clozapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.093 High 0.82
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.315 High 0.82
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 38.107 10^-6 cm/s High 0.82
dh-clint Dog hepatocyte intrinsic clearance 26.853 uL/min/10^6 cells High 0.82
dppb Dog plasma protein binding (% unbound) 7.810 % High 0.82
fcs-ppb Fetal calf serum protein binding (% unbound) 16.410 % High 0.82
herg hERG pIC50 5.497 pIC50 High 0.82
hh-clint Human hepatocyte intrinsic clearance 5.768 uL/min/10^6 cells High 0.82
hlm-clint Human liver microsomal intrinsic clearance 17.660 uL/min/mg protein High 0.82
hppb Human plasma protein binding (% unbound) 8.170 % High 0.82
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK2,PDK4 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.521 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.638 High 0.82
mh-clint Mouse hepatocyte intrinsic clearance 129.122 High 0.82
mppb Mouse plasma protein binding (% unbound) 7.390 High 0.82
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.462 High 0.82
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 13.150 % High 0.82
rat-kpuu-brain Rat brain Kpuu 0.791 % High 1
rh-clint Rat hepatocyte intrinsic clearance 145.211 uL/min/10^6 cells High 0.82
rh-fuinc Rat hepatocyte fraction unbound in incubation 34.570 % High 0.82
rppb Rat plasma protein binding (% unbound) 6.640 % High 0.82
solubility-dd Solubility at pH 7.4 in DMSO 250.035 uM High 0.82

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 9042.29 16.96 4810 112957 220094 90290586
Hospitalisation 7469.80 16.96 3531 114236 124569 90386111
Neutrophilia 4498.48 16.96 1120 116647 4658 90506022
Neutrophil count increased 3646.19 16.96 1246 116521 18144 90492536
Death 3495.75 16.96 3585 114182 452966 90057714
Granulocytopenia 2996.59 16.96 830 116937 5611 90505069
White blood cell count increased 2676.25 16.96 1435 116332 65806 90444874
Antipsychotic drug level increased 2265.70 16.96 595 117172 3184 90507496
Salivary hypersecretion 1750.20 16.96 595 117172 8497 90502183
Psychotic disorder 1709.19 16.96 827 116940 30403 90480277
Mental impairment 1606.25 16.96 657 117110 16063 90494617
White blood cell count decreased 1498.24 16.96 1435 116332 165674 90345006
Treatment noncompliance 1471.47 16.96 887 116880 50840 90459840
Neutrophil count decreased 1448.34 16.96 990 116777 70542 90440138
Sedation 1406.40 16.96 840 116927 47331 90463349
Differential white blood cell count abnormal 1351.82 16.96 302 117465 676 90510004
Myocarditis 1259.86 16.96 523 117244 13283 90497397
Agranulocytosis 1131.13 16.96 652 117115 34350 90476330
Dystonia 976.41 16.96 464 117303 16355 90494325
Eosinophil count decreased 957.17 16.96 293 117474 2919 90507761
Dyskinesia 955.60 16.96 594 117173 35940 90474740
Anosognosia 901.53 16.96 286 117481 3236 90507444
Schizoaffective disorder 874.81 16.96 307 117460 4840 90505840
Leukopenia 864.09 16.96 845 116922 99865 90410815
Drug level increased 817.43 16.96 487 117280 27275 90483405
Therapy interrupted 798.82 16.96 600 117167 49508 90461172
Blood prolactin abnormal 798.03 16.96 256 117511 3010 90507670
Hallucination, auditory 772.34 16.96 389 117378 15586 90495094
Disturbance in social behaviour 770.40 16.96 265 117502 3923 90506757
Schizophrenia 761.86 16.96 377 117390 14537 90496143
Pain 760.90 16.96 182 117585 996159 89514521
Neutrophil count normal 734.20 16.96 130 117637 0 90510680
Sexual dysfunction 727.34 16.96 263 117504 4541 90506139
Electrocardiogram QT prolonged 726.61 16.96 663 117104 71793 90438887
Platelet count increased 717.90 16.96 405 117362 20454 90490226
Arthralgia 697.90 16.96 94 117673 778428 89732252
Leukocytosis 696.53 16.96 458 117309 30532 90480148
Rash 690.68 16.96 106 117661 795994 89714686
Suicide attempt 683.03 16.96 652 117115 74747 90435933
Metabolic disorder 674.73 16.96 281 117486 7189 90503491
Mental disorder 659.96 16.96 450 117317 31868 90478812
Haemoglobin decreased 623.22 16.96 902 116865 161054 90349626
Headache 599.33 16.96 189 117578 862557 89648123
Personality change 580.23 16.96 251 117516 7070 90503610
Drug interaction 577.12 16.96 1173 116594 275280 90235400
Pruritus 568.58 16.96 34 117733 541491 89969189
Delusion 568.25 16.96 302 117465 13538 90497142
Alopecia 548.70 16.96 22 117745 495049 90015631
Fatigue 546.22 16.96 423 117344 1153600 89357080
Living in residential institution 540.24 16.96 134 117633 544 90510136
Neuroleptic malignant syndrome 535.45 16.96 299 117468 14797 90495883
Infusion related reaction 524.23 16.96 3 117764 416777 90093903
Joint swelling 524.10 16.96 33 117734 503267 90007413
Catatonia 510.82 16.96 217 117550 5839 90504841
Antipsychotic drug level above therapeutic 506.61 16.96 148 117619 1236 90509444
Nausea 478.63 16.96 445 117322 1109871 89400809
Psychiatric decompensation 473.47 16.96 152 117615 1791 90508889
Tachycardia 470.37 16.96 781 116986 156892 90353788
Troponin increased 462.73 16.96 260 117507 13021 90497659
Swelling 449.92 16.96 23 117744 419035 90091645
Rheumatoid arthritis 439.94 16.96 6 117761 362608 90148072
Drug hypersensitivity 436.86 16.96 47 117720 463562 90047118
Abdominal discomfort 430.95 16.96 56 117711 477272 90033408
Mean cell haemoglobin concentration decreased 411.47 16.96 170 117597 4258 90506422
Diarrhoea 409.55 16.96 372 117395 938818 89571862
Antipsychotic drug level decreased 407.69 16.96 97 117670 316 90510364
Pemphigus 407.64 16.96 3 117764 326861 90183819
Systemic lupus erythematosus 404.47 16.96 15 117752 361881 90148799
Arthropathy 399.86 16.96 18 117749 366224 90144456
Hypersensitivity 385.76 16.96 64 117703 454613 90056067
Sinusitis 377.37 16.96 16 117751 343072 90167608
Somnolence 369.93 16.96 830 116937 208254 90302426
Peripheral swelling 357.49 16.96 55 117712 413051 90097629
Monocyte count increased 355.18 16.96 192 117575 8905 90501775
Mean cell haemoglobin decreased 342.36 16.96 161 117606 5534 90505146
Sinus tachycardia 337.86 16.96 287 117480 28226 90482454
Pain in extremity 337.48 16.96 85 117682 450444 90060236
Overdose 334.30 16.96 674 117093 157035 90353645
Stomatitis 331.14 16.96 5 117762 274693 90235987
Drug intolerance 320.99 16.96 92 117675 447499 90063181
Wound 320.77 16.96 18 117749 302962 90207718
Eosinophilia 315.36 16.96 276 117491 28257 90482423
Haematocrit decreased 312.64 16.96 326 117441 41506 90469174
Parkinsonism 311.41 16.96 206 117561 13859 90496821
Urticaria 309.52 16.96 26 117741 312708 90197972
Blister 305.84 16.96 5 117762 254993 90255687
Nasopharyngitis 304.49 16.96 77 117690 407027 90103653
Paranoia 297.83 16.96 194 117573 12714 90497966
Extrapyramidal disorder 297.64 16.96 212 117555 16091 90494589
Red cell distribution width increased 292.82 16.96 188 117579 12019 90498661
Psychotic symptom 288.10 16.96 109 117658 2147 90508533
Hypoaesthesia 285.46 16.96 36 117731 314174 90196506
Impaired healing 283.39 16.96 4 117763 234195 90276485
Psoriatic arthropathy 280.29 16.96 3 117764 228332 90282348
Tardive dyskinesia 276.29 16.96 174 117593 10756 90499924
Therapeutic product effect decreased 274.87 16.96 23 117744 277548 90233132
Discomfort 273.69 16.96 22 117745 274313 90236367
Blood glucose increased 265.52 16.96 458 117309 94788 90415892
Red blood cell count decreased 264.98 16.96 314 117453 46037 90464643
Aggression 257.35 16.96 239 117528 26429 90484251
Agitation 252.33 16.96 370 117397 66728 90443952
Hepatic enzyme increased 247.96 16.96 80 117687 360656 90150024
Eosinophil count increased 247.82 16.96 174 117593 12907 90497773
Fibromyalgia 247.51 16.96 4 117763 206265 90304415
Abdominal pain upper 244.71 16.96 65 117702 332609 90178071
Hyperprolactinaemia 241.35 16.96 125 117642 5308 90505372
Myoclonus 239.58 16.96 199 117568 18969 90491711
Irritable bowel syndrome 230.26 16.96 9 117758 207439 90303241
Lymphocyte count increased 229.46 16.96 110 117657 3949 90506731
Lymphocyte count decreased 224.83 16.96 252 117515 34798 90475882
Suicidal ideation 218.87 16.96 365 117402 73490 90437190
Antipsychotic drug level below therapeutic 212.42 16.96 55 117712 275 90510405
Chronic obstructive pulmonary disease 210.98 16.96 359 117408 73470 90437210
Akathisia 210.38 16.96 148 117619 11011 90499669
Neoplasm malignant 207.81 16.96 238 117529 33642 90477038
Treatment failure 207.77 16.96 68 117699 303860 90206820
Pre-existing disease 207.51 16.96 49 117718 153 90510527
Dyspnoea 206.69 16.96 532 117235 880423 89630257
Abnormal behaviour 205.33 16.96 196 117571 22432 90488248
Mean cell volume decreased 203.99 16.96 105 117662 4401 90506279
Terminal state 195.48 16.96 88 117679 2730 90507950
Faecaloma 193.54 16.96 137 117630 10294 90500386
Paraesthesia 191.61 16.96 45 117722 250281 90260399
Injection site pain 187.91 16.96 9 117758 173690 90336990
C-reactive protein increased 187.59 16.96 590 117177 180799 90329881
Osteoarthritis 186.29 16.96 19 117748 195711 90314969
Wheezing 185.82 16.96 41 117726 238039 90272641
Musculoskeletal pain 184.86 16.96 9 117758 171242 90339438
Contusion 184.85 16.96 49 117718 251167 90259513
Lung neoplasm malignant 184.64 16.96 191 117576 24082 90486598
Muscle injury 182.34 16.96 12 117755 176642 90334038
Refusal of examination 182.14 16.96 45 117722 179 90510501
Dementia 181.94 16.96 188 117579 23673 90487007
Back pain 181.13 16.96 93 117674 317082 90193598
Drooling 180.40 16.96 97 117670 4449 90506231
Toxicity to various agents 179.21 16.96 795 116972 287051 90223629
Therapy cessation 176.67 16.96 227 117540 36134 90474546
Pleurothotonus 175.91 16.96 66 117701 1269 90509411
Erythema 175.86 16.96 41 117726 229205 90281475
Hallucination 174.46 16.96 310 117457 65649 90445031
Migraine 172.38 16.96 22 117745 190370 90320310
Liver injury 171.96 16.96 13 117754 170554 90340126
Gastrointestinal disorder 170.94 16.96 60 117707 256627 90254053
Pneumonia aspiration 170.42 16.96 237 117530 40703 90469977
Orthostatic hypotension 167.97 16.96 238 117529 41589 90469091
Intentional product use issue 167.95 16.96 38 117729 216854 90293826
COVID-19 165.29 16.96 539 117228 168304 90342376
Intestinal obstruction 165.21 16.96 222 117545 36909 90473771
On and off phenomenon 162.49 16.96 75 117692 2468 90508212
Joint range of motion decreased 161.17 16.96 3 117764 135640 90375040
Mean cell volume increased 160.66 16.96 93 117674 4928 90505752
General physical condition abnormal 159.13 16.96 93 117674 5018 90505662
Benign ethnic neutropenia 158.12 16.96 28 117739 0 90510680
Blood prolactin increased 153.90 16.96 81 117686 3556 90507124
Maternal exposure during pregnancy 153.46 16.96 145 117622 359918 90150762
Dyspepsia 148.92 16.96 37 117730 198123 90312557
Wrong patient received product 148.73 16.96 78 117689 3399 90507281
Muscle spasms 146.56 16.96 72 117695 251811 90258869
Breast cancer 146.47 16.96 256 117511 53505 90457175
Oculogyric crisis 145.68 16.96 69 117698 2410 90508270
Muscle rigidity 145.37 16.96 132 117635 14177 90496503
Urinary incontinence 145.33 16.96 210 117557 37356 90473324
Arthritis 145.18 16.96 22 117745 167293 90343387
Night sweats 144.88 16.96 5 117762 128761 90381919
Mania 144.87 16.96 131 117636 13993 90496687
Electroencephalogram abnormal 144.87 16.96 81 117686 4015 90506665
Choking 142.27 16.96 121 117646 11912 90498768
Generalised tonic-clonic seizure 140.74 16.96 199 117568 34704 90475976
Contraindicated product administered 139.87 16.96 126 117641 320013 90190667
Musculoskeletal stiffness 137.75 16.96 110 117657 296422 90214258
Constipation 135.30 16.96 720 117047 279675 90231005
Blood creatine phosphokinase increased 134.26 16.96 192 117575 33831 90476849
Ill-defined disorder 134.21 16.96 37 117730 184854 90325826
Neuropathy peripheral 133.74 16.96 12 117755 136958 90373722
Injury 131.59 16.96 46 117721 197303 90313377
Neutrophil count abnormal 130.86 16.96 76 117691 4052 90506628
Obsessive-compulsive disorder 129.88 16.96 78 117689 4426 90506254
Oedema 129.64 16.96 49 117718 200246 90310434
Psoriasis 129.18 16.96 19 117748 147735 90362945
Intentional self-injury 128.39 16.96 174 117593 29160 90481520
Disease progression 128.35 16.96 24 117743 156591 90354089
Hypertension 127.60 16.96 251 117516 457281 90053399
Asthenia 126.64 16.96 320 117447 533431 89977249
Seizure 124.77 16.96 459 117308 152170 90358510
Sinus rhythm 124.68 16.96 52 117715 1334 90509346
Decreased appetite 122.82 16.96 187 117580 376353 90134327
Cough 120.57 16.96 183 117584 368779 90141901
Troponin T increased 120.00 16.96 53 117714 1570 90509110
Ileus 118.34 16.96 126 117641 16420 90494260
Aspiration 116.68 16.96 122 117645 15571 90495109
Withdrawal catatonia 114.09 16.96 30 117737 161 90510519
Psychiatric symptom 110.60 16.96 84 117683 7034 90503646
Sciatica 110.45 16.96 5 117762 101377 90409303
Acute psychosis 109.22 16.96 61 117706 3017 90507663
Febrile neutropenia 108.89 16.96 35 117732 158314 90352366
Malignant neoplasm progression 108.11 16.96 8 117759 106862 90403818
Pericarditis 106.83 16.96 116 117651 270035 90240645
Mutism 106.29 16.96 50 117717 1719 90508961
Diabetes mellitus 106.18 16.96 250 117517 64625 90446055
C-reactive protein abnormal 105.54 16.96 19 117748 127410 90383270
Gastrointestinal hypomotility 104.24 16.96 45 117722 1260 90509420
Intentional overdose 104.16 16.96 313 117454 93521 90417159
Pericardial effusion 103.73 16.96 178 117589 36655 90474025
Metabolic syndrome 103.34 16.96 50 117717 1832 90508848
Drug ineffective 103.06 16.96 1229 116538 1383069 89127611
Platelet count decreased 102.10 16.96 400 117367 136569 90374111
Oedema peripheral 100.60 16.96 112 117655 257803 90252877
Electrocardiogram T wave abnormal 100.12 16.96 55 117712 2633 90508047
Schizoaffective disorder bipolar type 99.04 16.96 27 117740 170 90510510
Sleep disorder 98.98 16.96 68 117699 197962 90312718
Injection site reaction 98.83 16.96 5 117762 92075 90418605
Sopor 98.60 16.96 140 117627 24504 90486176
Blood cholesterol increased 96.77 16.96 77 117690 207935 90302745
Coronavirus infection 96.72 16.96 70 117697 5445 90505235
Grip strength decreased 96.36 16.96 6 117761 92570 90418110
Malaise 96.02 16.96 1173 116594 584813 89925867
Breast cancer stage III 95.99 16.96 3 117764 84444 90426236
Intestinal pseudo-obstruction 95.84 16.96 41 117726 1122 90509558
Peripheral venous disease 95.32 16.96 3 117764 83918 90426762
Haemoglobin increased 94.17 16.96 78 117689 7403 90503277
Dry mouth 93.61 16.96 62 117705 183997 90326683
Urinary tract infection 93.14 16.96 698 117069 304934 90205746
Gait inability 92.82 16.96 37 117730 146419 90364261
Imprisonment 92.62 16.96 29 117738 313 90510367
Wound infection 92.27 16.96 14 117753 106388 90404292
Coma 91.95 16.96 254 117513 72378 90438302
Blood alkaline phosphatase increased 91.79 16.96 197 117570 47882 90462798
Ileus paralytic 87.94 16.96 64 117703 5021 90505659
Knee arthroplasty 87.77 16.96 5 117762 83177 90427503
Muscular weakness 87.07 16.96 84 117683 206582 90304098
Visual impairment 86.27 16.96 32 117735 132333 90378347
Neck pain 86.14 16.96 21 117746 113942 90396738
Circulatory collapse 85.97 16.96 132 117635 24772 90485908
Enuresis 85.40 16.96 54 117713 3360 90507320
Refusal of treatment by patient 85.39 16.96 66 117701 5672 90505008
No adverse event 84.34 16.96 236 117531 67746 90442934
Polydipsia 84.16 16.96 58 117709 4173 90506507
Persecutory delusion 83.41 16.96 52 117715 3156 90507524
Flushing 83.11 16.96 9 117758 88482 90422198
Dry skin 82.61 16.96 9 117758 88064 90422616
Wrong product administered 82.38 16.96 73 117694 7592 90503088
Nasal congestion 82.26 16.96 7 117760 83407 90427273
Rash pruritic 80.80 16.96 7 117760 82207 90428473
Weight decreased 80.13 16.96 241 117526 379669 90131011
Myalgia 78.75 16.96 67 117700 175058 90335622
Mean platelet volume increased 78.50 16.96 33 117734 864 90509816
Hypothermia 78.43 16.96 99 117668 15476 90495204
Inappropriate schedule of product administration 78.29 16.96 49 117718 149884 90360796
Apraxia 78.01 16.96 44 117723 2218 90508462
Stoma site discharge 77.69 16.96 42 117725 1947 90508733
Investigation noncompliance 77.67 16.96 15 117752 9 90510671
Anaphylactic reaction 77.08 16.96 11 117756 87513 90423167
Live birth 77.03 16.96 7 117760 79100 90431580
Gastrooesophageal reflux disease 76.82 16.96 62 117705 166275 90344405
Head titubation 76.68 16.96 36 117731 1232 90509448
Electrocardiogram abnormal 76.45 16.96 80 117687 10218 90500462
Vomiting 75.69 16.96 658 117109 787635 89723045
Delirium 75.52 16.96 302 117465 104057 90406623
Cardiomyopathy 75.31 16.96 111 117656 20095 90490585
Lung cancer metastatic 75.22 16.96 47 117720 2864 90507816
Monocyte count decreased 75.05 16.96 45 117722 2546 90508134
Product dispensing error 74.88 16.96 86 117681 12187 90498493
Electrocardiogram T wave inversion 74.47 16.96 51 117716 3632 90507048
Bipolar disorder 74.34 16.96 74 117693 8911 90501769
Lung disorder 74.18 16.96 52 117715 149831 90360849
Mean cell haemoglobin increased 74.09 16.96 52 117715 3853 90506827
Thrombocytosis 73.90 16.96 66 117701 6935 90503745
Posture abnormal 73.16 16.96 45 117722 2666 90508014
Mobility decreased 72.91 16.96 134 117633 250600 90260080
Freezing phenomenon 72.84 16.96 39 117728 1773 90508907
Inflammation 72.46 16.96 75 117692 178517 90332163
Immature granulocyte count increased 72.26 16.96 27 117740 513 90510167
Prescribed underdose 72.08 16.96 7 117760 75012 90435668
Epistaxis 72.00 16.96 12 117755 85113 90425567
Prescribed overdose 71.83 16.96 19 117748 97606 90413074
Myocardial fibrosis 70.51 16.96 31 117736 908 90509772
Haematocrit increased 70.36 16.96 46 117721 3032 90507648
Polyserositis 69.93 16.96 28 117739 645 90510035
Mental status changes 68.61 16.96 168 117599 44511 90466169
Liver disorder 68.49 16.96 36 117731 121233 90389447
Personality change due to a general medical condition 67.85 16.96 22 117745 268 90510412
Insomnia 67.85 16.96 215 117552 333259 90177421
Product quality issue 67.50 16.96 11 117756 79314 90431366
Depressed level of consciousness 67.27 16.96 228 117539 72556 90438124
Chest discomfort 65.88 16.96 50 117717 138315 90372365
Impaired self-care 65.48 16.96 36 117731 1726 90508954
Pneumonia 65.36 16.96 1178 116589 636881 89873799
Apathy 65.07 16.96 76 117691 10964 90499716
Rebound psychosis 64.98 16.96 20 117747 203 90510477
Herpes zoster 64.91 16.96 21 117746 94623 90416057
Haematochezia 64.63 16.96 8 117759 70905 90439775
Basophil count increased 64.47 16.96 31 117736 1120 90509560
Joint stiffness 63.83 16.96 12 117755 78030 90432650
