clozapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 3133.23 14.66 1661 71523 61724 46551154
Granulocytopenia 2902.66 14.66 807 72377 4466 46608412
Neutrophil count increased 2573.16 14.66 932 72252 13321 46599557
White blood cell count increased 2185.78 14.66 1160 72024 43059 46569819
Neutropenia 2123.82 14.66 1769 71415 141435 46471443
Schizophrenia 2111.90 14.66 707 72477 7861 46605017
Neutrophilia 1593.70 14.66 446 72738 2531 46610347
Antipsychotic drug level increased 1544.97 14.66 442 72742 2750 46610128
Death 1398.50 14.66 2134 71050 333414 46279464
Psychotic disorder 1022.68 14.66 560 72624 22061 46590817
Salivary hypersecretion 980.45 14.66 372 72812 6073 46606805
Neutrophil count decreased 851.02 14.66 634 72550 42792 46570086
White blood cell count decreased 825.32 14.66 946 72238 111285 46501593
Differential white blood cell count abnormal 805.54 14.66 191 72993 474 46612404
Agranulocytosis 792.46 14.66 471 72713 21714 46591164
Sedation 750.20 14.66 460 72724 22450 46590428
Mental impairment 694.93 14.66 355 72829 12101 46600777
Leukopenia 539.06 14.66 598 72586 67745 46545133
Platelet count increased 515.98 14.66 310 72874 14564 46598314
Myocarditis 485.86 14.66 239 72945 7500 46605378
Pain 422.01 14.66 114 73070 476834 46136044
Nausea 405.99 14.66 294 72890 687160 45925718
Neuroleptic malignant syndrome 383.64 14.66 231 72953 10891 46601987
Antipsychotic drug level above therapeutic 383.17 14.66 114 73070 827 46612051
Arthralgia 375.85 14.66 61 73123 364542 46248336
Headache 374.10 14.66 142 73042 478210 46134668
Rheumatoid arthritis 360.02 14.66 3 73181 240212 46372666
Hallucination, auditory 349.44 14.66 215 72969 10541 46602337
Rash 345.08 14.66 70 73114 356442 46256436
Anosognosia 334.26 14.66 113 73071 1292 46611586
Mental disorder 330.37 14.66 277 72907 22148 46590730
Fatigue 329.11 14.66 284 72900 608413 46004465
Treatment noncompliance 324.48 14.66 310 72874 29421 46583457
Tachycardia 317.56 14.66 564 72620 99058 46513820
Dystonia 305.87 14.66 201 72983 11056 46601822
Drug level increased 301.43 14.66 242 72942 18199 46594679
Disturbance in social behaviour 296.34 14.66 109 73075 1622 46611256
Electrocardiogram QT prolonged 294.12 14.66 382 72802 50943 46561935
Catatonia 293.67 14.66 135 73049 3627 46609251
Blood prolactin abnormal 292.26 14.66 100 73084 1189 46611689
Delusion 287.62 14.66 193 72991 10995 46601883
Pruritus 264.67 14.66 34 73150 242318 46370560
Drug hypersensitivity 261.99 14.66 36 73148 243789 46369089
C-reactive protein increased 257.76 14.66 384 72800 58206 46554672
Haemoglobin decreased 257.11 14.66 601 72583 128348 46484530
Diarrhoea 245.94 14.66 311 72873 559291 46053587
Sexual dysfunction 241.61 14.66 103 73081 2300 46610578
Metabolic disorder 237.52 14.66 123 73061 4309 46608569
Psychiatric decompensation 230.95 14.66 81 73103 1042 46611836
Leukocytosis 229.19 14.66 230 72954 23168 46589710
Schizoaffective disorder 228.67 14.66 86 73098 1366 46611512
Antipsychotic drug level decreased 227.18 14.66 53 73131 119 46612759
Pain in extremity 226 14.66 63 73121 258617 46354261
Dyskinesia 224.15 14.66 251 72933 28674 46584204
Suicide attempt 211.63 14.66 339 72845 54697 46558181
Pre-existing disease 207.07 14.66 49 73135 120 46612758
Lower respiratory tract infection 204.57 14.66 334 72850 54755 46558123
Alopecia 184.09 14.66 20 73164 162394 46450484
Eosinophil count decreased 182.39 14.66 74 73110 1452 46611426
Sinus tachycardia 181.83 14.66 196 72988 21453 46591425
Overdose 177.20 14.66 451 72733 101528 46511350
Antipsychotic drug level below therapeutic 174.83 14.66 48 73136 250 46612628
Peripheral swelling 170.46 14.66 23 73161 158048 46454830
Joint swelling 168.05 14.66 29 73155 166044 46446834
Eosinophil count increased 165.46 14.66 120 73064 7746 46605132
Personality change 165.43 14.66 103 73081 5155 46607723
Sinusitis 160.58 14.66 11 73173 129757 46483121
Back pain 159.27 14.66 65 73119 209974 46402904
Drug interaction 159.15 14.66 685 72499 202409 46410469
Paranoia 158.30 14.66 132 73052 10465 46602413
Somnolence 152.33 14.66 565 72619 155956 46456922
Dyspnoea 143.44 14.66 379 72805 515169 46097709
Extrapyramidal disorder 143.26 14.66 128 73056 11140 46601738
Urticaria 140.20 14.66 12 73172 117880 46494998
Abdominal discomfort 139.19 14.66 33 73151 151132 46461746
Agitation 136.01 14.66 281 72903 55134 46557744
Erythema 131.85 14.66 31 73153 142789 46470089
Troponin increased 130.73 14.66 104 73080 7712 46605166
Swelling 129.83 14.66 20 73164 124491 46488387
Aspiration 122.61 14.66 109 73075 9422 46603456
Hypersensitivity 121.46 14.66 42 73142 150279 46462599
Lung neoplasm malignant 120.97 14.66 135 73049 15354 46597524
Drug ineffective 120.56 14.66 601 72583 677237 45935641
Aggression 118.99 14.66 162 73022 22582 46590296
Monocyte count increased 117.45 14.66 82 73102 4982 46607896
Drug intolerance 115.55 14.66 43 73141 147006 46465872
Akathisia 115.03 14.66 96 73088 7618 46605260
Neoplasm malignant 113.40 14.66 161 73023 23338 46589540
Lymphocyte count decreased 112.85 14.66 168 73016 25421 46587457
Coronavirus infection 112.04 14.66 64 73120 2730 46610148
Psychotic symptom 111.75 14.66 45 73139 865 46612013
Living in residential institution 111.43 14.66 36 73148 353 46612525
Chronic obstructive pulmonary disease 110.72 14.66 265 72919 57368 46555510
General physical condition abnormal 110.70 14.66 69 73115 3459 46609419
Drooling 108.95 14.66 66 73118 3143 46609735
Obsessive-compulsive disorder 106.27 14.66 65 73119 3150 46609728
Hypoaesthesia 105.44 14.66 28 73156 118841 46494037
Mean cell haemoglobin decreased 104.33 14.66 62 73122 2850 46610028
Lymphocyte count increased 104.15 14.66 61 73123 2729 46610149
Refusal of examination 103.46 14.66 22 73162 25 46612853
Neuropathy peripheral 103.43 14.66 11 73173 90882 46521996
Nasopharyngitis 102.36 14.66 57 73127 153941 46458937
Psoriasis 102.29 14.66 5 73179 78599 46534279
Electroencephalogram abnormal 101.88 14.66 67 73117 3687 46609191
Intestinal obstruction 100.69 14.66 161 73023 25914 46586964
Off label use 100.37 14.66 286 72898 379555 46233323
Choking 98.34 14.66 91 73093 8285 46604593
Abnormal behaviour 98.27 14.66 142 73042 20916 46591962
Eosinophilia 97.69 14.66 135 73049 19082 46593796
Orthostatic hypotension 97.62 14.66 154 73030 24504 46588374
Abdominal pain upper 96.26 14.66 54 73130 145251 46467627
Asthenia 95.44 14.66 217 72967 310858 46302020
Pleurothotonus 94.67 14.66 43 73141 1122 46611756
Disease progression 94.40 14.66 15 73169 91285 46521593
Terminal state 94.08 14.66 53 73131 2201 46610677
Hyperprolactinaemia 93.66 14.66 58 73126 2874 46610004
Blood creatine phosphokinase increased 93.40 14.66 161 73023 27563 46585315
Mean cell volume decreased 92.81 14.66 54 73130 2386 46610492
Arthropathy 92.03 14.66 12 73172 84688 46528190
Muscle spasms 91.79 14.66 39 73145 123074 46489804
Breast cancer 90.35 14.66 212 72972 45306 46567572
Cough 89.64 14.66 139 73045 230110 46382768
Urinary incontinence 88.76 14.66 160 73024 28370 46584508
Treatment failure 88.30 14.66 19 73165 93068 46519810
Generalised tonic-clonic seizure 88.10 14.66 155 73029 26967 46585911
Delirium 88.07 14.66 186 72998 37042 46575836
Paraesthesia 87.87 14.66 37 73147 117400 46495478
Stomatitis 86.81 14.66 5 73179 68292 46544586
Psychiatric symptom 84.25 14.66 64 73120 4433 46608445
Myalgia 84.06 14.66 44 73140 123044 46489834
Pneumonia aspiration 83.15 14.66 165 73019 31440 46581438
Blood prolactin increased 82.08 14.66 54 73130 2973 46609905
Metabolic syndrome 81.60 14.66 40 73144 1244 46611634
Musculoskeletal pain 81.04 14.66 8 73176 70120 46542758
Myoclonus 80.85 14.66 106 73078 14246 46598632
Febrile neutropenia 80.73 14.66 24 73160 94603 46518275
Diabetes mellitus 80.28 14.66 215 72969 49850 46563028
Dementia 79.08 14.66 107 73077 14823 46598055
Malignant neoplasm progression 78.85 14.66 6 73178 64920 46547958
Enuresis 78.03 14.66 45 73139 1955 46610923
Decreased appetite 77.36 14.66 115 73069 193721 46419157
Neutrophil count abnormal 77.08 14.66 48 73136 2402 46610476
Muscle rigidity 76.38 14.66 86 73098 9875 46603003
Migraine 75.88 14.66 10 73174 70016 46542862
Flushing 75.64 14.66 7 73177 64607 46548271
Mean cell haemoglobin concentration decreased 75.49 14.66 48 73136 2492 46610386
Tardive dyskinesia 75.40 14.66 75 73109 7468 46605410
Acute kidney injury 75.17 14.66 161 73023 235694 46377184
Circulatory collapse 74.71 14.66 127 73057 21497 46591381
Troponin T increased 74.58 14.66 34 73150 895 46611983
