theophylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
N-methylated xanthine derivatives	2620	58-55-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: aminophyllin aminophylline theophylline 1,3-Dimethylxanthine armophylline cetraphylline chronophyllin duraphyllin elixophyllin elixophylline etheophyl lanophyllin pseudotheophylline theophyllin throphylline xanthium theophylline anhydrous aminophylline dihydrate theophylline sodium glycinate theophylline monohydrate	A plant genus of the family ASTERACEAE. The name "prickly burweed" is sometimes used but causes confusion with AMSINCKIA. Molecular weight: 180.17 Formula: C7H8N4O2 CLOGP: -0.03 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 69.30 ALOGS: -0.80 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aminophyllin
aminophylline
theophylline
1,3-Dimethylxanthine
armophylline
cetraphylline
chronophyllin
duraphyllin
elixophyllin
elixophylline
etheophyl
lanophyllin
pseudotheophylline
theophyllin
throphylline
xanthium
theophylline anhydrous
aminophylline dihydrate
theophylline sodium glycinate
theophylline monohydrate

A plant genus of the family ASTERACEAE. The name "prickly burweed" is sometimes used but causes confusion with AMSINCKIA.

Molecular weight: 180.17
Formula: C7H8N4O2
CLOGP: -0.03
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 69.30
ALOGS: -0.80
ROTB: 0

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	O
0.40	g	P
0.40	g	R
0.60	g	O
0.60	g	P
0.60	g	R

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	8.30 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	18 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	48.12 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.51 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.86 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.61 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	7.20 hours	Lombardo F, Berellini G, Obach RS
BA (Bioavailability)	1 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

Date	Agency	Company	Orphan
April 19, 1940	FDA	GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	662.75	13.78	496	26311	127065	63335150
Wheezing	528.16	13.78	386	26421	95209	63367006
Dyspnoea	231.56	13.78	706	26101	660607	62801608
Productive cough	206.19	13.78	188	26619	63020	63399195
Chronic obstructive pulmonary disease	176.77	13.78	172	26635	62514	63399701
Sputum discoloured	161.14	13.78	95	26712	16252	63445963
Rales	149.87	13.78	83	26724	12614	63449601
Cough	136.77	13.78	348	26459	292395	63169820
Forced expiratory volume decreased	123.55	13.78	54	26753	4914	63457301
Breath sounds abnormal	119.38	13.78	68	26739	10905	63451310
Chest discomfort	117.53	13.78	185	26622	109784	63352431
Sinus tachycardia	115.92	13.78	90	26717	24178	63438037
Bronchial neoplasm	113.98	13.78	29	26778	471	63461744
Nasal oedema	113.63	13.78	37	26770	1485	63460730
Pulmonary pain	110.36	13.78	45	26762	3445	63458770
Bronchial haemorrhage	109.12	13.78	29	26778	563	63461652
Nasal turbinate hypertrophy	106.36	13.78	30	26777	733	63461482
Nasal congestion	103.48	13.78	133	26674	65527	63396688
Endometrial ablation	95.14	13.78	29	26778	935	63461280
Obstructive airways disorder	95.04	13.78	75	26732	20624	63441591
Sleep disorder due to a general medical condition	95.04	13.78	61	26746	12127	63450088
Prolonged expiration	91.48	13.78	29	26778	1067	63461148
Bronchial disorder	90.82	13.78	30	26777	1260	63460955
Heart sounds	89.99	13.78	28	26779	968	63461247
Alopecia	89.67	13.78	17	26790	337519	63124696
Pneumonia	88.44	13.78	404	26403	456363	63005852
Rhonchi	84.15	13.78	34	26773	2542	63459673
Hypercapnia	79.55	13.78	41	26766	5390	63456825
Systemic lupus erythematosus	75.20	13.78	3	26804	208915	63253300
Respiratory tract infection	73.29	13.78	89	26718	41394	63420821
Bronchitis chronic	64.16	13.78	33	26774	4320	63457895
Status asthmaticus	63.55	13.78	21	26786	883	63461332
Lower respiratory tract infection	61.29	13.78	157	26650	132150	63330065
Occupational asthma	60.75	13.78	14	26793	146	63462069
Treatment failure	59.76	13.78	7	26800	199036	63263179
Dyspnoea exertional	59.65	13.78	98	26709	60204	63402011
Rheumatoid arthritis	59.02	13.78	17	26790	253802	63208413
Depressive symptom	57.31	13.78	30	26777	4072	63458143
Respiration abnormal	57.28	13.78	35	26772	6382	63455833
Joint swelling	56.84	13.78	34	26773	327632	63134583
Bronchial obstruction	56.59	13.78	22	26785	1485	63460730
Neurosensory hypoacusis	55.69	13.78	14	26793	216	63461999
Contraindicated product administered	53.59	13.78	13	26794	217635	63244580
Granuloma	52.91	13.78	32	26775	5729	63456486
Toxicity to various agents	52.45	13.78	225	26582	247025	63215190
Middle insomnia	52.08	13.78	43	26764	12600	63449615
Depressed mood	52.01	13.78	74	26733	40117	63422098
Hepatic enzyme increased	51.99	13.78	11	26796	202317	63259898
Rhinitis	51.78	13.78	41	26766	11325	63450890
Amyloid arthropathy	51.12	13.78	16	26791	564	63461651
Eosinophil count increased	51.03	13.78	40	26767	10888	63451327
Fatigue	49.83	13.78	200	26607	887828	62574387
Infusion related reaction	49.26	13.78	21	26786	245500	63216715
Oesophageal dilatation	47.98	13.78	14	26793	387	63461828
Bronchospasm	47.88	13.78	47	26760	17233	63444982
Drug intolerance	46.90	13.78	37	26770	308624	63153591
Rhinorrhoea	46.24	13.78	92	26715	65485	63396730
Chest pain	46.15	13.78	197	26610	215762	63246453
Affective disorder	46.04	13.78	30	26777	6116	63456099
Eosinophilic granulomatosis with polyangiitis	45.49	13.78	21	26786	2171	63460044
Drug interaction	45.15	13.78	204	26603	228927	63233288
Exercise tolerance decreased	44.06	13.78	28	26779	5469	63456746
Multiple drug therapy	43.47	13.78	24	26783	3622	63458593
Respiratory disorder	43.43	13.78	67	26740	39015	63423200
Swelling	43.12	13.78	32	26775	275346	63186869
