Stem definition | Drug id | CAS RN |
---|---|---|
psychoactive | 1982 | 132539-06-1 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
10 | mg | P |
10 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.69 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 30, 1996 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 1445.70 | 11.35 | 593 | 89251 | 10537 | 50504743 |
Suicide attempt | 1048.04 | 11.35 | 810 | 89034 | 50922 | 50464358 |
Sedation | 892.14 | 11.35 | 598 | 89246 | 30012 | 50485268 |
Intentional overdose | 889.95 | 11.35 | 798 | 89046 | 61706 | 50453574 |
Intentional self-injury | 664.86 | 11.35 | 448 | 89396 | 22664 | 50492616 |
Sopor | 658.76 | 11.35 | 421 | 89423 | 19458 | 50495822 |
Extrapyramidal disorder | 641.05 | 11.35 | 344 | 89500 | 11426 | 50503854 |
Akathisia | 636.86 | 11.35 | 305 | 89539 | 7924 | 50507356 |
Dystonia | 611.79 | 11.35 | 335 | 89509 | 11591 | 50503689 |
Electrocardiogram QT prolonged | 599.16 | 11.35 | 590 | 89254 | 51296 | 50463984 |
Blood prolactin abnormal | 581.70 | 11.35 | 197 | 89647 | 1978 | 50513302 |
Sexual dysfunction | 577.03 | 11.35 | 218 | 89626 | 3074 | 50512206 |
Overdose | 529.10 | 11.35 | 762 | 89082 | 98965 | 50416315 |
Agitation | 520.11 | 11.35 | 554 | 89290 | 52830 | 50462450 |
Anosognosia | 510.86 | 11.35 | 180 | 89664 | 2054 | 50513226 |
Drug interaction | 505.69 | 11.35 | 1102 | 88742 | 198519 | 50316761 |
Psychotic disorder | 486.44 | 11.35 | 362 | 89482 | 21450 | 50493830 |
Toxicity to various agents | 475.78 | 11.35 | 1117 | 88727 | 211382 | 50303898 |
Disturbance in social behaviour | 465.44 | 11.35 | 180 | 89664 | 2714 | 50512566 |
Metabolic disorder | 458.52 | 11.35 | 212 | 89632 | 5074 | 50510206 |
Arthralgia | 452.15 | 11.35 | 112 | 89732 | 438590 | 50076690 |
Hyperprolactinaemia | 439.13 | 11.35 | 180 | 89664 | 3185 | 50512095 |
Schizophrenia | 436.16 | 11.35 | 228 | 89616 | 7169 | 50508111 |
Delusion | 424.24 | 11.35 | 253 | 89591 | 10316 | 50504964 |
Drug abuse | 406.63 | 11.35 | 516 | 89328 | 59330 | 50455950 |
Somnolence | 402.86 | 11.35 | 865 | 88979 | 154120 | 50361160 |
Dyskinesia | 402.56 | 11.35 | 359 | 89485 | 27502 | 50487778 |
Weight increased | 398.17 | 11.35 | 1011 | 88833 | 200880 | 50314400 |
Pain | 397.40 | 11.35 | 272 | 89572 | 578631 | 49936649 |
Post-injection delirium sedation syndrome | 396.86 | 11.35 | 78 | 89766 | 22 | 50515258 |
Hallucination, auditory | 395.05 | 11.35 | 243 | 89601 | 10485 | 50504795 |
Parkinsonism | 376.64 | 11.35 | 220 | 89624 | 8627 | 50506653 |
Catatonia | 359.25 | 11.35 | 161 | 89683 | 3575 | 50511705 |
Completed suicide | 356.37 | 11.35 | 748 | 89096 | 131141 | 50384139 |
Diabetes mellitus | 349.35 | 11.35 | 433 | 89411 | 48600 | 50466680 |
Personality change | 347.17 | 11.35 | 179 | 89665 | 5466 | 50509814 |
Mania | 336.50 | 11.35 | 221 | 89623 | 10695 | 50504585 |
Tardive dyskinesia | 320.44 | 11.35 | 185 | 89659 | 7094 | 50508186 |
Coma | 319.61 | 11.35 | 447 | 89397 | 56432 | 50458848 |
Rheumatoid arthritis | 307.48 | 11.35 | 12 | 89832 | 202538 | 50312742 |
Pleurothotonus | 301.96 | 11.35 | 106 | 89738 | 1195 | 50514085 |
Aggression | 281.29 | 11.35 | 260 | 89584 | 20856 | 50494424 |
Suicidal ideation | 264.32 | 11.35 | 403 | 89441 | 54982 | 50460298 |
Metabolic syndrome | 260.92 | 11.35 | 96 | 89748 | 1251 | 50514029 |
Depressed level of consciousness | 260.70 | 11.35 | 387 | 89457 | 51566 | 50463714 |
Fatigue | 258.14 | 11.35 | 546 | 89298 | 707055 | 49808225 |
Salivary hypersecretion | 257.29 | 11.35 | 155 | 89689 | 6436 | 50508844 |
Hypothermia | 253.57 | 11.35 | 193 | 89651 | 11823 | 50503457 |
Muscle rigidity | 250.66 | 11.35 | 177 | 89667 | 9652 | 50505628 |
Psychomotor hyperactivity | 233.74 | 11.35 | 166 | 89678 | 9135 | 50506145 |
Arthropathy | 230.93 | 11.35 | 12 | 89832 | 157894 | 50357386 |
Restlessness | 230.53 | 11.35 | 253 | 89591 | 24920 | 50490360 |
Hypomania | 229.47 | 11.35 | 126 | 89718 | 4379 | 50510901 |
Joint swelling | 229.28 | 11.35 | 75 | 89769 | 245211 | 50270069 |
Abdominal discomfort | 227.01 | 11.35 | 65 | 89779 | 231576 | 50283704 |
Tachycardia | 225.43 | 11.35 | 527 | 89317 | 99236 | 50416044 |
Blood prolactin increased | 225.05 | 11.35 | 110 | 89734 | 2989 | 50512291 |
Headache | 222.61 | 11.35 | 348 | 89496 | 506187 | 50009093 |
Schizoaffective disorder | 218.29 | 11.35 | 97 | 89747 | 2109 | 50513171 |
Infusion related reaction | 211.78 | 11.35 | 26 | 89818 | 169531 | 50345749 |
Delirium | 211.27 | 11.35 | 298 | 89546 | 37894 | 50477386 |
Rash | 206.31 | 11.35 | 286 | 89558 | 437185 | 50078095 |
Sinusitis | 203.87 | 11.35 | 30 | 89814 | 170528 | 50344752 |
Hallucination | 203.80 | 11.35 | 326 | 89518 | 46331 | 50468949 |
Diarrhoea | 202.80 | 11.35 | 468 | 89376 | 588008 | 49927272 |
Hypersensitivity | 200.67 | 11.35 | 66 | 89778 | 215095 | 50300185 |
Dyspnoea | 199.73 | 11.35 | 422 | 89422 | 547186 | 49968094 |
Swelling | 197.46 | 11.35 | 56 | 89788 | 200816 | 50314464 |
Alopecia | 196.15 | 11.35 | 95 | 89749 | 244952 | 50270328 |
Treatment noncompliance | 195.26 | 11.35 | 254 | 89590 | 29896 | 50485384 |
Contraindicated product administered | 190.59 | 11.35 | 21 | 89823 | 148937 | 50366343 |
Drug hypersensitivity | 185.20 | 11.35 | 108 | 89736 | 250902 | 50264378 |
Gestational diabetes | 184.74 | 11.35 | 132 | 89712 | 7333 | 50507947 |
Abnormal behaviour | 184.22 | 11.35 | 200 | 89644 | 19458 | 50495822 |
Pruritus | 183.73 | 11.35 | 141 | 89703 | 283427 | 50231853 |
Persecutory delusion | 177.16 | 11.35 | 86 | 89758 | 2301 | 50512979 |
Miosis | 175.83 | 11.35 | 120 | 89724 | 6190 | 50509090 |
Peripheral swelling | 175.48 | 11.35 | 73 | 89771 | 205863 | 50309417 |
Confusional state | 161.61 | 11.35 | 706 | 89138 | 185222 | 50330058 |
Oculogyric crisis | 161.11 | 11.35 | 69 | 89775 | 1368 | 50513912 |
Nasopharyngitis | 160.20 | 11.35 | 71 | 89773 | 192856 | 50322424 |
Glossodynia | 159.32 | 11.35 | 12 | 89832 | 115557 | 50399723 |
Social avoidant behaviour | 158.57 | 11.35 | 84 | 89760 | 2713 | 50512567 |
Drug intolerance | 156.37 | 11.35 | 98 | 89746 | 219006 | 50296274 |
Pain in extremity | 155.72 | 11.35 | 153 | 89691 | 272712 | 50242568 |
Systemic lupus erythematosus | 154.26 | 11.35 | 31 | 89813 | 140591 | 50374689 |
Back pain | 149.47 | 11.35 | 104 | 89740 | 219926 | 50295354 |
Paranoia | 146.75 | 11.35 | 132 | 89712 | 10216 | 50505064 |
Camptocormia | 146.22 | 11.35 | 43 | 89801 | 258 | 50515022 |
Blood glucose increased | 144.13 | 11.35 | 361 | 89483 | 70963 | 50444317 |
Tremor | 143.84 | 11.35 | 490 | 89354 | 114413 | 50400867 |
Galactorrhoea | 138.74 | 11.35 | 85 | 89759 | 3638 | 50511642 |
Injection site pain | 136.21 | 11.35 | 18 | 89826 | 111006 | 50404274 |
Blood creatine phosphokinase increased | 135.93 | 11.35 | 199 | 89645 | 26168 | 50489112 |
Psychiatric decompensation | 133.15 | 11.35 | 58 | 89786 | 1200 | 50514080 |
Prescribed overdose | 127.21 | 11.35 | 143 | 89701 | 14457 | 50500823 |
Dysarthria | 126.04 | 11.35 | 233 | 89611 | 37170 | 50478110 |
Drug level increased | 125.79 | 11.35 | 163 | 89681 | 19105 | 50496175 |
Antipsychotic drug level increased | 123.63 | 11.35 | 74 | 89770 | 3035 | 50512245 |
Exposure during pregnancy | 122.71 | 11.35 | 482 | 89362 | 120533 | 50394747 |
Orthostatic hypertension | 120.11 | 11.35 | 39 | 89805 | 339 | 50514941 |
Bradyphrenia | 119.30 | 11.35 | 94 | 89750 | 6058 | 50509222 |
Cough | 117.22 | 11.35 | 154 | 89690 | 241110 | 50274170 |
Psychotic symptom | 115.78 | 11.35 | 52 | 89792 | 1160 | 50514120 |
Pneumonia aspiration | 113.20 | 11.35 | 200 | 89644 | 30804 | 50484476 |
Urticaria | 111.80 | 11.35 | 45 | 89799 | 129516 | 50385764 |
Blood triglycerides increased | 111.09 | 11.35 | 118 | 89726 | 11194 | 50504086 |
Rhabdomyolysis | 107.08 | 11.35 | 223 | 89621 | 38804 | 50476476 |
Neutropenia | 105.09 | 11.35 | 530 | 89314 | 147435 | 50367845 |
Discomfort | 104.97 | 11.35 | 31 | 89813 | 108349 | 50406931 |
Posture abnormal | 102.47 | 11.35 | 57 | 89787 | 2032 | 50513248 |
Nausea | 101.92 | 11.35 | 785 | 89059 | 704613 | 49810667 |
Disorientation | 101.18 | 11.35 | 206 | 89638 | 35278 | 50480002 |
Antipsychotic drug level above therapeutic | 100.80 | 11.35 | 44 | 89800 | 915 | 50514365 |
Therapeutic product effect decreased | 99.57 | 11.35 | 59 | 89785 | 135991 | 50379289 |
Anxiety | 98.57 | 11.35 | 595 | 89249 | 177011 | 50338269 |
Cardio-respiratory arrest | 97.76 | 11.35 | 262 | 89582 | 53630 | 50461650 |
Treatment failure | 97.51 | 11.35 | 62 | 89782 | 137575 | 50377705 |
Arthritis | 97.43 | 11.35 | 18 | 89826 | 86703 | 50428577 |
Jaundice cholestatic | 96.76 | 11.35 | 77 | 89767 | 5034 | 50510246 |
Leukopenia | 96.16 | 11.35 | 301 | 89543 | 67227 | 50448053 |
Obesity | 95.87 | 11.35 | 133 | 89711 | 16642 | 50498638 |
Granulocytopenia | 95.18 | 11.35 | 77 | 89767 | 5154 | 50510126 |
Diabetic coma | 93.27 | 11.35 | 38 | 89806 | 661 | 50514619 |
Pulmonary embolism | 92.68 | 11.35 | 392 | 89452 | 101312 | 50413968 |
Amenorrhoea | 91.39 | 11.35 | 93 | 89751 | 8391 | 50506889 |
Chest discomfort | 90.74 | 11.35 | 26 | 89818 | 92696 | 50422584 |
Psychomotor retardation | 90.51 | 11.35 | 63 | 89781 | 3355 | 50511925 |
Injection site erythema | 89.89 | 11.35 | 13 | 89831 | 74923 | 50440357 |
Psychiatric symptom | 88.98 | 11.35 | 70 | 89774 | 4500 | 50510780 |
Product dose omission issue | 88.58 | 11.35 | 118 | 89726 | 183720 | 50331560 |
Mental disorder | 87.00 | 11.35 | 147 | 89697 | 21844 | 50493436 |
Obsessive-compulsive disorder | 84.81 | 11.35 | 60 | 89784 | 3280 | 50512000 |
Apathy | 83.61 | 11.35 | 84 | 89760 | 7464 | 50507816 |
Generalised tonic-clonic seizure | 82.55 | 11.35 | 159 | 89685 | 26151 | 50489129 |
Insurance issue | 81.97 | 11.35 | 53 | 89791 | 2495 | 50512785 |
Pericarditis | 80.91 | 11.35 | 20 | 89824 | 78669 | 50436611 |
Bipolar disorder | 80.05 | 11.35 | 78 | 89766 | 6679 | 50508601 |
Seizure | 79.32 | 11.35 | 416 | 89428 | 117458 | 50397822 |
Respiratory depression | 77.45 | 11.35 | 101 | 89743 | 11909 | 50503371 |
Impaired healing | 77.29 | 11.35 | 15 | 89829 | 69771 | 50445509 |
Type 2 diabetes mellitus | 76.88 | 11.35 | 181 | 89663 | 34194 | 50481086 |
Mutism | 74.14 | 11.35 | 40 | 89804 | 1341 | 50513939 |
Mental impairment | 74.14 | 11.35 | 99 | 89745 | 11945 | 50503335 |
Infection | 73.57 | 11.35 | 121 | 89723 | 172833 | 50342447 |
Increased appetite | 73.02 | 11.35 | 82 | 89762 | 8279 | 50507001 |
Polydipsia | 72.19 | 11.35 | 53 | 89791 | 3071 | 50512209 |
Osteoarthritis | 71.39 | 11.35 | 17 | 89827 | 68589 | 50446691 |
Stomatitis | 71.29 | 11.35 | 46 | 89798 | 101298 | 50413982 |
Myocarditis | 71.22 | 11.35 | 79 | 89765 | 7868 | 50507412 |
Wound | 69.15 | 11.35 | 52 | 89792 | 105742 | 50409538 |
Product use issue | 68.91 | 11.35 | 99 | 89745 | 149376 | 50365904 |
Loss of consciousness | 68.63 | 11.35 | 366 | 89478 | 103987 | 50411293 |
Hallucinations, mixed | 67.57 | 11.35 | 57 | 89787 | 4046 | 50511234 |
Serotonin syndrome | 67.53 | 11.35 | 141 | 89703 | 24572 | 50490708 |
Thinking abnormal | 67.28 | 11.35 | 84 | 89760 | 9483 | 50505797 |
Dyslipidaemia | 66.99 | 11.35 | 67 | 89777 | 5921 | 50509359 |
Negativism | 66.64 | 11.35 | 25 | 89819 | 345 | 50514935 |
Myalgia | 65.97 | 11.35 | 74 | 89770 | 124245 | 50391035 |
Blister | 65.41 | 11.35 | 35 | 89809 | 85383 | 50429897 |
Obsessive-compulsive symptom | 65.37 | 11.35 | 15 | 89829 | 25 | 50515255 |
Respiratory arrest | 64.93 | 11.35 | 156 | 89688 | 29853 | 50485427 |
Cogwheel rigidity | 62.23 | 11.35 | 39 | 89805 | 1738 | 50513542 |
Sinus tachycardia | 62.09 | 11.35 | 125 | 89719 | 21229 | 50494051 |
Hyponatraemia | 61.73 | 11.35 | 335 | 89509 | 95804 | 50419476 |
Poisoning | 61.45 | 11.35 | 92 | 89752 | 12337 | 50502943 |
Lower respiratory tract infection | 60.68 | 11.35 | 48 | 89796 | 95153 | 50420127 |
Irritability | 59.61 | 11.35 | 146 | 89698 | 28280 | 50487000 |
Injection site pruritus | 59.25 | 11.35 | 3 | 89841 | 40408 | 50474872 |
Obsessive thoughts | 58.91 | 11.35 | 25 | 89819 | 484 | 50514796 |
Screaming | 58.81 | 11.35 | 46 | 89798 | 2932 | 50512348 |
Hyperglycaemia | 58.13 | 11.35 | 169 | 89675 | 36236 | 50479044 |
Altered state of consciousness | 57.54 | 11.35 | 123 | 89721 | 21787 | 50493493 |
Speech disorder | 56.74 | 11.35 | 165 | 89679 | 35383 | 50479897 |
Cardiac arrest | 56.09 | 11.35 | 295 | 89549 | 83356 | 50431924 |
Wheezing | 56.08 | 11.35 | 20 | 89824 | 62027 | 50453253 |
Herpes zoster | 55.69 | 11.35 | 28 | 89816 | 70758 | 50444522 |
Gastrointestinal disorder | 54.88 | 11.35 | 52 | 89792 | 94404 | 50420876 |
Influenza | 54.76 | 11.35 | 47 | 89797 | 89491 | 50425789 |
Psoriatic arthropathy | 54.48 | 11.35 | 9 | 89835 | 47023 | 50468257 |
Mydriasis | 54.46 | 11.35 | 80 | 89764 | 10547 | 50504733 |
Acute psychosis | 54.34 | 11.35 | 39 | 89805 | 2181 | 50513099 |
Unresponsive to stimuli | 53.67 | 11.35 | 147 | 89697 | 30462 | 50484818 |
Substance abuse | 53.39 | 11.35 | 50 | 89794 | 4074 | 50511206 |
Irritable bowel syndrome | 53.02 | 11.35 | 13 | 89831 | 51428 | 50463852 |
Malaise | 52.70 | 11.35 | 364 | 89480 | 335168 | 50180112 |
Mobility decreased | 52.62 | 11.35 | 39 | 89805 | 79909 | 50435371 |
Bone pain | 52.62 | 11.35 | 10 | 89834 | 47219 | 50468061 |
Torsade de pointes | 52.06 | 11.35 | 83 | 89761 | 11752 | 50503528 |
Disturbance in attention | 51.95 | 11.35 | 147 | 89697 | 31039 | 50484241 |
Abdominal pain upper | 51.91 | 11.35 | 130 | 89714 | 159179 | 50356101 |
Hyperthermia | 51.62 | 11.35 | 66 | 89778 | 7630 | 50507650 |
Folliculitis | 51.49 | 11.35 | 5 | 89839 | 39220 | 50476060 |
Anaphylactic reaction | 51.34 | 11.35 | 16 | 89828 | 54039 | 50461241 |
Trimethylaminuria | 51.11 | 11.35 | 16 | 89828 | 122 | 50515158 |
Somatic symptom disorder of pregnancy | 51.01 | 11.35 | 15 | 89829 | 90 | 50515190 |
Hyperammonaemic encephalopathy | 50.96 | 11.35 | 36 | 89808 | 1963 | 50513317 |
Muscle injury | 50.70 | 11.35 | 4 | 89840 | 37107 | 50478173 |
Hypoaesthesia | 50.48 | 11.35 | 93 | 89751 | 127164 | 50388116 |
Neutrophil count decreased | 50.42 | 11.35 | 188 | 89656 | 45838 | 50469442 |
Intentional product use issue | 50.01 | 11.35 | 38 | 89806 | 76880 | 50438400 |
Impulse-control disorder | 49.30 | 11.35 | 24 | 89820 | 646 | 50514634 |
White blood cell count increased | 49.19 | 11.35 | 176 | 89668 | 42064 | 50473216 |
Injection site reaction | 48.99 | 11.35 | 14 | 89830 | 50018 | 50465262 |
Depression | 48.71 | 11.35 | 478 | 89366 | 164945 | 50350335 |
Chest pain | 48.33 | 11.35 | 157 | 89687 | 176725 | 50338555 |
Logorrhoea | 48.30 | 11.35 | 37 | 89807 | 2287 | 50512993 |
Polyuria | 47.66 | 11.35 | 61 | 89783 | 7060 | 50508220 |
Urinary retention | 47.14 | 11.35 | 127 | 89717 | 26063 | 50489217 |
Self esteem decreased | 46.79 | 11.35 | 22 | 89822 | 547 | 50514733 |
Diet refusal | 46.50 | 11.35 | 22 | 89822 | 555 | 50514725 |
Food craving | 46.46 | 11.35 | 30 | 89814 | 1409 | 50513871 |
Hepatocellular injury | 45.88 | 11.35 | 125 | 89719 | 25822 | 50489458 |
Drooling | 45.69 | 11.35 | 42 | 89802 | 3342 | 50511938 |
Neuropathy peripheral | 45.65 | 11.35 | 63 | 89781 | 96694 | 50418586 |
White blood cell count decreased | 45.63 | 11.35 | 359 | 89485 | 116363 | 50398917 |
Stupor | 45.54 | 11.35 | 43 | 89801 | 3540 | 50511740 |
Hypertonia | 45.45 | 11.35 | 45 | 89799 | 3928 | 50511352 |
Osteoporosis | 44.99 | 11.35 | 12 | 89832 | 44867 | 50470413 |
Hyperphagia | 44.74 | 11.35 | 30 | 89814 | 1502 | 50513778 |
Euphoric mood | 44.68 | 11.35 | 45 | 89799 | 4010 | 50511270 |
Neck pain | 44.25 | 11.35 | 23 | 89821 | 57044 | 50458236 |
Sleep disorder due to general medical condition, insomnia type | 44.08 | 11.35 | 3 | 89841 | 31444 | 50483836 |
Musculoskeletal pain | 44.00 | 11.35 | 38 | 89806 | 72139 | 50443141 |
Coma scale abnormal | 43.74 | 11.35 | 48 | 89796 | 4723 | 50510557 |
Flushing | 43.70 | 11.35 | 33 | 89811 | 66982 | 50448298 |
Psoriasis | 43.70 | 11.35 | 35 | 89809 | 68965 | 50446315 |
Sudden death | 43.66 | 11.35 | 66 | 89778 | 8925 | 50506355 |
Knee arthroplasty | 43.49 | 11.35 | 6 | 89838 | 35840 | 50479440 |
Brain stem thrombosis | 42.68 | 11.35 | 8 | 89836 | 0 | 50515280 |
Asthma | 42.32 | 11.35 | 58 | 89786 | 89279 | 50426001 |
Homicide | 42.16 | 11.35 | 18 | 89826 | 354 | 50514926 |
Muscle spasms | 42.03 | 11.35 | 101 | 89743 | 125452 | 50389828 |
Megacolon | 41.82 | 11.35 | 30 | 89814 | 1676 | 50513604 |
Refusal of treatment by patient | 41.49 | 11.35 | 48 | 89796 | 5005 | 50510275 |
Electroencephalogram abnormal | 40.71 | 11.35 | 40 | 89804 | 3459 | 50511821 |
Inappropriate antidiuretic hormone secretion | 40.70 | 11.35 | 79 | 89765 | 13064 | 50502216 |
Nasal congestion | 40.54 | 11.35 | 20 | 89824 | 51100 | 50464180 |
Alanine aminotransferase increased | 40.35 | 11.35 | 282 | 89562 | 88077 | 50427203 |
Injection site swelling | 40.33 | 11.35 | 12 | 89832 | 41761 | 50473519 |
Bradykinesia | 40.26 | 11.35 | 42 | 89802 | 3901 | 50511379 |
Bipolar I disorder | 40.24 | 11.35 | 28 | 89816 | 1490 | 50513790 |
Device expulsion | 39.67 | 11.35 | 3 | 89841 | 28819 | 50486461 |
Contusion | 39.36 | 11.35 | 88 | 89756 | 112095 | 50403185 |
Symptom recurrence | 39.23 | 11.35 | 21 | 89823 | 693 | 50514587 |
Self-injurious ideation | 38.85 | 11.35 | 32 | 89812 | 2197 | 50513083 |
Musculoskeletal stiffness | 38.69 | 11.35 | 109 | 89735 | 128372 | 50386908 |
Cognitive disorder | 38.56 | 11.35 | 168 | 89676 | 43955 | 50471325 |
Inflammation | 38.44 | 11.35 | 27 | 89817 | 56885 | 50458395 |
Osteonecrosis of jaw | 38.18 | 11.35 | 6 | 89838 | 32520 | 50482760 |
Delusion of reference | 38.16 | 11.35 | 12 | 89832 | 93 | 50515187 |
Depressive symptom | 38.02 | 11.35 | 37 | 89807 | 3163 | 50512117 |
Erythema | 37.91 | 11.35 | 133 | 89711 | 146281 | 50368999 |
Maternal exposure during pregnancy | 37.56 | 11.35 | 151 | 89693 | 159627 | 50355653 |
Cor pulmonale acute | 37.50 | 11.35 | 16 | 89828 | 314 | 50514966 |
Hypernatraemia | 37.44 | 11.35 | 51 | 89793 | 6270 | 50509010 |
Embolism venous | 37.36 | 11.35 | 33 | 89811 | 2492 | 50512788 |
Hypokinesia | 37.30 | 11.35 | 73 | 89771 | 12144 | 50503136 |
Epilepsy | 37.24 | 11.35 | 103 | 89741 | 21464 | 50493816 |
Intentional product misuse | 37.14 | 11.35 | 173 | 89671 | 46561 | 50468719 |
Fibromyalgia | 36.58 | 11.35 | 17 | 89827 | 44961 | 50470319 |
Impulsive behaviour | 36.57 | 11.35 | 26 | 89818 | 1432 | 50513848 |
Neutrophil count increased | 36.48 | 11.35 | 79 | 89765 | 14116 | 50501164 |
Oropharyngeal pain | 36.36 | 11.35 | 51 | 89793 | 77750 | 50437530 |
Plasma cell mastitis | 36.10 | 11.35 | 9 | 89835 | 25 | 50515255 |
Illusion | 36 | 11.35 | 22 | 89822 | 937 | 50514343 |
Electrocardiogram T wave inversion | 35.58 | 11.35 | 36 | 89808 | 3225 | 50512055 |
Dyspnoea exertional | 35.01 | 11.35 | 24 | 89820 | 51209 | 50464071 |
Gamma-glutamyltransferase increased | 34.98 | 11.35 | 124 | 89720 | 29499 | 50485781 |
Hip arthroplasty | 34.85 | 11.35 | 6 | 89838 | 30423 | 50484857 |
Depressed mood | 34.81 | 11.35 | 136 | 89708 | 33887 | 50481393 |
Agranulocytosis | 34.73 | 11.35 | 100 | 89744 | 21321 | 50493959 |
Poisoning deliberate | 34.13 | 11.35 | 55 | 89789 | 7857 | 50507423 |
Head banging | 33.99 | 11.35 | 16 | 89828 | 399 | 50514881 |
Myoclonic epilepsy | 33.15 | 11.35 | 21 | 89823 | 954 | 50514326 |
Behaviour disorder | 33.03 | 11.35 | 30 | 89814 | 2350 | 50512930 |
Disease progression | 32.98 | 11.35 | 76 | 89768 | 95790 | 50419490 |
Blunted affect | 32.51 | 11.35 | 13 | 89831 | 215 | 50515065 |
Diabetic ketoacidosis | 32.50 | 11.35 | 87 | 89757 | 17785 | 50497495 |
Menstruation irregular | 32.46 | 11.35 | 47 | 89797 | 6115 | 50509165 |
Waxy flexibility | 32.42 | 11.35 | 11 | 89833 | 111 | 50515169 |
Interstitial lung disease | 32.40 | 11.35 | 28 | 89816 | 53148 | 50462132 |
Multiple sclerosis relapse | 32.31 | 11.35 | 18 | 89826 | 42946 | 50472334 |
Dyspepsia | 32.26 | 11.35 | 51 | 89793 | 74046 | 50441234 |
Flat affect | 32.11 | 11.35 | 23 | 89821 | 1282 | 50513998 |
Refusal of examination | 32.09 | 11.35 | 10 | 89834 | 75 | 50515205 |
Abdominal pain | 31.96 | 11.35 | 267 | 89577 | 235961 | 50279319 |
Chills | 31.40 | 11.35 | 79 | 89765 | 96608 | 50418672 |
Ataxia | 31.26 | 11.35 | 73 | 89771 | 13713 | 50501567 |
Distractibility | 31.22 | 11.35 | 15 | 89829 | 392 | 50514888 |
