Stem definition | Drug id | CAS RN |
---|---|---|
psychoactive | 722 | 5786-21-0 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.30 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 45.90 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 55 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.60 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 26, 1989 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hospitalisation | 3133.23 | 14.66 | 1661 | 71523 | 61724 | 46551154 |
Granulocytopenia | 2902.66 | 14.66 | 807 | 72377 | 4466 | 46608412 |
Neutrophil count increased | 2573.16 | 14.66 | 932 | 72252 | 13321 | 46599557 |
White blood cell count increased | 2185.78 | 14.66 | 1160 | 72024 | 43059 | 46569819 |
Neutropenia | 2123.82 | 14.66 | 1769 | 71415 | 141435 | 46471443 |
Schizophrenia | 2111.90 | 14.66 | 707 | 72477 | 7861 | 46605017 |
Neutrophilia | 1593.70 | 14.66 | 446 | 72738 | 2531 | 46610347 |
Antipsychotic drug level increased | 1544.97 | 14.66 | 442 | 72742 | 2750 | 46610128 |
Death | 1398.50 | 14.66 | 2134 | 71050 | 333414 | 46279464 |
Psychotic disorder | 1022.68 | 14.66 | 560 | 72624 | 22061 | 46590817 |
Salivary hypersecretion | 980.45 | 14.66 | 372 | 72812 | 6073 | 46606805 |
Neutrophil count decreased | 851.02 | 14.66 | 634 | 72550 | 42792 | 46570086 |
White blood cell count decreased | 825.32 | 14.66 | 946 | 72238 | 111285 | 46501593 |
Differential white blood cell count abnormal | 805.54 | 14.66 | 191 | 72993 | 474 | 46612404 |
Agranulocytosis | 792.46 | 14.66 | 471 | 72713 | 21714 | 46591164 |
Sedation | 750.20 | 14.66 | 460 | 72724 | 22450 | 46590428 |
Mental impairment | 694.93 | 14.66 | 355 | 72829 | 12101 | 46600777 |
Leukopenia | 539.06 | 14.66 | 598 | 72586 | 67745 | 46545133 |
Platelet count increased | 515.98 | 14.66 | 310 | 72874 | 14564 | 46598314 |
Myocarditis | 485.86 | 14.66 | 239 | 72945 | 7500 | 46605378 |
Pain | 422.01 | 14.66 | 114 | 73070 | 476834 | 46136044 |
Nausea | 405.99 | 14.66 | 294 | 72890 | 687160 | 45925718 |
Neuroleptic malignant syndrome | 383.64 | 14.66 | 231 | 72953 | 10891 | 46601987 |
Antipsychotic drug level above therapeutic | 383.17 | 14.66 | 114 | 73070 | 827 | 46612051 |
Arthralgia | 375.85 | 14.66 | 61 | 73123 | 364542 | 46248336 |
Headache | 374.10 | 14.66 | 142 | 73042 | 478210 | 46134668 |
Rheumatoid arthritis | 360.02 | 14.66 | 3 | 73181 | 240212 | 46372666 |
Hallucination, auditory | 349.44 | 14.66 | 215 | 72969 | 10541 | 46602337 |
Rash | 345.08 | 14.66 | 70 | 73114 | 356442 | 46256436 |
Anosognosia | 334.26 | 14.66 | 113 | 73071 | 1292 | 46611586 |
Mental disorder | 330.37 | 14.66 | 277 | 72907 | 22148 | 46590730 |
Fatigue | 329.11 | 14.66 | 284 | 72900 | 608413 | 46004465 |
Treatment noncompliance | 324.48 | 14.66 | 310 | 72874 | 29421 | 46583457 |
Tachycardia | 317.56 | 14.66 | 564 | 72620 | 99058 | 46513820 |
Dystonia | 305.87 | 14.66 | 201 | 72983 | 11056 | 46601822 |
Drug level increased | 301.43 | 14.66 | 242 | 72942 | 18199 | 46594679 |
Disturbance in social behaviour | 296.34 | 14.66 | 109 | 73075 | 1622 | 46611256 |
Electrocardiogram QT prolonged | 294.12 | 14.66 | 382 | 72802 | 50943 | 46561935 |
Catatonia | 293.67 | 14.66 | 135 | 73049 | 3627 | 46609251 |
Blood prolactin abnormal | 292.26 | 14.66 | 100 | 73084 | 1189 | 46611689 |
Delusion | 287.62 | 14.66 | 193 | 72991 | 10995 | 46601883 |
Pruritus | 264.67 | 14.66 | 34 | 73150 | 242318 | 46370560 |
Drug hypersensitivity | 261.99 | 14.66 | 36 | 73148 | 243789 | 46369089 |
C-reactive protein increased | 257.76 | 14.66 | 384 | 72800 | 58206 | 46554672 |
Haemoglobin decreased | 257.11 | 14.66 | 601 | 72583 | 128348 | 46484530 |
Diarrhoea | 245.94 | 14.66 | 311 | 72873 | 559291 | 46053587 |
Sexual dysfunction | 241.61 | 14.66 | 103 | 73081 | 2300 | 46610578 |
Metabolic disorder | 237.52 | 14.66 | 123 | 73061 | 4309 | 46608569 |
Psychiatric decompensation | 230.95 | 14.66 | 81 | 73103 | 1042 | 46611836 |
Leukocytosis | 229.19 | 14.66 | 230 | 72954 | 23168 | 46589710 |
Schizoaffective disorder | 228.67 | 14.66 | 86 | 73098 | 1366 | 46611512 |
Antipsychotic drug level decreased | 227.18 | 14.66 | 53 | 73131 | 119 | 46612759 |
Pain in extremity | 226 | 14.66 | 63 | 73121 | 258617 | 46354261 |
Dyskinesia | 224.15 | 14.66 | 251 | 72933 | 28674 | 46584204 |
Suicide attempt | 211.63 | 14.66 | 339 | 72845 | 54697 | 46558181 |
Pre-existing disease | 207.07 | 14.66 | 49 | 73135 | 120 | 46612758 |
Lower respiratory tract infection | 204.57 | 14.66 | 334 | 72850 | 54755 | 46558123 |
Alopecia | 184.09 | 14.66 | 20 | 73164 | 162394 | 46450484 |
Eosinophil count decreased | 182.39 | 14.66 | 74 | 73110 | 1452 | 46611426 |
Sinus tachycardia | 181.83 | 14.66 | 196 | 72988 | 21453 | 46591425 |
Overdose | 177.20 | 14.66 | 451 | 72733 | 101528 | 46511350 |
Antipsychotic drug level below therapeutic | 174.83 | 14.66 | 48 | 73136 | 250 | 46612628 |
Peripheral swelling | 170.46 | 14.66 | 23 | 73161 | 158048 | 46454830 |
Joint swelling | 168.05 | 14.66 | 29 | 73155 | 166044 | 46446834 |
Eosinophil count increased | 165.46 | 14.66 | 120 | 73064 | 7746 | 46605132 |
Personality change | 165.43 | 14.66 | 103 | 73081 | 5155 | 46607723 |
Sinusitis | 160.58 | 14.66 | 11 | 73173 | 129757 | 46483121 |
Back pain | 159.27 | 14.66 | 65 | 73119 | 209974 | 46402904 |
Drug interaction | 159.15 | 14.66 | 685 | 72499 | 202409 | 46410469 |
Paranoia | 158.30 | 14.66 | 132 | 73052 | 10465 | 46602413 |
Somnolence | 152.33 | 14.66 | 565 | 72619 | 155956 | 46456922 |
Dyspnoea | 143.44 | 14.66 | 379 | 72805 | 515169 | 46097709 |
Extrapyramidal disorder | 143.26 | 14.66 | 128 | 73056 | 11140 | 46601738 |
Urticaria | 140.20 | 14.66 | 12 | 73172 | 117880 | 46494998 |
Abdominal discomfort | 139.19 | 14.66 | 33 | 73151 | 151132 | 46461746 |
Agitation | 136.01 | 14.66 | 281 | 72903 | 55134 | 46557744 |
Erythema | 131.85 | 14.66 | 31 | 73153 | 142789 | 46470089 |
Troponin increased | 130.73 | 14.66 | 104 | 73080 | 7712 | 46605166 |
Swelling | 129.83 | 14.66 | 20 | 73164 | 124491 | 46488387 |
Aspiration | 122.61 | 14.66 | 109 | 73075 | 9422 | 46603456 |
Hypersensitivity | 121.46 | 14.66 | 42 | 73142 | 150279 | 46462599 |
Lung neoplasm malignant | 120.97 | 14.66 | 135 | 73049 | 15354 | 46597524 |
Drug ineffective | 120.56 | 14.66 | 601 | 72583 | 677237 | 45935641 |
Aggression | 118.99 | 14.66 | 162 | 73022 | 22582 | 46590296 |
Monocyte count increased | 117.45 | 14.66 | 82 | 73102 | 4982 | 46607896 |
Drug intolerance | 115.55 | 14.66 | 43 | 73141 | 147006 | 46465872 |
Akathisia | 115.03 | 14.66 | 96 | 73088 | 7618 | 46605260 |
Neoplasm malignant | 113.40 | 14.66 | 161 | 73023 | 23338 | 46589540 |
Lymphocyte count decreased | 112.85 | 14.66 | 168 | 73016 | 25421 | 46587457 |
Coronavirus infection | 112.04 | 14.66 | 64 | 73120 | 2730 | 46610148 |
Psychotic symptom | 111.75 | 14.66 | 45 | 73139 | 865 | 46612013 |
Living in residential institution | 111.43 | 14.66 | 36 | 73148 | 353 | 46612525 |
Chronic obstructive pulmonary disease | 110.72 | 14.66 | 265 | 72919 | 57368 | 46555510 |
General physical condition abnormal | 110.70 | 14.66 | 69 | 73115 | 3459 | 46609419 |
Drooling | 108.95 | 14.66 | 66 | 73118 | 3143 | 46609735 |
Obsessive-compulsive disorder | 106.27 | 14.66 | 65 | 73119 | 3150 | 46609728 |
Hypoaesthesia | 105.44 | 14.66 | 28 | 73156 | 118841 | 46494037 |
Mean cell haemoglobin decreased | 104.33 | 14.66 | 62 | 73122 | 2850 | 46610028 |
Lymphocyte count increased | 104.15 | 14.66 | 61 | 73123 | 2729 | 46610149 |
Refusal of examination | 103.46 | 14.66 | 22 | 73162 | 25 | 46612853 |
Neuropathy peripheral | 103.43 | 14.66 | 11 | 73173 | 90882 | 46521996 |
Nasopharyngitis | 102.36 | 14.66 | 57 | 73127 | 153941 | 46458937 |
Psoriasis | 102.29 | 14.66 | 5 | 73179 | 78599 | 46534279 |
Electroencephalogram abnormal | 101.88 | 14.66 | 67 | 73117 | 3687 | 46609191 |
Intestinal obstruction | 100.69 | 14.66 | 161 | 73023 | 25914 | 46586964 |
Off label use | 100.37 | 14.66 | 286 | 72898 | 379555 | 46233323 |
Choking | 98.34 | 14.66 | 91 | 73093 | 8285 | 46604593 |
Abnormal behaviour | 98.27 | 14.66 | 142 | 73042 | 20916 | 46591962 |
Eosinophilia | 97.69 | 14.66 | 135 | 73049 | 19082 | 46593796 |
Orthostatic hypotension | 97.62 | 14.66 | 154 | 73030 | 24504 | 46588374 |
Abdominal pain upper | 96.26 | 14.66 | 54 | 73130 | 145251 | 46467627 |
Asthenia | 95.44 | 14.66 | 217 | 72967 | 310858 | 46302020 |
Pleurothotonus | 94.67 | 14.66 | 43 | 73141 | 1122 | 46611756 |
Disease progression | 94.40 | 14.66 | 15 | 73169 | 91285 | 46521593 |
Terminal state | 94.08 | 14.66 | 53 | 73131 | 2201 | 46610677 |
Hyperprolactinaemia | 93.66 | 14.66 | 58 | 73126 | 2874 | 46610004 |
Blood creatine phosphokinase increased | 93.40 | 14.66 | 161 | 73023 | 27563 | 46585315 |
Mean cell volume decreased | 92.81 | 14.66 | 54 | 73130 | 2386 | 46610492 |
Arthropathy | 92.03 | 14.66 | 12 | 73172 | 84688 | 46528190 |
Muscle spasms | 91.79 | 14.66 | 39 | 73145 | 123074 | 46489804 |
Breast cancer | 90.35 | 14.66 | 212 | 72972 | 45306 | 46567572 |
Cough | 89.64 | 14.66 | 139 | 73045 | 230110 | 46382768 |
Urinary incontinence | 88.76 | 14.66 | 160 | 73024 | 28370 | 46584508 |
Treatment failure | 88.30 | 14.66 | 19 | 73165 | 93068 | 46519810 |
Generalised tonic-clonic seizure | 88.10 | 14.66 | 155 | 73029 | 26967 | 46585911 |
Delirium | 88.07 | 14.66 | 186 | 72998 | 37042 | 46575836 |
Paraesthesia | 87.87 | 14.66 | 37 | 73147 | 117400 | 46495478 |
Stomatitis | 86.81 | 14.66 | 5 | 73179 | 68292 | 46544586 |
Psychiatric symptom | 84.25 | 14.66 | 64 | 73120 | 4433 | 46608445 |
Myalgia | 84.06 | 14.66 | 44 | 73140 | 123044 | 46489834 |
Pneumonia aspiration | 83.15 | 14.66 | 165 | 73019 | 31440 | 46581438 |
Blood prolactin increased | 82.08 | 14.66 | 54 | 73130 | 2973 | 46609905 |
Metabolic syndrome | 81.60 | 14.66 | 40 | 73144 | 1244 | 46611634 |
Musculoskeletal pain | 81.04 | 14.66 | 8 | 73176 | 70120 | 46542758 |
Myoclonus | 80.85 | 14.66 | 106 | 73078 | 14246 | 46598632 |
Febrile neutropenia | 80.73 | 14.66 | 24 | 73160 | 94603 | 46518275 |
Diabetes mellitus | 80.28 | 14.66 | 215 | 72969 | 49850 | 46563028 |
Dementia | 79.08 | 14.66 | 107 | 73077 | 14823 | 46598055 |
Malignant neoplasm progression | 78.85 | 14.66 | 6 | 73178 | 64920 | 46547958 |
Enuresis | 78.03 | 14.66 | 45 | 73139 | 1955 | 46610923 |
Decreased appetite | 77.36 | 14.66 | 115 | 73069 | 193721 | 46419157 |
Neutrophil count abnormal | 77.08 | 14.66 | 48 | 73136 | 2402 | 46610476 |
Muscle rigidity | 76.38 | 14.66 | 86 | 73098 | 9875 | 46603003 |
Migraine | 75.88 | 14.66 | 10 | 73174 | 70016 | 46542862 |
Flushing | 75.64 | 14.66 | 7 | 73177 | 64607 | 46548271 |
Mean cell haemoglobin concentration decreased | 75.49 | 14.66 | 48 | 73136 | 2492 | 46610386 |
Tardive dyskinesia | 75.40 | 14.66 | 75 | 73109 | 7468 | 46605410 |
Acute kidney injury | 75.17 | 14.66 | 161 | 73023 | 235694 | 46377184 |
Circulatory collapse | 74.71 | 14.66 | 127 | 73057 | 21497 | 46591381 |
Troponin T increased | 74.58 | 14.66 | 34 | 73150 | 895 | 46611983 |
Haemoglobin increased | 73.55 | 14.66 | 48 | 73136 | 2607 | 46610271 |
Sopor | 71.89 | 14.66 | 119 | 73065 | 19709 | 46593169 |
Intentional self-injury | 70.72 | 14.66 | 132 | 73052 | 24034 | 46588844 |
Acute psychosis | 70.29 | 14.66 | 42 | 73142 | 1950 | 46610928 |
Oedema peripheral | 69.48 | 14.66 | 89 | 73095 | 159617 | 46453261 |
Hallucination | 68.79 | 14.66 | 203 | 72981 | 49748 | 46563130 |
Electrocardiogram abnormal | 68.77 | 14.66 | 69 | 73115 | 6943 | 46605935 |
Therapeutic product effect decreased | 68.57 | 14.66 | 22 | 73162 | 82579 | 46530299 |
Anaphylactic reaction | 67.16 | 14.66 | 4 | 73180 | 53108 | 46559770 |
Mutism | 66.57 | 14.66 | 35 | 73149 | 1265 | 46611613 |
Faecaloma | 66.51 | 14.66 | 71 | 73113 | 7681 | 46605197 |
Body temperature increased | 65.64 | 14.66 | 130 | 73054 | 24731 | 46588147 |
