progesterone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 2279 57-83-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • progesterone
  • gestone
  • gestormone
  • glanducorpin
  • lugesteron
  • lugesterone
  • progestan
  • progeston
  • progestone
  • progestron
  • progesterol
  • syngesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
  • Molecular weight: 314.47
  • Formula: C21H30O2
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -4.76
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
5 mg P
0.20 g R
90 mg V

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 21.20 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 4, 1976 FDA ALZA
Sept. 27, 2021 PMDA FUJI PHARMA CO., LTD.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 960.36 12.65 246 28954 3768 63456054
Temperature regulation disorder 501.54 12.65 163 29037 5969 63453853
Food allergy 413.21 12.65 166 29034 11235 63448587
Coeliac disease 391.34 12.65 165 29035 12632 63447190
Exposure during pregnancy 319.38 12.65 375 28825 155172 63304650
Immunodeficiency 318.99 12.65 165 29035 20089 63439733
Bursitis 245.46 12.65 173 29027 36868 63422954
Rash erythematous 235.14 12.65 178 29022 42332 63417490
Premature labour 208.82 12.65 106 29094 12398 63447424
Foetal exposure during pregnancy 204.18 12.65 146 29054 31816 63428006
Abortion spontaneous 199.92 12.65 169 29031 47026 63412796
Maternal exposure during pregnancy 197.89 12.65 359 28841 219703 63240119
Fluid retention 190.13 12.65 182 29018 59504 63400318
Premature delivery 176.78 12.65 131 29069 30150 63429672
Hyperhidrosis 169.94 12.65 228 28972 107608 63352214
Upper respiratory tract infection 156.88 12.65 191 29009 81856 63377966
Product adhesion issue 154.81 12.65 64 29136 4655 63455167
Meningioma 118.41 12.65 50 29150 3835 63455987
Gestational diabetes 114.04 12.65 62 29138 8334 63451488
Premature baby 104.06 12.65 82 29118 20653 63439169
Asthma 101.84 12.65 198 29002 127363 63332459
Erythema 101.36 12.65 239 28961 175512 63284310
Foetal death 101.10 12.65 63 29137 10917 63448905
Death 97.40 12.65 26 29174 374355 63085467
Vaginal haemorrhage 95.49 12.65 88 29112 27399 63432423
Headache 91.43 12.65 549 28651 632692 62827130
Postmenopausal haemorrhage 83.88 12.65 33 29167 2109 63457713
Pregnancy 80.70 12.65 92 29108 36744 63423078
Autoimmune dermatitis 78.48 12.65 17 29183 118 63459704
Oligohydramnios 78.19 12.65 44 29156 6322 63453500
Premature rupture of membranes 76.62 12.65 40 29160 4953 63454869
Hot flush 75.69 12.65 105 29095 51054 63408768
Butterfly rash 75.40 12.65 29 29171 1744 63458078
Maternal exposure before pregnancy 73.49 12.65 45 29155 7558 63452264
Systemic lupus erythematosus 70.89 12.65 7 29193 208911 63250911
Toxicity to various agents 70.56 12.65 14 29186 247236 63212586
Pre-eclampsia 68.33 12.65 46 29154 9087 63450735
Glossodynia 66.28 12.65 4 29196 178872 63280950
Off label use 66.03 12.65 532 28668 673930 62785892
Constipation 64.89 12.65 239 28961 224704 63235118
Placenta accreta 64.69 12.65 16 29184 210 63459612
Congenital absence of vertebra 63.60 12.65 12 29188 36 63459786
Synovitis 61.52 12.65 7 29193 186911 63272911
Wound 59.45 12.65 4 29196 163259 63296563
Back pain 58.88 12.65 259 28941 263886 63195936
Drug hypersensitivity 58.53 12.65 290 28910 310397 63149425
Congenital vesicoureteric reflux 55.87 12.65 10 29190 20 63459802
Ectopic pregnancy 55.59 12.65 26 29174 2541 63457281
Atrial septal defect 54.45 12.65 36 29164 6902 63452920
Acute kidney injury 53.77 12.65 27 29173 263388 63196434
Pneumonia 52.17 12.65 81 29119 456686 63003136
Normal newborn 50.71 12.65 37 29163 8304 63451518
Arthropathy 49.54 12.65 23 29177 234769 63225053
Vulvovaginal discomfort 48.16 12.65 23 29177 2355 63457467
Haemorrhage in pregnancy 46.38 12.65 21 29179 1904 63457918
Abortion threatened 45.92 12.65 15 29185 557 63459265
Preterm premature rupture of membranes 45.84 12.65 19 29181 1390 63458432
Ovarian enlargement 43.92 12.65 14 29186 480 63459342
Subdural hygroma 43.56 12.65 12 29188 245 63459577
Periorbital oedema 43.41 12.65 29 29171 5655 63454167
Pericarditis 43.10 12.65 5 29195 131574 63328248