Osteoporosis 63.47 16.96 23 117744 96508 90414172
Bronchitis 63.43 16.96 63 117704 152864 90357816
Stoma site erythema 62.40 16.96 33 117734 1463 90509217
Cardiac arrest 62.30 16.96 286 117481 104649 90406031
Gastrointestinal carcinoma 62.28 16.96 38 117729 2219 90508461
Hallucination, visual 61.64 16.96 109 117658 22983 90487697
Hot flush 61.48 16.96 4 117763 59484 90451196
Loss of consciousness 61.44 16.96 351 117416 139887 90370793
Fluid retention 61.39 16.96 19 117748 88072 90422608
Blood urea decreased 61.16 16.96 40 117727 2638 90508042
Red blood cell count increased 61.08 16.96 45 117722 3598 90507082
Bradykinesia 60.07 16.96 58 117709 6730 90503950
Hyperkinesia 59.95 16.96 35 117732 1884 90508796
Asthma 59.81 16.96 142 117625 242018 90268662
Sudden death 59.20 16.96 72 117695 10837 90499843
Mucosal inflammation 59.18 16.96 4 117763 57621 90453059
Abdominal pain 58.91 16.96 289 117478 395432 90115248
Therapeutic product effect incomplete 58.73 16.96 101 117666 193795 90316885
Taste disorder 58.46 16.96 6 117761 61540 90449140
Liver function test increased 57.89 16.96 19 117748 84836 90425844
Hip arthroplasty 57.67 16.96 14 117753 76194 90434486
Eosinopenia 56.97 16.96 15 117752 81 90510599
Bundle branch block right 56.75 16.96 51 117716 5402 90505278
Gamma-glutamyltransferase increased 56.47 16.96 141 117626 37811 90472869
Foreign body ingestion 56.47 16.96 10 117757 0 90510680
Psychotic behaviour 56.27 16.96 24 117743 652 90510028
Stoma site irritation 55.91 16.96 20 117747 334 90510346
Behaviour disorder 55.60 16.96 47 117720 4588 90506092
Volvulus 55.49 16.96 35 117732 2168 90508512
Loss of personal independence in daily activities 55.38 16.96 57 117710 136048 90374632
Megacolon 55.33 16.96 35 117732 2179 90508501
Road traffic accident 55.05 16.96 36 117731 107590 90403090
Condition aggravated 54.92 16.96 502 117265 595043 89915637
Social avoidant behaviour 54.63 16.96 41 117726 3372 90507308
Colitis ulcerative 54.43 16.96 7 117760 60259 90450421
Type 2 diabetes mellitus 54.42 16.96 114 117653 203130 90307550
Movement disorder 54.35 16.96 118 117649 28901 90481779
High density lipoprotein decreased 54.29 16.96 37 117730 2614 90508066
Ataxia 53.19 16.96 89 117678 17953 90492727
Psychiatric evaluation 53.11 16.96 11 117756 14 90510666
Palliative care 53.05 16.96 25 117742 863 90509817
Frequent bowel movements 52.93 16.96 6 117761 56929 90453751
Thrombocytopenia 52.80 16.96 457 117310 208268 90302412
Drug monitoring procedure incorrectly performed 52.75 16.96 19 117748 324 90510356
Skin exfoliation 52.33 16.96 12 117755 67901 90442779
Borderline personality disorder 51.86 16.96 26 117741 1030 90509650
Dizziness 51.23 16.96 504 117263 588780 89921900
Rash erythematous 51.18 16.96 11 117756 65093 90445587
Throat irritation 51.15 16.96 3 117764 48692 90461988
Myocardial infarction 50.93 16.96 272 117495 105700 90404980
Blood pressure increased 50.83 16.96 113 117654 197104 90313576
Negativism 50.68 16.96 20 117747 443 90510237
Dysarthria 50.64 16.96 171 117596 54311 90456369
Lethargy 49.98 16.96 188 117579 62951 90447729
Multiple sclerosis relapse 49.94 16.96 5 117762 52300 90458380
Suicidal behaviour 49.65 16.96 36 117731 2808 90507872
Blepharospasm 48.75 16.96 7 117760 55438 90455242
Rhinorrhoea 48.73 16.96 27 117740 88289 90422391
Dyspnoea exertional 47.90 16.96 17 117750 72271 90438409
Upper respiratory tract infection 47.54 16.96 58 117709 128260 90382420
Monocytosis 47.43 16.96 24 117743 970 90509710
Pancreatic fibrosis 47.26 16.96 13 117754 85 90510595
Dry eye 47.18 16.96 9 117758 57922 90452758
Exposure during pregnancy 46.87 16.96 156 117611 238254 90272426
Myelosuppression 46.57 16.96 7 117760 53584 90457096
Product use issue 46.21 16.96 246 117521 329673 90181007
Foreign body in gastrointestinal tract 45.86 16.96 12 117755 63 90510617
Lupus-like syndrome 45.78 16.96 5 117762 48841 90461839
Psychomotor hyperactivity 45.76 16.96 69 117698 12744 90497936
Back injury 45.73 16.96 4 117763 46618 90464062
Cardiac disorder 45.56 16.96 170 117597 56702 90453978
Asterixis 45.55 16.96 28 117739 1657 90509023
Chills 45.46 16.96 63 117704 131918 90378762
Insurance issue 44.94 16.96 63 117704 10895 90499785
Rectal haemorrhage 44.64 16.96 26 117741 82718 90427962
Autoimmune disorder 44.50 16.96 22 117745 76722 90433958
X-ray abnormal 44.27 16.96 4 117763 45420 90465260
Metastatic neoplasm 44.23 16.96 42 117725 4773 90505907
Anaemia 44.01 16.96 673 117094 352129 90158551
Vascular encephalopathy 43.93 16.96 21 117746 749 90509931
Follicular lymphoma stage IV 43.70 16.96 10 117757 26 90510654
Hypercholesterolaemia 43.66 16.96 40 117727 100852 90409828
Galactorrhoea 43.39 16.96 41 117726 4631 90506049
Fall 42.91 16.96 871 116896 480939 90029741
Ear pain 42.89 16.96 11 117756 57691 90452989
Dysphemia 42.85 16.96 34 117733 3036 90507644
Eye pain 42.75 16.96 4 117763 44164 90466516
Parkinson's disease 42.53 16.96 23 117744 1067 90509613
Drug-induced liver injury 42.52 16.96 33 117734 90285 90420395
Akinesia 42.28 16.96 27 117740 1709 90508971
Unresponsive to stimuli 42.13 16.96 127 117640 37994 90472686
Burning sensation 41.91 16.96 15 117752 63437 90447243
Blood albumin decreased 41.89 16.96 77 117690 16726 90493954
Subileus 41.77 16.96 36 117731 3608 90507072
Intellectual disability 41.62 16.96 24 117743 1262 90509418
Device expulsion 41.52 16.96 3 117764 40883 90469797
Cataract 41.30 16.96 21 117746 72071 90438609
Dysgeusia 41.07 16.96 9 117758 52551 90458129
Cervix neoplasm 41.02 16.96 14 117753 202 90510478
Blood triglycerides increased 40.72 16.96 68 117699 13693 90496987
Ankle fracture 40.65 16.96 85 117682 20285 90490395
Ovarian cancer 40.58 16.96 47 117720 6720 90503960
Swelling face 40.54 16.96 28 117739 81324 90429356
Tremor 40.11 16.96 338 117429 152835 90357845
Interstitial lung disease 39.83 16.96 25 117742 76380 90434300
Thrombosis 39.54 16.96 23 117744 73228 90437452
Sepsis 39.53 16.96 382 117385 179432 90331248
Body temperature increased 39.51 16.96 138 117629 44572 90466108
Self-injurious ideation 39.49 16.96 33 117734 3170 90507510
Self-destructive behaviour 39.44 16.96 17 117750 474 90510206
Blood bilirubin decreased 39.44 16.96 21 117746 944 90509736
Tobacco interaction 39.35 16.96 11 117756 77 90510603
Acute kidney injury 38.94 16.96 250 117517 320137 90190543
Hepatitis C 38.54 16.96 42 117725 5618 90505062
Electroconvulsive therapy 38.46 16.96 10 117757 51 90510629
Angiodermatitis 38.45 16.96 13 117754 182 90510498
Coeliac disease 38.37 16.96 6 117761 44604 90466076
Small intestinal obstruction 38.24 16.96 85 117682 21149 90489531
Hypokalaemia 38.15 16.96 70 117697 131046 90379634
Swollen tongue 37.72 16.96 7 117760 45949 90464731
Microcytosis 37.68 16.96 13 117754 194 90510486
Impulsive behaviour 37.47 16.96 25 117742 1705 90508975
Pulmonary embolism 37.12 16.96 294 117473 130526 90380154
Fibroma 36.43 16.96 20 117747 956 90509724
Hypophagia 36.27 16.96 116 117651 35821 90474859
Malignant catatonia 36.02 16.96 13 117754 223 90510457
Troponin abnormal 35.89 16.96 10 117757 69 90510611
Cardiac steatosis 35.81 16.96 9 117758 39 90510641
Victim of chemical submission 35.72 16.96 18 117749 721 90509959
Eye movement disorder 35.42 16.96 42 117725 6156 90504524
Affective disorder 35.28 16.96 47 117720 7746 90502934
Overweight 35.22 16.96 41 117726 5893 90504787
Amnesia 35.20 16.96 54 117713 108451 90402229
Tonic clonic movements 35.18 16.96 24 117743 1698 90508982
Central obesity 34.80 16.96 22 117745 1368 90509312
Disorientation 34.62 16.96 131 117636 43983 90466697
Echocardiogram abnormal 34.38 16.96 23 117744 1576 90509104
Pregnancy 34.18 16.96 19 117748 62028 90448652
Respiratory failure 34.07 16.96 267 117500 118151 90392529
Incoherent 34.01 16.96 37 117730 4940 90505740
Productive cough 34.00 16.96 30 117737 77033 90433647
Speech disorder 33.83 16.96 133 117634 45452 90465228
Dysphonia 33.78 16.96 20 117747 63064 90447616
Feeling hot 33.66 16.96 31 117736 77977 90432703
Hepatotoxicity 33.57 16.96 9 117758 45833 90464847
Liver function test abnormal 33.51 16.96 143 117624 50702 90459978
Glomerular filtration rate decreased 33.03 16.96 70 117697 16862 90493818
Grandiosity 32.61 16.96 13 117754 296 90510384
Poor personal hygiene 32.60 16.96 14 117753 387 90510293
Basal cell carcinoma 32.38 16.96 3 117764 33386 90477294
Procedural pain 32.34 16.96 3 117764 33357 90477323
Pain in jaw 32.28 16.96 11 117756 47974 90462706
Gestational diabetes 32.27 16.96 53 117714 10529 90500151
Intestinal strangulation 32.19 16.96 10 117757 105 90510575
Altered state of consciousness 32.02 16.96 102 117665 31430 90479250
Stoma site pain 31.96 16.96 21 117746 1396 90509284
Abnormal clotting factor 31.93 16.96 10 117757 108 90510572
Depression 31.89 16.96 244 117523 300357 90210323
Hypotension 31.89 16.96 597 117170 324800 90185880
Finger deformity 31.79 16.96 3 117764 32894 90477786
Hypocalcaemia 31.63 16.96 8 117759 42360 90468320
Dementia with Lewy bodies 31.62 16.96 14 117753 417 90510263
Oral pain 31.53 16.96 3 117764 32680 90478000
Angioedema 31.44 16.96 23 117744 64853 90445827
Congenital eye disorder 31.41 16.96 8 117759 37 90510643
Left ventricular dysfunction 31.38 16.96 63 117704 14606 90496074
Endocarditis enterococcal 31.22 16.96 12 117755 247 90510433
Pulmonary valve incompetence 31 16.96 22 117745 1659 90509021
Body mass index increased 30.91 16.96 21 117746 1476 90509204
Serositis 30.88 16.96 20 117747 1297 90509383
Left ventricular hypertrophy 30.85 16.96 39 117728 6105 90504575
Cystitis 30.62 16.96 25 117742 66693 90443987
Feeling abnormal 30.46 16.96 113 117654 167122 90343558
Congenital nystagmus 30.41 16.96 8 117759 43 90510637
Waxy flexibility 30.18 16.96 10 117757 131 90510549
Toxicologic test abnormal 30.11 16.96 16 117751 716 90509964
Physical assault 29.92 16.96 17 117750 869 90509811
Influenza B virus test positive 29.83 16.96 12 117755 280 90510400
Medication error 29.60 16.96 200 117567 84452 90426228
Memory impairment 29.34 16.96 144 117623 197100 90313580
Diverticulitis 29.30 16.96 11 117756 45176 90465504
Product administration error 29.17 16.96 88 117679 26335 90484345
Hepatic cirrhosis 28.66 16.96 24 117743 63229 90447451
Ear infection 28.63 16.96 29 117738 69746 90440934
Stoma site reaction 28.59 16.96 12 117755 313 90510367
Parkinsonism hyperpyrexia syndrome 28.42 16.96 11 117756 231 90510449
Disturbance in attention 28.39 16.96 129 117638 46980 90463700
Pseudophaeochromocytoma 28.35 16.96 9 117758 102 90510578
Parotitis 28.34 16.96 22 117745 1903 90508777
Miosis 28.24 16.96 47 117720 9437 90501243
Sneezing 28.14 16.96 3 117764 29866 90480814
Cognitive disorder 27.98 16.96 170 117597 69237 90441443
Eczema 27.97 16.96 17 117750 52853 90457827
Hyperthermia 27.86 16.96 49 117718 10286 90500394
Hyperkalaemia 27.81 16.96 26 117741 64938 90445742
Arteriosclerosis coronary artery 27.81 16.96 47 117720 9556 90501124
Breast cancer stage II 27.71 16.96 6 117761 35328 90475352
Underdose 27.71 16.96 18 117749 53999 90456681
Postmortem blood drug level increased 27.65 16.96 15 117752 700 90509980
Neuralgia 27.64 16.96 4 117763 31496 90479184
Eye swelling 27.56 16.96 3 117764 29383 90481297
Monocyte percentage increased 27.48 16.96 18 117749 1190 90509490
Neutrophil percentage increased 27.21 16.96 26 117741 2977 90507703
Neglect of personal appearance 27.02 16.96 9 117758 120 90510560
Neoplasm progression 26.95 16.96 12 117755 44474 90466206
Blood bicarbonate increased 26.85 16.96 16 117751 895 90509785
Troponin I increased 26.80 16.96 24 117743 2531 90508149
Visceral congestion 26.48 16.96 12 117755 378 90510302
Metamyelocyte count increased 26.47 16.96 10 117757 196 90510484
Gastrointestinal sounds abnormal 26.32 16.96 31 117736 4512 90506168
Disability 26.29 16.96 10 117757 40735 90469945
Mitral valve replacement 26.24 16.96 13 117754 502 90510178
Suspiciousness 26.16 16.96 12 117755 389 90510291
Drug tolerance decreased 26.15 16.96 5 117762 32125 90478555
Ventricular extrasystoles 26.10 16.96 55 117712 13195 90497485
Anisocytosis 26.06 16.96 15 117752 786 90509894
Oropharyngeal spasm 26.06 16.96 11 117756 291 90510389
Eating disorder 25.98 16.96 88 117679 27985 90482695
Globulin abnormal 25.89 16.96 5 117762 3 90510677
Immunodeficiency 25.67 16.96 12 117755 43222 90467458
Restlessness 25.53 16.96 103 117664 35617 90475063
International normalised ratio increased 25.33 16.96 15 117752 47301 90463379
Skin discolouration 25.25 16.96 13 117754 44302 90466378
Stevens-Johnson syndrome 25.15 16.96 4 117763 29372 90481308
Left atrial enlargement 25.13 16.96 14 117753 689 90509991
Fungal infection 25.08 16.96 12 117755 42649 90468031
Chemotherapy 25.00 16.96 20 117747 1807 90508873
Red blood cell nucleated morphology present 24.89 16.96 6 117761 21 90510659
Abdominal tenderness 24.87 16.96 44 117723 9280 90501400
Gynaecomastia 24.71 16.96 10 117757 237 90510443
Thinking abnormal 24.64 16.96 50 117717 11682 90498998
Atrial fibrillation 24.52 16.96 90 117677 133521 90377159
Haematoma 24.51 16.96 10 117757 39038 90471642
Breast cancer metastatic 24.41 16.96 58 117709 15074 90495606
Hypochromasia 24.38 16.96 11 117756 343 90510337
Product dispensing issue 24.35 16.96 12 117755 458 90510222
Nodule 24.34 16.96 3 117764 26683 90483997
Mean cell haemoglobin concentration increased 24.06 16.96 13 117754 602 90510078
Lip swelling 24.05 16.96 10 117757 38600 90472080
Tinnitus 24.03 16.96 13 117754 43089 90467591
Lymphoma 24.02 16.96 54 117713 13537 90497143
Flat affect 23.99 16.96 19 117748 1692 90508988
Vision blurred 23.91 16.96 69 117698 110224 90400456
Drug dose titration not performed 23.91 16.96 14 117753 758 90509922
Palpitations 23.86 16.96 94 117673 136634 90374046
Delusion of grandeur 23.85 16.96 10 117757 260 90510420
Parotid gland enlargement 23.80 16.96 15 117752 928 90509752
Postictal psychosis 23.79 16.96 8 117759 110 90510570
Abdominal compartment syndrome 23.72 16.96 14 117753 769 90509911
Drug-disease interaction 23.70 16.96 15 117752 935 90509745
Rehabilitation therapy 23.64 16.96 20 117747 1954 90508726
Blunted affect 23.60 16.96 10 117757 267 90510413
Haemoptysis 23.55 16.96 7 117760 33313 90477367
Electrocardiogram change 23.54 16.96 14 117753 780 90509900
Incontinence 23.32 16.96 53 117714 13382 90497298
Hypersensitivity myocarditis 23.30 16.96 10 117757 276 90510404
B-cell lymphoma 23.01 16.96 26 117741 3620 90507060
Body mass index decreased 22.98 16.96 12 117755 518 90510162
Wrong drug 22.90 16.96 10 117757 288 90510392
Colitis ischaemic 22.89 16.96 50 117717 12296 90498384
Delusion of reference 22.79 16.96 8 117759 126 90510554
Electrocardiogram PR shortened 22.75 16.96 12 117755 529 90510151
Non-high-density lipoprotein cholesterol increased 22.70 16.96 9 117758 202 90510478
Blood phosphorus increased 22.62 16.96 28 117739 4290 90506390
Mean cell haemoglobin concentration 22.59 16.96 4 117763 0 90510680
Myelocyte present 22.59 16.96 4 117763 0 90510680
Cogwheel rigidity 22.55 16.96 20 117747 2082 90508598
Muscle spasticity 22.24 16.96 9 117758 35313 90475367
Asphyxia 22.23 16.96 36 117731 7067 90503613
Heart rate decreased 22.22 16.96 22 117745 53483 90457197
Brain hypoxia 22.18 16.96 12 117755 557 90510123
Depressed mood 22.17 16.96 126 117641 50096 90460584
Judgement impaired 22.14 16.96 14 117753 871 90509809
Alcohol poisoning 22.14 16.96 19 117748 1893 90508787
Mean platelet volume decreased 22.05 16.96 23 117744 2927 90507753
Acne 22.03 16.96 5 117762 28502 90482178
Poverty of speech 21.98 16.96 10 117757 318 90510362
Therapy non-responder 21.98 16.96 97 117670 136607 90374073
Activated partial thromboplastin time abnormal 21.91 16.96 8 117759 142 90510538
Laryngeal cancer stage III 21.85 16.96 5 117762 13 90510667
Plasma cell myeloma 21.78 16.96 13 117754 40815 90469865
Transferrin saturation decreased 21.77 16.96 14 117753 897 90509783
Granulocytosis 21.56 16.96 8 117759 149 90510531
Osteonecrosis 21.53 16.96 4 117763 26237 90484443
Brain neoplasm 21.50 16.96 29 117738 4835 90505845
Hallucinations, mixed 21.44 16.96 32 117735 5857 90504823
Pressure of speech 21.34 16.96 13 117754 757 90509923
Congestive cardiomyopathy 21.31 16.96 36 117731 7318 90503362
Consciousness fluctuating 21.29 16.96 14 117753 932 90509748
Intestinal ischaemia 21.26 16.96 40 117727 8843 90501837
Anxiety disorder 21.24 16.96 29 117738 4893 90505787
Hypervolaemia 21.20 16.96 8 117759 32749 90477931
Sedation complication 21.18 16.96 59 117708 16885 90493795
Drug monitoring procedure not performed 21.08 16.96 13 117754 774 90509906
Torticollis 21.04 16.96 21 117746 2537 90508143
Hypomagnesaemia 20.94 16.96 10 117757 35578 90475102
Urosepsis 20.94 16.96 68 117699 21164 90489516
Intestinal dilatation 20.93 16.96 20 117747 2290 90508390
Nervousness 20.93 16.96 9 117758 34047 90476633
Oral candidiasis 20.80 16.96 10 117757 35445 90475235
Drug eruption 20.75 16.96 10 117757 35397 90475283
Hepatic steatosis 20.67 16.96 99 117668 36846 90473834
Aspartate aminotransferase decreased 20.67 16.96 14 117753 979 90509701
Autoimmune myocarditis 20.62 16.96 9 117758 259 90510421
Nephrolithiasis 20.60 16.96 20 117747 49065 90461615
Vertigo 20.55 16.96 37 117730 69774 90440906
Neutrophil toxic granulation present 20.54 16.96 8 117759 171 90510509
Rash maculo-papular 20.51 16.96 14 117753 40919 90469761
Staring 20.17 16.96 17 117750 1653 90509027
Bladder trabeculation 20.14 16.96 6 117761 54 90510626
QRS axis abnormal 20.10 16.96 15 117752 1223 90509457
Wrong patient 20.06 16.96 13 117754 844 90509836
Self-induced vomiting 20.04 16.96 6 117761 55 90510625
Osteopenia 20.00 16.96 3 117764 22999 90487681
Electrocardiogram T wave amplitude decreased 19.90 16.96 10 117757 398 90510282
Respiratory syncytial virus test positive 19.87 16.96 14 117753 1044 90509636
Neutrophil percentage decreased 19.73 16.96 11 117756 542 90510138
Abulia 19.72 16.96 12 117755 697 90509983
Myelocyte count increased 19.72 16.96 10 117757 406 90510274
Resting tremor 19.71 16.96 13 117754 870 90509810
Protein total decreased 19.61 16.96 34 117733 7055 90503625
Product dose omission issue 19.58 16.96 507 117260 291180 90219500
Polydipsia psychogenic 19.45 16.96 7 117760 119 90510561
Sexually inappropriate behaviour 19.45 16.96 7 117760 119 90510561
Basophil count decreased 19.42 16.96 9 117758 299 90510381
Blood bicarbonate decreased 19.27 16.96 22 117745 3097 90507583
Gastrointestinal haemorrhage 19.17 16.96 57 117710 90191 90420489
Limb discomfort 19.09 16.96 13 117754 38047 90472633
