clozapine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 4010.64 15.62 2007 77525 65930 50459662
Neutropenia 3158.73 15.62 2269 77263 145696 50379896
Granulocytopenia 2966.51 15.62 820 78712 4411 50521181
Neutrophil count increased 2705.76 15.62 967 78565 13228 50512364
Neutrophilia 2365.64 15.62 633 78899 2942 50522650
White blood cell count increased 2298.70 15.62 1183 78349 41057 50484535
Death 2028.21 15.62 2515 77017 322864 50202728
Antipsychotic drug level increased 1645.91 15.62 462 79070 2647 50522945
Salivary hypersecretion 1065.46 15.62 398 79134 6193 50519399
Psychotic disorder 995.74 15.62 544 78988 21268 50504324
White blood cell count decreased 904.06 15.62 1012 78520 115710 50409882
Neutrophil count decreased 898.22 15.62 671 78861 45355 50480237
Sedation 856.91 15.62 557 78975 30053 50495539
Differential white blood cell count abnormal 852.63 15.62 202 79330 497 50525095
Agranulocytosis 811.84 15.62 473 79059 20948 50504644
Mental impairment 797.63 15.62 386 79146 11658 50513934
Leukopenia 612.49 15.62 637 78895 66891 50458701
Myocarditis 569.68 15.62 269 79263 7678 50517914
Anosognosia 556.11 15.62 186 79346 2048 50523544
Pain 550.68 15.62 120 79412 578783 49946809
Platelet count increased 540.07 15.62 317 79215 14223 50511369
Blood prolactin abnormal 505.56 15.62 172 79360 2003 50523589
Schizophrenia 498.54 15.62 240 79292 7157 50518435
Dystonia 496.28 15.62 280 79252 11646 50513946
Disturbance in social behaviour 490.50 15.62 181 79351 2713 50522879
Arthralgia 473.44 15.62 65 79467 438637 50086955
Sexual dysfunction 446.56 15.62 175 79357 3117 50522475
Treatment noncompliance 438.47 15.62 370 79162 29780 50495812
Dyskinesia 436.53 15.62 357 79175 27504 50498088
Rash 431.37 15.62 83 79449 437388 50088204
Metabolic disorder 425.76 15.62 194 79338 5092 50520500
Fatigue 417.95 15.62 304 79228 707297 49818295
Drug level increased 404.99 15.62 294 79238 18974 50506618
Headache 400.05 15.62 149 79383 506386 50019206
Nausea 394.95 15.62 320 79212 705078 49820514
Hallucination, auditory 388.16 15.62 230 79302 10498 50515094
Neuroleptic malignant syndrome 388.09 15.62 233 79299 10897 50514695
Mental disorder 385.48 15.62 301 79231 21690 50503902
Antipsychotic drug level above therapeutic 380.75 15.62 114 79418 845 50524747
Suicide attempt 376.66 15.62 435 79097 51297 50474295
Electrocardiogram QT prolonged 368.91 15.62 431 79101 51455 50474137
Delusion 360.10 15.62 218 79314 10351 50515241
Personality change 343.99 15.62 171 79361 5474 50520118
Pruritus 335.80 15.62 30 79502 283538 50242054
Tachycardia 335.32 15.62 579 78953 99184 50426408
Schizoaffective disorder 326.69 15.62 125 79407 2081 50523511
Alopecia 306.81 15.62 20 79512 245027 50280565
Haemoglobin decreased 297.64 15.62 633 78899 126583 50399009
Rheumatoid arthritis 297.45 15.62 4 79528 202546 50323046
Catatonia 294.22 15.62 135 79397 3601 50521991
Leukocytosis 287.64 15.62 257 79275 22322 50503270
Diarrhoea 282.84 15.62 306 79226 588170 49937422
Joint swelling 277.15 15.62 31 79501 245255 50280337
Drug hypersensitivity 270.73 15.62 37 79495 250973 50274619
Antipsychotic drug level decreased 251.40 15.62 60 79472 154 50525438
Abdominal discomfort 245.43 15.62 36 79496 231605 50293987
Psychiatric decompensation 244.26 15.62 87 79445 1171 50524421
Swelling 241.07 15.62 20 79512 200852 50324740
Pain in extremity 236.44 15.62 68 79464 272797 50252795
Peripheral swelling 235.20 15.62 25 79507 205911 50319681
C-reactive protein increased 231.35 15.62 392 79140 66082 50459510
Sinusitis 216.12 15.62 13 79519 170545 50355047
Drug interaction 215.09 15.62 746 78786 198875 50326717
Overdose 214.63 15.62 480 79052 99247 50426345
Drug intolerance 208.34 15.62 45 79487 219059 50306533
Pre-existing disease 206.65 15.62 49 79483 121 50525471
Sinus tachycardia 205.18 15.62 208 79324 21146 50504446
Eosinophil count decreased 202.08 15.62 81 79451 1534 50524058
Hypersensitivity 196.97 15.62 48 79484 215113 50310479
Arthropathy 194.26 15.62 14 79518 157892 50367700
Troponin increased 184.62 15.62 130 79402 7988 50517604
Somnolence 184.37 15.62 599 78933 154386 50371206
Systemic lupus erythematosus 171.45 15.62 13 79519 140609 50384983
Antipsychotic drug level below therapeutic 170.88 15.62 47 79485 246 50525346
Back pain 169.34 15.62 67 79465 219963 50305629
Dyspnoea 164.14 15.62 389 79143 547219 49978373
Lung neoplasm malignant 162.02 15.62 158 79374 15326 50510266
Urticaria 160.75 15.62 11 79521 129550 50396042
Paranoia 160.74 15.62 132 79400 10216 50515376
Injection site pain 159.48 15.62 3 79529 111021 50414571
Eosinophil count increased 157.15 15.62 122 79410 8708 50516884
Nasopharyngitis 153.01 15.62 56 79476 192871 50332721
Chronic obstructive pulmonary disease 152.41 15.62 289 79243 53146 50472446
Agitation 151.36 15.62 288 79244 53096 50472496
Living in residential institution 149.24 15.62 47 79485 420 50525172
Therapeutic product effect decreased 144.32 15.62 21 79511 136029 50389563
Mean cell haemoglobin decreased 140.86 15.62 79 79453 3244 50522348
Drug ineffective 139.67 15.62 740 78792 818593 49706999
Extrapyramidal disorder 138.17 15.62 128 79404 11642 50513950
Aggression 137.77 15.62 168 79364 20948 50504644
Erythema 137.22 15.62 31 79501 146383 50379209
Stomatitis 137.12 15.62 5 79527 101339 50424253
Neoplasm malignant 136.15 15.62 177 79355 23538 50502054
Treatment failure 129.26 15.62 29 79503 137608 50387984
Monocyte count increased 128.98 15.62 90 79442 5449 50520143
Blood glucose increased 128.04 15.62 320 79212 71004 50454588
Lymphocyte count increased 124.49 15.62 70 79462 2889 50522703
Aspiration 121.03 15.62 107 79425 9157 50516435
General physical condition abnormal 120.26 15.62 73 79459 3480 50522112
Abdominal pain upper 120.08 15.62 50 79482 159259 50366333
Akathisia 119.57 15.62 101 79431 8128 50517464
Eosinophilia 119.42 15.62 147 79385 18505 50507087
Abnormal behaviour 117.99 15.62 150 79382 19508 50506084
Discomfort 116.64 15.62 16 79516 108364 50417228
Mean cell volume decreased 115.53 15.62 64 79468 2565 50523027
Wound 115.33 15.62 15 79517 105779 50419813
Lymphocyte count decreased 114.65 15.62 172 79360 26135 50499457
Coronavirus infection 114.38 15.62 66 79466 2863 50522729
Hypoaesthesia 113.27 15.62 30 79502 127227 50398365
Pleurothotonus 111.90 15.62 50 79482 1251 50524341
Intestinal obstruction 111.43 15.62 170 79362 26213 50499379
Refusal of examination 111.19 15.62 26 79506 59 50525533
On and off phenomenon 111.10 15.62 51 79481 1361 50524231
Neuropathy peripheral 109.72 15.62 12 79520 96745 50428847
Blister 109.70 15.62 6 79526 85412 50440180
Psychotic symptom 108.81 15.62 48 79484 1164 50524428
Electroencephalogram abnormal 108.54 15.62 68 79464 3431 50522161
Drooling 108.09 15.62 67 79465 3317 50522275
Delirium 106.95 15.62 205 79327 37987 50487605
Cough 106.17 15.62 134 79398 241130 50284462
Haemoglobin increased 105.43 15.62 64 79468 3051 50522541
Pneumonia aspiration 105.36 15.62 181 79351 30823 50494769
Choking 104.78 15.62 95 79437 8403 50517189
Muscle rigidity 104.14 15.62 101 79431 9728 50515864
Hyperprolactinaemia 103.39 15.62 65 79467 3300 50522292
Asthenia 103.18 15.62 217 79315 318825 50206767
Neutrophil count abnormal 102.98 15.62 58 79474 2401 50523191
Obsessive-compulsive disorder 101.32 15.62 64 79468 3276 50522316
Terminal state 100.00 15.62 54 79478 2056 50523536
Urinary incontinence 98.92 15.62 167 79365 28041 50497551
Disease progression 98.90 15.62 16 79516 95850 50429742
Mean cell haemoglobin concentration decreased 97.44 15.62 59 79473 2800 50522792
Breast cancer 97.31 15.62 211 79321 42679 50482913
Orthostatic hypotension 96.12 15.62 169 79363 29312 50496280
Impaired healing 95.95 15.62 3 79529 69783 50455809
Blood prolactin increased 95.56 15.62 60 79472 3039 50522553
Generalised tonic-clonic seizure 95.24 15.62 158 79374 26152 50499440
Faecaloma 94.66 15.62 83 79449 7025 50518567
Paraesthesia 93.43 15.62 36 79496 120207 50405385
Lower respiratory tract infection 89.76 15.62 341 79191 94860 50430732
Hallucination 89.73 15.62 215 79317 46442 50479150
Off label use 89.33 15.62 413 79119 474013 50051579
Blood creatine phosphokinase increased 88.37 15.62 153 79379 26214 50499378
Hepatic enzyme increased 87.24 15.62 54 79478 137326 50388266
Diabetes mellitus 85.88 15.62 218 79314 48815 50476777
Metabolic syndrome 85.61 15.62 42 79490 1305 50524287
Psychiatric symptom 85.38 15.62 65 79467 4505 50521087
Insurance issue 85.34 15.62 52 79480 2496 50523096
Myalgia 84.45 15.62 45 79487 124274 50401318
Musculoskeletal pain 84.29 15.62 8 79524 72169 50453423
Intentional self-injury 83.93 15.62 139 79393 22973 50502619
Malignant neoplasm progression 83.84 15.62 6 79526 68118 50457474
Contraindicated product administered 82.21 15.62 68 79464 148890 50376702
Dementia 82.02 15.62 113 79419 15884 50509708
Muscle spasms 81.61 15.62 48 79484 125505 50400087
Acute psychosis 81.34 15.62 48 79484 2172 50523420
Migraine 81.25 15.62 11 79521 75269 50450323
Suicidal ideation 80.66 15.62 230 79302 55155 50470437
Circulatory collapse 80.43 15.62 126 79406 19874 50505718
Haematocrit decreased 80.41 15.62 173 79359 34803 50490789
Troponin T increased 80.08 15.62 36 79496 914 50524678
Febrile neutropenia 77.95 15.62 28 79504 97639 50427953
COVID-19 77.13 15.62 203 79329 46459 50479133
Myoclonus 76.88 15.62 104 79428 14366 50511226
Flushing 76.76 15.62 8 79524 67007 50458585
Arthritis 76.10 15.62 21 79511 86700 50438892
Stoma site discharge 75.83 15.62 38 79494 1237 50524355
Contusion 75.62 15.62 41 79491 112142 50413450
Sopor 75.49 15.62 122 79410 19757 50505835
Pneumonia 75.47 15.62 917 78615 377484 50148108
Lung cancer metastatic 74.73 15.62 46 79486 2249 50523343
Psoriasis 74.67 15.62 10 79522 68990 50456602
Tardive dyskinesia 73.76 15.62 73 79459 7206 50518386
Decreased appetite 73.32 15.62 127 79405 200796 50324796
Pericardial effusion 72.43 15.62 138 79394 25451 50500141
Wrong patient received product 70.93 15.62 40 79492 1660 50523932
Electrocardiogram abnormal 69.27 15.62 72 79460 7533 50518059
Enuresis 67.61 15.62 42 79490 2087 50523505
Epistaxis 67.49 15.62 10 79522 63944 50461648
Parkinsonism 65.33 15.62 75 79457 8772 50516820
Oedema peripheral 65.08 15.62 92 79440 157869 50367723
Constipation 64.58 15.62 506 79026 185202 50340390
Mutism 64.49 15.62 35 79497 1346 50524246
Nasal congestion 64.38 15.62 4 79528 51116 50474476
Red blood cell count decreased 64.06 15.62 155 79377 33680 50491912
Mean cell volume increased 63.90 15.62 46 79486 2926 50522666
Malaise 63.77 15.62 806 78726 334726 50190866
Ileus paralytic 63.60 15.62 52 79480 3998 50521594
Gastrointestinal hypomotility 61.75 15.62 30 79502 912 50524680
Intentional product use issue 61.46 15.62 22 79510 76896 50448696
Refusal of treatment by patient 61.34 15.62 56 79476 4997 50520595
Posture abnormal 60.81 15.62 39 79493 2050 50523542
Herpes zoster 60.52 15.62 18 79514 70768 50454824
Platelet count decreased 60.20 15.62 315 79217 100411 50425181
Rash pruritic 59.49 15.62 4 79528 47842 50477750
Monocyte count decreased 59.37 15.62 37 79495 1849 50523743
Fibromyalgia 58.24 15.62 3 79529 44975 50480617
Electrocardiogram T wave abnormal 58.12 15.62 39 79493 2214 50523378
Anaphylactic reaction 58.09 15.62 8 79524 54047 50471545
Chest discomfort 58.08 15.62 37 79495 92685 50432907
Stoma site irritation 56.94 15.62 18 79514 163 50525429
Impaired self-care 56.77 15.62 35 79497 1716 50523876
Irritable bowel syndrome 56.75 15.62 7 79525 51434 50474158
Wrong product administered 56.63 15.62 55 79477 5305 50520287
Bradykinesia 56.47 15.62 48 79484 3895 50521697
Osteoarthritis 55.89 15.62 19 79513 68587 50457005
Maternal exposure during pregnancy 55.57 15.62 104 79428 159674 50365918
Haematocrit increased 55.36 15.62 36 79496 1938 50523654
Oculogyric crisis 55.10 15.62 32 79500 1405 50524187
Acute kidney injury 54.65 15.62 180 79352 227878 50297714
Sudden death 54.57 15.62 69 79463 8922 50516670
Blood urea decreased 54.44 15.62 37 79495 2145 50523447
Gastrointestinal carcinoma 54.40 15.62 32 79500 1439 50524153
Stoma site erythema 54.30 15.62 27 79505 864 50524728
Mania 54.30 15.62 76 79456 10840 50514752
Ileus 54.11 15.62 84 79448 13145 50512447
Blood alkaline phosphatase increased 52.84 15.62 154 79378 37372 50488220
Epilepsy 52.25 15.62 109 79423 21458 50504134
Hot flush 51.29 15.62 5 79527 44164 50481428
Gastrointestinal disorder 51.01 15.62 44 79488 94412 50431180
Freezing phenomenon 50.98 15.62 27 79505 988 50524604
Mucosal inflammation 50.97 15.62 3 79529 40139 50485453
Multiple sclerosis relapse 49.53 15.62 5 79527 42959 50482633
Electrocardiogram T wave inversion 49.39 15.62 41 79491 3220 50522372
Benign ethnic neutropenia 49.12 15.62 9 79523 0 50525592
Urinary tract infection 48.57 15.62 552 78980 223468 50302124
Loss of personal independence in daily activities 48.08 15.62 25 79507 70025 50455567
Bronchitis 47.70 15.62 56 79476 104103 50421489
Visual impairment 47.40 15.62 24 79508 68251 50457341
Dry skin 47.35 15.62 6 79526 43185 50482407
Intentional overdose 47.10 15.62 209 79323 62295 50463297
Chills 46.44 15.62 50 79482 96637 50428955
Psychiatric evaluation 45.84 15.62 10 79522 14 50525578
Body temperature increased 45.46 15.62 130 79402 31211 50494381
Toxicity to various agents 45.33 15.62 522 79010 211977 50313615
Musculoskeletal stiffness 45.22 15.62 83 79449 128398 50397194
Overweight 45.08 15.62 38 79494 3048 50522544
Pancreatic fibrosis 44.82 15.62 13 79519 85 50525507
Red cell distribution width increased 44.69 15.62 61 79471 8498 50517094
Hypothermia 44.61 15.62 73 79459 11943 50513649
Hyperkinesia 44.49 15.62 28 79504 1424 50524168
Neck pain 44.45 15.62 17 79515 57050 50468542
Weight decreased 44.27 15.62 188 79344 221057 50304535
Blood pressure increased 44.25 15.62 89 79443 133043 50392549
Dyspnoea exertional 43.84 15.62 13 79519 51220 50474372
Muscle injury 43.62 15.62 4 79528 37107 50488485
Obesity 43.26 15.62 87 79445 16688 50508904
Dyspepsia 43.16 15.62 32 79500 74065 50451527
Hypokalaemia 42.82 15.62 45 79487 87947 50437645
Haematochezia 42.62 15.62 6 79526 39876 50485716