Circulatory collapse | 31.11 | 11.35 | 92 | 89752 | 19908 | 50495372 |
Asthenia | 31.05 | 11.35 | 390 | 89454 | 318652 | 50196628 |
Respiratory dyskinesia | 30.70 | 11.35 | 8 | 89836 | 28 | 50515252 |
Personality change due to a general medical condition | 30.39 | 11.35 | 10 | 89834 | 91 | 50515189 |
Feeling guilty | 30.28 | 11.35 | 16 | 89828 | 514 | 50514766 |
Oromandibular dystonia | 30.11 | 11.35 | 15 | 89829 | 425 | 50514855 |
Mental status changes | 30.10 | 11.35 | 136 | 89708 | 36136 | 50479144 |
Upper respiratory tract infection | 30.00 | 11.35 | 44 | 89800 | 65854 | 50449426 |
Paraesthesia | 29.94 | 11.35 | 111 | 89733 | 120132 | 50395148 |
Hot flush | 29.77 | 11.35 | 21 | 89823 | 44148 | 50471132 |
Suicidal behaviour | 29.64 | 11.35 | 28 | 89816 | 2306 | 50512974 |
Grandiosity | 29.62 | 11.35 | 13 | 89831 | 274 | 50515006 |
Diabetic hyperosmolar coma | 29.52 | 11.35 | 14 | 89830 | 355 | 50514925 |
Affective disorder | 29.48 | 11.35 | 41 | 89803 | 5140 | 50510140 |
Disinhibition | 28.93 | 11.35 | 18 | 89826 | 792 | 50514488 |
Psychotic disorder due to a general medical condition | 28.78 | 11.35 | 12 | 89832 | 222 | 50515058 |
Coma scale | 28.76 | 11.35 | 8 | 89836 | 38 | 50515242 |
Feeling hot | 28.65 | 11.35 | 17 | 89827 | 39185 | 50476095 |
Throat irritation | 28.62 | 11.35 | 9 | 89835 | 30230 | 50485050 |
Monocyte count decreased | 28.61 | 11.35 | 25 | 89819 | 1861 | 50513419 |
Abnormal clotting factor | 28.54 | 11.35 | 10 | 89834 | 112 | 50515168 |
Basal cell carcinoma | 28.12 | 11.35 | 4 | 89840 | 23352 | 50491928 |
Myoclonus | 27.90 | 11.35 | 72 | 89772 | 14398 | 50500882 |
Pharyngeal dystonia | 27.87 | 11.35 | 6 | 89838 | 6 | 50515274 |
Device dislocation | 27.62 | 11.35 | 3 | 89841 | 21543 | 50493737 |
Influenza like illness | 27.51 | 11.35 | 37 | 89807 | 57422 | 50457858 |
Ill-defined disorder | 27.40 | 11.35 | 34 | 89810 | 54620 | 50460660 |
Sciatica | 27.35 | 11.35 | 3 | 89841 | 21379 | 50493901 |
Weight decreased | 27.30 | 11.35 | 256 | 89588 | 220989 | 50294291 |
Migraine | 27.27 | 11.35 | 58 | 89786 | 75222 | 50440058 |
Blood bilirubin increased | 27.24 | 11.35 | 121 | 89723 | 31917 | 50483363 |
Leukocytosis | 26.22 | 11.35 | 94 | 89750 | 22485 | 50492795 |
Thought blocking | 26.16 | 11.35 | 9 | 89835 | 95 | 50515185 |
Cardiac failure congestive | 25.83 | 11.35 | 71 | 89773 | 84311 | 50430969 |
Negative symptoms in schizophrenia | 25.59 | 11.35 | 9 | 89835 | 102 | 50515178 |
Limb discomfort | 25.40 | 11.35 | 6 | 89838 | 24351 | 50490929 |
Loss of personal independence in daily activities | 25.35 | 11.35 | 54 | 89790 | 69996 | 50445284 |
Water intoxication | 25.32 | 11.35 | 13 | 89831 | 393 | 50514887 |
Bundle branch block right | 25.30 | 11.35 | 36 | 89808 | 4609 | 50510671 |
Burning sensation | 25.26 | 11.35 | 26 | 89818 | 45420 | 50469860 |
Selective eating disorder | 25.24 | 11.35 | 23 | 89821 | 1809 | 50513471 |
Cataract | 25.24 | 11.35 | 28 | 89816 | 47272 | 50468008 |
Device issue | 25.06 | 11.35 | 3 | 89841 | 19969 | 50495311 |
Akinesia | 25.04 | 11.35 | 21 | 89823 | 1478 | 50513802 |
Accidental overdose | 25.01 | 11.35 | 84 | 89760 | 19449 | 50495831 |
Apallic syndrome | 25.00 | 11.35 | 15 | 89829 | 618 | 50514662 |
Rhinorrhoea | 24.92 | 11.35 | 33 | 89811 | 51550 | 50463730 |
Injection site haemorrhage | 24.91 | 11.35 | 4 | 89840 | 21342 | 50493938 |
Skin ulcer | 24.86 | 11.35 | 16 | 89828 | 35302 | 50479978 |
Eosinophil count increased | 24.85 | 11.35 | 51 | 89793 | 8779 | 50506501 |
Brain injury | 24.85 | 11.35 | 41 | 89803 | 5973 | 50509307 |
Sinus rhythm | 24.84 | 11.35 | 15 | 89829 | 625 | 50514655 |
Diverticulitis | 24.81 | 11.35 | 14 | 89830 | 33168 | 50482112 |
Psychomotor skills impaired | 24.77 | 11.35 | 24 | 89820 | 2040 | 50513240 |
Acquired haemophilia | 24.75 | 11.35 | 17 | 89827 | 886 | 50514394 |
Phagophobia | 24.71 | 11.35 | 7 | 89837 | 36 | 50515244 |
Abulia | 24.70 | 11.35 | 13 | 89831 | 414 | 50514866 |
Withdrawal syndrome | 24.64 | 11.35 | 78 | 89766 | 17512 | 50497768 |
Hallucination, visual | 24.59 | 11.35 | 75 | 89769 | 16507 | 50498773 |
Eosinophilia | 24.58 | 11.35 | 81 | 89763 | 18571 | 50496709 |
Impaired self-care | 24.16 | 11.35 | 22 | 89822 | 1729 | 50513551 |
Muscular weakness | 24.12 | 11.35 | 87 | 89757 | 94926 | 50420354 |
Bronchitis | 24.11 | 11.35 | 99 | 89745 | 104060 | 50411220 |
Anaemia | 24.02 | 11.35 | 310 | 89534 | 252146 | 50263134 |
Breast enlargement | 24.01 | 11.35 | 20 | 89824 | 1395 | 50513885 |
Atrial fibrillation | 23.99 | 11.35 | 96 | 89748 | 101649 | 50413631 |
Skin exfoliation | 23.97 | 11.35 | 15 | 89829 | 33597 | 50481683 |
Lethargy | 23.88 | 11.35 | 160 | 89684 | 49272 | 50466008 |
Aspartate aminotransferase increased | 23.71 | 11.35 | 227 | 89617 | 77771 | 50437509 |
Pain in jaw | 23.70 | 11.35 | 20 | 89824 | 38408 | 50476872 |
Tachypnoea | 23.58 | 11.35 | 68 | 89776 | 14509 | 50500771 |
Neuralgia | 23.58 | 11.35 | 5 | 89839 | 21858 | 50493422 |
Abnormal weight gain | 23.56 | 11.35 | 20 | 89824 | 1432 | 50513848 |
Wrong drug | 23.55 | 11.35 | 9 | 89835 | 131 | 50515149 |
Drug ineffective | 23.50 | 11.35 | 1203 | 88641 | 818130 | 49697150 |
COVID-19 | 23.42 | 11.35 | 29 | 89815 | 46633 | 50468647 |
Urinary tract infection | 23.23 | 11.35 | 270 | 89574 | 223750 | 50291530 |
Pancreatitis | 23.09 | 11.35 | 142 | 89702 | 42472 | 50472808 |
Bone disorder | 23.08 | 11.35 | 3 | 89841 | 18749 | 50496531 |
Anaphylactic shock | 23.02 | 11.35 | 4 | 89840 | 20151 | 50495129 |
Electrocardiogram J wave | 22.75 | 11.35 | 5 | 89839 | 6 | 50515274 |
Dissociative disorder | 22.60 | 11.35 | 10 | 89834 | 215 | 50515065 |
Patient dissatisfaction with treatment | 22.52 | 11.35 | 7 | 89837 | 52 | 50515228 |
Ketoacidosis | 22.43 | 11.35 | 31 | 89813 | 3864 | 50511416 |
Ear infection | 22.41 | 11.35 | 9 | 89835 | 25961 | 50489319 |
Meige's syndrome | 22.31 | 11.35 | 5 | 89839 | 7 | 50515273 |
Breast discomfort | 22.28 | 11.35 | 12 | 89832 | 401 | 50514879 |
Neoplasm progression | 22.23 | 11.35 | 12 | 89832 | 29145 | 50486135 |
Major depression | 22.07 | 11.35 | 42 | 89802 | 6842 | 50508438 |
Antiphospholipid antibodies | 22.07 | 11.35 | 9 | 89835 | 157 | 50515123 |
Bursitis | 22.03 | 11.35 | 6 | 89838 | 22129 | 50493151 |
Electrocardiogram J wave abnormal | 21.91 | 11.35 | 5 | 89839 | 8 | 50515272 |
Ideas of reference | 21.90 | 11.35 | 8 | 89836 | 102 | 50515178 |
Autonomic nervous system imbalance | 21.87 | 11.35 | 24 | 89820 | 2361 | 50512919 |
Polydipsia psychogenic | 21.75 | 11.35 | 7 | 89837 | 59 | 50515221 |
Rash pruritic | 21.72 | 11.35 | 32 | 89812 | 47814 | 50467466 |
Unevaluable event | 21.71 | 11.35 | 30 | 89814 | 46036 | 50469244 |
Insulin C-peptide increased | 21.64 | 11.35 | 7 | 89837 | 60 | 50515220 |
Pressure of speech | 21.54 | 11.35 | 13 | 89831 | 541 | 50514739 |
Ileus paralytic | 21.49 | 11.35 | 31 | 89813 | 4019 | 50511261 |
Constricted affect | 21.34 | 11.35 | 4 | 89840 | 0 | 50515280 |
Night sweats | 21.29 | 11.35 | 17 | 89827 | 33557 | 50481723 |
Haemoglobin urine | 21.22 | 11.35 | 8 | 89836 | 112 | 50515168 |
Differential white blood cell count abnormal | 21.17 | 11.35 | 14 | 89830 | 685 | 50514595 |
Palpitations | 21.14 | 11.35 | 91 | 89753 | 94415 | 50420865 |
Pleural effusion | 21.06 | 11.35 | 74 | 89770 | 81380 | 50433900 |
Retinal coloboma | 21.00 | 11.35 | 6 | 89838 | 32 | 50515248 |
Haematochezia | 20.85 | 11.35 | 24 | 89820 | 39858 | 50475422 |
Pulmonary mass | 20.75 | 11.35 | 4 | 89840 | 18701 | 50496579 |
Bezoar | 20.71 | 11.35 | 18 | 89826 | 1330 | 50513950 |
Hypotonia | 20.59 | 11.35 | 45 | 89799 | 8089 | 50507191 |
Ventricular dyskinesia | 20.48 | 11.35 | 8 | 89836 | 124 | 50515156 |
Hyperthermia malignant | 20.46 | 11.35 | 14 | 89830 | 725 | 50514555 |
Joint range of motion decreased | 20.45 | 11.35 | 4 | 89840 | 18508 | 50496772 |
Productive cough | 20.45 | 11.35 | 39 | 89805 | 52655 | 50462625 |
Hepatitis toxic | 20.24 | 11.35 | 25 | 89819 | 2791 | 50512489 |
Drug monitoring procedure incorrectly performed | 20.19 | 11.35 | 8 | 89836 | 129 | 50515151 |
Femur fracture | 20.18 | 11.35 | 22 | 89822 | 37442 | 50477838 |
Throat tightness | 20.10 | 11.35 | 6 | 89838 | 20841 | 50494439 |
Compulsions | 19.95 | 11.35 | 9 | 89835 | 203 | 50515077 |
Hypoxic-ischaemic encephalopathy | 19.80 | 11.35 | 29 | 89815 | 3813 | 50511467 |
Psychogenic visual disorder | 19.77 | 11.35 | 5 | 89839 | 15 | 50515265 |
Encephalitis autoimmune | 19.74 | 11.35 | 17 | 89827 | 1241 | 50514039 |
Iris coloboma | 19.74 | 11.35 | 6 | 89838 | 41 | 50515239 |
Insomnia | 19.64 | 11.35 | 427 | 89417 | 174438 | 50340842 |
Cytomegalovirus infection | 19.59 | 11.35 | 4 | 89840 | 17958 | 50497322 |
Somnambulism | 19.58 | 11.35 | 33 | 89811 | 4891 | 50510389 |
Gastrointestinal sounds abnormal | 19.55 | 11.35 | 28 | 89816 | 3606 | 50511674 |
Hyporesponsive to stimuli | 19.44 | 11.35 | 15 | 89829 | 937 | 50514343 |
Hypoventilation | 19.35 | 11.35 | 29 | 89815 | 3892 | 50511388 |
Respiratory tract infection | 19.33 | 11.35 | 17 | 89827 | 32000 | 50483280 |
Staring | 19.33 | 11.35 | 18 | 89826 | 1456 | 50513824 |
Hallucination, olfactory | 19.32 | 11.35 | 9 | 89835 | 219 | 50515061 |
Long QT syndrome | 19.20 | 11.35 | 25 | 89819 | 2942 | 50512338 |
Electrocardiogram abnormal | 19.17 | 11.35 | 42 | 89802 | 7563 | 50507717 |
Feelings of worthlessness | 19.07 | 11.35 | 10 | 89834 | 316 | 50514964 |
Mucosal inflammation | 19.06 | 11.35 | 26 | 89818 | 40116 | 50475164 |
Skin discolouration | 19.06 | 11.35 | 18 | 89826 | 32739 | 50482541 |
Stress | 19.02 | 11.35 | 42 | 89802 | 53751 | 50461529 |
Tubo-ovarian abscess | 19.02 | 11.35 | 10 | 89834 | 318 | 50514962 |
Cholelithiasis | 19.00 | 11.35 | 124 | 89720 | 37849 | 50477431 |
Product packaging confusion | 18.99 | 11.35 | 8 | 89836 | 152 | 50515128 |
Caesarean section | 18.92 | 11.35 | 66 | 89778 | 15573 | 50499707 |
Hepatotoxicity | 18.91 | 11.35 | 97 | 89747 | 27129 | 50488151 |
Suspiciousness | 18.90 | 11.35 | 10 | 89834 | 322 | 50514958 |
Maternal exposure during breast feeding | 18.89 | 11.35 | 26 | 89818 | 3228 | 50512052 |
Parkinsonian gait | 18.83 | 11.35 | 11 | 89833 | 431 | 50514849 |
Hypotonia neonatal | 18.83 | 11.35 | 15 | 89829 | 982 | 50514298 |
Kidney infection | 18.81 | 11.35 | 5 | 89839 | 18741 | 50496539 |
Localised infection | 18.70 | 11.35 | 11 | 89833 | 25474 | 50489806 |
Blood pressure increased | 18.65 | 11.35 | 149 | 89695 | 132983 | 50382297 |
Insulin resistance | 18.63 | 11.35 | 13 | 89831 | 695 | 50514585 |
Thrombosis | 18.60 | 11.35 | 45 | 89799 | 55788 | 50459492 |
Condition aggravated | 18.59 | 11.35 | 673 | 89171 | 296385 | 50218895 |
Personality disorder | 18.57 | 11.35 | 30 | 89814 | 4294 | 50510986 |
Asphyxia | 18.51 | 11.35 | 34 | 89810 | 5393 | 50509887 |
Central obesity | 18.50 | 11.35 | 15 | 89829 | 1007 | 50514273 |
Hepatic cytolysis | 18.47 | 11.35 | 43 | 89801 | 8060 | 50507220 |
Rebound psychosis | 18.47 | 11.35 | 5 | 89839 | 21 | 50515259 |
Overweight | 18.43 | 11.35 | 25 | 89819 | 3061 | 50512219 |
Joint stiffness | 18.41 | 11.35 | 16 | 89828 | 30292 | 50484988 |
Hypercapnia | 18.39 | 11.35 | 31 | 89813 | 4596 | 50510684 |
Fluid retention | 18.36 | 11.35 | 39 | 89805 | 50610 | 50464670 |
Surgery | 18.28 | 11.35 | 16 | 89828 | 30189 | 50485091 |
Genitourinary symptom | 18.10 | 11.35 | 6 | 89838 | 56 | 50515224 |
Nephrolithiasis | 18.01 | 11.35 | 21 | 89823 | 34672 | 50480608 |
Death | 18.00 | 11.35 | 440 | 89404 | 324939 | 50190341 |
Nuchal rigidity | 17.96 | 11.35 | 12 | 89832 | 597 | 50514683 |
Echolalia | 17.96 | 11.35 | 8 | 89836 | 175 | 50515105 |
Disease recurrence | 17.95 | 11.35 | 77 | 89767 | 20004 | 50495276 |
Eosinophil count decreased | 17.94 | 11.35 | 18 | 89826 | 1597 | 50513683 |
Taciturnity | 17.69 | 11.35 | 4 | 89840 | 6 | 50515274 |
Dysphoria | 17.68 | 11.35 | 31 | 89813 | 4743 | 50510537 |
Neonatal respiratory depression | 17.64 | 11.35 | 6 | 89838 | 61 | 50515219 |
Delusional disorder, unspecified type | 17.61 | 11.35 | 10 | 89834 | 371 | 50514909 |
Stereotypy | 17.59 | 11.35 | 10 | 89834 | 372 | 50514908 |
Suspected suicide | 17.57 | 11.35 | 33 | 89811 | 5324 | 50509956 |
Self-medication | 17.48 | 11.35 | 21 | 89823 | 2278 | 50513002 |
Gastric disorder | 17.47 | 11.35 | 16 | 89828 | 29532 | 50485748 |
Myocardial reperfusion injury | 17.44 | 11.35 | 5 | 89839 | 27 | 50515253 |
Delusional disorder, erotomanic type | 17.44 | 11.35 | 5 | 89839 | 27 | 50515253 |
Hypercholesterolaemia | 17.41 | 11.35 | 53 | 89791 | 11650 | 50503630 |
Toxic leukoencephalopathy | 17.37 | 11.35 | 12 | 89832 | 631 | 50514649 |
Hypophagia | 17.36 | 11.35 | 96 | 89748 | 27632 | 50487648 |
Areflexia | 17.34 | 11.35 | 23 | 89821 | 2757 | 50512523 |
Foot fracture | 17.28 | 11.35 | 7 | 89837 | 20084 | 50495196 |
Cellulitis | 17.20 | 11.35 | 66 | 89778 | 70732 | 50444548 |
Drug withdrawal syndrome | 17.17 | 11.35 | 89 | 89755 | 24992 | 50490288 |
Cyclothymic disorder | 17.14 | 11.35 | 6 | 89838 | 67 | 50515213 |
Hypersomnia | 17.14 | 11.35 | 63 | 89781 | 15251 | 50500029 |
Myocardial hypoxia | 16.96 | 11.35 | 4 | 89840 | 8 | 50515272 |
Ketosis-prone diabetes mellitus | 16.96 | 11.35 | 4 | 89840 | 8 | 50515272 |
Extensor plantar response | 16.91 | 11.35 | 15 | 89829 | 1139 | 50514141 |
Glutamate dehydrogenase increased | 16.86 | 11.35 | 5 | 89839 | 31 | 50515249 |
Malignant catatonia | 16.86 | 11.35 | 7 | 89837 | 128 | 50515152 |
Torticollis | 16.85 | 11.35 | 18 | 89826 | 1718 | 50513562 |
Immunodeficiency | 16.81 | 11.35 | 3 | 89841 | 14825 | 50500455 |
Fungal infection | 16.81 | 11.35 | 17 | 89827 | 29948 | 50485332 |
Type 1 diabetes mellitus | 16.77 | 11.35 | 24 | 89820 | 3089 | 50512191 |
Sinus disorder | 16.59 | 11.35 | 6 | 89838 | 18452 | 50496828 |
Seasonal allergy | 16.57 | 11.35 | 3 | 89841 | 14673 | 50500607 |
Incontinence | 16.56 | 11.35 | 47 | 89797 | 9938 | 50505342 |
Brief psychotic disorder, with postpartum onset | 16.47 | 11.35 | 5 | 89839 | 34 | 50515246 |
Cystitis | 16.41 | 11.35 | 34 | 89810 | 44530 | 50470750 |
Echopraxia | 16.35 | 11.35 | 4 | 89840 | 10 | 50515270 |
Morose | 16.22 | 11.35 | 5 | 89839 | 36 | 50515244 |
Opisthotonus | 16.20 | 11.35 | 9 | 89835 | 320 | 50514960 |
Therapy partial responder | 16.16 | 11.35 | 36 | 89808 | 6555 | 50508725 |
Newborn persistent pulmonary hypertension | 16.15 | 11.35 | 7 | 89837 | 143 | 50515137 |
Osteonecrosis | 16.12 | 11.35 | 10 | 89834 | 22507 | 50492773 |
Decreased gait velocity | 16.08 | 11.35 | 4 | 89840 | 11 | 50515269 |
Grunting | 16.05 | 11.35 | 8 | 89836 | 227 | 50515053 |
Muscle twitching | 16.04 | 11.35 | 62 | 89782 | 15369 | 50499911 |
Excessive masturbation | 16.01 | 11.35 | 3 | 89841 | 0 | 50515280 |
Intermittent explosive disorder | 16.01 | 11.35 | 3 | 89841 | 0 | 50515280 |
Neurosyphilis | 16.01 | 11.35 | 3 | 89841 | 0 | 50515280 |
Inborn error of metabolism | 16.01 | 11.35 | 3 | 89841 | 0 | 50515280 |
Microphthalmos | 15.97 | 11.35 | 7 | 89837 | 147 | 50515133 |
Atonic urinary bladder | 15.91 | 11.35 | 6 | 89838 | 84 | 50515196 |
Full blood count decreased | 15.90 | 11.35 | 10 | 89834 | 22336 | 50492944 |
Transient aphasia | 15.87 | 11.35 | 5 | 89839 | 39 | 50515241 |
Flight of ideas | 15.87 | 11.35 | 9 | 89835 | 333 | 50514947 |
Dysgeusia | 15.81 | 11.35 | 28 | 89816 | 38888 | 50476392 |
Haemorrhoids | 15.80 | 11.35 | 7 | 89837 | 19046 | 50496234 |
Tendonitis | 15.76 | 11.35 | 5 | 89839 | 16700 | 50498580 |
Electrocardiogram QT interval abnormal | 15.76 | 11.35 | 7 | 89837 | 152 | 50515128 |
Single umbilical artery | 15.70 | 11.35 | 8 | 89836 | 238 | 50515042 |
Large for dates baby | 15.57 | 11.35 | 10 | 89834 | 465 | 50514815 |
Sluggishness | 15.50 | 11.35 | 28 | 89816 | 4385 | 50510895 |
Skin disorder | 15.45 | 11.35 | 12 | 89832 | 24018 | 50491262 |
CSF glucose increased | 15.45 | 11.35 | 5 | 89839 | 43 | 50515237 |
International normalised ratio abnormal | 15.44 | 11.35 | 22 | 89822 | 2821 | 50512459 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 15.42 | 11.35 | 11 | 89833 | 609 | 50514671 |
High density lipoprotein decreased | 15.41 | 11.35 | 17 | 89827 | 1683 | 50513597 |
Homicidal ideation | 15.39 | 11.35 | 17 | 89827 | 1685 | 50513595 |
Drug level above therapeutic | 15.23 | 11.35 | 26 | 89818 | 3894 | 50511386 |
Helplessness | 15.22 | 11.35 | 8 | 89836 | 254 | 50515026 |
Accidental death | 15.05 | 11.35 | 17 | 89827 | 1727 | 50513553 |
Blood alkaline phosphatase increased | 14.96 | 11.35 | 116 | 89728 | 37410 | 50477870 |
Lipids abnormal | 14.89 | 11.35 | 8 | 89836 | 266 | 50515014 |
Suspected suicide attempt | 14.85 | 11.35 | 6 | 89838 | 102 | 50515178 |
Ear pain | 14.81 | 11.35 | 17 | 89827 | 28266 | 50487014 |
Upper gastrointestinal haemorrhage | 14.78 | 11.35 | 5 | 89839 | 16030 | 50499250 |
Product use in unapproved indication | 14.69 | 11.35 | 288 | 89556 | 115531 | 50399749 |
Cerebral atrophy | 14.66 | 11.35 | 28 | 89816 | 4573 | 50510707 |
Product quality issue | 14.64 | 11.35 | 20 | 89824 | 30838 | 50484442 |
Rash macular | 14.60 | 11.35 | 8 | 89836 | 19269 | 50496011 |
Communication disorder | 14.55 | 11.35 | 19 | 89825 | 2242 | 50513038 |
Toxic encephalopathy | 14.52 | 11.35 | 31 | 89813 | 5484 | 50509796 |
Soliloquy | 14.50 | 11.35 | 7 | 89837 | 185 | 50515095 |
Accelerated hypertension | 14.48 | 11.35 | 9 | 89835 | 395 | 50514885 |
Ulcer | 14.43 | 11.35 | 9 | 89835 | 20191 | 50495089 |
Pneumonia | 14.41 | 11.35 | 538 | 89306 | 377863 | 50137417 |
Amaurosis | 14.41 | 11.35 | 10 | 89834 | 530 | 50514750 |
Affective ambivalence | 14.38 | 11.35 | 4 | 89840 | 19 | 50515261 |
Oral candidiasis | 14.37 | 11.35 | 6 | 89838 | 16909 | 50498371 |
Body mass index increased | 14.37 | 11.35 | 13 | 89831 | 1013 | 50514267 |
Metastases to bone | 14.32 | 11.35 | 7 | 89837 | 17988 | 50497292 |
Metastases to liver | 14.30 | 11.35 | 9 | 89835 | 20095 | 50495185 |
Slow response to stimuli | 14.16 | 11.35 | 12 | 89832 | 857 | 50514423 |
Hypertransaminasaemia | 14.09 | 11.35 | 24 | 89820 | 3587 | 50511693 |
Foetal exposure during pregnancy | 14.09 | 11.35 | 90 | 89754 | 27269 | 50488011 |
Hyperlipidaemia | 14.08 | 11.35 | 65 | 89779 | 17425 | 50497855 |
Urinary incontinence | 14.04 | 11.35 | 92 | 89752 | 28116 | 50487164 |
Gastrointestinal lymphoma | 14.04 | 11.35 | 5 | 89839 | 59 | 50515221 |
Compulsive sexual behaviour | 14.04 | 11.35 | 5 | 89839 | 59 | 50515221 |
Joint effusion | 13.99 | 11.35 | 3 | 89841 | 13018 | 50502262 |
Brief psychotic disorder with marked stressors | 13.96 | 11.35 | 5 | 89839 | 60 | 50515220 |
Facial wasting | 13.93 | 11.35 | 3 | 89841 | 3 | 50515277 |
Pelvic sepsis | 13.93 | 11.35 | 3 | 89841 | 3 | 50515277 |
Dyskinesia neonatal | 13.93 | 11.35 | 3 | 89841 | 3 | 50515277 |
Onychogryphosis | 13.93 | 11.35 | 3 | 89841 | 3 | 50515277 |
Asocial behaviour | 13.89 | 11.35 | 4 | 89840 | 22 | 50515258 |
Enuresis | 13.87 | 11.35 | 18 | 89826 | 2111 | 50513169 |
Alcohol abuse | 13.86 | 11.35 | 17 | 89827 | 1884 | 50513396 |
Malignant neoplasm progression | 13.81 | 11.35 | 68 | 89776 | 68056 | 50447224 |
Skin striae | 13.74 | 11.35 | 13 | 89831 | 1073 | 50514207 |
Muscle tone disorder | 13.74 | 11.35 | 6 | 89838 | 125 | 50515155 |
Muscle contractions involuntary | 13.71 | 11.35 | 17 | 89827 | 1905 | 50513375 |
Slow speech | 13.71 | 11.35 | 14 | 89830 | 1268 | 50514012 |
Glucocorticoids increased | 13.69 | 11.35 | 6 | 89838 | 126 | 50515154 |
Illness | 13.68 | 11.35 | 14 | 89830 | 24526 | 50490754 |
Sneezing | 13.62 | 11.35 | 4 | 89840 | 14040 | 50501240 |
Hepatic function abnormal | 13.58 | 11.35 | 102 | 89742 | 32579 | 50482701 |
Blood urea decreased | 13.53 | 11.35 | 18 | 89826 | 2164 | 50513116 |
Blood pressure fluctuation | 13.47 | 11.35 | 27 | 89817 | 35796 | 50479484 |
Myelodysplastic syndrome | 13.46 | 11.35 | 5 | 89839 | 15127 | 50500153 |
Gastrooesophageal reflux disease | 13.44 | 11.35 | 80 | 89764 | 76348 | 50438932 |
Acute myeloid leukaemia | 13.38 | 11.35 | 5 | 89839 | 15069 | 50500211 |
Haematocrit increased | 13.35 | 11.35 | 17 | 89827 | 1957 | 50513323 |
Neuroglycopenia | 13.33 | 11.35 | 5 | 89839 | 69 | 50515211 |
Chronic kidney disease | 13.29 | 11.35 | 32 | 89812 | 39739 | 50475541 |
Metamyelocyte count increased | 13.27 | 11.35 | 7 | 89837 | 224 | 50515056 |
Moaning | 13.26 | 11.35 | 11 | 89833 | 763 | 50514517 |
Alcohol use | 13.21 | 11.35 | 17 | 89827 | 1978 | 50513302 |