Rhabdomyolysis 19.07 16.96 123 117644 51133 90459547
Major depression 19.01 16.96 41 117726 9994 90500686
Blood pressure systolic increased 18.96 16.96 29 117738 58316 90452364
Drug level above therapeutic 18.95 16.96 30 117737 5779 90504901
Injection site mass 18.93 16.96 3 117764 22087 90488593
Gastrointestinal obstruction 18.93 16.96 15 117752 1337 90509343
Joint dislocation 18.90 16.96 18 117749 44564 90466116
Small cell lung cancer 18.87 16.96 17 117750 1807 90508873
Aortic valve replacement 18.85 16.96 13 117754 936 90509744
Nuchal rigidity 18.76 16.96 12 117755 762 90509918
Blood chloride increased 18.76 16.96 22 117745 3188 90507492
Echolalia 18.75 16.96 9 117758 324 90510356
Drug level decreased 18.72 16.96 40 117727 9690 90500990
Gallbladder cholesterolosis 18.56 16.96 12 117755 776 90509904
Circulating anticoagulant positive 18.55 16.96 5 117762 30 90510650
Appendicitis 18.47 16.96 41 117726 10190 90500490
Hypersexuality 18.46 16.96 11 117756 615 90510065
Electrocardiogram ST-T change 18.42 16.96 13 117754 972 90509708
Flatulence 18.37 16.96 16 117751 41351 90469329
Coma scale abnormal 18.27 16.96 29 117738 5597 90505083
Conjunctivitis 18.18 16.96 6 117761 26700 90483980
Illness anxiety disorder 18.17 16.96 7 117760 145 90510535
Myocardial ischaemia 18.16 16.96 49 117718 13765 90496915
Skin ulcer 18.16 16.96 23 117744 50052 90460628
Petit mal epilepsy 18.13 16.96 27 117740 4931 90505749
Soliloquy 18.10 16.96 9 117758 350 90510330
Leukaemia 17.99 16.96 27 117740 4965 90505715
Photophobia 17.98 16.96 3 117764 21266 90489414
Cervix cancer metastatic 17.94 16.96 6 117761 81 90510599
Postmortem blood drug level abnormal 17.89 16.96 8 117759 244 90510436
Blood osmolarity increased 17.85 16.96 9 117758 361 90510319
Lower limb fracture 17.83 16.96 54 117713 84959 90425721
Withdrawal syndrome 17.76 16.96 67 117700 22457 90488223
Quarantine 17.76 16.96 5 117762 36 90510644
Thyroxine free decreased 17.76 16.96 12 117755 836 90509844
Persistent depressive disorder 17.71 16.96 14 117753 1243 90509437
Eosinophilic myocarditis 17.55 16.96 11 117756 674 90510006
Urinary retention 17.53 16.96 96 117671 37648 90473032
Anion gap increased 17.51 16.96 18 117749 2252 90508428
Lactic acidosis 17.46 16.96 24 117743 50439 90460241
Stupor 17.45 16.96 28 117739 5454 90505226
Melaena 17.30 16.96 12 117755 34785 90475895
Respiratory tract congestion 17.23 16.96 7 117760 27403 90483277
Eye disorder 17.21 16.96 7 117760 27383 90483297
Device related infection 17.19 16.96 6 117761 25780 90484900
Patient elopement 17.18 16.96 7 117760 169 90510511
Chest pain 17.16 16.96 302 117465 319343 90191337
Skin lesion 17.15 16.96 14 117753 37351 90473329
Heart rate increased 17.11 16.96 223 117544 112679 90398001
Sputum discoloured 16.96 16.96 3 117764 20388 90490292

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 10698.87 16.32 5589 181170 68741 42365835
Neutropenia 9638.21 16.32 7510 179249 191921 42242655
Neutrophilia 5369.70 16.32 1653 185106 3839 42430737
Neutrophil count increased 5321.34 16.32 2295 184464 17509 42417067
White blood cell count increased 4277.62 16.32 2586 184173 42501 42392075
Differential white blood cell count abnormal 3444.66 16.32 909 185850 835 42433741
Granulocytopenia 3314.53 16.32 1227 185532 5887 42428689
Death 2894.36 16.32 6346 180413 464839 41969737
Mental impairment 2576.35 16.32 1199 185560 11118 42423458
Myocarditis 2474.82 16.32 1340 185419 17598 42416978
Antipsychotic drug level increased 2400.50 16.32 866 185893 3800 42430776
Psychotic disorder 2364.60 16.32 1516 185243 27692 42406884
Treatment noncompliance 2271.17 16.32 1629 185130 36043 42398533
Salivary hypersecretion 2015.24 16.32 976 185783 9967 42424609
White blood cell count decreased 1813.23 16.32 2322 184437 108074 42326502
Neutrophil count decreased 1798.58 16.32 1774 184985 61641 42372935
Agranulocytosis 1531.61 16.32 1184 185575 29428 42405148
Sedation 1288.44 16.32 1068 185691 29407 42405169
Therapy interrupted 1262.34 16.32 928 185831 21322 42413254
Neuroleptic malignant syndrome 1165.28 16.32 872 185887 20600 42413976
Eosinophil count decreased 1124.32 16.32 464 186295 3112 42431464
Schizophrenia 1075.88 16.32 635 186124 9915 42424661
Tachycardia 1066.20 16.32 1724 185035 99363 42335213
Hallucination, auditory 918.33 16.32 653 186106 14211 42420365
Leukopenia 857.03 16.32 1325 185434 73421 42361155
Neutrophil count normal 842.68 16.32 190 186569 0 42434576
Leukocytosis 833.54 16.32 827 185932 28881 42405695
Mental disorder 818.82 16.32 659 186100 17370 42417206
Antipsychotic drug level decreased 800.43 16.32 270 186489 923 42433653
Platelet count increased 702.48 16.32 488 186271 10215 42424361
Rash 696.77 16.32 178 186581 276776 42157800
Troponin increased 669.28 16.32 601 186158 18461 42416115
Arthralgia 660.18 16.32 67 186692 205171 42229405
C-reactive protein increased 654.43 16.32 1073 185686 62487 42372089
Pruritus 652.79 16.32 45 186714 188726 42245850
Antipsychotic drug level below therapeutic 648.19 16.32 305 186454 2899 42431677
Delusion 634.13 16.32 522 186237 14212 42420364
Diarrhoea 633.05 16.32 654 186105 460195 41974381
Eosinophil count increased 617.17 16.32 452 186307 10311 42424265
Acute kidney injury 614.45 16.32 431 186328 366906 42067670
Haemoglobin decreased 573.25 16.32 1568 185191 130903 42303673
Nausea 567.62 16.32 543 186216 396256 42038320
Catatonia 567.44 16.32 349 186410 5890 42428686
Fatigue 554.30 16.32 658 186101 434983 41999593
Febrile neutropenia 554.27 16.32 78 186681 185625 42248951
Monocyte count increased 549.92 16.32 331 186428 5363 42429213
Lower respiratory tract infection 508.03 16.32 756 186003 40450 42394126
Imprisonment 497.02 16.32 162 186597 482 42434094
Pain 490.59 16.32 230 186529 244618 42189958
Antipsychotic drug level above therapeutic 473.90 16.32 187 186572 1097 42433479
Headache 453.72 16.32 242 186517 239127 42195449
Dyspnoea 445.33 16.32 788 185971 441833 41992743
Red blood cell count decreased 431.90 16.32 620 186139 32095 42402481
Living in residential institution 426.62 16.32 147 186612 545 42434031
Malaise 424.76 16.32 1947 184812 210209 42224367
Sinus tachycardia 416.79 16.32 483 186276 20170 42414406
Faecaloma 416.38 16.32 288 186471 5982 42428594
Malignant neoplasm progression 415.78 16.32 13 186746 108387 42326189
Obsessive-compulsive disorder 413.53 16.32 295 186464 6448 42428128
Haematocrit decreased 411.11 16.32 627 186132 34281 42400295
Blood creatine phosphokinase increased 400.78 16.32 742 186017 47596 42386980
Aggression 386.51 16.32 694 186065 43469 42391107
Pain in extremity 385.55 16.32 93 186666 150511 42284065
Psychiatric decompensation 365.77 16.32 229 186530 3993 42430583
Mean cell haemoglobin decreased 361.01 16.32 178 186581 1892 42432684
Paranoia 359.51 16.32 372 186387 13654 42420922
Akathisia 355.93 16.32 324 186435 10127 42424449
Eosinophilia 345.92 16.32 561 186198 32338 42402238
Psychotic symptom 345.35 16.32 181 186578 2209 42432367
Therapy cessation 343.77 16.32 436 186323 20014 42414562
Asthenia 341.68 16.32 438 186321 280355 42154221
Benign ethnic neutropenia 338.31 16.32 81 186678 24 42434552
Erythema 338.10 16.32 40 186719 108753 42325823
Disease progression 335.38 16.32 106 186653 143550 42291026
Extrapyramidal disorder 328.09 16.32 382 186377 16030 42418546
Back pain 324.99 16.32 108 186651 141668 42292908
Lymphocyte count increased 311.35 16.32 204 186555 3860 42430716
Gastrointestinal hypomotility 305.13 16.32 137 186622 1156 42433420
Decreased appetite 302.31 16.32 242 186517 192895 42241681
Drooling 296.16 16.32 202 186557 4097 42430479
Schizoaffective disorder 289.82 16.32 151 186608 1819 42432757
Oedema peripheral 286.10 16.32 119 186640 135957 42298619
Lymphocyte count decreased 285.29 16.32 469 186290 27340 42407236
Urticaria 279.88 16.32 10 186749 74026 42360550
Pneumonia aspiration 276.87 16.32 651 186108 49427 42385149
Abnormal behaviour 276.62 16.32 450 186309 26001 42408575
Cardiomyopathy 272.66 16.32 377 186382 18833 42415743
Peripheral swelling 271.23 16.32 37 186722 90233 42344343
Lung neoplasm malignant 269.12 16.32 374 186385 18773 42415803
Mean cell haemoglobin concentration decreased 266.49 16.32 132 186627 1418 42433158
Atrial fibrillation 264.36 16.32 141 186618 139452 42295124
Hyperkalaemia 264.35 16.32 24 186735 80434 42354142
Drug hypersensitivity 258.95 16.32 59 186700 99330 42335246
Neuropathy peripheral 258.40 16.32 64 186695 101789 42332787
Mean cell volume decreased 255.40 16.32 131 186628 1524 42433052
Agitation 244.31 16.32 727 186032 63587 42370989
Electrocardiogram QT prolonged 241.19 16.32 601 186158 47344 42387232
Joint swelling 238.44 16.32 15 186744 68007 42366569
Suicide attempt 236.26 16.32 582 186177 45518 42389058
Drug level increased 235.92 16.32 417 186342 25783 42408793
Neoplasm malignant 235.21 16.32 385 186374 22358 42412218
Interstitial lung disease 233.73 16.32 33 186726 78429 42356147
Dyskinesia 232.37 16.32 407 186352 24983 42409593
Off label use 226.53 16.32 1756 185003 636579 41797997
Inappropriate schedule of product administration 225.09 16.32 70 186689 95832 42338744
Orthostatic hypotension 223.48 16.32 445 186314 30125 42404451
Delirium 209.33 16.32 604 186155 51915 42382661
Muscle rigidity 208.84 16.32 261 186498 11798 42422778
Red cell distribution width increased 206.61 16.32 200 186559 6764 42427812
Intestinal obstruction 205.36 16.32 401 186358 26757 42407819
Epistaxis 204.05 16.32 26 186733 66800 42367776
Stomatitis 200.62 16.32 4 186755 50325 42384251
Paraesthesia 198.69 16.32 40 186719 73419 42361157
Overdose 195.40 16.32 946 185813 104318 42330258
Anosognosia 194.74 16.32 94 186665 950 42433626
Pre-existing disease 194.11 16.32 51 186708 45 42434531
Injection site pain 193.22 16.32 16 186743 57782 42376794
Muscle spasms 187.74 16.32 71 186688 85973 42348603
Thrombosis 185.93 16.32 37 186722 68474 42366102
Cough 185.73 16.32 309 186450 177794 42256782
Haematochezia 185.21 16.32 20 186739 58416 42376160
Disinhibition 180.21 16.32 144 186615 3751 42430825
Cytokine release syndrome 179.68 16.32 3 186756 44524 42390052
Tardive dyskinesia 178.06 16.32 184 186575 6740 42427836
Intentional product use issue 176.68 16.32 48 186711 71785 42362791
Drug ineffective 174.67 16.32 1845 184914 628352 41806224
Neutrophil count abnormal 173.98 16.32 123 186636 2648 42431928
Pericarditis 173.27 16.32 252 186507 13192 42421384
Therapeutic product effect variable 172.41 16.32 128 186631 2981 42431595
Anaphylactic reaction 171.98 16.32 3 186756 42740 42391836
Persecutory delusion 169.69 16.32 134 186625 3430 42431146
Ileus paralytic 168.21 16.32 187 186572 7454 42427122
Obesity 166.64 16.32 276 186483 16183 42418393
Mean cell volume increased 164.59 16.32 137 186622 3786 42430790
Troponin T increased 164.44 16.32 119 186640 2661 42431915
Chills 163.85 16.32 105 186654 93961 42340615
Enuresis 161.11 16.32 117 186642 2631 42431945
Thinking abnormal 160.65 16.32 177 186582 6984 42427592
Dry skin 159.88 16.32 14 186745 48324 42386252
Renal failure 158.65 16.32 240 186519 143486 42291090
Left ventricular dysfunction 157.65 16.32 222 186537 11279 42423297
Platelet count decreased 155.53 16.32 1090 185669 137491 42297085
Hypoaesthesia 154.17 16.32 60 186699 71403 42363173
Ascites 152.97 16.32 31 186728 56647 42377929
Pancytopenia 152.03 16.32 175 186584 117568 42317008
Hypersensitivity 150.86 16.32 64 186695 72306 42362270
Sinusitis 150.34 16.32 16 186743 47276 42387300
Swelling 150.27 16.32 29 186730 54856 42379720
General physical condition abnormal 150.02 16.32 135 186624 4154 42430422
Hypokalaemia 148.59 16.32 64 186695 71657 42362919
Myalgia 148.13 16.32 122 186637 95958 42338618
International normalised ratio increased 146.42 16.32 19 186740 48149 42386427
Dystonia 145.26 16.32 226 186533 12564 42422012
Wheezing 143.67 16.32 32 186727 54749 42379827
Choking 143.59 16.32 157 186602 6141 42428435
Withdrawal catatonia 143.13 16.32 50 186709 195 42434381
Intestinal pseudo-obstruction 141.36 16.32 100 186659 2155 42432421
Rheumatoid arthritis 138.46 16.32 13 186746 42427 42392149
Anaemia 137.63 16.32 696 186063 279582 42154994
Blood prolactin abnormal 135.84 16.32 74 186685 981 42433595
Seizure 135.08 16.32 948 185811 119613 42314963
On and off phenomenon 133.00 16.32 115 186644 3352 42431224
Lactic acidosis 132.53 16.32 20 186739 45241 42389335
Dizziness 132.23 16.32 602 186157 248652 42185924
Hepatitis C 132.13 16.32 191 186568 9942 42424634
Left ventricular hypertrophy 130.88 16.32 182 186577 9137 42425439
Renal impairment 130.59 16.32 175 186584 110053 42324523
Product use in unapproved indication 129.47 16.32 397 186362 184059 42250517
Weight decreased 128.58 16.32 473 186286 207475 42227101
Electrocardiogram abnormal 127.60 16.32 188 186571 9957 42424619
Arthritis 126.88 16.32 17 186742 42048 42392528
Investigation noncompliance 125.21 16.32 30 186729 9 42434567
Bradycardia 125.14 16.32 114 186645 85370 42349206
Dysgeusia 124.56 16.32 6 186753 34183 42400393
Myelosuppression 122.88 16.32 16 186743 40445 42394131
Sedation complication 122.59 16.32 102 186657 2817 42431759
Skin exfoliation 122.50 16.32 18 186741 41535 42393041
Gastrointestinal haemorrhage 122.13 16.32 149 186610 97577 42336999
Dyspnoea exertional 120.53 16.32 35 186724 50113 42384463
Euphoric mood 120.35 16.32 145 186614 6308 42428268
Hallucination 120.00 16.32 535 186224 56972 42377604
Megacolon 119.87 16.32 91 186668 2194 42432382
Muscular weakness 119.11 16.32 114 186645 83384 42351192
Freezing phenomenon 118.95 16.32 84 186675 1805 42432771
Cardiac failure congestive 118.51 16.32 120 186639 85482 42349094
Circulatory collapse 118.51 16.32 296 186463 23340 42411236
Terminal state 118.19 16.32 120 186639 4303 42430273
Cholinergic rebound syndrome 114.08 16.32 29 186730 19 42434557
Haematuria 112.86 16.32 56 186703 57743 42376833
Hypoglycaemia 112.41 16.32 61 186698 59793 42374783
Psoriasis 111.30 16.32 37 186722 48567 42386009
COVID-19 110.73 16.32 878 185881 115070 42319506
Refusal of examination 109.93 16.32 26 186733 6 42434570
Blood prolactin increased 108.54 16.32 86 186673 2212 42432364
Body temperature increased 108.49 16.32 261 186498 20097 42414479
Multiple organ dysfunction syndrome 108.03 16.32 161 186598 96874 42337702
Plasma cell myeloma 107.59 16.32 37 186722 47541 42387035
Psychiatric symptom 105.99 16.32 111 186648 4130 42430446
Drug reaction with eosinophilia and systemic symptoms 105.56 16.32 27 186732 42048 42392528
Intentional self-injury 104.77 16.32 216 186543 14986 42419590
Rectal haemorrhage 104.77 16.32 43 186716 49563 42385013
Condition aggravated 104.62 16.32 691 186068 260063 42174513
Wrong patient received product 104.59 16.32 102 186657 3481 42431095
Abdominal pain upper 104.22 16.32 125 186634 82484 42352092
Musculoskeletal pain 104.15 16.32 12 186747 33328 42401248
Haemorrhage 103.53 16.32 69 186690 60494 42374082
Vision blurred 103.39 16.32 53 186706 53646 42380930
Somnolence 103.37 16.32 1008 185751 140097 42294479
Rash pruritic 102.74 16.32 13 186746 33590 42400986
Eczema 102.27 16.32 14 186745 34072 42400504
Oedema 102.11 16.32 50 186709 51951 42382625
Rebound psychosis 101.83 16.32 37 186722 166 42434410
Constipation 101.69 16.32 1123 185636 161168 42273408
Immature granulocyte count increased 101.59 16.32 40 186719 233 42434343
Delusion of grandeur 101.43 16.32 78 186681 1918 42432658
Delusional disorder, persecutory type 101.29 16.32 43 186716 312 42434264
Suicidal ideation 101.18 16.32 449 186310 47712 42386864
Hypomagnesaemia 100.66 16.32 6 186753 28482 42406094
Apathy 100.33 16.32 152 186607 8254 42426322
Rash maculo-papular 100.18 16.32 21 186738 37482 42397094
Pneumonitis 98.65 16.32 30 186729 41688 42392888
Abdominal pain 97.99 16.32 465 186294 190006 42244570
Angioedema 97.85 16.32 32 186727 42445 42392131
Increased appetite 97.84 16.32 155 186604 8751 42425825
Haemoptysis 97.53 16.32 40 186719 46127 42388449
Disturbance in social behaviour 97.23 16.32 73 186686 1730 42432846
Mean cell haemoglobin concentration increased 97.19 16.32 48 186711 512 42434064
Haemoglobin increased 97.12 16.32 117 186642 5089 42429487
Pneumocystis jirovecii pneumonia 96.56 16.32 3 186756 25178 42409398
Myoclonus 95.50 16.32 223 186536 16842 42417734
Abdominal discomfort 93.74 16.32 115 186644 75140 42359436
Psychiatric evaluation 93.13 16.32 21 186738 0 42434576
Hepatitis C virus test positive 92.10 16.32 39 186720 281 42434295
Tinnitus 91.44 16.32 10 186749 28928 42405648
Heart rate increased 91.19 16.32 468 186291 52787 42381789
Basophil count increased 91.13 16.32 51 186708 715 42433861
Herpes zoster 90.06 16.32 29 186730 38848 42395728
Oculogyric crisis 89.75 16.32 69 186690 1696 42432880
Prostate cancer 89.06 16.32 42 186717 44601 42389975
Troponin I increased 88.93 16.32 88 186671 3058 42431518
Neuralgia 88.83 16.32 6 186753 25641 42408935
Aspiration 88.62 16.32 223 186536 17663 42416913
Red blood cell count increased 88.30 16.32 70 186689 1802 42432774
Nephrolithiasis 87.96 16.32 26 186733 36804 42397772
Gout 87.88 16.32 10 186749 28045 42406531
Electrocardiogram T wave abnormal 86.25 16.32 68 186691 1736 42432840
Fluid retention 85.92 16.32 17 186742 31602 42402974
Dysphemia 85.19 16.32 69 186690 1833 42432743
Tobacco interaction 83.66 16.32 27 186732 77 42434499
Rash erythematous 83.63 16.32 19 186740 32072 42402504
Body mass index increased 83.22 16.32 57 186702 1164 42433412
Cardiac disorder 83.07 16.32 429 186330 48503 42386073
Sexual dysfunction 82.98 16.32 124 186635 6651 42427925
Social avoidant behaviour 82.21 16.32 87 186672 3277 42431299
Skin lesion 81.90 16.32 11 186748 27163 42407413
Leukaemia 81.46 16.32 113 186646 5659 42428917
Haematoma 80.63 16.32 13 186746 28010 42406566
Parkinsonism 80.46 16.32 157 186602 10466 42424110
Acute psychosis 79.85 16.32 70 186689 2079 42432497
Mean platelet volume increased 79.69 16.32 44 186715 600 42433976
Nasopharyngitis 79.13 16.32 155 186604 83841 42350735
Echocardiogram abnormal 78.87 16.32 56 186703 1214 42433362
Blood triglycerides increased 78.56 16.32 198 186561 15698 42418878
Blood urea decreased 78.22 16.32 58 186701 1348 42433228
Ventricular fibrillation 78.17 16.32 18 186741 30105 42404471
Drug intolerance 77.87 16.32 146 186613 80278 42354298
Drug monitoring procedure incorrectly performed 77.80 16.32 36 186723 328 42434248
Cerebral haemorrhage 77.21 16.32 37 186722 38929 42395647
Coronavirus infection 76.49 16.32 104 186655 5110 42429466
