protirelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
thyrotropin releasing hormone analogues	2316	24305-27-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

protirelin tartrate
protirelin
lopremone
rifathyroin
rifotironin
TRH

Molecular weight: 362.39
Formula: C16H22N6O4
CLOGP: -2.78
LIPINSKI: 0
HAC: 10
HDO: 4
TPSA: 150.28
ALOGS: -1.95
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	2 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Nov. 5, 1976	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V04CJ02	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for thyreoidea function
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diagnostic Test for Thyroid Dysfunction	indication
Pituitary Function Studies	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.66	acidic
pKa2	13.44	acidic
pKa3	6.3	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Thyrotropin-releasing hormone receptor	GPCR	P34981	TRFR_HUMAN	AGONIST	Ki	7.70		CHEMBL	CHEMBL
Thyrotropin-releasing hormone receptor	GPCR		TRFR_RAT		Ki	7.70		CHEMBL
Protein Trhr2; Thyrotropin releasing hormone receptor 2; Thyrotropin-releasing hormone receptor 2	GPCR		Q9R297_RAT		Ki	8		CHEMBL
Thyrotropin-releasing hormone receptor	GPCR		TRFR_MOUSE		Ki	8		CHEMBL
Thyrotropin-releasing hormone receptor 2	GPCR		Q9ERT1_MOUSE		IC50	8.15		CHEMBL

External reference:

ID	Source
4018469	VUID
N0000170390	NUI
D00176	KEGG_DRUG
53935-32-3	SECONDARY_CAS_RN
4018469	VANDF
C0040162	UMLSCUI
CHEBI:35940	CHEBI
CHEMBL1472	ChEMBL_ID
DB09421	DRUGBANK_ID
638678	PUBCHEM_CID
3335	INN_ID
5Y5F15120W	UNII
10580	RXNORM
5380	MMSL
d03679	MMSL
002111	NDDF
10534002	SNOMEDCT_US
412495007	SNOMEDCT_US
412496008	SNOMEDCT_US
73805002	SNOMEDCT_US
2139	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Thyrotropin Releasing HormoneTRH	HUMAN PRESCRIPTION DRUG LABEL	1	51808-209	SOLUTION	500 ug	INTRAVENOUS	Unapproved drug other	9 sections