 10.75 125 80428 142695 46462814
Injection site swelling 36.51 10.75 12 80541 40315 46565194
Cognitive disorder 36.45 10.75 143 80410 36740 46568769
Device expulsion 36.25 10.75 3 80550 27539 46577970
Therapeutic product effect decreased 36.16 10.75 54 80499 82547 46522962
Dyspnoea exertional 36.00 10.75 21 80532 50268 46555241
Oropharyngeal pain 35.98 10.75 45 80508 74123 46531386
Cor pulmonale acute 35.77 10.75 16 80537 364 46605145
Muscle spasms 35.67 10.75 102 80451 123011 46482498
Torsade de pointes 35.36 10.75 70 80483 12084 46593425
Cardiac arrest 35.32 10.75 272 80281 90127 46515382
Asthenia 34.78 10.75 356 80197 310719 46294790
Stomatitis 34.66 10.75 40 80513 68257 46537252
Illusion 34.63 10.75 22 80531 1034 46604475
Psychotic disorder due to a general medical condition 34.46 10.75 13 80540 188 46605321
Neutrophil count increased 34.36 10.75 76 80477 14177 46591332
Disease progression 34.17 10.75 66 80487 91234 46514275
Head banging 34.10 10.75 16 80537 408 46605101
Megacolon 33.79 10.75 26 80527 1665 46603844
Refusal of treatment by patient 33.53 10.75 44 80509 5371 46600138
Mobility decreased 33.53 10.75 33 80520 60561 46544948
Paraesthesia 33.51 10.75 98 80455 117339 46488170
Neutrophil count decreased 33.37 10.75 156 80397 43270 46562239
Product use issue 33.22 10.75 71 80482 94573 46510936
Chills 32.91 10.75 73 80480 95959 46509550
Hot flush 32.85 10.75 17 80536 43500 46562009
Affective disorder 32.77 10.75 41 80512 4774 46600735
Anaemia 32.74 10.75 283 80270 255496 46350013
Burning sensation 32.57 10.75 18 80535 44393 46561116
Electrocardiogram T wave inversion 32.41 10.75 35 80518 3481 46602028
Myoclonic epilepsy 32.20 10.75 20 80533 903 46604606
Gamma-glutamyltransferase increased 32.13 10.75 124 80429 31616 46573893
Hypernatraemia 32.12 10.75 47 80506 6354 46599155
White blood cell count decreased 32.00 10.75 315 80238 111916 46493593
Hypokinesia 31.49 10.75 64 80489 11258 46594251
Interstitial lung disease 31.47 10.75 28 80525 53921 46551588
Cardiac failure congestive 31.23 10.75 70 80483 91680 46513829
Blood cholesterol increased 30.93 10.75 144 80409 39869 46565640
Atrial fibrillation 30.61 10.75 85 80468 103505 46502004
Electroencephalogram abnormal 30.53 10.75 35 80518 3719 46601790
Upper respiratory tract infection 30.37 10.75 39 80514 63517 46541992
Oromandibular dystonia 30.32 10.75 15 80538 431 46605078
Diabetic ketoacidosis 30.04 10.75 84 80469 18126 46587383
Impaired healing 29.82 10.75 13 80540 36730 46568779
Dyspepsia 29.74 10.75 45 80508 68427 46537082
Multiple sclerosis relapse 29.58 10.75 18 80535 42107 46563402
Waxy flexibility 29.57 10.75 10 80543 103 46605406
Abnormal clotting factor 29.40 10.75 10 80543 105 46605404
Substance abuse 29.19 10.75 36 80517 4131 46601378
Impulse-control disorder 29.07 10.75 17 80536 687 46604822
Weight decreased 28.91 10.75 229 80324 210620 46394889
Feeling guilty 28.90 10.75 15 80538 478 46605031
Depressed mood 28.83 10.75 124 80429 33195 46572314
Agranulocytosis 28.75 10.75 94 80459 22091 46583418
Menstruation irregular 28.54 10.75 45 80508 6494 46599015
Circulatory collapse 28.36 10.75 92 80461 21532 46583977
Pharyngeal dystonia 28.04 10.75 6 80547 6 46605503
Polyuria 27.99 10.75 47 80506 7148 46598361
Sudden death 27.97 10.75 55 80498 9449 46596060
Inflammation 27.65 10.75 26 80527 48755 46556754
Eosinophil count increased 27.49 10.75 49 80504 7817 46597692
Inappropriate antidiuretic hormone secretion 27.26 10.75 69 80484 14033 46591476
Throat irritation 27.24 10.75 8 80545 28893 46576616
Mental status changes 27.22 10.75 134 80419 37954 46567555
Coma scale 27.02 10.75 8 80545 51 46605458
Epilepsy 26.75 10.75 96 80457 23642 46581867
Intentional product use issue 26.68 10.75 31 80522 52749 46552760
Influenza like illness 25.82 10.75 37 80516 57533 46547976
Feeling hot 25.54 10.75 17 80536 37911 46567598
Suicidal behaviour 25.48 10.75 26 80527 2422 46603087
Myoclonus 25.47 10.75 68 80485 14284 46591225
Impulsive behaviour 25.37 10.75 21 80532 1494 46604015
Thought blocking 25.30 10.75 9 80544 109 46605400
Death 25.29 10.75 417 80136 335131 46270378
Disinhibition 25.05 10.75 17 80536 894 46604615
Plasma cell myeloma 24.86 10.75 24 80529 44454 46561055
Cataract 24.82 10.75 25 80528 45390 46560119
Acquired haemophilia 24.72 10.75 17 80536 914 46604595
Blunted affect 24.31 10.75 10 80543 184 46605325
Bone disorder 24.24 10.75 3 80550 20030 46585479
Device issue 24.16 10.75 3 80550 19977 46585532
Water intoxication 24.12 10.75 13 80540 448 46605061
Euphoric mood 23.84 10.75 33 80520 4239 46601270
Major depression 23.80 10.75 42 80511 6648 46598861
Fibromyalgia 23.68 10.75 17 80536 36446 46569063
Diverticulitis 23.36 10.75 14 80539 33025 46572484
Palpitations 23.35 10.75 85 80468 95174 46510335
Knee arthroplasty 23.33 10.75 6 80547 23659 46581850
Rhinorrhoea 23.03 10.75 29 80524 47636 46557873
Mucosal inflammation 23.01 10.75 20 80533 38956 46566553
Injection site haemorrhage 22.98 10.75 4 80549 20705 46584804
Aspartate aminotransferase increased 22.96 10.75 222 80331 78478 46527031
Electrocardiogram J wave 22.89 10.75 5 80548 6 46605503
Ketoacidosis 22.75 10.75 31 80522 3924 46601585
Hypertonia 22.71 10.75 33 80520 4433 46601076
Maternal exposure during breast feeding 22.68 10.75 26 80527 2763 46602746
Sciatica 22.65 10.75 3 80550 19017 46586492
Patient dissatisfaction with treatment 22.60 10.75 7 80546 53 46605456
Bronchitis 22.55 10.75 100 80453 105879 46499630
Accidental overdose 22.48 10.75 81 80472 19985 46585524
Meige's syndrome 22.46 10.75 5 80548 7 46605502
Unevaluable event 22.41 10.75 28 80525 46147 46559362
Pleural effusion 22.39 10.75 71 80482 82881 46522628
Musculoskeletal stiffness 22.37 10.75 90 80463 97903 46507606
Anaphylactic shock 22.31 10.75 4 80549 20270 46585239
Pain in jaw 22.28 10.75 20 80533 38352 46567157
Antiphospholipid antibodies 22.26 10.75 9 80544 158 46605351
Urinary tract infection 22.21 10.75 258 80295 220008 46385501
Differential white blood cell count abnormal 22.17 10.75 14 80539 651 46604858
Electrocardiogram J wave abnormal 22.06 10.75 5 80548 8 46605501
Limb discomfort 22.03 10.75 6 80547 22770 46582739
Polydipsia psychogenic 21.94 10.75 7 80546 59 46605450
Discomfort 21.93 10.75 29 80524 46641 46558868
Drug ineffective 21.92 10.75 952 79601 676886 45928623
Neuralgia 21.91 10.75 5 80548 21378 46584131
Skin exfoliation 21.86 10.75 15 80538 32923 46572586
Abnormal weight gain 21.71 10.75 19 80534 1459 46604050
Breast discomfort 21.65 10.75 11 80542 335 46605174
Insulin C-peptide increased 21.64 10.75 7 80546 62 46605447
Constricted affect 21.46 10.75 4 80549 0 46605509
Haemoglobin urine 21.44 10.75 8 80545 112 46605397
Drug use disorder 21.40 10.75 25 80528 2710 46602799
Cytomegalovirus infection 21.28 10.75 3 80550 18141 46587368
Skin ulcer 21.25 10.75 15 80538 32443 46573066
Retinal coloboma 21.17 10.75 6 80547 32 46605477
Poisoning deliberate 21.10 10.75 44 80509 7882 46597627
Gastrointestinal haemorrhage 21.04 10.75 66 80487 77307 46528202
Pneumonia 20.97 10.75 492 80061 375828 46229681
Pancreatitis 20.94 10.75 138 80415 43489 46562020
Fluid retention 20.79 10.75 35 80518 51011 46554498
Respiratory tract infection 20.77 10.75 13 80540 29959 46575550
Monocyte count decreased 20.77 10.75 20 80533 1737 46603772
Drug monitoring procedure incorrectly performed 20.76 10.75 8 80545 123 46605386
Behaviour disorder 20.72 10.75 21 80532 1940 46603569
Nephrolithiasis 20.70 10.75 16 80537 33035 46572474
Hyperthermia malignant 20.65 10.75 14 80539 735 46604774
Surgery 20.63 10.75 12 80541 28773 46576736
Ileus paralytic 20.62 10.75 31 80522 4292 46601217
Psychomotor skills impaired 20.57 10.75 22 80531 2164 46603345
Muscular weakness 20.56 10.75 85 80468 91759 46513750
Apallic syndrome 20.48 10.75 13 80540 610 46604899