Generalised tonic-clonic seizure 76.42 16.32 272 186487 26107 42408469
Gastrointestinal carcinoma 75.56 16.32 65 186694 1881 42432695
Intestinal dilatation 74.98 16.32 59 186700 1502 42433074
Melaena 74.94 16.32 38 186721 38708 42395868
Lung cancer metastatic 74.35 16.32 78 186681 2908 42431668
Cataract 74.20 16.32 21 186738 30583 42403993
Septic shock 74.16 16.32 184 186575 91488 42343088
Hepatic function abnormal 73.99 16.32 70 186689 51497 42383079
Psychotic behaviour 73.35 16.32 48 186711 906 42433670
Drug dose titration not performed 73.30 16.32 36 186723 379 42434197
QRS axis abnormal 72.94 16.32 57 186702 1436 42433140
Neutrophil count 72.94 16.32 22 186737 46 42434530
Dry mouth 72.91 16.32 42 186717 39837 42394739
Cerebral infarction 72.64 16.32 23 186736 31146 42403430
Hypocalcaemia 72.61 16.32 21 186738 30152 42404424
Ventricular tachycardia 72.56 16.32 21 186738 30139 42404437
Dehydration 72.33 16.32 347 186412 141420 42293156
Neck pain 72.02 16.32 21 186738 29993 42404583
Congestive cardiomyopathy 71.89 16.32 134 186625 8630 42425946
Wrong patient 71.85 16.32 41 186718 598 42433978
Productive cough 71.68 16.32 72 186687 51495 42383081
Basal cell carcinoma 71.46 16.32 8 186751 22725 42411851
Deep vein thrombosis 70.78 16.32 144 186615 76813 42357763
Weight increased 70.24 16.32 753 186006 107230 42327346
Obstructive airways disorder 70.09 16.32 12 186747 24747 42409829
Coma scale abnormal 69.93 16.32 93 186666 4472 42430104
Mucosal inflammation 69.71 16.32 68 186691 49306 42385270
Bronchopulmonary aspergillosis 68.92 16.32 4 186755 19425 42415151
Frequent bowel movements 68.66 16.32 7 186752 21400 42413176
Visual impairment 68.60 16.32 53 186706 43060 42391516
Insomnia 68.47 16.32 276 186483 117977 42316599
Bronchitis 67.81 16.32 64 186695 47137 42387439
Colitis ischaemic 67.60 16.32 117 186642 7109 42427467
Toxic epidermal necrolysis 67.42 16.32 17 186742 26733 42407843
Stoma site discharge 67.07 16.32 54 186705 1422 42433154
Diplopia 66.86 16.32 6 186753 20310 42414266
Migraine 66.31 16.32 15 186744 25399 42409177
Blood creatinine increased 66.08 16.32 253 186506 109750 42324826
Hyponatraemia 65.80 16.32 226 186533 101236 42333340
Parkinson's disease 65.73 16.32 51 186708 1271 42433305
Hyperbilirubinaemia 65.53 16.32 7 186752 20628 42413948
Ejection fraction decreased 65.06 16.32 229 186530 21858 42412718
Pulmonary valve incompetence 64.75 16.32 48 186711 1115 42433461
Candida infection 64.53 16.32 9 186750 21601 42412975
Lip swelling 64.43 16.32 5 186754 19048 42415528
Dementia 64.13 16.32 188 186571 16292 42418284
Sudden death 64.04 16.32 189 186570 16440 42418136
Therapeutic product effect decreased 63.74 16.32 47 186712 39103 42395473
Refusal of treatment by patient 63.60 16.32 96 186663 5195 42429381
Foetal exposure during pregnancy 63.56 16.32 68 186691 47243 42387333
Drug eruption 63.56 16.32 12 186747 23063 42411513
Metabolic disorder 63.52 16.32 91 186668 4697 42429879
Suspiciousness 63.44 16.32 33 186726 396 42434180
Blister 62.80 16.32 21 186738 27469 42407107
Upper gastrointestinal haemorrhage 62.79 16.32 27 186732 30272 42404304
Mania 62.52 16.32 141 186618 10406 42424170
Osteoarthritis 62.50 16.32 15 186744 24390 42410186
Acute myocardial infarction 62.32 16.32 99 186660 58066 42376510
Monocyte count decreased 62.10 16.32 52 186707 1449 42433127
Impaired healing 62.09 16.32 3 186756 17050 42417526
Eosinopenia 62.05 16.32 16 186743 12 42434564
Pleural effusion 61.95 16.32 218 186541 96948 42337628
Heart rate decreased 61.92 16.32 42 186717 36490 42398086
Rhinorrhoea 61.76 16.32 31 186728 31763 42402813
Bundle branch block right 61.63 16.32 120 186639 7986 42426590
Asthma 61.31 16.32 112 186647 62202 42372374
Swelling face 61.31 16.32 22 186737 27532 42407044
Coronary artery disease 60.87 16.32 88 186671 53632 42380944
Polydipsia psychogenic 60.36 16.32 24 186735 144 42434432
Diverticulitis 60.31 16.32 13 186746 22760 42411816
Myelodysplastic syndrome 60.21 16.32 13 186746 22732 42411844
Bone pain 60.19 16.32 15 186744 23777 42410799
Colitis ulcerative 59.79 16.32 20 186739 26155 42408421
Cholestasis 59.58 16.32 35 186724 32844 42401732
Metabolic syndrome 58.91 16.32 57 186702 1926 42432650
Shock haemorrhagic 58.68 16.32 3 186756 16239 42418337
Clostridium difficile colitis 58.64 16.32 11 186748 21241 42413335
Nasal congestion 58.46 16.32 28 186731 29473 42405103
Disseminated intravascular coagulation 58.31 16.32 18 186741 24776 42409800
Lymphoma 58.27 16.32 166 186593 14155 42420421
Myasthenia gravis 58.24 16.32 3 186756 16134 42418442
Influenza like illness 58.15 16.32 285 186474 31555 42403021
Full blood count decreased 58.13 16.32 10 186749 20550 42414026
Contraindicated product administered 57.97 16.32 242 186517 25030 42409546
Lymphocyte count abnormal 57.83 16.32 59 186700 2128 42432448
Staphylococcal infection 57.73 16.32 48 186711 37595 42396981
Device related infection 57.03 16.32 10 186749 20269 42414307
Stoma site erythema 56.94 16.32 42 186717 968 42433608
Dysuria 56.49 16.32 33 186726 31063 42403513
Affective disorder 56.41 16.32 97 186662 5863 42428713
Hepatotoxicity 56.15 16.32 20 186739 25147 42409429
Flushing 55.82 16.32 48 186711 36980 42397596
Hypervolaemia 55.82 16.32 16 186743 23109 42411467
Bacteraemia 55.70 16.32 20 186739 25020 42409556
Prostatic specific antigen increased 55.69 16.32 5 186754 16920 42417656
Burning sensation 55.64 16.32 12 186747 21001 42413575
Hyperprolactinaemia 55.64 16.32 57 186702 2066 42432510
Visual acuity reduced 55.61 16.32 6 186753 17544 42417032
Bronchiectasis 55.01 16.32 7 186752 18012 42416564
Ocular hyperaemia 54.51 16.32 4 186755 15959 42418617
Swollen tongue 54.46 16.32 13 186746 21218 42413358
End stage renal disease 54.19 16.32 5 186754 16553 42418023
Pericardial effusion 54.15 16.32 263 186496 29012 42405564
Premature baby 54.10 16.32 17 186742 23136 42411440
Mouth ulceration 53.32 16.32 3 186756 14960 42419616
Overweight 53.03 16.32 59 186700 2353 42432223
SARS-CoV-2 test positive 53.00 16.32 114 186645 8146 42426430
Intellectual disability 52.80 16.32 53 186706 1874 42432702
Fungal infection 52.76 16.32 11 186748 19711 42414865
Pleurothotonus 52.28 16.32 43 186716 1168 42433408
Chest discomfort 51.98 16.32 127 186632 63489 42371087
Dysphonia 51.95 16.32 30 186729 28420 42406156
Feeling hot 51.82 16.32 19 186740 23463 42411113
Schizoaffective disorder bipolar type 51.74 16.32 21 186738 134 42434442
Haemorrhage intracranial 51.71 16.32 7 186752 17185 42417391
Impaired self-care 51.48 16.32 43 186716 1194 42433382
Wrong technique in product usage process 51.15 16.32 67 186692 42568 42392008
Globulins decreased 51.12 16.32 27 186732 335 42434241
Hepatic cytolysis 50.91 16.32 27 186732 26817 42407759
Alcohol abuse 50.87 16.32 75 186684 3974 42430602
Volvulus 50.87 16.32 53 186706 1960 42432616
Mean cell haemoglobin increased 50.78 16.32 55 186704 2128 42432448
Multiple sclerosis relapse 50.40 16.32 3 186756 14261 42420315
Malignant catatonia 50.40 16.32 29 186730 430 42434146
Loss of personal independence in daily activities 50.39 16.32 88 186671 49728 42384848
Pulmonary fibrosis 50.36 16.32 27 186732 26654 42407922
Contusion 50.35 16.32 66 186693 41919 42392657
Hypotension 50.28 16.32 810 185949 256821 42177755
Hypertension 50.27 16.32 479 186280 166725 42267851
Arthropathy 50.20 16.32 34 186725 29563 42405013
Hepatic failure 49.81 16.32 56 186703 38044 42396532
Type 2 diabetes mellitus 49.73 16.32 186 186573 18285 42416291
Hot flush 49.46 16.32 18 186741 22333 42412243
Ischaemic stroke 49.04 16.32 18 186741 22215 42412361
Blood pressure systolic increased 48.96 16.32 31 186728 27937 42406639
Hypoacusis 48.87 16.32 11 186748 18691 42415885
Osteonecrosis 48.83 16.32 6 186753 15859 42418717
Respiratory failure 48.57 16.32 345 186414 127787 42306789
Toxic skin eruption 48.18 16.32 3 186756 13727 42420849
Angina pectoris 47.96 16.32 44 186715 32852 42401724
Transaminases increased 47.93 16.32 44 186715 32841 42401735
Vertigo 47.68 16.32 48 186711 34299 42400277
Neurotoxicity 47.56 16.32 22 186737 23629 42410947
Palliative care 47.19 16.32 40 186719 1134 42433442
Tension 46.98 16.32 56 186703 2408 42432168
Gastrointestinal necrosis 46.95 16.32 73 186686 4055 42430521
Withdrawal syndrome 46.84 16.32 157 186602 14618 42419958
Proteinuria 46.80 16.32 21 186738 22962 42411614
Eye pain 46.60 16.32 9 186750 17021 42417555
Bone marrow failure 46.22 16.32 46 186713 33047 42401529
Jaundice 46.14 16.32 50 186709 34539 42400037
Blood bilirubin increased 46.13 16.32 71 186688 42181 42392395
Dysarthria 45.67 16.32 315 186444 39492 42395084
Coagulopathy 45.52 16.32 20 186739 22142 42412434
Discomfort 45.48 16.32 27 186732 25192 42409384
Hypoalbuminaemia 45.45 16.32 7 186752 15603 42418973
Cardiac failure 45.39 16.32 278 186481 106578 42327998
Fibroma 44.98 16.32 26 186733 389 42434187
Obsessive thoughts 44.63 16.32 34 186725 824 42433752
Pseudomonas infection 44.46 16.32 8 186751 15915 42418661
Blindness 44.21 16.32 12 186747 17966 42416610
Lymphocyte percentage increased 44.04 16.32 21 186738 206 42434370
Stoma site inflammation 43.84 16.32 28 186731 506 42434070
Appendicitis perforated 43.72 16.32 50 186709 2056 42432520
Obsessive-compulsive symptom 43.61 16.32 21 186738 211 42434365
Reduced facial expression 43.55 16.32 43 186716 1490 42433086
Nightmare 43.41 16.32 28 186731 24984 42409592
Oxygen saturation decreased 43.35 16.32 142 186617 64545 42370031
Gastrooesophageal reflux disease 43.33 16.32 82 186677 44941 42389635
Total cholesterol/HDL ratio increased 43.24 16.32 20 186739 182 42434394
High density lipoprotein decreased 43.05 16.32 68 186691 3829 42430747
Monocytosis 43.03 16.32 32 186727 747 42433829
Hypoxia 42.86 16.32 159 186600 69627 42364949
Posture abnormal 42.74 16.32 54 186705 2467 42432109
Stoma site reaction 42.68 16.32 23 186736 298 42434278
Dermatitis atopic 42.67 16.32 3 186756 12401 42422175
Chromaturia 42.60 16.32 9 186750 15980 42418596
Behaviour disorder 42.59 16.32 95 186664 6959 42427617
Blood pressure increased 42.35 16.32 267 186492 101661 42332915
Dyslipidaemia 42.11 16.32 113 186646 9305 42425271
Mean platelet volume decreased 42.11 16.32 30 186729 654 42433922
Product quality issue 42.02 16.32 13 186746 17869 42416707
Bradykinesia 41.97 16.32 81 186678 5355 42429221
Acute respiratory distress syndrome 41.88 16.32 42 186717 30066 42404510
Lymphadenopathy 41.51 16.32 51 186708 33314 42401262
Hypersplenism 41.15 16.32 27 186732 512 42434064
Skin discolouration 41.13 16.32 20 186739 20870 42413706
Treatment failure 40.92 16.32 139 186620 62485 42372091
Hypercalcaemia 40.89 16.32 14 186745 18044 42416532
Confusional state 40.85 16.32 992 185767 166605 42267971
No adverse event 40.83 16.32 302 186457 38719 42395857
Hyperkinesia 40.53 16.32 48 186711 2050 42432526
Skin disorder 40.39 16.32 12 186747 16932 42417644
Rhinalgia 40.36 16.32 45 186714 1799 42432777
Drug level changed 40.34 16.32 24 186735 380 42434196
Cholinergic syndrome 40.32 16.32 29 186730 642 42433934
Feeling abnormal 40.29 16.32 163 186596 69623 42364953
Benign prostatic hyperplasia 40.18 16.32 21 186738 21031 42413545
Lacrimation increased 40.00 16.32 3 186756 11755 42422821
Throat irritation 39.95 16.32 5 186754 13031 42421545
Clostridium difficile infection 39.82 16.32 25 186734 22634 42411942
Bacterial infection 39.81 16.32 38 186721 27841 42406735
Drug interaction 39.81 16.32 1487 185272 265512 42169064
Polyneuropathy 39.68 16.32 16 186743 18645 42415931
Joint stiffness 39.59 16.32 4 186755 12318 42422258
Inappropriate affect 39.42 16.32 30 186729 726 42433850
Ankle fracture 39.41 16.32 74 186685 4792 42429784
Red cell distribution width decreased 39.38 16.32 21 186738 266 42434310
Haemorrhoids 39.16 16.32 13 186746 17084 42417492
Lung disorder 38.88 16.32 96 186663 47827 42386749
Dilatation ventricular 38.88 16.32 52 186707 2514 42432062
Disorientation 38.85 16.32 283 186476 36106 42398470
Delusional disorder, unspecified type 38.55 16.32 30 186729 751 42433825
Incorrect route of product administration 38.51 16.32 30 186729 24275 42410301
Enterococcal infection 38.44 16.32 4 186755 12035 42422541
Rehabilitation therapy 38.40 16.32 35 186724 1095 42433481
Blood sodium increased 38.13 16.32 58 186701 3160 42431416
Electrocardiogram T wave inversion 38.00 16.32 49 186710 2285 42432291
Basophil count decreased 37.70 16.32 16 186743 116 42434460
Skin ulcer 37.61 16.32 34 186725 25567 42409009
Rash papular 37.52 16.32 4 186755 11807 42422769
Ventricular hypokinesia 37.47 16.32 89 186670 6795 42427781
Flatulence 37.43 16.32 33 186726 25119 42409457
Viral infection 37.37 16.32 196 186563 22287 42412289
Chronic kidney disease 37.27 16.32 96 186663 47145 42387431
Sopor 37.27 16.32 135 186624 13067 42421509
Viral myocarditis 37.27 16.32 19 186740 218 42434358
Acute myeloid leukaemia 37.16 16.32 26 186733 22230 42412346
Hyperglycaemia 37.10 16.32 92 186667 45767 42388809
Metamyelocyte count increased 37.09 16.32 24 186735 444 42434132
Autism spectrum disorder 37.04 16.32 55 186704 2933 42431643
Renal tubular necrosis 37.02 16.32 17 186742 18337 42416239
Electrocardiogram ST segment elevation 37.00 16.32 81 186678 5858 42428718
Myelocyte count increased 36.98 16.32 23 186736 396 42434180
Haematotoxicity 36.81 16.32 3 186756 10982 42423594
Waxy flexibility 36.79 16.32 15 186744 97 42434479
Rash macular 36.71 16.32 14 186745 16877 42417699
Sepsis 36.47 16.32 634 186125 198700 42235876
COVID-19 pneumonia 36.42 16.32 25 186734 21588 42412988
Haemolytic anaemia 36.33 16.32 5 186754 12122 42422454
Pemphigoid 36.13 16.32 4 186755 11463 42423113
Suicidal behaviour 36.04 16.32 39 186720 1507 42433069
Urinary tract infection 35.86 16.32 623 186136 98661 42335915
Encephalopathy 35.77 16.32 80 186679 41253 42393323
Blood pressure decreased 35.76 16.32 133 186626 58199 42376377
Impaired quality of life 35.74 16.32 9 186750 14168 42420408
Anion gap increased 35.73 16.32 45 186714 2049 42432527
Restlessness 35.67 16.32 235 186524 29014 42405562
Nodule 35.64 16.32 6 186753 12528 42422048
Vasculitis 35.63 16.32 18 186741 18376 42416200
Drowning 35.56 16.32 24 186735 478 42434098
Epilepsy 35.47 16.32 216 186543 25955 42408621
Purpura 35.34 16.32 5 186754 11874 42422702
Musculoskeletal stiffness 35.22 16.32 132 186627 57633 42376943
Ulcer 35.12 16.32 14 186745 16427 42418149
Dementia with Lewy bodies 35.02 16.32 30 186729 863 42433713
Eosinophilic colitis 34.79 16.32 20 186739 296 42434280
Drug ineffective for unapproved indication 34.76 16.32 96 186663 46067 42388509
Stress 34.76 16.32 90 186669 44122 42390454
Bipolar disorder 34.74 16.32 62 186697 3860 42430716
Urinary incontinence 34.72 16.32 187 186572 21481 42413095
Blood osmolarity decreased 34.38 16.32 26 186733 623 42433953
Depression 34.31 16.32 317 186442 111046 42323530
Thrombocytopenia 34.18 16.32 1083 185676 189196 42245380
Photosensitivity reaction 34.15 16.32 7 186752 12695 42421881
Alcoholic seizure 34.13 16.32 10 186749 18 42434558
Drug-induced liver injury 34.01 16.32 73 186686 38200 42396376
Blood osmolarity increased 33.95 16.32 22 186737 408 42434168
Gastrointestinal disorder 33.67 16.32 99 186660 46554 42388022
Pulmonary arterial hypertension 33.54 16.32 3 186756 10184 42424392
Electrocardiogram change 33.37 16.32 26 186733 652 42433924
Aplastic anaemia 32.94 16.32 7 186752 12377 42422199
Faecal vomiting 32.90 16.32 26 186733 666 42433910
Hypothermia 32.84 16.32 125 186634 12390 42422186
Amnesia 32.78 16.32 46 186713 28391 42406185
Erythema multiforme 32.68 16.32 3 186756 9974 42424602
Blood creatinine decreased 32.63 16.32 58 186701 3600 42430976
Presyncope 32.57 16.32 30 186729 22357 42412219
Fall 32.53 16.32 1296 185463 233224 42201352
Spleen congestion 32.53 16.32 20 186739 337 42434239
Waist circumference increased 32.51 16.32 30 186729 954 42433622
Cardiogenic shock 32.49 16.32 67 186692 35573 42399003
Drug abuse 32.38 16.32 298 186461 104473 42330103
Tendonitis 32.35 16.32 3 186756 9891 42424685
Gastric ulcer 32.30 16.32 20 186739 18242 42416334
Personality change 32.28 16.32 75 186684 5644 42428932
Neutrophil percentage decreased 32.28 16.32 20 186739 342 42434234
Lymphocytosis 32.26 16.32 52 186707 2979 42431597
Nephropathy toxic 31.84 16.32 17 186742 16821 42417755
Loss of libido 31.77 16.32 52 186707 3018 42431558
Tricuspid valve incompetence 31.68 16.32 114 186645 10999 42423577
Incontinence 31.60 16.32 83 186676 6747 42427829
Therapeutic response shortened 31.58 16.32 10 186749 13544 42421032
Electrocardiogram QT interval abnormal 31.51 16.32 13 186746 87 42434489
Angina unstable 31.43 16.32 6 186753 11442 42423134
Lower limb fracture 31.24 16.32 68 186691 4899 42429677
Micturition urgency 31.09 16.32 7 186752 11891 42422685
Foreign body ingestion 31.04 16.32 7 186752 0 42434576
Tonic clonic movements 31.03 16.32 34 186725 1333 42433243
Liver disorder 30.94 16.32 81 186678 39563 42395013
Learning disability 30.86 16.32 20 186739 371 42434205
Anisocytosis 30.46 16.32 23 186736 550 42434026
Neoplasm progression 30.45 16.32 50 186709 28950 42405626
Pulmonary hypertension 30.42 16.32 35 186724 23534 42411042
Subdural haematoma 30.25 16.32 34 186725 23104 42411472
Postmortem blood drug level increased 30.13 16.32 22 186737 499 42434077
Osteoporosis 29.76 16.32 14 186745 14892 42419684
Cogwheel rigidity 29.62 16.32 38 186721 1763 42432813
Oral candidiasis 29.59 16.32 13 186746 14392 42420184
Water intoxication 29.56 16.32 20 186739 400 42434176
Rebound effect 29.50 16.32 85 186674 7294 42427282
Staphylococcal sepsis 29.25 16.32 7 186752 11407 42423169
Urticaria cholinergic 29.17 16.32 9 186750 21 42434555
Haemodialysis 28.98 16.32 5 186754 10255 42424321
Hepatic enzyme increased 28.98 16.32 103 186656 45681 42388895
Device malfunction 28.89 16.32 9 186750 12318 42422258
Drug dependence 28.87 16.32 52 186707 29042 42405534
Priapism 28.77 16.32 77 186682 6330 42428246
Febrile bone marrow aplasia 28.67 16.32 5 186754 10176 42424400
Hypothyroidism 28.67 16.32 61 186698 32023 42402553
Cardiac failure chronic 28.66 16.32 4 186755 9597 42424979
Face oedema 28.60 16.32 12 186747 13654 42420922
Immature granulocyte percentage increased 28.56 16.32 7 186752 3 42434573
Substance abuse 28.56 16.32 95 186664 8810 42425766
Thrombocytosis 28.48 16.32 64 186695 4711 42429865
Eosinophilic pleural effusion 28.39 16.32 18 186741 321 42434255
Product prescribing error 28.38 16.32 44 186715 26068 42408508
Carditis 28.36 16.32 16 186743 228 42434348
