clozapine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 4107.82 15.82 2077 82646 72923 56134421
Neutropenia 3673.70 15.82 2511 82212 155656 56051688
Granulocytopenia 2993.30 15.82 822 83901 4522 56202822
Neutrophil count increased 2775.81 15.82 988 83735 13977 56193367
Schizophrenia 2709.93 15.82 888 83835 9611 56197733
Neutrophilia 2516.46 15.82 672 84051 3261 56204083
White blood cell count increased 2333.81 15.82 1201 83522 43558 56163786
Death 2226.47 15.82 2643 82080 338783 55868561
Antipsychotic drug level increased 1701.29 15.82 474 84249 2768 56204576
Psychotic disorder 1226.10 15.82 632 84091 22926 56184418
Salivary hypersecretion 1169.77 15.82 429 84294 6621 56200723
Neutrophil count decreased 979.26 15.82 717 84006 49105 56158239
White blood cell count decreased 977.47 15.82 1071 83652 124919 56082425
Differential white blood cell count abnormal 904.43 15.82 212 84511 520 56206824
Sedation 887.19 15.82 588 84135 34266 56173078
Mental impairment 884.74 15.82 416 84307 12306 56195038
Agranulocytosis 829.89 15.82 482 84241 22177 56185167
Leukopenia 702.60 15.82 688 84035 70252 56137092
Myocarditis 682.39 15.82 311 84412 8547 56198797
Pain 611.75 15.82 128 84595 663056 55544288
Anosognosia 579.58 15.82 191 84532 2098 56205246
Platelet count increased 555.17 15.82 328 84395 15570 56191774
Rheumatoid arthritis 553.90 15.82 4 84719 382600 55824744
Treatment noncompliance 527.11 15.82 418 84305 32205 56175139
Blood prolactin abnormal 524.82 15.82 176 84547 2049 56205295
Arthralgia 523.74 15.82 69 84654 501600 55705744
Dystonia 515.99 15.82 287 84436 12134 56195210
Disturbance in social behaviour 504.15 15.82 185 84538 2856 56204488
Rash 471.13 15.82 87 84636 492960 55714384
Sexual dysfunction 463.22 15.82 179 84544 3209 56204135
Dyskinesia 461.76 15.82 369 84354 28739 56178605
Drug level increased 459.03 15.82 321 84402 20404 56186940
Fatigue 451.87 15.82 320 84403 788232 55419112
Schizoaffective disorder 450.69 15.82 169 84554 2780 56204564
Metabolic disorder 440.43 15.82 198 84525 5263 56202081
Hallucination, auditory 437.39 15.82 251 84472 11273 56196071
Electrocardiogram QT prolonged 429.28 15.82 468 84255 54120 56153224
Headache 426.99 15.82 155 84568 558889 55648455
Mental disorder 414.99 15.82 318 84405 23286 56184058
Antipsychotic drug level above therapeutic 411.29 15.82 121 84602 880 56206464
Nausea 409.62 15.82 332 84391 763846 55443498
Neuroleptic malignant syndrome 403.84 15.82 238 84485 11240 56196104
Suicide attempt 398.69 15.82 463 84260 57373 56149971
Delusion 390.52 15.82 231 84492 10984 56196360
Pruritus 364.76 15.82 30 84693 316593 55890751
Personality change 358.07 15.82 175 84548 5642 56201702
Alopecia 357.75 15.82 21 84702 293437 55913907
Tachycardia 357.33 15.82 601 84122 105275 56102069
Leukocytosis 334.08 15.82 281 84442 23510 56183834
Haemoglobin decreased 326.12 15.82 661 84062 133476 56073868
Joint swelling 324.17 15.82 31 84692 289769 55917575
Catatonia 320.54 15.82 144 84579 3820 56203524
Diarrhoea 300.51 15.82 312 84411 638195 55569149
Abdominal discomfort 289.11 15.82 38 84685 277236 55930108
Drug hypersensitivity 286.27 15.82 38 84685 275167 55932177
Swelling 280.83 15.82 21 84702 239750 55967594
Antipsychotic drug level decreased 280.36 15.82 70 84653 244 56207100
Eosinophil count decreased 270.04 15.82 102 84621 1713 56205631
Psychiatric decompensation 265.49 15.82 93 84630 1245 56206099
Peripheral swelling 262.71 15.82 25 84698 234701 55972643
Drug interaction 260.96 15.82 800 83923 208955 55998389
Drug intolerance 256.15 15.82 45 84678 264773 55942571
Pain in extremity 246.76 15.82 71 84652 297360 55909984
Arthropathy 244.94 15.82 14 84709 200261 56007083
Overdose 242.35 15.82 509 84214 105321 56102023
Sinusitis 241.06 15.82 14 84709 197567 56009777
Hypersensitivity 236.46 15.82 49 84674 256359 55950985
Sinus tachycardia 231.86 15.82 223 84500 22221 56185123
C-reactive protein increased 226.88 15.82 417 84306 78267 56129077
Systemic lupus erythematosus 218.94 15.82 13 84710 180065 56027279
Troponin increased 217.85 15.82 145 84578 8490 56198854
Somnolence 208.46 15.82 629 84094 162784 56044560
Pre-existing disease 204.12 15.82 49 84674 138 56207206
Extrapyramidal disorder 179.76 15.82 149 84574 12207 56195137
Therapeutic product effect decreased 179.45 15.82 22 84701 169430 56037914
Paranoia 176.29 15.82 139 84584 10605 56196739
Back pain 175.04 15.82 69 84654 237101 55970243
Urticaria 174.16 15.82 11 84712 144665 56062679
Antipsychotic drug level below therapeutic 172.89 15.82 47 84676 246 56207098
Nasopharyngitis 171.97 15.82 59 84664 220900 55986444
Dyspnoea 165.40 15.82 409 84314 592168 55615176
Mean cell haemoglobin decreased 165.26 15.82 95 84628 4277 56203067
Agitation 162.76 15.82 298 84425 55738 56151606
Lung neoplasm malignant 161.37 15.82 163 84560 17233 56190111
Injection site pain 161.23 15.82 3 84720 117115 56090229
Stomatitis 159.04 15.82 5 84718 120805 56086539
Treatment failure 158.15 15.82 32 84691 170360 56036984
Chronic obstructive pulmonary disease 157.59 15.82 298 84425 57117 56150227
Eosinophil count increased 156.66 15.82 124 84599 9513 56197831
Discomfort 153.58 15.82 17 84706 141744 56065600
Aggression 152.90 15.82 177 84546 21829 56185515
Living in residential institution 152.14 15.82 48 84675 453 56206891
Wound 152.02 15.82 16 84707 138788 56068556
Refusal of examination 148.18 15.82 37 84686 129 56207215
Blood glucose increased 144.32 15.82 337 84386 74814 56132530
Monocyte count increased 143.50 15.82 99 84624 6149 56201195
Erythema 141.19 15.82 31 84692 155908 56051436
Drug ineffective 140.61 15.82 812 83911 918177 55289167
Akathisia 139.94 15.82 111 84612 8541 56198803
Blister 138.19 15.82 6 84717 108881 56098463
Neoplasm malignant 135.87 15.82 185 84538 26870 56180474
Lymphocyte count increased 133.74 15.82 74 84649 3093 56204251
Pleurothotonus 132.94 15.82 56 84667 1265 56206079
On and off phenomenon 131.31 15.82 59 84664 1565 56205779
Abdominal pain upper 129.68 15.82 53 84670 178260 56029084
Drooling 129.61 15.82 75 84648 3419 56203925
Psychotic symptom 127.72 15.82 55 84668 1314 56206030
Aspiration 125.56 15.82 109 84614 9512 56197832
Lymphocyte count decreased 125.36 15.82 181 84542 27758 56179586
Mean cell haemoglobin concentration decreased 124.41 15.82 71 84652 3152 56204192
Abnormal behaviour 124.29 15.82 153 84570 20119 56187225
General physical condition abnormal 122.99 15.82 75 84648 3768 56203576
Eosinophilia 122.24 15.82 151 84572 19926 56187418
Mean cell volume decreased 122.19 15.82 72 84651 3396 56203948
Hypoaesthesia 118.61 15.82 33 84690 141458 56065886
Electroencephalogram abnormal 118.24 15.82 71 84652 3468 56203876
Intestinal obstruction 117.97 15.82 176 84547 27795 56179549
Impaired healing 116.47 15.82 3 84720 86838 56120506
Hyperprolactinaemia 116.02 15.82 71 84652 3590 56203754
Terminal state 115.47 15.82 59 84664 2094 56205250
Hallucination 115.43 15.82 239 84484 48910 56158434
Coronavirus infection 114.38 15.82 68 84655 3261 56204083
Hepatic enzyme increased 113.63 15.82 58 84665 171326 56036018
Delirium 113.35 15.82 218 84505 42299 56165045
Neuropathy peripheral 112.29 15.82 12 84711 102881 56104463
Blood prolactin increased 112.15 15.82 67 84656 3242 56204102
Faecaloma 110.88 15.82 91 84632 7350 56199994
Contraindicated product administered 110.75 15.82 72 84651 186214 56021130
Pneumonia aspiration 110.50 15.82 185 84538 32226 56175118
Cough 109.83 15.82 138 84585 259823 55947521
Suicidal ideation 109.82 15.82 258 84465 57484 56149860
Muscle rigidity 108.26 15.82 105 84618 10566 56196778
Choking 107.57 15.82 97 84626 8900 56198444
Neutrophil count abnormal 106.24 15.82 60 84663 2610 56204734
Haemoglobin increased 104.22 15.82 64 84659 3256 56204088
Asthenia 104.03 15.82 226 84497 342747 55864597
Disease progression 103.48 15.82 17 84706 105156 56102188
Psoriasis 103.25 15.82 10 84713 92682 56114662
Obsessive-compulsive disorder 102.68 15.82 66 84657 3640 56203704
Urinary incontinence 99.70 15.82 168 84555 29417 56177927
Dementia 99.59 15.82 126 84597 17032 56190312
Paraesthesia 99.50 15.82 36 84687 130478 56076866
Haematocrit decreased 97.14 15.82 188 84535 36641 56170703
Generalised tonic-clonic seizure 96.19 15.82 159 84564 27407 56179937
COVID-19 94.68 15.82 288 84435 74770 56132574
Troponin T increased 94.46 15.82 41 84682 999 56206345
Intentional self-injury 93.80 15.82 149 84574 24843 56182501
Breast cancer 92.64 15.82 218 84505 48615 56158729
Musculoskeletal pain 92.41 15.82 8 84715 81144 56126200
Orthostatic hypotension 91.91 15.82 173 84550 33026 56174318
Psychiatric symptom 91.15 15.82 68 84655 4776 56202568
Blood creatine phosphokinase increased 90.59 15.82 156 84567 27796 56179548
Metabolic syndrome 89.01 15.82 43 84680 1350 56205994
Arthritis 88.05 15.82 21 84702 99831 56107513
Migraine 87.72 15.82 13 84710 86784 56120560
Malignant neoplasm progression 87.32 15.82 6 84717 73581 56133763
Contusion 87.32 15.82 42 84681 128388 56078956
Acute psychosis 86.75 15.82 50 84673 2262 56205082
Wrong patient received product 84.26 15.82 48 84675 2123 56205221
Myalgia 84.08 15.82 47 84676 131978 56075366
Circulatory collapse 83.60 15.82 128 84595 20675 56186669
Sopor 83.05 15.82 128 84595 20794 56186550
Diabetes mellitus 82.76 15.82 219 84504 52516 56154828
Myoclonus 82.52 15.82 108 84615 15095 56192249
Pericardial effusion 80.75 15.82 146 84577 27029 56180315
Febrile neutropenia 80.63 15.82 29 84694 105516 56101828
Muscle spasms 80.39 15.82 54 84669 137317 56070027
Decreased appetite 80.05 15.82 129 84594 219102 55988242
Stoma site discharge 79.80 15.82 40 84683 1362 56205982
Tardive dyskinesia 77.69 15.82 77 84646 7954 56199390
Off label use 77.53 15.82 505 84218 555675 55651669
Polyserositis 77.41 15.82 26 84697 304 56207040
Irritable bowel syndrome 77.26 15.82 7 84716 68451 56138893
Flushing 76.93 15.82 8 84715 70092 56137252
Intentional product use issue 76.88 15.82 27 84696 99706 56107638
Fibromyalgia 76.56 15.82 3 84720 59600 56147744
Pneumonia 76.52 15.82 942 83781 406156 55801188
Maternal exposure during pregnancy 75.53 15.82 105 84618 189448 56017896
Lung cancer metastatic 73.95 15.82 46 84677 2395 56204949
Oculogyric crisis 73.80 15.82 39 84684 1485 56205859
Mean cell volume increased 71.90 15.82 50 84673 3145 56204199
Red blood cell count decreased 71.12 15.82 165 84558 36452 56170892
Parkinsonism 70.05 15.82 79 84644 9467 56197877
Insurance issue 68.62 15.82 52 84671 3740 56203604
Malaise 68.57 15.82 850 83873 367010 55840334
Constipation 67.84 15.82 528 84195 201415 56005929
Epistaxis 67.81 15.82 10 84713 67013 56140331
Electrocardiogram abnormal 67.76 15.82 72 84651 8072 56199272
Osteoarthritis 66.76 15.82 19 84704 80277 56127067
Enuresis 65.92 15.82 42 84681 2281 56205063
Lower respiratory tract infection 65.85 15.82 344 84379 114450 56092894
Schizoaffective disorder bipolar type 65.70 15.82 19 84704 129 56207215
Platelet count decreased 65.36 15.82 325 84398 106058 56101286
Oedema peripheral 65.13 15.82 98 84625 171156 56036188
Gastrointestinal disorder 65.00 15.82 45 84678 112657 56094687
Mutism 64.70 15.82 35 84688 1398 56205946
Monocyte count decreased 64.65 15.82 39 84684 1921 56205423
Toxicity to various agents 64.64 15.82 567 84156 223997 55983347
Mania 64.34 15.82 83 84640 11437 56195907
Intentional overdose 64.23 15.82 237 84486 67880 56139464
Electrocardiogram T wave abnormal 64.04 15.82 41 84682 2245 56205099
Ileus paralytic 63.97 15.82 52 84671 4143 56203201
Stoma site erythema 63.36 15.82 31 84692 1001 56206343
Rash pruritic 63.25 15.82 4 84719 52590 56154754
Posture abnormal 63.02 15.82 40 84683 2158 56205186
Nasal congestion 62.98 15.82 6 84717 56364 56150980
Refusal of treatment by patient 62.62 15.82 56 84667 5082 56202262
Gastrointestinal hypomotility 61.94 15.82 30 84693 947 56206397
Anaphylactic reaction 61.58 15.82 8 84715 58987 56148357
Blood alkaline phosphatase increased 61.37 15.82 162 84561 38783 56168561
Red cell distribution width increased 61.33 15.82 73 84650 9267 56198077
Haematocrit increased 61.26 15.82 39 84684 2115 56205229
Herpes zoster 61.19 15.82 19 84704 75870 56131474
Freezing phenomenon 61.04 15.82 31 84692 1086 56206258
Medication error 60.61 15.82 170 84553 42165 56165179
Impaired self-care 60.29 15.82 36 84687 1740 56205604
Muscle injury 60.25 15.82 5 84718 52495 56154849
Wrong product administered 59.78 15.82 57 84666 5615 56201729
Musculoskeletal stiffness 59.59 15.82 89 84634 155918 56051426
Sinus rhythm 59.10 15.82 26 84697 655 56206689
Chest discomfort 58.99 15.82 38 84685 98819 56108525
Stoma site irritation 57.78 15.82 19 84704 207 56207137
Blood urea decreased 57.21 15.82 38 84685 2216 56205128
Ileus 55.19 15.82 85 84638 13797 56193547
Sudden death 54.78 15.82 70 84653 9555 56197789
Loss of personal independence in daily activities 54.70 15.82 27 84696 81342 56126002
Electrocardiogram T wave inversion 54.30 15.82 43 84680 3300 56204044
Bradykinesia 53.49 15.82 50 84673 4804 56202540
Gastrointestinal carcinoma 53.19 15.82 34 84689 1857 56205487
Mucosal inflammation 52.25 15.82 3 84720 42807 56164537
Hot flush 52.13 15.82 5 84718 46721 56160623
Plasma cell myeloma 52.02 15.82 5 84718 46641 56160703
Visual impairment 50.82 15.82 24 84699 74178 56133166
Acute kidney injury 50.52 15.82 189 84534 240574 55966770
Epilepsy 50.43 15.82 115 84608 25116 56182228
Cardiomyopathy 50.41 15.82 89 84634 16169 56191175
Dry skin 50.11 15.82 6 84717 47103 56160241
Night sweats 49.96 15.82 3 84720 41210 56166134
Urinary tract infection 49.68 15.82 567 84156 239946 55967398
Blood pressure increased 49.66 15.82 89 84634 145087 56062257
Multiple sclerosis relapse 49.59 15.82 5 84718 44898 56162446
Benign ethnic neutropenia 49.50 15.82 9 84714 0 56207344
Bronchitis 49.07 15.82 58 84665 112253 56095091
Dyspepsia 48.56 15.82 33 84690 83438 56123906
Oedema 48.18 15.82 32 84691 81888 56125456
Weight decreased 47.92 15.82 193 84530 240521 55966823
Hyperkinesia 47.42 15.82 30 84693 1609 56205735
Hypertension 47.29 15.82 198 84525 244080 55963264
Loss of consciousness 47.24 15.82 304 84419 109045 56098299
Neck pain 46.85 15.82 17 84706 61538 56145806
Psychiatric evaluation 46.27 15.82 10 84713 14 56207330
Chills 45.89 15.82 52 84671 102552 56104792
Haematochezia 45.45 15.82 6 84717 43712 56163632
Hypokalaemia 45.44 15.82 45 84678 94392 56112952
Pancreatic fibrosis 45.37 15.82 13 84710 85 56207259
Dyspnoea exertional 45.35 15.82 13 84710 54676 56152668