Haemoglobin increased 73.55 14.66 48 73136 2607 46610271
Sopor 71.89 14.66 119 73065 19709 46593169
Intentional self-injury 70.72 14.66 132 73052 24034 46588844
Acute psychosis 70.29 14.66 42 73142 1950 46610928
Oedema peripheral 69.48 14.66 89 73095 159617 46453261
Hallucination 68.79 14.66 203 72981 49748 46563130
Electrocardiogram abnormal 68.77 14.66 69 73115 6943 46605935
Therapeutic product effect decreased 68.57 14.66 22 73162 82579 46530299
Anaphylactic reaction 67.16 14.66 4 73180 53108 46559770
Mutism 66.57 14.66 35 73149 1265 46611613
Faecaloma 66.51 14.66 71 73113 7681 46605197
Body temperature increased 65.64 14.66 130 73054 24731 46588147
Epistaxis 65.49 14.66 11 73173 64294 46548584
Arthritis 65.24 14.66 20 73164 77296 46535582
Dyspepsia 64.88 14.66 14 73170 68458 46544420
Systemic lupus erythematosus 64.53 14.66 12 73172 65168 46547710
Constipation 64.23 14.66 480 72704 173617 46439261
Pericardial effusion 63.19 14.66 130 73054 25413 46587465
Gastrointestinal hypomotility 63.09 14.66 32 73152 1072 46611806
Haematocrit decreased 62.84 14.66 157 73027 34900 46577978
Lung cancer metastatic 62.04 14.66 42 73142 2426 46610452
Mean cell volume increased 61.21 14.66 44 73140 2800 46610078
Schizoaffective disorder bipolar type 60.33 14.66 17 73167 99 46612779
Nasal congestion 59.71 14.66 4 73180 48109 46564769
Pneumonia 58.47 14.66 870 72314 375450 46237428
Herpes zoster 58.27 14.66 17 73167 67855 46545023
COVID-19 57.55 14.66 104 73080 18471 46594407
Wrong patient received product 57.11 14.66 35 73149 1702 46611176
Gastrointestinal carcinoma 57.08 14.66 31 73153 1197 46611681
Monocyte count decreased 56.74 14.66 35 73149 1722 46611156
Impaired self-care 56.54 14.66 35 73149 1733 46611145
Sudden death 56.35 14.66 72 73112 9432 46603446
Refusal of treatment by patient 56.28 14.66 55 73129 5360 46607518
Suicidal ideation 55.95 14.66 205 72979 56177 46556701
Obesity 55.22 14.66 88 73096 14118 46598760
Chest discomfort 54.95 14.66 37 73147 90232 46522646
Oculogyric crisis 54.21 14.66 30 73154 1203 46611675
Rash pruritic 53.93 14.66 4 73180 44211 46568667
Parkinsonism 53.21 14.66 64 73120 7884 46604994
Ileus paralytic 52.76 14.66 48 73136 4275 46608603
Blood glucose increased 52.52 14.66 238 72946 71775 46541103
Posture abnormal 52.04 14.66 36 73148 2154 46610724
Blister 51.80 14.66 5 73179 44626 46568252
Plasma cell myeloma 51.58 14.66 5 73179 44473 46568405
Bronchitis 51.53 14.66 54 73130 105925 46506953
Red blood cell count decreased 51.18 14.66 139 73045 32484 46580394
Epilepsy 50.89 14.66 114 73070 23624 46589254
Mania 50.39 14.66 73 73111 10773 46602105
Hot flush 50.18 14.66 5 73179 43512 46569366
Electrocardiogram T wave abnormal 49.81 14.66 36 73148 2310 46610568
Contusion 49.17 14.66 39 73145 87448 46525430
Blood urea decreased 48.62 14.66 35 73149 2232 46610646
Multiple sclerosis relapse 48.16 14.66 5 73179 42120 46570758
Parkinson's disease 48.03 14.66 30 73154 1509 46611369
Chills 47.75 14.66 48 73136 95984 46516894
Intentional product use issue 47.60 14.66 12 73172 52768 46560110
Hypokalaemia 47.29 14.66 41 73143 87983 46524895
Platelet count decreased 47.12 14.66 293 72891 99731 46513147
Overweight 46.95 14.66 39 73145 3074 46609804
Hypothermia 46.71 14.66 75 73109 12108 46600770
Dry skin 46.55 14.66 5 73179 41011 46571867
Blood alkaline phosphatase increased 46.23 14.66 152 73032 39457 46573421
Impaired healing 45.75 14.66 3 73181 36740 46576138
Osteoarthritis 45.64 14.66 20 73164 62005 46550873
Neck pain 45.42 14.66 15 73169 55291 46557587
Fibromyalgia 45.34 14.66 3 73181 36460 46576418
Pancreatic fibrosis 44.85 14.66 13 73171 85 46612793
Psychiatric evaluation 44.69 14.66 10 73174 17 46612861
Foreign body in gastrointestinal tract 44.33 14.66 10 73174 18 46612860
Malaise 44.28 14.66 747 72437 330485 46282393
Ileus 43.90 14.66 79 73105 13985 46598893
Medication error 43.87 14.66 127 73057 30784 46582094
Insomnia 43.55 14.66 124 73060 164800 46448078
Negativism 43.41 14.66 18 73166 374 46612504
Borderline personality disorder 43.40 14.66 22 73162 736 46612142
Weight decreased 43.14 14.66 177 73007 210672 46402206
Confusional state 43.09 14.66 411 72773 159481 46453397
Megacolon 43.04 14.66 29 73155 1662 46611216
Myocardial fibrosis 42.60 14.66 20 73164 564 46612314
Dyspnoea exertional 42.43 14.66 13 73171 50276 46562602
Wrong product administered 42.13 14.66 48 73136 5582 46607296
Inappropriate schedule of product administration 41.82 14.66 25 73159 64988 46547890
Insurance issue 41.72 14.66 29 73155 1749 46611129
Depressed level of consciousness 41.47 14.66 166 73018 47403 46565475
Thrombosis 41.38 14.66 18 73166 56051 46556827
Abdominal pain 41.13 14.66 203 72981 229828 46383050
Dizziness 41.08 14.66 339 72845 340075 46272803
Dysgeusia 41.06 14.66 7 73177 40484 46572394
Visual impairment 41.03 14.66 27 73157 66662 46546216
Feeling abnormal 40.94 14.66 84 73100 124976 46487902
Electrocardiogram T wave inversion 40.89 14.66 38 73146 3478 46609400
Vomiting 39.68 14.66 487 72697 452307 46160571
Discomfort 39.49 14.66 12 73172 46658 46566220
Haematochezia 39.10 14.66 6 73178 37487 46575391
Red blood cell count increased 38.72 14.66 31 73153 2319 46610559
Central obesity 38.55 14.66 21 73163 816 46612062
Benign ethnic neutropenia 38.22 14.66 7 73177 0 46612878
Loss of personal independence in daily activities 38.19 14.66 21 73163 57162 46555716
Pain in jaw 38.11 14.66 7 73177 38365 46574513
Cataract 37.85 14.66 12 73172 45403 46567475
Dysarthria 37.75 14.66 137 73047 37361 46575517
Oedema 37.56 14.66 30 73154 67041 46545837
Blood pressure increased 36.64 14.66 91 73093 126575 46486303
On and off phenomenon 36.56 14.66 28 73156 1963 46610915
Wound 36.23 14.66 11 73173 42791 46570087
Red cell distribution width increased 36.01 14.66 52 73132 7652 46605226
Electroconvulsive therapy 35.97 14.66 10 73174 55 46612823
Intentional overdose 35.58 14.66 198 72986 64746 46548132
Bradykinesia 35.22 14.66 37 73147 3929 46608949
Fluid retention 35.19 14.66 18 73166 51028 46561850
Urinary tract infection 35.18 14.66 512 72672 219754 46393124
Burning sensation 34.83 14.66 13 73171 44398 46568480
Cervix neoplasm 34.82 14.66 13 73171 202 46612676
International normalised ratio increased 34.68 14.66 15 73169 46868 46566010
Akinesia 34.55 14.66 26 73158 1775 46611103
Persecutory delusion 34.42 14.66 30 73154 2525 46610353
Interstitial lung disease 34.34 14.66 21 73163 53928 46558950
Skin ulcer 34.30 14.66 5 73179 32453 46580425
Rebound psychosis 34.28 14.66 8 73176 18 46612860
Social avoidant behaviour 33.63 14.66 31 73153 2808 46610070
Atrial fibrillation 33.54 14.66 70 73114 103520 46509358
Type 2 diabetes mellitus 33.52 14.66 87 73097 19788 46593090
Angioedema 33.50 14.66 10 73174 39332 46573546
Suicidal behaviour 33.49 14.66 29 73155 2419 46610459
Rhinorrhoea 32.57 14.66 17 73167 47648 46565230
Monocytosis 32.53 14.66 14 73170 320 46612558
Muscular weakness 32.39 14.66 59 73125 91785 46521093
Product quality issue 32.35 14.66 8 73176 35640 46577238
Device expulsion 32.19 14.66 3 73181 27539 46585339
Intestinal strangulation 32.12 14.66 10 73174 86 46612792
Cardiac steatosis 31.71 14.66 9 73175 54 46612824
Parotitis 31.13 14.66 21 73163 1206 46611672
Hyperkalaemia 30.56 14.66 21 73163 50688 46562190
Granulocytosis 30.52 14.66 9 73175 63 46612815
Waxy flexibility 30.51 14.66 10 73174 103 46612775
Abnormal clotting factor 30.34 14.66 10 73174 105 46612773
Accidental exposure to product 30.28 14.66 87 73097 20994 46591884
Eye pain 30.24 14.66 4 73180 27936 46584942
Bipolar disorder 30.04 14.66 46 73138 7131 46605747
Osteoporosis 30.02 14.66 13 73171 40595 46572283
Parkinsonism hyperpyrexia syndrome 30.00 14.66 11 73173 162 46612716
Serositis 29.94 14.66 16 73168 598 46612280
Cardiomyopathy 29.87 14.66 73 73111 16000 46596878
Osteonecrosis 29.57 14.66 3 73181 25741 46587137
Haematocrit increased 29.48 14.66 23 73161 1657 46611221
Pseudophaeochromocytoma 29.37 14.66 9 73175 73 46612805
Eosinopenia 29.13 14.66 6 73178 5 46612873
Drug monitoring procedure incorrectly performed 29.06 14.66 10 73174 121 46612757
Dehydration 28.95 14.66 140 73044 159400 46453478
Gastrointestinal haemorrhage 28.83 14.66 48 73136 77325 46535553
Gastrooesophageal reflux disease 28.75 14.66 45 73139 74299 46538579
Hypocalcaemia 28.59 14.66 4 73180 26781 46586097
Suspected COVID-19 28.53 14.66 15 73169 542 46612336
Tobacco interaction 28.30 14.66 7 73177 22 46612856
Oral pain 28.20 14.66 3 73181 24794 46588084
Swelling face 28.15 14.66 25 73159 53034 46559844