Epistaxis | 65.49 | 14.66 | 11 | 73173 | 64294 | 46548584 |
Arthritis | 65.24 | 14.66 | 20 | 73164 | 77296 | 46535582 |
Dyspepsia | 64.88 | 14.66 | 14 | 73170 | 68458 | 46544420 |
Systemic lupus erythematosus | 64.53 | 14.66 | 12 | 73172 | 65168 | 46547710 |
Constipation | 64.23 | 14.66 | 480 | 72704 | 173617 | 46439261 |
Pericardial effusion | 63.19 | 14.66 | 130 | 73054 | 25413 | 46587465 |
Gastrointestinal hypomotility | 63.09 | 14.66 | 32 | 73152 | 1072 | 46611806 |
Haematocrit decreased | 62.84 | 14.66 | 157 | 73027 | 34900 | 46577978 |
Lung cancer metastatic | 62.04 | 14.66 | 42 | 73142 | 2426 | 46610452 |
Mean cell volume increased | 61.21 | 14.66 | 44 | 73140 | 2800 | 46610078 |
Schizoaffective disorder bipolar type | 60.33 | 14.66 | 17 | 73167 | 99 | 46612779 |
Nasal congestion | 59.71 | 14.66 | 4 | 73180 | 48109 | 46564769 |
Pneumonia | 58.47 | 14.66 | 870 | 72314 | 375450 | 46237428 |
Herpes zoster | 58.27 | 14.66 | 17 | 73167 | 67855 | 46545023 |
COVID-19 | 57.55 | 14.66 | 104 | 73080 | 18471 | 46594407 |
Wrong patient received product | 57.11 | 14.66 | 35 | 73149 | 1702 | 46611176 |
Gastrointestinal carcinoma | 57.08 | 14.66 | 31 | 73153 | 1197 | 46611681 |
Monocyte count decreased | 56.74 | 14.66 | 35 | 73149 | 1722 | 46611156 |
Impaired self-care | 56.54 | 14.66 | 35 | 73149 | 1733 | 46611145 |
Sudden death | 56.35 | 14.66 | 72 | 73112 | 9432 | 46603446 |
Refusal of treatment by patient | 56.28 | 14.66 | 55 | 73129 | 5360 | 46607518 |
Suicidal ideation | 55.95 | 14.66 | 205 | 72979 | 56177 | 46556701 |
Obesity | 55.22 | 14.66 | 88 | 73096 | 14118 | 46598760 |
Chest discomfort | 54.95 | 14.66 | 37 | 73147 | 90232 | 46522646 |
Oculogyric crisis | 54.21 | 14.66 | 30 | 73154 | 1203 | 46611675 |
Rash pruritic | 53.93 | 14.66 | 4 | 73180 | 44211 | 46568667 |
Parkinsonism | 53.21 | 14.66 | 64 | 73120 | 7884 | 46604994 |
Ileus paralytic | 52.76 | 14.66 | 48 | 73136 | 4275 | 46608603 |
Blood glucose increased | 52.52 | 14.66 | 238 | 72946 | 71775 | 46541103 |
Posture abnormal | 52.04 | 14.66 | 36 | 73148 | 2154 | 46610724 |
Blister | 51.80 | 14.66 | 5 | 73179 | 44626 | 46568252 |
Plasma cell myeloma | 51.58 | 14.66 | 5 | 73179 | 44473 | 46568405 |
Bronchitis | 51.53 | 14.66 | 54 | 73130 | 105925 | 46506953 |
Red blood cell count decreased | 51.18 | 14.66 | 139 | 73045 | 32484 | 46580394 |
Epilepsy | 50.89 | 14.66 | 114 | 73070 | 23624 | 46589254 |
Mania | 50.39 | 14.66 | 73 | 73111 | 10773 | 46602105 |
Hot flush | 50.18 | 14.66 | 5 | 73179 | 43512 | 46569366 |
Electrocardiogram T wave abnormal | 49.81 | 14.66 | 36 | 73148 | 2310 | 46610568 |
Contusion | 49.17 | 14.66 | 39 | 73145 | 87448 | 46525430 |
Blood urea decreased | 48.62 | 14.66 | 35 | 73149 | 2232 | 46610646 |
Multiple sclerosis relapse | 48.16 | 14.66 | 5 | 73179 | 42120 | 46570758 |
Parkinson's disease | 48.03 | 14.66 | 30 | 73154 | 1509 | 46611369 |
Chills | 47.75 | 14.66 | 48 | 73136 | 95984 | 46516894 |
Intentional product use issue | 47.60 | 14.66 | 12 | 73172 | 52768 | 46560110 |
Hypokalaemia | 47.29 | 14.66 | 41 | 73143 | 87983 | 46524895 |
Platelet count decreased | 47.12 | 14.66 | 293 | 72891 | 99731 | 46513147 |
Overweight | 46.95 | 14.66 | 39 | 73145 | 3074 | 46609804 |
Hypothermia | 46.71 | 14.66 | 75 | 73109 | 12108 | 46600770 |
Dry skin | 46.55 | 14.66 | 5 | 73179 | 41011 | 46571867 |
Blood alkaline phosphatase increased | 46.23 | 14.66 | 152 | 73032 | 39457 | 46573421 |
Impaired healing | 45.75 | 14.66 | 3 | 73181 | 36740 | 46576138 |
Osteoarthritis | 45.64 | 14.66 | 20 | 73164 | 62005 | 46550873 |
Neck pain | 45.42 | 14.66 | 15 | 73169 | 55291 | 46557587 |
Fibromyalgia | 45.34 | 14.66 | 3 | 73181 | 36460 | 46576418 |
Pancreatic fibrosis | 44.85 | 14.66 | 13 | 73171 | 85 | 46612793 |
Psychiatric evaluation | 44.69 | 14.66 | 10 | 73174 | 17 | 46612861 |
Foreign body in gastrointestinal tract | 44.33 | 14.66 | 10 | 73174 | 18 | 46612860 |
Malaise | 44.28 | 14.66 | 747 | 72437 | 330485 | 46282393 |
Ileus | 43.90 | 14.66 | 79 | 73105 | 13985 | 46598893 |
Medication error | 43.87 | 14.66 | 127 | 73057 | 30784 | 46582094 |
Insomnia | 43.55 | 14.66 | 124 | 73060 | 164800 | 46448078 |
Negativism | 43.41 | 14.66 | 18 | 73166 | 374 | 46612504 |
Borderline personality disorder | 43.40 | 14.66 | 22 | 73162 | 736 | 46612142 |
Weight decreased | 43.14 | 14.66 | 177 | 73007 | 210672 | 46402206 |
Confusional state | 43.09 | 14.66 | 411 | 72773 | 159481 | 46453397 |
Megacolon | 43.04 | 14.66 | 29 | 73155 | 1662 | 46611216 |
Myocardial fibrosis | 42.60 | 14.66 | 20 | 73164 | 564 | 46612314 |
Dyspnoea exertional | 42.43 | 14.66 | 13 | 73171 | 50276 | 46562602 |
Wrong product administered | 42.13 | 14.66 | 48 | 73136 | 5582 | 46607296 |
Inappropriate schedule of product administration | 41.82 | 14.66 | 25 | 73159 | 64988 | 46547890 |
Insurance issue | 41.72 | 14.66 | 29 | 73155 | 1749 | 46611129 |
Depressed level of consciousness | 41.47 | 14.66 | 166 | 73018 | 47403 | 46565475 |
Thrombosis | 41.38 | 14.66 | 18 | 73166 | 56051 | 46556827 |
Abdominal pain | 41.13 | 14.66 | 203 | 72981 | 229828 | 46383050 |
Dizziness | 41.08 | 14.66 | 339 | 72845 | 340075 | 46272803 |
Dysgeusia | 41.06 | 14.66 | 7 | 73177 | 40484 | 46572394 |
Visual impairment | 41.03 | 14.66 | 27 | 73157 | 66662 | 46546216 |
Feeling abnormal | 40.94 | 14.66 | 84 | 73100 | 124976 | 46487902 |
Electrocardiogram T wave inversion | 40.89 | 14.66 | 38 | 73146 | 3478 | 46609400 |
Vomiting | 39.68 | 14.66 | 487 | 72697 | 452307 | 46160571 |
Discomfort | 39.49 | 14.66 | 12 | 73172 | 46658 | 46566220 |
Haematochezia | 39.10 | 14.66 | 6 | 73178 | 37487 | 46575391 |
Red blood cell count increased | 38.72 | 14.66 | 31 | 73153 | 2319 | 46610559 |
Central obesity | 38.55 | 14.66 | 21 | 73163 | 816 | 46612062 |
Benign ethnic neutropenia | 38.22 | 14.66 | 7 | 73177 | 0 | 46612878 |
Loss of personal independence in daily activities | 38.19 | 14.66 | 21 | 73163 | 57162 | 46555716 |
Pain in jaw | 38.11 | 14.66 | 7 | 73177 | 38365 | 46574513 |
Cataract | 37.85 | 14.66 | 12 | 73172 | 45403 | 46567475 |
Dysarthria | 37.75 | 14.66 | 137 | 73047 | 37361 | 46575517 |
Oedema | 37.56 | 14.66 | 30 | 73154 | 67041 | 46545837 |
Blood pressure increased | 36.64 | 14.66 | 91 | 73093 | 126575 | 46486303 |
On and off phenomenon | 36.56 | 14.66 | 28 | 73156 | 1963 | 46610915 |
Wound | 36.23 | 14.66 | 11 | 73173 | 42791 | 46570087 |
Red cell distribution width increased | 36.01 | 14.66 | 52 | 73132 | 7652 | 46605226 |
Electroconvulsive therapy | 35.97 | 14.66 | 10 | 73174 | 55 | 46612823 |
Intentional overdose | 35.58 | 14.66 | 198 | 72986 | 64746 | 46548132 |
Bradykinesia | 35.22 | 14.66 | 37 | 73147 | 3929 | 46608949 |
Fluid retention | 35.19 | 14.66 | 18 | 73166 | 51028 | 46561850 |
Urinary tract infection | 35.18 | 14.66 | 512 | 72672 | 219754 | 46393124 |
Burning sensation | 34.83 | 14.66 | 13 | 73171 | 44398 | 46568480 |
Cervix neoplasm | 34.82 | 14.66 | 13 | 73171 | 202 | 46612676 |
International normalised ratio increased | 34.68 | 14.66 | 15 | 73169 | 46868 | 46566010 |
Akinesia | 34.55 | 14.66 | 26 | 73158 | 1775 | 46611103 |
Persecutory delusion | 34.42 | 14.66 | 30 | 73154 | 2525 | 46610353 |
Interstitial lung disease | 34.34 | 14.66 | 21 | 73163 | 53928 | 46558950 |
Skin ulcer | 34.30 | 14.66 | 5 | 73179 | 32453 | 46580425 |
Rebound psychosis | 34.28 | 14.66 | 8 | 73176 | 18 | 46612860 |
Social avoidant behaviour | 33.63 | 14.66 | 31 | 73153 | 2808 | 46610070 |
Atrial fibrillation | 33.54 | 14.66 | 70 | 73114 | 103520 | 46509358 |
Type 2 diabetes mellitus | 33.52 | 14.66 | 87 | 73097 | 19788 | 46593090 |
Angioedema | 33.50 | 14.66 | 10 | 73174 | 39332 | 46573546 |
Suicidal behaviour | 33.49 | 14.66 | 29 | 73155 | 2419 | 46610459 |
Rhinorrhoea | 32.57 | 14.66 | 17 | 73167 | 47648 | 46565230 |
Monocytosis | 32.53 | 14.66 | 14 | 73170 | 320 | 46612558 |
Muscular weakness | 32.39 | 14.66 | 59 | 73125 | 91785 | 46521093 |
Product quality issue | 32.35 | 14.66 | 8 | 73176 | 35640 | 46577238 |
Device expulsion | 32.19 | 14.66 | 3 | 73181 | 27539 | 46585339 |
Intestinal strangulation | 32.12 | 14.66 | 10 | 73174 | 86 | 46612792 |
Cardiac steatosis | 31.71 | 14.66 | 9 | 73175 | 54 | 46612824 |
Parotitis | 31.13 | 14.66 | 21 | 73163 | 1206 | 46611672 |
Hyperkalaemia | 30.56 | 14.66 | 21 | 73163 | 50688 | 46562190 |
Granulocytosis | 30.52 | 14.66 | 9 | 73175 | 63 | 46612815 |
Waxy flexibility | 30.51 | 14.66 | 10 | 73174 | 103 | 46612775 |
Abnormal clotting factor | 30.34 | 14.66 | 10 | 73174 | 105 | 46612773 |
Accidental exposure to product | 30.28 | 14.66 | 87 | 73097 | 20994 | 46591884 |
Eye pain | 30.24 | 14.66 | 4 | 73180 | 27936 | 46584942 |
Bipolar disorder | 30.04 | 14.66 | 46 | 73138 | 7131 | 46605747 |
Osteoporosis | 30.02 | 14.66 | 13 | 73171 | 40595 | 46572283 |
Parkinsonism hyperpyrexia syndrome | 30.00 | 14.66 | 11 | 73173 | 162 | 46612716 |
Serositis | 29.94 | 14.66 | 16 | 73168 | 598 | 46612280 |
Cardiomyopathy | 29.87 | 14.66 | 73 | 73111 | 16000 | 46596878 |
Osteonecrosis | 29.57 | 14.66 | 3 | 73181 | 25741 | 46587137 |
Haematocrit increased | 29.48 | 14.66 | 23 | 73161 | 1657 | 46611221 |
Pseudophaeochromocytoma | 29.37 | 14.66 | 9 | 73175 | 73 | 46612805 |
Eosinopenia | 29.13 | 14.66 | 6 | 73178 | 5 | 46612873 |
Drug monitoring procedure incorrectly performed | 29.06 | 14.66 | 10 | 73174 | 121 | 46612757 |
Dehydration | 28.95 | 14.66 | 140 | 73044 | 159400 | 46453478 |
Gastrointestinal haemorrhage | 28.83 | 14.66 | 48 | 73136 | 77325 | 46535553 |
Gastrooesophageal reflux disease | 28.75 | 14.66 | 45 | 73139 | 74299 | 46538579 |
Hypocalcaemia | 28.59 | 14.66 | 4 | 73180 | 26781 | 46586097 |
Suspected COVID-19 | 28.53 | 14.66 | 15 | 73169 | 542 | 46612336 |
Tobacco interaction | 28.30 | 14.66 | 7 | 73177 | 22 | 46612856 |
Oral pain | 28.20 | 14.66 | 3 | 73181 | 24794 | 46588084 |
Swelling face | 28.15 | 14.66 | 25 | 73159 | 53034 | 46559844 |
Cardiac failure congestive | 28.05 | 14.66 | 64 | 73120 | 91686 | 46521192 |
Productive cough | 28.00 | 14.66 | 23 | 73161 | 50692 | 46562186 |
Echocardiogram abnormal | 27.96 | 14.66 | 18 | 73166 | 955 | 46611923 |
Gamma-glutamyltransferase increased | 27.85 | 14.66 | 111 | 73073 | 31629 | 46581249 |
Therapeutic product effect incomplete | 27.74 | 14.66 | 50 | 73134 | 78103 | 46534775 |
Hypertension | 27.71 | 14.66 | 187 | 72997 | 196169 | 46416709 |
Loss of consciousness | 27.55 | 14.66 | 275 | 72909 | 107963 | 46504915 |
Visceral congestion | 27.38 | 14.66 | 12 | 73172 | 287 | 46612591 |
Ankle fracture | 27.30 | 14.66 | 69 | 73115 | 15442 | 46597436 |
Hepatic steatosis | 26.93 | 14.66 | 91 | 73093 | 23951 | 46588927 |
Fluid overload | 26.91 | 14.66 | 5 | 73179 | 27180 | 46585698 |
Seizure | 26.81 | 14.66 | 303 | 72881 | 122751 | 46490127 |
Neutrophil toxic granulation present | 26.80 | 14.66 | 7 | 73177 | 29 | 46612849 |
Body mass index increased | 26.80 | 14.66 | 18 | 73166 | 1026 | 46611852 |
Full blood count abnormal | 26.76 | 14.66 | 21 | 73163 | 1526 | 46611352 |
Stoma site discharge | 26.58 | 14.66 | 23 | 73161 | 1917 | 46610961 |
Affective disorder | 26.25 | 14.66 | 35 | 73149 | 4780 | 46608098 |
Bundle branch block right | 26.22 | 14.66 | 35 | 73149 | 4784 | 46608094 |
Toxicity to various agents | 26.22 | 14.66 | 472 | 72712 | 211294 | 46401584 |
Rash maculo-papular | 25.79 | 14.66 | 6 | 73178 | 27868 | 46585010 |
Swollen tongue | 25.68 | 14.66 | 7 | 73177 | 29225 | 46583653 |
Hyponatraemia | 25.42 | 14.66 | 78 | 73106 | 101254 | 46511624 |
Rash erythematous | 25.39 | 14.66 | 11 | 73173 | 34339 | 46578539 |
Diverticulitis | 25.36 | 14.66 | 10 | 73174 | 33029 | 46579849 |
Dry eye | 25.29 | 14.66 | 8 | 73176 | 30314 | 46582564 |
Influenza B virus test positive | 25.06 | 14.66 | 12 | 73172 | 354 | 46612524 |