Coagulation factor VII level decreased | 13.20 | 11.35 | 5 | 89839 | 71 | 50515209 |
Chorea | 13.19 | 11.35 | 14 | 89830 | 1326 | 50513954 |
Fear | 13.17 | 11.35 | 56 | 89788 | 14493 | 50500787 |
Oral pain | 13.16 | 11.35 | 15 | 89829 | 25018 | 50490262 |
Pituitary tumour benign | 13.11 | 11.35 | 16 | 89828 | 1765 | 50513515 |
Hospitalisation | 13.10 | 11.35 | 181 | 89663 | 67756 | 50447524 |
Glassy eyes | 13.01 | 11.35 | 5 | 89839 | 74 | 50515206 |
Crying | 12.99 | 11.35 | 71 | 89773 | 20345 | 50494935 |
Palmar-plantar erythrodysaesthesia syndrome | 12.97 | 11.35 | 10 | 89834 | 20088 | 50495192 |
Ventricular arrhythmia | 12.92 | 11.35 | 22 | 89822 | 3287 | 50511993 |
Mean cell haemoglobin decreased | 12.86 | 11.35 | 22 | 89822 | 3301 | 50511979 |
Inappropriate affect | 12.86 | 11.35 | 11 | 89833 | 796 | 50514484 |
Reduced facial expression | 12.85 | 11.35 | 15 | 89829 | 1579 | 50513701 |
Blood glucose | 12.84 | 11.35 | 4 | 89840 | 30 | 50515250 |
Lip swelling | 12.81 | 11.35 | 15 | 89829 | 24721 | 50490559 |
Gastrointestinal haemorrhage | 12.76 | 11.35 | 77 | 89767 | 73244 | 50442036 |
Dry skin | 12.73 | 11.35 | 37 | 89807 | 43154 | 50472126 |
Hypersomnia-bulimia syndrome | 12.72 | 11.35 | 3 | 89841 | 6 | 50515274 |
Alveolar capillary dysplasia | 12.72 | 11.35 | 3 | 89841 | 6 | 50515274 |
Hyperinsulinism | 12.72 | 11.35 | 3 | 89841 | 6 | 50515274 |
Ovarian germ cell cancer stage II | 12.72 | 11.35 | 4 | 89840 | 31 | 50515249 |
Anterograde amnesia | 12.70 | 11.35 | 9 | 89835 | 493 | 50514787 |
Drug withdrawal syndrome neonatal | 12.68 | 11.35 | 16 | 89828 | 1825 | 50513455 |
Drug abuser | 12.67 | 11.35 | 20 | 89824 | 2808 | 50512472 |
Alcoholism | 12.65 | 11.35 | 15 | 89829 | 1605 | 50513675 |
Deafness | 12.65 | 11.35 | 6 | 89838 | 15685 | 50499595 |
Dysbiosis | 12.61 | 11.35 | 10 | 89834 | 650 | 50514630 |
Grip strength decreased | 12.61 | 11.35 | 3 | 89841 | 12118 | 50503162 |
Incoherent | 12.58 | 11.35 | 25 | 89819 | 4205 | 50511075 |
Device related infection | 12.53 | 11.35 | 11 | 89833 | 20724 | 50494556 |
Red blood cells urine | 12.53 | 11.35 | 9 | 89835 | 504 | 50514776 |
Terminal insomnia | 12.49 | 11.35 | 10 | 89834 | 659 | 50514621 |
Tic | 12.49 | 11.35 | 13 | 89831 | 1204 | 50514076 |
Heart rate decreased | 12.49 | 11.35 | 29 | 89815 | 36468 | 50478812 |
Mouth ulceration | 12.47 | 11.35 | 19 | 89825 | 28005 | 50487275 |
Pulmonary fibrosis | 12.46 | 11.35 | 15 | 89829 | 24422 | 50490858 |
Dysphonia | 12.45 | 11.35 | 32 | 89812 | 38860 | 50476420 |
Platelet count increased | 12.42 | 11.35 | 55 | 89789 | 14485 | 50500795 |
Pupillary reflex impaired | 12.41 | 11.35 | 16 | 89828 | 1865 | 50513415 |
Pseudobulbar palsy | 12.41 | 11.35 | 3 | 89841 | 7 | 50515273 |
Consciousness fluctuating | 12.36 | 11.35 | 10 | 89834 | 669 | 50514611 |
Tachyphrenia | 12.24 | 11.35 | 13 | 89831 | 1232 | 50514048 |
Anger | 12.16 | 11.35 | 46 | 89798 | 11287 | 50503993 |
Thirst | 12.07 | 11.35 | 44 | 89800 | 10606 | 50504674 |
Wrong patient received product | 12.07 | 11.35 | 15 | 89829 | 1685 | 50513595 |
Drug resistance | 12.06 | 11.35 | 66 | 89778 | 18923 | 50496357 |
Hyponatraemic syndrome | 12.05 | 11.35 | 9 | 89835 | 535 | 50514745 |
Hypomagnesaemia | 12.03 | 11.35 | 14 | 89830 | 23142 | 50492138 |
Immune-mediated encephalitis | 12.02 | 11.35 | 5 | 89839 | 92 | 50515188 |
Epileptic psychosis | 12.00 | 11.35 | 4 | 89840 | 38 | 50515242 |
Limb injury | 11.93 | 11.35 | 11 | 89833 | 20239 | 50495041 |
Female sexual dysfunction | 11.91 | 11.35 | 4 | 89840 | 39 | 50515241 |
Thought insertion | 11.86 | 11.35 | 3 | 89841 | 9 | 50515271 |
Analgesic drug level increased | 11.85 | 11.35 | 15 | 89829 | 1716 | 50513564 |
Delusional disorder, persecutory type | 11.85 | 11.35 | 6 | 89838 | 176 | 50515104 |
Myoglobin blood increased | 11.84 | 11.35 | 13 | 89831 | 1280 | 50514000 |
Prolactin-producing pituitary tumour | 11.82 | 11.35 | 5 | 89839 | 96 | 50515184 |
Antipsychotic drug level below therapeutic | 11.72 | 11.35 | 7 | 89837 | 286 | 50514994 |
Diabetic neuropathy | 11.63 | 11.35 | 22 | 89822 | 3569 | 50511711 |
Procedural pain | 11.60 | 11.35 | 5 | 89839 | 13827 | 50501453 |
Osteopenia | 11.59 | 11.35 | 8 | 89836 | 17010 | 50498270 |
Premature delivery | 11.57 | 11.35 | 15 | 89829 | 23648 | 50491632 |
Hyperinsulinaemia | 11.54 | 11.35 | 5 | 89839 | 102 | 50515178 |
Tongue biting | 11.54 | 11.35 | 13 | 89831 | 1317 | 50513963 |
Pseudomembranous colitis | 11.52 | 11.35 | 19 | 89825 | 2766 | 50512514 |
Joint injury | 11.51 | 11.35 | 13 | 89831 | 21776 | 50493504 |
Right ventricular failure | 11.46 | 11.35 | 7 | 89837 | 15886 | 50499394 |
Drug use disorder | 11.44 | 11.35 | 20 | 89824 | 3052 | 50512228 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 1681.52 | 12.12 | 885 | 94071 | 15263 | 29464308 |
Sedation | 1029.81 | 12.12 | 661 | 94295 | 16744 | 29462827 |
Post-injection delirium sedation syndrome | 1024.69 | 12.12 | 247 | 94709 | 203 | 29479368 |
Psychotic disorder | 764 | 12.12 | 585 | 94371 | 19769 | 29459802 |
Agitation | 637.49 | 12.12 | 804 | 94152 | 50500 | 29429071 |
Weight increased | 629.92 | 12.12 | 985 | 93971 | 75682 | 29403889 |
Overdose | 602.98 | 12.12 | 987 | 93969 | 78832 | 29400739 |
Akathisia | 577.55 | 12.12 | 325 | 94631 | 6417 | 29473154 |
Suicide attempt | 557.07 | 12.12 | 615 | 94341 | 33495 | 29446076 |
Schizophrenia | 555.69 | 12.12 | 314 | 94642 | 6251 | 29473320 |
Extrapyramidal disorder | 547.38 | 12.12 | 373 | 94583 | 10458 | 29469113 |
Aggression | 522.90 | 12.12 | 607 | 94349 | 34934 | 29444637 |
Intentional self-injury | 471.47 | 12.12 | 360 | 94596 | 12101 | 29467470 |
Delusion | 457.59 | 12.12 | 339 | 94617 | 10877 | 29468694 |
Hallucination, auditory | 441.64 | 12.12 | 312 | 94644 | 9281 | 29470290 |
Sopor | 402.93 | 12.12 | 311 | 94645 | 10623 | 29468948 |
Catatonia | 376.20 | 12.12 | 213 | 94743 | 4255 | 29475316 |
Blood creatine phosphokinase increased | 352.62 | 12.12 | 536 | 94420 | 40108 | 29439463 |
Parkinsonism | 340.31 | 12.12 | 239 | 94717 | 7039 | 29472532 |
Mania | 340.31 | 12.12 | 256 | 94700 | 8407 | 29471164 |
Prescribed overdose | 333.14 | 12.12 | 253 | 94703 | 8430 | 29471141 |
Dystonia | 328.38 | 12.12 | 263 | 94693 | 9486 | 29470085 |
Somnolence | 321.37 | 12.12 | 838 | 94118 | 93117 | 29386454 |
Intentional overdose | 318.62 | 12.12 | 497 | 94459 | 38031 | 29441540 |
Diarrhoea | 311.72 | 12.12 | 367 | 94589 | 332331 | 29147240 |
Muscle rigidity | 298.22 | 12.12 | 245 | 94711 | 9166 | 29470405 |
Toxicity to various agents | 293.59 | 12.12 | 1218 | 93738 | 172443 | 29307128 |
Diabetes mellitus | 286.07 | 12.12 | 482 | 94474 | 39349 | 29440222 |
Myocarditis | 283.57 | 12.12 | 254 | 94702 | 10702 | 29468869 |
Electrocardiogram QT prolonged | 276.56 | 12.12 | 450 | 94506 | 35687 | 29443884 |
Arthralgia | 264.41 | 12.12 | 62 | 94894 | 139555 | 29340016 |
Tachycardia | 260.00 | 12.12 | 658 | 94298 | 71752 | 29407819 |
Tardive dyskinesia | 251.26 | 12.12 | 175 | 94781 | 5083 | 29474488 |
Dysarthria | 248.93 | 12.12 | 394 | 94562 | 30517 | 29449054 |
Psychotic symptom | 248.42 | 12.12 | 111 | 94845 | 1303 | 29478268 |
Completed suicide | 247.49 | 12.12 | 743 | 94213 | 89503 | 29390068 |
Salivary hypersecretion | 243.41 | 12.12 | 197 | 94759 | 7212 | 29472359 |
Delirium | 241.79 | 12.12 | 445 | 94511 | 38952 | 29440619 |
Mental impairment | 230.80 | 12.12 | 209 | 94747 | 8932 | 29470639 |
Blood triglycerides increased | 227.84 | 12.12 | 242 | 94714 | 12592 | 29466979 |
Restlessness | 225.28 | 12.12 | 315 | 94641 | 21830 | 29457741 |
Abnormal behaviour | 222.04 | 12.12 | 320 | 94636 | 22807 | 29456764 |
Hyperprolactinaemia | 220.90 | 12.12 | 99 | 94857 | 1171 | 29478400 |
Oculogyric crisis | 220.60 | 12.12 | 101 | 94855 | 1260 | 29478311 |
Priapism | 218.26 | 12.12 | 151 | 94805 | 4337 | 29475234 |
Type 2 diabetes mellitus | 218.26 | 12.12 | 243 | 94713 | 13338 | 29466233 |
Blood prolactin abnormal | 209.09 | 12.12 | 85 | 94871 | 775 | 29478796 |
Dyspnoea | 208.36 | 12.12 | 464 | 94492 | 326268 | 29153303 |
Metabolic syndrome | 197.79 | 12.12 | 96 | 94860 | 1377 | 29478194 |
Suicidal ideation | 189.36 | 12.12 | 373 | 94583 | 34343 | 29445228 |
Rash | 187.50 | 12.12 | 200 | 94756 | 189619 | 29289952 |
Depressed level of consciousness | 182.58 | 12.12 | 381 | 94575 | 36561 | 29443010 |
Increased appetite | 181.98 | 12.12 | 153 | 94803 | 5911 | 29473660 |
Coma | 177.89 | 12.12 | 392 | 94564 | 39058 | 29440513 |
Treatment noncompliance | 174.94 | 12.12 | 294 | 94662 | 23933 | 29455638 |
Paranoia | 174.88 | 12.12 | 186 | 94770 | 9691 | 29469880 |
Fatigue | 173.75 | 12.12 | 486 | 94470 | 316335 | 29163236 |
Pain | 172.21 | 12.12 | 178 | 94778 | 171254 | 29308317 |
Anosognosia | 169.05 | 12.12 | 72 | 94884 | 746 | 29478825 |
Dyskinesia | 167.42 | 12.12 | 260 | 94696 | 19801 | 29459770 |
Hypothermia | 165.37 | 12.12 | 175 | 94781 | 9064 | 29470507 |
Diabetic ketoacidosis | 164.00 | 12.12 | 229 | 94727 | 15844 | 29463727 |
Disinhibition | 163.95 | 12.12 | 103 | 94853 | 2504 | 29477067 |
Nausea | 162.05 | 12.12 | 439 | 94517 | 288816 | 29190755 |
Blood prolactin increased | 159.22 | 12.12 | 84 | 94872 | 1450 | 29478121 |
Anaemia | 159.00 | 12.12 | 250 | 94706 | 200701 | 29278870 |
Pruritus | 151.49 | 12.12 | 94 | 94862 | 116755 | 29362816 |
Sexual dysfunction | 150.84 | 12.12 | 135 | 94821 | 5679 | 29473892 |
Antipsychotic drug level below therapeutic | 147.26 | 12.12 | 87 | 94869 | 1887 | 29477684 |
Confusional state | 144.35 | 12.12 | 799 | 94157 | 127078 | 29352493 |
Metabolic disorder | 140.24 | 12.12 | 107 | 94849 | 3588 | 29475983 |
Malignant neoplasm progression | 137.32 | 12.12 | 34 | 94922 | 73825 | 29405746 |
Disorientation | 136.11 | 12.12 | 296 | 94660 | 29219 | 29450352 |
Emotional poverty | 133.70 | 12.12 | 52 | 94904 | 417 | 29479154 |
Obsessive-compulsive disorder | 132.27 | 12.12 | 113 | 94843 | 4463 | 29475108 |
Pneumonia | 132.08 | 12.12 | 555 | 94401 | 319617 | 29159954 |
Serotonin syndrome | 131.07 | 12.12 | 216 | 94740 | 17296 | 29462275 |
Polydipsia | 130.76 | 12.12 | 100 | 94856 | 3365 | 29476206 |
Obesity | 129.32 | 12.12 | 159 | 94797 | 9704 | 29469867 |
Disturbance in social behaviour | 126.93 | 12.12 | 75 | 94881 | 1627 | 29477944 |
Cough | 123.34 | 12.12 | 135 | 94821 | 126592 | 29352979 |
Euphoric mood | 121.16 | 12.12 | 110 | 94846 | 4715 | 29474856 |
Diabetic coma | 120.53 | 12.12 | 56 | 94900 | 724 | 29478847 |
Blood cholesterol increased | 120.29 | 12.12 | 195 | 94761 | 15400 | 29464171 |
Psychomotor hyperactivity | 120.16 | 12.12 | 140 | 94816 | 8073 | 29471498 |
Pain in extremity | 117.32 | 12.12 | 109 | 94847 | 110324 | 29369247 |
Death | 116.55 | 12.12 | 635 | 94321 | 341449 | 29138122 |
Acute kidney injury | 116.11 | 12.12 | 449 | 94507 | 264818 | 29214753 |
Schizoaffective disorder | 113.91 | 12.12 | 60 | 94896 | 1032 | 29478539 |
Thinking abnormal | 113.48 | 12.12 | 110 | 94846 | 5126 | 29474445 |
Rhabdomyolysis | 113.08 | 12.12 | 440 | 94516 | 60368 | 29419203 |
Cardiac failure congestive | 111.75 | 12.12 | 53 | 94903 | 76528 | 29403043 |
Speech disorder | 109.74 | 12.12 | 237 | 94719 | 23279 | 29456292 |
Tremor | 109.38 | 12.12 | 497 | 94459 | 73041 | 29406530 |
Disease progression | 107.36 | 12.12 | 65 | 94891 | 81851 | 29397720 |
Drug interaction | 105.30 | 12.12 | 1031 | 93925 | 196354 | 29283217 |
Negativism | 104.86 | 12.12 | 41 | 94915 | 334 | 29479237 |
Granulocytopenia | 104.55 | 12.12 | 112 | 94844 | 5882 | 29473689 |
Dyslipidaemia | 103.52 | 12.12 | 112 | 94844 | 5949 | 29473622 |
Atrial fibrillation | 103.37 | 12.12 | 112 | 94844 | 105534 | 29374037 |
Irritability | 100.80 | 12.12 | 221 | 94735 | 21931 | 29457640 |
Psychiatric decompensation | 98.56 | 12.12 | 61 | 94895 | 1443 | 29478128 |
Urticaria | 94.40 | 12.12 | 29 | 94927 | 54631 | 29424940 |
Gastrointestinal haemorrhage | 93.66 | 12.12 | 71 | 94885 | 79462 | 29400109 |
Mental disorder | 93.65 | 12.12 | 157 | 94799 | 12748 | 29466823 |
Interstitial lung disease | 92.10 | 12.12 | 35 | 94921 | 57683 | 29421888 |
Therapeutic product effect variable | 90.90 | 12.12 | 63 | 94893 | 1814 | 29477757 |
Anxiety | 90.65 | 12.12 | 525 | 94431 | 84840 | 29394731 |
Miosis | 90.61 | 12.12 | 120 | 94836 | 7889 | 29471682 |
Leukopenia | 88.80 | 12.12 | 382 | 94574 | 54821 | 29424750 |
Headache | 88.48 | 12.12 | 276 | 94680 | 173731 | 29305840 |
Back pain | 87.83 | 12.12 | 120 | 94836 | 102164 | 29377407 |
Type 1 diabetes mellitus | 87.45 | 12.12 | 81 | 94875 | 3563 | 29476008 |
Joint swelling | 86.31 | 12.12 | 26 | 94930 | 49604 | 29429967 |
Rheumatoid arthritis | 86.28 | 12.12 | 4 | 94952 | 32148 | 29447423 |
Infusion related reaction | 85.95 | 12.12 | 18 | 94938 | 43868 | 29435703 |
Pneumonia aspiration | 85.41 | 12.12 | 286 | 94670 | 36451 | 29443120 |
Febrile neutropenia | 84.53 | 12.12 | 144 | 94812 | 112096 | 29367475 |
Antipsychotic drug level above therapeutic | 83.37 | 12.12 | 49 | 94907 | 1052 | 29478519 |
Delusional disorder, persecutory type | 82.83 | 12.12 | 31 | 94925 | 221 | 29479350 |
Decreased appetite | 81.55 | 12.12 | 220 | 94736 | 145122 | 29334449 |
Hepatic steatosis | 79.53 | 12.12 | 159 | 94797 | 14787 | 29464784 |
Renal impairment | 77.58 | 12.12 | 88 | 94868 | 81245 | 29398326 |
Persecutory delusion | 76.88 | 12.12 | 60 | 94896 | 2081 | 29477490 |
Anticholinergic syndrome | 76.27 | 12.12 | 43 | 94913 | 851 | 29478720 |
Bradykinesia | 75.80 | 12.12 | 73 | 94883 | 3374 | 29476197 |
Neuropathy peripheral | 75.51 | 12.12 | 70 | 94886 | 70957 | 29408614 |
Apathy | 75.33 | 12.12 | 96 | 94860 | 6075 | 29473496 |
Peripheral swelling | 74.90 | 12.12 | 57 | 94899 | 63682 | 29415889 |
Dyspnoea exertional | 73.47 | 12.12 | 14 | 94942 | 36476 | 29443095 |
White blood cell count increased | 73.42 | 12.12 | 276 | 94680 | 37240 | 29442331 |
Oedema peripheral | 72.46 | 12.12 | 139 | 94817 | 103418 | 29376153 |
Sinus tachycardia | 70.44 | 12.12 | 152 | 94804 | 14917 | 29464654 |
Hypomania | 69.67 | 12.12 | 57 | 94899 | 2118 | 29477453 |
Drug abuse | 69.58 | 12.12 | 467 | 94489 | 79416 | 29400155 |
Renal failure | 69.18 | 12.12 | 176 | 94780 | 118423 | 29361148 |
Bradyphrenia | 68.71 | 12.12 | 76 | 94880 | 4138 | 29475433 |
Antipsychotic drug level increased | 68.16 | 12.12 | 67 | 94889 | 3176 | 29476395 |
Social avoidant behaviour | 67.91 | 12.12 | 64 | 94892 | 2878 | 29476693 |
Erythema | 67.64 | 12.12 | 86 | 94870 | 75520 | 29404051 |
Neutrophil count increased | 66.97 | 12.12 | 147 | 94809 | 14595 | 29464976 |
Bipolar disorder | 65.43 | 12.12 | 66 | 94890 | 3229 | 29476342 |
Pleurothotonus | 65.24 | 12.12 | 41 | 94915 | 997 | 29478574 |
Eosinophilic myocarditis | 65.17 | 12.12 | 31 | 94925 | 424 | 29479147 |
Abdominal pain | 63.71 | 12.12 | 222 | 94734 | 135135 | 29344436 |
Drug hypersensitivity | 63.09 | 12.12 | 76 | 94880 | 68330 | 29411241 |
Drooling | 62.73 | 12.12 | 62 | 94894 | 2959 | 29476612 |
Heat stroke | 62.45 | 12.12 | 38 | 94918 | 871 | 29478700 |
Herpes zoster | 61.64 | 12.12 | 11 | 94945 | 30041 | 29449530 |
Hallucination | 61.15 | 12.12 | 295 | 94661 | 44417 | 29435154 |
Tension | 61.00 | 12.12 | 50 | 94906 | 1863 | 29477708 |
Blepharospasm | 59.69 | 12.12 | 39 | 94917 | 1016 | 29478555 |
Psoriasis | 59.55 | 12.12 | 15 | 94941 | 32212 | 29447359 |
Haemorrhage | 58.69 | 12.12 | 36 | 94920 | 45036 | 29434535 |
International normalised ratio increased | 58.40 | 12.12 | 35 | 94921 | 44337 | 29435234 |
Loss of consciousness | 58.05 | 12.12 | 422 | 94534 | 73634 | 29405937 |
Infection | 57.26 | 12.12 | 99 | 94857 | 76652 | 29402919 |
Influenza | 56.59 | 12.12 | 32 | 94924 | 41849 | 29437722 |
Withdrawal syndrome | 56.17 | 12.12 | 115 | 94841 | 10877 | 29468694 |
Obsessive thoughts | 56.01 | 12.12 | 31 | 94925 | 591 | 29478980 |
Agranulocytosis | 55.16 | 12.12 | 167 | 94789 | 20173 | 29459398 |
Delusion of grandeur | 54.84 | 12.12 | 27 | 94929 | 400 | 29479171 |
Psychiatric symptom | 54.66 | 12.12 | 59 | 94897 | 3125 | 29476446 |
Asthenia | 53.69 | 12.12 | 438 | 94518 | 214812 | 29264759 |
Spasmodic dysphonia | 53.52 | 12.12 | 17 | 94939 | 68 | 29479503 |
Visceral congestion | 53.24 | 12.12 | 28 | 94928 | 480 | 29479091 |
Nasopharyngitis | 53.22 | 12.12 | 68 | 94888 | 59597 | 29419974 |
Water intoxication | 52.94 | 12.12 | 26 | 94930 | 383 | 29479188 |
Weight decreased | 52.86 | 12.12 | 277 | 94679 | 150628 | 29328943 |
Stomatitis | 52.12 | 12.12 | 27 | 94929 | 37086 | 29442485 |
Respiratory depression | 51.69 | 12.12 | 126 | 94830 | 13397 | 29466174 |
Melaena | 51.25 | 12.12 | 18 | 94938 | 31158 | 29448413 |
Thrombosis | 51.20 | 12.12 | 38 | 94918 | 43007 | 29436564 |
Sepsis | 51.05 | 12.12 | 260 | 94696 | 142422 | 29337149 |
Plasma cell myeloma | 50.66 | 12.12 | 28 | 94928 | 37087 | 29442484 |
Self-injurious ideation | 50.42 | 12.12 | 41 | 94915 | 1510 | 29478061 |
Hypertriglyceridaemia | 50.36 | 12.12 | 88 | 94868 | 7387 | 29472184 |
Product dose omission issue | 50.24 | 12.12 | 151 | 94805 | 96232 | 29383339 |
Septic shock | 50.12 | 12.12 | 77 | 94879 | 62483 | 29417088 |
Cerebrovascular accident | 49.73 | 12.12 | 108 | 94848 | 76803 | 29402768 |
Feeling guilty | 49.52 | 12.12 | 23 | 94933 | 297 | 29479274 |
Sudden death | 49.25 | 12.12 | 127 | 94829 | 13983 | 29465588 |
Hallucination, visual | 49.20 | 12.12 | 132 | 94824 | 14883 | 29464688 |
General physical health deterioration | 48.84 | 12.12 | 168 | 94788 | 102689 | 29376882 |
Hyperammonaemia | 48.07 | 12.12 | 74 | 94882 | 5589 | 29473982 |
Hyperkalaemia | 47.81 | 12.12 | 77 | 94879 | 61315 | 29418256 |
Obsessive-compulsive symptom | 47.50 | 12.12 | 16 | 94940 | 80 | 29479491 |
Coma scale abnormal | 47.21 | 12.12 | 57 | 94899 | 3412 | 29476159 |
Prostate cancer | 46.93 | 12.12 | 12 | 94944 | 25515 | 29454056 |
Hyperglycaemia | 46.71 | 12.12 | 226 | 94730 | 34061 | 29445510 |
Refusal of treatment by patient | 46.56 | 12.12 | 66 | 94890 | 4628 | 29474943 |
Rebound psychosis | 46.53 | 12.12 | 18 | 94938 | 142 | 29479429 |
Arthropathy | 46.19 | 12.12 | 7 | 94949 | 21547 | 29458024 |
Cognitive disorder | 46.06 | 12.12 | 173 | 94783 | 23326 | 29456245 |
Unresponsive to stimuli | 45.99 | 12.12 | 181 | 94775 | 24945 | 29454626 |
Cardiomyopathy | 45.47 | 12.12 | 127 | 94829 | 14660 | 29464911 |
Insomnia | 45.39 | 12.12 | 460 | 94496 | 88301 | 29391270 |
Ascites | 45.29 | 12.12 | 31 | 94925 | 36588 | 29442983 |
Depressive symptom | 44.79 | 12.12 | 40 | 94916 | 1677 | 29477894 |
Cytomegalovirus infection | 44.47 | 12.12 | 10 | 94946 | 23205 | 29456366 |
Mutism | 44.26 | 12.12 | 28 | 94928 | 689 | 29478882 |
COVID-19 | 43.86 | 12.12 | 31 | 94925 | 35983 | 29443588 |
Musculoskeletal pain | 43.82 | 12.12 | 19 | 94937 | 28934 | 29450637 |
Grandiosity | 43.27 | 12.12 | 21 | 94935 | 301 | 29479270 |
Pancreatitis necrotising | 42.96 | 12.12 | 45 | 94911 | 2302 | 29477269 |
Delusion of replacement | 42.88 | 12.12 | 16 | 94940 | 113 | 29479458 |
Cogwheel rigidity | 42.84 | 12.12 | 34 | 94922 | 1209 | 29478362 |
Intentional product use issue | 42.70 | 12.12 | 44 | 94912 | 42454 | 29437117 |
Pleural effusion | 42.44 | 12.12 | 106 | 94850 | 71802 | 29407769 |
Abdominal discomfort | 42.30 | 12.12 | 55 | 94901 | 47848 | 29431723 |
Derealisation | 41.83 | 12.12 | 25 | 94931 | 554 | 29479017 |
Mucosal inflammation | 41.46 | 12.12 | 25 | 94931 | 31570 | 29448001 |
Chills | 41.39 | 12.12 | 106 | 94850 | 71194 | 29408377 |
Acute myocardial infarction | 41.36 | 12.12 | 57 | 94899 | 48381 | 29431190 |
Sinusitis | 41.27 | 12.12 | 30 | 94926 | 34320 | 29445251 |
Suspiciousness | 41.19 | 12.12 | 20 | 94936 | 287 | 29479284 |
Chronic kidney disease | 40.96 | 12.12 | 34 | 94922 | 36382 | 29443189 |
Cardiac failure | 40.75 | 12.12 | 125 | 94831 | 79162 | 29400409 |
Injection site pain | 40.75 | 12.12 | 27 | 94929 | 32419 | 29447152 |
Haemoglobin decreased | 40.75 | 12.12 | 194 | 94762 | 108181 | 29371390 |
Stupor | 40.51 | 12.12 | 47 | 94909 | 2697 | 29476874 |
Asthma | 40.10 | 12.12 | 30 | 94926 | 33819 | 29445752 |
Blood glucose increased | 40.00 | 12.12 | 325 | 94631 | 58659 | 29420912 |
Drug ineffective | 39.93 | 12.12 | 1482 | 93474 | 361688 | 29117883 |
Personality change | 39.92 | 12.12 | 61 | 94895 | 4577 | 29474994 |
Gout | 39.88 | 12.12 | 4 | 94952 | 16907 | 29462664 |