Persecutory delusion 42.51 15.62 33 79499 2354 50523238
Thrombosis 41.27 15.62 18 79514 55815 50469777
Night sweats 41.18 15.62 3 79529 33571 50492021
Negativism 40.96 15.62 17 79515 353 50525239
Loss of consciousness 40.55 15.62 292 79240 104061 50421531
Abdominal pain 40.07 15.62 213 79319 236015 50289577
Oedema 39.99 15.62 31 79501 70150 50455442
Borderline personality disorder 39.44 15.62 20 79512 668 50524924
Foreign body in gastrointestinal tract 39.37 15.62 10 79522 36 50525556
Inappropriate schedule of product administration 39.34 15.62 33 79499 71798 50453794
Osteoporosis 39.12 15.62 11 79521 44868 50480724
Dysgeusia 39.01 15.62 7 79525 38909 50486683
Myocardial fibrosis 39.00 15.62 20 79512 684 50524908
Cervix neoplasm 38.54 15.62 14 79518 200 50525392
Imprisonment 38.48 15.62 14 79518 201 50525391
Pain in jaw 38.33 15.62 7 79525 38421 50487171
Megacolon 38.04 15.62 27 79505 1679 50523913
Interstitial lung disease 37.96 15.62 18 79514 53158 50472434
Red blood cell count increased 37.62 15.62 32 79500 2599 50522993
Central obesity 37.19 15.62 22 79510 1000 50524592
Product use issue 37.15 15.62 116 79416 149359 50376233
Dizziness 36.97 15.62 357 79175 346012 50179580
Suicidal behaviour 36.72 15.62 30 79502 2304 50523288
Vomiting 36.71 15.62 507 79025 460251 50065341
Parkinson's disease 36.50 15.62 23 79509 1172 50524420
Akinesia 36.41 15.62 25 79507 1474 50524118
Skin ulcer 36.17 15.62 6 79526 35312 50490280
Cardiac arrest 35.99 15.62 240 79292 83411 50442181
Cardiac steatosis 35.97 15.62 9 79523 30 50525562
Feeling abnormal 35.91 15.62 91 79441 125401 50400191
Cardiomyopathy 35.70 15.62 77 79455 15509 50510083
Electroconvulsive therapy 35.64 15.62 10 79522 57 50525535
Medication error 35.38 15.62 131 79401 35973 50489619
Fibroma 35.36 15.62 19 79513 716 50524876
Dysarthria 35.23 15.62 134 79398 37269 50488323
Metastatic neoplasm 35.02 15.62 36 79496 3718 50521874
Seizure 34.96 15.62 310 79222 117564 50408028
Sinus rhythm 34.93 15.62 18 79514 622 50524970
Depressed level of consciousness 34.91 15.62 168 79364 51785 50473807
Schizoaffective disorder bipolar type 34.28 15.62 11 79521 105 50525487
Rebound psychosis 34.26 15.62 8 79524 18 50525574
Device expulsion 34.17 15.62 3 79529 28819 50496773
Insomnia 34.10 15.62 150 79382 174715 50350877
Social avoidant behaviour 33.95 15.62 31 79501 2766 50522826
Cataract 33.78 15.62 16 79516 47284 50478308
Muscular weakness 33.76 15.62 61 79471 94952 50430640
Ovarian cancer 33.63 15.62 41 79491 5108 50520484
Hepatitis C 33.50 15.62 40 79492 4877 50520715
Fluid retention 33.41 15.62 19 79513 50630 50474962
Wheezing 33.38 15.62 29 79503 62018 50463574
Rhinorrhoea 33.10 15.62 20 79512 51563 50474029
Burning sensation 33.04 15.62 15 79517 45431 50480161
Ankle fracture 33.00 15.62 75 79457 15647 50509945
Plasma cell myeloma 32.80 15.62 5 79527 31317 50494275
Hypertension 32.79 15.62 196 79336 211007 50314585
Parkinsonism hyperpyrexia syndrome 32.56 15.62 11 79521 125 50525467
Intestinal strangulation 32.19 15.62 10 79522 85 50525507
Granulocytosis 31.97 15.62 9 79523 52 50525540
International normalised ratio increased 31.75 15.62 14 79518 43138 50482454
Angioedema 31.44 15.62 10 79522 37666 50487926
Hallucination, visual 31.42 15.62 76 79456 16506 50509086
Stoma site pain 31.10 15.62 18 79514 785 50524807
Eye pain 31.07 15.62 4 79528 28445 50497147
Bundle branch block right 30.36 15.62 37 79495 4608 50520984
Monocytosis 30.06 15.62 13 79519 300 50525292
Serositis 29.95 15.62 16 79516 596 50524996
Waxy flexibility 29.73 15.62 10 79522 112 50525480
Abnormal clotting factor 29.73 15.62 10 79522 112 50525480
Atrial fibrillation 29.71 15.62 73 79459 101672 50423920
Intestinal pseudo-obstruction 29.47 15.62 17 79515 737 50524855
Pseudophaeochromocytoma 29.35 15.62 9 79523 73 50525519
Gastrooesophageal reflux disease 29.05 15.62 47 79485 76381 50449211
Oral pain 28.63 15.62 3 79529 25030 50500562
Drug monitoring procedure incorrectly performed 28.60 15.62 10 79522 127 50525465
Polyserositis 28.53 15.62 12 79520 258 50525334
Confusional state 28.45 15.62 430 79102 185498 50340094
Influenza B virus test positive 28.45 15.62 12 79520 260 50525332
Myocardial infarction 28.41 15.62 238 79294 88789 50436803
Tobacco interaction 28.29 15.62 7 79525 22 50525570
Gamma-glutamyltransferase increased 27.79 15.62 106 79426 29517 50496075
Dry eye 27.72 15.62 8 79524 32087 50493505
Therapy cessation 27.72 15.62 97 79435 25914 50499678
Hyperkalaemia 27.70 15.62 21 79511 48068 50477524
Parotitis 27.52 15.62 20 79512 1291 50524301
Neutrophil count normal 27.29 15.62 5 79527 0 50525592
Body mass index increased 27.04 15.62 18 79514 1008 50524584
Toxicologic test abnormal 26.92 15.62 15 79517 608 50524984
Hepatic steatosis 26.91 15.62 92 79440 24292 50501300
Visceral congestion 26.86 15.62 12 79520 300 50525292
Productive cough 26.71 15.62 26 79506 52668 50472924
Hypocalcaemia 26.50 15.62 5 79527 26811 50498781
Arteriosclerosis coronary artery 26.48 15.62 45 79487 7591 50518001
Basal cell carcinoma 26.20 15.62 3 79529 23353 50502239
Rash erythematous 26.13 15.62 11 79521 34841 50490751
Product quality issue 26.09 15.62 8 79524 30850 50494742
Microcytosis 26.05 15.62 10 79522 168 50525424
Eosinopenia 25.88 15.62 7 79525 34 50525558
Self-injurious ideation 25.69 15.62 24 79508 2205 50523387
Diverticulitis 25.65 15.62 10 79522 33172 50492420
Intestinal dilatation 25.50 15.62 20 79512 1448 50524144
Swelling face 25.47 15.62 27 79505 52568 50473024
Blood albumin decreased 25.44 15.62 61 79471 13175 50512417
Echocardiogram abnormal 25.25 15.62 18 79514 1127 50524465
Bipolar disorder 25.01 15.62 41 79491 6716 50518876
Osteonecrosis 24.99 15.62 3 79529 22514 50503078
Cystitis 24.99 15.62 20 79512 44544 50481048
Swollen tongue 24.98 15.62 7 79525 28623 50496969
Coma 24.95 15.62 164 79368 56715 50468877
Globulin abnormal 24.94 15.62 5 79527 3 50525589
Eye movement disorder 24.65 15.62 33 79499 4512 50521080
Grandiosity 24.59 15.62 11 79521 276 50525316
Chemotherapy 24.54 15.62 19 79513 1350 50524242
Parotid gland enlargement 24.24 15.62 15 79517 740 50524852
Rash maculo-papular 24.22 15.62 6 79526 26635 50498957
Affective disorder 24.19 15.62 35 79497 5146 50520446
Neuralgia 24.05 15.62 3 79529 21860 50503732
Stevens-Johnson syndrome 23.89 15.62 3 79529 21749 50503843
Neoplasm progression 23.87 15.62 8 79524 29149 50496443
Dysphonia 23.69 15.62 16 79516 38876 50486716
Upper respiratory tract infection 23.68 15.62 42 79490 65856 50459736
Impulsive behaviour 23.48 15.62 19 79513 1439 50524153
Sciatica 23.36 15.62 3 79529 21379 50504213
Vision blurred 23.30 15.62 56 79476 78591 50447001
Wrong technique in product usage process 23.17 15.62 32 79500 55478 50470114
Subileus 23.14 15.62 25 79507 2734 50522858
Dysphemia 23.13 15.62 23 79509 2283 50523309
Cervix cancer metastatic 23.13 15.62 6 79526 24 50525568
Hepatotoxicity 23.12 15.62 7 79525 27219 50498373
Suspiciousness 23.06 15.62 11 79521 321 50525271
Skin exfoliation 23.05 15.62 12 79520 33600 50491992
Basophil count increased 22.91 15.62 15 79517 817 50524775
Nephrolithiasis 22.90 15.62 13 79519 34680 50490912
Liver function test increased 22.83 15.62 6 79526 25600 50499992
Haemoptysis 22.79 15.62 6 79526 25567 50500025
Blood triglycerides increased 22.68 15.62 53 79479 11259 50514333
Stupor 22.54 15.62 28 79504 3555 50522037
Vertigo 22.53 15.62 29 79503 51803 50473789
Psychomotor hyperactivity 22.52 15.62 47 79485 9254 50516338
Palliative care 22.33 15.62 11 79521 345 50525247
Ill-defined disorder 22.32 15.62 32 79500 54622 50470970
Bradycardia 22.32 15.62 42 79490 64384 50461208
Haematoma 22.28 15.62 10 79522 30500 50495092
Echolalia 22.28 15.62 9 79523 174 50525418
Thrombocytosis 22.24 15.62 33 79499 4963 50520629
Activated partial thromboplastin time abnormal 22.17 15.62 8 79524 112 50525480
Unresponsive to stimuli 22.04 15.62 101 79431 30508 50495084
Skin discolouration 22.02 15.62 12 79520 32745 50492847
Intervertebral disc protrusion 21.95 15.62 3 79529 20390 50505202
Gastrointestinal haemorrhage 21.88 15.62 52 79480 73269 50452323
Catecholamines urine increased 21.83 15.62 4 79528 0 50525592
Laryngeal cancer stage III 21.81 15.62 5 79527 10 50525582
Body mass index decreased 21.65 15.62 11 79521 369 50525223
Miosis 21.64 15.62 37 79495 6273 50519319
Neutrophil percentage increased 21.63 15.62 24 79508 2703 50522889
Fungal infection 21.61 15.62 10 79522 29955 50495637
Eye swelling 21.60 15.62 3 79529 20141 50505451
Dementia with Lewy bodies 21.41 15.62 10 79522 278 50525314
Incontinence 21.36 15.62 48 79484 9937 50515655
Personality disorder 21.35 15.62 30 79502 4294 50521298
Neutrophil toxic granulation present 21.27 15.62 6 79526 35 50525557
Stoma site reaction 20.92 15.62 9 79523 205 50525387
Hypervolaemia 20.87 15.62 7 79525 25492 50500100
Liver function test abnormal 20.77 15.62 130 79402 44209 50481383
Cardiac failure congestive 20.59 15.62 66 79466 84316 50441276
Poverty of speech 20.37 15.62 10 79522 311 50525281
Dehydration 20.35 15.62 148 79384 152301 50373291
Nervousness 20.29 15.62 9 79523 27642 50497950
Metamyelocyte count increased 20.26 15.62 9 79523 222 50525370
Poor personal hygiene 20.26 15.62 10 79522 315 50525277
Blood bicarbonate increased 20.17 15.62 13 79519 689 50524903
Cardiac disorder 20.13 15.62 126 79406 42853 50482739
Lip swelling 19.88 15.62 7 79525 24729 50500863
Brain neoplasm 19.86 15.62 27 79505 3746 50521846
Palpitations 19.68 15.62 79 79453 94427 50431165
Personality change due to a general medical condition 19.66 15.62 7 79525 94 50525498
Persistent depressive disorder 19.63 15.62 14 79518 877 50524715
Suspected COVID-19 19.33 15.62 17 79515 1444 50524148
Product dispensing error 19.31 15.62 43 79489 8848 50516744
Nuchal rigidity 19.30 15.62 12 79520 597 50524995
Apathy 19.28 15.62 39 79493 7509 50518083
Hip arthroplasty 19.24 15.62 12 79520 30417 50495175
Joint stiffness 19.10 15.62 12 79520 30296 50495296
Drug level above therapeutic 19.06 15.62 27 79505 3893 50521699
Bladder trabeculation 19.01 15.62 6 79526 54 50525538
Polydipsia 19.00 15.62 24 79508 3100 50522492
C-reactive protein abnormal 18.96 15.62 10 79522 27799 50497793
Incoherent 18.91 15.62 28 79504 4202 50521390
Sexually inappropriate behaviour 18.84 15.62 7 79525 107 50525485
Left ventricular hypertrophy 18.75 15.62 30 79502 4815 50520777
Laparotomy 18.64 15.62 8 79524 181 50525411
Galactorrhoea 18.63 15.62 26 79506 3697 50521895
Vascular encephalopathy 18.53 15.62 10 79522 380 50525212
Heart rate decreased 18.51 15.62 18 79514 36479 50489113
Eczema eyelids 18.43 15.62 7 79525 114 50525478
Femur fracture 18.40 15.62 19 79513 37445 50488147
Alcohol poisoning 18.14 15.62 18 79514 1782 50523810
Ear pain 18.10 15.62 11 79521 28272 50497320
Asterixis 18.09 15.62 15 79517 1176 50524416
Cerebral haemorrhage 18.05 15.62 10 79522 27042 50498550
Illness anxiety disorder 17.89 15.62 7 79525 124 50525468
Lethargy 17.86 15.62 136 79396 49296 50476296
Hyponatraemia 17.81 15.62 84 79448 96055 50429537
Haematuria 17.78 15.62 9 79523 25604 50499988
Localised infection 17.62 15.62 9 79523 25476 50500116
Condition aggravated 17.60 15.62 345 79187 296713 50228879
Therapeutic product effect incomplete 17.52 15.62 79 79453 91436 50434156
Wrong drug 17.44 15.62 7 79525 133 50525459
Psychotic behaviour 17.43 15.62 11 79521 562 50525030
Rectal haemorrhage 17.35 15.62 21 79511 38537 50487055
Gallbladder cholesterolosis 17.29 15.62 12 79520 720 50524872
Accidental exposure to product 17.28 15.62 77 79455 22980 50502612
Hallucination, olfactory 17.21 15.62 8 79524 220 50525372
Blunted affect 17.21 15.62 8 79524 220 50525372
Hypochromasia 17.20 15.62 9 79523 321 50525271
Osteopenia 17.19 15.62 3 79529 17015 50508577
Nodule 17.17 15.62 3 79529 17000 50508592
Physical assault 17.15 15.62 13 79519 895 50524697
Musculoskeletal chest pain 17.13 15.62 4 79528 18482 50507110
Therapeutic product effect variable 17.13 15.62 14 79518 1076 50524516
Colitis ulcerative 16.96 15.62 3 79529 16851 50508741
Lymphocyte percentage increased 16.95 15.62 9 79523 331 50525261
Obsessive-compulsive symptom 16.94 15.62 5 79527 35 50525557
Gastric disorder 16.89 15.62 13 79519 29535 50496057
Electrocardiogram T wave amplitude decreased 16.80 15.62 9 79523 337 50525255
Flatulence 16.79 15.62 13 79519 29445 50496147
Foreign body 16.77 15.62 18 79514 1953 50523639
Mental status changes 16.77 15.62 106 79426 36166 50489426
Acne 16.71 15.62 5 79527 19590 50506002
Appendicitis perforated 16.68 15.62 16 79516 1520 50524072
Appendicitis 16.66 15.62 34 79498 6590 50519002
Left ventricular dysfunction 16.63 15.62 45 79487 10461 50515131
Quarantine 16.59 15.62 5 79527 38 50525554
Device related infection 16.44 15.62 6 79526 20729 50504863
Melaena 16.43 15.62 11 79521 26853 50498739
Myelocyte present 16.37 15.62 3 79529 0 50525592
Phobic avoidance 16.37 15.62 3 79529 0 50525592
Foreign body ingestion 16.37 15.62 3 79529 0 50525592
Eosinophilic myocarditis 16.35 15.62 9 79523 356 50525236
Live birth 16.34 15.62 3 79529 16405 50509187
Lung carcinoma cell type unspecified stage III 16.31 15.62 6 79526 89 50525503
Blood pressure systolic increased 16.28 15.62 19 79513 35430 50490162
Skin lesion 16.27 15.62 11 79521 26716 50498876
Thinking abnormal 16.18 15.62 42 79490 9525 50516067
Influenza 16.14 15.62 79 79453 89459 50436133
Depressed mood 16.09 15.62 100 79432 33923 50491669
Cholestasis 16.08 15.62 10 79522 25391 50500201
Ataxia 16.08 15.62 53 79479 13733 50511859
Neglect of personal appearance 16.07 15.62 6 79526 93 50525499
Cardiopulmonary failure 16.06 15.62 23 79509 3350 50522242
Hypoglycaemia 15.99 15.62 38 79494 53543 50472049
Anxiety disorder 15.97 15.62 24 79508 3649 50521943
Faeces discoloured 15.94 15.62 3 79529 16121 50509471
Restlessness 15.91 15.62 80 79452 25093 50500499
White blood cell disorder 15.89 15.62 18 79514 2074 50523518
Pulmonary valve incompetence 15.82 15.62 14 79518 1199 50524393
Thought blocking 15.78 15.62 6 79526 98 50525494
Ischaemic stroke 15.70 15.62 3 79529 15945 50509647
Heart rate increased 15.65 15.62 188 79344 77062 50448530