Progesterone decreased 42.05 12.65 10 29190 110 63459712
Prescribed overdose 41.65 12.65 64 29136 34089 63425733
Small for dates baby 40.92 12.65 24 29176 3727 63456095
Hepatic enzyme increased 39.57 12.65 191 29009 202137 63257685
Intermenstrual bleeding 39.02 12.65 31 29169 7895 63451927
Hormone level abnormal 38.41 12.65 20 29180 2463 63457359
Completed suicide 38.03 12.65 10 29190 145663 63314159
Gastroschisis 37.66 12.65 12 29188 411 63459411
Adnexal torsion 36.83 12.65 12 29188 442 63459380
Abdominal discomfort 36.50 12.65 57 29143 320828 63138994
Foetal growth restriction 36.02 12.65 29 29171 7524 63452298
Blister 35.67 12.65 8 29192 129806 63330016
Head discomfort 35.46 12.65 37 29163 13378 63446444
Human herpesvirus 6 infection 35.13 12.65 20 29180 2937 63456885
Ventricular septal defect 35.04 12.65 23 29177 4355 63455467
Periodic limb movement disorder 34.62 12.65 10 29190 244 63459578
Single umbilical artery 34.31 12.65 10 29190 252 63459570
Uterine haemorrhage 34.23 12.65 22 29178 4019 63455803
Hypersensitivity 34.17 12.65 241 28959 292444 63167378
Blood oestrogen decreased 34.09 12.65 10 29190 258 63459564
Photosensitivity reaction 33.77 12.65 38 29162 14956 63444866
HELLP syndrome 33.70 12.65 14 29186 1030 63458792
Abortion missed 32.92 12.65 16 29184 1703 63458119
Rheumatoid arthritis 32.60 12.65 214 28986 253605 63206217
Breast hyperplasia 32.59 12.65 10 29190 302 63459520
Endometrial stromal sarcoma 32.06 12.65 6 29194 17 63459805
Ovarian haemorrhage 31.80 12.65 10 29190 328 63459494
Suicidal behaviour 31.76 12.65 18 29182 2621 63457201
Product use issue 31.46 12.65 191 29009 220329 63239493
Caesarean section 31.45 12.65 39 29161 16993 63442829
Neutropenia 31.33 12.65 21 29179 174984 63284838
Ophthalmic vein thrombosis 31.26 12.65 9 29191 217 63459605
Swelling 31.22 12.65 49 29151 275329 63184493
Ascites 30.97 12.65 62 29138 40666 63419156
Confusional state 30.86 12.65 38 29162 236342 63223480
Product odour abnormal 30.79 12.65 14 29186 1282 63458540
Sepsis 30.76 12.65 16 29184 153107 63306715
General physical health deterioration 30.02 12.65 29 29171 201373 63258449
Psoriasis 29.88 12.65 98 29102 86859 63372963
Therapeutic product effect decreased 29.76 12.65 27 29173 193160 63266662
Retroplacental haematoma 29.39 12.65 8 29192 156 63459666
Decreased appetite 29.10 12.65 44 29156 251008 63208814
Twin pregnancy 28.91 12.65 13 29187 1160 63458662
Breast tenderness 28.20 12.65 16 29184 2334 63457488
Anaemia 28.08 12.65 58 29142 293372 63166450
Tinnitus 28.01 12.65 55 29145 35573 63424249
Product quality issue 27.76 12.65 55 29145 35810 63424012
Retained placenta or membranes 27.50 12.65 9 29191 336 63459486
Ovarian cyst 27.05 12.65 35 29165 15910 63443912
Cardiac arrest 26.88 12.65 5 29195 92540 63367282
Cyanosis neonatal 26.00 12.65 9 29191 400 63459422
Decidual cast 24.50 12.65 4 29196 3 63459819
Peripheral swelling 24.24 12.65 54 29146 265888 63193934
Patent ductus arteriosus 23.92 12.65 18 29182 4232 63455590
Hippocampal sclerosis 23.58 12.65 6 29194 89 63459733
Pelvic infection 22.83 12.65 8 29192 369 63459453
Application site pruritus 22.71 12.65 17 29183 3967 63455855
Talipes 22.67 12.65 12 29188 1528 63458294
Anxiety 22.43 12.65 174 29026 217367 63242455
Complication of pregnancy 22.35 12.65 9 29191 611 63459211
Menopausal symptoms 22.35 12.65 14 29186 2447 63457375
Folliculitis 22.22 12.65 3 29197 70314 63389508
Lower respiratory tract infection 22.21 12.65 17 29183 132290 63327532
Hypotonia neonatal 22.08 12.65 11 29189 1235 63458587
Vaginal discharge 21.90 12.65 24 29176 9174 63450648
Application site erythema 21.87 12.65 18 29182 4817 63455005
Product use in unapproved indication 21.77 12.65 149 29051 178931 63280891
Subchorionic haematoma 21.67 12.65 6 29194 125 63459697
Vomiting 21.48 12.65 160 29040 559457 62900365
Drug abuse 20.88 12.65 4 29196 72514 63387308
Mediastinal effusion 20.86 12.65 5 29195 57 63459765
Malignant neoplasm progression 20.75 12.65 6 29194 82115 63377707
Stomatitis 20.63 12.65 20 29180 138705 63321117
Nerve compression 20.41 12.65 23 29177 9064 63450758