Airway peak pressure increased	42.94	13.78	12	26795	283	63461932
Synovitis	42.56	13.78	13	26794	186905	63275310
Off label use	41.60	13.78	146	26661	674316	62787899
Respiratory rate increased	41.36	13.78	39	26768	13609	63448606
Appetite disorder	41.28	13.78	30	26777	7291	63454924
Respiratory acidosis	41.28	13.78	29	26778	6686	63455529
Drug ineffective	41.16	13.78	266	26541	1044499	62417716
Congestive cardiomyopathy	41.06	13.78	28	26779	6154	63456061
Product use issue	40.93	13.78	21	26786	220499	63241716
Therapeutic product effect decreased	39.59	13.78	16	26791	193171	63269044
PCO2 increased	39.26	13.78	16	26791	1223	63460992
Oligoarthritis	39.08	13.78	13	26794	558	63461657
Rash	39.03	13.78	115	26692	560756	62901459
Lung hyperinflation	38.57	13.78	16	26791	1279	63460936
Female sterilisation	38.14	13.78	13	26794	602	63461613
Arteriosclerosis coronary artery	37.70	13.78	30	26777	8343	63453872
Vital capacity decreased	37.26	13.78	17	26790	1711	63460504
Lipohypertrophy	37.14	13.78	13	26794	652	63461563
Increased viscosity of bronchial secretion	36.78	13.78	11	26796	332	63461883
Sinus pain	36.73	13.78	21	26786	3389	63458826
Decreased bronchial secretion	36.73	13.78	8	26799	63	63462152
Discomfort	35.72	13.78	13	26794	167361	63294854
Acute respiratory failure	35.38	13.78	57	26750	34428	63427787
Emphysema	34.58	13.78	32	26775	10906	63451309
Respiratory tract inflammation	34.47	13.78	12	26795	592	63461623
Blood pressure inadequately controlled	34.14	13.78	23	26784	4955	63457260
PO2 decreased	33.05	13.78	15	26792	1491	63460724
Adrenal suppression	32.97	13.78	13	26794	911	63461304
Eosinophilia	32.58	13.78	44	26763	22712	63439503
Painful respiration	32.36	13.78	18	26789	2756	63459459
Abdominal discomfort	31.94	13.78	54	26753	320831	63141384
Respiratory failure	31.80	13.78	105	26702	101753	63360462
Dyspnoea at rest	30.77	13.78	20	26787	4059	63458156
Asthmatic crisis	30.40	13.78	15	26792	1798	63460417
Eye paraesthesia	30.26	13.78	8	26799	152	63462063
Viral infection	30.05	13.78	54	26753	35609	63426606
Diarrhoea	29.68	13.78	179	26628	715187	62747028
Influenza	29.52	13.78	107	26700	108615	63353600
Full blood count abnormal	29.29	13.78	50	26757	31667	63430548
Blood bicarbonate decreased	28.73	13.78	17	26790	2924	63459291
Stress cardiomyopathy	28.63	13.78	27	26780	9423	63452792
Blood pH decreased	28.05	13.78	16	26791	2571	63459644
Psoriatic arthropathy	28.00	13.78	3	26804	91517	63370698
Glossitis	27.99	13.78	17	26790	3065	63459150
Ligament pain	27.78	13.78	8	26799	211	63462004
Arthropathy	27.77	13.78	35	26772	234757	63227458
Tachycardia	27.73	13.78	111	26696	118045	63344170
Impaired healing	27.53	13.78	5	26802	102537	63359678
Heart rate increased	27.52	13.78	95	26712	94143	63368072
Breast neoplasm	27.49	13.78	13	26794	1419	63460796
Febrile neutropenia	27.38	13.78	8	26799	118441	63343774
Intentional product use issue	27.17	13.78	10	26797	127882	63334333
Left ventricular failure	26.95	13.78	21	26786	5666	63456549
Musculoskeletal stiffness	26.93	13.78	23	26784	184595	63277620
Neutropenia	26.53	13.78	21	26786	174984	63287231
Oxygen saturation decreased	26.48	13.78	90	26717	88495	63373720
Pleural rub	26.17	13.78	6	26801	61	63462154
Stomatitis	26.04	13.78	13	26794	138712	63323503
Lung opacity	25.05	13.78	16	26791	3152	63459063
Depressed level of consciousness	25.01	13.78	70	26737	62008	63400207
Myopathy	24.79	13.78	27	26780	11164	63451051
Paranasal sinus hypersecretion	24.76	13.78	17	26790	3778	63458437
Diabetes mellitus	24.55	13.78	65	26742	55745	63406470
Flail chest	24.41	13.78	6	26801	84	63462131
Diabetes mellitus inadequate control	24.37	13.78	31	26776	15095	63447120
Stress urinary incontinence	24.02	13.78	14	26793	2341	63459874
Lung perforation	23.90	13.78	6	26801	92	63462123
Drug level increased	23.90	13.78	38	26769	22698	63439517
Drug level above therapeutic	23.33	13.78	18	26789	4787	63457428
Respiratory tract congestion	23.31	13.78	33	26774	17799	63444416
Ankle fracture	23.27	13.78	33	26774	17822	63444393
Kyphosis	23.04	13.78	14	26793	2526	63459689
Infective exacerbation of chronic obstructive airways disease	22.88	13.78	11	26796	1246	63460969
Completed suicide	22.68	13.78	17	26790	145656	63316559
Crepitations	22.52	13.78	22	26785	8018	63454197
Spleen congestion	22.45	13.78	6	26801	119	63462096
Pertussis	22.16	13.78	9	26798	682	63461533
Increased bronchial secretion	22.09	13.78	12	26795	1754	63460461
Respiratory symptom	21.85	13.78	15	26792	3332	63458883
Urogenital haemorrhage	21.76	13.78	7	26800	270	63461945
Allergic cough	21.63	13.78	9	26798	725	63461490
Breast conserving surgery	21.61	13.78	10	26797	1039	63461176
Sputum abnormal	21.61	13.78	9	26798	727	63461488
Presbyacusis	21.49	13.78	14	26793	2851	63459364
Pain	21.37	13.78	205	26602	740423	62721792
Hypoventilation	21.33	13.78	17	26790	4737	63457478
Obesity	21.07	13.78	42	26765	29910	63432305
Seizure	21.00	13.78	111	26696	132523	63329692
Pulmonary congestion	20.96	13.78	31	26776	17387	63444828
Overdose	20.82	13.78	100	26707	114978	63347237
Macrocytosis	20.77	13.78	13	26794	2472	63459743
Oesophagogastroduodenoscopy	20.59	13.78	6	26801	165	63462050
Thoracic operation	20.56	13.78	6	26801	166	63462049
Tremor	20.48	13.78	110	26697	132129	63330086
Antasthmatic drug level above therapeutic	20.31	13.78	3	26804	0	63462215
Vomiting	20.22	13.78	340	26467	559277	62902938
Malaise	20.21	13.78	266	26541	415688	63046527
Cyanosis	20.18	13.78	30	26777	16905	63445310
Rhabdomyolysis	20.16	13.78	52	26755	43899	63418316
Latent tuberculosis	20.11	13.78	13	26794	2614	63459601
Blood immunoglobulin E increased	19.97	13.78	15	26792	3834	63458381
Haemoptysis	19.88	13.78	40	26767	28686	63433529
Angina pectoris	19.77	13.78	41	26766	30037	63432178
Blood lactic acid increased	19.12	13.78	19	26788	7067	63455148