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 5756.94 14.80 3147 125597 42841 29402942
Neutrophil count increased 4434.96 14.80 1847 126897 12895 29432888
White blood cell count increased 3761.00 14.80 2223 126521 35293 29410490
Neutropenia 3710.97 14.80 3647 125097 128064 29317719
Granulocytopenia 3437.07 14.80 1203 127541 4791 29440992
Neutrophilia 3037.68 14.80 971 127773 2695 29443088
Differential white blood cell count abnormal 2494.46 14.80 658 128086 611 29445172
Death 1866.45 14.80 4379 124365 337705 29108078
Antipsychotic drug level increased 1824.28 14.80 642 128102 2601 29443182
Myocarditis 1715.28 14.80 873 127871 10083 29435700
Psychotic disorder 1525.14 14.80 1004 127740 19350 29426433
Mental impairment 1429.65 14.80 728 128016 8413 29437370
Salivary hypersecretion 1369.11 14.80 661 128083 6748 29439035
Neutrophil count decreased 1335.37 14.80 1268 127476 42299 29403484
Agranulocytosis 1329.54 14.80 922 127822 19418 29426365
White blood cell count decreased 1245.71 14.80 1668 127076 81694 29364089
Neuroleptic malignant syndrome 880.78 14.80 656 128088 15492 29430291
Sedation 871.85 14.80 672 128072 16733 29429050
Tachycardia 797.61 14.80 1255 127489 71155 29374628
Schizophrenia 764.99 14.80 430 128314 6135 29439648
Leukopenia 648.44 14.80 986 127758 54217 29391566
Platelet count increased 624.96 14.80 414 128330 8049 29437734
Treatment noncompliance 620.55 14.80 640 128104 23587 29422196
Antipsychotic drug level decreased 605.45 14.80 202 128542 667 29445116
Eosinophil count increased 569.74 14.80 371 128373 6998 29438785
Hallucination, auditory 543.81 14.80 399 128345 9194 29436589
Troponin increased 541.11 14.80 391 128353 8792 29436991
Mental disorder 534.79 14.80 446 128298 12459 29433324
Lower respiratory tract infection 510.53 14.80 603 128141 25899 29419884
Antipsychotic drug level below therapeutic 489.21 14.80 216 128528 1758 29444025
Rash 454.09 14.80 132 128612 189687 29256096
C-reactive protein increased 450.94 14.80 741 128003 43522 29402261
Acute kidney injury 430.71 14.80 317 128427 264950 29180833
Arthralgia 424.25 14.80 54 128690 139563 29306220
Diarrhoea 418.99 14.80 501 128243 332197 29113586
Antipsychotic drug level above therapeutic 413.20 14.80 162 128582 939 29444844
Fatigue 405.38 14.80 471 128273 316350 29129433
Nausea 397.64 14.80 405 128339 288850 29156933
Pruritus 394.64 14.80 30 128714 116819 29328964
Catatonia 372.68 14.80 236 128508 4232 29441551
Leukocytosis 369.51 14.80 458 128286 20684 29425099
Delusion 361.24 14.80 336 128408 10880 29434903
Pain 357.00 14.80 150 128594 171282 29274501
Blood creatine phosphokinase increased 355.47 14.80 636 128108 40008 29405775
Monocyte count increased 328.47 14.80 207 128537 3679 29442104
Eosinophil count decreased 326.74 14.80 138 128606 995 29444788
Febrile neutropenia 314.20 14.80 55 128689 112185 29333598
Sinus tachycardia 310.37 14.80 355 128389 14714 29431069
Headache 308.76 14.80 188 128556 173819 29271964
Malignant neoplasm progression 292.02 14.80 6 128738 73853 29371930
Faecaloma 292.01 14.80 198 128546 4004 29441779
Off label use 284.61 14.80 550 128194 300250 29145533
Asthenia 277.96 14.80 317 128427 214933 29230850
Pain in extremity 276.52 14.80 70 128674 110363 29335420
Obsessive-compulsive disorder 274.46 14.80 197 128547 4379 29441404
Dyspnoea 273.64 14.80 640 128104 326092 29119691
Malaise 266.41 14.80 1384 127360 158218 29287565
Neuropathy peripheral 252.21 14.80 14 128730 71013 29374770
Psychiatric decompensation 247.32 14.80 124 128620 1380 29444403
Haemoglobin decreased 240.97 14.80 1022 127722 107353 29338430
Decreased appetite 231.04 14.80 177 128567 145165 29300618
Lung neoplasm malignant 227.05 14.80 296 128448 14061 29431722
Paranoia 226.23 14.80 246 128498 9631 29436152
Hyperkalaemia 224.65 14.80 10 128734 61382 29384401
Atrial fibrillation 220.38 14.80 92 128652 105554 29340229
Pneumonia aspiration 219.01 14.80 490 128254 36247 29409536
Disease progression 218.83 14.80 45 128699 81871 29363912
Erythema 213.80 14.80 36 128708 75570 29370213
Peripheral swelling 210.50 14.80 18 128726 63721 29382062
Cardiomyopathy 209.58 14.80 289 128455 14498 29431285
Lymphocyte count increased 209.41 14.80 138 128606 2656 29443127
Oedema peripheral 205.27 14.80 97 128647 103460 29342323
Back pain 202.44 14.80 96 128648 102188 29343595
Urticaria 199.68 14.80 9 128735 54651 29391132
Aggression 196.31 14.80 460 128284 35081 29410702
Living in residential institution 194.65 14.80 66 128678 232 29445551
Abnormal behaviour 194.56 14.80 356 128388 22771 29423012
Pre-existing disease 193.92 14.80 51 128693 46 29445737
Mean cell volume decreased 192.80 14.80 97 128647 1088 29444695
Drooling 190.27 14.80 134 128610 2887 29442896
Imprisonment 183.53 14.80 72 128672 418 29445365
Electrocardiogram QT prolonged 180.60 14.80 450 128294 35687 29410096
Drug level increased 179.75 14.80 306 128438 18481 29427302
Akathisia 179.54 14.80 182 128562 6560 29439223
Joint swelling 178.61 14.80 9 128735 49621 29396162
Mean cell haemoglobin decreased 177.34 14.80 96 128648 1265 29444518
Neoplasm malignant 177.11 14.80 287 128457 16638 29429145
Anosognosia 175.66 14.80 81 128663 737 29445046
Psychotic symptom 173.90 14.80 96 128648 1318 29444465
Eosinophilia 170.08 14.80 328 128416 21833 29423950
Drug hypersensitivity 168.00 14.80 45 128699 68361 29377422
Interstitial lung disease 166.48 14.80 26 128718 57692 29388091
Gastrointestinal hypomotility 162.83 14.80 79 128665 814 29444969
Dyskinesia 162.70 14.80 304 128440 19757 29426026
Epistaxis 161.78 14.80 18 128726 51686 29394097
Obesity 158.52 14.80 205 128539 9658 29436125
Muscle rigidity 158.17 14.80 200 128544 9211 29436572
Circulatory collapse 155.24 14.80 286 128458 18387 29427396
General physical condition abnormal 154.21 14.80 121 128623 3089 29442694
Muscle spasms 153.91 14.80 46 128698 65036 29380747
Agitation 152.59 14.80 531 128213 50773 29395010
Persecutory delusion 149.03 14.80 101 128643 2040 29443743
Extrapyramidal disorder 147.97 14.80 208 128536 10623 29435160
Stomatitis 142.86 14.80 4 128740 37109 29408674
Anaemia 141.61 14.80 428 128316 200523 29245260
Hepatitis C 139.77 14.80 183 128561 8727 29437056
Pericarditis 137.59 14.80 180 128564 8577 29437206
International normalised ratio increased 137.43 14.80 16 128728 44356 29401427
Left ventricular dysfunction 136.81 14.80 181 128563 8721 29437062
Schizoaffective disorder 136.67 14.80 75 128669 1017 29444766
Body temperature increased 133.63 14.80 232 128512 14233 29431550
Red blood cell count decreased 133.39 14.80 324 128420 25278 29420505
Benign ethnic neutropenia 132.28 14.80 33 128711 18 29445765
Hypoaesthesia 131.59 14.80 35 128709 53432 29392351
Paraesthesia 131.11 14.80 36 128708 53809 29391974
Platelet count decreased 128.80 14.80 838 127906 103834 29341949
Neutrophil count abnormal 128.77 14.80 81 128663 1434 29444349
Tardive dyskinesia 127.51 14.80 135 128609 5123 29440660
Choking 126.51 14.80 125 128619 4366 29441417
Myalgia 125.51 14.80 84 128660 73935 29371848
Lymphocyte count decreased 124.98 14.80 266 128478 19005 29426778
Aspiration 123.76 14.80 185 128559 9995 29435788
Electrocardiogram abnormal 122.09 14.80 155 128589 7167 29438616
Intestinal obstruction 120.33 14.80 262 128482 19015 29426768
Renal failure 119.56 14.80 208 128536 118391 29327392
Enuresis 118.78 14.80 87 128657 1997 29443786
Left ventricular hypertrophy 118.31 14.80 146 128598 6557 29439226
Injection site pain 116.36 14.80 6 128738 32440 29413343
Plasma cell myeloma 115.90 14.80 13 128731 37102 29408681
Haematochezia 115.37 14.80 13 128731 36970 29408813
Overdose 114.52 14.80 665 128079 79154 29366629
Hypersensitivity 113.61 14.80 44 128700 52859 29392924
Blood prolactin abnormal 112.99 14.80 61 128683 799 29444984
Delirium 112.15 14.80 402 128342 38995 29406788
Troponin T increased 111.11 14.80 72 128672 1345 29444438
Intentional product use issue 110.07 14.80 25 128719 42473 29403310
Dystonia 109.81 14.80 171 128573 9578 29436205
Mucosal inflammation 109.76 14.80 7 128737 31588 29414195
Mean cell volume increased 109.28 14.80 89 128655 2400 29443383
Suicide attempt 109.26 14.80 362 128382 33748 29412035
Ileus paralytic 109.12 14.80 124 128620 5099 29440684
Cardiac failure congestive 108.43 14.80 104 128640 76477 29369306
Cough 108.17 14.80 245 128499 126482 29319301
Haemoglobin increased 107.77 14.80 94 128650 2792 29442991
Chills 106.70 14.80 92 128652 71208 29374575
Therapeutic product effect variable 106.17 14.80 78 128666 1799 29443984
Anaphylactic reaction 106.02 14.80 3 128741 27570 29418213
Heart rate increased 103.83 14.80 389 128355 38549 29407234
COVID-19 103.81 14.80 369 128375 35645 29410138
Refusal of examination 103.78 14.80 24 128720 3 29445780
Hypokalaemia 102.55 14.80 45 128699 50158 29395625
Thrombosis 102.52 14.80 30 128714 43015 29402768
Dizziness 102.52 14.80 451 128293 189233 29256550
Sinusitis 102.45 14.80 14 128730 34336 29411447
Pancytopenia 102.22 14.80 127 128617 83041 29362742
Disinhibition 101.57 14.80 87 128657 2520 29443263
Rheumatoid arthritis 98.55 14.80 12 128732 32140 29413643
Drug ineffective 97.47 14.80 1062 127682 362108 29083675
Myoclonus 97.25 14.80 193 128551 13116 29432667
Seizure 97.05 14.80 716 128028 92407 29353376
Megacolon 96.02 14.80 69 128675 1536 29444247
Body mass index increased 95.54 14.80 54 128690 778 29445005
Bradycardia 95.41 14.80 87 128657 65542 29380241
Hepatitis C virus test positive 94.91 14.80 39 128705 260 29445523
Hypoglycaemia 94.62 14.80 46 128698 48300 29397483
Thinking abnormal 93.95 14.80 115 128629 5121 29440662
Orthostatic hypotension 92.90 14.80 262 128482 22367 29423416
Lactic acidosis 90.98 14.80 12 128732 30235 29415548
Echocardiogram abnormal 90.59 14.80 53 128691 818 29444965
Psychiatric symptom 90.39 14.80 89 128655 3095 29442688
Therapy cessation 89.62 14.80 196 128548 14266 29431517
Ascites 88.17 14.80 25 128719 36594 29409189
Gastrointestinal haemorrhage 88.09 14.80 131 128613 79402 29366381
Haematocrit decreased 86.77 14.80 301 128443 28721 29417062
Musculoskeletal pain 85.87 14.80 12 128732 28941 29416842
Disturbance in social behaviour 85.76 14.80 66 128678 1636 29444147
On and off phenomenon 84.77 14.80 69 128675 1859 29443924
Drug reaction with eosinophilia and systemic symptoms 84.45 14.80 11 128733 27981 29417802
Coma scale abnormal 82.23 14.80 88 128656 3381 29442402
Inappropriate schedule of product administration 81.57 14.80 46 128698 44426 29401357
Generalised tonic-clonic seizure 80.93 14.80 224 128520 18915 29426868
Mean cell haemoglobin concentration decreased 80.78 14.80 53 128691 1012 29444771
Coronavirus infection 80.76 14.80 85 128659 3203 29442580
Cardiac disorder 80.74 14.80 349 128395 36914 29408869
Somnolence 80.68 14.80 691 128053 93264 29352519
Swelling 79.72 14.80 27 128717 35256 29410527
Psoriasis 79.46 14.80 21 128723 32206 29413577
Muscular weakness 79.16 14.80 92 128652 61960 29383823
Apathy 79.12 14.80 115 128629 6056 29439727
Haematuria 79.05 14.80 47 128697 44092 29401691
Blood prolactin increased 78.42 14.80 60 128684 1474 29444309
Freezing phenomenon 77.17 14.80 55 128689 1208 29444575
Terminal state 76.49 14.80 85 128659 3409 29442374
Dysgeusia 75.94 14.80 6 128738 22668 29423115
Dyspnoea exertional 75.64 14.80 32 128712 36458 29409325
Psychiatric evaluation 75.50 14.80 17 128727 0 29445783
Tobacco interaction 75.16 14.80 24 128720 66 29445717
Oedema 74.07 14.80 42 128702 40441 29405342
Renal impairment 72.85 14.80 153 128591 81180 29364603
Weight decreased 70.87 14.80 377 128367 150528 29295255
Social avoidant behaviour 70.38 14.80 75 128669 2867 29442916
Vision blurred 70.24 14.80 44 128700 40132 29405651
Wheezing 69.14 14.80 29 128715 33211 29412572
Stoma site discharge 68.01 14.80 45 128699 872 29444911
Haematoma 67.95 14.80 10 128734 23202 29422581
Herpes zoster 67.89 14.80 23 128721 30029 29415754
Abdominal pain upper 67.00 14.80 101 128643 60892 29384891
Oculogyric crisis 66.88 14.80 52 128692 1309 29444474
Colitis ischaemic 66.78 14.80 103 128641 5720 29440063
Angioedema 66.13 14.80 28 128716 31887 29413896
Congestive cardiomyopathy 66.06 14.80 110 128634 6520 29439263
Pneumonitis 65.94 14.80 20 128724 28024 29417759
Troponin I increased 65.84 14.80 60 128684 1890 29443893
Constipation 65.30 14.80 772 127972 113388 29332395
Rebound psychosis 65.21 14.80 25 128719 135 29445648
Parkinson's disease 64.72 14.80 51 128693 1310 29444473
Sudden death 64.53 14.80 170 128574 13940 29431843
Cerebral haemorrhage 64.43 14.80 28 128716 31398 29414385
Dehydration 64.23 14.80 269 128475 114479 29331304
Arthritis 64.21 14.80 15 128729 25004 29420779
Melaena 63.57 14.80 28 128716 31148 29414635
Haemorrhage 61.71 14.80 63 128681 45009 29400774
Overweight 61.63 14.80 51 128693 1407 29444376
Metabolic disorder 61.25 14.80 78 128666 3617 29442166
Delusional disorder, persecutory type 60.59 14.80 27 128717 225 29445558
Pneumocystis jirovecii pneumonia 60.48 14.80 3 128741 16776 29429007
Rash pruritic 60.26 14.80 12 128732 22351 29423432
Intentional self-injury 59.93 14.80 153 128591 12308 29433475
Parkinsonism 59.88 14.80 111 128633 7167 29438616
Dry skin 59.76 14.80 14 128730 23293 29422490
Arthropathy 59.28 14.80 11 128733 21543 29424240
Influenza like illness 59.12 14.80 237 128507 24233 29421550
Intestinal pseudo-obstruction 58.54 14.80 47 128697 1241 29444542
Acute myocardial infarction 58.40 14.80 75 128669 48363 29397420
Lung cancer metastatic 58.29 14.80 62 128682 2365 29443418
Abdominal discomfort 57.94 14.80 74 128670 47829 29397954
Intestinal dilatation 57.60 14.80 43 128701 1017 29444766
Rectal haemorrhage 57.47 14.80 40 128704 34509 29411274
Cerebral infarction 57.29 14.80 18 128726 24657 29421126
Skin exfoliation 57.28 14.80 14 128730 22631 29423152
Fluid retention 56.87 14.80 16 128728 23544 29422239
Gastrointestinal carcinoma 56.35 14.80 45 128699 1179 29444604
Euphoric mood 56.25 14.80 86 128658 4739 29441044
Ejection fraction decreased 56.06 14.80 175 128569 15803 29429980
Drug monitoring procedure incorrectly performed 55.93 14.80 25 128719 210 29445573