Globulin abnormal | 24.95 | 14.66 | 5 | 73179 | 3 | 46612875 |
Subileus | 24.87 | 14.66 | 27 | 73157 | 2976 | 46609902 |
Chemotherapy | 24.79 | 14.66 | 19 | 73165 | 1333 | 46611545 |
Sinus rhythm | 24.64 | 14.66 | 14 | 73170 | 591 | 46612287 |
Miosis | 24.19 | 14.66 | 40 | 73144 | 6617 | 46606261 |
Cardiac arrest | 24.13 | 14.66 | 232 | 72952 | 90167 | 46522711 |
Blood albumin decreased | 24.04 | 14.66 | 61 | 73123 | 13684 | 46599194 |
Pericarditis | 23.72 | 14.66 | 87 | 73097 | 23840 | 46589038 |
Stevens-Johnson syndrome | 23.68 | 14.66 | 4 | 73180 | 23293 | 46589585 |
Parotid gland enlargement | 23.58 | 14.66 | 15 | 73169 | 779 | 46612099 |
Haemoptysis | 23.52 | 14.66 | 6 | 73178 | 26183 | 46586695 |
Eye movement disorder | 23.35 | 14.66 | 33 | 73151 | 4760 | 46608118 |
Vision blurred | 23.24 | 14.66 | 57 | 73127 | 79651 | 46533227 |
Self-injurious ideation | 23.23 | 14.66 | 23 | 73161 | 2277 | 46610601 |
Drug level above therapeutic | 23.07 | 14.66 | 28 | 73156 | 3481 | 46609397 |
Microcytosis | 23.05 | 14.66 | 9 | 73175 | 159 | 46612719 |
Dysphonia | 23.02 | 14.66 | 16 | 73168 | 38398 | 46574480 |
Hepatitis C | 23.01 | 14.66 | 38 | 73146 | 6280 | 46606598 |
Wheezing | 22.93 | 14.66 | 30 | 73154 | 53356 | 46559522 |
Basophil count increased | 22.91 | 14.66 | 15 | 73169 | 819 | 46612059 |
Ovarian cancer | 22.85 | 14.66 | 36 | 73148 | 5719 | 46607159 |
Poor personal hygiene | 22.83 | 14.66 | 11 | 73173 | 329 | 46612549 |
Musculoskeletal stiffness | 22.79 | 14.66 | 78 | 73106 | 97915 | 46514963 |
Malignant catatonia | 22.76 | 14.66 | 6 | 73178 | 26 | 46612852 |
Dysphemia | 22.75 | 14.66 | 23 | 73161 | 2335 | 46610543 |
Body mass index decreased | 22.71 | 14.66 | 11 | 73173 | 333 | 46612545 |
Contraindicated product administered | 22.67 | 14.66 | 58 | 73126 | 79889 | 46532989 |
Fungal infection | 22.55 | 14.66 | 9 | 73175 | 29511 | 46583367 |
Neoplasm progression | 22.32 | 14.66 | 7 | 73177 | 26676 | 46586202 |
Cystitis | 22.29 | 14.66 | 20 | 73164 | 42221 | 46570657 |
Echolalia | 22.21 | 14.66 | 9 | 73175 | 176 | 46612702 |
Gastrointestinal disorder | 22.16 | 14.66 | 37 | 73147 | 59539 | 46553339 |
Bradycardia | 22.13 | 14.66 | 44 | 73140 | 66254 | 46546624 |
Skin exfoliation | 22.13 | 14.66 | 12 | 73172 | 32926 | 46579952 |
Basal cell carcinoma | 22.01 | 14.66 | 3 | 73181 | 20484 | 46592394 |
Neutrophil percentage increased | 21.98 | 14.66 | 24 | 73160 | 2663 | 46610215 |
Intestinal dilatation | 21.96 | 14.66 | 19 | 73165 | 1583 | 46611295 |
Wrong technique in product usage process | 21.95 | 14.66 | 32 | 73152 | 54390 | 46558488 |
Hepatotoxicity | 21.95 | 14.66 | 6 | 73178 | 25003 | 46587875 |
Activated partial thromboplastin time abnormal | 21.93 | 14.66 | 8 | 73176 | 116 | 46612762 |
Poverty of speech | 21.91 | 14.66 | 10 | 73174 | 264 | 46612614 |
Hyperkinesia | 21.88 | 14.66 | 20 | 73164 | 1792 | 46611086 |
Neutrophil count normal | 21.84 | 14.66 | 4 | 73180 | 0 | 46612878 |
Skin discolouration | 21.82 | 14.66 | 12 | 73172 | 32668 | 46580210 |
Laryngeal cancer stage III | 21.82 | 14.66 | 5 | 73179 | 10 | 46612868 |
Flatulence | 21.74 | 14.66 | 9 | 73175 | 28869 | 46584009 |
Polyserositis | 21.56 | 14.66 | 10 | 73174 | 274 | 46612604 |
Pulmonary fibrosis | 21.45 | 14.66 | 3 | 73181 | 20089 | 46592789 |
Palpitations | 21.36 | 14.66 | 77 | 73107 | 95182 | 46517696 |
Hepatic enzyme increased | 21.19 | 14.66 | 62 | 73122 | 81725 | 46531153 |
Cerebral haemorrhage | 21.10 | 14.66 | 9 | 73175 | 28362 | 46584516 |
Liver function test increased | 20.95 | 14.66 | 5 | 73179 | 22821 | 46590057 |
Lung carcinoma cell type unspecified stage III | 20.86 | 14.66 | 6 | 73178 | 38 | 46612840 |
Nephrolithiasis | 20.85 | 14.66 | 13 | 73171 | 33038 | 46579840 |
SARS-CoV-2 test positive | 20.85 | 14.66 | 20 | 73164 | 1905 | 46610973 |
Haematuria | 20.83 | 14.66 | 8 | 73176 | 26850 | 46586028 |
Laparotomy | 20.77 | 14.66 | 8 | 73176 | 136 | 46612742 |
Incontinence | 20.73 | 14.66 | 47 | 73137 | 9815 | 46603063 |
Depression | 20.65 | 14.66 | 169 | 73015 | 169935 | 46442943 |
Vertigo | 20.61 | 14.66 | 31 | 73153 | 52017 | 46560861 |
Cervix cancer metastatic | 20.60 | 14.66 | 6 | 73178 | 40 | 46612838 |
Upper respiratory tract infection | 20.52 | 14.66 | 43 | 73141 | 63513 | 46549365 |
Chest pain | 20.14 | 14.66 | 178 | 73006 | 176146 | 46436732 |
Sciatica | 19.93 | 14.66 | 3 | 73181 | 19017 | 46593861 |
Infection | 19.92 | 14.66 | 307 | 72877 | 133285 | 46479593 |
Nervousness | 19.69 | 14.66 | 10 | 73174 | 28465 | 46584413 |
Brain neoplasm | 19.63 | 14.66 | 27 | 73157 | 3797 | 46609081 |
Sexually inappropriate behaviour | 19.61 | 14.66 | 7 | 73177 | 95 | 46612783 |
Catecholamines urine increased | 19.49 | 14.66 | 5 | 73179 | 19 | 46612859 |
Haematoma | 19.47 | 14.66 | 13 | 73171 | 31859 | 46581019 |
Influenza | 19.46 | 14.66 | 73 | 73111 | 89197 | 46523681 |
Hallucination, visual | 19.44 | 14.66 | 67 | 73117 | 17806 | 46595072 |
Therapy cessation | 19.39 | 14.66 | 88 | 73096 | 26541 | 46586337 |
Life support | 19.23 | 14.66 | 9 | 73175 | 252 | 46612626 |
Dementia with Lewy bodies | 19.16 | 14.66 | 9 | 73175 | 254 | 46612624 |
Blood bicarbonate increased | 19.11 | 14.66 | 13 | 73171 | 757 | 46612121 |
Normal newborn | 19.10 | 14.66 | 34 | 73150 | 5967 | 46606911 |
Product administration error | 19.04 | 14.66 | 71 | 73113 | 19610 | 46593268 |
Pulmonary hypertension | 19.04 | 14.66 | 17 | 73167 | 35976 | 46576902 |
Lip swelling | 18.98 | 14.66 | 8 | 73176 | 25387 | 46587491 |
C-reactive protein abnormal | 18.86 | 14.66 | 5 | 73179 | 21265 | 46591613 |
Eczema eyelids | 18.86 | 14.66 | 7 | 73177 | 107 | 46612771 |
Melaena | 18.83 | 14.66 | 10 | 73174 | 27762 | 46585116 |
Intentional product misuse | 18.73 | 14.66 | 28 | 73156 | 47100 | 46565778 |
Hypoacusis | 18.46 | 14.66 | 5 | 73179 | 20964 | 46591914 |
Toxic epidermal necrolysis | 18.36 | 14.66 | 6 | 73178 | 22272 | 46590606 |
Intestinal pseudo-obstruction | 18.33 | 14.66 | 12 | 73172 | 655 | 46612223 |
Hypochromasia | 18.27 | 14.66 | 9 | 73175 | 283 | 46612595 |
Pancytopenia | 18.26 | 14.66 | 70 | 73114 | 84988 | 46527890 |
Liver function test abnormal | 18.14 | 14.66 | 130 | 73054 | 46357 | 46566521 |
Colitis ulcerative | 18.12 | 14.66 | 3 | 73181 | 17729 | 46595149 |
Persistent depressive disorder | 18.07 | 14.66 | 14 | 73170 | 998 | 46611880 |
Rectal haemorrhage | 18.02 | 14.66 | 20 | 73164 | 38235 | 46574643 |
Imprisonment | 17.96 | 14.66 | 8 | 73176 | 199 | 46612679 |
Coronary artery disease | 17.78 | 14.66 | 16 | 73168 | 33736 | 46579142 |
Vascular encephalopathy | 17.73 | 14.66 | 10 | 73174 | 416 | 46612462 |
Asterixis | 17.69 | 14.66 | 15 | 73169 | 1216 | 46611662 |
Obsessive-compulsive symptom | 17.62 | 14.66 | 5 | 73179 | 30 | 46612848 |
Wrong drug | 17.56 | 14.66 | 7 | 73177 | 131 | 46612747 |
Unresponsive to stimuli | 17.55 | 14.66 | 98 | 73086 | 32076 | 46580802 |
Foreign body | 17.46 | 14.66 | 18 | 73166 | 1870 | 46611008 |
Appendicitis | 17.44 | 14.66 | 34 | 73150 | 6392 | 46606486 |
Condition aggravated | 17.31 | 14.66 | 275 | 72909 | 244777 | 46368101 |
Arteriosclerosis coronary artery | 17.29 | 14.66 | 39 | 73145 | 8117 | 46604761 |
Blood triglycerides increased | 17.28 | 14.66 | 49 | 73135 | 11734 | 46601144 |
Disorientation | 17.27 | 14.66 | 108 | 73076 | 36810 | 46576068 |
Freezing phenomenon | 17.25 | 14.66 | 16 | 73168 | 1461 | 46611417 |
Illness anxiety disorder | 17.08 | 14.66 | 7 | 73177 | 141 | 46612737 |
Osteopenia | 17.05 | 14.66 | 3 | 73181 | 16958 | 46595920 |
White blood cell disorder | 16.99 | 14.66 | 18 | 73166 | 1930 | 46610948 |
Gestational diabetes | 16.98 | 14.66 | 36 | 73148 | 7183 | 46605695 |
Hallucination, olfactory | 16.96 | 14.66 | 8 | 73176 | 228 | 46612650 |
Faeces discoloured | 16.80 | 14.66 | 3 | 73181 | 16784 | 46596094 |
Stupor | 16.80 | 14.66 | 24 | 73160 | 3496 | 46609382 |
Thrombocytosis | 16.77 | 14.66 | 29 | 73155 | 4973 | 46607905 |
Device related infection | 16.76 | 14.66 | 6 | 73178 | 21035 | 46591843 |
Lymphocyte percentage increased | 16.73 | 14.66 | 9 | 73175 | 341 | 46612537 |
Ischaemic stroke | 16.71 | 14.66 | 3 | 73181 | 16719 | 46596159 |
Femur fracture | 16.71 | 14.66 | 20 | 73164 | 36977 | 46575901 |
Coma | 16.69 | 14.66 | 152 | 73032 | 58197 | 46554681 |
Gallbladder cholesterolosis | 16.62 | 14.66 | 12 | 73172 | 769 | 46612109 |
Musculoskeletal chest pain | 16.55 | 14.66 | 4 | 73180 | 18102 | 46594776 |
Cholestasis | 16.39 | 14.66 | 11 | 73173 | 26882 | 46585996 |
Phobic avoidance | 16.38 | 14.66 | 3 | 73181 | 0 | 46612878 |
Myelocyte present | 16.38 | 14.66 | 3 | 73181 | 0 | 46612878 |
Stoma site erythema | 16.37 | 14.66 | 14 | 73170 | 1148 | 46611730 |
Appendicitis perforated | 16.23 | 14.66 | 16 | 73168 | 1575 | 46611303 |
Heart rate increased | 16.20 | 14.66 | 184 | 73000 | 74607 | 46538271 |
Eosinophilic myocarditis | 16.19 | 14.66 | 9 | 73175 | 364 | 46612514 |
Suspiciousness | 16.19 | 14.66 | 9 | 73175 | 364 | 46612514 |
Skin lesion | 16.18 | 14.66 | 11 | 73173 | 26702 | 46586176 |
Sedation complication | 16.16 | 14.66 | 24 | 73160 | 3621 | 46609257 |
Corneal pigmentation | 16.07 | 14.66 | 4 | 73180 | 13 | 46612865 |
Gastrointestinal lymphoma | 15.96 | 14.66 | 5 | 73179 | 44 | 46612834 |
Metamyelocyte count increased | 15.91 | 14.66 | 7 | 73177 | 169 | 46612709 |
Irregular breathing | 15.77 | 14.66 | 8 | 73176 | 268 | 46612610 |
Limb discomfort | 15.74 | 14.66 | 8 | 73176 | 22768 | 46590110 |
Hypoglycaemia | 15.74 | 14.66 | 39 | 73145 | 54310 | 46558568 |
Clostridium difficile infection | 15.66 | 14.66 | 10 | 73174 | 25093 | 46587785 |
Stoma site irritation | 15.61 | 14.66 | 8 | 73176 | 274 | 46612604 |
Glaucoma | 15.61 | 14.66 | 3 | 73181 | 15918 | 46596960 |
Monocyte percentage increased | 15.59 | 14.66 | 13 | 73171 | 1030 | 46611848 |
Haemorrhoids | 15.58 | 14.66 | 5 | 73179 | 18772 | 46594106 |
Localised infection | 15.52 | 14.66 | 9 | 73175 | 23792 | 46589086 |
Gastric lavage | 15.48 | 14.66 | 5 | 73179 | 49 | 46612829 |
Staring | 15.40 | 14.66 | 15 | 73169 | 1455 | 46611423 |
Acne | 15.33 | 14.66 | 6 | 73178 | 19913 | 46592965 |
Metastases to spine | 15.33 | 14.66 | 20 | 73164 | 2674 | 46610204 |
Joint stiffness | 15.33 | 14.66 | 12 | 73172 | 27096 | 46585782 |
Drug dependence | 15.31 | 14.66 | 6 | 73178 | 19895 | 46592983 |
Grandiosity | 15.26 | 14.66 | 7 | 73177 | 187 | 46612691 |
Palliative care | 15.19 | 14.66 | 8 | 73176 | 290 | 46612588 |
Hallucinations, mixed | 15.17 | 14.66 | 24 | 73160 | 3825 | 46609053 |
Nodule | 15.17 | 14.66 | 3 | 73181 | 15602 | 46597276 |
Polydipsia | 15.13 | 14.66 | 22 | 73162 | 3257 | 46609621 |
Neglect of personal appearance | 15.11 | 14.66 | 6 | 73178 | 111 | 46612767 |
Thought blocking | 15.06 | 14.66 | 6 | 73178 | 112 | 46612766 |
Impulsive behaviour | 15.02 | 14.66 | 15 | 73169 | 1500 | 46611378 |
Nuchal rigidity | 14.95 | 14.66 | 10 | 73174 | 566 | 46612312 |
Granulocyte count increased | 14.94 | 14.66 | 8 | 73176 | 300 | 46612578 |
Tooth disorder | 14.93 | 14.66 | 9 | 73175 | 23294 | 46589584 |
Fibroma | 14.77 | 14.66 | 12 | 73172 | 917 | 46611961 |
Alcohol poisoning | 14.75 | 14.66 | 18 | 73166 | 2250 | 46610628 |
Eye disorder | 14.75 | 14.66 | 5 | 73179 | 18136 | 46594742 |
Red blood cell nucleated morphology present | 14.70 | 14.66 | 4 | 73180 | 20 | 46612858 |
Huntington's disease | 14.70 | 14.66 | 4 | 73180 | 20 | 46612858 |
Diplopia | 14.68 | 14.66 | 6 | 73178 | 19399 | 46593479 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hospitalisation | 4436.51 | 14.49 | 2551 | 118050 | 41768 | 29790109 |
Neutrophil count increased | 4201.10 | 14.49 | 1757 | 118844 | 13566 | 29818311 |
Schizophrenia | 3884.73 | 14.49 | 1436 | 119165 | 7612 | 29824265 |
White blood cell count increased | 3668.00 | 14.49 | 2170 | 118431 | 37503 | 29794374 |
Granulocytopenia | 3399.44 | 14.49 | 1181 | 119420 | 5045 | 29826832 |