Cardiac failure congestive 28.05 14.66 64 73120 91686 46521192
Productive cough 28.00 14.66 23 73161 50692 46562186
Echocardiogram abnormal 27.96 14.66 18 73166 955 46611923
Gamma-glutamyltransferase increased 27.85 14.66 111 73073 31629 46581249
Therapeutic product effect incomplete 27.74 14.66 50 73134 78103 46534775
Hypertension 27.71 14.66 187 72997 196169 46416709
Loss of consciousness 27.55 14.66 275 72909 107963 46504915
Visceral congestion 27.38 14.66 12 73172 287 46612591
Ankle fracture 27.30 14.66 69 73115 15442 46597436
Hepatic steatosis 26.93 14.66 91 73093 23951 46588927
Fluid overload 26.91 14.66 5 73179 27180 46585698
Seizure 26.81 14.66 303 72881 122751 46490127
Neutrophil toxic granulation present 26.80 14.66 7 73177 29 46612849
Body mass index increased 26.80 14.66 18 73166 1026 46611852
Full blood count abnormal 26.76 14.66 21 73163 1526 46611352
Stoma site discharge 26.58 14.66 23 73161 1917 46610961
Affective disorder 26.25 14.66 35 73149 4780 46608098
Bundle branch block right 26.22 14.66 35 73149 4784 46608094
Toxicity to various agents 26.22 14.66 472 72712 211294 46401584
Rash maculo-papular 25.79 14.66 6 73178 27868 46585010
Swollen tongue 25.68 14.66 7 73177 29225 46583653
Hyponatraemia 25.42 14.66 78 73106 101254 46511624
Rash erythematous 25.39 14.66 11 73173 34339 46578539
Diverticulitis 25.36 14.66 10 73174 33029 46579849
Dry eye 25.29 14.66 8 73176 30314 46582564
Influenza B virus test positive 25.06 14.66 12 73172 354 46612524
Globulin abnormal 24.95 14.66 5 73179 3 46612875
Subileus 24.87 14.66 27 73157 2976 46609902
Chemotherapy 24.79 14.66 19 73165 1333 46611545
Sinus rhythm 24.64 14.66 14 73170 591 46612287
Miosis 24.19 14.66 40 73144 6617 46606261
Cardiac arrest 24.13 14.66 232 72952 90167 46522711
Blood albumin decreased 24.04 14.66 61 73123 13684 46599194
Pericarditis 23.72 14.66 87 73097 23840 46589038
Stevens-Johnson syndrome 23.68 14.66 4 73180 23293 46589585
Parotid gland enlargement 23.58 14.66 15 73169 779 46612099
Haemoptysis 23.52 14.66 6 73178 26183 46586695
Eye movement disorder 23.35 14.66 33 73151 4760 46608118
Vision blurred 23.24 14.66 57 73127 79651 46533227
Self-injurious ideation 23.23 14.66 23 73161 2277 46610601
Drug level above therapeutic 23.07 14.66 28 73156 3481 46609397
Microcytosis 23.05 14.66 9 73175 159 46612719
Dysphonia 23.02 14.66 16 73168 38398 46574480
Hepatitis C 23.01 14.66 38 73146 6280 46606598
Wheezing 22.93 14.66 30 73154 53356 46559522
Basophil count increased 22.91 14.66 15 73169 819 46612059
Ovarian cancer 22.85 14.66 36 73148 5719 46607159
Poor personal hygiene 22.83 14.66 11 73173 329 46612549
Musculoskeletal stiffness 22.79 14.66 78 73106 97915 46514963
Malignant catatonia 22.76 14.66 6 73178 26 46612852
Dysphemia 22.75 14.66 23 73161 2335 46610543
Body mass index decreased 22.71 14.66 11 73173 333 46612545
Contraindicated product administered 22.67 14.66 58 73126 79889 46532989
Fungal infection 22.55 14.66 9 73175 29511 46583367
Neoplasm progression 22.32 14.66 7 73177 26676 46586202
Cystitis 22.29 14.66 20 73164 42221 46570657
Echolalia 22.21 14.66 9 73175 176 46612702
Gastrointestinal disorder 22.16 14.66 37 73147 59539 46553339
Bradycardia 22.13 14.66 44 73140 66254 46546624
Skin exfoliation 22.13 14.66 12 73172 32926 46579952
Basal cell carcinoma 22.01 14.66 3 73181 20484 46592394
Neutrophil percentage increased 21.98 14.66 24 73160 2663 46610215
Intestinal dilatation 21.96 14.66 19 73165 1583 46611295
Wrong technique in product usage process 21.95 14.66 32 73152 54390 46558488
Hepatotoxicity 21.95 14.66 6 73178 25003 46587875
Activated partial thromboplastin time abnormal 21.93 14.66 8 73176 116 46612762
Poverty of speech 21.91 14.66 10 73174 264 46612614
Hyperkinesia 21.88 14.66 20 73164 1792 46611086
Neutrophil count normal 21.84 14.66 4 73180 0 46612878
Skin discolouration 21.82 14.66 12 73172 32668 46580210
Laryngeal cancer stage III 21.82 14.66 5 73179 10 46612868
Flatulence 21.74 14.66 9 73175 28869 46584009
Polyserositis 21.56 14.66 10 73174 274 46612604
Pulmonary fibrosis 21.45 14.66 3 73181 20089 46592789
Palpitations 21.36 14.66 77 73107 95182 46517696
Hepatic enzyme increased 21.19 14.66 62 73122 81725 46531153
Cerebral haemorrhage 21.10 14.66 9 73175 28362 46584516
Liver function test increased 20.95 14.66 5 73179 22821 46590057
Lung carcinoma cell type unspecified stage III 20.86 14.66 6 73178 38 46612840
Nephrolithiasis 20.85 14.66 13 73171 33038 46579840
SARS-CoV-2 test positive 20.85 14.66 20 73164 1905 46610973
Haematuria 20.83 14.66 8 73176 26850 46586028
Laparotomy 20.77 14.66 8 73176 136 46612742
Incontinence 20.73 14.66 47 73137 9815 46603063
Depression 20.65 14.66 169 73015 169935 46442943
Vertigo 20.61 14.66 31 73153 52017 46560861
Cervix cancer metastatic 20.60 14.66 6 73178 40 46612838
Upper respiratory tract infection 20.52 14.66 43 73141 63513 46549365
Chest pain 20.14 14.66 178 73006 176146 46436732
Sciatica 19.93 14.66 3 73181 19017 46593861
Infection 19.92 14.66 307 72877 133285 46479593
Nervousness 19.69 14.66 10 73174 28465 46584413
Brain neoplasm 19.63 14.66 27 73157 3797 46609081
Sexually inappropriate behaviour 19.61 14.66 7 73177 95 46612783
Catecholamines urine increased 19.49 14.66 5 73179 19 46612859
Haematoma 19.47 14.66 13 73171 31859 46581019
Influenza 19.46 14.66 73 73111 89197 46523681
Hallucination, visual 19.44 14.66 67 73117 17806 46595072
Therapy cessation 19.39 14.66 88 73096 26541 46586337
Life support 19.23 14.66 9 73175 252 46612626
Dementia with Lewy bodies 19.16 14.66 9 73175 254 46612624
Blood bicarbonate increased 19.11 14.66 13 73171 757 46612121
Normal newborn 19.10 14.66 34 73150 5967 46606911
Product administration error 19.04 14.66 71 73113 19610 46593268
Pulmonary hypertension 19.04 14.66 17 73167 35976 46576902
Lip swelling 18.98 14.66 8 73176 25387 46587491
C-reactive protein abnormal 18.86 14.66 5 73179 21265 46591613
Eczema eyelids 18.86 14.66 7 73177 107 46612771
Melaena 18.83 14.66 10 73174 27762 46585116
Intentional product misuse 18.73 14.66 28 73156 47100 46565778
Hypoacusis 18.46 14.66 5 73179 20964 46591914
Toxic epidermal necrolysis 18.36 14.66 6 73178 22272 46590606
Intestinal pseudo-obstruction 18.33 14.66 12 73172 655 46612223
Hypochromasia 18.27 14.66 9 73175 283 46612595
Pancytopenia 18.26 14.66 70 73114 84988 46527890
Liver function test abnormal 18.14 14.66 130 73054 46357 46566521
Colitis ulcerative 18.12 14.66 3 73181 17729 46595149
Persistent depressive disorder 18.07 14.66 14 73170 998 46611880
Rectal haemorrhage 18.02 14.66 20 73164 38235 46574643
Imprisonment 17.96 14.66 8 73176 199 46612679
Coronary artery disease 17.78 14.66 16 73168 33736 46579142
Vascular encephalopathy 17.73 14.66 10 73174 416 46612462
Asterixis 17.69 14.66 15 73169 1216 46611662
Obsessive-compulsive symptom 17.62 14.66 5 73179 30 46612848
Wrong drug 17.56 14.66 7 73177 131 46612747
Unresponsive to stimuli 17.55 14.66 98 73086 32076 46580802
Foreign body 17.46 14.66 18 73166 1870 46611008
Appendicitis 17.44 14.66 34 73150 6392 46606486
Condition aggravated 17.31 14.66 275 72909 244777 46368101
Arteriosclerosis coronary artery 17.29 14.66 39 73145 8117 46604761
Blood triglycerides increased 17.28 14.66 49 73135 11734 46601144
Disorientation 17.27 14.66 108 73076 36810 46576068
Freezing phenomenon 17.25 14.66 16 73168 1461 46611417
Illness anxiety disorder 17.08 14.66 7 73177 141 46612737
Osteopenia 17.05 14.66 3 73181 16958 46595920
White blood cell disorder 16.99 14.66 18 73166 1930 46610948
Gestational diabetes 16.98 14.66 36 73148 7183 46605695
Hallucination, olfactory 16.96 14.66 8 73176 228 46612650
Faeces discoloured 16.80 14.66 3 73181 16784 46596094
Stupor 16.80 14.66 24 73160 3496 46609382
Thrombocytosis 16.77 14.66 29 73155 4973 46607905
Device related infection 16.76 14.66 6 73178 21035 46591843
Lymphocyte percentage increased 16.73 14.66 9 73175 341 46612537
Ischaemic stroke 16.71 14.66 3 73181 16719 46596159
Femur fracture 16.71 14.66 20 73164 36977 46575901
Coma 16.69 14.66 152 73032 58197 46554681
Gallbladder cholesterolosis 16.62 14.66 12 73172 769 46612109
Musculoskeletal chest pain 16.55 14.66 4 73180 18102 46594776
Cholestasis 16.39 14.66 11 73173 26882 46585996
Phobic avoidance 16.38 14.66 3 73181 0 46612878
Myelocyte present 16.38 14.66 3 73181 0 46612878
Stoma site erythema 16.37 14.66 14 73170 1148 46611730
Appendicitis perforated 16.23 14.66 16 73168 1575 46611303
Heart rate increased 16.20 14.66 184 73000 74607 46538271