Subarachnoid haemorrhage 28.27 16.32 14 186745 14458 42420118
Blood lactate dehydrogenase decreased 28.24 16.32 16 186743 230 42434346
Blunted affect 28.17 16.32 19 186740 378 42434198
Myositis 28.12 16.32 15 186744 14851 42419725
Left atrial dilatation 28.05 16.32 43 186716 2359 42432217
Vomiting 28.04 16.32 1013 185746 288710 42145866
Colitis 28.01 16.32 107 186652 46465 42388111
Testis cancer 27.98 16.32 34 186725 1492 42433084
Intervertebral disc protrusion 27.97 16.32 7 186752 11065 42423511
Gastric haemorrhage 27.85 16.32 6 186753 10509 42424067
Cardiomegaly 27.75 16.32 146 186613 16620 42417956
Peripheral sensory neuropathy 27.75 16.32 3 186756 8759 42425817
Hepatic encephalopathy 27.73 16.32 19 186740 16423 42418153
Polydipsia 27.72 16.32 61 186698 4427 42430149
Myocardial fibrosis 27.71 16.32 31 186728 1244 42433332
Limb injury 27.70 16.32 14 186745 14291 42420285
Blood test abnormal 27.60 16.32 121 186638 12785 42421791
Skin cancer 27.53 16.32 8 186751 11454 42423122
Oliguria 27.52 16.32 4 186755 9309 42425267
Large intestinal obstruction 27.47 16.32 36 186723 1706 42432870
Electroencephalogram abnormal 27.41 16.32 48 186711 2944 42431632
Electrolyte imbalance 27.23 16.32 21 186738 17080 42417496
Urine output decreased 27.22 16.32 7 186752 10866 42423710
Small intestinal obstruction 27.17 16.32 147 186612 16914 42417662
Bladder cancer 27.06 16.32 21 186738 17026 42417550
Hypersensitivity myocarditis 26.98 16.32 10 186749 48 42434528
Granulocytosis 26.97 16.32 16 186743 252 42434324
Neglect of personal appearance 26.95 16.32 18 186741 352 42434224
Deafness 26.76 16.32 12 186747 13128 42421448
Alopecia 26.72 16.32 55 186704 29221 42405355
Cholangitis 26.68 16.32 7 186752 10720 42423856
Taste disorder 26.68 16.32 6 186753 10201 42424375
Hiccups 26.60 16.32 10 186749 12161 42422415
Liver function test increased 26.57 16.32 29 186730 19969 42414607
Delusional perception 26.56 16.32 14 186745 173 42434403
Throat tightness 26.42 16.32 5 186754 9594 42424982
Patient restraint 26.37 16.32 11 186748 76 42434500
Impaired work ability 26.31 16.32 10 186749 12081 42422495
Hallucination, visual 26.31 16.32 170 186589 20850 42413726
Anuria 26.01 16.32 9 186750 11523 42423053
Pancreatitis acute 25.87 16.32 69 186690 33495 42401081
Illusion 25.83 16.32 27 186732 1002 42433574
Aspartate aminotransferase increased 25.82 16.32 215 186544 76948 42357628
Substance use 25.79 16.32 35 186724 1716 42432860
Glaucoma 25.68 16.32 3 186756 8245 42426331
Enterocolitis 25.62 16.32 6 186753 9923 42424653
Blood folate decreased 25.56 16.32 25 186734 856 42433720
Dermatitis 25.55 16.32 10 186749 11865 42422711
Pulmonary haemorrhage 25.52 16.32 9 186750 11388 42423188
Radiation inflammation 25.42 16.32 27 186732 1021 42433555
Pneumothorax 25.28 16.32 40 186719 23503 42411073
Retrograde ejaculation 25.22 16.32 20 186739 515 42434061
Tangentiality 25.14 16.32 12 186747 118 42434458
Antisocial personality disorder 25.01 16.32 10 186749 61 42434515
Alcohol detoxification 25 16.32 8 186751 22 42434554
Incoherent 24.88 16.32 60 186699 4625 42429951
Faecalith 24.88 16.32 7 186752 10 42434566
Musculoskeletal chest pain 24.83 16.32 9 186750 11195 42423381
Breath sounds abnormal 24.70 16.32 11 186748 12082 42422494
Osteomyelitis 24.68 16.32 26 186733 18197 42416379
Cardio-respiratory arrest 24.65 16.32 153 186606 58483 42376093
Testicular germ cell cancer metastatic 24.61 16.32 10 186749 64 42434512
Staphylococcal bacteraemia 24.53 16.32 9 186750 11112 42423464
Respiratory symptom 24.48 16.32 9 186750 11097 42423479
Akinesia 24.41 16.32 41 186718 2431 42432145
Fistula 24.33 16.32 3 186756 7909 42426667
Tubulointerstitial nephritis 24.20 16.32 65 186694 31483 42403093
Dermatitis bullous 24.15 16.32 4 186755 8452 42426124
Blood disorder 24.14 16.32 54 186705 3963 42430613
Transient ischaemic attack 24.05 16.32 72 186687 33667 42400909
Seminoma 24.00 16.32 16 186743 312 42434264
Encephalitis toxic 23.93 16.32 15 186744 262 42434314
Musculoskeletal discomfort 23.92 16.32 6 186753 9470 42425106
Acidosis 23.80 16.32 12 186747 12267 42422309
Joint range of motion decreased 23.69 16.32 3 186756 7750 42426826
Ecchymosis 23.69 16.32 3 186756 7749 42426827
Stab wound 23.68 16.32 14 186745 219 42434357
Therapy non-responder 23.61 16.32 137 186622 53222 42381354
Bundle branch block left 23.42 16.32 72 186687 6404 42428172
Eyelid function disorder 23.37 16.32 13 186746 180 42434396
Ideas of reference 23.21 16.32 9 186750 50 42434526
Gamma-glutamyltransferase increased 23.18 16.32 231 186528 32266 42402310
Alcohol problem 23.16 16.32 10 186749 76 42434500
Large intestine polyp 23.13 16.32 6 186753 9259 42425317
Pseudophaeochromocytoma 23.09 16.32 7 186752 15 42434561
Quarantine 23.09 16.32 7 186752 15 42434561
Eye disorder 23.04 16.32 11 186748 11601 42422975
Physical assault 22.99 16.32 26 186733 1056 42433520
Epstein-Barr virus infection 22.95 16.32 7 186752 9711 42424865
Oral herpes 22.86 16.32 3 186756 7541 42427035
Pneumonia bacterial 22.86 16.32 21 186738 15671 42418905
Infection 22.83 16.32 648 186111 111420 42323156
Upper respiratory tract infection 22.80 16.32 101 186658 42072 42392504
Pyrexia 22.78 16.32 1455 185304 392587 42041989
Self-injurious ideation 22.60 16.32 34 186725 1834 42432742
Lymphocyte morphology abnormal 22.58 16.32 19 186740 533 42434043
Abdominal compartment syndrome 22.54 16.32 26 186733 1079 42433497
Product dispensing issue 22.51 16.32 14 186745 241 42434335
Stoma site extravasation 22.41 16.32 10 186749 83 42434493
Intentional overdose 22.36 16.32 333 186426 51123 42383453
Duodenal ulcer 22.34 16.32 13 186746 12266 42422310
Haemorrhagic stroke 22.30 16.32 3 186756 7399 42427177
Non-Hodgkin's lymphoma unspecified histology aggressive 22.17 16.32 5 186754 0 42434576
Respiratory distress 22.10 16.32 101 186658 41719 42392857
Sleep disorder 22.08 16.32 122 186637 47973 42386603
Rib fracture 22.05 16.32 24 186735 16547 42418029
Squamous cell carcinoma 21.90 16.32 15 186744 12967 42421609
Atrial flutter 21.85 16.32 26 186733 17225 42417351
Cerebrovascular accident 21.84 16.32 297 186462 96863 42337713
Generalised oedema 21.78 16.32 21 186738 15315 42419261
Drug level decreased 21.69 16.32 94 186665 9883 42424693
Cardiac death 21.67 16.32 26 186733 1126 42433450
Gastrointestinal obstruction 21.52 16.32 26 186733 1134 42433442
Systemic lupus erythematosus 21.51 16.32 7 186752 9317 42425259
Acne 21.41 16.32 17 186742 13627 42420949
Brain injury 21.37 16.32 78 186681 7577 42426999
Dermatitis acneiform 21.36 16.32 4 186755 7735 42426841
Electrocardiogram ST-T change 21.15 16.32 19 186740 583 42433993
Tonsillar exudate 21.15 16.32 6 186753 9 42434567
Needle issue 21.13 16.32 6 186753 8721 42425855
Judgement impaired 21.13 16.32 19 186740 584 42433992
Cognitive disorder 21.13 16.32 236 186523 33936 42400640
Nervousness 21.06 16.32 17 186742 13515 42421061
Mitral valve incompetence 21.03 16.32 134 186625 16355 42418221
Blood creatine phosphokinase decreased 20.99 16.32 19 186740 589 42433987
Joint injury 20.95 16.32 20 186739 14656 42419920
Chronic hepatitis C 20.92 16.32 18 186741 521 42434055
Drug monitoring procedure not performed 20.69 16.32 17 186742 461 42434115
Flank pain 20.68 16.32 4 186755 7559 42427017
Localised infection 20.59 16.32 36 186723 20337 42414239
Orthostatic hypertension 20.57 16.32 17 186742 465 42434111
Subacute endocarditis 20.56 16.32 9 186750 71 42434505
Mean cell haemoglobin concentration 20.55 16.32 8 186751 45 42434531
Thought blocking 20.51 16.32 11 186748 141 42434435
Ileus 20.51 16.32 149 186610 18990 42415586
Syringe issue 20.50 16.32 6 186753 8550 42426026
Brain neoplasm 20.37 16.32 47 186712 3521 42431055
Electroconvulsive therapy 20.30 16.32 7 186752 26 42434550
Acute hepatic failure 20.30 16.32 27 186732 17046 42417530
Gingival bleeding 20.24 16.32 6 186753 8479 42426097
Dermatitis allergic 20.23 16.32 6 186753 8477 42426099
Blood pressure fluctuation 20.22 16.32 56 186703 26852 42407724
Sinus rhythm 20.14 16.32 16 186743 413 42434163
Dyspepsia 20.03 16.32 103 186656 41249 42393327
ECG signs of myocardial ischaemia 20.01 16.32 12 186747 193 42434383
Prescribed underdose 20.00 16.32 10 186749 10272 42424304
Limb discomfort 19.92 16.32 16 186743 12751 42421825
Hemiplegia 19.87 16.32 5 186754 7874 42426702
Multiple-drug resistance 19.76 16.32 4 186755 7318 42427258
Hypertensive crisis 19.75 16.32 10 186749 10196 42424380
Mutism 19.71 16.32 28 186731 1434 42433142
Abdominal distension 19.66 16.32 210 186549 71525 42363051
Stupor 19.64 16.32 43 186716 3110 42431466
Empyema 19.55 16.32 51 186708 4129 42430447
Haematocrit increased 19.51 16.32 38 186721 2529 42432047
Manic symptom 19.48 16.32 12 186747 203 42434373
Patient elopement 19.42 16.32 11 186748 158 42434418
Hallucinations, mixed 19.34 16.32 45 186714 3390 42431186
Feeling cold 19.33 16.32 17 186742 12956 42421620
Intestinal ischaemia 19.31 16.32 87 186672 9301 42425275
Acute respiratory failure 19.27 16.32 96 186663 38762 42395814
Excessive masturbation 19.22 16.32 10 186749 120 42434456
Spinal osteoarthritis 19.21 16.32 7 186752 8679 42425897
Hypochromasia 19.19 16.32 14 186745 317 42434259
Haemolysis 19.15 16.32 9 186750 9580 42424996
Renal disorder 19.14 16.32 64 186695 28916 42405660
Microcytosis 19.12 16.32 12 186747 210 42434366
Heparin-induced thrombocytopenia 19.11 16.32 3 186756 6594 42427982
Pulmonary mass 19.06 16.32 26 186733 16239 42418337
Gastric infection 18.93 16.32 28 186731 1488 42433088
Rhinovirus infection 18.92 16.32 3 186756 6545 42428031
Somatic symptom disorder 18.86 16.32 20 186739 755 42433821
Retinal detachment 18.83 16.32 3 186756 6522 42428054
Somatic delusion 18.81 16.32 9 186750 89 42434487
Portal tract inflammation 18.73 16.32 10 186749 127 42434449
Testicular cancer metastatic 18.73 16.32 9 186750 90 42434486
Exposure during pregnancy 18.72 16.32 7 186752 8541 42426035
Drug use disorder 18.72 16.32 11 186748 10322 42424254
Suspected COVID-19 18.71 16.32 27 186732 1403 42433173
Tooth disorder 18.71 16.32 15 186744 11964 42422612
Rhinitis 18.70 16.32 15 186744 11962 42422614
Peripheral ischaemia 18.67 16.32 3 186756 6482 42428094
Monocyte percentage increased 18.53 16.32 23 186736 1032 42433544
Systolic dysfunction 18.53 16.32 41 186718 2987 42431589
Eye swelling 18.52 16.32 15 186744 11905 42422671
Immunosuppression 18.38 16.32 7 186752 8446 42426130
Somnolence neonatal 18.37 16.32 6 186753 18 42434558
Pulmonary embolism 18.31 16.32 392 186367 119220 42315356
Myocardial necrosis marker increased 18.30 16.32 31 186728 1851 42432725
Myopathy 18.23 16.32 20 186739 13741 42420835
Peritonitis bacterial 18.20 16.32 4 186755 6911 42427665
Irritability 18.19 16.32 196 186563 27932 42406644
Mean cell haemoglobin 18.13 16.32 6 186753 19 42434557
Unresponsive to stimuli 18.12 16.32 214 186545 31189 42403387
Arteriosclerosis coronary artery 18.10 16.32 142 186617 18535 42416041
Pulmonary pain 18.08 16.32 28 186731 1550 42433026
Red cell distribution width abnormal 18.04 16.32 7 186752 39 42434537
C-reactive protein abnormal 18.03 16.32 9 186750 9252 42425324
White blood cell disorder 17.83 16.32 31 186728 1890 42432686
Abdominal pain lower 17.83 16.32 16 186743 12076 42422500
Intentional medical device removal by patient 17.82 16.32 15 186744 421 42434155
Appendicectomy 17.79 16.32 27 186732 1468 42433108
High-grade B-cell lymphoma 17.76 16.32 11 186748 188 42434388
Blood cannabinoids 17.74 16.32 4 186755 0 42434576
Eating disorder 17.70 16.32 88 186671 9797 42424779
Heat stroke 17.63 16.32 23 186736 1085 42433491
Gender dysphoria 17.61 16.32 7 186752 42 42434534
Drop attacks 17.58 16.32 17 186742 574 42434002
Cardiac murmur 17.56 16.32 18 186741 12757 42421819
Right ventricular failure 17.55 16.32 10 186749 9545 42425031
Pollakiuria 17.54 16.32 46 186713 22459 42412117
Wound 17.52 16.32 30 186729 17087 42417489
Dialysis 17.51 16.32 16 186743 11970 42422606
Drug titration error 17.46 16.32 19 186740 739 42433837
Diarrhoea haemorrhagic 17.41 16.32 6 186753 7701 42426875
Torsade de pointes 17.27 16.32 8 186751 8586 42425990
Status epilepticus 17.17 16.32 26 186733 15552 42419024
Throat cancer 17.14 16.32 26 186733 1413 42433163
Blood bicarbonate decreased 17.13 16.32 39 186720 2896 42431680
Flat affect 17.08 16.32 22 186737 1025 42433551
Stoma site discomfort 17.06 16.32 6 186753 24 42434552
Coprolalia 17.06 16.32 6 186753 24 42434552
Compensatory sweating 17.06 16.32 6 186753 24 42434552
Hypophagia 17.04 16.32 187 186572 26769 42407807
Oral pain 17.03 16.32 18 186741 12578 42421998
Metastases to bone 17.02 16.32 24 186735 14785 42419791
Crush syndrome 17 16.32 8 186751 76 42434500
Blood bilirubin decreased 16.98 16.32 17 186742 599 42433977
Syncope 16.94 16.32 320 186439 99086 42335490
Aortic dilatation 16.91 16.32 28 186731 1641 42432935
Pickwickian syndrome 16.88 16.32 9 186750 114 42434462
Ankylosing spondylitis 16.81 16.32 5 186754 7051 42427525
Vascular dementia 16.80 16.32 16 186743 530 42434046
Protein total decreased 16.77 16.32 61 186698 5915 42428661
Basilar migraine 16.72 16.32 5 186754 10 42434566
Antidepressant therapy 16.72 16.32 5 186754 10 42434566
Catecholamines urine increased 16.72 16.32 5 186754 10 42434566
Sputum discoloured 16.70 16.32 12 186747 10120 42424456
Torticollis 16.67 16.32 25 186734 1345 42433231
Eosinophilic myocarditis 16.63 16.32 25 186734 1348 42433228
Testicular atrophy 16.62 16.32 17 186742 615 42433961
Mean cell haemoglobin concentration abnormal 16.58 16.32 7 186752 50 42434526
Stoma site irritation 16.55 16.32 10 186749 163 42434413
Hepatocellular injury 16.54 16.32 51 186708 23627 42410949
Peripheral coldness 16.51 16.32 8 186751 8367 42426209
Subileus 16.51 16.32 43 186716 3478 42431098
Supraventricular tachycardia 16.48 16.32 18 186741 12390 42422186
Conduction disorder 16.44 16.32 35 186724 2483 42432093
Pulmonary thrombosis 16.42 16.32 8 186751 8340 42426236

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 33143.19 16.95 15671 206935 358949 110007744
Neutrophilia 9734.50 16.95 2547 220059 7782 110358911
Neutrophil count increased 8301.77 16.95 2981 219625 31671 110335022
White blood cell count increased 6085.26 16.95 3241 219365 93601 110273092
Hospitalisation 5783.38 16.95 3586 219020 138907 110227786
Granulocytopenia 5381.19 16.95 1680 220926 11035 110355658
Differential white blood cell count abnormal 4276.18 16.95 979 221627 1305 110365388
Death 3478.51 16.95 5525 217081 693344 109673349
Myocarditis 3332.90 16.95 1485 221121 28570 110338123
Salivary hypersecretion 3280.52 16.95 1257 221349 16164 110350529
Antipsychotic drug level increased 3221.08 16.95 987 221619 6028 110360665
White blood cell count decreased 3111.12 16.95 3011 219595 226379 110140314
Neutrophil count decreased 2776.33 16.95 2146 220460 118795 110247898
Psychotic disorder 2376.49 16.95 1404 221202 49533 110317160
Agranulocytosis 2311.88 16.95 1479 221127 60281 110306412
Sedation 2045.97 16.95 1435 221171 68248 110298445
Leukopenia 1932.22 16.95 1909 220697 146882 110219811
Mental impairment 1704.65 16.95 857 221749 21782 110344911
Neuroleptic malignant syndrome 1670.52 16.95 970 221636 33089 110333604
Treatment noncompliance 1644.99 16.95 1282 221324 71708 110294985
Neutrophil count normal 1631.01 16.95 313 222293 0 110366693
Eosinophil count decreased 1546.08 16.95 546 222060 5472 110361221
Leukocytosis 1495.37 16.95 1072 221534 52756 110313937
Haemoglobin decreased 1263.16 16.95 1991 220615 246736 110119957
Hallucination, auditory 1257.95 16.95 738 221868 25659 110341034
Platelet count increased 1207.13 16.95 718 221888 25616 110341077
Tachycardia 1172.54 16.95 1830 220776 224815 110141878
Arthralgia 1148.14 16.95 119 222487 779513 109587180
Therapy interrupted 1081.04 16.95 856 221750 48966 110317727
Rash 1058.55 16.95 189 222417 820775 109545918
Pain 1057.97 16.95 307 222299 954648 109412045
Schizophrenia 971.53 16.95 584 222022 21242 110345451
Delusion 956.12 16.95 596 222010 23159 110343534
Dyskinesia 952.56 16.95 806 221800 50640 110316053
Pruritus 938.13 16.95 59 222547 581501 109785192
Headache 933.37 16.95 308 222298 882069 109484624
Anosognosia 901.44 16.95 331 222275 3743 110362950
Living in residential institution 892.70 16.95 237 222369 774 110365919
Antipsychotic drug level decreased 881.16 16.95 252 222354 1160 110365533
Dystonia 879.29 16.95 583 222023 25222 110341471
Haematocrit decreased 867.78 16.95 854 221752 65263 110301430
Nausea 862.03 16.95 736 221870 1234954 109131739
Monocyte count increased 850.08 16.95 451 222155 12842 110353851
Catatonia 848.25 16.95 427 222179 10873 110355820
Troponin increased 819.98 16.95 590 222016 29176 110337517
Blood prolactin abnormal 787.66 16.95 295 222311 3540 110363153
Joint swelling 775.19 16.95 26 222580 442819 109923874
Red blood cell count decreased 770.93 16.95 800 221806 65123 110301570
Antipsychotic drug level above therapeutic 753.27 16.95 254 222352 2186 110364507
Eosinophil count increased 749.69 16.95 489 222117 20569 110346124
Fatigue 743.52 16.95 814 221792 1215144 109151549
Disturbance in social behaviour 715.20 16.95 297 222309 4761 110361932
Diarrhoea 698.43 16.95 761 221845 1138744 109227949
Extrapyramidal disorder 691.39 16.95 526 222080 28341 110338352
Sexual dysfunction 680.64 16.95 336 222270 8194 110358499
Mean cell haemoglobin concentration decreased 678.65 16.95 296 222310 5386 110361307
Sinus tachycardia 663.97 16.95 617 221989 43876 110322817
Mean cell haemoglobin decreased 652.20 16.95 309 222297 6865 110359828
Drug hypersensitivity 645.65 16.95 78 222528 454012 109912681
Antipsychotic drug level below therapeutic 637.51 16.95 206 222400 1529 110365164
Eosinophilia 629.24 16.95 676 221930 57260 110309433
Swelling 605.89 16.95 23 222583 351018 110015675
Drug level increased 588.51 16.95 596 222010 47123 110319570
Pain in extremity 585.45 16.95 132 222474 486986 109879707
Suicide attempt 583.53 16.95 870 221736 102524 110264169
Drug interaction 573.67 16.95 2255 220351 497928 109868765
Metabolic disorder 573.33 16.95 321 222285 10189 110356504
Lymphocyte count decreased 571.46 16.95 639 221967 56604 110310089
Peripheral swelling 565.54 16.95 73 222533 403961 109962732
Rheumatoid arthritis 561.31 16.95 8 222598 299605 110067088
Faecaloma 552.32 16.95 355 222251 14553 110352140
Dyspnoea 551.69 16.95 862 221744 1106010 109260683
Lymphocyte count increased 543.01 16.95 273 222333 6930 110359763
Blood creatine phosphokinase increased 541.34 16.95 701 221905 72376 110294317