Neutropenia | 2567.88 | 14.49 | 2859 | 117742 | 125681 | 29706196 |
Differential white blood cell count abnormal | 2321.23 | 14.49 | 615 | 119986 | 689 | 29831188 |
Neutrophilia | 1935.29 | 14.49 | 666 | 119935 | 2741 | 29829136 |
Antipsychotic drug level increased | 1744.43 | 14.49 | 605 | 119996 | 2561 | 29829316 |
Myocarditis | 1585.40 | 14.49 | 784 | 119817 | 9227 | 29822650 |
Psychotic disorder | 1533.77 | 14.49 | 999 | 119602 | 20516 | 29811361 |
Salivary hypersecretion | 1343.81 | 14.49 | 641 | 119960 | 6925 | 29824952 |
Agranulocytosis | 1308.11 | 14.49 | 912 | 119689 | 21030 | 29810847 |
Mental impairment | 1285.89 | 14.49 | 664 | 119937 | 8613 | 29823264 |
Neutrophil count decreased | 1282.67 | 14.49 | 1184 | 119417 | 41270 | 29790607 |
Death | 1200.06 | 14.49 | 3642 | 116959 | 353641 | 29478236 |
White blood cell count decreased | 1136.35 | 14.49 | 1538 | 119063 | 82409 | 29749468 |
Neuroleptic malignant syndrome | 841.65 | 14.49 | 621 | 119980 | 15674 | 29816203 |
Sedation | 798.81 | 14.49 | 603 | 119998 | 15770 | 29816107 |
Tachycardia | 787.57 | 14.49 | 1208 | 119393 | 72531 | 29759346 |
Platelet count increased | 625.03 | 14.49 | 407 | 120194 | 8335 | 29823542 |
Leukopenia | 593.54 | 14.49 | 916 | 119685 | 55243 | 29776634 |
Antipsychotic drug level decreased | 580.83 | 14.49 | 192 | 120409 | 676 | 29831201 |
Eosinophil count increased | 551.65 | 14.49 | 355 | 120246 | 7118 | 29824759 |
Lower respiratory tract infection | 512.54 | 14.49 | 584 | 120017 | 26130 | 29805747 |
Mental disorder | 499.17 | 14.49 | 422 | 120179 | 13027 | 29818850 |
Hallucination, auditory | 493.96 | 14.49 | 368 | 120233 | 9421 | 29822456 |
Antipsychotic drug level below therapeutic | 484.33 | 14.49 | 189 | 120412 | 1183 | 29830694 |
C-reactive protein increased | 461.81 | 14.49 | 711 | 119890 | 42762 | 29789115 |
Troponin increased | 431.39 | 14.49 | 326 | 120275 | 8531 | 29823346 |
Antipsychotic drug level above therapeutic | 426.37 | 14.49 | 161 | 120440 | 909 | 29830968 |
Rash | 421.69 | 14.49 | 125 | 120476 | 191764 | 29640113 |
Acute kidney injury | 405.72 | 14.49 | 307 | 120294 | 273535 | 29558342 |
Treatment noncompliance | 395.54 | 14.49 | 498 | 120103 | 24755 | 29807122 |
Diarrhoea | 384.19 | 14.49 | 470 | 120131 | 333633 | 29498244 |
Fatigue | 381.61 | 14.49 | 439 | 120162 | 320234 | 29511643 |
Nausea | 379.41 | 14.49 | 383 | 120218 | 296574 | 29535303 |
Catatonia | 378.50 | 14.49 | 230 | 120371 | 4150 | 29827727 |
Arthralgia | 368.75 | 14.49 | 54 | 120547 | 135737 | 29696140 |
Pruritus | 363.84 | 14.49 | 30 | 120571 | 118174 | 29713703 |
Blood creatine phosphokinase increased | 343.75 | 14.49 | 626 | 119975 | 43222 | 29788655 |
Leukocytosis | 328.74 | 14.49 | 419 | 120182 | 21083 | 29810794 |
Pain | 324.12 | 14.49 | 145 | 120456 | 172496 | 29659381 |
Delusion | 300.28 | 14.49 | 302 | 120299 | 11687 | 29820190 |
Monocyte count increased | 295.74 | 14.49 | 183 | 120418 | 3415 | 29828462 |
Headache | 293.95 | 14.49 | 186 | 120415 | 182120 | 29649757 |
Sinus tachycardia | 292.27 | 14.49 | 336 | 120265 | 15168 | 29816709 |
Eosinophil count decreased | 287.63 | 14.49 | 124 | 120477 | 1033 | 29830844 |
Febrile neutropenia | 277.00 | 14.49 | 48 | 120553 | 106645 | 29725232 |
Faecaloma | 271.33 | 14.49 | 187 | 120414 | 4218 | 29827659 |
Malignant neoplasm progression | 262.10 | 14.49 | 6 | 120595 | 72281 | 29759596 |
Asthenia | 255.12 | 14.49 | 310 | 120291 | 220980 | 29610897 |
Psychiatric decompensation | 253.62 | 14.49 | 118 | 120483 | 1197 | 29830680 |
Dyspnoea | 250.90 | 14.49 | 613 | 119988 | 332682 | 29499195 |
Pain in extremity | 250.71 | 14.49 | 67 | 120534 | 110154 | 29721723 |
Obsessive-compulsive disorder | 246.17 | 14.49 | 172 | 120429 | 3969 | 29827908 |
Off label use | 236.33 | 14.49 | 401 | 120200 | 248889 | 29582988 |
Neuropathy peripheral | 234.11 | 14.49 | 12 | 120589 | 70463 | 29761414 |
Malaise | 230.56 | 14.49 | 1299 | 119302 | 165663 | 29666214 |
Decreased appetite | 224.10 | 14.49 | 166 | 120435 | 149744 | 29682133 |
Haemoglobin decreased | 222.24 | 14.49 | 979 | 119622 | 113119 | 29718758 |
Hyperkalaemia | 213.82 | 14.49 | 13 | 120588 | 65997 | 29765880 |
Pneumonia aspiration | 201.53 | 14.49 | 460 | 120141 | 37320 | 29794557 |
Disease progression | 200.66 | 14.49 | 39 | 120562 | 79835 | 29752042 |
Atrial fibrillation | 199.29 | 14.49 | 93 | 120508 | 108031 | 29723846 |
Paranoia | 199.12 | 14.49 | 225 | 120376 | 9963 | 29821914 |
Erythema | 194.17 | 14.49 | 38 | 120563 | 77413 | 29754464 |
Pre-existing disease | 193.86 | 14.49 | 51 | 120550 | 54 | 29831823 |
Cardiomyopathy | 191.43 | 14.49 | 269 | 120332 | 14874 | 29817003 |
Lung neoplasm malignant | 190.09 | 14.49 | 268 | 120333 | 14864 | 29817013 |
Peripheral swelling | 189.18 | 14.49 | 15 | 120586 | 61059 | 29770818 |
Mean cell volume decreased | 188.81 | 14.49 | 92 | 120509 | 1043 | 29830834 |
Lymphocyte count increased | 188.15 | 14.49 | 121 | 120480 | 2421 | 29829456 |
Back pain | 186.38 | 14.49 | 90 | 120511 | 102506 | 29729371 |
Drooling | 186.09 | 14.49 | 128 | 120473 | 2877 | 29829000 |
Oedema peripheral | 184.53 | 14.49 | 98 | 120503 | 105734 | 29726143 |
Electrocardiogram QT prolonged | 182.00 | 14.49 | 428 | 120173 | 35407 | 29796470 |
Aggression | 180.09 | 14.49 | 434 | 120167 | 36473 | 29795404 |
Urticaria | 176.10 | 14.49 | 11 | 120590 | 54595 | 29777282 |
Drug hypersensitivity | 168.86 | 14.49 | 35 | 120566 | 68484 | 29763393 |
Plasma cell myeloma | 168.79 | 14.49 | 12 | 120589 | 53450 | 29778427 |
Mean cell haemoglobin decreased | 166.67 | 14.49 | 86 | 120515 | 1111 | 29830766 |
Eosinophilia | 164.26 | 14.49 | 309 | 120292 | 21851 | 29810026 |
Gastrointestinal hypomotility | 160.73 | 14.49 | 79 | 120522 | 914 | 29830963 |
Agitation | 159.65 | 14.49 | 530 | 120071 | 53543 | 29778334 |
Extrapyramidal disorder | 159.64 | 14.49 | 206 | 120395 | 10487 | 29821390 |
Interstitial lung disease | 158.53 | 14.49 | 26 | 120575 | 60171 | 29771706 |
Neoplasm malignant | 158.47 | 14.49 | 269 | 120332 | 17545 | 29814332 |
Abnormal behaviour | 158.25 | 14.49 | 331 | 120270 | 25292 | 29806585 |
Joint swelling | 155.86 | 14.49 | 8 | 120593 | 46938 | 29784939 |
Anosognosia | 155.06 | 14.49 | 69 | 120532 | 625 | 29831252 |
Circulatory collapse | 154.99 | 14.49 | 286 | 120315 | 19928 | 29811949 |
Epistaxis | 153.48 | 14.49 | 17 | 120584 | 52964 | 29778913 |
Body temperature increased | 152.93 | 14.49 | 239 | 120362 | 14541 | 29817336 |
General physical condition abnormal | 151.15 | 14.49 | 119 | 120482 | 3311 | 29828566 |
Obesity | 148.88 | 14.49 | 178 | 120423 | 8377 | 29823500 |
Anaemia | 147.96 | 14.49 | 393 | 120208 | 207599 | 29624278 |
Drug level increased | 147.46 | 14.49 | 265 | 120336 | 18089 | 29813788 |
Schizoaffective disorder | 147.14 | 14.49 | 76 | 120525 | 984 | 29830893 |
Imprisonment | 145.94 | 14.49 | 60 | 120541 | 438 | 29831439 |
Electrocardiogram abnormal | 143.09 | 14.49 | 146 | 120455 | 5746 | 29826131 |
Psychotic symptom | 141.70 | 14.49 | 77 | 120524 | 1112 | 29830765 |
Muscle rigidity | 139.78 | 14.49 | 189 | 120412 | 10072 | 29821805 |
Platelet count decreased | 136.57 | 14.49 | 811 | 119790 | 105318 | 29726559 |
Muscle spasms | 135.40 | 14.49 | 46 | 120555 | 64792 | 29767085 |
International normalised ratio increased | 134.11 | 14.49 | 17 | 120584 | 47722 | 29784155 |
Pericarditis | 130.36 | 14.49 | 167 | 120434 | 8439 | 29823438 |
Enuresis | 130.20 | 14.49 | 84 | 120517 | 1690 | 29830187 |
Left ventricular hypertrophy | 128.41 | 14.49 | 142 | 120459 | 6136 | 29825741 |
Akathisia | 126.78 | 14.49 | 137 | 120464 | 5767 | 29826110 |
Dyskinesia | 125.54 | 14.49 | 274 | 120327 | 21560 | 29810317 |
Hypoaesthesia | 125.04 | 14.49 | 32 | 120569 | 54198 | 29777679 |
Stomatitis | 124.87 | 14.49 | 6 | 120595 | 37273 | 29794604 |
Paraesthesia | 123.47 | 14.49 | 33 | 120568 | 54294 | 29777583 |
Left ventricular dysfunction | 122.85 | 14.49 | 163 | 120438 | 8528 | 29823349 |
Rheumatoid arthritis | 122.46 | 14.49 | 12 | 120589 | 41185 | 29790692 |
Cardiac failure congestive | 120.23 | 14.49 | 98 | 120503 | 84309 | 29747568 |
Heart rate increased | 120.07 | 14.49 | 386 | 120215 | 38335 | 29793542 |
Renal failure | 118.65 | 14.49 | 211 | 120390 | 128755 | 29703122 |
Intestinal obstruction | 118.40 | 14.49 | 248 | 120353 | 18964 | 29812913 |
Persecutory delusion | 118.20 | 14.49 | 85 | 120516 | 2055 | 29829822 |
Red blood cell count decreased | 117.26 | 14.49 | 299 | 120302 | 26022 | 29805855 |
Myalgia | 116.88 | 14.49 | 83 | 120518 | 76584 | 29755293 |
Haemoglobin increased | 115.80 | 14.49 | 95 | 120506 | 2807 | 29829070 |
Aspiration | 115.30 | 14.49 | 175 | 120426 | 10376 | 29821501 |
Myoclonus | 114.42 | 14.49 | 198 | 120403 | 13114 | 29818763 |
Mean cell volume increased | 110.16 | 14.49 | 81 | 120520 | 2029 | 29829848 |
Drug ineffective | 108.98 | 14.49 | 864 | 119737 | 339523 | 29492354 |
Hypersensitivity | 106.59 | 14.49 | 42 | 120559 | 53986 | 29777891 |
Tardive dyskinesia | 106.23 | 14.49 | 116 | 120485 | 4941 | 29826936 |
Psoriasis | 106.18 | 14.49 | 21 | 120580 | 42485 | 29789392 |
Refusal of examination | 105.64 | 14.49 | 24 | 120577 | 3 | 29831874 |
Hepatitis C | 103.95 | 14.49 | 189 | 120412 | 13016 | 29818861 |
Thinking abnormal | 103.27 | 14.49 | 117 | 120484 | 5194 | 29826683 |
Echocardiogram abnormal | 103.10 | 14.49 | 53 | 120548 | 679 | 29831198 |
Mucosal inflammation | 101.83 | 14.49 | 5 | 120596 | 30489 | 29801388 |
Troponin T increased | 101.43 | 14.49 | 66 | 120535 | 1348 | 29830529 |
Anaphylactic reaction | 98.84 | 14.49 | 3 | 120598 | 27979 | 29803898 |
Hypoglycaemia | 98.34 | 14.49 | 41 | 120560 | 50940 | 29780937 |
Lymphocyte count decreased | 98.24 | 14.49 | 229 | 120372 | 18826 | 29813051 |
Injection site pain | 98.02 | 14.49 | 6 | 120595 | 30304 | 29801573 |
Choking | 97.94 | 14.49 | 110 | 120491 | 4836 | 29827041 |
Thrombosis | 97.20 | 14.49 | 25 | 120576 | 42206 | 29789671 |
Body mass index increased | 96.48 | 14.49 | 50 | 120551 | 652 | 29831225 |
Overdose | 95.59 | 14.49 | 624 | 119977 | 83713 | 29748164 |
Dystonia | 94.71 | 14.49 | 153 | 120448 | 9574 | 29822303 |
Haematochezia | 94.17 | 14.49 | 13 | 120588 | 34209 | 29797668 |
Blood prolactin abnormal | 93.94 | 14.49 | 50 | 120551 | 691 | 29831186 |
Pancytopenia | 93.71 | 14.49 | 123 | 120478 | 84929 | 29746948 |
Psychiatric symptom | 93.67 | 14.49 | 90 | 120511 | 3289 | 29828588 |
Chills | 93.40 | 14.49 | 92 | 120509 | 72246 | 29759631 |
Lactic acidosis | 93.00 | 14.49 | 9 | 120592 | 31204 | 29800673 |
Benign ethnic neutropenia | 91.91 | 14.49 | 22 | 120579 | 9 | 29831868 |
Dizziness | 91.85 | 14.49 | 438 | 120163 | 194471 | 29637406 |
Somnolence | 90.94 | 14.49 | 684 | 119917 | 96079 | 29735798 |
Megacolon | 89.66 | 14.49 | 65 | 120536 | 1592 | 29830285 |
Ileus paralytic | 89.34 | 14.49 | 112 | 120489 | 5536 | 29826341 |
Seizure | 88.02 | 14.49 | 688 | 119913 | 97787 | 29734090 |
Gastrointestinal haemorrhage | 87.58 | 14.49 | 125 | 120476 | 83321 | 29748556 |
Bradycardia | 87.32 | 14.49 | 81 | 120520 | 65445 | 29766432 |
Cough | 87.22 | 14.49 | 240 | 120361 | 125402 | 29706475 |
Musculoskeletal pain | 86.93 | 14.49 | 11 | 120590 | 30929 | 29800948 |
Intentional product use issue | 86.93 | 14.49 | 20 | 120581 | 36420 | 29795457 |
Hypokalaemia | 86.64 | 14.49 | 47 | 120554 | 50145 | 29781732 |
Sinusitis | 86.44 | 14.49 | 15 | 120586 | 33330 | 29798547 |
Parkinson's disease | 84.99 | 14.49 | 64 | 120537 | 1664 | 29830213 |
Delirium | 84.55 | 14.49 | 356 | 120245 | 40275 | 29791602 |
Neutrophil count abnormal | 83.80 | 14.49 | 58 | 120543 | 1317 | 29830560 |
Living in residential institution | 80.52 | 14.49 | 31 | 120570 | 186 | 29831691 |
Dysgeusia | 79.93 | 14.49 | 5 | 120596 | 24796 | 29807081 |
Generalised tonic-clonic seizure | 79.82 | 14.49 | 215 | 120386 | 19336 | 29812541 |