Eosinophilic myocarditis 16.19 14.66 9 73175 364 46612514
Suspiciousness 16.19 14.66 9 73175 364 46612514
Skin lesion 16.18 14.66 11 73173 26702 46586176
Sedation complication 16.16 14.66 24 73160 3621 46609257
Corneal pigmentation 16.07 14.66 4 73180 13 46612865
Gastrointestinal lymphoma 15.96 14.66 5 73179 44 46612834
Metamyelocyte count increased 15.91 14.66 7 73177 169 46612709
Irregular breathing 15.77 14.66 8 73176 268 46612610
Limb discomfort 15.74 14.66 8 73176 22768 46590110
Hypoglycaemia 15.74 14.66 39 73145 54310 46558568
Clostridium difficile infection 15.66 14.66 10 73174 25093 46587785
Stoma site irritation 15.61 14.66 8 73176 274 46612604
Glaucoma 15.61 14.66 3 73181 15918 46596960
Monocyte percentage increased 15.59 14.66 13 73171 1030 46611848
Haemorrhoids 15.58 14.66 5 73179 18772 46594106
Localised infection 15.52 14.66 9 73175 23792 46589086
Gastric lavage 15.48 14.66 5 73179 49 46612829
Staring 15.40 14.66 15 73169 1455 46611423
Acne 15.33 14.66 6 73178 19913 46592965
Metastases to spine 15.33 14.66 20 73164 2674 46610204
Joint stiffness 15.33 14.66 12 73172 27096 46585782
Drug dependence 15.31 14.66 6 73178 19895 46592983
Grandiosity 15.26 14.66 7 73177 187 46612691
Palliative care 15.19 14.66 8 73176 290 46612588
Hallucinations, mixed 15.17 14.66 24 73160 3825 46609053
Nodule 15.17 14.66 3 73181 15602 46597276
Polydipsia 15.13 14.66 22 73162 3257 46609621
Neglect of personal appearance 15.11 14.66 6 73178 111 46612767
Thought blocking 15.06 14.66 6 73178 112 46612766
Impulsive behaviour 15.02 14.66 15 73169 1500 46611378
Nuchal rigidity 14.95 14.66 10 73174 566 46612312
Granulocyte count increased 14.94 14.66 8 73176 300 46612578
Tooth disorder 14.93 14.66 9 73175 23294 46589584
Fibroma 14.77 14.66 12 73172 917 46611961
Alcohol poisoning 14.75 14.66 18 73166 2250 46610628
Eye disorder 14.75 14.66 5 73179 18136 46594742
Red blood cell nucleated morphology present 14.70 14.66 4 73180 20 46612858
Huntington's disease 14.70 14.66 4 73180 20 46612858
Diplopia 14.68 14.66 6 73178 19399 46593479

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 4436.51 14.49 2551 118050 41768 29790109
Neutrophil count increased 4201.10 14.49 1757 118844 13566 29818311
Schizophrenia 3884.73 14.49 1436 119165 7612 29824265
White blood cell count increased 3668.00 14.49 2170 118431 37503 29794374
Granulocytopenia 3399.44 14.49 1181 119420 5045 29826832
Neutropenia 2567.88 14.49 2859 117742 125681 29706196
Differential white blood cell count abnormal 2321.23 14.49 615 119986 689 29831188
Neutrophilia 1935.29 14.49 666 119935 2741 29829136
Antipsychotic drug level increased 1744.43 14.49 605 119996 2561 29829316
Myocarditis 1585.40 14.49 784 119817 9227 29822650
Psychotic disorder 1533.77 14.49 999 119602 20516 29811361
Salivary hypersecretion 1343.81 14.49 641 119960 6925 29824952
Agranulocytosis 1308.11 14.49 912 119689 21030 29810847
Mental impairment 1285.89 14.49 664 119937 8613 29823264
Neutrophil count decreased 1282.67 14.49 1184 119417 41270 29790607
Death 1200.06 14.49 3642 116959 353641 29478236
White blood cell count decreased 1136.35 14.49 1538 119063 82409 29749468
Neuroleptic malignant syndrome 841.65 14.49 621 119980 15674 29816203
Sedation 798.81 14.49 603 119998 15770 29816107
Tachycardia 787.57 14.49 1208 119393 72531 29759346
Platelet count increased 625.03 14.49 407 120194 8335 29823542
Leukopenia 593.54 14.49 916 119685 55243 29776634
Antipsychotic drug level decreased 580.83 14.49 192 120409 676 29831201
Eosinophil count increased 551.65 14.49 355 120246 7118 29824759
Lower respiratory tract infection 512.54 14.49 584 120017 26130 29805747
Mental disorder 499.17 14.49 422 120179 13027 29818850
Hallucination, auditory 493.96 14.49 368 120233 9421 29822456
Antipsychotic drug level below therapeutic 484.33 14.49 189 120412 1183 29830694
C-reactive protein increased 461.81 14.49 711 119890 42762 29789115
Troponin increased 431.39 14.49 326 120275 8531 29823346
Antipsychotic drug level above therapeutic 426.37 14.49 161 120440 909 29830968
Rash 421.69 14.49 125 120476 191764 29640113
Acute kidney injury 405.72 14.49 307 120294 273535 29558342
Treatment noncompliance 395.54 14.49 498 120103 24755 29807122
Diarrhoea 384.19 14.49 470 120131 333633 29498244
Fatigue 381.61 14.49 439 120162 320234 29511643
Nausea 379.41 14.49 383 120218 296574 29535303
Catatonia 378.50 14.49 230 120371 4150 29827727
Arthralgia 368.75 14.49 54 120547 135737 29696140
Pruritus 363.84 14.49 30 120571 118174 29713703
Blood creatine phosphokinase increased 343.75 14.49 626 119975 43222 29788655
Leukocytosis 328.74 14.49 419 120182 21083 29810794
Pain 324.12 14.49 145 120456 172496 29659381
Delusion 300.28 14.49 302 120299 11687 29820190
Monocyte count increased 295.74 14.49 183 120418 3415 29828462
Headache 293.95 14.49 186 120415 182120 29649757
Sinus tachycardia 292.27 14.49 336 120265 15168 29816709
Eosinophil count decreased 287.63 14.49 124 120477 1033 29830844
Febrile neutropenia 277.00 14.49 48 120553 106645 29725232
Faecaloma 271.33 14.49 187 120414 4218 29827659
Malignant neoplasm progression 262.10 14.49 6 120595 72281 29759596
Asthenia 255.12 14.49 310 120291 220980 29610897
Psychiatric decompensation 253.62 14.49 118 120483 1197 29830680
Dyspnoea 250.90 14.49 613 119988 332682 29499195
Pain in extremity 250.71 14.49 67 120534 110154 29721723
Obsessive-compulsive disorder 246.17 14.49 172 120429 3969 29827908
Off label use 236.33 14.49 401 120200 248889 29582988
Neuropathy peripheral 234.11 14.49 12 120589 70463 29761414
Malaise 230.56 14.49 1299 119302 165663 29666214
Decreased appetite 224.10 14.49 166 120435 149744 29682133
Haemoglobin decreased 222.24 14.49 979 119622 113119 29718758
Hyperkalaemia 213.82 14.49 13 120588 65997 29765880
Pneumonia aspiration 201.53 14.49 460 120141 37320 29794557
Disease progression 200.66 14.49 39 120562 79835 29752042
Atrial fibrillation 199.29 14.49 93 120508 108031 29723846
Paranoia 199.12 14.49 225 120376 9963 29821914
Erythema 194.17 14.49 38 120563 77413 29754464
Pre-existing disease 193.86 14.49 51 120550 54 29831823
Cardiomyopathy 191.43 14.49 269 120332 14874 29817003
Lung neoplasm malignant 190.09 14.49 268 120333 14864 29817013
Peripheral swelling 189.18 14.49 15 120586 61059 29770818
Mean cell volume decreased 188.81 14.49 92 120509 1043 29830834
Lymphocyte count increased 188.15 14.49 121 120480 2421 29829456
Back pain 186.38 14.49 90 120511 102506 29729371
Drooling 186.09 14.49 128 120473 2877 29829000
Oedema peripheral 184.53 14.49 98 120503 105734 29726143
Electrocardiogram QT prolonged 182.00 14.49 428 120173 35407 29796470
Aggression 180.09 14.49 434 120167 36473 29795404
Urticaria 176.10 14.49 11 120590 54595 29777282
Drug hypersensitivity 168.86 14.49 35 120566 68484 29763393
Plasma cell myeloma 168.79 14.49 12 120589 53450 29778427
Mean cell haemoglobin decreased 166.67 14.49 86 120515 1111 29830766
Eosinophilia 164.26 14.49 309 120292 21851 29810026
Gastrointestinal hypomotility 160.73 14.49 79 120522 914 29830963
Agitation 159.65 14.49 530 120071 53543 29778334
Extrapyramidal disorder 159.64 14.49 206 120395 10487 29821390
Interstitial lung disease 158.53 14.49 26 120575 60171 29771706
Neoplasm malignant 158.47 14.49 269 120332 17545 29814332
Abnormal behaviour 158.25 14.49 331 120270 25292 29806585
Joint swelling 155.86 14.49 8 120593 46938 29784939
Anosognosia 155.06 14.49 69 120532 625 29831252
Circulatory collapse 154.99 14.49 286 120315 19928 29811949
Epistaxis 153.48 14.49 17 120584 52964 29778913
Body temperature increased 152.93 14.49 239 120362 14541 29817336
General physical condition abnormal 151.15 14.49 119 120482 3311 29828566
Obesity 148.88 14.49 178 120423 8377 29823500
Anaemia 147.96 14.49 393 120208 207599 29624278
Drug level increased 147.46 14.49 265 120336 18089 29813788
Schizoaffective disorder 147.14 14.49 76 120525 984 29830893
Imprisonment 145.94 14.49 60 120541 438 29831439
Electrocardiogram abnormal 143.09 14.49 146 120455 5746 29826131
Psychotic symptom 141.70 14.49 77 120524 1112 29830765
Muscle rigidity 139.78 14.49 189 120412 10072 29821805
Platelet count decreased 136.57 14.49 811 119790 105318 29726559
Muscle spasms 135.40 14.49 46 120555 64792 29767085
International normalised ratio increased 134.11 14.49 17 120584 47722 29784155
Pericarditis 130.36 14.49 167 120434 8439 29823438
Enuresis 130.20 14.49 84 120517 1690 29830187
Left ventricular hypertrophy 128.41 14.49 142 120459 6136 29825741
Akathisia 126.78 14.49 137 120464 5767 29826110