Hypersensitivity 524.08 16.95 91 222515 403907 109962786
Urticaria 523.86 16.95 29 222577 318828 110047865
C-reactive protein increased 512.86 16.95 1263 221343 216656 110150037
Mental disorder 512.49 16.95 503 222103 38288 110328405
Aggression 509 16.95 612 221994 58598 110308095
Stomatitis 507.15 16.95 7 222599 270235 110096458
Sinusitis 506.65 16.95 21 222585 296667 110070026
Alopecia 500.69 16.95 70 222536 364683 110002010
Personality change 493.75 16.95 296 222310 10706 110355987
Red cell distribution width increased 489.57 16.95 351 222255 17251 110349442
Akathisia 479.98 16.95 343 222263 16770 110349923
Psychotic symptom 466.88 16.95 203 222403 3664 110363029
Systemic lupus erythematosus 459.28 16.95 11 222595 254327 110112366
Paranoia 458.72 16.95 372 222234 22002 110344691
Abdominal discomfort 456.81 16.95 115 222491 393743 109972950
Electrocardiogram QT prolonged 454.03 16.95 799 221807 108161 110258532
Pneumonia aspiration 448.97 16.95 677 221929 80556 110286137
Psychiatric decompensation 447.85 16.95 223 222383 5542 110361151
Benign ethnic neutropenia 447.53 16.95 91 222515 31 110366662
Platelet count decreased 441.53 16.95 1237 221369 229206 110137487
Agitation 440.37 16.95 805 221801 112246 110254447
Arthropathy 437.93 16.95 38 222568 287484 110079209
Gastrointestinal hypomotility 432.95 16.95 170 222436 2338 110364355
Glossodynia 429.31 16.95 3 222603 222001 110144692
Pre-existing disease 428.89 16.95 97 222509 117 110366576
Somnolence 422.28 16.95 1438 221168 296011 110070682
Hypoaesthesia 415.81 16.95 67 222539 314156 110052537
Obsessive-compulsive disorder 413.68 16.95 228 222378 7013 110359680
Drooling 411.19 16.95 226 222380 6913 110359780
Drug intolerance 406.38 16.95 155 222451 406357 109960336
Erythema 404.48 16.95 54 222552 291393 110075300
Nasopharyngitis 403.24 16.95 145 222461 394216 109972477
Back pain 392.12 16.95 129 222477 370867 109995826
Mean cell volume decreased 391.74 16.95 203 222403 5499 110361194
Blister 388.47 16.95 16 222590 227360 110139333
Overdose 380.15 16.95 1184 221422 232610 110134083
Wound 376.86 16.95 24 222582 234413 110132280
Impaired healing 369.46 16.95 5 222601 196712 110169981
Abdominal pain upper 362.65 16.95 125 222481 348986 110017707
Asthenia 361.44 16.95 517 222089 688482 109678211
Tardive dyskinesia 357.64 16.95 262 222344 13317 110353376
Schizoaffective disorder 357.14 16.95 158 222448 2978 110363715
Paraesthesia 354.73 16.95 64 222542 276457 110090236
Helicobacter infection 348.99 16.95 3 222603 181874 110184819
Orthostatic hypotension 348.95 16.95 540 222066 65709 110300984
Intentional product use issue 343.81 16.95 46 222560 247860 110118833
Wheezing 338.58 16.95 54 222552 255176 110111517
Febrile neutropenia 334.95 16.95 110 222496 316657 110050036
Abnormal behaviour 334.64 16.95 403 222203 38636 110328057
Mean cell volume increased 327.59 16.95 206 222400 8124 110358569
Therapeutic product effect decreased 325.65 16.95 51 222555 244265 110122428
Muscle rigidity 323.73 16.95 315 222291 23716 110342977
Discomfort 322.52 16.95 30 222576 214677 110152016
Fibromyalgia 322.47 16.95 4 222602 170905 110195788
Folliculitis 320.55 16.95 3 222603 167650 110199043
Imprisonment 315.51 16.95 99 222507 660 110366033
Musculoskeletal pain 312.22 16.95 13 222593 183010 110183683
Decreased appetite 311.71 16.95 299 222307 475547 109891146
Parkinsonism 310.51 16.95 297 222309 21890 110344803
Osteoarthritis 301.73 16.95 16 222590 182607 110184086
Oedema peripheral 294.05 16.95 147 222459 328513 110038180
Intestinal obstruction 288.95 16.95 440 222166 52787 110313906
Myoclonus 288.34 16.95 344 222262 32654 110334039
Malignant neoplasm progression 286.21 16.95 16 222590 174551 110192142
Cardiomyopathy 283.95 16.95 344 222262 33181 110333512
Muscle spasms 282.99 16.95 103 222503 278054 110088639
Maternal exposure during pregnancy 277.47 16.95 84 222522 254799 110111894
Injection site pain 275.02 16.95 22 222584 177900 110188793
Arthritis 272.79 16.95 16 222590 167570 110199123
Hepatic enzyme increased 270.24 16.95 155 222451 320737 110045956
Enuresis 267.61 16.95 141 222465 3955 110362738
Therapy cessation 266.72 16.95 387 222219 44470 110322223
Gastrointestinal disorder 266.54 16.95 78 222528 241874 110124819
Acute kidney injury 265.24 16.95 551 222055 634879 109731814
Contusion 264.94 16.95 71 222535 233290 110133403
Ileus paralytic 261.64 16.95 205 222401 11532 110355161
Wrong patient received product 259.82 16.95 164 222442 6510 110360183
Troponin T increased 252.64 16.95 138 222468 4168 110362525
Withdrawal catatonia 249.38 16.95 72 222534 345 110366348
Intestinal pseudo-obstruction 246.54 16.95 125 222481 3231 110363462
Seizure 246.23 16.95 989 221617 220196 110146497
Migraine 242.43 16.95 30 222576 171622 110195071
Irritable bowel syndrome 241.21 16.95 25 222581 164190 110202503
Cough 230.50 16.95 358 222248 461283 109905410
Joint range of motion decreased 229.16 16.95 3 222603 121829 110244864
Hallucination 227.96 16.95 578 222028 100854 110265839
Disease progression 226.10 16.95 104 222502 243930 110122763
Oedema 225.28 16.95 71 222535 209905 110156788
Hyperprolactinaemia 222.60 16.95 148 222458 6427 110360266
On and off phenomenon 222.11 16.95 128 222478 4296 110362397
Generalised tonic-clonic seizure 221.26 16.95 396 222210 54284 110312409
Lung neoplasm malignant 217.46 16.95 303 222303 33539 110333154
Blood glucose increased 217.01 16.95 673 221933 131823 110234870
Choking 216.64 16.95 205 222401 14905 110351788
Muscle injury 215.97 16.95 18 222588 140789 110225904
Persecutory delusion 211.52 16.95 141 222465 6150 110360543
Constipation 200.14 16.95 1319 221287 356467 110010226
Pleurothotonus 198.10 16.95 98 222508 2400 110364293
Oculogyric crisis 198.08 16.95 113 222493 3719 110362974
Asthma 198.02 16.95 130 222476 250161 110116532
Ill-defined disorder 195.34 16.95 39 222567 156814 110209879
Dry mouth 193.46 16.95 80 222526 199868 110166825
C-reactive protein abnormal 192.41 16.95 19 222587 129676 110237017
Blood prolactin increased 190.61 16.95 118 222488 4524 110362169
Refusal of examination 190.10 16.95 52 222554 196 110366497
Muscular weakness 189.96 16.95 134 222472 248334 110118359
Inappropriate schedule of product administration 189.84 16.95 86 222520 203551 110163142
Delirium 188.00 16.95 649 221957 134376 110232317
Musculoskeletal stiffness 186.38 16.95 173 222433 279649 110087044
Anaphylactic reaction 182.74 16.95 12 222594 114288 110252405
Psoriasis 178.16 16.95 33 222573 139960 110226733
Neuropathy peripheral 177.91 16.95 69 222537 179208 110187485
Immature granulocyte count increased 176.26 16.95 66 222540 791 110365902
Epistaxis 174.15 16.95 27 222579 130345 110236348
Pericardial effusion 172.48 16.95 366 222240 56851 110309842
Psychiatric symptom 171.78 16.95 145 222461 9068 110357625
Sciatica 170.69 16.95 3 222603 92396 110274297
Delusion of grandeur 168.42 16.95 85 222521 2175 110364518
Aspiration 167.96 16.95 254 222352 30279 110336414
Treatment failure 165.81 16.95 188 222418 277046 110089647
Dyspepsia 165.38 16.95 89 222517 190876 110175817
Injury 165.02 16.95 75 222531 177190 110189503
No adverse event 163.01 16.95 418 222188 73421 110293272
Mobility decreased 161.42 16.95 144 222462 237278 110129415
Haematochezia 161.14 16.95 21 222585 115503 110251190
Liver injury 161.07 16.95 51 222555 150362 110216331
Megacolon 160.65 16.95 103 222503 4202 110362491
Hypertension 160.48 16.95 510 222096 509574 109857119
Haemoglobin increased 160.43 16.95 139 222467 9008 110357685
Suicidal ideation 158.31 16.95 482 222124 93455 110273238
Neck pain 156.74 16.95 29 222577 123101 110243592
Hyperkalaemia 156.59 16.95 40 222566 135756 110230937
Injection site reaction 156.46 16.95 5 222601 89065 110277628
Thrombocytopenia 156.11 16.95 1219 221387 347666 110019027
Neoplasm malignant 155.42 16.95 273 222333 36870 110329823
Interstitial lung disease 155.09 16.95 44 222562 139290 110227403
Mean platelet volume increased 154.77 16.95 72 222534 1532 110365161
Sudden death 154.62 16.95 217 222389 24178 110342515
Sopor 152.13 16.95 268 222338 36278 110330415
Night sweats 151.58 16.95 41 222565 133942 110232751
Left ventricular hypertrophy 149.85 16.95 158 222448 13086 110353607
Basophil count increased 149.48 16.95 73 222533 1737 110364956
Lung disorder 148.62 16.95 89 222517 179958 110186735
Dizziness 148.20 16.95 813 221793 697380 109669313
Vomiting 147.97 16.95 1150 221456 909525 109457168
Exposure during pregnancy 147.97 16.95 76 222530 167348 110199345
Neutrophil count abnormal 146.52 16.95 104 222502 5028 110361665
Herpes zoster 143.50 16.95 23 222583 108356 110258337
Ileus 143.28 16.95 237 222369 30492 110336201
Dry skin 142.19 16.95 23 222583 107630 110259063
Rash pruritic 141.28 16.95 16 222590 98053 110268640
Red blood cell count increased 141.19 16.95 100 222506 4818 110361875
Blood triglycerides increased 140.15 16.95 205 222401 23721 110342972
Left ventricular dysfunction 140.10 16.95 203 222403 23290 110343403
Pulmonary fibrosis 138.89 16.95 20 222586 102022 110264671
Toxicity to various agents 138.61 16.95 1528 221078 479027 109887666
Abdominal pain 137.94 16.95 548 222058 512441 109854252
Gastrooesophageal reflux disease 137.62 16.95 97 222509 179879 110186814
Thinking abnormal 137.50 16.95 161 222445 14979 110351714
Rectal haemorrhage 136.83 16.95 36 222570 119797 110246896
Wound infection 135.84 16.95 17 222589 96448 110270245
Grip strength decreased 135.69 16.95 6 222600 80168 110286525
Myalgia 134.93 16.95 149 222457 222232 110144461
Weight decreased 134.25 16.95 487 222119 467570 109899123
Peripheral venous disease 133.97 16.95 9 222597 84108 110282585
Monocyte count decreased 133.56 16.95 88 222518 3763 110362930
Freezing phenomenon 132.35 16.95 76 222530 2533 110364160
Terminal state 130.69 16.95 101 222505 5566 110361127
Mean cell haemoglobin concentration increased 130.42 16.95 57 222549 1042 110365651
Insomnia 129.08 16.95 339 222267 360251 110006442
Electrocardiogram T wave abnormal 128.65 16.95 89 222517 4128 110362565
Psychiatric evaluation 128.51 16.95 26 222580 8 110366685
Bronchitis 127.68 16.95 79 222527 156953 110209740
Atrial fibrillation 127.47 16.95 165 222441 229477 110137216
Gait inability 126.45 16.95 58 222548 136318 110230375
General physical condition abnormal 126.41 16.95 112 222494 7478 110359215
Electroencephalogram abnormal 125.18 16.95 102 222504 6071 110360622
Myelosuppression 124.95 16.95 20 222586 94320 110272373
Cytokine release syndrome 123.30 16.95 4 222602 70302 110296391
Rebound psychosis 123.08 16.95 42 222564 376 110366317
Chills 122.01 16.95 122 222484 190458 110176235
Investigation noncompliance 121.82 16.95 26 222580 18 110366675
Hypothermia 121.48 16.95 202 222404 26100 110340593
Troponin I increased 121.03 16.95 95 222511 5357 110361336
Apathy 120.53 16.95 156 222450 16083 110350610
Fluid retention 120.48 16.95 22 222584 94285 110272408
Cholinergic rebound syndrome 120.32 16.95 28 222578 42 110366651
Thrombosis 119.67 16.95 35 222571 108627 110258066
Blood urea decreased 119.21 16.95 79 222527 3411 110363282
Mania 118.66 16.95 176 222430 20620 110346073
Live birth 118.25 16.95 5 222601 69479 110297214
Dysphemia 118.01 16.95 83 222523 3954 110362739
Hypokalaemia 117.71 16.95 116 222490 182332 110184361
Lung cancer metastatic 115.09 16.95 83 222523 4115 110362578
Drug monitoring procedure incorrectly performed 114.16 16.95 47 222559 736 110365957
Nasal congestion 113.21 16.95 29 222577 98253 110268440
Visual impairment 112.98 16.95 65 222541 134363 110232330
Circulatory collapse 112.63 16.95 260 222346 42733 110323960
Urinary incontinence 112.40 16.95 280 222326 48307 110318386
Refusal of treatment by patient 112.32 16.95 116 222490 9378 110357315
Liver disorder 112.30 16.95 74 222532 142169 110224524
Metabolic syndrome 112.13 16.95 74 222532 3173 110363520
High density lipoprotein decreased 110.54 16.95 92 222514 5641 110361052
Frequent bowel movements 109.81 16.95 9 222597 71381 110295312
Skin exfoliation 108.69 16.95 22 222584 87629 110279064
Taste disorder 107.13 16.95 6 222600 65381 110301312
Swelling face 106.81 16.95 27 222579 92294 110274399
Electrocardiogram abnormal 106.27 16.95 158 222448 18551 110348142
Congestive cardiomyopathy 106.17 16.95 137 222469 14082 110352611
Mean cell haemoglobin increased 105.95 16.95 89 222517 5528 110361165
Bundle branch block right 105.50 16.95 127 222479 12164 110354529
Off label use 104.92 16.95 2264 220342 1497921 108868772
Chest discomfort 104.88 16.95 117 222489 173731 110192962
Wrong patient 104.79 16.95 54 222552 1445 110365248
Schizoaffective disorder bipolar type 102.45 16.95 34 222572 277 110366416
Posture abnormal 102.14 16.95 79 222527 4359 110362334
Polydipsia 102.08 16.95 100 222506 7588 110359105
Dysgeusia 101.86 16.95 11 222595 69974 110296719
Osteoporosis 101.77 16.95 25 222581 87127 110279566
Lymphoma 101.43 16.95 161 222445 20010 110346683
Colitis ulcerative 101.12 16.95 17 222589 77346 110289347
International normalised ratio increased 101.12 16.95 25 222581 86747 110279946
Sleep disorder 100.97 16.95 152 222454 198492 110168201
Myocardial fibrosis 100.90 16.95 58 222548 1937 110364756
Dysarthria 100.67 16.95 385 222221 83736 110282957
Liver function test increased 100.33 16.95 27 222579 88521 110278172
Dyspnoea exertional 100.04 16.95 42 222564 104018 110262675
Rhinorrhoea 99.40 16.95 41 222565 102625 110264068
Pulmonary valve incompetence 97.11 16.95 63 222543 2623 110364070
Joint stiffness 96.78 16.95 11 222595 67232 110299461
Colitis ischaemic 96.68 16.95 147 222459 17603 110349090
Product quality issue 96.68 16.95 19 222587 77280 110289413
Acute psychosis 96.10 16.95 80 222526 4907 110361786
Intentional self-injury 95.47 16.95 224 222382 37205 110329488
Malignant catatonia 94.92 16.95 40 222566 666 110366027
Tinnitus 94.89 16.95 7 222599 60533 110306160
Stoma site discharge 94.82 16.95 63 222543 2732 110363961
Dementia 94.75 16.95 202 222404 31471 110335222
Condition aggravated 94.63 16.95 984 221622 733852 109632841
Affective disorder 94.61 16.95 115 222491 11126 110355567
QRS axis abnormal 94.46 16.95 60 222546 2408 110364285
Therapeutic product effect variable 93.99 16.95 62 222544 2656 110364037
Feeling hot 93.84 16.95 33 222573 91073 110275620
Gastrointestinal haemorrhage 93.84 16.95 117 222489 165401 110201292
Behaviour disorder 93.34 16.95 106 222500 9541 110357152
Depression 93.03 16.95 327 222279 317008 110049685
Social avoidant behaviour 92.97 16.95 81 222525 5288 110361405
Disinhibition 92.93 16.95 65 222541 3069 110363624
Rash erythematous 92.63 16.95 25 222581 81807 110284886
Bradykinesia 91.83 16.95 111 222495 10677 110356016
Swollen tongue 91.77 16.95 8 222598 60354 110306339
Loss of personal independence in daily activities 91.55 16.95 100 222506 149920 110216773
Angioedema 91.14 16.95 42 222564 98458 110268235
Mutism 90.99 16.95 64 222542 3049 110363644
Coma 90.73 16.95 473 222133 117396 110249297
Prescribed underdose 90.52 16.95 12 222594 65162 110301531
Bone pain 90.45 16.95 12 222594 65121 110301572
Lymphocyte count abnormal 90.42 16.95 58 222548 2368 110364325
Hallucination, visual 89.26 16.95 226 222380 39379 110327314
Volvulus 88.41 16.95 66 222540 3452 110363241
Haematocrit increased 88.27 16.95 76 222530 4883 110361810
Flushing 87.50 16.95 51 222555 104685 110262008
Psychotic behaviour 87.30 16.95 47 222559 1378 110365315
Cytomegalovirus infection 86.19 16.95 6 222600 54438 110312255
Hepatitis C 85.93 16.95 116 222490 12457 110354236
Tobacco interaction 85.55 16.95 25 222581 126 110366567
Suspiciousness 85.27 16.95 38 222568 729 110365964
Lactic acidosis 85.22 16.95 40 222566 92771 110273922
Ascites 85.21 16.95 40 222566 92768 110273925
Throat irritation 84.49 16.95 6 222600 53546 110313147
Eye pain 83.96 16.95 4 222602 50095 110316598
Mouth ulceration 83.49 16.95 3 222603 48135 110318558
Cataract 83.23 16.95 28 222578 79457 110287236
Dry eye 83.20 16.95 8 222598 55785 110310908
Eosinopenia 81.47 16.95 23 222583 100 110366593
Stevens-Johnson syndrome 81.08 16.95 3 222603 46898 110319795
Drug ineffective 80.56 16.95 2390 220216 1518150 108848543
Gastrointestinal necrosis 80.13 16.95 82 222524 6558 110360135
Blood pressure increased 79.97 16.95 260 222346 258113 110108580
Drug dose titration not performed 79.20 16.95 40 222566 1025 110365668
Hot flush 78.97 16.95 18 222588 66018 110300675
Burning sensation 78.61 16.95 21 222585 69191 110297502
Psychomotor hyperactivity 78.39 16.95 144 222462 20133 110346560
Hip arthroplasty 78.18 16.95 10 222596 55803 110310890
Impaired self-care 77.95 16.95 54 222552 2510 110364183
Stoma site erythema 77.39 16.95 50 222556 2067 110364626
Inflammation 76.72 16.95 172 222434 193066 110173627
Polydipsia psychogenic 76.45 16.95 28 222578 314 110366379
Rash maculo-papular 76.24 16.95 27 222579 74195 110292498
Hyperkinesia 76.17 16.95 58 222548 3126 110363567
Monocytosis 75.97 16.95 46 222560 1694 110364999
Back injury 75.68 16.95 5 222601 47394 110319299
Road traffic accident 75.56 16.95 63 222543 107335 110259358
Intellectual disability 75.46 16.95 48 222558 1931 110364762
Neutrophil count 75.32 16.95 29 222577 377 110366316
Subileus 74.98 16.95 78 222528 6359 110360334
COVID-19 74.12 16.95 787 221819 244273 110122420
Blepharospasm 74.06 16.95 11 222595 54840 110311853
Ejection fraction decreased 73.82 16.95 215 222391 40665 110326028
Intestinal dilatation 73.79 16.95 60 222546 3560 110363133
Hypomagnesaemia 73.10 16.95 16 222590 60354 110306339
Multiple sclerosis relapse 72.85 16.95 8 222598 50232 110316461
Neuralgia 72.16 16.95 7 222599 48471 110318222
Pain in jaw 72.10 16.95 9 222597 51168 110315525
Hypocalcaemia 72.07 16.95 21 222585 65345 110301348
Gamma-glutamyltransferase increased 72.05 16.95 279 222327 61030 110305663
Electrocardiogram T wave inversion 71.93 16.95 72 222534 5608 110361085
Haematoma 71.83 16.95 15 222591 58461 110308232
Sedation complication 71.76 16.95 137 222469 19718 110346975
Diverticulitis 71.66 16.95 11 222595 53511 110313182
Basal cell carcinoma 71.63 16.95 5 222601 45265 110321428
Haemoptysis 71.53 16.95 27 222579 71327 110295366
Knee arthroplasty 71.36 16.95 21 222585 64927 110301766
Hypoglycaemia 71.27 16.95 77 222529 116027 110250666
Vision blurred 71.26 16.95 93 222513 128929 110237764
Intentional overdose 70.65 16.95 483 222123 132018 110234675
Autoimmune disorder 70.45 16.95 22 222584 65461 110301232
Nephrolithiasis 69.90 16.95 23 222583 66189 110300504