Melaena | 79.00 | 14.49 | 17 | 120584 | 32420 | 29799457 |
Coma scale abnormal | 78.98 | 14.49 | 82 | 120519 | 3294 | 29828583 |
Hepatitis C virus test positive | 78.90 | 14.49 | 38 | 120563 | 419 | 29831458 |
Drug reaction with eosinophilia and systemic symptoms | 77.96 | 14.49 | 11 | 120590 | 28477 | 29803400 |
Tobacco interaction | 77 | 14.49 | 24 | 120577 | 66 | 29831811 |
Psychiatric evaluation | 76.82 | 14.49 | 17 | 120584 | 0 | 29831877 |
Mean cell haemoglobin concentration decreased | 76.59 | 14.49 | 49 | 120552 | 971 | 29830906 |
Swelling | 74.25 | 14.49 | 26 | 120575 | 35949 | 29795928 |
Disturbance in social behaviour | 73.50 | 14.49 | 55 | 120546 | 1416 | 29830461 |
Muscular weakness | 73.25 | 14.49 | 89 | 120512 | 63556 | 29768321 |
Oedema | 73.13 | 14.49 | 41 | 120560 | 42952 | 29788925 |
Haematuria | 73.08 | 14.49 | 45 | 120556 | 44789 | 29787088 |
Coronavirus infection | 73.06 | 14.49 | 80 | 120521 | 3418 | 29828459 |
Terminal state | 72.81 | 14.49 | 81 | 120520 | 3523 | 29828354 |
Therapy cessation | 71.65 | 14.49 | 176 | 120425 | 14961 | 29816916 |
Ascites | 70.71 | 14.49 | 28 | 120573 | 35893 | 29795984 |
Blood prolactin increased | 70.68 | 14.49 | 53 | 120548 | 1369 | 29830508 |
Renal impairment | 70.14 | 14.49 | 146 | 120455 | 84038 | 29747839 |
Suicide attempt | 69.82 | 14.49 | 313 | 120288 | 36384 | 29795493 |
Vision blurred | 69.52 | 14.49 | 41 | 120560 | 41775 | 29790102 |
Herpes zoster | 68.37 | 14.49 | 18 | 120583 | 29925 | 29801952 |
Cardiac disorder | 67.63 | 14.49 | 329 | 120272 | 39564 | 29792313 |
Apathy | 67.57 | 14.49 | 103 | 120498 | 6129 | 29825748 |
Colitis ischaemic | 67.55 | 14.49 | 99 | 120502 | 5687 | 29826190 |
Overweight | 67.09 | 14.49 | 52 | 120549 | 1413 | 29830464 |
Constipation | 66.90 | 14.49 | 722 | 119879 | 112184 | 29719693 |
Dehydration | 65.77 | 14.49 | 265 | 120336 | 123274 | 29708603 |
Disinhibition | 65.67 | 14.49 | 58 | 120543 | 1899 | 29829978 |
Therapeutic product effect variable | 65.13 | 14.49 | 50 | 120551 | 1339 | 29830538 |
Acute myocardial infarction | 64.19 | 14.49 | 71 | 120530 | 52868 | 29779009 |
Angioedema | 64.16 | 14.49 | 29 | 120572 | 34355 | 29797522 |
Haematoma | 63.81 | 14.49 | 10 | 120591 | 23943 | 29807934 |
Oculogyric crisis | 63.39 | 14.49 | 49 | 120552 | 1326 | 29830551 |
Haematocrit decreased | 63.09 | 14.49 | 268 | 120333 | 30431 | 29801446 |
Dyspnoea exertional | 62.88 | 14.49 | 32 | 120569 | 35398 | 29796479 |
Sudden death | 62.87 | 14.49 | 170 | 120431 | 15322 | 29816555 |
Congestive cardiomyopathy | 62.83 | 14.49 | 103 | 120498 | 6524 | 29825353 |
Inappropriate schedule of product administration | 61.85 | 14.49 | 42 | 120559 | 39686 | 29792191 |
Intestinal dilatation | 61.48 | 14.49 | 45 | 120556 | 1119 | 29830758 |
Cerebral haemorrhage | 60.96 | 14.49 | 28 | 120573 | 32859 | 29799018 |
Social avoidant behaviour | 60.70 | 14.49 | 66 | 120535 | 2797 | 29829080 |
Blood triglycerides increased | 60.11 | 14.49 | 157 | 120444 | 13860 | 29818017 |
Drug monitoring procedure incorrectly performed | 59.23 | 14.49 | 24 | 120577 | 168 | 29831709 |
Arthritis | 58.99 | 14.49 | 13 | 120588 | 24388 | 29807489 |
Weight decreased | 58.93 | 14.49 | 361 | 120240 | 150560 | 29681317 |
Abdominal pain upper | 58.66 | 14.49 | 101 | 120500 | 62450 | 29769427 |
Ejection fraction decreased | 58.08 | 14.49 | 163 | 120438 | 15012 | 29816865 |
Gastrointestinal carcinoma | 58.03 | 14.49 | 41 | 120560 | 963 | 29830914 |
Viral infection | 58.02 | 14.49 | 163 | 120438 | 15022 | 29816855 |
Coronary artery disease | 57.75 | 14.49 | 69 | 120532 | 49643 | 29782234 |
COVID-19 | 57.00 | 14.49 | 180 | 120421 | 17698 | 29814179 |
Troponin I increased | 56.91 | 14.49 | 52 | 120549 | 1781 | 29830096 |
Full blood count abnormal | 56.91 | 14.49 | 42 | 120559 | 1058 | 29830819 |
Pneumocystis jirovecii pneumonia | 56.55 | 14.49 | 3 | 120598 | 17117 | 29814760 |
Pneumonitis | 56.38 | 14.49 | 20 | 120581 | 27434 | 29804443 |
Abdominal discomfort | 56.38 | 14.49 | 68 | 120533 | 48723 | 29783154 |
Influenza like illness | 56.12 | 14.49 | 228 | 120373 | 25377 | 29806500 |
Haemorrhage | 55.64 | 14.49 | 62 | 120539 | 46017 | 29785860 |
Orthostatic hypotension | 55.35 | 14.49 | 217 | 120384 | 23762 | 29808115 |
Fluid retention | 55.26 | 14.49 | 16 | 120585 | 24982 | 29806895 |
Lung cancer metastatic | 54.87 | 14.49 | 59 | 120542 | 2469 | 29829408 |
Parkinsonism | 54.64 | 14.49 | 102 | 120499 | 7167 | 29824710 |
Rash pruritic | 54.61 | 14.49 | 12 | 120589 | 22560 | 29809317 |
Arthropathy | 54.44 | 14.49 | 9 | 120592 | 20718 | 29811159 |
Impaired self-care | 54.25 | 14.49 | 38 | 120563 | 880 | 29830997 |
Rebound psychosis | 53.99 | 14.49 | 21 | 120580 | 130 | 29831747 |
Alopecia | 53.79 | 14.49 | 7 | 120594 | 19268 | 29812609 |
Intentional self-injury | 53.42 | 14.49 | 147 | 120454 | 13385 | 29818492 |
Wheezing | 53.34 | 14.49 | 29 | 120572 | 30909 | 29800968 |
Cholestasis | 53.29 | 14.49 | 17 | 120584 | 24933 | 29806944 |
Ventricular tachycardia | 53.25 | 14.49 | 15 | 120586 | 23847 | 29808030 |
Rectal haemorrhage | 52.99 | 14.49 | 38 | 120563 | 34901 | 29796976 |
Skin exfoliation | 52.77 | 14.49 | 14 | 120587 | 23158 | 29808719 |
Insomnia | 52.35 | 14.49 | 196 | 120405 | 93140 | 29738737 |
Dry skin | 52.22 | 14.49 | 13 | 120588 | 22441 | 29809436 |
Rash erythematous | 52.22 | 14.49 | 13 | 120588 | 22439 | 29809438 |
Cerebral infarction | 51.18 | 14.49 | 21 | 120580 | 26352 | 29805525 |
Metabolic syndrome | 50.85 | 14.49 | 45 | 120556 | 1477 | 29830400 |
Electrocardiogram T wave abnormal | 50.04 | 14.49 | 43 | 120558 | 1356 | 29830521 |
Metabolic disorder | 49.92 | 14.49 | 67 | 120534 | 3544 | 29828333 |
Rash maculo-papular | 49.72 | 14.49 | 20 | 120581 | 25398 | 29806479 |
Basophil count increased | 49.71 | 14.49 | 26 | 120575 | 346 | 29831531 |
Red blood cell count increased | 49.25 | 14.49 | 43 | 120558 | 1386 | 29830491 |
Hepatic failure | 49.09 | 14.49 | 39 | 120562 | 34004 | 29797873 |
Flushing | 48.90 | 14.49 | 29 | 120572 | 29463 | 29802414 |
Intestinal pseudo-obstruction | 48.86 | 14.49 | 39 | 120562 | 1107 | 29830770 |
Full blood count decreased | 48.25 | 14.49 | 4 | 120597 | 15713 | 29816164 |
Osteoarthritis | 48.12 | 14.49 | 8 | 120593 | 18341 | 29813536 |
Multiple organ dysfunction syndrome | 48.05 | 14.49 | 116 | 120485 | 63371 | 29768506 |
Type 2 diabetes mellitus | 47.96 | 14.49 | 142 | 120459 | 13480 | 29818397 |
Hyperbilirubinaemia | 47.65 | 14.49 | 6 | 120595 | 16936 | 29814941 |
Ventricular hypokinesia | 47.49 | 14.49 | 71 | 120530 | 4152 | 29827725 |
Myelodysplastic syndrome | 47.47 | 14.49 | 9 | 120592 | 18769 | 29813108 |
Blood creatinine increased | 47.36 | 14.49 | 198 | 120403 | 91177 | 29740700 |
Refusal of treatment by patient | 47.18 | 14.49 | 78 | 120523 | 4975 | 29826902 |
Lymphoma | 47.17 | 14.49 | 117 | 120484 | 10004 | 29821873 |
Pericardial effusion | 46.91 | 14.49 | 189 | 120412 | 20955 | 29810922 |
Testis cancer | 46.86 | 14.49 | 28 | 120573 | 489 | 29831388 |
Bronchitis | 46.84 | 14.49 | 53 | 120548 | 39072 | 29792805 |
Oesophageal carcinoma | 46.73 | 14.49 | 61 | 120540 | 3140 | 29828737 |
Blood urea decreased | 46.67 | 14.49 | 36 | 120565 | 971 | 29830906 |
Hypocalcaemia | 46.67 | 14.49 | 14 | 120587 | 21362 | 29810515 |
Skin lesion | 46.46 | 14.49 | 9 | 120592 | 18485 | 29813392 |
Device related infection | 45.56 | 14.49 | 7 | 120594 | 17008 | 29814869 |
Neutrophil count normal | 45.19 | 14.49 | 10 | 120591 | 0 | 29831877 |
Visual impairment | 44.99 | 14.49 | 34 | 120567 | 30404 | 29801473 |
Obsessive thoughts | 44.92 | 14.49 | 30 | 120571 | 641 | 29831236 |
Osteonecrosis | 44.69 | 14.49 | 6 | 120595 | 16129 | 29815748 |
Globulins decreased | 44.39 | 14.49 | 20 | 120581 | 187 | 29831690 |
Blister | 44.33 | 14.49 | 14 | 120587 | 20669 | 29811208 |
Weight increased | 44.30 | 14.49 | 479 | 120122 | 74434 | 29757443 |
Bone pain | 44.28 | 14.49 | 11 | 120590 | 19015 | 29812862 |
Polydipsia psychogenic | 43.88 | 14.49 | 17 | 120584 | 104 | 29831773 |
Hepatic function abnormal | 43.81 | 14.49 | 63 | 120538 | 41882 | 29789995 |
Dilatation ventricular | 43.75 | 14.49 | 54 | 120547 | 2626 | 29829251 |
On and off phenomenon | 43.62 | 14.49 | 56 | 120545 | 2835 | 29829042 |
Waist circumference increased | 43.62 | 14.49 | 29 | 120572 | 615 | 29831262 |
Sedation complication | 43.50 | 14.49 | 32 | 120569 | 802 | 29831075 |
Product quality issue | 43.41 | 14.49 | 11 | 120590 | 18763 | 29813114 |
Respiratory failure | 43.41 | 14.49 | 233 | 120368 | 100409 | 29731468 |
Nephrolithiasis | 43.14 | 14.49 | 23 | 120578 | 24787 | 29807090 |
Deep vein thrombosis | 43.11 | 14.49 | 114 | 120487 | 60387 | 29771490 |
Haemoptysis | 43.08 | 14.49 | 37 | 120564 | 31041 | 29800836 |
Impaired healing | 43.07 | 14.49 | 4 | 120597 | 14336 | 29817541 |
Urinary tract infection | 42.64 | 14.49 | 469 | 120132 | 73190 | 29758687 |
Mean cell haemoglobin concentration increased | 42.51 | 14.49 | 22 | 120579 | 286 | 29831591 |
Disseminated intravascular coagulation | 42.47 | 14.49 | 18 | 120583 | 22153 | 29809724 |
Bundle branch block right | 42.32 | 14.49 | 90 | 120511 | 6952 | 29824925 |
Gout | 42.31 | 14.49 | 9 | 120592 | 17306 | 29814571 |
Electroencephalogram abnormal | 42.29 | 14.49 | 50 | 120551 | 2324 | 29829553 |
Basal cell carcinoma | 42.14 | 14.49 | 7 | 120594 | 16061 | 29815816 |
Urinary incontinence | 42.13 | 14.49 | 157 | 120444 | 16783 | 29815094 |
Red cell distribution width increased | 42.05 | 14.49 | 66 | 120535 | 4028 | 29827849 |
Diabetes mellitus | 41.58 | 14.49 | 300 | 120301 | 41565 | 29790312 |
Hypotension | 41.35 | 14.49 | 564 | 120037 | 200001 | 29631876 |
Hepatotoxicity | 41.25 | 14.49 | 11 | 120590 | 18134 | 29813743 |
Drug-induced liver injury | 41.19 | 14.49 | 17 | 120584 | 21257 | 29810620 |
Hallucination | 41.17 | 14.49 | 338 | 120263 | 48721 | 29783156 |
Acute psychosis | 41.10 | 14.49 | 44 | 120557 | 1832 | 29830045 |
Drug dose titration not performed | 41.02 | 14.49 | 20 | 120581 | 227 | 29831650 |
Delusional disorder, persecutory type | 40.99 | 14.49 | 21 | 120580 | 267 | 29831610 |
Haemorrhage intracranial | 40.67 | 14.49 | 6 | 120595 | 15026 | 29816851 |
Coagulopathy | 40.55 | 14.49 | 12 | 120589 | 18475 | 29813402 |
Suspiciousness | 40.36 | 14.49 | 23 | 120578 | 366 | 29831511 |
Monocyte count decreased | 40.10 | 14.49 | 30 | 120571 | 772 | 29831105 |
Septic shock | 40.10 | 14.49 | 127 | 120474 | 63480 | 29768397 |
Tinnitus | 40.06 | 14.49 | 8 | 120593 | 16080 | 29815797 |
Sexual dysfunction | 39.95 | 14.49 | 80 | 120521 | 5921 | 29825956 |
Freezing phenomenon | 39.95 | 14.49 | 44 | 120557 | 1892 | 29829985 |
Therapeutic product effect decreased | 39.84 | 14.49 | 35 | 120566 | 29041 | 29802836 |
Obsessive-compulsive symptom | 39.83 | 14.49 | 14 | 120587 | 62 | 29831815 |
Pleurothotonus | 39.79 | 14.49 | 33 | 120568 | 990 | 29830887 |
Drug dependence | 39.66 | 14.49 | 18 | 120583 | 21277 | 29810600 |
Polydipsia | 39.57 | 14.49 | 60 | 120541 | 3553 | 29828324 |
Pulmonary valve incompetence | 39.22 | 14.49 | 28 | 120573 | 669 | 29831208 |
Visual acuity reduced | 39.21 | 14.49 | 8 | 120593 | 15838 | 29816039 |
Drug eruption | 39.14 | 14.49 | 11 | 120590 | 17515 | 29814362 |
Ankle fracture | 39.10 | 14.49 | 60 | 120541 | 3591 | 29828286 |
Monocytosis | 38.95 | 14.49 | 22 | 120579 | 344 | 29831533 |
Condition aggravated | 38.93 | 14.49 | 361 | 120240 | 137505 | 29694372 |
Diverticulitis | 38.86 | 14.49 | 11 | 120590 | 17434 | 29814443 |
Angina pectoris | 38.70 | 14.49 | 37 | 120564 | 29481 | 29802396 |
Neck pain | 38.55 | 14.49 | 18 | 120583 | 20926 | 29810951 |
Diplopia | 38.43 | 14.49 | 5 | 120596 | 13767 | 29818110 |
Dysphemia | 38.34 | 14.49 | 38 | 120563 | 1443 | 29830434 |
Drug intolerance | 38.16 | 14.49 | 78 | 120523 | 45213 | 29786664 |