Rash maculo-papular 55.90 14.80 18 128726 24271 29421512
Ventricular tachycardia 55.10 14.80 15 128729 22559 29423224
Blood triglycerides increased 55.04 14.80 151 128593 12683 29433100
Viral infection 54.57 14.80 165 128579 14645 29431138
Electrocardiogram T wave abnormal 54.50 14.80 46 128698 1305 29444478
Skin lesion 54.36 14.80 8 128736 18564 29427219
Impaired self-care 54.28 14.80 40 128704 927 29444856
Stoma site erythema 54.14 14.80 34 128710 600 29445183
Alopecia 54.10 14.80 9 128735 19075 29426708
Blood urea decreased 53.74 14.80 39 128705 882 29444901
Bronchitis 53.41 14.80 49 128695 36819 29408964
Insomnia 52.86 14.80 203 128541 88558 29357225
Osteoarthritis 52.53 14.80 8 128736 18095 29427688
Weight increased 51.84 14.80 536 128208 76131 29369652
Hypocalcaemia 51.84 14.80 13 128731 20652 29425131
Pericardial effusion 51.71 14.80 206 128538 21002 29424781
Type 2 diabetes mellitus 51.64 14.80 153 128591 13428 29432355
Full blood count decreased 51.47 14.80 5 128739 15987 29429796
Multiple organ dysfunction syndrome 51.40 14.80 125 128619 62991 29382792
Myelodysplastic syndrome 51.32 14.80 8 128736 17786 29427997
Nephrolithiasis 51.26 14.80 23 128721 25311 29420472
Cholestasis 51.21 14.80 19 128725 23443 29422340
Hyponatraemia 51.19 14.80 139 128605 67494 29378289
Sexual dysfunction 50.78 14.80 91 128653 5723 29440060
Sedation complication 50.39 14.80 43 128701 1239 29444544
Basal cell carcinoma 50.16 14.80 7 128737 16903 29428880
Hallucination 50.11 14.80 350 128394 44362 29401421
Polydipsia psychogenic 49.96 14.80 19 128725 100 29445683
Blood creatinine increased 49.80 14.80 196 128548 84906 29360877
Coronary artery disease 49.67 14.80 72 128672 44118 29401665
Rash erythematous 49.58 14.80 16 128728 21546 29424237
Metabolic syndrome 49.10 14.80 45 128699 1428 29444355
Visual impairment 48.62 14.80 35 128709 29673 29416110
Refusal of treatment by patient 48.28 14.80 79 128665 4615 29441168
Basophil count increased 48.09 14.80 28 128716 428 29445355
Increased appetite 48.03 14.80 91 128653 5973 29439810
Globulins decreased 47.96 14.80 21 128723 167 29445616
Lymphoma 47.60 14.80 121 128623 9707 29436076
Bone pain 47.47 14.80 11 128733 18441 29427342
Coagulopathy 47.44 14.80 10 128734 17897 29427886
Haemoptysis 47.42 14.80 38 128706 30512 29415271
Red blood cell count increased 47.33 14.80 43 128701 1349 29444434
Obsessive thoughts 47.29 14.80 31 128713 591 29445192
Hyperbilirubinaemia 47.20 14.80 5 128739 14929 29430854
Blister 47.16 14.80 14 128730 19892 29425891
Delusion of grandeur 47.11 14.80 27 128717 400 29445383
Suspiciousness 46.65 14.80 24 128720 283 29445500
Drug-induced liver injury 46.49 14.80 18 128726 21637 29424146
Withdrawal catatonia 46.42 14.80 17 128727 79 29445704
Mean cell haemoglobin concentration increased 45.78 14.80 24 128720 295 29445488
Hepatic failure 45.50 14.80 42 128702 31470 29414313
Heart rate decreased 45.34 14.80 26 128718 24886 29420897
Therapeutic product effect decreased 45.26 14.80 37 128707 29414 29416369
Pulmonary valve incompetence 45.21 14.80 32 128712 695 29445088
Hepatic function abnormal 45.08 14.80 63 128681 39196 29406587
Diverticulitis 44.67 14.80 11 128733 17693 29428090
Fibroma 44.65 14.80 22 128722 235 29445548
Visual acuity reduced 44.50 14.80 6 128738 14870 29430913
Neutrophil count normal 44.41 14.80 10 128734 0 29445783
Cataract 44.22 14.80 21 128723 22357 29423426
Neck pain 44.14 14.80 19 128725 21428 29424355
Neutrophil count 44.09 14.80 11 128733 6 29445777
Gout 43.67 14.80 10 128734 16901 29428882
Haemorrhage intracranial 43.18 14.80 6 128738 14536 29431247
Abdominal pain 43.16 14.80 379 128365 134978 29310805
Device related infection 42.95 14.80 8 128736 15628 29430155
Tinnitus 42.87 14.80 8 128736 15606 29430177
Red cell distribution width increased 42.82 14.80 75 128669 4632 29441151
Contusion 41.95 14.80 44 128700 31051 29414732
Deep vein thrombosis 41.92 14.80 120 128624 57279 29388504
Bundle branch block right 41.57 14.80 91 128653 6626 29439157
Diplopia 41.53 14.80 5 128739 13513 29432270
Stoma site inflammation 41.51 14.80 25 128719 408 29445375
Candida infection 41.38 14.80 8 128736 15217 29430566
Condition aggravated 41.37 14.80 422 128322 145873 29299910
Nasopharyngitis 41.23 14.80 128 128616 59537 29386246
Gastrointestinal necrosis 41.21 14.80 58 128686 2964 29442819
Stoma site reaction 41.13 14.80 18 128726 143 29445640
Bradykinesia 40.98 14.80 62 128682 3385 29442398
Hypotension 40.80 14.80 598 128146 193756 29252027
Disseminated intravascular coagulation 40.64 14.80 18 128726 19962 29425821
Ventricular hypokinesia 40.57 14.80 72 128672 4493 29441290
Prostatic specific antigen increased 40.24 14.80 4 128740 12560 29433223
Dysphemia 40.17 14.80 40 128704 1410 29444373
Diabetes mellitus 40.15 14.80 304 128440 39527 29406256
Staphylococcal infection 39.87 14.80 41 128703 29199 29416584
Arteriosclerosis coronary artery 39.87 14.80 119 128625 10486 29435297
Drowning 39.83 14.80 24 128720 392 29445391
Dilatation ventricular 39.64 14.80 51 128693 2389 29443394
Wrong technique in product usage process 39.63 14.80 47 128697 31381 29414402
Lip swelling 39.62 14.80 4 128740 12406 29433377
Urinary incontinence 39.30 14.80 159 128585 16322 29429461
Septic shock 39.25 14.80 140 128604 62420 29383363
Drug eruption 39.25 14.80 12 128732 16729 29429054
Drug intolerance 39.23 14.80 96 128648 48283 29397500
Osteonecrosis 39.16 14.80 6 128738 13513 29432270
Flushing 39.14 14.80 41 128703 28951 29416832
Jaundice 38.91 14.80 42 128702 29254 29416529
Rebound effect 38.71 14.80 46 128698 1985 29443798
Acute psychosis 38.59 14.80 42 128702 1645 29444138
Hypoacusis 38.32 14.80 8 128736 14415 29431368
Upper gastrointestinal haemorrhage 38.30 14.80 24 128720 21890 29423893
Drug dose titration not performed 38.28 14.80 20 128724 244 29445539
Burning sensation 38.14 14.80 11 128733 15927 29429856
Red cell distribution width decreased 38.09 14.80 18 128726 174 29445609
Angina pectoris 38.03 14.80 39 128705 27811 29417972
Product quality issue 37.98 14.80 11 128733 15884 29429899
Ankle fracture 37.79 14.80 60 128684 3416 29442367
Waist circumference increased 37.54 14.80 29 128715 723 29445060
Toxic epidermal necrolysis 37.49 14.80 16 128728 18137 29427646
Swelling face 37.38 14.80 21 128723 20329 29425454
Loss of libido 37.32 14.80 48 128696 2248 29443535
Suicidal ideation 37.29 14.80 269 128475 34447 29411336
Pleurothotonus 37.14 14.80 33 128711 1005 29444778
Hypersplenism 37.13 14.80 21 128723 303 29445480
Rhinorrhoea 37.01 14.80 24 128720 21495 29424288
Respiratory failure 36.99 14.80 259 128485 96872 29348911
Hypervolaemia 36.98 14.80 15 128729 17530 29428253
Waxy flexibility 36.88 14.80 15 128729 97 29445686
Left atrial dilatation 36.74 14.80 41 128703 1652 29444131
Eosinophilic colitis 36.56 14.80 18 128726 192 29445591
Drug level changed 36.36 14.80 21 128723 316 29445467
Foetal exposure during pregnancy 36.30 14.80 57 128687 33810 29411973
Dysuria 35.99 14.80 27 128717 22413 29423370
Epilepsy 35.68 14.80 167 128577 18265 29427518
Faecal vomiting 35.65 14.80 22 128722 376 29445407
Obsessive-compulsive symptom 35.58 14.80 14 128730 82 29445701
QRS axis abnormal 35.26 14.80 33 128711 1076 29444707
Electroencephalogram abnormal 35.14 14.80 47 128697 2288 29443495
Hepatotoxicity 34.94 14.80 17 128727 17850 29427933
Monocytosis 34.75 14.80 21 128723 345 29445438
Neoplasm progression 34.48 14.80 19 128725 18593 29427190
Urinary tract infection 34.40 14.80 473 128271 71881 29373902
Bacteraemia 34.33 14.80 14 128730 16309 29429474
Viral myocarditis 34.08 14.80 15 128729 121 29445662
Nasal congestion 33.94 14.80 20 128724 18859 29426924
Dry mouth 33.93 14.80 27 128717 21757 29424026
Inappropriate affect 33.91 14.80 24 128720 521 29445262
Total cholesterol/HDL ratio increased 33.83 14.80 16 128728 155 29445628
Lymphocytosis 33.82 14.80 42 128702 1898 29443885
Product prescribing error 33.82 14.80 18 128726 17958 29427825
Acute respiratory distress syndrome 33.79 14.80 30 128714 22905 29422878
Posture abnormal 33.70 14.80 42 128702 1905 29443878
Lymphocyte percentage increased 33.61 14.80 17 128727 193 29445590
Dysphonia 33.58 14.80 21 128723 19175 29426608
Fungal infection 33.57 14.80 9 128735 13676 29432107
Oxygen saturation decreased 33.51 14.80 93 128651 44844 29400939
Pleural effusion 33.50 14.80 180 128564 71728 29374055
Prostate cancer 33.46 14.80 37 128707 25490 29420293
Feeling abnormal 33.38 14.80 123 128621 54322 29391461
Mania 33.32 14.80 98 128646 8565 29437218
Oesophageal carcinoma 33.28 14.80 66 128678 4481 29441302
Ischaemic stroke 33.12 14.80 14 128730 15963 29429820
Chronic kidney disease 33.00 14.80 68 128676 36348 29409435
Dyspepsia 32.95 14.80 50 128694 30075 29415708
Premature baby 32.95 14.80 17 128727 17263 29428520
Spleen congestion 32.66 14.80 19 128725 290 29445493
Encephalopathy 32.56 14.80 53 128691 30990 29414793
Leukaemia 32.46 14.80 59 128685 3751 29442032
Brain injury 32.23 14.80 73 128671 5439 29440344
Malignant catatonia 32.08 14.80 17 128727 214 29445569
Volvulus 31.93 14.80 32 128712 1137 29444646
Clostridium difficile colitis 31.83 14.80 9 128735 13203 29432580
Monocyte count decreased 31.74 14.80 31 128713 1067 29444716
Bone marrow failure 31.56 14.80 44 128700 27405 29418378
Toxic skin eruption 31.53 14.80 3 128741 9754 29436029
Blood cholesterol increased 31.44 14.80 143 128601 15452 29430331
Neuralgia 31.10 14.80 5 128739 10869 29434914
Blood pressure decreased 31.10 14.80 98 128646 45379 29400404
Angina unstable 31.07 14.80 5 128739 10860 29434923
Chest discomfort 30.81 14.80 100 128644 45883 29399900
Shock haemorrhagic 30.70 14.80 3 128741 9548 29436235
Dysarthria 30.63 14.80 235 128509 30676 29415107
Suspected COVID-19 30.63 14.80 23 128721 549 29445234
Sopor 30.60 14.80 111 128633 10823 29434960
SARS-CoV-2 test positive 30.57 14.80 53 128691 3246 29442537
Lower limb fracture 30.42 14.80 56 128688 3596 29442187
Chromaturia 30.33 14.80 9 128735 12793 29432990
Granulocytosis 30.29 14.80 16 128728 200 29445583
Blood lactate dehydrogenase decreased 30.22 14.80 15 128729 163 29445620
Flatulence 30.12 14.80 20 128724 17689 29428094
Myelosuppression 30.07 14.80 8 128736 12219 29433564
Loss of personal independence in daily activities 30.03 14.80 40 128704 25400 29420383
Polydipsia 29.96 14.80 54 128690 3411 29442372
Haemodialysis 29.81 14.80 4 128740 9950 29435833
Electrocardiogram T wave inversion 29.75 14.80 40 128704 1957 29443826
Gastric ulcer 29.67 14.80 12 128732 14049 29431734
Ventricular fibrillation 29.57 14.80 16 128728 15817 29429966
Suicidal behaviour 29.52 14.80 33 128711 1332 29444451
Electrocardiogram change 29.48 14.80 23 128721 582 29445201
Clostridium difficile infection 29.15 14.80 17 128727 16124 29429659
Pulmonary hypertension 29.06 14.80 23 128721 18585 29427198
Presyncope 28.98 14.80 17 128727 16072 29429711
Discomfort 28.94 14.80 14 128730 14749 29431034
Anion gap increased 28.83 14.80 35 128709 1545 29444238
Treatment failure 28.63 14.80 75 128669 36864 29408919
Testis cancer 28.53 14.80 27 128717 893 29444890
Blood disorder 28.53 14.80 48 128696 2869 29442914
Cardiac failure 28.45 14.80 215 128529 79072 29366711
Feeling hot 28.42 14.80 16 128728 15472 29430311
Hypercalcaemia 28.41 14.80 10 128734 12749 29433034
Appendicitis perforated 28.30 14.80 36 128708 1667 29444116
Dementia 28.22 14.80 113 128631 11545 29434238
Joint stiffness 27.91 14.80 4 128740 9469 29436314
Hypoxia 27.77 14.80 109 128635 47270 29398513
Water intoxication 27.77 14.80 19 128725 390 29445393
Hypothermia 27.75 14.80 96 128648 9143 29436640
Depression 27.74 14.80 237 128507 84910 29360873
Throat irritation 27.61 14.80 3 128741 8782 29437001
Incontinence 27.61 14.80 65 128679 4967 29440816
Infection 27.38 14.80 478 128266 76273 29369510
Appendicectomy 27.28 14.80 25 128719 793 29444990
Eczema 27.27 14.80 13 128731 13813 29431970
Blood creatinine decreased 27.05 14.80 44 128700 2557 29443226
Learning disability 27.02 14.80 17 128727 301 29445482
Gamma-glutamyltransferase increased 26.90 14.80 204 128540 26533 29419250
Drug dependence 26.85 14.80 31 128713 20950 29424833
Tricuspid valve incompetence 26.78 14.80 89 128655 8305 29437478
Skin discolouration 26.75 14.80 17 128727 15392 29430391
Proteinuria 26.67 14.80 18 128726 15786 29429997
Ocular hyperaemia 26.55 14.80 4 128740 9123 29436660
Nephropathy toxic 26.53 14.80 7 128737 10749 29435034
Reduced facial expression 26.37 14.80 23 128721 683 29445100
Acute myeloid leukaemia 26.31 14.80 20 128724 16493 29429290
Hyperprolactinaemia 26.27 14.80 30 128714 1240 29444543
Electrocardiogram QT interval abnormal 26.20 14.80 11 128733 78 29445705
Skin ulcer 26.16 14.80 26 128718 18814 29426969
Productive cough 26.16 14.80 61 128683 31198 29414585
Blood bilirubin increased 26.13 14.80 69 128675 33824 29411959
Mutism 26.06 14.80 23 128721 694 29445089
Blood test abnormal 26.01 14.80 69 128675 5680 29440103
Blindness 25.79 14.80 10 128734 12013 29433770
Testicular germ cell cancer metastatic 25.79 14.80 10 128734 56 29445727
Chronic hepatitis C 25.75 14.80 17 128727 328 29445455
Enterococcal infection 25.54 14.80 3 128741 8265 29437518
Neurotoxicity 25.54 14.80 16 128728 14597 29431186
Patient restraint 25.50 14.80 11 128733 84 29445699
Haemolytic anaemia 25.49 14.80 5 128739 9414 29436369
Delusional perception 25.37 14.80 13 128731 152 29445631
Pseudophaeochromocytoma 25.34 14.80 7 128737 9 29445774
Restlessness 25.18 14.80 174 128570 21971 29423812
Oral pain 25.06 14.80 5 128739 9302 29436481
Pseudomonas infection 25.04 14.80 8 128736 10844 29434939
Hot flush 25.01 14.80 17 128727 14853 29430930
Subacute endocarditis 24.89 14.80 9 128735 40 29445743
Hypoalbuminaemia 24.86 14.80 7 128737 10298 29435485
Frequent bowel movements 24.80 14.80 5 128739 9234 29436549
Hyperglycaemia 24.79 14.80 72 128672 34215 29411568
Purpura 24.77 14.80 5 128739 9227 29436556
Dyslipidaemia 24.69 14.80 70 128674 5991 29439792
Conduction disorder 24.63 14.80 35 128709 1805 29443978
Bundle branch block left 24.55 14.80 64 128680 5213 29440570
