prednisolone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 2247 | 52-21-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.22 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 22, 1955 | FDA | SCHERING |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Treatment failure | 265.00 | 14.36 | 206 | 7369 | 198837 | 63282610 |
| Corneal epithelium defect | 193.80 | 14.36 | 34 | 7541 | 318 | 63481129 |
| Intraocular pressure increased | 188.34 | 14.36 | 56 | 7519 | 6022 | 63475425 |
| Eye irritation | 176.15 | 14.36 | 74 | 7501 | 21897 | 63459550 |
| Eye pain | 175.38 | 14.36 | 84 | 7491 | 33770 | 63447677 |
| Corneal oedema | 166.06 | 14.36 | 38 | 7537 | 1455 | 63479992 |
| Visual acuity reduced | 160.01 | 14.36 | 69 | 7506 | 21757 | 63459690 |
| Endophthalmitis | 146.53 | 14.36 | 41 | 7534 | 3551 | 63477896 |
| Corneal disorder | 143.30 | 14.36 | 35 | 7540 | 1779 | 63479668 |
| Vision blurred | 141.48 | 14.36 | 104 | 7471 | 91820 | 63389627 |
| Corneal opacity | 127.55 | 14.36 | 27 | 7548 | 716 | 63480731 |
| Toxic anterior segment syndrome | 109.09 | 14.36 | 28 | 7547 | 1743 | 63479704 |
| Punctate keratitis | 109.08 | 14.36 | 23 | 7552 | 598 | 63480849 |
| Ocular hyperaemia | 102.37 | 14.36 | 53 | 7522 | 25091 | 63456356 |
| Anterior chamber cell | 89.00 | 14.36 | 19 | 7556 | 525 | 63480922 |
| Uveitis | 86.46 | 14.36 | 38 | 7537 | 12515 | 63468932 |
| Product delivery mechanism issue | 84.18 | 14.36 | 17 | 7558 | 355 | 63481092 |
| Cataract | 79.77 | 14.36 | 61 | 7514 | 56992 | 63424455 |
| Eye inflammation | 77.32 | 14.36 | 28 | 7547 | 5571 | 63475876 |
| Hypopyon | 67.47 | 14.36 | 16 | 7559 | 716 | 63480731 |
| Corneal transplant | 63.99 | 14.36 | 13 | 7562 | 280 | 63481167 |
| Vitritis | 62.64 | 14.36 | 16 | 7559 | 976 | 63480471 |
| Foreign body sensation in eyes | 62.36 | 14.36 | 19 | 7556 | 2215 | 63479232 |
| Corneal infiltrates | 60.26 | 14.36 | 11 | 7564 | 131 | 63481316 |
| Glaucoma | 57.86 | 14.36 | 33 | 7542 | 18872 | 63462575 |
| Product container issue | 57.61 | 14.36 | 17 | 7558 | 1776 | 63479671 |
| Keratitis bacterial | 57.44 | 14.36 | 9 | 7566 | 38 | 63481409 |
| Photophobia | 54.55 | 14.36 | 31 | 7544 | 17604 | 63463843 |
| Keratitis | 54.40 | 14.36 | 19 | 7556 | 3403 | 63478044 |
| Corneal graft rejection | 53.70 | 14.36 | 8 | 7567 | 22 | 63481425 |
| Corneal deposits | 52.12 | 14.36 | 11 | 7564 | 287 | 63481160 |
| Visual impairment | 52 | 14.36 | 57 | 7518 | 84389 | 63397058 |
| Iridocyclitis | 47.89 | 14.36 | 16 | 7559 | 2506 | 63478941 |
| Vitreous haemorrhage | 47.00 | 14.36 | 15 | 7560 | 2035 | 63479412 |
| Iritis | 44.29 | 14.36 | 16 | 7559 | 3159 | 63478288 |
| Corneal scar | 43.10 | 14.36 | 8 | 7567 | 105 | 63481342 |
| Conjunctival ulcer | 42.92 | 14.36 | 7 | 7568 | 40 | 63481407 |
| Cystoid macular oedema | 42.28 | 14.36 | 13 | 7562 | 1562 | 63479885 |
| Tractional retinal detachment | 42.08 | 14.36 | 7 | 7568 | 46 | 63481401 |
| Cataract subcapsular | 39.51 | 14.36 | 10 | 7565 | 588 | 63480859 |
| Ulcerative keratitis | 39.09 | 14.36 | 14 | 7561 | 2696 | 63478751 |
| Conjunctival hyperaemia | 37.01 | 14.36 | 13 | 7562 | 2366 | 63479081 |
| Rhegmatogenous retinal detachment | 36.60 | 14.36 | 7 | 7568 | 109 | 63481338 |
| Hyphaema | 35.34 | 14.36 | 8 | 7567 | 291 | 63481156 |
| Vitreous floaters | 34.53 | 14.36 | 16 | 7559 | 5950 | 63475497 |
| Retinal detachment | 34.52 | 14.36 | 16 | 7559 | 5953 | 63475494 |
| Infectious crystalline keratopathy | 33.50 | 14.36 | 5 | 7570 | 14 | 63481433 |
| Complications of transplant surgery | 33.38 | 14.36 | 7 | 7568 | 177 | 63481270 |
| Corneal perforation | 30.53 | 14.36 | 8 | 7567 | 540 | 63480907 |
| Product residue present | 30.51 | 14.36 | 13 | 7562 | 3966 | 63477481 |
| Eye infection toxoplasmal | 30.09 | 14.36 | 7 | 7568 | 288 | 63481159 |
| Fibrous histiocytoma | 29.98 | 14.36 | 8 | 7567 | 579 | 63480868 |
| Blindness | 29.85 | 14.36 | 23 | 7552 | 21676 | 63459771 |
| Ocular discomfort | 29.74 | 14.36 | 13 | 7562 | 4220 | 63477227 |
| Product quality issue | 28.91 | 14.36 | 28 | 7547 | 35837 | 63445610 |
| Foreign body in eye | 28.87 | 14.36 | 6 | 7569 | 145 | 63481302 |
| Hypotony of eye | 28.68 | 14.36 | 6 | 7569 | 150 | 63481297 |
| Liquid product physical issue | 28.55 | 14.36 | 9 | 7566 | 1173 | 63480274 |
| Immobile | 28.48 | 14.36 | 14 | 7561 | 5929 | 63475518 |
| Eye discharge | 28.22 | 14.36 | 14 | 7561 | 6049 | 63475398 |
| Eye disorder | 26.83 | 14.36 | 22 | 7553 | 22663 | 63458784 |
| Scleral thinning | 25.51 | 14.36 | 4 | 7571 | 17 | 63481430 |
| Corneal thinning | 24.59 | 14.36 | 5 | 7570 | 108 | 63481339 |
| Infective keratitis | 22.64 | 14.36 | 4 | 7571 | 39 | 63481408 |
| Instillation site pain | 22.32 | 14.36 | 7 | 7568 | 897 | 63480550 |
| Macular oedema | 21.20 | 14.36 | 10 | 7565 | 3867 | 63477580 |
| Astigmatism | 21.18 | 14.36 | 7 | 7568 | 1060 | 63480387 |
| Corneal abrasion | 20.82 | 14.36 | 7 | 7568 | 1117 | 63480330 |
| Metamorphopsia | 20.59 | 14.36 | 7 | 7568 | 1156 | 63480291 |
| Lenticular opacities | 20.52 | 14.36 | 5 | 7570 | 251 | 63481196 |
| Lacrimation increased | 20.29 | 14.36 | 18 | 7557 | 20613 | 63460834 |
| Off label use | 19.95 | 14.36 | 143 | 7432 | 674319 | 62807128 |
| Instillation site foreign body sensation | 19.70 | 14.36 | 3 | 7572 | 10 | 63481437 |
| Angle closure glaucoma | 19.54 | 14.36 | 8 | 7567 | 2211 | 63479236 |
| Blindness unilateral | 19.37 | 14.36 | 11 | 7564 | 6230 | 63475217 |
| Vitreous opacities | 19.31 | 14.36 | 5 | 7570 | 322 | 63481125 |
| Persistent corneal epithelial defect | 19.28 | 14.36 | 3 | 7572 | 12 | 63481435 |
| Corneal neovascularisation | 18.65 | 14.36 | 4 | 7571 | 113 | 63481334 |
| Product complaint | 18.55 | 14.36 | 14 | 7561 | 12795 | 63468652 |
| Bedridden | 18.08 | 14.36 | 13 | 7562 | 11038 | 63470409 |
| Corneal endotheliitis | 17.99 | 14.36 | 3 | 7572 | 20 | 63481427 |
| Lower limb fracture | 17.83 | 14.36 | 18 | 7557 | 24203 | 63457244 |
| Corneal thickening | 17.74 | 14.36 | 3 | 7572 | 22 | 63481425 |
| Accidental exposure to product | 17.72 | 14.36 | 19 | 7556 | 27386 | 63454061 |
| Cytomegalovirus chorioretinitis | 17.63 | 14.36 | 7 | 7568 | 1786 | 63479661 |
| Keratitis fungal | 17.23 | 14.36 | 4 | 7571 | 163 | 63481284 |
| Corynebacterium infection | 16.65 | 14.36 | 5 | 7570 | 554 | 63480893 |
| Foot fracture | 16.21 | 14.36 | 17 | 7558 | 23897 | 63457550 |
| Eye swelling | 16.21 | 14.36 | 17 | 7558 | 23901 | 63457546 |
| Keratopathy | 16.18 | 14.36 | 5 | 7570 | 611 | 63480836 |
| Conjunctival haemorrhage | 15.86 | 14.36 | 8 | 7567 | 3579 | 63477868 |
| Product substitution issue | 15.82 | 14.36 | 14 | 7561 | 15982 | 63465465 |
| Eye operation | 15.74 | 14.36 | 7 | 7568 | 2365 | 63479082 |
| Product physical consistency issue | 15.55 | 14.36 | 5 | 7570 | 694 | 63480753 |
| Conjunctival oedema | 15.53 | 14.36 | 5 | 7570 | 697 | 63480750 |
| Retinitis viral | 15.33 | 14.36 | 3 | 7572 | 53 | 63481394 |
| Vitreous haze | 15.33 | 14.36 | 3 | 7572 | 53 | 63481394 |
| Open angle glaucoma | 15.26 | 14.36 | 4 | 7571 | 270 | 63481177 |
| Corneal erosion | 14.86 | 14.36 | 4 | 7571 | 299 | 63481148 |
| Anterior chamber inflammation | 14.56 | 14.36 | 4 | 7571 | 323 | 63481124 |
| Abnormal sensation in eye | 14.36 | 14.36 | 6 | 7569 | 1743 | 63479704 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Endophthalmitis | 264.47 | 17.09 | 69 | 5485 | 3439 | 34947938 |
| Treatment failure | 256.82 | 17.09 | 132 | 5422 | 46565 | 34904812 |
| Intraocular pressure increased | 222.08 | 17.09 | 66 | 5488 | 5317 | 34946060 |
| Eye pain | 205.18 | 17.09 | 78 | 5476 | 13384 | 34937993 |
| Visual acuity reduced | 144.77 | 17.09 | 64 | 5490 | 16085 | 34935292 |
| Corneal oedema | 123.46 | 17.09 | 31 | 5523 | 1320 | 34950057 |
| Cataract | 109.96 | 17.09 | 62 | 5492 | 26124 | 34925253 |
| Corneal epithelium defect | 102.04 | 17.09 | 21 | 5533 | 358 | 34951019 |
| Ulcerative keratitis | 97.21 | 17.09 | 27 | 5527 | 1702 | 34949675 |
| Corneal opacity | 82.18 | 17.09 | 19 | 5535 | 567 | 34950810 |
| Glaucoma | 73.73 | 17.09 | 31 | 5523 | 6881 | 34944496 |
| Choroiditis | 73.04 | 17.09 | 20 | 5534 | 1195 | 34950182 |
| Toxic anterior segment syndrome | 69.15 | 17.09 | 19 | 5535 | 1150 | 34950227 |
| Ocular hyperaemia | 67.46 | 17.09 | 34 | 5520 | 11418 | 34939959 |
| Uveitis | 64.70 | 17.09 | 29 | 5525 | 7506 | 34943871 |
| Corneal scar | 55.74 | 17.09 | 11 | 5543 | 150 | 34951227 |
| Vision blurred | 55.60 | 17.09 | 51 | 5503 | 45912 | 34905465 |
| Eye irritation | 55.20 | 17.09 | 26 | 5528 | 7535 | 34943842 |
| Foreign body sensation in eyes | 55.20 | 17.09 | 14 | 5540 | 620 | 34950757 |
| Cystoid macular oedema | 53.53 | 17.09 | 14 | 5540 | 701 | 34950676 |
| Anterior chamber cell | 46.47 | 17.09 | 11 | 5543 | 364 | 34951013 |
| Flat anterior chamber of eye | 45.49 | 17.09 | 8 | 5546 | 55 | 34951322 |
| Corneal disorder | 45.31 | 17.09 | 13 | 5541 | 921 | 34950456 |
| Keratitis | 43.74 | 17.09 | 14 | 5540 | 1437 | 34949940 |
| Astigmatism | 43.25 | 17.09 | 13 | 5541 | 1084 | 34950293 |
| Corneal perforation | 41.68 | 17.09 | 9 | 5545 | 195 | 34951182 |
| Vitritis | 41.43 | 17.09 | 12 | 5542 | 879 | 34950498 |
| NPM1 gene mutation | 39.95 | 17.09 | 8 | 5546 | 118 | 34951259 |
| Corneal thinning | 38.72 | 17.09 | 8 | 5546 | 139 | 34951238 |
| Corneal infiltrates | 37.99 | 17.09 | 8 | 5546 | 153 | 34951224 |
| Photophobia | 36.16 | 17.09 | 19 | 5535 | 6945 | 34944432 |
| Bronchiolitis obliterans syndrome | 36.03 | 17.09 | 8 | 5546 | 198 | 34951179 |
| Chimerism | 34.71 | 17.09 | 8 | 5546 | 235 | 34951142 |
| Iris adhesions | 34.36 | 17.09 | 8 | 5546 | 246 | 34951131 |
| Eye infection | 34.30 | 17.09 | 15 | 5539 | 3658 | 34947719 |
| Eye inflammation | 30.70 | 17.09 | 12 | 5542 | 2206 | 34949171 |
| CSF pressure increased | 30.70 | 17.09 | 5 | 5549 | 20 | 34951357 |
| Corneal deposits | 30.01 | 17.09 | 7 | 5547 | 217 | 34951160 |
| Iris atrophy | 29.93 | 17.09 | 6 | 5548 | 89 | 34951288 |
| Corneal graft rejection | 28.74 | 17.09 | 5 | 5549 | 32 | 34951345 |
| Keratitis fungal | 27.20 | 17.09 | 6 | 5548 | 144 | 34951233 |
| Idiopathic intracranial hypertension | 26.31 | 17.09 | 8 | 5546 | 693 | 34950684 |
| Hypopyon | 26.05 | 17.09 | 7 | 5547 | 389 | 34950988 |
| Retinal detachment | 25.99 | 17.09 | 14 | 5540 | 5377 | 34946000 |
| Visual impairment | 25.63 | 17.09 | 30 | 5524 | 35772 | 34915605 |
| Necrotising scleritis | 24.77 | 17.09 | 5 | 5549 | 77 | 34951300 |
| Liquid product physical issue | 24.41 | 17.09 | 7 | 5547 | 495 | 34950882 |
| Ocular discomfort | 24.19 | 17.09 | 10 | 5544 | 2124 | 34949253 |
| Eye disorder | 23.26 | 17.09 | 16 | 5538 | 9512 | 34941865 |
| Conjunctival hyperaemia | 23.05 | 17.09 | 10 | 5544 | 2392 | 34948985 |
| Pupillary disorder | 22.59 | 17.09 | 6 | 5548 | 319 | 34951058 |
| Ophthalmic herpes simplex | 22.50 | 17.09 | 6 | 5548 | 324 | 34951053 |
| Vitreous opacities | 21.86 | 17.09 | 6 | 5548 | 361 | 34951016 |
| Persistent corneal epithelial defect | 21.79 | 17.09 | 4 | 5550 | 36 | 34951341 |
| Product delivery mechanism issue | 21.19 | 17.09 | 5 | 5549 | 163 | 34951214 |
| Iris hypopigmentation | 20.98 | 17.09 | 4 | 5550 | 45 | 34951332 |
| Ocular hypertension | 20.82 | 17.09 | 7 | 5547 | 837 | 34950540 |
| Blindness | 20.81 | 17.09 | 18 | 5536 | 14968 | 34936409 |
| Blood immunoglobulin G decreased | 20.49 | 17.09 | 8 | 5546 | 1465 | 34949912 |
| Open globe injury | 20.30 | 17.09 | 3 | 5551 | 5 | 34951372 |
| Vitreous floaters | 19.23 | 17.09 | 10 | 5544 | 3575 | 34947802 |
| Immunosuppression | 18.81 | 17.09 | 12 | 5542 | 6292 | 34945085 |
| Dry eye | 18.61 | 17.09 | 14 | 5540 | 9561 | 34941816 |
| Epstein-Barr virus associated lymphoproliferative disorder | 18.27 | 17.09 | 8 | 5546 | 1956 | 34949421 |
| Eye discharge | 18.11 | 17.09 | 8 | 5546 | 1998 | 34949379 |
| Transplant rejection | 17.69 | 17.09 | 14 | 5540 | 10297 | 34941080 |
| Acute myeloid leukaemia recurrent | 17.51 | 17.09 | 8 | 5546 | 2162 | 34949215 |
| Steroid diabetes | 17.42 | 17.09 | 8 | 5546 | 2187 | 34949190 |
| Articular disc disorder | 17.41 | 17.09 | 3 | 5551 | 18 | 34951359 |
| Blepharitis | 17.16 | 17.09 | 7 | 5547 | 1438 | 34949939 |
| Punctate keratitis | 17.11 | 17.09 | 5 | 5549 | 378 | 34950999 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Endophthalmitis | 388.45 | 13.91 | 103 | 10862 | 6325 | 79727098 |
| Intraocular pressure increased | 365.12 | 13.91 | 106 | 10859 | 9099 | 79724324 |
| Corneal epithelium defect | 280.30 | 13.91 | 53 | 10912 | 666 | 79732757 |
| Visual acuity reduced | 267.68 | 13.91 | 113 | 10852 | 29356 | 79704067 |
| Eye pain | 263.19 | 13.91 | 120 | 10845 | 37458 | 79695965 |
| Corneal oedema | 262.88 | 13.91 | 63 | 10902 | 2557 | 79730866 |
| Corneal opacity | 180.70 | 13.91 | 39 | 10926 | 981 | 79732442 |
| Corneal disorder | 163.89 | 13.91 | 42 | 10923 | 2249 | 79731174 |
| Toxic anterior segment syndrome | 151.38 | 13.91 | 41 | 10924 | 2723 | 79730700 |
| Uveitis | 134.53 | 13.91 | 59 | 10906 | 16771 | 79716652 |
| Anterior chamber cell | 127.88 | 13.91 | 29 | 10936 | 920 | 79732503 |
| Vision blurred | 127.41 | 13.91 | 110 | 10855 | 105788 | 79627635 |
| Ulcerative keratitis | 122.29 | 13.91 | 37 | 10928 | 3652 | 79729771 |
| Cataract | 119.11 | 13.91 | 85 | 10880 | 62035 | 79671388 |
| Punctate keratitis | 116.11 | 13.91 | 27 | 10938 | 959 | 79732464 |
| Glaucoma | 104.31 | 13.91 | 52 | 10913 | 19709 | 79713714 |
| Vitritis | 100.06 | 13.91 | 27 | 10938 | 1767 | 79731656 |
| Eye irritation | 99.17 | 13.91 | 51 | 10914 | 20630 | 79712793 |
| Ocular hyperaemia | 97.52 | 13.91 | 56 | 10909 | 28150 | 79705273 |
| Hypopyon | 86.91 | 13.91 | 22 | 10943 | 1120 | 79732303 |
| Corneal scar | 84.97 | 13.91 | 17 | 10948 | 291 | 79733132 |
| Foreign body sensation in eyes | 77.39 | 13.91 | 23 | 10942 | 2134 | 79731289 |
| Astigmatism | 76.32 | 13.91 | 20 | 10945 | 1169 | 79732254 |
| Cystoid macular oedema | 74.92 | 13.91 | 22 | 10943 | 1958 | 79731465 |
| Corneal infiltrates | 73.00 | 13.91 | 15 | 10950 | 295 | 79733128 |
| Corneal deposits | 71.34 | 13.91 | 16 | 10949 | 482 | 79732941 |
| Keratitis | 69.10 | 13.91 | 25 | 10940 | 4297 | 79729126 |
| Choroiditis | 68.72 | 13.91 | 19 | 10946 | 1362 | 79732061 |
| Eye inflammation | 66.30 | 13.91 | 27 | 10938 | 6386 | 79727037 |
| Corneal transplant | 65.60 | 13.91 | 14 | 10951 | 333 | 79733090 |
| Keratitis bacterial | 63.21 | 13.91 | 12 | 10953 | 154 | 79733269 |
| Photophobia | 61.09 | 13.91 | 37 | 10928 | 20491 | 79712932 |
| Hypotony of eye | 57.93 | 13.91 | 12 | 10953 | 246 | 79733177 |
| Corneal perforation | 54.63 | 13.91 | 14 | 10951 | 749 | 79732674 |
| Conjunctival hyperaemia | 54.05 | 13.91 | 21 | 10944 | 4392 | 79729031 |
| Vitreous haemorrhage | 53.89 | 13.91 | 20 | 10945 | 3693 | 79729730 |
| Corneal graft rejection | 53.25 | 13.91 | 9 | 10956 | 56 | 79733367 |
| Iritis | 49.55 | 13.91 | 19 | 10946 | 3836 | 79729587 |
| Corneal thinning | 49.35 | 13.91 | 10 | 10955 | 183 | 79733240 |
| Iridocyclitis | 46.70 | 13.91 | 18 | 10947 | 3686 | 79729737 |
| NPM1 gene mutation | 46.35 | 13.91 | 9 | 10956 | 131 | 79733292 |
| Visual impairment | 44.54 | 13.91 | 59 | 10906 | 92072 | 79641351 |
| Keratitis fungal | 44.19 | 13.91 | 10 | 10955 | 314 | 79733109 |
| Blindness | 43.54 | 13.91 | 34 | 10931 | 28349 | 79705074 |
| Rhegmatogenous retinal detachment | 43.33 | 13.91 | 9 | 10956 | 187 | 79733236 |
| Cataract subcapsular | 42.24 | 13.91 | 12 | 10953 | 949 | 79732474 |
| Vitreous floaters | 40.98 | 13.91 | 20 | 10945 | 7236 | 79726187 |
| Persistent corneal epithelial defect | 39.99 | 13.91 | 7 | 10958 | 55 | 79733368 |
| Chimerism | 39.63 | 13.91 | 9 | 10956 | 287 | 79733136 |
| Retinal detachment | 39.18 | 13.91 | 21 | 10944 | 9226 | 79724197 |
| Hyphaema | 38.44 | 13.91 | 11 | 10954 | 893 | 79732530 |
| Bronchiolitis obliterans syndrome | 38.42 | 13.91 | 9 | 10956 | 330 | 79733093 |
| Ocular discomfort | 38.29 | 13.91 | 17 | 10948 | 4966 | 79728457 |
| Vitreous opacities | 36.90 | 13.91 | 10 | 10955 | 665 | 79732758 |
| Complications of transplant surgery | 35.76 | 13.91 | 10 | 10955 | 747 | 79732676 |
| Iris adhesions | 34.16 | 13.91 | 9 | 10956 | 537 | 79732886 |
| Macular oedema | 33.67 | 13.91 | 16 | 10949 | 5458 | 79727965 |
| Infective keratitis | 33.45 | 13.91 | 6 | 10959 | 55 | 79733368 |
| Iris atrophy | 33.28 | 13.91 | 7 | 10958 | 155 | 79733268 |
| Flat anterior chamber of eye | 33.28 | 13.91 | 7 | 10958 | 155 | 79733268 |
| Fibrous histiocytoma | 31.70 | 13.91 | 9 | 10956 | 710 | 79732713 |
| Eye infection | 31.69 | 13.91 | 20 | 10945 | 11900 | 79721523 |
| Corneal abrasion | 30.90 | 13.91 | 10 | 10955 | 1229 | 79732194 |
| Tractional retinal detachment | 30.73 | 13.91 | 6 | 10959 | 90 | 79733333 |
| Blindness unilateral | 30.37 | 13.91 | 17 | 10948 | 8129 | 79725294 |
| Necrotising scleritis | 30.36 | 13.91 | 7 | 10958 | 239 | 79733184 |
| Eye discharge | 29.26 | 13.91 | 15 | 10950 | 6019 | 79727404 |
| Scleral thinning | 28.16 | 13.91 | 5 | 10960 | 43 | 79733380 |
| Immobile | 27.22 | 13.91 | 15 | 10950 | 6958 | 79726465 |
| Lacrimation increased | 26.27 | 13.91 | 23 | 10942 | 22454 | 79710969 |
| Corynebacterium infection | 26.20 | 13.91 | 9 | 10956 | 1329 | 79732094 |
| Retinal vasculitis | 26.10 | 13.91 | 9 | 10956 | 1344 | 79732079 |
| Off label use | 26.07 | 13.91 | 213 | 10752 | 907002 | 78826421 |
| Scleral disorder | 25.97 | 13.91 | 6 | 10959 | 207 | 79733216 |
| Idiopathic intracranial hypertension | 24.78 | 13.91 | 11 | 10954 | 3211 | 79730212 |
| Cytomegalovirus chorioretinitis | 24.76 | 13.91 | 13 | 10952 | 5477 | 79727946 |
| Infectious crystalline keratopathy | 24.58 | 13.91 | 4 | 10961 | 19 | 79733404 |
| Pupillary disorder | 24.45 | 13.91 | 7 | 10958 | 569 | 79732854 |
| Keratoplasty | 23.68 | 13.91 | 3 | 10962 | 0 | 79733423 |
| Eye disorder | 23.52 | 13.91 | 22 | 10943 | 23390 | 79710033 |
| Transplant rejection | 22.94 | 13.91 | 20 | 10945 | 19417 | 79714006 |
| Instillation site pain | 22.88 | 13.91 | 7 | 10958 | 716 | 79732707 |
| Angle closure glaucoma | 22.38 | 13.91 | 10 | 10955 | 2966 | 79730457 |
| Blepharitis | 21.91 | 13.91 | 10 | 10955 | 3114 | 79730309 |
| Anterior chamber fibrin | 21.68 | 13.91 | 5 | 10960 | 171 | 79733252 |
| Open angle glaucoma | 21.55 | 13.91 | 6 | 10959 | 441 | 79732982 |
| Bipolar II disorder | 21.50 | 13.91 | 6 | 10959 | 445 | 79732978 |
| Ocular hypertension | 21.37 | 13.91 | 8 | 10957 | 1512 | 79731911 |
| Blood immunoglobulin G decreased | 21.08 | 13.91 | 10 | 10955 | 3399 | 79730024 |
| Osteoporosis | 20.70 | 13.91 | 31 | 10934 | 54081 | 79679342 |
| Optic nerve cupping | 20.55 | 13.91 | 4 | 10961 | 59 | 79733364 |
| Eye infection toxoplasmal | 20.30 | 13.91 | 6 | 10959 | 546 | 79732877 |
| Iris hypopigmentation | 20.19 | 13.91 | 4 | 10961 | 65 | 79733358 |
| Anterior chamber inflammation | 20.07 | 13.91 | 6 | 10959 | 568 | 79732855 |
| Conjunctivitis | 19.96 | 13.91 | 21 | 10944 | 25694 | 79707729 |
| CSF pressure increased | 19.76 | 13.91 | 5 | 10960 | 254 | 79733169 |
| Choroidal detachment | 19.46 | 13.91 | 6 | 10959 | 630 | 79732793 |
| Keratopathy | 19.44 | 13.91 | 7 | 10958 | 1187 | 79732236 |
| Foreign body in eye | 19.39 | 13.91 | 5 | 10960 | 274 | 79733149 |
| Tuberculosis of eye | 19.22 | 13.91 | 4 | 10961 | 84 | 79733339 |
| Necrotising retinitis | 19.15 | 13.91 | 7 | 10958 | 1238 | 79732185 |
| Immunosuppression | 18.91 | 13.91 | 15 | 10950 | 12788 | 79720635 |
| Metamorphopsia | 18.89 | 13.91 | 7 | 10958 | 1286 | 79732137 |
| Corneal endotheliitis | 18.87 | 13.91 | 4 | 10961 | 92 | 79733331 |
| Graft complication | 18.49 | 13.91 | 6 | 10959 | 743 | 79732680 |
| Vitreous haze | 18.36 | 13.91 | 4 | 10961 | 105 | 79733318 |
| Acute graft versus host disease in skin | 18.26 | 13.91 | 12 | 10953 | 7646 | 79725777 |
| Acute myeloid leukaemia recurrent | 18.13 | 13.91 | 9 | 10956 | 3374 | 79730049 |
| Glare | 18.01 | 13.91 | 4 | 10961 | 115 | 79733308 |
| Corneal erosion | 17.86 | 13.91 | 5 | 10960 | 375 | 79733048 |
| Articular disc disorder | 17.84 | 13.91 | 3 | 10962 | 18 | 79733405 |
| Steroid diabetes | 17.83 | 13.91 | 9 | 10956 | 3497 | 79729926 |
| Epstein-Barr virus associated lymphoproliferative disorder | 17.76 | 13.91 | 9 | 10956 | 3523 | 79729900 |
| Conjunctival retraction | 17.70 | 13.91 | 3 | 10962 | 19 | 79733404 |
| Corneal thickening | 17.44 | 13.91 | 3 | 10962 | 21 | 79733402 |
| Radiation pneumonitis | 16.85 | 13.91 | 9 | 10956 | 3924 | 79729499 |
| Corneal neovascularisation | 16.74 | 13.91 | 4 | 10961 | 160 | 79733263 |
| Anterior chamber flare | 16.71 | 13.91 | 4 | 10961 | 161 | 79733262 |
| Product delivery mechanism issue | 16.46 | 13.91 | 4 | 10961 | 172 | 79733251 |
| Lower limb fracture | 16.34 | 13.91 | 18 | 10947 | 23197 | 79710226 |
| Posterior capsule opacification | 16.03 | 13.91 | 4 | 10961 | 192 | 79733231 |
| Conjunctival haemorrhage | 15.99 | 13.91 | 10 | 10955 | 5855 | 79727568 |
| Mycotic endophthalmitis | 15.91 | 13.91 | 4 | 10961 | 198 | 79733225 |
| Ciliary body disorder | 15.77 | 13.91 | 3 | 10962 | 39 | 79733384 |
| Cytomegalovirus infection | 15.70 | 13.91 | 24 | 10941 | 42620 | 79690803 |
| Bedridden | 15.42 | 13.91 | 13 | 10952 | 12066 | 79721357 |
| Product container issue | 15.30 | 13.91 | 6 | 10959 | 1285 | 79732138 |
| Aortic aneurysm rupture | 15.28 | 13.91 | 6 | 10959 | 1289 | 79732134 |
| Vitreous disorder | 14.89 | 13.91 | 4 | 10961 | 257 | 79733166 |
| Toxicity to various agents | 14.71 | 13.91 | 22 | 10943 | 421518 | 79311905 |
| Macular fibrosis | 14.69 | 13.91 | 5 | 10960 | 718 | 79732705 |
| Diffuse large B-cell lymphoma refractory | 14.69 | 13.91 | 6 | 10959 | 1429 | 79731994 |
| Scleromalacia | 14.65 | 13.91 | 3 | 10962 | 58 | 79733365 |
| Ophthalmic herpes simplex | 14.64 | 13.91 | 5 | 10960 | 725 | 79732698 |
| Eye pruritus | 14.56 | 13.91 | 16 | 10949 | 20554 | 79712869 |
| Eye swelling | 14.42 | 13.91 | 18 | 10947 | 26450 | 79706973 |
| Intraocular pressure fluctuation | 14.19 | 13.91 | 3 | 10962 | 68 | 79733355 |
| Ciliary hyperaemia | 14.03 | 13.91 | 3 | 10962 | 72 | 79733351 |
| Overdose | 13.97 | 13.91 | 4 | 10961 | 184202 | 79549221 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D005938 | Glucocorticoids |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
| Iridocyclitis | indication | 77971008 | |
| Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
| Uveitis | indication | 128473001 | DOID:13141 |
| Infective blepharitis | indication | 312219000 | |
| Superficial Ocular Infection | indication | ||
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Herpes simplex keratitis | contraindication | 9389005 | |
| Herpes simplex dendritic keratitis | contraindication | 29943008 | |
| Fungal infection of eye | contraindication | 31194008 | |
| Severe myopia | contraindication | 34187009 | |
| Tuberculosis of eye | contraindication | 49107007 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Krukenberg spindle | contraindication | 85430004 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Eye infection | contraindication | 128351009 | |
| Bacterial infection of eye | contraindication | 128984004 | |
| Viral eye infection | contraindication | 312132001 | |
| Vaccinia keratitis | contraindication | 397552005 | |
| Porphyria | contraindication | 418470004 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Conjunctivitis | Indication |
| Dogs | Otitis externa | Indication |
| Cats | Inflammation | Indication |
| Cats | Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis | Indication |
| Cats | Supportive therapy in nonspecific dermatosis such as summer eczema and atopy | Indication |
| Cats | Supportive therapy pre- and post-operatively | Indication |
| Cats | Infectious allergic keratitis | Indication |
| Cats | Traumatic keratitis | Indication |
| Cats | Conjunctivitis | Indication |
| Cats | Otitis externa | Indication |
| Cats | Chronic otitis externa | Indication |
| Dogs | Inflammation | Indication |
| Dogs | Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis | Indication |
| Dogs | Supportive therapy in nonspecific dermatosis such as summer eczema and atopy | Indication |
| Dogs | Supportive therapy pre- and post-operatively | Indication |
| Dogs | Infectious allergic keratitis | Indication |
| Dogs | Traumatic keratitis | Indication |
| Dogs | Chronic otitis externa | Indication |
| Horses | Inflammation | Indication |
| Horses | Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis | Indication |
| Horses | Supportive therapy in nonspecific dermatosis such as summer eczema and atopy | Indication |
| Horses | Supportive therapy pre- and post-operatively | Indication |
| Horses | Infectious allergic keratitis | Indication |
| Horses | Traumatic keratitis | Indication |
| Horses | Conjunctivitis | Indication |
| Horses | Otitis externa | Indication |
| Horses | Chronic otitis externa | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Meticortelone Acetate | Intervet Inc. | 1 |
| Neo-Delta-Cortef with Tetracaine Ointment | Zoetis Inc. | 3 |
| Neo-Delta Cortef Sterile Solution | Zoetis Inc. | 2 |
| Surolan | Elanco US Inc. | 3 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.65 | acidic |
| pKa2 | 13.36 | acidic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| EQ 15MG BASE/5ML | FLO-PRED | TARO | N022067 | Jan. 17, 2008 | DISCN | SUSPENSION | ORAL | 7799331 | Oct. 11, 2028 | TREATMENT OF ALLERGIC REACTIONS |
| EQ 15MG BASE/5ML | FLO-PRED | TARO | N022067 | Jan. 17, 2008 | DISCN | SUSPENSION | ORAL | 7799331 | Oct. 11, 2028 | TREATMENT OF ASTHMA |
| EQ 5MG BASE/5ML | FLO-PRED | TARO | N022067 | Jan. 17, 2008 | DISCN | SUSPENSION | ORAL | 7799331 | Oct. 11, 2028 | TREATMENT OF ALLERGIC REACTIONS |
| EQ 5MG BASE/5ML | FLO-PRED | TARO | N022067 | Jan. 17, 2008 | DISCN | SUSPENSION | ORAL | 7799331 | Oct. 11, 2028 | TREATMENT OF ASTHMA |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017989 | VUID |
| N0000179219 | NUI |
| D00980 | KEGG_DRUG |
| 4017988 | VANDF |
| 4017989 | VANDF |
| C0071839 | UMLSCUI |
| CHEBI:8380 | CHEBI |
| CHEBI:8378 | CHEBI |
| TUA | PDB_CHEM_ID |
| CHEMBL1152 | ChEMBL_ID |
| DB15566 | DRUGBANK_ID |
| C009935 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5834 | PUBCHEM_CID |
| 8B2807733D | UNII |
| DB00860 | DRUGBANK_ID |
| 34372 | RXNORM |
| 25176 | MMSL |
| 4601 | MMSL |
| 5347 | MMSL |
| 5348 | MMSL |
| 59710 | MMSL |
| d00084 | MMSL |
| 002155 | NDDF |
| 002156 | NDDF |
| 116601002 | SNOMEDCT_US |
| 52388000 | SNOMEDCT_US |
| 96334000 | SNOMEDCT_US |
| C0032950 | UMLSCUI |
| 535 | INN_ID |
| 5755 | PUBCHEM_CID |
| D011239 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PRED-G | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-0066 | OINTMENT | 6 mg | OPHTHALMIC | NDA | 17 sections |
| PRED-G | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-0106 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA | 18 sections |
| BLEPHAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-0313 | OINTMENT | 2 mg | OPHTHALMIC | ANDA | 19 sections |
| BLEPHAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 11980-022 | SUSPENSION/ DROPS | 2 mg | OPHTHALMIC | NDA | 20 sections |
| PRED MILD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11980-174 | SUSPENSION/ DROPS | 1.20 mg | OPHTHALMIC | NDA | 18 sections |
| PRED MILD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11980-174 | SUSPENSION/ DROPS | 1.20 mg | OPHTHALMIC | NDA | 18 sections |
| PRED FORTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11980-180 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA | 18 sections |
| PRED FORTE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11980-180 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA | 18 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0559 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 18 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0559 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 18 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0561 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 17 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1912 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 18 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1912 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 18 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5275 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 18 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5275 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 18 sections |
| Flo-Pred | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1338 | SUSPENSION | 16.70 mg | ORAL | NDA | 25 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-265 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 18 sections |
| BLEPHAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-0634 | SUSPENSION/ DROPS | 2 mg | OPHTHALMIC | NDA | 21 sections |
| BLEPHAMIDE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-1157 | OINTMENT | 2 mg | OPHTHALMIC | ANDA | 19 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4293 | SUSPENSION | 10 mg | OPHTHALMIC | NDA authorized generic | 17 sections |
| PRED MILD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6355 | SUSPENSION/ DROPS | 1.20 mg | OPHTHALMIC | NDA | 18 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60758-119 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 19 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60758-119 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA AUTHORIZED GENERIC | 19 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-637 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 18 sections |
| Prednisolone Acetate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-637 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 18 sections |
| PREDNISOLONE ACETATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-2222 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | NDA authorized generic | 19 sections |
| Prednisolone Acetate PF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70261-501 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | unapproved drug other | 2 sections |
| Pred-Gati | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70261-502 | SUSPENSION | 10 mg | OPHTHALMIC | unapproved drug other | 2 sections |
| Pred-Gati-Brom | HUMAN PRESCRIPTION DRUG LABEL | 3 | 70261-504 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | unapproved drug other | 2 sections |
| Pred-Brom | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70261-505 | SUSPENSION/ DROPS | 10 mg | OPHTHALMIC | unapproved drug other | 2 sections |