Upper respiratory tract infection 69.17 16.95 98 222508 131230 110235463
Euphoric mood 68.98 16.95 87 222519 8740 110357953
Product use issue 68.71 16.95 358 222248 311337 110055356
Polyserositis 68.70 16.95 36 222570 998 110365695
Waxy flexibility 68.69 16.95 25 222581 275 110366418
Productive cough 67.76 16.95 78 222528 114227 110252466
Body temperature increased 67.60 16.95 253 222353 54460 110312233
Withdrawal syndrome 67.55 16.95 176 222430 31204 110335489
Renal failure 67.37 16.95 232 222374 226342 110140351
Ear pain 66.74 16.95 13 222593 53213 110313480
Laryngitis 66.20 16.95 5 222601 42406 110324287
Metamyelocyte count increased 65.98 16.95 31 222575 675 110366018
Postmortem blood drug level increased 65.91 16.95 37 222569 1180 110365513
Restlessness 65.28 16.95 255 222351 56004 110310689
Renal impairment 65.23 16.95 180 222426 188265 110178428
Echocardiogram abnormal 64.61 16.95 49 222557 2625 110364068
Cerebral haemorrhage 64.44 16.95 25 222581 64943 110301750
Lip swelling 64.33 16.95 12 222594 50655 110316038
Skin lesion 63.92 16.95 13 222593 51618 110315075
Eczema 63.58 16.95 33 222573 72260 110294433
Lymphocyte percentage increased 63.57 16.95 32 222574 814 110365879
Hepatotoxicity 63.54 16.95 24 222582 63376 110303317
Thrombocytosis 63.37 16.95 91 222515 10353 110356340
Hypercholesterolaemia 63.02 16.95 54 222552 90783 110275910
Toxic epidermal necrolysis 62.95 16.95 18 222588 56709 110309984
Obsessive-compulsive symptom 62.83 16.95 24 222582 305 110366388
Small intestinal obstruction 62.63 16.95 174 222432 32039 110334654
Anion gap increased 62.39 16.95 59 222547 4285 110362408
Head titubation 62.16 16.95 37 222569 1320 110365373
Blood cholesterol increased 62.12 16.95 179 222427 184606 110182087
Delusional disorder, unspecified type 62.01 16.95 32 222574 859 110365834
Blood pressure systolic increased 61.76 16.95 46 222560 82945 110283748
Mental status changes 61.02 16.95 309 222297 75813 110290880
X-ray abnormal 60.92 16.95 4 222602 38113 110328580
Coma scale abnormal 60.86 16.95 86 222520 9640 110357053
Negativism 60.75 16.95 32 222574 897 110365796
Blood bilirubin decreased 60.20 16.95 37 222569 1400 110365293
Oral herpes 60.08 16.95 3 222603 36077 110330616
Tremor 59.99 16.95 647 221959 201585 110165108
Memory impairment 59.68 16.95 200 222406 196744 110169949
Depressed level of consciousness 59.09 16.95 408 222198 111870 110254823
Procedural pain 59.08 16.95 3 222603 35562 110331131
Pregnancy 58.94 16.95 15 222591 51052 110315641
Heart rate decreased 58.89 16.95 48 222558 82708 110283985
Disorientation 58.86 16.95 290 222316 70381 110296312
Haemorrhage 58.82 16.95 77 222529 106615 110260078
Tonic clonic movements 58.23 16.95 48 222558 2904 110363789
Amnesia 58.19 16.95 76 222530 105332 110261361
Blood osmolarity increased 57.94 16.95 30 222576 811 110365882
Dysphonia 57.92 16.95 41 222565 75888 110290805
Pseudophaeochromocytoma 57.75 16.95 18 222588 117 110366576
Priapism 57.73 16.95 65 222541 5796 110360897
Candida infection 57.58 16.95 13 222593 47996 110318697
Body mass index increased 56.97 16.95 43 222563 2287 110364406
Akinesia 56.91 16.95 52 222554 3615 110363078
Cystitis 56.82 16.95 31 222575 66005 110300688
Tricuspid valve incompetence 56.71 16.95 139 222467 23734 110342959
Posterior reversible encephalopathy syndrome 55.80 16.95 3 222603 33858 110332835
Irritability 55.71 16.95 217 222389 47592 110319101
Neutrophil percentage decreased 54.71 16.95 30 222576 913 110365780
Foreign body ingestion 54.67 16.95 11 222595 3 110366690
Globulins decreased 54.62 16.95 28 222578 741 110365952
Haematuria 54.42 16.95 52 222554 82953 110283740
Hypervolaemia 54.32 16.95 16 222590 49444 110317249
Finger deformity 54.32 16.95 3 222603 33089 110333604
Overweight 54.19 16.95 66 222540 6398 110360295
Joint injury 54.05 16.95 8 222598 39986 110326707
Therapeutic product effect incomplete 53.96 16.95 249 222357 223556 110143137
Feeling abnormal 53.74 16.95 185 222421 180526 110186167
Mucosal inflammation 53.40 16.95 69 222537 96072 110270621
Cardiac failure congestive 53.18 16.95 143 222463 150857 110215836
Palpitations 52.95 16.95 155 222451 159057 110207636
Myelocyte count increased 52.81 16.95 29 222577 885 110365808
Bradycardia 52.75 16.95 150 222456 155367 110211326
Cogwheel rigidity 52.68 16.95 50 222556 3648 110363045
Drug eruption 52.64 16.95 21 222585 53638 110313055
Apraxia 52.61 16.95 49 222557 3491 110363202
Drug-induced liver injury 52.61 16.95 101 222505 119966 110246727
Cholinergic syndrome 52.52 16.95 33 222573 1299 110365394
Bronchiectasis 52.44 16.95 6 222600 36487 110330206
Pneumocystis jirovecii pneumonia 52.41 16.95 11 222595 42724 110323969
Arteriosclerosis coronary artery 52.15 16.95 139 222467 24979 110341714
Basophil count decreased 52.01 16.95 23 222583 433 110366260
Pancytopenia 51.85 16.95 231 222375 209382 110157311
Skin discolouration 51.84 16.95 17 222589 49029 110317664
Haemophagocytic lymphohistiocytosis 51.38 16.95 3 222603 31556 110335137
Fungal infection 51.30 16.95 19 222587 50787 110315906
Angina pectoris 51.09 16.95 31 222575 62264 110304429
Diabetes mellitus 51.04 16.95 359 222247 99022 110267671
Loss of consciousness 50.99 16.95 612 221994 195694 110170999
Diplopia 50.94 16.95 11 222595 41883 110324810
Haemorrhoids 50.92 16.95 6 222600 35666 110331027
Monocyte percentage increased 50.84 16.95 40 222566 2263 110364430
Coronavirus infection 50.51 16.95 78 222528 9467 110357226
Electrocardiogram ST segment elevation 50.09 16.95 76 222530 9084 110357609
Lethargy 49.81 16.95 341 222265 93235 110273458
Mitral valve incompetence 49.70 16.95 164 222442 33165 110333528
Personality change due to a general medical condition 49.66 16.95 20 222586 295 110366398
Gastrointestinal carcinoma 49.56 16.95 47 222559 3426 110363267
B-cell lymphoma 48.89 16.95 66 222540 7088 110359605
Anisocytosis 48.09 16.95 30 222576 1166 110365527
Blunted affect 48.04 16.95 23 222583 523 110366170
Mean platelet volume decreased 47.74 16.95 45 222561 3255 110363438
Drug reaction with eosinophilia and systemic symptoms 47.61 16.95 57 222549 82038 110284655
Product dispensing error 47.46 16.95 103 222503 16242 110350451
Product use in unapproved indication 47.43 16.95 625 221981 446752 109919941
Coeliac disease 47.38 16.95 14 222592 43173 110323520
Blood sodium increased 47.29 16.95 57 222549 5466 110361227
SARS-CoV-2 test positive 47.23 16.95 105 222501 16830 110349863
Throat tightness 46.90 16.95 6 222600 33483 110333210
Device related infection 46.80 16.95 11 222595 39508 110327185
Cardiac disorder 46.73 16.95 288 222318 75992 110290701
Pneumonitis 46.70 16.95 51 222555 76480 110290213
Muscle spasticity 46.69 16.95 8 222598 35907 110330786
Increased appetite 46.51 16.95 97 222509 14880 110351813
Sinus congestion 46.40 16.95 4 222602 30455 110336238
Leukaemia 46.34 16.95 66 222540 7452 110359241
Neutrophil percentage increased 45.87 16.95 53 222553 4860 110361833
Gout 45.70 16.95 9 222597 36557 110330136
Protein total decreased 45.50 16.95 80 222526 10810 110355883
Blood alkaline phosphatase increased 45.47 16.95 271 222335 70664 110296029
Chronic obstructive pulmonary disease 45.24 16.95 375 222231 108783 110257910
Melaena 45.16 16.95 43 222563 68714 110297979
Drug level decreased 45.13 16.95 109 222497 18439 110348254
Osteonecrosis 45.02 16.95 7 222599 33734 110332959
Cardiomegaly 44.93 16.95 145 222461 28985 110337708
Torticollis 44.84 16.95 43 222563 3178 110363515
Clostridium difficile colitis 44.84 16.95 16 222590 43762 110322931
Delusional disorder, persecutory type 44.79 16.95 23 222583 611 110366082
Adverse reaction 44.77 16.95 4 222602 29590 110337103
Oral candidiasis 44.76 16.95 17 222589 44743 110321950
Blood osmolarity decreased 44.63 16.95 31 222575 1447 110365246
Device expulsion 44.59 16.95 5 222601 30886 110335807
Ocular hyperaemia 44.46 16.95 12 222594 39274 110327419
Fibroma 44.33 16.95 27 222579 1005 110365688
Contraindicated product administered 44.22 16.95 305 222301 247962 110118731
Lymphadenopathy 44.22 16.95 38 222568 63797 110302896
Hypersensitivity myocarditis 44.15 16.95 19 222587 334 110366359
Clostridium difficile infection 44.09 16.95 25 222581 52104 110314589
Radiation inflammation 43.94 16.95 27 222579 1021 110365672
Underdose 43.82 16.95 38 222568 63516 110303177
Incoherent 43.81 16.95 68 222538 8290 110358403
Obstructive airways disorder 43.75 16.95 19 222587 46130 110320563
Ulcer 43.75 16.95 16 222590 43100 110323593
Abdominal compartment syndrome 43.69 16.95 34 222572 1893 110364800
Toxic skin eruption 43.64 16.95 3 222603 27512 110339181
Vertigo 43.61 16.95 67 222539 86803 110279890
Breast cancer stage II 43.38 16.95 3 222603 27372 110339321
Lupus-like syndrome 43.36 16.95 14 222592 40778 110325915
Blood creatinine decreased 43.30 16.95 71 222535 9066 110357627
Palliative care 43.30 16.95 32 222574 1648 110365045
Blindness 43.29 16.95 10 222596 36349 110330344
Shock haemorrhagic 43.13 16.95 3 222603 27244 110339449
Nodule 43.02 16.95 7 222599 32624 110334069
Inappropriate affect 42.98 16.95 32 222574 1667 110365026
Rhabdomyolysis 42.84 16.95 400 222206 120001 110246692
Eosinophilic pleural effusion 42.72 16.95 21 222585 507 110366186
Bronchopulmonary aspergillosis 42.68 16.95 5 222601 29858 110336835
Ear infection 42.66 16.95 38 222568 62694 110303999
Ventricular hypokinesia 42.54 16.95 79 222527 11135 110355558
Ventricular tachycardia 42.27 16.95 24 222582 49985 110316708
Reduced facial expression 42.10 16.95 44 222562 3607 110363086
Dehydration 41.98 16.95 360 222246 279151 110087542
Systolic dysfunction 41.85 16.95 48 222558 4367 110362326
Plasma cell myeloma 41.75 16.95 39 222567 62897 110303796
Stoma site inflammation 41.71 16.95 26 222580 1009 110365684
Rebound effect 41.51 16.95 92 222514 14714 110351979
Eosinophilic myocarditis 41.33 16.95 34 222572 2051 110364642
Dyslipidaemia 41.21 16.95 96 222510 15869 110350824
Blood albumin decreased 41.18 16.95 136 222470 27516 110339177
Haemorrhage intracranial 41.04 16.95 5 222601 28964 110337729
Follicular lymphoma stage IV 40.96 16.95 11 222595 38 110366655
Hepatitis C virus test positive 40.94 16.95 19 222587 402 110366291
Obsessive thoughts 40.85 16.95 28 222578 1279 110365414
Faecal vomiting 40.75 16.95 30 222576 1536 110365157
Pancreatic fibrosis 40.52 16.95 13 222593 94 110366599
Unresponsive to stimuli 40.44 16.95 243 222363 63547 110303146
Skin ulcer 40.42 16.95 41 222565 63604 110303089
Blood pressure diastolic abnormal 40.41 16.95 3 222603 25812 110340881
Judgement impaired 40.41 16.95 28 222578 1302 110365391
Blood bicarbonate decreased 40.40 16.95 54 222552 5743 110360950
Nervousness 40.33 16.95 12 222594 36839 110329854
Visual acuity reduced 40.04 16.95 8 222598 32165 110334528
Bipolar disorder 40.03 16.95 68 222538 8939 110357754
Lacrimation increased 40.00 16.95 7 222599 30943 110335750
Limb injury 39.85 16.95 13 222593 37623 110329070
Hypophagia 39.66 16.95 210 222396 52416 110314277
Hepatic failure 39.57 16.95 48 222558 68691 110298002
Wrong technique in product usage process 39.57 16.95 72 222534 87276 110279417
Rhinalgia 39.43 16.95 44 222562 3885 110362808
Blood pressure fluctuation 39.23 16.95 56 222550 74768 110291925
Immature granulocyte percentage increased 39.18 16.95 12 222594 73 110366620
General physical health deterioration 39.15 16.95 611 221995 424684 109942009
Autism spectrum disorder 39.10 16.95 32 222574 1916 110364777
Self-injurious ideation 39.10 16.95 46 222560 4300 110362393
C-reactive protein 38.90 16.95 7 222599 30324 110336369
Eosinophilic colitis 38.81 16.95 21 222585 622 110366071
Skin disorder 38.62 16.95 19 222587 42894 110323799
Impulsive behaviour 38.31 16.95 40 222566 3275 110363418
Suicidal behaviour 38.29 16.95 41 222565 3456 110363237
Intestinal ischaemia 38.22 16.95 94 222512 16085 110350608
Testicular atrophy 38.06 16.95 18 222588 398 110366295
Tension 38.02 16.95 49 222557 5029 110361664
Spleen congestion 37.87 16.95 19 222587 480 110366213
Victim of chemical submission 37.76 16.95 23 222583 856 110365837
Psychomotor retardation 37.54 16.95 61 222545 7731 110358962
Stupor 37.53 16.95 63 222543 8202 110358491
Tooth disorder 37.44 16.95 7 222599 29502 110337191
Hyperbilirubinaemia 37.40 16.95 8 222598 30663 110336030
Gastrointestinal obstruction 37.20 16.95 33 222573 2207 110364486
Drug-disease interaction 37.19 16.95 31 222575 1905 110364788
Type 2 diabetes mellitus 37.13 16.95 207 222399 177025 110189668
Transfusion 37.07 16.95 4 222602 25468 110341225
Cardiac arrest 37.01 16.95 579 222027 196174 110170519
Lower limb fracture 36.98 16.95 59 222547 75289 110291404
Electroconvulsive therapy 36.91 16.95 12 222594 91 110366602
Cervix neoplasm 36.57 16.95 14 222592 179 110366514
Sinus rhythm 36.57 16.95 24 222582 1019 110365674
Hallucinations, mixed 36.50 16.95 64 222542 8629 110358064
Eye disorder 36.37 16.95 7 222599 28899 110337794
Walking aid user 36.34 16.95 4 222602 25071 110341622
Impaired quality of life 36.25 16.95 8 222598 30009 110336684
Stress 36.17 16.95 101 222505 105247 110261446
Alcohol abuse 36.03 16.95 47 222559 4882 110361811
Left atrial enlargement 35.94 16.95 29 222577 1702 110364991
Dysuria 35.80 16.95 41 222565 60190 110306503
Cerebral infarction 35.73 16.95 31 222575 51807 110314886
Injection site mass 35.48 16.95 4 222602 24609 110342084
Hypersplenism 35.39 16.95 21 222585 745 110365948
Drug level fluctuating 35.32 16.95 23 222583 964 110365729
Neglect of personal appearance 35.10 16.95 17 222589 397 110366296
Rash macular 35.01 16.95 17 222589 38669 110328024
Total cholesterol/HDL ratio increased 34.87 16.95 17 222589 403 110366290
Blood disorder 34.61 16.95 67 222539 9743 110356950
Cognitive disorder 34.33 16.95 297 222309 87214 110279479
Abdominal pain lower 34.33 16.95 16 222590 37267 110329426
Hepatic cirrhosis 34.10 16.95 52 222554 67574 110299119
Lymphocytosis 34.09 16.95 48 222558 5363 110361330
Seminoma 34.08 16.95 15 222591 279 110366414
Flat affect 34.04 16.95 33 222573 2472 110364221
Catecholamines urine increased 33.99 16.95 9 222597 29 110366664
Manic symptom 33.98 16.95 15 222591 281 110366412
Drug level changed 33.98 16.95 19 222587 601 110366092
Vascular encephalopathy 33.97 16.95 21 222585 803 110365890
Limb discomfort 33.97 16.95 20 222586 40834 110325859
Blood creatine phosphokinase decreased 33.92 16.95 25 222581 1282 110365411
Dementia with Lewy bodies 33.70 16.95 23 222583 1043 110365650
Osteopenia 33.60 16.95 3 222603 22206 110344487
Electrocardiogram ST-T change 33.48 16.95 27 222579 1583 110365110
Ventricular fibrillation 33.27 16.95 21 222585 41292 110325401
Stoma site reaction 33.26 16.95 17 222589 447 110366246
Disseminated intravascular coagulation 33.23 16.95 21 222585 41265 110325428
Ischaemic stroke 33.19 16.95 21 222585 41242 110325451
Localised infection 33.15 16.95 23 222583 43025 110323668
Acne 33.07 16.95 13 222593 33507 110333186
Large intestinal obstruction 32.92 16.95 40 222566 3868 110362825
Ideas of reference 32.83 16.95 13 222593 183 110366510
Disability 32.79 16.95 10 222596 30213 110336480
Product storage error 32.70 16.95 3 222603 21725 110344968
Product administration error 32.63 16.95 155 222451 37062 110329631
Malaise 32.62 16.95 1659 220947 670160 109696533
Galactorrhoea 32.54 16.95 41 222565 4114 110362579
Angiodermatitis 32.51 16.95 13 222593 188 110366505
Incontinence 32.48 16.95 90 222516 16545 110350148
Non-high-density lipoprotein cholesterol increased 32.33 16.95 16 222590 392 110366301
Eye swelling 32.31 16.95 13 222593 33035 110333658
Blood folate decreased 32.18 16.95 31 222575 2304 110364389
Insurance issue 32.11 16.95 68 222538 10544 110356149
Vasculitis 32.10 16.95 16 222590 35857 110330836
Drug tolerance decreased 31.95 16.95 8 222598 27532 110339161
Blood lactate dehydrogenase decreased 31.86 16.95 16 222590 405 110366288
Central obesity 31.85 16.95 29 222577 2007 110364686
Wrong product administered 31.75 16.95 69 222537 10891 110355802
Therapy non-responder 31.73 16.95 186 222420 157121 110209572
Glaucoma 31.62 16.95 4 222602 22513 110344180
Incorrect route of product administration 31.59 16.95 50 222556 64011 110302682
Dilatation ventricular 31.58 16.95 40 222566 4035 110362658
Electrocardiogram T wave amplitude decreased 31.52 16.95 20 222586 801 110365892
Cholestasis 31.21 16.95 51 222555 64467 110302226
Musculoskeletal discomfort 31.14 16.95 5 222601 23533 110343160
Physical assault 31.13 16.95 26 222580 1602 110365091
Hyperthermia 31.12 16.95 104 222502 21168 110345525
Unevaluable event 31.02 16.95 215 222391 59012 110307681
Hypercalcaemia 30.85 16.95 29 222577 46628 110320065
Prescribed overdose 30.79 16.95 83 222523 87498 110279195
Self-destructive behaviour 30.78 16.95 20 222586 835 110365858
Encephalitis toxic 30.70 16.95 14 222592 284 110366409
Mean cell haemoglobin concentration 30.69 16.95 9 222597 46 110366647
Deep vein thrombosis 30.61 16.95 161 222445 139726 110226967
Stoma site irritation 30.60 16.95 15 222591 360 110366333
Borderline personality disorder 30.52 16.95 22 222584 1090 110365603
Echolalia 30.51 16.95 17 222589 534 110366159
Oxygen saturation decreased 30.40 16.95 188 222418 156794 110209899
Intervertebral disc protrusion 30.35 16.95 9 222597 27689 110339004
Tobacco user 29.99 16.95 19 222587 759 110365934
Serositis 29.88 16.95 25 222581 1544 110365149
Spasmodic dysphonia 29.84 16.95 17 222589 558 110366135
Medication error 29.80 16.95 334 222272 105032 110261661
Hemiplegia 29.78 16.95 5 222601 22777 110343916
Gastric ulcer 29.73 16.95 22 222584 39805 110326888
Grandiosity 29.73 16.95 17 222589 562 110366131
Bladder trabeculation 29.66 16.95 10 222596 86 110366607
Disturbance in attention 29.55 16.95 220 222386 61775 110304918
Red cell distribution width decreased 29.48 16.95 29 222577 2212 110364481
Glomerular filtration rate decreased 29.43 16.95 126 222480 28830 110337863
Neurotoxicity 29.39 16.95 25 222581 42182 110324511
Movement disorder 29.33 16.95 148 222458 36256 110330437
Retrograde ejaculation 29.29 16.95 15 222591 396 110366297
Bone disorder 29.19 16.95 4 222602 21188 110345505
Prostate cancer 29.14 16.95 20 222586 37621 110329072
Hypersexuality 29.11 16.95 27 222579 1913 110364780
Photophobia 28.92 16.95 8 222598 25763 110340930
Patient restraint 28.87 16.95 10 222596 94 110366599
Thought blocking 28.86 16.95 13 222593 256 110366437
Oral pain 28.84 16.95 20 222586 37424 110329269
Drug titration error 28.83 16.95 25 222581 1622 110365071