Dyskinesia 125.54 14.49 274 120327 21560 29810317
Hypoaesthesia 125.04 14.49 32 120569 54198 29777679
Stomatitis 124.87 14.49 6 120595 37273 29794604
Paraesthesia 123.47 14.49 33 120568 54294 29777583
Left ventricular dysfunction 122.85 14.49 163 120438 8528 29823349
Rheumatoid arthritis 122.46 14.49 12 120589 41185 29790692
Cardiac failure congestive 120.23 14.49 98 120503 84309 29747568
Heart rate increased 120.07 14.49 386 120215 38335 29793542
Renal failure 118.65 14.49 211 120390 128755 29703122
Intestinal obstruction 118.40 14.49 248 120353 18964 29812913
Persecutory delusion 118.20 14.49 85 120516 2055 29829822
Red blood cell count decreased 117.26 14.49 299 120302 26022 29805855
Myalgia 116.88 14.49 83 120518 76584 29755293
Haemoglobin increased 115.80 14.49 95 120506 2807 29829070
Aspiration 115.30 14.49 175 120426 10376 29821501
Myoclonus 114.42 14.49 198 120403 13114 29818763
Mean cell volume increased 110.16 14.49 81 120520 2029 29829848
Drug ineffective 108.98 14.49 864 119737 339523 29492354
Hypersensitivity 106.59 14.49 42 120559 53986 29777891
Tardive dyskinesia 106.23 14.49 116 120485 4941 29826936
Psoriasis 106.18 14.49 21 120580 42485 29789392
Refusal of examination 105.64 14.49 24 120577 3 29831874
Hepatitis C 103.95 14.49 189 120412 13016 29818861
Thinking abnormal 103.27 14.49 117 120484 5194 29826683
Echocardiogram abnormal 103.10 14.49 53 120548 679 29831198
Mucosal inflammation 101.83 14.49 5 120596 30489 29801388
Troponin T increased 101.43 14.49 66 120535 1348 29830529
Anaphylactic reaction 98.84 14.49 3 120598 27979 29803898
Hypoglycaemia 98.34 14.49 41 120560 50940 29780937
Lymphocyte count decreased 98.24 14.49 229 120372 18826 29813051
Injection site pain 98.02 14.49 6 120595 30304 29801573
Choking 97.94 14.49 110 120491 4836 29827041
Thrombosis 97.20 14.49 25 120576 42206 29789671
Body mass index increased 96.48 14.49 50 120551 652 29831225
Overdose 95.59 14.49 624 119977 83713 29748164
Dystonia 94.71 14.49 153 120448 9574 29822303
Haematochezia 94.17 14.49 13 120588 34209 29797668
Blood prolactin abnormal 93.94 14.49 50 120551 691 29831186
Pancytopenia 93.71 14.49 123 120478 84929 29746948
Psychiatric symptom 93.67 14.49 90 120511 3289 29828588
Chills 93.40 14.49 92 120509 72246 29759631
Lactic acidosis 93.00 14.49 9 120592 31204 29800673
Benign ethnic neutropenia 91.91 14.49 22 120579 9 29831868
Dizziness 91.85 14.49 438 120163 194471 29637406
Somnolence 90.94 14.49 684 119917 96079 29735798
Megacolon 89.66 14.49 65 120536 1592 29830285
Ileus paralytic 89.34 14.49 112 120489 5536 29826341
Seizure 88.02 14.49 688 119913 97787 29734090
Gastrointestinal haemorrhage 87.58 14.49 125 120476 83321 29748556
Bradycardia 87.32 14.49 81 120520 65445 29766432
Cough 87.22 14.49 240 120361 125402 29706475
Intentional product use issue 86.93 14.49 20 120581 36420 29795457
Musculoskeletal pain 86.93 14.49 11 120590 30929 29800948
Hypokalaemia 86.64 14.49 47 120554 50145 29781732
Sinusitis 86.44 14.49 15 120586 33330 29798547
Parkinson's disease 84.99 14.49 64 120537 1664 29830213
Delirium 84.55 14.49 356 120245 40275 29791602
Neutrophil count abnormal 83.80 14.49 58 120543 1317 29830560
Living in residential institution 80.52 14.49 31 120570 186 29831691
Dysgeusia 79.93 14.49 5 120596 24796 29807081
Generalised tonic-clonic seizure 79.82 14.49 215 120386 19336 29812541
Melaena 79.00 14.49 17 120584 32420 29799457
Coma scale abnormal 78.98 14.49 82 120519 3294 29828583
Hepatitis C virus test positive 78.90 14.49 38 120563 419 29831458
Drug reaction with eosinophilia and systemic symptoms 77.96 14.49 11 120590 28477 29803400
Tobacco interaction 77 14.49 24 120577 66 29831811
Psychiatric evaluation 76.82 14.49 17 120584 0 29831877
Mean cell haemoglobin concentration decreased 76.59 14.49 49 120552 971 29830906
Swelling 74.25 14.49 26 120575 35949 29795928
Disturbance in social behaviour 73.50 14.49 55 120546 1416 29830461
Muscular weakness 73.25 14.49 89 120512 63556 29768321
Oedema 73.13 14.49 41 120560 42952 29788925
Haematuria 73.08 14.49 45 120556 44789 29787088
Coronavirus infection 73.06 14.49 80 120521 3418 29828459
Terminal state 72.81 14.49 81 120520 3523 29828354
Therapy cessation 71.65 14.49 176 120425 14961 29816916
Ascites 70.71 14.49 28 120573 35893 29795984
Blood prolactin increased 70.68 14.49 53 120548 1369 29830508
Renal impairment 70.14 14.49 146 120455 84038 29747839
Suicide attempt 69.82 14.49 313 120288 36384 29795493
Vision blurred 69.52 14.49 41 120560 41775 29790102
Herpes zoster 68.37 14.49 18 120583 29925 29801952
Cardiac disorder 67.63 14.49 329 120272 39564 29792313
Apathy 67.57 14.49 103 120498 6129 29825748
Colitis ischaemic 67.55 14.49 99 120502 5687 29826190
Overweight 67.09 14.49 52 120549 1413 29830464
Constipation 66.90 14.49 722 119879 112184 29719693
Dehydration 65.77 14.49 265 120336 123274 29708603
Disinhibition 65.67 14.49 58 120543 1899 29829978
Therapeutic product effect variable 65.13 14.49 50 120551 1339 29830538
Acute myocardial infarction 64.19 14.49 71 120530 52868 29779009
Angioedema 64.16 14.49 29 120572 34355 29797522
Haematoma 63.81 14.49 10 120591 23943 29807934
Oculogyric crisis 63.39 14.49 49 120552 1326 29830551
Haematocrit decreased 63.09 14.49 268 120333 30431 29801446
Dyspnoea exertional 62.88 14.49 32 120569 35398 29796479
Sudden death 62.87 14.49 170 120431 15322 29816555
Congestive cardiomyopathy 62.83 14.49 103 120498 6524 29825353
Inappropriate schedule of product administration 61.85 14.49 42 120559 39686 29792191
Intestinal dilatation 61.48 14.49 45 120556 1119 29830758
Cerebral haemorrhage 60.96 14.49 28 120573 32859 29799018
Social avoidant behaviour 60.70 14.49 66 120535 2797 29829080
Blood triglycerides increased 60.11 14.49 157 120444 13860 29818017
Drug monitoring procedure incorrectly performed 59.23 14.49 24 120577 168 29831709
Arthritis 58.99 14.49 13 120588 24388 29807489
Weight decreased 58.93 14.49 361 120240 150560 29681317
Abdominal pain upper 58.66 14.49 101 120500 62450 29769427
Ejection fraction decreased 58.08 14.49 163 120438 15012 29816865
Gastrointestinal carcinoma 58.03 14.49 41 120560 963 29830914
Viral infection 58.02 14.49 163 120438 15022 29816855
Coronary artery disease 57.75 14.49 69 120532 49643 29782234
COVID-19 57.00 14.49 180 120421 17698 29814179
Troponin I increased 56.91 14.49 52 120549 1781 29830096
Full blood count abnormal 56.91 14.49 42 120559 1058 29830819
Pneumocystis jirovecii pneumonia 56.55 14.49 3 120598 17117 29814760
Pneumonitis 56.38 14.49 20 120581 27434 29804443
Abdominal discomfort 56.38 14.49 68 120533 48723 29783154
Influenza like illness 56.12 14.49 228 120373 25377 29806500
Haemorrhage 55.64 14.49 62 120539 46017 29785860
Orthostatic hypotension 55.35 14.49 217 120384 23762 29808115
Fluid retention 55.26 14.49 16 120585 24982 29806895
Lung cancer metastatic 54.87 14.49 59 120542 2469 29829408
Parkinsonism 54.64 14.49 102 120499 7167 29824710
Rash pruritic 54.61 14.49 12 120589 22560 29809317
Arthropathy 54.44 14.49 9 120592 20718 29811159
Impaired self-care 54.25 14.49 38 120563 880 29830997
Rebound psychosis 53.99 14.49 21 120580 130 29831747
Alopecia 53.79 14.49 7 120594 19268 29812609
Intentional self-injury 53.42 14.49 147 120454 13385 29818492
Wheezing 53.34 14.49 29 120572 30909 29800968
Cholestasis 53.29 14.49 17 120584 24933 29806944
Ventricular tachycardia 53.25 14.49 15 120586 23847 29808030
Rectal haemorrhage 52.99 14.49 38 120563 34901 29796976
Skin exfoliation 52.77 14.49 14 120587 23158 29808719
Insomnia 52.35 14.49 196 120405 93140 29738737
Dry skin 52.22 14.49 13 120588 22441 29809436
Rash erythematous 52.22 14.49 13 120588 22439 29809438
Cerebral infarction 51.18 14.49 21 120580 26352 29805525
Metabolic syndrome 50.85 14.49 45 120556 1477 29830400
Electrocardiogram T wave abnormal 50.04 14.49 43 120558 1356 29830521
Metabolic disorder 49.92 14.49 67 120534 3544 29828333
Rash maculo-papular 49.72 14.49 20 120581 25398 29806479
Basophil count increased 49.71 14.49 26 120575 346 29831531
Red blood cell count increased 49.25 14.49 43 120558 1386 29830491
Hepatic failure 49.09 14.49 39 120562 34004 29797873
Flushing 48.90 14.49 29 120572 29463 29802414
Intestinal pseudo-obstruction 48.86 14.49 39 120562 1107 29830770
Full blood count decreased 48.25 14.49 4 120597 15713 29816164
Osteoarthritis 48.12 14.49 8 120593 18341 29813536
Multiple organ dysfunction syndrome 48.05 14.49 116 120485 63371 29768506
Type 2 diabetes mellitus 47.96 14.49 142 120459 13480 29818397