Personality change 24.46 14.80 59 128685 4579 29441204
Rash papular 24.40 14.80 3 128741 7978 29437805
Amnesia 24.36 14.80 38 128706 22605 29423178
Dementia with Lewy bodies 24.26 14.80 21 128723 617 29445166
Lymphadenopathy 24.23 14.80 45 128699 25004 29420779
Seminoma 24.22 14.80 14 128730 211 29445572
Confusional state 24.13 14.80 728 128016 127149 29318634
Migraine 24.04 14.80 12 128732 12418 29433365
Drug abuse 23.98 14.80 227 128517 79656 29366127
Akinesia 23.95 14.80 36 128708 1954 29443829
Hyperkinesia 23.78 14.80 32 128712 1567 29444216
Empyema 23.63 14.80 43 128701 2736 29443047
Tension 23.58 14.80 35 128709 1878 29443905
Encephalitis toxic 23.53 14.80 15 128729 272 29445511
Pulmonary fibrosis 23.42 14.80 20 128724 15562 29430221
Staphylococcal sepsis 23.37 14.80 5 128739 8857 29436926
Erythema multiforme 23.35 14.80 3 128741 7714 29438069
Renal tubular necrosis 23.24 14.80 17 128727 14298 29431485
Delusional disorder, unspecified type 23.19 14.80 21 128723 656 29445127
End stage renal disease 23.14 14.80 3 128741 7661 29438122
Aortic dilatation 23.08 14.80 25 128719 974 29444809
Gastric haemorrhage 23.02 14.80 6 128738 9291 29436492
Amylase decreased 22.99 14.80 8 128736 31 29445752
Tangentiality 22.96 14.80 11 128733 110 29445673
Contraindicated product administered 22.86 14.80 147 128597 18119 29427664
Skin disorder 22.80 14.80 11 128733 11607 29434176
Blood osmolarity decreased 22.78 14.80 19 128725 530 29445253
Excessive masturbation 22.68 14.80 10 128734 81 29445702
Intervertebral disc protrusion 22.64 14.80 5 128739 8665 29437118
Illusion 22.53 14.80 21 128723 681 29445102
Pickwickian syndrome 22.42 14.80 9 128735 56 29445727
Blunted affect 22.39 14.80 15 128729 297 29445486
Substance use 22.30 14.80 18 128726 479 29445304
Testicular cancer metastatic 22.29 14.80 9 128735 57 29445726
Intestinal ischaemia 22.29 14.80 72 128672 6620 29439163
Therapy non-responder 22.28 14.80 65 128679 30846 29414937
Non-Hodgkin's lymphoma unspecified histology aggressive 22.21 14.80 5 128739 0 29445783
Deafness 22.18 14.80 8 128736 10047 29435736
Nightmare 22.12 14.80 11 128733 11406 29434377
Anuria 22.07 14.80 7 128737 9534 29436249
Hypersensitivity myocarditis 22.05 14.80 8 128736 36 29445747
Swollen tongue 22.04 14.80 13 128731 12253 29433530
Anisocytosis 21.85 14.80 16 128728 367 29445416
Throat cancer 21.78 14.80 22 128722 789 29444994
Nervousness 21.74 14.80 11 128733 11295 29434488
Alcohol abuse 21.67 14.80 54 128690 4279 29441504
Polyneuropathy 21.66 14.80 13 128731 12139 29433644
Blood pressure increased 21.61 14.80 211 128533 73592 29372191
Mean cell haemoglobin increased 21.57 14.80 26 128718 1139 29444644
Haematology test abnormal 21.48 14.80 7 128737 21 29445762
Haemorrhoids 21.45 14.80 12 128732 11645 29434138
Osteomyelitis 21.34 14.80 17 128727 13692 29432091
Fall 21.32 14.80 959 127785 176219 29269564
Cardiomegaly 21.18 14.80 117 128627 13659 29432124
High-grade B-cell lymphoma 21.06 14.80 9 128735 67 29445716
Urine output decreased 20.98 14.80 7 128737 9231 29436552
Acne 20.92 14.80 7 128737 9213 29436570
Medication error 20.87 14.80 161 128583 21050 29424733
Withdrawal syndrome 20.84 14.80 99 128645 10893 29434890
Transaminases increased 20.80 14.80 42 128702 22620 29423163
Quarantine 20.78 14.80 7 128737 24 29445759
Obstructive airways disorder 20.76 14.80 11 128733 11005 29434778
Cardio-respiratory arrest 20.71 14.80 132 128612 50469 29395314
Atrial flutter 20.67 14.80 18 128726 13876 29431907
Blood osmolarity increased 20.56 14.80 15 128729 342 29445441
Crush syndrome 20.45 14.80 8 128736 46 29445737
Ideas of reference 20.45 14.80 8 128736 46 29445737
Product use in unapproved indication 20.44 14.80 261 128483 86614 29359169
Lacrimation increased 20.44 14.80 3 128741 6977 29438806
Psychotic behaviour 20.42 14.80 19 128725 615 29445168
Myocardial fibrosis 20.04 14.80 24 128720 1044 29444739
Anticholinergic syndrome 20.00 14.80 22 128722 872 29444911
Skin cancer 19.97 14.80 6 128738 8462 29437321
Oliguria 19.92 14.80 4 128740 7408 29438375
Face oedema 19.78 14.80 10 128734 10273 29435510
Heat stroke 19.70 14.80 22 128722 887 29444896
Colitis ulcerative 19.67 14.80 16 128728 12753 29433030
Bipolar disorder 19.67 14.80 44 128700 3251 29442532
Blood creatine phosphokinase decreased 19.53 14.80 16 128728 435 29445348
Intentional product misuse 19.52 14.80 81 128663 34580 29411203
Electroconvulsive therapy 19.48 14.80 6 128738 14 29445769
Liver function test increased 19.44 14.80 14 128730 11871 29433912
Hyperosmolar state 19.41 14.80 15 128729 374 29445409
Pulmonary haemorrhage 19.41 14.80 8 128736 9262 29436521
Alcohol problem 19.41 14.80 9 128735 83 29445700
Electrocardiogram ST segment elevation 19.40 14.80 53 128691 4439 29441344
Haematotoxicity 19.34 14.80 3 128741 6696 29439087
Autism spectrum disorder 19.30 14.80 33 128711 1999 29443784
Thought blocking 19.21 14.80 10 128734 121 29445662
Blood sodium increased 19.20 14.80 38 128706 2576 29443207
Subdural haematoma 19.13 14.80 31 128713 18162 29427621
Affective disorder 18.95 14.80 42 128702 3084 29442699
Hypertension 18.84 14.80 376 128368 116238 29329545
Rash macular 18.80 14.80 11 128733 10414 29435369
Gastrooesophageal reflux disease 18.75 14.80 72 128672 31424 29414359
Lymphocyte morphology abnormal 18.63 14.80 16 128728 465 29445318
Large intestine polyp 18.60 14.80 3 128741 6506 29439277
Exposure during pregnancy 18.54 14.80 7 128737 8547 29437236
Osteoporosis 18.53 14.80 12 128732 10757 29435026
Drop attacks 18.48 14.80 17 128727 542 29445241
Musculoskeletal stiffness 18.43 14.80 92 128652 37366 29408417
Somnolence neonatal 18.41 14.80 6 128738 18 29445765
Hepatic enzyme increased 18.41 14.80 80 128664 33719 29412064
Incoherent 18.40 14.80 49 128695 4043 29441740
Brain neoplasm 18.40 14.80 39 128705 2777 29443006
Embedded device 18.34 14.80 12 128732 228 29445555
Rib fracture 18.30 14.80 17 128727 12701 29433082
Hepatocellular injury 18.14 14.80 41 128703 21202 29424581
Hepatic encephalopathy 18.08 14.80 18 128726 13017 29432766
Unresponsive to stimuli 18.08 14.80 178 128566 24948 29420835
Cardiac dysfunction 18.03 14.80 30 128714 1777 29444006
Spinal osteoarthritis 18.01 14.80 3 128741 6353 29439430
Hiccups 17.97 14.80 8 128736 8845 29436938
Stoma site extravasation 17.92 14.80 8 128736 67 29445716
Carditis 17.88 14.80 9 128735 101 29445682
Myopathy 17.77 14.80 12 128732 10521 29435262
Foreign body ingestion 17.77 14.80 4 128740 0 29445783
Blood cannabinoids 17.77 14.80 4 128740 0 29445783
Thalassaemia 17.77 14.80 4 128740 0 29445783
Eosinopenia 17.77 14.80 4 128740 0 29445783
Judgement impaired 17.65 14.80 17 128727 575 29445208
Gender dysphoria 17.38 14.80 7 128737 44 29445739
Stoma site odour 17.29 14.80 6 128738 23 29445760
Electrocardiogram T wave amplitude decreased 17.28 14.80 11 128733 199 29445584
Alcohol detoxification 17.25 14.80 7 128737 45 29445738
Retrograde ejaculation 17.21 14.80 13 128731 313 29445470
Coprolalia 17.10 14.80 6 128738 24 29445759
Compensatory sweating 17.10 14.80 6 128738 24 29445759
Oral candidiasis 17.06 14.80 13 128731 10709 29435074
Red blood cell sedimentation rate increased 17.01 14.80 71 128673 7390 29438393
Throat tightness 16.77 14.80 5 128739 7086 29438697
Catecholamines urine increased 16.76 14.80 5 128739 10 29445773
Basilar migraine 16.76 14.80 5 128739 10 29445773
Cardiac septal hypertrophy 16.74 14.80 12 128732 266 29445517
Hepatic steatosis 16.73 14.80 117 128627 14829 29430954
Laparotomy 16.66 14.80 12 128732 268 29445515
Cholangitis 16.62 14.80 6 128738 7531 29438252
Memory impairment 16.58 14.80 92 128652 36378 29409405
Cellulitis 16.58 14.80 124 128620 45716 29400067
Wrong patient received product 16.55 14.80 33 128711 2249 29443534
Blood pressure systolic increased 16.52 14.80 30 128714 16815 29428968
Cholinergic syndrome 16.50 14.80 15 128729 471 29445312
Vertigo 16.47 14.80 45 128699 21816 29423967
Acidosis 16.45 14.80 11 128733 9694 29436089
Norepinephrine increased 16.44 14.80 5 128739 11 29445772
Systolic dysfunction 16.41 14.80 32 128712 2146 29443637
Chronic obstructive pulmonary disease 16.41 14.80 260 128484 40695 29405088
Peripheral sensory neuropathy 16.39 14.80 3 128741 5936 29439847
Colitis 16.39 14.80 75 128669 31173 29414610
Pancreatitis acute 16.35 14.80 53 128691 24332 29421451
Cardiac failure chronic 16.35 14.80 4 128740 6463 29439320
Mean cell volume abnormal 16.32 14.80 12 128732 277 29445506
Postmortem blood drug level increased 16.32 14.80 11 128733 220 29445563
Duodenal ulcer 16.30 14.80 10 128734 9228 29436555
Haemolysis 16.28 14.80 5 128739 6951 29438832
Dermatitis bullous 16.27 14.80 3 128741 5903 29439880
Stab wound 16.24 14.80 11 128733 222 29445561
Flank pain 16.22 14.80 3 128741 5890 29439893
Liver disorder 16.16 14.80 64 128680 27685 29418098
Eye disorder 16.02 14.80 7 128737 7827 29437956
Limb discomfort 16.01 14.80 11 128733 9557 29436226
Myelocyte count increased 15.98 14.80 13 128731 350 29445433
Viral pericarditis 15.87 14.80 6 128738 31 29445752
Subileus 15.84 14.80 37 128707 2813 29442970
Musculoskeletal chest pain 15.81 14.80 9 128735 8651 29437132
Substance abuse 15.80 14.80 65 128679 6722 29439061
Mean platelet volume increased 15.74 14.80 14 128730 427 29445356
Cogwheel rigidity 15.69 14.80 23 128721 1220 29444563
Peritonitis bacterial 15.69 14.80 3 128741 5753 29440030
Stupor 15.66 14.80 36 128708 2708 29443075
ECG signs of myocardial ischaemia 15.61 14.80 10 128734 183 29445600
Squamous cell carcinoma 15.60 14.80 13 128731 10238 29435545
Stoma site oedema 15.54 14.80 4 128740 3 29445780
Self-induced vomiting 15.54 14.80 4 128740 3 29445780
Alcoholic seizure 15.54 14.80 4 128740 3 29445780
Somatic delusion 15.50 14.80 8 128736 95 29445688
Benign prostatic hyperplasia 15.31 14.80 17 128727 11693 29434090
Device malfunction 15.31 14.80 9 128735 8498 29437285
Enterocolitis 15.23 14.80 5 128739 6661 29439122
Flat affect 15.20 14.80 18 128726 774 29445009
Blood urea nitrogen/creatinine ratio decreased 15.13 14.80 6 128738 36 29445747
Ileus 15.11 14.80 111 128633 14291 29431492
Somatic dysfunction 15.10 14.80 5 128739 16 29445767
Eating disorder 15.02 14.80 67 128677 7180 29438603
Infantile back arching 15.01 14.80 4 128740 4 29445779
Hemiplegia 14.97 14.80 5 128739 6589 29439194
Behaviour disorder 14.96 14.80 42 128702 3574 29442209
Sinus rhythm 14.96 14.80 11 128733 254 29445529
Aplastic anaemia 14.91 14.80 7 128737 7503 29438280
Stoma site discomfort 14.87 14.80 5 128739 17 29445766
Status epilepticus 14.87 14.80 15 128729 10779 29435004
Disorientation 14.85 14.80 195 128549 29320 29416463
Generalised oedema 14.83 14.80 16 128728 11149 29434634

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 17193.38 14.93 9114 140358 230510 64118750
Neutrophil count increased 6315.01 14.93 2324 147148 22850 64326410
Neutrophilia 5485.78 14.93 1523 147949 5171 64344089
Granulocytopenia 5345.83 14.93 1649 147823 8791 64340469
White blood cell count increased 5306.67 14.93 2728 146744 63286 64285974
Differential white blood cell count abnormal 3286.42 14.93 777 148695 1033 64348227
Antipsychotic drug level increased 2316.25 14.93 736 148736 4379 64344881
Death 2078.79 14.93 3871 145601 478834 63870426
White blood cell count decreased 2004.32 14.93 2133 147339 155704 64193556
Salivary hypersecretion 1970.56 14.93 818 148654 11295 64337965
Hospitalisation 1967.56 14.93 1527 147945 73680 64275580
Myocarditis 1893.14 14.93 880 148592 16163 64333097
Neutrophil count decreased 1797.94 14.93 1464 148008 75732 64273528
Agranulocytosis 1610.60 14.93 1039 148433 37190 64312070
Leukopenia 1412.27 14.93 1440 148032 99802 64249458
Psychotic disorder 1366.51 14.93 903 148569 33675 64315585
Sedation 1227.42 14.93 907 148565 40555 64308705
Neuroleptic malignant syndrome 1202.06 14.93 739 148733 24257 64325003
Mental impairment 1063.46 14.93 588 148884 15755 64333505
Platelet count increased 989.80 14.93 588 148884 18108 64331152
Tachycardia 760.12 14.93 1294 148178 148285 64200975
Leukocytosis 754.37 14.93 656 148816 37084 64312176
Pain 733.90 14.93 190 149282 553321 63795939
Arthralgia 731.26 14.93 85 149387 442175 63907085
Nausea 678.06 14.93 502 148970 785298 63563962
Rash 652.01 14.93 135 149337 458414 63890846
Hallucination, auditory 646.26 14.93 433 149039 16506 64332754
Antipsychotic drug level decreased 642.68 14.93 186 149286 758 64348502
Anosognosia 629.18 14.93 239 149233 2566 64346694
Headache 611.92 14.93 232 149240 529235 63820025
Antipsychotic drug level above therapeutic 591.04 14.93 205 149267 1656 64347604
Schizophrenia 567.02 14.93 342 149130 10826 64338434
Delusion 564.30 14.93 408 149064 17606 64331654
Eosinophil count increased 563.14 14.93 371 149101 13741 64335519
Pruritus 561.11 14.93 43 149429 312357 64036903
Treatment noncompliance 556.06 14.93 591 148881 42891 64306369
Blood prolactin abnormal 545.86 14.93 214 149258 2518 64346742
Catatonia 545.12 14.93 292 149180 7328 64341932
Haemoglobin decreased 530.89 14.93 1303 148169 193760 64155500
C-reactive protein increased 525.79 14.93 854 148618 94055 64255205
Fatigue 520.77 14.93 583 148889 748147 63601113
Troponin increased 517.40 14.93 364 149108 15035 64334225
Dystonia 505.40 14.93 389 149083 18476 64330784
Dyskinesia 503.00 14.93 535 148937 38853 64310407
Disturbance in social behaviour 495.37 14.93 221 149251 3666 64345594
Diarrhoea 489.18 14.93 575 148897 722129 63627131
Eosinophil count decreased 475.07 14.93 192 149280 2460 64346800
Antipsychotic drug level below therapeutic 446.88 14.93 142 149330 843 64348417
Pre-existing disease 422.80 14.93 97 149375 101 64349159
Sexual dysfunction 421.33 14.93 233 149239 6238 64343022
Dyspnoea 415.01 14.93 642 148830 718032 63631228
Pain in extremity 410.63 14.93 99 149373 302986 64046274
Joint swelling 409.22 14.93 22 149450 215360 64133900
Monocyte count increased 406.49 14.93 246 149226 7833 64341427
Metabolic disorder 404.45 14.93 241 149231 7456 64341804
Sinus tachycardia 394.76 14.93 428 149044 31760 64317500
Blood creatine phosphokinase increased 393.04 14.93 576 148896 57982 64291278