Compulsions 20.44 10.75 9 80544 197 46605312
Akinesia 20.35 10.75 20 80533 1781 46603728
Migraine 20.28 10.75 58 80495 69968 46535541
Intentional product misuse 20.21 10.75 145 80408 46983 46558526
Psychogenic visual disorder 19.92 10.75 5 80548 15 46605494
Refusal of examination 19.91 10.75 6 80547 41 46605468
Brain injury 19.83 10.75 37 80516 6113 46599396
Staring 19.81 10.75 18 80535 1452 46604057
Bradykinesia 19.72 10.75 29 80524 3937 46601572
Thrombosis 19.72 10.75 42 80511 56027 46549482
Flat affect 19.70 10.75 17 80536 1281 46604228
Productive cough 19.55 10.75 36 80517 50679 46554830
Iris coloboma 19.54 10.75 6 80547 44 46605465
Newborn persistent pulmonary hypertension 19.52 10.75 7 80546 87 46605422
Osteonecrosis 19.52 10.75 10 80543 25734 46579775
Femur fracture 19.50 10.75 21 80532 36976 46568533
Mouth ulceration 19.50 10.75 11 80542 26821 46578688
Tubo-ovarian abscess 19.46 10.75 10 80543 312 46605197
Gastrointestinal sounds abnormal 19.44 10.75 27 80526 3479 46602030
Eosinophilia 19.39 10.75 75 80478 19142 46586367
Toxic leukoencephalopathy 19.34 10.75 12 80541 541 46604968
Withdrawal syndrome 19.30 10.75 72 80481 18062 46587447
Neoplasm progression 19.30 10.75 11 80542 26672 46578837
Insulin resistance 19.15 10.75 13 80540 684 46604825
Hallucination, visual 19.06 10.75 71 80482 17802 46587707
Product quality issue 19.05 10.75 20 80533 35628 46569881
Hypercapnia 19.05 10.75 31 80522 4595 46600914
Gastrointestinal disorder 19.03 10.75 47 80506 59529 46545980
Hip arthroplasty 19.03 10.75 4 80549 18108 46587401
Long QT syndrome 19.03 10.75 25 80528 3055 46602454
Skin discolouration 19.01 10.75 17 80536 32663 46572846
Haematochezia 18.97 10.75 22 80531 37471 46568038
Throat tightness 18.93 10.75 6 80547 20633 46584876
Nuchal rigidity 18.89 10.75 12 80541 564 46604945
Hypercholesterolaemia 18.83 10.75 53 80500 11477 46594032
Pressure of speech 18.81 10.75 12 80541 568 46604941
Impaired self-care 18.81 10.75 19 80534 1749 46603760
Tachypnoea 18.77 10.75 61 80492 14290 46591219
Ventricular dyskinesia 18.74 10.75 8 80545 162 46605347
Decreased gait velocity 18.69 10.75 4 80549 4 46605505
Pulmonary mass 18.65 10.75 4 80549 17853 46587656
Rebound psychosis 18.61 10.75 5 80548 21 46605488
Type 1 diabetes mellitus 18.57 10.75 24 80529 2886 46602623
Personality change due to a general medical condition 18.43 10.75 5 80548 22 46605487
Coagulation factor VII level decreased 18.43 10.75 5 80548 22 46605487
Bezoar 18.39 10.75 17 80536 1402 46604107
Sinus rhythm 18.35 10.75 12 80541 593 46604916
Rash pruritic 18.30 10.75 30 80523 44185 46561324
Dysgeusia 18.18 10.75 26 80527 40465 46565044
Echolalia 18.09 10.75 8 80545 177 46605332
Suspiciousness 18.08 10.75 10 80543 363 46605146
Parkinsonian gait 17.84 10.75 11 80542 490 46605019
Blister 17.81 10.75 31 80522 44600 46560909
Taciturnity 17.80 10.75 4 80549 6 46605503
Hypomagnesaemia 17.80 10.75 8 80545 22202 46583307
Bursitis 17.79 10.75 6 80547 19836 46585673
Phagophobia 17.74 10.75 5 80548 26 46605483
Caesarean section 17.74 10.75 66 80487 16537 46588972
Grandiosity 17.73 10.75 8 80545 186 46605323
Cellulitis 17.70 10.75 62 80491 70226 46535283
Fungal infection 17.61 10.75 15 80538 29505 46576004
Delusional disorder, unspecified type 17.26 10.75 10 80543 397 46605112
Hyperglycaemic hyperosmolar nonketotic syndrome 17.26 10.75 11 80542 520 46604989
Ataxia 17.14 10.75 58 80495 13872 46591637
Joint stiffness 17.14 10.75 13 80540 27095 46578414
Ketosis-prone diabetes mellitus 17.08 10.75 4 80549 8 46605501
Kidney infection 17.05 10.75 4 80549 16785 46588724
Condition aggravated 17.03 10.75 548 80005 244504 46361005
Stress 17.00 10.75 40 80513 51511 46553998
Palmar-plantar erythrodysaesthesia syndrome 16.97 10.75 7 80546 20444 46585065
Wrong drug 16.91 10.75 7 80546 131 46605378
Glutamate dehydrogenase increased 16.87 10.75 5 80548 32 46605477
Loss of personal independence in daily activities 16.83 10.75 47 80506 57136 46548373
Sinus disorder 16.72 10.75 4 80549 16559 46588950
Contusion 16.59 10.75 86 80467 87401 46518108
Wrong technique in product usage process 16.56 10.75 44 80509 54378 46551131
Hepatitis toxic 16.48 10.75 23 80530 2977 46602532
Echopraxia 16.46 10.75 4 80549 10 46605499
Grunting 16.46 10.75 8 80545 221 46605288
Extensor plantar response 16.39 10.75 15 80538 1221 46604288
Morose 16.36 10.75 5 80548 36 46605473
Genitourinary symptom 16.35 10.75 6 80547 80 46605429
Areflexia 16.35 10.75 23 80530 3000 46602509
Full blood count decreased 16.29 10.75 9 80544 22202 46583307
Hallucination, olfactory 16.23 10.75 8 80545 228 46605281
Neurosyphilis 16.09 10.75 3 80550 0 46605509
Inborn error of metabolism 16.09 10.75 3 80550 0 46605509
Excessive masturbation 16.09 10.75 3 80550 0 46605509
Intermittent explosive disorder 16.09 10.75 3 80550 0 46605509
Neonatal respiratory depression 16.08 10.75 6 80547 84 46605425
Large for dates baby 16.07 10.75 10 80543 453 46605056
Flight of ideas 15.97 10.75 9 80544 339 46605170
Microphthalmos 15.95 10.75 7 80546 152 46605357
Delusional disorder, persecutory type 15.95 10.75 7 80546 152 46605357
Ear infection 15.92 10.75 10 80543 23003 46582506
Electrocardiogram QT interval abnormal 15.91 10.75 7 80546 153 46605356
Abulia 15.85 10.75 9 80544 344 46605165
Atonic urinary bladder 15.83 10.75 6 80547 88 46605421
Overweight 15.83 10.75 23 80530 3090 46602419
Incontinence 15.78 10.75 45 80508 9817 46595692
Foot fracture 15.77 10.75 7 80546 19575 46585934
Toxic encephalopathy 15.76 10.75 30 80523 5032 46600477
Self-medication 15.73 10.75 19 80534 2133 46603376
Insomnia 15.71 10.75 384 80169 164540 46440969
Lower respiratory tract infection 15.68 10.75 46 80507 55043 46550466
Localised infection 15.58 10.75 11 80542 23790 46581719
Terminal insomnia 15.50 10.75 10 80543 483 46605026
Cardiac failure 15.50 10.75 78 80475 79870 46525639
Angina pectoris 15.49 10.75 14 80539 26761 46578748
Gastrointestinal lymphoma 15.48 10.75 5 80548 44 46605465
Autonomic nervous system imbalance 15.47 10.75 20 80533 2406 46603103
Gastric disorder 15.41 10.75 14 80539 26691 46578818
Cystitis 15.39 10.75 31 80522 42210 46563299
Rash macular 15.33 10.75 7 80546 19253 46586256
Neuroglycopenia 15.19 10.75 5 80548 47 46605462
Compulsive sexual behaviour 15.19 10.75 5 80548 47 46605462
Upper gastrointestinal haemorrhage 15.12 10.75 5 80548 16733 46588776
Drug level above therapeutic 15.11 10.75 24 80529 3485 46602024
CSF glucose increased 15.01 10.75 5 80548 49 46605460
Transient aphasia 15.01 10.75 5 80548 49 46605460
Immune-mediated encephalitis 14.74 10.75 5 80548 52 46605457
Cerebral atrophy 14.74 10.75 28 80525 4688 46600821
Amaurosis 14.73 10.75 10 80543 526 46604983
International normalised ratio abnormal 14.68 10.75 22 80531 3037 46602472
Haemorrhoids 14.68 10.75 7 80546 18770 46586739
Reduced facial expression 14.63 10.75 14 80539 1206 46604303
Joint range of motion decreased 14.60 10.75 4 80549 15120 46590389
Oral candidiasis 14.55 10.75 6 80547 17526 46587983
Affective ambivalence 14.49 10.75 4 80549 19 46605490
Pulmonary arterial hypertension 14.48 10.75 14 80539 25914 46579595
Metastases to bone 14.47 10.75 6 80547 17470 46588039
Hepatotoxicity 14.45 10.75 83 80470 24926 46580583
Feelings of worthlessness 14.42 10.75 8 80545 292 46605217
Bundle branch block right 14.31 10.75 28 80525 4791 46600718
Glassy eyes 14.25 10.75 5 80548 58 46605451
Haematocrit increased 14.23 10.75 16 80537 1664 46603845
Affect lability 14.23 10.75 38 80515 7982 46597527
Pituitary tumour benign 14.23 10.75 16 80537 1665 46603844
Stereotypy 14.22 10.75 9 80544 420 46605089
Blood pressure increased 14.09 10.75 145 80408 126521 46478988
Red blood cells urine 14.09 10.75 9 80544 427 46605082
Chronic kidney disease 14.05 10.75 31 80522 40840 46564669
Onychogryphosis 14.02 10.75 3 80550 3 46605506