Hyperbilirubinaemia 47.65 14.49 6 120595 16936 29814941
Ventricular hypokinesia 47.49 14.49 71 120530 4152 29827725
Myelodysplastic syndrome 47.47 14.49 9 120592 18769 29813108
Blood creatinine increased 47.36 14.49 198 120403 91177 29740700
Refusal of treatment by patient 47.18 14.49 78 120523 4975 29826902
Lymphoma 47.17 14.49 117 120484 10004 29821873
Pericardial effusion 46.91 14.49 189 120412 20955 29810922
Testis cancer 46.86 14.49 28 120573 489 29831388
Bronchitis 46.84 14.49 53 120548 39072 29792805
Oesophageal carcinoma 46.73 14.49 61 120540 3140 29828737
Blood urea decreased 46.67 14.49 36 120565 971 29830906
Hypocalcaemia 46.67 14.49 14 120587 21362 29810515
Skin lesion 46.46 14.49 9 120592 18485 29813392
Device related infection 45.56 14.49 7 120594 17008 29814869
Neutrophil count normal 45.19 14.49 10 120591 0 29831877
Visual impairment 44.99 14.49 34 120567 30404 29801473
Obsessive thoughts 44.92 14.49 30 120571 641 29831236
Osteonecrosis 44.69 14.49 6 120595 16129 29815748
Globulins decreased 44.39 14.49 20 120581 187 29831690
Blister 44.33 14.49 14 120587 20669 29811208
Weight increased 44.30 14.49 479 120122 74434 29757443
Bone pain 44.28 14.49 11 120590 19015 29812862
Polydipsia psychogenic 43.88 14.49 17 120584 104 29831773
Hepatic function abnormal 43.81 14.49 63 120538 41882 29789995
Dilatation ventricular 43.75 14.49 54 120547 2626 29829251
On and off phenomenon 43.62 14.49 56 120545 2835 29829042
Waist circumference increased 43.62 14.49 29 120572 615 29831262
Sedation complication 43.50 14.49 32 120569 802 29831075
Product quality issue 43.41 14.49 11 120590 18763 29813114
Respiratory failure 43.41 14.49 233 120368 100409 29731468
Nephrolithiasis 43.14 14.49 23 120578 24787 29807090
Deep vein thrombosis 43.11 14.49 114 120487 60387 29771490
Haemoptysis 43.08 14.49 37 120564 31041 29800836
Impaired healing 43.07 14.49 4 120597 14336 29817541
Urinary tract infection 42.64 14.49 469 120132 73190 29758687
Mean cell haemoglobin concentration increased 42.51 14.49 22 120579 286 29831591
Disseminated intravascular coagulation 42.47 14.49 18 120583 22153 29809724
Bundle branch block right 42.32 14.49 90 120511 6952 29824925
Gout 42.31 14.49 9 120592 17306 29814571
Electroencephalogram abnormal 42.29 14.49 50 120551 2324 29829553
Basal cell carcinoma 42.14 14.49 7 120594 16061 29815816
Urinary incontinence 42.13 14.49 157 120444 16783 29815094
Red cell distribution width increased 42.05 14.49 66 120535 4028 29827849
Diabetes mellitus 41.58 14.49 300 120301 41565 29790312
Hypotension 41.35 14.49 564 120037 200001 29631876
Hepatotoxicity 41.25 14.49 11 120590 18134 29813743
Drug-induced liver injury 41.19 14.49 17 120584 21257 29810620
Hallucination 41.17 14.49 338 120263 48721 29783156
Acute psychosis 41.10 14.49 44 120557 1832 29830045
Drug dose titration not performed 41.02 14.49 20 120581 227 29831650
Delusional disorder, persecutory type 40.99 14.49 21 120580 267 29831610
Haemorrhage intracranial 40.67 14.49 6 120595 15026 29816851
Coagulopathy 40.55 14.49 12 120589 18475 29813402
Suspiciousness 40.36 14.49 23 120578 366 29831511
Monocyte count decreased 40.10 14.49 30 120571 772 29831105
Septic shock 40.10 14.49 127 120474 63480 29768397
Tinnitus 40.06 14.49 8 120593 16080 29815797
Sexual dysfunction 39.95 14.49 80 120521 5921 29825956
Freezing phenomenon 39.95 14.49 44 120557 1892 29829985
Therapeutic product effect decreased 39.84 14.49 35 120566 29041 29802836
Obsessive-compulsive symptom 39.83 14.49 14 120587 62 29831815
Pleurothotonus 39.79 14.49 33 120568 990 29830887
Drug dependence 39.66 14.49 18 120583 21277 29810600
Polydipsia 39.57 14.49 60 120541 3553 29828324
Pulmonary valve incompetence 39.22 14.49 28 120573 669 29831208
Visual acuity reduced 39.21 14.49 8 120593 15838 29816039
Drug eruption 39.14 14.49 11 120590 17515 29814362
Ankle fracture 39.10 14.49 60 120541 3591 29828286
Monocytosis 38.95 14.49 22 120579 344 29831533
Condition aggravated 38.93 14.49 361 120240 137505 29694372
Diverticulitis 38.86 14.49 11 120590 17434 29814443
Angina pectoris 38.70 14.49 37 120564 29481 29802396
Neck pain 38.55 14.49 18 120583 20926 29810951
Diplopia 38.43 14.49 5 120596 13767 29818110
Dysphemia 38.34 14.49 38 120563 1443 29830434
Drug intolerance 38.16 14.49 78 120523 45213 29786664
Waxy flexibility 37.63 14.49 15 120586 100 29831777
Lymphocytosis 37.62 14.49 43 120558 1927 29829950
Candida infection 37.50 14.49 8 120593 15354 29816523
Burning sensation 37.42 14.49 10 120591 16464 29815413
Treatment failure 37.30 14.49 51 120550 34628 29797249
Staphylococcal infection 37.22 14.49 40 120561 30184 29801693
Drug level changed 37.14 14.49 21 120580 329 29831548
Lip swelling 37.12 14.49 4 120597 12740 29819137
Hyponatraemia 37.10 14.49 142 120459 67060 29764817
Left atrial dilatation 37.10 14.49 41 120560 1770 29830107
Arteriosclerosis coronary artery 36.99 14.49 114 120487 11062 29820815
Cataract 36.87 14.49 21 120580 21814 29810063
Jaundice 36.76 14.49 46 120555 32440 29799437
Eosinophilic colitis 36.66 14.49 17 120584 171 29831706
Dementia with Lewy bodies 36.61 14.49 25 120576 555 29831322
Hypersplenism 36.55 14.49 20 120581 293 29831584
Total cholesterol/HDL ratio increased 36.43 14.49 16 120585 140 29831737
Swelling face 36.37 14.49 20 120581 21184 29810693
Blood cholesterol increased 36.30 14.49 150 120451 16820 29815057
Stoma site discharge 36.09 14.49 37 120564 1464 29830413
Upper gastrointestinal haemorrhage 36.04 14.49 22 120579 22006 29809871
Bradykinesia 35.89 14.49 54 120547 3176 29828701
Abdominal pain 35.85 14.49 361 120240 135293 29696584
Fluid overload 35.78 14.49 16 120585 19076 29812801
Dry mouth 35.77 14.49 24 120577 22826 29809051
Learning disability 35.76 14.49 16 120585 147 29831730
Contusion 35.70 14.49 44 120557 31236 29800641
SARS-CoV-2 test positive 35.46 14.49 38 120563 1584 29830293
Peritonitis bacterial 34.64 14.49 3 120598 11375 29820502
Neutrophil count 34.47 14.49 9 120592 9 29831868
Prostatic specific antigen increased 34.37 14.49 4 120597 12000 29819877
Inappropriate affect 34.18 14.49 24 120577 558 29831319
QRS axis abnormal 33.98 14.49 32 120569 1140 29830737
Faecal vomiting 33.95 14.49 22 120579 446 29831431
Gastrointestinal necrosis 33.75 14.49 53 120548 3236 29828641
Lymphocyte percentage increased 33.54 14.49 17 120584 211 29831666
Wrong technique in product usage process 33.32 14.49 46 120555 31109 29800768
Toxic skin eruption 33.28 14.49 3 120598 11012 29820865
Hypoacusis 33.24 14.49 8 120593 14131 29817746
Foetal exposure during pregnancy 33.24 14.49 61 120540 36810 29795067
Angina unstable 33.10 14.49 5 120596 12305 29819572
Lower limb fracture 33.07 14.49 56 120545 3643 29828234
Feeling abnormal 32.58 14.49 118 120483 56638 29775239
Epilepsy 32.50 14.49 164 120437 20005 29811872
Dysarthria 32.32 14.49 222 120379 30268 29801609
Toxic epidermal necrolysis 32.13 14.49 16 120585 17924 29813953
Nasopharyngitis 32.06 14.49 125 120476 58724 29773153
Myelocyte count increased 31.88 14.49 12 120589 67 29831810
Ischaemic stroke 31.51 14.49 13 120588 16262 29815615
Dyspepsia 31.23 14.49 46 120555 30283 29801594
Dysphonia 31.15 14.49 19 120582 19013 29812864
Dysuria 31.04 14.49 27 120574 22514 29809363
Delusion of grandeur 30.96 14.49 19 120582 349 29831528
Haemodialysis 30.95 14.49 4 120597 11069 29820808
Suicidal ideation 30.93 14.49 250 120351 35864 29796013
Bacteraemia 30.83 14.49 12 120589 15548 29816329
Spleen congestion 30.58 14.49 19 120582 357 29831520
Hypoxia 30.54 14.49 95 120506 47759 29784118
Chromaturia 30.41 14.49 9 120592 13856 29818021
Heart rate decreased 30.33 14.49 24 120577 20970 29810907
Encephalopathy 30.18 14.49 52 120549 32153 29799724
Multiple sclerosis relapse 30.17 14.49 4 120597 10858 29821019
Appendicectomy 29.91 14.49 26 120575 833 29831044
Electrocardiogram T wave inversion 29.82 14.49 40 120561 2114 29829763
Nasal congestion 29.74 14.49 19 120582 18547 29813330
Appendicitis 29.67 14.49 72 120529 6072 29825805
Bipolar disorder 29.65 14.49 54 120547 3722 29828155
Myocardial fibrosis 29.60 14.49 24 120577 697 29831180
Posture abnormal 29.54 14.49 37 120564 1827 29830050
Chronic kidney disease 29.53 14.49 68 120533 37770 29794107
Fungal infection 29.52 14.49 9 120592 13591 29818286
Granulocytosis 29.51 14.49 16 120585 230 29831647
Neoplasm progression 29.49 14.49 18 120583 18005 29813872
Electrocardiogram change 29.42 14.49 23 120578 633 29831244
Gastric ulcer 29.41 14.49 12 120589 15109 29816768