Drug level increased 376.88 14.93 430 149042 33766 64315494
Drug hypersensitivity 361.10 14.93 59 149413 237756 64111504
Peripheral swelling 350.62 14.93 38 149434 209115 64140145
Rheumatoid arthritis 350.31 14.93 6 149466 164288 64184972
Faecaloma 319.94 14.93 227 149245 9501 64339759
Personality change 316.58 14.93 215 149257 8378 64340882
Eosinophilia 314.56 14.93 414 149058 37662 64311598
Back pain 310.11 14.93 97 149375 250074 64099186
Lymphocyte count increased 307.17 14.93 173 149299 4802 64344458
Alopecia 296.67 14.93 23 149449 165667 64183593
Erythema 294.00 14.93 42 149430 187028 64162232
Suicide attempt 292.14 14.93 561 148911 70446 64278814
Pneumonia aspiration 291.61 14.93 506 148966 58765 64290495
Platelet count decreased 290.58 14.93 952 148520 166759 64182501
Swelling 290.39 14.93 21 149451 160197 64189063
Urticaria 283.04 14.93 14 149458 147303 64201957
Asthenia 281.89 14.93 347 149125 427697 63921563
Extrapyramidal disorder 279.10 14.93 282 149190 19270 64329990
Mean cell haemoglobin decreased 272.69 14.93 150 149322 3972 64345288
Hypersensitivity 272.18 14.93 61 149411 196391 64152869
Mental disorder 270.40 14.93 320 149152 26125 64323135
Aggression 269.49 14.93 426 149046 45806 64303454
Sinusitis 267.73 14.93 18 149454 145910 64203350
Psychiatric decompensation 266.56 14.93 125 149347 2338 64346922
Acute kidney injury 264.68 14.93 395 149077 448845 63900415
Electrocardiogram QT prolonged 258.76 14.93 570 148902 78878 64270382
Agitation 252.45 14.93 602 148870 87765 64261495
Mean cell volume decreased 246.97 14.93 133 149339 3373 64345887
Paranoia 246.59 14.93 243 149229 16109 64333151
Lymphocyte count decreased 244.12 14.93 380 149092 40319 64308941
Obsessive-compulsive disorder 243.14 14.93 147 149325 4671 64344589
Muscle rigidity 238.47 14.93 246 149226 17227 64332033
Drooling 234.73 14.93 149 149323 5170 64344090
Malignant neoplasm progression 233.14 14.93 6 149466 112865 64236395
Arthropathy 227.65 14.93 13 149459 120954 64228306
Abdominal discomfort 227.10 14.93 70 149402 182252 64167008
Injection site pain 226.14 14.93 7 149465 111401 64237859
Red blood cell count decreased 223.68 14.93 402 149070 47984 64301276
Stomatitis 222.07 14.93 7 149465 109598 64239662
Abnormal behaviour 218.71 14.93 326 149146 33296 64315964
Febrile neutropenia 218.17 14.93 81 149391 187576 64161684
Gastrointestinal hypomotility 215.93 14.93 97 149375 1636 64347624
Akathisia 211.77 14.93 191 149281 11319 64337941
Psychotic symptom 208.48 14.93 101 149371 2037 64347223
Decreased appetite 206.93 14.93 208 149264 281081 64068179
Drug interaction 204.35 14.93 1487 147985 360596 63988664
Oedema peripheral 203.91 14.93 117 149355 210200 64139060
Overdose 202.70 14.93 819 148653 158747 64190513
Drug intolerance 200.99 14.93 92 149380 187900 64161360
Neuropathy peripheral 200.34 14.93 20 149452 117505 64231755
Off label use 200.12 14.93 773 148699 632033 63717227
Disease progression 198.20 14.93 43 149429 141637 64207623
Somnolence 195.14 14.93 961 148511 202684 64146576
Living in residential institution 193.92 14.93 67 149405 534 64348726
Hypoaesthesia 189.03 14.93 45 149427 139063 64210197
Aspiration 187.14 14.93 213 149259 16672 64332588
Enuresis 185.86 14.93 102 149370 2688 64346572
Haematocrit decreased 185.74 14.93 399 149073 54256 64295004
Nasopharyngitis 184.53 14.93 113 149359 195960 64153300
Cough 181.30 14.93 262 149210 301886 64047374
Abdominal pain upper 177.46 14.93 92 149380 174938 64174322
Generalised tonic-clonic seizure 172.65 14.93 322 149150 39535 64309725
Mean cell haemoglobin concentration decreased 172.11 14.93 107 149365 3577 64345683
Lung neoplasm malignant 169.11 14.93 228 149244 21220 64328040
Intestinal obstruction 168.37 14.93 302 149170 35984 64313276
Paraesthesia 166.84 14.93 52 149420 134470 64214790
Mean cell volume increased 166.50 14.93 118 149354 4928 64344332
Tardive dyskinesia 164.33 14.93 150 149322 9028 64340232
Muscle spasms 161.99 14.93 62 149410 140961 64208299
Epistaxis 161.39 14.93 19 149453 98112 64251148
Hyperkalaemia 160.46 14.93 22 149450 101107 64248153
Cardiomyopathy 158 14.93 241 149231 25115 64324145
On and off phenomenon 156.61 14.93 88 149384 2431 64346829
Choking 155.91 14.93 155 149317 10383 64338877
Myoclonus 154.07 14.93 237 149235 24881 64324379
Troponin T increased 153.93 14.93 85 149387 2268 64346992
Delirium 152.78 14.93 428 149044 68766 64280494
Benign ethnic neutropenia 149.32 14.93 33 149439 24 64349236
Therapeutic product effect decreased 147.76 14.93 42 149430 115309 64233951
Ileus paralytic 147.68 14.93 136 149336 8279 64340981
Haemoglobin increased 147.53 14.93 111 149361 5090 64344170
Systemic lupus erythematosus 147.06 14.93 8 149464 77604 64271656
Myalgia 144.29 14.93 95 149377 158522 64190738
Arthritis 143.52 14.93 14 149458 83800 64265460
Psychiatric symptom 141.57 14.93 117 149355 6156 64343104
Musculoskeletal pain 140.74 14.93 13 149459 81281 64267979
Orthostatic hypotension 138.39 14.93 323 149149 46415 64302845
Sudden death 138.12 14.93 200 149272 19896 64329364
Contusion 137.87 14.93 46 149426 113919 64235341
Blister 137.40 14.93 14 149458 80953 64268307
Atrial fibrillation 135.74 14.93 118 149354 170971 64178289
Glossodynia 135.27 14.93 3 149469 64693 64284567
Discomfort 134.65 14.93 15 149457 80863 64268397
Interstitial lung disease 133.97 14.93 31 149441 97701 64251559
Pleurothotonus 133.91 14.93 77 149395 2225 64347035
Intentional product use issue 133.23 14.93 29 149443 95335 64253925
Persecutory delusion 129.77 14.93 94 149378 4064 64345196
Lower respiratory tract infection 126.78 14.93 494 148978 94120 64255140
Herpes zoster 126.16 14.93 17 149455 79170 64270090
Refusal of examination 125.61 14.93 32 149440 69 64349191
Anaphylactic reaction 124.35 14.93 9 149463 68655 64280605
Pericardial effusion 123.64 14.93 278 149194 38976 64310284
Circulatory collapse 123.60 14.93 254 149218 33478 64315782
Wound 122.84 14.93 16 149456 76461 64272799
Psoriasis 122.71 14.93 12 149460 71691 64277569
Impaired healing 121.98 14.93 4 149468 60469 64288791
Blood glucose increased 120.17 14.93 498 148974 97575 64251685
International normalised ratio increased 117.04 14.93 21 149451 79146 64270114
Mucosal inflammation 113.92 14.93 8 149464 62576 64286684
Sopor 113.01 14.93 227 149245 29434 64319826
Hallucination 112.52 14.93 398 149074 72390 64276870
Neoplasm malignant 111.37 14.93 203 149269 24485 64324775
Schizoaffective disorder 111.21 14.93 60 149412 1527 64347733
Electroencephalogram abnormal 111.12 14.93 94 149378 5109 64344151
Constipation 110.27 14.93 908 148564 228429 64120831
Osteoarthritis 109.98 14.93 10 149462 63326 64285934
Psychiatric evaluation 109.76 14.93 23 149449 8 64349252
General physical condition abnormal 108.86 14.93 95 149377 5387 64343873
Megacolon 108.52 14.93 75 149397 3007 64346253
Blood prolactin increased 108.39 14.93 79 149393 3449 64345811
Drug ineffective 107.67 14.93 1340 148132 838907 63510353
Hypokalaemia 106.86 14.93 76 149396 121827 64227433
Haematochezia 106.33 14.93 14 149458 66359 64282901
Parkinsonism 106.08 14.93 148 149324 14225 64335035
Bronchitis 104.59 14.93 61 149411 108682 64240578
Dizziness 103.33 14.93 580 148892 429583 63919677
Chills 102.54 14.93 100 149372 137164 64212096
Stoma site discharge 102.51 14.93 58 149414 1624 64347636
Seizure 102.38 14.93 700 148772 166192 64183068
Left ventricular hypertrophy 102.10 14.93 118 149354 9388 64339872
Lung cancer metastatic 100.31 14.93 72 149400 3068 64346192
Freezing phenomenon 96.09 14.93 54 149418 1492 64347768
Oedema 95.11 14.93 47 149425 91888 64257372
Drug monitoring procedure incorrectly performed 92.85 14.93 35 149437 367 64348893
Dyspepsia 92.71 14.93 35 149437 80277 64268983
Oculogyric crisis 92.28 14.93 63 149409 2475 64346785
Chest discomfort 92.15 14.93 80 149392 116026 64233234
Hyperprolactinaemia 92.11 14.93 76 149396 3989 64345271
Renal failure 91.73 14.93 176 149296 181512 64167748
Left ventricular dysfunction 90.28 14.93 150 149322 16804 64332456
Rash pruritic 89.85 14.93 13 149459 57391 64291869
Migraine 89.72 14.93 18 149454 62659 64286601
Muscular weakness 89.20 14.93 98 149374 127240 64222020
Gastrointestinal haemorrhage 87.11 14.93 107 149365 132205 64217055
Metabolic syndrome 87.08 14.93 59 149413 2289 64346971
Maternal exposure during pregnancy 86.39 14.93 58 149414 95826 64253434
Hypoglycaemia 85.63 14.93 51 149421 89841 64259419
Bradykinesia 85.27 14.93 90 149382 6470 64342790
Obesity 83.93 14.93 162 149310 20400 64328860
Wheezing 83.65 14.93 41 149431 80538 64268722
Nasal congestion 83.61 14.93 18 149454 59640 64289620
Thrombosis 82.86 14.93 30 149442 70612 64278648
Electrocardiogram abnormal 82.38 14.93 127 149345 13354 64335906
Inappropriate schedule of product administration 81.58 14.93 57 149415 92229 64257031
Bone pain 81.29 14.93 8 149464 47564 64301696
Intestinal pseudo-obstruction 80.79 14.93 53 149419 1947 64347313
Dyspnoea exertional 80.43 14.93 35 149437 73695 64275565
Urinary incontinence 80.14 14.93 224 149248 35927 64313333
Hepatic enzyme increased 79.48 14.93 111 149361 129832 64219428
Stoma site erythema 78.97 14.93 44 149428 1195 64348065
Terminal state 78.33 14.93 72 149400 4372 64344888
Hypothermia 78.08 14.93 154 149318 19702 64329558
Abdominal pain 77.77 14.93 416 149056 311959 64037301
Hepatitis C 77.70 14.93 111 149361 10904 64338356
Fluid retention 77.62 14.93 21 149451 59585 64289675
Dysgeusia 77.61 14.93 9 149463 47038 64302222
Ileus 77.23 14.93 167 149305 22799 64326461
Flushing 77.22 14.93 43 149429 78605 64270655
Congestive cardiomyopathy 77.06 14.93 107 149365 10237 64339023
Monocyte count decreased 76.68 14.93 59 149413 2798 64346462
Bradycardia 76.36 14.93 97 149375 118122 64231138
Wrong patient received product 76.33 14.93 66 149406 3696 64345564
Body temperature increased 76.24 14.93 222 149250 36444 64312816
Blood urea decreased 76.08 14.93 58 149414 2713 64346547
Gastrointestinal disorder 75.93 14.93 58 149414 89651 64259609
Plasma cell myeloma 75.55 14.93 9 149463 46066 64303194
Blood triglycerides increased 75.01 14.93 147 149325 18719 64330541
Weight decreased 74.80 14.93 374 149098 285365 64063895
Pain in jaw 74.78 14.93 5 149467 40750 64308510
Refusal of treatment by patient 74.04 14.93 94 149378 8245 64341015
Insurance issue 72.89 14.93 57 149415 2769 64346491
Neck pain 72.39 14.93 26 149446 61507 64287753
Treatment failure 72.23 14.93 99 149373 116717 64232543
Red cell distribution width increased 71.10 14.93 113 149359 12196 64337064
Multiple sclerosis relapse 70.07 14.93 7 149465 41128 64308132
Fibromyalgia 69.87 14.93 3 149469 35728 64313532
Epilepsy 69.69 14.93 203 149269 33328 64315932
Posture abnormal 69.60 14.93 60 149412 3346 64345914
Neutrophil count abnormal 69.53 14.93 56 149416 2840 64346420
Impaired self-care 69.26 14.93 51 149421 2262 64346998
Visual impairment 69.20 14.93 43 149429 74034 64275226
Rebound psychosis 68.89 14.93 22 149450 133 64349127
Waxy flexibility 68.28 14.93 25 149447 240 64349020
Tobacco interaction 67.98 14.93 18 149454 48 64349212
Swelling face 67.92 14.93 26 149446 59140 64290120
Loss of personal independence in daily activities 67.76 14.93 42 149430 72412 64276848
Troponin I increased 67.53 14.93 62 149410 3759 64345501
Red blood cell count increased 67.38 14.93 60 149412 3495 64345765
Irritable bowel syndrome 67.36 14.93 5 149467 37364 64311896
Lactic acidosis 67.23 14.93 29 149443 61381 64287879
Suspiciousness 67.08 14.93 31 149441 560 64348700
Haematoma 66.79 14.93 13 149459 46237 64303023
Thinking abnormal 66.63 14.93 106 149366 11450 64337810
Cerebral haemorrhage 66.53 14.93 18 149454 51072 64298188
Vomiting 66.23 14.93 890 148582 550227 63799033
Therapy cessation 64.96 14.93 194 149278 32295 64316965
Rectal haemorrhage 64.85 14.93 31 149441 61786 64287474
Overweight 64.47 14.93 57 149415 3289 64345971
Blood pressure increased 64.26 14.93 196 149276 172356 64176904
Cytomegalovirus infection 64.24 14.93 6 149466 37193 64312067
Colitis ischaemic 63.95 14.93 113 149359 13301 64335959
Basophil count increased 63.89 14.93 39 149433 1261 64347999
Cardiac failure congestive 63.72 14.93 129 149343 130451 64218809
Delusion of grandeur 63.54 14.93 30 149442 570 64348690
Intestinal dilatation 63.51 14.93 48 149424 2216 64347044
Coma scale abnormal 63.35 14.93 84 149388 7690 64341570
Angioedema 63.34 14.93 32 149440 61789 64287471
Rhinorrhoea 63.02 14.93 30 149442 59939 64289321
Dry skin 63.00 14.93 20 149452 51141 64298119
Acute psychosis 62.68 14.93 59 149413 3693 64345567
Rash maculo-papular 62.31 14.93 16 149456 47010 64302250
Ascites 62.18 14.93 33 149439 61968 64287292
Dysphemia 61.83 14.93 54 149418 3065 64346195
Myocardial fibrosis 61.71 14.93 41 149431 1539 64347721
Mutism 61.25 14.93 45 149427 1989 64347271
Pseudophaeochromocytoma 61.12 14.93 18 149454 79 64349181
Haematuria 60.92 14.93 32 149440 60439 64288821
Eye pain 60.72 14.93 3 149469 31622 64317638
Pulmonary valve incompetence 60.64 14.93 41 149431 1585 64347675
Drug reaction with eosinophilia and systemic symptoms 60.31 14.93 25 149447 54192 64295068
Tinnitus 60.31 14.93 5 149467 34128 64315132
Burning sensation 60.12 14.93 20 149452 49644 64299616
Social avoidant behaviour 60.09 14.93 63 149409 4494 64344766
Throat irritation 60.06 14.93 4 149468 32707 64316553
Dehydration 60.03 14.93 278 149194 216485 64132775
Diverticulitis 59.84 14.93 9 149463 38609 64310651
Hypocalcaemia 59.74 14.93 12 149460 41741 64307519
Echocardiogram abnormal 59.40 14.93 42 149430 1747 64347513
Arteriosclerosis coronary artery 59.33 14.93 119 149353 15410 64333850
Vision blurred 58.43 14.93 74 149398 90242 64259018
Osteoporosis 58.35 14.93 13 149459 42067 64307193
Cataract 58.06 14.93 23 149449 51239 64298021
Skin lesion 57.70 14.93 8 149464 36474 64312786
Insomnia 57.62 14.93 249 149223 197587 64151673
Monocytosis 57.45 14.93 29 149443 641 64348619
Folliculitis 57.28 14.93 3 149469 30074 64319186
Hot flush 57.07 14.93 18 149454 46217 64303043
Feeling abnormal 57.02 14.93 142 149330 133460 64215800