Product use issue 45.19 15.82 137 84586 185904 56021440
Borderline personality disorder 45.06 15.82 22 84701 707 56206637
Parkinson's disease 44.99 15.82 27 84696 1317 56206027
Hypothermia 44.94 15.82 73 84650 12397 56194947
Inappropriate schedule of product administration 44.59 15.82 36 84687 83351 56123993
Overweight 44.16 15.82 38 84685 3276 56204068
Wheezing 43.20 15.82 30 84693 74996 56132348
Thrombosis 42.61 15.82 18 84705 59409 56147935
Osteoporosis 42.02 15.82 13 84710 52039 56155305
Body temperature increased 41.86 15.82 130 84593 34112 56173232
Persecutory delusion 41.62 15.82 33 84690 2537 56204807
Vomiting 41.32 15.82 516 84207 497712 55709632
Megacolon 40.81 15.82 28 84695 1723 56205621
Negativism 40.27 15.82 17 84706 386 56206958
Rebound psychosis 40.02 15.82 10 84713 35 56207309
Foreign body in gastrointestinal tract 39.80 15.82 10 84713 36 56207308
Cardiac arrest 39.79 15.82 244 84479 86070 56121274
Interstitial lung disease 39.78 15.82 18 84705 57045 56150299
Abdominal pain 39.56 15.82 228 84495 258577 55948767
Dysgeusia 39.38 15.82 7 84716 40908 56166436
Myocardial fibrosis 39.16 15.82 20 84703 709 56206635
Cervix neoplasm 39.07 15.82 14 84709 201 56207143
Dizziness 38.98 15.82 370 84353 375770 55831574
Suicidal behaviour 38.88 15.82 31 84692 2402 56204942
Coma 38.58 15.82 185 84538 59470 56147874
Stoma site pain 38.45 15.82 21 84702 855 56206489
Fibroma 38.42 15.82 20 84703 738 56206606
Imprisonment 38.21 15.82 14 84709 215 56207129
Pain in jaw 38.20 15.82 7 84716 40029 56167315
Serositis 38.07 15.82 19 84704 641 56206703
Red blood cell count increased 37.99 15.82 33 84690 2881 56204463
Dysarthria 37.60 15.82 138 84585 39412 56167932
Tobacco interaction 37.58 15.82 9 84714 25 56207319
Akinesia 36.84 15.82 25 84698 1511 56205833
Bipolar disorder 36.79 15.82 51 84672 7529 56199815
Rhinorrhoea 36.73 15.82 20 84703 57017 56150327
Hallucination, visual 36.45 15.82 81 84642 17387 56189957
Cardiac steatosis 36.35 15.82 9 84714 30 56207314
Skin ulcer 36.31 15.82 7 84716 38601 56168743
Electroconvulsive therapy 36.07 15.82 10 84713 57 56207287
Bundle branch block right 36.05 15.82 40 84683 4707 56202637
Cataract 35.99 15.82 16 84707 51231 56156113
Therapy cessation 35.66 15.82 106 84617 27158 56180186
Central obesity 35.65 15.82 22 84701 1129 56206215
Monocytosis 35.48 15.82 15 84708 342 56207002
Seizure 35.47 15.82 315 84408 124804 56082540
Metastatic neoplasm 35.07 15.82 36 84687 3877 56203467
Insomnia 34.99 15.82 159 84564 191701 56015643
Fluid retention 34.77 15.82 19 84704 54059 56153285
Device expulsion 34.66 15.82 3 84720 30446 56176898
Social avoidant behaviour 34.59 15.82 31 84692 2821 56204523
Gamma-glutamyltransferase increased 34.52 15.82 114 84609 30891 56176453
Burning sensation 34.52 15.82 15 84708 48681 56158663
Feeling abnormal 34.17 15.82 96 84627 133506 56073838
Ankle fracture 34.16 15.82 76 84647 16327 56191017
Angioedema 34.10 15.82 10 84713 41443 56165901
Muscular weakness 33.97 15.82 66 84657 104386 56102958
Ill-defined disorder 33.73 15.82 32 84691 68511 56138833
Parkinsonism hyperpyrexia syndrome 32.95 15.82 11 84712 126 56207218
Eye pain 32.63 15.82 4 84719 30843 56176501
Intestinal strangulation 32.52 15.82 10 84713 86 56207258
Gastrooesophageal reflux disease 32.25 15.82 47 84676 83210 56124134
Depressed level of consciousness 32.25 15.82 169 84554 56264 56151080
Intestinal pseudo-obstruction 31.95 15.82 18 84705 779 56206565
Drug monitoring procedure incorrectly performed 31.83 15.82 11 84712 141 56207203
Ovarian cancer 31.83 15.82 43 84680 6195 56201149
Granulocytosis 31.66 15.82 9 84714 57 56207287
Lethargy 31.46 15.82 157 84566 51284 56156060
Hepatitis C 30.80 15.82 40 84683 5546 56201798
Eye movement disorder 30.74 15.82 37 84686 4752 56202592
International normalised ratio increased 30.53 15.82 14 84709 44027 56163317
Dry eye 30.53 15.82 8 84715 35708 56171636
Blood bilirubin decreased 30.49 15.82 17 84706 721 56206623
Abnormal clotting factor 30.16 15.82 10 84713 112 56207232
Obesity 30.05 15.82 88 84635 22360 56184984
Product administration error 29.91 15.82 84 84639 20845 56186499
Pseudophaeochromocytoma 29.73 15.82 9 84714 73 56207271
Liver injury 29.49 15.82 13 84710 41835 56165509
Blood albumin decreased 29.35 15.82 64 84659 13564 56193780
Affective disorder 29.16 15.82 39 84684 5564 56201780
Product dispensing error 29.09 15.82 51 84672 9213 56198131
Myocardial infarction 29.04 15.82 239 84484 92631 56114713
Influenza B virus test positive 28.95 15.82 12 84711 260 56207084
Oral pain 28.84 15.82 3 84720 26290 56181054
Atrial fibrillation 28.77 15.82 77 84646 108820 56098524
Waxy flexibility 28.67 15.82 10 84713 132 56207212
Arteriosclerosis coronary artery 28.55 15.82 46 84677 7759 56199585
Toxicologic test abnormal 28.50 15.82 16 84707 688 56206656
Sciatica 28.45 15.82 3 84720 26007 56181337
Chemotherapy 28.41 15.82 21 84702 1454 56205890
Dysphemia 28.38 15.82 26 84697 2434 56204910
Condition aggravated 28.23 15.82 358 84365 344540 55862804
Grandiosity 27.93 15.82 12 84711 285 56207059
Cystitis 27.71 15.82 20 84703 49018 56158326
Joint range of motion decreased 27.55 15.82 3 84720 25362 56181982
Neutrophil count normal 27.50 15.82 5 84718 0 56207344
Parotitis 27.48 15.82 20 84703 1352 56205992
Self-injurious ideation 27.43 15.82 25 84698 2325 56205019
Visceral congestion 27.36 15.82 12 84711 300 56207044
Basal cell carcinoma 27.35 15.82 3 84720 25218 56182126
Hip arthroplasty 27.21 15.82 12 84711 38611 56168733
Palliative care 27.21 15.82 13 84710 398 56206946
Hyperkalaemia 27.14 15.82 22 84701 50843 56156501
Rash erythematous 27.13 15.82 11 84712 37210 56170134
Diverticulitis 27.11 15.82 10 84713 35842 56171502
Hepatic steatosis 27.08 15.82 94 84629 26120 56181224
Body mass index increased 26.79 15.82 18 84705 1070 56206274
Swelling face 26.64 15.82 27 84696 56042 56151302
Hepatotoxicity 26.58 15.82 7 84716 31146 56176198
Troponin abnormal 26.53 15.82 7 84716 32 56207312
Microcytosis 26.47 15.82 10 84713 168 56207176
Echocardiogram abnormal 26.45 15.82 19 84704 1258 56206086
Colitis ulcerative 26.20 15.82 3 84720 24388 56182956
Intestinal dilatation 26.09 15.82 20 84703 1463 56205881
Accidental exposure to product 26.00 15.82 89 84634 24558 56182786
Eosinopenia 25.69 15.82 7 84716 37 56207307
Productive cough 25.68 15.82 28 84695 56204 56151140
Rash maculo-papular 25.63 15.82 6 84717 28901 56178443
Liver function test abnormal 25.57 15.82 136 84587 45535 56161809
Swollen tongue 25.52 15.82 7 84716 30317 56177027
Product quality issue 25.48 15.82 8 84715 31728 56175616
Hypocalcaemia 25.44 15.82 6 84717 28754 56178590
Psychotic behaviour 25.32 15.82 14 84709 584 56206760
Neuralgia 25.24 15.82 3 84720 23692 56183652
Dysphonia 25.18 15.82 16 84707 41931 56165413
Skin exfoliation 25.16 15.82 12 84711 36888 56170456
Globulin abnormal 25.16 15.82 5 84718 3 56207341
Upper respiratory tract infection 25 15.82 43 84680 71245 56136099
Confusional state 24.92 15.82 446 84277 207709 55999635
Dementia with Lewy bodies 24.79 15.82 11 84712 283 56207061
Obsessive-compulsive symptom 24.68 15.82 8 84715 83 56207261
Liver function test increased 24.63 15.82 6 84717 28127 56179217
Osteonecrosis 24.58 15.82 3 84720 23212 56184132
Nephrolithiasis 24.17 15.82 13 84710 37322 56170022
Vision blurred 23.97 15.82 56 84667 82887 56124457
Unresponsive to stimuli 23.95 15.82 103 84620 31622 56175722
Blood phosphorus increased 23.91 15.82 25 84698 2751 56204593
Stevens-Johnson syndrome 23.82 15.82 3 84720 22660 56184684
Asphyxia 23.79 15.82 36 84687 5753 56201591
Stoma site reaction 23.73 15.82 10 84713 226 56207118
Impulsive behaviour 23.65 15.82 19 84704 1488 56205856
Parotid gland enlargement 23.63 15.82 15 84708 809 56206535
Joint stiffness 23.43 15.82 12 84711 35413 56171931
Psychomotor hyperactivity 23.33 15.82 48 84675 9772 56197572
Mental status changes 23.31 15.82 115 84608 37386 56169958
Basophil count increased 23.16 15.82 15 84708 838 56206506
Blood triglycerides increased 23.09 15.82 53 84670 11624 56195720
Thrombocytosis 22.97 15.82 34 84689 5328 56202016
Vertigo 22.96 15.82 29 84694 54543 56152801
Suspiciousness 22.87 15.82 11 84712 342 56207002
Ataxia 22.77 15.82 60 84663 14343 56193001
Apathy 22.69 15.82 42 84681 7912 56199432
Subileus 22.69 15.82 25 84698 2919 56204425
Incoherent 22.66 15.82 30 84693 4239 56203105
Echolalia 22.66 15.82 9 84714 174 56207170
Cardiac disorder 22.59 15.82 132 84591 45755 56161589
Haematoma 22.47 15.82 10 84713 32009 56175335
Neoplasm progression 22.47 15.82 10 84713 32006 56175338
Activated partial thromboplastin time abnormal 22.44 15.82 8 84715 113 56207231
Wrong technique in product usage process 22.37 15.82 33 84690 58135 56149209
Skin discolouration 22.19 15.82 12 84711 34344 56173000
Fungal infection 22.09 15.82 11 84712 32982 56174362
Eye swelling 22.06 15.82 3 84720 21373 56185971
Catecholamines urine increased 22.00 15.82 4 84719 0 56207344
Huntington's disease 22.00 15.82 4 84719 0 56207344
Pulmonary valve incompetence 21.90 15.82 17 84706 1267 56206077
Neutrophil percentage increased 21.85 15.82 24 84699 2792 56204552
Bradycardia 21.65 15.82 43 84680 67461 56139883
Miosis 21.63 15.82 37 84686 6555 56200789
Neutrophil toxic granulation present 21.53 15.82 6 84717 35 56207309
Gastrointestinal haemorrhage 21.38 15.82 52 84671 75899 56131445
Laryngeal cancer stage III 21.12 15.82 5 84718 13 56207331
Body mass index decreased 21.10 15.82 11 84712 407 56206937
Stoma site inflammation 21.08 15.82 11 84712 408 56206936
Stupor 20.96 15.82 28 84695 3990 56203354
Heart rate decreased 20.93 15.82 18 84705 40409 56166935
Haemoptysis 20.79 15.82 7 84716 26553 56180791
Poverty of speech 20.78 15.82 10 84713 311 56207033
Polydipsia 20.77 15.82 25 84698 3210 56204134
Asterixis 20.70 15.82 16 84707 1185 56206159
Hypervolaemia 20.66 15.82 7 84716 26451 56180893
Poor personal hygiene 20.64 15.82 10 84713 316 56207028
Blood bicarbonate increased 20.54 15.82 13 84710 698 56206646
Metamyelocyte count increased 20.52 15.82 9 84714 225 56207119
Left ventricular hypertrophy 20.49 15.82 31 84692 4953 56202391
Nervousness 20.46 15.82 9 84714 29006 56178338
Incontinence 20.43 15.82 48 84675 10687 56196657
Lip swelling 20.43 15.82 7 84716 26265 56181079
Left ventricular dysfunction 20.37 15.82 49 84674 11074 56196270
Hallucinations, mixed 20.33 15.82 29 84694 4395 56202949
Cardiac failure congestive 20.29 15.82 66 84657 87654 56119690
Intervertebral disc protrusion 20.26 15.82 4 84719 21690 56185654
Blunted affect 20.23 15.82 9 84714 233 56207111
Persistent depressive disorder 20.11 15.82 14 84709 882 56206462
Personality change due to a general medical condition 19.96 15.82 7 84716 94 56207250
Nuchal rigidity 19.66 15.82 12 84711 604 56206740
Live birth 19.65 15.82 3 84720 19602 56187742
Ear pain 19.64 15.82 11 84712 30879 56176465
Personality disorder 19.62 15.82 31 84692 5142 56202202
Mean cell haemoglobin increased 19.58 15.82 21 84702 2379 56204965
Gastric disorder 19.48 15.82 13 84710 33197 56174147
Transferrin saturation decreased 19.32 15.82 12 84711 623 56206721
Brain neoplasm 19.30 15.82 27 84696 4019 56203325
Injury 19.30 15.82 38 84685 59813 56147531
Bladder trabeculation 19.27 15.82 6 84717 54 56207290
Therapeutic product effect variable 19.19 15.82 15 84708 1129 56206215
Cervix cancer metastatic 19.17 15.82 6 84717 55 56207289
Palpitations 19.12 15.82 81 84642 99591 56107753
Vascular encephalopathy 18.85 15.82 10 84713 384 56206960
Pericarditis 18.82 15.82 92 84631 108831 56098513
Appendicitis 18.80 15.82 37 84686 7295 56200049
Dehydration 18.72 15.82 151 84572 158674 56048670
Sexually inappropriate behaviour 18.61 15.82 7 84716 116 56207228
Galactorrhoea 18.59 15.82 26 84697 3869 56203475
Femur fracture 18.58 15.82 19 84704 39276 56168068
Localised infection 18.56 15.82 9 84714 27403 56179941
Alcohol poisoning 18.50 15.82 18 84705 1817 56205527
Disorientation 18.47 15.82 106 84617 36507 56170837
Cerebral haemorrhage 18.46 15.82 10 84713 28596 56178748
Thinking abnormal 18.43 15.82 44 84679 9897 56197447
C-reactive protein abnormal 18.33 15.82 17 84706 36792 56170552
Nodule 18.32 15.82 3 84720 18616 56188728
Illness anxiety disorder 18.19 15.82 7 84716 124 56207220
Depressed mood 18.16 15.82 105 84618 36254 56171090
Inflammation 18.12 15.82 49 84674 69022 56138322
Therapeutic product effect incomplete 18.06 15.82 90 84633 105941 56101403
Haematuria 18.06 15.82 9 84714 26978 56180366
Eczema eyelids 17.98 15.82 7 84716 128 56207216
Blood pressure systolic increased 17.92 15.82 21 84702 40815 56166529
Drug level above therapeutic 17.75 15.82 27 84696 4335 56203009
Gallbladder cholesterolosis 17.69 15.82 12 84711 725 56206619
Osteopenia 17.68 15.82 3 84720 18138 56189206
Disturbance in attention 17.60 15.82 96 84627 32444 56174900
Musculoskeletal chest pain 17.56 15.82 4 84719 19637 56187707
Acne 17.56 15.82 5 84718 21131 56186213
Physical assault 17.55 15.82 13 84710 903 56206441
Rectal haemorrhage 17.48 15.82 22 84701 41445 56165899
Hypochromasia 17.29 15.82 9 84714 332 56207012
Hyponatraemia 17.23 15.82 87 84636 102052 56105292
Suspected COVID-19 16.96 15.82 18 84705 2015 56205329
Electrocardiogram T wave amplitude decreased 16.95 15.82 9 84714 346 56206998
Hallucination, olfactory 16.86 15.82 8 84715 241 56207103
Hypophagia 16.86 15.82 87 84636 28789 56178555
Exposure during pregnancy 16.83 15.82 128 84595 136214 56071130
Device related infection 16.72 15.82 6 84717 21874 56185470
Wrong drug 16.70 15.82 7 84716 156 56207188
Troponin I increased 16.61 15.82 18 84705 2063 56205281
Glaucoma 16.60 15.82 3 84720 17326 56190018
Cardiopulmonary failure 16.56 15.82 23 84700 3402 56203942
Thyroxine free decreased 16.54 15.82 11 84712 643 56206701
Lymphocyte percentage increased 16.53 15.82 9 84714 364 56206980
Cholestasis 16.52 15.82 10 84713 26903 56180441
Skin lesion 16.52 15.82 11 84712 28124 56179220
Phobic avoidance 16.50 15.82 3 84720 0 56207344
Myelocyte present 16.50 15.82 3 84720 0 56207344
Foreign body ingestion 16.50 15.82 3 84720 0 56207344
Nothing by mouth order 16.50 15.82 3 84720 0 56207344
Haemoglobinopathy 16.50 15.82 3 84720 0 56207344
Quarantine 16.47 15.82 5 84718 41 56207303
Pulmonary embolism 16.35 15.82 239 84484 106885 56100459
Eosinophilic myocarditis 16.31 15.82 9 84714 374 56206970
Foreign body 16.22 15.82 18 84705 2118 56205226
Appendicitis perforated 16.21 15.82 16 84707 1644 56205700
Neglect of personal appearance 16.21 15.82 6 84717 95 56207249