Glaucoma	19.05	13.78	31	26776	18874	63443341
Peripheral swelling	18.82	13.78	54	26753	265888	63196327
Disease progression	18.26	13.78	15	26792	122743	63339472
Oropharyngeal candidiasis	18.06	13.78	9	26798	1102	63461113
Muscle injury	17.95	13.78	3	26804	65342	63396873
Injection site hypoaesthesia	17.76	13.78	7	26800	490	63461725
Staphylococcus test positive	17.63	13.78	14	26793	3882	63458333
Hyperventilation	17.62	13.78	17	26790	6099	63456116
Stress	17.30	13.78	65	26742	67102	63395113
Gastrointestinal disorder	17.20	13.78	18	26789	131221	63330994
Bronchitis	16.75	13.78	100	26707	124835	63337380
Hypokalaemia	16.51	13.78	87	26720	103717	63358498
Oedema	16.35	13.78	83	26724	97539	63364676
Rib fracture	16.27	13.78	32	26775	22565	63439650
Food allergy	16.25	13.78	22	26785	11379	63450836
White blood cell count decreased	16.16	13.78	21	26786	139083	63323132
Upper respiratory tract infection	16.08	13.78	73	26734	81974	63380241
Blood cholesterol increased	15.93	13.78	10	26797	94022	63368193
Fibromyalgia	15.92	13.78	7	26800	80413	63381802
Arthralgia	15.85	13.78	159	26648	569551	62892664
Obstruction	15.81	13.78	12	26795	3115	63459100
Anaemia	15.77	13.78	67	26740	293363	63168852
Flank pain	15.32	13.78	26	26781	16384	63445831
Ventricular tachycardia	15.25	13.78	29	26778	19950	63442265
Supraventricular tachycardia	15.20	13.78	24	26783	14247	63447968
Generalised tonic-clonic seizure	15.07	13.78	36	26771	28980	63433235
Dysphonia	14.77	13.78	49	26758	47565	63414650
Mental disability	14.71	13.78	4	26803	85	63462130
Blister	14.67	13.78	20	26787	129794	63332421
Cushingoid	14.64	13.78	18	26789	8467	63453748
Anaphylactic reaction	14.63	13.78	61	26746	66039	63396176
Vaccination site haemorrhage	14.48	13.78	3	26804	18	63462197
Loss of personal independence in daily activities	14.43	13.78	80	26727	97210	63365005
Seasonal allergy	14.29	13.78	29	26778	20921	63441294
Status epilepticus	14.04	13.78	24	26783	15209	63447006
Atopy	13.97	13.78	5	26802	268	63461947
Aortic valve calcification	13.86	13.78	6	26801	533	63461682
Medication error	13.80	13.78	51	26756	52233	63409982

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	628.31	13.96	343	17448	42313	34896827
Wheezing	325.34	13.96	223	17568	41179	34897961
Chronic obstructive pulmonary disease	244.58	13.96	201	17590	48717	34890423
Obstructive airways disorder	204.09	13.96	116	17675	15378	34923762
Right atrial hypertrophy	171.63	13.96	46	17745	759	34938381
Forced expiratory volume decreased	154.47	13.96	59	17732	3144	34935996
Full blood count abnormal	152.23	13.96	103	17688	18565	34920575
Bronchial secretion retention	150.48	13.96	48	17743	1488	34937652
Bronchial wall thickening	147.53	13.96	46	17745	1322	34937818
Dyspnoea	146.24	13.96	471	17320	376311	34562829
Right ventricular hypertrophy	142.34	13.96	46	17745	1488	34937652
Productive cough	137.93	13.96	130	17661	37683	34901457
Therapeutic product effect incomplete	130.15	13.96	144	17647	50397	34888743
Pulmonary function test abnormal	125.58	13.96	48	17743	2562	34936578
Aortic valve stenosis	123.95	13.96	48	17743	2655	34936485
Obstruction	123.67	13.96	48	17743	2671	34936469
Chest X-ray abnormal	113.88	13.96	52	17739	4346	34934794
Sleep disorder due to a general medical condition	111.36	13.96	54	17737	5167	34933973
Loss of personal independence in daily activities	105.83	13.96	106	17685	33073	34906067
Diastolic dysfunction	96.72	13.96	52	17739	6175	34932965
Gastrooesophageal reflux disease	92.36	13.96	105	17686	37819	34901321
Intervertebral disc degeneration	89.75	13.96	50	17741	6367	34932773
Rhinitis perennial	80.77	13.96	21	17770	306	34938834
Cough	77.19	13.96	208	17583	149932	34789208
Vital capacity decreased	77.00	13.96	21	17770	371	34938769
Bronchiectasis	74.95	13.96	52	17739	9749	34929391
Osteoporosis	71.57	13.96	56	17735	12612	34926528
Sputum discoloured	63.40	13.96	43	17748	7769	34931371
Benign prostatic hyperplasia	60.93	13.96	54	17737	14441	34924699
Adjustment disorder	57.46	13.96	22	17769	1179	34937961
Radiation inflammation	55.89	13.96	20	17771	885	34938255
Foetal malformation	54.95	13.96	13	17778	125	34939015
Gout	53.23	13.96	57	17734	19196	34919944
Emphysema	51.42	13.96	41	17750	9484	34929656
Sleep apnoea syndrome	50.69	13.96	57	17734	20264	34918876
Respiratory failure	50.37	13.96	145	17646	108427	34830713
Pulmonary pain	50.01	13.96	20	17771	1204	34937936
Lung diffusion disorder	49.01	13.96	12	17779	135	34939005
Eosinophil count increased	48.65	13.96	38	17753	8534	34930606
Forced vital capacity decreased	47.36	13.96	17	17774	759	34938381
Atrial fibrillation	47.01	13.96	153	17638	122240	34816900
Chest discomfort	46.13	13.96	92	17699	54438	34884702
Mental disability	45.86	13.96	10	17781	64	34939076
Ocular discomfort	45.29	13.96	22	17769	2112	34937028
Hypoacusis	44.60	13.96	48	17743	16253	34922887
Pulmonary function test decreased	44.26	13.96	29	17762	4946	34934194
Off label use	41.98	13.96	95	17696	419429	34519711
Hypercapnia	40.80	13.96	26	17765	4229	34934911
Fungal disease carrier	40.65	13.96	12	17779	285	34938855
Inguinal hernia repair	39.80	13.96	12	17779	307	34938833
Anxiety	39.71	13.96	126	17665	99302	34839838
Seasonal allergy	38.77	13.96	30	17761	6645	34932495
Oropharyngeal candidiasis	35.49	13.96	14	17777	813	34938327
Bronchial obstruction	35.32	13.96	17	17774	1599	34937541
Total lung capacity abnormal	33.49	13.96	9	17782	150	34938990
Trisomy 18	32.90	13.96	13	17778	758	34938382
Supraventricular tachycardia	32.65	13.96	34	17757	11083	34928057
Diarrhoea	32.30	13.96	97	17694	389815	34549325
Eosinophilic granulomatosis with polyangiitis	31.99	13.96	17	17774	1970	34937170
Dyspnoea exertional	31.88	13.96	69	17722	43210	34895930
Neutropenia	30.86	13.96	21	17770	156757	34782383
Eosinophilic bronchitis	30.44	13.96	9	17782	215	34938925