Apathy 56.65 14.93 97 149375 11135 64338125
Musculoskeletal stiffness 56.54 14.93 126 149346 123080 64226180
Rash erythematous 56.45 14.93 21 149451 48612 64300648
Skin ulcer 56.31 14.93 16 149456 43958 64305302
Diabetes mellitus 56.09 14.93 303 149169 66171 64283089
Basal cell carcinoma 55.95 14.93 4 149468 30834 64318426
Lymphoma 55.88 14.93 109 149363 13832 64335428
Heart rate decreased 55.68 14.93 29 149443 55038 64294222
Dysarthria 55.10 14.93 278 149194 59128 64290132
Body mass index increased 54.60 14.93 38 149434 1541 64347719
Electrocardiogram T wave abnormal 54.59 14.93 52 149420 3304 64345956
Swollen tongue 54.50 14.93 8 149464 34946 64314314
Hyperkinesia 54.37 14.93 46 149426 2500 64346760
Imprisonment 54.23 14.93 26 149446 512 64348748
Obsessive-compulsive symptom 54.12 14.93 18 149454 126 64349134
Hyponatraemia 53.46 14.93 171 149301 148168 64201092
Exposure during pregnancy 53.05 14.93 61 149411 77614 64271646
Hypomagnesaemia 52.94 14.93 11 149461 37365 64311895
Haemoptysis 52.37 14.93 24 149448 49024 64300236
Mania 52.01 14.93 116 149356 16170 64333090
Gastrointestinal necrosis 51.99 14.93 61 149411 4931 64344329
Renal impairment 51.97 14.93 151 149321 134866 64214394
Lymphocyte percentage increased 51.62 14.93 26 149446 572 64348688
Polydipsia psychogenic 51.29 14.93 19 149453 189 64349071
Skin exfoliation 51.07 14.93 20 149452 44865 64304395
Cholestasis 51.04 14.93 20 149452 44852 64304408
Depression 50.78 14.93 235 149237 183056 64166204
Neutrophil count normal 50.70 14.93 10 149462 0 64349260
Akinesia 50.64 14.93 48 149424 3031 64346229
Subileus 50.49 14.93 60 149412 4917 64344343
Malaise 50.48 14.93 1238 148234 395009 63954251
Nephrolithiasis 50.47 14.93 19 149453 43664 64305596
Intentional self-injury 50.29 14.93 165 149307 28879 64320381
Melaena 50.13 14.93 31 149441 53517 64295743
Malignant catatonia 49.85 14.93 22 149450 355 64348905
Pancytopenia 49.03 14.93 169 149303 143140 64206120
Negativism 48.47 14.93 27 149445 733 64348527
Bundle branch block right 48.30 14.93 86 149386 10183 64339077
Lip swelling 48.17 14.93 8 149464 31899 64317361
Fibroma 48.14 14.93 26 149446 663 64348597
Electrocardiogram T wave inversion 48.00 14.93 58 149414 4836 64344424
Restlessness 47.89 14.93 201 149271 39584 64309676
Medication error 47.88 14.93 236 149236 49730 64299530
Mean cell haemoglobin concentration increased 47.59 14.93 27 149445 760 64348500
Haemorrhage 47.30 14.93 69 149403 79282 64269978
Haematocrit increased 47.27 14.93 48 149424 3297 64345963
Cerebral infarction 47.17 14.93 18 149454 41026 64308234
Hypervolaemia 47.08 14.93 15 149457 38270 64310990
Hypertension 46.90 14.93 380 149092 258881 64090379
Globulins decreased 46.81 14.93 21 149451 353 64348907
Hepatic failure 46.63 14.93 36 149436 55358 64293902
Thrombocytopenia 46.58 14.93 753 148719 223048 64126212
Knee arthroplasty 44.95 14.93 5 149467 26994 64322266
Skin discolouration 44.82 14.93 13 149459 35242 64314018
Cellulitis 44.44 14.93 94 149378 93563 64255697
Dry eye 44.42 14.93 7 149465 29012 64320248
Withdrawal catatonia 44.32 14.93 16 149456 147 64349113
Therapeutic product effect variable 44.23 14.93 34 149438 1610 64347650
Gastrointestinal carcinoma 44.23 14.93 37 149435 1980 64347280
Stoma site inflammation 43.89 14.93 23 149449 551 64348709
Cystitis 43.85 14.93 22 149450 42653 64306607
Hepatotoxicity 43.53 14.93 19 149453 39943 64309317
Pneumonitis 43.33 14.93 32 149440 50333 64298927
Nervousness 43.33 14.93 8 149464 29548 64319712
Gastrooesophageal reflux disease 43.29 14.93 79 149393 83064 64266196
Clostridium difficile infection 43.02 14.93 15 149457 36148 64313112
Osteonecrosis 42.79 14.93 7 149465 28222 64321038
Hepatitis C virus test positive 42.53 14.93 19 149453 316 64348944
C-reactive protein abnormal 42.29 14.93 8 149464 29039 64320221
Acne 41.86 14.93 3 149469 23078 64326182
Ejection fraction decreased 41.81 14.93 154 149318 28553 64320707
Toxic epidermal necrolysis 41.56 14.93 17 149455 37149 64312111
Posterior reversible encephalopathy syndrome 41.56 14.93 3 149469 22943 64326317
Polydipsia 41.56 14.93 59 149413 5762 64343498
Device related infection 41.39 14.93 10 149462 30616 64318644
Productive cough 41.37 14.93 66 149406 73137 64276123
Oral pain 41.27 14.93 7 149465 27486 64321774
Haemorrhoids 41.10 14.93 4 149468 23997 64325263
Haemorrhage intracranial 40.85 14.93 4 149468 23880 64325380
Gamma-glutamyltransferase increased 40.84 14.93 221 149251 48289 64300971
Neuralgia 40.81 14.93 6 149466 26178 64323082
Neoplasm progression 40.78 14.93 22 149450 40942 64308318
Hallucination, visual 40.27 14.93 149 149323 27685 64321575
Wrong technique in product usage process 40.21 14.93 55 149417 64919 64284341
Anion gap increased 39.99 14.93 42 149430 3002 64346258
Oral herpes 39.82 14.93 3 149469 22149 64327111
Angina pectoris 39.62 14.93 28 149444 45053 64304207
Fungal infection 39.40 14.93 15 149457 34236 64315024
Blood pressure systolic increased 39.31 14.93 34 149438 49419 64299841
Feeling hot 39.30 14.93 29 149443 45634 64303626
Candida infection 39.19 14.93 12 149460 31407 64317853
Joint stiffness 39.04 14.93 11 149461 30393 64318867
QRS axis abnormal 39.00 14.93 33 149439 1794 64347466
Oxygen saturation decreased 38.99 14.93 123 149349 107053 64242207
Polyserositis 38.82 14.93 20 149452 462 64348798
Delusional disorder, unspecified type 38.63 14.93 23 149449 710 64348550
Pancreatic fibrosis 38.49 14.93 13 149459 96 64349164
Visual acuity reduced 38.41 14.93 8 149464 27133 64322127
Upper respiratory tract infection 38.03 14.93 69 149403 72716 64276544
Dysphonia 37.96 14.93 31 149441 46351 64302909
Coronavirus infection 37.94 14.93 55 149417 5475 64343785
Suicidal ideation 37.76 14.93 274 149198 66268 64282992
Tooth disorder 37.67 14.93 4 149468 22398 64326862
Diplopia 37.65 14.93 8 149464 26757 64322503
Psychomotor hyperactivity 37.55 14.93 95 149377 14356 64334904
Lymphadenopathy 37.23 14.93 32 149440 46654 64302606
Catecholamines urine increased 37.22 14.93 9 149463 14 64349246
Chronic obstructive pulmonary disease 37.18 14.93 287 149185 70761 64278499
Stupor 37.08 14.93 57 149415 5978 64343282
Asthma 37.00 14.93 106 149366 95119 64254141
Muscle injury 36.99 14.93 8 149464 26429 64322831
Disinhibition 36.95 14.93 35 149437 2208 64347052
Palpitations 36.56 14.93 122 149350 104366 64244894
Coronary artery disease 36.56 14.93 52 149420 60381 64288879
Mean cell haemoglobin increased 36.51 14.93 41 149431 3161 64346099
Stoma site irritation 36.44 14.93 15 149457 202 64349058
Obsessive thoughts 36.40 14.93 25 149447 992 64348268
Ventricular tachycardia 36.22 14.93 17 149455 34248 64315012
Mobility decreased 36.02 14.93 92 149380 85748 64263512
COVID-19 35.69 14.93 266 149206 64874 64284386
Blood disorder 35.61 14.93 60 149412 6797 64342463
Tricuspid valve incompetence 35.39 14.93 103 149369 16900 64332360
Rebound effect 35.34 14.93 50 149422 4867 64344393
Oesophageal carcinoma 35.24 14.93 49 149423 4694 64344566
Drug eruption 35.12 14.93 20 149452 36116 64313144
Coagulopathy 35.05 14.93 15 149457 31905 64317355
Device expulsion 34.97 14.93 4 149468 21132 64328128
Cervix neoplasm 34.87 14.93 14 149458 176 64349084
Echolalia 34.77 14.93 17 149455 350 64348910
Central obesity 34.64 14.93 28 149444 1427 64347833
Spleen congestion 34.62 14.93 18 149454 424 64348836
Throat tightness 34.53 14.93 6 149466 23154 64326106
Seminoma 34.52 14.93 14 149458 181 64349079
Dementia 34.20 14.93 116 149356 20650 64328610
Ventricular hypokinesia 33.92 14.93 63 149409 7706 64341554
Pneumocystis jirovecii pneumonia 33.67 14.93 11 149461 27623 64321637
Dry mouth 33.65 14.93 55 149417 60363 64288897
Gastric ulcer 33.53 14.93 14 149458 30220 64319040
Ocular hyperaemia 33.31 14.93 6 149466 22558 64326702
Liver function test increased 33.30 14.93 15 149457 30955 64318305
Inappropriate affect 33.27 14.93 26 149446 1262 64347998
Eosinophilic colitis 33.26 14.93 17 149455 386 64348874
Jaundice 33.22 14.93 38 149434 48474 64300786
Hepatic steatosis 33.01 14.93 151 149321 30856 64318404
Postmortem blood drug level increased 32.79 14.93 21 149451 740 64348520
Hyperbilirubinaemia 32.72 14.93 5 149467 21200 64328060
Hypercalcaemia 32.57 14.93 16 149456 31400 64317860
Drug level changed 32.57 14.93 18 149454 481 64348779
Neutrophil count 32.56 14.93 13 149459 161 64349099
Red cell distribution width decreased 32.50 14.93 24 149448 1069 64348191
Blunted affect 32.30 14.93 17 149455 411 64348849
Parkinsonism hyperpyrexia syndrome 32.29 14.93 14 149458 216 64349044
Impulsive behaviour 31.91 14.93 35 149437 2628 64346632
Electroconvulsive therapy 31.91 14.93 11 149461 87 64349173
Condition aggravated 31.86 14.93 640 148832 371786 63977474
Blood lactate dehydrogenase decreased 31.77 14.93 15 149457 285 64348975
Product quality issue 31.16 14.93 15 149457 29784 64319476
Confusional state 31.15 14.93 809 148663 260335 64088925
Stoma site reaction 31.12 14.93 15 149457 299 64348961
Drug-induced liver injury 30.84 14.93 39 149433 47604 64301656
Deep vein thrombosis 30.83 14.93 132 149340 105050 64244210
Affective disorder 30.81 14.93 55 149417 6525 64342735
Ill-defined disorder 30.72 14.93 34 149438 44018 64305242
Blood creatinine decreased 30.57 14.93 57 149415 6993 64342267
Foreign body ingestion 30.42 14.93 6 149466 0 64349260
Pulmonary hypertension 30.41 14.93 33 149439 43106 64306154
Localised infection 30.32 14.93 16 149456 30145 64319115
Cardiac steatosis 30.29 14.93 9 149463 41 64349219
Joint injury 30.03 14.93 8 149464 22939 64326321
Ideas of reference 30.02 14.93 12 149460 149 64349111
B-cell lymphoma 30.02 14.93 49 149423 5408 64343852
Vertigo 29.89 14.93 57 149415 58954 64290306
Ischaemic stroke 29.78 14.93 15 149457 29020 64320240
Delusional disorder, persecutory type 29.56 14.93 16 149456 410 64348850
Faecal vomiting 29.35 14.93 22 149450 1003 64348257
Injection site mass 29.25 14.93 3 149469 17267 64331993
Hypersplenism 29.17 14.93 16 149456 421 64348839
Encephalitis toxic 29.14 14.93 14 149458 277 64348983
Lymphocytosis 29.12 14.93 39 149433 3605 64345655
Intestinal ischaemia 29.05 14.93 75 149397 11474 64337786
Musculoskeletal chest pain 29.05 14.93 7 149465 21472 64327788
Femur fracture 28.96 14.93 22 149450 34113 64315147
Visceral congestion 28.93 14.93 20 149452 802 64348458
Monocyte percentage increased 28.81 14.93 29 149443 1971 64347289
Photosensitivity reaction 28.70 14.93 4 149468 18169 64331091
Metamyelocyte count increased 28.70 14.93 18 149454 611 64348649
Disseminated intravascular coagulation 28.55 14.93 20 149452 32328 64316932
Schizoaffective disorder bipolar type 28.47 14.93 11 149461 124 64349136
Transfusion 28.33 14.93 4 149468 17990 64331270
Acute myocardial infarction 28.27 14.93 76 149396 69642 64279618
Blood osmolarity increased 28.23 14.93 17 149455 536 64348724
Shock haemorrhagic 28.23 14.93 3 149469 16788 64332472
Blindness 28.21 14.93 8 149464 22011 64327249
Abdominal pain lower 28.18 14.93 13 149459 26456 64322804
High density lipoprotein decreased 28.18 14.93 40 149432 3906 64345354
Bone disorder 28.16 14.93 3 149469 16756 64332504
Musculoskeletal disorder 28.14 14.93 4 149468 17902 64331358
Heart rate increased 28.12 14.93 351 149121 98324 64250936
Clostridium difficile colitis 28.02 14.93 14 149458 27209 64322051
Cardiomegaly 27.99 14.93 119 149353 23565 64325695
Type 2 diabetes mellitus 27.97 14.93 154 149318 33866 64315394
Testicular germ cell cancer metastatic 27.96 14.93 9 149463 56 64349204
Limb discomfort 27.93 14.93 14 149458 27161 64322099
Incontinence 27.90 14.93 76 149396 12005 64337255
Electrocardiogram T wave amplitude decreased 27.89 14.93 17 149455 548 64348712
Flatulence 27.77 14.93 25 149447 35641 64313619
Drug level above therapeutic 27.71 14.93 54 149418 6847 64342413
Thought blocking 27.63 14.93 12 149460 186 64349074
Injury 27.57 14.93 55 149417 55937 64293323
Left atrial dilatation 27.49 14.93 33 149439 2733 64346527
Anaemia 27.44 14.93 668 148804 378012 63971248
Patient restraint 27.40 14.93 10 149462 95 64349165
Neutrophil percentage increased 27.33 14.93 42 149430 4403 64344857
Bone marrow failure 27.32 14.93 43 149429 47909 64301351
Ear pain 27.30 14.93 12 149460 25124 64324136
Dilatation ventricular 27.30 14.93 39 149433 3831 64345429
Glaucoma 27.28 14.93 3 149469 16345 64332915
Aortic dilatation 27.23 14.93 24 149448 1379 64347881
Osteomyelitis 27.19 14.93 15 149457 27572 64321688
Gastric disorder 27.19 14.93 17 149455 29180 64320080
Hypoacusis 27.08 14.93 13 149459 25854 64323406
Gout 27.03 14.93 8 149464 21405 64327855
Pulmonary fibrosis 27.00 14.93 18 149454 29860 64319400
Influenza 26.94 14.93 141 149331 106390 64242870
Torticollis 26.77 14.93 29 149443 2148 64347112
Dysuria 26.63 14.93 35 149437 42022 64307238
Unresponsive to stimuli 26.60 14.93 204 149268 50189 64299071
Abnormal clotting factor 26.43 14.93 10 149462 106 64349154
Haemodialysis 26.41 14.93 4 149468 17073 64332187
Brain injury 26.41 14.93 66 149406 9899 64339361
Blood pressure fluctuation 26.36 14.93 50 149422 51821 64297439
Suicidal behaviour 26.36 14.93 33 149439 2854 64346406
Excessive masturbation 26.35 14.93 9 149463 69 64349191
SARS-CoV-2 test positive 26.23 14.93 50 149422 6236 64343024
Neutrophil percentage decreased 26.12 14.93 18 149454 718 64348542
Blood osmolarity decreased 26.00 14.93 22 149450 1196 64348064
Chronic hepatitis C 25.94 14.93 16 149456 527 64348733
Limb injury 25.88 14.93 11 149461 23494 64325766
Eosinopenia 25.84 14.93 8 149464 43 64349217
Behaviour disorder 25.82 14.93 41 149431 4421 64344839
Eye disorder 25.82 14.93 6 149466 18863 64330397
Myelocyte count increased 25.77 14.93 18 149454 734 64348526
High-grade B-cell lymphoma 25.59 14.93 9 149463 76 64349184
Depressed level of consciousness 25.54 14.93 295 149177 81141 64268119
Withdrawal syndrome 25.45 14.93 115 149357 23377 64325883
Incoherent 25.36 14.93 53 149419 7065 64342195
Non-Hodgkin's lymphoma unspecified histology aggressive 25.35 14.93 5 149467 0 64349260
Obstructive airways disorder 25.29 14.93 11 149461 23174 64326086
Drug level fluctuating 25.26 14.93 17 149455 652 64348608