Limb discomfort 16.19 15.82 10 84713 26612 56180732
Faeces discoloured 16.15 15.82 3 84720 16993 56190351
Flatulence 16.12 15.82 14 84709 31274 56176070
Respiratory failure 16.08 15.82 216 84507 94846 56112498
Anxiety disorder 16.05 15.82 24 84699 3796 56203548
Thought blocking 16.03 15.82 6 84717 98 56207246
Speech disorder 16.03 15.82 104 84619 37389 56169955
Ischaemic stroke 15.95 15.82 3 84720 16839 56190505
Hypoglycaemia 15.87 15.82 38 84685 55777 56151567
Drug dependence 15.87 15.82 7 84716 22526 56184818
Metastases to spine 15.86 15.82 21 84702 2968 56204376

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 5901.71 14.88 3275 133202 46532 31514335
Neutrophil count increased 4518.14 14.88 1901 134576 13830 31547037
Schizophrenia 4437.68 14.88 1691 134786 9139 31551728
Neutropenia 4109.36 14.88 3949 132528 136415 31424452
White blood cell count increased 3828.03 14.88 2271 134206 36729 31524138
Granulocytopenia 3444.59 14.88 1207 135270 4892 31555975
Neutrophilia 3146.35 14.88 1006 135471 2837 31558030
Differential white blood cell count abnormal 2594.02 14.88 682 135795 631 31560236
Death 2001.47 14.88 4616 131861 355953 31204914
Antipsychotic drug level increased 1919.83 14.88 676 135801 2782 31558085
Myocarditis 1840.25 14.88 937 135540 10963 31549904
Psychotic disorder 1766.14 14.88 1134 135343 21159 31539708
Mental impairment 1524.62 14.88 768 135709 8764 31552103
Salivary hypersecretion 1437.52 14.88 692 135785 7100 31553767
Neutrophil count decreased 1420.74 14.88 1343 135134 45051 31515816
White blood cell count decreased 1377.47 14.88 1785 134692 85613 31475254
Agranulocytosis 1320.78 14.88 930 135547 20317 31540550
Neuroleptic malignant syndrome 928.41 14.88 686 135791 16183 31544684
Sedation 928.22 14.88 719 135758 18246 31542621
Tachycardia 857.60 14.88 1326 135151 74881 31485986
Treatment noncompliance 813.19 14.88 758 135719 24926 31535941
Leukopenia 672.37 14.88 1022 135455 56806 31504061
Platelet count increased 616.59 14.88 417 136060 8499 31552368
Antipsychotic drug level decreased 612.11 14.88 205 136272 697 31560170
Hallucination, auditory 582.70 14.88 427 136050 9933 31550934
Troponin increased 566.52 14.88 414 136063 9588 31551279
Mental disorder 558.98 14.88 469 136008 13365 31547502
Eosinophil count increased 557.00 14.88 372 136105 7419 31553448
Lower respiratory tract infection 509.31 14.88 618 135859 27619 31533248
Antipsychotic drug level below therapeutic 496.89 14.88 219 136258 1796 31559071
Rash 472.29 14.88 141 136336 201345 31359522
C-reactive protein increased 460.11 14.88 783 135694 47867 31513000
Acute kidney injury 459.13 14.88 323 136154 279391 31281476
Arthralgia 457.37 14.88 57 136420 151367 31409500
Diarrhoea 442.01 14.88 522 135955 351887 31208980
Fatigue 428.39 14.88 489 135988 334717 31226150
Antipsychotic drug level above therapeutic 414.87 14.88 165 136312 1012 31559855
Pruritus 414.69 14.88 33 136444 125134 31435733
Nausea 412.40 14.88 432 136045 307515 31253352
Pain 392.20 14.88 157 136320 186602 31374265
Leukocytosis 390.61 14.88 479 135998 21635 31539232
Catatonia 383.49 14.88 246 136231 4568 31556299
Delusion 381.27 14.88 355 136122 11642 31549225
Blood creatine phosphokinase increased 371.26 14.88 656 135821 41318 31519549
Eosinophil count decreased 346.69 14.88 145 136332 1030 31559837
Sinus tachycardia 339.39 14.88 379 136098 15470 31545397
Febrile neutropenia 335.33 14.88 60 136417 121789 31439078
Monocyte count increased 325.28 14.88 213 136264 4102 31556765
Headache 321.25 14.88 197 136280 183455 31377412
Faecaloma 317.66 14.88 216 136261 4440 31556427
Malignant neoplasm progression 302.54 14.88 8 136469 78990 31481877
Obsessive-compulsive disorder 294.67 14.88 211 136266 4726 31556141
Dyspnoea 292.14 14.88 656 135821 342823 31218044
Asthenia 289.62 14.88 325 136152 224430 31336437
Pain in extremity 283.66 14.88 75 136402 116128 31444739
Off label use 283.48 14.88 678 135799 346596 31214271
Malaise 278.67 14.88 1446 135031 167065 31393802
Haemoglobin decreased 265.14 14.88 1073 135404 111602 31449265
Psychiatric decompensation 257.86 14.88 139 136338 1837 31559030
Paranoia 240.84 14.88 261 136216 10294 31550573
Neuropathy peripheral 239.46 14.88 24 136453 75625 31485242
Decreased appetite 237.77 14.88 187 136290 153030 31407837
Atrial fibrillation 233.16 14.88 99 136378 113684 31447183
Aggression 231.23 14.88 502 135975 36789 31524078
Hyperkalaemia 230.84 14.88 11 136466 64340 31496527
Erythema 229.06 14.88 36 136441 80369 31480498
Lung neoplasm malignant 226.42 14.88 313 136164 15917 31544950
Disease progression 225.30 14.88 56 136421 90408 31470459
Peripheral swelling 224.31 14.88 18 136459 67847 31493020
Pneumonia aspiration 222.87 14.88 506 135971 38220 31522647
Oedema peripheral 222.78 14.88 97 136380 109742 31451125
Back pain 221.31 14.88 97 136380 109316 31451551
Lymphocyte count increased 212.77 14.88 141 136336 2772 31558095
Cardiomyopathy 211.34 14.88 294 136183 15039 31545828
Urticaria 209.02 14.88 9 136468 57508 31503359
Gastrointestinal hypomotility 204.87 14.88 94 136383 855 31560012
Eosinophilia 203.64 14.88 362 136115 22891 31537976
Drug level increased 202.78 14.88 334 136143 19852 31541015
Abnormal behaviour 201.07 14.88 365 136112 23463 31537404
Psychotic symptom 197.95 14.88 108 136369 1464 31559403
Drooling 195.63 14.88 137 136340 2958 31557909
Mean cell volume decreased 194.94 14.88 100 136377 1186 31559681
Pre-existing disease 194.48 14.88 51 136426 46 31560821
Mean cell haemoglobin decreased 193.08 14.88 104 136373 1372 31559495
Akathisia 191.67 14.88 194 136283 7059 31553808
Schizoaffective disorder 189.97 14.88 98 136379 1177 31559690
Plasma cell myeloma 189.62 14.88 14 136463 56517 31504350
Living in residential institution 188.97 14.88 66 136411 263 31560604
Imprisonment 187.40 14.88 73 136404 420 31560447
Joint swelling 185.79 14.88 11 136466 53420 31507447
Electrocardiogram QT prolonged 180.59 14.88 461 136016 37526 31523341
Drug hypersensitivity 178.70 14.88 46 136431 72553 31488314
Interstitial lung disease 178.29 14.88 26 136451 61377 31499490
Anosognosia 178.23 14.88 82 136395 751 31560116
Extrapyramidal disorder 173.13 14.88 233 136244 11545 31549322
Neoplasm malignant 171.30 14.88 299 136178 18632 31542235
Dyskinesia 169.73 14.88 315 136162 20595 31540272
Epistaxis 167.45 14.88 18 136459 53689 31507178
Obesity 163.79 14.88 220 136257 10880 31549987
Agitation 163.25 14.88 559 135918 53610 31507257
Muscle rigidity 162.89 14.88 207 136270 9690 31551177
Rheumatoid arthritis 159.88 14.88 12 136465 47797 31513070
Red blood cell count decreased 156.12 14.88 352 136125 26455 31534412
Muscle spasms 155.77 14.88 50 136427 68268 31492599
Stomatitis 150.91 14.88 4 136473 39434 31521433
General physical condition abnormal 147.82 14.88 121 136356 3325 31557542
Anaemia 147.24 14.88 452 136025 213070 31347797
Circulatory collapse 146.14 14.88 286 136191 19458 31541409
Tardive dyskinesia 145.63 14.88 148 136329 5411 31555456
Lymphocyte count decreased 144.29 14.88 292 136185 20357 31540510
Persecutory delusion 143.76 14.88 102 136375 2250 31558617
Hypoaesthesia 138.81 14.88 35 136442 55987 31504880
Pericarditis 138.00 14.88 185 136292 9131 31551736
Benign ethnic neutropenia 137.01 14.88 34 136443 18 31560849
International normalised ratio increased 136.38 14.88 17 136460 45206 31515661
Left ventricular dysfunction 135.84 14.88 184 136293 9173 31551694
Paraesthesia 135.18 14.88 37 136440 56034 31504833
Intestinal obstruction 132.93 14.88 282 136195 20328 31540539
Psoriasis 132.82 14.88 21 136456 46698 31514169
Body temperature increased 132.55 14.88 236 136241 14937 31545930
Neutrophil count abnormal 129.14 14.88 84 136393 1598 31559269
Choking 128.56 14.88 127 136350 4485 31556382
Enuresis 127.25 14.88 92 136385 2092 31558775
COVID-19 127.05 14.88 520 135957 54301 31506566
Delirium 127.01 14.88 430 136047 40991 31519876
Renal failure 126.58 14.88 210 136267 123120 31437747
Platelet count decreased 126.25 14.88 861 135616 109574 31451293
Dystonia 126.12 14.88 186 136291 10039 31550828
Intentional product use issue 125.84 14.88 29 136448 49318 31511549
Haematochezia 125.02 14.88 14 136463 40450 31520417
Injection site pain 123.92 14.88 6 136471 34628 31526239
Aspiration 123.32 14.88 189 136288 10557 31550310
Electrocardiogram abnormal 121.20 14.88 161 136316 7875 31552992
Cough 121.12 14.88 249 136228 134565 31426302
Myalgia 120.06 14.88 94 136383 77164 31483703
Troponin T increased 119.09 14.88 78 136399 1502 31559365
Ileus paralytic 118.62 14.88 131 136346 5277 31555590
Hypersensitivity 118.15 14.88 46 136431 55697 31505170
Hepatitis C 116.45 14.88 183 136294 10447 31550420
Blood prolactin abnormal 115.49 14.88 62 136415 812 31560055
Overdose 115.20 14.88 690 135787 83974 31476893
Cardiac failure congestive 113.09 14.88 105 136372 79282 31481585
Anaphylactic reaction 113.06 14.88 3 136474 29550 31531317
Left ventricular hypertrophy 112.29 14.88 148 136329 7184 31553683
Hypokalaemia 112.25 14.88 45 136432 53529 31507338
Orthostatic hypotension 111.79 14.88 290 136187 23829 31537038
Therapeutic product effect variable 111.47 14.88 81 136396 1857 31559010
Chills 110.51 14.88 94 136383 74056 31486811
Sinusitis 110.15 14.88 14 136463 36682 31524185
Pancytopenia 109.19 14.88 129 136348 87187 31473680
Mean cell volume increased 109.06 14.88 94 136383 2778 31558089
Thrombosis 106.59 14.88 31 136446 45120 31515747
Disinhibition 106.05 14.88 90 136387 2603 31558264
Therapy cessation 105.30 14.88 213 136264 14842 31546025
Dizziness 104.82 14.88 471 136006 198676 31362191
Haemoglobin increased 104.13 14.88 95 136382 3031 31557836
Suicide attempt 104.07 14.88 375 136102 36873 31523994
Refusal of examination 104.04 14.88 24 136453 3 31560864
Ascites 102.80 14.88 25 136452 40988 31519879
Bradycardia 101.96 14.88 89 136388 69238 31491629
Myoclonus 101.52 14.88 201 136276 13789 31547078
On and off phenomenon 100.97 14.88 79 136398 2031 31558836
Hypoglycaemia 100.06 14.88 47 136430 50899 31509968
Heart rate increased 99.25 14.88 395 136082 40715 31520152
Haematocrit decreased 99.22 14.88 320 136157 29741 31531126
Thinking abnormal 98.80 14.88 121 136356 5452 31555415
Megacolon 97.57 14.88 70 136407 1572 31559295
Seizure 95.69 14.88 746 135731 99022 31461845
Drug ineffective 95.67 14.88 1168 135309 394405 31166462
Hepatitis C virus test positive 95.32 14.88 39 136438 260 31560607
Mucosal inflammation 94.48 14.88 17 136460 34410 31526457
Lactic acidosis 93.90 14.88 13 136464 31924 31528943
Inappropriate schedule of product administration 93.65 14.88 51 136426 50772 31510095
Gastrointestinal haemorrhage 91.87 14.88 133 136344 82416 31478451
Somnolence 90.67 14.88 735 135742 98710 31462157
Psychiatric symptom 90.11 14.88 90 136387 3221 31557646
Mean cell haemoglobin concentration decreased 89.87 14.88 58 136419 1088 31559779
Parkinson's disease 88.38 14.88 64 136413 1459 31559408
Musculoskeletal pain 88.03 14.88 12 136465 29816 31531051
Echocardiogram abnormal 87.91 14.88 53 136424 877 31559990
Body mass index increased 87.79 14.88 54 136423 928 31559939
Freezing phenomenon 86.69 14.88 60 136417 1270 31559597
Disturbance in social behaviour 86.51 14.88 67 136410 1696 31559171
Swelling 85.73 14.88 27 136450 37331 31523536
Cardiac disorder 85.38 14.88 365 136112 38849 31522018
Muscular weakness 84.72 14.88 94 136383 65354 31495513
Haematuria 84.57 14.88 47 136430 46267 31514600
Apathy 84.43 14.88 121 136356 6361 31554506
Hallucination 82.51 14.88 407 136070 46003 31514864
Dyspnoea exertional 82.37 14.88 32 136445 38805 31522062
Coronavirus infection 80.40 14.88 89 136388 3594 31557273
Drug reaction with eosinophilia and systemic symptoms 79.87 14.88 16 136461 30002 31530865
Coma scale abnormal 79.61 14.88 89 136388 3634 31557233
Oedema 79.45 14.88 42 136435 42519 31518348
Renal impairment 78.75 14.88 158 136319 86191 31474676
Generalised tonic-clonic seizure 78.73 14.88 226 136251 19705 31541162
Weight decreased 78.40 14.88 388 136089 159564 31401303
Dysgeusia 78.13 14.88 6 136471 23460 31537407
Wheezing 77.40 14.88 29 136448 35957 31524910
Terminal state 76.68 14.88 87 136390 3611 31557256
Blood prolactin increased 75.97 14.88 60 136417 1564 31559303
Psychiatric evaluation 75.69 14.88 17 136460 0 31560867
Tobacco interaction 75.42 14.88 24 136453 66 31560801
Vision blurred 74.44 14.88 44 136433 41871 31518996
Pneumonitis 74.28 14.88 20 136457 30632 31530235
Stoma site discharge 73.98 14.88 48 136429 909 31559958
Abdominal pain upper 73.31 14.88 101 136376 63901 31496966
Troponin I increased 72.13 14.88 65 136412 2040 31558827
Arthritis 72.02 14.88 15 136462 27370 31533497
Social avoidant behaviour 71.35 14.88 76 136401 2937 31557930
Angioedema 70.80 14.88 28 136449 33590 31527277
Colitis ischaemic 70.22 14.88 107 136370 5945 31554922
Therapy interrupted 69.49 14.88 146 136331 10450 31550417
Haematoma 68.26 14.88 11 136466 24128 31536739
Cerebral haemorrhage 68.01 14.88 28 136449 32784 31528083
Rebound psychosis 67.86 14.88 26 136451 142 31560725
Prostate cancer 67.44 14.88 39 136438 37562 31523305
Dry skin 66.92 14.88 14 136463 25467 31535400
Herpes zoster 66.80 14.88 27 136450 31966 31528901
Delusional disorder, persecutory type 66.08 14.88 29 136448 235 31560632
Pneumocystis jirovecii pneumonia 65.81 14.88 3 136474 18248 31542619
Rash pruritic 65.29 14.88 12 136465 23926 31536941
Intentional self-injury 64.70 14.88 163 136314 13152 31547715
Haemorrhage 64.59 14.88 65 136412 47269 31513598
Oculogyric crisis 64.32 14.88 52 136425 1403 31559464
Melaena 64.30 14.88 30 136447 32624 31528243
Congestive cardiomyopathy 64.08 14.88 111 136366 6871 31553996
Sudden death 63.09 14.88 170 136307 14287 31546580
Dehydration 62.39 14.88 282 136195 118829 31442038
Multiple organ dysfunction syndrome 62.00 14.88 125 136352 68078 31492789
Acute myocardial infarction 61.48 14.88 77 136400 50746 31510121
Euphoric mood 61.39 14.88 90 136387 4830 31556037
Skin exfoliation 60.91 14.88 14 136463 23860 31537007
Fluid retention 60.45 14.88 16 136461 24786 31536081
Sexual dysfunction 60.25 14.88 99 136378 5869 31554998
Electrocardiogram T wave abnormal 60.19 14.88 50 136427 1403 31559464
Cerebral infarction 59.20 14.88 19 136458 25958 31534909
Rectal haemorrhage 59.16 14.88 42 136435 36262 31524605
Metabolic disorder 58.98 14.88 79 136398 3895 31556972
Intestinal pseudo-obstruction 58.47 14.88 51 136426 1532 31559335
Overweight 58.44 14.88 51 136426 1533 31559334
