pipenzolate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2185 13473-38-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pipenzolate
  • pipenzolate bromide
  • Molecular weight: 354.47
  • Formula: C22H28NO3
  • CLOGP: 0.69
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -6.02
  • ROTB: 6

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.481 Moderate 0.77
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.675 Moderate 0.77
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.617 10^-6 cm/s Moderate 0.77
dh-clint Dog hepatocyte intrinsic clearance 3.396 uL/min/10^6 cells Moderate 0.77
dppb Dog plasma protein binding (% unbound) 68.830 % Moderate 0.77
fcs-ppb Fetal calf serum protein binding (% unbound) 58.050 % Moderate 0.77
herg hERG pIC50 4.475 pIC50 Moderate 0.77
hh-clint Human hepatocyte intrinsic clearance 1.199 uL/min/10^6 cells Moderate 0.77
hlm-clint Human liver microsomal intrinsic clearance 3.673 uL/min/mg protein Moderate 0.77
hppb Human plasma protein binding (% unbound) 66.150 % Moderate 0.77
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 21
kinase-selectivity-class AXL,GRK2,PDK4 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.156 Moderate 0.77
mh-clint Mouse hepatocyte intrinsic clearance 58.884 Moderate 0.77
mppb Mouse plasma protein binding (% unbound) 68.880 Moderate 0.77
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.400 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 78.520 % Moderate 0.77
rh-clint Rat hepatocyte intrinsic clearance 62.087 uL/min/10^6 cells Moderate 0.77
rh-fuinc Rat hepatocyte fraction unbound in incubation 83.080 % Moderate 0.77
rppb Rat plasma protein binding (% unbound) 58.940 % Moderate 0.77
solubility-dd Solubility at pH 7.4 in DMSO 895.365 uM Moderate 0.77

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB14 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds
ATC A03CA09 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Synthetic anticholinergic agents in combination with psycholeptics

Related Drugs by ATC class:

A03AB Synthetic anticholinergics, quaternary ammonium compounds 19 drugs
(2-benzhydryloxyethyl)diethyl-methylammonium iodidebenziloniumbevoniumdiphemanilfenpiveriniumglycopyrronium bromidehexocycliumisopropamidemepenzolatemethantheliniumotilonium bromideoxyphenonium show all 19 →
A03CA Synthetic anticholinergic agents in combination with psycholeptics 10 drugs
ambutoniumbevoniumclidiniumdiphemanilemeproniumglycopyrronium bromideisopropamideotilonium bromideoxyphencycliminepropantheline

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07084 KEGG_DRUG
C0071103 UMLSCUI
CHEBI:749913 CHEBI
CHEMBL1619528 ChEMBL_ID
DB13844 DRUGBANK_ID
C004377 MESH_SUPPLEMENTAL_RECORD_UI
4832 PUBCHEM_CID
125-51-9 SECONDARY_CAS_RN
RS3K5YXV34 UNII
202840 RXNORM
001742 NDDF
004698 NDDF
387425004 SNOMEDCT_US
74798006 SNOMEDCT_US
CHEMBL1401367 ChEMBL_ID
652 INN_ID

Pharmaceutical products:

None