Blood creatinine increased | 39.72 | 12.12 | 140 | 94816 | 84962 | 29394609 |
Diverticulitis | 39.70 | 12.12 | 5 | 94951 | 17699 | 29461872 |
Haematuria | 39.67 | 12.12 | 50 | 94906 | 44089 | 29435482 |
Hanging | 39.60 | 12.12 | 15 | 94941 | 111 | 29479460 |
Angina pectoris | 39.49 | 12.12 | 20 | 94936 | 27830 | 29451741 |
Xanthoma | 39.45 | 12.12 | 14 | 94942 | 84 | 29479487 |
Poisoning deliberate | 39.30 | 12.12 | 68 | 94888 | 5663 | 29473908 |
Psychomotor retardation | 39.04 | 12.12 | 48 | 94908 | 2928 | 29476643 |
Product substitution issue | 38.90 | 12.12 | 89 | 94867 | 9083 | 29470488 |
Anaphylactic reaction | 38.80 | 12.12 | 20 | 94936 | 27553 | 29452018 |
Altered state of consciousness | 38.63 | 12.12 | 146 | 94810 | 19743 | 29459828 |
Logorrhoea | 38.58 | 12.12 | 42 | 94914 | 2246 | 29477325 |
Arthritis | 38.53 | 12.12 | 16 | 94940 | 25003 | 29454568 |
Hyperreflexia | 38.47 | 12.12 | 46 | 94910 | 2726 | 29476845 |
Eye movement disorder | 38.19 | 12.12 | 53 | 94903 | 3643 | 29475928 |
Erectile dysfunction | 38.17 | 12.12 | 136 | 94820 | 17873 | 29461698 |
Overweight | 38.10 | 12.12 | 34 | 94922 | 1424 | 29478147 |
Inappropriate affect | 38.00 | 12.12 | 23 | 94933 | 522 | 29479049 |
Productive cough | 37.94 | 12.12 | 27 | 94929 | 31232 | 29448339 |
Pulmonary embolism | 37.86 | 12.12 | 394 | 94562 | 76140 | 29403431 |
Hyperlipidaemia | 37.60 | 12.12 | 107 | 94849 | 12483 | 29467088 |
Breast engorgement | 37.55 | 12.12 | 9 | 94947 | 7 | 29479564 |
Pneumonitis | 37.06 | 12.12 | 22 | 94934 | 28022 | 29451549 |
Eosinophil count decreased | 36.94 | 12.12 | 30 | 94926 | 1103 | 29478468 |
Hypervolaemia | 36.91 | 12.12 | 6 | 94950 | 17539 | 29462032 |
Nephrolithiasis | 36.21 | 12.12 | 18 | 94938 | 25316 | 29454255 |
Myocardial infarction | 36.10 | 12.12 | 207 | 94749 | 110089 | 29369482 |
Staphylococcal infection | 35.83 | 12.12 | 25 | 94931 | 29215 | 29450356 |
Disturbance in attention | 35.77 | 12.12 | 150 | 94806 | 21274 | 29458297 |
Diabetic hyperosmolar coma | 35.40 | 12.12 | 19 | 94937 | 340 | 29479231 |
Colitis | 35.36 | 12.12 | 29 | 94927 | 31219 | 29448352 |
Hypersensitivity | 35.26 | 12.12 | 73 | 94883 | 52830 | 29426741 |
Aspiration | 34.88 | 12.12 | 91 | 94865 | 10089 | 29469482 |
Coronary artery disease | 34.80 | 12.12 | 55 | 94901 | 44135 | 29435436 |
Hyponatraemia | 34.79 | 12.12 | 351 | 94605 | 67282 | 29412289 |
Enuresis | 34.70 | 12.12 | 38 | 94918 | 2046 | 29477525 |
Flat affect | 34.69 | 12.12 | 25 | 94931 | 767 | 29478804 |
Troponin increased | 34.50 | 12.12 | 85 | 94871 | 9098 | 29470473 |
Faecaloma | 34.39 | 12.12 | 54 | 94902 | 4148 | 29475423 |
Food craving | 34.10 | 12.12 | 18 | 94938 | 311 | 29479260 |
Eosinophil count increased | 34.05 | 12.12 | 74 | 94882 | 7295 | 29472276 |
Muscle spasms | 33.87 | 12.12 | 102 | 94854 | 64980 | 29414591 |
Wheezing | 33.86 | 12.12 | 34 | 94922 | 33206 | 29446365 |
Sedation complication | 33.71 | 12.12 | 30 | 94926 | 1252 | 29478319 |
Cold-stimulus headache | 33.21 | 12.12 | 7 | 94949 | 0 | 29479571 |
Muscular weakness | 33.20 | 12.12 | 96 | 94860 | 61956 | 29417615 |
Haematochezia | 33.12 | 12.12 | 42 | 94914 | 36941 | 29442630 |
Neutrophil count decreased | 32.82 | 12.12 | 246 | 94710 | 43321 | 29436250 |
Multiple organ dysfunction syndrome | 32.79 | 12.12 | 99 | 94857 | 63017 | 29416554 |
Generalised tonic-clonic seizure | 32.73 | 12.12 | 135 | 94821 | 19004 | 29460567 |
Candida infection | 32.49 | 12.12 | 5 | 94951 | 15220 | 29464351 |
Full blood count decreased | 32.48 | 12.12 | 6 | 94950 | 15986 | 29463585 |
Pancytopenia | 32.36 | 12.12 | 147 | 94809 | 83021 | 29396550 |
Antisocial behaviour | 32.29 | 12.12 | 17 | 94939 | 292 | 29479279 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 32.10 | 12.12 | 27 | 94929 | 1043 | 29478528 |
Oral discharge | 32.03 | 12.12 | 13 | 94943 | 118 | 29479453 |
Wrong patient received product | 31.88 | 12.12 | 38 | 94918 | 2244 | 29477327 |
Fluid retention | 31.82 | 12.12 | 18 | 94938 | 23542 | 29456029 |
Physical assault | 31.80 | 12.12 | 27 | 94929 | 1057 | 29478514 |
Impulsive behaviour | 31.60 | 12.12 | 35 | 94921 | 1908 | 29477663 |
Megacolon | 31.59 | 12.12 | 32 | 94924 | 1573 | 29477998 |
Torticollis | 31.56 | 12.12 | 27 | 94929 | 1068 | 29478503 |
Hallucinations, mixed | 31.53 | 12.12 | 39 | 94917 | 2394 | 29477177 |
Ketoacidosis | 31.51 | 12.12 | 48 | 94908 | 3591 | 29475980 |
Mydriasis | 31.49 | 12.12 | 64 | 94892 | 6021 | 29473550 |
Epistaxis | 31.46 | 12.12 | 75 | 94881 | 51629 | 29427942 |
Asphyxia | 31.26 | 12.12 | 59 | 94897 | 5256 | 29474315 |
Delusional disorder, unspecified type | 31.10 | 12.12 | 22 | 94934 | 655 | 29478916 |
Colitis ischaemic | 31.03 | 12.12 | 62 | 94894 | 5761 | 29473810 |
Skin exfoliation | 31.02 | 12.12 | 17 | 94939 | 22628 | 29456943 |
Angioedema | 30.99 | 12.12 | 34 | 94922 | 31881 | 29447690 |
Poisoning | 30.89 | 12.12 | 86 | 94870 | 9907 | 29469664 |
Bronchitis | 30.86 | 12.12 | 44 | 94912 | 36824 | 29442747 |
Mental status changes | 30.85 | 12.12 | 205 | 94751 | 34722 | 29444849 |
Autonomic nervous system imbalance | 30.65 | 12.12 | 38 | 94918 | 2338 | 29477233 |
Selective eating disorder | 30.64 | 12.12 | 32 | 94924 | 1631 | 29477940 |
Swelling | 30.64 | 12.12 | 41 | 94915 | 35242 | 29444329 |
Hyperphagia | 30.60 | 12.12 | 28 | 94928 | 1212 | 29478359 |
Encephalitis toxic | 30.59 | 12.12 | 16 | 94940 | 271 | 29479300 |
Long QT syndrome | 30.56 | 12.12 | 37 | 94919 | 2221 | 29477350 |
Peptostreptococcus infection | 30.56 | 12.12 | 9 | 94947 | 26 | 29479545 |
Osteoarthritis | 30.54 | 12.12 | 10 | 94946 | 18093 | 29461478 |
Hunger | 30.48 | 12.12 | 29 | 94927 | 1320 | 29478251 |
Neoplasm progression | 30.15 | 12.12 | 11 | 94945 | 18601 | 29460970 |
Posture abnormal | 29.84 | 12.12 | 34 | 94922 | 1913 | 29477658 |
Brain injury | 29.75 | 12.12 | 59 | 94897 | 5453 | 29474118 |
Myelodysplastic syndrome | 29.72 | 12.12 | 10 | 94946 | 17784 | 29461787 |
Affective disorder | 29.61 | 12.12 | 43 | 94913 | 3083 | 29476488 |
Urinary incontinence | 29.57 | 12.12 | 118 | 94838 | 16363 | 29463208 |
Multiple drug therapy | 29.55 | 12.12 | 17 | 94939 | 350 | 29479221 |
Prostatic specific antigen increased | 29.55 | 12.12 | 3 | 94953 | 12561 | 29467010 |
Hyperbilirubinaemia | 29.49 | 12.12 | 6 | 94950 | 14928 | 29464643 |
Hypercholesterolaemia | 29.34 | 12.12 | 69 | 94887 | 7169 | 29472402 |
Thrombocytopenia | 29.30 | 12.12 | 284 | 94672 | 134539 | 29345032 |
Urinary tract infection | 29.28 | 12.12 | 126 | 94830 | 72228 | 29407343 |
White blood cell count decreased | 29.27 | 12.12 | 402 | 94554 | 82960 | 29396611 |
Bipolar I disorder | 29.21 | 12.12 | 22 | 94934 | 723 | 29478848 |
Judgement impaired | 28.97 | 12.12 | 20 | 94936 | 572 | 29478999 |
Inappropriate antidiuretic hormone secretion | 28.92 | 12.12 | 89 | 94867 | 10843 | 29468728 |
Restless legs syndrome | 28.77 | 12.12 | 67 | 94889 | 6917 | 29472654 |
Unevaluable event | 28.76 | 12.12 | 32 | 94924 | 29819 | 29449752 |
Withdrawal catatonia | 28.63 | 12.12 | 11 | 94945 | 85 | 29479486 |
Pressure of speech | 28.56 | 12.12 | 18 | 94938 | 440 | 29479131 |
Paradoxical embolism | 28.47 | 12.12 | 6 | 94950 | 0 | 29479571 |
Hypertonia | 28.33 | 12.12 | 47 | 94909 | 3782 | 29475789 |
Haematoma | 28.24 | 12.12 | 20 | 94936 | 23192 | 29456379 |
Staring | 28.07 | 12.12 | 28 | 94928 | 1351 | 29478220 |
Somatic symptom disorder | 28.07 | 12.12 | 19 | 94937 | 526 | 29479045 |
Chest discomfort | 27.74 | 12.12 | 67 | 94889 | 45916 | 29433655 |
Hyperhidrosis | 27.66 | 12.12 | 323 | 94633 | 64217 | 29415354 |
Cerebrovascular stenosis | 27.57 | 12.12 | 11 | 94945 | 95 | 29479476 |
Protrusion tongue | 27.38 | 12.12 | 13 | 94943 | 177 | 29479394 |
Pulmonary fibrosis | 27.37 | 12.12 | 8 | 94948 | 15574 | 29463997 |
Dysphagia | 27.26 | 12.12 | 283 | 94673 | 54643 | 29424928 |
Neutropenia | 27.21 | 12.12 | 583 | 94373 | 131128 | 29348443 |
Dyspepsia | 27.20 | 12.12 | 34 | 94922 | 30091 | 29449480 |
Waxy flexibility | 26.99 | 12.12 | 11 | 94945 | 101 | 29479470 |
Dysgeusia | 26.98 | 12.12 | 20 | 94936 | 22654 | 29456917 |
Myalgia | 26.93 | 12.12 | 134 | 94822 | 73885 | 29405686 |
Drug withdrawal syndrome neonatal | 26.92 | 12.12 | 43 | 94913 | 3352 | 29476219 |
Perseveration | 26.80 | 12.12 | 11 | 94945 | 103 | 29479468 |
Respiratory arrest | 26.79 | 12.12 | 158 | 94798 | 25675 | 29453896 |
Blunted affect | 26.60 | 12.12 | 15 | 94941 | 297 | 29479274 |
Tumour lysis syndrome | 26.55 | 12.12 | 6 | 94950 | 13878 | 29465693 |
Alanine aminotransferase increased | 26.50 | 12.12 | 346 | 94610 | 70598 | 29408973 |
Osteonecrosis of jaw | 26.34 | 12.12 | 10 | 94946 | 16500 | 29463071 |
Ataxia | 26.16 | 12.12 | 92 | 94864 | 12011 | 29467560 |
Dehydration | 26.08 | 12.12 | 239 | 94717 | 114509 | 29365062 |
Incoherent | 26.05 | 12.12 | 47 | 94909 | 4045 | 29475526 |
Camptocormia | 25.84 | 12.12 | 12 | 94944 | 155 | 29479416 |
Leukocytosis | 25.72 | 12.12 | 135 | 94821 | 21007 | 29458564 |
Urinary retention | 25.67 | 12.12 | 183 | 94773 | 31715 | 29447856 |
Rhinorrhoea | 25.58 | 12.12 | 19 | 94937 | 21500 | 29458071 |
Illness anxiety disorder | 25.56 | 12.12 | 12 | 94944 | 159 | 29479412 |
Psychotic behaviour | 25.48 | 12.12 | 19 | 94937 | 615 | 29478956 |
Dysphonia | 25.45 | 12.12 | 15 | 94941 | 19181 | 29460390 |
Rebound effect | 25.43 | 12.12 | 32 | 94924 | 1999 | 29477572 |
Dementia with Lewy bodies | 25.37 | 12.12 | 19 | 94937 | 619 | 29478952 |
Myoclonus | 25.27 | 12.12 | 97 | 94859 | 13212 | 29466359 |
Metastases to liver | 25.06 | 12.12 | 4 | 94952 | 11852 | 29467719 |
Malignant catatonia | 24.97 | 12.12 | 13 | 94943 | 218 | 29479353 |
Electroencephalogram abnormal | 24.90 | 12.12 | 34 | 94922 | 2301 | 29477270 |
Agitated depression | 24.81 | 12.12 | 13 | 94943 | 221 | 29479350 |
Aspartate aminotransferase increased | 24.75 | 12.12 | 297 | 94659 | 59428 | 29420143 |
Hepatitis C virus test positive | 24.48 | 12.12 | 14 | 94942 | 285 | 29479286 |
Chronic obstructive pulmonary disease | 24.45 | 12.12 | 60 | 94896 | 40895 | 29438676 |
Oedema | 24.41 | 12.12 | 59 | 94897 | 40424 | 29439147 |
Bronchopulmonary aspergillosis | 24.29 | 12.12 | 5 | 94951 | 12339 | 29467232 |
Depressed mood | 24.28 | 12.12 | 111 | 94845 | 16337 | 29463234 |
Hospitalisation | 24.28 | 12.12 | 240 | 94716 | 45748 | 29433823 |
Pulmonary mass | 24.19 | 12.12 | 3 | 94953 | 10745 | 29468826 |
Impaired self-care | 24.19 | 12.12 | 22 | 94934 | 945 | 29478626 |
Cerebellar syndrome | 24.06 | 12.12 | 31 | 94925 | 1983 | 29477588 |
Myelosuppression | 23.96 | 12.12 | 5 | 94951 | 12222 | 29467349 |
Rash pruritic | 23.79 | 12.12 | 22 | 94934 | 22341 | 29457230 |
Exhibitionism | 23.75 | 12.12 | 8 | 94948 | 40 | 29479531 |
Resting tremor | 23.70 | 12.12 | 18 | 94938 | 599 | 29478972 |
Ileus paralytic | 23.62 | 12.12 | 52 | 94904 | 5171 | 29474400 |
Upper respiratory tract infection | 23.53 | 12.12 | 32 | 94924 | 27317 | 29452254 |
Skin ulcer | 23.22 | 12.12 | 16 | 94940 | 18824 | 29460747 |
Choreoathetosis | 23.18 | 12.12 | 22 | 94934 | 998 | 29478573 |
Major depression | 23.09 | 12.12 | 43 | 94913 | 3792 | 29475779 |
Laboratory test abnormal | 23.01 | 12.12 | 15 | 94941 | 18170 | 29461401 |
Suicidal behaviour | 22.92 | 12.12 | 25 | 94931 | 1340 | 29478231 |
Delusional perception | 22.90 | 12.12 | 11 | 94945 | 154 | 29479417 |
High density lipoprotein decreased | 22.62 | 12.12 | 37 | 94919 | 2942 | 29476629 |
Alcohol use | 22.58 | 12.12 | 38 | 94918 | 3094 | 29476477 |
Gamma-glutamyltransferase increased | 22.46 | 12.12 | 155 | 94801 | 26582 | 29452989 |
Hyperthermia | 22.42 | 12.12 | 74 | 94882 | 9356 | 29470215 |
Bladder cancer | 22.37 | 12.12 | 3 | 94953 | 10124 | 29469447 |
Fungal infection | 22.32 | 12.12 | 8 | 94948 | 13677 | 29465894 |
Hepatic failure | 22.27 | 12.12 | 42 | 94914 | 31470 | 29448101 |
Paradoxical drug reaction | 22.12 | 12.12 | 35 | 94921 | 2706 | 29476865 |
Disorganised speech | 22.09 | 12.12 | 18 | 94938 | 665 | 29478906 |
Osteonecrosis | 21.88 | 12.12 | 8 | 94948 | 13511 | 29466060 |
Flatulence | 21.88 | 12.12 | 15 | 94941 | 17694 | 29461877 |
Salivary gland calculus | 21.88 | 12.12 | 8 | 94948 | 53 | 29479518 |
Compulsive sexual behaviour | 21.81 | 12.12 | 12 | 94944 | 226 | 29479345 |
Patient restraint | 21.77 | 12.12 | 9 | 94947 | 86 | 29479485 |
Acute myeloid leukaemia | 21.75 | 12.12 | 13 | 94943 | 16500 | 29463071 |
Somnambulism | 21.59 | 12.12 | 35 | 94921 | 2763 | 29476808 |
Substance abuse | 21.56 | 12.12 | 59 | 94897 | 6728 | 29472843 |
Confabulation | 21.54 | 12.12 | 10 | 94946 | 129 | 29479442 |
Proteinuria | 21.45 | 12.12 | 12 | 94944 | 15792 | 29463779 |
Injection site erythema | 21.37 | 12.12 | 9 | 94947 | 13947 | 29465624 |
Intentional product misuse | 21.37 | 12.12 | 187 | 94769 | 34474 | 29445097 |
Hallucination, olfactory | 21.37 | 12.12 | 11 | 94945 | 180 | 29479391 |
Red cell distribution width decreased | 21.32 | 12.12 | 11 | 94945 | 181 | 29479390 |
Abdominal pain upper | 21.29 | 12.12 | 112 | 94844 | 60881 | 29418690 |
Drug level above therapeutic | 21.05 | 12.12 | 38 | 94918 | 3272 | 29476299 |
Bone pain | 21.03 | 12.12 | 17 | 94939 | 18435 | 29461136 |
Symptom masked | 20.95 | 12.12 | 16 | 94940 | 537 | 29479034 |
Blood creatine phosphokinase MB increased | 20.92 | 12.12 | 27 | 94929 | 1730 | 29477841 |
Gynaecomastia | 20.91 | 12.12 | 66 | 94890 | 8151 | 29471420 |
Pancreatitis haemorrhagic | 20.87 | 12.12 | 13 | 94943 | 311 | 29479260 |
Sexually inappropriate behaviour | 20.67 | 12.12 | 14 | 94942 | 388 | 29479183 |
Alcohol abuse | 20.58 | 12.12 | 44 | 94912 | 4289 | 29475282 |
Upper gastrointestinal haemorrhage | 20.56 | 12.12 | 24 | 94932 | 21890 | 29457681 |
C-reactive protein increased | 20.53 | 12.12 | 225 | 94731 | 44038 | 29435533 |
Squamous cell carcinoma | 20.49 | 12.12 | 4 | 94952 | 10247 | 29469324 |
Tubulointerstitial nephritis | 20.43 | 12.12 | 16 | 94940 | 17627 | 29461944 |
Cerebral haemorrhage | 20.40 | 12.12 | 44 | 94912 | 31382 | 29448189 |
Panic attack | 20.39 | 12.12 | 66 | 94890 | 8260 | 29471311 |
Ejaculation disorder | 20.35 | 12.12 | 20 | 94936 | 948 | 29478623 |
Transient ischaemic attack | 20.24 | 12.12 | 27 | 94929 | 23243 | 29456328 |
Neoplasm malignant | 20.04 | 12.12 | 15 | 94941 | 16910 | 29462661 |
Bone marrow failure | 19.92 | 12.12 | 36 | 94920 | 27413 | 29452158 |
Abulia | 19.84 | 12.12 | 15 | 94941 | 496 | 29479075 |
Contusion | 19.80 | 12.12 | 44 | 94912 | 31051 | 29448520 |
Frequent bowel movements | 19.79 | 12.12 | 3 | 94953 | 9236 | 29470335 |
Gastrointestinal sounds abnormal | 19.76 | 12.12 | 27 | 94929 | 1829 | 29477742 |
Total cholesterol/HDL ratio increased | 19.57 | 12.12 | 10 | 94946 | 161 | 29479410 |
Blister | 19.55 | 12.12 | 21 | 94935 | 19885 | 29459686 |
Abnormal weight gain | 19.55 | 12.12 | 19 | 94937 | 888 | 29478683 |
Polyuria | 19.54 | 12.12 | 60 | 94896 | 7302 | 29472269 |
Eosinophilia | 19.52 | 12.12 | 130 | 94826 | 22031 | 29457540 |
Somatic hallucination | 19.51 | 12.12 | 6 | 94950 | 21 | 29479550 |
Clostridium difficile colitis | 19.47 | 12.12 | 9 | 94947 | 13203 | 29466368 |
Body temperature increased | 19.44 | 12.12 | 95 | 94861 | 14370 | 29465201 |
Blood ketone body | 19.39 | 12.12 | 8 | 94948 | 76 | 29479495 |
Anxiolytic therapy | 19.30 | 12.12 | 6 | 94950 | 22 | 29479549 |
Drug monitoring procedure incorrectly performed | 19.23 | 12.12 | 11 | 94945 | 224 | 29479347 |
Thirst | 19.22 | 12.12 | 55 | 94901 | 6436 | 29473135 |
Osteomyelitis | 19.20 | 12.12 | 10 | 94946 | 13699 | 29465872 |
Pulmonary valve incompetence | 19.09 | 12.12 | 17 | 94939 | 710 | 29478861 |
Cellulitis | 19.05 | 12.12 | 79 | 94877 | 45761 | 29433810 |
Blood thrombin increased | 18.98 | 12.12 | 4 | 94952 | 0 | 29479571 |
Illiteracy | 18.97 | 12.12 | 5 | 94951 | 8 | 29479563 |
Haemoptysis | 18.83 | 12.12 | 44 | 94912 | 30506 | 29449065 |
Impaired healing | 18.83 | 12.12 | 10 | 94946 | 13548 | 29466023 |
Wrong technique in product usage process | 18.79 | 12.12 | 46 | 94910 | 31382 | 29448189 |
Rash erythematous | 18.78 | 12.12 | 25 | 94931 | 21537 | 29458034 |
Homicidal ideation | 18.70 | 12.12 | 31 | 94925 | 2493 | 29477078 |
Globulins decreased | 18.68 | 12.12 | 10 | 94946 | 178 | 29479393 |
Behaviour disorder | 18.67 | 12.12 | 38 | 94918 | 3578 | 29475993 |
Acute psychosis | 18.65 | 12.12 | 25 | 94931 | 1662 | 29477909 |
Depression | 18.58 | 12.12 | 380 | 94576 | 84767 | 29394804 |
Stereotypy | 18.49 | 12.12 | 16 | 94940 | 643 | 29478928 |
Dry skin | 18.35 | 12.12 | 29 | 94927 | 23278 | 29456293 |
Drug level increased | 18.27 | 12.12 | 113 | 94843 | 18674 | 29460897 |
Contraindicated product administered | 18.24 | 12.12 | 19 | 94937 | 18247 | 29461324 |
Hypoaesthesia | 18.20 | 12.12 | 99 | 94857 | 53368 | 29426203 |
Blood pressure increased | 17.96 | 12.12 | 151 | 94805 | 73652 | 29405919 |
Hypotonia neonatal | 17.92 | 12.12 | 21 | 94935 | 1218 | 29478353 |
Renal disorder | 17.90 | 12.12 | 28 | 94928 | 22567 | 29457004 |
Electrocardiogram QT shortened | 17.89 | 12.12 | 9 | 94947 | 140 | 29479431 |
Pulmonary hypertension | 17.87 | 12.12 | 20 | 94936 | 18588 | 29460983 |
Embolism venous | 17.87 | 12.12 | 22 | 94934 | 1344 | 29478227 |
Asocial behaviour | 17.80 | 12.12 | 7 | 94949 | 58 | 29479513 |
Lung disorder | 17.71 | 12.12 | 45 | 94911 | 30317 | 29449254 |
Drug therapy enhancement | 17.65 | 12.12 | 6 | 94950 | 31 | 29479540 |
Hypomagnesaemia | 17.64 | 12.12 | 18 | 94938 | 17450 | 29462121 |
Pyrexia | 17.58 | 12.12 | 750 | 94206 | 286872 | 29192699 |
Palmar-plantar erythrodysaesthesia syndrome | 17.58 | 12.12 | 13 | 94943 | 14746 | 29464825 |
Reduced facial expression | 17.54 | 12.12 | 16 | 94940 | 690 | 29478881 |
Bacteraemia | 17.43 | 12.12 | 16 | 94940 | 16307 | 29463264 |
Sleep disorder | 17.41 | 12.12 | 136 | 94820 | 24250 | 29455321 |
Lipids increased | 17.39 | 12.12 | 17 | 94939 | 800 | 29478771 |
Epilepsy | 17.38 | 12.12 | 110 | 94846 | 18322 | 29461249 |
Haemophagocytic lymphohistiocytosis | 17.37 | 12.12 | 6 | 94950 | 10498 | 29469073 |
Rectal haemorrhage | 17.36 | 12.12 | 55 | 94901 | 34494 | 29445077 |
Respiration abnormal | 17.34 | 12.12 | 31 | 94925 | 2649 | 29476922 |
Troponin I increased | 17.28 | 12.12 | 26 | 94930 | 1924 | 29477647 |
Inflammation | 17.22 | 12.12 | 29 | 94927 | 22699 | 29456872 |
Neurodegenerative disorder | 17.21 | 12.12 | 10 | 94946 | 210 | 29479361 |
Sluggishness | 17.19 | 12.12 | 33 | 94923 | 2978 | 29476593 |
Body mass index increased | 17.13 | 12.12 | 17 | 94939 | 815 | 29478756 |
Clostridium difficile infection | 17.03 | 12.12 | 16 | 94940 | 16125 | 29463446 |
Blood bilirubin increased | 17.00 | 12.12 | 54 | 94902 | 33839 | 29445732 |
Blood creatine phosphokinase decreased | 16.98 | 12.12 | 13 | 94943 | 438 | 29479133 |
Posterior reversible encephalopathy syndrome | 16.92 | 12.12 | 4 | 94952 | 8972 | 29470599 |
Faeces discoloured | 16.91 | 12.12 | 11 | 94945 | 13340 | 29466231 |
Ageusia | 16.82 | 12.12 | 4 | 94952 | 8934 | 29470637 |
Mobility decreased | 16.81 | 12.12 | 36 | 94920 | 25744 | 29453827 |
Polydipsia psychogenic | 16.72 | 12.12 | 8 | 94948 | 111 | 29479460 |
Neuralgia | 16.67 | 12.12 | 7 | 94949 | 10867 | 29468704 |
Cor pulmonale acute | 16.64 | 12.12 | 10 | 94946 | 224 | 29479347 |
Tangentiality | 16.59 | 12.12 | 8 | 94948 | 113 | 29479458 |
Product use issue | 16.57 | 12.12 | 97 | 94859 | 51347 | 29428224 |
Cataract | 16.55 | 12.12 | 29 | 94927 | 22349 | 29457222 |
Neglect of personal appearance | 16.53 | 12.12 | 8 | 94948 | 114 | 29479457 |
Therapeutic product effect incomplete | 16.52 | 12.12 | 196 | 94760 | 39109 | 29440462 |
Antipsychotic drug level decreased | 16.51 | 12.12 | 17 | 94939 | 852 | 29478719 |
Oromandibular dystonia | 16.46 | 12.12 | 13 | 94943 | 459 | 29479112 |
Anger | 16.45 | 12.12 | 74 | 94882 | 10816 | 29468755 |
Lymphocyte count increased | 16.41 | 12.12 | 31 | 94925 | 2763 | 29476808 |
Hyperosmolar state | 16.40 | 12.12 | 12 | 94944 | 377 | 29479194 |
Joint stiffness | 16.39 | 12.12 | 5 | 94951 | 9468 | 29470103 |
Coagulopathy | 16.38 | 12.12 | 20 | 94936 | 17887 | 29461684 |
Soliloquy | 16.37 | 12.12 | 12 | 94944 | 378 | 29479193 |
Galactorrhoea | 16.26 | 12.12 | 12 | 94944 | 382 | 29479189 |
Off label use | 16.24 | 12.12 | 795 | 94161 | 300005 | 29179566 |
Paraphilia | 16.23 | 12.12 | 7 | 94949 | 75 | 29479496 |