Pelvic sepsis 14.02 10.75 3 80550 3 46605506
Facial wasting 14.02 10.75 3 80550 3 46605506
Analgesic drug level increased 14.00 10.75 15 80538 1479 46604030
Skin striae 13.98 10.75 13 80540 1080 46604429
Blood bilirubin increased 13.98 10.75 104 80449 34080 46571429
Suspected suicide attempt 13.94 10.75 6 80547 124 46605385
Communication disorder 13.89 10.75 19 80534 2414 46603095
Glucocorticoids increased 13.86 10.75 6 80547 126 46605383
Diabetic hyperosmolar coma 13.83 10.75 9 80544 441 46605068
Night sweats 13.78 10.75 16 80537 27234 46578275
Hypersomnia 13.77 10.75 58 80495 15381 46590128
Acute myeloid leukaemia 13.75 10.75 5 80548 15773 46589736
Helplessness 13.75 10.75 7 80546 214 46605295
Encephalitis autoimmune 13.67 10.75 13 80540 1111 46604398
Skin disorder 13.66 10.75 11 80542 22252 46583257
Myelodysplastic syndrome 13.66 10.75 5 80548 15706 46589803
Hypoventilation 13.59 10.75 25 80528 4085 46601424
Gastrooesophageal reflux disease 13.59 10.75 74 80479 74270 46531239
Opisthotonus 13.56 10.75 8 80545 329 46605180
Asphyxia 13.52 10.75 29 80524 5297 46600212
Chorea 13.52 10.75 13 80540 1127 46604382
Hospitalisation 13.50 10.75 168 80385 63217 46542292
High density lipoprotein decreased 13.38 10.75 16 80537 1778 46603731
Hostility 13.34 10.75 14 80539 1348 46604161
Hyperkalaemia 13.26 10.75 44 80509 50665 46554844
Foot deformity 13.26 10.75 5 80548 15420 46590089
Electrocardiogram abnormal 13.23 10.75 34 80519 6978 46598531
Gastric ulcer 13.17 10.75 11 80542 21852 46583657
Lactic acidosis 13.13 10.75 24 80529 33885 46571624
Leukocytosis 13.10 10.75 77 80476 23321 46582188
Brief psychotic disorder, with postpartum onset 12.95 10.75 4 80549 30 46605479
Metastases to liver 12.89 10.75 9 80544 19576 46585933
Lethargy 12.85 10.75 140 80413 51031 46554478
Blood glucose 12.83 10.75 4 80549 31 46605478
High-pitched crying 12.81 10.75 3 80550 6 46605503
Hyperinsulinism 12.81 10.75 3 80550 6 46605503
Dyskinesia neonatal 12.81 10.75 3 80550 6 46605503
Lip swelling 12.74 10.75 15 80538 25380 46580129
Brief psychotic disorder with marked stressors 12.74 10.75 5 80548 81 46605428
Hyperinsulinaemia 12.74 10.75 5 80548 81 46605428
Respiratory dyskinesia 12.72 10.75 4 80549 32 46605477
Cyclothymic disorder 12.72 10.75 4 80549 32 46605477
Fluid overload 12.66 10.75 17 80536 27168 46578341
Tic 12.63 10.75 13 80540 1223 46604286
Inappropriate affect 12.63 10.75 11 80542 839 46604670
Platelet count increased 12.59 10.75 55 80498 14819 46590690
Body mass index increased 12.56 10.75 12 80541 1032 46604477
Anterograde amnesia 12.55 10.75 8 80545 378 46605131
Deafness 12.54 10.75 6 80547 16062 46589447
Hypertransaminasaemia 12.54 10.75 22 80531 3466 46602043
Dysphonia 12.51 10.75 30 80523 38384 46567125
Pseudobulbar palsy 12.49 10.75 3 80550 7 46605502
Systemic infection 12.46 10.75 10 80543 681 46604828
Drug withdrawal syndrome neonatal 12.46 10.75 16 80537 1912 46603597
Alcohol abuse 12.45 10.75 17 80536 2155 46603354
Sluggishness 12.44 10.75 26 80527 4665 46600844
Bone marrow failure 12.40 10.75 20 80533 29649 46575860
Hyperlipidaemia 12.38 10.75 64 80489 18475 46587034
Ascites 12.37 10.75 28 80525 36556 46568953
Poverty of speech 12.34 10.75 7 80546 267 46605242
Dysbiosis 12.31 10.75 9 80544 533 46604976
Breast cancer 12.25 10.75 39 80514 45479 46560030
Breast enlargement 12.25 10.75 14 80539 1483 46604026
Device related infection 12.17 10.75 11 80542 21030 46584479
Wrong patient received product 12.15 10.75 15 80538 1722 46603787
Selective eating disorder 12.10 10.75 15 80538 1730 46603779
Lipids abnormal 12.08 10.75 7 80546 278 46605231
Oral pain 12.07 10.75 15 80538 24782 46580727
Thirst 12.03 10.75 44 80509 10932 46594577
Seasonal allergy 12.01 10.75 4 80549 13330 46592179
Speech disorder developmental 11.99 10.75 8 80545 409 46605100
Incoherent 11.95 10.75 25 80528 4487 46601022
Alveolar capillary dysplasia 11.95 10.75 3 80550 9 46605500
Cleft palate 11.91 10.75 11 80542 906 46604603
Joint effusion 11.90 10.75 3 80550 11992 46593517
Hypophagia 11.89 10.75 89 80464 29217 46576292
Blood urea decreased 11.89 10.75 17 80536 2250 46603259
Eye irritation 11.80 10.75 7 80546 16607 46588902
Antipsychotic drug level below therapeutic 11.79 10.75 7 80546 291 46605218
Moaning 11.79 10.75 10 80543 736 46604773
Somnolence neonatal 11.77 10.75 5 80548 100 46605409
Homicidal ideation 11.72 10.75 15 80538 1787 46603722
Malignant melanoma stage III 11.71 10.75 3 80550 10 46605499
Muscle tone disorder 11.68 10.75 5 80548 102 46605407
Female sexual dysfunction 11.68 10.75 4 80549 43 46605466
Tendonitis 11.66 10.75 5 80548 14272 46591237
Vomiting 11.63 10.75 651 79902 452143 46153366
Hyponatraemic syndrome 11.61 10.75 9 80544 583 46604926
Product storage error 11.61 10.75 3 80550 11789 46593720
Staphylococcal infection 11.60 10.75 28 80525 35743 46569766
Pupillary reflex impaired 11.58 10.75 16 80537 2052 46603457
Tongue biting 11.57 10.75 13 80540 1351 46604158
Personality disorder 11.57 10.75 20 80533 3113 46602396
Dependent personality disorder 11.51 10.75 4 80549 45 46605464
Crying 11.47 10.75 69 80484 21072 46584437
Neonatal seizure 11.43 10.75 7 80546 308 46605201
Suspected suicide 11.40 10.75 25 80528 4636 46600873
Amimia 11.36 10.75 4 80549 47 46605462
Distractibility 11.35 10.75 7 80546 312 46605197
Therapy partial responder 11.32 10.75 25 80528 4657 46600852
Total cholesterol/HDL ratio decreased 11.28 10.75 3 80550 12 46605497
Diabetic neuropathy 11.24 10.75 22 80531 3767 46601742
Sepsis 11.24 10.75 166 80387 135848 46469661
Dissociation 11.23 10.75 15 80538 1862 46603647
Orthostatic hypotension 11.23 10.75 77 80476 24581 46580928
Sputum discoloured 11.22 10.75 4 80549 12774 46592735
Sneezing 11.17 10.75 4 80549 12737 46592772
Prolactin-producing pituitary tumour 11.17 10.75 5 80548 114 46605395
Dry skin 11.14 10.75 35 80518 40981 46564528
Right ventricular failure 11.12 10.75 7 80546 16086 46589423
Limb injury 11.12 10.75 10 80543 19164 46586345
Malignant neoplasm progression 11.12 10.75 66 80487 64860 46540649
Drug abuser 11.12 10.75 20 80533 3213 46602296
Premature delivery 11.11 10.75 13 80540 22056 46583453
Eosinophil count abnormal 11.11 10.75 8 80545 463 46605046
Microalbuminuria 11.10 10.75 7 80546 325 46605184
Depressive delusion 11.09 10.75 3 80550 13 46605496
Product use in unapproved indication 11.07 10.75 218 80335 90055 46515454
Lipids increased 11.03 10.75 11 80542 997 46604512
Bifascicular block 10.97 10.75 5 80548 119 46605390
Heart rate decreased 10.95 10.75 24 80529 31699 46573810
Clonic convulsion 10.95 10.75 9 80544 634 46604875
Alcohol use 10.93 10.75 17 80536 2425 46603084
Visuospatial deficit 10.91 10.75 3 80550 14 46605495
Osteopenia 10.89 10.75 8 80545 16953 46588556
Acute kidney injury 10.82 10.75 317 80236 235538 46369971
Hypotonia 10.78 10.75 35 80518 8194 46597315

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1578.09 11.48 820 85227 15475 29850956
Sedation 981.54 11.48 602 85445 15771 29850660
Post-injection delirium sedation syndrome 878.35 11.48 208 85839 185 29866246
Schizophrenia 874.49 11.48 455 85592 8593 29857838
Psychotic disorder 868.53 11.48 618 85429 20897 29845534
Weight increased 623.00 11.48 912 85135 74001 29792430
Agitation 593.00 11.48 753 85294 53320 29813111
Overdose 576.83 11.48 938 85109 83399 29783032
Intentional self-injury 467.42 11.48 354 85693 13178 29853253
Aggression 456.01 11.48 546 85501 36361 29830070
Extrapyramidal disorder 449.42 11.48 315 85732 10378 29856053
Akathisia 415.84 11.48 241 85806 5663 29860768
Delusion 410.46 11.48 312 85735 11677 29854754
Suicide attempt 406.70 11.48 514 85533 36183 29830248
Hallucination, auditory 398.92 11.48 283 85764 9506 29856925
Mania 369.23 11.48 263 85784 8891 29857540
Sopor 358.65 11.48 278 85769 10713 29855718