Dermatitis allergic	29.81	13.96	26	17765	6804	34932336
Febrile neutropenia	28.75	13.96	17	17774	136832	34802308
Hypercholesterolaemia	27.92	13.96	28	17763	8734	34930406
Obesity	26.92	13.96	33	17758	12845	34926295
Tachycardia foetal	26.66	13.96	9	17782	334	34938806
Wolff-Parkinson-White syndrome	26.05	13.96	8	17783	218	34938922
Blood immunoglobulin E increased	25.52	13.96	16	17775	2530	34936610
Foetal distress syndrome	25.34	13.96	12	17779	1088	34938052
Pain	25.05	13.96	41	17750	204634	34734506
Lung hyperinflation	24.43	13.96	11	17780	889	34938251
Pancytopenia	24.33	13.96	9	17782	95148	34843992
Sputum increased	24.02	13.96	15	17776	2355	34936785
Lower respiratory tract infection	23.94	13.96	51	17740	31586	34907554
Glaucoma	23.72	13.96	23	17768	6889	34932251
Tachycardia	23.21	13.96	95	17696	84677	34854463
Pneumonia	22.38	13.96	282	17509	362345	34576795
Eye pruritus	22.16	13.96	23	17768	7466	34931674
Lung neoplasm malignant	21.98	13.96	35	17756	17360	34921780
Pulmonary artery dilatation	21.61	13.96	7	17784	228	34938912
Hypoxia	21.22	13.96	69	17722	55026	34884114
Supraventricular extrasystoles	20.88	13.96	16	17775	3492	34935648
Conduction disorder	20.50	13.96	13	17778	2097	34937043
Product use in unapproved indication	20.24	13.96	18	17773	117481	34821659
Reversible airways obstruction	20.01	13.96	8	17783	481	34938659
Neuropathy peripheral	19.46	13.96	9	17782	83254	34855886
Schizophrenia	19.41	13.96	23	17768	8643	34930497
Status asthmaticus	19.18	13.96	7	17784	328	34938812
Arthralgia	19.04	13.96	36	17755	170005	34769135
Arrhythmia	18.72	13.96	50	17741	35758	34903382
Tachyarrhythmia	18.35	13.96	15	17776	3593	34935547
Drug level increased	18.33	13.96	37	17754	22059	34917081
Stenotrophomonas infection	18.04	13.96	12	17779	2098	34937042
Acute kidney injury	17.99	13.96	87	17704	304901	34634239
Dizziness exertional	17.92	13.96	6	17785	217	34938923
Ventricular extrasystoles	17.77	13.96	26	17765	11982	34927158
Thrombocytopenia	17.56	13.96	33	17758	156214	34782926
Perfume sensitivity	17.34	13.96	5	17786	109	34939031
Sudden infant death syndrome	17.30	13.96	6	17785	242	34938898
Cardiac failure congestive	17.29	13.96	86	17705	83184	34855956
Lung neoplasm	16.95	13.96	16	17775	4635	34934505
Respiratory disorder	16.87	13.96	33	17758	19231	34919909
Lung opacity	16.83	13.96	12	17779	2347	34936793
Post streptococcal glomerulonephritis	16.81	13.96	5	17786	122	34939018
Carbon dioxide increased	16.71	13.96	9	17782	1072	34938068
Breath sounds abnormal	16.64	13.96	19	17772	6862	34932278
Eosinophilic pneumonia chronic	16.28	13.96	6	17785	289	34938851
Somnambulism	16.10	13.96	13	17778	3059	34936081
Tonic convulsion	15.82	13.96	9	17782	1192	34937948
Haemophilus infection	15.68	13.96	9	17782	1212	34937928
Death	15.51	13.96	129	17662	397920	34541220
Knee arthroplasty	15.43	13.96	19	17772	7425	34931715
Cushingoid	15.33	13.96	12	17779	2702	34936438
Back pain	15.25	13.96	24	17767	121765	34817375
Axial spondyloarthritis	15.25	13.96	6	17785	346	34938794
Unmasking of previously unidentified disease	15.23	13.96	8	17783	906	34938234
Lipid metabolism disorder	15.18	13.96	6	17785	350	34938790
Discomfort	14.87	13.96	31	17760	18907	34920233
Gastrointestinal necrosis	14.85	13.96	13	17778	3416	34935724
Nikolsky's sign	14.55	13.96	5	17786	196	34938944
Loss of proprioception	14.51	13.96	6	17785	394	34938746
Vitamin D increased	14.49	13.96	4	17787	74	34939066
Depressed mood	14.45	13.96	31	17760	19286	34919854
Epidural lipomatosis	14.16	13.96	8	17783	1046	34938094

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	1002.69	12.47	697	39152	134398	79570141
Wheezing	716.56	12.47	537	39312	116127	79588412
Chronic obstructive pulmonary disease	356.22	12.47	314	39535	85105	79619434
Productive cough	285.83	12.47	282	39567	88049	79616490
Dyspnoea	283.91	12.47	1004	38845	856021	78848518
Forced expiratory volume decreased	241.38	12.47	104	39745	7710	79696829
Obstructive airways disorder	236.56	12.47	164	39685	31295	79673244
Sleep disorder due to a general medical condition	181.92	12.47	104	39745	14173	79690366
Cough	169.43	12.47	483	39366	366306	79338233
Sputum discoloured	164.97	12.47	114	39735	21629	79682910
Right atrial hypertrophy	164.88	12.47	44	39805	727	79703812
Pulmonary pain	152.97	12.47	64	39785	4409	79700130
Right ventricular hypertrophy	132.18	12.47	44	39805	1593	79702946
Obstruction	128.23	12.47	57	39792	4553	79699986
Bronchial wall thickening	125.85	12.47	48	39801	2593	79701946
Full blood count abnormal	124.86	12.47	126	39723	40348	79664191
Rales	120.08	12.47	91	39758	19910	79684629
Chest discomfort	113.88	12.47	228	39621	137816	79566723
Breath sounds abnormal	112.39	12.47	80	39769	15904	79688635
Bronchial neoplasm	108.68	12.47	29	39820	479	79704060
Sinus tachycardia	106.78	12.47	111	39738	36797	79667742
Pulmonary function test abnormal	104.97	12.47	48	39801	4096	79700443
Hypercapnia	103.00	12.47	61	39788	8874	79695665
Aortic valve stenosis	102.58	12.47	51	39798	5243	79699296
Bronchial secretion retention	102.28	12.47	47	39802	4057	79700482
Nasal congestion	100.30	12.47	155	39694	76397	79628142
Nasal turbinate hypertrophy	98.87	12.47	29	39820	686	79703853
Nasal oedema	95.53	12.47	35	39814	1689	79702850
Endometrial ablation	92.51	12.47	29	39820	864	79703675
Pneumonia	91.51	12.47	603	39246	659643	79044896
Eosinophil count increased	85.80	12.47	70	39779	17035	79687504
Loss of personal independence in daily activities	85.25	12.47	170	39679	102410	79602129
Bronchial obstruction	82.73	12.47	36	39813	2732	79701807
Heart sounds	82.14	12.47	27	39822	939	79703600
Rhonchi	81.53	12.47	40	39809	3996	79700543
Bronchial haemorrhage	81.39	12.47	29	39820	1291	79703248
Chest X-ray abnormal	81.02	12.47	50	39799	7833	79696706