Hyponatraemia 58.32 14.88 146 136331 73653 31487214
Rash maculo-papular 58.28 14.88 19 136458 25700 31535167
Blood triglycerides increased 57.92 14.88 157 136320 13240 31547627
Influenza like illness 57.87 14.88 240 136237 25197 31535670
Bronchitis 57.76 14.88 49 136428 38668 31522199
Constipation 57.30 14.88 799 135678 123192 31437675
Skin lesion 57.28 14.88 8 136469 19519 31541348
Intestinal dilatation 57.27 14.88 43 136434 1038 31559829
Parkinsonism 56.96 14.88 111 136366 7525 31553342
Lung cancer metastatic 56.93 14.88 63 136414 2543 31558324
Insomnia 56.85 14.88 213 136264 94623 31466244
Blood urea decreased 56.57 14.88 41 136436 936 31559931
Ventricular tachycardia 56.43 14.88 16 136461 23685 31537182
Drug monitoring procedure incorrectly performed 56.19 14.88 25 136452 210 31560657
Impaired self-care 56.08 14.88 41 136436 949 31559918
Viral infection 56.05 14.88 171 136306 15422 31545445
Cholestasis 55.98 14.88 19 136458 25056 31535811
Hypocalcaemia 55.85 14.88 13 136464 21965 31538902
Osteoarthritis 55.49 14.88 8 136469 19059 31541808
Abdominal discomfort 55.48 14.88 85 136392 51482 31509385
Red blood cell count increased 55.22 14.88 48 136429 1435 31559432
Ejection fraction decreased 55.19 14.88 183 136294 17251 31543616
Stoma site erythema 55.05 14.88 35 136442 639 31560228
Suspiciousness 54.96 14.88 27 136450 290 31560577
Basal cell carcinoma 54.39 14.88 7 136470 18172 31542695
Nephrolithiasis 54.01 14.88 25 136452 27314 31533553
Pulmonary valve incompetence 53.83 14.88 37 136440 774 31560093
Drug dose titration not performed 53.27 14.88 26 136451 275 31560592
Type 2 diabetes mellitus 53.02 14.88 162 136315 14622 31546245
Rash erythematous 52.54 14.88 16 136461 22611 31538256
Bundle branch block right 52.27 14.88 102 136375 6922 31553945
Abdominal pain 51.62 14.88 392 136085 145560 31415307
Blood creatinine increased 51.50 14.88 203 136274 88875 31471992
Visual impairment 51.22 14.88 36 136441 31243 31529624
Gastrointestinal carcinoma 51.12 14.88 49 136428 1666 31559201
Refusal of treatment by patient 50.81 14.88 81 136396 4680 31556187
Arthropathy 50.69 14.88 20 136457 24031 31536836
Pericardial effusion 50.56 14.88 211 136266 22212 31538655
Full blood count decreased 50.39 14.88 6 136471 16534 31544333
Haemoptysis 50.18 14.88 39 136438 32150 31528717
Blister 50.09 14.88 14 136463 20922 31539945
Hyperbilirubinaemia 49.79 14.88 5 136472 15745 31545122
Heart rate decreased 49.72 14.88 30 136447 28236 31532631
Therapeutic product effect decreased 49.69 14.88 38 136439 31584 31529283
Myelodysplastic syndrome 49.69 14.88 11 136466 19240 31541627
Polydipsia psychogenic 49.55 14.88 19 136458 104 31560763
Hepatic function abnormal 49.28 14.88 63 136414 41159 31519708
Metabolic syndrome 49.15 14.88 46 136431 1517 31559350
Coagulopathy 48.98 14.88 10 136467 18505 31542362
Withdrawal catatonia 48.60 14.88 18 136459 88 31560779
Coronary artery disease 48.60 14.88 77 136400 46010 31514857
Pleurothotonus 48.50 14.88 39 136438 1044 31559823
Neck pain 48.37 14.88 19 136458 22891 31537976
Delusion of grandeur 48.28 14.88 33 136444 684 31560183
Increased appetite 48.27 14.88 93 136384 6251 31554616
Cataract 48.24 14.88 21 136456 23786 31537081
Hepatic failure 48.03 14.88 42 136435 32660 31528207
Neutrophil count 47.97 14.88 13 136464 15 31560852
Sedation complication 47.93 14.88 44 136433 1415 31559452
Gout 47.69 14.88 10 136467 18164 31542703
Basophil count increased 47.67 14.88 29 136448 488 31560379
Diverticulitis 47.43 14.88 11 136466 18634 31542233
Globulins decreased 47.24 14.88 21 136456 176 31560691
Condition aggravated 46.68 14.88 466 136011 163543 31397324
Obsessive thoughts 46.66 14.88 31 136446 612 31560255
Deep vein thrombosis 46.56 14.88 122 136355 60614 31500253
Nasopharyngitis 46.26 14.88 130 136347 63115 31497752
Bone pain 46.19 14.88 13 136464 19338 31541529
Weight increased 46.07 14.88 553 135924 82394 31478473
Visual acuity reduced 45.68 14.88 6 136471 15337 31545530
Contusion 45.46 14.88 45 136432 32983 31527884
Device related infection 44.82 14.88 8 136469 16291 31544576
Septic shock 44.78 14.88 141 136336 66017 31494850
Tinnitus 44.73 14.88 8 136469 16267 31544600
Haemorrhage intracranial 44.68 14.88 6 136471 15082 31545785
Candida infection 44.66 14.88 8 136469 16250 31544617
Mean cell haemoglobin concentration increased 44.66 14.88 24 136453 315 31560552
Neutrophil count normal 44.52 14.88 10 136467 0 31560867
Fibroma 44.24 14.88 22 136455 243 31560624
Drug intolerance 44.24 14.88 99 136378 51934 31508933
Acute psychosis 44.09 14.88 46 136431 1735 31559132
Drug eruption 43.81 14.88 12 136465 18175 31542692
Prostatic specific antigen increased 43.58 14.88 4 136473 13534 31547333
Diplopia 43.48 14.88 5 136472 14157 31546710
Foetal exposure during pregnancy 43.37 14.88 68 136409 40808 31520059
Staphylococcal infection 43.02 14.88 41 136436 30591 31530276
Lip swelling 42.72 14.88 4 136473 13319 31547548
Bradykinesia 42.37 14.88 64 136413 3528 31557339
Stoma site inflammation 42.36 14.88 26 136451 445 31560422
Disseminated intravascular coagulation 41.79 14.88 18 136459 20519 31540348
Red cell distribution width increased 41.76 14.88 80 136397 5354 31555513
Toxic epidermal necrolysis 41.54 14.88 16 136461 19508 31541359
Lymphoma 41.21 14.88 122 136355 10821 31550046
Alopecia 40.76 14.88 19 136458 20676 31540191
Dilatation ventricular 40.52 14.88 52 136425 2457 31558410
Burning sensation 40.44 14.88 11 136466 16736 31544131
Ankle fracture 40.34 14.88 63 136414 3576 31557291
Multiple sclerosis relapse 40.33 14.88 3 136474 12044 31548823
Dry mouth 40.24 14.88 28 136449 24430 31536437
Upper gastrointestinal haemorrhage 40.23 14.88 25 136452 23158 31537709
Angina pectoris 40.10 14.88 41 136436 29600 31531267
Gastrointestinal necrosis 40.08 14.88 58 136419 3076 31557791
Swelling face 40.07 14.88 21 136456 21369 31539498
Osteonecrosis 40.00 14.88 6 136471 13878 31546989
Hypotension 39.97 14.88 630 135847 203988 31356879
Stoma site reaction 39.94 14.88 19 136458 189 31560678
Hypoacusis 39.88 14.88 8 136469 14991 31545876
Suicidal ideation 39.83 14.88 281 136196 36125 31524742
Wrong technique in product usage process 39.81 14.88 51 136426 33292 31527575
Ventricular hypokinesia 39.73 14.88 73 136404 4733 31556134
Dysuria 39.72 14.88 28 136449 24266 31536601
Rhinorrhoea 39.68 14.88 25 136452 22987 31537880
Myelosuppression 39.59 14.88 8 136469 14912 31545955
Dysphemia 39.54 14.88 40 136437 1454 31559413
Drowning 39.29 14.88 24 136453 407 31560460
Flushing 39.27 14.88 43 136434 30085 31530782
Ventricular fibrillation 39.19 14.88 16 136461 18832 31542035
QRS axis abnormal 38.96 14.88 35 136442 1094 31559773
Hypervolaemia 38.76 14.88 15 136462 18236 31542631
Eye pain 38.65 14.88 4 136473 12300 31548567
Jaundice 38.63 14.88 44 136433 30243 31530624
Hepatotoxicity 38.54 14.88 17 136460 19109 31541758
Arteriosclerosis coronary artery 38.51 14.88 121 136356 11087 31549780
Respiratory failure 38.48 14.88 267 136210 101182 31459685
Faecal vomiting 38.34 14.88 23 136454 377 31560490
Red cell distribution width decreased 38.28 14.88 18 136459 174 31560693
Product quality issue 38.12 14.88 11 136466 16100 31544767
Colitis ulcerative 38.09 14.88 16 136461 18513 31542354
Hyperprolactinaemia 37.79 14.88 39 136438 1452 31559415
Urinary incontinence 37.51 14.88 161 136316 17159 31543708
Viral myocarditis 37.40 14.88 16 136461 121 31560746
Urinary tract infection 37.37 14.88 500 135977 76369 31484498
Rebound effect 37.36 14.88 50 136427 2463 31558404
Hypersplenism 37.24 14.88 22 136455 350 31560517
Waxy flexibility 37.04 14.88 15 136462 97 31560770
Acute respiratory distress syndrome 36.67 14.88 31 136446 24509 31536358
Bacteraemia 36.61 14.88 15 136462 17619 31543248
Inappropriate affect 36.54 14.88 26 136451 576 31560291
Chest discomfort 36.45 14.88 101 136376 49268 31511599
Volvulus 36.27 14.88 35 136442 1200 31559667
Fungal infection 36.20 14.88 9 136468 14542 31546325
Loss of libido 36.14 14.88 48 136429 2347 31558520
Drug-induced liver injury 36.13 14.88 31 136446 24332 31536535
Dysphonia 36.01 14.88 22 136455 20569 31540298
Eosinophilic colitis 35.95 14.88 18 136459 202 31560665
Ischaemic stroke 35.95 14.88 14 136463 16957 31543910
Left atrial dilatation 35.90 14.88 41 136436 1714 31559153
Diabetes mellitus 35.77 14.88 309 136168 42247 31518620
Product prescribing error 35.75 14.88 20 136457 19622 31541245
Waist circumference increased 35.57 14.88 29 136448 792 31560075
Drug level changed 35.56 14.88 21 136456 334 31560533
Dementia with Lewy bodies 35.35 14.88 27 136450 669 31560198
Nasal congestion 35.33 14.88 22 136455 20359 31540508
Electroencephalogram abnormal 35.23 14.88 47 136430 2308 31558559
Neoplasm progression 34.98 14.88 22 136455 20250 31540617
Premature baby 34.95 14.88 17 136460 18049 31542818
Pleural effusion 34.79 14.88 185 136292 74735 31486132
Neuralgia 34.48 14.88 5 136472 11861 31549006
Clostridium difficile colitis 34.38 14.88 9 136468 14047 31546820
Treatment failure 34.36 14.88 78 136399 40714 31520153
Cardiac failure 34.20 14.88 223 136254 85730 31475137
Feeling abnormal 34.16 14.88 128 136349 56874 31503993
Chronic kidney disease 34.15 14.88 70 136407 37905 31522962
Monocyte count decreased 34.07 14.88 33 136444 1137 31559730
Total cholesterol/HDL ratio increased 34.00 14.88 16 136461 155 31560712
Monocytosis 33.93 14.88 22 136455 416 31560451
Lymphocyte percentage increased 33.78 14.88 17 136460 193 31560674
Oxygen saturation decreased 33.71 14.88 104 136373 49011 31511856
Flatulence 33.48 14.88 20 136457 18928 31541939
Dementia 33.28 14.88 123 136354 12237 31548630
Leukaemia 33.10 14.88 61 136416 3964 31556903
Spleen congestion 32.85 14.88 19 136458 290 31560577
Toxic skin eruption 32.79 14.88 3 136474 10177 31550690
Shock haemorrhagic 32.78 14.88 3 136474 10174 31550693
Dysarthria 32.64 14.88 243 136234 31774 31529093
Lymphocytosis 32.63 14.88 43 136434 2086 31558781
Acute myeloid leukaemia 32.58 14.88 20 136457 18652 31542215
Presyncope 32.48 14.88 17 136460 17311 31543556
Mania 32.38 14.88 100 136377 9077 31551790
Clostridium difficile infection 32.31 14.88 17 136460 17262 31543605
Bone marrow failure 32.25 14.88 44 136433 27964 31532903
Discomfort 32.24 14.88 15 136462 16341 31544526
Eczema 32.20 14.88 13 136464 15404 31545463
Electrocardiogram T wave inversion 32.19 14.88 42 136435 2018 31558849
Blood pressure decreased 32.18 14.88 103 136374 47988 31512879
Posture abnormal 32.12 14.88 42 136435 2022 31558845
Depression 32.03 14.88 244 136233 90571 31470296
Loss of personal independence in daily activities 32.01 14.88 45 136432 28243 31532624
Product use in unapproved indication 31.97 14.88 273 136204 98898 31461969
Angina unstable 31.88 14.88 5 136472 11190 31549677
Encephalopathy 31.70 14.88 57 136420 32417 31528450
Chromaturia 31.61 14.88 9 136468 13289 31547578
Malignant catatonia 31.38 14.88 17 136460 227 31560640
SARS-CoV-2 test positive 31.25 14.88 63 136414 4378 31556489
Brain injury 30.95 14.88 74 136403 5776 31555091
Polydipsia 30.83 14.88 55 136422 3485 31557382
Hypoxia 30.78 14.88 112 136365 50201 31510666
Blood test abnormal 30.69 14.88 76 136401 6065 31554802
Hypercalcaemia 30.58 14.88 11 136466 13989 31546878
Obsessive-compulsive symptom 30.54 14.88 14 136463 127 31560740
Electrocardiogram change 30.51 14.88 24 136453 622 31560245
Blood lactate dehydrogenase decreased 30.30 14.88 15 136462 164 31560703
Neurotoxicity 30.29 14.88 16 136461 16210 31544657
Bipolar disorder 30.08 14.88 56 136421 3668 31557199
Productive cough 30.01 14.88 62 136415 33478 31527389
Blood cholesterol increased 29.89 14.88 148 136329 16745 31544122
Water intoxication 29.83 14.88 20 136457 401 31560466
Joint stiffness 29.64 14.88 4 136473 10017 31550850
Ocular hyperaemia 29.59 14.88 4 136473 10005 31550862
Gastric ulcer 29.50 14.88 13 136464 14621 31546246
Incontinence 29.43 14.88 69 136408 5317 31555550
Hypertension 29.34 14.88 382 136095 127718 31433149
Wrong patient received product 29.34 14.88 45 136432 2514 31558353
Dyspepsia 29.28 14.88 60 136417 32493 31528374
Proteinuria 29.19 14.88 18 136459 16745 31544122
Tricuspid valve incompetence 29.13 14.88 94 136383 8735 31552132
Pulmonary hypertension 29.11 14.88 26 136451 20015 31540852
Skin discolouration 29.11 14.88 17 136460 16290 31544577
Skin ulcer 28.94 14.88 26 136451 19959 31540908
Delusional disorder, unspecified type 28.93 14.88 24 136453 672 31560195
Hyperglycaemia 28.93 14.88 72 136405 36404 31524463
Lower limb fracture 28.91 14.88 56 136421 3779 31557088
Sopor 28.67 14.88 112 136365 11440 31549427
Medication error 28.65 14.88 182 136295 22590 31538277
Suicidal behaviour 28.53 14.88 33 136444 1399 31559468
Granulocytosis 28.50 14.88 16 136461 230 31560637
Blood bilirubin increased 28.14 14.88 69 136408 35067 31525800
Migraine 27.95 14.88 13 136464 14167 31546700
Infection 27.60 14.88 501 135976 81430 31479437
Feeling hot 27.48 14.88 18 136459 16215 31544652
Haemodialysis 27.47 14.88 5 136472 10040 31550827
Hypothermia 27.42 14.88 97 136380 9447 31551420
Blood disorder 27.40 14.88 48 136429 2998 31557869
Hot flush 27.37 14.88 18 136459 16178 31544689
Appendicitis perforated 27.25 14.88 36 136441 1751 31559116
Anion gap increased 27.14 14.88 35 136442 1662 31559205
Blood pressure increased 27.12 14.88 216 136261 79417 31481450
Hypoalbuminaemia 27.09 14.88 7 136470 11021 31549846
Enterococcal infection 27.01 14.88 3 136474 8728 31552139
Epilepsy 26.99 14.88 169 136308 20872 31539995
Photosensitivity reaction 26.93 14.88 5 136472 9899 31550968
Throat irritation 26.89 14.88 4 136473 9310 31551557
Investigation noncompliance 26.71 14.88 6 136471 0 31560867
Pseudomonas infection 26.58 14.88 8 136469 11393 31549474
Restlessness 26.54 14.88 182 136295 23179 31537688
Haemolytic anaemia 26.52 14.88 5 136472 9791 31551076
Oral pain 26.40 14.88 5 136472 9760 31551107
Appendicectomy 26.40 14.88 25 136452 837 31560030
Lymphadenopathy 26.26 14.88 45 136432 26076 31534791
Pulmonary fibrosis 26.20 14.88 20 136457 16640 31544227
Gamma-glutamyltransferase increased 26.03 14.88 207 136270 27618 31533249
Confusional state 26.03 14.88 755 135722 132579 31428288
Hyperkinesia 25.97 14.88 34 136443 1639 31559228
Frequent bowel movements 25.83 14.88 6 136471 10153 31550714
Purpura 25.82 14.88 5 136472 9605 31551262
Rash papular 25.67 14.88 3 136474 8389 31552478
Learning disability 25.66 14.88 17 136460 334 31560533
Patient restraint 25.62 14.88 11 136466 84 31560783