Catatonia 319.67 11.48 183 85864 4197 29862234
Blood creatine phosphokinase increased 316.08 11.48 500 85547 43348 29823083
Prescribed overdose 304.56 11.48 228 85819 8333 29858098
Somnolence 303.18 11.48 779 85268 95984 29770447
Intentional overdose 297.58 11.48 472 85575 41009 29825422
Diabetes mellitus 294.33 11.48 472 85575 41393 29825038
Dystonia 289.35 11.48 233 85814 9494 29856937
Diarrhoea 285.22 11.48 325 85722 333778 29532653
Parkinsonism 282.04 11.48 204 85843 7065 29859366
Muscle rigidity 272.23 11.48 230 85817 10031 29856400
Toxicity to various agents 249.45 11.48 1088 84959 176095 29690336
Psychotic symptom 247.92 11.48 102 85945 1087 29865344
Tachycardia 244.75 11.48 607 85440 73132 29793299
Electrocardiogram QT prolonged 242.29 11.48 397 85650 35438 29830993
Tardive dyskinesia 238.51 11.48 160 85887 4897 29861534
Dysarthria 236.86 11.48 360 85687 30130 29836301
Arthralgia 228.00 11.48 55 85992 135736 29730695
Salivary hypersecretion 226.65 11.48 182 85865 7384 29859047
Completed suicide 225.65 11.48 713 85334 98779 29767652
Myocarditis 224.61 11.48 204 85843 9807 29856624
Delirium 217.31 11.48 406 85641 40225 29826206
Blood triglycerides increased 216.51 11.48 233 85814 13784 29852647
Restlessness 215.28 11.48 294 85753 22305 29844126
Type 2 diabetes mellitus 207.89 11.48 225 85822 13397 29853034
Oculogyric crisis 195.34 11.48 90 85957 1285 29865146
Hyperprolactinaemia 194.13 11.48 86 85961 1114 29865317
Mental impairment 188.70 11.48 179 85868 9098 29857333
Abnormal behaviour 188.42 11.48 295 85752 25328 29841103
Priapism 186.02 11.48 134 85913 4609 29861822
Dyspnoea 185.70 11.48 429 85618 332866 29533565
Metabolic syndrome 177.59 11.48 87 85960 1435 29864996
Coma 177.43 11.48 372 85675 40077 29826354
Suicidal ideation 172.43 11.48 344 85703 35770 29830661
Blood prolactin abnormal 169.71 11.48 68 85979 673 29865758
Fatigue 164.25 11.48 431 85616 320242 29546189
Rash 163.96 11.48 186 85861 191703 29674728
Hypothermia 158.33 11.48 165 85882 9402 29857029
Pain 156.75 11.48 159 85888 172482 29693949
Diabetic ketoacidosis 149.26 11.48 206 85841 15780 29850651
Depressed level of consciousness 147.65 11.48 334 85713 37888 29828543
Nausea 145.31 11.48 408 85639 296549 29569882
Paranoia 144.57 11.48 162 85885 10026 29856405
Anaemia 143.05 11.48 236 85811 207756 29658675
Anosognosia 142.88 11.48 59 85988 635 29865796
Pruritus 142.87 11.48 81 85966 118123 29748308
Blood prolactin increased 141.58 11.48 73 85974 1349 29865082
Dyskinesia 139.62 11.48 236 85811 21598 29844833
Increased appetite 136.97 11.48 120 85927 5497 29860934
Disorientation 136.65 11.48 288 85759 31130 29835301
Polydipsia 132.45 11.48 98 85949 3515 29862916
Metabolic disorder 130.26 11.48 97 85950 3514 29862917
Treatment noncompliance 129.57 11.48 248 85799 25005 29841426
Pneumonia 124.99 11.48 516 85531 333790 29532641
Bipolar disorder 122.03 11.48 95 85952 3681 29862750
Serotonin syndrome 121.92 11.48 199 85848 17692 29848739
Diabetic coma 119.48 11.48 56 85991 833 29865598
Death 119.42 11.48 575 85472 356708 29509723
Sexual dysfunction 118.64 11.48 114 85933 5887 29860544
Disturbance in social behaviour 116.90 11.48 65 85982 1406 29865025
Malignant neoplasm progression 116.00 11.48 32 86015 72255 29794176
Schizoaffective disorder 115.98 11.48 58 85989 1002 29865429
Thinking abnormal 114.77 11.48 106 85941 5205 29861226
Blood cholesterol increased 114.61 11.48 188 85859 16782 29849649
Rhabdomyolysis 112.70 11.48 420 85627 63160 29803271
Confusional state 112.48 11.48 717 85330 134117 29732314
Psychomotor hyperactivity 111.97 11.48 128 85919 8096 29858335
Cardiac failure congestive 110.63 11.48 52 85995 84355 29782076
Obesity 109.52 11.48 129 85918 8426 29858005
Cough 109.13 11.48 120 85927 125522 29740909
Emotional poverty 104.25 11.48 39 86008 315 29866116
Miosis 104.13 11.48 120 85927 7656 29858775
Granulocytopenia 104.13 11.48 108 85939 6118 29860313
Acute kidney injury 102.64 11.48 422 85625 273420 29593011
Disease progression 101.95 11.48 51 85996 79823 29786608
Antipsychotic drug level below therapeutic 101.91 11.48 58 85989 1314 29865117
Rheumatoid arthritis 100.88 11.48 4 86043 41193 29825238
Speech disorder 100.03 11.48 219 85828 24293 29842138
Disinhibition 99.74 11.48 65 85982 1892 29864539
Atrial fibrillation 98.68 11.48 99 85948 108025 29758406
Pain in extremity 98.23 11.48 103 85944 110118 29756313
Negativism 97.04 11.48 38 86009 352 29866079
Psychiatric decompensation 96.10 11.48 55 85992 1260 29865171
Febrile neutropenia 94.75 11.48 100 85947 106593 29759838
Drug interaction 93.95 11.48 930 85117 198638 29667793
Anxiety 93.69 11.48 507 85540 89364 29777067
Tremor 93.14 11.48 446 85601 74917 29791514
Obsessive-compulsive disorder 90.16 11.48 83 85964 4058 29862373
Mental disorder 89.47 11.48 148 85899 13301 29853130
Gastrointestinal haemorrhage 88.77 11.48 66 85981 83380 29783051
Headache 87.08 11.48 253 85794 182053 29684378
Plasma cell myeloma 87.01 11.48 23 86024 53439 29812992
Antipsychotic drug level above therapeutic 87.00 11.48 48 85999 1022 29865409
Hepatic steatosis 86.85 11.48 154 85893 14639 29851792
Interstitial lung disease 85.39 11.48 33 86014 60164 29806267
Renal impairment 85.23 11.48 70 85977 84114 29782317
Persecutory delusion 85.15 11.48 61 85986 2079 29864352
Drug abuse 84.86 11.48 462 85585 81610 29784821
Pneumonia aspiration 84.75 11.48 270 85777 37510 29828921
Urticaria 82.46 11.48 27 86020 54579 29811852
Psoriasis 82.34 11.48 12 86035 42494 29823937
Irritability 80.85 11.48 194 85853 22856 29843575
Joint swelling 80.70 11.48 18 86029 46928 29819503
Decreased appetite 79.12 11.48 198 85849 149712 29716719
Euphoric mood 78.27 11.48 78 85969 4212 29862219
Dyslipidaemia 77.73 11.48 89 85958 5638 29860793
Oedema peripheral 76.47 11.48 116 85931 105716 29760715
Type 1 diabetes mellitus 74.50 11.48 71 85976 3628 29862803
Leukopenia 74.24 11.48 339 85708 55820 29810611
Hypomania 73.42 11.48 57 85990 2199 29864232
Back pain 72.64 11.48 114 85933 102482 29763949
Infusion related reaction 70.84 11.48 15 86032 40549 29825882
Blepharospasm 68.39 11.48 39 86008 887 29865544
Mucosal inflammation 68.33 11.48 5 86042 30489 29835942
Neuropathy peripheral 67.20 11.48 62 85985 70413 29796018
Abdominal pain 67.12 11.48 185 85862 135469 29730962
Bradyphrenia 66.82 11.48 69 85978 3888 29862543
White blood cell count increased 65.25 11.48 256 85791 39417 29827014
Renal failure 65.21 11.48 174 85873 128792 29737639
Delusional disorder, persecutory type 64.47 11.48 26 86021 262 29866169
Peripheral swelling 64.04 11.48 49 85998 61025 29805406
Social avoidant behaviour 63.53 11.48 58 85989 2805 29863626
Drug hypersensitivity 62.17 11.48 63 85984 68456 29797975
Herpes zoster 61.50 11.48 7 86040 29936 29836495
Erythema 60.79 11.48 80 85967 77371 29789060
Respiratory depression 60.25 11.48 114 85933 11389 29855042
Dyspnoea exertional 60.06 11.48 14 86033 35416 29831015
Psychiatric symptom 59.01 11.48 60 85987 3319 29863112
Stomatitis 58.85 11.48 17 86030 37262 29829169
Antipsychotic drug level increased 58.57 11.48 58 85989 3108 29863323
Septic shock 58.26 11.48 58 85989 63549 29802882
Drooling 57.35 11.48 56 85991 2949 29863482
Obsessive thoughts 57.04 11.48 31 86016 640 29865791
International normalised ratio increased 55.79 11.48 34 86013 47705 29818726
Bradykinesia 55.76 11.48 57 85990 3173 29863258
Tension 55.46 11.48 42 86005 1561 29864870
Depressive symptom 54.49 11.48 42 86005 1603 29864828
Visceral congestion 54.37 11.48 28 86019 516 29865915
Sinus tachycardia 53.83 11.48 130 85917 15374 29851057
Anticholinergic syndrome 53.70 11.48 32 86015 792 29865639
Eosinophilic myocarditis 53.50 11.48 26 86021 421 29866010
Influenza 53.43 11.48 29 86018 43369 29823062
Apathy 53.25 11.48 77 85970 6155 29860276
Hyperglycaemia 52.99 11.48 221 85826 34979 29831452