Vascular stenosis | 16.20 | 12.12 | 9 | 94947 | 173 | 29479398 |
Gastrointestinal hypermotility | 16.10 | 12.12 | 8 | 94948 | 121 | 29479450 |
Circadian rhythm sleep disorder | 16.10 | 12.12 | 12 | 94944 | 388 | 29479183 |
Depersonalisation/derealisation disorder | 16.08 | 12.12 | 14 | 94942 | 567 | 29479004 |
Condition aggravated | 15.96 | 12.12 | 597 | 94359 | 145698 | 29333873 |
Device related infection | 15.91 | 12.12 | 16 | 94940 | 15620 | 29463951 |
Dysphoria | 15.91 | 12.12 | 26 | 94930 | 2066 | 29477505 |
Myotonia | 15.89 | 12.12 | 6 | 94950 | 44 | 29479527 |
Parkinsonian rest tremor | 15.87 | 12.12 | 8 | 94948 | 125 | 29479446 |
Movement disorder | 15.80 | 12.12 | 70 | 94886 | 10167 | 29469404 |
Benign ethnic neutropenia | 15.77 | 12.12 | 6 | 94950 | 45 | 29479526 |
Antisocial personality disorder | 15.74 | 12.12 | 5 | 94951 | 20 | 29479551 |
Adrenal insufficiency | 15.73 | 12.12 | 8 | 94948 | 11106 | 29468465 |
Skin lesion | 15.70 | 12.12 | 22 | 94934 | 18550 | 29461021 |
Illusion | 15.69 | 12.12 | 15 | 94941 | 687 | 29478884 |
Chromaturia | 15.61 | 12.12 | 11 | 94945 | 12791 | 29466780 |
Basophil count decreased | 15.60 | 12.12 | 7 | 94949 | 83 | 29479488 |
Cyclothymic disorder | 15.60 | 12.12 | 7 | 94949 | 83 | 29479488 |
Head banging | 15.59 | 12.12 | 8 | 94948 | 130 | 29479441 |
Pain in jaw | 15.57 | 12.12 | 9 | 94947 | 11632 | 29467939 |
Hostility | 15.56 | 12.12 | 16 | 94940 | 801 | 29478770 |
Drug withdrawal syndrome | 15.54 | 12.12 | 105 | 94851 | 17879 | 29461692 |
Affect lability | 15.53 | 12.12 | 34 | 94922 | 3368 | 29476203 |
Night sweats | 15.52 | 12.12 | 15 | 94941 | 14917 | 29464654 |
Hyperammonaemic encephalopathy | 15.50 | 12.12 | 25 | 94931 | 1965 | 29477606 |
Drug level below therapeutic | 15.48 | 12.12 | 39 | 94917 | 4232 | 29475339 |
Hepatitis viral | 15.37 | 12.12 | 13 | 94943 | 506 | 29479065 |
Renal tubular necrosis | 15.33 | 12.12 | 14 | 94942 | 14301 | 29465270 |
Snoring | 15.27 | 12.12 | 30 | 94926 | 2754 | 29476817 |
Homosexuality | 15.23 | 12.12 | 6 | 94950 | 50 | 29479521 |
Gastrectomy | 15.11 | 12.12 | 8 | 94948 | 139 | 29479432 |
Angina unstable | 15.11 | 12.12 | 8 | 94948 | 10857 | 29468714 |
Glassy eyes | 15.10 | 12.12 | 7 | 94949 | 90 | 29479481 |
Graft versus host disease | 15.08 | 12.12 | 6 | 94950 | 9622 | 29469949 |
Injection site bruising | 15.06 | 12.12 | 3 | 94953 | 7577 | 29471994 |
Hypometabolism | 14.92 | 12.12 | 6 | 94950 | 53 | 29479518 |
Chemical poisoning | 14.90 | 12.12 | 7 | 94949 | 93 | 29479478 |
Osteoporosis | 14.87 | 12.12 | 8 | 94948 | 10761 | 29468810 |
Somatic delusion | 14.70 | 12.12 | 7 | 94949 | 96 | 29479475 |
Seizure | 14.60 | 12.12 | 397 | 94559 | 92726 | 29386845 |
Left ventricular dysfunction | 14.60 | 12.12 | 62 | 94894 | 8840 | 29470731 |
Pathogen resistance | 14.57 | 12.12 | 4 | 94952 | 8112 | 29471459 |
Personality disorder | 14.55 | 12.12 | 18 | 94938 | 1105 | 29478466 |
Injection site swelling | 14.54 | 12.12 | 6 | 94950 | 9411 | 29470160 |
Generalised anxiety disorder | 14.54 | 12.12 | 14 | 94942 | 647 | 29478924 |
Strabismus congenital | 14.53 | 12.12 | 5 | 94951 | 27 | 29479544 |
Ear infection | 14.52 | 12.12 | 4 | 94952 | 8096 | 29471475 |
Intestinal perforation | 14.48 | 12.12 | 4 | 94952 | 8082 | 29471489 |
Cardiac dysfunction | 14.48 | 12.12 | 23 | 94933 | 1784 | 29477787 |
Cholestasis | 14.29 | 12.12 | 34 | 94922 | 23428 | 29456143 |
Thrombotic microangiopathy | 14.28 | 12.12 | 5 | 94951 | 8676 | 29470895 |
Cardio-respiratory arrest | 14.24 | 12.12 | 235 | 94721 | 50366 | 29429205 |
Lipomeningocele | 14.23 | 12.12 | 3 | 94953 | 0 | 29479571 |
Schizoid personality disorder | 14.23 | 12.12 | 3 | 94953 | 0 | 29479571 |
Gastric haemorrhage | 14.23 | 12.12 | 6 | 94950 | 9291 | 29470280 |
Tic | 14.22 | 12.12 | 23 | 94933 | 1812 | 29477759 |
Glycosylated haemoglobin increased | 14.20 | 12.12 | 64 | 94892 | 9362 | 29470209 |
Metastases to bone | 14.19 | 12.12 | 7 | 94949 | 9891 | 29469680 |
Accidental overdose | 14.19 | 12.12 | 101 | 94855 | 17492 | 29462079 |
Hyperinsulinism | 14.19 | 12.12 | 6 | 94950 | 61 | 29479510 |
Blood loss anaemia | 14.18 | 12.12 | 3 | 94953 | 7263 | 29472308 |
Myoglobin blood increased | 14.11 | 12.12 | 24 | 94932 | 1971 | 29477600 |
Tricuspid valve sclerosis | 14.09 | 12.12 | 5 | 94951 | 30 | 29479541 |
Cerebellar atrophy | 14.00 | 12.12 | 12 | 94944 | 476 | 29479095 |
Drug eruption | 13.98 | 12.12 | 20 | 94936 | 16721 | 29462850 |
Flushing | 13.98 | 12.12 | 47 | 94909 | 28945 | 29450626 |
Blood urea decreased | 13.97 | 12.12 | 16 | 94940 | 905 | 29478666 |
Cataract congenital | 13.93 | 12.12 | 6 | 94950 | 64 | 29479507 |
Pancreatic carcinoma | 13.85 | 12.12 | 3 | 94953 | 7147 | 29472424 |
Oropharyngeal pain | 13.76 | 12.12 | 48 | 94908 | 29237 | 29450334 |
Mixed delusion | 13.73 | 12.12 | 4 | 94952 | 11 | 29479560 |
Multiple sclerosis relapse | 13.68 | 12.12 | 10 | 94946 | 11409 | 29468162 |
Pseudomonas infection | 13.66 | 12.12 | 9 | 94947 | 10843 | 29468728 |
Staphylococcal bacteraemia | 13.66 | 12.12 | 3 | 94953 | 7076 | 29472495 |
Dextrocardia | 13.63 | 12.12 | 7 | 94949 | 114 | 29479457 |
Legal problem | 13.60 | 12.12 | 8 | 94948 | 172 | 29479399 |
Trismus | 13.53 | 12.12 | 26 | 94930 | 2347 | 29477224 |
Drowning | 13.53 | 12.12 | 11 | 94945 | 405 | 29479166 |
Secondary tic | 13.47 | 12.12 | 4 | 94952 | 12 | 29479559 |
Selective mutism | 13.46 | 12.12 | 6 | 94950 | 70 | 29479501 |
Electrocardiogram PR prolongation | 13.35 | 12.12 | 14 | 94942 | 717 | 29478854 |
Tongue biting | 13.32 | 12.12 | 14 | 94942 | 719 | 29478852 |
Granulocyte count decreased | 13.32 | 12.12 | 13 | 94943 | 611 | 29478960 |
Surgery | 13.24 | 12.12 | 11 | 94945 | 11768 | 29467803 |
Anaphylactic shock | 13.17 | 12.12 | 14 | 94942 | 13322 | 29466249 |
Thought blocking | 13.11 | 12.12 | 7 | 94949 | 124 | 29479447 |
Visual impairment | 13.10 | 12.12 | 50 | 94906 | 29658 | 29449913 |
Localised infection | 13.10 | 12.12 | 15 | 94941 | 13801 | 29465770 |
Eating disorder | 13.09 | 12.12 | 52 | 94904 | 7195 | 29472376 |
Accidental death | 13.07 | 12.12 | 24 | 94932 | 2094 | 29477477 |
Leukaemia | 12.99 | 12.12 | 34 | 94922 | 3776 | 29475795 |
Disseminated intravascular coagulation | 12.95 | 12.12 | 28 | 94928 | 19952 | 29459619 |
Saccadic eye movement | 12.86 | 12.12 | 7 | 94949 | 129 | 29479442 |
Hypotonia | 12.85 | 12.12 | 50 | 94906 | 6852 | 29472719 |
Family stress | 12.76 | 12.12 | 7 | 94949 | 131 | 29479440 |
Motor dysfunction | 12.75 | 12.12 | 45 | 94911 | 5885 | 29473686 |
Echolalia | 12.72 | 12.12 | 9 | 94947 | 268 | 29479303 |
Cytokine release syndrome | 12.71 | 12.12 | 14 | 94942 | 13105 | 29466466 |
Hypokinesia | 12.69 | 12.12 | 53 | 94903 | 7501 | 29472070 |
Oliguria | 12.67 | 12.12 | 4 | 94952 | 7408 | 29472163 |
Product prescribing error | 12.66 | 12.12 | 24 | 94932 | 17952 | 29461619 |
Gambling disorder | 12.56 | 12.12 | 20 | 94936 | 1555 | 29478016 |
Gastric ulcer | 12.55 | 12.12 | 16 | 94940 | 14045 | 29465526 |
Vascular encephalopathy | 12.48 | 12.12 | 7 | 94949 | 137 | 29479434 |
Gait disturbance | 12.45 | 12.12 | 316 | 94640 | 73033 | 29406538 |
Platelet count decreased | 12.44 | 12.12 | 249 | 94707 | 104423 | 29375148 |
Foetal alcohol syndrome | 12.44 | 12.12 | 7 | 94949 | 138 | 29479433 |
Abscess | 12.42 | 12.12 | 8 | 94948 | 9754 | 29469817 |
Hyperventilation | 12.41 | 12.12 | 25 | 94931 | 2337 | 29477234 |
Transfusion | 12.36 | 12.12 | 4 | 94952 | 7294 | 29472277 |
Poor quality sleep | 12.35 | 12.12 | 51 | 94905 | 7182 | 29472389 |
Cardiogenic shock | 12.34 | 12.12 | 27 | 94929 | 19163 | 29460408 |
Pancreatitis | 12.32 | 12.12 | 167 | 94789 | 34347 | 29445224 |
Paraesthesia | 12.28 | 12.12 | 112 | 94844 | 53733 | 29425838 |
Persistent depressive disorder | 12.18 | 12.12 | 9 | 94947 | 287 | 29479284 |
Inferiority complex | 12.16 | 12.12 | 3 | 94953 | 3 | 29479568 |
Glutamate dehydrogenase increased | 12.16 | 12.12 | 3 | 94953 | 3 | 29479568 |
Drug use disorder | 12.14 | 12.12 | 31 | 94925 | 3391 | 29476180 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuroleptic malignant syndrome | 2854.58 | 11.20 | 1329 | 153331 | 23667 | 64320405 |
Sedation | 1567.71 | 11.20 | 1067 | 153593 | 40395 | 64303677 |
Suicide attempt | 1309.13 | 11.20 | 1196 | 153464 | 69811 | 64274261 |
Post-injection delirium sedation syndrome | 1281.95 | 11.20 | 289 | 154371 | 239 | 64343833 |
Agitation | 1092.38 | 11.20 | 1198 | 153462 | 87169 | 64256903 |
Psychotic disorder | 1043.88 | 11.20 | 776 | 153884 | 33802 | 64310270 |
Extrapyramidal disorder | 1041.77 | 11.20 | 625 | 154035 | 18927 | 64325145 |
Sopor | 986.84 | 11.20 | 706 | 153954 | 28955 | 64315117 |
Intentional self-injury | 965.56 | 11.20 | 691 | 153969 | 28353 | 64315719 |
Akathisia | 947.83 | 11.20 | 490 | 154170 | 11020 | 64333052 |
Intentional overdose | 916.98 | 11.20 | 1104 | 153556 | 88840 | 64255232 |
Overdose | 856.10 | 11.20 | 1441 | 153219 | 158125 | 64185947 |
Schizophrenia | 827.37 | 11.20 | 443 | 154217 | 10725 | 64333347 |
Dystonia | 786.01 | 11.20 | 516 | 154144 | 18349 | 64325723 |
Delusion | 773.22 | 11.20 | 502 | 154158 | 17512 | 64326560 |
Aggression | 756.11 | 11.20 | 729 | 153931 | 45503 | 64298569 |
Catatonia | 710.91 | 11.20 | 353 | 154307 | 7267 | 64336805 |
Blood prolactin abnormal | 700.16 | 11.20 | 259 | 154401 | 2473 | 64341599 |
Hallucination, auditory | 700.05 | 11.20 | 461 | 154199 | 16478 | 64327594 |
Toxicity to various agents | 692.83 | 11.20 | 2177 | 152483 | 361336 | 63982736 |
Sexual dysfunction | 649.16 | 11.20 | 315 | 154345 | 6156 | 64337916 |
Arthralgia | 641.79 | 11.20 | 139 | 154521 | 442121 | 63901951 |
Parkinsonism | 635.22 | 11.20 | 408 | 154252 | 13965 | 64330107 |
Somnolence | 621.63 | 11.20 | 1452 | 153208 | 202193 | 64141879 |
Electrocardiogram QT prolonged | 596.71 | 11.20 | 839 | 153821 | 78609 | 64265463 |
Anosognosia | 596.34 | 11.20 | 232 | 154428 | 2573 | 64341499 |
Completed suicide | 563.45 | 11.20 | 1485 | 153175 | 222929 | 64121143 |
Mania | 546.94 | 11.20 | 390 | 154270 | 15896 | 64328176 |
Muscle rigidity | 526.82 | 11.20 | 392 | 154268 | 17081 | 64326991 |
Pain | 515.17 | 11.20 | 349 | 154311 | 553162 | 63790910 |
Disturbance in social behaviour | 513.62 | 11.20 | 229 | 154431 | 3658 | 64340414 |
Weight increased | 498.47 | 11.20 | 1375 | 153285 | 211973 | 64132099 |
Hyperprolactinaemia | 491.20 | 11.20 | 225 | 154435 | 3840 | 64340232 |
Metabolic disorder | 489.25 | 11.20 | 276 | 154384 | 7421 | 64336651 |
Dyskinesia | 479.22 | 11.20 | 530 | 154130 | 38858 | 64305214 |
Salivary hypersecretion | 474.75 | 11.20 | 319 | 154341 | 11794 | 64332278 |
Blood creatine phosphokinase increased | 458.40 | 11.20 | 631 | 154029 | 57927 | 64286145 |
Tardive dyskinesia | 449.29 | 11.20 | 278 | 154382 | 8900 | 64335172 |
Delirium | 447.39 | 11.20 | 681 | 153979 | 68513 | 64275559 |
Drug interaction | 440.11 | 11.20 | 1875 | 152785 | 360208 | 63983864 |
Diarrhoea | 427.07 | 11.20 | 673 | 153987 | 722031 | 63622041 |
Drug abuse | 407.95 | 11.20 | 948 | 153712 | 131426 | 64212646 |
Tachycardia | 406.14 | 11.20 | 1020 | 153640 | 148559 | 64195513 |
Coma | 401.48 | 11.20 | 739 | 153921 | 86876 | 64257196 |
Suicidal ideation | 394.08 | 11.20 | 629 | 154031 | 65913 | 64278159 |
Restlessness | 380.14 | 11.20 | 473 | 154187 | 39312 | 64304760 |
Abnormal behaviour | 370.85 | 11.20 | 430 | 154230 | 33192 | 64310880 |
Oculogyric crisis | 369.24 | 11.20 | 160 | 154500 | 2378 | 64341694 |
Hypothermia | 364.53 | 11.20 | 334 | 154326 | 19522 | 64324550 |
Depressed level of consciousness | 359.47 | 11.20 | 676 | 153984 | 80760 | 64263312 |
Treatment noncompliance | 351.51 | 11.20 | 476 | 154184 | 43006 | 64301066 |
Metabolic syndrome | 351.36 | 11.20 | 151 | 154509 | 2197 | 64341875 |
Rheumatoid arthritis | 347.70 | 11.20 | 10 | 154650 | 164284 | 64179788 |
Psychomotor hyperactivity | 346.18 | 11.20 | 283 | 154377 | 14168 | 64329904 |
Personality change | 340.81 | 11.20 | 228 | 154432 | 8365 | 64335707 |
Dyspnoea | 338.39 | 11.20 | 767 | 153893 | 717907 | 63626165 |
Fatigue | 331.15 | 11.20 | 826 | 153834 | 747904 | 63596168 |
Prescribed overdose | 331.10 | 11.20 | 320 | 154340 | 20011 | 64324061 |
Blood prolactin increased | 327.76 | 11.20 | 163 | 154497 | 3365 | 64340707 |
Pleurothotonus | 321.48 | 11.20 | 141 | 154519 | 2161 | 64341911 |
Dysarthria | 318.56 | 11.20 | 537 | 154123 | 58869 | 64285203 |
Rash | 313.24 | 11.20 | 384 | 154276 | 458165 | 63885907 |
Headache | 300.94 | 11.20 | 505 | 154155 | 528962 | 63815110 |
Myocarditis | 294.14 | 11.20 | 277 | 154383 | 16766 | 64327306 |
Confusional state | 289.87 | 11.20 | 1317 | 153343 | 259827 | 64084245 |
Paranoia | 286.49 | 11.20 | 268 | 154392 | 16084 | 64327988 |
Joint swelling | 280.51 | 11.20 | 84 | 154576 | 215298 | 64128774 |
Psychotic symptom | 279.41 | 11.20 | 125 | 154535 | 2013 | 64342059 |
Pruritus | 278.11 | 11.20 | 206 | 154454 | 312194 | 64031878 |
Infusion related reaction | 263.24 | 11.20 | 40 | 154620 | 164427 | 64179645 |
Hypomania | 260.97 | 11.20 | 165 | 154495 | 5489 | 64338583 |
Miosis | 243.20 | 11.20 | 223 | 154437 | 13043 | 64331029 |
Pain in extremity | 241.13 | 11.20 | 223 | 154437 | 302862 | 64041210 |
Mental impairment | 236.08 | 11.20 | 241 | 154419 | 16102 | 64327970 |
Diabetes mellitus | 230.24 | 11.20 | 499 | 154161 | 65975 | 64278097 |
Cough | 229.11 | 11.20 | 232 | 154428 | 301916 | 64042156 |
Arthropathy | 227.95 | 11.20 | 16 | 154644 | 120951 | 64223121 |
Hallucination | 227.00 | 11.20 | 524 | 154136 | 72264 | 64271808 |
Peripheral swelling | 226.66 | 11.20 | 109 | 154551 | 209044 | 64135028 |
Drug hypersensitivity | 223.20 | 11.20 | 148 | 154512 | 237667 | 64106405 |
Priapism | 222.03 | 11.20 | 131 | 154529 | 3839 | 64340233 |
Nausea | 219.61 | 11.20 | 1055 | 153605 | 784745 | 63559327 |
Tremor | 215.78 | 11.20 | 813 | 153847 | 147417 | 64196655 |
Back pain | 213.61 | 11.20 | 172 | 154488 | 249999 | 64094073 |
Sinusitis | 212.92 | 11.20 | 45 | 154615 | 145883 | 64198189 |
Rhabdomyolysis | 211.58 | 11.20 | 589 | 154071 | 91137 | 64252935 |
Social avoidant behaviour | 207.86 | 11.20 | 132 | 154528 | 4425 | 64339647 |
Persecutory delusion | 201.10 | 11.20 | 125 | 154535 | 4033 | 64340039 |
Abdominal discomfort | 199.08 | 11.20 | 94 | 154566 | 182228 | 64161844 |
Nasopharyngitis | 197.90 | 11.20 | 112 | 154548 | 195961 | 64148111 |
Disorientation | 197.81 | 11.20 | 423 | 154237 | 55405 | 64288667 |
Granulocytopenia | 194.31 | 11.20 | 177 | 154483 | 10263 | 64333809 |
Pneumonia aspiration | 194.01 | 11.20 | 435 | 154225 | 58836 | 64285236 |
Hypersensitivity | 188.74 | 11.20 | 119 | 154541 | 196333 | 64147739 |
Urticaria | 187.16 | 11.20 | 60 | 154600 | 147257 | 64196815 |
Swelling | 186.97 | 11.20 | 75 | 154585 | 160143 | 64183929 |
Antipsychotic drug level above therapeutic | 178.87 | 11.20 | 88 | 154572 | 1773 | 64342299 |
Polydipsia | 176.33 | 11.20 | 131 | 154529 | 5690 | 64338382 |
Bradyphrenia | 176.09 | 11.20 | 160 | 154500 | 9246 | 64334826 |
Serotonin syndrome | 175.60 | 11.20 | 328 | 154332 | 38954 | 64305118 |
Blood triglycerides increased | 168.58 | 11.20 | 217 | 154443 | 18649 | 64325423 |
Obesity | 164.45 | 11.20 | 224 | 154436 | 20338 | 64323734 |
Anxiety | 164.19 | 11.20 | 936 | 153724 | 201713 | 64142359 |
Alopecia | 162.42 | 11.20 | 98 | 154562 | 165592 | 64178480 |
Blood glucose increased | 162.26 | 11.20 | 561 | 154099 | 97512 | 64246560 |
Negativism | 162.04 | 11.20 | 63 | 154597 | 697 | 64343375 |
Antipsychotic drug level increased | 161.44 | 11.20 | 118 | 154542 | 4997 | 64339075 |
Injection site pain | 155.21 | 11.20 | 38 | 154622 | 111370 | 64232702 |
Camptocormia | 154.86 | 11.20 | 54 | 154606 | 427 | 64343645 |
Irritability | 150.93 | 11.20 | 296 | 154364 | 36450 | 64307622 |
Contraindicated product administered | 147.85 | 11.20 | 38 | 154622 | 107791 | 64236281 |
Psychiatric decompensation | 147.60 | 11.20 | 85 | 154575 | 2378 | 64341694 |
Apathy | 145.00 | 11.20 | 156 | 154504 | 11076 | 64332996 |
Mental disorder | 141.62 | 11.20 | 239 | 154421 | 26206 | 64317866 |
Leukopenia | 137.99 | 11.20 | 544 | 154116 | 100698 | 64243374 |
Diabetic ketoacidosis | 135.64 | 11.20 | 251 | 154409 | 29594 | 64314478 |
Thinking abnormal | 134.48 | 11.20 | 152 | 154508 | 11404 | 64332668 |
Anaemia | 133.82 | 11.20 | 463 | 154197 | 378217 | 63965855 |
Speech disorder | 131.92 | 11.20 | 331 | 154329 | 48110 | 64295962 |
Obsessive-compulsive disorder | 131.74 | 11.20 | 102 | 154558 | 4716 | 64339356 |
Increased appetite | 131.12 | 11.20 | 141 | 154519 | 10005 | 64334067 |
Gestational diabetes | 128.70 | 11.20 | 107 | 154553 | 5483 | 64338589 |
Psychomotor retardation | 127.98 | 11.20 | 103 | 154557 | 5040 | 64339032 |
Schizoaffective disorder | 126.13 | 11.20 | 66 | 154594 | 1521 | 64342551 |
Arthritis | 126.07 | 11.20 | 24 | 154636 | 83790 | 64260282 |
Diabetic coma | 125.43 | 11.20 | 59 | 154601 | 1072 | 64343000 |
Respiratory depression | 124.38 | 11.20 | 211 | 154449 | 23232 | 64320840 |
Bipolar disorder | 122.65 | 11.20 | 113 | 154547 | 6648 | 64337424 |
Type 2 diabetes mellitus | 121.90 | 11.20 | 259 | 154401 | 33761 | 64310311 |
Pulmonary embolism | 119.77 | 11.20 | 678 | 153982 | 145678 | 64198394 |
Drug intolerance | 118.21 | 11.20 | 167 | 154493 | 187825 | 64156247 |
Posture abnormal | 115.33 | 11.20 | 82 | 154578 | 3324 | 64340748 |
Psychiatric symptom | 114.10 | 11.20 | 105 | 154555 | 6168 | 64337904 |
Emotional poverty | 114.05 | 11.20 | 48 | 154612 | 661 | 64343411 |
Bradykinesia | 113.90 | 11.20 | 107 | 154553 | 6453 | 64337619 |
Injection site erythema | 113.72 | 11.20 | 17 | 154643 | 70783 | 64273289 |
Stomatitis | 111.40 | 11.20 | 62 | 154598 | 109543 | 64234529 |
Systemic lupus erythematosus | 111.00 | 11.20 | 25 | 154635 | 77587 | 64266485 |
Mutism | 110.82 | 11.20 | 66 | 154594 | 1968 | 64342104 |
Sinus tachycardia | 110.68 | 11.20 | 241 | 154419 | 31947 | 64312125 |
Obsessive thoughts | 109.56 | 11.20 | 52 | 154608 | 965 | 64343107 |
Infection | 108.71 | 11.20 | 172 | 154488 | 184708 | 64159364 |
Galactorrhoea | 107.85 | 11.20 | 77 | 154583 | 3142 | 64340930 |
Cardiac failure congestive | 107.37 | 11.20 | 93 | 154567 | 130487 | 64213585 |
Herpes zoster | 106.47 | 11.20 | 29 | 154631 | 79158 | 64264914 |
Glossodynia | 105.15 | 11.20 | 15 | 154645 | 64681 | 64279391 |
Obsessive-compulsive symptom | 104.29 | 11.20 | 30 | 154630 | 114 | 64343958 |
Loss of consciousness | 102.08 | 11.20 | 657 | 154003 | 147708 | 64196364 |
Interstitial lung disease | 101.19 | 11.20 | 54 | 154606 | 97678 | 64246394 |
Generalised tonic-clonic seizure | 100.93 | 11.20 | 265 | 154395 | 39592 | 64304480 |
Osteoarthritis | 99.92 | 11.20 | 16 | 154644 | 63320 | 64280752 |
Orthostatic hypertension | 98.60 | 11.20 | 42 | 154618 | 597 | 64343475 |
Respiratory arrest | 98.18 | 11.20 | 315 | 154345 | 52670 | 64291402 |
Product dose omission issue | 97.62 | 11.20 | 200 | 154460 | 194547 | 64149525 |
Disinhibition | 97.42 | 11.20 | 63 | 154597 | 2180 | 64341892 |
Cardio-respiratory arrest | 97.04 | 11.20 | 480 | 154180 | 97913 | 64246159 |
Impaired healing | 96.03 | 11.20 | 15 | 154645 | 60458 | 64283614 |
Erythema | 94.71 | 11.20 | 191 | 154469 | 186879 | 64157193 |
Neutropenia | 94.28 | 11.20 | 933 | 153727 | 238691 | 64105381 |
Neuropathy peripheral | 93.86 | 11.20 | 86 | 154574 | 117439 | 64226633 |
Unresponsive to stimuli | 93.74 | 11.20 | 300 | 154360 | 50093 | 64293979 |
Influenza | 93.65 | 11.20 | 71 | 154589 | 106460 | 64237612 |
White blood cell count increased | 91.76 | 11.20 | 357 | 154303 | 65657 | 64278415 |
Neutrophil count increased | 90.58 | 11.20 | 192 | 154468 | 24982 | 64319090 |
Cogwheel rigidity | 90.46 | 11.20 | 66 | 154594 | 2787 | 64341285 |
Dyspnoea exertional | 90.17 | 11.20 | 32 | 154628 | 73698 | 64270374 |
Sudden death | 90.04 | 11.20 | 168 | 154492 | 19928 | 64324144 |
Chest discomfort | 89.17 | 11.20 | 88 | 154572 | 116018 | 64228054 |
Atrial fibrillation | 88.92 | 11.20 | 172 | 154488 | 170917 | 64173155 |
Anaphylactic reaction | 88.89 | 11.20 | 27 | 154633 | 68637 | 64275435 |
Therapeutic product effect decreased | 87.93 | 11.20 | 88 | 154572 | 115263 | 64228809 |
Psoriasis | 87.89 | 11.20 | 31 | 154629 | 71672 | 64272400 |
Drooling | 87.11 | 11.20 | 84 | 154576 | 5235 | 64338837 |