Congenital umbilical hernia 20.33 12.65 7 29193 306 63459516
Carnitine deficiency 20.19 12.65 6 29194 162 63459660
Cardiac failure 19.94 12.65 8 29192 89134 63370688
Hypotension 19.79 12.65 62 29138 272542 63187280
Infection 19.70 12.65 48 29152 229125 63230697
Application site rash 19.69 12.65 13 29187 2485 63457337
Cholestasis of pregnancy 19.33 12.65 10 29190 1215 63458607
Wheezing 19.18 12.65 10 29190 95585 63364237
Hydrops foetalis 19.11 12.65 8 29192 600 63459222
Irritable bowel syndrome 19.10 12.65 7 29193 82405 63377417
Disease progression 19.08 12.65 17 29183 122741 63337081
Tubo-ovarian abscess 19.06 12.65 7 29193 370 63459452
Ovarian abscess 18.93 12.65 6 29194 202 63459620
Renal failure 18.64 12.65 16 29184 117636 63342186
Oestradiol increased 18.64 12.65 5 29195 92 63459730
Gastrointestinal haemorrhage 18.63 12.65 7 29193 81169 63378653
Temporal lobe epilepsy 18.47 12.65 7 29193 404 63459418
Haemoglobin decreased 18.34 12.65 24 29176 145461 63314361
Eosinophilic pneumonia acute 18.23 12.65 7 29193 419 63459403
Renal impairment 18.09 12.65 9 29191 88346 63371476
Cardiac failure congestive 18.06 12.65 10 29190 92423 63367399
Muscle injury 18.00 12.65 4 29196 65341 63394481
Hypogonadism 17.89 12.65 5 29195 108 63459714
Fallopian tube disorder 17.74 12.65 7 29193 451 63459371
Febrile neutropenia 17.70 12.65 17 29183 118432 63341390
Low birth weight baby 17.67 12.65 19 29181 7110 63452712
Dyspnoea 17.66 12.65 207 28993 661106 62798716
Postpartum haemorrhage 17.31 12.65 11 29189 1970 63457852
Therapeutic response unexpected 17.29 12.65 31 29169 18728 63441094
Turner's syndrome 17.12 12.65 5 29195 127 63459695
Abdominal pain lower 17.07 12.65 37 29163 25641 63434181
Selective eating disorder 16.86 12.65 11 29189 2061 63457761
Diarrhoea 16.84 12.65 230 28970 715136 62744686
Breast enlargement 16.62 12.65 10 29190 1626 63458196
Feeling abnormal 16.59 12.65 121 29079 148271 63311551
Neonatal asphyxia 16.45 12.65 6 29194 311 63459511
Ultrasound liver abnormal 16.35 12.65 4 29196 50 63459772
Mobility decreased 16.30 12.65 19 29181 121140 63338682
Endometrial hyperplasia 16.28 12.65 8 29192 872 63458950
Enlarged clitoris 16.23 12.65 5 29195 153 63459669
Biochemical pregnancy 16.16 12.65 3 29197 8 63459814
COVID-19 16.13 12.65 98 29102 113005 63346817
Application site irritation 16.00 12.65 10 29190 1740 63458082
Overdose 15.96 12.65 99 29101 114979 63344843
Palatal polyp 15.90 12.65 3 29197 9 63459813
Platelet count decreased 15.85 12.65 18 29182 116104 63343718
Drug exposure before pregnancy 15.83 12.65 8 29192 926 63458896
Opisthotonus 15.77 12.65 6 29194 350 63459472
Primary hypogonadism 15.62 12.65 5 29195 174 63459648
Premature separation of placenta 15.44 12.65 10 29190 1851 63457971
Injection site pain 15.17 12.65 107 29093 129693 63330129
Chronic obstructive pulmonary disease 15.08 12.65 5 29195 62681 63397141
Incorrect dose administered 15.02 12.65 61 29139 59907 63399915
Impaired healing 15.00 12.65 15 29185 102527 63357295
Fall 14.63 12.65 113 29087 392221 63067601
Product taste abnormal 14.48 12.65 10 29190 2057 63457765
Retinal vein occlusion 14.16 12.65 10 29190 2133 63457689
Heterotopic pregnancy 14.09 12.65 3 29197 19 63459803
Arterial intramural haematoma 14.09 12.65 3 29197 19 63459803
Cardio-respiratory arrest 14.05 12.65 5 29195 59954 63399868
Binge eating 14.01 12.65 6 29194 476 63459346
Pulmonary oedema 13.88 12.65 4 29196 54869 63404953
Anti-Muellerian hormone level decreased 13.75 12.65 4 29196 100 63459722
Application site urticaria 13.73 12.65 5 29195 258 63459564
Chorioretinopathy 13.67 12.65 7 29193 832 63458990
Respiratory disorder neonatal 13.67 12.65 8 29192 1237 63458585
Endometrial cancer stage I 13.66 12.65 5 29195 262 63459560
Product physical issue 13.64 12.65 14 29186 4966 63454856
Dehydration 13.60 12.65 38 29162 173316 63286506
Foetal hypokinesia 13.57 12.65 6 29194 514 63459308
Amniotic cavity infection 13.56 12.65 8 29192 1255 63458567
Blood oestrogen increased 13.46 12.65 4 29196 108 63459714
Keratoconus 13.37 12.65 3 29197 25 63459797
Lung disorder 13.27 12.65 6 29194 62255 63397567