Stoma site erythema 29.30 14.49 28 120573 1016 29830861
Presyncope 29.24 14.49 14 120587 16042 29815835
Infection 29.19 14.49 459 120142 77615 29754262
Contraindicated product administered 29.11 14.49 142 120459 17089 29814788
Mania 29.03 14.49 92 120509 9062 29822815
Shock haemorrhagic 28.98 14.49 3 120598 9862 29822015
Gamma-glutamyltransferase increased 28.95 14.49 210 120391 29140 29802737
ECG signs of myocardial ischaemia 28.91 14.49 12 120589 90 29831787
Fibroma 28.90 14.49 17 120584 288 29831589
Blood lactate dehydrogenase decreased 28.72 14.49 15 120586 199 29831678
Drowning 28.70 14.49 19 120582 400 29831477
Restlessness 28.54 14.49 172 120429 22427 29809450
Flatulence 28.43 14.49 19 120582 18110 29813767
Rhinorrhoea 28.41 14.49 25 120576 20729 29811148
Suspected COVID-19 28.29 14.49 17 120584 300 29831577
Blood pressure decreased 28.27 14.49 96 120505 46979 29784898
Viral myocarditis 28.27 14.49 13 120588 128 29831749
Volvulus 28.18 14.49 30 120571 1241 29830636
Dementia 28.13 14.49 112 120489 12349 29819528
Amylase decreased 28.06 14.49 9 120592 28 29831849
Metamyelocyte count increased 28.03 14.49 11 120590 70 29831807
Appendicitis perforated 28.02 14.49 35 120566 1723 29830154
Bone marrow failure 28.00 14.49 48 120553 29737 29802140
Pleural effusion 27.91 14.49 179 120422 73887 29757990
Electrocardiogram QT interval abnormal 27.90 14.49 11 120590 71 29831806
Oxygen saturation decreased 27.89 14.49 86 120515 43354 29788523
Acute respiratory distress syndrome 27.87 14.49 32 120569 23440 29808437
Cardiac failure 27.79 14.49 209 120392 83209 29748668
Delusional disorder, unspecified type 27.58 14.49 24 120577 770 29831107
Aortic dilatation 27.27 14.49 25 120576 860 29831017
Blunted affect 27.15 14.49 16 120585 272 29831605
Delusional perception 27.02 14.49 13 120588 143 29831734
Pulmonary arterial hypertension 26.88 14.49 3 120598 9298 29822579
Malignant catatonia 26.84 14.49 12 120589 110 29831767
Cardio-respiratory arrest 26.77 14.49 129 120472 57177 29774700
Clostridium difficile colitis 26.73 14.49 9 120592 12759 29819118
Depression 26.73 14.49 234 120367 90203 29741674
Renal tubular necrosis 26.72 14.49 14 120587 15237 29816640
Neuralgia 26.49 14.49 5 120596 10461 29821416
Suicidal behaviour 26.47 14.49 30 120571 1332 29830545
Stoma site inflammation 26.40 14.49 21 120580 593 29831284
Bundle branch block left 26.22 14.49 62 120539 5142 29826735
Anion gap increased 26.05 14.49 33 120568 1648 29830229
Urine output decreased 26.05 14.49 4 120597 9725 29822152
Patient restraint 26.00 14.49 11 120590 87 29831790
Prostate cancer 25.99 14.49 35 120566 23922 29807955
Throat cancer 25.91 14.49 23 120578 758 29831119
Hypercalcaemia 25.83 14.49 9 120592 12486 29819391
Brain injury 25.71 14.49 64 120537 5484 29826393
Product prescribing error 25.63 14.49 18 120583 16715 29815162
Water intoxication 25.60 14.49 19 120582 483 29831394
Premature baby 25.50 14.49 18 120583 16673 29815204
Acute myeloid leukaemia 25.49 14.49 21 120580 17985 29813892
Psychotic behaviour 25.46 14.49 19 120582 487 29831390
Blood disorder 25.42 14.49 45 120556 3034 29828843
Polyserositis 25.34 14.49 12 120589 127 29831750
Blindness 25.21 14.49 9 120592 12300 29819577
Chest discomfort 25.16 14.49 96 120505 45384 29786493
Tricuspid valve incompetence 24.95 14.49 84 120517 8539 29823338
Testicular germ cell cancer metastatic 24.92 14.49 10 120591 68 29831809
Mutism 24.86 14.49 22 120579 722 29831155
Cardiomegaly 24.82 14.49 120 120481 14389 29817488
Joint stiffness 24.72 14.49 4 120597 9357 29822520
Pseudophaeochromocytoma 24.69 14.49 7 120594 12 29831865
Hyperglycaemia 24.56 14.49 67 120534 35133 29796744
Pseudomonas infection 24.51 14.49 6 120595 10476 29821401
Rash papular 24.46 14.49 3 120598 8642 29823235
Seminoma 24.39 14.49 14 120587 226 29831651
Hyperprolactinaemia 24.29 14.49 27 120574 1173 29830704
Medication error 24.22 14.49 156 120445 20816 29811061
Clostridium difficile infection 24.14 14.49 17 120584 15766 29816111
Throat irritation 24.10 14.49 3 120598 8545 29823332
Blood creatinine decreased 24.00 14.49 41 120560 2686 29829191
Subacute endocarditis 23.95 14.49 9 120592 50 29831827
Empyema 23.91 14.49 42 120559 2814 29829063
Proteinuria 23.90 14.49 18 120583 16127 29815750
Blood bilirubin increased 23.89 14.49 72 120529 36564 29795313
Blood test abnormal 23.80 14.49 62 120539 5463 29826414
Autism spectrum disorder 23.76 14.49 28 120573 1297 29830580
Red blood cell sedimentation rate increased 23.76 14.49 74 120527 7221 29824656
Conduction disorder 23.67 14.49 34 120567 1917 29829960
Ocular hyperaemia 23.58 14.49 4 120597 9039 29822838
Ventricular fibrillation 23.56 14.49 16 120585 15122 29816755
Intentional product misuse 23.43 14.49 67 120534 34600 29797277
Feeling hot 23.32 14.49 17 120584 15487 29816390
Hypothermia 23.23 14.49 88 120513 9479 29822398
Skin ulcer 23.14 14.49 25 120576 18824 29813053
Red cell distribution width decreased 22.99 14.49 12 120589 159 29831718
Oral pain 22.97 14.49 5 120596 9464 29822413
Enterococcal infection 22.91 14.49 3 120598 8221 29823656
Skin discolouration 22.88 14.49 18 120583 15776 29816101
Colitis ulcerative 22.81 14.49 15 120586 14419 29817458
Systolic dysfunction 22.64 14.49 31 120570 1671 29830206
Sopor 22.61 14.49 96 120505 10895 29820982
Eosinopenia 22.60 14.49 5 120596 0 29831877
Pulmonary hypertension 22.55 14.49 26 120575 19010 29812867
Laparotomy 22.54 14.49 14 120587 263 29831614
Loss of libido 22.49 14.49 34 120567 2008 29829869
Eczema 22.37 14.49 13 120588 13356 29818521
Illusion 22.32 14.49 21 120580 747 29831130
Migraine 22.28 14.49 12 120589 12862 29819015
Intervertebral disc protrusion 22.28 14.49 5 120596 9266 29822611
Postmortem blood drug level increased 22.25 14.49 11 120590 129 29831748
Confusional state 22.21 14.49 705 119896 134129 29697748
Increased appetite 22.15 14.49 61 120540 5556 29826321
Testicular cancer metastatic 22.09 14.49 9 120592 64 29831813
Anuria 22.08 14.49 7 120594 10309 29821568
Heat stroke 21.93 14.49 22 120579 848 29831029
Nervousness 21.90 14.49 10 120591 11778 29820099
Loss of personal independence in daily activities 21.84 14.49 33 120568 21502 29810375
Swollen tongue 21.83 14.49 13 120588 13179 29818698
Electroconvulsive therapy 21.65 14.49 6 120595 9 29831868
Rebound effect 21.63 14.49 29 120572 1532 29830345
Intestinal ischaemia 21.58 14.49 69 120532 6828 29825049
Hepatic steatosis 21.57 14.49 117 120484 14676 29817201
Euphoric mood 21.49 14.49 51 120550 4239 29827638
Nephropathy toxic 21.42 14.49 8 120593 10631 29821246
Drug abuse 21.41 14.49 219 120382 81853 29750024
Therapy non-responder 21.35 14.49 55 120546 29398 29802479
Frequent bowel movements 21.30 14.49 4 120597 8401 29823476
Carditis 21.29 14.49 9 120592 71 29831806
Chronic hepatitis C 21.28 14.49 17 120584 483 29831394
Nightmare 21.28 14.49 11 120590 12065 29819812
Hypoalbuminaemia 21.25 14.49 9 120592 11083 29820794
Amnesia 21.24 14.49 41 120560 24280 29807597
Mean cell haemoglobin increased 21.20 14.49 24 120577 1064 29830813
Excessive masturbation 21.19 14.49 10 120591 105 29831772
Staphylococcal sepsis 21.11 14.49 6 120595 9485 29822392
Unresponsive to stimuli 21.08 14.49 180 120421 26239 29805638
Anticholinergic syndrome 21.07 14.49 21 120580 803 29831074
Haemolytic anaemia 21.06 14.49 7 120594 10003 29821874
Gastric haemorrhage 21.03 14.49 6 120595 9461 29822416
Osteomyelitis 20.93 14.49 17 120584 14664 29817213
Hot flush 20.93 14.49 17 120584 14663 29817214
Purpura 20.91 14.49 7 120594 9960 29821917
Brain neoplasm 20.91 14.49 39 120562 2738 29829139
Tangentiality 20.78 14.49 10 120591 110 29831767
Intellectual disability 20.77 14.49 21 120580 817 29831060
Stoma site reaction 20.75 14.49 13 120588 248 29831629
Pulmonary fibrosis 20.73 14.49 20 120581 15870 29816007
Incoherent 20.68 14.49 49 120552 4069 29827808
Polyneuropathy 20.50 14.49 11 120590 11812 29820065
Neurotoxicity 20.43 14.49 14 120587 13168 29818709
Substance use 20.42 14.49 16 120585 442 29831435
Deafness 20.39 14.49 8 120593 10317 29821560
Hypertension 20.28 14.49 355 120246 120999 29710878
Crush syndrome 20.24 14.49 8 120593 52 29831825
End stage renal disease 20.04 14.49 3 120598 7432 29824445
Haemorrhoids 20.04 14.49 12 120589 12129 29819748
Gastrooesophageal reflux disease 19.90 14.49 65 120536 32190 29799687
Ideas of reference 19.74 14.49 8 120593 56 29831821
Tension 19.55 14.49 28 120573 1575 29830302
Hyperosmolar state 19.31 14.49 15 120586 409 29831468
Generalised oedema 19.26 14.49 12 120589 11873 29820004