Hallucinations, mixed | 86.95 | 11.20 | 89 | 154571 | 5963 | 64338109 |
Disease progression | 86.93 | 11.20 | 128 | 154532 | 141552 | 64202520 |
Hyponatraemia | 84.36 | 11.20 | 627 | 154033 | 147712 | 64196360 |
Euphoric mood | 84.13 | 11.20 | 91 | 154569 | 6500 | 64337572 |
Depressive symptom | 81.27 | 11.20 | 75 | 154585 | 4421 | 64339651 |
Musculoskeletal pain | 81.15 | 11.20 | 47 | 154613 | 81247 | 64262825 |
Malignant neoplasm progression | 80.57 | 11.20 | 91 | 154569 | 112780 | 64231292 |
Blister | 80.55 | 11.20 | 47 | 154613 | 80920 | 64263152 |
Coma scale abnormal | 80.00 | 11.20 | 96 | 154564 | 7678 | 64336394 |
Cognitive disorder | 79.09 | 11.20 | 301 | 154359 | 54786 | 64289286 |
Mobility decreased | 78.32 | 11.20 | 55 | 154605 | 85785 | 64258287 |
Psoriatic arthropathy | 77.94 | 11.20 | 7 | 154653 | 43274 | 64300798 |
Gastrointestinal haemorrhage | 77.84 | 11.20 | 123 | 154537 | 132189 | 64211883 |
Injection site pruritus | 77.50 | 11.20 | 3 | 154657 | 37823 | 64306249 |
Dyslipidaemia | 77.43 | 11.20 | 103 | 154557 | 9139 | 64334933 |
Self-injurious ideation | 77.38 | 11.20 | 63 | 154597 | 3134 | 64340938 |
Asthma | 76.85 | 11.20 | 69 | 154591 | 95156 | 64248916 |
White blood cell count decreased | 76.49 | 11.20 | 643 | 154017 | 157194 | 64186878 |
Altered state of consciousness | 76.37 | 11.20 | 232 | 154428 | 37670 | 64306402 |
Pneumonia | 76.32 | 11.20 | 917 | 153743 | 558659 | 63785413 |
Refusal of treatment by patient | 76.20 | 11.20 | 97 | 154563 | 8242 | 64335830 |
Disturbance in attention | 75.92 | 11.20 | 244 | 154416 | 40830 | 64303242 |
Antipsychotic drug level below therapeutic | 75.54 | 11.20 | 40 | 154620 | 945 | 64343127 |
Insurance issue | 75.47 | 11.20 | 59 | 154601 | 2767 | 64341305 |
Substance abuse | 73.95 | 11.20 | 101 | 154559 | 9191 | 64334881 |
Feeling guilty | 73.43 | 11.20 | 37 | 154623 | 786 | 64343286 |
Megacolon | 73.05 | 11.20 | 60 | 154600 | 3022 | 64341050 |
Wheezing | 73.03 | 11.20 | 52 | 154608 | 80527 | 64263545 |
Urinary tract infection | 72.68 | 11.20 | 297 | 154363 | 231299 | 64112773 |
Hallucination, visual | 72.45 | 11.20 | 187 | 154473 | 27647 | 64316425 |
Intentional product use issue | 72.40 | 11.20 | 73 | 154587 | 95291 | 64248781 |
Logorrhoea | 72.00 | 11.20 | 67 | 154593 | 3992 | 64340080 |
Type 1 diabetes mellitus | 71.47 | 11.20 | 78 | 154582 | 5627 | 64338445 |
Hypoaesthesia | 71.27 | 11.20 | 141 | 154519 | 138967 | 64205105 |
Hyperthermia | 70.92 | 11.20 | 131 | 154529 | 15419 | 64328653 |
Injection site bruising | 70.91 | 11.20 | 4 | 154656 | 36369 | 64307703 |
Abdominal pain | 70.55 | 11.20 | 449 | 154211 | 311926 | 64032146 |
Abdominal pain upper | 70.14 | 11.20 | 202 | 154458 | 174828 | 64169244 |
Poisoning deliberate | 69.90 | 11.20 | 120 | 154540 | 13338 | 64330734 |
Stupor | 69.57 | 11.20 | 79 | 154581 | 5956 | 64338116 |
Seizure | 68.61 | 11.20 | 656 | 154004 | 166236 | 64177836 |
Product use issue | 68.47 | 11.20 | 165 | 154495 | 151550 | 64192522 |
Rebound psychosis | 68.15 | 11.20 | 22 | 154638 | 133 | 64343939 |
Urinary retention | 67.49 | 11.20 | 265 | 154395 | 48936 | 64295136 |
Myalgia | 67.32 | 11.20 | 178 | 154482 | 158439 | 64185633 |
Malaise | 67.12 | 11.20 | 617 | 154043 | 395630 | 63948442 |
Mental status changes | 66.54 | 11.20 | 307 | 154353 | 60855 | 64283217 |
Agranulocytosis | 66.08 | 11.20 | 222 | 154438 | 38007 | 64306065 |
Poisoning | 65.41 | 11.20 | 155 | 154505 | 21724 | 64322348 |
Acute kidney injury | 65.15 | 11.20 | 726 | 153934 | 448514 | 63895558 |
Hyperphagia | 64.88 | 11.20 | 49 | 154611 | 2182 | 64341890 |
Acute psychosis | 64.76 | 11.20 | 61 | 154599 | 3691 | 64340381 |
Wound | 64.65 | 11.20 | 53 | 154607 | 76424 | 64267648 |
Lower respiratory tract infection | 64.60 | 11.20 | 79 | 154581 | 94535 | 64249537 |
Grandiosity | 64.28 | 11.20 | 30 | 154630 | 535 | 64343537 |
Depression | 64.13 | 11.20 | 697 | 153963 | 182594 | 64161478 |
Injection site swelling | 64.00 | 11.20 | 11 | 154649 | 41342 | 64302730 |
Eosinophilic myocarditis | 63.65 | 11.20 | 34 | 154626 | 818 | 64343254 |
Contusion | 63.26 | 11.20 | 110 | 154550 | 113855 | 64230217 |
Electroencephalogram abnormal | 63.21 | 11.20 | 70 | 154590 | 5133 | 64338939 |
Delusion of grandeur | 62.57 | 11.20 | 30 | 154630 | 570 | 64343502 |
Mydriasis | 62.44 | 11.20 | 123 | 154537 | 15189 | 64328883 |
Withdrawal syndrome | 62.35 | 11.20 | 159 | 154501 | 23333 | 64320739 |
Water intoxication | 61.92 | 11.20 | 32 | 154628 | 718 | 64343354 |
Tension | 61.67 | 11.20 | 60 | 154600 | 3780 | 64340292 |
Duodenal ulcer perforation | 61.28 | 11.20 | 6 | 154654 | 34619 | 64309453 |
Heat stroke | 61.07 | 11.20 | 40 | 154620 | 1415 | 64342657 |
Neutrophil count decreased | 60.72 | 11.20 | 354 | 154306 | 76842 | 64267230 |
Waxy flexibility | 60.18 | 11.20 | 23 | 154637 | 242 | 64343830 |
Amenorrhoea | 59.65 | 11.20 | 76 | 154584 | 6463 | 64337609 |
Hyperammonaemia | 59.09 | 11.20 | 94 | 154566 | 9810 | 64334262 |
Gastrointestinal disorder | 59.07 | 11.20 | 77 | 154583 | 89632 | 64254440 |
Hyperammonaemic encephalopathy | 58.88 | 11.20 | 60 | 154600 | 3998 | 64340074 |
Osteonecrosis of jaw | 58.63 | 11.20 | 12 | 154648 | 39813 | 64304259 |
Upper respiratory tract infection | 58.41 | 11.20 | 53 | 154607 | 72732 | 64271340 |
Basal cell carcinoma | 58.29 | 11.20 | 4 | 154656 | 30834 | 64313238 |
Discomfort | 57.94 | 11.20 | 65 | 154595 | 80813 | 64263259 |
Bronchitis | 57.63 | 11.20 | 108 | 154552 | 108635 | 64235437 |
Bone pain | 57.56 | 11.20 | 21 | 154639 | 47551 | 64296521 |
Muscle spasms | 57.04 | 11.20 | 162 | 154498 | 140861 | 64203211 |
Polyuria | 57.02 | 11.20 | 106 | 154554 | 12537 | 64331535 |
Weight decreased | 56.94 | 11.20 | 426 | 154234 | 285313 | 64058759 |
Inflammation | 56.77 | 11.20 | 44 | 154616 | 65256 | 64278816 |
Cardiac arrest | 56.28 | 11.20 | 591 | 154069 | 153473 | 64190599 |
Diverticulitis | 56.10 | 11.20 | 12 | 154648 | 38606 | 64305466 |
Delusional disorder, persecutory type | 55.96 | 11.20 | 25 | 154635 | 401 | 64343671 |
Dyspepsia | 55.95 | 11.20 | 66 | 154594 | 80246 | 64263826 |
Insomnia | 55.83 | 11.20 | 722 | 153938 | 197114 | 64146958 |
Injection site reaction | 55.79 | 11.20 | 21 | 154639 | 46643 | 64297429 |
Osteoporosis | 55.46 | 11.20 | 16 | 154644 | 42064 | 64302008 |
Hypertonia | 55.32 | 11.20 | 72 | 154588 | 6253 | 64337819 |
Impulsive behaviour | 55.22 | 11.20 | 48 | 154612 | 2615 | 64341457 |
Asthenia | 55.06 | 11.20 | 710 | 153950 | 427334 | 63916738 |
Treatment failure | 54.33 | 11.20 | 125 | 154535 | 116691 | 64227381 |
Blood pressure increased | 54.29 | 11.20 | 221 | 154439 | 172331 | 64171741 |
Behaviour disorder | 54.16 | 11.20 | 60 | 154600 | 4402 | 64339670 |
COVID-19 | 54.00 | 11.20 | 46 | 154614 | 65094 | 64278978 |
Suspiciousness | 53.99 | 11.20 | 27 | 154633 | 564 | 64343508 |
Bipolar I disorder | 53.96 | 11.20 | 40 | 154620 | 1731 | 64342341 |
Inappropriate antidiuretic hormone secretion | 53.19 | 11.20 | 145 | 154515 | 22144 | 64321928 |
Cytomegalovirus infection | 53.15 | 11.20 | 12 | 154648 | 37187 | 64306885 |
Torsade de pointes | 52.98 | 11.20 | 124 | 154536 | 17239 | 64326833 |
Jaundice cholestatic | 52.71 | 11.20 | 83 | 154577 | 8587 | 64335485 |
Autonomic nervous system imbalance | 52.65 | 11.20 | 57 | 154603 | 4075 | 64339997 |
Flat affect | 52.27 | 11.20 | 40 | 154620 | 1817 | 64342255 |
International normalised ratio increased | 52.07 | 11.20 | 68 | 154592 | 79099 | 64264973 |
Oropharyngeal pain | 51.89 | 11.20 | 83 | 154577 | 88784 | 64255288 |
Muscular weakness | 51.70 | 11.20 | 146 | 154514 | 127192 | 64216880 |
Depressed mood | 51.56 | 11.20 | 215 | 154445 | 40797 | 64303275 |
Irritable bowel syndrome | 51.53 | 11.20 | 13 | 154647 | 37356 | 64306716 |
Intentional product misuse | 51.43 | 11.20 | 323 | 154337 | 71972 | 64272100 |
Staring | 51.10 | 11.20 | 44 | 154616 | 2366 | 64341706 |
Screaming | 50.88 | 11.20 | 52 | 154608 | 3477 | 64340595 |
Nasal congestion | 50.85 | 11.20 | 41 | 154619 | 59617 | 64284455 |
Fluid retention | 50.76 | 11.20 | 41 | 154619 | 59565 | 64284507 |
Somnambulism | 50.48 | 11.20 | 62 | 154598 | 5079 | 64338993 |
Flushing | 50.26 | 11.20 | 69 | 154591 | 78579 | 64265493 |
Productive cough | 50.10 | 11.20 | 61 | 154599 | 73142 | 64270930 |
Renal failure | 49.76 | 11.20 | 245 | 154415 | 181443 | 64162629 |
Mucosal inflammation | 49.71 | 11.20 | 46 | 154614 | 62538 | 64281534 |
Renal impairment | 49.67 | 11.20 | 162 | 154498 | 134855 | 64209217 |
Knee arthroplasty | 49.62 | 11.20 | 4 | 154656 | 26995 | 64317077 |
Blunted affect | 49.55 | 11.20 | 23 | 154637 | 405 | 64343667 |
Overweight | 49.51 | 11.20 | 50 | 154610 | 3296 | 64340776 |
Eosinophil count decreased | 49.42 | 11.20 | 45 | 154615 | 2607 | 64341465 |
Enuresis | 49.38 | 11.20 | 46 | 154614 | 2744 | 64341328 |
Brain injury | 49.33 | 11.20 | 87 | 154573 | 9878 | 64334194 |
Haematochezia | 49.02 | 11.20 | 52 | 154608 | 66321 | 64277751 |
Rhinorrhoea | 48.92 | 11.20 | 43 | 154617 | 59926 | 64284146 |
Folliculitis | 48.81 | 11.20 | 7 | 154653 | 30070 | 64314002 |
Delusional disorder, unspecified type | 48.52 | 11.20 | 27 | 154633 | 706 | 64343366 |
Delusion of replacement | 48.36 | 11.20 | 17 | 154643 | 138 | 64343934 |
Leukocytosis | 48.35 | 11.20 | 199 | 154461 | 37541 | 64306531 |
Visceral congestion | 48.28 | 11.20 | 28 | 154632 | 794 | 64343278 |
Pressure of speech | 48.17 | 11.20 | 30 | 154630 | 971 | 64343101 |
Sleep disorder due to general medical condition, insomnia type | 47.98 | 11.20 | 4 | 154656 | 26266 | 64317806 |
Cataract | 47.88 | 11.20 | 32 | 154628 | 51230 | 64292842 |
Trimethylaminuria | 47.73 | 11.20 | 17 | 154643 | 144 | 64343928 |
Chills | 47.57 | 11.20 | 169 | 154491 | 137095 | 64206977 |
Hyperglycaemia | 47.56 | 11.20 | 279 | 154381 | 60689 | 64283383 |
Skin ulcer | 47.44 | 11.20 | 23 | 154637 | 43951 | 64300121 |
Long QT syndrome | 47.30 | 11.20 | 60 | 154600 | 5079 | 64338993 |
Affective disorder | 47.13 | 11.20 | 68 | 154592 | 6512 | 64337560 |
Rash pruritic | 47.02 | 11.20 | 41 | 154619 | 57363 | 64286709 |
Cor pulmonale acute | 46.97 | 11.20 | 25 | 154635 | 597 | 64343475 |
Multiple sclerosis relapse | 46.74 | 11.20 | 20 | 154640 | 41115 | 64302957 |
Somatic symptom disorder of pregnancy | 46.70 | 11.20 | 15 | 154645 | 89 | 64343983 |
Neoplasm progression | 46.42 | 11.20 | 20 | 154640 | 40944 | 64303128 |
Fibromyalgia | 46.33 | 11.20 | 14 | 154646 | 35717 | 64308355 |
Ataxia | 46.20 | 11.20 | 137 | 154523 | 21947 | 64322125 |
Spasmodic dysphonia | 45.97 | 11.20 | 17 | 154643 | 162 | 64343910 |
Hypokinesia | 45.79 | 11.20 | 114 | 154546 | 16482 | 64327590 |
Pulmonary mass | 45.73 | 11.20 | 3 | 154657 | 24013 | 64320059 |
Nephrolithiasis | 45.40 | 11.20 | 24 | 154636 | 43659 | 64300413 |
Anticholinergic syndrome | 45.32 | 11.20 | 43 | 154617 | 2626 | 64341446 |
Haematuria | 45.08 | 11.20 | 47 | 154613 | 60424 | 64283648 |
Pleural effusion | 45.08 | 11.20 | 154 | 154506 | 126405 | 64217667 |
Major depression | 45.01 | 11.20 | 73 | 154587 | 7743 | 64336329 |
Hypertriglyceridaemia | 44.48 | 11.20 | 89 | 154571 | 11116 | 64332956 |
Chronic kidney disease | 44.34 | 11.20 | 44 | 154616 | 57875 | 64286197 |
Thrombosis | 44.12 | 11.20 | 63 | 154597 | 70579 | 64273493 |
Chest pain | 44.10 | 11.20 | 358 | 154302 | 235622 | 64108450 |
Pancreatitis necrotising | 43.86 | 11.20 | 46 | 154614 | 3171 | 64340901 |
Blepharospasm | 43.78 | 11.20 | 47 | 154613 | 3328 | 64340744 |
Abulia | 43.63 | 11.20 | 27 | 154633 | 864 | 64343208 |
General physical health deterioration | 43.50 | 11.20 | 299 | 154361 | 204126 | 64139946 |
Maternal exposure during pregnancy | 43.46 | 11.20 | 104 | 154556 | 95780 | 64248292 |
Eosinophil count increased | 43.30 | 11.20 | 101 | 154559 | 14011 | 64330061 |
Hyperkalaemia | 43.26 | 11.20 | 113 | 154547 | 101016 | 64243056 |
Ascites | 43.14 | 11.20 | 51 | 154609 | 61950 | 64282122 |
Food craving | 43.02 | 11.20 | 32 | 154628 | 1392 | 64342680 |
Cellulitis | 42.92 | 11.20 | 101 | 154559 | 93556 | 64250516 |
Stereotypy | 42.46 | 11.20 | 26 | 154634 | 816 | 64343256 |
Aspiration | 42.46 | 11.20 | 112 | 154548 | 16773 | 64327299 |
Ileus paralytic | 42.35 | 11.20 | 74 | 154586 | 8341 | 64335731 |
Embolism venous | 42.29 | 11.20 | 47 | 154613 | 3460 | 64340612 |
Death | 42.29 | 11.20 | 860 | 153800 | 481845 | 63862227 |
Throat irritation | 42.09 | 11.20 | 13 | 154647 | 32698 | 64311374 |
Breast engorgement | 42.05 | 11.20 | 12 | 154648 | 44 | 64344028 |
Hanging | 41.99 | 11.20 | 14 | 154646 | 95 | 64343977 |
Feeling hot | 41.99 | 11.20 | 29 | 154631 | 45634 | 64298438 |
Melaena | 41.78 | 11.20 | 40 | 154620 | 53508 | 64290564 |
Decreased appetite | 41.73 | 11.20 | 452 | 154208 | 280837 | 64063235 |
Erectile dysfunction | 41.65 | 11.20 | 93 | 154567 | 12534 | 64331538 |
Alanine aminotransferase increased | 41.58 | 11.20 | 513 | 154147 | 138518 | 64205554 |
Diabetic hyperosmolar coma | 41.02 | 11.20 | 24 | 154636 | 692 | 64343380 |
Muscle injury | 40.98 | 11.20 | 7 | 154653 | 26430 | 64317642 |
Angina pectoris | 40.96 | 11.20 | 29 | 154631 | 45052 | 64299020 |
Skin exfoliation | 40.62 | 11.20 | 29 | 154631 | 44856 | 64299216 |
Oromandibular dystonia | 40.53 | 11.20 | 26 | 154634 | 887 | 64343185 |
Drug level increased | 40.45 | 11.20 | 176 | 154484 | 34020 | 64310052 |
Self esteem decreased | 40.43 | 11.20 | 26 | 154634 | 891 | 64343181 |
Asphyxia | 40.41 | 11.20 | 78 | 154582 | 9488 | 64334584 |
Brain stem thrombosis | 40.29 | 11.20 | 8 | 154652 | 0 | 64344072 |
Epilepsy | 39.99 | 11.20 | 173 | 154487 | 33358 | 64310714 |
Fungal infection | 39.97 | 11.20 | 16 | 154644 | 34235 | 64309837 |
Head banging | 39.86 | 11.20 | 21 | 154639 | 491 | 64343581 |
Gout | 39.83 | 11.20 | 3 | 154657 | 21410 | 64322662 |
Malignant catatonia | 39.77 | 11.20 | 19 | 154641 | 358 | 64343714 |
Homicide | 39.64 | 11.20 | 28 | 154632 | 1123 | 64342949 |
Hallucination, olfactory | 39.26 | 11.20 | 20 | 154640 | 435 | 64343637 |
Eosinophilia | 39.12 | 11.20 | 188 | 154472 | 37888 | 64306184 |
Pericarditis | 38.79 | 11.20 | 56 | 154604 | 62460 | 64281612 |
Dementia with Lewy bodies | 38.67 | 11.20 | 23 | 154637 | 684 | 64343388 |
Pain in jaw | 38.66 | 11.20 | 25 | 154635 | 40730 | 64303342 |
Myoclonus | 38.34 | 11.20 | 140 | 154520 | 24978 | 64319094 |
Abnormal weight gain | 38.24 | 11.20 | 36 | 154624 | 2177 | 64341895 |
Illusion | 38.13 | 11.20 | 31 | 154629 | 1539 | 64342533 |
Ketoacidosis | 38.04 | 11.20 | 63 | 154597 | 6800 | 64337272 |
Unevaluable event | 37.91 | 11.20 | 39 | 154621 | 50450 | 64293622 |
Hepatic steatosis | 37.77 | 11.20 | 161 | 154499 | 30846 | 64313226 |
Accidental overdose | 37.65 | 11.20 | 170 | 154490 | 33387 | 64310685 |
Delusion of reference | 37.62 | 11.20 | 14 | 154646 | 136 | 64343936 |
Hyperhidrosis | 37.38 | 11.20 | 461 | 154199 | 124459 | 64219613 |
Compulsive sexual behaviour | 37.15 | 11.20 | 16 | 154644 | 234 | 64343838 |
Condition aggravated | 36.93 | 11.20 | 1161 | 153499 | 371265 | 63972807 |
Torticollis | 36.82 | 11.20 | 35 | 154625 | 2142 | 64341930 |
Ill-defined disorder | 36.64 | 11.20 | 31 | 154629 | 44021 | 64300051 |
Withdrawal catatonia | 36.49 | 11.20 | 14 | 154646 | 149 | 64343923 |
Migraine | 36.15 | 11.20 | 59 | 154601 | 62618 | 64281454 |
Pneumocystis jirovecii pneumonia | 35.52 | 11.20 | 11 | 154649 | 27623 | 64316449 |
Suicidal behaviour | 35.35 | 11.20 | 39 | 154621 | 2848 | 64341224 |
Diet refusal | 35.20 | 11.20 | 23 | 154637 | 810 | 64343262 |
Hypernatraemia | 34.98 | 11.20 | 85 | 154575 | 12104 | 64331968 |
Cardiac failure | 34.81 | 11.20 | 181 | 154479 | 132192 | 64211880 |
Gamma-glutamyltransferase increased | 34.66 | 11.20 | 217 | 154443 | 48293 | 64295779 |
Sciatica | 34.61 | 11.20 | 4 | 154656 | 20260 | 64323812 |
Neck pain | 34.49 | 11.20 | 59 | 154601 | 61474 | 64282598 |
Neuralgia | 34.42 | 11.20 | 10 | 154650 | 26174 | 64317898 |
Ejaculation disorder | 34.42 | 11.20 | 19 | 154641 | 489 | 64343583 |
Burning sensation | 34.39 | 11.20 | 41 | 154619 | 49623 | 64294449 |
Plasma cell mastitis | 34.24 | 11.20 | 9 | 154651 | 22 | 64344050 |
Anaphylactic shock | 34.06 | 11.20 | 15 | 154645 | 30313 | 64313759 |
Eye movement disorder | 34.01 | 11.20 | 61 | 154599 | 7018 | 64337054 |
Thought blocking | 33.85 | 11.20 | 14 | 154646 | 184 | 64343888 |
Impulse-control disorder | 33.69 | 11.20 | 29 | 154631 | 1559 | 64342513 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 33.67 | 11.20 | 30 | 154630 | 1689 | 64342383 |
Metastases to liver | 33.65 | 11.20 | 8 | 154652 | 23933 | 64320139 |
Acute myeloid leukaemia | 33.43 | 11.20 | 12 | 154648 | 27451 | 64316621 |
Sepsis | 33.40 | 11.20 | 372 | 154288 | 229969 | 64114103 |
Drug withdrawal syndrome | 33.24 | 11.20 | 156 | 154504 | 31135 | 64312937 |
Negative symptoms in schizophrenia | 33.06 | 11.20 | 12 | 154648 | 108 | 64343964 |
Gynaecomastia | 33.04 | 11.20 | 55 | 154605 | 5961 | 64338111 |
Limb discomfort | 32.87 | 11.20 | 12 | 154648 | 27163 | 64316909 |
Bone marrow failure | 32.77 | 11.20 | 40 | 154620 | 47912 | 64296160 |
Drug monitoring procedure incorrectly performed | 32.75 | 11.20 | 17 | 154643 | 385 | 64343687 |
Blood cholesterol increased | 32.74 | 11.20 | 219 | 154441 | 49847 | 64294225 |
Joint stiffness | 32.65 | 11.20 | 16 | 154644 | 30388 | 64313684 |
Paraesthesia | 32.59 | 11.20 | 189 | 154471 | 134333 | 64209739 |
Epistaxis | 32.56 | 11.20 | 123 | 154537 | 98008 | 64246064 |
Incoherent | 32.50 | 11.20 | 60 | 154600 | 7058 | 64337014 |
Psychomotor skills impaired | 32.44 | 11.20 | 43 | 154617 | 3802 | 64340270 |
Angioedema | 32.22 | 11.20 | 62 | 154598 | 61759 | 64282313 |
Alcohol use | 32.15 | 11.20 | 47 | 154613 | 4555 | 64339517 |
Aspartate aminotransferase increased | 32.02 | 11.20 | 433 | 154227 | 119355 | 64224717 |
Cystitis | 32.00 | 11.20 | 33 | 154627 | 42642 | 64301430 |
Restless legs syndrome | 31.91 | 11.20 | 102 | 154558 | 17014 | 64327058 |
Kidney infection | 31.81 | 11.20 | 3 | 154657 | 17835 | 64326237 |
Encephalitis toxic | 31.72 | 11.20 | 15 | 154645 | 276 | 64343796 |
High density lipoprotein decreased | 31.56 | 11.20 | 43 | 154617 | 3903 | 64340169 |
Oedema peripheral | 31.56 | 11.20 | 337 | 154323 | 209980 | 64134092 |
Impaired self-care | 31.40 | 11.20 | 33 | 154627 | 2280 | 64341792 |
Echolalia | 31.29 | 11.20 | 16 | 154644 | 351 | 64343721 |
Coronary artery disease | 31.15 | 11.20 | 61 | 154599 | 60372 | 64283700 |
Derealisation | 31.10 | 11.20 | 27 | 154633 | 1468 | 64342604 |
Glassy eyes | 30.84 | 11.20 | 12 | 154648 | 133 | 64343939 |
Myocardial infarction | 30.76 | 11.20 | 252 | 154408 | 165569 | 64178503 |
Lethargy | 30.62 | 11.20 | 287 | 154373 | 72307 | 64271765 |
Night sweats | 30.43 | 11.20 | 25 | 154635 | 36021 | 64308051 |
Myelodysplastic syndrome | 30.40 | 11.20 | 14 | 154646 | 27565 | 64316507 |
Inappropriate affect | 30.37 | 11.20 | 25 | 154635 | 1263 | 64342809 |
Dysphonia | 30.33 | 11.20 | 40 | 154620 | 46342 | 64297730 |
Gastrointestinal sounds abnormal | 30.32 | 11.20 | 47 | 154613 | 4796 | 64339276 |
Oral discharge | 30.19 | 11.20 | 14 | 154646 | 246 | 64343826 |
Distractibility | 30.18 | 11.20 | 19 | 154641 | 627 | 64343445 |
Throat tightness | 30.16 | 11.20 | 9 | 154651 | 23151 | 64320921 |
Drug use disorder | 30.16 | 11.20 | 53 | 154607 | 6001 | 64338071 |
Helplessness | 30.10 | 11.20 | 15 | 154645 | 311 | 64343761 |
Osteonecrosis | 30.10 | 11.20 | 15 | 154645 | 28214 | 64315858 |
Surgery | 30.07 | 11.20 | 15 | 154645 | 28198 | 64315874 |
Sluggishness | 30.03 | 11.20 | 51 | 154609 | 5619 | 64338453 |
Haemorrhage | 30.02 | 11.20 | 94 | 154566 | 79257 | 64264815 |
Polydipsia psychogenic | 29.89 | 11.20 | 13 | 154647 | 195 | 64343877 |
Hyperreflexia | 29.85 | 11.20 | 58 | 154602 | 7090 | 64336982 |
Cerebrovascular stenosis | 29.85 | 11.20 | 12 | 154648 | 146 | 64343926 |
Choreoathetosis | 29.84 | 11.20 | 26 | 154634 | 1421 | 64342651 |
Dry skin | 29.66 | 11.20 | 48 | 154612 | 51113 | 64292959 |
Cyclothymic disorder | 29.59 | 11.20 | 13 | 154647 | 200 | 64343872 |
Dysphoria | 29.48 | 11.20 | 44 | 154616 | 4344 | 64339728 |
Cerebrovascular accident | 29.36 | 11.20 | 201 | 154459 | 137382 | 64206690 |
Pulmonary arterial hypertension | 29.36 | 11.20 | 12 | 154648 | 25355 | 64318717 |
Localised infection | 29.30 | 11.20 | 18 | 154642 | 30143 | 64313929 |