Pancytopenia 13.26 12.65 15 29185 96918 63362904
Feeling hot 13.23 12.65 52 29148 50302 63409520
Oesophageal atresia 13.20 12.65 6 29194 549 63459273
Abortion early 13.16 12.65 3 29197 27 63459795
Drug intolerance 12.91 12.65 86 29114 308575 63151247
Pyogenic granuloma 12.87 12.65 5 29195 309 63459513
Liver tenderness 12.81 12.65 4 29196 128 63459694
Bradycardia 12.81 12.65 9 29191 73218 63386604
Abortion 12.80 12.65 10 29190 2486 63457336
Live birth 12.77 12.65 33 29167 25597 63434225
Malaise 12.76 12.65 126 29074 415828 63043994
Musculoskeletal stiffness 12.68 12.65 43 29157 184575 63275247

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 701.50 85.14 173 933 37928 34917897
Premature baby 362.17 85.14 90 1016 19543 34936282
Atrial septal defect 151.22 85.14 37 1069 7355 34948470
Low birth weight baby 133.79 85.14 34 1072 7871 34947954
Hypospadias 107.59 85.14 24 1082 3177 34952648
Congenital hydronephrosis 101.95 85.14 18 1088 715 34955110
Human herpesvirus 6 infection 88.86 85.14 19 1087 2062 34953763

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian hyperstimulation syndrome 1015.01 14.18 228 21815 3343 79719002
Temperature regulation disorder 545.18 14.18 153 21890 5700 79716645
Food allergy 464.34 14.18 156 21887 10668 79711677
Coeliac disease 453.15 14.18 155 21888 11196 79711149
Immunodeficiency 361.61 14.18 157 21886 21611 79700734
Exposure during pregnancy 322.40 14.18 248 21795 100884 79621461
Bursitis 303.91 14.18 163 21880 35681 79686664
Maternal exposure during pregnancy 257.65 14.18 248 21795 136290 79586055
Rash erythematous 246.22 14.18 169 21874 57600 79664745
Fluid retention 224.09 14.18 172 21871 69637 79652708
Premature delivery 188.49 14.18 103 21940 23364 79698981
Upper respiratory tract infection 178.28 14.18 169 21874 90999 79631346
Hyperhidrosis 155.17 14.18 200 21843 151292 79571053
Abortion spontaneous 153.99 14.18 98 21945 29409 79692936
Premature labour 144.13 14.18 62 21981 8328 79714017
Asthma 139.34 14.18 179 21864 134916 79587429
Headache 130.20 14.18 436 21607 653336 79069009
Gestational diabetes 123.08 14.18 51 21992 6242 79716103
Erythema 110.60 14.18 211 21832 223079 79499266
Meningioma 108.97 14.18 42 22001 4256 79718089
Foetal death 101.73 14.18 48 21995 7996 79714349
Rheumatoid arthritis 100.77 14.18 195 21848 208275 79514070
Hepatic enzyme increased 98.44 14.18 179 21864 182431 79539914
Death 97.95 14.18 19 22024 566495 79155850
Butterfly rash 91.11 14.18 29 22014 1667 79720678
Back pain 90.10 14.18 234 21809 303946 79418399
Drug hypersensitivity 88.58 14.18 230 21813 298686 79423659
Premature rupture of membranes 86.47 14.18 35 22008 4034 79718311
Pre-eclampsia 85.94 14.18 41 22002 7000 79715345
Acute kidney injury 82.55 14.18 21 22022 519383 79202962
Vaginal haemorrhage 81.65 14.18 59 21984 21758 79700587
Maternal exposure before pregnancy 80.68 14.18 34 22009 4339 79718006
Autoimmune dermatitis 77.82 14.18 16 22027 149 79722196
Toxicity to various agents 77.49 14.18 12 22031 421528 79300817
Constipation 75.97 14.18 210 21833 282840 79439505
Hypersensitivity 73.81 14.18 198 21845 262041 79460304
Placenta accreta 73.74 14.18 16 22027 197 79722148
Normal newborn 70.86 14.18 36 22007 7036 79715309
Product adhesion issue 67.04 14.18 26 22017 2678 79719667
Haemorrhage in pregnancy 59.10 14.18 20 22023 1394 79720951
Keratoconus 57.86 14.18 12 22031 117 79722228
Ovarian enlargement 55.05 14.18 14 22029 354 79721991
Prescribed overdose 51.81 14.18 58 21985 37825 79684520
Abortion threatened 48.31 14.18 13 22030 412 79721933
Off label use 47.51 14.18 419 21624 906796 78815549
Pneumonia 46.69 14.18 69 21974 660177 79062168
Periorbital oedema 46.55 14.18 29 22014 8373 79713972
Hot flush 46.27 14.18 66 21977 54811 79667534
Uterine haemorrhage 45.13 14.18 20 22023 2883 79719462
Head discomfort 44.87 14.18 35 22008 14467 79707878
HELLP syndrome 44.20 14.18 14 22029 792 79721553
Ectopic pregnancy 44.07 14.18 17 22026 1726 79720619
Contraindicated product administered 41.32 14.18 116 21927 157422 79564923
Product use issue 40.64 14.18 139 21904 209683 79512662
Fatigue 40.48 14.18 413 21630 929314 78793031
