doxofylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| N-methylated xanthine derivatives | 959 | 69975-86-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.80 | g | O |
| 0.80 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.03 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 6.83 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.66 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia | 63.56 | 41.51 | 44 | 381 | 362583 | 34593923 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pneumonia | 84.46 | 45.09 | 54 | 517 | 660192 | 79083625 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03DA11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D010726 | Phosphodiesterase Inhibitors |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:35523 | bronchodilator |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:51177 | anti-tussive |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.36 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D03898 | KEGG_DRUG |
| C0058721 | UMLSCUI |
| CHEBI:94714 | CHEBI |
| 7UH | PDB_CHEM_ID |
| CHEMBL1527608 | ChEMBL_ID |
| DB09273 | DRUGBANK_ID |
| C029797 | MESH_SUPPLEMENTAL_RECORD_UI |
| 50942 | PUBCHEM_CID |
| 5156 | INN_ID |
| MPM23GMO7Z | UNII |
| 010905 | NDDF |
| 1173992002 | SNOMEDCT_US |
| 1177091008 | SNOMEDCT_US |
Pharmaceutical products:
None