Soliloquy | 29.20 | 11.20 | 18 | 154642 | 572 | 64343500 |
Bezoar | 29.14 | 11.20 | 31 | 154629 | 2172 | 64341900 |
Skin discolouration | 29.09 | 11.20 | 25 | 154635 | 35230 | 64308842 |
Upper gastrointestinal haemorrhage | 29.03 | 11.20 | 25 | 154635 | 35195 | 64308877 |
Accidental death | 28.90 | 11.20 | 40 | 154620 | 3685 | 64340387 |
Ear infection | 28.88 | 11.20 | 10 | 154650 | 23394 | 64320678 |
Foot deformity | 28.84 | 11.20 | 3 | 154657 | 16501 | 64327571 |
Haemophagocytic lymphohistiocytosis | 28.80 | 11.20 | 4 | 154656 | 17605 | 64326467 |
Pulmonary fibrosis | 28.79 | 11.20 | 18 | 154642 | 29860 | 64314212 |
Bursitis | 28.63 | 11.20 | 8 | 154652 | 21477 | 64322595 |
Aspergillus infection | 28.56 | 11.20 | 3 | 154657 | 16376 | 64327696 |
Physical assault | 28.35 | 11.20 | 26 | 154634 | 1520 | 64342552 |
Hip arthroplasty | 28.35 | 11.20 | 8 | 154652 | 21343 | 64322729 |
Hypervolaemia | 28.26 | 11.20 | 30 | 154630 | 38255 | 64305817 |
Joint range of motion decreased | 28.12 | 11.20 | 6 | 154654 | 19337 | 64324735 |
Cardiomyopathy | 28.10 | 11.20 | 128 | 154532 | 25228 | 64318844 |
Faecaloma | 28.09 | 11.20 | 68 | 154592 | 9660 | 64334412 |
Coma scale | 28.08 | 11.20 | 9 | 154651 | 53 | 64344019 |
Antipsychotic drug level decreased | 28.04 | 11.20 | 21 | 154639 | 923 | 64343149 |
Cold-stimulus headache | 27.93 | 11.20 | 7 | 154653 | 13 | 64344059 |
Encephalitis autoimmune | 27.60 | 11.20 | 28 | 154632 | 1856 | 64342216 |
Alcohol abuse | 27.51 | 11.20 | 45 | 154615 | 4807 | 64339265 |
Wrong technique in product usage process | 27.48 | 11.20 | 73 | 154587 | 64901 | 64279171 |
Refusal of examination | 27.45 | 11.20 | 10 | 154650 | 91 | 64343981 |
Dysphagia | 27.29 | 11.20 | 383 | 154277 | 106429 | 64237643 |
Hepatocellular injury | 27.28 | 11.20 | 194 | 154466 | 45041 | 64299031 |
Hot flush | 27.16 | 11.20 | 43 | 154617 | 46192 | 64297880 |
Morose | 27.10 | 11.20 | 8 | 154652 | 34 | 64344038 |
Thirst | 27.05 | 11.20 | 85 | 154575 | 14052 | 64330020 |
Akinesia | 26.85 | 11.20 | 35 | 154625 | 3044 | 64341028 |
Product substitution issue | 26.79 | 11.20 | 99 | 154561 | 17762 | 64326310 |
Asocial behaviour | 26.76 | 11.20 | 9 | 154651 | 63 | 64344009 |
Phagophobia | 26.73 | 11.20 | 8 | 154652 | 36 | 64344036 |
Procedural pain | 26.64 | 11.20 | 3 | 154657 | 15505 | 64328567 |
Urinary incontinence | 26.63 | 11.20 | 163 | 154497 | 35988 | 64308084 |
Peptostreptococcus infection | 26.52 | 11.20 | 9 | 154651 | 65 | 64344007 |
Somatic hallucination | 26.38 | 11.20 | 8 | 154652 | 38 | 64344034 |
Resting tremor | 26.36 | 11.20 | 24 | 154636 | 1390 | 64342682 |
Hypercholesterolaemia | 26.32 | 11.20 | 89 | 154571 | 15284 | 64328788 |
Hyperbilirubinaemia | 26.27 | 11.20 | 9 | 154651 | 21196 | 64322876 |
Candida infection | 26.27 | 11.20 | 22 | 154638 | 31397 | 64312675 |
Tendonitis | 26.20 | 11.20 | 8 | 154652 | 20274 | 64323798 |
Symptom recurrence | 26.13 | 11.20 | 20 | 154640 | 909 | 64343163 |
Abnormal clotting factor | 26.10 | 11.20 | 10 | 154650 | 106 | 64343966 |
Plasma cell myeloma | 25.99 | 11.20 | 44 | 154616 | 46031 | 64298041 |
Body mass index increased | 25.98 | 11.20 | 25 | 154635 | 1554 | 64342518 |
Anger | 25.96 | 11.20 | 90 | 154570 | 15651 | 64328421 |
Hypometabolism | 25.94 | 11.20 | 9 | 154651 | 70 | 64344002 |
Progressive multifocal leukoencephalopathy | 25.81 | 11.20 | 6 | 154654 | 18226 | 64325846 |
Bronchopulmonary aspergillosis | 25.63 | 11.20 | 7 | 154653 | 19078 | 64324994 |
Exhibitionism | 25.57 | 11.20 | 8 | 154652 | 43 | 64344029 |
Dysgeusia | 25.56 | 11.20 | 46 | 154614 | 47001 | 64297071 |
Pulmonary hypertension | 25.45 | 11.20 | 40 | 154620 | 43099 | 64300973 |
Drug abuser | 25.33 | 11.20 | 48 | 154612 | 5760 | 64338312 |
Drug level above therapeutic | 25.25 | 11.20 | 53 | 154607 | 6848 | 64337224 |
Prostate cancer | 25.23 | 11.20 | 8 | 154652 | 19787 | 64324285 |
Glutamate dehydrogenase increased | 25.12 | 11.20 | 7 | 154653 | 23 | 64344049 |
Perseveration | 25.09 | 11.20 | 14 | 154646 | 368 | 64343704 |
Disease recurrence | 25.09 | 11.20 | 145 | 154515 | 31365 | 64312707 |
Septic shock | 25.08 | 11.20 | 149 | 154511 | 105288 | 64238784 |
Affect lability | 25.06 | 11.20 | 62 | 154598 | 8928 | 64335144 |
Reduced facial expression | 24.94 | 11.20 | 28 | 154632 | 2085 | 64341987 |
Antisocial behaviour | 24.91 | 11.20 | 16 | 154644 | 547 | 64343525 |
Bone disorder | 24.77 | 11.20 | 5 | 154655 | 16754 | 64327318 |
Pharyngeal dystonia | 24.74 | 11.20 | 6 | 154654 | 9 | 64344063 |
Hyperlipidaemia | 24.73 | 11.20 | 115 | 154545 | 22861 | 64321211 |
Exposure during pregnancy | 24.69 | 11.20 | 290 | 154370 | 77385 | 64266687 |
Hypomagnesaemia | 24.68 | 11.20 | 32 | 154628 | 37344 | 64306728 |
Device dislocation | 24.54 | 11.20 | 10 | 154650 | 21168 | 64322904 |
Personality disorder | 24.45 | 11.20 | 42 | 154618 | 4669 | 64339403 |
Pancreatitis haemorrhagic | 24.35 | 11.20 | 16 | 154644 | 569 | 64343503 |
Rectal haemorrhage | 24.26 | 11.20 | 72 | 154588 | 61745 | 64282327 |
Febrile neutropenia | 24.16 | 11.20 | 311 | 154349 | 187346 | 64156726 |
Xanthoma | 24.10 | 11.20 | 11 | 154649 | 186 | 64343886 |
Full blood count decreased | 24.07 | 11.20 | 12 | 154648 | 22570 | 64321502 |
Frequent bowel movements | 24.05 | 11.20 | 7 | 154653 | 18298 | 64325774 |
Hepatitis C virus test positive | 24.00 | 11.20 | 13 | 154647 | 322 | 64343750 |
Dissociative disorder | 23.82 | 11.20 | 14 | 154646 | 407 | 64343665 |
Oral candidiasis | 23.76 | 11.20 | 13 | 154647 | 23199 | 64320873 |
Device related infection | 23.74 | 11.20 | 23 | 154637 | 30603 | 64313469 |
Hypersomnia | 23.72 | 11.20 | 102 | 154558 | 19615 | 64324457 |
Haematoma | 23.57 | 11.20 | 47 | 154613 | 46203 | 64297869 |
Myelosuppression | 23.46 | 11.20 | 14 | 154646 | 23816 | 64320256 |
Patient restraint | 23.44 | 11.20 | 9 | 154651 | 96 | 64343976 |
Personality change due to a general medical condition | 23.36 | 11.20 | 10 | 154650 | 144 | 64343928 |
Psychotic disorder due to a general medical condition | 23.23 | 11.20 | 12 | 154648 | 269 | 64343803 |
Neurodegenerative disorder | 23.19 | 11.20 | 14 | 154646 | 428 | 64343644 |
Metastases to bone | 23.11 | 11.20 | 10 | 154650 | 20425 | 64323647 |
Palmar-plantar erythrodysaesthesia syndrome | 23.10 | 11.20 | 21 | 154639 | 28798 | 64315274 |
Squamous cell carcinoma | 23.04 | 11.20 | 3 | 154657 | 13866 | 64330206 |
Blood pressure systolic increased | 22.91 | 11.20 | 53 | 154607 | 49400 | 64294672 |
Clostridium difficile colitis | 22.83 | 11.20 | 19 | 154641 | 27204 | 64316868 |
Total cholesterol/HDL ratio increased | 22.71 | 11.20 | 11 | 154649 | 214 | 64343858 |
Stress | 22.69 | 11.20 | 72 | 154588 | 60462 | 64283610 |
Loss of personal independence in daily activities | 22.64 | 11.20 | 93 | 154567 | 72361 | 64271711 |
Palpitations | 22.62 | 11.20 | 152 | 154508 | 104336 | 64239736 |
Thrombotic microangiopathy | 22.57 | 11.20 | 6 | 154654 | 16649 | 64327423 |
Gastric disorder | 22.55 | 11.20 | 22 | 154638 | 29175 | 64314897 |
Somatic symptom disorder | 22.47 | 11.20 | 25 | 154635 | 1843 | 64342229 |
Sexually inappropriate behaviour | 22.46 | 11.20 | 14 | 154646 | 454 | 64343618 |
Psychotic behaviour | 22.25 | 11.20 | 19 | 154641 | 1010 | 64343062 |
Osteomyelitis | 22.23 | 11.20 | 20 | 154640 | 27567 | 64316505 |
Osteopenia | 22.22 | 11.20 | 5 | 154655 | 15535 | 64328537 |
Multiple organ dysfunction syndrome | 22.21 | 11.20 | 147 | 154513 | 101266 | 64242806 |
Joint effusion | 22.18 | 11.20 | 3 | 154657 | 13470 | 64330602 |
Electrocardiogram abnormal | 22.16 | 11.20 | 77 | 154583 | 13404 | 64330668 |
Staphylococcal infection | 22.15 | 11.20 | 56 | 154604 | 50622 | 64293450 |
Oral pain | 22.08 | 11.20 | 20 | 154640 | 27473 | 64316599 |
Myoglobin blood increased | 22.07 | 11.20 | 30 | 154630 | 2717 | 64341355 |
Electrocardiogram T wave inversion | 22.03 | 11.20 | 41 | 154619 | 4853 | 64339219 |
Right ventricular failure | 22.01 | 11.20 | 12 | 154648 | 21459 | 64322613 |
Hunger | 22.00 | 11.20 | 38 | 154622 | 4243 | 64339829 |
Ulcer | 21.94 | 11.20 | 14 | 154646 | 22976 | 64321096 |
Rash macular | 21.83 | 11.20 | 15 | 154645 | 23670 | 64320402 |
Antiphospholipid antibodies | 21.71 | 11.20 | 9 | 154651 | 119 | 64343953 |
Tic | 21.65 | 11.20 | 29 | 154631 | 2590 | 64341482 |
Judgement impaired | 21.56 | 11.20 | 19 | 154641 | 1054 | 64343018 |
Faeces discoloured | 21.53 | 11.20 | 18 | 154642 | 25711 | 64318361 |
Immunodeficiency | 21.49 | 11.20 | 6 | 154654 | 16118 | 64327954 |
Wrong patient received product | 21.48 | 11.20 | 35 | 154625 | 3727 | 64340345 |
Illness | 21.44 | 11.20 | 13 | 154647 | 21925 | 64322147 |
Injury | 21.41 | 11.20 | 66 | 154594 | 55926 | 64288146 |
Adrenal insufficiency | 21.05 | 11.20 | 14 | 154646 | 22473 | 64321599 |
Anxiolytic therapy | 21.02 | 11.20 | 6 | 154654 | 22 | 64344050 |
Drug therapy enhancement | 21.02 | 11.20 | 6 | 154654 | 22 | 64344050 |
Blood ketone body | 21.00 | 11.20 | 9 | 154651 | 130 | 64343942 |
Pneumonitis | 20.99 | 11.20 | 57 | 154603 | 50308 | 64293764 |
Haemoglobin decreased | 20.98 | 11.20 | 335 | 154325 | 194728 | 64149344 |
Pancytopenia | 20.93 | 11.20 | 231 | 154429 | 143078 | 64200994 |
Delusional perception | 20.89 | 11.20 | 12 | 154648 | 334 | 64343738 |
Tachyphrenia | 20.68 | 11.20 | 24 | 154636 | 1852 | 64342220 |
Hostility | 20.68 | 11.20 | 26 | 154634 | 2181 | 64341891 |
Electrocardiogram J wave abnormal | 20.42 | 11.20 | 5 | 154655 | 8 | 64344064 |
Lip swelling | 20.37 | 11.20 | 28 | 154632 | 31879 | 64312193 |
Foot fracture | 20.35 | 11.20 | 9 | 154651 | 18148 | 64325924 |
Rash erythematous | 20.29 | 11.20 | 55 | 154605 | 48578 | 64295494 |
Oedema | 20.27 | 11.20 | 133 | 154527 | 91802 | 64252270 |
Tongue biting | 20.22 | 11.20 | 23 | 154637 | 1737 | 64342335 |
Visual impairment | 20.20 | 11.20 | 100 | 154560 | 73977 | 64270095 |
Negative thoughts | 20.06 | 11.20 | 20 | 154640 | 1298 | 64342774 |
Tenderness | 20.03 | 11.20 | 11 | 154649 | 19591 | 64324481 |
Gastrooesophageal reflux disease | 20.03 | 11.20 | 117 | 154543 | 83026 | 64261046 |
Bacteraemia | 19.96 | 11.20 | 21 | 154639 | 26890 | 64317182 |
Blood pressure fluctuation | 19.93 | 11.20 | 61 | 154599 | 51810 | 64292262 |
Vomiting | 19.86 | 11.20 | 1100 | 153560 | 550017 | 63794055 |
Incontinence | 19.86 | 11.20 | 69 | 154591 | 12012 | 64332060 |
Drug screen positive | 19.81 | 11.20 | 43 | 154617 | 5686 | 64338386 |
Respiratory tract congestion | 19.78 | 11.20 | 7 | 154653 | 16158 | 64327914 |
Neoplasm malignant | 19.78 | 11.20 | 18 | 154642 | 24670 | 64319402 |
Metastases to lung | 19.75 | 11.20 | 6 | 154654 | 15258 | 64328814 |
Skin reaction | 19.75 | 11.20 | 3 | 154657 | 12349 | 64331723 |
Disorganised speech | 19.70 | 11.20 | 22 | 154638 | 1628 | 64342444 |
Tobacco interaction | 19.68 | 11.20 | 7 | 154653 | 59 | 64344013 |
Acute myocardial infarction | 19.65 | 11.20 | 93 | 154567 | 69625 | 64274447 |
Blood cholesterol abnormal | 19.63 | 11.20 | 28 | 154632 | 2653 | 64341419 |
Homicidal ideation | 19.55 | 11.20 | 31 | 154629 | 3226 | 64340846 |
Skin lesion | 19.52 | 11.20 | 36 | 154624 | 36446 | 64307626 |
Therapy interrupted | 19.40 | 11.20 | 12 | 154648 | 20024 | 64324048 |
Ear pain | 19.34 | 11.20 | 19 | 154641 | 25117 | 64318955 |
Haemoptysis | 19.34 | 11.20 | 57 | 154603 | 48991 | 64295081 |
Flight of ideas | 19.32 | 11.20 | 15 | 154645 | 696 | 64343376 |
Abdominal pain lower | 19.25 | 11.20 | 21 | 154639 | 26448 | 64317624 |
Mouth ulceration | 19.22 | 11.20 | 30 | 154630 | 32414 | 64311658 |
Full blood count abnormal | 19.11 | 11.20 | 26 | 154634 | 29731 | 64314341 |
Panic attack | 19.08 | 11.20 | 100 | 154560 | 20853 | 64323219 |
Cerebral atrophy | 19.01 | 11.20 | 49 | 154611 | 7236 | 64336836 |
Colitis ischaemic | 19 | 11.20 | 73 | 154587 | 13341 | 64330731 |
Paradoxical drug reaction | 18.99 | 11.20 | 44 | 154616 | 6076 | 64337996 |
Delusional disorder, erotomanic type | 18.91 | 11.20 | 6 | 154654 | 34 | 64344038 |
Lung disorder | 18.91 | 11.20 | 78 | 154582 | 60622 | 64283450 |
Femur fracture | 18.88 | 11.20 | 33 | 154627 | 34102 | 64309970 |
Apallic syndrome | 18.86 | 11.20 | 16 | 154644 | 843 | 64343229 |
Gambling disorder | 18.85 | 11.20 | 23 | 154637 | 1871 | 64342201 |
Illness anxiety disorder | 18.82 | 11.20 | 10 | 154650 | 238 | 64343834 |
Blood pressure diastolic abnormal | 18.82 | 11.20 | 3 | 154657 | 11914 | 64332158 |
Arrhythmia | 18.79 | 11.20 | 202 | 154458 | 52742 | 64291330 |
Breast discomfort | 18.65 | 11.20 | 11 | 154649 | 322 | 64343750 |
Blood glucose | 18.49 | 11.20 | 6 | 154654 | 37 | 64344035 |
Consciousness fluctuating | 18.48 | 11.20 | 21 | 154639 | 1584 | 64342488 |
Drop attacks | 18.48 | 11.20 | 17 | 154643 | 998 | 64343074 |
Selective mutism | 18.46 | 11.20 | 7 | 154653 | 72 | 64344000 |
Tachypnoea | 18.45 | 11.20 | 118 | 154542 | 26453 | 64317619 |
Hyperosmolar state | 18.43 | 11.20 | 14 | 154646 | 629 | 64343443 |
Hypotonia | 18.40 | 11.20 | 64 | 154596 | 11148 | 64332924 |
Rash papular | 18.38 | 11.20 | 9 | 154651 | 17104 | 64326968 |
Tumour lysis syndrome | 18.33 | 11.20 | 12 | 154648 | 19428 | 64324644 |
Psychogenic visual disorder | 18.28 | 11.20 | 5 | 154655 | 15 | 64344057 |
Heart rate decreased | 18.27 | 11.20 | 69 | 154591 | 54998 | 64289074 |
Compulsions | 18.26 | 11.20 | 11 | 154649 | 335 | 64343737 |
Hypersexuality | 18.14 | 11.20 | 20 | 154640 | 1459 | 64342613 |
Haemoglobin urine | 18.10 | 11.20 | 8 | 154652 | 125 | 64343947 |
Differential white blood cell count abnormal | 18.05 | 11.20 | 22 | 154638 | 1788 | 64342284 |
Parkinsonian rest tremor | 17.95 | 11.20 | 10 | 154650 | 262 | 64343810 |
Injection site haemorrhage | 17.95 | 11.20 | 19 | 154641 | 24259 | 64319813 |
Blood thrombin increased | 17.91 | 11.20 | 4 | 154656 | 3 | 64344069 |
Inferiority complex | 17.91 | 11.20 | 4 | 154656 | 3 | 64344069 |
Skin necrosis | 17.89 | 11.20 | 6 | 154654 | 14323 | 64329749 |
Communication disorder | 17.89 | 11.20 | 32 | 154628 | 3674 | 64340398 |
Lymphadenopathy | 17.87 | 11.20 | 55 | 154605 | 46631 | 64297441 |
Gastric ulcer | 17.87 | 11.20 | 28 | 154632 | 30206 | 64313866 |
Brain oedema | 17.85 | 11.20 | 102 | 154558 | 21973 | 64322099 |
Symptom masked | 17.83 | 11.20 | 18 | 154642 | 1186 | 64342886 |
Limb injury | 17.82 | 11.20 | 18 | 154642 | 23487 | 64320585 |
Deafness | 17.77 | 11.20 | 11 | 154649 | 18348 | 64325724 |
Flatulence | 17.53 | 11.20 | 37 | 154623 | 35629 | 64308443 |
Coagulopathy | 17.53 | 11.20 | 31 | 154629 | 31889 | 64312183 |
Slow speech | 17.52 | 11.20 | 23 | 154637 | 2014 | 64342058 |
Bronchiectasis | 17.52 | 11.20 | 6 | 154654 | 14134 | 64329938 |
Haemorrhoids | 17.50 | 11.20 | 19 | 154641 | 23982 | 64320090 |
Electrocardiogram QT interval abnormal | 17.39 | 11.20 | 10 | 154650 | 279 | 64343793 |
Viral infection | 17.34 | 11.20 | 38 | 154622 | 36102 | 64307970 |
Saccadic eye movement | 17.33 | 11.20 | 8 | 154652 | 139 | 64343933 |
Swelling face | 17.23 | 11.20 | 78 | 154582 | 59088 | 64284984 |
Alcoholism | 17.13 | 11.20 | 30 | 154630 | 3387 | 64340685 |
Musculoskeletal disorder | 16.96 | 11.20 | 11 | 154649 | 17895 | 64326177 |
Respiratory dyskinesia | 16.93 | 11.20 | 6 | 154654 | 50 | 64344022 |
Pseudomonas infection | 16.92 | 11.20 | 11 | 154649 | 17872 | 64326200 |
Meige's syndrome | 16.91 | 11.20 | 4 | 154656 | 5 | 64344067 |
Monocyte count decreased | 16.88 | 11.20 | 27 | 154633 | 2830 | 64341242 |
Protrusion tongue | 16.87 | 11.20 | 11 | 154649 | 386 | 64343686 |
Tubo-ovarian abscess | 16.86 | 11.20 | 10 | 154650 | 296 | 64343776 |
Skin cancer | 16.83 | 11.20 | 4 | 154656 | 11970 | 64332102 |
Benign ethnic neutropenia | 16.83 | 11.20 | 6 | 154654 | 51 | 64344021 |
Secretion discharge | 16.81 | 11.20 | 4 | 154656 | 11960 | 64332112 |
Tooth infection | 16.75 | 11.20 | 7 | 154653 | 14594 | 64329478 |
Ideas of reference | 16.64 | 11.20 | 8 | 154652 | 153 | 64343919 |
Drug level decreased | 16.62 | 11.20 | 63 | 154597 | 11440 | 64332632 |
Extrasystoles | 16.57 | 11.20 | 44 | 154616 | 6614 | 64337458 |
Pancreatitis | 16.55 | 11.20 | 217 | 154443 | 59390 | 64284682 |
Self-medication | 16.54 | 11.20 | 33 | 154627 | 4112 | 64339960 |
Extensor plantar response | 16.46 | 11.20 | 20 | 154640 | 1620 | 64342452 |
Uveitis | 16.44 | 11.20 | 5 | 154655 | 12703 | 64331369 |
Blood creatine phosphokinase decreased | 16.42 | 11.20 | 14 | 154646 | 743 | 64343329 |
Troponin T increased | 16.39 | 11.20 | 24 | 154636 | 2329 | 64341743 |
Substance use | 16.31 | 11.20 | 13 | 154647 | 627 | 64343445 |
Breast cancer | 16.29 | 11.20 | 28 | 154632 | 29120 | 64314952 |
Poverty of thought content | 16.24 | 11.20 | 6 | 154654 | 57 | 64344015 |
Breast enlargement | 16.21 | 11.20 | 18 | 154642 | 1324 | 64342748 |
Obstructive airways disorder | 16.20 | 11.20 | 19 | 154641 | 23166 | 64320906 |
Low density lipoprotein increased | 16.17 | 11.20 | 48 | 154612 | 7692 | 64336380 |
Dissociative identity disorder | 16.15 | 11.20 | 6 | 154654 | 58 | 64344014 |
Illiteracy | 16.12 | 11.20 | 5 | 154655 | 26 | 64344046 |
Lactic acidosis | 16.11 | 11.20 | 84 | 154576 | 61326 | 64282746 |
Pathogen resistance | 16.11 | 11.20 | 5 | 154655 | 12538 | 64331534 |
Paraphilia | 16.06 | 11.20 | 6 | 154654 | 59 | 64344013 |
Skin infection | 16.01 | 11.20 | 8 | 154652 | 15029 | 64329043 |
Myocardial reperfusion injury | 15.96 | 11.20 | 5 | 154655 | 27 | 64344045 |
Dizziness | 15.95 | 11.20 | 856 | 153804 | 429307 | 63914765 |
Cerebellar atrophy | 15.88 | 11.20 | 16 | 154644 | 1052 | 64343020 |
Joint injury | 15.83 | 11.20 | 19 | 154641 | 22928 | 64321144 |
Echopraxia | 15.81 | 11.20 | 5 | 154655 | 28 | 64344044 |
Troponin increased | 15.79 | 11.20 | 76 | 154584 | 15323 | 64328749 |
Opisthotonus | 15.77 | 11.20 | 13 | 154647 | 658 | 64343414 |
Myocardial hypoxia | 15.77 | 11.20 | 4 | 154656 | 8 | 64344064 |
Blood osmolarity increased | 15.76 | 11.20 | 12 | 154648 | 541 | 64343531 |
Exostosis | 15.73 | 11.20 | 4 | 154656 | 11434 | 64332638 |
Postictal paralysis | 15.70 | 11.20 | 10 | 154650 | 337 | 64343735 |
Glycosylated haemoglobin increased | 15.67 | 11.20 | 78 | 154582 | 15941 | 64328131 |
Prolactin-producing pituitary tumour | 15.57 | 11.20 | 7 | 154653 | 114 | 64343958 |
Abscess | 15.55 | 11.20 | 14 | 154646 | 19290 | 64324782 |
Paraesthesia oral | 15.54 | 11.20 | 6 | 154654 | 13125 | 64330947 |
Spinal compression fracture | 15.53 | 11.20 | 8 | 154652 | 14767 | 64329305 |
Tricuspid valve sclerosis | 15.52 | 11.20 | 5 | 154655 | 30 | 64344042 |
Cerebellar syndrome | 15.50 | 11.20 | 36 | 154624 | 4980 | 64339092 |
Pharyngeal oedema | 15.46 | 11.20 | 9 | 154651 | 15522 | 64328550 |
Movement disorder | 15.46 | 11.20 | 98 | 154562 | 21902 | 64322170 |
Constricted affect | 15.45 | 11.20 | 4 | 154656 | 9 | 64344063 |
Tubulointerstitial nephritis | 15.25 | 11.20 | 32 | 154628 | 30877 | 64313195 |
Ageusia | 15.24 | 11.20 | 7 | 154653 | 13806 | 64330266 |
Rotator cuff syndrome | 15.24 | 11.20 | 5 | 154655 | 12102 | 64331970 |
Wrong patient | 15.22 | 11.20 | 8 | 154652 | 186 | 64343886 |
Antidepressant drug level increased | 15.11 | 11.20 | 10 | 154650 | 360 | 64343712 |
Inborn error of metabolism | 15.11 | 11.20 | 3 | 154657 | 0 | 64344072 |
Psychiatric evaluation abnormal | 15.11 | 11.20 | 3 | 154657 | 0 | 64344072 |
Pseudogynaecomastia | 15.11 | 11.20 | 3 | 154657 | 0 | 64344072 |
Skin disorder | 15.09 | 11.20 | 27 | 154633 | 27653 | 64316419 |
Obsessive-compulsive personality disorder | 15.09 | 11.20 | 7 | 154653 | 123 | 64343949 |
Circadian rhythm sleep disorder | 15.04 | 11.20 | 12 | 154648 | 580 | 64343492 |
Excessive masturbation | 15.00 | 11.20 | 6 | 154654 | 72 | 64344000 |
Tooth disorder | 14.98 | 11.20 | 19 | 154641 | 22383 | 64321689 |
Sneezing | 14.95 | 11.20 | 9 | 154651 | 15242 | 64328830 |
Dyspraxia | 14.94 | 11.20 | 9 | 154651 | 274 | 64343798 |
Feelings of worthlessness | 14.86 | 11.20 | 11 | 154649 | 475 | 64343597 |
Chorea | 14.81 | 11.20 | 21 | 154639 | 1979 | 64342093 |
Bladder cancer | 14.78 | 11.20 | 4 | 154656 | 10970 | 64333102 |
Oxygen saturation decreased | 14.77 | 11.20 | 175 | 154485 | 107001 | 64237071 |
Ketosis-prone diabetes mellitus | 14.63 | 11.20 | 4 | 154656 | 12 | 64344060 |
Mixed delusion | 14.63 | 11.20 | 4 | 154656 | 12 | 64344060 |
Off label use | 14.57 | 11.20 | 1313 | 153347 | 631493 | 63712579 |