Waxy flexibility | 37.63 | 14.49 | 15 | 120586 | 100 | 29831777 |
Lymphocytosis | 37.62 | 14.49 | 43 | 120558 | 1927 | 29829950 |
Candida infection | 37.50 | 14.49 | 8 | 120593 | 15354 | 29816523 |
Burning sensation | 37.42 | 14.49 | 10 | 120591 | 16464 | 29815413 |
Treatment failure | 37.30 | 14.49 | 51 | 120550 | 34628 | 29797249 |
Staphylococcal infection | 37.22 | 14.49 | 40 | 120561 | 30184 | 29801693 |
Drug level changed | 37.14 | 14.49 | 21 | 120580 | 329 | 29831548 |
Lip swelling | 37.12 | 14.49 | 4 | 120597 | 12740 | 29819137 |
Hyponatraemia | 37.10 | 14.49 | 142 | 120459 | 67060 | 29764817 |
Left atrial dilatation | 37.10 | 14.49 | 41 | 120560 | 1770 | 29830107 |
Arteriosclerosis coronary artery | 36.99 | 14.49 | 114 | 120487 | 11062 | 29820815 |
Cataract | 36.87 | 14.49 | 21 | 120580 | 21814 | 29810063 |
Jaundice | 36.76 | 14.49 | 46 | 120555 | 32440 | 29799437 |
Eosinophilic colitis | 36.66 | 14.49 | 17 | 120584 | 171 | 29831706 |
Dementia with Lewy bodies | 36.61 | 14.49 | 25 | 120576 | 555 | 29831322 |
Hypersplenism | 36.55 | 14.49 | 20 | 120581 | 293 | 29831584 |
Total cholesterol/HDL ratio increased | 36.43 | 14.49 | 16 | 120585 | 140 | 29831737 |
Swelling face | 36.37 | 14.49 | 20 | 120581 | 21184 | 29810693 |
Blood cholesterol increased | 36.30 | 14.49 | 150 | 120451 | 16820 | 29815057 |
Stoma site discharge | 36.09 | 14.49 | 37 | 120564 | 1464 | 29830413 |
Upper gastrointestinal haemorrhage | 36.04 | 14.49 | 22 | 120579 | 22006 | 29809871 |
Bradykinesia | 35.89 | 14.49 | 54 | 120547 | 3176 | 29828701 |
Abdominal pain | 35.85 | 14.49 | 361 | 120240 | 135293 | 29696584 |
Fluid overload | 35.78 | 14.49 | 16 | 120585 | 19076 | 29812801 |
Dry mouth | 35.77 | 14.49 | 24 | 120577 | 22826 | 29809051 |
Learning disability | 35.76 | 14.49 | 16 | 120585 | 147 | 29831730 |
Contusion | 35.70 | 14.49 | 44 | 120557 | 31236 | 29800641 |
SARS-CoV-2 test positive | 35.46 | 14.49 | 38 | 120563 | 1584 | 29830293 |
Peritonitis bacterial | 34.64 | 14.49 | 3 | 120598 | 11375 | 29820502 |
Neutrophil count | 34.47 | 14.49 | 9 | 120592 | 9 | 29831868 |
Prostatic specific antigen increased | 34.37 | 14.49 | 4 | 120597 | 12000 | 29819877 |
Inappropriate affect | 34.18 | 14.49 | 24 | 120577 | 558 | 29831319 |
QRS axis abnormal | 33.98 | 14.49 | 32 | 120569 | 1140 | 29830737 |
Faecal vomiting | 33.95 | 14.49 | 22 | 120579 | 446 | 29831431 |
Gastrointestinal necrosis | 33.75 | 14.49 | 53 | 120548 | 3236 | 29828641 |
Lymphocyte percentage increased | 33.54 | 14.49 | 17 | 120584 | 211 | 29831666 |
Wrong technique in product usage process | 33.32 | 14.49 | 46 | 120555 | 31109 | 29800768 |
Toxic skin eruption | 33.28 | 14.49 | 3 | 120598 | 11012 | 29820865 |
Hypoacusis | 33.24 | 14.49 | 8 | 120593 | 14131 | 29817746 |
Foetal exposure during pregnancy | 33.24 | 14.49 | 61 | 120540 | 36810 | 29795067 |
Angina unstable | 33.10 | 14.49 | 5 | 120596 | 12305 | 29819572 |
Lower limb fracture | 33.07 | 14.49 | 56 | 120545 | 3643 | 29828234 |
Feeling abnormal | 32.58 | 14.49 | 118 | 120483 | 56638 | 29775239 |
Epilepsy | 32.50 | 14.49 | 164 | 120437 | 20005 | 29811872 |
Dysarthria | 32.32 | 14.49 | 222 | 120379 | 30268 | 29801609 |
Toxic epidermal necrolysis | 32.13 | 14.49 | 16 | 120585 | 17924 | 29813953 |
Nasopharyngitis | 32.06 | 14.49 | 125 | 120476 | 58724 | 29773153 |
Myelocyte count increased | 31.88 | 14.49 | 12 | 120589 | 67 | 29831810 |
Ischaemic stroke | 31.51 | 14.49 | 13 | 120588 | 16262 | 29815615 |
Dyspepsia | 31.23 | 14.49 | 46 | 120555 | 30283 | 29801594 |
Dysphonia | 31.15 | 14.49 | 19 | 120582 | 19013 | 29812864 |
Dysuria | 31.04 | 14.49 | 27 | 120574 | 22514 | 29809363 |
Delusion of grandeur | 30.96 | 14.49 | 19 | 120582 | 349 | 29831528 |
Haemodialysis | 30.95 | 14.49 | 4 | 120597 | 11069 | 29820808 |
Suicidal ideation | 30.93 | 14.49 | 250 | 120351 | 35864 | 29796013 |
Bacteraemia | 30.83 | 14.49 | 12 | 120589 | 15548 | 29816329 |
Spleen congestion | 30.58 | 14.49 | 19 | 120582 | 357 | 29831520 |
Hypoxia | 30.54 | 14.49 | 95 | 120506 | 47759 | 29784118 |
Chromaturia | 30.41 | 14.49 | 9 | 120592 | 13856 | 29818021 |
Heart rate decreased | 30.33 | 14.49 | 24 | 120577 | 20970 | 29810907 |
Encephalopathy | 30.18 | 14.49 | 52 | 120549 | 32153 | 29799724 |
Multiple sclerosis relapse | 30.17 | 14.49 | 4 | 120597 | 10858 | 29821019 |
Appendicectomy | 29.91 | 14.49 | 26 | 120575 | 833 | 29831044 |
Electrocardiogram T wave inversion | 29.82 | 14.49 | 40 | 120561 | 2114 | 29829763 |
Nasal congestion | 29.74 | 14.49 | 19 | 120582 | 18547 | 29813330 |
Appendicitis | 29.67 | 14.49 | 72 | 120529 | 6072 | 29825805 |
Bipolar disorder | 29.65 | 14.49 | 54 | 120547 | 3722 | 29828155 |
Myocardial fibrosis | 29.60 | 14.49 | 24 | 120577 | 697 | 29831180 |
Posture abnormal | 29.54 | 14.49 | 37 | 120564 | 1827 | 29830050 |
Chronic kidney disease | 29.53 | 14.49 | 68 | 120533 | 37770 | 29794107 |
Fungal infection | 29.52 | 14.49 | 9 | 120592 | 13591 | 29818286 |
Granulocytosis | 29.51 | 14.49 | 16 | 120585 | 230 | 29831647 |
Neoplasm progression | 29.49 | 14.49 | 18 | 120583 | 18005 | 29813872 |
Electrocardiogram change | 29.42 | 14.49 | 23 | 120578 | 633 | 29831244 |
Gastric ulcer | 29.41 | 14.49 | 12 | 120589 | 15109 | 29816768 |
Stoma site erythema | 29.30 | 14.49 | 28 | 120573 | 1016 | 29830861 |
Presyncope | 29.24 | 14.49 | 14 | 120587 | 16042 | 29815835 |
Infection | 29.19 | 14.49 | 459 | 120142 | 77615 | 29754262 |
Contraindicated product administered | 29.11 | 14.49 | 142 | 120459 | 17089 | 29814788 |
Mania | 29.03 | 14.49 | 92 | 120509 | 9062 | 29822815 |
Shock haemorrhagic | 28.98 | 14.49 | 3 | 120598 | 9862 | 29822015 |
Gamma-glutamyltransferase increased | 28.95 | 14.49 | 210 | 120391 | 29140 | 29802737 |
ECG signs of myocardial ischaemia | 28.91 | 14.49 | 12 | 120589 | 90 | 29831787 |
Fibroma | 28.90 | 14.49 | 17 | 120584 | 288 | 29831589 |
Blood lactate dehydrogenase decreased | 28.72 | 14.49 | 15 | 120586 | 199 | 29831678 |
Drowning | 28.70 | 14.49 | 19 | 120582 | 400 | 29831477 |
Restlessness | 28.54 | 14.49 | 172 | 120429 | 22427 | 29809450 |
Flatulence | 28.43 | 14.49 | 19 | 120582 | 18110 | 29813767 |
Rhinorrhoea | 28.41 | 14.49 | 25 | 120576 | 20729 | 29811148 |
Suspected COVID-19 | 28.29 | 14.49 | 17 | 120584 | 300 | 29831577 |
Blood pressure decreased | 28.27 | 14.49 | 96 | 120505 | 46979 | 29784898 |
Viral myocarditis | 28.27 | 14.49 | 13 | 120588 | 128 | 29831749 |
Volvulus | 28.18 | 14.49 | 30 | 120571 | 1241 | 29830636 |
Dementia | 28.13 | 14.49 | 112 | 120489 | 12349 | 29819528 |
Amylase decreased | 28.06 | 14.49 | 9 | 120592 | 28 | 29831849 |
Metamyelocyte count increased | 28.03 | 14.49 | 11 | 120590 | 70 | 29831807 |
Appendicitis perforated | 28.02 | 14.49 | 35 | 120566 | 1723 | 29830154 |
Bone marrow failure | 28.00 | 14.49 | 48 | 120553 | 29737 | 29802140 |
Pleural effusion | 27.91 | 14.49 | 179 | 120422 | 73887 | 29757990 |
Electrocardiogram QT interval abnormal | 27.90 | 14.49 | 11 | 120590 | 71 | 29831806 |
Oxygen saturation decreased | 27.89 | 14.49 | 86 | 120515 | 43354 | 29788523 |
Acute respiratory distress syndrome | 27.87 | 14.49 | 32 | 120569 | 23440 | 29808437 |
Cardiac failure | 27.79 | 14.49 | 209 | 120392 | 83209 | 29748668 |
Delusional disorder, unspecified type | 27.58 | 14.49 | 24 | 120577 | 770 | 29831107 |
Aortic dilatation | 27.27 | 14.49 | 25 | 120576 | 860 | 29831017 |
Blunted affect | 27.15 | 14.49 | 16 | 120585 | 272 | 29831605 |
Delusional perception | 27.02 | 14.49 | 13 | 120588 | 143 | 29831734 |
Pulmonary arterial hypertension | 26.88 | 14.49 | 3 | 120598 | 9298 | 29822579 |
Malignant catatonia | 26.84 | 14.49 | 12 | 120589 | 110 | 29831767 |
Cardio-respiratory arrest | 26.77 | 14.49 | 129 | 120472 | 57177 | 29774700 |
Clostridium difficile colitis | 26.73 | 14.49 | 9 | 120592 | 12759 | 29819118 |
Depression | 26.73 | 14.49 | 234 | 120367 | 90203 | 29741674 |
Renal tubular necrosis | 26.72 | 14.49 | 14 | 120587 | 15237 | 29816640 |
Neuralgia | 26.49 | 14.49 | 5 | 120596 | 10461 | 29821416 |
Suicidal behaviour | 26.47 | 14.49 | 30 | 120571 | 1332 | 29830545 |
Stoma site inflammation | 26.40 | 14.49 | 21 | 120580 | 593 | 29831284 |
Bundle branch block left | 26.22 | 14.49 | 62 | 120539 | 5142 | 29826735 |
Anion gap increased | 26.05 | 14.49 | 33 | 120568 | 1648 | 29830229 |
Urine output decreased | 26.05 | 14.49 | 4 | 120597 | 9725 | 29822152 |
Patient restraint | 26.00 | 14.49 | 11 | 120590 | 87 | 29831790 |
Prostate cancer | 25.99 | 14.49 | 35 | 120566 | 23922 | 29807955 |
Throat cancer | 25.91 | 14.49 | 23 | 120578 | 758 | 29831119 |
Hypercalcaemia | 25.83 | 14.49 | 9 | 120592 | 12486 | 29819391 |
Brain injury | 25.71 | 14.49 | 64 | 120537 | 5484 | 29826393 |
Product prescribing error | 25.63 | 14.49 | 18 | 120583 | 16715 | 29815162 |
Water intoxication | 25.60 | 14.49 | 19 | 120582 | 483 | 29831394 |
Premature baby | 25.50 | 14.49 | 18 | 120583 | 16673 | 29815204 |
Acute myeloid leukaemia | 25.49 | 14.49 | 21 | 120580 | 17985 | 29813892 |
Psychotic behaviour | 25.46 | 14.49 | 19 | 120582 | 487 | 29831390 |
Blood disorder | 25.42 | 14.49 | 45 | 120556 | 3034 | 29828843 |
Polyserositis | 25.34 | 14.49 | 12 | 120589 | 127 | 29831750 |
Blindness | 25.21 | 14.49 | 9 | 120592 | 12300 | 29819577 |
Chest discomfort | 25.16 | 14.49 | 96 | 120505 | 45384 | 29786493 |
Tricuspid valve incompetence | 24.95 | 14.49 | 84 | 120517 | 8539 | 29823338 |
Testicular germ cell cancer metastatic | 24.92 | 14.49 | 10 | 120591 | 68 | 29831809 |
Mutism | 24.86 | 14.49 | 22 | 120579 | 722 | 29831155 |
Cardiomegaly | 24.82 | 14.49 | 120 | 120481 | 14389 | 29817488 |
Joint stiffness | 24.72 | 14.49 | 4 | 120597 | 9357 | 29822520 |
Pseudophaeochromocytoma | 24.69 | 14.49 | 7 | 120594 | 12 | 29831865 |
Hyperglycaemia | 24.56 | 14.49 | 67 | 120534 | 35133 | 29796744 |
Pseudomonas infection | 24.51 | 14.49 | 6 | 120595 | 10476 | 29821401 |
Rash papular | 24.46 | 14.49 | 3 | 120598 | 8642 | 29823235 |
Seminoma | 24.39 | 14.49 | 14 | 120587 | 226 | 29831651 |
Hyperprolactinaemia | 24.29 | 14.49 | 27 | 120574 | 1173 | 29830704 |
Medication error | 24.22 | 14.49 | 156 | 120445 | 20816 | 29811061 |
Clostridium difficile infection | 24.14 | 14.49 | 17 | 120584 | 15766 | 29816111 |
Throat irritation | 24.10 | 14.49 | 3 | 120598 | 8545 | 29823332 |
Blood creatinine decreased | 24.00 | 14.49 | 41 | 120560 | 2686 | 29829191 |
Subacute endocarditis | 23.95 | 14.49 | 9 | 120592 | 50 | 29831827 |
Empyema | 23.91 | 14.49 | 42 | 120559 | 2814 | 29829063 |
Proteinuria | 23.90 | 14.49 | 18 | 120583 | 16127 | 29815750 |
Blood bilirubin increased | 23.89 | 14.49 | 72 | 120529 | 36564 | 29795313 |
Blood test abnormal | 23.80 | 14.49 | 62 | 120539 | 5463 | 29826414 |
Autism spectrum disorder | 23.76 | 14.49 | 28 | 120573 | 1297 | 29830580 |
Red blood cell sedimentation rate increased | 23.76 | 14.49 | 74 | 120527 | 7221 | 29824656 |
Conduction disorder | 23.67 | 14.49 | 34 | 120567 | 1917 | 29829960 |
Ocular hyperaemia | 23.58 | 14.49 | 4 | 120597 | 9039 | 29822838 |
Ventricular fibrillation | 23.56 | 14.49 | 16 | 120585 | 15122 | 29816755 |
Intentional product misuse | 23.43 | 14.49 | 67 | 120534 | 34600 | 29797277 |
Feeling hot | 23.32 | 14.49 | 17 | 120584 | 15487 | 29816390 |
Hypothermia | 23.23 | 14.49 | 88 | 120513 | 9479 | 29822398 |
Skin ulcer | 23.14 | 14.49 | 25 | 120576 | 18824 | 29813053 |
Red cell distribution width decreased | 22.99 | 14.49 | 12 | 120589 | 159 | 29831718 |
Oral pain | 22.97 | 14.49 | 5 | 120596 | 9464 | 29822413 |
Enterococcal infection | 22.91 | 14.49 | 3 | 120598 | 8221 | 29823656 |
Skin discolouration | 22.88 | 14.49 | 18 | 120583 | 15776 | 29816101 |
Colitis ulcerative | 22.81 | 14.49 | 15 | 120586 | 14419 | 29817458 |
Systolic dysfunction | 22.64 | 14.49 | 31 | 120570 | 1671 | 29830206 |