Vulvovaginal discomfort 39.71 14.18 16 22027 1822 79720523
Breast hyperplasia 39.23 14.18 9 22034 145 79722200
Completed suicide 38.85 14.18 10 22033 245757 79476588
Postmenopausal haemorrhage 38.75 14.18 15 22028 1537 79720808
Neutropenia 37.96 14.18 16 22027 287694 79434651
Pain 37.76 14.18 327 21716 703475 79018870
Ovarian haemorrhage 37.49 14.18 10 22033 306 79722039
Photosensitivity reaction 37.17 14.18 37 22006 21090 79701255
Cardiac arrest 36.33 14.18 3 22040 172093 79550252
Adnexal torsion 35.59 14.18 10 22033 373 79721972
Ophthalmic vein thrombosis 35.26 14.18 9 22034 231 79722114
Pregnancy 34.82 14.18 40 22003 26811 79695534
Twin pregnancy 34.82 14.18 12 22031 884 79721461
Psoriasis 34.05 14.18 76 21967 89511 79632834
Caesarean section 33.99 14.18 28 22015 12507 79709838
Suicidal behaviour 33.91 14.18 17 22026 3230 79719115
Drug abuse 33.89 14.18 3 22040 162688 79559657
Intermenstrual bleeding 31.82 14.18 20 22023 5864 79716481
Sepsis 30.99 14.18 18 22025 269410 79452935
Anaemia 30.92 14.18 47 21996 444968 79277377
Synovitis 30.81 14.18 3 22040 150731 79571614
Preterm premature rupture of membranes 30.71 14.18 12 22031 1261 79721084
Retroplacental haematoma 29.94 14.18 7 22036 123 79722222
Hypotension 29.17 14.18 48 21995 440269 79282076
Confusional state 29.12 14.18 27 22016 317970 79404375
Endometrial stromal sarcoma 29.04 14.18 5 22038 15 79722330
Menopausal symptoms 28.84 14.18 13 22030 1950 79720395
Hormone level abnormal 28.59 14.18 13 22030 1989 79720356
Oligohydramnios 27.45 14.18 15 22028 3397 79718948
Tinnitus 27.13 14.18 46 21997 44287 79678058
Renal failure 26.78 14.18 11 22032 200957 79521388
Pelvic infection 26.69 14.18 8 22035 376 79721969
Ovarian abscess 26.68 14.18 6 22037 88 79722257
Product odour abnormal 26.64 14.18 11 22032 1333 79721012
Decidual cast 26.54 14.18 4 22039 3 79722342
Decreased appetite 25.93 14.18 34 22009 342384 79379961
Oestradiol increased 25.91 14.18 6 22037 101 79722244
Febrile neutropenia 25.76 14.18 16 22027 230983 79491362
Ovarian cyst 25.73 14.18 24 22019 12631 79709714
Progesterone decreased 25.34 14.18 5 22038 37 79722308
Foetal growth restriction 24.83 14.18 12 22031 2107 79720238
Foetal exposure during pregnancy 24.78 14.18 17 22026 5773 79716572
Retained placenta or membranes 24.71 14.18 7 22036 269 79722076
Ascites 24.24 14.18 60 21983 75502 79646843
Abortion missed 23.75 14.18 10 22033 1273 79721072
Blood oestrogen decreased 23.62 14.18 6 22037 151 79722194
Gastrointestinal haemorrhage 23.35 14.18 6 22037 147713 79574632
Mediastinal effusion 23.24 14.18 5 22038 59 79722286
Tubo-ovarian abscess 23.21 14.18 7 22036 336 79722009
Cardiac failure 23.16 14.18 7 22036 154835 79567510
Cholestasis of pregnancy 22.69 14.18 9 22034 984 79721361
Complication of pregnancy 22.48 14.18 7 22036 374 79721971
Bradycardia 22.42 14.18 5 22038 135552 79586793
Swelling face 22.26 14.18 56 21987 71156 79651189
General physical health deterioration 22.22 14.18 26 22017 275212 79447133
Abdominal pain lower 22.18 14.18 35 22008 31747 79690598
Renal impairment 22.08 14.18 8 22035 157775 79564570
Hypotonia neonatal 21.94 14.18 5 22038 78 79722267
Fallopian tube disorder 21.89 14.18 7 22036 408 79721937
Nerve compression 21.69 14.18 19 22024 9220 79713125
Postpartum haemorrhage 21.66 14.18 10 22033 1585 79720760
Porphyria non-acute 21.44 14.18 8 22035 741 79721604
Systemic lupus erythematosus 21.01 14.18 4 22039 121145 79601200
Amniotic cavity infection 20.67 14.18 8 22035 819 79721526
Malignant neoplasm progression 20.60 14.18 6 22037 135984 79586361
Carnitine deficiency 20.16 14.18 6 22037 275 79722070
Injection site pain 20.06 14.18 80 21963 129758 79592587
Hirsutism 19.82 14.18 9 22034 1373 79720972
Nephrocalcinosis 19.10 14.18 9 22034 1493 79720852
Breast enlargement 18.62 14.18 9 22034 1580 79720765
Platelet count decreased 18.44 14.18 16 22027 194648 79527697
Breast tenderness 18.32 14.18 10 22033 2258 79720087
Placental insufficiency 18.31 14.18 8 22035 1115 79721230
Cardio-respiratory arrest 17.95 14.18 4 22039 108506 79613839
Primary hypogonadism 17.91 14.18 5 22038 182 79722163