Blindness 25.54 14.88 11 136466 12540 31548327
Pseudophaeochromocytoma 25.42 14.88 7 136470 9 31560858
Blood creatinine decreased 25.27 14.88 44 136433 2735 31558132
Affective disorder 25.10 14.88 52 136425 3684 31557183
Delusional perception 25.06 14.88 13 136464 158 31560709
Suspected COVID-19 25.00 14.88 25 136452 896 31559971
Subacute endocarditis 24.99 14.88 9 136468 40 31560827
Reduced facial expression 24.94 14.88 24 136453 820 31560047
Electrocardiogram QT interval abnormal 24.87 14.88 11 136466 91 31560776
Contraindicated product administered 24.86 14.88 158 136319 19614 31541253
Mutism 24.76 14.88 23 136454 751 31560116
Mean cell haemoglobin increased 24.70 14.88 30 136447 1340 31559527
Asthma 24.67 14.88 97 136380 42514 31518353
Dyslipidaemia 24.67 14.88 72 136405 6334 31554533
Personality change 24.66 14.88 60 136417 4735 31556132
Nephropathy toxic 24.66 14.88 9 136468 11344 31549523
Skin disorder 24.61 14.88 11 136466 12270 31548597
Gastric haemorrhage 24.52 14.88 6 136471 9799 31551068
Drug dependence 24.49 14.88 37 136440 22542 31538325
Transaminases increased 24.41 14.88 42 136435 24299 31536568
Erythema multiforme 24.41 14.88 3 136474 8068 31552799
Obstructive airways disorder 24.37 14.88 12 136465 12652 31548215
Testicular germ cell cancer metastatic 24.27 14.88 10 136467 68 31560799
Bundle branch block left 24.18 14.88 65 136412 5453 31555414
Renal tubular necrosis 24.14 14.88 17 136460 14742 31546125
Polyneuropathy 24.07 14.88 13 136464 13009 31547858
Staphylococcal sepsis 24.03 14.88 5 136472 9132 31551735
Akinesia 24.00 14.88 36 136441 1972 31558895
Acne 23.92 14.88 7 136470 10153 31550714
Intervertebral disc protrusion 23.89 14.88 5 136472 9095 31551772
Conduction disorder 23.86 14.88 35 136442 1879 31558988
Amnesia 23.82 14.88 40 136437 23362 31537505
Chronic hepatitis C 23.80 14.88 17 136460 379 31560488
Electrocardiogram ST segment elevation 23.71 14.88 58 136419 4593 31556274
Encephalitis toxic 23.64 14.88 15 136462 273 31560594
Therapy non-responder 23.62 14.88 71 136406 33740 31527127
Swollen tongue 23.55 14.88 13 136464 12849 31548018
Anisocytosis 23.46 14.88 17 136460 388 31560479
Haemorrhoids 23.42 14.88 12 136465 12370 31548497
Empyema 23.26 14.88 44 136433 2917 31557950
Intestinal ischaemia 23.23 14.88 75 136402 6970 31553897
Seminoma 23.20 14.88 14 136463 232 31560635
Amylase decreased 23.08 14.88 8 136469 31 31560836
Tangentiality 23.07 14.88 11 136466 110 31560757
Gastrooesophageal reflux disease 23.04 14.88 72 136405 33799 31527068
Blood pressure systolic increased 23.01 14.88 30 136447 19440 31541427
Skin cancer 22.97 14.88 6 136471 9379 31551488
Autism spectrum disorder 22.95 14.88 37 136440 2158 31558709
Blood osmolarity decreased 22.87 14.88 19 136458 533 31560334
Bladder cancer 22.74 14.88 18 136459 14707 31546160
Tension 22.68 14.88 35 136442 1966 31558901
Anuria 22.68 14.88 7 136470 9807 31551060
Nightmare 22.61 14.88 12 136465 12125 31548742
Excessive masturbation 22.58 14.88 10 136467 83 31560784
Substance use 22.52 14.88 19 136458 545 31560322
Testis cancer 22.42 14.88 28 136449 1287 31559580
Alcohol abuse 22.30 14.88 56 136421 4508 31556359
Stoma site extravasation 22.27 14.88 10 136467 86 31560781
Thalassaemia 22.26 14.88 5 136472 0 31560867
Foreign body ingestion 22.26 14.88 5 136472 0 31560867
End stage renal disease 22.25 14.88 4 136473 8105 31552762
Hypersensitivity myocarditis 22.13 14.88 8 136469 36 31560831
Pickwickian syndrome 22.12 14.88 9 136468 59 31560808
Fall 22.10 14.88 996 135481 185093 31375774
Lacrimation increased 22.10 14.88 3 136474 7479 31553388
Testicular cancer metastatic 22.00 14.88 9 136468 60 31560807
Psychotic behaviour 21.82 14.88 20 136457 642 31560225
Deafness 21.57 14.88 9 136468 10456 31550411
Blunted affect 21.53 14.88 15 136462 321 31560546
Musculoskeletal stiffness 21.50 14.88 98 136379 41227 31519640
Urine output decreased 21.50 14.88 7 136470 9479 31551388
Nervousness 21.50 14.88 12 136465 11788 31549079
Illusion 21.27 14.88 21 136456 741 31560126
Drug abuse 21.09 14.88 259 136218 87499 31473368
Blood sodium increased 21.07 14.88 40 136437 2659 31558208
Withdrawal syndrome 20.98 14.88 103 136374 11614 31549253
Quarantine 20.85 14.88 7 136470 24 31560843
Osteoporosis 20.78 14.88 12 136465 11571 31549296
Oliguria 20.76 14.88 4 136473 7713 31553154
Haematotoxicity 20.75 14.88 3 136474 7134 31553733
Myocardial fibrosis 20.68 14.88 25 136452 1111 31559756
Cardio-respiratory arrest 20.66 14.88 134 136343 51592 31509275
Subdural haematoma 20.66 14.88 31 136446 18940 31541927
Hepatic enzyme increased 20.62 14.88 82 136395 35826 31525041
Ideas of reference 20.54 14.88 8 136469 46 31560821
Crush syndrome 20.54 14.88 8 136469 46 31560821
Face oedema 20.52 14.88 10 136467 10606 31550261
Aplastic anaemia 20.49 14.88 7 136470 9196 31551671
Blood osmolarity increased 20.45 14.88 15 136462 349 31560518
Aortic dilatation 20.42 14.88 26 136451 1219 31559648
Radiation inflammation 20.38 14.88 18 136459 550 31560317
Liver function test increased 20.33 14.88 15 136462 12699 31548168
Pulmonary haemorrhage 20.25 14.88 8 136469 9607 31551260
Large intestine polyp 20.19 14.88 3 136474 6989 31553878
Rash macular 20.17 14.88 12 136465 11383 31549484
Atrial flutter 20.13 14.88 20 136457 14635 31546232
Osteomyelitis 20.09 14.88 20 136457 14623 31546244
Spinal osteoarthritis 19.97 14.88 3 136474 6932 31553935
Hepatic cytolysis 19.72 14.88 11 136466 10812 31550055
Judgement impaired 19.71 14.88 18 136459 575 31560292
Heat stroke 19.70 14.88 22 136455 897 31559970
Hepatic encephalopathy 19.54 14.88 18 136459 13653 31547214
Hyperosmolar state 19.53 14.88 15 136462 375 31560492
Unresponsive to stimuli 19.46 14.88 183 136294 25617 31535250
Thought blocking 19.32 14.88 10 136467 121 31560746
Disorientation 19.31 14.88 210 136267 30534 31530333
Cardiomegaly 19.21 14.88 117 136360 14308 31546559
Cardiac failure chronic 19.20 14.88 4 136473 7299 31553568
Alcohol problem 19.14 14.88 9 136468 87 31560780
Hiccups 19.12 14.88 8 136469 9279 31551588
Benign prostatic hyperplasia 19.10 14.88 17 136460 13108 31547759
C-reactive protein abnormal 18.95 14.88 5 136472 7764 31553103
Joint range of motion decreased 18.91 14.88 3 136474 6658 31554209
COVID-19 pneumonia 18.89 14.88 16 136461 12639 31548228
Lymphocyte morphology abnormal 18.79 14.88 16 136461 465 31560402
Vertigo 18.75 14.88 45 136432 23040 31537827
Electrocardiogram T wave amplitude decreased 18.69 14.88 12 136465 223 31560644
Throat tightness 18.58 14.88 5 136472 7664 31553203
Blood creatine phosphokinase decreased 18.50 14.88 16 136461 475 31560392
Rib fracture 18.49 14.88 18 136459 13298 31547569
Somnolence neonatal 18.47 14.88 6 136471 18 31560849
Status epilepticus 18.45 14.88 15 136462 12091 31548776
Pancreatitis acute 18.43 14.88 53 136424 25547 31535320
Myopathy 18.42 14.88 12 136465 10840 31550027
Exposure during pregnancy 18.36 14.88 7 136470 8591 31552276
Schizoaffective disorder bipolar type 18.32 14.88 8 136469 64 31560803
Drop attacks 18.31 14.88 17 136460 555 31560312
Anticholinergic syndrome 18.28 14.88 23 136454 1065 31559802
Liver disorder 18.25 14.88 66 136411 29641 31531226
Brain neoplasm 18.13 14.88 40 136437 2960 31557907
Compulsions 17.99 14.88 11 136466 187 31560680
Cholangitis 17.91 14.88 6 136471 7980 31552887
Mean platelet volume increased 17.89 14.88 16 136461 497 31560370
Blood cannabinoids 17.81 14.88 4 136473 0 31560867
Cholinergic rebound syndrome 17.81 14.88 4 136473 0 31560867
Eosinopenia 17.81 14.88 4 136473 0 31560867
Oral candidiasis 17.80 14.88 13 136464 11064 31549803
Duodenal ulcer 17.68 14.88 10 136467 9754 31551113
Incoherent 17.61 14.88 49 136428 4195 31556672
Peripheral sensory neuropathy 17.58 14.88 3 136474 6312 31554555
Device malfunction 17.50 14.88 9 136468 9257 31551610
Hepatocellular injury 17.49 14.88 42 136435 21502 31539365
Embedded device 17.46 14.88 12 136465 251 31560616
Gender dysphoria 17.45 14.88 7 136470 44 31560823
Throat cancer 17.38 14.88 22 136455 1025 31559842
Stoma site odour 17.36 14.88 6 136471 23 31560844
Stoma site irritation 17.33 14.88 10 136467 152 31560715
Alcohol detoxification 17.32 14.88 7 136470 45 31560822
Dermatitis bullous 17.31 14.88 3 136474 6242 31554625
Haematology test abnormal 17.19 14.88 7 136470 46 31560821
Coprolalia 17.16 14.88 6 136471 24 31560843
Compensatory sweating 17.16 14.88 6 136471 24 31560843
Enterocolitis 17.15 14.88 5 136472 7269 31553598
Blood folate decreased 17.06 14.88 18 136459 688 31560179
Haemolysis 16.94 14.88 5 136472 7211 31553656
Drug titration error 16.93 14.88 15 136462 460 31560407
Musculoskeletal chest pain 16.90 14.88 9 136468 9076 31551791
Acidosis 16.88 14.88 11 136466 9935 31550932
Flat affect 16.83 14.88 19 136458 784 31560083
Basilar migraine 16.81 14.88 5 136472 10 31560857
Catecholamines urine increased 16.81 14.88 5 136472 10 31560857
Flank pain 16.79 14.88 3 136474 6106 31554761
Intentional medical device removal by patient 16.78 14.88 12 136465 268 31560599
Electroconvulsive therapy 16.78 14.88 6 136471 26 31560841
Sinus rhythm 16.72 14.88 13 136464 331 31560536
Stupor 16.69 14.88 37 136440 2747 31558120
Localised infection 16.57 14.88 25 136452 15240 31545627
Limb discomfort 16.51 14.88 12 136465 10237 31550630
Norepinephrine increased 16.49 14.88 5 136472 11 31560856
Eye disorder 16.44 14.88 8 136469 8494 31552373
Cardiac septal hypertrophy 16.40 14.88 12 136465 278 31560589
Drug level fluctuating 16.35 14.88 15 136462 482 31560385
High-grade B-cell lymphoma 16.30 14.88 10 136467 171 31560696
Cholinergic syndrome 16.27 14.88 15 136462 485 31560382
Stab wound 16.26 14.88 11 136466 224 31560643
Laparotomy 16.26 14.88 12 136465 282 31560585
Musculoskeletal discomfort 16.24 14.88 5 136472 7018 31553849
Retrograde ejaculation 16.23 14.88 13 136464 346 31560521
Cardiac dysfunction 16.20 14.88 30 136447 1957 31558910
Myelocyte count increased 16.10 14.88 13 136464 350 31560517
Colitis 16.10 14.88 83 136394 33804 31527063
Full blood count abnormal 16.06 14.88 123 136354 16224 31544643
Viral pericarditis 15.93 14.88 6 136471 31 31560836
Eosinophilic pleural effusion 15.89 14.88 11 136466 233 31560634
Postmortem blood drug level increased 15.89 14.88 11 136466 233 31560634
Limb injury 15.86 14.88 12 136465 10029 31550838
Substance abuse 15.85 14.88 67 136410 7091 31553776
Tooth disorder 15.82 14.88 12 136465 10017 31550850
Peritonitis bacterial 15.81 14.88 3 136474 5849 31555018
Systolic dysfunction 15.79 14.88 33 136444 2353 31558514
Self-induced vomiting 15.58 14.88 4 136473 3 31560864
Sepsis 15.57 14.88 517 135960 151412 31409455
ECG signs of myocardial ischaemia 15.57 14.88 10 136467 186 31560681
Generalised oedema 15.45 14.88 16 136461 11485 31549382
Somatic delusion 15.44 14.88 8 136469 97 31560770
Squamous cell carcinoma 15.43 14.88 14 136463 10697 31550170
Myositis 15.40 14.88 15 136462 11079 31549788
Eating disorder 15.35 14.88 69 136408 7500 31553367
Fistula 15.32 14.88 3 136474 5718 31555149
Subarachnoid haemorrhage 15.31 14.88 13 136464 10258 31550609
White blood cell disorder 15.29 14.88 25 136452 1476 31559391
Blood urea nitrogen/creatinine ratio decreased 15.19 14.88 6 136471 36 31560831
Electrocardiogram QT shortened 15.19 14.88 9 136468 144 31560723
Hemiplegia 15.17 14.88 5 136472 6717 31554150
Somatic dysfunction 15.15 14.88 5 136472 16 31560851
Mean cell volume abnormal 15.14 14.88 13 136464 382 31560485
Dialysis 15.11 14.88 14 136463 10589 31550278
Electrolyte imbalance 15.11 14.88 18 136459 12130 31548737
Cogwheel rigidity 15.10 14.88 23 136454 1277 31559590
Brugada syndrome 15.07 14.88 17 136460 701 31560166
Infantile back arching 15.05 14.88 4 136473 4 31560863
Behaviour disorder 14.99 14.88 47 136430 4300 31556567
Subileus 14.94 14.88 37 136440 2953 31557914

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 19428.50 15.72 10023 149552 247133 70521736
Neutrophil count increased 6512.13 15.72 2398 157177 24397 70744472
Neutrophilia 5758.81 15.72 1598 157977 5623 70763246
White blood cell count increased 5416.52 15.72 2787 156788 66786 70702083
Granulocytopenia 5386.97 15.72 1655 157920 8992 70759877
Schizophrenia 3512.07 15.72 1347 158228 15421 70753448
Differential white blood cell count abnormal 3454.59 15.72 811 158764 1077 70767792
Antipsychotic drug level increased 2458.11 15.72 776 158799 4664 70764205
Death 2323.23 15.72 4121 155454 505940 70262929
White blood cell count decreased 2213.31 15.72 2297 157278 167844 70601025
Salivary hypersecretion 2141.84 15.72 877 158698 12048 70756821
Myocarditis 2132.82 15.72 976 158599 17817 70751052
Hospitalisation 2037.33 15.72 1600 157975 80968 70687901
Neutrophil count decreased 1977.62 15.72 1580 157995 81976 70686893
Psychotic disorder 1684.61 15.72 1052 158523 36649 70732220
Agranulocytosis 1622.80 15.72 1053 158522 39245 70729624
Leukopenia 1535.92 15.72 1522 158053 105038 70663831
Sedation 1297.33 15.72 972 158603 45759 70723110
Neuroleptic malignant syndrome 1274.53 15.72 770 158805 25237 70743632
Mental impairment 1148.87 15.72 624 158951 16631 70752238
Platelet count increased 995.23 15.72 601 158974 19672 70749197
Leukocytosis 832.20 15.72 700 158875 38968 70729901
Pain 832.03 15.72 198 159377 628618 70140251
Tachycardia 828.11 15.72 1366 158209 157180 70611689
Arthralgia 820.58 15.72 89 159486 503301 70265568
Hallucination, auditory 717.98 15.72 471 159104 17857 70751012
Rash 702.60 15.72 147 159428 510415 70258454
Nausea 701.42 15.72 538 159037 851550 69917319
Treatment noncompliance 684.48 15.72 673 158902 45901 70722968
Antipsychotic drug level decreased 670.36 15.72 197 159378 889 70767980
Headache 657.75 15.72 243 159332 580162 70188707
Anosognosia 651.24 15.72 245 159330 2640 70766229
Rheumatoid arthritis 623.66 15.72 6 159569 291799 70477070
Antipsychotic drug level above therapeutic 623.19 15.72 215 159360 1764 70767105
Pruritus 603.07 15.72 46 159529 345514 70423355
Delusion 600.22 15.72 429 159146 18736 70750133
Haemoglobin decreased 595.61 15.72 1380 158195 203779 70565090
Catatonia 580.15 15.72 308 159267 7825 70761044
Fatigue 567.82 15.72 613 158962 823706 69945163
Blood prolactin abnormal 564.89 15.72 219 159356 2577 70766292
Troponin increased 560.00 15.72 389 159186 16225 70752644
Eosinophil count decreased 556.11 15.72 218 159357 2648 70766221
Eosinophil count increased 554.72 15.72 374 159201 14848 70754021
Dystonia 544.53 15.72 409 159166 19297 70749572
Dyskinesia 525.89 15.72 551 159024 40523 70728346