Cholinergic syndrome 19.18 14.49 16 120585 484 29831393
Acne 19.16 14.49 7 120594 9429 29822448
Norepinephrine increased 19.15 14.49 5 120596 5 29831872
Colitis 19.09 14.49 62 120539 30758 29801119
Rib fracture 19.06 14.49 14 120587 12706 29819171
Blood osmolarity decreased 18.64 14.49 17 120584 581 29831296
Atrial flutter 18.60 14.49 18 120583 14263 29817614
Disorientation 18.60 14.49 201 120400 31217 29800660
Eating disorder 18.44 14.49 65 120536 6762 29825115
Skin disorder 18.43 14.49 12 120589 11596 29820281
Brugada syndrome 18.39 14.49 17 120584 591 29831286
Subdural haematoma 18.36 14.49 30 120571 18942 29812935
Cardiac septal hypertrophy 18.36 14.49 12 120589 247 29831630
Incontinence 18.25 14.49 55 120546 5271 29826606
Withdrawal catatonia 18.22 14.49 8 120593 70 29831807
Somnolence neonatal 18.17 14.49 6 120595 21 29831856
Anisocytosis 18.14 14.49 14 120587 378 29831499
Hepatocellular injury 18.13 14.49 48 120553 25423 29806454
Catecholamines urine increased 18.08 14.49 4 120597 0 29831877
Blood cannabinoids 18.08 14.49 4 120597 0 29831877
Oliguria 17.90 14.49 4 120597 7435 29824442
Mean platelet volume increased 17.79 14.49 14 120587 389 29831488
Memory impairment 17.76 14.49 83 120518 37091 29794786
Faeces discoloured 17.68 14.49 18 120583 13928 29817949
Discomfort 17.67 14.49 19 120582 14337 29817540
Face oedema 17.61 14.49 12 120589 11322 29820555
Haematology test abnormal 17.55 14.49 6 120595 24 29831853
Akinesia 17.45 14.49 34 120567 2466 29829411
Large intestine polyp 17.42 14.49 3 120598 6706 29825171
Pulmonary haemorrhage 17.39 14.49 8 120593 9384 29822493
Mean cell volume abnormal 17.39 14.49 12 120589 271 29831606
Pickwickian syndrome 17.38 14.49 8 120593 79 29831798
Lymphadenopathy 17.30 14.49 46 120555 24330 29807547
Drop attacks 17.25 14.49 16 120585 559 29831318
Hepatic encephalopathy 17.23 14.49 19 120582 14173 29817704
Personality change 17.20 14.49 49 120552 4551 29827326
Viral pericarditis 17.17 14.49 6 120595 26 29831851
Alcohol abuse 17.15 14.49 54 120547 5299 29826578
Thought blocking 17.13 14.49 9 120592 121 29831756
Stab wound 17.07 14.49 10 120591 168 29831709
Coprolalia 16.99 14.49 6 120595 27 29831850
Fall 16.98 14.49 895 119706 180977 29650900
Blood sodium increased 16.98 14.49 36 120565 2775 29829102
Wrong patient received product 16.90 14.49 28 120573 1789 29830088
Dyslipidaemia 16.75 14.49 56 120545 5671 29826206
Cerebrovascular accident 16.70 14.49 236 120365 83241 29748636
Acute coronary syndrome 16.67 14.49 18 120583 13555 29818322
Reduced facial expression 16.57 14.49 18 120583 762 29831115
Lymphocyte morphology abnormal 16.56 14.49 15 120586 508 29831369
Cardiac function test abnormal 16.48 14.49 6 120595 30 29831847
Hyperkinesia 16.47 14.49 30 120571 2068 29829809
Leukaemia 16.31 14.49 39 120562 3258 29828619
Retrograde ejaculation 16.10 14.49 12 120589 307 29831570
Rash macular 16.08 14.49 11 120590 10356 29821521
Productive cough 16.07 14.49 64 120537 29889 29801988
Alcohol detoxification 16.06 14.49 7 120594 60 29831817
Duodenal ulcer 16.04 14.49 10 120591 9891 29821986
Skin cancer 16.00 14.49 6 120595 7955 29823922
Liver function test increased 15.98 14.49 13 120588 11203 29820674
Basilar migraine 15.98 14.49 5 120596 14 29831863
Drug level above therapeutic 15.89 14.49 36 120565 2903 29828974
Acidosis 15.88 14.49 11 120590 10290 29821587
Screaming 15.86 14.49 23 120578 1308 29830569
Faecalith 15.85 14.49 4 120597 3 29831874
Alcohol problem 15.80 14.49 8 120593 99 29831778
Intestinal infarction 15.75 14.49 15 120586 542 29831335
Sinus disorder 15.70 14.49 3 120598 6222 29825655
Osteoporosis 15.64 14.49 12 120589 10651 29821226
Antidepressant drug level increased 15.59 14.49 8 120593 102 29831775
Cogwheel rigidity 15.58 14.49 21 120580 1115 29830762
Endotracheal intubation 15.52 14.49 32 120569 2418 29829459
Haematotoxicity 15.50 14.49 3 120598 6167 29825710
Bone disorder 15.49 14.49 4 120597 6737 29825140
Cholangitis 15.48 14.49 6 120595 7796 29824081
White blood cell disorder 15.46 14.49 22 120579 1230 29830647
Blood creatine phosphokinase decreased 15.43 14.49 14 120587 475 29831402
Myopathy 15.42 14.49 12 120589 10574 29821303
Mechanical ventilation 15.39 14.49 26 120575 1688 29830189
Infantile back arching 15.32 14.49 4 120597 4 29831873
Dermatitis bullous 15.27 14.49 3 120598 6101 29825776
Eye disorder 15.26 14.49 6 120595 7728 29824149
Hemiplegia 15.21 14.49 4 120597 6657 29825220
Throat tightness 15.18 14.49 5 120596 7187 29824690
Antisocial behaviour 15.15 14.49 11 120590 270 29831607
Blood cholesterol decreased 15.14 14.49 19 120582 940 29830937
High-grade B-cell lymphoma 15.07 14.49 9 120592 157 29831720
Pancreatitis acute 15.02 14.49 53 120548 25642 29806235
Liver disorder 15.01 14.49 65 120536 29657 29802220
Non-Hodgkin's lymphoma 14.98 14.49 26 120575 1725 29830152
Somatic symptom disorder 14.97 14.49 14 120587 494 29831383
Musculoskeletal chest pain 14.96 14.49 9 120592 9076 29822801
Small cell carcinoma 14.94 14.49 8 120593 112 29831765
Judgement impaired 14.93 14.49 16 120585 667 29831210
Flank pain 14.90 14.49 3 120598 5995 29825882
Hypersensitivity myocarditis 14.87 14.49 7 120594 73 29831804
Blood urea nitrogen/creatinine ratio decreased 14.81 14.49 6 120595 42 29831835
Intrusive thoughts 14.79 14.49 7 120594 74 29831803
Blood albumin increased 14.75 14.49 16 120585 676 29831201
Gastric dilatation 14.72 14.49 14 120587 505 29831372
Failure to thrive 14.70 14.49 7 120594 8047 29823830
Behaviour disorder 14.69 14.49 31 120570 2381 29829496
Transaminases increased 14.66 14.49 47 120554 23410 29808467
Compensatory sweating 14.63 14.49 5 120596 20 29831857
Ultrasound scan abnormal 14.63 14.49 7 120594 76 29831801
Syncope 14.62 14.49 247 120354 84656 29747221
Pharyngeal oedema 14.56 14.49 4 120597 6467 29825410
Acute pulmonary oedema 14.55 14.49 6 120595 7509 29824368

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37887 adrenergic receptor blockaders
CHEBI has role CHEBI:37956 histamine receptor blocker
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopamine blocker
CHEBI has role CHEBI:48876 antimuskarinika
CHEBI has role CHEBI:65191 atypical antipsychotics
CHEBI has role CHEBI:65259 gamma-aminobutyric acid receptor antagonists
CHEBI has role CHEBI:76779 prolyl oligopeptidase (ec 3.4.21.26) inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 8.44 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Transporter Transporter Ki 6.41 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
5-hydroxytryptamine receptor 5A Unclassified ANTAGONIST Ki 5.30 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR

External reference:

IDSource
4019488 VUID
N0000147608 NUI
D00283 KEGG_DRUG
4019488 VANDF
4024939 VANDF
4036908 VANDF
4037056 VANDF
4037345 VANDF
4040180 VANDF
C0009079 UMLSCUI
CHEBI:3766 CHEBI
CHEMBL42 ChEMBL_ID
CHEMBL538973 ChEMBL_ID
DB00363 DRUGBANK_ID
135398737 PUBCHEM_CID
D003024 MESH_DESCRIPTOR_UI
38 IUPHAR_LIGAND_ID
2612 INN_ID
J60AR2IKIC UNII
216102 RXNORM
11496 MMSL
420 MMSL
4484 MMSL
50904 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
96221003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0825 TABLET 25 mg ORAL ANDA 26 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0860 TABLET 100 mg ORAL ANDA 26 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0972 TABLET 50 mg ORAL ANDA 26 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0973 TABLET 200 mg ORAL ANDA 26 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3813 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3815 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7087 TABLET 100 mg ORAL ANDA 27 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7088 TABLET 200 mg ORAL ANDA 27 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7089 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-141 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-142 TABLET 100 mg ORAL ANDA 27 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-101 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA 27 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-102 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA 27 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-104 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA 27 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-105 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA 27 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-106 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA 27 sections