Haemoglobin decreased 17.91 14.18 21 22022 222098 79500247
Feeling hot 17.66 14.18 46 21997 59688 79662657
COVID-19 17.46 14.18 88 21955 157586 79564759
Congenital hydronephrosis 17.43 14.18 3 22040 9 79722336
Cardiac failure congestive 17.10 14.18 9 22034 142393 79579952
Respiratory failure 16.97 14.18 15 22028 180896 79541449
Blister 16.81 14.18 6 22037 119470 79602875
Glossodynia 16.72 14.18 4 22039 103333 79619012
Binge eating 16.66 14.18 6 22037 503 79721842
Arthropathy 16.24 14.18 15 22028 177096 79545249
Ovarian cyst ruptured 16.13 14.18 7 22036 959 79721386
Failed induction of labour 15.83 14.18 5 22038 280 79722065
Anti-Muellerian hormone level decreased 15.77 14.18 4 22039 100 79722245
Heterotopic pregnancy 15.61 14.18 3 22040 19 79722326
Product taste abnormal 15.60 14.18 9 22034 2262 79720083
Dehydration 15.55 14.18 28 22015 248159 79474186
Endometrial hyperplasia 15.36 14.18 6 22037 630 79721715
Subchorionic haematoma 15.34 14.18 4 22039 112 79722233
Eosinophilic pneumonia acute 15.27 14.18 7 22036 1091 79721254
Pulmonary oedema 15.12 14.18 3 22040 88251 79634094
Heavy menstrual bleeding 15.10 14.18 19 22024 13992 79708353
Pericarditis 15.07 14.18 5 22038 104231 79618114
Depressed mood 15.02 14.18 38 22005 48442 79673903
Live birth 15 14.18 22 22021 18722 79703623
Genital haemorrhage 14.96 14.18 13 22030 6242 79716103
Vaginal discharge 14.88 14.18 14 22029 7449 79714896
Embedded device 14.81 14.18 10 22033 3309 79719036
Retinal vein occlusion 14.80 14.18 10 22033 3313 79719032
Erythema nodosum 14.67 14.18 12 22031 5305 79717040
Drug interaction 14.65 14.18 62 21981 415121 79307224
Hallucination 14.51 14.18 3 22040 85742 79636603
Chronic obstructive pulmonary disease 14.43 14.18 3 22040 85416 79636929
Product quality issue 14.26 14.18 30 22013 33910 79688435

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 46.81 37.71 15 363 45 89369
Congestive cardiomyopathy 40.41 37.71 14 364 57 89357

Pharmacologic Action:

SourceCodeDescription
ATC G03DA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnen (4) derivatives
ATC G03FA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
FDA CS M0017672 Progesterone
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D006728 Hormones
MeSH PA D011372 Progestins
FDA EPC N0000175601 Progesterone
CHEBI has role CHEBI:49323 contraceptive drugs
CHEBI has role CHEBI:59826 progestins
CHEBI has role CHEBI:70709 progesterone receptor agonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Dysfunctional uterine bleeding indication 19155002
Atrophic vaginitis indication 52441000
Secondary physiologic amenorrhea indication 86030004
Secondary malignant neoplasm of kidney indication 94360002
Postmenopausal osteoporosis indication 102447009
Endometriosis indication 129103003
Menopausal flushing indication 198436008
Endometrial carcinoma indication 254878006 DOID:2871
Infertility Secondary to Progesterone Deficiency indication
Amenorrhea Secondary to Ovarian Dysfunction indication
Prevention of Premature Labor indication
Endometrial Hyperplasia Prevention indication
Corpus Luteum Insufficiency Syndrome indication
Polycystic ovaries off-label use 69878008
Menorrhagia off-label use 386692008
Precocious puberty off-label use 400179000
Endogenous Estrogen Production Test off-label use
Female Hormonal Imbalance off-label use
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Impaired glucose tolerance contraindication 9414007
Hypercholesterolemia contraindication 13644009
Jaundice contraindication 18165001
Myocardial infarction contraindication 22298006 DOID:5844
Fibroadenosis of breast contraindication 23260002 DOID:10352
Diplopia contraindication 24982008
Retinal hemorrhage contraindication 28998008
Ectopic pregnancy contraindication 34801009 DOID:0060329
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Mild pre-eclampsia contraindication 41114007
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Thrombophlebitis contraindication 64156001 DOID:3875
Osteoporosis contraindication 64859006 DOID:11476
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Malignant neoplasm of liver contraindication 93870000 DOID:3571