Haemorrhage 52.22 11.48 34 86013 46045 29820386
Hyperkalaemia 51.98 11.48 68 85979 65942 29800489
Withdrawal syndrome 51.07 11.48 105 85942 11145 29855286
Spasmodic dysphonia 50.98 11.48 16 86031 70 29866361
Water intoxication 50.64 11.48 26 86021 476 29865955
Cerebrovascular accident 49.87 11.48 103 85944 83374 29783057
Hallucination 49.87 11.48 275 85772 48784 29817647
Melaena 49.03 11.48 16 86031 32421 29834010
Neutrophil count increased 48.48 11.48 124 85923 15199 29851232
Agranulocytosis 48.45 11.48 156 85891 21786 29844645
Infection 47.78 11.48 95 85952 77979 29788452
Refusal of treatment by patient 46.97 11.48 65 85982 4988 29861443
Self-injurious ideation 46.68 11.48 38 86009 1571 29864860
Mutism 46.18 11.48 28 86019 716 29865715
Hyperammonaemia 45.42 11.48 67 85980 5453 29860978
Derealisation 45.07 11.48 25 86022 538 29865893
Pleurothotonus 44.98 11.48 31 86016 992 29865439
Loss of consciousness 44.83 11.48 385 85662 78990 29787441
Sudden death 44.56 11.48 121 85926 15371 29851060
Asthenia 44.45 11.48 414 85633 220876 29645555
Grandiosity 44.23 11.48 21 86026 322 29866109
Cognitive disorder 44.03 11.48 159 85888 23531 29842900
Logorrhoea 43.91 11.48 41 86006 2041 29864390
Unresponsive to stimuli 43.85 11.48 171 85876 26248 29840183
Therapeutic product effect variable 42.84 11.48 34 86013 1355 29865076
Delusion of grandeur 42.83 11.48 21 86026 347 29866084
Chills 42.58 11.48 90 85957 72248 29794183
Pleural effusion 42.07 11.48 94 85953 73972 29792459
Hanging 41.82 11.48 15 86032 106 29866325
Sepsis 41.75 11.48 248 85799 146147 29720284
Suspiciousness 41.72 11.48 21 86026 368 29866063
Delusion of replacement 41.65 11.48 16 86031 140 29866291
Myocardial infarction 41.24 11.48 203 85844 125422 29741009
Xanthoma 40.98 11.48 14 86033 84 29866347
Hypertriglyceridaemia 40.86 11.48 79 85968 8019 29858412
Cytomegalovirus infection 40.83 11.48 9 86038 23665 29842766
Musculoskeletal pain 40.60 11.48 19 86028 30921 29835510
Insomnia 40.43 11.48 428 85619 92908 29773523
Feeling guilty 40.39 11.48 19 86028 285 29866146
Cardiac failure 40.30 11.48 115 85932 83303 29783128
Acute myocardial infarction 40.19 11.48 56 85991 52883 29813548
Nasopharyngitis 40.11 11.48 67 85980 58782 29807649
Hyperreflexia 40.02 11.48 45 86002 2794 29863637
Blood glucose increased 39.89 11.48 308 85739 61222 29805209
Weight decreased 39.77 11.48 262 85785 150659 29715772
Abdominal discomfort 39.72 11.48 49 85998 48742 29817689
Product dose omission issue 39.54 11.48 133 85914 91498 29774933
Thrombosis 39.25 11.48 38 86009 42193 29824238
General physical health deterioration 39.19 11.48 151 85896 99793 29766638
Blood creatinine increased 39.17 11.48 133 85914 91242 29775189
Inappropriate affect 38.97 11.48 23 86024 559 29865872
Hallucination, visual 38.74 11.48 118 85929 15995 29850436
Breast engorgement 38.54 11.48 9 86038 7 29866424
Coronary artery disease 38.33 11.48 52 85995 49660 29816771
Prostate cancer 37.67 11.48 11 86036 23946 29842485
Arthropathy 37.58 11.48 7 86040 20720 29845711
Pneumonitis 37.37 11.48 16 86031 27438 29838993
Eosinophil count decreased 37.15 11.48 29 86018 1128 29865303
Diabetic hyperosmolar coma 37.09 11.48 19 86028 346 29866085
Stupor 36.92 11.48 44 86003 2909 29863522
Eye movement disorder 36.82 11.48 51 85996 3917 29862514
Asthma 36.68 11.48 30 86017 36144 29830287
Haemoglobin decreased 36.51 11.48 186 85861 113912 29752519
Chronic kidney disease 36.40 11.48 33 86014 37805 29828626
Ascites 36.16 11.48 30 86017 35891 29830540
Aspiration 36.12 11.48 88 85959 10463 29855968
Sedation complication 36.03 11.48 25 86022 809 29865622
Diverticulitis 36.02 11.48 4 86043 17441 29848990
Angina pectoris 35.93 11.48 20 86027 29498 29836933
Psychomotor retardation 35.76 11.48 39 86008 2340 29864091
Gout 35.67 11.48 4 86043 17311 29849120
Faecaloma 35.57 11.48 53 85994 4352 29862079
Anaphylactic reaction 35.47 11.48 18 86029 27964 29838467
Arthritis 35.21 11.48 13 86034 24388 29842043
Disturbance in attention 34.93 11.48 141 85906 21988 29844443
Torticollis 34.63 11.48 27 86020 1048 29865383
Drug withdrawal syndrome neonatal 34.37 11.48 44 86003 3131 29863300
Bipolar I disorder 34.36 11.48 24 86023 785 29865646
Multiple organ dysfunction syndrome 34.10 11.48 83 85964 63404 29803027
Cold-stimulus headache 33.99 11.48 7 86040 0 29866431
Psychotic behaviour 33.89 11.48 20 86027 486 29865945
Megacolon 33.74 11.48 32 86015 1625 29864806
Cardiomyopathy 33.73 11.48 108 85939 15035 29851396
Hypersensitivity 33.68 11.48 65 85982 53963 29812468
Ataxia 33.44 11.48 90 85957 11372 29855059
Sinusitis 33.38 11.48 28 86019 33317 29833114
Angioedema 33.06 11.48 30 86017 34354 29832077
Ketoacidosis 33.06 11.48 47 86000 3699 29862732
Eosinophil count increased 33.04 11.48 69 85978 7404 29859027
Generalised tonic-clonic seizure 32.81 11.48 127 85920 19424 29847007
Food craving 32.78 11.48 17 86030 318 29866113
Antisocial behaviour 32.60 11.48 16 86031 265 29866166
Haematuria 32.48 11.48 49 85998 44785 29821646
Delusional disorder, unspecified type 32.43 11.48 23 86024 771 29865660
Pancytopenia 32.38 11.48 130 85917 84922 29781509
Colitis ischaemic 32.37 11.48 59 85988 5727 29860704
Posture abnormal 32.37 11.48 33 86014 1831 29864600
Hyponatraemia 32.36 11.48 315 85732 66887 29799544
Obsessive-compulsive symptom 32.34 11.48 11 86036 65 29866366
Hyperbilirubinaemia 32.30 11.48 5 86042 16937 29849494
Coma scale abnormal 32.24 11.48 44 86003 3332 29863099
Injection site pain 32.17 11.48 24 86023 30286 29836145
Withdrawal catatonia 32.06 11.48 11 86036 67 29866364
Staphylococcal infection 31.99 11.48 24 86023 30200 29836231
Oral discharge 31.97 11.48 13 86034 134 29866297
Colitis 31.95 11.48 25 86022 30795 29835636
Physical assault 31.77 11.48 27 86020 1186 29865245
Rebound psychosis 31.64 11.48 13 86034 138 29866293
Nephrolithiasis 31.39 11.48 16 86031 24794 29841637
Intentional product use issue 31.37 11.48 35 86012 36405 29830026
Cogwheel rigidity 31.22 11.48 26 86021 1110 29865321
Somatic symptom disorder 31.22 11.48 19 86028 489 29865942
Skin exfoliation 30.76 11.48 14 86033 23158 29843273
Hunger 30.70 11.48 28 86019 1352 29865079
Acute psychosis 30.40 11.48 32 86015 1844 29864587
Hypercholesterolaemia 30.02 11.48 67 85980 7525 29858906
Personality change 29.76 11.48 50 85997 4550 29861881
Dyspepsia 29.71 11.48 26 86021 30303 29836128
Incoherent 29.67 11.48 47 86000 4071 29862360
Hyperphagia 29.53 11.48 27 86020 1308 29865123
Wrong patient received product 29.45 11.48 31 86016 1786 29864645
Hospitalisation 29.36 11.48 223 85824 44096 29822335
Myalgia 29.30 11.48 117 85930 76550 29789881
Blunted affect 29.29 11.48 15 86032 273 29866158
Overweight 29.27 11.48 28 86019 1437 29864994
Paradoxical embolism 29.13 11.48 6 86041 0 29866431
Unevaluable event 29.07 11.48 29 86018 31756 29834675
Cerebrovascular stenosis 29.07 11.48 11 86036 92 29866339
Hyperlipidaemia 29.01 11.48 97 85950 13810 29852621
Agitated depression 28.79 11.48 14 86033 227 29866204
Mydriasis 28.67 11.48 58 85989 6085 29860346
Wheezing 28.56 11.48 28 86019 30910 29835521
Flat affect 28.56 11.48 22 86025 839 29865592
Judgement impaired 28.40 11.48 20 86027 663 29865768
Urinary incontinence 28.39 11.48 110 85937 16830 29849601
Muscular weakness 28.39 11.48 91 85956 63554 29802877
Pressure of speech 28.38 11.48 17 86030 425 29866006
Altered state of consciousness 28.37 11.48 123 85924 19796 29846635
Swelling 28.37 11.48 37 86010 35938 29830493
Pulmonary embolism 28.27 11.48 346 85701 77789 29788642
Candida infection 28.25 11.48 5 86042 15357 29851074
Perseveration 28.17 11.48 11 86036 101 29866330
Neutropenia 28.09 11.48 522 85525 128018 29738413
Long QT syndrome 27.92 11.48 34 86013 2299 29864132
Osteoarthritis 27.82 11.48 9 86038 18340 29848091
