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protirelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| thyrotropin releasing hormone analogues | 2316 | 24305-27-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | AXL,CDK5,CDK9,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC | 9 | |||
| kinase-selectivity-class | PDK1 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 5, 1976 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V04CJ02 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for thyreoidea function |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:77746 | human metabolite |
Related Drugs by ATC class:
V04CJ Tests for thyreoidea function 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diagnostic Test for Thyroid Dysfunction | indication | ||
| Pituitary Function Studies | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.66 | acidic |
| pKa2 | 13.44 | acidic |
| pKa3 | 6.3 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thyrotropin-releasing hormone receptor | GPCR | AGONIST | Ki | 7.70 | CHEMBL | CHEMBL | |||
| Thyrotropin-releasing hormone receptor | GPCR | Ki | 7.70 | CHEMBL | |||||
| Protein Trhr2; Thyrotropin releasing hormone receptor 2; Thyrotropin-releasing hormone receptor 2 | GPCR | Ki | 8 | CHEMBL | |||||
| Thyrotropin-releasing hormone receptor | GPCR | Ki | 8 | CHEMBL | |||||
| Thyrotropin-releasing hormone receptor 2 | GPCR | IC50 | 8.15 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018469 | VUID |
| N0000170390 | NUI |
| D00176 | KEGG_DRUG |
| 53935-32-3 | SECONDARY_CAS_RN |
| 4018469 | VANDF |
| C0040162 | UMLSCUI |
| CHEBI:35940 | CHEBI |
| CHEMBL1472 | ChEMBL_ID |
| DB09421 | DRUGBANK_ID |
| 638678 | PUBCHEM_CID |
| 3335 | INN_ID |
| 5Y5F15120W | UNII |
| 10580 | RXNORM |
| 5380 | MMSL |
| d03679 | MMSL |
| 002111 | NDDF |
| 10534002 | SNOMEDCT_US |
| 412495007 | SNOMEDCT_US |
| 412496008 | SNOMEDCT_US |
| 73805002 | SNOMEDCT_US |
| 2139 | IUPHAR_LIGAND_ID |
| 5Y5F15120W | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Thyrotropin Releasing HormoneTRH | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51808-209 | SOLUTION | 500 ug | INTRAVENOUS | Unapproved drug other | 9 sections |