Sopor | 22.61 | 14.49 | 96 | 120505 | 10895 | 29820982 |
Eosinopenia | 22.60 | 14.49 | 5 | 120596 | 0 | 29831877 |
Pulmonary hypertension | 22.55 | 14.49 | 26 | 120575 | 19010 | 29812867 |
Laparotomy | 22.54 | 14.49 | 14 | 120587 | 263 | 29831614 |
Loss of libido | 22.49 | 14.49 | 34 | 120567 | 2008 | 29829869 |
Eczema | 22.37 | 14.49 | 13 | 120588 | 13356 | 29818521 |
Illusion | 22.32 | 14.49 | 21 | 120580 | 747 | 29831130 |
Migraine | 22.28 | 14.49 | 12 | 120589 | 12862 | 29819015 |
Intervertebral disc protrusion | 22.28 | 14.49 | 5 | 120596 | 9266 | 29822611 |
Postmortem blood drug level increased | 22.25 | 14.49 | 11 | 120590 | 129 | 29831748 |
Confusional state | 22.21 | 14.49 | 705 | 119896 | 134129 | 29697748 |
Increased appetite | 22.15 | 14.49 | 61 | 120540 | 5556 | 29826321 |
Testicular cancer metastatic | 22.09 | 14.49 | 9 | 120592 | 64 | 29831813 |
Anuria | 22.08 | 14.49 | 7 | 120594 | 10309 | 29821568 |
Heat stroke | 21.93 | 14.49 | 22 | 120579 | 848 | 29831029 |
Nervousness | 21.90 | 14.49 | 10 | 120591 | 11778 | 29820099 |
Loss of personal independence in daily activities | 21.84 | 14.49 | 33 | 120568 | 21502 | 29810375 |
Swollen tongue | 21.83 | 14.49 | 13 | 120588 | 13179 | 29818698 |
Electroconvulsive therapy | 21.65 | 14.49 | 6 | 120595 | 9 | 29831868 |
Rebound effect | 21.63 | 14.49 | 29 | 120572 | 1532 | 29830345 |
Intestinal ischaemia | 21.58 | 14.49 | 69 | 120532 | 6828 | 29825049 |
Hepatic steatosis | 21.57 | 14.49 | 117 | 120484 | 14676 | 29817201 |
Euphoric mood | 21.49 | 14.49 | 51 | 120550 | 4239 | 29827638 |
Nephropathy toxic | 21.42 | 14.49 | 8 | 120593 | 10631 | 29821246 |
Drug abuse | 21.41 | 14.49 | 219 | 120382 | 81853 | 29750024 |
Therapy non-responder | 21.35 | 14.49 | 55 | 120546 | 29398 | 29802479 |
Frequent bowel movements | 21.30 | 14.49 | 4 | 120597 | 8401 | 29823476 |
Carditis | 21.29 | 14.49 | 9 | 120592 | 71 | 29831806 |
Chronic hepatitis C | 21.28 | 14.49 | 17 | 120584 | 483 | 29831394 |
Nightmare | 21.28 | 14.49 | 11 | 120590 | 12065 | 29819812 |
Hypoalbuminaemia | 21.25 | 14.49 | 9 | 120592 | 11083 | 29820794 |
Amnesia | 21.24 | 14.49 | 41 | 120560 | 24280 | 29807597 |
Mean cell haemoglobin increased | 21.20 | 14.49 | 24 | 120577 | 1064 | 29830813 |
Excessive masturbation | 21.19 | 14.49 | 10 | 120591 | 105 | 29831772 |
Staphylococcal sepsis | 21.11 | 14.49 | 6 | 120595 | 9485 | 29822392 |
Unresponsive to stimuli | 21.08 | 14.49 | 180 | 120421 | 26239 | 29805638 |
Anticholinergic syndrome | 21.07 | 14.49 | 21 | 120580 | 803 | 29831074 |
Haemolytic anaemia | 21.06 | 14.49 | 7 | 120594 | 10003 | 29821874 |
Gastric haemorrhage | 21.03 | 14.49 | 6 | 120595 | 9461 | 29822416 |
Osteomyelitis | 20.93 | 14.49 | 17 | 120584 | 14664 | 29817213 |
Hot flush | 20.93 | 14.49 | 17 | 120584 | 14663 | 29817214 |
Purpura | 20.91 | 14.49 | 7 | 120594 | 9960 | 29821917 |
Brain neoplasm | 20.91 | 14.49 | 39 | 120562 | 2738 | 29829139 |
Tangentiality | 20.78 | 14.49 | 10 | 120591 | 110 | 29831767 |
Intellectual disability | 20.77 | 14.49 | 21 | 120580 | 817 | 29831060 |
Stoma site reaction | 20.75 | 14.49 | 13 | 120588 | 248 | 29831629 |
Pulmonary fibrosis | 20.73 | 14.49 | 20 | 120581 | 15870 | 29816007 |
Incoherent | 20.68 | 14.49 | 49 | 120552 | 4069 | 29827808 |
Polyneuropathy | 20.50 | 14.49 | 11 | 120590 | 11812 | 29820065 |
Neurotoxicity | 20.43 | 14.49 | 14 | 120587 | 13168 | 29818709 |
Substance use | 20.42 | 14.49 | 16 | 120585 | 442 | 29831435 |
Deafness | 20.39 | 14.49 | 8 | 120593 | 10317 | 29821560 |
Hypertension | 20.28 | 14.49 | 355 | 120246 | 120999 | 29710878 |
Crush syndrome | 20.24 | 14.49 | 8 | 120593 | 52 | 29831825 |
End stage renal disease | 20.04 | 14.49 | 3 | 120598 | 7432 | 29824445 |
Haemorrhoids | 20.04 | 14.49 | 12 | 120589 | 12129 | 29819748 |
Gastrooesophageal reflux disease | 19.90 | 14.49 | 65 | 120536 | 32190 | 29799687 |
Ideas of reference | 19.74 | 14.49 | 8 | 120593 | 56 | 29831821 |
Tension | 19.55 | 14.49 | 28 | 120573 | 1575 | 29830302 |
Hyperosmolar state | 19.31 | 14.49 | 15 | 120586 | 409 | 29831468 |
Generalised oedema | 19.26 | 14.49 | 12 | 120589 | 11873 | 29820004 |
Cholinergic syndrome | 19.18 | 14.49 | 16 | 120585 | 484 | 29831393 |
Acne | 19.16 | 14.49 | 7 | 120594 | 9429 | 29822448 |
Norepinephrine increased | 19.15 | 14.49 | 5 | 120596 | 5 | 29831872 |
Colitis | 19.09 | 14.49 | 62 | 120539 | 30758 | 29801119 |
Rib fracture | 19.06 | 14.49 | 14 | 120587 | 12706 | 29819171 |
Blood osmolarity decreased | 18.64 | 14.49 | 17 | 120584 | 581 | 29831296 |
Atrial flutter | 18.60 | 14.49 | 18 | 120583 | 14263 | 29817614 |
Disorientation | 18.60 | 14.49 | 201 | 120400 | 31217 | 29800660 |
Eating disorder | 18.44 | 14.49 | 65 | 120536 | 6762 | 29825115 |
Skin disorder | 18.43 | 14.49 | 12 | 120589 | 11596 | 29820281 |
Brugada syndrome | 18.39 | 14.49 | 17 | 120584 | 591 | 29831286 |
Cardiac septal hypertrophy | 18.36 | 14.49 | 12 | 120589 | 247 | 29831630 |
Subdural haematoma | 18.36 | 14.49 | 30 | 120571 | 18942 | 29812935 |
Incontinence | 18.25 | 14.49 | 55 | 120546 | 5271 | 29826606 |
Withdrawal catatonia | 18.22 | 14.49 | 8 | 120593 | 70 | 29831807 |
Somnolence neonatal | 18.17 | 14.49 | 6 | 120595 | 21 | 29831856 |
Anisocytosis | 18.14 | 14.49 | 14 | 120587 | 378 | 29831499 |
Hepatocellular injury | 18.13 | 14.49 | 48 | 120553 | 25423 | 29806454 |
Catecholamines urine increased | 18.08 | 14.49 | 4 | 120597 | 0 | 29831877 |
Blood cannabinoids | 18.08 | 14.49 | 4 | 120597 | 0 | 29831877 |
Oliguria | 17.90 | 14.49 | 4 | 120597 | 7435 | 29824442 |
Mean platelet volume increased | 17.79 | 14.49 | 14 | 120587 | 389 | 29831488 |
Memory impairment | 17.76 | 14.49 | 83 | 120518 | 37091 | 29794786 |
Faeces discoloured | 17.68 | 14.49 | 18 | 120583 | 13928 | 29817949 |
Discomfort | 17.67 | 14.49 | 19 | 120582 | 14337 | 29817540 |
Face oedema | 17.61 | 14.49 | 12 | 120589 | 11322 | 29820555 |
Haematology test abnormal | 17.55 | 14.49 | 6 | 120595 | 24 | 29831853 |
Akinesia | 17.45 | 14.49 | 34 | 120567 | 2466 | 29829411 |
Large intestine polyp | 17.42 | 14.49 | 3 | 120598 | 6706 | 29825171 |
Pulmonary haemorrhage | 17.39 | 14.49 | 8 | 120593 | 9384 | 29822493 |
Mean cell volume abnormal | 17.39 | 14.49 | 12 | 120589 | 271 | 29831606 |
Pickwickian syndrome | 17.38 | 14.49 | 8 | 120593 | 79 | 29831798 |
Lymphadenopathy | 17.30 | 14.49 | 46 | 120555 | 24330 | 29807547 |
Drop attacks | 17.25 | 14.49 | 16 | 120585 | 559 | 29831318 |
Hepatic encephalopathy | 17.23 | 14.49 | 19 | 120582 | 14173 | 29817704 |
Personality change | 17.20 | 14.49 | 49 | 120552 | 4551 | 29827326 |
Viral pericarditis | 17.17 | 14.49 | 6 | 120595 | 26 | 29831851 |
Alcohol abuse | 17.15 | 14.49 | 54 | 120547 | 5299 | 29826578 |
Thought blocking | 17.13 | 14.49 | 9 | 120592 | 121 | 29831756 |
Stab wound | 17.07 | 14.49 | 10 | 120591 | 168 | 29831709 |
Coprolalia | 16.99 | 14.49 | 6 | 120595 | 27 | 29831850 |
Fall | 16.98 | 14.49 | 895 | 119706 | 180977 | 29650900 |
Blood sodium increased | 16.98 | 14.49 | 36 | 120565 | 2775 | 29829102 |
Wrong patient received product | 16.90 | 14.49 | 28 | 120573 | 1789 | 29830088 |
Dyslipidaemia | 16.75 | 14.49 | 56 | 120545 | 5671 | 29826206 |
Cerebrovascular accident | 16.70 | 14.49 | 236 | 120365 | 83241 | 29748636 |
Acute coronary syndrome | 16.67 | 14.49 | 18 | 120583 | 13555 | 29818322 |
Reduced facial expression | 16.57 | 14.49 | 18 | 120583 | 762 | 29831115 |
Lymphocyte morphology abnormal | 16.56 | 14.49 | 15 | 120586 | 508 | 29831369 |
Cardiac function test abnormal | 16.48 | 14.49 | 6 | 120595 | 30 | 29831847 |
Hyperkinesia | 16.47 | 14.49 | 30 | 120571 | 2068 | 29829809 |
Leukaemia | 16.31 | 14.49 | 39 | 120562 | 3258 | 29828619 |
Retrograde ejaculation | 16.10 | 14.49 | 12 | 120589 | 307 | 29831570 |
Rash macular | 16.08 | 14.49 | 11 | 120590 | 10356 | 29821521 |
Productive cough | 16.07 | 14.49 | 64 | 120537 | 29889 | 29801988 |
Alcohol detoxification | 16.06 | 14.49 | 7 | 120594 | 60 | 29831817 |
Duodenal ulcer | 16.04 | 14.49 | 10 | 120591 | 9891 | 29821986 |
Skin cancer | 16.00 | 14.49 | 6 | 120595 | 7955 | 29823922 |
Liver function test increased | 15.98 | 14.49 | 13 | 120588 | 11203 | 29820674 |
Basilar migraine | 15.98 | 14.49 | 5 | 120596 | 14 | 29831863 |
Drug level above therapeutic | 15.89 | 14.49 | 36 | 120565 | 2903 | 29828974 |
Acidosis | 15.88 | 14.49 | 11 | 120590 | 10290 | 29821587 |
Screaming | 15.86 | 14.49 | 23 | 120578 | 1308 | 29830569 |
Faecalith | 15.85 | 14.49 | 4 | 120597 | 3 | 29831874 |
Alcohol problem | 15.80 | 14.49 | 8 | 120593 | 99 | 29831778 |
Intestinal infarction | 15.75 | 14.49 | 15 | 120586 | 542 | 29831335 |
Sinus disorder | 15.70 | 14.49 | 3 | 120598 | 6222 | 29825655 |
Osteoporosis | 15.64 | 14.49 | 12 | 120589 | 10651 | 29821226 |
Antidepressant drug level increased | 15.59 | 14.49 | 8 | 120593 | 102 | 29831775 |
Cogwheel rigidity | 15.58 | 14.49 | 21 | 120580 | 1115 | 29830762 |
Endotracheal intubation | 15.52 | 14.49 | 32 | 120569 | 2418 | 29829459 |
Haematotoxicity | 15.50 | 14.49 | 3 | 120598 | 6167 | 29825710 |
Bone disorder | 15.49 | 14.49 | 4 | 120597 | 6737 | 29825140 |
Cholangitis | 15.48 | 14.49 | 6 | 120595 | 7796 | 29824081 |
White blood cell disorder | 15.46 | 14.49 | 22 | 120579 | 1230 | 29830647 |
Blood creatine phosphokinase decreased | 15.43 | 14.49 | 14 | 120587 | 475 | 29831402 |
Myopathy | 15.42 | 14.49 | 12 | 120589 | 10574 | 29821303 |
Mechanical ventilation | 15.39 | 14.49 | 26 | 120575 | 1688 | 29830189 |
Infantile back arching | 15.32 | 14.49 | 4 | 120597 | 4 | 29831873 |
Dermatitis bullous | 15.27 | 14.49 | 3 | 120598 | 6101 | 29825776 |
Eye disorder | 15.26 | 14.49 | 6 | 120595 | 7728 | 29824149 |
Hemiplegia | 15.21 | 14.49 | 4 | 120597 | 6657 | 29825220 |
Throat tightness | 15.18 | 14.49 | 5 | 120596 | 7187 | 29824690 |
Antisocial behaviour | 15.15 | 14.49 | 11 | 120590 | 270 | 29831607 |
Blood cholesterol decreased | 15.14 | 14.49 | 19 | 120582 | 940 | 29830937 |
High-grade B-cell lymphoma | 15.07 | 14.49 | 9 | 120592 | 157 | 29831720 |
Pancreatitis acute | 15.02 | 14.49 | 53 | 120548 | 25642 | 29806235 |
Liver disorder | 15.01 | 14.49 | 65 | 120536 | 29657 | 29802220 |
Non-Hodgkin's lymphoma | 14.98 | 14.49 | 26 | 120575 | 1725 | 29830152 |
Somatic symptom disorder | 14.97 | 14.49 | 14 | 120587 | 494 | 29831383 |
Musculoskeletal chest pain | 14.96 | 14.49 | 9 | 120592 | 9076 | 29822801 |
Small cell carcinoma | 14.94 | 14.49 | 8 | 120593 | 112 | 29831765 |
Judgement impaired | 14.93 | 14.49 | 16 | 120585 | 667 | 29831210 |
Flank pain | 14.90 | 14.49 | 3 | 120598 | 5995 | 29825882 |
Hypersensitivity myocarditis | 14.87 | 14.49 | 7 | 120594 | 73 | 29831804 |
Blood urea nitrogen/creatinine ratio decreased | 14.81 | 14.49 | 6 | 120595 | 42 | 29831835 |
Intrusive thoughts | 14.79 | 14.49 | 7 | 120594 | 74 | 29831803 |
Blood albumin increased | 14.75 | 14.49 | 16 | 120585 | 676 | 29831201 |
Gastric dilatation | 14.72 | 14.49 | 14 | 120587 | 505 | 29831372 |
Failure to thrive | 14.70 | 14.49 | 7 | 120594 | 8047 | 29823830 |
Behaviour disorder | 14.69 | 14.49 | 31 | 120570 | 2381 | 29829496 |
Transaminases increased | 14.66 | 14.49 | 47 | 120554 | 23410 | 29808467 |
Ultrasound scan abnormal | 14.63 | 14.49 | 7 | 120594 | 76 | 29831801 |
Compensatory sweating | 14.63 | 14.49 | 5 | 120596 | 20 | 29831857 |
Syncope | 14.62 | 14.49 | 247 | 120354 | 84656 | 29747221 |
Pharyngeal oedema | 14.56 | 14.49 | 4 | 120597 | 6467 | 29825410 |
Acute pulmonary oedema | 14.55 | 14.49 | 6 | 120595 | 7509 | 29824368 |
Source | Code | Description |
---|---|---|
ATC | N05AH02 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Diazepines, oxazepines, thiazepines and oxepines |
FDA EPC | N0000175430 | Atypical Antipsychotic |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:37887 | adrenergic receptor blockaders |