Hyperhidrosis 27.80 11.48 305 85742 66785 29799646
Fluid retention 27.57 11.48 19 86028 24979 29841452
Product substitution issue 27.49 11.48 77 85970 9958 29856473
Electroencephalogram abnormal 27.45 11.48 34 86013 2340 29864091
Bronchitis 27.16 11.48 44 86003 39081 29827350
Dysgeusia 27.15 11.48 19 86028 24782 29841649
Myelodysplastic syndrome 27.10 11.48 10 86037 18768 29847663
Full blood count decreased 27.05 11.48 6 86041 15711 29850720
Staring 26.97 11.48 27 86020 1466 29864965
Dysphagia 26.92 11.48 265 85782 56433 29809998
Autonomic nervous system imbalance 26.91 11.48 34 86013 2387 29864044
Alanine aminotransferase increased 26.91 11.48 329 85718 73947 29792484
Choreoathetosis 26.79 11.48 22 86025 921 29865510
Illness anxiety disorder 26.77 11.48 12 86035 160 29866271
Osteonecrosis of jaw 26.73 11.48 10 86037 18608 29847823
Tubulointerstitial nephritis 26.73 11.48 9 86038 17882 29848549
Muscle spasms 26.68 11.48 96 85951 64742 29801689
Camptocormia 26.64 11.48 12 86035 162 29866269
Productive cough 26.63 11.48 28 86019 29925 29836506
Urinary tract infection 26.53 11.48 115 85932 73544 29792887
Enuresis 26.52 11.48 29 86018 1745 29864686
Depression 26.32 11.48 385 85662 90052 29776379
Troponin increased 26.30 11.48 70 85977 8787 29857644
Hypertonia 26.18 11.48 46 86001 4339 29862092
Dehydration 26.11 11.48 228 85819 123311 29743120
Protrusion tongue 26.02 11.48 13 86034 224 29866207
Erectile dysfunction 25.95 11.48 112 85935 17990 29848441
Cerebellar syndrome 25.87 11.48 31 86016 2061 29864370
Chronic obstructive pulmonary disease 25.80 11.48 59 85988 46067 29820364
Leukocytosis 25.61 11.48 126 85921 21376 29845055
Pulmonary fibrosis 25.53 11.48 7 86040 15883 29850548
Behaviour disorder 25.44 11.48 33 86014 2379 29864052
Haematoma 25.37 11.48 19 86028 23934 29842497
Aspartate aminotransferase increased 25.22 11.48 286 85761 63136 29803295
Poisoning 25.19 11.48 81 85966 11301 29855130
Symptom masked 25.13 11.48 16 86031 447 29865984
Epistaxis 24.87 11.48 74 85973 52907 29813524
Oedema 24.86 11.48 54 85993 42939 29823492
Delusional perception 24.65 11.48 11 86036 145 29866286
Salivary gland calculus 24.46 11.48 8 86039 41 29866390
Waxy flexibility 24.43 11.48 10 86037 105 29866326
Osteonecrosis 24.31 11.48 8 86039 16127 29850304
Prostatic specific antigen increased 24.17 11.48 3 86044 12001 29854430
Dementia with Lewy bodies 24.15 11.48 17 86030 563 29865868
Depressed mood 24.13 11.48 105 85942 16924 29849507
Hyperglycaemic hyperosmolar nonketotic syndrome 24.13 11.48 21 86026 953 29865478
Metastases to liver 24.06 11.48 3 86044 11962 29854469
Respiratory arrest 23.94 11.48 155 85892 29103 29837328
Rhinorrhoea 23.93 11.48 15 86032 20739 29845692
Hepatic failure 23.90 11.48 38 86009 34005 29832426
Malignant catatonia 23.86 11.48 10 86037 112 29866319
Neoplasm progression 23.75 11.48 11 86036 18012 29848419
Exhibitionism 23.56 11.48 8 86039 47 29866384
Poisoning deliberate 23.23 11.48 52 85995 5852 29860579
Body temperature increased 23.18 11.48 94 85953 14686 29851745
Hallucinations, mixed 23.17 11.48 32 86015 2451 29863980
Impaired self-care 23.16 11.48 20 86027 898 29865533
Hypotonia neonatal 23.13 11.48 21 86026 1008 29865423
Palmar-plantar erythrodysaesthesia syndrome 23.07 11.48 7 86040 14863 29851568
Neutrophil count decreased 22.94 11.48 204 85843 42250 29824181
Disorganised speech 22.65 11.48 16 86031 533 29865898
Bronchopulmonary aspergillosis 22.59 11.48 4 86043 12280 29854151
Selective eating disorder 22.56 11.48 26 86021 1658 29864773
Compulsive sexual behaviour 22.51 11.48 12 86035 238 29866193
Ileus paralytic 22.50 11.48 50 85997 5598 29860833
Impulsive behaviour 22.49 11.48 28 86019 1937 29864494
Drug monitoring procedure incorrectly performed 22.47 11.48 11 86036 181 29866250
Patient restraint 22.47 11.48 9 86038 89 29866342
Hallucination, olfactory 22.42 11.48 11 86036 182 29866249
Thrombocytopenia 22.33 11.48 269 85778 136775 29729656
High density lipoprotein decreased 22.26 11.48 36 86011 3174 29863257
Acute myeloid leukaemia 22.20 11.48 12 86035 17994 29848437
Heat stroke 22.04 11.48 19 86028 851 29865580
Tumour lysis syndrome 22.01 11.48 5 86042 12880 29853551
Myoclonus 21.95 11.48 86 85961 13226 29853205
COVID-19 21.92 11.48 12 86035 17866 29848565
Pancreatitis haemorrhagic 21.91 11.48 13 86034 319 29866112
Homicidal ideation 21.88 11.48 31 86016 2432 29863999
Drug level above therapeutic 21.81 11.48 34 86013 2905 29863526
Chest discomfort 21.73 11.48 63 85984 45417 29821014
Dysphonia 21.61 11.48 14 86033 19018 29847413
Asphyxia 21.59 11.48 48 85999 5377 29861054
Mental status changes 21.51 11.48 181 85866 36898 29829533
Total cholesterol/HDL ratio increased 21.50 11.48 10 86037 146 29866285
Rash pruritic 21.33 11.48 20 86027 22552 29843879
Gamma-glutamyltransferase increased 21.33 11.48 151 85896 29199 29837232
Bacteraemia 21.28 11.48 9 86038 15551 29850880
Renal disorder 21.02 11.48 22 86025 23562 29842869
Polyuria 20.94 11.48 57 85990 7249 29859182
Blood ketone body 20.93 11.48 8 86039 69 29866362
White blood cell count decreased 20.85 11.48 348 85699 83599 29782832
Transient ischaemic attack 20.83 11.48 25 86022 25175 29841256
Drug level increased 20.76 11.48 106 85941 18248 29848183
Inappropriate antidiuretic hormone secretion 20.66 11.48 76 85971 11346 29855085
Alcohol use 20.64 11.48 38 86009 3717 29862714
Haematochezia 20.61 11.48 42 86005 34180 29832251
Abdominal pain upper 20.54 11.48 101 85946 62450 29803981
C-reactive protein increased 20.54 11.48 203 85844 43270 29823161
Coagulopathy 20.45 11.48 14 86033 18473 29847958
Hepatitis C virus test positive 20.45 11.48 14 86033 443 29865988
Stereotypy 20.39 11.48 15 86032 533 29865898
Panic attack 20.33 11.48 63 85984 8618 29857813
Clostridium difficile infection 20.23 11.48 10 86037 15773 29850658
Circadian rhythm sleep disorder 20.17 11.48 13 86034 371 29866060
Somatic hallucination 20.17 11.48 6 86041 21 29866410
Neurodegenerative disorder 20.07 11.48 11 86036 231 29866200
Fungal infection 20.04 11.48 7 86040 13593 29852838
Confabulation 19.95 11.48 9 86038 122 29866309
Upper respiratory tract infection 19.93 11.48 30 86017 27446 29838985
Suicidal behaviour 19.90 11.48 22 86025 1340 29865091
Clostridium difficile colitis 19.82 11.48 6 86041 12762 29853669
Hyperthermia 19.80 11.48 69 85978 10030 29856401
Brain injury 19.77 11.48 47 86000 5501 29860930
Lymphocyte count increased 19.70 11.48 30 86017 2512 29863919
Condition aggravated 19.69 11.48 527 85520 137339 29729092
Abulia 19.57 11.48 14 86033 476 29865955
Somnambulism 19.56 11.48 34 86013 3180 29863251
Pancreatitis necrotising 19.48 11.48 29 86018 2380 29864051
Blood thrombin increased 19.42 11.48 4 86043 0 29866431
Affect lability 19.31 11.48 35 86012 3383 29863048
Bone marrow failure 19.29 11.48 35 86012 29750 29836681
Pyrexia 19.21 11.48 673 85374 293816 29572615
Affective disorder 19.07 11.48 33 86014 3075 29863356
Rash erythematous 18.85 11.48 22 86025 22430 29844001
Respiration abnormal 18.82 11.48 30 86017 2612 29863819
Globulins decreased 18.82 11.48 10 86037 197 29866234
Major depression 18.80 11.48 38 86009 3984 29862447
Depersonalisation/derealisation disorder 18.66 11.48 14 86033 513 29865918
Skin ulcer 18.65 11.48 16 86031 18833 29847598
Galactorrhoea 18.60 11.48 12 86035 343 29866088
Gait disturbance 18.57 11.48 310 85737 74467 29791964
Asocial behaviour 18.45 11.48 7 86040 59 29866372
Flatulence 18.42 11.48 15 86032 18114 29848317
Pain in jaw 18.36 11.48 6 86041 12150 29854281
Laboratory test abnormal 18.26 11.48 14 86033 17428 29849003
Proteinuria 18.16 11.48 12 86035 16133 29850298
Soliloquy 18.06 11.48 12 86035 361 29866070
Electrocardiogram QT shortened 17.92 11.48 9 86038 157 29866274
Eosinophilia 17.88 11.48 117 85930 22043 29844388
Bone pain 17.81 11.48 17 86030 19009 29847422