Emphysema	76.12	12.47	64	39785	16236	79688303
Therapeutic product effect incomplete	75.63	12.47	197	39652	141448	79563091
Prolonged expiration	74.89	12.47	27	39822	1244	79703295
Rhinitis perennial	74.74	12.47	20	39829	334	79704205
Lower respiratory tract infection	74.48	12.47	185	39664	129035	79575504
Alopecia	74.33	12.47	13	39836	231342	79473197
Bronchial disorder	69.95	12.47	31	39818	2458	79702081
Mental disability	69.93	12.47	14	39835	56	79704483
Status asthmaticus	68.64	12.47	24	39825	1010	79703529
Diastolic dysfunction	66.69	12.47	50	39799	10761	79693778
Off label use	66.54	12.47	232	39617	906983	78797556
Benign prostatic hyperplasia	65.68	12.47	51	39798	11561	79692978
Rhinitis	62.76	12.47	55	39794	14752	79689787
Dyspnoea exertional	62.61	12.47	136	39713	86937	79617602
Neutropenia	60.90	12.47	34	39815	287676	79416863
Depressed mood	60.48	12.47	96	39753	48384	79656155
Sleep apnoea syndrome	59.59	12.47	82	39767	36396	79668143
Respiratory failure	59.28	12.47	212	39637	180699	79523840
Respiratory tract infection	58.80	12.47	95	39754	48594	79655945
Lung hyperinflation	58.25	12.47	25	39824	1834	79702705
Febrile neutropenia	57.07	12.47	22	39827	230977	79473562
Atrial fibrillation	56.61	12.47	222	39627	197664	79506875
Radiation inflammation	56.24	12.47	20	39829	885	79703654
Diarrhoea	55.03	12.47	240	39609	880249	78824290
Respiratory disorder	54.82	12.47	88	39761	44768	79659771
Respiration abnormal	54.79	12.47	39	39810	7749	79696790
Rheumatoid arthritis	54.67	12.47	18	39831	208452	79496087
Infusion related reaction	53.54	12.47	24	39825	230213	79474326
Eosinophilic granulomatosis with polyangiitis	52.98	12.47	29	39820	3631	79700908
Hepatic enzyme increased	51.08	12.47	14	39835	182596	79521943
Gout	50.35	12.47	62	39787	24687	79679852
Bronchiectasis	50.32	12.47	59	39790	22327	79682212
Intervertebral disc degeneration	50.25	12.47	50	39799	15735	79688804
Osteoporosis	50.22	12.47	94	39755	54018	79650521
Oropharyngeal candidiasis	49.75	12.47	22	39827	1735	79702804
Joint swelling	49.33	12.47	43	39806	288603	79415936
Seasonal allergy	48.63	12.47	50	39799	16356	79688183
Neurosensory hypoacusis	48.59	12.47	13	39836	217	79704322
Systemic lupus erythematosus	48.57	12.47	3	39846	121146	79583393
Bronchospasm	48.53	12.47	61	39788	24798	79679741
Amyloid arthropathy	48.47	12.47	16	39833	564	79703975
Lung diffusion disorder	45.80	12.47	12	39837	184	79704355
Fatigue	44.79	12.47	277	39572	929450	78775089
Middle insomnia	44.10	12.47	47	39802	16022	79688517
Airway peak pressure increased	43.34	12.47	13	39836	333	79704206
Obesity	43.04	12.47	69	39780	35056	79669483
Rhinorrhoea	42.85	12.47	108	39741	75966	79628573
Tachycardia	41.90	12.47	188	39661	177580	79526959
Supraventricular tachycardia	41.21	12.47	52	39797	21218	79683321
Gastrooesophageal reflux disease	41.06	12.47	130	39719	104116	79600423
Treatment failure	40.85	12.47	17	39832	170469	79534070
Respiratory rate increased	40.57	12.47	52	39797	21548	79682991
Forced vital capacity decreased	40.44	12.47	19	39830	1724	79702815
Depressive symptom	40.27	12.47	30	39819	6393	79698146
Toxicity to various agents	40.15	12.47	353	39496	421187	79283352
Intentional product use issue	40.10	12.47	13	39836	152099	79552440
Product use issue	39.96	12.47	28	39821	209794	79494745
Pulmonary function test decreased	39.87	12.47	32	39817	7605	79696934
Inguinal hernia repair	39.61	12.47	12	39837	318	79704221
Synovitis	39.53	12.47	13	39836	150721	79553818
Hypoacusis	39.40	12.47	61	39788	30089	79674450
Fungal disease carrier	38.72	12.47	12	39837	344	79704195
Pericarditis	37.85	12.47	4	39845	104232	79600307
Granuloma	37.55	12.47	32	39817	8265	79696274
Affective disorder	37.48	12.47	32	39817	8287	79696252
Glossodynia	37.44	12.47	4	39845	103333	79601206
Vital capacity decreased	36.69	12.47	18	39831	1798	79702741
Therapeutic product effect decreased	36.67	12.47	18	39831	163845	79540694
Respiratory acidosis	36.62	12.47	36	39813	11164	79693375
PCO2 increased	36.46	12.47	18	39831	1822	79702717
Drug level increased	35.70	12.47	68	39781	39583	79664956
Decreased bronchial secretion	35.16	12.47	8	39841	65	79704474
Congestive cardiomyopathy	35.09	12.47	36	39813	11744	79692795
Multiple drug therapy	34.79	12.47	23	39826	4055	79700484
Oligoarthritis	33.93	12.47	13	39836	711	79703828
Hypercholesterolaemia	33.41	12.47	49	39800	23046	79681493
Appetite disorder	33.30	12.47	29	39820	7710	79696829
Exercise tolerance decreased	33.14	12.47	31	39818	9040	79695499
Increased viscosity of bronchial secretion	33.09	12.47	12	39837	562	79703977
Stomatitis	33.02	12.47	16	39833	146741	79557798
Adjustment disorder	32.77	12.47	22	39827	3978	79700561
Sinus pain	31.67	12.47	21	39828	3721	79700818
Blood immunoglobulin E increased	31.46	12.47	25	39824	5857	79698682
PO2 decreased	30.97	12.47	19	39830	2944	79701595
Hypoventilation	30.95	12.47	27	39822	7197	79697342
Blood pressure inadequately controlled	30.39	12.47	25	39824	6152	79698387
Anaemia	30.38	12.47	117	39732	444898	79259641
Impaired healing	30.25	12.47	4	39845	87651	79616888
Blood pH decreased	29.53	12.47	22	39827	4689	79699850
Asthmatic crisis	29.33	12.47	16	39833	1990	79702549
Wound	28.79	12.47	11	39838	116168	79588371
Drug interaction	28.52	12.47	325	39524	414858	79289681
Respiratory tract inflammation	28.28	12.47	12	39837	856	79703683
Lipohypertrophy	28.07	12.47	12	39837	872	79703667
Influenza	27.53	12.47	133	39716	129473	79575066
Thrombocytopenia	27.52	12.47	57	39792	265202	79439337
Arrhythmia	27.48	12.47	80	39769	61192	79643347
Breast neoplasm	27.46	12.47	12	39837	920	79703619
Rash	27.40	12.47	173	39676	578185	79126354
Eosinophilic bronchitis	27.30	12.47	10	39839	482	79704057
Medication error	26.47	12.47	85	39764	68557	79635982
Pain	26.40	12.47	225	39624	703577	79000962