CHEBI has role | CHEBI:37956 | histamine receptor blocker |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:48561 | dopamine blocker |
CHEBI has role | CHEBI:48876 | antimuskarinika |
CHEBI has role | CHEBI:65191 | atypical antipsychotics |
CHEBI has role | CHEBI:65259 | gamma-aminobutyric acid receptor antagonists |
CHEBI has role | CHEBI:76779 | prolyl oligopeptidase (ec 3.4.21.26) inhibitor |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018756 | GABA Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Treatment-Resistant Schizophrenia | indication | ||
Suicidal Behavior in Schizophrenia | indication | ||
Suicidal Behavior in Schizoaffective Disorder | indication | ||
Bipolar disorder in remission | off-label use | 85248005 | |
Bipolar affective disorder, current episode manic | off-label use | 191618007 | |
Sinus tachycardia | contraindication | 11092001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Lowered convulsive threshold | contraindication | 19260006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Alcohol-induced psychosis | contraindication | 42344001 | DOID:252 |
Fecal impaction | contraindication | 44635007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Drug-induced neutropenia | contraindication | 47318007 | |
Myocarditis | contraindication | 50920009 | DOID:820 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Decreased respiratory function | contraindication | 80954004 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Tardive dyskinesia | contraindication | 102449007 | |
Deep venous thrombosis | contraindication | 128053003 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Primary dilated cardiomyopathy | contraindication | 195021004 | |
Cerebrovascular accident | contraindication | 230690007 | |
Pulmonary thromboembolism | contraindication | 233935004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Syncope | contraindication | 271594007 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Eosinophil count raised | contraindication | 386789004 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Breastfeeding (mother) | contraindication | 413712001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Central nervous system depression | contraindication | 418072004 | |
Gastrointestinal hypomotility | contraindication | 421807004 | |
Uncontrolled Epilepsy | contraindication | ||
Substance Overdose | contraindication | ||
Neoplastic Myeloproliferative Disorders | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.59 | Basic |
pKa2 | 4.17 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 6.86 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 8.30 | WOMBAT-PK | CHEMBL | |||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.59 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 9.20 | WOMBAT-PK | |||||
D(1B) dopamine receptor | GPCR | Ki | 6.59 | WOMBAT-PK | |||||
Alpha-1D adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.70 | IUPHAR | ||||
5-hydroxytryptamine receptor 1F | GPCR | AGONIST | Ki | 6.90 | IUPHAR | ||||
5-hydroxytryptamine receptor 1E | GPCR | AGONIST | Ki | 6.40 | IUPHAR | ||||
5-hydroxytryptamine receptor 1D | GPCR | AGONIST | Ki | 6.40 | IUPHAR | ||||
5-hydroxytryptamine receptor 1B | GPCR | AGONIST | Ki | 6.20 | IUPHAR | ||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.42 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.79 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | EC50 | 7.22 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | ANTAGONIST | Ki | 6.59 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 7.78 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 8.26 | WOMBAT-PK | |||||
D(1A) dopamine receptor | GPCR | Ki | 6.89 | WOMBAT-PK | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.98 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 7.28 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 8.54 | WOMBAT-PK | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.36 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.30 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | IC50 | 8.18 | WOMBAT-PK | |||||
Histamine H4 receptor | GPCR | Ki | 8.23 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 6.82 | WOMBAT-PK | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 8.10 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 7.95 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.05 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.60 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 7.15 | WOMBAT-PK | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | IC50 | 5.20 | WOMBAT-PK | |||||
UDP-glucuronosyltransferase 1-4 | Enzyme | app Km | 4.21 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.83 | WOMBAT-PK | |||||
Adenosine receptor A3 | GPCR | IC50 | 6.81 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.20 | CHEMBL | |||||
5-hydroxytryptamine receptor 5A | GPCR | Ki | 6 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.41 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.78 | PDSP | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.30 | PDSP | |||||
D(4) dopamine receptor | GPCR | ANTAGONIST | Ki | 7.52 | WOMBAT-PK | ||||
Alpha-1B adrenergic receptor | GPCR | Ki | 8.44 | DRUG MATRIX | |||||
D(1A) dopamine receptor | GPCR | Ki | 6.38 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.41 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 8.42 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.16 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 6.74 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 8.20 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 6.38 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 4.59 | CHEMBL | |||||
D(4) dopamine receptor | GPCR | Ki | 8.05 | CHEMBL | |||||
Muscarinic acetylcholine receptor | GPCR | Ki | 7.60 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | IC50 | 6.54 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 6.16 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 6.79 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 8.74 | CHEMBL | |||||
Dopamine receptor | GPCR | Ki | 6.49 | CHEMBL | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 7.49 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 7.24 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.80 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 7.28 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 8.68 | CHEMBL | |||||
Adenylate cyclase | Enzyme | IC50 | 6.85 | CHEMBL | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.34 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 6.33 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 7.66 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | Ki | 6.68 | CHEMBL | |||||
5-hydroxytryptamine receptor 1B | GPCR | IC50 | 5.60 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.41 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 7.37 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 7.72 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 8.54 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 6.60 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | IC50 | 7.55 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 8.52 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 7.47 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.10 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | IC50 | 5.70 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.22 | CHEMBL | |||||
5-hydroxytryptamine receptor 5A | Unclassified | ANTAGONIST | Ki | 5.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 7 | GPCR | ANTAGONIST | Ki | 7.40 | IUPHAR | ||||
Histamine H4 receptor | GPCR | ANTAGONIST | Ki | 5.70 | IUPHAR | ||||
Histamine H4 receptor | GPCR | ANTAGONIST | Ki | 5.50 | IUPHAR | ||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 8.40 | IUPHAR | ||||
Histamine H3 receptor | GPCR | ANTAGONIST | Ki | 5.80 | IUPHAR |
ID | Source |
---|---|
4019488 | VUID |
N0000147608 | NUI |
D00283 | KEGG_DRUG |
4019488 | VANDF |
4024939 | VANDF |
4036908 | VANDF |
4037056 | VANDF |
4037345 | VANDF |
4040180 | VANDF |
C0009079 | UMLSCUI |
CHEBI:3766 | CHEBI |
CHEMBL42 | ChEMBL_ID |
CHEMBL538973 | ChEMBL_ID |
DB00363 | DRUGBANK_ID |
135398737 | PUBCHEM_CID |
D003024 | MESH_DESCRIPTOR_UI |
38 | IUPHAR_LIGAND_ID |
2612 | INN_ID |
J60AR2IKIC | UNII |
216102 | RXNORM |
11496 | MMSL |
420 | MMSL |
4484 | MMSL |
50904 | MMSL |
d00199 | MMSL |
003526 | NDDF |
387568001 | SNOMEDCT_US |
96221003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3010 | TABLET, ORALLY DISINTEGRATING | 100 mg | ORAL | NDA authorized generic | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3011 | TABLET, ORALLY DISINTEGRATING | 12.50 mg | ORAL | NDA authorized generic | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3012 | TABLET, ORALLY DISINTEGRATING | 25 mg | ORAL | NDA authorized generic | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3086 | TABLET, ORALLY DISINTEGRATING | 150 mg | ORAL | NDA authorized generic | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3087 | TABLET, ORALLY DISINTEGRATING | 200 mg | ORAL | NDA authorized generic | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4359 | TABLET | 25 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4404 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4405 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5376 | TABLET, ORALLY DISINTEGRATING | 150 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5377 | TABLET, ORALLY DISINTEGRATING | 200 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5416 | TABLET, ORALLY DISINTEGRATING | 12.50 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5417 | TABLET, ORALLY DISINTEGRATING | 25 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5419 | TABLET, ORALLY DISINTEGRATING | 100 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7772 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0825 | TABLET | 25 mg | ORAL | ANDA | 26 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0860 | TABLET | 100 mg | ORAL | ANDA | 26 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0972 | TABLET | 50 mg | ORAL | ANDA | 26 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0973 | TABLET | 200 mg | ORAL | ANDA | 26 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3813 | TABLET, ORALLY DISINTEGRATING | 25 mg | ORAL | ANDA | 28 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3815 | TABLET, ORALLY DISINTEGRATING | 100 mg | ORAL | ANDA | 28 sections |
CLOZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7087 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
CLOZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7088 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
CLOZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7089 | TABLET | 25 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-141 | TABLET | 25 mg | ORAL | ANDA | 27 sections |
Clozapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-142 | TABLET | 100 mg | ORAL | ANDA | 27 sections |
FazaClo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18860-101 | TABLET, ORALLY DISINTEGRATING | 12.50 mg | ORAL | NDA | 27 sections |
FazaClo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18860-102 | TABLET, ORALLY DISINTEGRATING | 25 mg | ORAL | NDA | 27 sections |
FazaClo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18860-104 | TABLET, ORALLY DISINTEGRATING | 100 mg | ORAL | NDA | 27 sections |
FazaClo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18860-105 | TABLET, ORALLY DISINTEGRATING | 150 mg | ORAL | NDA | 27 sections |
FazaClo | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18860-106 | TABLET, ORALLY DISINTEGRATING | 200 mg | ORAL | NDA | 27 sections |