Osteomyelitis 17.79 11.48 10 86037 14671 29851760
Neoplasm malignant 17.78 11.48 15 86032 17799 29848632
Anaphylactic shock 17.74 11.48 9 86038 13984 29852447
Cerebral haemorrhage 17.65 11.48 43 86004 32844 29833587
Alcohol abuse 17.64 11.48 44 86003 5309 29861122
Dysphoria 17.57 11.48 26 86021 2122 29864309
Sluggishness 17.52 11.48 32 86015 3111 29863320
Squamous cell carcinoma 17.47 11.48 4 86043 10246 29856185
Polydipsia psychogenic 17.44 11.48 8 86039 113 29866318
Injection site erythema 17.38 11.48 9 86038 13825 29852606
Embolism venous 17.34 11.48 20 86027 1277 29865154
Blood bilirubin increased 17.32 11.48 51 85996 36585 29829846
Hepatitis viral 17.24 11.48 13 86034 480 29865951
Pulmonary valve incompetence 17.21 11.48 15 86032 682 29865749
Multiple drug therapy 17.17 11.48 10 86037 237 29866194
Vascular stenosis 17.13 11.48 9 86038 173 29866258
Impaired healing 17.04 11.48 10 86037 14330 29852101
Upper gastrointestinal haemorrhage 17.01 11.48 23 86024 22005 29844426
Lens dislocation 16.92 11.48 5 86042 17 29866414
Gastrointestinal hypermotility 16.89 11.48 8 86039 122 29866309
Anger 16.87 11.48 70 85977 11050 29855381
Snoring 16.84 11.48 30 86017 2861 29863570
Head banging 16.83 11.48 8 86039 123 29866308
Dyspraxia 16.76 11.48 10 86037 248 29866183
Malaise 16.72 11.48 359 85688 166603 29699828
Lipids increased 16.69 11.48 17 86030 942 29865489
Sleep disorder 16.67 11.48 124 85923 24355 29842076
Hyperosmolar state 16.67 11.48 12 86035 412 29866019
Bladder cancer 16.66 11.48 3 86044 9099 29857332
Parkinsonian rest tremor 16.60 11.48 8 86039 127 29866304
Blister 16.59 11.48 21 86026 20662 29845769
Myoglobin blood increased 16.57 11.48 23 86024 1770 29864661
Drug ineffective 16.54 11.48 1162 84885 339225 29527206
Glassy eyes 16.50 11.48 7 86040 81 29866350
Blood creatine phosphokinase MB increased 16.47 11.48 24 86023 1932 29864499
Movement disorder 16.42 11.48 64 85983 9819 29856612
Cerebellar atrophy 16.40 11.48 12 86035 423 29866008
Haemoptysis 16.39 11.48 41 86006 31037 29835394
Cyclothymic disorder 16.35 11.48 7 86040 83 29866348
Haemophagocytic lymphohistiocytosis 16.33 11.48 4 86043 9787 29856644
Neglect of personal appearance 16.33 11.48 8 86039 132 29866299
Ageusia 16.28 11.48 3 86044 8950 29857481
Jaundice 16.26 11.48 44 86003 32442 29833989
Lung disorder 16.22 11.48 42 86005 31427 29835004
Myotonia 16.20 11.48 6 86041 47 29866384
Faeces discoloured 16.19 11.48 10 86037 13936 29852495
Ejaculation disorder 16.10 11.48 17 86030 983 29865448
Vascular encephalopathy 15.99 11.48 7 86040 88 29866343
Contusion 15.93 11.48 42 86005 31238 29835193
Antisocial personality disorder 15.91 11.48 5 86042 22 29866409
Rebound effect 15.91 11.48 21 86026 1540 29864891
Gastrectomy 15.90 11.48 8 86039 140 29866291
Motor dysfunction 15.88 11.48 45 86002 5857 29860574
Generalised anxiety disorder 15.85 11.48 14 86033 648 29865783
Paraphilia 15.85 11.48 7 86040 90 29866341
Peritonitis 15.83 11.48 23 86024 21352 29845079
Dry skin 15.82 11.48 25 86022 22429 29844002
Selective mutism 15.77 11.48 6 86041 51 29866380
Hostility 15.76 11.48 16 86031 883 29865548
Abnormal weight gain 15.65 11.48 16 86031 891 29865540
Pulmonary hypertension 15.61 11.48 19 86028 19017 29847414
Drug use disorder 15.55 11.48 31 86016 3217 29863214
Angina unstable 15.48 11.48 8 86039 12302 29854129
Thrombotic microangiopathy 15.41 11.48 3 86044 8607 29857824
Graft versus host disease 15.35 11.48 5 86042 10145 29856286
Basophil count decreased 15.19 11.48 7 86040 100 29866331
Treatment failure 15.17 11.48 50 85997 34629 29831802
Cellulitis 15.09 11.48 76 85971 46708 29819723
Secondary tic 15.05 11.48 4 86043 8 29866423
Renal tubular necrosis 15.02 11.48 13 86034 15238 29851193
Device related infection 15.02 11.48 16 86031 16999 29849432
Thirst 14.97 11.48 49 85998 6900 29859531
Paranoid personality disorder 14.92 11.48 5 86042 28 29866403
Frequent bowel movements 14.89 11.48 3 86044 8402 29858029
Epilepsy 14.79 11.48 104 85943 20065 29846366
Mobility decreased 14.74 11.48 33 86014 25966 29840465
Flushing 14.72 11.48 40 86007 29452 29836979
Cholestasis 14.70 11.48 31 86016 24919 29841512
Chromaturia 14.68 11.48 11 86036 13854 29852577
Gastrointestinal sounds abnormal 14.67 11.48 23 86024 1975 29864456
Hyperammonaemic encephalopathy 14.62 11.48 22 86025 1822 29864609
Skin lesion 14.60 11.48 19 86028 18475 29847956
Schizoid personality disorder 14.57 11.48 3 86044 0 29866431
Hyperinsulinism 14.49 11.48 6 86041 65 29866366
Tangentiality 14.42 11.48 7 86040 113 29866318
Tic 14.38 11.48 23 86024 2009 29864422
Trismus 14.37 11.48 25 86022 2340 29864091
Electrocardiogram PR prolongation 14.34 11.48 14 86033 737 29865694
Contraindicated product administered 14.34 11.48 17 86030 17214 29849217
Wrong technique in product usage process 14.27 11.48 44 86003 31111 29835320
Urinary retention 14.25 11.48 151 85896 32766 29833665
Ventricular hypokinesia 14.22 11.48 35 86012 4188 29862243
Metastases to bone 14.18 11.48 5 86042 9653 29856778
Cataract congenital 14.18 11.48 6 86041 69 29866362
Inflammation 14.16 11.48 26 86021 22000 29844431
Chemical poisoning 14.10 11.48 7 86040 119 29866312
Personality disorder 14.09 11.48 17 86030 1138 29865293
Illusion 14.08 11.48 14 86033 754 29865677
Diabetes insipidus 14.04 11.48 24 86023 2215 29864216
Respiratory failure 14.02 11.48 204 85843 100438 29765993
Pseudoporphyria 13.90 11.48 9 86038 259 29866172
Reduced facial expression 13.89 11.48 14 86033 766 29865665
Thought blocking 13.89 11.48 7 86040 123 29866308
Glycosylated haemoglobin increased 13.81 11.48 59 85988 9432 29856999
Gynaecomastia 13.81 11.48 54 85993 8297 29858134
Incontinence 13.74 11.48 40 86007 5286 29861145
Oral pain 13.74 11.48 5 86042 9464 29856967
Posterior reversible encephalopathy syndrome 13.68 11.48 4 86043 8703 29857728
Mixed delusion 13.67 11.48 4 86043 13 29866418
Eczema 13.66 11.48 11 86036 13358 29853073
Coordination abnormal 13.54 11.48 49 85998 7256 29859175
Blood cholesterol abnormal 13.53 11.48 18 86029 1330 29865101
Joint stiffness 13.48 11.48 5 86042 9356 29857075
Pancreatic carcinoma 13.47 11.48 3 86044 7834 29858597
Echolalia 13.42 11.48 8 86039 198 29866233
Tricuspid valve sclerosis 13.41 11.48 5 86042 40 29866391
Resting tremor 13.32 11.48 12 86035 570 29865861
Strabismus congenital 13.30 11.48 5 86042 41 29866390
Intestinal perforation 13.23 11.48 4 86043 8515 29857916
Oropharyngeal pain 13.23 11.48 40 86007 28456 29837975
Hypotonia 13.22 11.48 47 86000 6901 29859530
Blood cholesterol decreased 13.18 11.48 15 86032 944 29865487
Foetal arrhythmia 13.06 11.48 6 86041 85 29866346
Blood creatine phosphokinase decreased 13.04 11.48 11 86036 478 29865953
Rash maculo-papular 13.04 11.48 34 86013 25384 29841047
Pathogen resistance 12.97 11.48 4 86043 8406 29858025
Blood loss anaemia 12.95 11.48 3 86044 7624 29858807
Neuralgia 12.87 11.48 7 86040 10459 29855972
Substance abuse 12.86 11.48 47 86000 6993 29859438
Drug eruption 12.84 11.48 19 86028 17507 29848924
Acetonaemia 12.82 11.48 6 86041 89 29866342
Disseminated intravascular coagulation 12.69 11.48 28 86019 22143 29844288
Cardiogenic shock 12.63 11.48 18 86029 16843 29849588
Transfusion 12.54 11.48 3 86044 7458 29858973
Seizure 12.53 11.48 371 85676 98104 29768327
Glutamate dehydrogenase increased 12.50 11.48 3 86044 3 29866428
Inferiority complex 12.50 11.48 3 86044 3 29866428
Oliguria 12.48 11.48 3 86044 7436 29858995
Velopharyngeal incompetence 12.48 11.48 4 86043 19 29866412
Malignant melanoma 12.41 11.48 3 86044 7408 29859023
Hypoaesthesia 12.38 11.48 98 85949 54132 29812299
Haemorrhage intracranial 12.33 11.48 15 86032 15017 29851414
Ear infection 12.32 11.48 3 86044 7371 29859060
Eyelid bleeding 12.31 11.48 4 86043 20 29866411
Retrognathia 12.30 11.48 8 86039 232 29866199
