DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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Download
L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
proxyphylline 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
N-methylated xanthine derivatives
2323
603-00-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
proxyphylline
hydroxypropyltheophylline
monophylline
oxypropyltheophylline
proxiphylline
purophyllin
beta-Hydroxypropyltheophylline
Molecular weight: 238.25
Formula: C10H14N4O3
CLOGP: -0.56
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 78.67
ALOGS: -1.21
ROTB: 2
Drug dosage:
Dose
Unit
Route
1.20
g
O
1.20
g
P
1.20
g
R
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
99 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
7.80 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
1.17 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.59 L/kg
Lombardo F, Berellini G, Obach RS
Showing 1 to 4 of 4 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
R03DA03
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC
R03DB03
RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines and adrenergics
MeSH PA
D018927
Anti-Asthmatic Agents
MeSH PA
D001993
Bronchodilator Agents
MeSH PA
D018373
Peripheral Nervous System Agents
MeSH PA
D019141
Respiratory System Agents
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
1.66
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
006056
NDDF
13G1DMN4P0
UNII
34906
RXNORM
4977
PUBCHEM_CID
969
INN_ID
C003237
MESH_SUPPLEMENTAL_RECORD_UI
C0072511
UMLSCUI
CHEBI:32070
CHEBI
CHEMBL290644
ChEMBL_ID
CHEMBL37019
ChEMBL_ID
Showing 1 to 10 of 13 entries
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Pharmaceutical products:
None
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proxyphylline