Uterine leiomyoma contraindication 95315005 DOID:13223
Neoplasm of liver contraindication 126851005 DOID:3571
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Incomplete miscarriage contraindication 156072005
Bed-ridden contraindication 160685001
Mammography abnormal contraindication 168750009
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Chorea contraindication 271700006
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Osteopenia contraindication 312894000
Functional visual loss contraindication 313165001
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Optic disc edema contraindication 423341008 DOID:146
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Predisposition to Thrombosis contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cattle Estrus synchronization Indication
Cattle Induction of estrous cycles Indication
Cattle Synchronization of the return to estrus Indication
Cattle Advancement of first postpartum estrus Indication
Cattle Advancement of first pubertal estrus Indication
Cattle To increase rate of weight gain Indication
Cattle To improve feed efficiency Indication
Sheep Estrus induction Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Synovex C, Synovex S Zoetis Inc. 2
Component E-C with Tylan, Component E-S with Tylan Elanco US Inc. 3
EAZI-BREED CIDR Cattle Insert Zoetis Inc. 1
EAZI-BREED CIDR Sheep Insert Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1.78GM MILPROSA FERRING PHARMS INC N201110 April 29, 2020 DISCN SYSTEM VAGINAL 10548904 Feb. 3, 2029 METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN
1.78GM MILPROSA FERRING PHARMS INC N201110 April 29, 2020 DISCN SYSTEM VAGINAL 8580293 Jan. 21, 2030 METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 10206932 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 10675288 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 11033626 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 8846648 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 8846649 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 8933059 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 9114145 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 9114146 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
0.5MG;100MG BIJUVA MAYNE PHARMA N210132 Dec. 28, 2021 DISCN CAPSULE ORAL 9301920 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 10206932 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 10675288 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 10806740 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 11033626 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 11103513 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 8846648 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 8846649 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 9006222 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 9114145 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 9114146 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS
1MG;100MG BIJUVA MAYNE PHARMA N210132 Oct. 28, 2018 RX CAPSULE ORAL 9301920 Nov. 21, 2032 TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
1.78GM MILPROSA FERRING PHARMS INC N201110 April 29, 2020 DISCN SYSTEM VAGINAL April 29, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST ED50 9.88 WOMBAT-PK CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.59 CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.32 CHEMBL
Glucocorticoid receptor Nuclear hormone receptor Ki 7.52 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 11 WOMBAT-PK
Estrogen receptor Nuclear hormone receptor WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 8.07 CHEMBL
Corticosteroid-binding globulin Secreted Ki 7.38 CHEMBL
Sex hormone-binding globulin Secreted Kd 6.94 CHEMBL
Sterol O-acyltransferase 1 Enzyme IC50 4.77 CHEMBL
Fatty acid-binding protein, intestinal Cytosolic other Ki 4.70 CHEMBL
Cation channel sperm-associated protein 1 Ion channel ACTIVATOR EC50 8.11 IUPHAR
Cation channel sperm-associated protein 2 Ion channel ACTIVATOR EC50 8.11 IUPHAR
