acefylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 49 652-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epicophylline
  • acefylline piperazine
  • acefylline piperazine salt
  • acepifylline
  • aethaphyllinum
  • piperazine theophylline ethanoate
  • acephylline
  • acefylline
  • carboxymethyltheophylline
  • theophyllineacetic acid
Acefylline is a bronchodilator agent, relaxing brochial smooth muscle and opposing the effects of many broncho-constrictor mediators. Also, it relaxes smooth muscle in the urinary and biliary ways.
  • Molecular weight: 238.20
  • Formula: C9H10N4O4
  • CLOGP: -0.66
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 95.74
  • ALOGS: -1.21
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DA09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchitis indication 32398004 DOID:6132
Disorder of cardiovascular system indication 49601007 DOID:1287
Asthma indication 195967001 DOID:2841




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.76 acidic
pKa2 1.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adenosine receptor A2b GPCR Ki 4.56 CHEMBL

External reference:

IDSource
C0050405 UMLSCUI
CHEBI:94615 CHEBI
CHEMBL70246 ChEMBL_ID
D07062 KEGG_DRUG
CHEMBL2106660 ChEMBL_ID
DB13573 DRUGBANK_ID
C019140 MESH_SUPPLEMENTAL_RECORD_UI
M494UE2YEP UNII
69550 PUBCHEM_CID
005935 NDDF
005936 NDDF
1583 INN_ID
18833-13-1 SECONDARY_CAS_RN

Pharmaceutical products:

None