C-reactive protein increased 523.29 15.72 912 158663 109605 70659264
Diarrhoea 519.06 15.72 601 158974 782740 69986129
Disturbance in social behaviour 508.03 15.72 226 159349 3841 70765028
Joint swelling 473.79 15.72 23 159552 253188 70515681
Sexual dysfunction 454.03 15.72 245 159330 6436 70762433
Antipsychotic drug level below therapeutic 451.01 15.72 142 159433 843 70768026
Sinus tachycardia 450.40 15.72 464 159111 33449 70735420
Dyspnoea 431.45 15.72 668 158907 769392 69999477
Pain in extremity 425.73 15.72 107 159468 327975 70440894
Monocyte count increased 421.14 15.72 261 159314 8948 70759921
Blood creatine phosphokinase increased 421.05 15.72 600 158975 60663 70708206
Pre-existing disease 420.44 15.72 97 159478 112 70768757
Metabolic disorder 414.33 15.72 246 159329 7794 70761075
Drug level increased 408.61 15.72 456 159119 36013 70732856
Peripheral swelling 394.69 15.72 38 159537 236525 70532344
Drug hypersensitivity 391.89 15.72 61 159514 262398 70506471
Faecaloma 369.39 15.72 252 159323 10199 70758670
Eosinophilia 365.04 15.72 452 159123 39867 70729002
Extrapyramidal disorder 348.69 15.72 323 159252 20427 70748442
Swelling 337.58 15.72 22 159553 188517 70580352
Back pain 328.21 15.72 101 159474 271051 70497818
Personality change 328.11 15.72 220 159355 8650 70760219
Alopecia 325.54 15.72 34 159541 198456 70570413
Lymphocyte count increased 323.45 15.72 181 159394 5115 70763754
Hypersensitivity 319.97 15.72 64 159511 229748 70539121
Erythema 307.99 15.72 42 159533 199521 70569348
Urticaria 307.50 15.72 14 159561 163035 70605834
Sinusitis 305.11 15.72 19 159556 169176 70599693
Pneumonia aspiration 305.05 15.72 522 159053 61767 70707102
Aggression 304.57 15.72 455 159120 47991 70720878
Mean cell haemoglobin decreased 302.71 15.72 173 159402 5095 70763774
Mental disorder 300.82 15.72 344 159231 27896 70740973
Platelet count decreased 298.72 15.72 981 158594 177241 70591628
Suicide attempt 295.91 15.72 592 158983 78918 70689951
Asthenia 290.65 15.72 362 159213 457304 70311565
Lymphocyte count decreased 280.99 15.72 414 159161 43125 70725744
Psychiatric decompensation 279.80 15.72 136 159439 2851 70766018
Paranoia 278.72 15.72 263 159312 17025 70751844
Agitation 275.84 15.72 633 158942 92742 70676127
Electrocardiogram QT prolonged 274.65 15.72 591 158984 82926 70685943
Acute kidney injury 269.61 15.72 407 159168 474217 70294652
Obsessive-compulsive disorder 265.51 15.72 160 159415 5210 70763659
Gastrointestinal hypomotility 263.73 15.72 112 159463 1691 70767178
Drooling 258.57 15.72 158 159417 5278 70763591
Red blood cell count decreased 256.54 15.72 438 159137 51723 70717146
Stomatitis 256.33 15.72 7 159568 128504 70640365
Abdominal discomfort 256.04 15.72 82 159493 214576 70554293
Arthropathy 255.83 15.72 22 159553 150035 70618834
Drug intolerance 254.06 15.72 95 159480 225592 70543277
Mean cell volume decreased 251.80 15.72 144 159431 4246 70764623
Muscle rigidity 243.66 15.72 253 159322 18397 70750472
Akathisia 241.45 15.72 209 159366 12084 70756785
Malignant neoplasm progression 237.84 15.72 8 159567 121731 70647138
Psychotic symptom 237.42 15.72 114 159461 2324 70766545
Drug interaction 233.85 15.72 1563 158012 379878 70388991
Injection site pain 232.40 15.72 7 159568 117612 70651257
Abnormal behaviour 229.70 15.72 334 159241 34375 70734494
Somnolence 229.35 15.72 1027 158548 214579 70554290
Febrile neutropenia 228.29 15.72 87 159488 204231 70564638
Overdose 221.57 15.72 861 158714 168884 70599985
Haematocrit decreased 219.83 15.72 432 159143 56826 70712043
Decreased appetite 218.57 15.72 218 159357 304562 70464307
Oedema peripheral 214.94 15.72 123 159452 227968 70540901
Nasopharyngitis 213.46 15.72 117 159458 222089 70546780
Mean cell haemoglobin concentration decreased 209.99 15.72 125 159450 3978 70764891
Hypoaesthesia 203.37 15.72 48 159527 153691 70615178
Disease progression 199.34 15.72 53 159522 156619 70612250
Enuresis 198.28 15.72 107 159468 2810 70766059
Abdominal pain upper 197.80 15.72 94 159481 193508 70575361
Cough 195.41 15.72 268 159307 325109 70443760
Living in residential institution 195.18 15.72 68 159507 576 70768293
Systemic lupus erythematosus 194.57 15.72 8 159567 101894 70666975
Aspiration 194.50 15.72 219 159356 17456 70751413
Therapeutic product effect decreased 194.49 15.72 42 159533 142976 70625893
Neuropathy peripheral 188.11 15.72 30 159545 126866 70642003
Intestinal obstruction 186.93 15.72 323 159252 38502 70730367
Tardive dyskinesia 183.35 15.72 163 159412 9766 70759103
Off label use 181.96 15.72 958 158617 742102 70026767
Discomfort 180.95 15.72 15 159560 105421 70663448
On and off phenomenon 180.50 15.72 99 159476 2687 70766182
Glossodynia 179.18 15.72 3 159572 86484 70682385
Mean cell volume increased 178.19 15.72 127 159448 5517 70763352
Paraesthesia 178.15 15.72 53 159522 145484 70623385
Schizoaffective disorder 177.22 15.72 88 159487 1935 70766934
Cardiomyopathy 174.81 15.72 254 159321 26119 70742750
Psoriasis 174.61 15.72 12 159563 98421 70670448
Generalised tonic-clonic seizure 174.25 15.72 326 159249 41335 70727534
Troponin T increased 173.93 15.72 94 159481 2476 70766393
Blister 173.35 15.72 14 159561 100512 70668357
Lung neoplasm malignant 172.37 15.72 244 159331 24498 70744371
Intentional product use issue 172.34 15.72 31 159544 120111 70648758
Delirium 168.82 15.72 457 159118 74157 70694712
Arthritis 167.98 15.72 14 159561 97966 70670903
Myoclonus 164.85 15.72 247 159328 26108 70742761
Muscle spasms 164.84 15.72 70 159505 153976 70614893
Epistaxis 164.58 15.72 19 159556 102608 70666261
Pleurothotonus 161.41 15.72 87 159488 2279 70766590
Hyperkalaemia 160.71 15.72 24 159551 106567 70662302
Hallucination 160.59 15.72 455 159120 75805 70693064
Benign ethnic neutropenia 160.25 15.72 35 159540 24 70768845
Ileus paralytic 160.14 15.72 143 159432 8618 70760251
Wound 159.03 15.72 18 159557 98714 70670155
Choking 157.14 15.72 157 159418 10903 70757966
Contusion 156.03 15.72 47 159528 127989 70640880
Musculoskeletal pain 154.59 15.72 13 159562 90314 70678555
Refusal of examination 153.13 15.72 42 159533 139 70768730
Orthostatic hypotension 151.86 15.72 350 159225 51393 70717476
Impaired healing 148.48 15.72 4 159571 74370 70694499
Haemoglobin increased 145.07 15.72 112 159463 5503 70763366
Interstitial lung disease 141.79 15.72 31 159544 104654 70664215
Psychiatric symptom 140.78 15.72 118 159457 6526 70762343
Atrial fibrillation 137.71 15.72 127 159448 184221 70584648
Myalgia 137.26 15.72 106 159469 167786 70601083
Sudden death 136.89 15.72 201 159374 20863 70748006
Anaphylactic reaction 133.38 15.72 9 159566 74965 70693904
Pericardial effusion 131.99 15.72 291 159284 41485 70727384
Blood glucose increased 129.91 15.72 517 159058 102465 70666404
Osteoarthritis 128.75 15.72 10 159565 74137 70694732
Persecutory delusion 127.53 15.72 95 159480 4422 70764447
Plasma cell myeloma 126.75 15.72 10 159565 73191 70695678
Herpes zoster 126.64 15.72 20 159555 85215 70683654
Blood prolactin increased 122.04 15.72 86 159489 3668 70765201
Circulatory collapse 119.96 15.72 254 159321 35220 70733649
Hyperprolactinaemia 118.35 15.72 90 159485 4323 70764546
Sopor 117.68 15.72 234 159341 31033 70737836
Electroencephalogram abnormal 116.85 15.72 96 159479 5162 70763707
Hypokalaemia 116.19 15.72 76 159499 131112 70637757
Maternal exposure during pregnancy 114.73 15.72 58 159517 115287 70653582
Megacolon 113.66 15.72 77 159498 3079 70765790
Haematochezia 113.57 15.72 15 159560 73066 70695803
Seizure 113.44 15.72 737 158838 177225 70591644
International normalised ratio increased 113.26 15.72 22 159553 80704 70688165
Bronchitis 110.69 15.72 63 159512 117180 70651689
Psychiatric evaluation 110.44 15.72 23 159552 8 70768861
Oedema 109.30 15.72 48 159527 103533 70665336
Wrong patient received product 108.47 15.72 86 159489 4394 70764475
Freezing phenomenon 108.45 15.72 59 159516 1575 70767294
Parkinsonism 108.02 15.72 152 159423 15173 70753696
Dizziness 107.99 15.72 608 158967 463533 70305336
Oculogyric crisis 107.24 15.72 70 159505 2628 70766241
General physical condition abnormal 106.73 15.72 96 159479 5840 70763029
Stoma site discharge 106.46 15.72 60 159515 1719 70767150
Hepatic enzyme increased 104.91 15.72 119 159456 156871 70611998
Chills 104.30 15.72 103 159472 144683 70624186
Neoplasm malignant 104.29 15.72 212 159363 28562 70740307
Left ventricular hypertrophy 103.13 15.72 121 159454 10081 70758788
Constipation 102.52 15.72 941 158634 251497 70517372
Wheezing 101.99 15.72 42 159533 94128 70674741
Drug ineffective 101.29 15.72 1498 158077 938254 69830615
Treatment failure 101.04 15.72 105 159470 144037 70624832
Lung cancer metastatic 99.24 15.72 73 159502 3332 70765537
Lower respiratory tract infection 99.16 15.72 506 159069 111407 70657462
Migraine 98.61 15.72 21 159554 72217 70696652
Rash pruritic 97.71 15.72 13 159562 62978 70705891
Chest discomfort 97.30 15.72 82 159493 124299 70644570
Drug monitoring procedure incorrectly performed 96.25 15.72 36 159539 381 70768488
Mucosal inflammation 96.23 15.72 18 159557 67832 70701037
Fibromyalgia 94.00 15.72 3 159572 47871 70720998
Left ventricular dysfunction 93.85 15.72 155 159420 17802 70751067
Irritable bowel syndrome 93.79 15.72 5 159570 50845 70718024
Muscular weakness 92.27 15.72 105 159470 138231 70630638
Inappropriate schedule of product administration 91.64 15.72 65 159510 107490 70661379
Gastrointestinal disorder 90.76 15.72 63 159512 105364 70663505
Renal failure 89.05 15.72 182 159393 188888 70579981
Gastrointestinal haemorrhage 88.75 15.72 107 159468 137301 70631568
Thrombosis 87.73 15.72 30 159545 75375 70693494
Red cell distribution width increased 86.83 15.72 129 159446 13528 70755341
Dyspepsia 86.78 15.72 46 159529 89031 70679838
Stoma site erythema 86.29 15.72 48 159527 1340 70767529
Metabolic syndrome 85.84 15.72 59 159516 2416 70766453
Hypoglycaemia 85.83 15.72 53 159522 94311 70674558
Weight decreased 85.69 15.72 383 159192 310105 70458764
Dyspnoea exertional 84.90 15.72 35 159540 78395 70690474
Intestinal pseudo-obstruction 84.27 15.72 57 159518 2273 70766596
Electrocardiogram abnormal 84.05 15.72 132 159443 14532 70754337
Nasal congestion 83.90 15.72 22 159553 65650 70703219
Abdominal pain 83.43 15.72 441 159134 341686 70427183
Folliculitis 82.41 15.72 3 159572 42567 70726302
Monocyte count decreased 81.54 15.72 62 159513 2977 70765892
Fluid retention 81.42 15.72 21 159554 63364 70705505
Bradykinesia 80.91 15.72 92 159483 7410 70761459
Blood urea decreased 80.09 15.72 60 159515 2817 70766052
Bone pain 80.01 15.72 10 159565 50812 70718057
Blood triglycerides increased 79.88 15.72 152 159423 19512 70749357
Urinary incontinence 79.84 15.72 226 159349 37616 70731253
Dysgeusia 79.76 15.72 9 159566 49493 70719376
Terminal state 79.27 15.72 73 159502 4579 70764290
Neck pain 78.45 15.72 26 159549 66631 70702238
Bradycardia 78.41 15.72 99 159476 124516 70644353
Refusal of treatment by patient 78.30 15.72 96 159479 8374 70760495
Pulmonary valve incompetence 78.23 15.72 49 159526 1711 70767158
Loss of personal independence in daily activities 78.19 15.72 47 159528 84863 70684006
Therapy cessation 77.88 15.72 208 159367 33468 70735401
Medication error 77.68 15.72 293 159282 56619 70712250
Hypothermia 77.34 15.72 154 159421 20440 70748429
Rebound psychosis 77.15 15.72 25 159550 165 70768704
Troponin I increased 76.96 15.72 68 159507 4040 70764829
Musculoskeletal stiffness 76.80 15.72 134 159441 147626 70621243
Congestive cardiomyopathy 76.46 15.72 108 159467 10818 70758051
Flushing 76.35 15.72 45 159530 82127 70686742
Pain in jaw 76.25 15.72 5 159570 42664 70726205
Red blood cell count increased 75.61 15.72 66 159509 3858 70765011
Ileus 75.61 15.72 168 159407 24069 70744800
Thinking abnormal 75.43 15.72 113 159462 11938 70756931
Vomiting 75.09 15.72 914 158661 592197 70176672
Polyserositis 74.91 15.72 33 159542 547 70768322
Visual impairment 74.49 15.72 44 159531 80206 70688663
Tobacco interaction 74.39 15.72 20 159555 60 70768809
Impaired self-care 74.38 15.72 53 159522 2301 70766568
Blood pressure increased 73.19 15.72 201 159374 188316 70580553
Neutrophil count abnormal 72.95 15.72 59 159516 3102 70765767
Body temperature increased 72.72 15.72 226 159349 39608 70729261
Delusion of grandeur 72.26 15.72 37 159538 870 70767999
Swelling face 71.99 15.72 26 159549 63138 70705731
Hypertension 71.36 15.72 383 159192 295650 70473219
Posture abnormal 70.33 15.72 61 159514 3535 70765334
Obesity 69.81 15.72 173 159402 26598 70742271
Suspiciousness 69.75 15.72 32 159543 586 70768283
Rhinorrhoea 69.63 15.72 31 159544 66340 70702529
Dry skin 69.08 15.72 20 159555 55911 70712958
Cerebral haemorrhage 68.89 15.72 18 159557 53846 70715023
Multiple sclerosis relapse 68.86 15.72 8 159567 43009 70725860
Lactic acidosis 68.80 15.72 30 159545 64994 70703875
Ascites 68.62 15.72 33 159542 67514 70701355
Angioedema 68.50 15.72 32 159543 66578 70702291
Haematoma 68.33 15.72 13 159562 48405 70720464
Acute psychosis 67.80 15.72 62 159513 3854 70765015
Hepatitis C 67.54 15.72 111 159464 12696 70756173
Waxy flexibility 67.40 15.72 25 159550 258 70768611
Thrombocytopenia 67.29 15.72 828 158747 238282 70530587
Cytomegalovirus infection 67.26 15.72 6 159569 39752 70729117
Osteoporosis 67.20 15.72 14 159561 48893 70719976
Apathy 66.60 15.72 106 159469 11802 70757067
Colitis ischaemic 65.93 15.72 116 159459 14021 70754848
Bundle branch block right 65.71 15.72 99 159476 10511 70758358
Basophil count increased 65.54 15.72 40 159535 1333 70767536
Asthma 65.11 15.72 107 159468 120686 70648183
Cardiac failure congestive 64.95 15.72 129 159446 135328 70633541
Exposure during pregnancy 64.79 15.72 61 159514 87656 70681213
Insomnia 64.77 15.72 261 159314 217545 70551324
Electrocardiogram T wave abnormal 64.53 15.72 57 159518 3385 70765484
Rash maculo-papular 64.44 15.72 17 159558 50528 70718341
Rectal haemorrhage 64.11 15.72 34 159541 65797 70703072
Intestinal dilatation 64.10 15.72 48 159527 2252 70766617
Coma scale abnormal 64.00 15.72 85 159490 8031 70760838
Myocardial fibrosis 63.96 15.72 42 159533 1593 70767276
Diverticulitis 63.81 15.72 9 159566 41725 70727144
Insurance issue 63.45 15.72 58 159517 3603 70765266
Burning sensation 63.32 15.72 20 159555 52850 70716019
Cataract 63.25 15.72 23 159552 55622 70713247
Haematuria 63.15 15.72 32 159543 63541 70705328
Overweight 62.84 15.72 57 159518 3506 70765363
Monocytosis 62.78 15.72 32 159543 745 70768124