Cation channel sperm-associated protein 3 Ion channel ACTIVATOR EC50 8.11 IUPHAR
Cation channel sperm-associated protein 4 Ion channel ACTIVATOR EC50 8.11 IUPHAR
Short transient receptor potential channel 5 Ion channel BLOCKER IC50 5.30 IUPHAR
Sodium/nucleoside cotransporter 1 Transporter Ki 5.17 DRUG MATRIX
P2X purinoceptor 3 Ion channel IC50 5.80 CHEMBL
Androgen receptor Transcription factor IC50 5.81 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 7.57 CHEMBL
Progesterone receptor Transcription factor Ki 8.44 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Kd 6.62 CHEMBL
Androgen receptor Transcription factor IC50 7.43 CHEMBL
Progesterone receptor Transcription factor Ki 7.98 CHEMBL
C-8 sterol isomerase Enzyme Ki 5.35 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 6.18 CHEMBL
Steroid 5-alpha-reductase Enzyme IC50 5.80 CHEMBL
Estrogen receptor Transcription factor Kd 8.41 CHEMBL

External reference:

IDSource
4017453 VUID
N0000145841 NUI
D00066 KEGG_DRUG
4017453 VANDF
C0033308 UMLSCUI
CHEBI:17026 CHEBI
STR PDB_CHEM_ID
CHEMBL103 ChEMBL_ID
DB00396 DRUGBANK_ID
D011374 MESH_DESCRIPTOR_UI
C003549 MESH_SUPPLEMENTAL_RECORD_UI
5994 PUBCHEM_CID
2377 IUPHAR_LIGAND_ID
417 INN_ID
4G7DS2Q64Y UNII
8727 RXNORM
2110 MMSL
53089 MMSL
5365 MMSL
d00550 MMSL
001290 NDDF
16683002 SNOMEDCT_US
50318003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Crinone HUMAN PRESCRIPTION DRUG LABEL 1 0023-6150 GEL 45 mg VAGINAL NDA 24 sections
Crinone HUMAN PRESCRIPTION DRUG LABEL 1 0023-6150 GEL 45 mg VAGINAL NDA 24 sections
Crinone HUMAN PRESCRIPTION DRUG LABEL 1 0023-6151 GEL 90 mg VAGINAL NDA 24 sections
Crinone HUMAN PRESCRIPTION DRUG LABEL 1 0023-6151 GEL 90 mg VAGINAL NDA 24 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 0143-9725 INJECTION 50 mg INTRAMUSCULAR ANDA 13 sections
PROGESTERONE HUMAN PRESCRIPTION DRUG LABEL 1 0591-3128 INJECTION, SOLUTION 50 mg INTRAMUSCULAR NDA 13 sections
PROGESTERONE HUMAN PRESCRIPTION DRUG LABEL 1 0591-3128 INJECTION, SOLUTION 50 mg INTRAMUSCULAR NDA 13 sections
PROGESTERONE Human Prescription Drug Label 1 10888-7135 CAPSULE 100 mg ORAL ANDA 21 sections
PROGESTERONE Human Prescription Drug Label 1 10888-7136 CAPSULE 200 mg ORAL ANDA 21 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 16714-157 CAPSULE 100 mg ORAL ANDA 25 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 16714-158 CAPSULE 200 mg ORAL ANDA 25 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 17478-766 CAPSULE 100 mg ORAL ANDA 23 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 17478-767 CAPSULE 200 mg ORAL ANDA 23 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 43598-349 CAPSULE 100 mg ORAL ANDA 21 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 43598-349 CAPSULE 100 mg ORAL ANDA 21 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 43598-350 CAPSULE 200 mg ORAL ANDA 21 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 43598-350 CAPSULE 200 mg ORAL ANDA 21 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 50090-2527 CAPSULE 100 mg ORAL ANDA 23 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3240 CAPSULE 100 mg ORAL NDA 24 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 50090-4656 CAPSULE 100 mg ORAL ANDA 23 sections
Progesterone Human Prescription Drug Label 1 50090-5928 CAPSULE 100 mg ORAL ANDA 22 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 50090-6475 CAPSULE 100 mg ORAL ANDA 24 sections
Bijuva HUMAN PRESCRIPTION DRUG LABEL 2 50261-211 CAPSULE 100 mg ORAL NDA 33 sections
Bijuva HUMAN PRESCRIPTION DRUG LABEL 2 50261-211 CAPSULE 100 mg ORAL NDA 33 sections
Bijuva HUMAN PRESCRIPTION DRUG LABEL 2 50261-251 CAPSULE 100 mg ORAL NDA 33 sections
Progesterone HUMAN PRESCRIPTION DRUG LABEL 1 53002-1760 CAPSULE 200 mg ORAL ANDA 23 sections
Prometrium HUMAN PRESCRIPTION DRUG LABEL 1 54868-4230 CAPSULE 200 mg ORAL NDA 15 sections
Prometrium HUMAN PRESCRIPTION DRUG LABEL 1 54868-4250 CAPSULE 100 mg ORAL NDA 15 sections
Prochieve HUMAN PRESCRIPTION DRUG LABEL 1 55056-0406 GEL 45 mg VAGINAL NDA 24 sections
Crinone HUMAN PRESCRIPTION DRUG LABEL 1 55056-0806 GEL 90 mg VAGINAL NDA 24 sections