Pulmonary congestion	26.30	12.47	48	39801	27052	79677487
Cyanosis	26.23	12.47	46	39803	25136	79679403
Acute respiratory failure	26.00	12.47	77	39772	59464	79645075
Supraventricular extrasystoles	25.76	12.47	24	39825	6963	79697576
Drug ineffective	25.44	12.47	384	39465	1080529	78624010
Neuropathy peripheral	25.41	12.47	20	39829	141285	79563254
Acute kidney injury	25.30	12.47	154	39695	519250	79185289
Ligament pain	25.15	12.47	8	39841	250	79704289
Kyphosis	24.97	12.47	16	39833	2675	79701864
Pleural rub	24.90	12.47	6	39843	64	79704475
Arteriosclerosis coronary artery	24.62	12.47	37	39812	17779	79686760
Pancytopenia	24.50	12.47	28	39821	165717	79538822
Heart rate increased	24.29	12.47	122	39727	120602	79583937
Respiratory tract congestion	24.17	12.47	39	39810	19915	79684624
Wolff-Parkinson-White syndrome	23.89	12.47	8	39841	295	79704244
Swelling	23.83	12.47	45	39804	216666	79487873
Eosinophilic pneumonia chronic	23.20	12.47	9	39840	509	79704030
Arthralgia	23.16	12.47	179	39670	571624	79132915
Dyspnoea at rest	23.00	12.47	23	39826	7279	79697260
Cushingoid	22.85	12.47	26	39823	9526	79695013
Overdose	22.83	12.47	164	39685	184042	79520497
Adrenal suppression	22.82	12.47	12	39837	1387	79703152
Flail chest	22.49	12.47	6	39843	99	79704440
Gastrointestinal disorder	22.35	12.47	17	39832	122188	79582351
Seizure	22.19	12.47	166	39683	188668	79515871
Helicobacter infection	22.19	12.47	4	39845	69700	79634839
Lung perforation	22.05	12.47	6	39843	107	79704432
Paranasal sinus hypersecretion	21.98	12.47	17	39832	3829	79700710
Total lung capacity abnormal	21.70	12.47	7	39842	229	79704310
Blood bicarbonate decreased	21.43	12.47	19	39830	5172	79699367
Drug level above therapeutic	21.30	12.47	24	39825	8699	79695840
Stress cardiomyopathy	21.16	12.47	27	39822	11139	79693400
Viral infection	21.08	12.47	58	39791	42958	79661581
Clonic convulsion	21.08	12.47	11	39838	1251	79703288
Allergic cough	20.54	12.47	9	39840	694	79703845
Product use in unapproved indication	20.34	12.47	61	39788	250298	79454241
Generalised tonic-clonic seizure	20.34	12.47	58	39791	43852	79660687
Ankle fracture	20.33	12.47	33	39816	16936	79687603
Tachyarrhythmia	20.24	12.47	21	39828	6941	79697598
Tonic convulsion	20.11	12.47	13	39836	2207	79702332
Eye paraesthesia	19.84	12.47	6	39843	158	79704381
Gastric atony	19.81	12.47	3	39846	0	79704539
Antasthmatic drug level above therapeutic	19.81	12.47	3	39846	0	79704539
Breast conserving surgery	19.54	12.47	9	39840	781	79703758
Death	19.51	12.47	185	39664	566329	79138210
Sputum increased	19.28	12.47	17	39832	4596	79699943
Eosinophilic pneumonia	19.12	12.47	18	39831	5292	79699247
Pertussis	18.66	12.47	9	39840	866	79703673
Perfume sensitivity	18.62	12.47	9	39840	870	79703669
Electrocardiogram ST segment depression	18.46	12.47	17	39832	4861	79699678
Eosinophilia	18.26	12.47	57	39792	45288	79659251
Ocular discomfort	18.15	12.47	17	39832	4966	79699573
Ventricular extrasystoles	17.99	12.47	34	39815	19670	79684869
Presbyacusis	17.98	12.47	13	39836	2647	79701892
Thoracic operation	17.92	12.47	6	39843	221	79704318
Left ventricular failure	17.89	12.47	23	39826	9558	79694981
Status epilepticus	17.86	12.47	39	39810	25002	79679537
Bronchitis chronic	17.70	12.47	16	39833	4466	79700073
Increased bronchial secretion	17.49	12.47	14	39835	3313	79701226
White blood cell count decreased	17.45	12.47	43	39806	188245	79516294
Stevens-Johnson syndrome	17.43	12.47	51	39798	39115	79665424
Oesophagogastroduodenoscopy	17.43	12.47	6	39843	241	79704298
Chest pain	17.16	12.47	216	39633	282088	79422451
Completed suicide	17.14	12.47	64	39785	245703	79458836
Crepitations	17.08	12.47	23	39826	9994	79694545
Nasal septum deviation	17.04	12.47	11	39838	1862	79702677
Pulmonary artery dilatation	17.01	12.47	7	39842	462	79704077
Toxic epidermal necrolysis	17.00	12.47	55	39794	44526	79660013
Musculoskeletal stiffness	16.99	12.47	39	39810	174969	79529570
Septic shock	16.82	12.47	22	39827	122779	79581760
Post streptococcal glomerulonephritis	16.74	12.47	5	39844	126	79704413
Glaucoma	16.70	12.47	33	39816	19728	79684811
Sudden infant death syndrome	16.59	12.47	6	39843	279	79704260
Bronchitis	16.58	12.47	117	39732	130527	79574012
Hypokalaemia	16.57	12.47	126	39723	143914	79560625
Drug intolerance	16.40	12.47	72	39777	264047	79440492
Lung neoplasm malignant	16.21	12.47	40	39809	27752	79676787
Fibromyalgia	16.09	12.47	6	39843	64334	79640205
Oxygen saturation decreased	16.04	12.47	115	39734	128932	79575607
Injection site hypoaesthesia	16.01	12.47	7	39842	537	79704002
Enterobacter pneumonia	15.98	12.47	5	39844	148	79704391
Nasal polyps	15.95	12.47	19	39830	7308	79697231
Paraesthesia	15.77	12.47	41	39808	176282	79528257
Disease progression	15.64	12.47	44	39805	184318	79520221
Diabetes mellitus	15.61	12.47	79	39770	78311	79626228
Sputum abnormal	15.54	12.47	9	39840	1256	79703283
Lipid metabolism disorder	15.40	12.47	6	39843	343	79704196
Ventricular tachycardia	15.33	12.47	51	39798	41884	79662655
Latent tuberculosis	15.31	12.47	13	39836	3340	79701199
Irritable bowel syndrome	15.24	12.47	6	39843	62235	79642304
Haematochezia	15.02	12.47	13	39836	87632	79616907
Macrocytosis	14.93	12.47	12	39837	2858	79701681
Respiratory symptom	14.92	12.47	15	39834	4776	79699763
Leukopenia	14.83	12.47	22	39827	116491	79588048
Peripheral swelling	14.69	12.47	77	39772	269540	79434999
Ventricular arrhythmia	14.62	12.47	20	39829	8820	79695719
Hypoxia	14.62	12.47	95	39754	103148	79601391
Night sweats	14.55	12.47	4	39845	52091	79652448
Neoplasm progression	14.37	12.47	4	39845	51678	79652861
Deep vein thrombosis	14.28	12.47	24	39825	120895	79583644
Upper respiratory tract infection	14.22	12.47	86	39763	91082	79613457
Multiple sclerosis relapse	14.12	12.47	3	39846	46530	79658009
Bronchitis bacterial	14.11	12.47	9	39840	1493	79703046