Defect conduction intraventricular 28.77 16.95 18 222588 703 110365990
Bone marrow failure 28.67 16.95 45 222561 57803 110308890
Neoplasm progression 28.59 16.95 54 222552 64541 110302152
Jaundice 28.49 16.95 47 222559 59189 110307504
Urticaria cholinergic 28.43 16.95 9 222597 62 110366631
Impaired work ability 28.20 16.95 9 222597 26410 110340283
Cardiac death 28.19 16.95 25 222581 1671 110365022
Testicular germ cell cancer metastatic 28.18 16.95 9 222597 64 110366629
Drug resistance 27.98 16.95 202 222404 56172 110310521
Wrong drug 27.98 16.95 15 222591 436 110366257
Microcytosis 27.89 16.95 15 222591 439 110366254
Blood pressure diastolic decreased 27.87 16.95 19 222587 35866 110330827
Upper gastrointestinal haemorrhage 27.77 16.95 36 222570 50060 110316633
Cardiac steatosis 27.71 16.95 9 222597 68 110366625
Left atrial dilatation 27.68 16.95 35 222571 3525 110363168
Polyneuropathy 27.58 16.95 15 222591 31997 110334696
Coagulopathy 27.56 16.95 25 222581 40886 110325807
Lymphocyte percentage decreased 27.55 16.95 43 222563 5267 110361426
Hepatic function abnormal 27.51 16.95 90 222516 89205 110277488
Proteinuria 27.50 16.95 24 222582 39994 110326699
Drug withdrawal syndrome 27.42 16.95 150 222456 37904 110328789
Flatulence 27.37 16.95 39 222567 52110 110314583
Heart rate increased 27.32 16.95 424 222182 143410 110223283
Bacteraemia 27.27 16.95 27 222579 42363 110324330
Hepatic steatosis 27.21 16.95 180 222426 48651 110318042
Musculoskeletal chest pain 27.15 16.95 12 222594 28835 110337858
Drug monitoring procedure not performed 27.02 16.95 22 222584 1308 110365385
Anticholinergic syndrome 27.01 16.95 38 222568 4242 110362451
Premature delivery 26.91 16.95 14 222592 30618 110336075
Hypoacusis 26.84 16.95 19 222587 35172 110331521
Photosensitivity reaction 26.81 16.95 9 222597 25580 110341113
Visceral congestion 26.80 16.95 22 222584 1323 110365370
Myoclonic epilepsy 26.77 16.95 30 222576 2661 110364032
Device malfunction 26.76 16.95 9 222597 25549 110341144
Chronic hepatitis C 26.72 16.95 17 222589 684 110366009
Spinal pain 26.71 16.95 3 222603 18512 110348181
Blood bilirubin increased 26.70 16.95 72 222534 75900 110290793
Joint dislocation 26.69 16.95 18 222588 34172 110332521
Rehabilitation therapy 26.65 16.95 27 222579 2134 110364559
Purpura 26.58 16.95 8 222598 24380 110342313
Weight fluctuation 26.55 16.95 6 222600 22139 110344554
Poverty of speech 26.53 16.95 16 222590 585 110366108
Aplastic anaemia 26.45 16.95 8 222598 24300 110342393
Pulmonary hypertension 26.39 16.95 44 222562 55176 110311517
Staphylococcal infection 26.35 16.95 64 222542 69880 110296813
Myelodysplastic syndrome 26.34 16.95 22 222584 37462 110329231
Delusion of reference 26.34 16.95 12 222594 243 110366450
Flank pain 26.30 16.95 7 222599 23123 110343570
Parkinson's disease 26.21 16.95 23 222583 1516 110365177
Poor personal hygiene 26.09 16.95 16 222590 603 110366090
Asterixis 26.08 16.95 32 222574 3126 110363567
Somatic symptom disorder 26.07 16.95 32 222574 3127 110363566
Non-Hodgkin's lymphoma unspecified histology aggressive 26.05 16.95 5 222601 0 110366693
Lymphocyte count 25.93 16.95 8 222598 50 110366643
Coronary artery disease 25.91 16.95 67 222539 71623 110295070
Blood loss anaemia 25.81 16.95 3 222603 18022 110348671
Chest pain 25.79 16.95 569 222037 375806 109990887
Aortic dilatation 25.77 16.95 27 222579 2219 110364474
Left ventricular dilatation 25.73 16.95 22 222584 1400 110365293
Sputum discoloured 25.72 16.95 12 222594 27933 110338760
Femur fracture 25.65 16.95 31 222575 44438 110322255
Musculoskeletal disorder 25.50 16.95 7 222599 22657 110344036
White blood cell disorder 25.46 16.95 35 222571 3824 110362869
Brain injury 25.42 16.95 72 222534 13404 110353289
Electrocardiogram ST segment abnormal 25.17 16.95 24 222582 1761 110364932
Tenderness 25.06 16.95 14 222592 29423 110337270
Electrocardiogram repolarisation abnormality 24.90 16.95 27 222579 2308 110364385
Mean cell haemoglobin 24.89 16.95 9 222597 97 110366596
Tangentiality 24.73 16.95 11 222595 210 110366483
Oligospermia 24.69 16.95 7 222599 31 110366662
Blood urine present 24.59 16.95 9 222597 24236 110342457
Transient ischaemic attack 24.53 16.95 58 222548 63924 110302769
Respiratory tract congestion 24.42 16.95 16 222590 30841 110335852
Electrocardiogram QT shortened 24.40 16.95 12 222594 290 110366403
Red blood cell nucleated morphology present 24.34 16.95 7 222599 33 110366660
Sudden cardiac death 24.32 16.95 42 222564 5595 110361098
Water intoxication 24.12 16.95 18 222588 941 110365752
Creatinine renal clearance decreased 24.06 16.95 7 222599 21808 110344885
Antisocial personality disorder 24.02 16.95 8 222598 66 110366627
Substance abuse 23.91 16.95 67 222539 12396 110354297
Dermatitis allergic 23.91 16.95 7 222599 21717 110344976
Osteomyelitis 23.90 16.95 23 222583 36577 110330116
Blood sodium decreased 23.67 16.95 145 222461 38174 110328519
Speech disorder 23.65 16.95 208 222398 61361 110305332
Full blood count decreased 23.61 16.95 18 222588 32081 110334612
Parkinsonism hyperpyrexia syndrome 23.59 16.95 15 222591 603 110366090
Rib fracture 23.51 16.95 20 222586 33750 110332943
Necrotising colitis 23.51 16.95 23 222583 1742 110364951
Diet refusal 23.50 16.95 17 222589 847 110365846
End stage renal disease 23.48 16.95 7 222599 21466 110345227
Myositis 23.47 16.95 17 222589 31099 110335594
Enterococcal infection 23.47 16.95 6 222600 20360 110346333
Rhinitis allergic 23.28 16.95 4 222602 17918 110348775
High-grade B-cell lymphoma 23.23 16.95 11 222595 244 110366449
Red blood cell elliptocytes present 23.23 16.95 10 222596 176 110366517
Hallucination, tactile 23.21 16.95 18 222588 997 110365696
Lymphocyte morphology abnormal 23.21 16.95 18 222588 997 110365696
Excessive masturbation 23.17 16.95 9 222597 120 110366573
Abnormal clotting factor 23.12 16.95 10 222596 178 110366515
Face oedema 23.09 16.95 20 222586 33449 110333244
Hyponatraemia 23.06 16.95 304 222302 217349 110149344
Abortion spontaneous 23.03 16.95 21 222585 34261 110332432
Soliloquy 23.02 16.95 18 222588 1009 110365684
Skin reaction 22.93 16.95 7 222599 21137 110345556
Gastric disorder 22.93 16.95 20 222586 33337 110333356
Orthostatic hypertension 22.90 16.95 18 222588 1017 110365676
Infusion site reaction 22.85 16.95 4 222602 17678 110349015
Colitis 22.82 16.95 117 222489 102206 110264487
Product dispensing issue 22.81 16.95 15 222591 639 110366054
Chronic sinusitis 22.73 16.95 11 222595 25073 110341620
Transferrin saturation decreased 22.73 16.95 20 222586 1323 110365370
Oropharyngeal pain 22.71 16.95 169 222437 135107 110231586
Cyclothymic disorder 22.67 16.95 11 222595 258 110366435
Pseudomonas infection 22.65 16.95 14 222592 27839 110338854
Right ventricular failure 22.60 16.95 12 222594 25942 110340751
Drowning 22.59 16.95 17 222589 900 110365793
Gingival bleeding 22.56 16.95 6 222600 19833 110346860
Electrocardiogram ST-T segment abnormal 22.51 16.95 17 222589 905 110365788
Presyncope 22.40 16.95 40 222566 48847 110317846
Infusion site pain 22.38 16.95 4 222602 17415 110349278
Pemphigoid 22.34 16.95 6 222600 19701 110346992
Gastrointestinal sounds abnormal 22.34 16.95 42 222564 5976 110360717
Deafness 22.31 16.95 13 222593 26696 110339997
Autonomic nervous system imbalance 22.28 16.95 41 222565 5739 110360954
Stoma site discomfort 22.27 16.95 9 222597 134 110366559
Chromaturia 22.20 16.95 16 222590 29344 110337349
Globulin abnormal 22.12 16.95 5 222601 6 110366687
Troponin abnormal 22.09 16.95 9 222597 137 110366556
Crying 22.09 16.95 12 222594 25616 110341077
Blood bicarbonate increased 21.96 16.95 20 222586 1384 110365309
Testicular cancer metastatic 21.90 16.95 8 222598 89 110366604
Endocarditis enterococcal 21.89 16.95 12 222594 365 110366328
Eosinophil percentage increased 21.80 16.95 21 222585 1561 110365132
Skin necrosis 21.79 16.95 8 222598 21504 110345189
Pericarditis 21.79 16.95 310 222296 218804 110147889
Trifascicular block 21.75 16.95 10 222596 207 110366486
Sensory loss 21.70 16.95 8 222598 21449 110345244
Bacterial infection 21.70 16.95 37 222569 45999 110320694
Muscle mass 21.68 16.95 13 222593 470 110366223
Intestinal infarction 21.65 16.95 20 222586 1410 110365283
Postoperative wound infection 21.64 16.95 3 222603 15750 110350943
Liver function test abnormal 21.56 16.95 223 222383 68727 110297966
Loss of libido 21.55 16.95 29 222577 3104 110363589
Drop attacks 21.54 16.95 18 222588 1110 110365583
Carditis 21.49 16.95 10 222596 213 110366480
Posturing 21.48 16.95 18 222588 1114 110365579
Nightmare 21.47 16.95 28 222578 38835 110327858
Eye movement disorder 21.39 16.95 55 222551 9673 110357020
Spinal osteoarthritis 21.32 16.95 7 222599 20176 110346517
Gait disturbance 21.30 16.95 413 222193 277795 110088898
Testis cancer 21.22 16.95 19 222587 1286 110365407
Abulia 21.12 16.95 19 222587 1294 110365399
Alcohol problem 21.10 16.95 7 222599 57 110366636
Schizoaffective disorder depressive type 21.09 16.95 6 222600 27 110366666
Drug level above therapeutic 20.97 16.95 61 222545 11527 110355166
Myocardial necrosis marker increased 20.94 16.95 32 222574 3848 110362845
Faecalith 20.91 16.95 6 222600 28 110366665
Slow speech 20.86 16.95 30 222576 3418 110363275
Haemodialysis 20.85 16.95 5 222601 17714 110348979
Blood folate abnormal 20.84 16.95 4 222602 0 110366693
Gender dysphoria 20.78 16.95 7 222599 60 110366633
Epstein-Barr virus infection 20.69 16.95 6 222600 18732 110347961
Hyperosmolar state 20.60 16.95 15 222591 755 110365938
Influenza B virus test positive 20.57 16.95 12 222594 412 110366281
Dermatitis bullous 20.52 16.95 5 222601 17524 110349169
Portal tract inflammation 20.51 16.95 10 222596 237 110366456
Epilepsy 20.42 16.95 299 222307 99910 110266783
Febrile bone marrow aplasia 20.41 16.95 5 222601 17460 110349233
Miosis 20.33 16.95 93 222513 21890 110344803
Resting tremor 20.29 16.95 21 222585 1702 110364991
Eyelid function disorder 20.28 16.95 13 222593 530 110366163
Product dose omission issue 20.24 16.95 816 221790 320966 110045727
Ecchymosis 20.19 16.95 5 222601 17333 110349360
Electrocardiogram change 20.18 16.95 19 222587 1372 110365321
Myasthenia gravis 20.16 16.95 9 222597 21502 110345191
Lymphoedema 20.14 16.95 3 222603 14926 110351767
Conjunctivitis 20.09 16.95 23 222583 33769 110332924
Ventricular hypertrophy 20.00 16.95 44 222562 7001 110359692
Petechiae 19.98 16.95 11 222595 23306 110343387
Life support 19.94 16.95 12 222594 437 110366256
Alcohol detoxification 19.83 16.95 7 222599 70 110366623
Feeling jittery 19.77 16.95 3 222603 14719 110351974
Aspartate aminotransferase decreased 19.76 16.95 19 222587 1409 110365284
Blood urea nitrogen/creatinine ratio decreased 19.70 16.95 10 222596 259 110366434
Illness anxiety disorder 19.67 16.95 10 222596 260 110366433
Haematotoxicity 19.48 16.95 9 222597 21073 110345620
Pulmonary mass 19.47 16.95 28 222578 37273 110329420
Drug dependence 19.45 16.95 45 222561 49975 110316718
Hyperuricaemia 19.42 16.95 3 222603 14528 110352165
Antidepressant therapy 19.40 16.95 5 222601 14 110366679
Subdural haematoma 19.39 16.95 27 222579 36427 110330266
Head discomfort 19.36 16.95 7 222599 18993 110347700
Hypochromasia 19.34 16.95 14 222592 698 110365995
Illusion 19.33 16.95 22 222584 1985 110364708
Adjusted calcium increased 19.31 16.95 7 222599 76 110366617
Diarrhoea haemorrhagic 19.23 16.95 4 222602 15635 110351058
Obsessive-compulsive personality disorder 19.22 16.95 8 222598 129 110366564
Ankylosing spondylitis 19.18 16.95 4 222602 15608 110351085
Needle issue 19.18 16.95 6 222600 17834 110348859
Hypoalbuminaemia 19.17 16.95 18 222588 28956 110337737
Eosinophil percentage decreased 19.14 16.95 11 222595 367 110366326
Learning disability 19.07 16.95 9 222597 198 110366495
Peripheral sensory neuropathy 19.06 16.95 5 222601 16675 110350018
Breath sounds abnormal 19.00 16.95 14 222592 25390 110341303
Grimacing 18.97 16.95 15 222591 855 110365838
Viral myocarditis 18.96 16.95 14 222592 720 110365973
Stoma site extravasation 18.93 16.95 11 222595 375 110366318
Disorganised speech 18.91 16.95 28 222578 3275 110363418
Organising pneumonia 18.90 16.95 3 222603 14240 110352453
Bundle branch block left 18.84 16.95 63 222543 12825 110353868
Electrocardiogram PR shortened 18.82 16.95 11 222595 379 110366314
Monocytopenia 18.79 16.95 9 222597 205 110366488
Dermatitis 18.76 16.95 17 222589 27820 110338873
Staring 18.73 16.95 26 222580 2866 110363827
Pulmonary haemorrhage 18.67 16.95 5 222601 16451 110350242
Pharyngeal oedema 18.62 16.95 5 222601 16423 110350270
Norepinephrine increased 18.61 16.95 7 222599 85 110366608
Mitral valve replacement 18.60 16.95 13 222593 613 110366080
Olfactory nerve disorder 18.51 16.95 6 222600 45 110366648
Paraneoplastic rash 18.39 16.95 7 222599 88 110366605
Temperature intolerance 18.37 16.95 3 222603 13947 110352746
Delusional perception 18.34 16.95 11 222595 398 110366295
Cardiac septal hypertrophy 18.34 16.95 11 222595 398 110366295
Irregular breathing 18.32 16.95 13 222593 628 110366065
Blood test abnormal 18.24 16.95 109 222497 28445 110338248
Compensatory sweating 18.17 16.95 6 222600 48 110366645
Transaminases increased 18.10 16.95 66 222540 63324 110303369
Compulsions 18.07 16.95 11 222595 409 110366284
Glucose tolerance impaired 18.01 16.95 52 222554 9785 110356908
Pneumoconiosis 18.01 16.95 10 222596 312 110366381
Platelet aggregation abnormal 17.86 16.95 6 222600 51 110366642
Somatic dysfunction 17.86 16.95 6 222600 51 110366642
Renal tubular necrosis 17.84 16.95 21 222585 30454 110336239
Sexually inappropriate behaviour 17.79 16.95 13 222593 658 110366035
Dropped head syndrome 17.75 16.95 12 222594 536 110366157
Granulocytosis 17.74 16.95 11 222595 423 110366270
Consciousness fluctuating 17.73 16.95 22 222584 2174 110364519
Enterocolitis 17.65 16.95 8 222598 18941 110347752
Immunodeficiency 17.60 16.95 32 222574 38806 110327887
Social anxiety disorder 17.59 16.95 15 222591 951 110365742
Protein total increased 17.57 16.95 33 222573 4691 110362002
Immune system disorder 17.57 16.95 3 222603 13498 110353195
Mouth haemorrhage 17.54 16.95 3 222603 13485 110353208
Amylase decreased 17.49 16.95 9 222597 240 110366453
Acute myocardial infarction 17.46 16.95 98 222508 83679 110283014
Abdominal tenderness 17.43 16.95 60 222546 12397 110354296
Ataxia 17.39 16.95 112 222494 29996 110336697
Skin cancer 17.38 16.95 7 222599 17777 110348916
Gastritis 17.33 16.95 53 222553 53646 110313047
Blood creatine decreased 17.31 16.95 10 222596 337 110366356
Eyelid ptosis 17.26 16.95 3 222603 13324 110353369
Respiratory syncytial virus infection 17.21 16.95 4 222602 14480 110352213
Empyema 17.21 16.95 36 222570 5534 110361159
C-reactive protein decreased 17.14 16.95 25 222581 2884 110363809
Nephropathy toxic 17.11 16.95 18 222588 27460 110339233
Vitamin B complex deficiency 17.10 16.95 15 222591 988 110365705
Proctalgia 17.07 16.95 3 222603 13219 110353474
Metastatic neoplasm 17.04 16.95 37 222569 5836 110360857
Nasal polyps 17.03 16.95 3 222603 13197 110353496
Hepatitis cholestatic 17.02 16.95 7 222599 17559 110349134
Tooth fracture 16.97 16.95 3 222603 13164 110353529

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dystonia 25.32 24.66 7 224 28 113694
Parkinsonism 25.32 24.66 7 224 28 113694

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014150 Antipsychotic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37887 adrenergic antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:65191 second generation antipsychotic
CHEBI has role CHEBI:65259 GABA antagonist
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N05AH Diazepines, oxazepines, thiazepines and oxepines 6 drugs
asenapineclotiapineloxapineolanzapinequetiapinesamidorphan

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
Histone H1.0 Nuclear other Ki 9 CHEMBL
Calmodulin-1 Cytosolic other IC50 4.70 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Transporter Transporter Ki 6.41 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 5A GPCR ANTAGONIST Ki 5.30 IUPHAR
Calmodulin Cytosolic other Kd 4.21 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 8.45 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL

External reference:

IDSource
4019488 VUID
N0000147608 NUI
D00283 KEGG_DRUG
216102 RXNORM
C0009079 UMLSCUI
CHEBI:3766 CHEBI
VBU PDB_CHEM_ID
CHEMBL42 ChEMBL_ID
DB00363 DRUGBANK_ID
D003024 MESH_DESCRIPTOR_UI
135398737 PUBCHEM_CID
38 IUPHAR_LIGAND_ID
2612 INN_ID
J60AR2IKIC UNII
11496 MMSL
420 MMSL
4484 MMSL
50904 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
96221003 SNOMEDCT_US
4019488 VANDF
4024939 VANDF
4036908 VANDF
4037056 VANDF
4037345 VANDF
4040180 VANDF
J60AR2IKIC INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0825 TABLET 25 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0860 TABLET 100 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0972 TABLET 50 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0973 TABLET 200 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3813 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3813 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3815 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3815 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3816 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3816 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3817 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3817 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 27 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7087 TABLET 100 mg ORAL ANDA 28 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7088 TABLET 200 mg ORAL ANDA 28 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7089 TABLET 25 mg ORAL ANDA 28 sections
CLOZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7406 TABLET 50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-141 TABLET 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-141 TABLET 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-142 TABLET 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-142 TABLET 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 48433-022 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 48433-023 TABLET 25 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 48433-024 TABLET 100 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 48433-025 TABLET 200 mg ORAL ANDA 29 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 51079-288 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections