valproic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • epival
  • divalproex sodium
  • depakote
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 289.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1701.52 10.27 1669 110079 116205 50377171
Hyperammonaemia 1128.48 10.27 416 111332 4308 50489068
Hyperammonaemic encephalopathy 1077.05 10.27 325 111423 1674 50491702
Drug interaction 1028.99 10.27 1690 110058 197931 50295445
Status epilepticus 764.38 10.27 435 111313 12971 50480405
Foetal anticonvulsant syndrome 640.32 10.27 165 111583 407 50492969
Somnolence 601.21 10.27 1160 110588 153825 50339551
Epilepsy 566.67 10.27 431 111317 21136 50472240
Toxicity to various agents 509.42 10.27 1312 110436 211187 50282189
Aggression 502.59 10.27 398 111350 20718 50472658
Sopor 486.73 10.27 381 111367 19498 50473878
Arthralgia 460.66 10.27 197 111551 438505 50054871
Dysmorphism 459.78 10.27 175 111573 1992 50491384
Pain 458.36 10.27 366 111382 578537 49914839
Psychotic disorder 443.25 10.27 375 111373 21437 50471939
Ammonia increased 431.00 10.27 203 111545 4038 50489338
Intentional overdose 426.59 10.27 604 111144 61900 50431476
Foetal exposure during pregnancy 426.52 10.27 405 111343 26954 50466422
Generalised tonic-clonic seizure 422.64 10.27 396 111352 25914 50467462
Multiple-drug resistance 394.33 10.27 177 111571 3137 50490239
Extrapyramidal disorder 390.58 10.27 271 111477 11499 50481877
Coma 387.17 10.27 549 111199 56330 50437046
Overdose 379.55 10.27 741 111007 98986 50394390
Drug level increased 368.55 10.27 320 111428 18948 50474428
Rheumatoid arthritis 356.83 10.27 23 111725 202527 50290849
Granulocytopenia 348.14 10.27 188 111560 5043 50488333
Tremor 347.55 10.27 777 110971 114126 50379250
Mania 347.44 10.27 245 111503 10671 50482705
Joint swelling 346.30 10.27 62 111686 245224 50248152
Speech disorder developmental 332.93 10.27 100 111648 505 50492871
Neuroleptic malignant syndrome 329.42 10.27 239 111509 10891 50482485
Intentional self-injury 326.19 10.27 324 111424 22788 50470588
Parkinsonism 320.36 10.27 215 111533 8632 50484744
Suicide attempt 318.15 10.27 476 111272 51256 50442120
Petit mal epilepsy 317.60 10.27 152 111596 3137 50490239
Fatigue 298.98 10.27 706 111042 706895 49786481
Sedation 288.57 10.27 347 111401 30263 50463113
Drug abuse 287.47 10.27 492 111256 59354 50434022
Infusion related reaction 282.31 10.27 25 111723 169532 50323844
Developmental delay 279.94 10.27 106 111642 1188 50492188
Abnormal behaviour 276.33 10.27 275 111473 19383 50473993
Dyspnoea 271.73 10.27 498 111250 547110 49946266
Agitation 271.17 10.27 450 111298 52934 50440442
Learning disorder 259.35 10.27 83 111665 535 50492841
Drug reaction with eosinophilia and systemic symptoms 257.81 10.27 316 111432 28108 50465268
Arthropathy 255.66 10.27 26 111722 157880 50335496
Abdominal discomfort 250.70 10.27 99 111649 231542 50261834
Depressed level of consciousness 250.67 10.27 428 111320 51525 50441851
Ataxia 243.74 10.27 219 111529 13567 50479809
Peripheral swelling 243.43 10.27 76 111672 205860 50287516
Cognitive disorder 237.70 10.27 382 111366 43741 50449635
Drug level decreased 232.31 10.27 157 111591 6376 50487000
Autism spectrum disorder 229.10 10.27 78 111670 625 50492751
Swelling 228.86 10.27 79 111669 200793 50292583
Contraindicated product administered 222.77 10.27 32 111716 148926 50344450
Diarrhoea 220.54 10.27 623 111125 587853 49905523
Schizoaffective disorder 213.16 10.27 102 111646 2104 50491272
Intellectual disability 212.24 10.27 76 111672 718 50492658
Electrocardiogram QT prolonged 208.80 10.27 395 111353 51491 50441885
Anticonvulsant drug level increased 207.43 10.27 87 111661 1297 50492079
Abortion spontaneous 205.28 10.27 347 111401 41425 50451951
Antipsychotic drug level increased 202.05 10.27 110 111638 2999 50490377
Hand deformity 201.42 10.27 4 111744 100195 50393181
Hypernatraemia 199.12 10.27 141 111607 6180 50487196
Salivary hypersecretion 196.09 10.27 142 111606 6449 50486927
Systemic lupus erythematosus 193.03 10.27 38 111710 140584 50352792
Glossodynia 187.10 10.27 19 111729 115550 50377826
Disturbance in attention 186.03 10.27 283 111465 30903 50462473
Sinusitis 179.40 10.27 76 111672 170482 50322894
Myoclonic epilepsy 179.38 10.27 71 111677 904 50492472
Sudden unexplained death in epilepsy 172.39 10.27 51 111697 242 50493134
Encephalopathy 172.25 10.27 285 111463 33426 50459950
Nasopharyngitis 170.27 10.27 108 111640 192819 50300557
Anticonvulsant drug level decreased 170.12 10.27 72 111676 1099 50492277
Pain in extremity 169.78 10.27 212 111536 272653 50220723
Anticonvulsant drug level above therapeutic 167.49 10.27 57 111691 456 50492920
Drug intolerance 165.83 10.27 144 111604 218960 50274416
Nausea 164.83 10.27 902 110846 704496 49788880
Schizophrenia 164.41 10.27 134 111614 7263 50486113
Hallucination, auditory 163.69 10.27 157 111591 10571 50482805
Disorientation 162.84 10.27 286 111462 35198 50458178
Hypothermia 161.33 10.27 164 111584 11852 50481524
Irritability 161.19 10.27 252 111496 28174 50465202
Psychomotor retardation 160.83 10.27 98 111650 3320 50490056
Altered state of consciousness 160.19 10.27 219 111529 21691 50471685
Hypotonia 155.32 10.27 135 111613 7999 50485377
Psychomotor skills impaired 153.80 10.27 80 111668 1984 50491392
Discomfort 153.62 10.27 27 111721 108353 50385023
Behaviour disorder 151.33 10.27 83 111665 2297 50491079
Hypersensitivity 149.22 10.27 153 111595 215008 50278368
Electroencephalogram abnormal 148.63 10.27 94 111654 3405 50489971
Treatment noncompliance 147.50 10.27 250 111498 29900 50463476
Stevens-Johnson syndrome 145.00 10.27 208 111540 21544 50471832
Learning disability 144.68 10.27 42 111706 184 50493192
Drug ineffective for unapproved indication 144.07 10.27 205 111543 21076 50472300
Delusion 143.26 10.27 145 111603 10424 50482952
Congenital nose malformation 142.61 10.27 44 111704 247 50493129
Drug withdrawal convulsions 141.29 10.27 66 111682 1287 50492089
Catatonia 138.15 10.27 92 111656 3644 50489732
Bipolar disorder 136.86 10.27 116 111632 6641 50486735
Partial seizures 136.11 10.27 101 111647 4764 50488612
Back pain 130.57 10.27 177 111571 219853 50273523
Cough 130.55 10.27 207 111541 241057 50252319
Educational problem 127.23 10.27 43 111705 336 50493040
Language disorder 126.67 10.27 67 111681 1721 50491655
Exposure during pregnancy 126.41 10.27 566 111182 120449 50372927
Paradoxical drug reaction 125.75 10.27 86 111662 3561 50489815
Suicidal ideation 125.06 10.27 335 111413 55050 50438326
Wound 124.97 10.27 39 111709 105755 50387621
Pruritus 123.80 10.27 277 111471 283291 50210085
Headache 122.26 10.27 640 111108 505895 49987481
Drug resistance 119.91 10.27 177 111571 18812 50474564
Dysarthria 119.74 10.27 259 111489 37144 50456232
Fanconi syndrome 117.34 10.27 55 111693 1081 50492295
Bradyphrenia 117.25 10.27 102 111646 6050 50487326
Meningomyelocele 117.14 10.27 45 111703 526 50492850
Psychomotor hyperactivity 114.17 10.27 121 111627 9180 50484196
Hypomania 111.64 10.27 87 111661 4418 50488958
Myoclonus 110.89 10.27 148 111600 14322 50479054
Product substitution issue 109.61 10.27 145 111603 13912 50479464
Therapeutic product effect decreased 109.59 10.27 84 111664 135966 50357410
Muscle rigidity 108.66 10.27 121 111627 9708 50483668
Completed suicide 108.41 10.27 576 111172 131313 50362063
Psychogenic seizure 108.36 10.27 58 111690 1527 50491849
Pneumonia aspiration 107.72 10.27 222 111526 30782 50462594
Injection site pain 106.64 10.27 56 111692 110968 50382408
Congenital hand malformation 104.86 10.27 35 111713 262 50493114
Anticonvulsant drug level below therapeutic 104.57 10.27 42 111706 557 50492819
Talipes 103.05 10.27 54 111694 1360 50492016
Congenital foot malformation 102.64 10.27 32 111716 187 50493189
Blood creatine phosphokinase increased 101.43 10.27 197 111551 26170 50467206
Tardive dyskinesia 100.74 10.27 101 111647 7178 50486198
Impaired healing 99.71 10.27 17 111731 69769 50423607
Febrile neutropenia 98.73 10.27 46 111702 97621 50395755
Respiratory depression 98.48 10.27 127 111621 11883 50481493
Thrombocytopenia 98.46 10.27 548 111200 127125 50366251
Mental disorder 97.98 10.27 175 111573 21816 50471560
Product residue present 97.75 10.27 74 111674 3598 50489778
Akathisia 97.39 10.27 105 111643 8124 50485252
Arthritis 97.13 10.27 35 111713 86686 50406690
Atonic seizures 96.87 10.27 40 111708 572 50492804
Hyperprolactinaemia 96.70 10.27 71 111677 3294 50490082
Rash 96.03 10.27 570 111178 436901 50056475
Carnitine deficiency 94.79 10.27 28 111720 132 50493244
Cerebral atrophy 93.21 10.27 79 111669 4522 50488854
Confusional state 93.18 10.27 716 111032 185212 50308164
Stupor 92.72 10.27 71 111677 3512 50489864
Nystagmus 91.75 10.27 85 111663 5476 50487900
Infection 90.12 10.27 152 111596 172802 50320574
Speech disorder 89.47 10.27 224 111524 35324 50458052
Rhabdomyolysis 89.04 10.27 237 111511 38790 50454586
Herpes zoster 87.42 10.27 24 111724 70762 50422614
Psychiatric symptom 85.54 10.27 75 111673 4495 50488881
Stomatitis 84.93 10.27 60 111688 101284 50392092
Injection site erythema 84.33 10.27 30 111718 74906 50418470
Low set ears 84.25 10.27 29 111719 241 50493135
Anaemia 82.95 10.27 283 111465 252173 50241203
Pericarditis 82.77 10.27 35 111713 78654 50414722
Hypertelorism 82.47 10.27 32 111716 385 50492991
Persecutory delusion 81.62 10.27 56 111692 2331 50491045
Dyskinesia 81.37 10.27 186 111562 27675 50465701
Delirium 81.20 10.27 226 111522 37966 50455410
Neuropathy peripheral 80.14 10.27 58 111690 96699 50396677
Abdominal pain upper 78.47 10.27 145 111603 159164 50334212
Arnold-Chiari malformation 77.40 10.27 32 111716 459 50492917
Focal dyscognitive seizures 77.06 10.27 57 111691 2675 50490701
Motor developmental delay 76.27 10.27 23 111725 118 50493258
Toxic epidermal necrolysis 76.10 10.27 153 111595 20839 50472537
Cardiac failure congestive 76.07 10.27 46 111702 84336 50409040
Loss of consciousness 75.88 10.27 441 111307 103912 50389464
Helicobacter infection 75.84 10.27 10 111738 49692 50443684
Propofol infusion syndrome 75.78 10.27 36 111712 730 50492646
Osteoarthritis 74.62 10.27 29 111719 68577 50424799
Folliculitis 73.56 10.27 3 111745 39222 50454154
Tonic convulsion 73.18 10.27 40 111708 1099 50492277
Strabismus 72.37 10.27 47 111701 1783 50491593
Chest pain 72.13 10.27 179 111569 176703 50316673
Ear malformation 72.10 10.27 24 111724 178 50493198
Intentional product use issue 72.09 10.27 40 111708 76878 50416498
Urticaria 72.06 10.27 109 111639 129452 50363924
Impulsive behaviour 71.68 10.27 43 111705 1415 50491961
Pleurothotonus 70.87 10.27 41 111707 1260 50492116
Microcephaly 70.63 10.27 35 111713 781 50492595
Mental impairment 69.97 10.27 108 111640 11936 50481440
Spina bifida 69.70 10.27 33 111715 664 50492712
Muscle injury 69.06 10.27 3 111745 37108 50456268
Affect lability 68.89 10.27 92 111656 8906 50484470
Musculoskeletal stiffness 68.68 10.27 111 111637 128370 50365006
Alopecia 68.65 10.27 293 111455 244754 50248622
Leukopenia 68.32 10.27 313 111435 67215 50426161
Product dose omission issue 68.17 10.27 195 111553 183643 50309733
Abortion induced 67.69 10.27 93 111655 9251 50484125
Lethargy 67.25 10.27 251 111497 49181 50444195
Enuresis 65.92 10.27 47 111701 2082 50491294
Gingival hypertrophy 65.88 10.27 40 111708 1346 50492030
Stillbirth 65.32 10.27 73 111675 5879 50487497
Death 65.07 10.27 436 111312 324943 50168433
Atrial septal defect 64.89 10.27 75 111673 6266 50487110
Neurodevelopmental disorder 64.72 10.27 14 111734 9 50493367
Oculogyric crisis 64.54 10.27 40 111708 1397 50491979
Congenital eyelid malformation 63.84 10.27 13 111735 3 50493373
Drug level below therapeutic 63.32 10.27 58 111690 3682 50489694
Infantile spasms 63.17 10.27 22 111726 190 50493186
Ileus paralytic 63.16 10.27 60 111688 3990 50489386
Hyperlactacidaemia 62.50 10.27 48 111700 2385 50490991
Weight increased 62.38 10.27 701 111047 201190 50292186
Blood prolactin increased 62.35 10.27 53 111695 3046 50490330
Dyspraxia 62.20 10.27 23 111725 240 50493136
Myocarditis 61.99 10.27 82 111666 7865 50485511
Metabolic encephalopathy 61.75 10.27 66 111682 5055 50488321
Hepatic function abnormal 61.38 10.27 185 111563 32496 50460880
Toxic encephalopathy 61.14 10.27 68 111680 5447 50487929
Dystonia 61.13 10.27 101 111647 11825 50481551
Blood pressure increased 60.52 10.27 127 111621 133005 50360371
Influenza 60.49 10.27 65 111683 89473 50403903
Attention deficit hyperactivity disorder 60.38 10.27 47 111701 2382 50490994
Malignant neoplasm progression 60.21 10.27 38 111710 68086 50425290
Acidosis hyperchloraemic 60.04 10.27 24 111724 314 50493062
Brain oedema 59.73 10.27 102 111646 12268 50481108
Restlessness 59.58 10.27 155 111593 25018 50468358
Resting tremor 59.48 10.27 30 111718 696 50492680
Dementia 58.47 10.27 117 111631 15880 50477496
Seizure cluster 58.40 10.27 21 111727 201 50493175
Gastrointestinal disorder 57.98 10.27 74 111674 94382 50398994
Psoriatic arthropathy 57.97 10.27 16 111732 47016 50446360
Knee arthroplasty 57.70 10.27 6 111742 35840 50457536
Paranoia 57.62 10.27 91 111657 10257 50483119
Dyspnoea exertional 56.81 10.27 21 111727 51212 50442164
Plasma cell myeloma 56.77 10.27 3 111745 31319 50462057
Poisoning 56.76 10.27 100 111648 12329 50481047
Communication disorder 56.75 10.27 44 111704 2217 50491159
Nasal congestion 56.60 10.27 21 111727 51099 50442277
Mitochondrial DNA mutation 55.97 10.27 21 111727 229 50493147
Flushing 55.71 10.27 40 111708 66975 50426401
Personal relationship issue 55.68 10.27 14 111734 30 50493346
Gastrointestinal haemorrhage 55.61 10.27 48 111700 73273 50420103
Suicidal behaviour 55.52 10.27 44 111704 2290 50491086
Neovascularisation 55.38 10.27 32 111716 981 50492395
Hypoaesthesia 54.86 10.27 125 111623 127132 50366244
Injection site reaction 54.65 10.27 21 111727 50011 50443365
Astigmatism 53.66 10.27 31 111717 950 50492426
Atrial fibrillation 53.34 10.27 89 111659 101656 50391720
Injection site pruritus 53.19 10.27 12 111736 40399 50452977
Grandiosity 53.15 10.27 21 111727 266 50493110
Productive cough 52.95 10.27 25 111723 52669 50440707
Fluid retention 52.50 10.27 23 111725 50626 50442750
Tonic clonic movements 51.96 10.27 33 111715 1204 50492172
Mental status changes 51.70 10.27 187 111561 36085 50457291
Anger 51.52 10.27 91 111657 11242 50482134
Encephalitis autoimmune 51.45 10.27 33 111715 1225 50492151
Myalgia 51.28 10.27 125 111623 124194 50369182
Intra-abdominal pressure increased 51.23 10.27 19 111729 200 50493176
Rhinorrhoea 51.03 10.27 25 111723 51558 50441818
Bipolar I disorder 50.46 10.27 35 111713 1483 50491893
Hypokinesia 50.34 10.27 94 111654 12123 50481253
Injection site swelling 50.03 10.27 15 111733 41758 50451618
Hepatic failure 49.95 10.27 171 111577 32112 50461264
Bone pain 49.67 10.27 21 111727 47208 50446168
Dyslexia 49.54 10.27 20 111728 269 50493107
Thrombosis 49.53 10.27 31 111717 55802 50437574
Hypertonia 49.32 10.27 52 111696 3921 50489455
Drug hypersensitivity 49.31 10.27 338 111410 250672 50242704
Irritable bowel syndrome 49.29 10.27 26 111722 51415 50441961
Hallucination 49.23 10.27 219 111529 46438 50446938
Musculoskeletal pain 49.19 10.27 52 111696 72125 50421251
Lower respiratory tract infection 48.33 10.27 85 111663 95116 50398260
Dysgraphia 48.30 10.27 43 111705 2630 50490746
Myopia 48.23 10.27 34 111714 1479 50491897
Wheezing 47.81 10.27 40 111708 62007 50431369
Lip disorder 47.50 10.27 31 111717 1186 50492190
Depressed mood 47.30 10.27 174 111574 33849 50459527
Cerebellar atrophy 47.27 10.27 25 111723 642 50492734
Lordosis 46.90 10.27 19 111729 258 50493118
Selective eating disorder 46.74 10.27 36 111712 1796 50491580
Psoriasis 46.70 10.27 50 111698 68950 50424426
Disease progression 46.52 10.27 88 111660 95778 50397598
Abdominal pain 46.44 10.27 318 111430 235910 50257466
Amenorrhoea 46.40 10.27 74 111674 8410 50484966
Differential white blood cell count abnormal 46.17 10.27 25 111723 674 50492702
Congenital scoliosis 45.89 10.27 10 111738 7 50493369
Angiofibroma 45.69 10.27 15 111733 106 50493270
Ventricular septal defect 45.10 10.27 50 111698 3991 50489385
Inflammation 44.71 10.27 36 111712 56876 50436500
Antipsychotic drug level decreased 44.38 10.27 17 111731 197 50493179
Bradykinesia 44.37 10.27 49 111699 3894 50489482
White blood cell count increased 44.36 10.27 198 111550 42042 50451334
Bronchitis 44.33 10.27 103 111645 104056 50389320
Clinodactyly 44.18 10.27 14 111734 87 50493289
Blood pressure systolic increased 43.80 10.27 12 111736 35437 50457939
Hepatic enzyme increased 43.71 10.27 156 111592 137224 50356152
Chest discomfort 43.35 10.27 87 111661 92635 50400741
Asthenia 43.31 10.27 473 111275 318569 50174807
Reflexes abnormal 43.06 10.27 22 111726 525 50492851
Hyponatraemia 43.05 10.27 361 111387 95778 50397598
Limbic encephalitis 42.98 10.27 17 111731 216 50493160
Coordination abnormal 42.92 10.27 85 111663 11449 50481927
Dysmetria 42.86 10.27 20 111728 389 50492987
Hallucinations, mixed 42.78 10.27 49 111699 4054 50489322
Hypertension 42.66 10.27 282 111466 210921 50282455
COVID-19 42.66 10.27 25 111723 46637 50446739
Chills 42.46 10.27 94 111654 96593 50396783
Contusion 42.29 10.27 118 111630 112065 50381311
Arachnodactyly 41.98 10.27 13 111735 74 50493302
Pneumatosis 41.86 10.27 20 111728 411 50492965
Drop attacks 41.85 10.27 23 111725 639 50492737
Aphasia 41.54 10.27 148 111600 28346 50465030
Tooth malformation 41.48 10.27 9 111739 6 50493370
C-reactive protein abnormal 41.47 10.27 6 111742 27803 50465573
Hot flush 41.33 10.27 23 111725 44146 50449230
Antipsychotic drug level above therapeutic 41.32 10.27 26 111722 933 50492443
Logorrhoea 41.23 10.27 37 111711 2287 50491089
Dry skin 41.13 10.27 22 111726 43169 50450207
Injection site bruising 40.88 10.27 15 111733 36753 50456623
Asterixis 40.86 10.27 28 111720 1163 50492213
Nephrogenic diabetes insipidus 40.78 10.27 25 111723 856 50492520
Refusal of treatment by patient 40.75 10.27 53 111695 5000 50488376
Pectus excavatum 40.72 10.27 13 111735 83 50493293
Craniosynostosis 40.61 10.27 15 111733 156 50493220
Pain in jaw 40.55 10.27 17 111731 38411 50454965
Neutropenia 40.45 10.27 502 111246 147463 50345913
Change in seizure presentation 40.19 10.27 17 111731 259 50493117
Interstitial lung disease 40.09 10.27 35 111713 53141 50440235
Eosinophilic pleural effusion 39.73 10.27 11 111737 39 50493337
Mood swings 39.58 10.27 100 111648 15854 50477522
Treatment failure 39.47 10.27 163 111585 137474 50355902
Metabolic acidosis 39.28 10.27 180 111568 38645 50454731
Psychotic behaviour 39.26 10.27 21 111727 552 50492824
Retinogram abnormal 39.21 10.27 14 111734 131 50493245
Hyperthermia 39.20 10.27 65 111683 7631 50485745
Oral mucosa erosion 39.05 10.27 26 111722 1029 50492347
Oropharyngeal pain 39 10.27 70 111678 77731 50415645
Plagiocephaly 38.89 10.27 11 111737 43 50493333
Acute hepatic failure 38.61 10.27 98 111650 15579 50477797
Carnitine decreased 38.40 10.27 8 111740 3 50493373
Cataract 38.31 10.27 29 111719 47271 50446105
Sluggishness 38.29 10.27 48 111700 4365 50489011
Hip arthroplasty 38.16 10.27 10 111738 30419 50462957
Malaise 38.11 10.27 517 111231 335015 50158361
Blood lactic acid increased 38.08 10.27 54 111694 5531 50487845
Oropharyngeal oedema 38.05 10.27 16 111732 240 50493136
Adjustment disorder with mixed anxiety and depressed mood 37.94 10.27 12 111736 74 50493302
Hypersexuality 37.90 10.27 19 111729 435 50492941
Necrosis ischaemic 37.82 10.27 23 111725 776 50492600
Tachycardia 37.68 10.27 361 111387 99402 50393974
Multiple congenital abnormalities 37.48 10.27 20 111728 523 50492853
Neutrophil count increased 37.35 10.27 91 111657 14104 50479272
Epistaxis 37.31 10.27 52 111696 63902 50429474
Hallucination, visual 37.10 10.27 100 111648 16482 50476894
Sinus rhythm 37.09 10.27 21 111727 619 50492757
Muscle spasms 37.06 10.27 147 111601 125406 50367970
Congenital anomaly 36.88 10.27 29 111719 1492 50491884
Affective disorder 36.67 10.27 51 111697 5130 50488246
Pneumonia 36.13 10.27 603 111145 377798 50115578
Apathy 36.12 10.27 62 111686 7486 50485890
Weight gain poor 36.11 10.27 22 111726 745 50492631
Psychotic symptom 35.79 10.27 26 111722 1186 50492190
Urinary incontinence 35.70 10.27 140 111608 28068 50465308
Haematochezia 35.57 10.27 22 111726 39860 50453516
Inappropriate antidiuretic hormone secretion 35.38 10.27 85 111663 13058 50480318
Hyperchloraemia 35.31 10.27 21 111727 680 50492696
Hypermetropia 35.06 10.27 18 111730 434 50492942
Congenital joint malformation 34.93 10.27 8 111740 9 50493367
Psychiatric decompensation 34.93 10.27 26 111722 1232 50492144
Delusion of grandeur 34.79 10.27 13 111735 140 50493236
Gene mutation 34.69 10.27 26 111722 1245 50492131
Camptodactyly congenital 34.48 10.27 8 111740 10 50493366
Platelet count decreased 34.42 10.27 357 111391 100369 50393007
Partial seizures with secondary generalisation 34.34 10.27 16 111732 310 50493066
Throat irritation 34.19 10.27 12 111736 30227 50463149
Bradycardia neonatal 34.12 10.27 22 111726 824 50492552
Balance disorder 33.71 10.27 269 111479 70321 50423055
Porphyria acute 33.45 10.27 18 111730 479 50492897
Poor sucking reflex 33.42 10.27 14 111734 208 50493168
Hyperglycinaemia 33.34 10.27 7 111741 3 50493373
Speech sound disorder 33.34 10.27 7 111741 3 50493373
Mydriasis 33.32 10.27 73 111675 10554 50482822
Unresponsive to stimuli 33.29 10.27 145 111603 30464 50462912
Gait disturbance 33.22 10.27 490 111258 149515 50343861
Galactorrhoea 33.11 10.27 41 111707 3682 50489694
General physical health deterioration 33.04 10.27 182 111566 142252 50351124
Metabolic disorder 32.97 10.27 49 111699 5237 50488139
Brief psychotic disorder, with postpartum onset 32.93 10.27 9 111739 30 50493346
Antipsychotic drug level below therapeutic 32.80 10.27 15 111733 278 50493098
Conjunctival hyperaemia 32.76 10.27 31 111717 2051 50491325
Posture abnormal 32.67 10.27 31 111717 2058 50491318
Anaphylactic reaction 32.49 10.27 43 111705 54012 50439364
Congenital hair disorder 32.43 10.27 10 111738 56 50493320
Neoplasm progression 32.24 10.27 12 111736 29145 50464231
High arched palate 32.21 10.27 11 111737 89 50493287
Nipple disorder 32.11 10.27 11 111737 90 50493286
Polydipsia 32.05 10.27 37 111711 3087 50490289
Fungal infection 32.03 10.27 13 111735 29952 50463424
Medication overuse headache 31.93 10.27 19 111729 616 50492760
Leukocytosis 31.83 10.27 116 111632 22463 50470913
Screaming 31.78 10.27 36 111712 2942 50490434
Device expulsion 31.64 10.27 12 111736 28810 50464566
Cystitis 31.62 10.27 31 111717 44533 50448843
Reading disorder 31.61 10.27 20 111728 725 50492651
Rabbit syndrome 31.54 10.27 15 111733 305 50493071
Cleft palate 31.53 10.27 22 111726 941 50492435
Diverticulitis 31.45 10.27 17 111731 33165 50460211
Drug level above therapeutic 31.43 10.27 41 111707 3879 50489497
Gaze palsy 31.43 10.27 25 111723 1308 50492068
Depressive symptom 31.33 10.27 37 111711 3163 50490213
Foetal death 31.31 10.27 61 111687 8119 50485257
Anticonvulsant drug level abnormal 31.27 10.27 9 111739 38 50493338
Glycosuria 31.25 10.27 23 111725 1071 50492305
Tic 31.24 10.27 24 111724 1193 50492183
Rash maculo-papular 31.14 10.27 129 111619 26512 50466864
Localised infection 30.79 10.27 9 111739 25476 50467900
Neck pain 30.76 10.27 49 111699 57018 50436358
Congenital flat feet 30.71 10.27 6 111742 0 50493376
Night sweats 30.67 10.27 18 111730 33556 50459820
Obesity 30.59 10.27 94 111654 16681 50476695
Breast hyperplasia 30.59 10.27 14 111734 260 50493116
Renal tubular acidosis 30.38 10.27 26 111722 1508 50491868
Palpitations 30.26 10.27 107 111641 94399 50398977
Angiomyolipoma 30.16 10.27 13 111735 208 50493168
Paraesthesia 29.92 10.27 150 111598 120093 50373283
Hypophosphataemic osteomalacia 29.88 10.27 12 111736 159 50493217
Myocardial infarction 29.72 10.27 99 111649 88928 50404448
Motor dysfunction 29.66 10.27 59 111689 7972 50485404
Respiratory disorder neonatal 29.66 10.27 21 111727 920 50492456
Skin ulcer 29.45 10.27 21 111727 35297 50458079
Ovarian granulosa-theca cell tumour 29.43 10.27 8 111740 26 50493350
Cardiac failure 29.38 10.27 79 111669 75961 50417415
Deafness congenital 29.24 10.27 7 111741 11 50493365
Blister 29.20 10.27 94 111654 85324 50408052
Automatism 28.95 10.27 9 111739 52 50493324
Polydactyly 28.90 10.27 14 111734 297 50493079
Fibromyalgia 28.89 10.27 34 111714 44944 50448432
Akinesia 28.86 10.27 25 111723 1474 50491902
Hypermobility syndrome 28.86 10.27 19 111729 738 50492638
Subileus 28.85 10.27 33 111715 2726 50490650
Prognathism 28.75 10.27 10 111738 86 50493290
Strabismus congenital 28.67 10.27 9 111739 54 50493322
Mucosal inflammation 28.39 10.27 28 111720 40114 50453262
Congenital oral malformation 28.36 10.27 12 111736 183 50493193
Drooling 28.08 10.27 36 111712 3348 50490028
Verbal abuse 28.06 10.27 10 111738 93 50493283
Congenital central nervous system anomaly 27.99 10.27 14 111734 319 50493057
Dyscalculia 27.87 10.27 10 111738 95 50493281
Hepatotoxicity 27.37 10.27 126 111622 27100 50466276
Accidental overdose 27.24 10.27 100 111648 19433 50473943
Pulmonary fibrosis 27.11 10.27 10 111738 24427 50468949
Cogwheel rigidity 27.09 10.27 26 111722 1751 50491625
Pancreatitis necrotising 26.93 10.27 23 111725 1330 50492046
Constipation 26.91 10.27 271 111477 185437 50307939
Weight decreased 26.88 10.27 336 111412 220909 50272467
Respiratory acidosis 26.88 10.27 48 111700 5980 50487396
Eye movement disorder 26.74 10.27 41 111707 4504 50488872
Blood gases abnormal 26.72 10.27 17 111731 622 50492754
Joint stiffness 26.64 10.27 17 111731 30291 50463085
Mood altered 26.56 10.27 75 111673 12698 50480678
Metastases to bone 26.56 10.27 4 111744 17991 50475385
Impaired reasoning 26.55 10.27 9 111739 71 50493305
Diplopia 26.35 10.27 98 111650 19162 50474214
Apraxia 26.23 10.27 24 111724 1521 50491855
Hirsutism 26.23 10.27 20 111728 983 50492393
Dacryostenosis congenital 26.08 10.27 6 111742 7 50493369
Monocytosis 25.84 10.27 13 111735 300 50493076
Echolalia 25.75 10.27 11 111737 172 50493204
Physical assault 25.73 10.27 19 111729 889 50492487
Heterophoria 25.69 10.27 7 111741 23 50493353
Disinhibition 25.35 10.27 18 111730 792 50492584
Withdrawal syndrome 25.33 10.27 91 111657 17499 50475877
Staring 25.23 10.27 23 111725 1451 50491925
Social avoidant behaviour 25.19 10.27 31 111717 2766 50490610
Product use issue 25.18 10.27 210 111538 149265 50344111
Osteonecrosis of jaw 25.01 10.27 21 111727 32505 50460871
Lactate pyruvate ratio increased 24.95 10.27 9 111739 87 50493289
Ultrasound ovary abnormal 24.95 10.27 9 111739 87 50493289
Ill-defined disorder 24.93 10.27 52 111696 54602 50438774
Cellulitis 24.83 10.27 77 111671 70721 50422655
Urinary tract infection 24.74 10.27 347 111401 223673 50269703
Pancreatitis 24.67 10.27 170 111578 42444 50450932
Ear disorder 24.58 10.27 33 111715 3210 50490166
Erythema 24.52 10.27 206 111542 146208 50347168
Palmar-plantar erythrodysaesthesia syndrome 24.46 10.27 7 111741 20091 50473285
Illogical thinking 24.31 10.27 8 111740 57 50493319
Hypervolaemia 24.26 10.27 13 111735 25486 50467890
Hypotonia neonatal 24.15 10.27 19 111729 978 50492398
Congenital cystic kidney disease 24.12 10.27 13 111735 347 50493029
Rotavirus infection 24.09 10.27 12 111736 271 50493105
Heart rate decreased 24.08 10.27 27 111721 36470 50456906
Hereditary ataxia 24.05 10.27 7 111741 31 50493345
Cerebellar syndrome 24.05 10.27 33 111715 3278 50490098
Pneumonitis 24.02 10.27 18 111730 29492 50463884
Loss of personal independence in daily activities 24.00 10.27 77 111671 69973 50423403
Precocious puberty 24.00 10.27 11 111737 205 50493171
Pulmonary hypertension 23.99 10.27 23 111725 33394 50459982
Vestibular migraine 23.95 10.27 11 111737 206 50493170
Eosinophilia 23.94 10.27 93 111655 18559 50474817
Depression 23.93 10.27 505 111243 164918 50328458
Obsessive-compulsive disorder 23.82 10.27 33 111715 3307 50490069
Feeling hot 23.75 10.27 31 111717 39171 50454205
Upper respiratory tract infection 23.59 10.27 71 111677 65827 50427549
Basal cell carcinoma 23.59 10.27 11 111737 23345 50470031
Executive dysfunction 23.55 10.27 10 111738 154 50493222
Lymphangioleiomyomatosis 23.43 10.27 10 111738 156 50493220
Stereotypy 23.40 10.27 13 111735 369 50493007
Intentional product misuse 23.36 10.27 180 111568 46554 50446822
Borderline personality disorder 23.19 10.27 16 111732 672 50492704
Polycystic ovaries 23.13 10.27 28 111720 2456 50490920
Nasal disorder 23.12 10.27 27 111721 2281 50491095
Mitochondrial cytopathy 23.11 10.27 11 111737 224 50493152
Bursitis 23.02 10.27 10 111738 22125 50471251
Cerebral ventricle dilatation 23.01 10.27 18 111730 919 50492457
Injection site rash 22.97 10.27 4 111744 16173 50477203
Miosis 22.88 10.27 46 111702 6264 50487112
Growth retardation 22.85 10.27 19 111729 1059 50492317
Drug eruption 22.81 10.27 108 111640 23498 50469878
Hypothyroidism 22.72 10.27 141 111607 33984 50459392
Surgery 22.62 10.27 20 111728 30185 50463191
Red blood cell sedimentation rate increased 22.61 10.27 19 111729 29397 50463979
Mutism 22.57 10.27 21 111727 1360 50492016
Conductive deafness 22.49 10.27 8 111740 74 50493302
Asthma 22.48 10.27 111 111637 89226 50404150
Anaemia macrocytic 22.46 10.27 28 111720 2531 50490845
Right ventricular failure 22.41 10.27 4 111744 15889 50477487
Product use in unapproved indication 22.08 10.27 369 111379 115450 50377926
Conversion disorder 21.82 10.27 22 111726 1574 50491802
Illiteracy 21.73 10.27 6 111742 21 50493355
Macular degeneration 21.70 10.27 3 111745 14385 50478991
Injection site haemorrhage 21.64 10.27 10 111738 21336 50472040
Pancreatitis acute 21.61 10.27 107 111641 23705 50469671
Influenza B virus test positive 21.59 10.27 11 111737 261 50493115
Therapeutic product effective for unapproved indication 21.42 10.27 8 111740 86 50493290
Pulmonary arterial hypertension 21.42 10.27 9 111739 20310 50473066
Right ventricular hypertrophy 21.39 10.27 15 111733 647 50492729
Dysgeusia 21.36 10.27 33 111715 38883 50454493
Ulcer 21.21 10.27 9 111739 20191 50473185
Breast cancer 21.12 10.27 39 111709 42851 50450525
Metabolic syndrome 21.09 10.27 20 111728 1327 50492049
Osteoporosis 21.06 10.27 42 111706 44837 50448539
Negativism 21.06 10.27 12 111736 358 50493018
Metastases to liver 21.04 10.27 9 111739 20095 50473281
Urine amphetamine positive 21.02 10.27 7 111741 52 50493324
Neglect of personal appearance 21.02 10.27 8 111740 91 50493285
Blood pressure fluctuation 21.02 10.27 29 111719 35794 50457582
Developmental regression 20.91 10.27 6 111742 25 50493351
Mobility decreased 20.89 10.27 98 111650 79850 50413526
Drug withdrawal syndrome 20.88 10.27 110 111638 24971 50468405
Sinus congestion 20.86 10.27 3 111745 13968 50479408
Cleft uvula 20.83 10.27 5 111743 8 50493368
Memory impairment 20.71 10.27 267 111481 79093 50414283
Agranulocytosis 20.70 10.27 98 111650 21323 50472053
Drug screen false positive 20.69 10.27 16 111732 803 50492573
Brain death 20.61 10.27 28 111720 2755 50490621
Intelligence test abnormal 20.47 10.27 4 111744 0 50493376
Optic nerve hypoplasia 20.47 10.27 4 111744 0 50493376
Anomaly of orbit, congenital 20.47 10.27 4 111744 0 50493376
Gaucher's disease 20.47 10.27 4 111744 0 50493376
Full blood count decreased 20.38 10.27 12 111736 22334 50471042
Gastrooesophageal reflux disease 20.37 10.27 93 111655 76335 50417041
Retinitis pigmentosa 20.34 10.27 8 111740 100 50493276
Flatulence 20.32 10.27 21 111727 29437 50463939
Increased appetite 20.31 10.27 52 111696 8309 50485067
Kidney infection 20.25 10.27 8 111740 18738 50474638
Acute generalised exanthematous pustulosis 20.09 10.27 54 111694 8884 50484492
Reduced facial expression 20.03 10.27 21 111727 1573 50491803
Mitochondrial enzyme deficiency 20.02 10.27 6 111742 30 50493346
Acute kidney injury 19.93 10.27 369 111379 227689 50265687
Sexually inappropriate behaviour 19.92 10.27 8 111740 106 50493270
Neoplasm malignant 19.91 10.27 14 111734 23701 50469675
Hepatic cirrhosis 19.83 10.27 7 111741 17570 50475806
Cerebrovascular accident 19.81 10.27 125 111623 94555 50398821
Thinking abnormal 19.72 10.27 56 111692 9511 50483865
Acquired macroglossia 19.67 10.27 9 111739 167 50493209
Cross sensitivity reaction 19.66 10.27 23 111725 1946 50491430
Macroglossia 19.56 10.27 14 111734 624 50492752
Cardiac steatosis 19.55 10.27 6 111742 33 50493343
Hiatus hernia 19.54 10.27 8 111740 18336 50475040
Knee deformity 19.51 10.27 17 111731 1010 50492366
Oral pain 19.45 10.27 16 111732 25017 50468359
Food interaction 19.21 10.27 14 111734 642 50492734
Perseveration 19.04 10.27 10 111738 253 50493123
Euphoric mood 19.00 10.27 33 111715 4022 50489354
Attention-seeking behaviour 18.93 10.27 7 111741 73 50493303
Transient aphasia 18.84 10.27 6 111742 38 50493338
Sciatica 18.78 10.27 12 111736 21370 50472006
Brachydactyly 18.77 10.27 7 111741 75 50493301
Inappropriate affect 18.74 10.27 15 111733 792 50492584
Congenital hepatomegaly 18.69 10.27 5 111743 15 50493361
Hypoplastic left heart syndrome 18.62 10.27 9 111739 190 50493186
Epileptic encephalopathy 18.59 10.27 10 111738 266 50493110
Lennox-Gastaut syndrome 18.55 10.27 10 111738 267 50493109
Lipids 18.45 10.27 5 111743 16 50493360
Congenital hearing disorder 18.45 10.27 5 111743 16 50493360
Hip fracture 18.44 10.27 18 111730 25913 50467463
Limb discomfort 18.39 10.27 16 111732 24341 50469035
Blood insulin increased 18.39 10.27 8 111740 131 50493245
Head titubation 18.34 10.27 14 111734 689 50492687
Clonus 18.30 10.27 33 111715 4142 50489234
Nephrocalcinosis 18.26 10.27 16 111732 958 50492418
Microstomia 18.24 10.27 4 111744 3 50493373
School refusal 18.24 10.27 4 111744 3 50493373
Ascites 18.20 10.27 32 111716 35829 50457547
Full blood count abnormal 18.11 10.27 15 111733 23373 50470003
Pneumocystis jirovecii pneumonia 18.04 10.27 5 111743 14658 50478718
Urine sodium increased 17.98 10.27 7 111741 85 50493291
Lipid metabolism disorder 17.97 10.27 6 111742 45 50493331
Aspiration 17.92 10.27 53 111695 9211 50484165
Haemoptysis 17.90 10.27 18 111730 25555 50467821
Oral herpes 17.71 10.27 12 111736 20713 50472663
Clostridium difficile infection 17.70 10.27 18 111730 25421 50467955
Microphthalmos 17.61 10.27 8 111740 146 50493230
Illness 17.49 10.27 17 111731 24523 50468853
Plasmodium falciparum infection 17.39 10.27 5 111743 21 50493355
Osmolar gap increased 17.39 10.27 5 111743 21 50493355
Rectal haemorrhage 17.32 10.27 37 111711 38521 50454855
Prominent epicanthal folds 17.21 10.27 6 111742 52 50493324
False positive investigation result 17.21 10.27 12 111736 513 50492863
Monocyte count decreased 17.14 10.27 21 111727 1865 50491511
Pulmonary mass 17.13 10.27 10 111738 18695 50474681
Bladder sphincter atony 17.08 10.27 8 111740 157 50493219
Tooth infection 17.02 10.27 5 111743 14107 50479269
Acute myeloid leukaemia 17.01 10.27 6 111742 15068 50478308
Hypersomnia 17.00 10.27 73 111675 15241 50478135
Ligament laxity 16.99 10.27 8 111740 159 50493217
Micrognathia 16.98 10.27 9 111739 232 50493144
Opisthotonus 16.95 10.27 10 111738 319 50493057
Dehydration 16.86 10.27 236 111512 152213 50341163
VIth nerve paralysis 16.86 10.27 14 111734 779 50492597
Spina bifida occulta 16.82 10.27 4 111744 6 50493370
Benign congenital hypotonia 16.82 10.27 6 111742 56 50493320
Drug level changed 16.81 10.27 8 111740 163 50493213
Vomiting 16.80 10.27 839 110909 459919 50033457
Laryngeal stenosis 16.79 10.27 14 111734 783 50492593
Creatinine renal clearance decreased 16.73 10.27 3 111745 11878 50481498
Tachyphrenia 16.72 10.27 17 111731 1228 50492148
Musculoskeletal discomfort 16.69 10.27 6 111742 14892 50478484
Tendonitis 16.67 10.27 8 111740 16697 50476679
Transfusion 16.65 10.27 4 111744 12901 50480475
Parkinsonian gait 16.62 10.27 11 111737 431 50492945
Renal failure 16.54 10.27 153 111595 106480 50386896
Device issue 16.49 10.27 12 111736 19960 50473416
Anotia 16.44 10.27 4 111744 7 50493369
Incontinence 16.42 10.27 54 111694 9931 50483445
Schizoaffective disorder bipolar type 16.41 10.27 7 111741 109 50493267
Lip erosion 16.39 10.27 14 111734 810 50492566
Dysphoria 16.36 10.27 34 111714 4740 50488636
Bipolar II disorder 16.34 10.27 9 111739 251 50493125
Renal hypoplasia 16.22 10.27 5 111743 28 50493348
Urine calcium/creatinine ratio increased 16.18 10.27 7 111741 113 50493263
Shock 16.13 10.27 89 111659 20561 50472815
Ketosis-prone diabetes mellitus 16.09 10.27 4 111744 8 50493368
Pancreatic injury 16.07 10.27 5 111743 29 50493347
Lipids abnormal 15.90 10.27 9 111739 265 50493111
Prothrombin time shortened 15.87 10.27 19 111729 1648 50491728
Self-injurious ideation 15.86 10.27 22 111726 2207 50491169
Bacteraemia 15.86 10.27 6 111742 14427 50478949
Blood triglycerides increased 15.84 10.27 58 111690 11254 50482122
Megakaryocytes abnormal 15.79 10.27 5 111743 31 50493345
Electrocardiogram J wave abnormal 15.78 10.27 4 111744 9 50493367
Head circumference abnormal 15.78 10.27 4 111744 9 50493367
Eye pain 15.74 10.27 24 111724 28425 50464951
Chorea 15.68 10.27 17 111731 1323 50492053
Faeces discoloured 15.67 10.27 8 111740 16116 50477260
Saccadic eye movement 15.63 10.27 6 111742 70 50493306
Cardiac disorder 15.60 10.27 46 111702 42933 50450443
Infusion site pain 15.59 10.27 4 111744 12342 50481034
Asphyxia 15.58 10.27 36 111712 5391 50487985
Coronary artery disease 15.57 10.27 26 111722 29700 50463676
Serositis 15.56 10.27 12 111736 600 50492776
Dysphagia 15.52 10.27 249 111499 77269 50416107
Hyperphagia 15.47 10.27 18 111730 1514 50491862
Drug level fluctuating 15.45 10.27 10 111738 377 50492999
Joint range of motion decreased 15.44 10.27 11 111737 18501 50474875
Vascular encephalopathy 15.38 10.27 10 111738 380 50492996
Intestinal ischaemia 15.37 10.27 41 111707 6716 50486660
Sinus disorder 15.36 10.27 11 111737 18447 50474929
Congenital myopia 15.35 10.27 3 111745 0 50493376
Cognitive linguistic deficit 15.35 10.27 3 111745 0 50493376
Alpers disease 15.35 10.27 3 111745 0 50493376
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 15.35 10.27 3 111745 0 50493376
Rhinotracheitis 15.35 10.27 3 111745 0 50493376
Social (pragmatic) communication disorder 15.35 10.27 3 111745 0 50493376
Diabetic encephalopathy 15.35 10.27 3 111745 0 50493376
Cryptorchism 15.35 10.27 3 111745 0 50493376
Blood 1,25-dihydroxycholecalciferol decreased 15.35 10.27 3 111745 0 50493376
Tibial torsion 15.35 10.27 3 111745 0 50493376
Carnitine palmitoyltransferase deficiency 15.35 10.27 3 111745 0 50493376
Mixed deafness 15.35 10.27 3 111745 0 50493376
Congenital cutis laxa 15.35 10.27 3 111745 0 50493376
Injection site urticaria 15.35 10.27 4 111744 12213 50481163
Regressive behaviour 15.33 10.27 6 111742 74 50493302
Drug dependence 15.32 10.27 85 111663 19674 50473702
Drug monitoring procedure incorrectly performed 15.29 10.27 7 111741 130 50493246
Rib fracture 15.29 10.27 12 111736 19209 50474167
Clonic convulsion 15.25 10.27 12 111736 618 50492758
Device related infection 15.20 10.27 14 111734 20721 50472655
Emotional disorder 15.18 10.27 59 111689 11777 50481599
Sneezing 15.16 10.27 6 111742 14038 50479338
Heart disease congenital 15.13 10.27 16 111732 1210 50492166
Hospitalisation 15.10 10.27 88 111660 67849 50425527
Live birth 15.08 10.27 74 111674 16334 50477042
Systemic inflammatory response syndrome 15.06 10.27 34 111714 5015 50488361
Epileptic psychosis 15.03 10.27 5 111743 37 50493339
Developmental coordination disorder 15.03 10.27 5 111743 37 50493339
Joint effusion 15.01 10.27 5 111743 13016 50480360
Diabetes mellitus 14.98 10.27 170 111578 48863 50444513
Premature baby 14.97 10.27 80 111668 18257 50475119
Immunodeficiency 14.95 10.27 7 111741 14821 50478555
Erythema multiforme 14.94 10.27 49 111699 9001 50484375
Otitis media 14.93 10.27 31 111717 4318 50489058
Glaucoma 14.92 10.27 8 111740 15678 50477698
Magnetic resonance imaging head abnormal 14.89 10.27 19 111729 1758 50491618
Hepatomegaly 14.83 10.27 55 111693 10738 50482638
Acidosis 14.80 10.27 53 111695 10174 50483202
Mental disability 14.77 10.27 6 111742 82 50493294
Sinus bradycardia 14.75 10.27 63 111685 13120 50480256
Blood urea decreased 14.73 10.27 21 111727 2161 50491215
Autonomic nervous system imbalance 14.72 10.27 22 111726 2363 50491013
Fine motor delay 14.69 10.27 7 111741 143 50493233
Electrocardiogram T wave inversion 14.58 10.27 26 111722 3235 50490141
Dysphonia 14.58 10.27 41 111707 38851 50454525
Pulmonary valve stenosis congenital 14.56 10.27 7 111741 146 50493230
Generalised anxiety disorder 14.54 10.27 19 111729 1801 50491575
Simple partial seizures 14.51 10.27 11 111737 536 50492840
Mucosal erosion 14.49 10.27 16 111732 1271 50492105
Congenital eye disorder 14.49 10.27 4 111744 14 50493362
Poor personal hygiene 14.48 10.27 9 111739 316 50493060
Decreased activity 14.45 10.27 34 111714 5153 50488223
Hypoproteinaemia 14.45 10.27 19 111729 1812 50491564
Rash morbilliform 14.45 10.27 24 111724 2822 50490554
Gastric disorder 14.43 10.27 27 111721 29521 50463855
Electrocardiogram QRS complex shortened 14.41 10.27 10 111738 424 50492952
Tubo-ovarian abscess 14.40 10.27 9 111739 319 50493057
Grunting 14.40 10.27 8 111740 227 50493149
Bradypnoea 14.38 10.27 25 111723 3049 50490327
Incoherent 14.35 10.27 30 111718 4200 50489176
Intestinal strangulation 14.33 10.27 6 111742 89 50493287
Nodule 14.32 10.27 10 111738 16993 50476383
Adenoidal hypertrophy 14.27 10.27 5 111743 44 50493332
Diverticulum 14.27 10.27 3 111745 10611 50482765
Congenital nipple anomaly 14.27 10.27 4 111744 15 50493361
Choreoathetosis 14.27 10.27 10 111738 431 50492945
Dry eye 14.25 10.27 31 111717 32064 50461312
Gliosis 14.15 10.27 8 111740 235 50493141
Acute myocardial infarction 14.08 10.27 27 111721 29246 50464130
Hydrocephalus 14.01 10.27 32 111716 4756 50488620
Faecal vomiting 13.99 10.27 11 111737 566 50492810
Gallbladder disorder 13.90 10.27 10 111738 16732 50476644
Candida infection 13.84 10.27 19 111729 23504 50469872
Quadriparesis 13.84 10.27 18 111730 1698 50491678
Idiosyncratic drug reaction 13.83 10.27 12 111736 709 50492667
Haemorrhoids 13.81 10.27 13 111735 19040 50474336
Thought blocking 13.81 10.27 6 111742 98 50493278
Amniocentesis abnormal 13.81 10.27 6 111742 98 50493278
Hyperkalaemia 13.74 10.27 57 111691 48032 50445344
Ebstein's anomaly 13.69 10.27 4 111744 18 50493358
Suspected suicide attempt 13.59 10.27 6 111742 102 50493274
Tachypnoea 13.58 10.27 66 111682 14511 50478865
Accidental poisoning 13.58 10.27 11 111737 591 50492785
Intervertebral disc protrusion 13.55 10.27 15 111733 20378 50472998
Withdrawal catatonia 13.37 10.27 5 111743 54 50493322
Congenital laryngeal stridor 13.37 10.27 5 111743 54 50493322
Crying 13.36 10.27 84 111664 20332 50473044
Maternal exposure during breast feeding 13.36 10.27 25 111723 3229 50490147
Coma hepatic 13.35 10.27 11 111737 605 50492771
Spinal fracture 13.33 10.27 9 111739 15564 50477812
Hypoglycaemia neonatal 13.31 10.27 13 111735 895 50492481
Malignant melanoma 13.30 10.27 3 111745 10105 50483271
Injection site warmth 13.29 10.27 7 111741 13859 50479517
Deja vu 13.29 10.27 5 111743 55 50493321
Blood pyruvic acid increased 13.28 10.27 3 111745 3 50493373
Niemann-Pick disease 13.28 10.27 3 111745 3 50493373
Cerebral palsy 13.28 10.27 6 111742 108 50493268
Procedural pain 13.23 10.27 7 111741 13825 50479551
Tympanic membrane disorder 13.23 10.27 7 111741 180 50493196
Childhood asthma 13.21 10.27 5 111743 56 50493320
Blood sodium increased 13.20 10.27 21 111727 2381 50490995
Therapy interrupted 13.19 10.27 15 111733 20137 50473239
Coma acidotic 13.13 10.27 6 111742 111 50493265
Heart rate irregular 13.13 10.27 14 111734 19346 50474030
Copper deficiency 13.13 10.27 5 111743 57 50493319
Gamma-glutamyltransferase increased 13.12 10.27 111 111637 29512 50463864
Haemorrhage 13.10 10.27 67 111681 53374 50440002
Scoliosis 13.08 10.27 38 111710 6538 50486838
Cell death 13.06 10.27 20 111728 2195 50491181
Activated partial thromboplastin time abnormal 12.98 10.27 6 111742 114 50493262
Febrile convulsion 12.98 10.27 9 111739 381 50492995
Blood citric acid increased 12.97 10.27 5 111743 59 50493317
Oral candidiasis 12.91 10.27 11 111737 16904 50476472
Device difficult to use 12.88 10.27 3 111745 9883 50483493
Status migrainosus 12.84 10.27 6 111742 117 50493259
Cortical visual impairment 12.82 10.27 3 111745 4 50493372
Benign rolandic epilepsy 12.82 10.27 3 111745 4 50493372
Medication error 12.81 10.27 129 111619 35975 50457401
Postictal state 12.81 10.27 13 111735 937 50492439
Transaminases increased 12.72 10.27 105 111643 27719 50465657
Joint hyperextension 12.72 10.27 8 111740 287 50493089
Thermal burn 12.70 10.27 31 111717 4810 50488566
Skin discolouration 12.67 10.27 34 111714 32723 50460653
Perforation 12.65 10.27 13 111735 951 50492425
Intervertebral disc degeneration 12.61 10.27 7 111741 13454 50479922
Hand-eye coordination impaired 12.60 10.27 4 111744 25 50493351
Exostosis 12.54 10.27 5 111743 11648 50481728
Pancreatitis haemorrhagic 12.52 10.27 8 111740 295 50493081
Aura 12.50 10.27 13 111735 965 50492411
Epileptic aura 12.47 10.27 5 111743 66 50493310
Laboratory test abnormal 12.43 10.27 20 111728 23188 50470188
Therapeutic product ineffective for unapproved indication 12.40 10.27 7 111741 205 50493171
Extensor plantar response 12.40 10.27 14 111734 1140 50492236
Disorganised speech 12.35 10.27 13 111735 978 50492398
Therapeutic response changed 12.35 10.27 12 111736 821 50492555
Poisoning deliberate 12.31 10.27 42 111706 7870 50485506
Rash pruritic 12.29 10.27 59 111689 47787 50445589
Anxiety 12.25 10.27 494 111254 177112 50316264
Gout 12.22 10.27 5 111743 11465 50481911
High-pitched crying 12.22 10.27 4 111744 28 50493348
Septic shock 12.21 10.27 75 111673 57100 50436276
Eye swelling 12.13 10.27 16 111732 20128 50473248
Blood bicarbonate increased 12.11 10.27 11 111737 691 50492685
Food refusal 12.08 10.27 8 111740 314 50493062
Enlarged foetal cisterna magna 12.07 10.27 3 111745 6 50493370
Hypersomnia-bulimia syndrome 12.07 10.27 3 111745 6 50493370
Congenital inguinal hernia 12.07 10.27 3 111745 6 50493370
Congenital neurological disorder 12.07 10.27 3 111745 6 50493370
Anuria 12.02 10.27 53 111695 11191 50482185
Dissociative disorder 12.02 10.27 7 111741 218 50493158
Liver function test increased 11.98 10.27 24 111724 25582 50467794
Bronchiolitis 11.98 10.27 20 111728 2361 50491015
Binocular eye movement disorder 11.98 10.27 4 111744 30 50493346
Histiocytic necrotising lymphadenitis 11.98 10.27 4 111744 30 50493346
Glassy eyes 11.95 10.27 5 111743 74 50493302
Amino acid level increased 11.94 10.27 8 111740 320 50493056
Slow response to stimuli 11.92 10.27 12 111736 857 50492519
Presyncope 11.92 10.27 22 111726 24176 50469200
Seasonal allergy 11.88 10.27 9 111739 14667 50478709
Congenital hypothyroidism 11.84 10.27 7 111741 224 50493152
Musculoskeletal chest pain 11.84 10.27 14 111734 18472 50474904
Syndactyly 11.83 10.27 8 111740 325 50493051
Movement disorder 11.83 10.27 73 111675 17559 50475817
Hostility 11.81 10.27 17 111731 1765 50491611
Nose deformity 11.75 10.27 6 111742 143 50493233
Maternal drugs affecting foetus 11.74 10.27 31 111717 5046 50488330
Encapsulating peritoneal sclerosis 11.72 10.27 8 111740 330 50493046
Neutrophilia 11.71 10.27 25 111723 3550 50489826
Toothache 11.70 10.27 12 111736 16882 50476494
Viral infection 11.70 10.27 31 111717 29955 50463421
Sudden death 11.68 10.27 45 111703 8946 50484430
Brain stem syndrome 11.66 10.27 8 111740 333 50493043
Hyperacusis 11.65 10.27 17 111731 1787 50491589
Hyperaldosteronism 11.65 10.27 7 111741 231 50493145
Lung disorder 11.65 10.27 55 111693 44744 50448632
Convulsive threshold lowered 11.57 10.27 8 111740 337 50493039
Inhibitory drug interaction 11.56 10.27 19 111729 2214 50491162
Upper gastrointestinal haemorrhage 11.55 10.27 11 111737 16024 50477352
Cerebral disorder 11.54 10.27 25 111723 3586 50489790
Reproductive tract disorder 11.49 10.27 6 111742 150 50493226
Electrocardiogram J wave 11.47 10.27 3 111745 8 50493368
Tooth development disorder 11.44 10.27 4 111744 35 50493341
Colitis 11.43 10.27 45 111703 38484 50454892
Metastases to lung 11.42 10.27 5 111743 11015 50482361
Blood osmolarity increased 11.35 10.27 6 111742 154 50493222
Limb injury 11.28 10.27 17 111731 20233 50473143
Congenital tracheomalacia 11.24 10.27 4 111744 37 50493339
Procalcitonin increased 11.24 10.27 11 111737 759 50492617
Pharyngeal disorder 11.21 10.27 16 111732 1648 50491728
Congenital gastric anomaly 11.21 10.27 3 111745 9 50493367
Congenital floppy infant 11.21 10.27 3 111745 9 50493367
Intention tremor 11.19 10.27 8 111740 356 50493020
Eosinophilic myocarditis 11.17 10.27 8 111740 357 50493019
Persistent left superior vena cava 11.15 10.27 4 111744 38 50493338
Device dislocation 11.14 10.27 19 111729 21527 50471849
Hepatic steatosis 11.13 10.27 92 111656 24292 50469084
Central nervous system lesion 11.13 10.27 46 111702 9443 50483933
Respiratory tract congestion 11.12 10.27 9 111739 14190 50479186
Sinus tachycardia 11.09 10.27 83 111665 21271 50472105
Antidepressant drug level increased 11.06 10.27 7 111741 254 50493122
Hyporesponsive to stimuli 11.01 10.27 12 111736 940 50492436
Social problem 11.00 10.27 11 111737 779 50492597
Nikolsky's sign 10.97 10.27 5 111743 92 50493284
Eosinophilic pneumonia 10.96 10.27 17 111731 1887 50491489
Body temperature decreased 10.96 10.27 12 111736 16383 50476993
Homicidal ideation 10.94 10.27 16 111732 1686 50491690
Palatal disorder 10.93 10.27 7 111741 259 50493117
Postictal paralysis 10.92 10.27 5 111743 93 50493283
Anomaly of external ear congenital 10.91 10.27 6 111742 167 50493209
Enanthema 10.90 10.27 8 111740 371 50493005
Myoglobinuria 10.89 10.27 7 111741 261 50493115
Ageusia 10.88 10.27 6 111742 11577 50481799
Delusional disorder, unspecified type 10.86 10.27 8 111740 373 50493003
Skin disorder 10.84 10.27 23 111725 24007 50469369
Congenital nail disorder 10.82 10.27 5 111743 95 50493281
Rotator cuff syndrome 10.81 10.27 6 111742 11538 50481838
Scar excision 10.80 10.27 4 111744 42 50493334
Oppositional defiant disorder 10.80 10.27 4 111744 42 50493334
Hypotension 10.76 10.27 629 111119 234840 50258536
Congenital oesophageal anomaly 10.76 10.27 3 111745 11 50493365
Aphthous ulcer 10.69 10.27 5 111743 10592 50482784
Impaired gastric emptying 10.68 10.27 3 111745 8715 50484661
Arrhythmia 10.64 10.27 116 111632 33016 50460360
Tenosynovitis 10.63 10.27 5 111743 10560 50482816
Carpal tunnel syndrome 10.60 10.27 13 111735 16880 50476496
Delusion of reference 10.59 10.27 5 111743 100 50493276
Parkinsonian rest tremor 10.59 10.27 5 111743 100 50493276
Toe walking 10.55 10.27 3 111745 12 50493364
Transplant rejection 10.55 10.27 4 111744 9605 50483771
Colitis ulcerative 10.55 10.27 13 111735 16841 50476535
Hepatic adenoma 10.52 10.27 7 111741 277 50493099
Peripheral nerve injury 10.48 10.27 8 111740 394 50492982
Influenza like illness 10.46 10.27 79 111669 57380 50435996
Head deformity 10.45 10.27 5 111743 103 50493273
Hernia 10.43 10.27 4 111744 9539 50483837
Wound infection 10.42 10.27 7 111741 12141 50481235
Disease recurrence 10.40 10.27 78 111670 20003 50473373
Deformity thorax 10.36 10.27 3 111745 13 50493363
Urine calcium decreased 10.36 10.27 3 111745 13 50493363
Dyspepsia 10.36 10.27 109 111639 73988 50419388
Xanthoma 10.32 10.27 4 111744 48 50493328

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1553.84 11.59 1926 121588 91197 29359816
Hyperammonaemia 1170.81 11.59 539 122975 5124 29445889
Drug interaction 925.61 11.59 2331 121183 195054 29255959
Foetal anticonvulsant syndrome 921.38 11.59 295 123219 869 29450144
Dysmorphism 902.54 11.59 371 123143 2600 29448413
Aggression 799.58 11.59 859 122655 34682 29416331
Hyperammonaemic encephalopathy 727.54 11.59 284 123230 1706 29449307
Neuroleptic malignant syndrome 691.66 11.59 559 122955 15589 29435424
Foetal exposure during pregnancy 667.64 11.59 764 122750 33103 29417910
Status epilepticus 580.97 11.59 428 123086 10366 29440647
Autism spectrum disorder 580.88 11.59 243 123271 1789 29449224
Somnolence 534.18 11.59 1198 122316 92757 29358256
Speech disorder developmental 491.84 11.59 212 123302 1695 29449318
Epilepsy 459.74 11.59 471 123043 17961 29433052
Developmental delay 438.47 11.59 213 123301 2305 29448708
Dyspnoea 427.77 11.59 442 123072 326290 29124723
Generalised tonic-clonic seizure 420.29 11.59 457 123057 18682 29432331
Ammonia increased 393.62 11.59 232 123282 3799 29447214
Learning disorder 384.71 11.59 149 123365 873 29450140
Abnormal behaviour 377.19 11.59 474 123040 22653 29428360
Sopor 376.60 11.59 334 123180 10600 29440413
Diarrhoea 375.53 11.59 506 123008 332192 29118821
Mania 375.29 11.59 302 123212 8361 29442652
Psychomotor retardation 373.80 11.59 202 123312 2774 29448239
Agitation 336.83 11.59 694 122820 50610 29400403
Intellectual disability 331.80 11.59 138 123376 999 29450014
Cognitive disorder 330.88 11.59 448 123066 23051 29427962
Extrapyramidal disorder 330.26 11.59 309 123205 10522 29440491
Language disorder 329.96 11.59 162 123352 1797 29449216
Psychotic disorder 328.46 11.59 415 123099 19939 29431074
Sedation 323.24 11.59 381 123133 17024 29433989
Parkinsonism 320.11 11.59 256 123258 7022 29443991
Granulocytopenia 316.47 11.59 235 123279 5759 29445254
Behaviour disorder 301.29 11.59 188 123326 3428 29447585
Depression 293.46 11.59 901 122613 84246 29366767
Febrile neutropenia 282.00 11.59 62 123452 112178 29338835
Death 275.66 11.59 642 122872 341442 29109571
Arthralgia 272.68 11.59 121 123393 139496 29311517
Disturbance in attention 268.12 11.59 386 123128 21038 29429975
Psychomotor skills impaired 267.31 11.59 156 123358 2505 29448508
Coma 255.72 11.59 531 122983 38919 29412094
Schizophrenia 253.28 11.59 214 123300 6351 29444662
Petit mal epilepsy 251.00 11.59 151 123363 2571 29448442
Attention deficit hyperactivity disorder 244.16 11.59 138 123376 2079 29448934
Acute kidney injury 242.60 11.59 463 123051 264804 29186209
Congenital nose malformation 231.35 11.59 68 123446 134 29450879
Nausea 227.04 11.59 550 122964 288705 29162308
Hypospadias 222.57 11.59 145 123369 2857 29448156
Fatigue 222.43 11.59 637 122877 316184 29134829
Dysgraphia 222.12 11.59 126 123388 1912 29449101
Salivary hypersecretion 221.30 11.59 209 123305 7200 29443813
Toxicity to various agents 216.89 11.59 1352 122162 172309 29278704
Anaemia 214.72 11.59 317 123197 200634 29250379
Irritability 209.82 11.59 351 123163 21801 29429212
Psychomotor hyperactivity 204.94 11.59 210 123304 8003 29443010
Multiple-drug resistance 203.85 11.59 152 123362 3748 29447265
Antipsychotic drug level increased 202.95 11.59 141 123373 3102 29447911
Atrial fibrillation 202.36 11.59 94 123420 105552 29345461
Drug level increased 201.53 11.59 315 123199 18472 29432541
Myocardial infarction 197.95 11.59 107 123407 110189 29340824
Drug level decreased 195.78 11.59 181 123333 6066 29444947
Intentional overdose 192.95 11.59 468 123046 38060 29412953
Intentional self-injury 191.42 11.59 248 123266 12213 29438800
Ataxia 189.25 11.59 243 123271 11860 29439153
Pain 186.42 11.59 267 123247 171165 29279848
Hypertelorism 184.12 11.59 74 123440 485 29450528
Akathisia 184.04 11.59 181 123333 6561 29444452
Cardiac failure congestive 183.00 11.59 47 123467 76534 29374479
Speech disorder 180.67 11.59 340 123174 23176 29427837
Tremor 175.42 11.59 689 122825 72849 29378164
Suicide attempt 174.72 11.59 418 123096 33692 29417321
Mental impairment 174.50 11.59 203 123311 8938 29442075
Electroencephalogram abnormal 171.19 11.59 112 123402 2223 29448790
Depressed level of consciousness 170.51 11.59 435 123079 36507 29414506
Gastrointestinal haemorrhage 169.78 11.59 60 123454 79473 29371540
Hypotonia 169.53 11.59 175 123339 6727 29444286
Pneumonia 169.28 11.59 726 122788 319446 29131567
Pain in extremity 167.03 11.59 130 123384 110303 29340710
Overdose 164.55 11.59 715 122799 79104 29371909
Blood creatine phosphokinase increased 163.71 11.59 455 123059 40189 29410824
Neuropathy peripheral 161.46 11.59 48 123466 70979 29380034
Anticonvulsant drug level increased 158.06 11.59 90 123424 1376 29449637
Enuresis 157.79 11.59 102 123412 1982 29449031
Astigmatism 156.32 11.59 78 123436 898 29450115
Delusion 155.03 11.59 212 123302 11004 29440009
Catatonia 154.84 11.59 137 123377 4331 29446682
Hallucination, auditory 152.17 11.59 194 123320 9399 29441614
Muscle rigidity 150.36 11.59 191 123323 9220 29441793
Anticonvulsant drug level decreased 147.34 11.59 76 123438 943 29450070
Dystonia 146.58 11.59 192 123322 9557 29441456
Motor developmental delay 146.37 11.59 66 123448 594 29450419
Talipes 146.34 11.59 92 123422 1700 29449313
Tardive dyskinesia 145.08 11.59 142 123372 5116 29445897
Product residue present 144.09 11.59 104 123410 2435 29448578
Malignant neoplasm progression 144.05 11.59 64 123450 73795 29377218
Antipsychotic drug level below therapeutic 140.62 11.59 93 123421 1881 29449132
Partial seizures 139.91 11.59 122 123392 3781 29447232
Disease progression 139.02 11.59 85 123429 81831 29369182
Product substitution issue 138.46 11.59 181 123333 8991 29442022
Neurodevelopmental disorder 136.66 11.59 52 123462 288 29450725
Dyspraxia 135.25 11.59 54 123460 347 29450666
Strabismus 134.32 11.59 80 123434 1336 29449677
Interstitial lung disease 131.18 11.59 39 123475 57679 29393334
Foot deformity 131.01 11.59 119 123395 3896 29447117
Wrong patient received product 130.71 11.59 94 123420 2188 29448825
Lip disorder 129.87 11.59 52 123462 337 29450676
Dyskinesia 128.71 11.59 269 123245 19792 29431221
Joint swelling 127.43 11.59 26 123488 49604 29401409
Mental disorder 126.89 11.59 208 123306 12697 29438316
Asthenia 126.88 11.59 467 123047 214783 29236230
Learning disability 125.54 11.59 48 123466 270 29450743
Paranoia 125.05 11.59 179 123335 9698 29441315
Peripheral swelling 123.08 11.59 56 123458 63683 29387330
Treatment noncompliance 123.08 11.59 296 123218 23931 29427082
Renal failure 119.84 11.59 194 123320 118405 29332608
Myopia 119.09 11.59 65 123449 911 29450102
Delirium 118.32 11.59 398 123116 38999 29412014
Cryptorchism 118.17 11.59 83 123431 1859 29449154
Plasma cell myeloma 117.68 11.59 10 123504 37105 29413908
Encephalopathy 117.63 11.59 340 123174 30703 29420310
Drug reaction with eosinophilia and systemic symptoms 117.29 11.59 318 123196 27674 29423339
Infusion related reaction 116.89 11.59 21 123493 43865 29407148
Communication disorder 116.56 11.59 89 123425 2276 29448737
Cough 116.52 11.59 220 123294 126507 29324506
Myoclonic epilepsy 116.39 11.59 64 123450 911 29450102
Chest pain 116.12 11.59 180 123334 111793 29339220
Euphoric mood 116.09 11.59 121 123393 4704 29446309
Joint laxity 115.33 11.59 48 123466 348 29450665
Thrombosis 111.66 11.59 22 123492 43023 29407990
Educational problem 111.50 11.59 51 123463 476 29450537
Congenital oral malformation 111.17 11.59 26 123488 6 29451007
Dysarthria 110.86 11.59 332 123182 30579 29420434
Altered state of consciousness 110.85 11.59 252 123262 19637 29431376
Hypotonia neonatal 109.77 11.59 67 123447 1172 29449841
Pruritus 109.05 11.59 201 123313 116648 29334365
Fanconi syndrome 108.33 11.59 73 123441 1525 29449488
Sudden unexplained death in epilepsy 105.59 11.59 47 123467 409 29450604
Bradyphrenia 105.57 11.59 108 123406 4106 29446907
Disinhibition 104.72 11.59 87 123427 2520 29448493
Restlessness 104.47 11.59 263 123251 21882 29429131
Back pain 103.60 11.59 167 123347 102117 29348896
Obsessive-compulsive disorder 103.42 11.59 111 123403 4465 29446548
Thinking abnormal 99.46 11.59 116 123398 5120 29445893
Myocarditis 98.94 11.59 170 123344 10786 29440227
Myalgia 98.73 11.59 98 123416 73921 29377092
Suicidal ideation 98.36 11.59 344 123170 34372 29416641
Low set ears 97.87 11.59 44 123470 393 29450620
Coordination abnormal 97.60 11.59 134 123380 6980 29444033
Anticonvulsant drug level below therapeutic 97.08 11.59 49 123465 579 29450434
Schizoaffective disorder 96.62 11.59 59 123455 1033 29449980
Priapism 96.43 11.59 106 123408 4382 29446631
Abdominal pain 95.40 11.59 271 123243 135086 29315927
Oedema peripheral 94.96 11.59 180 123334 103377 29347636
Acute myocardial infarction 94.37 11.59 42 123472 48396 29402617
Focal dyscognitive seizures 94.37 11.59 61 123453 1185 29449828
Sepsis 93.85 11.59 295 123219 142387 29308626
Disorientation 93.82 11.59 304 123210 29211 29421802
Drug level below therapeutic 93.72 11.59 102 123412 4169 29446844
Drooling 93.63 11.59 87 123427 2934 29448079
Fine motor delay 93.21 11.59 36 123478 209 29450804
Coronary artery disease 93.13 11.59 34 123480 44156 29406857
Pectus excavatum 92.86 11.59 35 123479 188 29450825
Hypertonia 92.08 11.59 96 123418 3733 29447280
Congenital foot malformation 91.80 11.59 41 123473 360 29450653
Ear disorder 90.70 11.59 60 123454 1214 29449799
Cardiac failure 90.53 11.59 119 123395 79168 29371845
Hypermetropia 89.42 11.59 41 123473 385 29450628
Congenital hand malformation 88.84 11.59 45 123469 536 29450477
Drug ineffective 87.68 11.59 2057 121457 361113 29089900
Myoclonus 87.16 11.59 180 123334 13129 29437884
Anticonvulsant drug level above therapeutic 86.44 11.59 44 123470 530 29450483
Pneumonia aspiration 85.71 11.59 342 123172 36395 29414618
Chest discomfort 84.78 11.59 43 123471 45940 29405073
Scoliosis 84.67 11.59 73 123441 2227 29448786
Asterixis 83.90 11.59 54 123460 1041 29449972
Psychogenic seizure 83.22 11.59 37 123477 321 29450692
Mucosal inflammation 82.25 11.59 16 123498 31579 29419434
Hyperkalaemia 82.19 11.59 81 123433 61311 29389702
Prominent epicanthal folds 82.18 11.59 30 123484 145 29450868
Echolalia 82.10 11.59 34 123480 243 29450770
Antipsychotic drug level above therapeutic 81.17 11.59 53 123461 1048 29449965
Dizziness 80.97 11.59 463 123051 189221 29261792
Ligament laxity 79.69 11.59 20 123494 13 29451000
Eosinophilia 79.43 11.59 238 123276 21923 29429090
Disturbance in social behaviour 79.41 11.59 62 123452 1640 29449373
Chills 79.38 11.59 109 123405 71191 29379822
Hypothermia 79.06 11.59 140 123374 9099 29441914
Increased appetite 78.38 11.59 111 123403 5953 29445060
Pulmonary embolism 78.37 11.59 124 123390 76410 29374603
Impulsive behaviour 78.37 11.59 65 123449 1878 29449135
Blood pressure increased 78.04 11.59 117 123397 73686 29377327
Affect lability 77.73 11.59 83 123431 3319 29447694
Clinodactyly 77.72 11.59 32 123482 225 29450788
Anger 76.93 11.59 152 123362 10738 29440275
Developmental coordination disorder 76.91 11.59 29 123485 156 29450857
Bipolar disorder 76.36 11.59 81 123433 3214 29447799
Drug withdrawal convulsions 76.23 11.59 52 123462 1109 29449904
Prostate cancer 75.40 11.59 9 123505 25518 29425495
Oppositional defiant disorder 75.04 11.59 39 123475 492 29450521
Prescribed overdose 73.56 11.59 131 123383 8552 29442461
Fine motor skill dysfunction 73.45 11.59 57 123457 1494 29449519
Epistaxis 72.99 11.59 65 123449 51639 29399374
Stereotypy 72.51 11.59 41 123473 618 29450395
Headache 72.49 11.59 428 123086 173579 29277434
Hypernatraemia 71.19 11.59 118 123396 7268 29443745
Oculogyric crisis 71.02 11.59 53 123461 1308 29449705
Dyspnoea exertional 70.51 11.59 32 123482 36458 29414555
Microcephaly 70.17 11.59 42 123472 708 29450305
Persecutory delusion 68.96 11.59 63 123451 2078 29448935
Obesity 68.87 11.59 137 123377 9726 29441287
Personal relationship issue 68.41 11.59 30 123484 251 29450762
Hypomania 68.11 11.59 63 123451 2112 29448901
Nasal disorder 68.07 11.59 53 123461 1396 29449617
Therapeutic product effect variable 67.94 11.59 59 123455 1818 29449195
Congenital anomaly 67.71 11.59 51 123463 1277 29449736
Influenza 67.54 11.59 46 123468 41835 29409178
Dyslexia 66.71 11.59 31 123483 301 29450712
Stevens-Johnson syndrome 66.68 11.59 185 123329 16312 29434701
Urticaria 66.61 11.59 78 123436 54582 29396431
Muscle spasms 66.10 11.59 106 123408 64976 29386037
Personality disorder 66.02 11.59 47 123467 1076 29449937
Renal impairment 65.59 11.59 152 123362 81181 29369832
Ascites 64.92 11.59 36 123478 36583 29414430
Weight decreased 64.53 11.59 368 123146 150537 29300476
Dysphoria 64.36 11.59 60 123454 2032 29448981
Toxic encephalopathy 63.46 11.59 87 123427 4525 29446488
Nystagmus 63.43 11.59 84 123430 4225 29446788
Cerebrovascular accident 63.43 11.59 142 123372 76769 29374244
Neutrophil count increased 63.26 11.59 169 123345 14573 29436440
Bradykinesia 63.20 11.59 75 123439 3372 29447641
Plagiocephaly 62.83 11.59 34 123480 468 29450545
Bipolar I disorder 62.73 11.59 39 123475 706 29450307
Psoriasis 62.68 11.59 28 123486 32199 29418814
Sleep disorder 62.57 11.59 234 123280 24152 29426861
Ear malformation 62.55 11.59 29 123485 280 29450733
Atonic seizures 62.31 11.59 25 123489 163 29450850
Craniosynostosis 62.19 11.59 29 123485 284 29450729
Hypermobility syndrome 61.47 11.59 30 123484 328 29450685
Decreased eye contact 61.12 11.59 33 123481 452 29450561
Abdominal pain upper 60.39 11.59 101 123413 60892 29390121
Hepatic function abnormal 60.07 11.59 323 123191 38936 29412077
Hypersensitivity 59.75 11.59 80 123434 52823 29398190
Confusional state 59.68 11.59 805 122709 127072 29323941
Pancytopenia 59.66 11.59 165 123349 83003 29368010
Erythema 59.60 11.59 143 123371 75463 29375550
Stupor 59.28 11.59 65 123449 2679 29448334
Melaena 59.21 11.59 28 123486 31148 29419865
Fluid retention 59.11 11.59 13 123501 23547 29427466
Dehydration 58.61 11.59 263 123251 114485 29336528
Nose deformity 58.14 11.59 24 123490 170 29450843
Serotonin syndrome 58.03 11.59 183 123331 17329 29433684
Weight increased 57.98 11.59 531 122983 76136 29374877
Psychiatric symptom 57.92 11.59 69 123445 3115 29447898
Angina pectoris 57.71 11.59 22 123492 27828 29423185
Brain oedema 57.48 11.59 145 123369 12075 29438938
Antipsychotic drug level decreased 57.24 11.59 39 123475 830 29450183
Herpes zoster 57.06 11.59 27 123487 30025 29420988
Postictal psychosis 57.06 11.59 23 123491 152 29450861
Haematochezia 56.52 11.59 43 123471 36940 29414073
Psychotic symptom 56.40 11.59 47 123467 1367 29449646
Hypoaesthesia 56.28 11.59 85 123429 53382 29397631
Eosinophilic pleural effusion 56.19 11.59 24 123490 187 29450826
Sedation complication 56.16 11.59 45 123469 1237 29449776
Arthritis 54.86 11.59 18 123496 25001 29426012
Pressure of speech 54.50 11.59 30 123484 428 29450585
Completed suicide 54.22 11.59 596 122918 89650 29361363
Exposure during pregnancy 54.03 11.59 114 123400 8440 29442573
Blood creatinine increased 53.77 11.59 179 123335 84923 29366090
Sinusitis 53.71 11.59 39 123475 34311 29416702
Septic shock 53.65 11.59 113 123401 62447 29388566
Syncope 53.60 11.59 168 123346 81203 29369810
Musculoskeletal pain 53.47 11.59 27 123487 28926 29422087
Hyperkinesia 53.36 11.59 48 123466 1551 29449462
White blood cell count increased 52.29 11.59 301 123213 37215 29413798
Camptodactyly congenital 52.18 11.59 19 123495 91 29450922
Congenital eyelid malformation 51.84 11.59 16 123498 40 29450973
Reading disorder 51.76 11.59 29 123485 429 29450584
Urinary incontinence 51.68 11.59 169 123345 16312 29434701
Congenital eye disorder 51.66 11.59 20 123494 117 29450896
Upper gastrointestinal haemorrhage 51.26 11.59 14 123500 21900 29429113
Ear infection 51.22 11.59 108 123406 7992 29443021
Chronic kidney disease 51.13 11.59 46 123468 36370 29414643
Loss of personal independence in daily activities 50.88 11.59 226 123288 25214 29425799
Osteonecrosis of jaw 50.85 11.59 5 123509 16505 29434508
Atrial septal defect 50.68 11.59 97 123417 6692 29444321
General physical health deterioration 50.59 11.59 239 123275 102618 29348395
Anaphylactic reaction 50.49 11.59 26 123488 27547 29423466
Haemoptysis 50.00 11.59 33 123481 30517 29420496
Basal cell carcinoma 49.85 11.59 6 123508 16904 29434109
Asocial behaviour 49.50 11.59 16 123498 49 29450964
Rectal haemorrhage 49.27 11.59 43 123471 34506 29416507
Social avoidant behaviour 49.04 11.59 61 123453 2881 29448132
Knee deformity 48.84 11.59 30 123484 531 29450482
Motor dysfunction 48.36 11.59 88 123426 5842 29445171
Drug level changed 48.34 11.59 25 123489 312 29450701
Differential white blood cell count abnormal 48.19 11.59 41 123473 1228 29449785
Hyperacusis 47.84 11.59 33 123481 717 29450296
Tonic convulsion 47.84 11.59 36 123478 900 29450113
Bruxism 47.83 11.59 45 123469 1542 29449471
High arched palate 47.46 11.59 16 123498 58 29450955
Leukopenia 47.26 11.59 393 123121 54810 29396203
Spina bifida 47.18 11.59 25 123489 329 29450684
Swelling 46.69 11.59 47 123467 35236 29415777
Arnold-Chiari malformation 46.65 11.59 24 123490 296 29450717
Cerebral ventricle dilatation 46.38 11.59 34 123480 816 29450197
Diabetes insipidus 46.35 11.59 54 123460 2380 29448633
Gait disturbance 46.17 11.59 489 123025 72860 29378153
Lethargy 45.69 11.59 291 123223 37289 29413724
Rash 45.68 11.59 540 122974 189279 29261734
Cytomegalovirus infection 45.41 11.59 20 123494 23195 29427818
Gaze palsy 45.34 11.59 40 123474 1259 29449754
Hyperosmolar state 44.97 11.59 25 123489 364 29450649
Pneumonitis 44.95 11.59 31 123483 28013 29423000
Congenital hair disorder 44.83 11.59 10 123504 0 29451013
Paraesthesia 44.72 11.59 99 123415 53746 29397267
Malaise 44.43 11.59 439 123075 159163 29291850
Normal pressure hydrocephalus 44.27 11.59 19 123495 150 29450863
Excessive eye blinking 44.19 11.59 26 123488 424 29450589
Memory impairment 44.09 11.59 282 123232 36188 29414825
Homicidal ideation 43.14 11.59 53 123461 2471 29448542
Cytokine release syndrome 43.09 11.59 3 123511 13116 29437897
Arthropathy 43.07 11.59 18 123496 21536 29429477
Multiple congenital abnormalities 43.03 11.59 27 123487 497 29450516
Encopresis 42.84 11.59 18 123496 134 29450879
Cogwheel rigidity 42.84 11.59 38 123476 1205 29449808
Mental status changes 42.79 11.59 271 123243 34656 29416357
Pneumocystis jirovecii pneumonia 42.62 11.59 9 123505 16770 29434243
Abdominal discomfort 42.36 11.59 85 123429 47818 29403195
Cerebellar atrophy 42.24 11.59 26 123488 462 29450551
COVID-19 42.16 11.59 53 123461 35961 29415052
Palmar-plantar erythrodysaesthesia syndrome 41.67 11.59 6 123508 14753 29436260
Haemorrhage 41.57 11.59 78 123436 44994 29406019
Blood prolactin increased 41.52 11.59 41 123473 1493 29449520
Physical assault 41.12 11.59 35 123479 1049 29449964
Confabulation 40.99 11.59 17 123497 122 29450891
Choreoathetosis 40.89 11.59 34 123480 986 29450027
Brugada syndrome 40.43 11.59 29 123485 672 29450341
Respiratory failure 40.33 11.59 239 123275 96892 29354121
Tooth malformation 40.30 11.59 18 123496 158 29450855
Hyperprolactinaemia 40.18 11.59 37 123477 1233 29449780
Delusion of grandeur 40.18 11.59 24 123490 403 29450610
Anxiety 40.03 11.59 538 122976 84827 29366186
Chorea 39.95 11.59 33 123481 948 29450065
Apathy 39.86 11.59 83 123431 6088 29444925
Nipple disorder 39.82 11.59 18 123496 163 29450850
Acute myeloid leukaemia 39.67 11.59 10 123504 16503 29434510
Pancreatitis acute 39.60 11.59 204 123310 24181 29426832
Homicide 39.43 11.59 32 123482 896 29450117
Seizure cluster 39.41 11.59 16 123498 108 29450905
Psoriatic arthropathy 39.17 11.59 7 123507 14684 29436329
Cerebral atrophy 39.17 11.59 65 123449 4007 29447006
Stomatitis 39.05 11.59 59 123455 37054 29413959
Injection site pain 38.77 11.59 47 123467 32399 29418614
Pancreatitis 38.75 11.59 262 123252 34252 29416761
Colitis 38.70 11.59 44 123470 31204 29419809
Executive dysfunction 38.52 11.59 19 123495 213 29450800
Haematuria 38.45 11.59 79 123435 44060 29406953
Neoplasm progression 38.07 11.59 15 123499 18597 29432416
Anisometropia 37.97 11.59 13 123501 50 29450963
Acidosis hyperchloraemic 37.92 11.59 22 123492 349 29450664
Eosinophil count decreased 37.79 11.59 34 123480 1099 29449914
Emotional disorder 37.48 11.59 71 123443 4860 29446153
Logorrhoea 37.43 11.59 47 123467 2241 29448772
Dyscalculia 37.32 11.59 11 123503 22 29450991
Crying 36.96 11.59 74 123440 5277 29445736
Congenital myopia 36.81 11.59 13 123501 56 29450957
Flushing 36.81 11.59 40 123474 28952 29422061
Delusional disorder, unspecified type 36.76 11.59 27 123487 650 29450363
Posture abnormal 36.75 11.59 43 123471 1904 29449109
Oedema 36.51 11.59 71 123443 40412 29410601
International normalised ratio increased 36.50 11.59 82 123432 44290 29406723
Staphylococcal infection 36.40 11.59 41 123473 29199 29421814
Haemoglobin decreased 36.37 11.59 284 123230 108091 29342922
Lung disorder 36.26 11.59 44 123470 30318 29420695
Tumour lysis syndrome 36.20 11.59 7 123507 13877 29437136
Autonomic nervous system imbalance 36.03 11.59 47 123467 2329 29448684
Infantile spasms 35.98 11.59 17 123497 172 29450841
Full blood count decreased 35.96 11.59 11 123503 15981 29435032
Carnitine decreased 35.86 11.59 8 123506 0 29451013
Transient ischaemic attack 35.62 11.59 27 123487 23243 29427770
Bacteraemia 35.34 11.59 12 123502 16311 29434702
Angioedema 35.28 11.59 49 123465 31866 29419147
Emotional disorder of childhood 35.23 11.59 11 123503 29 29450984
Necrosis ischaemic 35.13 11.59 18 123496 220 29450793
Dysgeusia 35.11 11.59 26 123488 22648 29428365
Cellulitis 35.09 11.59 88 123426 45752 29405261
Faecaloma 35.08 11.59 63 123451 4139 29446874
Bronchiolitis 34.97 11.59 50 123464 2705 29448308
Renal disorder 34.87 11.59 26 123488 22569 29428444
Osteoarthritis 34.77 11.59 16 123498 18087 29432926
Monocyte count increased 34.69 11.59 60 123454 3826 29447187
Intelligence test abnormal 34.60 11.59 10 123504 18 29450995
Synovitis 34.33 11.59 3 123511 10887 29440126
Apraxia 34.26 11.59 33 123481 1165 29449848
Heart disease congenital 34.25 11.59 34 123480 1246 29449767
Anaphylactic shock 34.19 11.59 7 123507 13329 29437684
Inappropriate antidiuretic hormone secretion 34.18 11.59 112 123402 10820 29440193
Distractibility 33.80 11.59 19 123495 283 29450730
Flight of ideas 33.79 11.59 20 123494 330 29450683
Sexually inappropriate behaviour 33.73 11.59 21 123493 381 29450632
Dysmetria 33.73 11.59 21 123493 381 29450632
Pneumothorax 33.69 11.59 12 123502 15830 29435183
Congenital astigmatism 33.60 11.59 10 123504 21 29450992
Social (pragmatic) communication disorder 33.58 11.59 13 123501 76 29450937
Product dose omission issue 33.55 11.59 250 123264 96133 29354880
Laboratory test abnormal 33.52 11.59 17 123497 18168 29432845
Arachnodactyly 33.33 11.59 8 123506 3 29451010
Congenital nail disorder 33.26 11.59 11 123503 37 29450976
Psychiatric decompensation 33.14 11.59 36 123478 1468 29449545
Gastrointestinal malformation 33.03 11.59 11 123503 38 29450975
Coloboma 32.98 11.59 15 123499 138 29450875
Torticollis 32.90 11.59 31 123483 1064 29449949
Bone pain 32.90 11.59 18 123496 18434 29432579
Mood altered 32.81 11.59 91 123423 8020 29442993
Hypotension 32.73 11.59 593 122921 193761 29257252
Bronchopulmonary aspergillosis 32.66 11.59 6 123508 12338 29438675
Pleurothotonus 32.37 11.59 30 123484 1008 29450005
Growth retardation 32.34 11.59 37 123477 1599 29449414
Atrial flutter 32.26 11.59 9 123505 13885 29437128
Deep vein thrombosis 32.09 11.59 127 123387 57272 29393741
Heart rate decreased 32.04 11.59 34 123480 24878 29426135
Illiteracy 32.00 11.59 8 123506 5 29451008
Postictal paralysis 31.93 11.59 17 123497 226 29450787
Soliloquy 31.79 11.59 20 123494 370 29450643
Anion gap increased 31.68 11.59 36 123478 1544 29449469
Pharyngeal disorder 31.45 11.59 24 123490 613 29450400
Toe walking 31.38 11.59 7 123507 0 29451013
Nasal septum disorder 31.22 11.59 11 123503 47 29450966
Inguinal hernia 31.08 11.59 79 123435 6609 29444404
Retinal coloboma 30.87 11.59 9 123505 17 29450996
Paradoxical drug reaction 30.84 11.59 47 123467 2694 29448319
Acute coronary syndrome 30.52 11.59 7 123507 12318 29438695
Perseveration 30.47 11.59 13 123501 101 29450912
Postictal state 30.36 11.59 25 123489 715 29450298
Middle insomnia 30.34 11.59 71 123443 5637 29445376
Congenital knee deformity 30.14 11.59 13 123501 104 29450909
Gross motor delay 30.02 11.59 17 123497 257 29450756
Otitis media 29.99 11.59 45 123469 2544 29448469
Intentional product use issue 29.94 11.59 85 123429 42413 29408600
Decreased appetite 29.94 11.59 427 123087 144915 29306098
Drug intolerance 29.69 11.59 103 123411 48276 29402737
Drop attacks 29.69 11.59 22 123492 537 29450476
Dyslipidaemia 29.64 11.59 73 123441 5988 29445025
Pulmonary fibrosis 29.58 11.59 14 123500 15568 29435445
Prognathism 29.42 11.59 13 123501 111 29450902
Hypokalaemia 29.40 11.59 109 123405 50094 29400919
Angina unstable 29.36 11.59 5 123509 10860 29440153
Muscle tone disorder 29.34 11.59 14 123500 145 29450868
Blood pressure fluctuation 29.30 11.59 24 123490 19870 29431143
Rhinorrhoea 29.23 11.59 28 123486 21491 29429522
Amblyopia 29.20 11.59 11 123503 59 29450954
Hepatic adenoma 29.10 11.59 10 123504 39 29450974
Developmental hip dysplasia 29.07 11.59 17 123497 274 29450739
Night sweats 28.99 11.59 13 123501 14919 29436094
Coma scale abnormal 28.95 11.59 52 123462 3417 29447596
Sluggishness 28.88 11.59 48 123466 2963 29448050
Affective disorder 28.87 11.59 49 123465 3077 29447936
Medication error 28.78 11.59 169 123345 21042 29429971
Neural tube defect 28.70 11.59 10 123504 41 29450972
Limb hypoplasia congenital 28.58 11.59 8 123506 12 29451001
Pyrexia 28.34 11.59 951 122563 286671 29164342
Antisocial behaviour 28.12 11.59 17 123497 292 29450721
Myelodysplastic syndrome 28.08 11.59 20 123494 17774 29433239
Cerebral palsy 28.04 11.59 12 123502 94 29450919
Inappropriate affect 27.94 11.59 21 123493 524 29450489
Depressive symptom 27.66 11.59 35 123479 1682 29449331
Balance disorder 27.55 11.59 251 123263 35919 29415094
Drug hypersensitivity 27.50 11.59 170 123344 68236 29382777
Pelvic deformity 27.47 11.59 8 123506 15 29450998
Lymphocyte count increased 27.41 11.59 45 123469 2749 29448264
Frustration tolerance decreased 27.31 11.59 40 123474 2212 29448801
Meningocele 27.27 11.59 9 123505 30 29450983
Anticonvulsant drug level abnormal 27.27 11.59 9 123505 30 29450983
Convulsive threshold lowered 27.17 11.59 20 123494 483 29450530
Intensive care unit acquired weakness 27.01 11.59 26 123488 917 29450096
Retrognathia 26.92 11.59 16 123498 266 29450747
Nephrolithiasis 26.91 11.59 40 123474 25294 29425719
Social problem 26.90 11.59 24 123490 767 29450246
Factor XIII deficiency 26.90 11.59 6 123508 0 29451013
Mutism 26.89 11.59 23 123491 694 29450319
Nasopharyngitis 26.82 11.59 143 123371 59522 29391491
Visuospatial deficit 26.76 11.59 11 123503 77 29450936
Neoplasm malignant 26.73 11.59 19 123495 16906 29434107
Hypotelorism of orbit 26.71 11.59 12 123502 107 29450906
Abdominal distension 26.68 11.59 100 123414 45811 29405202
Cleft palate 26.65 11.59 21 123493 563 29450450
Phobia 26.49 11.59 13 123501 144 29450869
Head titubation 26.46 11.59 16 123498 275 29450738
Deformity thorax 26.41 11.59 9 123505 34 29450979
Brain malformation 26.23 11.59 12 123502 112 29450901
Scaphocephaly 26.21 11.59 8 123506 19 29450994
Speech sound disorder 26.18 11.59 13 123501 148 29450865
Chronic obstructive pulmonary disease 25.94 11.59 86 123428 40869 29410144
Hot flush 25.80 11.59 15 123499 14855 29436158
Angular cheilitis 25.80 11.59 13 123501 153 29450860
Infection 25.79 11.59 201 123313 76550 29374463
Blood potassium decreased 25.74 11.59 17 123497 15717 29435296
Duodenal ulcer 25.52 11.59 4 123510 9234 29441779
Device related infection 25.43 11.59 17 123497 15619 29435394
Aminoaciduria 25.35 11.59 12 123502 122 29450891
Tonic clonic movements 25.32 11.59 25 123489 910 29450103
Staring 25.27 11.59 30 123484 1349 29449664
Oligoasthenozoospermia 25.21 11.59 7 123507 10 29451003
Choking 25.12 11.59 57 123457 4434 29446579
Bicuspid aortic valve 25.11 11.59 14 123500 205 29450808
Negativism 25.11 11.59 17 123497 358 29450655
Rash pruritic 25.05 11.59 34 123480 22329 29428684
Osteomyelitis 24.99 11.59 13 123501 13696 29437317
Dacryostenosis congenital 24.91 11.59 9 123505 42 29450971
Clostridium difficile colitis 24.88 11.59 12 123502 13200 29437813
Strabismus congenital 24.87 11.59 8 123506 24 29450989
Unresponsive to stimuli 24.86 11.59 185 123329 24941 29426072
Renal injury 24.85 11.59 6 123508 10196 29440817
Hypervolaemia 24.82 11.59 22 123492 17523 29433490
Foetal growth restriction 24.73 11.59 51 123463 3715 29447298
Patient isolation 24.63 11.59 8 123506 25 29450988
Post-injection delirium sedation syndrome 24.55 11.59 18 123496 432 29450581
Acute hepatic failure 24.52 11.59 107 123407 11845 29439168
Microstomia 24.48 11.59 6 123508 3 29451010
Choroidal coloboma 24.48 11.59 6 123508 3 29451010
COVID-19 pneumonia 24.40 11.59 5 123509 9517 29441496
Eosinophil count increased 24.40 11.59 77 123437 7292 29443721
Constipation 24.34 11.59 333 123181 113827 29337186
Tic 24.32 11.59 34 123480 1801 29449212
Judgement impaired 24.28 11.59 20 123494 572 29450441
Food interaction 24.26 11.59 24 123490 876 29450137
Anomaly of external ear congenital 24.20 11.59 11 123503 101 29450912
Gout 24.17 11.59 21 123493 16890 29434123
Renal tubular necrosis 24.05 11.59 15 123499 14300 29436713
Inflammation 24.03 11.59 36 123478 22692 29428321
Hallucination, visual 23.95 11.59 125 123389 14890 29436123
Overweight 23.93 11.59 30 123484 1428 29449585
Hypertension 23.86 11.59 343 123171 116271 29334742
Faeces discoloured 23.84 11.59 13 123501 13338 29437675
Selective eating disorder 23.83 11.59 32 123482 1631 29449382
Water intoxication 23.77 11.59 17 123497 392 29450621
Metastases to bone 23.76 11.59 6 123508 9892 29441121
Metabolic syndrome 23.69 11.59 30 123484 1443 29449570
Ventricular tachycardia 23.63 11.59 36 123478 22538 29428475
Metabolic acidosis 23.63 11.59 251 123263 37411 29413602
Congenital scoliosis 23.63 11.59 10 123504 76 29450937
Dry skin 23.61 11.59 38 123476 23269 29427744
Urinary tract infection 23.61 11.59 191 123323 72163 29378850
Condition aggravated 23.60 11.59 788 122726 145507 29305506
Impaired reasoning 23.57 11.59 11 123503 108 29450905
Cerebral haemorrhage 23.53 11.59 61 123453 31365 29419648
Neuralgia 23.53 11.59 8 123506 10866 29440147
Oropharyngeal discomfort 23.52 11.59 40 123474 2516 29448497
Hyponatraemia 23.46 11.59 405 123109 67228 29383785
Aptyalism 23.45 11.59 15 123499 286 29450727
Diabetic hyperosmolar coma 23.38 11.59 16 123498 343 29450670
Cerebral infarction 23.37 11.59 42 123472 24633 29426380
Carnitine deficiency 23.34 11.59 9 123505 52 29450961
Drug level above therapeutic 23.13 11.59 46 123468 3264 29447749
Pulmonary mass 23.10 11.59 8 123506 10740 29440273
Cholestasis 23.07 11.59 39 123475 23423 29427590
Muscular weakness 23.01 11.59 158 123356 61894 29389119
Blood bilirubin increased 22.99 11.59 69 123445 33824 29417189
Candida infection 22.88 11.59 18 123496 15207 29435806
Blood lactic acid increased 22.65 11.59 64 123450 5702 29445311
Grandiosity 22.52 11.59 15 123499 307 29450706
Localised infection 22.50 11.59 15 123499 13801 29437212
Patent ductus arteriosus 22.47 11.59 44 123470 3087 29447926
Drug abuse 22.42 11.59 463 123051 79420 29371593
Congenital neurological disorder 22.41 11.59 5 123509 0 29451013
Meningomyelocele 22.38 11.59 12 123502 162 29450851
Bone marrow failure 22.35 11.59 51 123463 27398 29423615
Ventricular septal defect 22.25 11.59 47 123467 3482 29447531
Pulmonary hypertension 22.18 11.59 27 123487 18581 29432432
Failure to suspend medication 22.11 11.59 16 123498 376 29450637
Congenital genital malformation 21.99 11.59 10 123504 92 29450921
Incontinence 21.90 11.59 58 123456 4974 29446039
Throat irritation 21.73 11.59 5 123509 8780 29442233
Type 2 diabetes mellitus 21.62 11.59 113 123401 13468 29437545
Wrong product administered 21.55 11.59 54 123460 4477 29446536
Subacute endocarditis 21.53 11.59 8 123506 41 29450972
Mood swings 21.52 11.59 73 123441 7178 29443835
Salivary gland enlargement 21.52 11.59 7 123507 22 29450991
Nephropathy toxic 21.46 11.59 9 123505 10747 29440266
Congenital nipple anomaly 21.44 11.59 6 123508 9 29451004
Frequent bowel movements 21.42 11.59 6 123508 9233 29441780
Squamous cell carcinoma 21.40 11.59 8 123506 10243 29440770
Blood osmolarity decreased 21.38 11.59 18 123496 531 29450482
Hyperthermia 21.35 11.59 87 123427 9343 29441670
Transplant rejection 21.33 11.59 6 123508 9206 29441807
Blood triglycerides increased 21.28 11.59 108 123406 12726 29438287
Feeling hot 21.22 11.59 20 123494 15468 29435545
Decreased gait velocity 21.15 11.59 11 123503 139 29450874
Head deformity 21.09 11.59 9 123505 70 29450943
Adrenal insufficiency 21.07 11.59 10 123504 11104 29439909
Conductive deafness 21.01 11.59 11 123503 141 29450872
Self-injurious ideation 20.95 11.59 29 123485 1522 29449491
Basilar artery occlusion 20.87 11.59 9 123505 72 29450941
Refraction disorder 20.84 11.59 7 123507 25 29450988
Flatulence 20.79 11.59 26 123488 17683 29433330
Clostridium difficile infection 20.78 11.59 22 123492 16119 29434894
Brachydactyly 20.76 11.59 12 123502 189 29450824
Febrile bone marrow aplasia 20.73 11.59 3 123511 7348 29443665
Shock haemorrhagic 20.71 11.59 7 123507 9544 29441469
Micrognathia 20.71 11.59 14 123500 294 29450719
Niemann-Pick disease 20.69 11.59 6 123508 11 29451002
Epidermolysis bullosa 20.68 11.59 10 123504 107 29450906
Cardiogenic shock 20.68 11.59 30 123484 19160 29431853
Skin cancer 20.59 11.59 5 123509 8463 29442550
Blood pressure systolic increased 20.55 11.59 24 123490 16821 29434192
Movement disorder 20.51 11.59 91 123423 10146 29440867
Squamous cell carcinoma of skin 20.49 11.59 7 123507 9479 29441534
Haemangioma 20.42 11.59 30 123484 1664 29449349
Intestinal ischaemia 20.42 11.59 68 123446 6624 29444389
Impaired healing 20.41 11.59 16 123498 13542 29437471
Madarosis 20.38 11.59 12 123502 196 29450817
Ageusia 20.36 11.59 6 123508 8932 29442081
Pleural effusion 20.30 11.59 197 123317 71711 29379302
Delusional perception 20.16 11.59 11 123503 154 29450859
Bronchopulmonary disease 20.08 11.59 5 123509 3 29451010
Lacrimal gland enlargement 20.08 11.59 5 123509 3 29451010
Gastric volvulus 20.08 11.59 5 123509 3 29451010
Pneumonia bacterial 20.00 11.59 7 123507 9336 29441677
Cardiac disorder 19.85 11.59 84 123430 37179 29413834
Sensory integrative dysfunction 19.85 11.59 7 123507 30 29450983
Dissociation 19.77 11.59 24 123490 1105 29449908
Diverticulitis 19.75 11.59 27 123487 17677 29433336
Hyperexplexia 19.67 11.59 7 123507 31 29450982
Blood glucose increased 19.56 11.59 155 123359 58829 29392184
Febrile convulsion 19.46 11.59 17 123497 528 29450485
Pasteurella infection 19.44 11.59 6 123508 15 29450998
Gingival hypertrophy 19.37 11.59 29 123485 1636 29449377
Brachycephaly 19.34 11.59 8 123506 57 29450956
Graft versus host disease 19.30 11.59 8 123506 9620 29441393
Aspiration 19.28 11.59 89 123425 10091 29440922
Poverty of speech 19.17 11.59 12 123502 220 29450793
Brain stem auditory evoked response abnormal 19.17 11.59 6 123508 16 29450997
Verbal abuse 19.16 11.59 11 123503 171 29450842
Depressed mood 19.14 11.59 126 123388 16322 29434691
Metastases to liver 19.14 11.59 13 123501 11843 29439170
Tachycardia 19.13 11.59 416 123098 71994 29379019
Mucosal ulceration 19.12 11.59 21 123493 867 29450146
Limb discomfort 19.10 11.59 8 123506 9560 29441453
Venoocclusive liver disease 19.10 11.59 3 123511 6914 29444099
Trismus 19.07 11.59 35 123479 2338 29448675
Type 1 diabetes mellitus 19.01 11.59 45 123469 3599 29447414
Ehlers-Danlos syndrome 18.98 11.59 7 123507 35 29450978
Developmental regression 18.98 11.59 7 123507 35 29450978
Kyphosis congenital 18.97 11.59 5 123509 5 29451008
Energy increased 18.96 11.59 24 123490 1154 29449859
Myelosuppression 18.95 11.59 14 123500 12213 29438800
Myoglobinuria 18.95 11.59 19 123495 705 29450308
Hypoxia 18.90 11.59 118 123396 47261 29403752
Supernumerary nipple 18.82 11.59 7 123507 36 29450977
Hostility 18.78 11.59 20 123494 797 29450216
Mydriasis 18.71 11.59 62 123452 6023 29444990
Hepatitis C virus test positive 18.71 11.59 13 123501 286 29450727
Sarcopenia 18.67 11.59 14 123500 348 29450665
Lennox-Gastaut syndrome 18.66 11.59 7 123507 37 29450976
IVth nerve disorder 18.65 11.59 6 123508 18 29450995
Injection site swelling 18.59 11.59 8 123506 9409 29441604
Contusion 18.54 11.59 67 123447 31028 29419985
Haemorrhoids 18.52 11.59 13 123501 11644 29439369
Presyncope 18.49 11.59 24 123490 16065 29434948
Pain in jaw 18.48 11.59 13 123501 11628 29439385
Iris coloboma 18.41 11.59 6 123508 19 29450994
Suspiciousness 18.40 11.59 13 123501 294 29450719
Cholelithiasis 18.39 11.59 31 123483 18641 29432372
Lymphoma 18.39 11.59 9 123505 9819 29441194
Ammonia abnormal 18.34 11.59 8 123506 66 29450947
Pulmonary oedema 18.33 11.59 104 123410 42631 29408382
Gastric ulcer 18.29 11.59 19 123495 14042 29436971
Gastric disorder 18.29 11.59 11 123503 10693 29440320
Heterophoria 18.24 11.59 8 123506 67 29450946
Aphasia 18.23 11.59 140 123374 19058 29431955
Enterocolitis 18.16 11.59 3 123511 6663 29444350
Toxic epidermal necrolysis 18.15 11.59 134 123380 18019 29432994
Partial seizures with secondary generalisation 18.13 11.59 12 123502 243 29450770
Tonsillitis 18.07 11.59 31 123483 1964 29449049
Psychomotor disadaptation syndrome 18.06 11.59 5 123509 7 29451006
Agranulocytosis 18.03 11.59 146 123368 20194 29430819
Sperm concentration decreased 18.02 11.59 10 123504 145 29450868
Injection site erythema 17.99 11.59 19 123495 13937 29437076
Poor sucking reflex 17.95 11.59 13 123501 306 29450707
Retracted nipple 17.93 11.59 4 123510 0 29451013
Ear, nose and throat examination abnormal 17.93 11.59 4 123510 0 29451013
Laryngeal web 17.93 11.59 4 123510 0 29451013
Dentofacial anomaly 17.93 11.59 4 123510 0 29451013
Phimosis 17.92 11.59 18 123496 669 29450344
Skin ulcer 17.90 11.59 32 123482 18808 29432205
Cataract 17.88 11.59 42 123472 22336 29428677
Syndactyly 17.87 11.59 19 123495 756 29450257
Lower gastrointestinal haemorrhage 17.84 11.59 6 123508 8207 29442806
Hallucination 17.83 11.59 274 123240 44438 29406575
Aura 17.77 11.59 13 123501 311 29450702
Coma blister 17.74 11.59 8 123506 72 29450941
Adenoidectomy 17.71 11.59 9 123505 108 29450905
Retinogram abnormal 17.71 11.59 9 123505 108 29450905
Conjunctival hyperaemia 17.70 11.59 32 123482 2113 29448900
C-reactive protein abnormal 17.68 11.59 3 123511 6533 29444480
Resting tremor 17.65 11.59 17 123497 600 29450413
Congenital inguinal hernia 17.55 11.59 10 123504 153 29450860
Jaundice 17.55 11.59 63 123451 29233 29421780
Tachyphrenia 17.53 11.59 23 123491 1146 29449867
Hyperhomocysteinaemia 17.51 11.59 11 123503 203 29450810
Product administered to patient of inappropriate age 17.49 11.59 36 123478 2619 29448394
Neutropenic sepsis 17.45 11.59 14 123500 11713 29439300
Miosis 17.43 11.59 73 123441 7936 29443077
Simple partial seizures 17.43 11.59 12 123502 260 29450753
Body dysmorphic disorder 17.42 11.59 9 123505 112 29450901
Hypokinesia 17.34 11.59 70 123444 7484 29443529
School refusal 17.34 11.59 6 123508 24 29450989
Compensatory sweating 17.34 11.59 6 123508 24 29450989
Hyperdynamic left ventricle 17.28 11.59 9 123505 114 29450899
Withdrawal syndrome 17.18 11.59 91 123423 10901 29440112
Dementia with Lewy bodies 17.17 11.59 17 123497 621 29450392
Hyporeflexia 17.11 11.59 29 123485 1819 29449194
Injection site reaction 17.10 11.59 13 123501 11175 29439838
Kyphosis 17.02 11.59 22 123492 1080 29449933
Oral candidiasis 16.98 11.59 12 123502 10710 29440303
Tendonitis 16.98 11.59 6 123508 7955 29443058
Necrotising colitis 16.96 11.59 21 123493 987 29450026
Skin exfoliation 16.92 11.59 44 123470 22601 29428412
Rhabdomyolysis 16.91 11.59 352 123162 60456 29390557
Conversion disorder 16.91 11.59 13 123501 336 29450677
Excessive masturbation 16.76 11.59 8 123506 83 29450930
Thought blocking 16.75 11.59 9 123505 122 29450891
Diffuse large B-cell lymphoma 16.71 11.59 3 123511 6273 29444740
Craniofacial deformity 16.67 11.59 8 123506 84 29450929
Incoherent 16.64 11.59 46 123468 4046 29446967
Dyspepsia 16.61 11.59 67 123447 30058 29420955
Muscle twitching 16.57 11.59 72 123442 7954 29443059
Eating disorder 16.51 11.59 67 123447 7180 29443833
Ankyloglossia congenital 16.48 11.59 12 123502 285 29450728
Immune reconstitution inflammatory syndrome 16.43 11.59 6 123508 7796 29443217
Dermatitis 16.42 11.59 6 123508 7792 29443221
Coronary artery occlusion 16.38 11.59 11 123503 10083 29440930
Kidney malformation 16.23 11.59 10 123504 178 29450835
Polydipsia 16.17 11.59 41 123473 3424 29447589
Postural tremor 16.08 11.59 12 123502 296 29450717
Maternal drugs affecting foetus 16.07 11.59 44 123470 3849 29447164
Neutrophil Pelger-Huet anomaly present 16.03 11.59 11 123503 237 29450776
Chromaturia 15.88 11.59 18 123496 12784 29438229
Erectile dysfunction 15.82 11.59 129 123385 17880 29433133
Irregular sleep phase 15.82 11.59 7 123507 60 29450953
Congenital cerebral cyst 15.80 11.59 5 123509 14 29450999
Epileptic aura 15.80 11.59 5 123509 14 29450999
Vasoplegia syndrome 15.77 11.59 25 123489 1483 29449530
Neurological decompensation 15.77 11.59 33 123481 2429 29448584
Automatism 15.74 11.59 8 123506 96 29450917
Reduced facial expression 15.73 11.59 17 123497 689 29450324
Throat tightness 15.72 11.59 5 123509 7086 29443927
Separation anxiety disorder 15.70 11.59 4 123510 3 29451010
Congenital jaw malformation 15.70 11.59 4 123510 3 29451010
Hyperglycinaemia 15.70 11.59 4 123510 3 29451010
Joint hyperextension 15.60 11.59 8 123506 98 29450915
Pancreatitis haemorrhagic 15.54 11.59 12 123502 312 29450701
Therapeutic response changed 15.51 11.59 12 123502 313 29450700
Schizoaffective disorder bipolar type 15.51 11.59 6 123508 35 29450978
Otitis media acute 15.49 11.59 14 123500 455 29450558
Peripheral sensory neuropathy 15.47 11.59 3 123511 5936 29445077
Myocardial ischaemia 15.43 11.59 27 123487 16001 29435012
Cardiac failure chronic 15.37 11.59 4 123510 6463 29444550
Delayed fontanelle closure 15.37 11.59 6 123508 36 29450977
Circadian rhythm sleep disorder 15.34 11.59 13 123501 387 29450626
Blood urine present 15.34 11.59 11 123503 9744 29441269
Hyperreflexia 15.30 11.59 35 123479 2737 29448276
Opsoclonus myoclonus 15.24 11.59 7 123507 66 29450947
Pulmonary arterial hypertension 15.24 11.59 6 123508 7443 29443570
Diarrhoea haemorrhagic 15.23 11.59 3 123511 5871 29445142
Intermittent explosive disorder 15.17 11.59 4 123510 4 29451009
Drug resistance 15.16 11.59 147 123367 21393 29429620
Myopathy 15.15 11.59 13 123501 10520 29440493
Auditory disorder 15.11 11.59 11 123503 261 29450752
Epileptic psychosis 15.08 11.59 5 123509 17 29450996
Abnormal labour affecting foetus 15.08 11.59 5 123509 17 29450996
Rebound psychosis 15.07 11.59 9 123505 151 29450862
Embolism 15.05 11.59 5 123509 6891 29444122
Poor quality sleep 15.02 11.59 65 123449 7168 29443845
Metastases to lung 15.00 11.59 7 123507 7848 29443165
Nephrogenic diabetes insipidus 14.94 11.59 21 123493 1118 29449895
Cardiac failure acute 14.94 11.59 10 123504 9182 29441831
Oral mucosa erosion 14.93 11.59 18 123496 823 29450190
Abnormal palmar/plantar creases 14.92 11.59 10 123504 207 29450806
Wound 14.92 11.59 17 123497 12046 29438967
Reproductive tract hypoplasia, male 14.86 11.59 5 123509 18 29450995
Adverse drug reaction 14.83 11.59 51 123463 23969 29427044
Contraindicated product administered 14.82 11.59 34 123480 18232 29432781
Muscle contracture 14.74 11.59 21 123493 1132 29449881
Camptocormia 14.72 11.59 9 123505 158 29450855
Mouth breathing 14.71 11.59 7 123507 72 29450941
Enteritis 14.69 11.59 5 123509 6786 29444227
Clonic convulsion 14.67 11.59 15 123499 570 29450443
Acute pulmonary oedema 14.65 11.59 5 123509 6774 29444239
Heart rate irregular 14.63 11.59 20 123494 13097 29437916
Use of accessory respiratory muscles 14.61 11.59 12 123502 342 29450671
Screaming 14.60 11.59 22 123492 1248 29449765
Hypomagnesaemia 14.59 11.59 32 123482 17436 29433577
Wrist deformity 14.55 11.59 12 123502 344 29450669
Haematoma 14.52 11.59 49 123465 23163 29427850
Hyperthyroidism 14.49 11.59 9 123505 8599 29442414
Feminisation acquired 14.47 11.59 6 123508 43 29450970
Ischaemic stroke 14.42 11.59 28 123486 15949 29435064
Echopraxia 14.29 11.59 4 123510 6 29451007
Intestinal perforation 14.25 11.59 8 123506 8078 29442935
Gender dysphoria 14.24 11.59 6 123508 45 29450968
Hepatic cirrhosis 14.21 11.59 24 123490 14420 29436593
Suspected suicide attempt 14.18 11.59 8 123506 120 29450893
Fungal infection 14.16 11.59 22 123492 13663 29437350
Hypovolaemia 14.12 11.59 8 123506 8037 29442976
Gingival atrophy 14.02 11.59 6 123508 47 29450966
Adenoidal hypertrophy 14.01 11.59 8 123506 123 29450890
Dysphagia 14.01 11.59 314 123200 54612 29396401
Feeding disorder 13.98 11.59 55 123459 5812 29445201
Pulmonary thrombosis 13.91 11.59 5 123509 6560 29444453
Hepatitis B 13.85 11.59 3 123511 5494 29445519
Frontotemporal dementia 13.82 11.59 10 123504 235 29450778
Anxiety disorder 13.77 11.59 24 123490 1540 29449473
Drug ineffective for unapproved indication 13.69 11.59 104 123410 14110 29436903
Pulmonary valve incompetence 13.63 11.59 16 123498 711 29450302
Tympanic membrane disorder 13.60 11.59 6 123508 51 29450962
SJS-TEN overlap 13.57 11.59 10 123504 242 29450771
Sinus disorder 13.56 11.59 4 123510 5951 29445062
Coprolalia 13.56 11.59 5 123509 25 29450988
Small intestinal obstruction 13.51 11.59 21 123493 13040 29437973
Electrocardiogram QT prolonged 13.48 11.59 219 123295 35918 29415095
Sudden death 13.45 11.59 103 123411 14007 29437006
Acquired epileptic aphasia 13.45 11.59 3 123511 0 29451013
Mentally late developer 13.45 11.59 3 123511 0 29451013
Congenital tongue anomaly 13.45 11.59 3 123511 0 29451013
Renal fusion anomaly 13.45 11.59 3 123511 0 29451013
Deformity of orbit 13.45 11.59 3 123511 0 29451013
Dacryoadenitis acquired 13.45 11.59 3 123511 0 29451013
Hypocarnitinaemia 13.45 11.59 3 123511 0 29451013
Blindness congenital 13.45 11.59 3 123511 0 29451013
Anuria 13.45 11.59 12 123502 9529 29441484
Neonatal hypoacusis 13.45 11.59 3 123511 0 29451013
Cerebral cyst 13.43 11.59 10 123504 246 29450767
Limb asymmetry 13.42 11.59 7 123507 89 29450924
Cardiac murmur 13.41 11.59 59 123455 6554 29444459
Device issue 13.28 11.59 8 123506 7772 29443241
Haemorrhagic stroke 13.22 11.59 4 123510 5852 29445161
Mastication disorder 13.20 11.59 20 123494 1140 29449873
Injection site pruritus 13.19 11.59 4 123510 5845 29445168
Cytopenia 13.19 11.59 13 123501 9846 29441167
Agitation neonatal 13.16 11.59 19 123495 1037 29449976
Drug level fluctuating 13.15 11.59 13 123501 474 29450539
Wheezing 13.14 11.59 83 123431 33157 29417856
Accidental death 13.11 11.59 28 123486 2090 29448923
Nephrotic syndrome 13.11 11.59 5 123509 6323 29444690
CSF white blood cell count positive 13.09 11.59 5 123509 28 29450985
Cytomegalovirus viraemia 13.08 11.59 5 123509 6315 29444698
Snoring 13.05 11.59 33 123481 2751 29448262
Gastritis 13.04 11.59 40 123474 19477 29431536
Terminal insomnia 13.03 11.59 12 123502 400 29450613
Hand-eye coordination impaired 13.03 11.59 6 123508 57 29450956
Wrong schedule 12.86 11.59 8 123506 145 29450868
Elbow deformity 12.81 11.59 5 123509 30 29450983
Blood alkaline phosphatase increased 12.80 11.59 68 123446 28338 29422675
Necrotising enterocolitis neonatal 12.80 11.59 9 123505 202 29450811
Macrocephaly 12.76 11.59 12 123502 411 29450602
Haematotoxicity 12.74 11.59 6 123508 6693 29444320
Hip fracture 12.74 11.59 15 123499 10477 29440536
Hypercalcaemia 12.74 11.59 21 123493 12738 29438275
Diabetic coma 12.72 11.59 16 123498 764 29450249
Pancreatic carcinoma 12.71 11.59 7 123507 7143 29443870
Mixed delusion 12.69 11.59 4 123510 11 29451002
Haemorrhage intracranial 12.68 11.59 26 123488 14516 29436497
Skin disorder 12.68 11.59 18 123496 11600 29439413
Wrong technique in product usage process 12.67 11.59 78 123436 31350 29419663
Gallbladder disorder 12.67 11.59 4 123510 5696 29445317
Disseminated intravascular coagulation 12.62 11.59 42 123472 19938 29431075
Mass 12.58 11.59 7 123507 7104 29443909
Base excess increased 12.54 11.59 5 123509 32 29450981
Cholangitis 12.52 11.59 8 123506 7529 29443484
Poisoning 12.52 11.59 78 123436 9915 29441098
Therapy interrupted 12.49 11.59 10 123504 8376 29442637
Bronchospasm 12.48 11.59 13 123501 9596 29441417
Ischaemic cardiomyopathy 12.46 11.59 4 123510 5634 29445379
Pulmonary eosinophilia 12.46 11.59 9 123505 211 29450802
Skin lesion 12.46 11.59 38 123476 18534 29432479
Locomotive syndrome 12.44 11.59 4 123510 12 29451001
Monorchidism 12.44 11.59 4 123510 12 29451001
Seasonal allergy 12.43 11.59 3 123511 5099 29445914
Nocturia 12.42 11.59 10 123504 8352 29442661
Illusion 12.42 11.59 15 123499 687 29450326
Post-acute COVID-19 syndrome 12.41 11.59 5 123509 33 29450980
Laryngitis 12.39 11.59 27 123487 2044 29448969
Urosepsis 12.38 11.59 16 123498 10730 29440283
Bronchiectasis 12.37 11.59 6 123508 6579 29444434
Renal cyst 12.33 11.59 9 123505 7898 29443115
Drug withdrawal syndrome 12.30 11.59 122 123392 17862 29433151
Respiratory fatigue 12.26 11.59 6 123508 66 29450947
Progressive multifocal leukoencephalopathy 12.25 11.59 11 123503 8708 29442305
Feeling of despair 12.10 11.59 17 123497 905 29450108
Spinal fracture 12.05 11.59 6 123508 6480 29444533
Cytotoxic oedema 12.04 11.59 8 123506 163 29450850
Neurotoxicity 12.02 11.59 27 123487 14586 29436427
Polydipsia psychogenic 12.01 11.59 7 123507 112 29450901
Heparin-induced thrombocytopenia 11.99 11.59 3 123511 4976 29446037
Hypotony maculopathy 11.97 11.59 4 123510 14 29450999
Back disorder 11.91 11.59 5 123509 5968 29445045
Burning sensation 11.88 11.59 31 123483 15907 29435106
Anticoagulation drug level decreased 11.88 11.59 6 123508 71 29450942
Posterior reversible encephalopathy syndrome 11.84 11.59 71 123443 8905 29442108
Coronary artery stenosis 11.83 11.59 11 123503 8562 29442451
Congenital multiplex arthrogryposis 11.81 11.59 5 123509 38 29450975
Pica 11.76 11.59 4 123510 15 29450998
Cardiovascular disorder 11.70 11.59 12 123502 8923 29442090
Blunted affect 11.68 11.59 10 123504 302 29450711
Anodontia 11.66 11.59 6 123508 74 29450939
Mitochondrial cytopathy 11.63 11.59 8 123506 173 29450840

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2362.85 10.74 2628 180311 164264 64151529
Hyperammonaemia 2257.37 10.74 902 182037 9002 64306791
Drug interaction 1945.57 10.74 3588 179351 358495 63957298
Hyperammonaemic encephalopathy 1804.50 10.74 605 182334 3453 64312340
Status epilepticus 1219.38 10.74 762 182177 20901 64294892
Aggression 1120.22 10.74 978 181961 45254 64270539
Neuroleptic malignant syndrome 1088.94 10.74 749 182190 24247 64291546
Somnolence 1054.73 10.74 1990 180949 201655 64114138
Sopor 859.81 10.74 696 182243 28965 64286828
Epilepsy 827.57 10.74 717 182222 32814 64282979
Extrapyramidal disorder 715.67 10.74 527 182412 19025 64296768
Generalised tonic-clonic seizure 695.77 10.74 703 182236 39154 64276639
Ammonia increased 692.87 10.74 356 182583 6621 64309172
Granulocytopenia 686.99 10.74 406 182533 10034 64305759
Psychotic disorder 670.65 10.74 646 182293 33932 64281861
Arthralgia 613.71 10.74 244 182695 442016 63873777
Parkinsonism 612.47 10.74 425 182514 13948 64301845
Mania 607.40 10.74 444 182495 15842 64299951
Toxicity to various agents 596.32 10.74 2319 180620 361194 63954599
Coma 595.46 10.74 966 181973 86649 64229144
Intentional overdose 592.79 10.74 978 181961 88966 64226827
Agitation 578.54 10.74 958 181981 87409 64228384
Dyspnoea 551.18 10.74 742 182197 717932 63597861
Overdose 540.10 10.74 1313 181626 158253 64157540
Pain 509.09 10.74 493 182446 553018 63762775
Intentional self-injury 488.12 10.74 502 182437 28542 64287251
Multiple-drug resistance 484.01 10.74 274 182665 6228 64309565
Abnormal behaviour 476.65 10.74 531 182408 33091 64282702
Petit mal epilepsy 465.94 10.74 245 182694 4787 64311006
Sedation 463.72 10.74 580 182359 40882 64274911
Drug level increased 442.29 10.74 515 182424 33681 64282112
Diarrhoea 432.90 10.74 876 182063 721828 63593965
Tremor 417.01 10.74 1138 181801 147092 64168701
Ataxia 410.17 10.74 403 182536 21681 64294112
Depressed level of consciousness 404.71 10.74 783 182156 80653 64235140
Rheumatoid arthritis 403.48 10.74 14 182925 164280 64151513
Salivary hypersecretion 395.53 10.74 305 182634 11808 64303985
Joint swelling 387.88 10.74 71 182868 215311 64100482
Suicide attempt 380.40 10.74 705 182234 70302 64245491
Drug reaction with eosinophilia and systemic symptoms 379.39 10.74 606 182333 53611 64262182
Cognitive disorder 364.09 10.74 600 182339 54487 64261306
Fatigue 356.06 10.74 1024 181915 747706 63568087
Irritability 344.01 10.74 471 182468 36275 64279518
Anticonvulsant drug level increased 340.88 10.74 156 182783 2221 64313572
Infusion related reaction 328.73 10.74 40 182899 164427 64151366
Drug level decreased 320.75 10.74 264 182675 11239 64304554
Nausea 315.73 10.74 1158 181781 784642 63531151
Blood creatine phosphokinase increased 313.10 10.74 581 182358 57977 64257816
Peripheral swelling 305.33 10.74 106 182833 209047 64106746
Foetal anticonvulsant syndrome 303.36 10.74 80 182859 156 64315637
Catatonia 302.95 10.74 216 182723 7404 64308389
Encephalopathy 301.31 10.74 573 182366 58246 64257547
Delusion 300.18 10.74 310 182629 17704 64298089
Antipsychotic drug level increased 297.99 10.74 184 182755 4931 64310862
Schizophrenia 294.16 10.74 248 182691 10920 64304873
Pain in extremity 292.12 10.74 258 182681 302827 64012966
Hallucination, auditory 283.16 10.74 292 182647 16647 64299146
Altered state of consciousness 280.85 10.74 435 182504 37467 64278326
Electroencephalogram abnormal 275.09 10.74 176 182763 5027 64310766
Hypernatraemia 271.42 10.74 246 182693 11943 64303850
Drug abuse 270.09 10.74 908 182031 131466 64184327
Anticonvulsant drug level decreased 268.41 10.74 122 182817 1708 64314085
Febrile neutropenia 267.25 10.74 99 182840 187558 64128235
Muscle rigidity 266.78 10.74 287 182652 17186 64298607
Synovitis 264.64 10.74 3 182936 99087 64216706
Arthropathy 260.95 10.74 22 182917 120945 64194848
Psychomotor hyperactivity 257.76 10.74 258 182681 14193 64301600
Treatment noncompliance 254.80 10.74 449 182490 43033 64272760
Partial seizures 254.00 10.74 191 182748 7116 64308677
Fanconi syndrome 243.65 10.74 126 182813 2375 64313418
Dysmorphism 241.97 10.74 81 182858 459 64315334
Myoclonic epilepsy 241.54 10.74 109 182830 1499 64314294
Pneumonia aspiration 237.90 10.74 522 182417 58749 64257044
Sudden unexplained death in epilepsy 230.37 10.74 81 182858 544 64315249
Delirium 228.00 10.74 564 182375 68630 64247163
Hypothermia 227.12 10.74 281 182658 19575 64296218
Sinusitis 227.06 10.74 66 182873 145862 64169931
Anticonvulsant drug level above therapeutic 224.87 10.74 91 182848 939 64314854
Disorientation 222.16 10.74 490 182449 55338 64260455
Tardive dyskinesia 215.76 10.74 191 182748 8987 64306806
Nasopharyngitis 213.99 10.74 147 182792 195926 64119867
Swelling 212.67 10.74 94 182845 160124 64155669
Completed suicide 212.49 10.74 1222 181717 223192 64092601
Bradyphrenia 211.72 10.74 191 182748 9215 64306578
Cough 210.91 10.74 332 182607 301816 64013977
Abdominal discomfort 210.82 10.74 128 182811 182194 64133599
Drug withdrawal convulsions 209.58 10.74 108 182831 2020 64313773
Disturbance in attention 207.69 10.74 398 182541 40676 64275117
Suicidal ideation 203.20 10.74 527 182412 66015 64249778
Headache 199.91 10.74 799 182140 528668 63787125
Dysarthria 198.66 10.74 487 182452 58919 64256874
Intellectual disability 192.58 10.74 81 182858 929 64314864
Hypersensitivity 191.82 10.74 165 182774 196287 64119506
Depression 190.73 10.74 1024 181915 182267 64133526
Dystonia 190.57 10.74 251 182688 18614 64297179
Foetal exposure during pregnancy 185.15 10.74 130 182809 4346 64311447
Myoclonus 184.27 10.74 287 182652 24831 64290962
Back pain 184.10 10.74 265 182674 249906 64065887
Anaemia 182.86 10.74 513 182426 378167 63937626
Cardiac failure congestive 182.33 10.74 71 182868 130509 64185284
Psychomotor retardation 182.25 10.74 136 182803 5007 64310786
Akathisia 180.90 10.74 192 182747 11318 64304475
Mental impairment 178.48 10.74 226 182713 16117 64299676
Anticonvulsant drug level below therapeutic 178.29 10.74 77 182862 947 64314846
Stevens-Johnson syndrome 178.26 10.74 336 182603 33913 64281880
Confusional state 177.97 10.74 1309 181630 259835 64055958
Pruritus 177.52 10.74 389 182550 312011 64003782
Dyskinesia 173.13 10.74 360 182579 39028 64276765
Speech disorder 170.41 10.74 405 182534 48036 64267757
Chest pain 169.68 10.74 254 182685 235726 64080067
Bipolar disorder 169.59 10.74 146 182793 6615 64309178
Psychogenic seizure 165.80 10.74 88 182851 1753 64314040
Hepatic function abnormal 163.20 10.74 476 182463 63837 64251956
Psychomotor skills impaired 157.48 10.74 111 182828 3734 64312059
Mental disorder 156.10 10.74 274 182665 26171 64289622
Paranoia 155.12 10.74 211 182728 16141 64299652
Atrial fibrillation 154.81 10.74 154 182785 170935 64144858
Neuropathy peripheral 154.28 10.74 70 182869 117455 64198338
Drug ineffective 153.71 10.74 3282 179657 836965 63478828
Paradoxical drug reaction 153.19 10.74 132 182807 5988 64309805
Myocarditis 152.79 10.74 214 182725 16829 64298964
Stupor 152.75 10.74 131 182808 5904 64309889
Hypomania 151.87 10.74 127 182812 5527 64310266
Focal dyscognitive seizures 151.30 10.74 102 182837 3188 64312605
Contraindicated product administered 149.92 10.74 59 182880 107770 64208023
Toxic encephalopathy 147.69 10.74 160 182779 9655 64306138
Gastrointestinal haemorrhage 147.25 10.74 97 182842 132215 64183578
Restlessness 144.69 10.74 337 182602 39448 64276345
Myocardial infarction 144.66 10.74 154 182785 165667 64150126
Drug intolerance 144.39 10.74 193 182746 187799 64127994
Nystagmus 143.81 10.74 152 182787 8916 64306877
Developmental delay 142.27 10.74 66 182873 971 64314822
Drug ineffective for unapproved indication 142.07 10.74 289 182650 30844 64284949
Speech disorder developmental 141.65 10.74 55 182884 504 64315289
Autism spectrum disorder 138.85 10.74 63 182876 878 64314915
Injection site pain 137.66 10.74 72 182867 111336 64204457
Arthritis 135.78 10.74 35 182904 83779 64232014
Persecutory delusion 134.21 10.74 104 182835 4054 64311739
Abdominal pain upper 134.10 10.74 180 182759 174850 64140943
Drug resistance 130.58 10.74 300 182639 34802 64280991
Brain oedema 129.35 10.74 228 182711 21847 64293946
Oculogyric crisis 127.15 10.74 83 182856 2455 64313338
Eosinophilia 127.11 10.74 312 182627 37764 64278029
Schizoaffective disorder 126.60 10.74 70 182869 1517 64314276
Leukopenia 125.90 10.74 595 182344 100647 64215146
Behaviour disorder 125.63 10.74 103 182836 4359 64311434
Wrong patient received product 125.59 10.74 96 182843 3666 64312127
Systemic lupus erythematosus 124.60 10.74 33 182906 77579 64238214
Electrocardiogram QT prolonged 124.05 10.74 500 182439 78948 64236845
Acute kidney injury 121.15 10.74 762 182177 448478 63867315
Thrombocytopenia 119.83 10.74 1062 181877 222739 64093054
Blood pressure increased 118.94 10.74 191 182748 172361 64143432
Priapism 118.88 10.74 95 182844 3875 64311918
Interstitial lung disease 118.05 10.74 65 182874 97667 64218126
Mental status changes 116.28 10.74 410 182529 60752 64255041
Herpes zoster 115.68 10.74 40 182899 79147 64236646
Malignant neoplasm progression 113.56 10.74 92 182847 112779 64203014
Asterixis 112.84 10.74 75 182864 2288 64313505
Glossodynia 112.81 10.74 23 182916 64673 64251120
Rhabdomyolysis 111.81 10.74 536 182403 91190 64224603
Disease progression 111.28 10.74 143 182796 141537 64174256
Urticaria 110.32 10.74 154 182785 147163 64168630
Injection site erythema 110.12 10.74 32 182907 70768 64245025
Cerebral atrophy 110.03 10.74 119 182820 7166 64308627
Dyspnoea exertional 109.87 10.74 36 182903 73694 64242099
Affect lability 107.29 10.74 130 182809 8860 64306933
Abdominal pain 106.20 10.74 490 182449 311885 64003908
Carnitine deficiency 104.27 10.74 34 182905 175 64315618
Bradykinesia 104.10 10.74 110 182829 6450 64309343
Drug level below therapeutic 103.53 10.74 116 182823 7268 64308525
Discomfort 103.31 10.74 50 182889 80828 64234965
Influenza 103.28 10.74 90 182849 106441 64209352
Lethargy 103.24 10.74 444 182495 72150 64243643
Eosinophilic pleural effusion 102.99 10.74 36 182903 237 64315556
Atonic seizures 102.82 10.74 46 182893 619 64315174
Psychiatric symptom 102.78 10.74 107 182832 6166 64309627
Hyperprolactinaemia 102.40 10.74 88 182851 3977 64311816
Death 101.70 10.74 878 182061 481827 63833966
Learning disorder 101.48 10.74 43 182896 503 64315290
Antipsychotic drug level above therapeutic 100.99 10.74 64 182875 1797 64313996
Impaired healing 100.38 10.74 24 182915 60449 64255344
Fluid retention 100.24 10.74 23 182916 59583 64256210
Chest discomfort 99.93 10.74 109 182830 115997 64199796
Antipsychotic drug level below therapeutic 99.93 10.74 51 182888 934 64314859
Myalgia 99.79 10.74 186 182753 158431 64157362
Osteoarthritis 99.66 10.74 28 182911 63308 64252485
Thrombosis 99.26 10.74 38 182901 70604 64245189
Hypoaesthesia 98.69 10.74 151 182788 138957 64176836
Acidosis hyperchloraemic 97.92 10.74 45 182894 647 64315146
Neutrophil count increased 97.91 10.74 219 182720 24955 64290838
Tonic convulsion 97.88 10.74 63 182876 1818 64313975
Hypotonia 97.86 10.74 139 182800 11073 64304720
Asthenia 97.70 10.74 762 182177 427282 63888511
Impulsive behaviour 95.66 10.74 71 182868 2592 64313201
Wound 95.09 10.74 49 182890 76428 64239365
Plasma cell myeloma 95.02 10.74 10 182929 46065 64269728
Thinking abnormal 94.63 10.74 139 182800 11417 64304376
Pleurothotonus 93.22 10.74 66 182873 2236 64313557
Stomatitis 93.11 10.74 104 182835 109501 64206292
Seizure cluster 92.89 10.74 36 182903 328 64315465
White blood cell count increased 92.52 10.74 402 182537 65612 64250181
Bipolar I disorder 88.92 10.74 58 182881 1713 64314080
Blood prolactin increased 88.11 10.74 76 182863 3452 64312341
Hypertonia 88.06 10.74 99 182840 6226 64309567
Product residue present 87.45 10.74 73 182866 3169 64312624
Dysphoria 86.95 10.74 83 182856 4305 64311488
Cerebellar atrophy 84.90 10.74 47 182892 1021 64314772
Metabolic acidosis 83.12 10.74 410 182529 70548 64245245
Musculoskeletal pain 82.09 10.74 66 182873 81228 64234565
Malaise 81.94 10.74 724 182215 395523 63920270
Duodenal ulcer perforation 81.43 10.74 4 182935 34621 64281172
Euphoric mood 79.78 10.74 96 182843 6495 64309298
Oppositional defiant disorder 79.59 10.74 35 182904 451 64315342
Mucosal inflammation 79.46 10.74 39 182900 62545 64253248
Bronchitis 79.09 10.74 116 182823 108627 64207166
Psychotic symptom 79.04 10.74 58 182881 2080 64313713
Loss of consciousness 78.79 10.74 703 182236 147662 64168131
Toxic epidermal necrolysis 78.40 10.74 258 182681 36908 64278885
Psoriatic arthropathy 78.40 10.74 14 182925 43267 64272526
Differential white blood cell count abnormal 78.21 10.74 54 182885 1756 64314037
Coordination abnormal 78.09 10.74 147 182792 14817 64300976
Pancreatitis acute 77.79 10.74 283 182656 42572 64273221
Helicobacter infection 77.40 10.74 9 182930 38353 64277440
Drug hypersensitivity 77.28 10.74 379 182560 237436 64078357
Product substitution issue 77.01 10.74 162 182777 17699 64298094
Pneumonia 76.60 10.74 1122 181817 558454 63757339
Anger 76.46 10.74 150 182789 15591 64300202
Epistaxis 76.05 10.74 100 182839 98031 64217762
Infantile spasms 75.83 10.74 29 182910 254 64315539
Chills 75.32 10.74 174 182765 137090 64178703
Rash 74.97 10.74 886 182053 457663 63858130
Cardiac failure 74.91 10.74 165 182774 132208 64183585
Flushing 74.35 10.74 68 182871 78580 64237213
Cerebrovascular accident 74.22 10.74 176 182763 137407 64178386
Gaze palsy 74.19 10.74 60 182879 2490 64313303
Psoriasis 73.93 10.74 57 182882 71646 64244147
Rhinorrhoea 73.70 10.74 39 182900 59930 64255863
Therapeutic product effect decreased 73.66 10.74 134 182805 115217 64200576
Drooling 73.62 10.74 83 182856 5236 64310557
Injection site pruritus 73.58 10.74 10 182929 37816 64277977
Antipsychotic drug level decreased 73.56 10.74 41 182898 903 64314890
Muscle spasms 73.24 10.74 184 182755 140839 64174954
Dysmetria 72.79 10.74 40 182899 856 64314937
Delusion of grandeur 72.53 10.74 35 182904 565 64315228
Gait disturbance 72.00 10.74 776 182163 171379 64144414
Renal failure 71.62 10.74 269 182670 181419 64134374
Inappropriate antidiuretic hormone secretion 71.60 10.74 180 182759 22109 64293684
Communication disorder 71.35 10.74 69 182870 3637 64312156
Injection site reaction 70.91 10.74 22 182917 46642 64269151
Haematochezia 70.70 10.74 51 182888 66322 64249471
Poisoning 70.61 10.74 177 182762 21702 64294091
Anaphylactic reaction 70.27 10.74 55 182884 68609 64247184
Apathy 69.70 10.74 119 182820 11113 64304680
Injection site swelling 69.45 10.74 16 182923 41337 64274456
Hyponatraemia 68.83 10.74 683 182256 147656 64168137
Blood lactic acid increased 68.28 10.74 113 182826 10288 64305505
Neutropenia 68.06 10.74 1005 181934 238619 64077174
Paraesthesia 67.94 10.74 178 182761 134344 64181449
Logorrhoea 67.88 10.74 70 182869 3989 64311804
Respiratory depression 67.79 10.74 182 182757 23261 64292532
Contusion 67.03 10.74 139 182800 113826 64201967
Propofol infusion syndrome 66.96 10.74 47 182892 1570 64314223
Acute hepatic failure 66.92 10.74 194 182745 25918 64289875
Oedema peripheral 66.70 10.74 338 182601 209979 64105814
Cogwheel rigidity 66.31 10.74 59 182880 2794 64312999
Acute myocardial infarction 66.24 10.74 60 182879 69658 64246135
Erythema 66.16 10.74 289 182650 186781 64129012
Hyperkinesia 65.93 10.74 56 182883 2490 64313303
Carnitine decreased 65.44 10.74 14 182925 3 64315790
Homicidal ideation 65.28 10.74 62 182877 3195 64312598
Tonic clonic movements 64.74 10.74 50 182889 1939 64313854
Hot flush 64.73 10.74 25 182914 46210 64269583
Decreased eye contact 64.50 10.74 35 182904 730 64315063
Hyperlactacidaemia 64.35 10.74 74 182865 4770 64311023
Hallucination 63.98 10.74 389 182550 72399 64243394
Attention deficit hyperactivity disorder 63.82 10.74 57 182882 2713 64313080
Tachycardia 63.35 10.74 676 182263 148903 64166890
Infection 63.35 10.74 289 182650 184591 64131202
Urinary tract infection 63.23 10.74 391 182548 231205 64084588
Resting tremor 63.02 10.74 43 182896 1371 64314422
Unresponsive to stimuli 62.48 10.74 296 182643 50097 64265696
Coronary artery disease 62.35 10.74 48 182891 60385 64255408
Alopecia 62.29 10.74 250 182689 165440 64150353
Hallucination, visual 62.13 10.74 197 182742 27637 64288156
Intentional product use issue 61.58 10.74 110 182829 95254 64220539
Necrosis ischaemic 61.46 10.74 37 182902 946 64314847
Psychiatric decompensation 61.39 10.74 53 182886 2410 64313383
Pancreatitis 60.52 10.74 331 182608 59276 64256517
Urinary incontinence 60.02 10.74 232 182707 35919 64279874
Drug level changed 60.00 10.74 29 182910 470 64315323
Prescribed overdose 59.96 10.74 159 182780 20172 64295621
Enuresis 59.55 10.74 55 182884 2735 64313058
Grandiosity 59.49 10.74 30 182909 535 64315258
Depressed mood 59.18 10.74 252 182687 40760 64275033
Inflammation 58.76 10.74 59 182880 65241 64250552
Bone pain 58.37 10.74 31 182908 47541 64268252
Gingival hypertrophy 58.34 10.74 54 182885 2693 64313100
Nasal congestion 58.29 10.74 50 182889 59608 64256185
Pressure of speech 58.28 10.74 36 182903 965 64314828
Blood pressure systolic increased 58.11 10.74 34 182905 49419 64266374
Chorea 58.06 10.74 47 182892 1953 64313840
Knee arthroplasty 57.95 10.74 5 182934 26994 64288799
Hyperthermia 57.93 10.74 133 182806 15417 64300376
Neoplasm progression 57.60 10.74 22 182917 40942 64274851
Metabolic encephalopathy 56.50 10.74 90 182849 7935 64307858
Throat irritation 56.25 10.74 12 182927 32699 64283094
Folliculitis 56.08 10.74 9 182930 30068 64285725
Obesity 55.84 10.74 156 182783 20406 64295387
Retinogram abnormal 55.65 10.74 24 182915 294 64315499
Mood altered 55.53 10.74 133 182806 15846 64299947
Craniosynostosis 55.40 10.74 17 182922 69 64315724
Gastrointestinal disorder 54.81 10.74 107 182832 89602 64226191
Learning disability 54.71 10.74 21 182918 186 64315607
Haemoptysis 54.48 10.74 36 182903 49012 64266781
Oropharyngeal pain 54.30 10.74 106 182833 88761 64227032
Congenital hand malformation 53.55 10.74 11 182928 0 64315793
Mitochondrial DNA mutation 53.52 10.74 22 182917 237 64315556
C-reactive protein abnormal 53.47 10.74 9 182930 29038 64286755
Disinhibition 53.36 10.74 47 182892 2196 64313597
Serotonin syndrome 53.34 10.74 237 182702 39045 64276748
Hyperkalaemia 53.24 10.74 131 182808 100998 64214795
Obsessive-compulsive disorder 53.19 10.74 67 182872 4751 64311042
Dehydration 53.10 10.74 378 182561 216385 64099408
Hyperosmolar state 53.05 10.74 29 182910 614 64315179
Autonomic nervous system imbalance 53.01 10.74 62 182877 4070 64311723
Mydriasis 52.73 10.74 127 182812 15185 64300608
Pain in jaw 52.34 10.74 25 182914 40730 64275063
Dry skin 52.32 10.74 41 182898 51120 64264673
Gastrooesophageal reflux disease 51.82 10.74 98 182841 83045 64232748
Osteonecrosis of jaw 51.80 10.74 24 182915 39801 64275992
Dysgeusia 51.63 10.74 35 182904 47012 64268781
Partial seizures with secondary generalisation 51.44 10.74 26 182913 466 64315327
Muscle injury 51.40 10.74 7 182932 26430 64289363
Ascites 51.37 10.74 60 182879 61941 64253852
Intestinal ischaemia 51.25 10.74 106 182833 11443 64304350
Hypokinesia 51.20 10.74 132 182807 16464 64299329
Pulmonary arterial hypertension 51.06 10.74 6 182933 25361 64290432
Conjunctival hyperaemia 50.85 10.74 59 182880 3840 64311953
Hypertension 50.78 10.74 480 182459 258781 64057012
Pneumonitis 50.70 10.74 41 182898 50324 64265469
Physical assault 50.62 10.74 39 182900 1507 64314286
Injection site bruising 50.37 10.74 20 182919 36353 64279440
Product dose omission issue 49.97 10.74 335 182604 194412 64121381
Encephalitis autoimmune 49.94 10.74 42 182897 1842 64313951
General physical health deterioration 49.82 10.74 357 182582 204068 64111725
Blood pressure fluctuation 48.84 10.74 45 182894 51826 64263967
Posture abnormal 48.60 10.74 54 182885 3352 64312441
Diabetes insipidus 48.54 10.74 62 182877 4459 64311334
Choreoathetosis 48.47 10.74 37 182902 1410 64314383
Postictal state 48.31 10.74 39 182900 1614 64314179
Weight decreased 48.20 10.74 548 182391 285191 64030602
Heart rate decreased 48.14 10.74 51 182888 55016 64260777
Drop attacks 47.95 10.74 32 182907 983 64314810
Sluggishness 47.58 10.74 69 182870 5601 64310192
Language disorder 47.51 10.74 48 182891 2669 64313124
Feeling hot 47.45 10.74 36 182903 45627 64270166
Rectal haemorrhage 46.87 10.74 64 182875 61753 64254040
Sexually inappropriate behaviour 46.81 10.74 24 182915 444 64315349
Weight increased 46.19 10.74 856 182083 212492 64103301
Diverticulitis 46.16 10.74 26 182913 38592 64277201
Hyperglycinaemia 46.07 10.74 10 182929 3 64315790
Basal cell carcinoma 46.03 10.74 15 182924 30823 64284970
Nephrogenic diabetes insipidus 45.81 10.74 40 182899 1847 64313946
Drug withdrawal syndrome 45.71 10.74 193 182746 31098 64284695
Depressive symptom 45.68 10.74 60 182879 4436 64311357
Miosis 45.65 10.74 110 182829 13156 64302637
Leukocytosis 45.57 10.74 220 182719 37520 64278273
Neovascularisation 45.54 10.74 32 182907 1071 64314722
Cataract 45.34 10.74 47 182892 51215 64264578
Night sweats 44.94 10.74 23 182916 36023 64279770
COVID-19 44.94 10.74 72 182867 65068 64250725
Palmar-plantar erythrodysaesthesia syndrome 44.85 10.74 13 182926 28806 64286987
Staring 44.77 10.74 44 182895 2366 64313427
Intra-abdominal pressure increased 44.41 10.74 19 182920 228 64315565
Angiofibroma 44.34 10.74 16 182923 117 64315676
Educational problem 44.15 10.74 22 182917 382 64315411
Pneumocystis jirovecii pneumonia 43.87 10.74 12 182927 27622 64288171
Renal tubular acidosis 43.84 10.74 48 182891 2931 64312862
Palpitations 43.60 10.74 151 182788 104337 64211456
Hypospadias 43.54 10.74 16 182923 124 64315669
Irritable bowel syndrome 43.47 10.74 26 182913 37343 64278450
Suicidal behaviour 43.32 10.74 47 182892 2840 64312953
Upper gastrointestinal haemorrhage 43.13 10.74 23 182916 35197 64280596
Hypervolaemia 42.66 10.74 28 182911 38257 64277536
Pulmonary hypertension 42.33 10.74 36 182903 43103 64272690
Intentional product misuse 42.24 10.74 350 182589 71945 64243848
Melaena 42.06 10.74 54 182885 53494 64262299
Homicide 42.04 10.74 31 182908 1120 64314673
Lung disorder 41.96 10.74 67 182872 60633 64255160
Postictal psychosis 41.85 10.74 16 182923 140 64315653
Delusional disorder, unspecified type 41.76 10.74 26 182913 707 64315086
Cytokine release syndrome 41.74 10.74 5 182934 20824 64294969
Erectile dysfunction 41.63 10.74 103 182836 12524 64303269
Acute myeloid leukaemia 41.63 10.74 13 182926 27450 64288343
Food interaction 41.61 10.74 34 182905 1432 64314361
Anticonvulsant drug level abnormal 41.56 10.74 13 182926 57 64315736
Hallucinations, mixed 41.41 10.74 67 182872 5985 64309808
Agranulocytosis 41.32 10.74 216 182723 38013 64277780
Mutism 41.30 10.74 39 182900 1995 64313798
Postictal paralysis 41.22 10.74 20 182919 327 64315466
Refusal of treatment by patient 41.15 10.74 80 182859 8259 64307534
Rash maculo-papular 41.11 10.74 251 182688 46775 64269018
Automatism 41.07 10.74 16 182923 148 64315645
Oral mucosa erosion 41.07 10.74 36 182903 1671 64314122
Bruxism 40.97 10.74 51 182888 3573 64312220
Negativism 40.90 10.74 26 182913 734 64315059
Cellulitis 40.68 10.74 133 182806 93524 64222269
Change in seizure presentation 40.45 10.74 19 182920 288 64315505
Cytomegalovirus infection 40.38 10.74 28 182911 37171 64278622
Acute coronary syndrome 40.31 10.74 4 182935 19306 64296487
Increased appetite 40.27 10.74 89 182850 10057 64305736
Flight of ideas 39.95 10.74 25 182914 686 64315107
Medication error 39.53 10.74 260 182679 49706 64266087
Sepsis 39.52 10.74 440 182499 229901 64085892
Dysgraphia 39.49 10.74 49 182890 3422 64312371
Perseveration 39.40 10.74 20 182919 362 64315431
Mood swings 39.32 10.74 124 182815 17344 64298449
Brugada syndrome 39.30 10.74 29 182910 1049 64314744
Angina pectoris 39.13 10.74 42 182897 45039 64270754
Coma scale abnormal 38.87 10.74 75 182864 7699 64308094
Drug level above therapeutic 38.78 10.74 70 182869 6831 64308962
Confabulation 38.70 10.74 21 182918 438 64315355
Affective disorder 38.59 10.74 68 182871 6512 64309281
Dementia 38.41 10.74 138 182801 20628 64295165
Dizziness 38.38 10.74 928 182011 429235 63886558
Metastases to bone 38.36 10.74 6 182933 20429 64295364
Aphasia 38.11 10.74 222 182717 40684 64275109
Syncope 38.04 10.74 276 182663 157359 64158434
Social avoidant behaviour 37.58 10.74 55 182884 4502 64311291
Pulmonary embolism 37.41 10.74 252 182687 146104 64169689
Pulmonary fibrosis 37.35 10.74 19 182920 29859 64285934
Hypersexuality 37.22 10.74 32 182907 1447 64314346
Mobility decreased 37.21 10.74 122 182817 85718 64230075
Flatulence 37.21 10.74 28 182911 35638 64280155
Pulmonary mass 37.07 10.74 11 182928 24005 64291788
Bacteraemia 36.93 10.74 15 182924 26896 64288897
Convulsive threshold lowered 36.93 10.74 26 182913 873 64314920
Metastases to liver 36.89 10.74 11 182928 23930 64291863
Breast hyperplasia 36.77 10.74 14 182925 121 64315672
Cystitis 36.77 10.74 40 182899 42635 64273158
Prostate cancer 36.74 10.74 6 182933 19789 64296004
Tic 36.47 10.74 41 182898 2578 64313215
Lennox-Gastaut syndrome 36.39 10.74 16 182923 206 64315587
Soliloquy 36.35 10.74 22 182917 568 64315225
Limbic encephalitis 36.22 10.74 23 182916 648 64315145
Fibromyalgia 36.07 10.74 29 182910 35702 64280091
Head titubation 36.02 10.74 25 182914 820 64314973
Incoherent 36.00 10.74 69 182870 7049 64308744
Gastric disorder 35.85 10.74 19 182920 29178 64286615
Normal pressure hydrocephalus 35.82 10.74 20 182919 442 64315351
Cryptorchism 35.67 10.74 10 182929 27 64315766
Wheezing 35.29 10.74 114 182825 80465 64235328
Aspergillus infection 35.24 10.74 3 182936 16376 64299417
Ill-defined disorder 35.04 10.74 44 182895 44008 64271785
Judgement impaired 34.98 10.74 27 182912 1046 64314747
Bronchopulmonary aspergillosis 34.94 10.74 6 182933 19079 64296714
Skin ulcer 34.90 10.74 44 182895 43930 64271863
Adjustment disorder with mixed anxiety and depressed mood 34.86 10.74 12 182927 75 64315718
Intensive care unit acquired weakness 34.85 10.74 33 182906 1694 64314099
Musculoskeletal stiffness 34.64 10.74 206 182733 123000 64192793
Platelet count decreased 34.60 10.74 668 182271 167043 64148750
Transfusion 34.43 10.74 5 182934 17989 64297804
Limb discomfort 34.39 10.74 17 182922 27158 64288635
Tachyphrenia 34.38 10.74 34 182905 1842 64313951
Echolalia 34.35 10.74 18 182921 349 64315444
Fungal infection 34.33 10.74 28 182911 34223 64281570
Oropharyngeal oedema 34.27 10.74 16 182923 239 64315554
Anaphylactic shock 34.03 10.74 22 182917 30306 64285487
Verbal abuse 33.74 10.74 16 182923 248 64315545
Tumour lysis syndrome 33.70 10.74 7 182932 19433 64296360
Localised infection 33.68 10.74 22 182917 30139 64285654
Withdrawal syndrome 33.62 10.74 144 182795 23348 64292445
Motor developmental delay 33.13 10.74 15 182924 208 64315585
Metabolic syndrome 33.11 10.74 37 182902 2311 64313482
Septic shock 33.08 10.74 170 182769 105267 64210526
Memory impairment 32.94 10.74 380 182559 85302 64230491
Brief psychotic disorder, with postpartum onset 32.75 10.74 9 182930 22 64315771
Microcephaly 32.72 10.74 14 182925 168 64315625
Faeces discoloured 32.70 10.74 16 182923 25713 64290080
Akinesia 32.70 10.74 42 182897 3037 64312756
Inappropriate affect 32.68 10.74 28 182911 1260 64314533
Polydipsia 32.66 10.74 59 182880 5762 64310031
Ileus paralytic 32.48 10.74 73 182866 8342 64307451
Hepatic adenoma 32.47 10.74 16 182923 271 64315522
Transaminases increased 32.27 10.74 227 182712 44367 64271426
Monocyte count increased 32.22 10.74 71 182868 8008 64307785
Tendonitis 31.84 10.74 9 182930 20273 64295520
Sudden death 31.76 10.74 127 182812 19969 64295824
Colitis 31.67 10.74 75 182864 58599 64257194
Thought blocking 31.59 10.74 14 182925 184 64315609
Breast cancer 31.56 10.74 22 182917 29126 64286667
Joint stiffness 31.55 10.74 24 182915 30380 64285413
Constipation 31.54 10.74 459 182480 228878 64086915
Anion gap increased 31.51 10.74 41 182898 3003 64312790
Stereotypy 31.48 10.74 23 182916 819 64314974
Joint range of motion decreased 31.47 10.74 8 182931 19335 64296458
Angiomyolipoma 31.32 10.74 14 182925 188 64315605
Pancreatitis necrotising 31.25 10.74 42 182897 3175 64312618
Excessive eye blinking 31.18 10.74 27 182912 1233 64314560
Bursitis 31.11 10.74 11 182928 21474 64294319
Aura 31.05 10.74 23 182916 837 64314956
Cerebellar syndrome 30.93 10.74 53 182886 4963 64310830
Hip arthroplasty 30.80 10.74 11 182928 21340 64294453
Lower respiratory tract infection 30.56 10.74 151 182788 94463 64221330
Hyperchloraemia 30.54 10.74 24 182915 955 64314838
Mitochondrial cytopathy 30.43 10.74 17 182922 376 64315417
Epileptic psychosis 30.43 10.74 10 182929 53 64315740
Device expulsion 30.30 10.74 11 182928 21125 64294668
Sinus congestion 30.22 10.74 4 182935 15435 64300358
Epidermolysis bullosa 30.17 10.74 14 182925 206 64315587
Porphyria acute 29.98 10.74 21 182918 699 64315094
Kidney infection 29.75 10.74 7 182932 17831 64297962
Schizoaffective disorder bipolar type 29.72 10.74 12 182927 123 64315670
Screaming 29.69 10.74 43 182896 3486 64312307
Borderline personality disorder 29.67 10.74 22 182917 802 64314991
Distractibility 29.64 10.74 20 182919 626 64315167
Rabbit syndrome 29.56 10.74 16 182923 332 64315461
Right ventricular failure 29.41 10.74 12 182927 21459 64294334
Poverty of speech 29.16 10.74 19 182920 560 64315233
Upper respiratory tract infection 29.15 10.74 107 182832 72678 64243115
Hepatic failure 29.12 10.74 262 182677 55132 64260661
Neurodevelopmental disorder 29.04 10.74 9 182930 38 64315755
Clostridium difficile infection 28.89 10.74 36 182903 36127 64279666
Neurological decompensation 28.85 10.74 48 182891 4388 64311405
Suspiciousness 28.81 10.74 19 182920 572 64315221
Choking 28.66 10.74 80 182859 10458 64305335
Product use in unapproved indication 28.53 10.74 679 182260 175939 64139854
Haemorrhage 28.39 10.74 122 182817 79229 64236564
Maternal exposure during pregnancy 28.19 10.74 158 182781 95726 64220067
Ovarian granulosa-theca cell tumour 28.17 10.74 8 182931 23 64315770
Renal impairment 28.13 10.74 246 182693 134771 64181022
Cardiac disorder 28.05 10.74 74 182865 55742 64260051
Apraxia 28.03 10.74 35 182904 2460 64313333
Oligoasthenozoospermia 27.89 10.74 7 182932 10 64315783
Oedema 27.85 10.74 150 182789 91785 64224008
Balance disorder 27.83 10.74 362 182577 83564 64232229
Motor dysfunction 27.71 10.74 83 182856 11290 64304503
Pericarditis 27.69 10.74 88 182851 62428 64253365
Pneumatosis 27.63 10.74 21 182918 795 64314998
Injection site warmth 27.56 10.74 3 182936 13459 64302334
Sneezing 27.47 10.74 5 182934 15246 64300547
Psychotic behaviour 27.40 10.74 23 182916 1006 64314787
Lymphocyte count increased 27.37 10.74 50 182889 4925 64310868
Subileus 27.35 10.74 50 182889 4927 64310866
Surgery 27.13 10.74 24 182915 28189 64287604
Suspected suicide attempt 27.02 10.74 14 182925 265 64315528
Hypertelorism 26.89 10.74 11 182928 117 64315676
Developmental coordination disorder 26.78 10.74 6 182933 3 64315790
Injection site haemorrhage 26.72 10.74 18 182921 24260 64291533
Amenorrhoea 26.68 10.74 58 182881 6481 64309312
Simple partial seizures 26.62 10.74 19 182920 652 64315141
Blood triglycerides increased 26.50 10.74 115 182824 18751 64297042
Incontinence 26.50 10.74 85 182854 11996 64303797
Eosinophil count decreased 26.34 10.74 35 182904 2617 64313176
Systemic inflammatory response syndrome 26.18 10.74 76 182863 10159 64305634
Haemorrhoids 26.14 10.74 18 182921 23983 64291810
Aspiration 26.12 10.74 106 182833 16779 64299014
Device related infection 26.06 10.74 29 182910 30597 64285196
Device issue 26.00 10.74 16 182923 22632 64293161
Presyncope 25.92 10.74 37 182902 35052 64280741
Myoglobinuria 25.91 10.74 22 182917 978 64314815
Hypothyroidism 25.88 10.74 200 182739 40257 64275536
Post-injection delirium sedation syndrome 25.80 10.74 17 182922 511 64315282
Vomiting 25.60 10.74 1290 181649 549827 63765966
Renal fusion anomaly 25.59 10.74 6 182933 5 64315788
Reflexes abnormal 25.58 10.74 20 182919 790 64315003
Heart rate irregular 25.55 10.74 24 182915 27389 64288404
Niemann-Pick disease 25.41 10.74 8 182931 36 64315757
Ulcer 25.36 10.74 17 182922 22973 64292820
Blood osmolarity increased 25.08 10.74 17 182922 536 64315257
Respiratory acidosis 25.04 10.74 73 182866 9782 64306011
Accidental overdose 24.97 10.74 172 182767 33385 64282408
Neoplasm malignant 24.97 10.74 20 182919 24668 64291125
Glycosuria 24.76 10.74 30 182909 2044 64313749
Eye pain 24.73 10.74 32 182907 31593 64284200
Failure to suspend medication 24.69 10.74 15 182924 390 64315403
Injection site rash 24.68 10.74 7 182932 15735 64300058
Second primary malignancy 24.63 10.74 3 182936 12334 64303459
Hirsutism 24.38 10.74 21 182918 952 64314841
Hypotelorism of orbit 24.34 10.74 5 182934 0 64315793
Decreased gait velocity 24.26 10.74 11 182928 153 64315640
Ammonia abnormal 24.20 10.74 11 182928 154 64315639
Self-injurious ideation 24.10 10.74 37 182902 3160 64312633
Blood loss anaemia 24.08 10.74 5 182934 13887 64301906
Angina unstable 24.03 10.74 7 182932 15460 64300333
Blood urine present 23.93 10.74 11 182928 18329 64297464
Rash pruritic 23.91 10.74 83 182856 57321 64258472
Sinus disorder 23.90 10.74 9 182930 16899 64298894
Lactate pyruvate ratio increased 23.82 10.74 9 182930 76 64315717
Productive cough 23.54 10.74 117 182822 73086 64242707
Blood pressure diastolic abnormal 23.54 10.74 3 182936 11914 64303879
Medication overuse headache 23.44 10.74 18 182921 692 64315101
Transplant rejection 23.40 10.74 10 182929 17391 64298402
Candida infection 23.34 10.74 33 182906 31386 64284407
Aminoaciduria 23.26 10.74 12 182927 225 64315568
Gastric ulcer 23.22 10.74 31 182908 30203 64285590
Drug dependence 23.19 10.74 168 182771 33144 64282649
Neuralgia 23.16 10.74 24 182915 26160 64289633
Hernia 23.16 10.74 5 182934 13513 64302280
Brain malformation 23.11 10.74 8 182931 51 64315742
Sarcopenia 23.08 10.74 14 182925 363 64315430
Dyscalculia 22.97 10.74 8 182931 52 64315741
Dissociation 22.91 10.74 35 182904 2976 64312817
Ultrasound ovary abnormal 22.76 10.74 9 182930 87 64315706
Reduced facial expression 22.72 10.74 29 182910 2084 64313709
Clonus 22.72 10.74 52 182887 6015 64309778
Dyspepsia 22.72 10.74 134 182805 80178 64235615
Product administered to patient of inappropriate age 22.53 10.74 44 182895 4557 64311236
Nephrocalcinosis 22.30 10.74 23 182916 1311 64314482
Saccadic eye movement 22.19 10.74 10 182929 137 64315656
Blood osmolarity decreased 22.19 10.74 22 182917 1196 64314597
Lymphangioleiomyomatosis 22.06 10.74 10 182929 139 64315654
Squamous cell carcinoma 22.06 10.74 6 182933 13863 64301930
Crying 22.05 10.74 114 182825 19976 64295817
Dry eye 22.04 10.74 30 182909 28989 64286804
Postural tremor 22.02 10.74 16 182923 565 64315228
Oral candidiasis 22.01 10.74 20 182919 23192 64292601
Microstomia 22.00 10.74 5 182934 3 64315790
Full blood count decreased 21.97 10.74 19 182920 22563 64293230
Blood sodium increased 21.95 10.74 42 182897 4284 64311509
Ageusia 21.92 10.74 6 182933 13807 64301986
Throat tightness 21.91 10.74 20 182919 23140 64292653
Asthma 21.88 10.74 169 182770 95056 64220737
Therapy interrupted 21.85 10.74 15 182924 20021 64295772
Faecaloma 21.84 10.74 69 182870 9659 64306134
Pneumothorax 21.80 10.74 22 182917 24276 64291517
Hiatus hernia 21.69 10.74 15 182924 19942 64295851
Muscle twitching 21.68 10.74 109 182830 18889 64296904
Skin disorder 21.65 10.74 28 182911 27652 64288141
Hyperexplexia 21.63 10.74 7 182932 35 64315758
Hip fracture 21.62 10.74 27 182912 27072 64288721
Asphyxia 21.61 10.74 68 182871 9498 64306295
Metabolic disorder 21.49 10.74 59 182880 7638 64308155
Hyperphagia 21.48 10.74 29 182910 2202 64313591
Dysphonia 21.45 10.74 64 182875 46318 64269475
Chronic kidney disease 21.36 10.74 88 182851 57831 64257962
Frontotemporal dementia 21.16 10.74 15 182924 509 64315284
Galactorrhoea 21.16 10.74 35 182904 3184 64312609
Oral herpes 21.11 10.74 19 182920 22133 64293660
Bladder cancer 21.11 10.74 3 182936 10971 64304822
Gallbladder disorder 21.03 10.74 11 182928 17019 64298774
Irregular sleep phase 21.03 10.74 8 182931 69 64315724
Developmental regression 21.01 10.74 7 182932 39 64315754
IVth nerve disorder 20.94 10.74 6 182933 18 64315775
Necrotising colitis 20.91 10.74 19 182920 925 64314868
Bronchiectasis 20.89 10.74 7 182932 14133 64301660
Intervertebral disc protrusion 20.87 10.74 16 182923 20175 64295618
Condition aggravated 20.79 10.74 1272 181667 371154 63944639
Illogical thinking 20.73 10.74 8 182931 72 64315721
Adrenal insufficiency 20.59 10.74 20 182919 22467 64293326
Urine amphetamine positive 20.54 10.74 8 182931 74 64315719
Hypophosphataemic osteomalacia 20.50 10.74 12 182927 291 64315502
Hypersomnia 20.35 10.74 110 182829 19607 64296186
Angioedema 20.35 10.74 98 182841 61723 64254070
Paraesthesia oral 20.29 10.74 6 182933 13125 64302668
Therapeutic product ineffective for unapproved indication 20.26 10.74 9 182930 119 64315674
Therapeutic response changed 20.24 10.74 19 182920 965 64314828
Movement disorder 20.23 10.74 119 182820 21881 64293912
Hostility 20.21 10.74 28 182911 2179 64313614
Antisocial behaviour 20.20 10.74 15 182924 548 64315245
Cholelithiasis 20.19 10.74 64 182875 45442 64270351
Nodule 20.16 10.74 13 182926 17934 64297859
Hepatic cirrhosis 20.16 10.74 27 182912 26271 64289522
Haemoglobin decreased 20.15 10.74 411 182528 194652 64121141
Gliosis 20.11 10.74 13 182926 378 64315415
Disturbance in social behaviour 20.05 10.74 38 182901 3849 64311944
Monocytosis 19.99 10.74 16 182923 654 64315139
Coagulopathy 19.98 10.74 157 182782 31763 64284030
Sputum discoloured 19.97 10.74 13 182926 17843 64297950
Gamma-glutamyltransferase increased 19.94 10.74 218 182721 48292 64267501
Carpal tunnel syndrome 19.88 10.74 10 182929 15818 64299975
Clostridium difficile colitis 19.82 10.74 29 182910 27194 64288599
Drug monitoring procedure incorrectly performed 19.78 10.74 13 182926 389 64315404
Feeling of despair 19.75 10.74 30 182909 2538 64313255
Gout 19.66 10.74 19 182920 21394 64294399
Febrile bone marrow aplasia 19.62 10.74 4 182935 11251 64304542
Muscular weakness 19.60 10.74 249 182690 127089 64188704
Pancreatic carcinoma 19.57 10.74 3 182936 10370 64305423
Dysphagia 19.55 10.74 418 182521 106394 64209399
Diffuse large B-cell lymphoma 19.54 10.74 3 182936 10358 64305435
Deja vu 19.54 10.74 7 182932 50 64315743
Intelligence test abnormal 19.47 10.74 4 182935 0 64315793
Gaucher's disease 19.47 10.74 4 182935 0 64315793
Hypocarnitinaemia 19.47 10.74 4 182935 0 64315793
Congenital nose malformation 19.47 10.74 4 182935 0 64315793
Alpers disease 19.47 10.74 4 182935 0 64315793
Injection site urticaria 19.43 10.74 4 182935 11177 64304616
Musculoskeletal discomfort 19.39 10.74 11 182928 16266 64299527
Skin cancer 19.39 10.74 5 182934 11969 64303824
Hepatitis C virus test positive 19.38 10.74 12 182927 323 64315470
Colon cancer 19.36 10.74 6 182933 12733 64303060
Anxiety 19.36 10.74 730 182209 201919 64113874
Joint effusion 19.34 10.74 7 182932 13466 64302327
Oral pain 19.33 10.74 30 182909 27463 64288330
Stress 19.32 10.74 97 182842 60437 64255356
Middle insomnia 19.26 10.74 80 182859 12797 64302996
Hereditary ataxia 19.24 10.74 6 182933 26 64315767
Febrile convulsion 19.23 10.74 17 182922 798 64314995
Pectus excavatum 19.22 10.74 5 182934 9 64315784
Anisometropia 19.22 10.74 5 182934 9 64315784
Basilar artery occlusion 19.22 10.74 10 182929 191 64315602
Bradypnoea 19.08 10.74 44 182895 5115 64310678
Procalcitonin increased 19.02 10.74 29 182910 2462 64313331
Nephrolithiasis 18.99 10.74 62 182877 43621 64272172
Patient isolation 18.96 10.74 7 182932 55 64315738
Cataplexy 18.95 10.74 17 182922 814 64314979
High arched palate 18.88 10.74 5 182934 10 64315783
Neck pain 18.85 10.74 100 182839 61433 64254360
Neglect of personal appearance 18.84 10.74 9 182930 142 64315651
Neutrophil Pelger-Huet anomaly present 18.81 10.74 12 182927 341 64315452
Lymphoma 18.76 10.74 8 182931 13933 64301860
Sleep disorder 18.74 10.74 255 182684 59454 64256339
Gastroenteritis viral 18.71 10.74 17 182922 19712 64296081
Tooth infection 18.68 10.74 9 182930 14592 64301201
Cerebral ventricle dilatation 18.66 10.74 18 182921 946 64314847
Metastases to lung 18.64 10.74 10 182929 15254 64300539
Multiple congenital abnormalities 18.62 10.74 8 182931 97 64315696
Swollen tongue 18.60 10.74 45 182894 34909 64280884
Dyspraxia 18.60 10.74 11 182928 272 64315521
Mixed delusion 18.56 10.74 5 182934 11 64315782
Low set ears 18.55 10.74 8 182931 98 64315695
School refusal 18.54 10.74 6 182933 30 64315763
Eye movement disorder 18.53 10.74 53 182886 7026 64308767
Intervertebral disc degeneration 18.52 10.74 7 182932 13113 64302680
Blood potassium decreased 18.50 10.74 56 182883 40343 64275450
COVID-19 pneumonia 18.48 10.74 12 182927 16492 64299301
Gene mutation 18.45 10.74 26 182913 2056 64313737
Red blood cell sedimentation rate increased 18.43 10.74 38 182901 31197 64284596
Illness 18.42 10.74 21 182918 21917 64293876
Tendon rupture 18.41 10.74 4 182935 10763 64305030
Blood gases abnormal 18.36 10.74 18 182921 965 64314828
Trismus 18.34 10.74 42 182897 4859 64310934
Transient ischaemic attack 18.32 10.74 64 182875 44118 64271675
Disorganised speech 18.30 10.74 23 182916 1627 64314166
Blood creatinine increased 18.22 10.74 273 182666 135509 64180284
Inhibitory drug interaction 18.14 10.74 35 182904 3592 64312201
Therapeutic product effective for unapproved indication 18.13 10.74 8 182931 104 64315689
Device difficult to use 18.11 10.74 3 182936 9795 64305998
Malignant catatonia 18.09 10.74 12 182927 365 64315428
Blood urea decreased 18.05 10.74 30 182909 2741 64313052
Atrial flutter 18.02 10.74 17 182922 19363 64296430
Coma hepatic 17.92 10.74 18 182921 994 64314799
Enteritis 17.80 10.74 6 182933 12071 64303722
Osmolar gap increased 17.78 10.74 6 182933 35 64315758
Immunodeficiency 17.68 10.74 12 182927 16112 64299681
Enterocolitis 17.67 10.74 6 182933 12012 64303781
White blood cell count decreased 17.66 10.74 579 182360 157258 64158535
Sedation complication 17.63 10.74 67 182872 10287 64305506
Epileptic aura 17.58 10.74 7 182932 69 64315724
Hepatic steatosis 17.51 10.74 149 182790 30858 64284935
Oxygen saturation decreased 17.47 10.74 207 182732 106969 64208824
Sciatica 17.45 10.74 19 182920 20245 64295548
Talipes 17.41 10.74 8 182931 115 64315678
Neutrophilia 17.40 10.74 50 182889 6644 64309149
Personal relationship issue 17.38 10.74 9 182930 170 64315623
Circadian rhythm sleep disorder 17.37 10.74 14 182925 578 64315215
Wrong schedule 17.29 10.74 11 182928 311 64315482
Blood pyruvic acid increased 17.24 10.74 4 182935 3 64315790
Camptodactyly congenital 17.24 10.74 4 182935 3 64315790
Lipids 17.21 10.74 5 182934 16 64315777
Emotional disorder of childhood 17.21 10.74 5 182934 16 64315777
Shock 17.19 10.74 175 182764 38065 64277728
Tooth disorder 17.17 10.74 23 182916 22379 64293414
Lacrimation increased 17.17 10.74 16 182923 18330 64297463
Laboratory test abnormal 17.16 10.74 26 182913 24037 64291756
Ear pain 17.13 10.74 28 182911 25108 64290685
Angular cheilitis 17.13 10.74 13 182926 491 64315302
Haematuria 17.04 10.74 101 182838 60370 64255423
Hypotonia neonatal 16.98 10.74 7 182932 76 64315717
Aptyalism 16.97 10.74 15 182924 704 64315089
Poor venous access 16.91 10.74 7 182932 12410 64303383
Mucosal erosion 16.91 10.74 24 182915 1910 64313883
Burning sensation 16.77 10.74 78 182861 49586 64266207
Myelodysplastic syndrome 16.75 10.74 33 182906 27546 64288247
Nephropathy toxic 16.72 10.74 15 182924 17499 64298294
Parkinsonian gait 16.71 10.74 16 182923 833 64314960
Hyperhomocysteinaemia 16.63 10.74 12 182927 419 64315374
Cardiac steatosis 16.61 10.74 6 182933 44 64315749
Hepatotoxicity 16.61 10.74 180 182759 39782 64276011
Tooth malformation 16.59 10.74 7 182932 81 64315712
Venoocclusive liver disease 16.57 10.74 4 182935 10011 64305782
Lacrimal gland enlargement 16.55 10.74 5 182934 19 64315774
Clinodactyly 16.55 10.74 5 182934 19 64315774
Dermatitis 16.55 10.74 16 182923 18013 64297780
Compensatory sweating 16.50 10.74 6 182933 45 64315748
Feeling cold 16.49 10.74 26 182913 23652 64292141
Shock haemorrhagic 16.49 10.74 14 182925 16777 64299016
Water intoxication 16.43 10.74 15 182924 735 64315058
Haematotoxicity 16.42 10.74 8 182931 12888 64302905
Procedural pain 16.40 10.74 12 182927 15496 64300297
Brain death 16.39 10.74 40 182899 4821 64310972
Blood pressure systolic abnormal 16.39 10.74 4 182935 9938 64305855
Influenza like illness 16.38 10.74 105 182834 61597 64254196
Hypercalcaemia 16.29 10.74 41 182898 31375 64284418
Congenital foot malformation 16.24 10.74 4 182935 5 64315788
Rotator cuff syndrome 16.21 10.74 7 182932 12100 64303693
Type 1 diabetes mellitus 16.20 10.74 44 182895 5661 64310132
Influenza B virus test positive 16.14 10.74 11 182928 350 64315443
Prothrombin time shortened 16.14 10.74 29 182910 2820 64312973
Torticollis 16.14 10.74 25 182914 2152 64313641
Posterior reversible encephalopathy syndrome 16.13 10.74 116 182823 22830 64292963
Dermatitis contact 16.11 10.74 3 182936 8997 64306796
Deep vein thrombosis 16.07 10.74 206 182733 104976 64210817
Disease recurrence 16.03 10.74 148 182791 31362 64284431
Conversion disorder 16.03 10.74 22 182917 1697 64314096
Gender dysphoria 15.95 10.74 6 182933 50 64315743
Mucosal ulceration 15.95 10.74 22 182917 1705 64314088
Mass 15.92 10.74 12 182927 15264 64300529
Acquired macroglossia 15.92 10.74 9 182930 204 64315589
Osteomyelitis 15.91 10.74 34 182905 27553 64288240
Diplopia 15.85 10.74 130 182809 26635 64289158
Opisthotonus 15.84 10.74 14 182925 657 64315136
Polyarthritis 15.84 10.74 4 182935 9711 64306082
Mastication disorder 15.82 10.74 26 182913 2353 64313440
Pneumonia fungal 15.80 10.74 3 182936 8874 64306919
Spinal fracture 15.72 10.74 12 182927 15162 64300631
Anaemia macrocytic 15.70 10.74 37 182902 4361 64311432
Heat stroke 15.69 10.74 20 182919 1435 64314358
Rebound psychosis 15.65 10.74 8 182931 147 64315646
Pyromania 15.62 10.74 5 182934 24 64315769
Glaucoma 15.61 10.74 14 182925 16334 64299459
Tooth abscess 15.55 10.74 10 182929 13816 64301977
Cardiogenic shock 15.54 10.74 44 182895 32383 64283410
Graft versus host disease 15.53 10.74 10 182929 13803 64301990
MELAS syndrome 15.51 10.74 8 182931 150 64315643
Duodenal ulcer 15.49 10.74 11 182928 14424 64301369
Pulmonary eosinophilia 15.48 10.74 13 182926 569 64315224
Polyserositis 15.43 10.74 12 182927 470 64315323
Pancreatitis haemorrhagic 15.42 10.74 13 182926 572 64315221
Hyperreflexia 15.41 10.74 50 182889 7098 64308695
Intention tremor 15.40 10.74 14 182925 682 64315111
Patent ductus arteriosus 15.40 10.74 7 182932 98 64315695
Idiosyncratic drug reaction 15.40 10.74 18 182921 1181 64314612
Alcohol abuse 15.39 10.74 39 182900 4813 64310980
Extensor plantar response 15.31 10.74 21 182918 1619 64314174
Sinus tachycardia 15.29 10.74 149 182790 32039 64283754
Nose deformity 15.27 10.74 8 182931 155 64315638
Bone disorder 15.24 10.74 15 182924 16744 64299049
Snoring 15.23 10.74 38 182901 4644 64311149
Gastroenteritis 15.23 10.74 39 182900 29672 64286121
Personality disorder 15.08 10.74 38 182901 4673 64311120
Diabetic hyperosmolar coma 15.06 10.74 14 182925 702 64315091
Rebound effect 15.05 10.74 39 182900 4878 64310915
Amino acid level increased 15.04 10.74 13 182926 592 64315201
Device dislocation 14.99 10.74 23 182916 21155 64294638
Psychomotor disadaptation syndrome 14.99 10.74 5 182934 28 64315765
Brain injury 14.97 10.74 62 182877 9903 64305890
Astigmatism 14.97 10.74 17 182922 1081 64314712
Embolism 14.97 10.74 8 182931 12227 64303566
Rotavirus infection 14.89 10.74 13 182926 600 64315193
Cholangitis 14.86 10.74 6 182933 10796 64304997
Electrocardiogram J wave abnormal 14.78 10.74 4 182935 9 64315784
Congenital renal disorder 14.78 10.74 4 182935 9 64315784
Clonic convulsion 14.71 10.74 17 182922 1102 64314691
Back disorder 14.66 10.74 5 182934 9985 64305808
Product administration error 14.66 10.74 131 182808 27512 64288281
Sperm concentration decreased 14.65 10.74 6 182933 64 64315729
Dissociative disorder 14.62 10.74 11 182928 410 64315383
Urine sodium increased 14.61 10.74 8 182931 170 64315623
Dacryoadenitis acquired 14.60 10.74 3 182936 0 64315793
Diabetic encephalopathy 14.60 10.74 3 182936 0 64315793
Nasopharyngeal reflux 14.60 10.74 3 182936 0 64315793
3-hydroxyacetyl-coenzyme A dehydrogenase deficiency 14.60 10.74 3 182936 0 64315793
Lisfranc fracture 14.60 10.74 3 182936 0 64315793
Congenital scoliosis 14.60 10.74 3 182936 0 64315793
Social (pragmatic) communication disorder 14.60 10.74 3 182936 0 64315793
Congenital eyelid malformation 14.60 10.74 3 182936 0 64315793
Near drowning 14.56 10.74 5 182934 31 64315762
Slow response to stimuli 14.55 10.74 20 182919 1545 64314248
Poor personal hygiene 14.53 10.74 12 182927 513 64315280
Erythema multiforme 14.48 10.74 85 182854 15616 64300177
Feminisation acquired 14.42 10.74 5 182934 32 64315761
Glioblastoma multiforme 14.40 10.74 17 182922 1127 64314666
Posturing 14.36 10.74 16 182923 996 64314797
Hyporeflexia 14.28 10.74 30 182909 3274 64312519
Abulia 14.24 10.74 15 182924 876 64314917
Cerebral arteriosclerosis 14.24 10.74 14 182925 753 64315040
Diverticulum 14.24 10.74 10 182929 13188 64302605
Pathogen resistance 14.21 10.74 9 182930 12534 64303259
Pneumonia bacterial 14.20 10.74 13 182926 15022 64300771
Ankylosing spondylitis 14.20 10.74 3 182936 8231 64307562
Delusional perception 14.20 10.74 10 182929 336 64315457
Rickets 14.17 10.74 6 182933 70 64315723
Fanconi syndrome acquired 14.17 10.74 25 182914 2396 64313397
Fistula 14.13 10.74 5 182934 9756 64306037
Retinitis pigmentosa 14.13 10.74 7 182932 120 64315673
Body temperature decreased 14.10 10.74 33 182906 25895 64289898
Hypokalaemia 14.07 10.74 252 182687 121651 64194142
Eosinophil count increased 14.07 10.74 78 182861 14034 64301759
Myelosuppression 14.06 10.74 29 182910 23801 64291992
Insomnia 14.04 10.74 691 182248 197145 64118648
Bronchospasm 14.00 10.74 25 182914 21657 64294136
Opsoclonus myoclonus 13.97 10.74 8 182931 186 64315607
Locomotive syndrome 13.96 10.74 4 182935 12 64315781
Amino acid metabolism disorder 13.96 10.74 4 182935 12 64315781
Ketosis-prone diabetes mellitus 13.96 10.74 4 182935 12 64315781
Abdominal distension 13.93 10.74 190 182749 95804 64219989
Gingival atrophy 13.88 10.74 6 182933 74 64315719
Renal tubular necrosis 13.82 10.74 26 182913 22084 64293709
Anticoagulation drug level decreased 13.77 10.74 7 182932 127 64315666
Drug eruption 13.76 10.74 160 182779 35976 64279817
Unmasking of previously unidentified disease 13.76 10.74 20 182919 1627 64314166
Derealisation 13.74 10.74 19 182920 1476 64314317
False positive investigation result 13.73 10.74 14 182925 787 64315006
Spinal compression fracture 13.69 10.74 13 182926 14762 64301031
Musculoskeletal chest pain 13.66 10.74 25 182914 21454 64294339
Small intestinal obstruction 13.64 10.74 29 182910 23544 64292249
Staphylococcal infection 13.57 10.74 86 182853 50592 64265201
Altered visual depth perception 13.50 10.74 10 182929 364 64315429
Ehlers-Danlos syndrome 13.48 10.74 7 182932 133 64315660
Visuospatial deficit 13.47 10.74 5 182934 40 64315753
Polydipsia psychogenic 13.45 10.74 8 182931 200 64315593
Gastrointestinal sounds abnormal 13.40 10.74 37 182902 4806 64310987
Hyperdynamic left ventricle 13.33 10.74 9 182930 282 64315511
SJS-TEN overlap 13.33 10.74 11 182928 470 64315323
Escherichia infection 13.31 10.74 14 182925 15154 64300639
Toothache 13.31 10.74 18 182921 17441 64298352
Terminal insomnia 13.27 10.74 15 182924 949 64314844
Wrong technique in product usage process 13.25 10.74 119 182820 64855 64250938
Lower gastrointestinal haemorrhage 13.23 10.74 12 182927 13927 64301866
Hypoacusis 13.22 10.74 34 182905 25833 64289960
Factor XIII deficiency 13.20 10.74 6 182933 84 64315709
Type 2 diabetes mellitus 13.12 10.74 151 182788 33869 64281924
Urine calcium/creatinine ratio increased 13.12 10.74 7 182932 141 64315652
Hypoventilation 12.94 10.74 42 182897 5964 64309829
Accidental death 12.94 10.74 31 182908 3694 64312099
Diabetic coma 12.92 10.74 16 182923 1115 64314678
Precocious puberty 12.92 10.74 9 182930 297 64315496
Tubo-ovarian abscess 12.92 10.74 9 182930 297 64315496
Synovial cyst 12.90 10.74 3 182936 7704 64308089
Gynaecomastia 12.90 10.74 42 182897 5974 64309819
Lip erosion 12.89 10.74 17 182922 1262 64314531
Lipids abnormal 12.84 10.74 11 182928 495 64315298
Lip haemorrhage 12.83 10.74 16 182923 1123 64314670
Skin irritation 12.82 10.74 5 182934 9189 64306604
Squamous cell carcinoma of skin 12.81 10.74 9 182930 11867 64303926
Ejaculation disorder 12.80 10.74 11 182928 497 64315296
Acute psychosis 12.79 10.74 31 182908 3721 64312072
Renal injury 12.70 10.74 15 182924 15414 64300379
Hepatocellular carcinoma 12.70 10.74 4 182935 8399 64307394
Epileptic encephalopathy 12.68 10.74 10 182929 400 64315393
Drug screen false positive 12.68 10.74 15 182924 997 64314796
Serositis 12.57 10.74 13 182926 743 64315050
Coloboma 12.53 10.74 3 182936 3 64315790
Delusional disorder, mixed type 12.53 10.74 3 182936 3 64315790
Liver injury 12.52 10.74 135 182804 29797 64285996
Coma blister 12.52 10.74 8 182931 228 64315565
Cytotoxic oedema 12.51 10.74 9 182930 313 64315480
Organising pneumonia 12.50 10.74 5 182934 9050 64306743
Malignant melanoma 12.50 10.74 11 182928 12953 64302840
Cardiovascular disorder 12.49 10.74 16 182923 15865 64299928
Withdrawal catatonia 12.48 10.74 7 182932 156 64315637
Cerebral palsy 12.48 10.74 7 182932 156 64315637
Intraocular pressure increased 12.46 10.74 4 182935 8298 64307495
Thermal burn 12.45 10.74 41 182898 5865 64309928
Herbal interaction 12.43 10.74 10 182929 412 64315381
Strabismus 12.42 10.74 22 182917 2115 64313678
Wrong product administered 12.37 10.74 49 182890 7671 64308122
Hyperpyrexia 12.32 10.74 37 182902 5040 64310753
Cardiac failure acute 12.31 10.74 17 182922 16327 64299466
Blunted affect 12.30 10.74 10 182929 418 64315375
Hepatomegaly 12.25 10.74 86 182853 16796 64298997
Pupillary reflex impaired 12.25 10.74 27 182912 3046 64312747
Skin fissures 12.23 10.74 7 182932 10299 64305494
Diverticulum intestinal 12.20 10.74 3 182936 7417 64308376
Infertility male 12.16 10.74 6 182933 102 64315691
Post procedural infection 12.15 10.74 6 182933 9591 64306202
Compulsive sexual behaviour 12.10 10.74 8 182931 242 64315551
Retinal function test abnormal 12.07 10.74 3 182936 4 64315789
Intermittent explosive disorder 12.07 10.74 3 182936 4 64315789
Coronary artery occlusion 11.99 10.74 13 182926 13878 64301915
Large intestine polyp 11.97 10.74 8 182931 10829 64304964
Substance-induced psychotic disorder 11.89 10.74 25 182914 2730 64313063
Laryngeal stenosis 11.87 10.74 13 182926 794 64314999
Hepatitis fulminant 11.86 10.74 42 182897 6232 64309561
Upper-airway cough syndrome 11.85 10.74 5 182934 8765 64307028
Cyst 11.84 10.74 10 182929 12017 64303776
Sleep-related eating disorder 11.84 10.74 12 182927 670 64315123
Respiratory syncytial virus infection 11.83 10.74 3 182936 7265 64308528
Vasoplegia syndrome 11.81 10.74 25 182914 2742 64313051
Immunosuppressant drug level increased 11.81 10.74 3 182936 7256 64308537
Groin pain 11.81 10.74 9 182930 11384 64304409
Blood insulin increased 11.81 10.74 9 182930 342 64315451
Nipple disorder 11.77 10.74 7 182932 175 64315618
Blood citric acid increased 11.76 10.74 5 182934 59 64315734
Autoimmune hepatitis 11.75 10.74 7 182932 10077 64305716
Attention-seeking behaviour 11.75 10.74 6 182933 110 64315683
Spinal disorder 11.75 10.74 5 182934 8717 64307076
Vascular encephalopathy 11.68 10.74 11 182928 561 64315232
Waxy flexibility 11.67 10.74 8 182931 257 64315536
Endocarditis 11.67 10.74 6 182933 9372 64306421
Wound infection 11.66 10.74 15 182924 14849 64300944
Drug-induced liver injury 11.66 10.74 195 182744 47448 64268345
Non-cardiac chest pain 11.65 10.74 5 182934 8675 64307118
Acute generalised exanthematous pustulosis 11.64 10.74 74 182865 13984 64301809
Orthostatic tremor 11.62 10.74 4 182935 25 64315768
Breast cancer metastatic 11.59 10.74 3 182936 7166 64308627
Eclampsia 11.56 10.74 7 182932 181 64315612
Haematuria traumatic 11.49 10.74 7 182932 183 64315610
Osteoporosis 11.48 10.74 71 182868 42009 64273784
Plasmodium falciparum infection 11.47 10.74 5 182934 63 64315730
Post-acute COVID-19 syndrome 11.47 10.74 5 182934 63 64315730
Ischaemic stroke 11.42 10.74 43 182896 28992 64286801
Antidepressant drug level increased 11.39 10.74 9 182930 361 64315432
Arthritis bacterial 11.37 10.74 4 182935 7835 64307958
Illiteracy 11.36 10.74 4 182935 27 64315766
Blood bicarbonate increased 11.36 10.74 15 182924 1115 64314678
Hydronephrosis 11.35 10.74 14 182925 14111 64301682
Pneumonia viral 11.33 10.74 4 182935 7818 64307975
Parkinson's disease 11.33 10.74 18 182921 1583 64314210
Rasmussen encephalitis 11.33 10.74 3 182936 6 64315787
Ornithine transcarbamoylase deficiency 11.33 10.74 3 182936 6 64315787
Congenital renal cyst 11.33 10.74 3 182936 6 64315787
Drug half-life reduced 11.33 10.74 3 182936 6 64315787
Neutrophil count decreased 11.32 10.74 293 182646 76903 64238890
Urosepsis 11.32 10.74 29 182910 22065 64293728
Genital erosion 11.31 10.74 9 182930 365 64315428
Pulmonary thrombosis 11.30 10.74 8 182931 10510 64305283
Monocyte count decreased 11.27 10.74 25 182914 2832 64312961
Seasonal allergy 11.24 10.74 10 182929 11716 64304077
Mitochondrial enzyme deficiency 11.23 10.74 4 182935 28 64315765
Aphthous ulcer 11.22 10.74 12 182927 12894 64302899
Colitis ulcerative 11.22 10.74 31 182908 22997 64292796
Heparin-induced thrombocytopenia 11.20 10.74 5 182934 8474 64307319
Restless legs syndrome 11.16 10.74 85 182854 17031 64298762
Libido increased 11.15 10.74 19 182920 1771 64314022
Pulmonary valve incompetence 11.12 10.74 18 182921 1608 64314185
CSF white blood cell count positive 11.11 10.74 4 182935 29 64315764
Echopraxia 11.11 10.74 4 182935 29 64315764
Hyporesponsive to stimuli 11.10 10.74 19 182920 1778 64314015
Megacolon 11.08 10.74 26 182913 3056 64312737
Poriomania 11.06 10.74 7 182932 196 64315597
Decreased activity 11.05 10.74 45 182894 7135 64308658
Acute pulmonary oedema 11.04 10.74 12 182927 12797 64302996
Frequent bowel movements 11.03 10.74 22 182917 18283 64297510
Personality change 11.03 10.74 51 182888 8542 64307251
Muscle tone disorder 11.02 10.74 6 182933 126 64315667
Therapeutic product effect variable 10.98 10.74 18 182921 1626 64314167
Internal haemorrhage 10.97 10.74 4 182935 7663 64308130
Dermatitis bullous 10.95 10.74 65 182874 11989 64303804
Dysuria 10.94 10.74 72 182867 41985 64273808
Hypogonadism male 10.94 10.74 6 182933 128 64315665
Multiple sclerosis relapse 10.92 10.74 70 182869 41065 64274728
Alanine aminotransferase abnormal 10.92 10.74 3 182936 6885 64308908
Coma acidotic 10.89 10.74 6 182933 129 64315664
Sinus bradycardia 10.89 10.74 106 182833 22787 64293006
Renal cancer 10.89 10.74 3 182936 6872 64308921
Blood pressure diastolic decreased 10.88 10.74 30 182909 22271 64293522
Intestinal pseudo-obstruction 10.88 10.74 20 182919 1980 64313813
Pharyngeal oedema 10.87 10.74 17 182922 15514 64300279
Hyperthyroidism 10.83 10.74 22 182917 18157 64297636
Excessive masturbation 10.81 10.74 5 182934 73 64315720
Myoglobin blood increased 10.79 10.74 24 182915 2723 64313070
Gastrointestinal pain 10.76 10.74 4 182935 7570 64308223
Cyclothymic disorder 10.75 10.74 7 182932 206 64315587

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal anticonvulsant syndrome 147.75 26.17 41 836 0 83801
Congenital nose malformation 57.43 26.17 16 861 0 83801
Low set ears 41.33 26.17 15 862 20 83781
Dysmorphism 35.74 26.17 32 845 402 83399
Cardiomegaly 28.68 26.17 8 869 0 83801
Developmental delay 27.36 26.17 14 863 61 83740

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
CHEBI has role CHEBI:35471 psychotropic drugs
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:63726 neuroprotective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Aldose reductase Enzyme IC50 4.25 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Aldose reductase-related protein 1 Enzyme IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
D00304 KEGG_DRUG
76584-70-8 SECONDARY_CAS_RN
1069-66-5 SECONDARY_CAS_RN
4018723 VANDF
4018724 VANDF
4018728 VANDF
4022507 VANDF
C0042291 UMLSCUI
CHEBI:39867 CHEBI
2PP PDB_CHEM_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
CHEMBL2105613 ChEMBL_ID
CHEMBL433 ChEMBL_ID
D014635 MESH_DESCRIPTOR_UI
3121 PUBCHEM_CID
3300 INN_ID
7009 IUPHAR_LIGAND_ID
33433-82-8 SECONDARY_CAS_RN
614OI1Z5WI UNII
11118 RXNORM
147344 MMSL
17039 MMSL
203066 MMSL
255547 MMSL
3118 MMSL
4624 MMSL
5661 MMSL
5662 MMSL
942 MMSL
d00083 MMSL
d03833 MMSL
001622 NDDF
001623 NDDF
001624 NDDF
006036 NDDF
007107 NDDF
13965000 SNOMEDCT_US
387080000 SNOMEDCT_US
387481005 SNOMEDCT_US
5641004 SNOMEDCT_US
CHEMBL2315212 ChEMBL_ID
5132 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteSprinkles HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7325 TABLET, DELAYED RELEASE 125 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7327 TABLET, DELAYED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7401 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
DepakoteER HUMAN PRESCRIPTION DRUG LABEL 1 0074-7402 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 31 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 31 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 27 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 29 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 29 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 29 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0527-5250 SOLUTION 250 mg ORAL ANDA 30 sections