Malaise	14.06	12.47	332	39517	489537	79215002
Stenotrophomonas infection	13.99	12.47	13	39836	3760	79700779
Vaccination site haemorrhage	13.98	12.47	3	39846	18	79704521
Dermatitis allergic	13.81	12.47	29	39820	18101	79686438
Burns third degree	13.79	12.47	6	39843	455	79704084
Duodenal ulcer perforation	13.74	12.47	8	39841	66203	79638336
Stress	13.65	12.47	77	39772	79535	79625004
Ill-defined disorder	13.61	12.47	8	39841	65867	79638672
Urinary tract infection	13.54	12.47	81	39768	274431	79430108
Psoriasis	13.38	12.47	15	39834	89572	79614967
Hyperventilation	13.26	12.47	18	39831	7881	79696658
Lung neoplasm	13.25	12.47	17	39832	7052	79697487
Hyperkalaemia	13.24	12.47	23	39826	114375	79590164
Diabetes mellitus inadequate control	13.19	12.47	34	39815	24230	79680309
Pulmonary mass	13.10	12.47	38	39811	28996	79675543
Dry skin	13.03	12.47	9	39840	67986	79636553
Contraindicated product prescribed	12.99	12.47	9	39840	1712	79702827
Alanine aminotransferase increased	12.92	12.47	40	39809	162530	79542009
Food allergy	12.90	12.47	21	39828	10803	79693736
Haemophilus infection	12.88	12.47	10	39839	2266	79702273
Platelet count decreased	12.73	12.47	52	39797	194612	79509927
Transaminases increased	12.65	12.47	5	39844	51738	79652801
Dizziness exertional	12.53	12.47	6	39843	568	79703971
Respiratory alkalosis	12.52	12.47	13	39836	4298	79700241

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03DA04	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
ATC	R03DA05	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
ATC	R03DA54	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
ATC	R03DA55	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
ATC	R03DA74	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines
ATC	R03DB04	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines and adrenergics
ATC	R03DB05	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines and adrenergics
FDA CS	M0023046	Xanthines
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:38147	cardiotonic drugs
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002316	Cardiotonic Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D010726	Phosphodiesterase Inhibitors
MeSH PA	D020011	Protective Agents
MeSH PA	D058914	Purinergic Antagonists
MeSH PA	D058915	Purinergic P1 Receptor Antagonists
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D014665	Vasodilator Agents
FDA EPC	N0000175790	Methylxanthine
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50218	phosphodiesterase inhibitors
CHEBI has role	CHEBI:50846	Immunologic factor
CHEBI has role	CHEBI:51371	muscle relaxants
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:71232	adenosine receptor antagonists
CHEBI has role	CHEBI:76946	fungal metabolites
CHEBI has role	CHEBI:85234	human blood serum metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bronchospasm	indication	4386001
Disorder of lung	indication	19829001	DOID:850
Bronchitis	indication	32398004	DOID:6132
Pulmonary emphysema	indication	87433001
Asthma	indication	195967001	DOID:2841
Asthma night-time symptoms	indication	395022009
Asthma management	indication	406162001
Acute exacerbation of asthma	indication	708038006
Asthma-chronic obstructive pulmonary disease overlap syndrome	indication	10692761000119107
COPD Associated with Chronic Bronchitis	indication
Chronic Obstructive Pulmonary Disease with Bronchospasms	indication
Apnea in the newborn	off-label use	13094009
Neonatal Mixed Apnea	off-label use
Goiter	contraindication	3716002	DOID:12176
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Alcoholism	contraindication	7200002
Hyperammonemia	contraindication	9360008
Peptic ulcer	contraindication	13200003	DOID:750
Hepatic encephalopathy	contraindication	13920009	DOID:13413
Hyperkalemia	contraindication	14140009
Pulmonary edema	contraindication	19242006	DOID:11396
Hashimoto thyroiditis	contraindication	21983002
Myocardial infarction	contraindication	22298006	DOID:5844
Acute tuberculosis	contraindication	25629007
Shock	contraindication	27942005
Hyperthyroidism	contraindication	34486009	DOID:7998
Depressive disorder	contraindication	35489007
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypothyroidism	contraindication	40930008	DOID:1459
Third trimester pregnancy	contraindication	41587001
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Multiple organ failure	contraindication	57653000
Hepatic failure	contraindication	59927004
Poisoning by phenobarbital	contraindication	64921004
Substance abuse	contraindication	66214007
Psychotic disorder	contraindication	69322001
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Sleep apnea	contraindication	73430006	DOID:0050847
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Dermatitis herpetiformis	contraindication	111196000	DOID:8505
Seizure disorder	contraindication	128613002
Cystic fibrosis	contraindication	190905008	DOID:1485
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Sepsis syndrome	contraindication	238150007
Hypocomplementemic urticarial vasculitis	contraindication	239945009
Benign prostatic hyperplasia	contraindication	266569009
Dyspnea	contraindication	267036007
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Continuous fever	contraindication	271751000
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Smoking cessation assistance	contraindication	384742004
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Porphyria	contraindication	418470004
Hypertensive urgency	contraindication	443482000
Smokes tobacco daily	contraindication	449868002
Severe Hypoxemia	contraindication
Theophylline Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.46	acidic