Rectal haemorrhage 12.30 11.48 55 85992 34884 29831547
Family stress 12.28 11.48 7 86040 159 29866272
Paradoxical drug reaction 12.26 11.48 25 86022 2637 29863794
Injection site bruising 12.23 11.48 3 86044 7335 29859096
Myelosuppression 12.19 11.48 3 86044 7319 29859112
Drug withdrawal syndrome 12.19 11.48 98 85949 19711 29846720
Hypomagnesaemia 12.15 11.48 18 86029 16580 29849851
Pharyngeal dyskinesia 12.15 11.48 4 86043 21 29866410
Cataract 12.15 11.48 28 86019 21807 29844624
Gastric haemorrhage 12.13 11.48 6 86041 9461 29856970
Hypokinesia 12.05 11.48 47 86000 7213 29859218
Tachyphrenia 12.01 11.48 15 86032 1041 29865390
Antidepressant drug level increased 11.98 11.48 6 86041 104 29866327
Sexually inappropriate behaviour 11.96 11.48 9 86038 331 29866100
Erythema multiforme 11.96 11.48 4 86043 7981 29858450
Osteoporosis 11.90 11.48 8 86039 10655 29855776
Dextrocardia 11.86 11.48 7 86040 170 29866261
Encephalitis autoimmune 11.83 11.48 10 86037 436 29865995
Helplessness 11.78 11.48 5 86042 58 29866373
Foetal heart rate abnormal 11.76 11.48 7 86040 173 29866258
Cardiac septal hypertrophy 11.75 11.48 8 86039 251 29866180
Chest pain 11.74 11.48 253 85794 117374 29749057
Breathing-related sleep disorder 11.72 11.48 7 86040 174 29866257
Phlebitis superficial 11.72 11.48 8 86039 252 29866179
Blood creatine decreased 11.70 11.48 5 86042 59 29866372
Drug level decreased 11.68 11.48 40 86007 5765 29860666
Clumsiness 11.65 11.48 17 86030 1370 29865061
Negative thoughts 11.58 11.48 12 86035 679 29865752
Platelet count decreased 11.56 11.48 225 85822 105904 29760527
Cholangitis 11.52 11.48 4 86043 7798 29858633
Pseudomonas infection 11.51 11.48 8 86039 10474 29855957

Pharmacologic Action:

SourceCodeDescription
ATC N05AH03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37956 histamine receptor blocker
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:48876 antimuskarinika
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:50949 serotonin reuptake inhibitor
CHEBI has role CHEBI:65191 atypical antipsychotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Major depressive disorder indication 370143000
Depression Treatment Adjunct indication
Agitation associated with Bipolar Mania indication
Agitation associated with Schizophrenia indication
Nausea and vomiting off-label use 16932000
Feeling agitated off-label use 24199005
Migraine off-label use 37796009 DOID:6364
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Chemotherapy-induced nausea and vomiting off-label use 236084000
cannabinoid hyperememsis off-label use 11047881000119100
cannabinoid hyperememsis off-label use 11048011000119100
Delirium contraindication 2776000
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Sedation contraindication 72641008
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.72 Basic
pKa3 0.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.32 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.52 WOMBAT-PK CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.70 IUPHAR
Sodium-dependent serotonin transporter Transporter Ki 6.26 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.59 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Kd 5.90 CHEMBL
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 1F GPCR Ki 6.51 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel Ki 6.69 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.54 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 6.12 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.22 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 8.05 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.68 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.14 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.10 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.51 WOMBAT-PK
Histamine H2 receptor GPCR Ki 7.36 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.15 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.09 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.72 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.98 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.92 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.74 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.49 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 7.40 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.92 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 6.43 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.56 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.68 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.36 DRUG MATRIX
Transporter Transporter Ki 5.70 CHEMBL
Transporter Transporter Ki 6.02 CHEMBL
D(3) dopamine receptor GPCR Ki 7.41 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.92 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.54 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.66 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 9.52 CHEMBL
D(2) dopamine receptor GPCR Ki 7.90 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.40 CHEMBL
Histamine H1 receptor GPCR Ki 8.20 CHEMBL
D(4) dopamine receptor GPCR Ki 7.30 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.60 IUPHAR
Alpha-1A adrenergic receptor GPCR IC50 7.19 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR

External reference:

IDSource
4020996 VUID
N0000148465 NUI
D00454 KEGG_DRUG
221373-18-8 SECONDARY_CAS_RN
4020996 VANDF
C0171021 UMLSCUI
CHEBI:7735 CHEBI
CHEMBL715 ChEMBL_ID
CHEMBL3989694 ChEMBL_ID
CHEMBL1201741 ChEMBL_ID
D000077152 MESH_DESCRIPTOR_UI
DB00334 DRUGBANK_ID
47 IUPHAR_LIGAND_ID
6956 INN_ID
N7U69T4SZR UNII
135398745 PUBCHEM_CID
1294588 RXNORM
169390 MMSL
172501 MMSL
5198 MMSL
6063 MMSL
d04050 MMSL
006204 NDDF
013309 NDDF
108441004 SNOMEDCT_US
386849001 SNOMEDCT_US
725800004 SNOMEDCT_US
735189005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 3 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 6 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3232 CAPSULE 12 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3233 CAPSULE 6 mg ORAL NDA 34 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3234 CAPSULE 12 mg ORAL NDA 34 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 36 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 36 sections
ZYPREXA Zydis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4456 TABLET, ORALLY DISINTEGRATING 20 mg ORAL NDA 36 sections
ZYPREXA Intramuscular HUMAN PRESCRIPTION DRUG LABEL 1 0002-7597 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR NDA 36 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5245 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5246 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5247 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 31 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5248 TABLET, ORALLY DISINTEGRATING 20 mg ORAL ANDA 31 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 3 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 6 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 6 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 12 mg ORAL ANDA 32 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 12 mg ORAL ANDA 32 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5510 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 34 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5511 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 34 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5512 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 34 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5513 TABLET, ORALLY DISINTEGRATING 20 mg ORAL ANDA 34 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0517-0955 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAMUSCULAR ANDA 31 sections