Epilepsy 62.62 15.72 211 159364 38573 70730296
Tinnitus 62.46 15.72 5 159570 36171 70732698
Social avoidant behaviour 62.32 15.72 64 159511 4592 70764277
Arteriosclerosis coronary artery 61.79 15.72 122 159453 16093 70752776
Pseudophaeochromocytoma 61.65 15.72 18 159557 79 70768790
Schizoaffective disorder bipolar type 61.32 15.72 21 159554 168 70768701
Hypocalcaemia 61.31 15.72 13 159562 44846 70724023
Vision blurred 61.28 15.72 74 159501 94910 70673959
Dysphemia 61.11 15.72 54 159521 3209 70765660
Dysarthria 61.05 15.72 290 159285 62023 70706846
Eye pain 60.92 15.72 4 159571 34098 70734771
Mutism 60.85 15.72 45 159530 2071 70766798
Throat irritation 60.62 15.72 5 159570 35299 70733570
Basal cell carcinoma 60.06 15.72 4 159571 33694 70735175
Skin ulcer 59.86 15.72 17 159558 48128 70720741
Skin lesion 59.50 15.72 8 159567 38452 70730417
Rash erythematous 59.43 15.72 21 159554 51697 70717172
Obsessive-compulsive symptom 59.16 15.72 21 159554 189 70768680
Heart rate decreased 58.98 15.72 33 159542 61982 70706887
Echocardiogram abnormal 58.97 15.72 43 159532 1936 70766933
Hot flush 58.95 15.72 19 159556 49565 70719304
Feeling abnormal 58.85 15.72 147 159428 142172 70626697
Hyperkinesia 58.52 15.72 48 159527 2575 70766294
Imprisonment 57.43 15.72 27 159548 524 70768345
Hypomagnesaemia 57.40 15.72 11 159564 40753 70728116
Muscle injury 57.25 15.72 9 159566 38485 70730384
Intentional self-injury 57.25 15.72 179 159396 31471 70737398
Swollen tongue 56.62 15.72 8 159567 37038 70731831
Drug reaction with eosinophilia and systemic symptoms 56.44 15.72 30 159545 57983 70710886
Skin exfoliation 55.44 15.72 20 159555 48606 70720263
Hyponatraemia 55.42 15.72 180 159395 159907 70608962
Dehydration 55.35 15.72 291 159284 225851 70543018
Mania 54.65 15.72 120 159455 17054 70751815
Lymphocyte percentage increased 54.19 15.72 27 159548 598 70768271
Cholestasis 54.05 15.72 20 159555 47852 70721017
Depression 53.31 15.72 248 159327 198726 70570143
Renal impairment 53.25 15.72 157 159418 143780 70625089
Electrocardiogram T wave inversion 53.08 15.72 61 159514 4970 70763899
Nephrolithiasis 53.05 15.72 20 159555 47303 70721566
Diabetes mellitus 52.33 15.72 308 159267 71516 70697353
Gastrointestinal necrosis 52.23 15.72 61 159514 5057 70763812
Malaise 51.71 15.72 1307 158268 431625 70337244
Body mass index increased 51.67 15.72 38 159537 1734 70767135
Lymphoma 51.44 15.72 110 159465 15352 70753517
Withdrawal catatonia 51.30 15.72 18 159557 156 70768713
Polydipsia psychogenic 51.23 15.72 19 159556 196 70768673
Akinesia 51.16 15.72 48 159527 3083 70765786
Suicidal ideation 51.06 15.72 299 159276 69297 70699572
Fibroma 51.05 15.72 27 159548 680 70768189
Neutrophil count normal 50.99 15.72 10 159565 0 70768869
Haemoptysis 50.95 15.72 26 159549 51426 70717443
Pancytopenia 50.86 15.72 172 159403 150935 70617934
Lip swelling 50.56 15.72 8 159567 34046 70734823
Gastrooesophageal reflux disease 50.33 15.72 79 159496 90760 70678109
Haematocrit increased 49.98 15.72 51 159524 3631 70765238
Subileus 49.55 15.72 60 159515 5167 70763702
Dry eye 49.27 15.72 7 159568 32275 70736594
C-reactive protein abnormal 49.13 15.72 13 159562 38566 70730303
Cystitis 49.12 15.72 22 159553 46919 70721950
Stoma site inflammation 48.74 15.72 25 159550 590 70768279
Hepatotoxicity 48.63 15.72 19 159556 43967 70724902
Hallucination, visual 48.60 15.72 161 159414 29176 70739693
Mobility decreased 48.59 15.72 99 159476 102900 70665969
COVID-19 48.44 15.72 405 159170 105352 70663517
Haemorrhage 48.26 15.72 71 159504 83744 70685125
Melaena 48.07 15.72 34 159541 56321 70712548
Bursitis 48.03 15.72 3 159572 26670 70742199
Restlessness 47.97 15.72 205 159370 41923 70726946
Pneumonitis 47.82 15.72 32 159543 54565 70714304
Negativism 47.73 15.72 27 159548 779 70768090
Mean cell haemoglobin increased 47.62 15.72 49 159526 3524 70765345
Hypervolaemia 47.58 15.72 15 159560 39691 70729178
Mean cell haemoglobin concentration increased 47.36 15.72 27 159548 791 70768078
Blood pressure systolic increased 46.95 15.72 36 159539 57223 70711646
Globulins decreased 46.87 15.72 21 159554 363 70768506
Gamma-glutamyltransferase increased 46.86 15.72 232 159343 50453 70718416
Malignant catatonia 46.75 15.72 22 159553 428 70768441
Skin discolouration 46.74 15.72 13 159562 37312 70731557
Ejection fraction decreased 46.73 15.72 164 159411 30598 70738271
Joint range of motion decreased 46.65 15.72 3 159572 26023 70742846
Joint stiffness 46.45 15.72 11 159564 35165 70733704
Delusional disorder, unspecified type 46.38 15.72 26 159549 737 70768132
Therapeutic product effect variable 46.13 15.72 35 159540 1675 70767194
Clostridium difficile infection 45.92 15.72 15 159560 38801 70730068
Tricuspid valve incompetence 45.26 15.72 114 159461 17703 70751166
Cerebral infarction 45.25 15.72 20 159555 42989 70725880
Hepatic failure 45.04 15.72 38 159537 57587 70711282
Acne 44.44 15.72 3 159572 24986 70743883
Dry mouth 44.28 15.72 56 159519 70401 70698468
Ill-defined disorder 44.15 15.72 35 159540 54706 70714163
Neuralgia 44.13 15.72 6 159569 28597 70740272
Colitis ulcerative 44.03 15.72 11 159564 33912 70734957
Condition aggravated 43.97 15.72 687 158888 426948 70341921
Toxic epidermal necrolysis 43.87 15.72 17 159558 39540 70729329
QRS axis abnormal 43.58 15.72 35 159540 1822 70767047
Posterior reversible encephalopathy syndrome 43.19 15.72 3 159572 24399 70744470
Candida infection 43.18 15.72 12 159563 34461 70734408
Polydipsia 43.10 15.72 60 159515 5928 70762941
Hepatitis C virus test positive 43.07 15.72 19 159556 316 70768553
Osteonecrosis 42.95 15.72 7 159568 29153 70739716
Haemorrhoids 42.91 15.72 4 159571 25584 70743285
Dementia 42.79 15.72 129 159446 22236 70746633
Oral pain 42.76 15.72 7 159568 29059 70739810
Oral herpes 42.73 15.72 3 159572 24183 70744686
Device related infection 42.63 15.72 10 159565 32175 70736694
Productive cough 42.57 15.72 69 159506 78268 70690601
Coronavirus infection 42.57 15.72 61 159514 6191 70762678
Nervousness 42.56 15.72 9 159566 31111 70737758
Affective disorder 42.41 15.72 67 159508 7412 70761457
Neutrophil count 42.39 15.72 16 159559 174 70768695
Fungal infection 41.72 15.72 16 159559 37451 70731418
Dysphonia 41.72 15.72 31 159544 50069 70718800
Angina pectoris 41.51 15.72 29 159546 48354 70720515
Haemorrhage intracranial 41.21 15.72 4 159571 24773 70744096
Upper respiratory tract infection 41.08 15.72 72 159503 79202 70689667
Knee arthroplasty 41.03 15.72 13 159562 34288 70734581
Anion gap increased 40.88 15.72 43 159532 3173 70765696
Foreign body ingestion 40.79 15.72 8 159567 0 70768869
Wrong technique in product usage process 40.73 15.72 57 159518 68641 70700228
Tooth disorder 39.46 15.72 4 159571 23934 70744935
Feeling hot 39.40 15.72 31 159544 48639 70720230
Disinhibition 39.00 15.72 36 159539 2265 70766604
Neoplasm progression 38.95 15.72 27 159548 45201 70723668
Pancreatic fibrosis 38.86 15.72 13 159562 96 70768773
Drug dose titration not performed 38.52 15.72 23 159552 736 70768133
Blood bilirubin decreased 38.45 15.72 25 159550 932 70767937
Psychomotor hyperactivity 38.42 15.72 98 159477 15335 70753534
Visual acuity reduced 38.36 15.72 8 159567 27922 70740947
Lymphadenopathy 38.34 15.72 32 159543 48759 70720110
Stoma site irritation 37.59 15.72 16 159559 243 70768626
Drug eruption 37.58 15.72 21 159554 39475 70729394
Catecholamines urine increased 37.48 15.72 9 159566 14 70768855
Rebound effect 37.39 15.72 56 159519 5915 70762954
Palpitations 37.31 15.72 126 159449 110627 70658242
Throat tightness 36.87 15.72 6 159569 25016 70743853
Gastrointestinal carcinoma 36.85 15.72 39 159536 2898 70765971
Oxygen saturation decreased 36.85 15.72 136 159439 116293 70652576
Diplopia 36.78 15.72 9 159566 28138 70740731
Pneumocystis jirovecii pneumonia 36.70 15.72 11 159564 30071 70738798
Ventricular tachycardia 36.68 15.72 18 159557 36405 70732464
Hip arthroplasty 36.57 15.72 9 159566 28031 70740838
Obsessive thoughts 36.50 15.72 25 159550 1018 70767851
Stupor 36.48 15.72 58 159517 6451 70762418
Inappropriate affect 36.44 15.72 28 159547 1366 70767503
Joint injury 36.40 15.72 8 159567 26924 70741945
Blood disorder 36.39 15.72 61 159514 7091 70761778
Ocular hyperaemia 36.10 15.72 6 159569 24633 70744236
Device expulsion 35.95 15.72 4 159571 22242 70746627
Coagulopathy 35.71 15.72 15 159560 33234 70735635
Cervix neoplasm 35.27 15.72 14 159561 176 70768693
Liver function test increased 35.20 15.72 16 159559 33831 70735038
Spleen congestion 35.01 15.72 18 159557 427 70768442
Injury 34.96 15.72 58 159517 65187 70703682
Echolalia 34.69 15.72 17 159558 363 70768506
Blunted affect 34.59 15.72 18 159557 438 70768431
Intentional overdose 34.51 15.72 356 159219 98079 70670790
Coronary artery disease 34.33 15.72 55 159520 62681 70706188
Hyperbilirubinaemia 34.19 15.72 5 159570 22563 70746306
Visceral congestion 33.80 15.72 22 159553 822 70768047
Chronic obstructive pulmonary disease 33.79 15.72 294 159281 77347 70691522
Myelosuppression 33.36 15.72 13 159562 30132 70738737
Seminoma 33.23 15.72 14 159561 207 70768662
Hypercalcaemia 33.13 15.72 18 159557 34367 70734502
Gastric ulcer 33.10 15.72 15 159560 31775 70737094
Stoma site reaction 33.06 15.72 16 159559 332 70768537
Pulmonary fibrosis 33.00 15.72 18 159557 34292 70734577
Central obesity 32.99 15.72 28 159547 1575 70767294
Postmortem blood drug level increased 32.81 15.72 21 159554 762 70768107
Ventricular hypokinesia 32.76 15.72 63 159512 8149 70760720
Eosinophilic colitis 32.66 15.72 17 159558 414 70768455
Parkinsonism hyperpyrexia syndrome 32.63 15.72 14 159561 217 70768652
Intestinal ischaemia 32.55 15.72 79 159496 11985 70756884
Delusional disorder, persecutory type 32.47 15.72 17 159558 419 70768450
Localised infection 32.47 15.72 17 159558 33141 70735728
Drug level fluctuating 32.43 15.72 20 159555 679 70768190
Vertigo 32.36 15.72 57 159518 62586 70706283
Blood lactate dehydrogenase decreased 32.15 15.72 15 159560 286 70768583
Blood pressure fluctuation 32.04 15.72 52 159523 58960 70709909
Product use issue 32.04 15.72 255 159320 179682 70589187
Faecal vomiting 31.89 15.72 23 159552 1018 70767851
Impulsive behaviour 31.80 15.72 35 159540 2719 70766150
Deep vein thrombosis 31.78 15.72 135 159440 110907 70657962
Cellulitis 31.67 15.72 115 159460 98813 70670056
Ischaemic stroke 31.38 15.72 15 159560 30805 70738064
Hypersplenism 31.38 15.72 17 159558 450 70768419
Blood creatinine decreased 31.33 15.72 58 159517 7291 70761578
Jaundice 31.30 15.72 40 159535 50068 70718801
Gastric disorder 31.30 15.72 18 159557 33304 70735565
Electroconvulsive therapy 31.28 15.72 11 159564 96 70768773
Musculoskeletal disorder 31.26 15.72 4 159571 19967 70748902
Behaviour disorder 31.05 15.72 49 159526 5415 70763454
Product quality issue 30.93 15.72 15 159560 30546 70738323
Radiation inflammation 30.89 15.72 18 159557 550 70768319
Drug level changed 30.86 15.72 18 159557 551 70768318
High density lipoprotein decreased 30.74 15.72 42 159533 4077 70764792
Investigation noncompliance 30.60 15.72 6 159569 0 70768869
Unresponsive to stimuli 30.58 15.72 211 159364 51720 70717149
Cardiac steatosis 30.55 15.72 9 159566 41 70768828
Femur fracture 30.55 15.72 22 159553 36110 70732759
Musculoskeletal chest pain 30.52 15.72 7 159568 22874 70745995
Blood osmolarity increased 30.49 15.72 18 159557 564 70768305
Injection site mass 30.41 15.72 3 159572 18340 70750529
Ear pain 30.38 15.72 12 159563 27587 70741282
Ideas of reference 30.37 15.72 12 159563 149 70768720
Pulmonary hypertension 30.28 15.72 36 159539 46500 70722369
Hepatic steatosis 30 15.72 153 159422 33660 70735209
Shock haemorrhagic 29.91 15.72 3 159572 18103 70750766
Glaucoma 29.89 15.72 3 159572 18089 70750780
Abdominal pain lower 29.87 15.72 13 159562 28203 70740666
Electrocardiogram T wave amplitude decreased 29.81 15.72 18 159557 588 70768281
Clostridium difficile colitis 29.70 15.72 14 159561 28982 70739887
Lymphocytosis 29.54 15.72 40 159535 3850 70765019
Encephalitis toxic 29.44 15.72 14 159561 279 70768590
Limb discomfort 29.43 15.72 15 159560 29690 70739179
Loss of consciousness 29.35 15.72 503 159072 155213 70613656
Night sweats 29.28 15.72 33 159542 43651 70725218
Blindness 29.25 15.72 8 159567 23219 70745650
Dilatation ventricular 29.21 15.72 40 159535 3891 70764978
Dysuria 29.19 15.72 36 159539 45758 70723111
Frequent bowel movements 29.17 15.72 6 159569 21147 70747722
Metamyelocyte count increased 29.11 15.72 18 159557 614 70768255
Drug-induced liver injury 29.04 15.72 51 159524 56062 70712807
Disseminated intravascular coagulation 29.01 15.72 20 159555 33578 70735291
Monocyte percentage increased 28.99 15.72 29 159546 2016 70766853
Transfusion 28.94 15.72 4 159571 18832 70750037
Blood alkaline phosphatase increased 28.89 15.72 228 159347 58293 70710576
Confusional state 28.88 15.72 841 158734 283557 70485312
Flatulence 28.84 15.72 26 159549 38155 70730714
Gout 28.83 15.72 8 159567 22998 70745871
Acute myocardial infarction 28.80 15.72 77 159498 72810 70696059
Limb injury 28.67 15.72 11 159564 25741 70743128
Incontinence 28.65 15.72 79 159496 12949 70755920
Bone disorder 28.63 15.72 3 159572 17487 70751382
Eye disorder 28.45 15.72 6 159569 20779 70748090
Parkinson's disease 28.34 15.72 27 159548 1768 70767101
Thought blocking 27.97 15.72 12 159563 186 70768683
Self-injurious ideation 27.94 15.72 36 159539 3302 70765567
Patient restraint 27.69 15.72 10 159565 95 70768774
Toxicity to various agents 27.60 15.72 1086 158489 381086 70387783
Cardiomegaly 27.60 15.72 119 159456 24426 70744443
Osteomyelitis 27.60 15.72 17 159558 30301 70738568
Neutrophil percentage increased 27.59 15.72 42 159533 4500 70764369
Liver disorder 27.51 15.72 61 159514 61507 70707362
Left atrial dilatation 27.49 15.72 33 159542 2816 70766053
Cardiac disorder 27.44 15.72 228 159347 59187 70709682
Withdrawal syndrome 27.44 15.72 120 159455 24784 70744085
Volvulus 27.28 15.72 30 159545 2328 70766541
Procedural pain 27.26 15.72 4 159571 18005 70750864
Suicidal behaviour 27.22 15.72 34 159541 3022 70765847
Torticollis 27.13 15.72 29 159546 2180 70766689
Ulcer 27.05 15.72 12 159563 25742 70743127
Musculoskeletal discomfort 26.90 15.72 4 159571 17828 70751041
Bone marrow failure 26.79 15.72 43 159532 48967 70719902
Testicular germ cell cancer metastatic 26.73 15.72 9 159566 68 70768801
Lacrimation increased 26.72 15.72 6 159569 19893 70748976
Testicular atrophy 26.71 15.72 14 159561 346 70768523