pKa2	3.01	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Enzyme	Q14432	PDE3A_HUMAN	INHIBITOR	Ki	3.85	WOMBAT-PK	CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Enzyme	P27815	PDE4A_HUMAN	INHIBITOR	Ki	4.11	WOMBAT-PK	CHEMBL
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN	ANTAGONIST	Ki	9.22	CHEMBL	CHEMBL
Adenosine receptor A2b	GPCR	P29275	AA2BR_HUMAN	ANTAGONIST	Ki	5.57	CHEMBL	CHEMBL
Adenosine receptor A2a	GPCR	P29274	AA2AR_HUMAN	ANTAGONIST	Ki	9.22	CHEMBL	CHEMBL
Transmembrane domain-containing protein TMIGD3	Unclassified	P0DMS9	TMIG3_HUMAN		Ki	4.06	CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN	ANTAGONIST	Ki	7.85	CHEMBL
Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	P05186	PPBT_HUMAN		Ki	4.09	CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Kinase	O00329	PK3CD_HUMAN		IC50	4.12	CHEMBL
Adenosine receptor A2a	GPCR		AA2AR_RAT		Ki	5.17	CHEMBL
Uncharacterized protein	Enzyme		E1BN64_BOVIN		Ki	4.11	CHEMBL
Adenosine receptor A3	GPCR		AA3R_RAT		Ki	4.07	CHEMBL
Adenosine receptor A1	GPCR		AA1R_BOVIN		Ki	5.42	CHEMBL
Adenosine receptor A1	GPCR		AA1R_CAVPO		Ki	5.01	CHEMBL
Adenosine A2 receptor	GPCR		AA2BR_RAT AA2AR_RAT		Ki	5.88	CHEMBL
Adenosine A2b receptor	GPCR		AA2BR_RAT		Ki	4.82	CHEMBL
Adenosine receptor	GPCR		AA1R_RAT AA3R_RAT AA2BR_RAT AA2AR_RAT		Ki	4.70	CHEMBL
Heart phosphodiesterase	Enzyme		E1BN64_BOVIN PDE1A_BOVIN PDE1B_BOVIN		IC50	4.04	CHEMBL
Adenosine A2a receptor	GPCR		AA2AR_CAVPO		Ki	4.89	CHEMBL
Adenosine receptor A2b	GPCR		AA2BR_MOUSE	ANTAGONIST	Ki	5.25	IUPHAR
Adenosine receptor A1	GPCR		AA1R_RAT		Ki	6.15	CHEMBL

External reference:

ID	Source
4018056	VUID
N0000146397	NUI
D00227	KEGG_DRUG
317-34-0	SECONDARY_CAS_RN
5897-66-5	SECONDARY_CAS_RN
4018055	VANDF
4018056	VANDF
4018129	VANDF
4018130	VANDF
4018132	VANDF
C0039771	UMLSCUI
CHEBI:28177	CHEBI
TEP	PDB_CHEM_ID
CHEMBL190	ChEMBL_ID
DB00277	DRUGBANK_ID
CHEMBL1370561	ChEMBL_ID
D013806	MESH_DESCRIPTOR_UI
2153	PUBCHEM_CID
413	IUPHAR_LIGAND_ID
8000-10-0	SECONDARY_CAS_RN
C137DTR5RG	UNII
DB01223	DRUGBANK_ID
10438	RXNORM
2086	MMSL
3058	MMSL
4172	MMSL
4173	MMSL
4175	MMSL
5563	MMSL
5564	MMSL
674	MMSL
72114	MMSL
72147	MMSL
d00142	MMSL
d00758	MMSL
000602	NDDF
000603	NDDF
000607	NDDF
000608	NDDF
111131008	SNOMEDCT_US
372810006	SNOMEDCT_US
373508009	SNOMEDCT_US
387431001	SNOMEDCT_US
45940009	SNOMEDCT_US
55867006	SNOMEDCT_US
66493003	SNOMEDCT_US
D000628	MESH_DESCRIPTOR_UI
D031210	MESH_DESCRIPTOR_UI
CHEMBL1200578	ChEMBL_ID
376	INN_ID
5967-84-0	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0820	SOLUTION	80 mg	ORAL	ANDA	25 sections
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0820	SOLUTION	80 mg	ORAL	ANDA	25 sections
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0820	SOLUTION	80 mg	ORAL	ANDA	25 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4794	SOLUTION	80 mg	ORAL	ANDA	25 sections
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4820	SOLUTION	80 mg	ORAL	ANDA	25 sections
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4820	SOLUTION	80 mg	ORAL	ANDA	25 sections
THEOPHYLLINE	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4820	SOLUTION	80 mg	ORAL	ANDA	25 sections
Theophylline in Dextrose	HUMAN PRESCRIPTION DRUG LABEL	2	0264-9554	INJECTION, SOLUTION	80 mg	INTRAVENOUS	NDA	27 sections
Theophylline(Anhydrous)	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0486	TABLET, EXTENDED RELEASE	400 mg	ORAL	ANDA	22 sections
Theophylline(Anhydrous)	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0487	TABLET, EXTENDED RELEASE	600 mg	ORAL	ANDA	22 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9813	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	12 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9813	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	12 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9814	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	12 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9814	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	12 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9814	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	12 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0409-5921	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	22 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0409-5921	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	22 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0409-5922	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	22 sections
Aminophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0409-5922	INJECTION, SOLUTION	25 mg	INTRAVENOUS	ANDA	22 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0480-3309	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	22 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0480-3309	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	22 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0480-3310	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	22 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	0480-3310	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	22 sections
Theophylline Extended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0615-1590	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	23 sections
Theophylline Extended Release	HUMAN PRESCRIPTION DRUG LABEL	1	0615-2503	TABLET, EXTENDED RELEASE	200 mg	ORAL	ANDA	23 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	10135-604	SOLUTION	80 mg	ORAL	ANDA	22 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0038	SOLUTION	80 mg	ORAL	ANDA	13 sections
ELIXOPHYLLIN	Human Prescription Drug Label	1	17856-0644	LIQUID	80 mg	ORAL	ANDA	21 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	23155-741	TABLET, EXTENDED RELEASE	300 mg	ORAL	ANDA	12 sections
Theophylline	HUMAN PRESCRIPTION DRUG LABEL	1	23155-742	TABLET, EXTENDED RELEASE	450 mg	ORAL	ANDA	12 sections