Self-injurious ideation 25.22 14.93 34 149438 3163 64346097
Hip arthroplasty 25.15 14.93 9 149463 21342 64327918
Blood urea nitrogen/creatinine ratio decreased 25.09 14.93 9 149463 81 64349179
Colitis ulcerative 25 14.93 11 149461 23017 64326243
Blood alkaline phosphatase increased 24.95 14.93 219 149253 56060 64293200
Drug dose titration not performed 24.94 14.93 17 149455 666 64348594
Ulcer 24.93 14.93 11 149461 22979 64326281
Myelosuppression 24.91 14.93 12 149460 23818 64325442
Lacrimation increased 24.77 14.93 6 149466 18340 64330920
Protein total decreased 24.75 14.93 56 149416 7880 64341380
Musculoskeletal discomfort 24.75 14.93 4 149468 16273 64332987
Frequent bowel movements 24.69 14.93 6 149466 18299 64330961
Bacteraemia 24.61 14.93 16 149456 26895 64322365
Purpura 24.58 14.93 5 149467 17241 64332019
Myelodysplastic syndrome 24.41 14.93 17 149455 27562 64321698
Blood bilirubin decreased 24.39 14.93 18 149454 801 64348459
Intentional overdose 24.38 14.93 317 149155 89627 64259633
Testicular cancer metastatic 24.30 14.93 8 149464 54 64349206
Judgement impaired 24.18 14.93 20 149452 1053 64348207
Testicular atrophy 24.16 14.93 13 149459 329 64348931
Reduced facial expression 24.00 14.93 27 149445 2086 64347174
Eosinophilic myocarditis 23.76 14.93 18 149454 834 64348426
Tangentiality 23.75 14.93 10 149462 143 64349117
Product prescribing error 23.75 14.93 28 149444 35241 64314019
Sudden cardiac death 23.64 14.93 40 149432 4547 64344713
Red blood cell elliptocytes present 23.56 14.93 10 149462 146 64349114
Anisocytosis 23.55 14.93 18 149454 845 64348415
Intentional product misuse 23.55 14.93 87 149385 72208 64277052
Presyncope 23.47 14.93 28 149444 35061 64314199
Blood creatine phosphokinase decreased 23.36 14.93 17 149455 740 64348520
Granulocytosis 23.30 14.93 12 149460 277 64348983
Skin disorder 23.28 14.93 18 149454 27662 64321598
Blood creatinine increased 23.17 14.93 202 149270 135580 64213680
Procedural pain 23.16 14.93 4 149468 15504 64333756
Spinal osteoarthritis 23.02 14.93 3 149469 14338 64334922
Drug dependence 22.91 14.93 26 149446 33286 64315974
Therapeutic product effect incomplete 22.91 14.93 143 149329 103339 64245921
Volvulus 22.90 14.93 27 149445 2194 64347066
Thrombocytosis 22.88 14.93 51 149421 7105 64342155
Loss of consciousness 22.72 14.93 476 148996 147889 64201371
Photophobia 22.69 14.93 6 149466 17287 64331973
Parkinson's disease 22.67 14.93 23 149449 1578 64347682
Disturbance in attention 22.65 14.93 168 149304 40906 64308354
Cardiac disorder 22.61 14.93 213 149259 55603 64293657
Impaired work ability 22.57 14.93 4 149468 15215 64334045
Flank pain 22.44 14.93 5 149467 16184 64333076
Ecchymosis 22.35 14.93 3 149469 14019 64335241
Face oedema 22.26 14.93 15 149457 24746 64324514
Systolic dysfunction 22.19 14.93 32 149440 3170 64346090
Right ventricular failure 22.16 14.93 11 149461 21460 64327800
Blood bicarbonate decreased 22.15 14.93 40 149432 4789 64344471
Nodule 22.12 14.93 7 149465 17940 64331320
Diet refusal 21.91 14.93 17 149455 816 64348444
Somatic dysfunction 21.90 14.93 6 149466 19 64349241
Sedation complication 21.81 14.93 63 149409 10291 64338969
Night sweats 21.81 14.93 31 149441 36015 64313245
Rash macular 21.77 14.93 14 149458 23671 64325589
Amnesia 21.61 14.93 50 149422 48219 64301041
Upper gastrointestinal haemorrhage 21.60 14.93 30 149442 35190 64314070
Neurotoxicity 21.59 14.93 19 149453 27385 64321875
Flat affect 21.55 14.93 24 149448 1833 64347427
Cervix cancer metastatic 21.42 14.93 5 149467 6 64349254
Globulin abnormal 21.42 14.93 5 149467 6 64349254
Poor personal hygiene 21.42 14.93 14 149458 511 64348749
Hypophagia 21.31 14.93 161 149311 39426 64309834
Nephropathy toxic 21.29 14.93 7 149465 17507 64331753
Drowning 21.28 14.93 16 149456 733 64348527
Hyperosmolar state 21.13 14.93 15 149457 628 64348632
Pharyngeal oedema 21.13 14.93 5 149467 15526 64333734
Gender dysphoria 21.05 14.93 7 149465 49 64349211
Liver disorder 21.00 14.93 59 149413 53292 64295968
Intestinal infarction 20.99 14.93 20 149452 1271 64347989
Drop attacks 20.98 14.93 18 149454 997 64348263
Learning disability 20.85 14.93 10 149462 197 64349063
Influenza B virus test positive 20.80 14.93 12 149460 349 64348911
Tobacco user 20.80 14.93 15 149457 644 64348616
Memory impairment 20.78 14.93 115 149357 85567 64263693
Eye swelling 20.71 14.93 13 149459 22268 64326992
Cardiac arrest 20.65 14.93 485 148987 153579 64195681
Chest pain 20.61 14.93 404 149068 235576 64113684
Cogwheel rigidity 20.49 14.93 29 149443 2824 64346436
Tension 20.48 14.93 34 149438 3806 64345454
Dermatitis allergic 20.29 14.93 5 149467 15104 64334156
Investigation noncompliance 20.28 14.93 4 149468 0 64349260
Electrocardiogram ST segment elevation 20.21 14.93 49 149423 7210 64342050
Balance disorder 20.16 14.93 113 149359 83813 64265447
Stoma site extravasation 20.11 14.93 11 149461 288 64348972
Oropharyngeal pain 20.09 14.93 122 149350 88745 64260515
Total cholesterol/HDL ratio increased 20.06 14.93 10 149462 215 64349045
Petechiae 20.06 14.93 9 149463 18617 64330643
Blood sodium increased 20.05 14.93 36 149436 4290 64344970
Necrotising colitis 20.05 14.93 17 149455 927 64348333
Premature delivery 19.99 14.93 9 149463 18580 64330680
Staphylococcal infection 19.98 14.93 56 149416 50622 64298638
Chromaturia 19.93 14.93 14 149458 22597 64326663
Stoma site discomfort 19.83 14.93 8 149464 102 64349158
Gingival bleeding 19.78 14.93 5 149467 14849 64334411
Acute coronary syndrome 19.77 14.93 10 149462 19300 64329960
Radiation inflammation 19.77 14.93 10 149462 222 64349038
Rib fracture 19.75 14.93 16 149456 24022 64325238
Amylase decreased 19.71 14.93 9 149463 158 64349102
Gait inability 19.69 14.93 43 149429 42325 64306935
Priapism 19.65 14.93 34 149438 3936 64345324
Loss of libido 19.63 14.93 26 149446 2378 64346882
Product use issue 19.61 14.93 241 149231 151474 64197786
Drug level decreased 19.60 14.93 65 149407 11438 64337822
Deafness 19.57 14.93 9 149463 18350 64330910
Blood urine present 19.54 14.93 9 149463 18331 64330929
Ventricular fibrillation 19.46 14.93 16 149456 23844 64325416
Spinal pain 19.42 14.93 3 149469 12618 64336642
Polyneuropathy 19.34 14.93 11 149461 19883 64329377
Blood albumin decreased 19.10 14.93 98 149374 20975 64328285
Water intoxication 19.07 14.93 15 149457 735 64348525
Syncope 19.05 14.93 254 149218 157381 64191879
Posturing 19.02 14.93 17 149455 995 64348265
Serositis 18.96 14.93 15 149457 741 64348519
Creatinine renal clearance decreased 18.92 14.93 5 149467 14416 64334844
Euphoric mood 18.90 14.93 45 149427 6546 64342714
Hypersensitivity myocarditis 18.86 14.93 7 149465 70 64349190
Skin reaction 18.86 14.93 3 149469 12349 64336911
Skin necrosis 18.74 14.93 5 149467 14324 64334936
Microcytosis 18.73 14.93 11 149461 331 64348929
Drug-disease interaction 18.70 14.93 15 149457 756 64348504
Proteinuria 18.68 14.93 22 149450 27701 64321559
Hepatic function abnormal 18.67 14.93 81 149391 64232 64285028
Mitral valve incompetence 18.63 14.93 112 149360 25426 64323834
Blood pressure decreased 18.63 14.93 120 149352 86079 64263181
Delusional perception 18.61 14.93 11 149461 335 64348925
Viral myocarditis 18.61 14.93 12 149460 428 64348832
Norepinephrine increased 18.60 14.93 7 149465 73 64349187
Full blood count decreased 18.59 14.93 15 149457 22567 64326693
Glucose tolerance impaired 18.49 14.93 44 149428 6399 64342861
Blood cholesterol decreased 18.45 14.93 20 149452 1482 64347778
Atonic seizures 18.43 14.93 14 149458 651 64348609
Hypoxia 18.40 14.93 124 149348 88025 64261235
Life support 18.38 14.93 12 149460 437 64348823
Complication associated with device 18.38 14.93 6 149466 15074 64334186
Blood bilirubin increased 18.26 14.93 70 149402 57483 64291777
Device malfunction 18.25 14.93 9 149463 17624 64331636
Myocardial necrosis marker increased 18.17 14.93 27 149445 2748 64346512
Grandiosity 18.15 14.93 13 149459 552 64348708
Gait disturbance 18.14 14.93 285 149187 171870 64177390
Subdural haematoma 18.12 14.93 23 149449 28031 64321229
Drug titration error 18.08 14.93 16 149456 924 64348336
Muscle spasticity 18.04 14.93 8 149464 16661 64332599
Transient ischaemic attack 18.04 14.93 48 149424 44134 64305126
Paraneoplastic rash 18.03 14.93 7 149465 80 64349180
Electrocardiogram ST-T change 17.94 14.93 20 149452 1529 64347731
Poverty of speech 17.86 14.93 13 149459 566 64348694
Haematotoxicity 17.84 14.93 4 149468 12892 64336368
Eye movement disorder 17.84 14.93 46 149426 7033 64342227
Enterococcal infection 17.83 14.93 5 149467 13861 64335399
Blood phosphorus increased 17.82 14.93 37 149435 4909 64344351
Compensatory sweating 17.68 14.93 6 149466 45 64349215
Pericarditis 17.65 14.93 222 149250 62294 64286966
Cerebrovascular accident 17.61 14.93 219 149253 137364 64211896
Lung disorder 17.28 14.93 77 149395 60623 64288637
Nightmare 17.22 14.93 14 149458 20979 64328281
Oral candidiasis 17.21 14.93 17 149455 23195 64326065
Retrograde ejaculation 17.20 14.93 9 149463 215 64349045
Lymphocyte morphology abnormal 17.09 14.93 15 149457 857 64348403
Adjusted calcium increased 17.03 14.93 6 149466 51 64349209
Carditis 17.02 14.93 7 149465 94 64349166
Cognitive disorder 17.02 14.93 199 149273 54888 64294372
Pregnancy 17.01 14.93 14 149458 20851 64328409
Tonic clonic movements 17.00 14.93 22 149450 1967 64347293
Crying 16.98 14.93 13 149459 20077 64329183
Hypersexuality 16.97 14.93 19 149453 1460 64347800
Cardiac septal hypertrophy 16.90 14.93 9 149463 223 64349037
Abortion spontaneous 16.89 14.93 20 149452 25123 64324137
Gastritis 16.87 14.93 47 149425 42571 64306689
Left atrial enlargement 16.80 14.93 16 149456 1016 64348244
Conduction disorder 16.80 14.93 27 149445 2941 64346319
Stoma site oedema 16.79 14.93 5 149467 23 64349237
Alcohol problem 16.73 14.93 6 149466 54 64349206
Laryngeal cancer stage III 16.61 14.93 5 149467 24 64349236
Lethargy 16.50 14.93 248 149224 72346 64276914
Type 1 diabetes mellitus 16.41 14.93 39 149433 5666 64343594
Disability 16.40 14.93 4 149468 12168 64337092
Repetitive speech 16.39 14.93 10 149462 323 64348937
Pulmonary haemorrhage 16.36 14.93 5 149467 13104 64336156
Blood folate decreased 16.35 14.93 16 149456 1051 64348209
Bladder trabeculation 16.35 14.93 6 149466 58 64349202
Illness anxiety disorder 16.34 14.93 9 149463 239 64349021
Physical assault 16.28 14.93 19 149453 1527 64347733
Endotracheal intubation 16.28 14.93 31 149441 3864 64345396
Acute myeloid leukaemia 16.24 14.93 24 149448 27439 64321821
Left ventricular dilatation 16.23 14.93 15 149457 917 64348343
Dermatitis bullous 16.16 14.93 4 149468 12050 64337210
White blood cell disorder 16.12 14.93 25 149447 2642 64346618
Prescribed underdose 16.08 14.93 11 149461 18004 64331256
Disorientation 16.08 14.93 199 149273 55629 64293631
Foreign body 16.06 14.93 24 149448 2455 64346805
Compulsions 16.04 14.93 10 149462 336 64348924
Staphylococcal sepsis 15.95 14.93 5 149467 12894 64336366
Resting tremor 15.94 14.93 18 149454 1396 64347864
Gallbladder cholesterolosis 15.93 14.93 12 149460 551 64348709
Palliative care 15.91 14.93 13 149459 673 64348587
Sperm concentration decreased 15.83 14.93 6 149466 64 64349196
Sputum discoloured 15.81 14.93 11 149461 17845 64331415
Borderline personality disorder 15.80 14.93 14 149458 810 64348450
Blood pressure diastolic decreased 15.78 14.93 17 149455 22284 64326976
Vascular dementia 15.77 14.93 14 149458 812 64348448
Oliguria 15.76 14.93 7 149465 14569 64334691
Coma 15.74 14.93 288 149184 87327 64261933
Cardiac failure 15.73 14.93 214 149258 132159 64217101
Hemiplegia 15.70 14.93 5 149467 12763 64336497
Myoclonic epilepsy 15.68 14.93 19 149453 1589 64347671
Crush syndrome 15.64 14.93 8 149464 182 64349078
Mean platelet volume increased 15.61 14.93 15 149457 963 64348297
Sexually inappropriate behaviour 15.57 14.93 11 149461 457 64348803
Dementia with Lewy bodies 15.57 14.93 13 149459 694 64348566
Eosinophilic pleural effusion 15.53 14.93 9 149463 264 64348996
Cholinergic syndrome 15.53 14.93 14 149458 829 64348431
Cardiopulmonary failure 15.45 14.93 40 149432 6130 64343130
Thyroid disorder 15.45 14.93 4 149468 11688 64337572
Soliloquy 15.43 14.93 12 149460 578 64348682
Feminisation acquired 15.42 14.93 5 149467 32 64349228
Toxic dilatation of intestine 15.21 14.93 3 149469 0 64349260
Haemorrhoid infection 15.21 14.93 3 149469 0 64349260
Blood folate abnormal 15.21 14.93 3 149469 0 64349260
Phobic avoidance 15.21 14.93 3 149469 0 64349260
Red blood cell burr cells present 15.21 14.93 3 149469 0 64349260
Blood cannabinoids 15.21 14.93 3 149469 0 64349260
Electrocardiogram QT interval abnormal 15.05 14.93 9 149463 280 64348980
Bronchiectasis 14.97 14.93 7 149465 14133 64335127
Tenderness 14.95 14.93 14 149458 19588 64329672

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Extrapyramidal disorder 23.64 23.36 5 151 4 84518

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent
CHEBI has role CHEBI:65259 GABA antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
Histone H1.0 Nuclear other Ki 9 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Calmodulin-1 Cytosolic other IC50 4.70 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
Alpha-1B adrenergic receptor GPCR Ki 8.45 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Transporter Transporter Ki 6.41 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 5A GPCR ANTAGONIST Ki 5.30 IUPHAR
Calmodulin Cytosolic other Kd 4.21 CHEMBL

External reference:

IDSource
4019488 VUID
N0000147608 NUI
D00283 KEGG_DRUG
216102 RXNORM
4019488 VANDF
4024939 VANDF
4036908 VANDF
4037056 VANDF
4037345 VANDF
4040180 VANDF
C0009079 UMLSCUI
CHEBI:3766 CHEBI
CHEMBL42 ChEMBL_ID
CHEMBL538973 ChEMBL_ID
DB00363 DRUGBANK_ID
D003024 MESH_DESCRIPTOR_UI
135398737 PUBCHEM_CID
38 IUPHAR_LIGAND_ID
2612 INN_ID
J60AR2IKIC UNII
11496 MMSL
420 MMSL
4484 MMSL
50904 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
96221003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0825 TABLET 25 mg ORAL ANDA 26 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0825 TABLET 25 mg ORAL ANDA 26 sections