Incoherent 26.67 15.72 54 159521 7252 70761617
Red cell distribution width decreased 26.67 15.72 25 159550 1604 70767265
Heart rate increased 26.61 15.72 360 159215 105788 70663081
Product prescribing error 26.58 15.72 29 159546 38923 70729946
Excessive masturbation 26.39 15.72 9 159566 71 70768798
Aortic dilatation 26.34 15.72 25 159550 1629 70767240
Judgement impaired 26.31 15.72 21 159554 1083 70767786
Skin disorder 26.30 15.72 18 159557 30339 70738530
Obstructive airways disorder 26.15 15.72 13 159562 26100 70742769
B-cell lymphoma 26.13 15.72 49 159526 6220 70762649
Neutrophil percentage decreased 26.10 15.72 18 159557 741 70768128
Dementia with Lewy bodies 26.06 15.72 18 159557 743 70768126
Myelocyte count increased 25.93 15.72 18 159557 749 70768120
Mitral valve incompetence 25.89 15.72 124 159451 26604 70742265
Lethargy 25.83 15.72 271 159304 74979 70693890
Blood osmolarity decreased 25.75 15.72 22 159553 1249 70767620
Eosinophilic pleural effusion 25.69 15.72 13 159562 298 70768571
SARS-CoV-2 test positive 25.67 15.72 59 159516 8642 70760227
Protein total decreased 25.59 15.72 57 159518 8179 70760690
Eosinopenia 25.48 15.72 8 159567 47 70768822
Presyncope 25.40 15.72 28 159547 37410 70731459
Blood urea nitrogen/creatinine ratio decreased 25.35 15.72 9 159566 81 70768788
Hypoacusis 25.23 15.72 15 159560 27254 70741615
Prostate cancer 25.03 15.72 20 159555 31143 70737726
Serositis 25.01 15.72 18 159557 794 70768075
Purpura 24.99 15.72 5 159570 17970 70750899
Brain injury 24.97 15.72 66 159509 10551 70758318
Anisocytosis 24.94 15.72 19 159556 915 70767954
Nodule 24.92 15.72 7 159568 19962 70748907
Chronic hepatitis C 24.79 15.72 16 159559 589 70768280
Therapeutic product effect incomplete 24.66 15.72 163 159412 119719 70649150
Depressed level of consciousness 24.65 15.72 303 159272 87128 70681741
Bacteraemia 24.58 15.72 18 159557 29291 70739578
Drug level above therapeutic 24.52 15.72 54 159521 7688 70761181
Disturbance in attention 24.50 15.72 173 159402 42721 70726148
Thrombocytosis 24.32 15.72 54 159521 7730 70761139
Photophobia 24.29 15.72 6 159569 18644 70750225
Abnormal clotting factor 24.23 15.72 10 159565 140 70768729
Blood folate decreased 24.23 15.72 21 159554 1216 70767653
Spinal osteoarthritis 24.20 15.72 3 159572 15345 70753524
Testicular cancer metastatic 24.16 15.72 8 159567 57 70768812
Neurotoxicity 24.14 15.72 19 159556 29807 70739062
Lung disorder 24.12 15.72 78 159497 69406 70699463
Myelodysplastic syndrome 24.07 15.72 19 159556 29766 70739103
Coma 24.06 15.72 314 159261 91530 70677339
Flank pain 24.06 15.72 5 159570 17497 70751372
Electrocardiogram ST segment elevation 24.04 15.72 53 159522 7551 70761318
Reduced facial expression 23.94 15.72 28 159547 2324 70766545
Compulsions 23.90 15.72 13 159562 347 70768522
Impaired work ability 23.89 15.72 4 159571 16336 70752533
Premature delivery 23.88 15.72 9 159566 21295 70747574
Haemodialysis 23.79 15.72 5 159570 17361 70751508
Photosensitivity reaction 23.73 15.72 7 159568 19333 70749536
Influenza 23.69 15.72 154 159421 113546 70655323
Ventricular fibrillation 23.59 15.72 16 159559 27095 70741774
Creatinine renal clearance decreased 23.47 15.72 5 159570 17195 70751674
Drug titration error 23.41 15.72 19 159556 1004 70767865
Eosinophilic myocarditis 23.41 15.72 18 159557 879 70767990
Cogwheel rigidity 23.27 15.72 31 159544 2937 70765932
Tangentiality 23.13 15.72 10 159565 158 70768711
Drug dependence 23.10 15.72 30 159545 37291 70731578
Disorientation 22.98 15.72 215 159360 57708 70711161
Grandiosity 22.93 15.72 15 159560 565 70768304
Red blood cell elliptocytes present 22.80 15.72 10 159565 164 70768705
Hypophagia 22.79 15.72 166 159409 41404 70727465
Blood sodium increased 22.69 15.72 38 159537 4414 70764455
Sudden cardiac death 22.67 15.72 40 159535 4845 70764024
Mean platelet volume increased 22.63 15.72 19 159556 1053 70767816
Muscle spasticity 22.61 15.72 8 159567 19681 70749188
Systolic dysfunction 22.44 15.72 33 159542 3428 70765441
Total cholesterol/HDL ratio increased 22.44 15.72 11 159564 235 70768634
Right ventricular failure 22.44 15.72 11 159564 22263 70746606
Oropharyngeal pain 22.40 15.72 126 159449 96184 70672685
Blood bicarbonate decreased 22.34 15.72 40 159535 4901 70763968
Rash macular 22.33 15.72 15 159560 25529 70743340
Upper gastrointestinal haemorrhage 22.31 15.72 31 159544 37446 70731423
Granulocytosis 22.20 15.72 12 159563 316 70768553
Diet refusal 22.18 15.72 17 159558 826 70768043
Blood creatinine increased 22.18 15.72 210 159365 142791 70626078
Ecchymosis 22.12 15.72 3 159572 14329 70754540
Somatic dysfunction 22.08 15.72 6 159569 19 70768850
Blood creatine phosphokinase decreased 22.04 15.72 17 159558 834 70768035
Cardiac arrest 21.89 15.72 492 159083 159342 70609527
Eye swelling 21.83 15.72 13 159562 23601 70745268
Euphoric mood 21.76 15.72 48 159527 6841 70762028
Product administration error 21.75 15.72 127 159448 29396 70739473
Poor personal hygiene 21.73 15.72 14 159561 514 70768355
Skin necrosis 21.70 15.72 5 159570 16286 70752583
Gait inability 21.69 15.72 46 159529 47129 70721740
Anticholinergic syndrome 21.66 15.72 30 159545 2950 70765919
Globulin abnormal 21.57 15.72 5 159570 6 70768863
Skin reaction 21.55 15.72 3 159572 14046 70754823
Eye movement disorder 21.46 15.72 50 159525 7390 70761479
Flat affect 21.45 15.72 24 159551 1899 70766970
Staphylococcal infection 21.41 15.72 56 159519 53348 70715521
Tension 21.38 15.72 35 159540 3989 70764880
Intestinal infarction 21.35 15.72 20 159555 1282 70767587
Water intoxication 21.32 15.72 16 159559 753 70768116
Hyperosmolar state 21.32 15.72 15 159560 638 70768231
Left ventricular dilatation 21.25 15.72 18 159557 1010 70767859
Disability 21.19 15.72 4 159571 14979 70753890
Face oedema 21.17 15.72 16 159559 25623 70743246
Influenza B virus test positive 21.13 15.72 12 159563 349 70768520
Drop attacks 21.13 15.72 18 159557 1018 70767851
Learning disability 21.04 15.72 10 159565 199 70768670
Gender dysphoria 21.01 15.72 7 159568 51 70768818
Spinal pain 20.98 15.72 3 159572 13767 70755102
Polyneuropathy 20.94 15.72 11 159564 21404 70747465
Drowning 20.90 15.72 16 159559 776 70768093
Sedation complication 20.80 15.72 72 159503 13338 70755531
Sinus rhythm 20.77 15.72 15 159560 665 70768204
Anaemia 20.77 15.72 721 158854 402702 70366167
Pregnancy 20.74 15.72 14 159561 23767 70745102
Tobacco user 20.58 15.72 15 159560 675 70768194
Pharyngeal oedema 20.54 15.72 5 159570 15691 70753178
Hepatic function abnormal 20.49 15.72 81 159494 67915 70700954
White blood cell disorder 20.42 15.72 29 159546 2919 70765950
Cholinergic rebound syndrome 20.40 15.72 4 159571 0 70768869
High-grade B-cell lymphoma 20.38 15.72 10 159565 214 70768655
Balance disorder 20.37 15.72 119 159456 90009 70678860
Blood urine present 20.36 15.72 9 159566 19344 70749525
Syncope 20.25 15.72 257 159318 165452 70603417
Blood pressure diastolic decreased 20.14 15.72 17 159558 25763 70743106
Acute coronary syndrome 20.10 15.72 10 159565 20069 70748800
Dermatitis allergic 20.06 15.72 6 159569 16425 70752444
Acute myeloid leukaemia 20.06 15.72 24 159551 30916 70737953
Petechiae 20.03 15.72 9 159566 19163 70749706
Amnesia 19.93 15.72 56 159519 52099 70716770
Proteinuria 19.89 15.72 22 159553 29352 70739517
Device malfunction 19.88 15.72 9 159566 19075 70749794
Liver injury 19.72 15.72 39 159536 40996 70727873
Necrotising colitis 19.71 15.72 17 159558 978 70767891
Bipolar disorder 19.66 15.72 49 159526 7559 70761310
Full blood count decreased 19.65 15.72 15 159560 23903 70744966
Gingival bleeding 19.65 15.72 5 159570 15227 70753642
Stoma site extravasation 19.58 15.72 11 159564 313 70768556
Blood albumin decreased 19.54 15.72 100 159475 22027 70746842
Memory impairment 19.54 15.72 125 159450 92516 70676353
Priapism 19.52 15.72 34 159541 4076 70764793
Rib fracture 19.47 15.72 17 159558 25339 70743530
Loss of libido 19.46 15.72 26 159549 2471 70766398
Prescribed underdose 19.45 15.72 12 159563 21373 70747496
Amylase decreased 19.41 15.72 9 159566 169 70768700
Posturing 19.34 15.72 17 159558 1003 70767866
Cognitive disorder 19.28 15.72 216 159359 60740 70708129
Chromaturia 19.02 15.72 15 159560 23513 70745356
Microcytosis 19 15.72 11 159564 332 70768537
Blood bilirubin increased 18.93 15.72 70 159505 59831 70709038
Oral candidiasis 18.83 15.72 17 159558 24935 70743934
Norepinephrine increased 18.81 15.72 7 159568 73 70768796
Deafness 18.75 15.72 10 159565 19293 70749576
Viral myocarditis 18.73 15.72 12 159563 436 70768433
Complication associated with device 18.71 15.72 6 159569 15707 70753162
Left atrial enlargement 18.69 15.72 17 159558 1049 70767820
Transferrin saturation decreased 18.69 15.72 16 159559 911 70767958
Grip strength decreased 18.66 15.72 6 159569 15679 70753190
Delusional perception 18.65 15.72 11 159564 344 70768525
Stoma site discomfort 18.65 15.72 8 159567 124 70768745
Hallucinations, mixed 18.62 15.72 43 159532 6319 70762550
Haematotoxicity 18.61 15.72 4 159571 13670 70755199
Life support 18.59 15.72 12 159563 442 70768427
Chest pain 18.55 15.72 427 159148 250833 70518036
Blood pressure decreased 18.53 15.72 125 159450 91390 70677479
Cardiac septal hypertrophy 18.48 15.72 10 159565 264 70768605
Stoma site pain 18.47 15.72 18 159557 1212 70767657
Enterococcal infection 18.40 15.72 5 159570 14577 70754292
Electrocardiogram ST-T change 18.29 15.72 20 159555 1542 70767327
Inflammation 18.24 15.72 103 159472 78562 70690307
Paraneoplastic rash 18.23 15.72 7 159568 80 70768789
Poverty of speech 18.21 15.72 13 159562 566 70768303
Blood test abnormal 18.18 15.72 73 159502 14517 70754352
Hypoxia 18.16 15.72 129 159446 93215 70675654
Small intestinal obstruction 18.12 15.72 106 159469 24549 70744320
Drug level decreased 18.06 15.72 66 159509 12558 70756311
Blood phosphorus increased 17.91 15.72 44 159531 6726 70762143
Cervix cancer metastatic 17.91 15.72 5 159570 18 70768851
Compensatory sweating 17.86 15.72 6 159569 45 70768824
Soliloquy 17.81 15.72 13 159562 586 70768283
Crying 17.80 15.72 13 159562 21186 70747683
Transient ischaemic attack 17.80 15.72 49 159526 45895 70722974
Gait disturbance 17.77 15.72 301 159274 184805 70584064
Glucose tolerance impaired 17.76 15.72 44 159531 6762 70762107
Abortion spontaneous 17.75 15.72 20 159555 26459 70742410
Bronchiectasis 17.71 15.72 7 159568 16090 70752779
Gastritis 17.69 15.72 47 159528 44544 70724325
Subdural haematoma 17.67 15.72 24 159551 29274 70739595
Contraindicated product administered 17.50 15.72 206 159369 134406 70634463
Electrocardiogram QT shortened 17.49 15.72 9 159566 214 70768655
Lymphocyte morphology abnormal 17.40 15.72 15 159560 862 70768007
Nephropathy toxic 17.39 15.72 10 159565 18504 70750365
Blood cholesterol decreased 17.39 15.72 20 159555 1631 70767238
Cerebrovascular accident 17.35 15.72 223 159352 143247 70625622
Aplastic anaemia 17.23 15.72 8 159567 16708 70752161
Defect conduction intraventricular 17.21 15.72 11 159564 398 70768471
Therapy interrupted 17.19 15.72 105 159470 24697 70744172
Tonic clonic movements 17.18 15.72 22 159553 2005 70766864
Drug-disease interaction 17.17 15.72 15 159560 878 70767991
Myocardial necrosis marker increased 17.14 15.72 27 159548 2979 70765890
Hemiplegia 17.10 15.72 5 159570 13890 70754979
Atonic seizures 17.08 15.72 14 159561 750 70768119
Palliative care 17.08 15.72 14 159561 750 70768119
Cardiac failure 17.03 15.72 224 159351 143317 70625552
Thyroid disorder 16.97 15.72 4 159571 12828 70756041
Lymphocyte count abnormal 16.93 15.72 16 159559 1037 70767832
Endotracheal intubation 16.92 15.72 33 159542 4313 70764556
Nightmare 16.84 15.72 15 159560 22141 70746728
Dermatitis bullous 16.82 15.72 4 159571 12753 70756116
Alcohol problem 16.80 15.72 6 159569 55 70768814
Ankylosing spondylitis 16.70 15.72 3 159572 11643 70757226
Retrograde ejaculation 16.69 15.72 9 159566 236 70768633
Type 2 diabetes mellitus 16.69 15.72 162 159413 43918 70724951
Pulmonary haemorrhage 16.68 15.72 5 159570 13668 70755201
Laryngitis 16.60 15.72 5 159570 13626 70755243
Illness anxiety disorder 16.59 15.72 9 159566 239 70768630
Hypersexuality 16.57 15.72 19 159556 1544 70767325
Sputum discoloured 16.57 15.72 11 159564 18840 70750029
Psychotic behaviour 16.56 15.72 16 159559 1066 70767803
Physical assault 16.56 15.72 19 159556 1545 70767324
Tenderness 16.55 15.72 14 159561 21196 70747673
Repetitive speech 16.53 15.72 10 159565 328 70768541
Bladder trabeculation 16.52 15.72 6 159569 58 70768811
Hypersensitivity myocarditis 16.52 15.72 7 159568 105 70768764
Adjusted calcium increased 16.43 15.72 6 159569 59 70768810
Skin cancer 16.42 15.72 5 159570 13531 70755338
Conduction disorder 16.41 15.72 27 159548 3091 70765778
Stress 16.30 15.72 88 159487 67878 70700991
Resting tremor 16.25 15.72 18 159557 1408 70767461
Staphylococcal sepsis 16.22 15.72 5 159570 13422 70755447
Gallbladder cholesterolosis 16.19 15.72 12 159563 554 70768315
Sperm concentration decreased 16.00 15.72 6 159569 64 70768805
Hyperthermia 15.90 15.72 77 159498 16594 70752275
Crush syndrome 15.86 15.72 8 159567 182 70768687
Tongue disorder 15.84 15.72 5 159570 13222 70755647
Borderline personality disorder 15.84 15.72 14 159561 832 70768037
Oliguria 15.83 15.72 7 159568 15044 70753825
Lymphoedema 15.75 15.72 3 159572 11166 70757703
Empyema 15.73 15.72 30 159545 3857 70765012

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent
CHEBI has role CHEBI:65259 GABA antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
Histone H1.0 Nuclear other Ki 9 CHEMBL
Calmodulin-1 Cytosolic other IC50 4.70 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Alpha-1B adrenergic receptor GPCR Ki 8.45 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Transporter Transporter Ki 6.41 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 5A GPCR ANTAGONIST Ki 5.30 IUPHAR
Calmodulin Cytosolic other Kd 4.21 CHEMBL
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR

External reference:

IDSource
4019488 VUID
N0000147608 NUI
D00283 KEGG_DRUG
216102 RXNORM
4019488 VANDF
4024939 VANDF
4036908 VANDF
4037056 VANDF
4037345 VANDF
4040180 VANDF
C0009079 UMLSCUI
CHEBI:3766 CHEBI
CHEMBL42 ChEMBL_ID
CHEMBL538973 ChEMBL_ID
DB00363 DRUGBANK_ID
D003024 MESH_DESCRIPTOR_UI
135398737 PUBCHEM_CID
38 IUPHAR_LIGAND_ID
2612 INN_ID
J60AR2IKIC UNII
11496 MMSL
420 MMSL
4484 MMSL
50904 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
96221003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 27 sections