Muscle contractions involuntary | 14.54 | 11.20 | 27 | 154633 | 3190 | 64340882 |
Drowning | 14.53 | 11.20 | 13 | 154647 | 736 | 64343336 |
Renal tubular necrosis | 14.52 | 11.20 | 19 | 154641 | 22091 | 64321981 |
Organic erectile dysfunction | 14.50 | 11.20 | 6 | 154654 | 79 | 64343993 |
Agitated depression | 14.49 | 11.20 | 9 | 154651 | 290 | 64343782 |
Grip strength decreased | 14.48 | 11.20 | 5 | 154655 | 11719 | 64332353 |
Gastroenteritis | 14.45 | 11.20 | 31 | 154629 | 29680 | 64314392 |
Neutrophilia | 14.45 | 11.20 | 42 | 154618 | 6652 | 64337420 |
Drug ineffective | 14.43 | 11.20 | 2259 | 152401 | 837988 | 63506084 |
Thyroid disorder | 14.42 | 11.20 | 5 | 154655 | 11687 | 64332385 |
Libido decreased | 14.41 | 11.20 | 34 | 154626 | 4750 | 64339322 |
Congestive cardiomyopathy | 14.41 | 11.20 | 56 | 154604 | 10288 | 64333784 |
Premature delivery | 14.36 | 11.20 | 14 | 154646 | 18575 | 64325497 |
Product storage error | 14.31 | 11.20 | 7 | 154653 | 13311 | 64330761 |
Proteinuria | 14.27 | 11.20 | 28 | 154632 | 27695 | 64316377 |
Fear | 14.26 | 11.20 | 90 | 154570 | 20081 | 64323991 |
Anterograde amnesia | 14.21 | 11.20 | 12 | 154648 | 628 | 64343444 |
Muscle twitching | 14.21 | 11.20 | 86 | 154574 | 18912 | 64325160 |
Pica | 14.18 | 11.20 | 5 | 154655 | 41 | 64344031 |
Pupillary reflex impaired | 14.15 | 11.20 | 26 | 154634 | 3047 | 64341025 |
Neglect of personal appearance | 14.10 | 11.20 | 7 | 154653 | 144 | 64343928 |
Toxic epidermal necrolysis | 14.07 | 11.20 | 44 | 154616 | 37122 | 64306950 |
Tangentiality | 14.01 | 11.20 | 7 | 154653 | 146 | 64343926 |
Enthesopathy | 13.99 | 11.20 | 3 | 154657 | 9635 | 64334437 |
Slow response to stimuli | 13.98 | 11.20 | 18 | 154642 | 1547 | 64342525 |
Lacrimation increased | 13.97 | 11.20 | 14 | 154646 | 18332 | 64325740 |
Secondary tic | 13.95 | 11.20 | 4 | 154656 | 15 | 64344057 |
Disseminated intravascular coagulation | 13.94 | 11.20 | 36 | 154624 | 32312 | 64311760 |
Sinus disorder | 13.94 | 11.20 | 12 | 154648 | 16896 | 64327176 |
Product packaging confusion | 13.92 | 11.20 | 8 | 154652 | 223 | 64343849 |
Cerebral haemorrhage | 13.91 | 11.20 | 69 | 154591 | 51021 | 64293051 |
Pneumothorax | 13.89 | 11.20 | 23 | 154637 | 24275 | 64319797 |
Bundle branch block right | 13.83 | 11.20 | 55 | 154605 | 10214 | 64333858 |
Blood pressure diastolic decreased | 13.81 | 11.20 | 20 | 154640 | 22281 | 64321791 |
End stage renal disease | 13.77 | 11.20 | 4 | 154656 | 10471 | 64333601 |
Graft versus host disease | 13.76 | 11.20 | 8 | 154652 | 13805 | 64330267 |
Schizophreniform disorder | 13.75 | 11.20 | 7 | 154653 | 152 | 64343920 |
Shock haemorrhagic | 13.74 | 11.20 | 12 | 154648 | 16779 | 64327293 |
Wrong drug | 13.69 | 11.20 | 8 | 154652 | 230 | 64343842 |
Tongue movement disturbance | 13.65 | 11.20 | 9 | 154651 | 322 | 64343750 |
Granulocyte count decreased | 13.53 | 11.20 | 16 | 154644 | 1260 | 64342812 |
Staphylococcal bacteraemia | 13.53 | 11.20 | 4 | 154656 | 10351 | 64333721 |
Skin fissures | 13.43 | 11.20 | 4 | 154656 | 10302 | 64333770 |
Cyst | 13.42 | 11.20 | 6 | 154654 | 12021 | 64332051 |
Transfusion | 13.39 | 11.20 | 14 | 154646 | 17980 | 64326092 |
Injection site mass | 13.35 | 11.20 | 13 | 154647 | 17257 | 64326815 |
Chemical poisoning | 13.35 | 11.20 | 7 | 154653 | 162 | 64343910 |
Coordination abnormal | 13.34 | 11.20 | 71 | 154589 | 14893 | 64329179 |
Nodule | 13.32 | 11.20 | 14 | 154646 | 17933 | 64326139 |
Complication associated with device | 13.31 | 11.20 | 10 | 154650 | 15070 | 64329002 |
Floppy iris syndrome | 13.31 | 11.20 | 9 | 154651 | 336 | 64343736 |
Salivary gland calculus | 13.27 | 11.20 | 8 | 154652 | 244 | 64343828 |
Affective ambivalence | 13.19 | 11.20 | 4 | 154656 | 19 | 64344053 |
Increased tendency to bruise | 13.19 | 11.20 | 3 | 154657 | 9252 | 64334820 |
Sputum discoloured | 13.17 | 11.20 | 14 | 154646 | 17842 | 64326230 |
Confabulation | 13.17 | 11.20 | 10 | 154650 | 449 | 64343623 |
Parkinsonian gait | 13.14 | 11.20 | 13 | 154647 | 836 | 64343236 |
Ventricular tachyarrhythmia | 13.10 | 11.20 | 8 | 154652 | 250 | 64343822 |
Lymphocyte count | 13.03 | 11.20 | 3 | 154657 | 3 | 64344069 |
Eye pain | 13.02 | 11.20 | 36 | 154624 | 31589 | 64312483 |
Coprolalia | 12.97 | 11.20 | 5 | 154655 | 54 | 64344018 |
Posturing | 12.96 | 11.20 | 14 | 154646 | 998 | 64343074 |
Immune system disorder | 12.95 | 11.20 | 3 | 154657 | 9138 | 64334934 |
Eosinophil count abnormal | 12.94 | 11.20 | 11 | 154649 | 581 | 64343491 |
Gastroenteritis viral | 12.91 | 11.20 | 17 | 154643 | 19712 | 64324360 |
Alcohol problem | 12.89 | 11.20 | 5 | 154655 | 55 | 64344017 |
Clostridium difficile infection | 12.87 | 11.20 | 44 | 154616 | 36119 | 64307953 |
Nephrogenic diabetes insipidus | 12.79 | 11.20 | 19 | 154641 | 1868 | 64342204 |
Angina unstable | 12.72 | 11.20 | 11 | 154649 | 15456 | 64328616 |
Drug dependence | 12.72 | 11.20 | 129 | 154531 | 33183 | 64310889 |
Pharyngeal dyskinesia | 12.71 | 11.20 | 4 | 154656 | 22 | 64344050 |
Eosinophilic pleural effusion | 12.68 | 11.20 | 8 | 154652 | 265 | 64343807 |
Globulins decreased | 12.65 | 11.20 | 9 | 154651 | 365 | 64343707 |
Fluid intake restriction | 12.65 | 11.20 | 5 | 154655 | 58 | 64344014 |
Device occlusion | 12.64 | 11.20 | 4 | 154656 | 9909 | 64334163 |
Poor venous access | 12.64 | 11.20 | 7 | 154653 | 12410 | 64331662 |
Pituitary tumour benign | 12.64 | 11.20 | 21 | 154639 | 2272 | 64341800 |
Vascular stenosis | 12.59 | 11.20 | 10 | 154650 | 480 | 64343592 |
Electrocardiogram J wave | 12.57 | 11.20 | 5 | 154655 | 59 | 64344013 |
Neuroleptic-induced deficit syndrome | 12.56 | 11.20 | 4 | 154656 | 23 | 64344049 |
Musculoskeletal stiffness | 12.45 | 11.20 | 214 | 154446 | 122992 | 64221080 |
Troponin I increased | 12.44 | 11.20 | 28 | 154632 | 3793 | 64340279 |
Gun shot wound | 12.39 | 11.20 | 14 | 154646 | 1050 | 64343022 |
Dermatitis | 12.36 | 11.20 | 15 | 154645 | 18014 | 64326058 |
Fistula | 12.34 | 11.20 | 4 | 154656 | 9757 | 64334315 |
Respiratory tract infection | 12.33 | 11.20 | 47 | 154613 | 37360 | 64306712 |
Panic disorder | 12.29 | 11.20 | 23 | 154637 | 2734 | 64341338 |
Gaze palsy | 12.28 | 11.20 | 22 | 154638 | 2528 | 64341544 |
Blood urea decreased | 12.21 | 11.20 | 23 | 154637 | 2748 | 64341324 |
Breathing-related sleep disorder | 12.18 | 11.20 | 7 | 154653 | 195 | 64343877 |
Creatinine renal clearance decreased | 12.18 | 11.20 | 10 | 154650 | 14411 | 64329661 |
Product measured potency issue | 12.15 | 11.20 | 7 | 154653 | 196 | 64343876 |
Circulatory collapse | 12.11 | 11.20 | 129 | 154531 | 33603 | 64310469 |
Spinal disorder | 12.09 | 11.20 | 3 | 154657 | 8719 | 64335353 |
Anticonvulsant drug level increased | 12.09 | 11.20 | 21 | 154639 | 2356 | 64341716 |
Sedation complication | 12.02 | 11.20 | 53 | 154607 | 10301 | 64333771 |
Brief psychotic disorder, with postpartum onset | 12.02 | 11.20 | 4 | 154656 | 27 | 64344045 |
Dependent personality disorder | 12.01 | 11.20 | 6 | 154654 | 125 | 64343947 |
Sinus bradycardia | 12.00 | 11.20 | 95 | 154565 | 22798 | 64321274 |
Paternal exposure timing unspecified | 12.00 | 11.20 | 5 | 154655 | 67 | 64344005 |
Frontotemporal dementia | 12.00 | 11.20 | 10 | 154650 | 514 | 64343558 |
Acquired haemophilia | 11.98 | 11.20 | 17 | 154643 | 1603 | 64342469 |
Glucocorticoids increased | 11.97 | 11.20 | 6 | 154654 | 126 | 64343946 |
Dry eye | 11.97 | 11.20 | 33 | 154627 | 28986 | 64315086 |
Intestinal pseudo-obstruction | 11.95 | 11.20 | 19 | 154641 | 1981 | 64342091 |
Pulmonary valve incompetence | 11.93 | 11.20 | 17 | 154643 | 1609 | 64342463 |
Pulmonary congestion | 11.93 | 11.20 | 98 | 154562 | 23782 | 64320290 |
Hernia | 11.88 | 11.20 | 9 | 154651 | 13509 | 64330563 |
Blood chloride decreased | 11.88 | 11.20 | 42 | 154618 | 7374 | 64336698 |
Live birth | 11.87 | 11.20 | 6 | 154654 | 11198 | 64332874 |
Postoperative wound infection | 11.78 | 11.20 | 5 | 154655 | 10331 | 64333741 |
Intestinal infarction | 11.77 | 11.20 | 15 | 154645 | 1276 | 64342796 |
Terminal insomnia | 11.76 | 11.20 | 13 | 154647 | 951 | 64343121 |
Menstruation irregular | 11.75 | 11.20 | 30 | 154630 | 4405 | 64339667 |
Intervertebral disc protrusion | 11.65 | 11.20 | 19 | 154641 | 20172 | 64323900 |
Abdominal distension | 11.65 | 11.20 | 161 | 154499 | 95833 | 64248239 |
Spinal pain | 11.62 | 11.20 | 8 | 154652 | 12613 | 64331459 |
Hyperthermia malignant | 11.57 | 11.20 | 21 | 154639 | 2438 | 64341634 |
Motor dysfunction | 11.57 | 11.20 | 56 | 154604 | 11317 | 64332755 |
Ovarian cyst | 11.53 | 11.20 | 6 | 154654 | 11012 | 64333060 |
Lymphocyte count increased | 11.51 | 11.20 | 32 | 154628 | 4943 | 64339129 |
Respiratory disorder | 11.50 | 11.20 | 46 | 154614 | 36065 | 64308007 |
Neuroglycopenia | 11.50 | 11.20 | 5 | 154655 | 75 | 64343997 |
Inappropriate schedule of product administration | 11.48 | 11.20 | 154 | 154506 | 92132 | 64251940 |
Myotonia | 11.40 | 11.20 | 7 | 154653 | 221 | 64343851 |
Hypoventilation | 11.39 | 11.20 | 36 | 154624 | 5970 | 64338102 |
Gait disturbance | 11.31 | 11.20 | 513 | 154147 | 171642 | 64172430 |
Autoimmune hepatitis | 11.30 | 11.20 | 5 | 154655 | 10079 | 64333993 |
Bilirubin urine present | 11.30 | 11.20 | 8 | 154652 | 322 | 64343750 |
Mass | 11.24 | 11.20 | 12 | 154648 | 15264 | 64328808 |
Enterococcal infection | 11.24 | 11.20 | 10 | 154650 | 13856 | 64330216 |
Cyanosis central | 11.23 | 11.20 | 7 | 154653 | 227 | 64343845 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Exposure during pregnancy | 33.88 | 28.61 | 40 | 465 | 1283 | 82890 |
Source | Code | Description |
---|---|---|
ATC | N05AH03 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diazepines, oxazepines, thiazepines and oxepines |
FDA EPC | N0000175430 | Atypical Antipsychotic |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:48876 | muscarinic antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:65191 | atypical antipsychotic agent |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Mixed bipolar I disorder | indication | 16506000 | DOID:3312 |
Schizophrenia | indication | 58214004 | DOID:5419 |
Bipolar disorder in remission | indication | 85248005 | |
Bipolar affective disorder, current episode manic | indication | 191618007 | |
Bipolar affective disorder, current episode depression | indication | 191627008 | DOID:3312 |
Major depressive disorder | indication | 370143000 | |
Depression Treatment Adjunct | indication | ||
Agitation associated with Bipolar Mania | indication | ||
Agitation associated with Schizophrenia | indication | ||
Nausea and vomiting | off-label use | 16932000 | |
Feeling agitated | off-label use | 24199005 | |
Migraine | off-label use | 37796009 | DOID:6364 |
Insomnia | off-label use | 193462001 | |
Anxiety disorder | off-label use | 197480006 | DOID:2030 |
Chemotherapy-induced nausea and vomiting | off-label use | 236084000 | |
cannabinoid hyperememsis | off-label use | 11047881000119100 | |
cannabinoid hyperememsis | off-label use | 11048011000119100 | |
Delirium | contraindication | 2776000 | |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Sinus tachycardia | contraindication | 11092001 | |
Hypercholesterolemia | contraindication | 13644009 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Abnormal sexual function | contraindication | 56925008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Sedation | contraindication | 72641008 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Heart failure | contraindication | 84114007 | DOID:6000 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Hyponatremia | contraindication | 89627008 | |
Tardive dyskinesia | contraindication | 102449007 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Transient ischemic attack | contraindication | 266257000 | DOID:224 |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.59 | Basic |
pKa2 | 5.72 | Basic |
pKa3 | 0.66 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11185541 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11241425 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11185541 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11241425 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11185541 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11241425 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10300054 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 10716785 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11185541 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 11241425 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9126977 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 9517235 | Aug. 23, 2031 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCTION OF THE ADVERSE METABOLIC PROFILE |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING BIPOLAR DISORDER BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | 8778960 | Feb. 13, 2032 | METHOD OF TREATING SCHIZOPHRENIA BY ADMINISTERING THE ATYPICAL ANTIPSYCHOTIC OLANZAPINE AND SAMIDORPHAN, WITH REDUCED ANTIPSYCHOTIC INDUCED WEIGHT GAIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | May 28, 2026 | NEW CHEMICAL ENTITY |
15MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | May 28, 2026 | NEW CHEMICAL ENTITY |
20MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | May 28, 2026 | NEW CHEMICAL ENTITY |
5MG;EQ 10MG BASE | LYBALVI | ALKERMES INC | N213378 | May 28, 2021 | RX | TABLET | ORAL | May 28, 2026 | NEW CHEMICAL ENTITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.32 | WOMBAT-PK | CHEMBL | |||
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.52 | WOMBAT-PK | CHEMBL | |||
Beta-1 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.40 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.49 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.74 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 6.26 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 5.90 | CHEMBL | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.92 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.96 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 8.10 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.98 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 7.72 | WOMBAT-PK | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.09 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.10 | WOMBAT-PK | ||||
D(1B) dopamine receptor | GPCR | Ki | 7.05 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 8.16 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 7.36 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.51 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.10 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.14 | WOMBAT-PK | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.22 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.23 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 6.12 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 7.54 | WOMBAT-PK | |||||
D(4) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.80 | WOMBAT-PK | ||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.59 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 6.70 | WOMBAT-PK | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.58 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 5A | GPCR | Ki | 5.92 | PDSP | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 6.51 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 1E | GPCR | AGONIST | Ki | 5.70 | IUPHAR | ||||
FAD-linked sulfhydryl oxidase ALR | Enzyme | AC50 | 6.43 | CHEMBL | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.68 | WOMBAT-PK | |||||
Histone H1.0 | Nuclear other | Ki | 8.70 | CHEMBL | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 8.05 | WOMBAT-PK | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.56 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.68 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.36 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 7.19 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 8.20 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.66 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 7.90 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.21 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.40 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.02 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | ANTAGONIST | Ki | 7 | IUPHAR | ||||
D(1A) dopamine receptor | GPCR | Ki | 7.70 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 9.52 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 7.41 | CHEMBL | |||||
D(4) dopamine receptor | GPCR | Ki | 7.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 8.60 | IUPHAR | ||||
Transporter | Transporter | Ki | 5.70 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.54 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 7.92 | CHEMBL |
ID | Source |
---|---|
4020996 | VUID |
N0000148465 | NUI |
D00454 | KEGG_DRUG |
221373-18-8 | SECONDARY_CAS_RN |
4020996 | VANDF |
C0171023 | UMLSCUI |
CHEBI:7735 | CHEBI |
CHEMBL715 | ChEMBL_ID |
CHEMBL1201741 | ChEMBL_ID |
CHEMBL3989694 | ChEMBL_ID |
DB00334 | DRUGBANK_ID |
D000077152 | MESH_DESCRIPTOR_UI |
135398745 | PUBCHEM_CID |
47 | IUPHAR_LIGAND_ID |
6956 | INN_ID |
N7U69T4SZR | UNII |
1294588 | RXNORM |
169390 | MMSL |
172501 | MMSL |
5198 | MMSL |
6063 | MMSL |
d04050 | MMSL |
006204 | NDDF |
013309 | NDDF |
108441004 | SNOMEDCT_US |
386849001 | SNOMEDCT_US |
725800004 | SNOMEDCT_US |
735189005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3230 | CAPSULE | 3 mg | ORAL | NDA | 34 sections |
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3231 | CAPSULE | 6 mg | ORAL | NDA | 34 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4112 | TABLET | 2.50 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4112 | TABLET | 2.50 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4115 | TABLET | 5 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4115 | TABLET | 5 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4116 | TABLET | 7.50 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4116 | TABLET | 7.50 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4117 | TABLET | 10 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4117 | TABLET | 10 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4415 | TABLET | 15 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4415 | TABLET | 15 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4420 | TABLET | 20 mg | ORAL | NDA | 36 sections |
Zyprexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4420 | TABLET | 20 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4453 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4453 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4454 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4454 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4455 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4455 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4456 | TABLET, ORALLY DISINTEGRATING | 20 mg | ORAL | NDA | 36 sections |
ZYPREXA Zydis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-4456 | TABLET, ORALLY DISINTEGRATING | 20 mg | ORAL | NDA | 36 sections |
ZYPREXA Intramuscular | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-7597 | INJECTION, POWDER, FOR SOLUTION | 10 mg | INTRAMUSCULAR | NDA | 36 sections |
ZYPREXA Intramuscular | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-7597 | INJECTION, POWDER, FOR SOLUTION | 10 mg | INTRAMUSCULAR | NDA | 36 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5245 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 31 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5245 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 31 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5246 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 31 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5246 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 31 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5247 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | ANDA | 31 sections |
Olanzapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5247 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | ANDA | 31 sections |